SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 FGF20 THEM4 ATP6V1H MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 MAPK3 PTPN1 INSR PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 KLB FLT3 IRS1 PDE3B IRS2 PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 PTPRF FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 TRIB3 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 ABCA3 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2C GRIN2B NRGN GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer MAPK1 PIK3CB PIK3R2 PIK3R1 PIK3CA MAPK3 CLIP1 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC25A15 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 DEFB4B S100A8 LTF TLR2 S100A7 DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation PLK1 TCF7L2 CCNB1 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B TBX2 HINT1 CCND1 SIN3A CDK2 CTNNB1 MET RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 ATF5 ATF3 ATF4 GRB10 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements YWHAB HSPB1 ELAVL1 PSMD8 PSMD6 ZFP36 PSMD7 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 CCNB2 NEK9 CCNB1 NEK6 NEK7 CDK1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle HNRNPC CCT7 RBMX DBN1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA UBC ZBP1 TREX1 RPS27A DDX41 DTX4 TBK1 IRF3 STING1 NLRP4 UBA52 TRIM32 TRIM21 TRIM56 UBB CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG4 GUSB ARSB IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 CDKN1A DEK FLI1 KLF5 H2AC20 LEF1 CDK2 CEBPB MYC E2F1 TFDP1 TFDP2 CDK4 H2AX CSF3R SPI1 GFI1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TAL1 H2BC11 RARA CEBPA KMT2A CBFB CEBPE GATA2 H3C15 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling RXRA SCD FASN CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 FABP6 EP300 APOC2 APOC1 AGO1 ANGPTL3 AGO2 PLIN1 TNRC6A ABCG1 TNRC6B BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SRD5A3 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage XIAP CYCS CASP9 CASP7 APAF1 CASP3 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 CCNE1 STAT3 HDAC3 GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 RAC1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 ACTB CLIP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS GLUD1 GLUD2 KYAT1 RIMKLA GLUL RIMKLB PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 PLCG1 FGF20 FGF16 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development DLL1 POU3F3 WNT4 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling NTRK3 NTF3 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 YWHAB RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB RAPGEF3 SIPA1 RAPGEF4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide CA4 CA7 CA6 CA9 CA14 CA13 CA12 CA1 CA3 CA5B CA2 CA5A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 DICER1 TARBP2 TSN AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HBEGF EGFR HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia ARG1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CCT6A HSP90AA1 CDC37 HSP90AB1 RNF20 TWF1 SPEN MSI2 CCT2 RHOBTB2 CPSF7 ROCK1 ACTN1 ROCK2 TMOD3 GPS1 DDX39B CUL3 PHIP TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 ACTG1 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS1 GINS2 CDC45 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA AKT2 STRADB TSC2 TSC1 PRKAB1 YWHAB RPS6 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 AKT1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle TIAM1 ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 PIK3R2 NOXA1 PIK3R1 ABI1 NOX3 ESYT1 FERMT2 NOX1 ABR MCF2 CDC42 LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SRGAP2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 DIAPH3 ITGB1 GIT2 VAV2 CAV1 MCAM LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR2 TGFB1 TGFBR1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 HMGA1 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 TP53 H1-5 H1-4 HIRA UBN1 EP400 ASF1A INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway IL36B IL36G IL36RN IL1F10 IL1RL2 IL36A DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions DSCAM DCC DSCAML1 NTN1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle ARHGAP26 BAIAP2 VANGL1 ARHGAP32 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 DAAM1 CDC42EP3 TRIO CDC42EP2 RASGRF2 WAS ITSN1 PARD6A PLEKHG4B CHN1 PAK6 PREX1 STOM MCF2L PAK3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 CDC42BPB SRGAP2 ARHGEF10 CDC42BPA ARHGEF12 DEF6 PLEKHG2 KTN1 ARHGEF15 SHKBP1 DLC1 ARHGEF16 ARHGEF19 DIAPH3 VAV2 TIAM1 ARHGEF9 ARHGEF4 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF ARHGEF6 ARHGEF26 FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 MCF2 CDC42 FMNL3 FMNL1 FMNL2 LAMTOR1 TFRC SNAP23 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 SYDE1 ARHGAP42 OPHN1 ARHGDIB LBR GIT1 TMPO ARAP2 ARAP3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A ARHGAP17 ARHGAP21 PAK1 RACGAP1 PAK2 YKT6 PAK4 GIT2 CAV1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 NCAM1 ITGA5 ITGA9 EGFR CSNK2A1 CSNK2A2 PAK1 MAPK1 RAC1 CSNK2B NRP1 MAP2K1 MAP2K2 MAPK3 ITGB3 ITGB1 ITGA2B L1CAM VAV2 ITGAV MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal MGMT MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBC RPS27A UBA52 UBB ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans NCAM1 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TGFB1 TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 TNXB LRP4 ACAN TGFB2 LUM TGFB3 DSPP COL9A1 COL9A3 COL9A2 AGRN FMOD NCAN BGN DCN BCAN VCAN LAMA5 LAMA2 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN DAG1 ITGB3 ITGB1 ITGA2B ITGAV SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins H4C9 HDAC1 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I HDAC4 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 NUP205 CBX5 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis GCKR GCK PPP2R5D PRKACG PRKACA PRKACB PPP2CA PPP2CB HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 NUP37 PGK2 PFKL GNPDA1 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1 SUMO3 SUMO2 UBE2I SUMO1 RWDD3 UBA2 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes CREBBP SP1 BCL2 PDGFA MAFK AREG EGF NFE2L2 BCL2L1 EP300 NOTCH1 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN6 TNFRSF14 PTPN11 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR3 TAC3 TACR1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K NTF4 NTRK2 BDNF GAB1 PIK3R1 PIK3CA ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism GPT ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 HBEGF AREG EGF EGFR AKT2 CDKN1B MAPK1 CCND1 TGFA XPO1 FOS FOXO3 ELK1 SRF PTK2 AKT1 EREG MAPK3 UHMK1 BTC EPGN AKT3 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway ADCY5 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis GNG13 GNB2 PPP2R5B GNB1 PPP2R5A PPP2R5D PPP2R5C GNB4 GNB3 GNB5 GNGT1 GUCY1B2 GNGT2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PDE5A PLA2G4A PTPN11 FGR STIM1 KCNMA1 PPP2CA ORAI2 PPP2CB PECAM1 ORAI1 PDE9A PDE1B GNG3 PDE1A ITPR1 ITPR2 GNG2 ITPR3 GNG5 SRI GNG4 LRP8 GNG7 PDE11A KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 APOB TRPC7 NOS2 NOS3 PDE2A TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 PDE10A P2RX3 P2RX2 P2RX1 GNAS PPP2R1B PPP2R1A PTPN6 MAPK14 GNG10 GNG12 PPP2R5E GNG11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TRMT5 TYW2 TYW1 LCMT2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization CIDEC HILPDA CIDEA FITM1 HSD17B13 FITM2 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation UBC RPS27A RAB7A KPNA1 UBA52 ATP6V1H NOS2 VPS33B CORO1A HGS RAB5A KPNB1 UBB VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity UBC MAFK SKP2 RPS27A SKP1 RBX1 UBA52 FBXL17 BACH1 UBB CUL1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis OMA1 OPA1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ARHGAP10 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPK1 MAPK3 PPP2R1B PPP2R1A MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB ST6GALNAC3 MAN2A1 MGAT5 ST6GALNAC4 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC ST3GAL4 MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 ST6GAL1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors PTGDR PTGER4 PTGFR PTGER1 PTGIR TBXA2R PTGDR2 PTGER2 PTGER3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination HGS MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 TRIM25 NFRKB PSMD1 USP17L30 HIF1A YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 BRCC3 PSMA1 SNX3 RHOT1 PSMA2 RCE1 ZRANB1 UBA52 SIAH2 INO80 STAM PSMD12 TADA2B PSMD11 CYLD H2AC25 PSMD14 H2AC21 BAP1 PSMD13 WDR48 OTUD7A PSMA7 OTUD7B BABAM1 PSMB6 IFIH1 BABAM2 PSMB7 UCHL1 TRIM4 PSMB4 UIMC1 UFD1 PSMB5 ACTB IKBKG TOMM70 UBB RIPK2 PSMB2 ACTL6A PSMB3 JOSD2 UCHL3 UBC JOSD1 PSMB1 UCHL5 DDB2 RPS27A KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 RNF135 PSMC6 STAMBPL1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 MBD5 PSMC2 USP17L18 MBD6 USP17L17 TP53 USP9X USP17L19 MCRS1 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 IL33 USP3 USP2 MUL1 TGFB1 H2AC1 TGFBR1 CDC25A TGFBR2 FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 ABRAXAS1 SKP2 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B CDC20 NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 EP300 ASXL1 TNIP1 TNIP2 TNIP3 H2AC8 ASXL2 H2AC6 OTUD3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RHOA KDM1B AXIN1 APC UBE2D1 CDK1 BRCA1 BARD1 SEM1 CCNA2 CCNA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations POMK DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism GAMT GATM SLC6A7 SLC6A8 CKM CKMT1B SLC6A11 CKB SLC6A12 CKMT2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B EIF4E NUP214 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 UBB UBC RPS27A HSPA8 XRN2 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35C1 PDZD11 SLC25A5 APOD SLC25A4 SLC25A6 SLC35B3 LCN9 SLC35B2 SLC27A1 SLC35B4 SLC35D1 SLC35D2 LCN15 LCN12 SLC35A2 SLC35A3 SLC33A1 SLC5A6 ARL2BP LCN1 SLC29A4 SLC27A6 SLC28A2 SLC35A1 SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC27A4 ARL2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D CHRM2 HTR1A CHRM3 TAAR5 CHRM1 HTR1B CHRM4 TAAR2 CHRM5 ADRA2C HTR5A ADRA2B TAAR1 ADRA2A ADRB2 GPR143 ADRB3 HTR2B HTR2C ADRB1 ADRA1D HTR2A ADRA1B HTR4 ADRA1A HRH1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 INS MAPK1 MAPK3 PTPN1 PTPN11 SNW1 CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51D RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A YBX1 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 FGF16 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases LCK FYN FLT3LG FLT3 HCK SYK GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 F9 PROC F10 GGCX PROS1 FURIN PROZ F2 BGLAP GAS6 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA BCKDHB DBT DLD LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG LDLRAP1 AP2M1 CUBN CETP AMN ZDHHC8 APOA2 APOA1 LSR APOA4 PRKACG APOA5 NPC1 PRKACA SOAT1 PRKACB SOAT2 NPC2 APOE ANGPTL8 ANGPTL4 LPA CES3 ABCA1 SAR1B MTTP MYLIP LPL LMF2 LMF1 NR1H2 APOF APOC4 AP2S1 NR1H3 A2M LDLR GPIHBP1 FGF21 MBTPS1 APOBR APOC3 APOC2 AP2B1 APOC1 ANGPTL3 NCEH1 ALB ABCG1 P4HB MBTPS2 APOB UBA52 UBB UBC RPS27A VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 FLAD1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP1 MIP AQP11 AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions VASP FBLIM1 PXN TESK1 ILK PARVA PARVB FLNA FLNC ARHGEF6 RSU1 FERMT2 LIMS2 LIMS1 ACTN1 ITGB1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 ITCH PSMD14 SUFU BTRC PSMD13 NUMB PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP ELAC2 TRNT1 HSD17B10 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB ADCY1 ADCY8 CALM1 PRKAR1B PRKAR2B DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a MGAT2 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway FZD2 GNG13 FZD5 WNT5A FZD4 GNB2 PDE6G FZD6 GNB1 NFATC1 GNAO1 MAP3K7 GNB4 TCF7L2 GNB3 TCF7L1 GNB5 LEF1 GNGT1 TCF7 GNGT2 CTNNB1 PRKG2 TNRC6C MOV10 GNG3 AGO3 ITPR1 AGO4 ITPR2 GNG2 ITPR3 GNG5 GNG4 AGO1 GNG7 AGO2 TNRC6A GNG8 TNRC6B CAMK2A CALM1 PRKCA PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 GNG10 NLK PPP3R1 WNT11 PDE6B PDE6A GNG12 FZD3 GNG11 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing CPSF4 CPSF1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TYW5 NUP43 TYW3 RAE1 TRMT5 TYW2 NDC1 TYW1 RANBP2 SEC13 LCMT2 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TRMT10C PRORP ELAC2 TRNT1 HSD17B10 TP53RK CLP1 POP5 POP7 OSGEPL1 POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 RPP38 PUS3 METTL1 CSTF2 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU QNG1 TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 TSEN34 URM1 LAGE3 RPP14 TRDMT1 RTRAF TRMT10A ADAT1 NUP214 TPRKB TRMT1 ADAT3 TRIT1 ADAT2 XPOT TRMT6 FAM98B TRMT61A TRMT61B RAN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS HRAS SOS1 NTRK3 NTF3 NRAS ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 ATP2A3 SLC9B2 RAF1 ATP2A2 SCNN1G ATP2A1 SCNN1D SCNN1B SCNN1A ATP7A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPM1 ATP4B SRI TRPM2 ATP4A TRPM7 FXYD4 TRPM8 FXYD3 TRPM5 WNK1 TRPM6 FXYD2 TRPM3 WNK2 TRPM4 FXYD1 WNK3 TRPC7 FXYD7 TRPC5 FXYD6 MCOLN3 CUTC TRPC6 ATP2B4 RYR1 TRPA1 ATP2B3 RYR2 TRPC3 ATP2B2 RYR3 TRPC4 ATP2B1 UNC80 TRPC1 TRPV2 ATP7B TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN PDZD11 ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 TCIRG1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 ATP6V1E1 STOM ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 NEDD4L ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 SGK1 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 CAMK2B CAMK2D CAMK2A CALM1 CAMK2G UBA52 WWP1 UBB UBC RPS27A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBC RPS27A SMURF1 PARD6A CGN UBA52 F11R PRKCZ TGFB1 RHOA PARD3 TGFBR1 TGFBR2 FKBP1A ARHGEF18 UBB CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division PLK1 KIF23 PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 KIF20A ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling NRG1 PTK6 HBEGF EGF ERBB2 EGFR NRG3 EREG NRG4 BTC NRG2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism MOGAT3 MOGAT2 GPAM MOGAT1 PPP1CA ABHD5 FABP12 PRKACG GK3 GK2 PRKACA LIPE PRKACB AGMO GPAT2 DGAT2 GK DGAT1 PPP1CB FABP9 PPP1CC FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 FABP6 LPIN2 MGLL LPIN3 PLIN1 CAV1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP CITED1 CITED2 YEATS4 CITED4 TFAP2A TFAP2B WWOX EP300 TFAP2C TFAP2D TFAP2E ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP GPAM ERCC6 ANGPTL4 LPL RBM7 DPY30 CHD4 TBP EED SAP18 MTA2 CIDEC MTA1 MTA3 MED1 MORC2 ACSL1 ELOVL5 MED4 MED6 MED7 SCD ZNF141 HDAC1 ZNF382 SETD1B SETD1A SIN3A ZNF136 EHMT2 EHMT1 PHF20 ASH2L UBE2I ZNF28 AJUBA ZNF273 HCFC1 CCNH PPARGC1A PPARGC1B POLR2E ZNF264 POLR2F POLR2H POLR2K POLR2L GTF2H1 ZNF30 GTF2H2 ZNF257 GTF2H3 EZH2 GTF2H4 ZNF33A GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB ZNF331 MED16 ACTL6A MED17 MED12 MED14 MED13 KAT2B KAT2A MED10 ZNF324 MEN1 ZNF320 MED27 SIRT1 ZNF317 MED23 MCRS1 MED24 MED20 ABL1 ZNF547 ZNF224 MBD3 GATAD2B GATAD2A SUDS3 CDK8 CDK5 ZNF778 TADA3 ZNF454 OGT SIN3B WDR5 PSIP1 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 RB1 RBBP4 RBBP5 RBBP7 SMARCE1 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 CEBPA KMT2A H3C15 TDG RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 DEK H2AC20 ZNF418 HDAC3 GPS2 LIPE TBL1X ZNF354A DGAT2 NCOA1 ZNF649 FABP4 NCOR2 NCOR1 CHD3 TBL1XR1 LPIN1 MGLL CBX3 SUMO2 RRP8 SAP130 PLIN1 DPF1 HDAC2 PDK4 DPF2 KAT8 DPF3 SAP30BP HCFC2 SUZ12 WDR82 PAXIP1 PEX11A BAZ2A CBX5 KAT14 SETDB1 SS18L1 SMARCA5 ZZZ3 ARID1A TADA2A GSK3B ARID1B ZNF816 EZH1 PHF1 SUV39H1 SGF29 CD36 JARID2 NCOA2 ZNF610 SS18 NCOA6 SMARCB1 NCOA3 CCNC TET2 TET1 SF3B1 PPHLN1 BAZ1B TRIM28 PHF20L1 NR5A2 AEBP2 MTF2 TET3 PLIN4 PLIN2 MBD2 SMARCC1 MYBBP1A SMARCC2 MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 MTREX TASOR MBIP ZNF708 TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C SMARCA2 BCL7B SMARCA4 DNMT3B UBTF ZNF765 KDM6A DNMT3A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes PPARGC1A GCK FBXO32 G6PC1 CAT INS ABCA6 HDAC1 RETN POMC NPY SIN3A SOD2 PLXNA4 PCK1 NR3C1 FOXO4 ATXN3 TRIM63 SMAD2 SMAD4 AGRP SMAD3 FOXO6 FOXO1 HDAC2 IGFBP1 SIRT3 FOXO3 SREBF1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB AKT2 TSC2 TSC1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 HEXB ARSG HEXA ARSD B3GALNT1 GLB1L3 B3GALT4 M6PR GLB1L2 GALC GLA GLB1L GLB1 ARSB ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein PARP10 PARP6 GSK3A UBE2I PARP4 PARP16 GSK3B SUMO1 PARP9 PARP14 PARP8 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation NTRK1 KIDINS220 RAP1A CRK NGF BRAF YWHAB DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU FMO3 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death ITCH YWHAE YWHAQ YWHAG YWHAH UBE2L3 TNFSF10 UNC5A DAPK1 UNC5B DAPK2 DAPK3 FADD ELANE CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 APPL1 DFFB DFFA DBNL RIPK3 IL18 ACIN1 IL1A IL1B KPNB1 GAS2 PELI1 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 TICAM1 CHMP4C PKP1 CHMP4B CHMP4A LY96 SDCBP BMF MLKL BMX STK24 STK26 CHMP2B CHMP2A AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 CASP5 CASP4 PPP3R1 FLOT1 FLOT2 DNM1L DSP PDCD6IP OMA1 IRF1 OPA1 IRF2 DSG1 CHMP3 DSG3 CHMP6 CHMP7 PLEC UACA ADD1 BAK1 GZMB CDKN2A MAGED1 CTNNB1 MAPK8 BCL2L11 BAD CDH1 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 BBC3 UBC PSMB1 DSG2 RPS27A PRKN ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 PAK2 CASP9 CASP7 APAF1 DIABLO CASP3 XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC OGT TRAF2 HSP90AA1 KPNA1 CDC37 BIRC2 BIRC3 E2F1 TFDP1 TFDP2 ARHGAP10 AKT2 TP53BP2 OCLN TNFRSF10B TNFRSF10A STAT3 DYNLL1 DYNLL2 MAPK1 PPP1R13B TJP1 FAS FASLG MAPK3 PMAIP1 SATB1 CASP6 CASP1 APC STUB1 BAX TP63 BCL2 BCL2L1 SEM1 TP73 PTK2 AKT3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IFNG NFATC2 RUNX1 TNFRSF18 CTLA4 CBFB IL2RA FOXP3 IL2 CR1 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SRD5A3 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ST6GAL1 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 MVD ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1 AKT1 AKT2 AKT3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN NCSTN YWHAZ APH1B PSEN2 ADAM10 PSEN1 JAG1 APH1A DLL4 NOTCH4 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 AURKA PSMD14 PSMD13 PSMA7 PSMB6 FBXL18 FBXL7 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism HSPG2 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 IDUA EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 CTSL HPSE IDS THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOX1 TPO IYD DUOXA1 CGA DUOXA2 DUOX2 TSHB DIO1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 YAP1 TCF7L2 CDKN1A TCF7L1 SPP1 CDKN2A LEF1 TCF7 TGFB1 CCND1 MAMLD1 CTNNB1 BCL2L11 ITGAL RBPJ ITGA4 SMAD4 SMAD3 SMURF2 ZFHX3 SNW1 MYC SMURF1 HDAC4 TEAD1 SRC MDM2 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 BRD2 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 CCN2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 KRAS PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A KAT2B KAT2A EP300 JAG1 ADRM1 WWTR1 PSMC5 PSMC6 SEM1 PSMC3 RUNX1 PSMC4 PSMC1 RUNX3 PSMC2 TP53 MAML3 FOXO3 CBFB NOTCH1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions LCK FYN PECAM1 LYN INPP5D PTPN6 PLCG1 ITGB3 YES1 PTPN11 ITGAV LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants FLT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 ARHGEF6 BTK GNGT1 RHOA GNGT2 CDC42 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PAK1 PDPK1 PLCB3 PLCB1 GNG10 PLCB2 AKT1 GNG12 AKT3 GNG11 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 JAK2 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 P4HB PPIA SNRPA1 PAK2 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling CBL UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling PRKCA ADCY9 ADCY4 ADCY3 ADCY2 PLCG1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA CALM1 CAMK2G PRKCD DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets RPS6KA1 PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MEF2C MAPK7 MAPK14 MAPK11 MAPK1 ELK1 MAPK3 MEF2A RPS6KA3 RPS6KA5 PPP2R1B PPP2R1A RPS6KA2 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy PRKAG3 PLIN2 PLIN3 HSPA8 PRKAB2 PRKAA2 PRKAG1 PRKAB1 PRKAG2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions COL18A1 ITGA3 ITGB4 LAMA5 ITGA1 LAMA2 NID1 LAMB3 NID2 LAMC3 ITGA6 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 ITGA2 HSPG2 ITGA7 ITGB1 ITGAV BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism PDZD11 MCCC2 BTD SLC5A6 PC ACACA PCCA HLCS MCCC1 PCCB ACACB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 SEC11A SEC11C GATA4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events FOXM1 WEE1 LIN52 PLK1 CCNB1 EP300 CDC25C CENPF CDC25A RBBP4 CCNB2 LIN54 LIN37 MYBL2 LIN9 PKMYT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes H2BC9 H2AZ2 H4C9 PLK1 H2BC8 H2BC5 H2BC3 H3-4 CCNB1 H2BC1 H2AC20 RB1 CDK1 SET H2AX H2AB1 NCAPG2 H2AC19 SMC4 H2BC26 SMC2 H2AC14 H2BC12L NCAPH2 H2BC21 NCAPD3 MCPH1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT5A H3C15 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT6A STAT3 FBXL3 FBXL5 WRAP53 HDAC3 CCT2 KIF13A CCT3 SPHK1 SKIC2 CCNE2 TCP1 GBA1 CCNE1 DCAF7 CCT6B USP11 CCT7 FBXO4 AP3M1 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CCT8 CCT5 CCT4 FBXW2 NOP56 ARFGEF2 XRN2 GAPDHS FKBP9 TP53 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity PML TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 SRC TNRC6A TNRC6B CCND3 RUNX1 CCND2 CCND1 CDK6 CBFB PTPN11 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 CFTR STAM ACTB USP9X CCT6A TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 WWP2 WDR11 LETM1 TMEM59 VMA22 GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 ARMCX3 PKP4 RASAL2 STIP1 ACTG1 DDRGK1 PLXNA1 ANKRD26 NSFL1C CPD PLXNB1 ARHGAP11A ZNF512B CAPZB EFHD2 NCK2 DAAM1 WDR6 NCK1 DST PLEKHG6 NIPSNAP2 BLTP3B PARD6B SH3BP1 WHAMM WASF3 NDUFA5 PCDH7 SEMA4F SRGAP2 PTPN13 VAPB ATP6AP1 GOLGA3 CKB BAIAP2L2 KCTD13 FRS2 TMEM87A DIAPH1 GRB7 PIK3CA PIK3R3 SCFD1 DIAPH3 ITGB1 SPTBN1 CCDC88A ANLN FAF2 SOS1 KIF14 SH3RF1 NUDC AKAP12 HINT2 RAC2 MUC13 RHOG PIK3R2 RHOH PIK3R1 RHOF RHOC RHOJ RHOD RHOU RHOV RHOQ RHOA SAMM50 RHOB EMC3 MTX1 CAVIN1 MYO9A TRIP10 RTKN PRAG1 SYDE2 BASP1 ALDH3A2 ELMO2 DDX4 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 CDC42 PLD2 RHPN1 RHPN2 FAM83B ACBD5 MACO1 ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 DLG5 PICALM FMNL3 SRC DOCK5 DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 SOWAHC MTR TNFAIP1 RND2 RND3 RND1 CKAP4 SENP1 ZAP70 GFOD1 ALS2 PEAK1 NDUFS3 DOCK2 DOCK1 CCDC187 MOSPD2 FAM169A ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CSK FRS3 JAG1 LCK DBT CLTC HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 ARHGAP21 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 WAS PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 ARL13B RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 PRKCB CREBBP RUNX1 LGALS3 CBFB REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism WDR26 PDHB RMND5B LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GID4 GID8 UBC RPS27A PDK4 DLD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 CYP11B1 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC E2F1 RBBP4 E2F3 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PRKCB PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 PRKCA CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 PRKCG FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death JUN PRDX2 H2BC9 PRDX1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 CDC25B CDC25A LMNB1 BCL2L11 FASLG CDK5R1 RIPK1 CDK5 SUZ12 YWHAE TRAF2 EED CDC25C FADD GSDME C1QBP RBBP4 EZH2 GOLGA2 SOD2 CAPNS1 RIPK3 CAPNS2 CAPN2 RBBP7 CAPN1 CAST PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MLKL H2AC6 H2AC7 H2BC17 APP DNMT3B H2BC12 H2BC13 TRADD H2BC14 H2AJ DNMT3A H2BC15 TP53 CASP8 H2BC11 FOXO3 H3C15 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU PHB1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGF ERBB2 EGFR PLCG1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation FBLN5 LOXL1 ITGA5 LOXL2 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 FURIN MFAP5 BMP4 MFAP4 LOX MFAP3 MFAP2 FBN1 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization SGTA PEX10 PEX12 TOMM20 GFER GDAP1 PEX13 PEX14 OTC DHRS4 NUDT7 VAPA TOMM7 CRAT TOMM5 TOMM6 NOS2 STX5 CAT SLC25A4 SLC25A6 IDE PMPCB PMPCA SLC27A2 PECR SAMM50 ZFAND6 TOMM22 MTX1 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 SCP2 CHCHD7 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 CMC4 CMC2 PAM16 ECH1 PIPOX BCS1L GNPAT ACBD5 ACOT2 STX1A ACOT4 COX19 COX17 PEX11B ATP5MC1 TIMM50 BAG6 PITRM1 GRPEL1 ABCD3 GRPEL2 UBE2D2 LDHD UBE2D3 OTOF HMOX1 HACL1 HAO1 CYC1 DECR2 HAO2 DNAJC19 COA4 PRNP FIS1 EPHX2 IDH1 TYSND1 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 UBE2D1 AMACR DAO HSPD1 PXMP2 PXMP4 ACO2 ABCD2 UBA52 CROT HSCB SERP1 SEC61G TIMM17A TIMM17B GET1 SEC61B GET3 EMD ABCD1 COA6 GET4 CAMLG TIMM23 PEX2 TIMM22 HSPA9 PEX1 TIMM21 BAAT UBB TOMM70 PEX7 SLC25A17 ACOX2 ACOX1 UBC PEX3 EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PAOX NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 APP HSD17B4 TIMM10 DDO HMGCL ATP5F1A ATP5F1B USP9X UBL4A TIMM8B ATAD1 PEX16 TIMM8A PEX19 MTX2 IDH3G DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors F7 F9 PROC F10 GGCX PROS1 PROZ F2 BGLAP GAS6 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L PRKACA KIF7 PRKACB WDR35 IFT88 SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 GLI3 GLI2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 GNAS PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 BTRC NUMB PSMD13 OFD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PRKAR1B PSMC5 PRKAR2B PSMC6 PRKAR1A SEM1 PSMC3 PRKAR2A PSMC4 PSMC1 PSMC2 SKP1 CUL1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis AP2A1 AP2A2 AP2M1 ARF1 ATP6V1H CD4 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B HCK PACS1 ELMO1 RAC1 LCK CD28 FYN PAK2 DOCK2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction LCK RAC1 FYN PAK2 HCK DOCK2 ELMO1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 JUN PCNA COX5B COX5A PERP NPM1 COX6C TTC5 CCNG1 PRDM1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 NDRG1 HIGD1C CNOT10 CNOT11 TAF4B YWHAE PRR5 DYRK2 CHD4 TRIAP1 PIDD1 YWHAQ YWHAG ZNF385A YWHAH TBP TMEM219 TAF9 TAF1L AURKA MTA2 TAF15 TAF12 TAF13 TAF11 CARM1 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 PRDX2 PRDX1 PLK3 PRELID1 CDKN1A HDAC1 CDKN2A PLK2 CDK2 CDK12 CDK13 PRKAA1 PRKAA2 MDC1 ATF2 BTG2 MT-CO1 PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 RPTOR NOC2L CHM STK11 TNRC6C MOV10 MLST8 TAF7L SLC38A9 AGO3 ING5 AGO4 ING2 PRKAB2 PIP4P1 AIFM2 AGO1 TNKS1BP1 AGO2 TSC2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC MT-CO2 BRD1 MT-CO3 ELOB RHEB RRAGB ELOC RRAGD LAMTOR2 AKT1 MEAF6 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SFN BRD7 YWHAZ CCNH POLR2A POLR2B PRELID3A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K TIGAR POLR2L GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 POU4F2 SUPT5H HIPK2 GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB BBC3 UBC DDB2 RPS27A CASP10 CSNK2A1 MAPK14 MAPK11 CSNK2A2 CNOT6L TAF9B CSNK2B IGFBP3 KAT6A TP53 APAF1 CYCS USP7 PLAGL1 PMS2 USP2 RICTOR BID MBD3 MAP2K6 FANCI GATAD2B GATAD2A FANCC CNOT4 CNOT6 CNOT7 BCL6 CDK5 CNOT1 STEAP3 CNOT2 CNOT3 MDM2 MDM4 CNOT8 CNOT9 CCNT2 SESN3 PTEN SESN2 KMT5A GPX2 BNIP3L CDC25C RNF34 CDKN1B NLRC4 MSH2 E2F1 RBBP4 MAPKAPK5 DAXX TFDP1 RBBP7 CCNE2 TFDP2 RFFL CCNE1 PPP2R1B TXNRD1 PPP2R1A CPAP PML TAF10 TP53RK EP300 AKT2 TP53AIP1 CHEK2 SMYD2 COX7A2L PDPK1 TXN NUAK1 TP53BP2 BANP GADD45A BCL2L14 TPX2 ZNF420 BRPF1 BRPF3 TNFRSF10C TNFRSF10B PRMT5 TNFRSF10A PPP2R5C PRMT1 TNFRSF10D RGCC SGK1 PIN1 BIRC5 MLH1 PPP1R13B COX4I1 FAS COX4I2 PPP1R13L CDK5R1 AURKB PPP2CA PPP2CB FANCD2 COXFA4 RABGGTB COX7A2 RABGGTA COX7A1 CHD3 RRM2B PMAIP1 TP53INP1 HDAC2 TP53I3 E2F4 JMY E2F7 E2F8 CASP6 CASP1 CASP2 RBL2 RBL1 GPI CCNK CCNB1 GLS2 GLS CDK1 ARID3A BAX BLM TP63 MRE11 BRCA1 CTDP1 ELL WRN BRIP1 CCNT1 KAT5 SUPT4H1 ELOA EXO1 CHEK1 NELFB NELFCD RBBP8 NELFA NBN NELFE TOPBP1 L3MBTL1 ATRIP SUPT16H BARD1 CREBBP RFC5 RMI2 ELOA2 RFC3 SSRP1 CDK9 RFC4 RMI1 TCEA1 PCBP4 RFC2 TOP3A RPA1 HUS1 RPA2 CRADD RAD50 RAD51D TP73 COX7B RPA3 RAD17 FOS RAD1 CCNA2 ATM CCNA1 DNA2 COX7C RAD9B RHNO1 ATR COX8A RAD9A COX8C AKT3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D KIF17 GRIN1 RPS6KA6 DLG1 CASK GRIN2A LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIA3 CALM1 CAMK2G GRIA4 GRIN3B GRIN3A APBA1 CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 NBEA RPS6KA3 RPS6KA2 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity USP7 USP2 RICTOR TTC5 CCNG1 MBD3 PRDM1 MAP2K6 GATAD2B GATAD2A CDK5 MDM2 MDM4 TAF4B PRR5 DYRK2 CHD4 KMT5A ZNF385A TBP TAF9 TAF1L RNF34 AURKA MTA2 TAF15 TAF12 RBBP4 TAF13 MAPKAPK5 TAF11 DAXX RBBP7 TAF8 TAF7 RFFL TAF6 TAF5 PPP2R1B TAF4 PPP2R1A TAF3 TAF2 PML TAF1 PIP4K2A TAF10 TP53RK PIP4K2B EP300 PIP4K2C AKT2 CHEK2 SMYD2 PDPK1 NUAK1 TP53BP2 BANP MAPKAP1 TPX2 BRPF1 BRPF3 PRMT5 PLK3 PPP2R5C HDAC1 CDKN2A SGK1 PIN1 CDK2 PPP1R13B PPP1R13L PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 PPP2CA NOC2L STK11 PPP2CB MLST8 CHD3 TAF7L ING5 ING2 PRKAB2 PIP4P1 TP53INP1 HDAC2 PRKAB1 MTOR JMY BRD1 AKT1 MEAF6 BRD7 UBA52 CDK1 HIPK1 POU4F1 BLM POU4F2 MRE11 TP63 HIPK2 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 SUPT16H L3MBTL1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CSNK2A2 TAF9B RAD50 CSNK2B TP73 KAT6A RPA3 RAD17 TP53 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A AKT3 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation LTF REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity XIAP RNF146 TNKS PREX2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 STUB1 PSMA6 PSMA3 TRIM27 PSMA4 WWP2 PSMA1 NEDD4 MKRN1 PSMA2 FRK UBA52 PSMD12 USP13 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A AKT2 ADRM1 CSNK2A1 PSMC5 OTUD3 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 AKT3 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 CYP17A1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants FLT3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 GIT1 CALM1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMA1 KCNMB1 CHRNA9 CHRNA10 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MLH1 RPA3 EXO1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) STPG4 METTL23 YAP1 UHRF1 H2BC9 DPPA4 H2AZ2 DPPA3 H4C9 DPPA2 H2BC8 ZFP36L2 H2BC5 LEUTX H2BC3 PAIP1 NPM2 H2BC1 KDM4E TPRX1 AICDA SRPK1 H2AC20 H1-8 TPRX2 ZSCAN4 HIRA CNOT4 CNOT6 CNOT7 EIF4E DICER1 EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 CNOT11 KDM5B TEAD4 PABPN1 PABPC1 TET3 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 BTG4 CNOT6L EIF4A2 H2BC12 KDM5A H2BC13 EIF4A1 H2BC14 TUT7 KDM6A H2AJ TUT4 H2BC15 EIF4G1 DUX4 TP53 PABPN1L H2BC11 TPRXL EIF4A3 DUXA DUXB DIS3L2 KDM6B PRM2 PRM1 H3C15 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA1 GNG13 GNB2 GNB1 AP2A1 ADCY9 GNB4 GNAL GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 CHRNA9 RASGRF2 PRKAR1B PRKAR2B PRKCB PRKAR1A RAC1 HRAS PRKAR2A PRKX PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF9 NRAS GRIP1 MAPK1 GNAT3 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 CHRNA1 CHRNA3 PRKAA1 CHRNA2 PRKAA2 MAPK3 CHRNA5 CHRNA4 CHRNA7 PRKAG1 CHRNA6 PRKAG2 EPB41L1 PRKAG3 TSPAN7 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK4 GRIK1 PRKAB2 GRIA1 GRIK2 GABRR3 CAMK2B GRIA2 GABRR2 GABRR1 CAMK2D NPTN SRC ACTN2 PRKAB1 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B NRGN PICK1 GRIN2D GNAI3 AKAP5 GRIN1 DLG1 GNAI1 GRIN2A NCALD DLG2 GNAI2 DLG3 CHRND LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE PRKCA CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 GIT1 KCNJ16 GLRB CAMK4 CAMKK1 CAMKK2 KPNA2 PRKCG GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade RHO PDE6G CNGA1 GNB1 GNAT1 SLC24A1 SAG PDE6B CNGB1 GNGT1 PDE6A DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 EED H2BC3 H2BC1 H2AC20 GSDME RBBP4 EZH2 RBBP7 PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock FBXL3 CDK5 RORC RORA RORB SMARCD3 BTRC CARM1 PPP1CC NAMPT EP300 MED1 KMT2A RXRA SERPINE1 HDAC3 NR1D1 NRIP1 TBL1X BMAL1 NCOA1 ATF2 NCOR1 MEF2C TBL1XR1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PPARGC1A PSMA6 PSMA3 UBE2D1 NCOA2 PSMA4 PSMA1 NCOA6 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PPP1CA PSMD13 PSMA7 PSMB6 CRTC2 PSMB7 CRTC3 CRTC1 CSNK1D PSMB4 CPT1A PPP1CB SIK1 PSMB5 CSNK1E CLOCK NPAS2 UBB HELZ2 PSMB2 RAI1 PSMB3 CREBBP BHLHE40 UBC CHD9 BHLHE41 PSMB1 RBM4 DBP RPS27A TFEB KLF15 FBXW11 CRY2 CRY1 AVP CIPC ADRM1 CSNK2A1 FBXL21P NOCT TGS1 PSMC5 CSNK2A2 MEF2D PSMC6 SEM1 PER2 PSMC3 PER1 PSMC4 F7 PER3 PSMC1 CSNK2B PSMC2 BMAL2 SIRT1 SKP1 SREBF1 CUL1 PPARA REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity GJA1 TJP1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 PIK3R1 PIK3CA SRC IRS1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L KCNJ11 SLC5A1 ABCC8 SLC5A2 ABCC9 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 SLC67A1 RNF185 SLC26A3 APOA1 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 VCP SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC6A19 SLC27A4 SLC36A2 SLC6A14 SLC7A7 SLC7A9 GCKR GCK ABCA1 ABCG8 ABCG5 ABCA3 PSMD8 PSMD6 HK1 PSMD7 PSMD2 PSMD3 PSMD1 NUP214 SLC5A5 PSMA5 SLC35C1 PSMA6 CFTR PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 SLC24A1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SLC17A5 RPS27A SLC9A6 AVP ADRM1 SLC9A9 PSMC5 PSMC6 SEM1 SLC35A1 PSMC3 PSMC4 PSMC1 PSMC2 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes CREBBP ATF4 MAFK NFE2L2 EP300 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARL13B INPP5E PDE6D CCT2 CCT3 SMO TCP1 ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP HDAC6 BBIP1 RHO RAB11A ATAT1 TTC8 CNGB1 RAB8A SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CCND1 MAMLD1 RBPJ TNRC6C MOV10 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B ELANE E2F1 E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation BRD7 BRPF1 BRPF3 HDAC1 MTA2 PIN1 RBBP4 MBD3 MAP2K6 RBBP7 GATAD2B GATAD2A PML CHD3 ING5 PIP4K2A ING2 PIP4K2B PIP4P1 EP300 PIP4K2C AKT2 HDAC2 BRD1 KAT6A TP53 CHD4 MEAF6 AKT1 AKT3 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM NCBP1 NCBP2 FGF1 POLR2A FGF2 POLR2B FGFR2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB ZFP36 DCP1A EXOSC7 EXOSC6 EXOSC5 TNPO1 EXOSC4 DIS3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) PCNA YY1 RUVBL1 PARP1 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 RBX1 NFRKB CCNH ACTR5 RAD23A ACTR8 RAD23B CETN2 UBA52 INO80 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB UBB TFPT ACTL6A LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 DDB2 POLD1 RPS27A POLE POLD2 PIAS3 RFC2 RFC1 PARP2 USP45 LIG3 RPA1 RNF111 CHD1L DDB1 RPA2 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 COPS6 COPS5 MCRS1 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD NCAN CSPG4 CHST3 BGN DCN BCAN VCAN CSPG5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID BBC3 BCL2 BCL2L11 STAT3 PMAIP1 BCL2L1 BAD BMF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism ACSS3 BDH2 BDH1 HMGCL OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development YAP1 RBM14 HES1 BGLAP ABL1 RB1 MAF HDAC3 COL1A1 MAPK1 HDAC6 SP7 IHH UCMA MAPK3 GLI3 SMAD1 GLI2 SMAD4 HEY1 HEY2 SMAD6 HDAC4 SRC WWTR1 YES1 SATB2 CBFB ZNF521 AR OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency OTC HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs FKBP5 HSP90AA1 DYNLL1 DCTN6 DCTN5 ACTR1A HSP90AB1 DCTN1 DYNLL2 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 CAPZA3 DNAJA4 DNAJA2 CAPZA2 DYNC1I2 FKBP4 NR3C1 ACTR10 STIP1 HSPA1B CAPZB DYNC1LI1 DYNC1I1 DYNC1LI2 DCTN2 HSPA8 DYNC1H1 CAPZA1 DCTN3 HSPA1A PGR AR REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling IFNG JAK2 JAK1 SOCS3 PTPN6 PIAS1 PTPN1 SOCS1 SUMO1 IFNGR1 IFNGR2 PTPN11 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD CSPG4 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 B3GAT3 CSPG5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 YAP1 BGLAP ABL1 IHH NR3C1 ESRRA STAT1 MSX2 SMAD1 SMAD4 ESR1 BMP2 ZNF521 RBM14 RB1 MAF HDAC6 SKP2 CDK4 DLX5 DLX6 AKT2 SOX9 RUNX1 TWIST2 TWIST1 CBFB ITGA5 CDKN1A HDAC3 MAPK1 CCND1 SP7 MAPK3 NKX3-2 GLI3 GLI2 HAND2 PPM1D SMURF1 SMAD6 HDAC4 SRC SATB2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B AR PSMA5 STUB1 PPARGC1A PSMA6 PSMA3 PSMA4 PPARGC1B PSMA1 CCNB1 PSMA2 HES1 LGALS3 UBA52 PSMD12 PSMD11 CDK1 COL1A1 PSMD14 WWP1 BAX PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UCMA PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 HEY2 HIVEP3 ADRM1 WWTR1 YES1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 ITGBL1 PSMC2 SKP1 MMP13 CUL1 AKT3 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB IKBKB SQSTM1 UBC MYD88 RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR PRKCI UBB RIPK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 SKP2 CCNE2 KPNB1 PRIM2 CCNE1 PRIM1 POLA1 H2AX POLA2 LIG1 H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 KPNA6 POLRMT POLG2 RNASEH1 FEN1 MCM10 POLG TWNK DBF4 MGME1 EXOG RPA4 SSBP1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 TOP3A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation PCNA GINS1 GINS2 CDC45 GINS3 GINS4 PRIM2 PRIM1 POLA1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 MCM7 MCM8 RPA3 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RRAS FES PLXNA2 TLN1 PIP5K1C FARP2 PLXNA3 RAC1 FYN RND1 PLXNA4 NRP1 PLXNA1 SEMA3A ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization PERP PI3 CAPNS1 CAPN1 PKP1 DSP DSG1 DSG3 LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G DSG2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 FURIN PCSK6 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KRT12 KLK14 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 JUP KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PKP4 LELP1 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 CELA2A KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate DCXR AKR1A1 SORD CRYL1 XYLB IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AZ2 H4C9 PRMT6 PRMT5 SMARCB1 SMARCD1 PRMT1 SMARCD2 SMARCD3 H2AC20 H2AC1 H2AC25 H2AC21 CCND1 JAK2 SMARCC1 SMARCC2 PRMT7 PRMT3 CARM1 RBBP7 WDR77 COPRS CDK4 ARID2 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2AC14 RPS2 H3C8 H2AC8 H2AC6 H2AC7 SMARCA2 ACTL6B SMARCA4 H2AC17 H2AC12 H2AJ DNMT3A WDR5 ARID1A ARID1B H3C15 PBRM1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IPPK IPMK IP6K1 IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR10 MTMR2 MTMR12 PIK3C2A MTMR4 MTM1 PIK3R4 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3C3 VAC14 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation PTK6 PTPN1 SRMS EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis RASGRP2 RASGRP1 ITPR1 ITPR2 MGLL ITPR3 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 TRPC7 ABHD12 PRKCH TRPC6 DGKZ DGKQ PRKCQ TRPC3 PRKCE DAGLB DGKK DGKI DGKH PRKCD RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle RXRA MID1IP1 SLC22A5 SLC25A20 CPT1B PPARD PRKAB2 CPT1A PRKAA2 CPT2 PRKAG2 THRSP G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events TIAM1 GNG13 ARHGEF9 SOS1 OBSCN GNB2 ARHGEF3 ARHGEF4 GNB1 ARHGEF1 ARHGEF2 ARHGEF7 GNB4 SOS2 GNB3 RHOC ARHGEF5 NGEF GNB5 ARHGEF6 ARHGEF26 GNGT1 RHOA KALRN RHOB FGD1 FGD2 GNGT2 ROCK1 GNA13 ROCK2 FGD3 ABR FGD4 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 GNG3 GNG2 GNG5 GNG4 TBXA2R GNG7 GNG8 BTK GNA12 PLXNB1 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 GNG10 ADRA1D ARHGEF16 ARHGEF19 ADRA1B ARHGEF18 VAV1 ADRA1A VAV2 GNG12 TIAM2 GNG11 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID IKBKB NFKB2 RELA CHUK NFKB1 NFKBIA IKBKG SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 EHHADH ABCD1 DECR2 SLC27A2 ACOT4 ACAA1 ACOT8 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling DNMT1 SIN3A STAT3 PRDM1 EP300 CD274 HDAC1 IL2RG HIF1A HDAC2 HDAC3 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PIK3CB STRN SOS1 KDR FIP1L1 STAT3 PIK3R2 PIK3R1 NRAS PDGFRA HRAS WDR48 STAT1 PIK3CA KANK1 ETV6 GOLGA4 BIN2 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 MAP2K5 MAPK7 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid RXRA PPARD DHRS4 PDHB RXRG PDK3 DLAT RXRB PDK2 PDK1 PDHX PDHA2 PDHA1 RARG FABP5 CYP26A1 CYP26B1 CYP26C1 ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 PDK4 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 RARB ALDH8A1 RARA DLD ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) RXRA GGPS1 SCD CYP51A1 FASN LSS SREBF2 SQLE NCOA2 MTF1 DHCR7 NCOA6 SMARCD3 ACACB GPAM NFYA MVD NFYB NFYC TBL1X CARM1 NCOA1 HELZ2 CREBBP CHD9 SP1 TBL1XR1 ACACA MED1 TGS1 IDI1 MVK ELOVL6 TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling NEDD4L STUB1 PMEPA1 BAMBI STRAP UBA52 TGFB1 TGFBR1 TGFBR2 PPP1CA USP15 PPP1R15A PPP1CB PPP1CC UBB UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD3 SMURF2 SMAD7 SMURF1 XPO1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism ARSB GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 GBA1 NEU2 ENPP7 NEU3 ARSA SUMF2 SUMF1 NEU1 ASAH1 ASAH2 ARSL ARSJ ARSK PSAP ARSH ARSI CTSA ARSF HEXB ARSG HEXA ARSD GLB1L3 M6PR GLB1L2 GALC GLA GLB1L GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 EGF HES1 EGFR WWC1 NEURL1B UBA52 DLGAP5 HES5 PLXND1 APH1A PTCRA DLL4 MIB2 PSENEN PBX1 NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 TACC3 MAMLD1 PSEN1 STAT1 UBB RBPJ CREBBP UBC MAML2 FABP7 MAML1 RPS27A YBX1 HEY1 KAT2B KAT2A EP300 JAG2 SNW1 HEY2 JAG1 DLL1 MAML3 NOTCH3 NOTCH1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS AP2A1 AP2A2 FURIN SAP30L AP2M1 ATP1B3 ATP1B2 ROCK1 ATP1B1 ROCK2 CUL3 IGHV3-23 ARID4A IGLV MBD3 COMT IGLV2-8 NR3C1 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 GATAD2B IGHV3-30 RIPK1 GATAD2A IL1R1 SUDS3 IGHV3-33 AP2S1 IGKV1D-39 ZBP1 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 FXYD4 PHF21A FXYD3 CD79B IGLV2-11 FXYD2 CD79A IGLV1-40 FXYD1 IGLV1-47 IGLV6-57 FXYD7 IGLV2-14 FXYD6 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CHD4 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV SAP18 IGKV2-29 IGKV2-28 IGLC3 ATP1A4 BLNK ATP1A3 HMG20B MTA2 IGLC1 ATP1A2 FNTB IGLC2 S1PR1 JAK3 ATP1A1 SIGMAR1 RBBP4 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 REST IGLV3-19 MTA3 IGHV2-70 RBBP7 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FNTA BRD4 CRBN IGLC7 IGHV3-53 IGKV5-2 NCK1 STAT2 IGLC6 IL6R IGKV1-5 IMPDH1 IMPDH2 PDCD1 ITGB1 VAV1 TLR9 SOS1 HDAC1 HSP90AB1 KDM1A PTGES3 FKBP4 IFNGR1 IFNGR2 ITGA4 CHD3 HDAC2 FKBP1A KEAP1 RBX1 BTK JAK2 TUBB ARID4B JAK1 SAP30 TYK2 NFE2L2 SYK SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling RRAS PLXNB1 ERBB2 RHOC ARHGAP35 SEMA4D RHOA LIMK2 RHOB LIMK1 RAC1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MET MYH10 MYL9 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 FKBP5 HTT HDAC1 GAD1 SGK1 GAD2 HDAC3 GPS2 SIN3A PRKACA MET TBL1X DGCR8 PTPN1 AURKB NCOR2 TNRC6C GPRIN1 MOV10 NCOR1 MEF2C TBL1XR1 AGO3 IRAK1 AGO4 RBFOX1 CAMK2B GRIA2 AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A GRIN2B PTEN SLC2A3 GRIN2A TRPC3 OPRM1 SST CALM1 CAMK2G PTPN4 CRH OPRK1 LBR HIPK2 PVALB FOXG1 SOX2 MOBP GAMT DLL1 CAMK4 BDNF PPARG CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation MIB2 ITCH HSPA5 SAR1B TLR1 S100A9 S100A8 TLR2 STX4 UBE2L3 CD14 BTRC TLR4 LY96 RNF111 UBE2V2 LRR1 HMGB1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SEC31A SOCS1 HACE1 SIAH1 LNPEP MEX3C IKBKB UBAC1 FBXL8 MYD88 CD207 CALR CANX FBXL4 DZIP3 RNF220 DET1 LRSAM1 CTSS MRC2 TRIM9 MRC1 ARIH2 LRRC41 VAMP8 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 TLR6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 PSMB8 PSMB9 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 NCF1 KLHL5 PSMA5 RLIM NCF2 PSMA6 TRIP12 NCF4 PSMA3 KBTBD7 SNAP23 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 BTK RNF19B UBE3A PSMD12 SEC61G UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 SEC61B NPEPPS PSMD13 RNF19A PSMA7 PDIA3 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 S100A1 UBE2E3 CYBB TRIM4 PSMB4 FBXO17 TAP2 CYBA PSMB5 FBXO15 IKBKG UBE2E2 TAP1 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 VAMP3 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 PSME2 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 CUL3 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 RBBP6 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 SMURF2 ASB13 B2M ASB14 ASB11 RNF6 ASB12 HLA-A RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 SEC13 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 BECN1 SEC24D ASB2 ASB3 SEC24C SKP2 ASB1 CDC20 SOCS3 PIK3C3 ITGAV SH3RF1 ITGB5 PIK3R4 FBXO32 CHUK MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 CD36 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FGB FGA FGG FBXW11 FBXL21P SEM1 SKP1 CTSV CTSL CUL1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis ENO1 TRIM27 KPNA1 UBA52 ATP6V1H MAPK1 CTSG DUSP16 VPS33B CORO1A PGK1 HGS RNF213 RAB5A KPNB1 MAPK3 UBB UBC RPS27A RAB7A B2M SFPQ MRC1 NOS2 LTF TLR2 GSK3A INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA AREG EGF EGFR EREG BTC EPGN SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF23 FGF4 FGFR1 FGF6 FGF9 FGF20 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events FURIN RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX ACE2 MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 ANO8 CSNK1A1 PARP14 ANO9 PARP8 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 UBA52 ST6GALNAC3 ST6GALNAC4 TMPRSS2 SRPK2 ANO10 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors CALCRL ADM2 ADM IAPP RAMP1 RAMP2 CALCA RAMP3 CALCB CALCR DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC TCN2 CD320 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle FURIN CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TBP NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 RANGAP1 TAF7L ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A F9 F10 TPST2 TPST1 F8 F2 VWF NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COL4A2 COL4A1 FTH1 SCGB3A2 MASP1 CALR FTL COL1A1 APOA1 COL1A2 APOB APOE COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus BANF1 XRCC6 XRCC4 KPNA1 XRCC5 LIG4 PSIP1 PPIA HMGA1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MKRN1 CDKN1A AKT2 TSC2 MDM2 CDKN1B CHUK AKT1S1 GSK3A AKT1 CASP9 BAD GSK3B AKT3 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones H2BC9 H4C9 H2BC8 H2BC5 H2BC3 SAP30L H2BC1 HDAC1 H2AC20 H2AC1 HDAC3 KDM1A GPS2 ARID4A MBD3 TBL1X GATAD2B GATAD2A SUDS3 NCOR2 CHD3 BRMS1 NCOR1 TBL1XR1 HDAC2 PHF21A H2AC17 H2AC12 CHD4 RCOR1 H2BC18 SAP18 HMG20B HDAC8 MTA2 H2AC25 H2AC21 RBBP4 MTA1 REST ARID4B MTA3 RBBP7 SAP30 H2AC19 H2BC26 H2AC14 H2BC21 HDAC10 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 EGFR CDC37 NRAS PLCG1 NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification SEL1L RPN2 ERLIN1 TUSC3 PDCD1LG2 ERLIN2 B3GNT3 RPN1 SPOP MAGT1 MIB2 RNF185 CCND1 CUL3 VCP OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 DERL3 DERL1 OSTC DERL2 RNF5 ERLEC1 STT3A OS9 STT3B PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B YWHAG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PDCD1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 COPS5 CUL1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN CSPG4 BGN DCN BCAN VCAN CHST14 CSPG5 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function OPN1SW E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 H2BC3 PEX14 H2BC1 HLA-B RNF20 VCP UBE2J2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC UBA52 PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PEX2 UBB UBC RPS27A UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2B UBE2N PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 CRY2 CRY1 CSNK2A1 CSNK2A2 PER2 PPP1CA PER1 PER3 CSNK2B CSNK1D PPP1CB CSNK1E PPP1CC HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT SHH IHH DHH TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling CDC42 DCC NTN1 TRIO NCK1 SRC RAC1 ABLIM1 WASL ABLIM2 PTK2 ABLIM3 DOCK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 HSPG2 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L CD209 SDC4 SDC2 SDC3 CDK8 AGRN TLR3 IRF3 GPC1 IFNAR1 GPC3 MAVS GPC2 GPC5 GPC4 GPC6 RIGI TLR6 ELOB TLR2 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 CD14 BECN1 TLR7 IFIH1 JAK1 TLR4 UBB MED16 BCAP31 MED15 MED17 CREBBP UBC MED12 TYK2 MED14 MED13 RPS27A MED10 STAT2 EP300 CUL5 LY96 MED1 MED30 MED31 MED8 MED4 MED27 MED6 MED26 MED7 H2BC15 MED23 UBE2L6 MED25 IFNA5 HERC5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 HSPD1 TFAP2A NPM1 MYBL2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 APEH RPL7A RPL18A HEMK2 RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 TRMT112 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 CHAC1 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux RXRA CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB APOD APOE TBL1X NCOA1 ABCA1 ABCG8 KDM4A ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 EP300 APOC2 APOC1 AGO1 AGO2 TNRC6A ABCG1 TNRC6B NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors NKX2-5 KAT2B WWTR1 HIPK1 HIPK2 MME NPR1 NPR2 TBX5 NPPC CORIN CES1 GATA4 NPPA CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic PCNA YWHAE EML4 CDCA5 MYBL2 NCAPG YWHAG ARPP19 NCAPH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 CHMP3 CHMP6 CHMP7 CDC7 FBXL18 FBXL7 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH LYN CDKN2B CDK7 MNAT1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 ABL1 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 JAK2 PPP1CB HJURP RFC5 PPP2R2A RFC3 PPME1 GTSE1 RFC4 BORA FKBPL RFC2 FBXW11 OPTN OBI1 HMMR RPA1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B TICRR MCM7 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MYC PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 HAUS8 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 KMT5A HSP90AA1 CDC25C CDKN1C RB1 CDKN1B CCND3 FZR1 CCND2 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX CPAP LIG1 MAX H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 RCC1 H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 GSK3B PHLDA1 AKT3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation UPK1A EPCAM METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids ACSS3 MED19 SLC22A5 ABCB4 MED18 MED11 AGPAT2 SLCO1B1 SLCO1B3 MED9 MED29 MED28 MED22 MED21 THRSP GPAM GAL3ST1 CERK GBA3 CDK19 GBA2 SMPD3 SMPD2 STS SMPD4 MED13L GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLA2G4A SUMF1 B3GNT5 GGT5 B4GALT6 B4GALT5 ASAH1 ASAH2 ABCB11 FUT2 FUT1 UGCG UGT8 ARSL ARSJ GGT1 ARSK VDR PSAP ARSH ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC CYP2C9 NDUFAB1 CYP2C8 CYP2U1 CYP4F2 CARM1 CYP1A2 RAB5A KPNB1 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PIP4K2A NSDHL PIP4K2B LIPI PIP4K2C CYP2D6 LIPH FDXR SULT2A1 MED1 STARD3 BMX ACOT9 STARD4 STARD5 ACOT7 MED8 MECR STARD6 MED4 STARD7 MED6 MED7 RUFY1 CH25H PRKD3 FDX1 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 TIAM2 CYP2E1 FAR2 MTMR3 MTMR8 CGA BDH2 PLA2G3 BDH1 MTMR9 OXCT1 PLA2G5 OXCT2 PLA2G6 HMGCS2 MTMR6 HMGCLL1 MTMR7 AACS HSD11B1 ACAT1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA PTGES3 CYP4F3 NR1D1 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE CYP27B1 TSPO SPHK2 PTGR1 CYP24A1 PTGR2 CYP21A2 CYP2R1 AHRR SAMD8 PIP4P1 ECHS1 SGMS1 SGMS2 UBE2I PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIP5K1C PIAS4 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 INPP5D ABHD4 PIK3CG ABHD3 PIK3R6 INSIG2 PIK3R5 INSIG1 ARF1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 GBA1 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 CSNK2A1 PLA2G12A CERS5 GPX1 CSNK2A2 CERS6 GPX4 FAAH2 TNFRSF21 CERS1 CSNK2B CERS2 PPM1L HSD17B14 TPTE LRP2 CYP3A4 HSD17B11 MMAA MMUT AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 MBOAT1 DDHD2 MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PCCA PITPNB CPNE7 ECI1 PCCB CPNE6 GDE1 ACACB ACSM6 CPNE1 CPNE3 PTGDS MFSD2B ACAD11 SPHK1 ACAD10 MFSD2A SACM1L SLC51A ESRRA SLC51B PISD CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 CDK8 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 MTMR1 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPX2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS CBR1 SMARCD3 PCYT1B PCYT1A STARD3NL PLAAT1 PLAAT3 PLAAT2 CYP7B1 PLAAT5 PLAAT4 AKR1D1 GDPD1 ALOX12B GDPD3 GDPD5 HSD17B7 CYP7A1 ORMDL2 PPP1CC HSD17B1 TXNRD1 ORMDL3 HSD17B2 PIK3CB SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CYP8B1 ETNPPL PLEKHA8 PNPLA3 PTPN13 PNPLA6 VAPB ACAA2 INPPL1 MSMO1 CYP46A1 PLB1 ENPP6 PIK3CA PIK3R3 SBF1 HADH SBF2 PIK3C3 TPTE2 TRIB3 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 THEM4 CHAT PLD4 PLD6 ARNT2 PLD3 NFYA ALDH3B2 NFYB EBP NFYC CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 BMAL1 ACBD6 ACBD4 DGAT2L6 CRLS1 ACSF2 CYP11B2 PI4KA VAC14 PI4K2B PLD2 DEGS1 MTMR10 ALPI MTMR2 DEGS2 MTMR12 PI4KB PIK3C2A ACBD5 TNFAIP8 MTMR4 CYP4A22 MTM1 DBI INPP4A PCTP FIG4 ACOXL INPP4B ABCC3 PLA2G4F PIKFYVE INPP5F ABCC1 PI4K2A PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L ME1 CPT2 POMC MID1IP1 SLC25A20 PPP1CA CPT1B CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT PPP1CB CYP11B1 AKR1C3 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 LDLRAP1 CUBN APOA2 APOA1 PRKACG APOA5 PRKACA PRKACB ANGPTL4 SAR1B MBTPS1 ALB MBTPS2 PLA2G2A SLC27A1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 PRKAA2 PHYH ACOT8 PRKAG2 GNPAT ACOT2 ACOT4 PRKAB2 HACL1 DECR2 HAO2 EPHX2 PPARGC1A AMACR PPARGC1B RAN MAPKAPK2 CROT LBR ABCD1 OCRL BAAT MED16 SLC25A17 MED15 ACOX2 MED17 MED12 EHHADH MED14 MED13 AGPS ACOX3 MED10 TAFAZZIN HSD17B4 MED27 HMGCL MED26 MED23 MED25 MED24 MED20 PPARG CAV1 PPARA SRD5A3 PPARD NUDT7 VAPA CRAT SEC23A HEXB HEXA LTC4S RORA GLB1L3 GLB1L2 GLB1L SEC24B GLB1 SEC24A PLD1 ARSB HADHB HADHA ACADVL CYP17A1 SEC24D SEC24C EP300 MED30 MED31 RXRA INPP5E HDAC3 MOGAT3 MOGAT2 MOGAT1 GPS2 ABHD5 FABP12 RXRB GK3 GK2 LIPE AGMO GPAT2 TBL1X DGAT2 GK NCOA1 ABCA1 DGAT1 FABP9 FABP1 FABP2 FABP3 NR1H2 FABP4 FABP5 NR1H3 GPD2 NCOR2 FABP7 ARNT PNPLA4 PLIN3 NCOR1 PNPLA5 TBL1XR1 LPIN1 FABP6 LPIN2 MGLL SUMO2 LPIN3 PLIN1 PEX11A CD36 NCOA2 NCOA6 NCOA3 CCNC MVD PLIN2 ST6GALNAC5 ST6GALNAC6 PNPLA2 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 CREBBP SP1 NEU1 CHD9 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA TGS1 SREBF1 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGF ERBB2 MEMO1 EGFR RHOA NRG1 DIAPH1 EREG NRG3 NRG4 NRG2 BTC REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins JUP PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 SOX10 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 CDH19 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 SV2C SV2B SV2A VAMP1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 PRKAB2 PRKAA2 ADIPOQ MLXIPL PRKAG2 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression ASAH1 DICER1 TRPM1 PXN SMARCD1 SMARCD2 SMARCD3 SMARCE1 LIG1 GMPR SOX2 AKT2 ATP6V1E1 ATP6V1G1 ATP6V0B ATP6V0E1 DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H TBX2 HINT1 CCND1 ITGA2 SIN3A CDK2 CTNNB1 MET ATP6V1C1 GPR143 TNRC6C MOV10 TFAP2A AGO3 STT3B AGO4 CDH1 AGO1 AGO2 DPF1 TNRC6A TNRC6B DPF2 DPF3 SS18L1 ARID1A ARID1B PPARGC1A PLK1 SS18 SMARCB1 CCNB1 SOX10 SMARCC1 BRCA1 SMARCC2 ACTB ACTL6A GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CCND1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 GSK3B RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 TRMT10C FASTKD2 PRORP MTERF4 ELAC2 TFB1M MRM1 HSD17B10 MRM2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing NFKB2 CTSG RELA IL18 IL1A CASP1 NFKB1 IL1B GSDMD PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B PIWIL2 POLR2C TDRKH POLR2D HSP90AA1 PIWIL1 POLR2E HENMT1 POLR2F ASZ1 POLR2G MAEL POLR2H MOV10L1 POLR2I POLR2J MYBL1 POLR2K TDRD9 POLR2L TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 PIWIL4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation HDAC6 HSBP1 PTGES3 EEF1A1 HSF1 YWHAE RPA3 HSP90AA1 VCP RPA1 HSP90AB1 RPA2 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 OGG1 NEIL1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 CTNNB1 AXIN2 TCF7L2 TCF7L1 MYC LEF1 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle FURIN CCR5 CXCR4 CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 TBP NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 HMGA1 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 LIG1 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 XRCC6 CHMP7 XRCC4 XRCC5 LIG4 RANGAP1 TAF7L FEN1 ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events KNG1 RASGRP2 RASGRP1 NPFFR2 OXTR NPFFR1 RGSL1 GRPR AVPR1B CYSLTR1 EDNRA EDNRB PROK2 PROK1 AVPR1A UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT NTSR1 NTSR2 ITPR1 GPR17 ITPR2 NMB ITPR3 XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN TRPC7 BRS3 GPRC6A GPR132 TRPC6 CCKAR GNRHR TRPC3 FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R MCHR1 P2RY10 P2RY11 LPAR1 GCGR LPAR2 GPR4 LPAR3 GCG LPAR5 MT-RNR2 F2RL1 F2RL2 CHRM3 F2RL3 CHRM1 GPR68 GPR65 CHRM5 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 TRIO MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 PRKCQ PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 RGS16 ADRA1D P2RY6 HTR2A P2RY2 ADRA1B P2RY1 RGS21 ADRA1A CCK HRH1 HCRTR2 HCRTR1 KISS1 HBEGF MAPK7 KALRN GPR143 PTGFR PTGER1 TBXA2R AGT PRKCD PRKCA BTK GRK2 PRKCE GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 FFAR1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARHGEF25 EGFR HRAS PIK3R3 PIK3CA SOS1 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 MGLL DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ DAGLB DGKK DGKI DGKH AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL1A1 COL25A1 COL1A2 COL22A1 COL23A1 COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL20A1 COL4A6 COL6A3 COL21A1 COL9A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COL3A1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 DCP2 MAPK11 PARN EXOSC7 KHSRP EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 FGF20 FGF16 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions OCLN RUNX1 TJP1 CBFB CLDN5 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex PCNA UBA52 WDR48 RAD18 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2B POLE2 POLE3 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACSM6 ECHS1 ACSM3 ACADS HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) STPG4 UHRF1 H2BC9 METTL23 H2AZ2 H4C9 DPPA3 H2BC8 H2BC5 H2BC3 H2BC1 AICDA H2AC20 TET3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KDM5B H2BC12 KDM5A H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 KDM6B H3C15 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6C MOV10 AGO3 AGO4 CD274 AGO1 AGO2 TNRC6A TNRC6B RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G POLR3H POLR2K POLR3K POLR2L POLR1C POLR1D MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation MET HGF SPINT1 HPN SPINT2 HGFAC PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade PIK3R4 PIK3R2 PIK3R1 FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis PARP1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum POFUT1 NOTCH2 NOTCH3 NOTCH1 POGLUT1 NOTCH4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events AKT2 PDE3B POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels GNG13 GNB2 KCNJ8 GNB1 KCNJ11 ABCC8 ABCC9 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNMA1 GNG3 GNG2 GNG5 GNG4 GNG7 KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK1 KCNN2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ2 KCNJ2 KCNQ3 KCNJ3 KCNQ4 KCNJ4 KCNQ5 KCNV1 KCNV2 GABBR2 KCNN1 KCNJ5 KCNN3 KCNN4 KCNJ6 KCNF1 GABBR1 KCNC1 KCNJ10 KCNK9 KCNC2 KCNJ12 KCNC3 KCNJ9 KCNC4 KCND1 KCND2 KCND3 KCNJ15 KCNAB1 KCNJ16 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 KCNK4 HCN1 GNG10 GNG12 GNG11 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction SORBS3 MYL5 MYL7 ITGA1 PXN ITGB5 GUCY1B2 GUCY1B1 TPM4 TPM3 GUCY1A2 GUCY1A1 PDE5A ANXA2 TLN1 VCL TRIM72 DYSF PAK1 LMOD1 MYL6B MYL12B CACNA1H MYL6 MYL12A MYLK CACNA1G MYH11 CACNA1I MYL9 ALDH2 CALD1 PAK2 ANXA6 MYL10 CAV3 TPM2 MYL11 CALM1 TPM1 ANXA1 SORBS1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C OXA1L KGD4 UCP1 NDUFAB1 ACAT1 MT-CO1 BCS1L COX19 COX17 ATP5MC1 SCO2 MT-CO2 MT-CO3 CYC1 CS VDAC1 ACO2 UBA52 HSCB HSPA9 TIMM21 UBB UBC RPS27A SLC25A12 FXN SLC25A13 NDUFB8 ATP5F1A SIRT3 ATP5F1B IDH3G CYCS MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 PC CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D LETM1 MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SLC25A4 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ATP5MK COX11 ATP5MJ COX14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5MF ATP5ME COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 COXFA4 NDUFA6 FAHD1 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 PDK4 NDUFS3 WDR26 PDHB GOT2 RMND5B LDHA MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 ECSIT PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 COX7B GPT COX7C COX8A COX8C DLD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A IK SNRPN PRP4K WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response XIAP CARD8 CYCS UACA MAPK1 AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells FGF10 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K4 IKBKB UBC RPS27A FBXW11 NFKB1 TNIP2 UBA52 BTRC CHUK SKP1 MAP2K1 MAP3K8 IKBKG CUL1 UBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins MUC13 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 MUC1 POMT2 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 POMT1 MUC4 MUC6 POMGNT1 MUC16 GALNT3 B4GAT1 MUC17 C1GALT1 MUC19 DAG1 SSPOP MUC5B LARGE1 MUC20 MUC21 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 SH3GL1 UBA52 STAM STAM2 MET HGS UBB SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 DPH7 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEL1L RAD23B PRKCSH UBA52 RNF185 GANAB PDIA3 VCP EDEM2 MOGS UBB DERL1 UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 UBXN1 PSMC1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects PNP PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway CLTC CLTB FZD2 WNT5B FZD5 FZD7 WNT5A ROR1 FZD4 CLTA ROR2 AP2A1 PRICKLE1 FZD6 RAC2 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 RHOA AP2S1 SMURF2 SMURF1 AP2B1 PSMD8 PSMD6 PSMD7 PSMD2 ARRB2 PSMD3 SCRIB VANGL2 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DAAM1 PFN1 PARD6A ADRM1 PSMC5 PSMC6 RAC1 PRKCB SEM1 PSMC3 DVL1 PSMC4 DVL2 WNT4 PSMC1 DVL3 PSMC2 PRKCG WNT11 FZD3 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOT2 ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B KIF5A NCKIPSD RAP1GDS1 KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 VHL AR CFTR RHOT1 BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 LRRC41 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 CCNE1 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 PLIN3 NCOA2 PTK2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT5 GGT7 GGT6 DPEP2 GGT3P DPEP1 GGT1 ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CYP3A4 CYP1A2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R3B E2F1 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B POLA2 PPP2R1A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin F8 F2 VWF INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 ISL1 GIP DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C GATA4 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO SAE1 SENP5 SUMO3 SENP1 SUMO2 SENP2 UBE2I SUMO1 RWDD3 UBA2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HNRNPC BMI1 SUMO2 RING1 HNRNPK UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 NOP58 CBX2 PHC3 AAAS NUP160 NUP214 POM121C NUP42 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 KLB FGF16 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 ECHS1 ACAT1 MCCC1 PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A CSK RAF1 JAK2 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 IGF2 CTSG IGF1 TF CALU KLK3 KLK2 SERPINA1 MBTPS1 KLK13 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN PLG ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 LAMB2 PDIA6 PAPPA MXRA8 SPARCL1 FN1 IGFALS LAMB1 SCG2 KLK1 LAMC1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 GZMH NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC F2 GAS6 APLP2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling IFNA2 IFNA8 TYK2 IFNA13 IFNA14 IFNA16 STAT2 IFNA17 SOCS3 PTPN6 IFNAR1 IFNA10 IFNA21 IFNB1 JAK1 IFNA5 IFNA4 PTPN1 SOCS1 IFNA7 USP18 IFNA6 PTPN11 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CB RAPGEF1 CRK PIK3CD LYN PIK3R2 CBL PIK3R1 YES1 HCK BLNK SYK FYN PIK3R3 CRKL PIK3CA VAV1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling DPYSL3 FES PLXNA2 PLXNA3 CDK5 FYN PLXNA4 NRP1 CDK5R1 CRMP1 GSK3B DPYSL4 PLXNA1 DPYSL5 SEMA3A DPYSL2 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade SOS1 SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS FGF20 THEM4 MAPK1 FGF23 FGF22 KLB MAPK3 FLT3 IRS1 INSR PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade SERPING1 C3 CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PROS1 F2 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PFKFB1 PRKACA PRKACB MLXIPL ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells UPK1A EPCAM FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation FGF23 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism PNPLA7 PNPLA6 GDPD1 GDPD3 GDPD5 ENPP6 GDE1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3CA PIK3R3 PIK3R5 ICOSLG FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription CITED2 GCK FBXO32 G6PC1 CDKN1A INS HDAC1 NPY NFYA CCNG2 SIN3A NFYB NFYC BCL2L11 PLXNA4 FASLG PCK1 NR3C1 FOXO4 ATXN3 BTG1 DDIT3 TRIM63 STK11 SMAD2 SMAD4 AGRP SMAD3 BCL6 HDAC2 YWHAB TXNIP PINK1 AKT1 YWHAQ YWHAG RBL2 YWHAZ SFN PPARGC1A CAT ABCA6 RETN CDKN1B POMC SOD2 KLF4 CREBBP BBC3 FOXG1 KAT2B FOXO6 PCBP4 FOXO1 EP300 AKT2 IGFBP1 SIRT1 MSTN SIRT3 FOXO3 TXN SREBF1 GADD45A CAV1 AKT3 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex BICRAL ACTL6A BICRA BRD9 SS18 SMARCD1 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SS18L1 ACTB TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation SNAP25 RAB3A SLC32A1 STX1A SYT1 SLC6A13 HSPA8 ABAT SLC6A1 VAMP2 CPLX1 GAD1 RIMS1 GAD2 ALDH5A1 DNAJC5 SLC6A11 SLC6A12 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase OCLN DSG1 DSG3 PLEC ADD1 ROCK1 H1-1 H1-0 H1-3 LMNB1 CTNNB1 TJP1 H1-2 H1-5 H1-4 VIM CLSPN CDH1 SATB1 CASP6 PRKCD APC KPNA1 BIRC2 SPTAN1 DFFB DFFA DBNL ACIN1 KPNB1 GAS2 MAPT BCAP31 GSN TJP2 FNTA DSG2 PKP1 BMX STK24 STK26 HMGB2 HMGB1 PRKCQ CASP8 PAK2 PTK2 CASP7 DNM1L DSP CASP3 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants ALK DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair NEIL3 NEIL1 PMS2 MLH1 MSH2 MSH3 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 MSH6 RMI2 RFC3 RFC4 RMI1 OGG1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A NTHL1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling RELA MAP3K7 IL1RL1 IL33 CTSG MAP2K6 IL1RL2 IL36A IL36B IL1R1 IL36G IL36RN IL1F10 SMAD3 TBK1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 GSDMD USP14 BTRC IL18 NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 PTPN13 HMGB1 CASP8 MAP2K1 UBE2N STAT3 NFKB1 MAPK8 CHUK PTPN11 IKBKB SQSTM1 MYD88 SIGIRR IRAK3 ALOX5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 CASP1 PSMD1 PSMA5 PSMA6 PSMA3 PTPN4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL18RAP IL1R2 PSMD13 IL4 NFKB2 TOLLIP PSMA7 PTPN20 PTPN23 PSMB6 IL18BP IL13 PSMB7 IL1RAPL1 PSMB4 MAP3K3 NKIRAS1 PTPN18 NKIRAS2 PSMB5 IL37 MAP3K8 IKBKG PTPN12 UBB PTPN14 IKBIP RIPK2 PSMB2 PTPN9 MAP2K4 PSMB3 PTPN7 IRAK4 PTPN5 UBC IL18R1 PSMB1 PTPN2 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 PTPN6 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 ELAC2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG ABHD6 ABHD12 DAGLB MGLL DAGLA MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR3 CTSS CNPY3 TLR8 TLR7 CTSB CTSV CTSL LGMN CTSK HSP90B1 TLR9 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 HBS1L EXOSC7 NT5C3B EXOSC6 SKIC2 SKIC3 DCPS EXOSC5 EXOSC4 DIS3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 VCP SHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA PARP1 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 RFC2 RFC1 PARP2 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 PARG APEX1 ADPRS PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria PAH NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways NUP85 TPR KPNA7 NUP62 KPNA4 KPNA5 NUP88 GBP1 NUP43 KPNA3 RAE1 PABPN1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 EIF2AK2 ISG15 NUP37 KPNB1 MLKL KPNA2 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 GP1BA H2AC20 SETD1B SETD1A SIN3A ASH2L TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B NR4A3 MYL9 SIN3B DPY30 WDR5 GATA1 THBS1 RBBP5 PF4 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KAT2B KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 ZFPM1 PRKCQ H2BC11 KMT2A CBFB ITGA2B H3C15 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA CYP26B1 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation AGPAT2 ARPC5 GM2A ACTR2 APEH ARSA FGR ASAH1 PECAM1 RAB9B PSAP MGST1 MME GLA P2RX1 CAT IST1 CD14 GSDMD RETN SPTAN1 DBNL FUCA2 KPNB1 GSN TICAM2 DNAJC3 PKP1 SDCBP RAC1 CST3 HMGB1 DSP DSG1 C3AR1 MAGT1 LTA4H NCSTN ADAM10 PSEN1 CDK13 GOLGA7 C5AR1 ACTR10 HSPA1B DDOST LPCAT1 ALOX5 CD59 CD55 HPSE SNAP25 RAB3A DNAJC5 KRT1 CNN2 TOLLIP ANXA2 MIF PPIA CSNK2B CTSB CDA FRMPD3 RAB14 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 RNASE2 UNC13D FLG2 PADI2 FPR1 CPNE1 GNS CPNE3 PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 VCP FUCA1 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 HMOX2 SIGLEC5 GHDC TMEM179B RAB3D HP EPX SLC44A2 PYCARD RAB44 CR1 GLIPR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B RAB5C STK10 BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 FCAR ALAD FCGR3B ORMDL3 PGM2 ACP3 TCIRG1 SNAP29 PGM1 RNASET2 DYNC1LI1 TNFRSF1B PKM PTGES2 TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC CTSD TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 FAF2 PTPRN2 SIGLEC14 ATP6V0C STK11IP SURF4 PRG2 NBEAL2 PRG3 RHOG DYNLL1 DERA BST2 RHOF BST1 NRAS VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ MAPK1 ACTR1B CTSH CD33 CTSC CD53 ATP6V1D MANBA ALDH3B1 FCER1G GAA NME2 ATP6V0A1 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CD47 DEGS1 CD44 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 CKAP4 OSTF1 CD93 LRRC7 CD300A IRAG2 ATAD3B OSCAR TYROBP DOCK2 DOK3 COPB1 ADGRG3 MOSPD2 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 NAPRT ADGRE3 HGSNAT DYNLT1 ATP6AP2 ARMC8 PLAUR MMP8 MMP9 CHI3L1 PDXK BIN2 CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 RAB27A CEACAM1 LAMP2 PPIE ARG1 AP2A2 A1BG SLC15A4 RAP1B RAP1A CTSG NPC2 PPBP PRSS3 PGLYRP1 PRSS2 CAMP SERPINA3 ORM1 FPR2 SLC11A1 SERPINA1 RNASE3 ORM2 TRPM2 BPI QSOX1 PRTN3 S100A9 CAP1 S100A8 AHSG LTF TLR2 S100A7 CD63 PTAFR DEFA1B ELANE DEFA4 LYZ CAPN1 LCN2 AMPD3 APRT PNP IMPDH1 IMPDH2 EEF1A1 ACLY HLA-H SLC27A2 HLA-B HLA-C HSP90AB1 ACAA1 ATG7 CAB39 B4GALT1 CTSS VAMP8 PSMD6 PSMD7 HUWE1 PSMD2 PSMD3 LAMTOR2 LAMTOR1 PSMD1 LAMTOR3 CYFIP1 IDH1 PRKCD PSMA5 SNAP23 PSMA2 PSMD12 PSMD11 STBD1 PSMD14 CEP290 PSMD13 KCNAB2 TUBB PSMB7 CYBB CYBA PSMB1 RAB7A HSPA8 MAPK14 UBR4 PSMC3 PSMC2 HSPA1A NCKAP1L APAF1 CFD C3 ATP8A1 VAPA ATP11B CCT2 ATP11A ROCK1 ATP8B4 B2M STING1 AP1M1 HEXB GLB1 ARHGAP45 IQGAP1 ANO6 PLD1 GUSB IQGAP2 ARSB HSP90AA1 FRK JUP ARHGAP9 STOM ITGAV FTH1 FTL NDUFC2 XRCC6 XRCC5 NFKB1 ITGAX CHRNB4 ITGAL DGAT1 FABP5 GPI CD36 HK3 PGAM1 LGALS3 CFP ALDOC ALDOA PFKL NEU1 PTPN6 CTSA S100A12 EEF2 MLEC TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP PML UBC PTEN RPS27A NEDD4 USP7 UBA52 UBB MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins MET TNS4 TNS3 HGF ITGB1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling HBEGF EGF ERBB2 PIK3R1 EGFR NRG1 GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion PDS5B SMC1A SMC3 PDS5A WAPL STAG1 STAG2 ESCO1 RAD21 ESCO2 CDCA5 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation UGT2B7 UGT1A3 SLC35D1 SLC35D2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT1A9 UGT2B17 UGDH UGT2B4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CX3CR1 CCL3L3 CXCR5 CCR5 CXCR6 CXCR4 CCL7 CCR6 CCL5 CXCR3 PPBP CCL4 CCL3 CCL2 CCL1 CCL19 CCR2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 CXCL10 CXCR1 CXCL11 CXCL12 CXCR2 ACKR4 ACKR3 ACKR2 XCR1 CCL28 CCL27 CXCL1 PF4 XCL2 XCL1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism SERINC4 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 LBP CD14 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse LYN NGEF YES1 RHOA ROCK1 MYL12B FYN ROCK2 MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2S1 AP2A1 AP1G1 AP1S2 AP1S1 AP2A2 AP1S3 B2M AP1M2 AP2B1 AP1M1 AP1B1 HLA-A AP2M1 ARF1 CD8B PACS1 ATP6V1H LCK CD28 CD4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events NTRK1 KIDINS220 RAPGEF1 CRK NGF YWHAB MAPK1 RAP1A FRS2 MAP2K1 MAP2K2 CRKL MAPK3 BRAF NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR FLT1 NRP2 KDR NRP1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer PRF1 ICOS STAT5A IL10RA ZC3HC1 STAT3 CCNB1 HDAC1 NPM1 GZMB RB1 MAPK1 CEBPB MAPK3 DNMT1 FOXM1 TNRC6C MOV10 AGO3 AGO4 JUNB PTPN6 AGO1 AGO2 RPS6 IRF4 BCL2A1 SKP1 RBX1 TWIST1 ZAP70 CUL1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX4 ALOX12B ALOX15 ALOX12 GPX2 GPX1 ALOXE3 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) CYP51A1 EBP LBR DHCR7 MSMO1 NSDHL HSD17B7 TM7SF2 SC5D DHCR24 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules VASP ITK TRAC CD3G CD3E CD3D PLCG1 TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 EVL HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 NCK1 WAS PAK1 PAK3 LCK PLCG2 PAK2 ZAP70 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CACNA1D CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) RPS6KA1 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 SGK1 MAPK1 NAB1 NAB2 LYL1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 PPP2CA EGR3 PPP2CB JUND EGR4 FOSL1 ID2 ID1 MEF2C CDK5 ID4 FOSB ID3 CDK5R2 TCF12 CHD4 MAPKAPK2 REST ATF1 PPP2R1B PPP2R1A SH3GL3 VGF EP300 JUNB MAPK14 MAPK11 MEF2D FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs NEDD4L STUB1 ITGB8 ITGB5 FURIN PMEPA1 CBL BAMBI STRAP UBA52 TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 PPP1CA USP15 ITGA8 PPP1R15A PPP1CB PPP1CC TGFB2 UBB TGFB3 UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD4 SMAD3 SMURF2 SMAD7 SMURF1 NEDD8 TGFBR3 FKBP1A XPO1 LTBP4 ITGB3 ITGB1 LTBP3 LTBP1 ITGAV DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG1 UBC RPS27A RNF41 ERBB2 USP8 AKT1 AKT2 UBA52 NRG2 UBB AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors OXTR OXT AVPR1B AVP AVPR2 AVPR1A EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP8B1 TBXAS1 CYP4F3 CYP4A22 CYP4B1 CYP4F8 CYP4F2 CYP4A11 PTGIS CYP4F12 CYP4F22 CYP4F11 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment IKBKB RIPK1 UBC UBE2D1 TICAM1 RPS27A TLR3 UBE2V1 TRAF6 UBA52 BIRC2 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense SFN FNTA GBP1 FURIN GBP5 PIM1 PGGT1B GBP2 FNTB GBP4 GBP3 CASP1 ACTG1 ACTB PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 HEXB NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 RRP8 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 SUV39H1 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 SIRT1 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes PCBP4 TP53 CDKN1A ZNF385A RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 TEAD3 TEAD4 CCN2 RUNX3 WWTR1 TEAD1 TEAD2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity UBC PTPN2 SH3KBP1 RPS27A SH3GL3 EPS15 USP8 CBL SH3GL2 SH3GL1 UBA52 STAM PTPRJ LRIG1 STAM2 MET HGS HGF PTPN1 UBB NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 UBC RPS27A CBL UBA52 PTPRJ SLA ABL2 CSK SLA2 SOCS2 SOCS6 FLT3LG SH2B3 FLT3 UBB FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER CCNH RAD23A RAD23B PARP1 CETN2 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A DDB2 PIAS3 SUMO3 SUMO2 PARP2 USP45 UBE2I RPA1 PIAS1 RNF111 CHD1L SUMO1 RPA2 DDB1 UBE2V2 XPA XPC CUL4A RPA3 RBX1 ERCC4 ERCC1 UBE2N ERCC5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TICAM2 TICAM1 RIPK3 CASP8 LY96 FADD CD14 TLR4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 SLBP CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 PTPN12 NRG2 BTC TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation GP5 SERPINA5 GP9 SERPING1 A2M KLKB1 PRCP GP1BA KNG1 SERPINC1 C1QBP F9 PROC F10 SERPIND1 PROS1 F8 F2 VWF SERPINE2 GP1BB F12 F11 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions BAG4 FGFR1 ERLIN2 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling EPHB6 EFNB2 NCK2 EFNB1 ARHGEF7 EFNB3 EPHB2 EPHB1 SDCBP EPHB4 EPHB3 PAK1 PAK3 RAC1 FYN MYL12A GIT1 PAK2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation RIPK1 TICAM2 TRAF2 TNFRSF10B TICAM1 TNFSF10 TNFRSF10A LY96 FADD CD14 TRADD FAS FASLG CASP8 TLR4 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 ERBIN PRKCA SOS1 PTK6 STUB1 HBEGF SHC1 HSP90AA1 ERBB2 EGF USP8 PIK3R1 EGFR MEMO1 CDC37 NRAS PLCG1 UBA52 MATK RHOA PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 SRC YES1 HRAS NRG1 FYN GAB1 PRKCE DIAPH1 GRB7 AKT1 EREG NRG3 PIK3CA NRG4 NRG2 BTC AKT3 PRKCD DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN IL10 YES1 HCK SYK AHCYL1 FYN FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen GP5 GP9 ITGA1 LYN GP1BA GP6 ITGA10 FYN ITGA2 ADAMTS13 FCER1G VWF ITGB1 GP1BB PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs PAPOLA SYMPK NCBP1 CSTF2T NCBP2 CLP1 FIP1L1 PABPN1 CPSF4 CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 PCF11 CPSF2 CSTF2 WDR33 CSTF1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors NR1H2 NR5A1 RXRA PIAS4 NR2C1 PIAS3 ESR1 SUMO3 SUMO2 UBE2I VDR PIAS1 HDAC4 NR4A2 SUMO1 NR3C2 THRB RORA RARA NR3C1 PGR PPARG AR PPARA DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K POLR2L GTF2H1 CAVIN1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 TTF1 ERCC3 ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations DAG1 POMT2 POMT1 POMGNT1 MGAT5B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation NFATC2 AHCYL1 NFATC3 PPP3CA PPP3CB NFATC1 ITPR1 ITPR2 ITPR3 PPP3R1 CALM1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 CYSLTR1 CYSLTR2 DPEP1 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PTK6 CDKN1A CDC25B CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 FZR1 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT4 WNT3A LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WIF1 SOST TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand LBP CD36 LY96 TLR1 CD14 GSDMD GSDME S100A9 APOB TLR6 S100A8 TLR2 TLR7 FGB HMGB1 S100A1 FGA FGG TLR4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport ABCB6 ABCB4 SEL1L KCNJ11 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 VCP ABCC2 ABCG8 ABCC6 EIF2S2 EIF2S1 EIF2S3 ABCG5 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 ABCA3 ABCC3 ABCC1 ABCG1 ABCD3 PSMD8 PSMD6 ABCC4 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 ABCD2 ABCA6 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 ABCC5 PEX3 UBC ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 SEM1 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 ABCA12 PEX19 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 GFPT1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 CILP PIK3CA TLR9 PIK3C3 TRIB3 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly SERPINB1 CASP4 CALM3 CALM2 CALM1 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand TLR7 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin FDX1 FDX2 FDXR HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM5D PHF8 UTY KDM4B H4C9 KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 KDM7A KDM3A KDM1A KDM1B KDM4A KDM4C H3C8 KDM5B KDM5A KDM6A PHF2 KDM6B KDM5C KDM3B H3C15 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 FZR1 PLK1 FBXO5 CCNB1 CDC20 CDK1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle CLTC IQGAP1 SH3RF1 VANGL1 ARHGEF7 PIK3R1 RHOV MAP3K11 SPTAN1 MYO9A TPM4 GIT1 TPM3 TXNL1 WASL ARHGAP12 CDC42 DEPDC1B ZNF512B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 PARD6B PAK6 PAK1 CCP110 CEP97 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle DSG1 VANGL1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 ROCK1 TMOD3 TXNL1 PKP4 DDX4 RASAL2 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B EPHA2 WDR6 DST UBXN11 DLG5 PICALM ARHGAP21 TNFAIP1 SEMA4F PTPN13 RND3 NISCH KTN1 CKB CKAP4 PLEKHG5 KCTD13 SCRIB VANGL2 FLOT2 DSP CAV1 CCDC88A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 GPAM MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab ERBIN HSP90AA1 ERBB2 CDC37 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP3 CHMP6 CHMP7 TUBB8 IST1 TUBA8 TUBA1C LEMD2 TUBA1B TUBB8B TUBA1A TUBB2B TUBB2A SPAST CC2D1B TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D CHMP4C TUBA3C CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A TUBB4B TUBB4A SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 CSF1R SHC1 LYN STAT3 CBL INPP5D PIK3R1 IL34 UBA52 GAB3 GRAP2 STAT1 KRAS UBB PTPN11 PIK3CB UBC RPS27A PIK3CD THOC5 SRC YES1 HCK FYN INPPL1 PLCG2 GAB2 PIK3CA CSF1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 BBS2 BBS1 CCT2 CCT8 RAB3IP CCT5 BBIP1 BBS9 CCT4 BBS7 CCT3 TTC8 BBS5 BBS4 MKKS SMO TCP1 SSTR3 LZTFL1 BBS10 BBS12 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACSM6 HADHB MECR ACADL HADHA ACADVL ECHS1 ACADM ACSM3 ACADS HADH SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 HDAC1 NEURL1B DNER HES5 TLE4 APH1A TLE2 HDAC3 DLL4 MIB2 ITCH PSENEN TLE1 DTX1 NCSTN MIB1 DTX2 APH1B HEYL PSEN2 DLK1 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 DTX4 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 ARRB1 RBX1 ARRB2 HIF1A HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 NUMB HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NBEA NOTCH1 CUL1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib ERBIN HSP90AA1 ERBB2 CDC37 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FPGT FCSK GFUS FUOM MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) MYD88 TLR5 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5E NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation FGF19 FGF18 FGFR4 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 KLB FGF20 FGF16 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG1 HRAS SOS1 HBEGF SHC1 NRAS NRG3 EREG NRG4 BTC NRG2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CDKN1A CDKN1B ARID3A E2F1 CDK2 E2F7 E2F8 CCNA2 TP53 CCNA1 CCNE2 CCNE1 ZNF385A CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling RELA NFATC1 MAP3K7 NFKB1 UBA3 UBE2M CDC34 NFATC2 CHUK IKBKB CARD11 MALT1 ITPR1 RELB ITPR2 CLEC7A ITPR3 CARD9 NFKBIA MAP3K14 TAB1 UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PLCG2 PSMD3 PSMD1 CALM1 PYCARD PRKCD PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 TRAF6 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 NFKB2 PSMB6 PSMB7 IL1B PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB TAB3 SKP1 PDPK1 TAB2 CASP8 PPP3R1 UBE2N CUL1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UXS1 UGDH UGP2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events GNAQ ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 GNAT3 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 CAMK2A GNAI3 GNAI1 GNAI2 CALM1 CAMK2G PRKCD PRKCA PLCB4 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 NBEA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle ERBIN ARHGAP26 ARHGEF3 VANGL1 ARHGEF1 ARHGAP32 ARHGEF2 PIK3R2 ARHGEF5 PIK3R1 RHOB ROCK1 CAVIN1 ROCK2 MYO9A ABR RTKN ECT2 ARHGEF28 MCF2 NET1 RHPN2 ARHGDIG SOWAHC STARD8 CIT ARHGEF25 PKN3 TFRC IQGAP3 SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 STOM MCF2L RACGAP1 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis FUT2 FUT1 ABO NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAP2K1 MAP2K2 MAPK3 BRAF DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type MMAB SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors SCARF1 APOB CALR HSP90AA1 HSPH1 HYOU1 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways HBEGF GBP1 FURIN HSP90AB1 HBB ATP6V1H MAPK1 STAM2 CTSG CTNNB1 MET RNF213 MAPK3 STX1A B2M CDH1 MRC1 SRC GBP2 UBE2D2 GBP6 GBP4 HBA2 STX1B NOS2 CBLL1 LTF TLR2 GUCY2C SYT2 NHERF4 GSK3A CALM1 ENO1 SNAP25 SH3KBP1 TRIM27 HSP90AA1 KPNA1 SYT1 CD9 CBL CTNND1 UBA52 STAM DUSP16 VPS33B CORO1A PGK1 HGS RAB5A KPNB1 SV2C SV2B SV2A VAMP1 UBB TXNRD1 MAP2K4 UBC RAB7A RPS27A SH3GL3 UPK1A EPCAM EPS15 SH3GL2 SH3GL1 SFPQ VAMP2 MAP2K7 EEF2 CASP4 MAP2K1 MAP2K2 CALM3 CALM2 PDCD6IP MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB RABGGTA NDRG1 BCL6 PERP TP53I3 BIRC5 TP63 TP73 PPP1R13B TP53 TP53BP2 BCL2L14 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE MTR MTRR SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 PI4KA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K7 FURIN MAP2K1 MAP2K2 CALM1 PDCD6IP CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle PCNA NPM1 YWHAE EML4 YWHAQ CDCA5 MYBL2 NCAPG YWHAG ARPP19 ZNF385A NCAPH YWHAH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A UBE2V2 PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 UBE2N CHMP3 CHMP6 CHMP7 PLK3 CDC7 HSPA2 FBXL18 FBXL7 PHF20 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH PIAS4 POLR2A POLR2B POLR2C POLR2D BRCC3 LYN POLR2E POLR2F POLR2G POLR2H CDKN2B POLR2I POLR2J POLR2K POLR2L BABAM1 CDK7 BABAM2 MNAT1 UIMC1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 RUVBL1 ABL1 WRAP53 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E CLSPN NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 MDM2 MDM4 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 ABRAXAS1 NUP37 ERCC6L RBBP7 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 CHEK2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MLH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 JAK2 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 PPP1CB CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 HJURP RFC5 RMI2 PPP2R2A RFC3 PPME1 GTSE1 RFC4 RMI1 BORA TERT FKBPL RFC2 FBXW11 OPTN TOP3A OBI1 HMMR RPA1 HUS1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B RAD50 TICRR MCM7 RAD51 MCM8 RAD51C GMNN RPA3 RAD17 SKP1 RAD1 CCNA2 ATM CCNA1 MCM3 DNA2 RAD9B MCM4 RHNO1 MCM5 MCM6 ATR RAD9A MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 FKBP6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B HERC2 PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MDC1 MYC YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 PIF1 FIGNL1 GAR1 CTC1 KMT5A TEX12 TEX15 RNF168 NSD2 CENPW CENPX RUVBL2 OIP5 MSH4 MSH5 HSP90AA1 NHP2 ANKRD28 NOP10 SYCP2 CDC25C SYCP1 CDKN1C SYNE2 RB1 SYNE1 CDKN1B PPP6C PPP6R3 CCND3 SMC1B FZR1 MND1 CCND2 E2F1 REC8 E2F2 SYCP3 E2F3 RTEL1 SKP2 CHTF8 DAXX TP53BP1 ATRX STAG3 CDK6 RSF1 TFDP1 DMC1 PSMC3IP CCNE2 TFDP2 MLH3 CDK4 MIS18A NEK11 CCNE1 H2AX PRDM9 DSCC1 SHQ1 CPAP LIG1 DKC1 MAX H2AB1 SYCE3 H2AC19 SYCE2 POLD3 COP1 H2BC26 POLD4 H2AC14 SYCE1 POLD1 H2BC12L SPO11 POLD2 RCC1 CHTF18 H2BC21 SUN2 EP300 SUN1 RNF8 H3-3B STN1 H3C8 TEN1 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 SMARCA5 GSK3B CSNK1A1 PHLDA1 PCBP4 AKT3 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP ZNF141 HDAC1 ZNF382 H2AC20 ZNF547 ZNF418 ZNF224 MBD3 ZNF354A ZNF136 ZNF649 GATAD2B GATAD2A CHD3 SUMO2 UBE2I ZNF778 HDAC2 ZNF454 ZNF28 CBX5 CHD4 ZNF273 SETDB1 ZNF816 ZNF519 ZNF610 ZNF264 ZNF680 TRIM28 MTA2 ZNF30 ZNF257 RBBP4 MTA1 ZNF33A MTA3 RBBP7 ZNF331 H2AX ZNF93 H2AB1 H2AC19 H2BC26 ZNF708 H2AC14 H2BC12L H2BC21 ZNF324 ZNF534 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ZNF320 H2BC17 H2BC12 H2BC13 ZNF669 ZNF765 H2BC14 H2AJ H2BC15 ZNF317 H2BC11 ZNF425 H3C15 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism TCN2 CD320 MCCC2 BTD ACACA PC PCCA HLCS CUBN CBLIF MMAB MCCC1 AMN PCCB MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 PABPN1 EIF4E PAIP1 EIF4B EIF4A3 PABPC1 DIS3L2 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH PECR SLC25A17 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A6 SLC12A3 SLC12A1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 SNU13 DCAF13 NOP14 UTP6 UTP4 KRR1 UTP3 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP2 TRMT112 NOP56 NOP58 GAR1 NHP2 NOP10 RPS14 DKC1 RPS2 RPS9 RPS7 RPS6 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FURIN H2BC1 INS H2AC20 APH1A PSENEN APOA1 NCSTN APOA4 APH1B HSPG2 ADAM10 APOE NPPA SIAH1 PRL CALB1 NAT8B BACE1 APCS TSPAN33 B2M GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI LTF ITM2B UBA52 SIAH2 LYZ FGA CALCA H2AX UBB GSN SEMG1 H2AB1 UBC H2AC19 IAPP H2BC26 H2AC14 RPS27A H2BC12L H2BC21 PRKN TTR H3-3B H3C8 H2AC8 MFGE8 H2AC6 H2AC7 TSPAN14 H2BC17 APP H2BC12 H2BC13 H2BC14 CST3 SAA1 H2BC15 USP9X H2BC11 UBE2L6 H3C15 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB NBEA CALM1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation RELA MAP3K7 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 CARD11 IGKV2D-28 MALT1 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 TRPC1 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK IGLC1 BTRC IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PRKCB HRAS PPP3CA PPP3CB PPP3R1 VAV1 SOS1 NFATC1 PIK3R1 NFKB1 NRAS NFATC2 CHUK CD19 IKBKB FKBP1A PSMD8 PSMD6 PSMD7 DAPP1 RASGRP3 PSMD2 REL NFKBIE PSMD3 CD22 PIK3AP1 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD FBXW11 PTPN6 ADRM1 PPIA PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation IFNA2 IFNA8 TRAF2 IFNA13 IFNA14 IFNA16 IFNA17 TRAF6 IFNA10 IFNA21 IFNB1 IFIH1 TRIM4 CREBBP TBK1 EP300 IRF3 MAVS RNF135 RIGI TRIM25 IKBKE IRF7 IFNA5 TANK SIKE1 IFNA4 IFNA7 IFNA6 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t PGM1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis HSD3B2 HSD3B1 CGA LHB CYP21A2 CYP11B2 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 HHAT VCP IHH SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 DTX4 TBK1 NFKB1 IRF3 NFKBIA NLRP4 DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling IL21R LGALS9 SOS1 HAVCR2 IL15RA PTK2B STAT5A STAT5B IL15 SHC1 IL5 STAT3 IL3RA PIK3R2 INPP5D IL2RB SOS2 PIK3R1 IL9 GRB2 IL9R JAK3 STAT4 JAK2 JAK1 IL2RG STAT1 CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 SYK LCK INPPL1 GAB2 PIK3R3 PIK3CA IL21 IL2RA IL5RA CSF2RB CSF2RA METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins VKORC1L1 UBIAD1 LRP1 RETSAT APOA2 APOM APOA1 TTPA BCO2 APOA4 BCO1 HSPG2 VKORC1 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation LCK AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 ARF1 CD4 ATP6V1H ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors GRIN3A APBA1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D KIF17 GRIN1 DLG1 GRIN2A CASK LIN7A DLG2 LIN7C NBEA DLG3 LRRC7 LIN7B DLG4 NEFL CAMK2G GRIN3B DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation UHRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 DNMT3L H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DBT DLD DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis NCAN CHST15 CSPG4 BGN DCN BCAN VCAN DSEL CHST14 DSE UST CSPG5 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 KPNA2 H2BC15 TP53 H2BC11 ATM UBE2N PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CDK2 CCNE2 RB1 CCNE1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration ITGA5 ITGBL1 MMP13 AKT1 AKT2 CBFB AKT3 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry AGRN FURIN NCL EGFR GPC1 LY96 GPC3 GPC2 CD14 GPC5 RAB5B GPC4 RAB5C GPC6 CX3CR1 HSPG2 IGF1R SDC1 RAB5A SDC4 SDC2 SDC3 TLR4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED19 MED18 SREBF2 MED11 WNT1 RELA MED9 MED29 MED28 MED22 TGFB1 MED21 CDK19 MBD3 MED13L ANGPTL4 LPL GATAD2B GATAD2A CDK8 SMAD1 SMAD4 LEP CHD4 CIDEA SMARCD3 CCND3 MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MTA3 CARM1 EBF2 RBBP7 BMP7 CDK4 KLF4 EP300 MED1 MED30 MED31 MED8 MED4 MED6 MED7 ELOVL3 CEBPA HNRNPU RXRA NFKB1 HDAC1 KLF5 HDAC3 CEBPB TBL1X PCK1 NCOA1 EGR2 FABP4 NCOR2 COX7A1 CHD3 NCOR1 TBL1XR1 PLIN1 HDAC2 THRAP3 FAM120B PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC ADIPOQ HELZ2 MED16 MED15 CREBBP MED17 CHD9 MED12 MED14 MED13 TNF MED10 EBF1 WNT10B NR2F2 ADIRF SLC2A4 ZNF638 TGS1 CEBPD ZNF467 MED27 MED26 MED23 MED25 MED24 MED20 PPARG PPARA DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction SOS1 CRK STAT5A STAT5B STAT3 PIK3R2 PIK3R1 PDGFB NRAS PLCG1 STAT1 PTPN11 PIK3CB RAPGEF1 NCK2 NCK1 RASA1 SRC PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling JUN GNG13 ZNF217 FKBP5 EBAG9 GNB2 KDM4B YY1 GNB1 GNB4 DDX5 GNB3 GNB5 GNGT1 GPAM GNGT2 SPHK1 GNG3 CXCL12 ESR1 GNG2 GNG5 GNG4 GNG7 GNG8 POU2F1 NOS3 TBP HSP90AA1 EGF EGFR CDKN1B S1PR3 CARM1 H2AX H2AB1 H2AC19 MMP2 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 MED1 H2AC8 PRKCZ H2AC6 CTSD H2AC7 HRAS H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 MMP3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 PIK3R3 PIK3CA CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 HBEGF H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 HDAC1 NRAS H2AC20 HSP90AB1 KDM1A MAPK1 GNAT3 CCND1 PTGES3 NRIP1 FKBP4 NCOA1 SRF MAPK3 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 ESR2 AGO2 SRC TNRC6A TNRC6B GNAI3 XPO1 GNAI1 GNAI2 AKT1 CALM1 AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 MMP9 KANK1 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG KAT2B FOXA1 ZDHHC7 TLE3 KPNA2 PPID TGFA USF1 CAV2 FOS FOXO3 GREB1 ELK1 IGF1R GNG10 CHD1 PTK2 MMP7 EREG PGR TFF3 UHMK1 TFF1 BTC ZDHHC21 CAV1 GNG12 CXXC5 EPGN AKT3 GNG11 USF2 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors HRH3 HRH2 HRH4 HRH1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters SLC24A2 SLC24A3 SLC41A2 SLC41A1 SLC30A10 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 CP SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC40A1 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC8A1 SLC8B1 SLC24A1 SLC8A2 HEPH SLC24A4 SLC11A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SRI SLC9A8 SLC9A9 SLC9A1 SLC24A5 SLC39A4 SLC8A3 SLC11A2 CALM1 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation POLE4 POLE POLE2 PRIM2 POLE3 PRIM1 POLA1 POLA2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 CAVIN1 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules LRFN1 PTPRS PTPRF GRIA1 GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG3 RTN3 DLG4 FLOT1 LRFN3 FLOT2 PTPRD GRIA3 LRFN2 GRIA4 LRFN4 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA PLA2G2D MIGA1 PLD1 PLA2G2E DDHD2 AGPAT2 PLA2G5 DDHD1 PLA2R1 PLA2G10 GPD1 GPD1L PLD6 GPAM PLA2G2A GPAT2 LPCAT1 PLA2G4A PLD2 ALPI GPD2 GNPAT LIPI ACP6 LIPH PLA2G12A PLA2G4D GPAT4 PLA2G4B GPAT3 AGPAT5 PLA2G1B LPCAT4 AGPAT1 AGPAT3 AGPAT4 LCLAT1 PLA2G2F MIGA2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism ACSL1 FADS1 ELOVL5 ELOVL2 ABCD1 ELOVL3 ELOVL1 FADS2 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity HTT HDAC1 HDAC3 GPS2 SIN3A LBR HIPK2 PRKACA TBL1X AURKB FOXG1 NCOR2 TNRC6C MOV10 NCOR1 AGO3 TBL1XR1 AGO4 CAMK2B AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A CAMK4 CALM1 CAMK2G SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections IFNA2 IFNA8 RELA IFNA13 IFNA14 IFNA16 SAP30L IFNA17 NPM1 ITCH IFNA10 IFNA21 IFNB1 ISG15 NR3C1 PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP YWHAE VPS41 NPIPB3 VPS45 NMI PARP10 PARP6 SFTPD CHD4 IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 MTA2 VPS33B RIPK3 REST KPNB1 FNTA CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A VAV1 UBE2N CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 PTGES3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 FKBP4 OST4 EDEM2 MOGS SDC4 ZDHHC11 IFNGR1 DDOST SDC2 IFNGR2 MGAT4C SDC3 ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 SUMO1 GPC5 GPC4 GPC6 KEAP1 RBX1 TRIM25 SDC1 VHL ISCU BTK IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TLR8 KPNA2 MAP3K7 VCP NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA MAVS TAB1 GJA1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C PYCARD NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 TRAF3 RANBP2 TRAF6 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 BECN1 NUP50 NUP35 RBBP4 NUP54 NUP37 NOD1 RBBP7 NOD2 NCK1 AKT2 PDPK1 RPS27 ITGB1 TLR9 PIK3C3 SOS1 SNRPD2 SNRPD1 SNRPD3 PIK3R4 BST2 PRMT1 CHUK TJP1 PCBP2 PTPN11 CASP1 JAK2 ZCRB1 SYK SNRPG SNRPE PPIH PPIG SNRPF AP2A1 SNRPB AP2A2 DDX5 AP2M1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 SAR1B IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 TLR1 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 TLR2 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 SAP18 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 IGLC2 S1PR1 JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 IGLV3-19 MTA3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 RPS4Y1 IGLV3-1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 RPS17 IGKC RPS15A IGKV1-39 IGLV3-21 RPS16 RPS19 IGKV1-33 BRD4 RPS18 RPS3 CRBN RPS2 IGLC7 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 RPS13 IGLC6 RPS12 IGKV1-5 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 PDCD1 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 HLA-H HLA-B HLA-C ATG14 HDAC1 HLA-F HSP90AB1 HLA-G HLA-E YWHAB FKBP1A IKBKE AKT1 IRF7 NUP214 SFN YWHAZ UBA52 TUBB UBB UBC RPS27A UBE2V1 PSMC6 CAV1 FURIN ATP1B3 ROCK1 ATP1B2 ROCK2 ATP1B1 CUL3 MBD3 STAT1 GATAD2B GATAD2A ZBP1 SEC23A TBK1 B2M IRF3 STING1 HLA-A FXYD4 FXYD3 FXYD2 FXYD1 PALS1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 UVRAG ANO5 MAP1LC3B ANO2 ANO3 HSP90AA1 ANO1 RB1 ATP1A4 ATP1A3 ATP1A2 FNTB SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 EP300 IL6R RUNX1 NRP1 MASP1 NFKB1 SRPK1 KDM1A HSPG2 ITGA4 AGRN CHD3 HDAC2 ST6GALNAC2 SIKE1 GSK3B CSNK1A1 ST6GAL1 ST6GALNAC3 ST6GALNAC4 ARID4B SAP30 CREBBP SP1 ST3GAL4 NFE2L2 BCL2L1 ST3GAL1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 TAB3 TAB2 CTSL IFNA5 IFNA4 IFNA7 IFNA6 AKT3 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib ERBIN HSP90AA1 ERBB2 CDC37 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines STAT6 TBK1 STING1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A GALNS BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins KPNA7 KPNA4 KPNA5 KPNA3 RPN2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 SPCS2 PRKG2 SPCS1 OST4 SEC11A SEC11C DDOST TMEM258 DAD1 OSTC CANX CALR ACOT2 STT3A STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 KPNA1 IPO7 DNAJB11 P4HA1 UBA52 P4HA2 P4HA3 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UBB UBC DNAJC3 RPS27A KPNA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling CAP1 ABL2 CLASP1 CLASP2 SLIT2 ABL1 ROBO1 CAP2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 LEF1 SOX10 SMARCC1 CTNNB1 SMARCC2 GPR143 ACTB SMARCE1 ACTL6A SYTL2 PMEL TFAP2A MYO5A RAB27A TYR AKT2 MYRIP MAPK14 DPF1 BCL7A DPF2 DCT BCL7C IRF4 BCL7B DPF3 SMARCA2 SMARCA4 TYRP1 MLANA USF1 MLPH SS18L1 ARID1A ARID1B ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs PRKAG3 CAMKK2 PRKAB2 PRKAA1 PRKAA2 CALM1 PRKAG1 PRKAB1 PRKAG2 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 TXNRD1 RPS17 SARS1 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A PAPSS2 RPL6 PAPSS1 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 EPRS1 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2A UBE2C UBE2L3 UBE2E1 UBE2D1 UBE2W USP7 USP5 UBE2S UBA52 UBA1 UBE2K UBE2Z CDC34 UBE2Q2 UBE2E3 UBB UBE2R2 UBC UCHL3 RPS27A UBE2T OTULIN UBA6 UBE2D2 USP9X UBE2H UBE2G1 UBE2G2 UBE2B PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds CYB5B CYP51A1 CYP4B1 CYB5R3 CES3 CYP27A1 CYP39A1 CYP3A5 AOC1 CYP2A13 CES1 FMO3 CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP7A1 CYP1B1 CYP2C19 CYP2D6 CMBL ALDH3A1 FDXR POR CES2 MAOB MTARC2 MAOA CYP8B1 MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP46A1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 RXRA ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 ARNT2 PTGES3 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR CYP4F12 PTGIS PTGS1 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP4F11 AIP CYP11B1 TBXAS1 ADH1C ADH1A ADH4 PAOX ALDH1A1 ALDH2 CYP3A4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR2 TGFB1 TGFBR1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) GP5 SOS1 GP9 CRK SHC1 MPL FN1 GP1BA THPO RASGRP2 RASGRP1 RAP1B RAP1A CSK ADRA2C FGB ADRA2B RAPGEF3 FGA ADRA2A RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 F2 AKT1 PTK2 ITGB3 ITGA2B GP1BB SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R HRAS SOS1 IGF2 IGF1 IGF1R NRAS GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 TJP1 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose DPM3 DPM1 DPM2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH JUN SEL1L WWC1 NEURL1B DLGAP5 HES5 PTCRA MIB2 ITCH PBX1 MIB1 HEYL ATP2A3 NEURL1 TACC3 MAMLD1 ATP2A2 ATP2A1 YBX1 ELANE NUMB PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC MAML2 NOTCH2NLB MAML1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC1 GZMB APH1A DLL4 PSENEN NCSTN APH1B CCND1 PSEN2 ADAM10 PSEN1 RBPJ TMED2 FCER2 TNRC6C MOV10 RFNG MFNG AGO3 B4GALT1 MDK AGO4 ACTA2 MYC AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 HIF1A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 KAT2B KAT2A HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 NBEA FURIN DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 STAT1 CDK8 SMAD3 DTX4 JAG2 ADAM17 ARRB1 ARRB2 WWP2 EGF EGFR HDAC5 PLXND1 HDAC8 HDAC9 HDAC6 HDAC7 E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 HDAC10 EP300 HDAC11 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 TBL1X NCOR2 FABP7 NCOR1 TBL1XR1 SNW1 HDAC4 HDAC2 FLT4 HES1 CCNC CREBBP ST3GAL4 LFNG ST3GAL6 JAG1 ST3GAL3 SEM1 DLL1 SKP1 CUL1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA NGFR LINGO1 NGF MAG OMG RTN4 MCF2 RHOA DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis JUN PRDX2 PRDX1 CDK5 CDC25C CDKN2A CDC25B CDC25A C1QBP APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 TP53 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) RPS6KA1 CLTC CLTA AP2A1 AP2A2 NGF AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB VGF EP300 JUNB HRAS FRS2 MAP2K1 CRKL MAP2K2 PIK3CA SOS1 DUSP4 DUSP3 VRK3 DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 ADCYAP1 ADCYAP1R1 YWHAB SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA ATF1 BRAF MAP2K5 RAPGEF1 MAPKAPK3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTRK2 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin KLF4 INS GCG PCSK1 BCHE IGF1 SPCS3 SPCS2 LEP SPCS1 SEC11A UCN SEC11C ACHE MBOAT4 PLA2G7 CRHR2 GH1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation BTRC DDB1 COPS7B COPS7A CUL4A COPS3 LRR1 COPS6 CCNF COPS5 COPS8 FBXO7 FBXO9 WSB1 FBXO2 CDKN1A FBXL18 FBXL7 SQSTM1 FBXL8 FBXL4 DTL LRRC41 UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 HIF3A PSMD7 ELOB ELOC SOCS2 PSMD2 KLHL2 RBX1 SOCS6 KLHL3 PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL KLHL9 SPSB2 SPSB1 DCAF8 KBTBD6 DCAF5 KLHL5 DCAF4 PSMA5 DCAF6 PSMA6 WSB2 PSMA3 KBTBD7 OBSL1 PSMA4 KBTBD8 DCUN1D5 PSMA1 SPSB4 DCUN1D3 DCUN1D4 PSMA2 DCUN1D1 DCUN1D2 FBXO27 UBA52 COMMD8 PUM2 NPLOC4 PSMD12 DDA1 PSMD11 ANKRD9 FBXO21 UBXN7 PSMD14 COMMD2 FBXO22 COMMD1 PSMD13 COMMD6 COMMD7 PSMA7 COMMD4 FBXW12 COMMD5 PSMB6 SPSB3 FBXW8 PSMB7 CCDC8 CISH PSMB4 FBXO17 CUL9 DPP3 UFD1 PSMB5 FBXO15 UBD NAE1 DCAF7 UBB SOCS5 PSMB2 WDTC1 PSMB3 LMO7 CCDC22 FBXO10 COMMD10 UCHL3 FBXO11 UBC TULP4 FBXO4 PSMB1 KLHL41 DCAF16 KCTD7 DCAF17 FBXO6 DDB2 RPS27A FEM1C DCAF10 KLHL42 DCAF11 FEM1A FBXW4 CUL7 FEM1B FBXW5 CUL5 NEURL2 NEDD8 FBXW10 ADRM1 ERCC8 FBXW7 PSMC5 FBXW9 PSMC6 KLHL11 PSMC3 PSMC4 FBXW2 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 FBXL3 UBA3 FBXL5 MUL1 UBE2M GPS1 KBTBD13 CUL3 VCP COPS4 COPS2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 ASB16 FBXL20 ASB10 WDR5 SENP8 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 SKP2 RBBP5 ASB1 RBBP7 COP1 SOCS3 COMMD9 FBXO32 BIRC5 DCAF13 COMMD3 KCTD6 AMER1 UBE2D1 BRCA1 CAND1 NFE2L2 FBXW11 FBXL21P PALB2 SEM1 SKP1 CUL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC MMACHC RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle HNRNPC CCT6A CCT7 RBMX DBN1 HSP90AA1 CDC37 HSP90AB1 TWF1 CCT2 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B CUL3 PHIP TXNL1 SRRM1 TRA2B ACTG1 MYO6 STK38 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation TRAF2 RELA MAP3K7 NFKB1 TRAF6 UBA52 USP14 NFKB2 CHUK NOD1 NKIRAS1 NOD2 NKIRAS2 USP18 IKBKG UBB IKBIP RIPK2 IKBKB UBC RPS27A ALPK1 LRRC14 NLRX1 IRAK1 UBE2V1 NLRC5 NFKBIA AGER IRAK2 TIFA S100A12 TAB1 APP S100B SAA1 TAB3 TAB2 HMGB1 TP53 NFKBIB CASP8 UBE2N THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 TBXA2R GNG7 AAMP GNA11 GNGT1 GNG8 GNA13 GNGT2 GNG10 GNG12 GNG11 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes SRPRB ATP6V0D1 TPP1 CXXC1 PREB HDGF PPP2R5B KDELR3 ACADVL SHC1 ADD1 PDIA6 DNAJB11 DCTN1 SERP1 WFS1 SEC31A TLN1 DNAJC3 EXTL2 CUL7 FKBP14 GOSR2 MYDGF EXTL3 PLA2G4B HYOU1 EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 GSK3A EDEM1 WIPI1 YIF1A SYVN1 ARFGAP1 PDIA5 CTDSP2 SRPRA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 FGF18 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A TP53 ING2 PIP4K2B MAP2K6 PIP4P1 EP300 PIP4K2C ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B PPP2R1A TICAM1 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA PPP2CB TLR3 MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes CREBBP TALDO1 MAFG PGD NFE2L2 TKT EP300 G6PD CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL STAT3 GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 HDAC3 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 GBA1 ACTB CCNE1 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 GNG10 GNG12 GNG11 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells FGF10 ONECUT3 ONECUT1 PDX1 NKX6-1 PTF1A HNF1B RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G NFIX POLR3H SSB POLR2K NFIA POLR3K POLR2L NFIB NFIC POLR1C POLR1D ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription DHFR PCNA ORC1 TK1 CDT1 CDC6 HDAC1 CDK1 RRM2 E2F1 RBBP4 CDC45 FBXO5 TFDP1 TFDP2 LIN54 LIN37 CCNE1 LIN9 POLA1 TYMS LIN52 E2F4 E2F5 E2F6 CCNA1 RBL2 RBL1 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids CYP2F1 CYP4A22 CYP4B1 CYP2D6 CYP4F12 CYP4F22 CYP4F3 CYP4F8 CYP2A13 CYP2B6 CYP2J2 CYP4F2 CYP4A11 CYP2A7 CYP4F11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates MUS81 FIRRM BLM SLX4 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS HRAS SOS1 NTF4 NTRK2 BDNF NRAS DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency MCCC2 PC ACACA PCCA HLCS MCCC1 PCCB CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants ALK VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly CASP5 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO3 FMO1 FMO2 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation DRG2 RCCD1 ZC3H15 JMJD6 ASPH U2AF2 RIOX2 RPS6 F9 RPL8 RWDD1 JMJD4 KDM8 RPS23 JMJD7 RIOX1 ETF1 OGFOD1 RPL27A DRG1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR2 TGFB1 TGFBR1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP RBPJ MAML2 MAML1 KAT2B ONECUT3 KAT2A ONECUT1 HES1 SNW1 EP300 NEUROG3 HNF1B MAMLD1 MAML3 NOTCH1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 TACC3 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 CUL1 NOTCH4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN52 HDAC1 CDK1 E2F4 E2F5 E2F1 RBBP4 CCNA2 TFDP1 TFDP2 LIN54 LIN37 MYBL2 LIN9 RBL2 RBL1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2E1 CYP3A7 RXRA CYP51A1 CYP2F1 CYP4B1 CYP2W1 ARNT2 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP27A1 CYP39A1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR PTGIS CYP4F12 CYP3A5 CYP2A13 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP7A1 CYP1A1 CYP1B1 CYP2C19 CYP4F11 CYP11B1 TBXAS1 CYP2D6 FDXR POR CYP8B1 CYP2C18 CYP2B6 CYP46A1 CYP2S1 CYP4V2 FDX1 CYP3A4 CYP3A43 FDX2 CYP2A7 CYP2A6 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions CACNG2 CACNG3 CACNG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 STX1B CACNG8 DLG4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI PLA2G2D PLA2G2E MBOAT7 PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4C PLAAT3 PLA2G2A PLA2G1B PLBD1 PLA2G2F PLA2G4A DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus RB1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME3 ME2 VDAC1 WDR26 PDHB RMND5B PC LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 LDHC MPC1 PDK1 LDHB MPC2 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GLO1 GID4 GID8 UBC FAHD1 MPC1L RPS27A LDHAL6A LDHAL6B PDK4 GPT DLD SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT KIT DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 STRAP HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 TFAP2A HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A ARID1A FOXA2 TGIF2 EED RB1 RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX KLF4 H2AB1 SP1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis CYB5B SPTLC1 OSBP SPNS2 SPTLC2 SPTLC3 CSNK1G2 VAPA ABCG2 KDSR MFSD2B SPHK1 FA2H ORMDL2 ORMDL3 SPTSSB DEGS1 SPTSSA DEGS2 SPHK2 SAMD8 SGMS1 CERS3 ORMDL1 SGMS2 CERS4 ABCC1 CERS5 CERS6 CERS1 CERS2 PPM1L VAPB PRKD3 PRKD2 PRKD1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development HNF1A MAFA RFX6 INSM1 FOXA3 GCK ONECUT3 ONECUT1 HES1 PDX1 INS NKX6-1 PTF1A PAX6 SLC2A2 MAMLD1 RBPJ CREBBP MAML2 IAPP FGF10 MAML1 KAT2B KAT2A FOXO1 EP300 SNW1 AKT2 NEUROG3 HNF1B HNF4G MAML3 AKT1 FOXA2 NEUROD1 NOTCH1 NKX2-2 AKT3 PAX4 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PRKCA FES SOS1 STAT5A STAT5B PTPRU SH2B2 LYN CMA1 STAT3 PIK3R2 CBL FER PIK3R1 TEC GRAP NRAS GRAP2 JAK2 STAT1 SOCS1 CHEK1 MMP9 PTPN11 PTPN6 GRB10 YES1 RAC1 HRAS LCK FYN KIT SOCS6 SH2B3 GRB7 GAB2 PIK3R3 PIK3CA VAV1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 YWHAE YWHAQ YWHAG ZNF385A YWHAH BTRC UBE2V2 UBE2N HERC2 PLK3 CDKN1A CDKN2A CDC7 CDK2 CDC45 MDC1 PHF20 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 PSMD1 SFN YWHAZ PSMA5 PSMA6 PIAS4 PSMA3 PSMA4 BRCC3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 BABAM1 PSMB6 BABAM2 PSMB7 PSMB4 UIMC1 PSMB5 CSNK1E UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 CCNB2 CDC25A PKMYT1 WEE1 CLSPN MDM2 MDM4 NUP107 NUP160 RNF168 NUP85 NSD2 NUP43 RANBP2 SEC13 CDC25C NUP133 CDKN1B ABRAXAS1 TP53BP1 NUP37 ERCC6L ZWILCH BUB1B CCNE2 CDC20 NEK11 PPP1CC CCNE1 PPP2R1B H2AX PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 COP1 H2BC26 SGO2 H2BC12L DYNC1LI2 H2BC21 ZW10 MAD1L1 RNF8 CDCA8 PMF1 SKA1 CHEK2 SKA2 DSN1 H2BC17 H2BC12 H2BC13 H2BC14 RCC2 H2BC15 NDC80 ZWINT H2BC11 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 GSK3B CSNK1A1 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 GTSE1 RFC4 RMI1 PCBP4 RFC2 FBXW11 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 MCM7 MCM8 RPA3 SKP1 RAD17 RAD1 CCNA2 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 CLIP1 CUL1 ORC5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25C CDC25A CDC7 CDK2 CDC45 CHEK1 ATRIP CLSPN RFC5 RFC3 RFC4 RFC2 MCM10 RPA1 DBF4 HUS1 RPA2 MCM7 MCM8 RPA3 RAD17 RAD1 MCM3 MCM4 RAD9B MCM5 MCM6 ATR MCM2 RAD9A ORC5 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B SLC22A2 SLC22A1 MAOA PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination FZD5 FZD4 UBC FZD6 RPS27A USP8 FZD8 UBA52 RSPO3 WNT3A LRP5 RNF43 ZNRF3 RSPO2 RSPO1 LGR6 LRP6 LGR5 RSPO4 LGR4 UBB RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c ALG6 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest SFN PCNA CCNB1 EP300 PRMT1 CDC25C AURKA CDK1 E2F4 BAX TP53 CARM1 TFDP1 TFDP2 GADD45A RBL2 RBL1 ZNF385A OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism PM20D1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 MMR%REACTOME%R-HSA-5358508.3 MMR LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB NBEA CALM1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 KPNA5 ARIH1 KPNA3 PIN1 EIF2AK2 ISG15 MAPK3 STAT1 EIF4E IRF3 RIGI NUP205 POM121 NUP107 TRIM25 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 UBE2E1 NUP88 NUP43 RAE1 NEDD4 KPNA1 NDC1 RANBP2 SEC13 UBA52 PLCG1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 NUP35 NUP54 NUP37 JAK1 KPNB1 USP18 UBB EIF4E3 IFIT1 PPM1B EIF4E2 UBC FLNB MX2 RPS27A MX1 EIF4G3 EIF4G2 UBA7 EIF4A2 EIF4A1 KPNA2 EIF4G1 UBE2L6 EIF4A3 HERC5 UBE2N MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 HSPB1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 HSPA1A EIF4G1 PSMD2 PSMD3 PSMD1 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors LTB4R2 GPR17 CYSLTR1 CYSLTR2 LTB4R NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants ALK CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes CREBBP CITED2 BBC3 STK11 BCL6 FOXO1 EP300 NFYA NFYB NFYC BCL2L11 FASLG FOXO3 PINK1 FOXO4 DDIT3 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 TSPOAP1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus NEURL1B UBA52 DNER APH1A DLL4 MIB2 ITCH PSENEN DTX1 NCSTN MIB1 DTX2 APH1B NUMB PSEN2 DLK1 NEURL1 ADAM10 CNTN1 PSEN1 UBB UBC RPS27A DTX4 JAG2 JAG1 ADAM17 DLL1 ARRB1 ARRB2 NOTCH1 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis NKX2-5 LEF1 ISL1 CTNNB1 SRF KAT5 FOXO4 SMAD1 SMAD4 HEY1 MEF2C KAT2A HAND2 MESP1 HEY2 GATA6 TBXT TBX20 SMYD1 TBX1 EOMES MYOCD HAND1 LDB1 TBX5 WDR5 GATA4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 SERPINB13 CTSV SOCS3 CTSL CTSK CBFB SOCS4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 APOB S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 GSDMD BIRC3 GSDME USP14 BTRC TLR7 RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 HSP90B1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 LGMN MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB UNC93B1 SIGIRR TLR3 IRAK3 MEF2C CTSS UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 CNPY3 SAA1 TAB3 TLR8 SKP1 TAB2 CTSB TP53 NFKBIB FOS CTSV ELK1 CTSL CTSK MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 ABCB6 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 EGF EGFR NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 TACC3 PSEN1 UBB UBC RPS27A YBX1 JAG2 JAG1 DLL1 NOTCH3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose PMM1 MPI HK1 GMPPB PMM2 GMPPA PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 RBBP4 HLA-DRB5 TRAV19 RBBP5 HLA-DRB4 RBBP7 HLA-DPB1 TRAV8-4 HLA-DRA CDK4 HLA-DRB3 CD4 HLA-DRB1 H2AX HLA-DQB2 H2AB1 HLA-DQB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PTPN11 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 CSK PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 PTPN6 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions CD47 SIRPB1 PTK2B SIRPA FYB1 SIRPG PTPN6 PTK2 SKAP2 TYROBP PTPN11 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFAM TFB2M NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 GNGT1 RHOA GNGT2 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PDPK1 GNG10 AKT1 GNG12 AKT3 GNG11 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ2 KCNJ4 KCNJ14 KCNJ12 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP TXNIP SIRT1 KAT2B SIRT3 FOXO3 FOXO1 EP300 TXN FOXO4 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PALS1 PATJ TJP1 CRB3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 LYN EPO EPOR IRS2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP1 HLA-H PIK3R4 HLA-B SEC13 HLA-C ATG14 HLA-F HLA-G HLA-E BECN1 HSPA5 SEC24D PDIA3 SEC24C TAP2 SAR1B SEC31A TAP1 TAPBP CANX CALR SEC23A B2M HLA-A SEC24B SEC24A ERAP2 PIK3C3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade FRAT2 APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 FRAT1 PPP2R1A PPP2R5E PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 PTK6 STAT3 SOCS3 STAP2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy CETN1 PARK7 UBC RNASE1 GFAP CFTR PLIN3 RPS27A HSP90AA1 HSPA8 UBA52 ARL13B HSP90AB1 HBB HDAC6 PCNT EEF1A1 PLIN2 LAMP2 IFT88 UBB SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome DDX5 ZCRB1 VHL RB1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System KCNJ8 AP2A1 KCNJ11 ABCC8 ABCC9 ADCY9 NTRK3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT RTN3 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 DBNL KCNK6 KCNK7 KCNK1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 GRM1 GRM5 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 FLOT1 FLOT2 ARHGEF9 EPB41L3 GJC1 GJA10 GJD2 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 KCNG1 KCNG2 BCHE KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 PRKCA KCNK17 KCNK18 KCNQ1 KCNQ2 KCNQ3 SNAP25 KCNQ4 RAB3A KCNQ5 SLC32A1 KCNV1 SYT1 SLC6A13 KCNV2 ABAT KCNN1 KCNN3 SLC6A1 KCNN4 CPLX1 RIMS1 KCNF1 KCNC1 ALDH5A1 KCNK9 DNAJC5 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 GIT1 KCNAB1 KCNAB2 KCNAB3 KCNA10 IL1RAPL1 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 HSPA8 KCNK2 VAMP2 KCNK3 HCN2 KCNK4 HCN1 SLITRK3 CAMKK1 CAMKK2 SLITRK5 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 SYT2 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 KCNN2 PTPRF SYN3 SYN2 HRAS SLC6A11 PDPK1 PTPRS ARL6IP5 HOMER3 CACNA2D1 CACNA2D3 EPB41 STXBP1 EPB41L5 NRAS EPB41L2 HOMER1 HOMER2 CHAT PPFIBP1 PPFIBP2 GRIP1 MAPK1 GNAT3 SLC6A4 PANX1 CHRNB2 PANX2 NSF SIPA1L1 CHRNB4 DLGAP1 CHRNB3 GABRG3 DLGAP3 DLGAP2 GRIP2 GABRG2 SLC18A3 DLGAP4 CHRNA1 BEGAIN CHRNA3 SLC17A7 CHRNA2 MAPK3 APBA3 CHRNA5 APBA2 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 SHARPIN GRIK4 LRRC4B GRIK1 SYT9 GRIK2 GRIA1 SYT7 GABRR3 LRRTM3 CAMK2B GABRR2 GRIA2 LRRTM4 GABRR1 LRRTM1 CAMK2D LRRTM2 NPTN SRC ACTN2 HTR3E IL1RAPL2 HTR3C SHANK3 CAMK2A HTR3D NRG1 SHANK2 GRIN2C HTR3A SHANK1 GRIN2B HTR3B NLGN3 PICK1 NRGN NLGN1 GRIN2D GNAI3 NLGN2 AKAP5 GRIN1 NRXN1 GNAI1 DLG1 NRXN3 GRIN2A NRXN2 NCALD GNAI2 DLG2 SLITRK2 CHRND DLG3 SLITRK1 LRRC7 GLRA1 SLITRK4 DLG4 CACNG8 SLITRK6 NEFL GLRA2 PDLIM5 CALM1 GLRA3 NLGN4Y CHRNG CAMK2G NLGN4X SYT10 CHRNE SYT12 CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling JUN NTRK3 NTF3 PDGFB IRAK1 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PDGFRA RAC1 KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 ESR2 HDAC2 SRC NR4A1 NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 GSK3B IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis IRF1 IRF2 CYCS CHMP3 CHMP6 CHMP7 BAK1 ELANE GZMB GSDMD GSDME BAX TP63 IL18 IL1A IL1B CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A HMGB1 TP53 CASP5 CASP1 CASP4 CASP3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein BID BAK1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 POLB LIG3 APEX1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine CTH FMO1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 TST ETHE1 SLC25A10 CDO1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 GCGR GNGT1 GCG GNGT2 GIP GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCYAP1 ADCYAP1R1 GNG10 GNG12 GNG11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TFAP2A CDKN1A TFAP2C MYC DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG3 PPARGC1A MAPK12 PRKAB2 PRKAA2 MAPK14 MAPK11 PRKAG1 PRKAB1 PRKAG2 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 FAM13B WIPF1 WIPF2 CYFIP2 WIPF3 ARHGAP44 PREX2 DOCK11 ARHGDIA NISCH RALBP1 ARHGAP45 SPATA13 ARHGEF25 CIT IQGAP1 PLD1 FGD5 IQGAP2 CHN2 IQGAP3 ARHGAP22 FARP2 ARHGAP20 SRGAP3 SRGAP1 ARHGAP29 ARHGAP27 ARHGAP24 PKN2 ARHGAP33 PKN1 ARHGAP31 FAM13A ARHGAP30 DOCK6 ARHGAP9 DOCK9 DOCK8 DOCK7 WASL ARHGAP4 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARHGAP10 CDC42EP4 TRIO RASGRF2 WAS PLEKHG6 PARD6A CHN1 PAK6 PREX1 SH3BP1 MCF2L PAK3 RAC1 WASF3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 SRGAP2 ARHGEF10 CDC42BPA DEF6 PLEKHG2 KTN1 ARHGEF15 DLC1 PIK3R3 ARHGEF19 PIK3CA DIAPH3 ARHGEF18 ITGB1 VAV1 VAV2 TIAM2 TIAM1 SOS1 ARHGEF4 ARHGEF7 PIK3R2 SOS2 PIK3R1 ARHGEF5 NGEF ARHGEF6 KALRN GNA13 ABR SYDE2 ECT2 ARHGEF39 MCF2 ARHGAP12 PLD2 CDC42 ARHGAP25 ARHGAP23 DOCK5 DOCK4 FMNL1 DOCK3 LAMTOR1 ALS2 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 ARHGAP42 BAIAP2L1 OPHN1 ARHGDIB EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PAK1 RACGAP1 NHS ABL2 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 GIT2 CAV1 MCAM SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 POU2F1 TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP MAPK1 CSTF3 CSTF2 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 SNRPB SRSF9 RBM8A CPSF4 CHTOP CPSF1 ALYREF CPSF3 CPSF2 YBX1 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants FLT3 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC YWHAE YWHAQ YWHAG YWHAH TRAF2 TNFSF10 UNC5A KPNA1 DAPK1 UNC5B DAPK2 DAPK3 FADD BIRC2 CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 E2F1 APPL1 DFFB DFFA DBNL ACIN1 TFDP1 KPNB1 TFDP2 GAS2 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 ARHGAP10 TICAM1 PKP1 LY96 AKT2 BMF BMX STK24 STK26 AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 PPP3R1 TP53BP2 DNM1L DSP OMA1 OCLN OPA1 DSG1 DSG3 TNFRSF10B TNFRSF10A PLEC STAT3 DYNLL1 UACA ADD1 BAK1 GZMB CDKN2A MAGED1 DYNLL2 MAPK1 PPP1R13B MAPK8 CTNNB1 BCL2L11 TJP1 FAS FASLG MAPK3 BAD PMAIP1 CDH1 YWHAB SATB1 PSMD8 PSMD6 PSMD7 PSMD2 CASP6 PSMD3 AKT1 PSMD1 PRKCD APC SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BAX PSMD13 TP63 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC BBC3 BCL2 DSG2 PSMB1 RPS27A BCL2L1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TP73 TP53 PAK2 PTK2 CASP9 CASP7 APAF1 DIABLO AKT3 CASP3 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 CYP2U1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CD36 ITGB5 CYBB CYBA ITGAV INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF28P SCOC SYS1 KDELR1 GOLIM4 KDELR3 GCC2 GCC1 RAB43 RAB41 GOLGA5 KIF5C GOLGA1 ARFIP2 KIF21A KIF21B RHOBTB3 KIFAP3 KLC1 COG8 KLC4 COG7 KLC3 COG6 KLC2 COG5 COG4 COG3 COG2 COG1 RINT1 RAB30 RAB36 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 ARL1 KIF3B SEC22B MAN2A2 VTI1A KIF3C RAB9A RAB6B RAB9B KIF5B RAB39A KIF5A KIF18B KIF4B ALPP KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 M6PR MAN1A2 KIF13B TMED3 VPS45 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 KIF6 BET1L STX5 KIF27 COPZ1 RAB33B KIF9 KIFC2 KIFC1 NAA35 NAA38 VAMP4 PAFAH1B3 ARF5 NAPA GBF1 TGOLN2 NAPB NBAS TMF1 RAB6A STX16 RAB1A STX18 RAB1B GOSR1 NAPG STX10 CYTH3 ARFRP1 CYTH2 GALNT1 CYTH4 CUX1 VPS51 VPS53 VPS52 MAN1C1 SNAP29 BNIP1 ARFGAP3 STX6 ARFGAP2 VPS54 DYNC1LI1 CAPZB CYTH1 RIC1 DYNC1LI2 GALNT2 ARCN1 ZW10 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF MAN2A1 KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 PLIN3 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 IGF2R ACTR1A ARF1 GOLGA4 VAMP3 DCTN2 CAPZA1 DCTN3 GOSR2 RACGAP1 YKT6 ARFGAP1 USP6NL HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 HS6ST1 HS6ST2 HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function JUP PRDM8 CTNND1 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism CSPG4 GUSB ARSB CHST3 CHST14 DSEL DSE UST CHST15 IDUA CHPF NCAN HEXB CHSY1 HEXA CHST11 CHST12 BGN GLB1L3 CHSY3 CHST13 DCN GLB1L2 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b MPI NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors LPAR4 ADORA2B GPR17 P2RY10 P2RY11 LPAR6 ADORA2A P2RY12 P2RY6 P2RY13 P2RY2 P2RY14 P2RY1 P2RY4 ADORA3 ADORA1 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy MAP1LC3A FUNDC1 VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 ULK1 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN CSNK2A1 TOMM40 CSNK2A2 UBE2D2 UBE2D3 CSNK2B MTERF3 PINK1 UBE2N NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes CREBBP GEM ARNT NAMPT CDK5 RBFOX3 INS PLK2 NPAS4 MDM2 IQSEC3 MAPK1 ARNT2 BDNF XPO1 FOS BMAL1 CDK5R1 MAPK3 RET SYT10 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling JAK3 STAT5A STAT5B STAT3 IL9 JAK1 STAT1 IL2RG IL9R SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNA13 GNGT2 GNAT3 PLA2G4A GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 TBXA2R GNG7 AAMP MAPK14 GNA11 GNG8 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 P2RY1 GNG12 GNG11 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 GPRIN1 GRIA2 HDAC1 HDAC2 OPRK1 GRIN2B SIN3A SLC2A3 MET GRIN2A TRPC3 OPRM1 PTPN1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin PIK3CB RAPGEF1 SOS1 STAT5A STAT5B SHC1 PIK3CD LYN PIK3R1 PIK3CG PIK3R5 NRAS PLCG1 HRAS JAK2 GAB1 PLCG2 CRKL PIK3CA EPO VAV1 EPOR IRS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis UBC ENO1 TRIM27 RPS27A RAB7A KPNA1 SFPQ UBA52 ATP6V1H MAPK1 NOS2 CTSG VPS33B DUSP16 CORO1A PGK1 HGS RNF213 RAB5A GSK3A KPNB1 MAPK3 UBB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ACADL HADHA ACADM DECR1 ECI1 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNG13 ARHGEF9 GNB2 GNB1 ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 GNAT3 GABRG3 GABRG2 GABRB3 GABRB2 GABRB1 GNG3 GNG2 GABRR3 GNG5 GABRR2 GNG4 GABRR1 GNG7 NPTN GNG8 GNAI3 GNAI1 GNAI2 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u DPM3 DPM1 DPM2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IQGAP1 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 ADCY8 GNGT1 KCNC2 ADCY6 GCG ADCY5 GNGT2 RAP1A PRKACG PRKACA PRKACB GLP1R RAPGEF3 RAPGEF4 KCNB1 GNG3 ITPR1 KCNS3 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A KCNG2 AKAP5 GNG10 GNG12 GNG11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRA2C ADRA2B ADRB1 ADRA2A ADRA1D ADRB2 ADRB3 ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CREBBP MAFK NFE2L2 EP300 CCL2 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME UGT2B7 ABCB1 UGT1A3 AKR1C1 CYP3A4 HSD11B1 HSD11B2 ALB UGT2B17 SERPINA6 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC TAB3 RPS27A TICAM1 TLR3 TAB2 MAP3K7 TRAF6 UBA52 UBB TAB1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex NEDD4L ITGB8 ITGB5 SERPINE1 PMEPA1 FURIN PARP1 BAMBI STRAP HDAC1 RHOA TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 MAPK1 ITGA8 SKIL PPP1R15A MAPK3 TGFB2 ATP1B4 TGFB3 SKI CDK8 NCOR2 SMAD2 MTMR4 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC SMURF1 TGFBR3 E2F4 FKBP1A CCNT2 PPM1A E2F5 UBE2D3 XPO1 RBL1 TGIF1 STUB1 UBE2D1 TGIF2 TRIM33 CCNK CBL CCNC UBA52 CDKN2B COL1A2 PPP1CA USP15 CCNT1 TFDP1 TFDP2 PPP1CB PPP1CC UBB UBC SP1 UCHL5 RPS27A CDK9 EP300 JUNB PARD6A NEDD8 CGN F11R RNF111 MEN1 PRKCZ WWTR1 PARD3 USP9X LTBP4 ITGB3 ARHGEF18 ITGB1 LTBP3 ITGAV LTBP1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 C4A C3 CFB C4B_2 C2 C5 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 LTC4S PON3 ALOX5AP PON2 PON1 GPX2 GPX1 ALOX5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins FZD2 FZD5 FZD7 WNT5A FZD4 PRICKLE1 FZD1 FZD8 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 SCRIB VANGL2 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PARD6A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 DVL2 PSMC1 PSMC2 FZD3 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance CLTB ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 TYROBP DOCK1 ERBB2 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM ANK1 SEM1 FYN CLTC CLTA AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 MSI1 COL6A2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 ROCK1 ROCK2 CNTN1 DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 YES1 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PDGFB CTSG PRSS2 KLK2 A2M PECAM1 P4HB TIMP1 BMP2 PLG LAMA5 LAMA2 PPIB LAMB3 LAMC3 LAMB2 LAMA1 P4HA1 LAMA4 ELANE P4HA2 LAMA3 FN1 P4HA3 LAMB1 LAMC2 LAMC1 VTN CAPNS1 CAPNS2 CAPN2 CAPN1 BMP7 CAST DAG1 MMP1 MMP2 MMP3 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 FBLN1 LTBP3 FBLN2 LTBP1 FBLN5 LOXL1 LOXL2 COL17A1 EFEMP2 COL15A1 COL16A1 EFEMP1 COL13A1 ITGB8 GDF5 COL14A1 COL11A1 PLEC MFAP5 COL11A2 BMP4 COL12A1 MFAP4 COL19A1 LOX COL10A1 MFAP3 COL28A1 MFAP2 FBN1 COL26A1 COL27A1 COL24A1 COL25A1 ACTN1 NCSTN COL22A1 COL23A1 COL2A1 ADAM10 COL5A1 PSEN1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 SDC4 COL5A2 COL8A2 SDC2 COL20A1 SDC3 COL4A6 COL6A3 COL21A1 COL8A1 COL4A5 COL6A6 COL6A5 NTN4 CDH1 CTSS SDC1 PRKCA KLKB1 COL1A1 COL1A2 ITGA10 PRSS1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 PHYKPL CTRB2 CTRB1 P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 DTNA DTNB SSPN CTSB DDR1 MMP20 MMP24 TPSAB1 MMP13 MMP10 MMP12 MMP11 MMP14 MMP16 CASP3 MMP15 COL18A1 MMP17 MMP19 ITGA3 DDR2 ITGB4 TMPRSS6 ITGA1 DRP2 NID1 DMD NID2 JAM2 ITGA6 FURIN JAM3 PLOD3 PLOD2 PLOD1 SPP1 CAPN8 CAPN9 CAPN6 TGFB1 CAPN7 CAPN5 CAPN3 PCOLCE ADAM15 ADAM12 ADAM9 UTRN CD151 HTRA1 SCUBE3 SNTG2 SCUBE1 CRTAP VCAM1 TRAPPC4 BMP1 ITGA11 COLGALT2 MMP25 ITGAE TIMP2 SGCE SGCD SGCA SGCB ITGB7 COLGALT1 SGCG ADAM17 SNTA1 ITGAD PCOLCE2 SPOCK3 SGCZ CAPN13 NCAN CAPN14 CAPN11 CAPN12 BGN CAPN10 TLL2 DCN TLL1 SNTB1 BCAN CASK SNTB2 VCAN CMA1 ADAM8 ITGAM SH3PXD2A ITGB2 FGF2 TTR F11R CTSD ITGB3 ITGA2B ITGB1 COL3A1 ITGAV COL4A2 NCAM1 COL4A1 ITGA5 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 ITGAL TNXB LRP4 ACAN TGFB2 CEACAM6 LUM CEACAM8 TGFB3 CD47 DSPP COL9A1 CD44 ITGA4 COL9A3 COL9A2 AGRN FMOD ADAMTS4 ADAMTS5 NRXN1 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 KDR ADAMTS9 THBS1 ADAMTS16 ADAMTS14 ADAM19 FGB ADAMTS18 FGA MMP8 FGG MMP9 PDGFA CEACAM1 PXDN BSG CTSV CTSL MMP7 CTSK TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling XIAP TRAF2 FADD USP4 BIRC2 USP2 BIRC3 MIB2 CYLD RBCK1 OTUD7B RIPK1 USP21 SHARPIN TNF TBK1 OPTN TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 NEK2 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 COPS5 PSMD3 PSMD1 GSK3B CUL1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT2 GPAM PLA2G4A PLA2G2A RAB5A PIP4K2A PIP4K2B LIPI PIP4K2C LIPH BMX STARD7 RUFY1 PLBD1 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 PTPMT1 PIP5K1A PIP5K1B CHKB CHKA STARD10 ARF3 ACHE MTMR14 LPCAT1 OSBPL10 GNPAT PIP4P1 GPAT4 GPAT3 CEPT1 BCHE AGK LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 LCLAT1 PIP5K1C PCYT2 PGP PLA2R1 INPP5D ABHD4 PIK3CG PIK3R6 ABHD3 PIK3R5 ARF1 OSBPL8 RAB4A OSBPL5 OCRL SYNJ2 SYNJ1 PIK3CD PIK3C2G PIK3C2B ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B TPTE AWAT2 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 RAB14 LPGAT1 PITPNB CPNE7 CPNE6 GDE1 CPNE1 CPNE3 MFSD2A SACM1L PISD PLA1A PGS1 PTDSS2 PTDSS1 INPP5J INPP5K TMEM86B PTEN MTMR1 PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 GDPD1 GDPD3 GDPD5 PIK3CB PNPLA7 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 ETNPPL PLEKHA8 PNPLA3 PNPLA6 PTPN13 INPPL1 PLB1 ENPP6 PIK3R3 SBF1 PIK3CA SBF2 TPTE2 PIK3C3 MIGA2 MIGA1 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 INPP5E CHAT PLD4 PLD6 PLD3 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 PI4KA VAC14 PI4K2B PLD2 MTMR10 ALPI MTMR2 GPD2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A PCTP LPIN1 FIG4 LPIN2 INPP4B MGLL PLA2G4F PIKFYVE LPIN3 INPP5F PI4K2A PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 AGPAT5 PLA2G1B AGPAT1 SELENOI AGPAT3 AGPAT4 PLA2G2F PLA2G2D PLA2G2E CHPT1 GPD1L CDS1 PITPNM1 PITPNM3 PNPLA2 PITPNM2 CDIPT SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC MRE11 NLRC3 IFI16 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions ITGA10 CHL1 ITGA2 ITGA1 ANK1 CNTN6 HSPA8 NRP1 ITGB1 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKAR2A PRKACG PPP3CB AKAP5 PRKACA PRKACB OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF QRFPR HCRTR1 QRFP NPFFR2 HCRT NPFFR1 HCRTR2 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis RXRA NR1H2 NR1H3 RXRB NCOR2 NCOR1 UGT1A3 FABP6 NCOA1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks RAD50 MRE11 KPNA2 ATM KAT5 NBN MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR5AL1 OR8H3 OR8H2 OR8H1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 KCNMA1 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 SLC17A8 OR2A25 OR51I2 ITPR3 TAS2R30 TAS2R31 LRP8 OR10S1 TAS2R38 KCNMB1 OR52K2 OR51I1 TAS2R39 OR52K1 CNGA2 APOB RPE65 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 ATP2B1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 TAS2R50 OR4D1 OR5F1 OR10Z1 NMT1 OR52R1 OR4C6 OR4C5 OR3A3 SPTAN1 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 HSD17B6 OR4C45 OR5AN1 OR4B1 OR4C46 GSN OR8J3 OR6F1 OR8J2 FNTA OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 PRKCQ OR5H14 OR2D3 OR52A4P CYP4V2 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 CALHM1 OR6K2 CALHM3 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 CAPZA2 OR5H6 OR4F5 OR2B3 SDC4 OR4F4 OR2B2 SDC2 OR10K2 SDC3 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 GPC1 OR51A7 OR2A2 GPC3 TAS2R7 GPC2 OR52J3 GPC5 RTP2 GPC4 OR51H1 TAS2R8 GPC6 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 SDC1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 OR51G2 OR51G1 OR52I2 SNAP25 OR52I1 RAB3A OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 DNAJC5 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 MSN OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 CAPZA1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LRP2 AWAT2 GNG13 GNB1 GNB3 GNGT1 RDH5 RLBP1 HSD17B1 CAPZB AKR1C1 TTR AKR1C4 PLB1 SPTBN1 CALM1 RDH11 RDH10 RDH16 AKR1C3 DHRS3 DHRS9 APOA2 APOA1 APOA4 LPL LDLR GPIHBP1 APOC3 TRPM5 TRPM4 MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 GRM1 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B PLCB2 MYO3A FSCN2 EZR TWF2 PCDH15 PDE6B CABP2 PDE6A USH1C CACNA1D CABP1 LRRC52 ESPNL PDE6G EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 LHX2 STX1A SCN1B OTOF SCN3A SCN2A SCN2B PRKCA KCNQ4 SCN9A SCN4B VAMP2 ABCA4 SCNN1G SCNN1D SCNN1B SCNN1A RBP4 RDH12 OPN1LW RBP1 LRAT STRA6 OPN1MW CASK OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 GUCY2D OR2AE1 GUCA1B OR11H6 GUCA1A OR11H7 GUCA1C OR2L8 GUCY2F OR1J4 GRK1 OR2L5 GRK7 OR11G2 FNTB OR1J2 RHO OR2L3 CNGA1 GNAT1 OR4P4 OR1J1 RCVRN OR2L2 CAMKMT OR10AD1 RGS9BP OR6T1 SAG OR4K15 NMT2 RBP3 PPEF1 OR4K14 METAP1 OR4K13 METAP2 OR13J1 CNGB1 OR7A2P CHRNA9 OR2K2 CHRNA10 OR1I1 KCNN2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 GNAT3 OR1L1 OR5T3 HSPG2 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOE OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P EPB41L1 OR5AS1 OR2T8 OR2T7 OR2T6 AGRN OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 APOC2 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 KCNJ2 OPN1SW OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 LRP1 RETSAT OR6C74 OR14I1 APOM OR10A7 OR56A5 BCO2 OR7A5 BCO1 OR10A2 OR56A4 AKR1B10 CLPS OR10A4 RBP2 OR56A3 SLC24A1 OR10A3 LRP10 OR10A6 LRP12 OR56A1 PNLIP OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL SRC YWHAB HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex XIAP SOX17 APC SRY YWHAZ SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 TCF7L2 PYGO1 BCL9 TCF7L1 PYGO2 HDAC1 UBA52 LEF1 TCF7 TLE4 TLE2 TLE1 BTRC RBBP5 CTNNB1 CTBP1 UBB UBC ASH2L RPS27A KMT2B SOX2 AKT2 MEN1 SOX9 TLE3 XPO1 DPY30 WDR5 AKT1 CHD8 CBY1 SOX3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CDK1 CCNB2 CLIP1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN JMJD6 RIOX2 BGLAP EIF5A DHPS FN3KRP EIF5A2 FN3K ICMT DOHH RPL8 STS RWDD1 JMJD4 KDM8 JMJD7 ARSA ETF1 RIOX1 OGFOD1 SUMF2 SUMF1 DRG1 DRG2 RCCD1 ZC3H15 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD F8 RPL27A ARSB ASPH U2AF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 RPS6 DPH6 DPH7 EEF2 F7 F9 PROC F10 TPST2 GGCX PROS1 TPST1 PROZ F2 GAS6 RPS23 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 CD209 BTN3A2 BTNL2 PPL XDH INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals MT1G MT1H MT1X MT4 MT1B MT3 MT1E MT2A MT1A MT1M MT1F GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib SLC37A4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib ERBIN HSP90AA1 ERBB2 CDC37 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 RASGRP2 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A RARRES2 IGF2 RAF1 RAB27B IGF1 PPBP RAPGEF3 CYRIB MANF RAPGEF4 SELP TF SCCPDH CALU MAGED2 PLA2G4A HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 ITPR1 CTSW ITPR2 ORM2 ITPR3 SERPINA4 TMSB4X PSAP ALB PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 TRPC7 ABCC4 AHSG ANXA5 F5 TRPC6 PLCG2 F8 TRPC3 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 CRK LEFTY2 LY6G6F LHFPL2 PCYOX1L CD9 FLNA FN1 F2RL2 F2RL3 LCP2 F2R LAT PRKCB RAC1 VAV3 PRKCQ P2RY12 P2RY1 VAV1 VAV2 MPL THPO ACTN1 GNA13 ADRA2C ADRA2B ADRA2A TBXA2R AKT1 GP1BB PRKCD PRKCA GP5 YWHAZ GP9 LYN PIK3CG PIK3R6 PIK3R5 GP6 CFL1 PF4 SOD1 AAMP MAPK14 PPIA TUBA4A PRKCG PRKCE GNG10 GNG12 GNG11 GNG13 GNB2 CFD GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TGFB1 GNGT2 GNA14 GNG3 GNA15 PDPN MPIG6B GNG2 CLEC1B GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 EGF PIK3CB PFN1 PRKCZ BCAR1 PCDH7 PDPK1 PIK3R3 PIK3CA ITGB3 ITGA2B SOS1 BRPF3 SPARC RAC2 SHC1 SERPINE1 RHOG PIK3R2 PIK3R1 GP1BA RHOA RHOB MAPK1 GNAT3 FCER1G MAPK3 PTPN1 TGFB2 PTPN11 TGFB3 CDC42 MGLL DGKG SRC ACTN2 DGKE DAGLA DGKD DGKB DGKA ABHD6 GNAI3 ABHD12 PRKCH GNAI1 DGKZ DGKQ GNAI2 DAGLB DGKK DGKI DGKH CALM1 CD36 VEGFB VEGFC VEGFD THBS1 VEGFA ALDOA GNA12 CSK FGB FGA VWF FGG APBB1IP TLN1 VCL PTPN6 SYK LCK FYN APP F13A1 POTEKP ISLR LAMP2 HABP4 PROS1 FAM3C CHID1 F2 PTK2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 TREX1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction KCNJ11 ABCC9 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 GUCY1A2 GUCY1A1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MME ATP2B4 NPR1 ATP2B3 NPR2 ATP2B2 NPPC ATP2B1 CORIN TRPC1 CES1 SLC8A3 TTN ANXA1 PXN KCNK6 KCNK7 KCNK1 MYL12B CACNA2D2 MYL6 MYH11 CACNB2 NKX2-5 SCN11A SCN10A TMOD3 SCN1B SCN1A MYL9 KCNH2 SCN3B SCN3A KCNK10 GATA4 KCNK13 SCN2A KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 SCN9A KCNK9 SCN8A CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A ANXA2 KCNA5 SCN4A SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 TRIM72 PAK1 DYSF LMOD1 AHCYL1 MYL6B CACNA1H MYL12A MYLK CACNA1G CACNA1I ALDH2 PAK2 CALD1 ANXA6 MYL10 CAV3 TPM2 MYL11 TPM1 SORBS1 SORBS3 MYL5 MYL7 ITGA1 DMD SLN ATP1B3 ATP1B2 ATP1B1 PDE5A VIM ACTN3 KCNK12 KCNK15 FXYD4 MYL4 FXYD3 MYL1 MYL2 FXYD2 MYL3 DMPK FXYD1 MYBPC3 FXYD7 MYBPC1 FXYD6 MYBPC2 TNNC1 RYR1 TNNC2 RYR2 TNNT1 RYR3 TNNT2 TNNT3 TCAP CLIC2 TMOD1 TMOD4 TMOD2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 MYH3 MYH8 MYH6 ATP1A4 CACNG6 ATP1A3 CACNG7 TNNI1 ATP1A2 TNNI2 TNNI3 ATP1A1 KCNIP1 TPM4 KCNIP2 KCNIP4 TPM3 DES RANGRF PLN KCNIP3 FKBP1B ITGB5 CACNB1 CAMK2B CAMK2D ACTN2 CAMK2A TBX5 CACNG8 CALM1 CAMK2G CACNG4 KCNJ2 KCNJ4 KCNJ12 TLN1 VCL WWTR1 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A TCEA1 ERCC8 DDB1 XPA COPS7B COPS7A CUL4A COPS3 PPIE COPS6 COPS5 COPS8 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication ORC4 ORC6 H2BC9 ORC1 H2AZ2 ORC3 H4C9 ORC2 H2BC8 H2BC5 H2BC3 KPNA1 H2BC1 H2AC20 KPNB1 H2AX H2AB1 H2AC19 KPNA6 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ORC5 H3C15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT SOX17 XIAP SRY RNF146 SOX6 WNT5A SOX7 SOX4 WNT1 BCL9L RUVBL1 CTNNBIP1 FZD1 SOX13 RYK USP8 PYGO1 FZD8 BCL9 PYGO2 TLE4 TLE2 TLE1 CUL3 TNKS SMURF2 USP34 DPY30 WDR5 AXIN2 BTRC RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 KLHL12 LGR6 WNT3 LGR5 CCDC88C RSPO4 DACT1 LGR4 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 EP300 SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 PPP2R5E H3C15 FRAT2 FZD2 FZD5 H2BC9 FZD4 H2AZ2 H4C9 FZD6 PPP2R5B H2BC8 PPP2R5A H2BC5 PPP2R5D H2BC3 PPP2R5C H3-4 TCF7L2 H2BC1 TCF7L1 HDAC1 H2AC20 LEF1 TCF7 PIP5K1B CTNNB1 PPP2CA PPP2CB ASH2L MYC RSPO3 TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 APC YWHAZ PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 CSNK1G2 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 LEO1 WNT3A LRP5 PSMA7 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 KAT5 LRP6 PSMB4 DKK4 SFRP1 CTBP1 PSMB5 CSNK1E SFRP2 UBB WIF1 SOST PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A TERT ADRM1 MEN1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 WNT4 SMARCA4 PSMC1 CSNK2B PSMC2 TLE3 CHD8 CAV1 CBY1 SOX3 TRANSLATION%REACTOME%R-HSA-72766.7 Translation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 APEH HEMK2 MRPS18B MRPS18A ETF1 GSPT2 MRPS21 GSPT1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 TUFM MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 RARS1 EIF2B5 MRPL30 EIF2B4 EIF2B3 MTRES1 LARS1 EIF2B2 MTRFR NDUFAB1 EIF2B1 AIMP1 AIMP2 RPS4Y2 QARS1 RPS27L RPS4Y1 RPS4X MARS1 RPS15 RPS14 DARS1 RPS17 SARS1 EEF1E1 RPS15A RPS16 RPS19 KARS1 RPS18 RPS3 IARS1 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPN2 ASCC2 RPN1 ASCC3 EIF2S2 EIF2S1 DDOST MT-CO1 EIF2S3 EPRS1 EIF4EBP1 EIF4E EIF4B TRMT112 EIF1AX UBE2D2 EIF4H PSMD8 UBE2D3 EIF3M PSMD6 EIF3K MT-CO2 EIF3L PSMD7 MT-CO3 ELOB EIF3I ELOC EIF3J PSMD2 RBX1 EIF3G EIF3H PSMD3 EIF3E CUL2 EIF3F PSMD1 EIF3C EIF3D EIF3A EIF3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 LTN1 NPLOC4 PSMD12 SEC61G PSMD11 RPLP0 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SSR1 PSMC2 EIF4G1 SRPRA SRPRB MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 SEC61A2 SPCS3 SEC61A1 SPCS2 VCP SPCS1 SEC11A SEC11C MT-ATP6 MT-ATP8 MT-ND4L PARS2 EARS2 LARS2 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 EIF4A2 TCF25 SRP54 EIF4A1 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 MT-CYB SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 CARS2 VARS2 ANKZF1 KLHDC10 TSFM RPL4 EIF5B RPL5 MARS2 RPL30 DARS2 RPL3 EEF1G RPL32 SARS2 RPL31 NEMF RPLP1 EEF1D RPL34 MTRF1L RPL10L EEF1A1P5 RPL8 MTIF2 RPL10A MTIF3 RPL6 IARS2 RPL7 WARS1 RPL7A WARS2 RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 SRP14 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBE2D1 SEM1 EEF2 MRPS17 MRPS15 MRPS16 MRPS14 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2B GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 GRIA3 CAMK2G GRIA4 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO2 SLIT1 NCK2 ROBO1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism PLCB4 MTMR9 INPP5D MTMR7 PLCG1 PLD4 IPPK ISYNA1 IPMK OCRL INPP1 IP6K1 NUDT3 IP6K2 NUDT4 INPP5B SYNJ1 NUDT11 NUDT10 INPP5A IMPA1 PPIP5K1 PLCZ1 IMPA2 INPP4A PPIP5K2 INPP5J PLCE1 INPP4B IP6K3 MIOX ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers JUN SEL1L FZD8 ERLIN2 NPM1 KLC1 MAMLD1 IHH DERL2 TRAK1 ERLEC1 OS9 KIF5B PRR5 GSK3A EML4 KRAS MAML2 MAML1 FGFR2 JUNB RAC1 MAML3 VAV1 MAPKAP1 DUSP6 DUSP7 GZMB DCTN1 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 MAPK8 BCL2L11 PAPSS1 BAD CD19 SQSTM1 AGK RBX1 POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F PIK3CG POLR2G POLR2H PIK3R6 POLR2I PIK3R5 POLR2J POLR2K POLR2L WDR48 GTF2F1 GTF2F2 IL10 PTPN12 MSN TYK2 KAT2B PIK3CD KAT2A ALK LMNA TP53 VCP TNKS FOXO4 FOXM1 CDK8 SMAD2 SMAD4 SMAD3 ESR1 JAG2 ADAM17 MDM2 ZMYM2 PTEN ARRB1 ARRB2 TPR HDAC5 RANBP2 FGFR3 HDAC8 HDAC9 HDAC6 HDAC7 TPM4 RNF43 TPM3 KLB FLT3 IRS1 PPP1CC PPP2R1B IRS2 PPP2R1A PIK3CB TNKS2 PPM1B FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 HDAC10 FGF9 HDAC11 AKT2 HRAS PDPK1 GAB1 FLT3LG TWIST1 FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 CARS1 PIK3R1 NRAS FGF20 PPFIBP1 MAPK1 EEF1G FGF23 CHUK FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 SNW1 CAMK2B ESR2 CAMK2D SRC NR4A1 CAMK2A NRG1 TFG MPRIP FGFR1OP2 ZAP70 SND1 ZC3HAV1 EIF2AK3 NOX4 CALM1 ATIC CAMK2G DUSP8 DUSP9 MRAS FAM114A2 KDR PORCN MCL1 CD86 QKI CD80 NF1 KIAA1549 ERBB2 DUSP10 CCNB1 HES1 ESRP1 TRAT1 BIRC6 RPS6KB2 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 PHB1 AGTRAP ARAF AP3B1 SHOC2 PEBP1 CSK AGGF1 JAK2 CPSF6 MARK3 TENT4A SPRED3 FGB BRAP SPRED2 SPRED1 FGA VWF MYO18A KSR1 LRRFIP1 KANK1 PPP1CB FGG RRBP1 BRAF ETV6 WDCP KSR2 GOLGA4 FAM131B BIN2 CNKSR2 STRN APBB1IP CNKSR1 NCBP1 TLN1 NCBP2 VCL FRS3 JAG1 LCK SEM1 IRF4 DLL1 FYN BCL2A1 SKP1 HGF CLIP1 CUL1 CLTC GCC2 NTRK3 NTF3 PDGFB NEURL1B HES5 MIB2 RAP1B MIB1 HEYL RAP1A NEURL1 RAF1 PRF1 ICOS STAT5A IL10RA ZC3HC1 FIP1L1 FN1 CUX1 TRIP11 RPS6 PDGFRA PRKAR1A MYH9 KIT NOTCH1 FZD5 FZD4 HBEGF FZD6 TCF7L2 CDKN1A HDAC1 CTNNB1 MET CEBPB RNF213 ATG7 SEC31A RBPJ TNRC6C MOV10 MLST8 AGO3 AGO4 MYC AGO1 AGO2 TSC2 PIM1 MTOR YWHAB FKBP1A PSMD8 PSMD6 PSMD7 PSMD2 AKT1S1 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 PSMB5 UBB BCR PSMB2 PSMB3 LMO7 UBC PSMB1 RPS27A AKAP9 HEY1 HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CASP9 ERBIN CEP43 KDM7A TGFB1 RICTOR TGFBR1 TGFBR2 STAT1 CD28 IQGAP1 HSP90AA1 EGF CBL EGFR CDC37 PLCG1 RB1 CDKN1B MAP3K11 DUSP16 FGFR1 CLCN6 FOXO6 FOXO1 EP300 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 ITGA2B NRG2 STAT3 HDAC3 TBL1X NCOR2 NCOR1 TBL1XR1 HDAC4 HDAC2 PIK3AP1 AMER1 GSK3B CSNK1A1 AXIN1 APC STAT5B CCNC GRB2 HHAT SHH DHH CTBP2 CTBP1 DNMT1 CREBBP AREG BCL2L1 PTPN6 MAPK9 YES1 NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 EREG SYVN1 BTC EPGN AKT3 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP PPHLN1 H2AC20 MPHOSPH8 H2AX ZCCHC8 EHMT2 EHMT1 H2AB1 TASOR MTREX H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B RBM7 H3C8 MORC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SETDB1 H3C15 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK10 MAPK8 FOS MAPK3 MAPK9 MAPK14 ATF2 MAPK11 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 ALOX5 LTA4H DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 NEIL1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 C2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress GNG13 ITGA5 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 PIK3R2 GNB3 ADCY4 NFKB1 ADCY3 GNB5 ADCY2 ADCY1 ABL1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB CHUK STAT1 PTPN1 IKBKB PPP2CA PECAM1 MLST8 GNG3 GNG2 GNG5 NFKBIA GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 IKBKE AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 IKBKG PPP2R1B ANXA2 PPP2R1A PIK3CB CALCRL ADM TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PTK2 PIK3CA P2RY2 ITGB3 ITGB1 MMP14 GNG12 ITGAV MAPKAP1 GNG11 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor F8 VWF MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2A POLR2B BCDIN3D POLR2C XPO5 POLR2D AGO3 PRKRA POLR2E DROSHA RAN DICER1 AGO4 POLR2F TARBP2 POLR2G POLR2H AGO1 POLR2I AGO2 POLR2J POLR2K POLR2L DGCR8 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly HSP90AA1 IPO5 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis RXRA CYCS SAMM50 HDAC3 MTX1 APOOL NR1D1 CHCHD3 DMAC2L TBL1X NCOA1 ESRRA PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 MT-ATP6 PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 MAPK12 HCFC1 CALM1 ATP5PF ATP5PD PPARGC1A ATP5PB NCOA2 PPARGC1B ATP5F1C NCOA6 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 NRF1 ATP5PO GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HSPA9 HELZ2 ATP5MC2 CREBBP CHD9 ATP5MC3 ALAS1 ATP5MK ATP5MJ MICOS13 MICOS10 CHCHD6 MTERF1 ATP5MG MAPK14 GABPA MED1 MAPK11 SIRT5 TGS1 ATP5MF PPRC1 MEF2D ATP5ME PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 ATP5F1A IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 MTX2 PPARA ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion PRKCA CHRM3 GNA14 GNAQ MARCKS GNA15 PLCB3 PLCB1 PLCB2 GNA11 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors MEF2C RBFOX1 PPARG RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 H2BC15 TP53 H2BC11 ATM UBE2N MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase SHQ1 ACD DKC1 TINF2 TERF1 RUVBL2 TERF2 RUVBL1 TERT NHP2 ANKRD28 POT1 NOP10 TERF2IP WRAP53 PPP6C PPP6R3 RTEL1 CDK2 CCNA2 CCNA1 PIF1 GAR1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RIPK1 CASP10 MAVS FADD RNF135 RIGI CHUK IFIH1 CASP8 TRIM25 TRIM4 IKBKG CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions CDH24 CTNNB1 CDH11 JUP CTNND1 CDH8 CTNNA1 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 FCN1 MASP1 FCN2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway TALDO1 PGD DERA TKT RPIA PRPS2 PRPS1 RPEL1 RPE SHPK PGLS PRPS1L1 RBKS G6PD PGM2 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 FLRT1 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 GIPC1 ANOS1 MAPK1 FLRT3 FGF23 FGF22 SPRED2 SPRED1 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FRS3 FGF3 RPS27A FGF4 FGF6 FGF9 TGFBR3 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 SEL1L PSMA3 CFTR PSMA4 PSMA1 PSMA2 ERLIN1 ERLIN2 UBA52 PSMD12 PSMD11 RNF185 PSMD14 PSMD13 PSMA7 PSMB6 VCP PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 DERL3 DERL1 UBC DERL2 PSMB1 RNF5 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein PRMT1 UBE2I SRPK1 SUMO1 PARP10 SRPK2 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 CSNK1A1 PARP14 PARP8 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB RIPK1 UBC TICAM2 UBE2D1 TICAM1 RPS27A UBE2V1 LY96 TRAF6 UBA52 BIRC2 CD14 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB TLR4 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON GRK2 IHH ARRB1 SHH DHH ARRB2 SMO KIF3A CSNK1A1 PTCH1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress COX5B COX5A RELA NUDT2 PRDX3 NOX5 NQO1 GSTA3 COX6C GSTA1 ERO1A SESN1 SRXN1 CHD6 GPX3 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB COX6A1 BLVRA CCL2 ABCF2 COX6A2 TXNRD2 SOD3 CCS G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM ALB P4HB AQP8 CAT BTRC SOD2 CARM1 ATOX1 FBXL17 BACH1 PRKCI SLC7A11 MED1 NOTCH1 PRDX2 PRDX1 PTK6 CDKN1A CDKN2A SIN3A PRKAA2 MT-CO1 SQSTM1 ATF4 TKT MYC PSMD8 KEAP1 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 PSMD2 RBX1 PSMD3 AKT1 PSMD1 IDH1 PRKCD NCF1 PSMA5 NCF2 PSMA6 NCF4 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 NPLOC4 PSMD12 PSMD11 UBXN7 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CYBB PSMB4 CYBA DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 TALDO1 UBC PSMB1 RPS27A SOD1 ADRM1 CSNK2A1 PSMC5 GPX1 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PPARA CYCS MAFG PGD MUL1 CUL3 VCP PRDX6 NLRP3 TRIM21 GSTP1 HBA2 SESN2 HMOX2 GPX2 MAP1LC3B EGF SMARCD3 SKP2 TXNRD1 EP300 AKT2 STAP2 COX7A2L TXN RXRA STAT3 NFKB1 ABCG2 HBB HDAC3 COX4I1 COX4I2 TBL1X NCOA1 FABP1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 ABCC3 ABCC1 HM13 EIF2AK3 AMER1 NOX4 GSK3B NCOA2 NCOA6 ME1 TXN2 BRCA1 HELZ2 CREBBP SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 PALB2 TGS1 SEM1 COX7B SKP1 COX7C COX8A COX8C CUL1 AKT3 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 BCL11B SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 PHF10 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 BICRAL BRD7 BICRA BRD9 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 DPF1 HDAC2 DPF2 KAT8 DPF3 KDM5B SUZ12 KAT14 SETDB1 SS18L1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SS18 SMARCB1 BCL11A AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 KDM6A DNMT3A PBRM1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 AP2M1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA CSTF2T CLP1 ZNF473 SNRPD3 FIP1L1 SNRPB PABPN1 CPSF4 SLBP CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 CSTF2 CPSF2 CSTF1 PAPOLA SYMPK LSM10 NCBP1 LSM11 NCBP2 PCF11 SNRPG WDR33 SNRPE SNRPF TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR GCHFR GCH1 SPR NOS3 PTS HSP90AA1 PRKG2 AKT1 CALM1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion FES PLXNA2 PLXNA3 HSP90AA1 HSP90AB1 PAK1 PAK3 LIMK1 RAC1 FYN CFL1 PLXNA4 PAK2 NRP1 PLXNA1 SEMA3A CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAH YWHAZ WEE1 SFN CCNB1 CDC25C CDK1 YWHAB CHEK2 YWHAE CCNA2 CCNA1 YWHAQ CHEK1 YWHAG TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN TIMP1 NCSTN APH1B PSEN2 TIMP2 PSEN1 TGFBR3 APH1A MMP14 MMP16 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP5 GP9 VWF GP1BA GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 FABP6 MGLL PLIN1 PPP1CA ABHD5 FABP12 PRKACG PRKACA LIPE PRKACB FABP9 PPP1CB FABP1 PPP1CC CAV1 FABP2 FABP3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling IL21R JAK3 STAT5A STAT5B STAT4 STAT3 JAK1 STAT1 IL2RG IL21 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine CBS CTH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly PET100 COX5B COX5A COA5 CMC1 SCO1 COX6C TACO1 SMIM20 COX4I1 COX4I2 SURF1 COX6A1 COX6A2 COX16 TIMM21 COX15 MT-CO1 COX18 COX6B2 HIGD1A COX6B1 COXFA4 COX7A2 COX7A1 COX11 COX19 COX17 COX14 RAB5IF COQ10B COQ10A TMEM177 COA3 SCO2 COA1 COX7A2L MT-CO2 COX7B MT-CO3 COX7C HIGD2A PET117 COX8A COX20 COX8C TMEM223 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM RTEL1 MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PIK3R1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 CD19 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CD22 TRPC1 IGKV2D-40 PIK3AP1 IGHV3-11 IGHV3-13 IGLV7-43 CALM1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 BTK IGLC3 BLNK IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 PIK3CD IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PTPN6 SYK AHCYL1 FYN VAV1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB P4HA1 P4HA2 P4HA3 COL1A1 COL1A2 ADAMTS14 P3H2 P3H1 P3H3 SERPINH1 COL3A1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC9 H2AZ2 H4C9 H2BC8 NCOA2 H2BC5 H2BC3 H2BC1 H2AC20 PKN1 KDM1A H2AX KLK3 KLK2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B KDM4C H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 AR KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling CASP10 FAS CASP8 FASLG FADD SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins DNMT1 BMI1 RING1 UBE2I SUMO1 RNF2 DNMT3B CBX8 PHC2 PHC1 DNMT3A CBX4 PCGF2 CBX2 PHC3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FRS2 KLB PTPN11 FGF16 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus CLP1 POP5 POP7 POP1 RPP30 POP4 RTCB CPSF4 TSEN2 TSEN54 CPSF1 RPP38 CSTF2 RPP21 RPP25 DDX1 C2orf49 RPP40 TSEN15 ZBTB8OS TSEN34 NUP205 POM121 RPP14 NUP107 NUP188 RTRAF AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 XPOT NUP88 FAM98B NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ELAC2 TRNT1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) UBC DERL2 SEL1L RNF5 RPS27A OS9 MAN1B1 UBA52 RNF185 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 EDEM2 AMFR SYVN1 RNF103 UBB TRIM13 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1 OXCT2 ACAT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis GPI ENO1 ENO2 ENO3 ENO4 G6PC1 TPI1 PGAM1 PC PGAM2 ALDOC ALDOB ALDOA GAPDH PCK2 PGK1 SLC37A1 PGK2 G6PC2 PCK1 G6PC3 FBP1 FBP2 SLC37A4 GAPDHS CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SESN1 SESN2 SEC13 RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X RPS15 SAMTOR RPS14 SEH1L RPS17 NPRL2 NPRL3 RPS15A RPS16 GCN1 TCIRG1 RPS19 WDR59 RPS18 EIF2AK4 FLCN RPS3 MIOS RPS2 RPS11 ITFG2 IMPACT RPS10 DEPDC5 RPS13 KPTN RPS12 WDR24 RPS9 SH3BP4 RPS7 FNIP1 ATP6V1E1 RPS8 FNIP2 RPS5 KICS2 ATP6V1E2 RPS6 CASTOR1 RPSA CASTOR2 ATP6V1G1 RPS3A RPS26 ATP6V0B ATP6V0E1 ATP6V1G2 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ATP6V1B2 TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A RPL4 RPL5 ATP6V1H RPL30 RPL3 RPL32 ATP6V0E2 RPL31 ATP6V1G3 RPLP1 RPL34 ATP6V1D RPL10L RPL8 ATP6V1C1 RPL10A ATP6V1F CEBPB RPL6 ATP6V1C2 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPTOR RPL37 ATF3 ATF4 RPL39 RPL21 MLST8 RPL23 SLC38A9 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 MTOR RPL10 RPL12 RRAGA RPL11 RRAGC RPL36A RPL14 RHEB RPL13 RRAGB RPL15 RRAGD RPL18 RPL17 RPL19 LAMTOR2 RPL39L LAMTOR1 RPL41 LAMTOR4 RPL35A LAMTOR3 RPL23A LAMTOR5 RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism CHST2 B4GALT4 CHST3 B3GNT3 GNS ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 GALNS FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 HEXB HEXA B4GALT2 GLB1L3 B4GALT3 PRELP GLB1L2 CHST6 OMD KERA GLB1L B3GNT7 GLB1 B3GNT4 OGN CHST1 B3GNT2 CHST5 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway XIAP RACK1 TRAF1 TRAF2 MAP3K7 USP4 BIRC2 USP2 BIRC3 CYLD RBCK1 OTUD7B CHUK IKBKG IKBKB RIPK1 USP21 SHARPIN TNF OPTN TAB1 TRADD TAB3 TNFAIP3 TAB2 RNF31 SPATA2 TNFRSF1A OTUD1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 TGFB1 CCL11 CCL2 STAT1 VCAM1 VIM CCL22 BCL6 IL6 TIMP1 RORC RORA NOS2 POU2F1 IL17F IL17A ANXA1 LBP LAMA5 HSP90AA1 FN1 S1PR1 JAK3 IL18 IL1A ITGAM IL1B ITGB2 LCN2 MMP1 MMP2 FGF2 TNFRSF1B FOXO1 IL6R JUNB SOCS3 SOX2 MAOA MMP3 TWIST1 HSP90B1 ITGB1 IL23R IL13RA2 IGHG4 IL13RA1 IGHG1 IL4R STAT3 IL23A FSCN1 PIK3R1 CDKN1A NDN LIF RHOU NANOG ALOX15 IGHE ITGAX OPRD1 OSM BATF CCND1 BIRC5 FASLG SOCS1 FCER2 MYC PTGS2 PIM1 ALOX5 HMOX1 AKT1 HIF1A OPRM1 CD36 MCL1 GATA3 VEGFA POMC COL1A2 IL4 JAK2 MUC1 IL12B IL12A IL13 JAK1 IL2RG IL10 MMP9 SOCS5 BCL2 TYK2 TNF BCL2L1 HSPA8 ICAM1 ZEB1 CEBPD IRF4 STAT6 F13A1 SAA1 TP53 FOS FOXO3 HGF SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN NTRK1 RIT1 NGF RIT2 BRAF VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis NUP85 TPR NUP62 POLR2A POLR2B NUP88 POLR2C NUP43 POLR2D RAE1 POLR2E POLR2F NDC1 POLR2G RANBP2 POLR2H SEC13 POLR2I NUP155 POLR2J NUP133 POLR2K NUP210 POLR2L NUP153 NUP93 NUP50 NUP35 NUP54 GTF2F1 GTF2F2 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids GGPS1 CYP51A1 SRD5A3 LSS SREBF2 SQLE MTF1 DHCR7 SLCO1B1 SLCO1B3 LDLRAP1 CUBN ACACB GPAM STS SLC51A SLC51B CYP27A1 SAR1B CYP39A1 PLPP6 LHB ABCB11 SEC23A MBTPS1 SCAP VDR ALB SLC10A1 MBTPS2 SLC10A2 STAR AKR1B15 SEC24B SEC24A AKR1B1 ARV1 CYP17A1 SMARCD3 STARD3NL SEC24D CYP7B1 SEC24C AKR1D1 CARM1 KPNB1 HSD17B7 CYP7A1 HSD17B1 HSD17B2 HSD17B3 HSD17B12 AKR1C1 NSDHL AKR1C2 ACACA FDXR MED1 AKR1C4 STARD3 STARD4 CYP8B1 STARD5 STARD6 MSMO1 CH25H CYP46A1 FDX1 ELOVL6 FDX2 RXRA SCD FASN CGA SLC27A2 HSD11B1 HSD11B2 IDI2 NFYA EBP NFYB CYP11A1 NFYC TBL1X LGMN NCOA1 ACOT8 CYP11B2 SERPINA6 CYP27B1 TSPO CYP24A1 CYP2R1 CYP21A2 TBL1XR1 FABP6 SUMO2 ABCC3 UBE2I GC NR1H4 HSD3B7 OSBP HSD3B2 PIAS4 HSD3B1 AMACR NCOA2 SLC27A5 NCOA6 RAN INSIG2 INSIG1 CYP19A1 POMC ACAT2 MVD OSBPL9 LBR OSBPL7 OSBPL6 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 BAAT HELZ2 ACOX2 CREBBP CYP11B1 SLCO1A2 SP1 CHD9 OSBPL1A TGS1 AKR1C3 HSD17B4 HSD17B14 IDI1 LRP2 MVK TM7SF2 HSD17B11 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 PPARA TSPOAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer APC FZD5 FZD4 PORCN FZD6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 FZD8 WNT3A LRP5 RNF43 KREMEN1 CTNNB1 KREMEN2 DKK1 TNKS DKK2 LRP6 CTBP2 DKK4 CTBP1 PPP2R1B PPP2R1A TNKS2 PPP2CA PPP2CB AMER1 GSK3B CSNK1A1 PPP2R5E AXIN1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation CYB5B HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NMT2 AKT1 ZDHHC21 CALM1 CAV1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation HBEGF SH3KBP1 EGF ARHGEF7 CBL EGFR UBA52 STAM STAM2 HGS PTPRK EPS15L1 PTPN12 EPN1 UBB SPRY1 PTPN3 CDC42 UBC RPS27A SH3GL3 AREG EPS15 SH3GL2 SH3GL1 SPRY2 TGFA EREG BTC EPGN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis MT-ND6 MT-ND4 NDUFC2 MT-ND5 NDUFC1 MT-ND2 MT-ND3 NDUFS8 MT-ND1 NDUFS7 NDUFS6 PYURF NDUFS5 NDUFS4 NDUFS2 TMEM126A NDUFS1 TMEM126B NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFAF8 FOXRED1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFA9 NDUFA8 NDUFAF2 NDUFA7 SFXN4 NDUFA6 NDUFAF3 NDUFAF1 NDUFA3 NDUFA2 NDUFA1 TMEM186 ACAD9 OXA1L DMAC1 DMAC2 NDUFS3 TIMMDC1 NUBPL LYRM2 HSCB NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 ECSIT NDUFB10 HSPA9 NDUFB11 NDUFV3 NDUFV2 NDUFB8 NDUFV1 COA1 NDUFA5 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling SLC25A14 UCP1 SLC25A4 PM20D1 UCP3 SLC25A27 UCP2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer SKP1 RBX1 NOTCH1 CUL1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TIAM1 ERBIN ARHGAP26 MPP7 VANGL1 RAC2 ARHGAP32 ABI2 TAOK3 PIK3R2 PIK3R1 ABI1 ESYT1 SAMM50 MTX1 ABR MCF2 PLD2 CDC42 DOCK4 ANKLE2 DOCK3 ARHGDIA LAMTOR1 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 IQGAP1 TFRC NCF2 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 EMD LBR GIT1 TMPO SWAP70 ARMCX3 CYBB CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 DSG2 VAMP3 RAB7A CDC42EP4 EPHA2 GARRE1 TRIO ARHGAP17 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 VAV3 NHS SLITRK5 DEF6 VAPB NCKAP1L PAK2 WASF2 PIK3CA PIK3R3 PAK4 DIAPH3 ITGB1 VAV1 GIT2 VAV2 CAV1 MCAM TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 INS PLK2 NPAS4 MAPK1 ARNT2 REST BMAL1 SRF NR3C1 MAPK3 CDK5R1 RET KCNIP3 CREBBP GEM ARNT TNRC6C MOV10 NAMPT CDK5 AGO3 AGO4 RBFOX3 AGO1 AGO2 MDM2 TNRC6A TNRC6B IQSEC3 BDNF XPO1 FOS SYT10 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B GALNT12 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 SULT1C4 SULT2A1 SULT1A3 TPST2 TPST1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression JUN ZNF217 EBAG9 KDM4B YY1 DDX5 GPAM CXCL12 ESR1 POU2F1 TBP HSP90AA1 CARM1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 H3-3B H3C8 MED1 H2AC8 H2AC6 CTSD H2AC7 H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 HSP90AB1 KDM1A CCND1 PTGES3 NRIP1 FKBP4 NCOA1 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 KANK1 CREBBP SP1 BCL2 CDK9 KAT2B FOXA1 TLE3 KPNA2 TGFA USF1 FOS GREB1 CHD1 PGR TFF3 TFF1 CXXC5 USF2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation BANF1 XRCC6 XRCC4 XRCC5 LIG4 PSIP1 HMGA1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PARS2 YARS2 KARS1 EARS2 LARS2 PPA2 NARS2 RARS2 TARS2 AARS2 CARS2 VARS2 HARS2 MARS2 DARS2 SARS2 FARS2 IARS2 QARS1 WARS2 GARS1 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 MET STAT3 HGF VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 STAT5A STAT5B BCL2L1 CDKN1A PIK3R1 GRB2 NRAS PIM1 HRAS GAB2 PIK3CA FLT3 NOX4 PTPN11 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion ALPI MGAM PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B SI AMY1C CLPS LCT GUCA2B CEL GUCA2A CHIT1 LIPF PNLIP PIR PNLIPRP3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production KIF28P IFNA2 IFNA8 MAFG IFNA13 IFNA14 IFNA16 IFNA17 KIF5C ABL1 MFN1 KIF21A MFN2 KIF21B KIFAP3 KLC1 KLC4 IFNA10 KLC3 KLC2 PRKACG IFNA21 PRKACA IFNB1 PRKACB KIF16B KIF3A KIF20B WEE1 KIF3B KIF3C KIF5B CDK5 KIF5A KIF18B KIF4B KIF4A KIF12 PHF21A KIF11 DOCK11 KIF15 KIF19 KIF13B VPS45 KIF1C KIF1B KIF1A KIF25 KIF22 RCOR1 KIF6 KIF27 SH2B2 KIF9 KIFC2 KIFC1 HMG20B DOCK6 DOCK9 CABLES1 DOCK8 DOCK7 RAB5A CAPZB MYB KIF26A KIF26B GATA6 H3-3B H3C8 PRKAR1B PRKAR2B KIF23 PRKAR1A RAC1 PRKAR2A ZFPM1 RBSN KIF20A KIF18A GATA2 H3C15 IRF1 IRF2 NFE2 HDAC1 HBB KDM1A KIF2A SIN3A CDK2 KIF2C KIF2B CAPZA2 CDC42 ITPK1 DOCK5 HDAC2 CENPE DOCK4 DOCK3 CBX5 SH2B3 GATA4 JMJD1C HBE1 GATA1 DOCK2 ZFPM2 DOCK1 GATA5 AK3 MICAL1 CARMIL1 HBG2 GATA3 HBG1 EHD1 EHD2 EHD3 MAFF HBD DOCK10 AKAP10 AKAP1 SH2B1 CABLES2 JAK2 MAFK CAPZA1 RAD51B RACGAP1 RAD51C TP53 IFNA5 IFNA4 IFNA7 IFNA6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism MAN2C1 MANBA MAN2B1 MAN2B2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease FGF18 SOS1 FGF1 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGFR3 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA FGF16 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis GP5 GP9 SERPING1 KLKB1 GP1BA ADAMTS13 F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 MAPK1 FST FOXH1 ACVR1B FSTL3 ACVR2B ACVR2A INHBB DRAP1 INHBA ACVR1C INHA MAPK3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs YAP1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ABL1 H2AC20 ITCH LMO1 LMO2 PSMD8 PSMD6 TCF3 PSMD7 TCF12 LDB1 PSMD2 PSMD3 PSMD1 GATA1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 GATA3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CDK7 PSMB4 MNAT1 PSMB5 H2AX UBB PSMB2 SPI1 PSMB3 H2AB1 UBC H2AC19 PSMB1 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 MYB H3-3B ADRM1 H3C8 H2AC8 H2AC6 PSMC5 H2AC7 PSMC6 H2BC17 SEM1 PSMC3 RUNX1 PSMC4 H2BC12 PSMC1 H2BC13 PSMC2 H2BC14 TP73 H2AJ H2BC15 TAL1 H2BC11 KMT2A CBFB GATA2 H3C15 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1D HTR1A HTR7 HTR1B HTR5A HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NTRK1 SOS1 MAPKAPK3 SHC1 NGF MAPKAPK2 NRAS MAPK14 MAPK11 RALA SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A13 SLC25A18 SLC17A8 SLC6A1 SLC6A5 SLC22A2 SLC22A1 SLC6A4 SLC6A7 SLC6A19 SLC6A2 SLC6A15 SLC6A11 SLC6A3 SLC6A14 SLC6A9 SLC17A6 SLC6A20 SLC17A7 SLC25A22 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR CYP11A1 FDX1 FDX2 FDXR RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 BCL2L11 FOXO3 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation TLL2 TLL1 LAMB3 COL7A1 LAMA3 LAMC2 BMP1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L POLI UBB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC14A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 CDC20 ANAPC15 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF28P KDELR1 KDELR3 SURF4 KIF5C KIF21A KIF21B KIFAP3 KLC1 KIF2A KLC4 KLC3 KLC2 NSF KIF2C KIF2B RINT1 ARF3 KIF16B KDELR2 KIF3A KIF20B COPB2 COPA TMED10 SEC22B KIF3B TMED2 KIF3C KIF5B KIF5A KIF18B KIF4B KIF4A COPE KIF12 CENPE ARF4 KIF11 USE1 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 COPB1 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 ARF1 ARF5 NAPA GBF1 NAPB NBAS RAB1A STX18 RAB1B NAPG BNIP1 ARFGAP3 ARFGAP2 ARCN1 ZW10 KIF26A KIF26B COPG2 COPG1 KIF23 RACGAP1 KIF20A KIF18A ARFGAP1 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 RBBP4 DAXX NUP37 RBBP7 PML H2AC19 DYNC1LI1 H2BC26 H2AC14 DYNC1LI2 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 H2BC17 CHMP2B VPS4A CHMP2A H2BC12 MVB12B H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 ITGB1 H3C15 H2BC9 H4C9 CHMP3 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 HNRNPK SUZ12 H2AC17 H2AC12 NUP214 TRIM28 H2AC25 H2AC21 EZH2 VPS36 VPS25 CBX1 SNF8 CHMP1A CEBPD ELK1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 ESR1 CBFB RSPO3 FOXP3 AXIN1 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX PRDM1 RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM PNP ITPA NT5E NT5C NT5C1A XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades JUN PDGFB RASGRP1 RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB PRKG2 IL2 IL3 IL6 CDC14A FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA RAC1 KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 KALRN DNAJB1 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB SHC2 HSPB1 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 XPO1 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PAK1 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP SEPTIN7 PAK2 CDC14B ARL2 RAG2 RAG1 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A ETV4 RASA3 RASA4 RASA2 ABHD17C IGF2BP1 MAPK6 MAPK4 ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR CCND3 FNTB MAP3K11 MAPKAPK5 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 CDC42EP5 FGF3 CDC42EP3 FGF4 CDC42EP2 FGF6 FOXO1 FGF7 FGF9 IL6R RASA1 PAK3 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 CDC42 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 NCOA3 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA FOXO3 PTK2 HGF EREG BTC EPGN UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases USP17L1 RNF146 TOMM20 RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 USP3 IL33 USP2 MUL1 H2AC1 TGFBR1 CDC25A FKBP8 STAM2 TNKS ADRB2 FOXO4 ATXN7 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 NFKBIA TADA3 MDM2 MDM4 TAB1 RIGI USP37 USP33 USP34 PTEN ARRB1 ARRB2 POLB USP30 USP47 USP48 USP49 USP42 USP44 TRAF2 AXIN2 H2BC18 TRAF6 BIRC2 OTUB1 BIRC3 USP13 USP14 BECN1 USP15 USP16 SKP2 USP10 USP12 HGS MAT2B CDC20 USP18 USP19 TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 PSMD1 USP17L30 HIF1A RNF123 AR AXIN1 RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 PSMA1 SNX3 RHOT1 PSMA2 RCE1 UBA52 SIAH2 PSMD12 PSMD11 TADA2B CYLD PSMD14 H2AC25 H2AC21 PSMD13 WDR48 PSMA7 PSMB6 IFIH1 PSMB7 PSMB4 UFD1 PSMB5 IKBKG UBB TOMM70 PSMB2 PSMB3 UBC PSMB1 DDB2 RPS27A KAT2A PTRH2 WDR20 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 PSMC6 SEM1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 PSMC2 USP17L18 USP17L17 TP53 CCNA2 USP9X CCNA1 USP17L19 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 POU5F1 NANOG INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNG13 GNB2 KCNJ2 KCNJ8 KCNJ3 KCNJ11 GNB1 KCNJ4 ABCC8 ABCC9 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 KCNJ1 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression PTK6 PELP1 EPAS1 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism GUSB CD44 ABCC5 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HAS1 HYAL2 HEXB HAS3 HEXA CHP1 HAS2 SPAM1 HYAL1 HYAL3 HYAL4 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud ROBO2 GFRA1 EYA1 BMP4 SLIT2 FOXC2 ITGA8 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 WNT11 ITGB1 GREM1 SALL1 SIX2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism FOLH1 FOLH1B GOT1 ASPG NAALAD2 NAT8L ASPA SLC25A12 GOT2 ASNS SLC25A13 GADL1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX2 HSD17B4 AMACR ACOX3 ACOXL CROT CRAT ACOT8 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism SLC26A2 CSPG4 CHST3 CHST14 HSPG2 PAPSS2 SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B3GALT6 B4GALT1 B4GALT7 GPC1 GPC3 GPC2 ST3GAL3 GPC5 GPC4 NCAN GPC6 HEXB CHSY1 HEXA BGN DCN PRELP CHST6 BCAN OMD EXT1 VCAN KERA SDC1 OGN CSPG5 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A4 TOMT BCHE SLC6A3 ALDH2 COMT ACHE SLC22A2 SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 GORASP2 GORASP1 USO1 CCNB1 RAB2A CDK1 MAPK1 RAB1A RAB1B GOLGA2 CCNB2 BLZF1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 EPHX2 ALOX5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 NRAS PRKCZ SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 DDX5 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ ACE2 VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 HAVCR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 PARP10 PARP6 SFTPD IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C RPS10 STAT2 CHMP4B RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CHMP2B RPS3A RPS26 CHMP2A RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N CHMP3 CHMP6 HLA-H CHMP7 RPN2 HLA-B ZDHHC20 HLA-C TUSC3 ATG14 PRKCSH HLA-F RPN1 ZDHHC5 HLA-G HSP90AB1 HLA-E MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 SDC2 DDOST SDC3 MGAT4C ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 GPC5 SUMO1 GPC4 YWHAB GPC6 TRIM25 SDC1 IKBKE AKT1 IRF7 VHL NUP214 SFN YWHAZ ISCU UBA52 IFIH1 JAK1 TRIM4 IKBKG TOMM70 UBB RIPK2 UBC TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 FURIN VCP STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C ANO8 ANO9 NUP42 NUP85 ANO6 ANO7 TPR ANO4 NUP62 ANO5 UVRAG NUP88 MAP1LC3B ANO2 ANO3 NUP43 RAE1 HSP90AA1 ANO1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 TMPRSS2 NOD1 SRPK2 ANO10 GALNT1 NOD2 AKT2 PDPK1 NRP1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 PRMT1 SRPK1 HSPG2 TJP1 CHUK PTPN11 AGRN ST6GALNAC2 SIKE1 GSK3B ST6GAL1 CSNK1A1 ST6GALNAC3 ST6GALNAC4 CREBBP ST3GAL4 ST3GAL1 ZCRB1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 SNRPG TAB3 TAB2 SNRPE CTSL IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors JUN ZNF217 EBAG9 DDX5 RXRG GPAM CXCL12 POU2F1 NOS3 TBP S1PR3 CARM1 MMP2 MED1 GTF2A1 GTF2A2 MMP3 SCD FASN HBEGF HDAC1 HSP90AB1 PTGES3 CCND1 FKBP4 ATF2 RARG JUND CYP26A1 CYP26B1 TNRC6C MOV10 CYP26C1 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B XPO1 RARB AKT1 POLR2A POLR2B GATA3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 KAT2B KPNA2 GNG10 IGF1R PGR GNG12 CAV1 GNG11 GNG13 FKBP5 GNB2 PPARD KDM4B YY1 GNB1 DHRS4 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNG3 ESR1 GNG2 GNG5 RDH5 GNG4 GNG7 GNG8 HSP90AA1 EGF EGFR CDKN1B H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 PRKCZ H2AC8 CTSD H2AC6 H2AC7 HRAS H2BC17 RUNX1 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 RARA PIK3R3 PIK3CA CBFB H3C15 RXRA CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 NRAS H2AC20 CETP KDM3A HDAC3 KDM1A MAPK1 GNAT3 KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 SRF ABCA1 MAPK3 ABCG8 KDM4A MYLIP ABCG5 NR1H2 FABP5 KCTD6 APOC4 NR1H3 NCOR2 ARL4C EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ESR2 ABCG1 SRC PDK4 GNAI3 GNAI1 GNAI2 CALM1 AXIN1 NCOA2 NCOA3 PDHB NR5A2 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 CCNT1 KAT5 KANK1 MMP9 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 FOXA1 ALDH1A3 ZDHHC7 DHRS9 TLE3 ALDH1A2 TGFA PPID ALDH1A1 USF1 FOS CAV2 ALDH8A1 GREB1 FOXO3 ELK1 CHD1 PTK2 MMP7 EREG TFF3 UHMK1 TFF1 BTC ZDHHC21 EPGN CXXC5 AKT3 DLD USF2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors LTB4R2 OXER1 PTGER4 GPR17 PTGFR PTGER1 LTB4R TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR CYSLTR1 CYSLTR2 PTGIR C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RELA MAP3K7 UBA3 UBE2M PRKACG RAF1 PRKACA PRKACB CD209 CARD11 MALT1 ITPR1 RELB CLEC10A ITPR2 CLEC7A CLEC4A ITPR3 NFKBIA CARD9 CLEC4E MAP3K14 CLEC6A TAB1 PLCG2 PYCARD CLEC4C CLEC4D TRAF6 BTRC IL1B EP300 PAK3 HRAS PPP3CA PPP3CB PDPK1 CASP8 PPP3R1 UBE2N NFATC1 MUC13 NFKB1 NRAS CDC34 NFATC2 CHUK FCER1G IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 MUC12 PRKCD MUC15 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 MUCL1 PSMA1 MUC3A LYN MUC5AC PSMA2 MUC3B UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 NFKB2 PSMA7 MUC1 PSMB6 MUC2 PSMB7 PSMB4 MUC7 MUC4 PSMB5 MUC6 MUC16 IKBKG UBB MUC17 PSMB2 PSMB3 CREBBP MUC19 UBC PSMB1 MUC5B MUC20 MUC21 RPS27A ICAM2 ICAM3 FBXW11 UBE2V1 ADRM1 PSMC5 SYK PAK1 PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 PAK2 RPS6KA5 CUL1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A EIF4G1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IFNA2 OTUD5 IFNA8 ATG5 ATG12 RELA IFNA13 IFNA14 IFNA16 IFNA17 NFKB1 HSP90AB1 UBE2K ITCH IFNA10 PIN1 IFNA21 IFNB1 CHUK ISG15 PCBP2 IKBKB RIPK1 TBK1 IRF3 NFKBIA MAVS DHX58 RNF125 TKFC TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 TRIM25 IKBKE IRF7 SIKE1 TANK TRAF2 UBE2D1 HSP90AA1 TRAF3 TRAF6 UBA52 FADD CYLD NFKB2 IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG TOMM70 UBB CREBBP UBC RPS27A CASP10 NLRX1 EP300 NLRC5 UBA7 AGER RNF135 S100A12 MAP3K1 APP S100B SAA1 HMGB1 NFKBIB CASP8 UBE2L6 IFNA5 HERC5 IFNA4 IFNA7 IFNA6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR RUNX1 ELF1 CBFB IL3 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis PNMT DDC TH DBH DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts RXRA SLCO1A2 ABCB11 NCOA2 SLCO1B1 SLC27A5 FABP6 SLCO1B3 ABCC3 ALB SLC10A1 SLC10A2 STARD5 NR1H4 SLC51A NCOA1 SLC51B BAAT DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI2 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF18 TNFRSF1B TNFSF13 TNFRSF14 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells YAP1 ITGA5 GNAQ RELA NFKB1 ABL1 CHUK CAPNS1 CAPNS2 CAPN2 STAT1 PTPN1 IKBKG PPP2R1B ANXA2 PPP2R1A IKBKB PPP2CA PPP2R2A VCL PIEZO1 NFKBIA GNA11 IKBKE PTK2 ITGB3 ITGB1 ITGAV DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NFE2L2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR PSENEN NCSTN APH1B PSEN2 PSEN1 RELA NGFR NFKB1 ADAM17 TRAF6 APH1A SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 RELA PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 MAPK1 GNA13 GNGT2 F2RL2 GNA12 F2RL3 MAPK3 F2R GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 GNG10 F2 GNG12 GNG11 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling ERBIN STUB1 HBEGF HSP90AA1 ERBB2 EGF USP8 EGFR CDC37 UBA52 MATK PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 NRG1 AKT1 EREG NRG3 NRG4 NRG2 BTC AKT3 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases YAP1 ITCH PRDM1 ITPR1 ITPR2 ITPR3 NOS3 PRR5 CHD4 NTRK1 KIDINS220 CRK REST HGS VGF JUNB PRKCB RAC1 VAV3 CRKL VAV1 VAV2 MAPKAP1 TIAM1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ARHGEF7 MAPK7 APH1A PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 SOCS1 MDK WWOX ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 HIF1A FES POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K STAM POLR2L RALA WWP1 GTF2F1 GTF2F2 RAB4A PTPN18 PTPN12 PTPN2 AAMP MKNK1 SPRY2 ALK AHCYL1 PRKCE PGR MST1 MEF2A MST1R RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 USP8 STAM2 SPHK1 CDK5 ESR1 ADAM17 CYFIP2 PTPRU SH2B2 CMA1 FER TEC GRAP RAB4B KLB FLT3 IRS1 PPP2R1B PDE3B IRS2 PPP2R1A PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 NCK2 PTPRF FGF4 FGF6 NCK1 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 DIAPH1 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 ITGB1 TLR9 PIK3C3 TRIB3 ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 GFAP ATP6V1B1 ATP6V1A SHC1 PPP2R5D PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 SGK1 FGF20 THEM4 RHOA ATP6V1H PTPRJ MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 SRF ATP6V0A1 CDK5R1 MAPK3 PTPN1 INSR PTPN11 FGF16 CDC42 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FAM83B FGF10 HNRNPM HNRNPF SRC NRG1 DOCK3 GRIN2B HNRNPH1 DLG4 CALM1 DOCK1 FLT1 FLT4 KDR VEGFB VEGFC PTK2B VEGFD THBS1 PGF VEGFA ERBB2 ESRP1 MEMO1 CTNND1 CTNNA1 BAX CSK JAK2 SPRED2 RANBP9 SPRED1 CD274 IL2RG NELFB CHEK1 MMP9 BRAF MAP2K5 NCBP1 NRP2 NCBP2 CDH5 FRS3 TNS4 TNS3 LCK FYN HGF FGFRL1 FLRT2 FLRT1 CLTC CLTA AP2A1 NTRK3 AP2A2 NTF3 PDGFB AP2M1 RAP1B RAP1A PRKACG IGF2 PRKACA PRKACB IGF1 AP2S1 CXCL12 PTBP1 AP2B1 PLG STAT5A LAMA5 SH3KBP1 PXN LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 GRAP2 LAMC1 JAK3 HNRNPA1 PDGFRA KIT PTK6 HBEGF HDAC1 FLRT3 SIN3A NAB1 CTNNB1 COL6A2 NAB2 MET COL4A4 LYL1 F3 DNM2 COL6A1 ARC COL4A3 TRIB1 PTPRK TPH1 EPS15L1 ATF2 RRAD EPN1 ASCL1 SPRY1 PTPN3 EGR1 COL6A3 EGR2 EGR3 JUND COL4A5 EGR4 COL6A6 FOSL1 COL6A5 ID2 MLST8 ID1 MYCN MEF2C ID4 FOSB ID3 MYC CDK5R2 SPINT1 TGFBR3 HPN SPINT2 HGFAC MTOR YWHAB HSPB1 LRIG1 SOCS6 SH2B3 AKT1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 NCF2 NCF4 BRK1 MAPKAPK2 UBA52 MATK GIPC1 ANOS1 CYBB CYBA UBB RAPGEF1 UBC RPS27A RNF41 CUL5 MAPK14 MAPK11 PAK1 NCKAP1L WASF1 IRS4 PAK2 IGF1R CILP WASF2 CAV1 ERBIN BAIAP2 ABI2 FURIN PCSK6 ABI1 NGF PCSK5 SPP1 RICTOR ROCK1 ROCK2 ADAM12 STAT1 ELMO1 HSP90AA1 NEDD4 EGF CBL JUP EGFR CDC37 PLCG1 STMN1 RBFOX2 PDGFD SHB FGFBP3 FGFBP1 FGFBP2 ARF6 ALKAL2 ALKAL1 TIA1 TNK2 DOCK7 ADAP1 ESRP2 PTPRZ1 CSN2 TIAL1 SH2D2A PAG1 RANBP10 PTPRO PTN AXL PLAT FAM83D FAM83A MXD4 LTK EP300 THBS4 RASA1 THBS3 PRKCZ PAK3 BCAR1 NRP1 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 NRG2 ITGAV COL4A2 COL4A1 PTPRS SPARC STAT3 HDAC3 ITGA2 GABRG3 APOE GABRG2 COL9A1 GABRB3 COL9A3 GABRB2 COL9A2 GABRB1 NCOR1 GGA3 HDAC2 STUB1 STAT5B GABRQ GABRA1 GRB2 THBS2 ATF1 GALNT3 DNMT1 MAPKAPK3 MUC20 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 PTPN6 YES1 MEF2D STAT6 NTF4 PDGFRB S100B NTRK2 BDNF TGFA TAB2 FOS ELK1 PTK2 EREG BTC EPGN AKT3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HPGDS TBXAS1 PTGES PTGES2 PTGR2 CBR1 PTGIS PTGS2 PTGS1 CYP8B1 AKR1C3 PTGES3 PTGDS HPGD PRXL2B ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX BAX BID CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 CD22 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PTPN6 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME CYP2E1 UGT2B7 CYP2C9 UGT1A3 CYP2C8 ABCC2 CYP2C19 ACSM2B ABCC3 CYP2D6 SLC16A1 SLC22A7 UGT2B28 ALB CES2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 BCHE UGT3A1 UGT2A1 UGT1A8 GLYATL3 BSG UGT1A7 GLYATL2 UGT1A6 GLYATL1 ACSM2A CYP3A4 UGT2B10 ACSM5 UGT2B11 GLYAT UGT1A1 CES1 ACSM4 UGT2B15 UGT1A9 UGT2B17 UGT2B4 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer TP53 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection CLTC KPNA7 KPNA4 KPNA5 CLTA GBP1 KPNA3 CPSF4 TGFB1 EIF2AK2 ISG15 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 KPNA1 PABPN1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 NUP37 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 MLKL RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 CALR CANX RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 XPO1 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 HSPA1A KPNA2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNG13 CLTC CLTB WNT5B FZD7 WNT5A ROR1 GNB2 ROR2 CLTA GNB1 AP2A1 PRICKLE1 WNT1 FZD1 MAP3K7 GNB4 AP2A2 RYK FZD8 GNB3 GNB5 AP2M1 GNGT1 GNGT2 PRKG2 AP2S1 GNG3 SMURF2 ITPR1 ITPR2 GNG2 ITPR3 GNG5 AP2B1 GNG4 GNG7 GNG8 ARRB2 SCRIB VANGL2 DAAM1 PFN1 PARD6A PRKCB RAC1 DVL1 DVL2 DVL3 PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 RAC2 GNAO1 TCF7L2 TCF7L1 LEF1 TCF7 RHOA CTNNB1 TNRC6C MOV10 AGO3 AGO4 SMURF1 AGO1 AGO2 TNRC6A TNRC6B CAMK2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RAC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 WNT4 PSMC1 PSMC2 PRKCG GNG10 GNG12 GNG11 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 RB1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 SKP2 ANAPC15 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 FUCA1 MGAT3 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 B4GALT6 SEC22B B4GALT5 MAN2A2 LHB SERPINA1 SEC23A COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 MANEA TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B B4GALT2 TRAPPC3 B4GALT3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A B4GALT4 TRAPPC6B CGA SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 FUT8 NSF MAN2A1 CTSC MGAT5 CAPZA3 MGAT1 MGAT2 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A MGAT4C TMED2 MGAT4A SPTB DYNC1I1 MGAT4B B4GALT1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 ST6GAL1 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ST3GAL4 ANK1 AREG ST8SIA6 DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 ST8SIA2 TGFA ST8SIA3 YKT6 ARFGAP1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation MAPK1 RAPGEF1 RAP1A FRS2 NGF MAP2K1 MAP2K2 CRKL MAPK3 BRAF YWHAB RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MBD2 MAPK3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants UBC RPS27A FLT3LG CBL UBA52 FLT3 UBB MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN CSNK2A1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects APRT HPRT1 ADA TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs KIT HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 RNF8 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e DPM3 DPM1 DPM2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope DSG1 DSG3 FURIN PERP PCSK6 LCE6A IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KLK13 KLK14 LCE3E KLK12 LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A LCE1B KAZN LIPJ LIPN LIPM JUP PRSS8 PI3 LIPK PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 LCE1E LCE1F LCE1C CAPNS1 LCE1D LCE2B PKP4 LELP1 CAPN1 LCE2C LCE2A LORICRIN FLG SPRR2E SPRR2F DSG2 SPRR2G TCHH PKP1 KLK5 KLK8 PPL CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN SPRR1A SPRR1B DSG4 CASP14 LCE5A DSP PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds UGT2B7 GSTA3 GSTA1 COMT HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM MGST3 MGST1 MGST2 GSTP1 MTRR MAT1A NNMT CYP1A2 MAT2B AHCY SLC35D1 SLC35D2 SULT2A1 TPST2 TPST1 GSTM4 TPMT AS3MT AKR1A1 GSTT2 GSTT1 ESD GSTT2B UGT1A3 GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 MAT2A GSTA5 GSTA4 CHAC1 PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 ACSM1 BPNT2 ACSM2B BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 MTR HPGDS GSTZ1 GSTO1 NAT1 NAT2 GSTA2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 UGDH UGT2B4 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 MFAP5 BMP4 MFAP4 MFAP3 MFAP2 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 BMP10 LTBP4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP41 CEP43 DYNLL1 CKAP5 TUBA1A RPGRIP1L PRKACA MAPRE1 PAFAH1B1 DYNC1I2 MKS1 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 YWHAE CEP97 CC2D2A TUBB4B IQCB1 TUBB4A KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 YWHAG SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 RAB3IP CEP290 NINL RAB11A CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins ACOX1 HSD17B4 AGPS SCP2 ACAA1 PHYH TYSND1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria YWHAH YWHAZ SFN BCL2 AKT2 YWHAB PPP3CC BID YWHAE AKT1 PPP3R1 BAD YWHAQ YWHAG AKT3 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b MOGS STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B BCL2L1 CDKN1A GRB2 GAB2 FLT3 NOX4 PIM1 PTPN11 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP5B SYNJ1 INPP5A IMPA1 MTMR9 INPP4A IMPA2 MTMR7 INPP4B INPP5J MIOX ISYNA1 OCRL INPP1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 GLYAT VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance APOC4 LSR APOB VLDLR APOBR APOC1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism MRI1 ENOPH1 BHMT2 FMO1 BHMT ADI1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 MAT1A TST ETHE1 SLC25A10 CDO1 AHCY CBS MTAP CTH MTR GOT1 APIP MTRR TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 F9 PROC F10 PROS1 PROZ F2 BGLAP GAS6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System RELA ARPC1B ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 RAB9B IRAK1 NCKIPSD MGST1 C4A CAT RETN FUCA2 DNAJC3 RAC1 VAV3 CST3 PRKCQ UBE2N VAV1 VAV2 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 NFATC2 V1-11 CPB2 CFH V1-16 V1-13 MAPK8 C5AR2 CFI CDK13 CAPZA2 C5AR1 C4B_2 C2 ACTR10 C5 HSPA1B C6 SOCS1 C7 C9 CD19 IKBKB V2-8 V1-20 MYD88 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S UBE2D2 C1R UBE2D3 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 RAB3A POLR2E POLR2F POLR2H POLR2K DNAJC5 POLR2L KRT1 TOLLIP ACTB CSNK2B CNPY3 TLR8 CTSB TP53 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B NLRC4 RAB5C BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 ACTG1 FCAR ALAD FCGR3B PPP2R1B PGM2 PPP2R1A ACP3 SNAP29 PGM1 RNASET2 TNFRSF1B DYNC1LI1 PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 TXN DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PPP2R5D PRG3 DYNLL1 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 CHUK MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA DNASE1L1 PPP2CB CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CD93 CASP1 CD300A CASP2 IRAG2 ATAD3B OSCAR TYROBP DOK3 CRCP COPB1 ADGRG3 DPP7 MGAM POLR3GL HSPA6 GGH POLR3A POLR3B DNAJC13 ADA2 POLR3C IGF2R POLR3D POLR3E SELL TARM1 POLR3F POLR3G MAN2B1 MS4A3 POLR3H DDX3X TNFAIP6 POLR3K CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 NFKB2 ADGRE5 NAPRT ADGRE3 FGB HGSNAT DYNLT1 ATP6AP2 FGA PLAUR LRRFIP1 MMP8 MMP9 FGG CHI3L1 PDXK BIN2 FCN2 CLEC12A MVP FCN3 CAND1 CRP COLEC10 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN SKP1 PROS1 F2 CUL1 AP2A2 SLC15A4 RASGRP2 RASGRP1 RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB NPC2 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 LBP IGKV3-20 IGHV4-34 IGHV1-2 ITK IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 VTN IGLC2 BTRC IGKV3D-20 TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C AMPD3 IGKV5-2 APRT IGLC6 IGKV1-5 PNP IMPDH1 IMPDH2 LIMK1 PPP3CA EEF1A1 MYH9 PPP3CB UBE2L6 HERC5 PPP3R1 NFATC1 HLA-H HLA-B HLA-C HSP90AB1 IGHE HLA-E CDC34 DNM2 ATG7 CAB39 CTSS VAMP8 TLR6 HUWE1 IKBKE LAMTOR2 IRF7 LAMTOR1 TANK LAMTOR3 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 STBD1 CEP290 NFATC3 TUBB S100A1 CYBB CYBA RAB7A UBE2V1 UBA7 UBR4 PAK1 MEFV PSTPIP1 NCKAP1L SUGT1 WASF1 PAK2 WASF2 CALM3 CALM2 RASGRP4 BAIAP2 ATP8A1 ABI2 UBA3 ABI1 UBE2K ATP11B UBE2M ATP11A TIRAP CARD11 MALT1 ATP8B4 RELB CLEC10A CLEC7A CARD9 CLEC4A WIPF1 CLEC4E MAP3K14 WIPF2 CLEC6A DHX58 WIPF3 RNF125 TAX1BP1 RNF216 FCGR1A ARHGAP45 IQGAP1 ANO6 PLD1 IQGAP2 JUP ARHGAP9 WASL WAS STOM PAK3 MYO9B MAP2K1 COLEC11 HSP90B1 ITGAV FTH1 MASP1 FTL XRCC6 XRCC5 ITGAX DGAT1 FABP5 SIKE1 GPI CD36 HK3 KLRK1 PGAM1 KIR3DS1 DHX36 PRKDC FCER1A LAT2 NCR2 BCL10 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E NKIRAS2 LPO MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 TLR10 BCL2 TLR5 ALPK1 LRRC14 NLRX1 PELI3 BCL2L1 PELI2 PTPN6 NLRC5 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 STAT6 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB ELK1 POLR1C PTK2 POLR1D IFNA5 IFNA4 IFNA7 IFNA6 JUN IFNA2 IFNA8 AGPAT2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 CD209 GM2A NOS1 APEH ARSA FGR ASAH1 PECAM1 ITPR1 ITPR2 ITPR3 PSAP TKFC APOB MBL2 NOS2 NOS3 MME GLA P2RX7 CRK P2RX1 FADD IST1 CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 KPNB1 IL1B PELI1 TLR4 GSN TICAM2 TICAM1 PKP1 LY96 SDCBP HMGB1 CASP8 CASP5 CASP4 DSP DUSP4 DSG1 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 PRKCSH MAGT1 LTA4H NCSTN ADAM10 PSEN1 DNM1 GOLGA7 LGMN DDOST LPCAT1 ALOX5 DNM3 MAPK12 MAPK13 TRIM25 HPSE LYN BTK CYLD CNN2 CFL1 IFIH1 TRIM4 IKBKG ANXA2 TOMM70 RIPK2 MIF CAPZA1 AAMP PPIA RNF135 AHCYL1 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 NFKBIA MAVS CYFIP2 TAB1 RIGI TNFAIP3 HMOX2 SLC44A2 GLIPR1 TRAF2 TEC TRAF3 TRAF6 BIRC2 BIRC3 STK10 USP14 NOD1 NOD2 USP18 ORMDL3 PIK3CB TCIRG1 PTGES2 NCK1 TNIP2 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B CD180 ATP6V0E1 LY86 ATP6V1G2 EEA1 PDPK1 TASL RBSN IRF5 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 ATP6V0D1 FAF2 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS ATP6V0A2 PLD4 ATP6V1H MAPK1 PLD3 ATP6V0A4 PANX1 DHX9 ATP6V0E2 ATP6V1G3 ATP6V1D ALDH3B1 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PCBP2 PTPN11 PLD2 DEGS1 UNC93B1 TLR3 CKAP4 LRRC7 CALM1 DOCK2 DOCK1 MOSPD2 UBE2D1 MRE11 ARMC8 MYO5A FBXW11 OPTN RAB27A CEACAM1 SEM1 APP LAMP2 PPIE ARG1 SERPING1 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 SERPINA3 DEFB117 DEFB116 ORM1 FPR2 SLC11A1 SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 ORM2 DEFB110 TLR1 DEFB130A BPI QSOX1 PRTN3 DEFB130B S100A9 CAP1 DEFB4B S100A8 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PTAFR PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 ACLY ATG5 ATG12 SLC27A2 CTNNB1 ACAA1 ATF2 TREM2 SIGIRR IRAK3 MEF2C B4GALT1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 KCNAB2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 CASP10 ICAM3 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A CASP9 APAF1 CASP3 CFD C3 GZMM CFB VAPA CCT2 ROCK1 ZBP1 TREX1 DDX41 DTX4 TBK1 B2M IRF3 STING1 AP1M1 NLRP4 TRIM32 TRIM21 TRIM56 ELMO1 HEXB GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 FRK PLCG1 EP300 NDUFC2 NFKB1 PIN1 CHRNB4 ITGAL MUC12 MUC15 PTPN4 MUCL1 MUC3A MUC5AC MUC3B LGALS3 CFP MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 NEU1 MUC5B MUC20 MUC21 CTSA YES1 EEF2 MLEC CTSV CTSL CTSK MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 TYK2 JAK2 JAK1 IL6R MAP2K2 PTPN11 IL6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability HSP90AA1 JUP CTNND1 THEM4 CTNNA1 RICTOR CTNNB1 CDH5 MLST8 AKT2 PAK1 PAK3 MTOR RAC1 VAV3 NOS3 PRR5 PDPK1 PAK2 AKT1 VAV1 CALM1 CAV1 VAV2 MAPKAP1 AKT3 TRIB3 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB GLYCTK KHK ALDH1A1 TKFC REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC VCL PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis CDON ABL1 CTNNA1 CTNNB1 MAP2K6 CDC42 CDH2 NEO1 NTN3 CDH4 BNIP2 MEF2C CTNNA2 MYOG SPAG9 MEF2B MAPK14 MYOD1 MAPK11 MYF6 TCF4 MEF2D CDH15 MYF5 TCF3 TCF12 MAPK12 MEF2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SMARCB1 SMARCD1 SMARCD2 SMARCD3 PCGF5 HIPK2 SMARCC1 SMARCC2 RYBP ARID2 YAF2 SMARCE1 ACTL6A BMI1 CBX6 EP300 RING1 AUTS2 CSNK2A1 CSNK2A2 RNF2 SMARCA2 RUNX1 ACTL6B SMARCA4 CSNK2B CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 CBFB ARID1A ARID1B PBRM1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PLK1 PSMA6 PSMA3 PSMA4 HSP90AA1 PSMA1 CCNB1 PSMA2 CDKN1A UBA52 PSMD12 HSP90AB1 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 MAPRE1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A GTSE1 FKBPL ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 CCNB2 PSMD2 TP53 PSMD3 PSMD1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation GLI2 IHH HDAC4 CBFB BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion NEDD4L CHMP3 CHMP6 CHMP7 UBA52 UBB UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A PPIA VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 PDCD6IP MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MT-ND4L GFM2 MRRF MT-CYB MTRF1 MTRF1L MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 UBA52 IFNA10 IFNA21 IFNB1 EIF2AK2 IFIH1 JAK1 UBB CREBBP UBC TYK2 RPS27A STAT2 EP300 IRF3 CUL5 IFNAR1 MAVS RIGI ELOB ELOC RBX1 TRIM25 IFNA5 IFNA4 IFNA7 IFNA6 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNJ2 KCNJ4 KCNJ14 KCNK5 KCNK2 KCNK3 KCNK12 KCNK4 KCNK15 KCNK9 KCNJ12 KCNK6 KCNK7 KCNK1 KCNK10 KCNK13 KCNK16 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 PHOSPHO1 LPIN1 LPIN2 LPIN3 CHKB ETNPPL CEPT1 CHKA ETNK2 SELENOI PISD ETNK1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME SLCO1A2 SLC22A8 ABCG2 ALB SLC22A1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling NRG1 HBEGF PIK3R1 PIK3CA NRG3 EREG NRG4 BTC NRG2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling GNAS ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System PRL FGF10 TGFA AREG EGF MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 MAPK3 BRAF UBB GALNT3 PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 FRS3 RPS27A FGF4 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling SOS1 IL15RA STAT5A STAT5B IL15 SHC1 STAT3 IL2RB SOS2 GRB2 JAK3 JAK1 GAB2 IL2RG PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation CACNG4 FGF14 FGF13 FGF12 FGF11 SCN9A SCN11A CACNG6 CACNG7 SCN10A SCN8A CACNA1C RANGRF SCN5A CACNB1 SCN4A SCN4B SCN7A CAMK2B SCN1B SCN1A CAMK2D CAMK2A CACNA2D2 CACNB2 SCN3B SCN3A CACNG8 CALM1 CAMK2G SCN2A SCN2B SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog EVC2 IQCE EFCAB7 SEL1L EVC BOC GAS1 ADCY9 DRC4 CDON ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L CUL3 PRKACA KIF7 PRKACB WDR35 IHH IFT88 VCP SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 DERL2 ERLEC1 SMURF2 OS9 ADAM17 P4HB ARRB1 ARRB2 GNAS GLI1 SUFU BTRC NUMB PRKAR1B PRKAR2B PRKAR1A PRKAR2A NOTUM SPOP GLI3 GLI2 SMURF1 GPC5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 OFD1 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 DISP2 PSMC2 ULK3 SCUBE2 GRK2 SKP1 DZIP1 SPOPL SYVN1 CUL1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 TRIM24 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 ZMYM2 FGFR1OP2 GAB2 PIK3CA MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A AJUBA YWHAG PLK1 HSP90AA1 CCNB1 CEP57 CETN2 CEP164 UBA52 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 BTRC CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 PPP1CB HAUS5 CSNK1E UBB PPP2R1A TUBG1 HAUS2 HAUS1 CPAP UBC AKAP9 RPS27A BORA CEP63 SFI1 FBXW11 SDCCAG8 OPTN DCTN2 SSNA1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 SKP1 CCNB2 ODF2 CEP152 NEDD1 ALMS1 CUL1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes ZNF420 TNFRSF10C PRELID3A BNIP3L TNFRSF10B TNFRSF10A PERP PRELID1 TNFRSF10D TMEM219 NLRC4 BAX BID BIRC5 TP63 PPP1R13B FAS CREBBP CHM BBC3 RABGGTB RABGGTA NDRG1 BCL6 CASP10 PMAIP1 STEAP3 AIFM2 TP53AIP1 TP53INP1 CRADD TP53I3 IGFBP3 TP73 TP53 CASP6 ATM CASP1 TRIAP1 CASP2 PIDD1 TP53BP2 APAF1 BCL2L14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 IGLV2-11 IGLV1-40 HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LRP1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4C GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D PLA2G4E PLA2G4A PLA2G4B CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD MC2R POMC DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins GSN SPTAN1 DBNL PLEC CASP8 CASP6 ADD1 GAS2 CASP7 MAPT CASP3 VIM REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSF1 HSPA2 MAPK3 HSPA1B HSPH1 YWHAE NUP205 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA8 RPA1 RPA2 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation MIB2 ITCH UBE2L3 BTRC RNF111 UBE2V2 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF126 CDC34 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SOCS1 HACE1 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 LRRC41 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 KLHL5 PSMA5 RLIM PSMA6 TRIP12 PSMA3 KBTBD7 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 RNF19B UBE3A PSMD12 UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 NPEPPS PSMD13 RNF19A PSMA7 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 UBE2E3 TRIM4 PSMB4 FBXO17 PSMB5 FBXO15 UBE2E2 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 RNF14 KBTBD13 CUL3 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 RBBP6 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 SMURF2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 ASB2 ASB3 SKP2 ASB1 CDC20 SOCS3 SH3RF1 FBXO32 MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 FBXL21P SEM1 SKP1 CUL1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RRAS RAC1 PLXNB1 MET RND1 ARHGAP35 SEMA4D RHOA PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling XIAP RACK1 TRAF1 ULK1 MAP3K7 USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 RBCK1 NSMAF SMPD3 SMPD2 CHUK IKBKB RIPK1 SHARPIN TBK1 ADAM17 TAX1BP1 TAB1 UBE2D2 UBE2D3 TNFAIP3 RNF31 IKBKE SPATA2 TNFRSF1A OTUD1 STUB1 UBE2L3 TRAF2 BAG4 UBE2D1 MAPKAPK2 UBA52 BIRC2 FADD BIRC3 CYLD OTUD7B IKBKG UBB UBC RPS27A USP21 TNF OPTN OTULIN TRADD TAB3 TAB2 CASP8 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK6 KCNK7 KCNK1 KCNK2 KCNK3 KCNK10 KCNK4 KCNK9 KCNK13 KCNK16 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling RELA MAP3K7 PTPN22 CARD11 MALT1 NFKBIA PTEN PLCG2 VASP ITK TRAC CD3G CD3E TRAF6 PLCG1 CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 PTPRC ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 CD4 HLA-DRB1 PAG1 HLA-DQB2 LAT PIK3CB CD101 HLA-DQB1 NCK1 WAS PAK3 PDPK1 PRKCQ PIK3CA UBE2N PIK3R2 PIK3R1 NFKB1 CDC34 PTPRJ EVL CHUK IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 ZAP70 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 INPP5D PSMA2 TRAT1 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 CSK PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB RIPK2 PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TAB2 PAK2 CUL1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE MMAA PCCA MMUT PCCB AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production RACK1 NSMAF SMPD3 SMPD2 TNF TNFRSF1A DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade RAC2 LYN RHOG PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 RHOA RHOB GP6 FCER1G LCP2 PTPN11 PIK3CB CDC42 LAT PDPN MPIG6B CLEC1B PTPN6 PRKCZ SYK RAC1 LCK FYN VAV3 PDPK1 PLCG2 PIK3R3 PIK3CA VAV1 VAV2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template PCNA UBA52 NPLOC4 POLH USP10 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1 TGIF2 CCNK SERPINE1 FURIN CCNC HDAC1 CDKN2B UBA52 MAPK1 COL1A2 CCNT1 TFDP1 MAPK3 TFDP2 UBB UBC CDK8 SP1 SMAD2 RPS27A SMAD4 CDK9 YBX1 SMAD3 EP300 SMAD7 MYC JUNB RNF111 MEN1 WWTR1 E2F4 CCNT2 E2F5 RBL1 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD MAT1A MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation TYK2 JAK2 JAK1 MAP2K1 IL6R MAPK3 CDK1 PTPN11 IL6 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis NEU1 GLB1 CTSA FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation FGF18 FGF1 FGF9 FGF20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism RXRA OSBP NCOA2 AMACR SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 SLC51A NCOA1 SLC51B CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 SLCO1A2 OSBPL1A ABCB11 AKR1C1 FABP6 ABCC3 AKR1C2 ALB AKR1C4 SLC10A1 SLC10A2 CYP8B1 STARD5 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2E1 CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 PSIP1 HMGA1 OPSINS%REACTOME%R-HSA-419771.3 Opsins OPN1MW OPN1LW RHO OPN1SW OPN4 OPN3 RRH RGR OPN5 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type CSPG4 AGRN B4GALT7 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 PATL1 EDC3 EDC4 DCP1B XRN1 DCP2 DCP1A LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DDX6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells HNF1A MAFA RFX6 IAPP FOXA3 GCK FOXO1 PDX1 INS NKX6-1 AKT2 PAX6 SLC2A2 HNF4G AKT1 FOXA2 NEUROD1 NKX2-2 AKT3 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing SNRNP200 SNRPD2 SRSF6 SNRPD1 SRSF7 SNRPD3 SNRPB PRPF8 ZMAT5 RNPC3 ZRSR2 DDX42 YBX1 SRSF1 DDX23 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E POLR2F POLR2G POLR2H SF3B1 POLR2I POLR2J POLR2K POLR2L GTF2F1 SNRNP40 GTF2F2 PDCD7 SNRNP48 EFTUD2 NCBP1 NCBP2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRPG SRSF2 SNRPE SNRNP25 SNRPF CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN TNKS2 TNKS FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm SOX17 SMAD2 SMAD4 GSC SMAD3 MIXL1 TCF7L2 CDH1 GATA6 TBXT EOMES CXCR4 CTNNB1 GATA4 FOXA2 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway MAP3K7 TRAF6 BIRC2 BIRC3 CYLD ITCH CHUK NOD1 MAP2K6 NOD2 IKBKG RIPK2 IKBKB IRAK1 UBE2V1 CARD9 AAMP MAPK14 IRAK2 MAPK11 TAB1 TAB3 TNFAIP3 TAB2 MAPK12 CASP8 MAPK13 CASP1 CASP4 CASP2 CASP9 UBE2N GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 TAS2R16 FZD8 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 TAS2R46 RXFP4 MRGPRD FZD10 RXFP1 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R SSTR1 CGA SSTR2 WNT16 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 PTHLH CNR2 CNR1 TSHR ACKR1 C5AR2 C5AR1 C5 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 TSHB PF4 TAS1R2 TAS1R1 TAS1R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 LHB ADORA2B GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CRH WNT3 WNT8A WNT8B NPY CXCR1 CXCR2 OPRM1 OPRK1 POMC CXCL1 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CCR5 CXCR6 CCL7 CXCR4 CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 EDN1 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH CYSLTR2 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 HTR2B HTR2C ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 WNT3A WNT9A C3 SMO PTCH1 OPN1LW OXER1 OPN1MW RHO RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 SAA1 MC2R DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth COL4A2 CACNA1D NCAM1 COL4A1 SOS1 NRAS MAPK1 COL6A2 COL4A4 COL6A1 COL4A3 MAPK3 PTPRA CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 SPTB COL6A5 AGRN NCAN SPTBN4 SPTBN5 SPTBN2 PRNP ARTN GFRA1 GFRA2 GFRA4 NRTN CACNA1C SPTAN1 SPTA1 CACNA1S PSPN GDNF CNTN2 ST8SIA4 HRAS FYN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PTK2 SPTBN1 RPS6KA5 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses IFNA2 IFNA8 IFNA13 MAP3K7 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 STAT1 SAR1B NLRP3 SEC23A TBK1 B2M LARP1 IRAK1 IRF3 IFNAR1 STING1 MAVS HLA-A TLR1 TKFC G3BP1 TAB1 G3BP2 RIGI MBL2 CNBP TLR2 NUP205 POM121 NUP107 SFTPD NUP188 IL17RC IL17RA SEC24B AAAS NLRP12 NUP160 SEC24A IL17F POM121C IL17A NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 TRAF3 RANBP2 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C TLR7 NUP37 NOD1 NOD2 STAT2 UBE2N PIK3C3 MASP1 HLA-H PIK3R4 HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E CHUK PTPN11 IKBKB TRIM25 IKBKE IRF7 SIKE1 NUP214 IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 CREBBP TYK2 UBE2V1 PTPN6 IRAK2 RNF135 TAB3 TLR8 KPNA2 TAB2 IFNA5 IFNA4 IFNA7 IFNA6 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R2A BANF1 SIRT2 CCNB1 VRK1 CDK1 ANKLE2 LEMD2 EMD LBR LMNB1 CCNB2 KPNB1 LEMD3 PPP2R1A SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy TUFM UVRAG MAP1LC3B VPS41 VPS33B VPS39 VPS18 VPS45 VPS11 VPS16 VPS33A ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity RPS6KA1 HDAC1 LEF1 ZIC1 FOXD3 MAPK1 HINT1 TFE3 MITF TFEC ALX3 TBX3 CTNNB1 MAPK3 EDNRB EPRS1 ID1 CDH1 UBE2I SUMO1 PAX3 YWHAB YWHAE XPO1 SNAI2 GSK3B TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 YWHAZ POMC RARS1 WNT3A SOX10 LARS1 MARK3 AIMP1 AIMP2 QARS1 MARS1 MC1R MC4R DARS1 EEF1E1 MC3R CREBBP KARS1 POU3F2 IARS1 TFEB EP300 MC5R SOX2 SOX9 SIRT1 KIT AKT3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 DVL3 CCDC88C CXXC4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing OGG1 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli YAP1 COX5B COX5A RELA COX6C COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C IL6 YWHAE PRR5 EED CAT PDIA6 IGFBP7 SOD2 WFS1 CARM1 PRKCI DNAJC3 MED1 MAPKAP1 PRDX2 PRDX1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 DNAJA4 DNAJA2 CAPZA2 FKBP4 ACTR10 HSPA1B IKBKB SQSTM1 UBE2D2 UBE2D3 HIF3A LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP CDKN2B CSNK2A1 IGFBP1 CSNK2A2 CSNK2B TP53 GNG10 PGR GNG12 GNG11 GNG13 FKBP5 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 MAP2K6 PRDX6 MT2A MT1A MT1M MT1F MT1G MT1H MT1X MT4 MT1B MT3 MT1E GNG3 GNG2 GNG5 CLEC1B GNG4 GNG7 GNA11 GNG8 GSTP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 SMARCD3 NUP210 HMGA1 CACNG7 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 RBBP4 NUP37 RBBP7 TXNRD1 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 COX7A2L TXN RPS27 ITGB1 CITED2 VENTX PPP2R5B DYNLL1 DYNLL2 HBB NFYA NFYB NFYC CHUK DYNC1I2 BMAL1 PPP2CA COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 HM13 EIF2AK3 NOX4 FLT4 KDR HSPA6 HSPD1 VEGFA TLN1 VCL CDH5 PIEZO1 FYN SKP1 CCNA2 CCNA1 CUL1 CXCL8 MTF1 NUDT2 CREB3L3 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 CHD6 PRKACG GPX3 GPX6 PRKACA GPX5 PRKACB GPX8 GPX7 BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 TRPV4 BTRC RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A GCN1 RPS16 WDR59 RPS19 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT DEPDC5 RPS10 RPS13 KPTN WDR24 RPS12 SH3BP4 RPS9 RPS7 FNIP1 RPS8 FNIP2 PRKAR1B KICS2 RPS5 PRKAR2B CASTOR1 RPS6 PRKAR1A CASTOR2 RPSA PRKAR2A RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 CACNB2 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 HSP90AB1 PRKAA2 SEC31A RPTOR CALR MLST8 SLC38A9 ID1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD AKT1S1 IKBKE LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NCF1 NCF2 NCF4 BAG4 ACTR1A CYBB CYBA DCTN2 CUL7 DCTN3 PGRMC2 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A HSPH1 HYOU1 HBA2 RAMP2 CALCRL ADM ITGB3 HSP90B1 ITGAV ITGA5 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 BMI1 RPL22 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RNF2 RPL12 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 MAP2K3 MAP2K4 CREBBP MAPKAPK3 SP1 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 MAP2K7 MAPK10 FOS FOXO3 PTK2 AKT3 HIKESHI JUN CCAR2 DNAJC2 CXXC1 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 ADCY9 BAG5 DNAJB6 ADCY4 BAG2 ADCY3 BAG3 ADCY2 BAG1 ADCY1 HSPA4 ST13 ADCY8 ADCY7 HSPA7 HSPA12A ADCY6 HSPA12B ADCY5 IFNB1 CSRP1 SNCB PECAM1 GCLC GCLM APOB NOS3 GSK3A P2RX7 GNAS CDKN2D CDKN2C DNAJB11 IL1A FBXL17 BACH1 TLR4 SLC7A11 LY96 OMA1 MAPK7 ADD1 ATF6 CRYAB MAP3K5 DELE1 HERPUD1 MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 KEAP1 AR NRF1 NPLOC4 RPLP0 UBXN7 DPP3 HSPA9 UFD1 IKBKG ANXA2 TALDO1 SOD1 PIK3CD CAPZA1 FKBP14 GOSR2 GPX1 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 KLHDC3 DDX11 WIPI1 YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP NLRP3 ESR1 NFKBIA MDM2 MDM4 GJA1 HMOX2 PKN2 STIP1 PIK3CB TCIRG1 CAPZB AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 PDPK1 PIK3CA ATP6V1B2 EPO TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 CACNA2D1 PIK3R2 ABCG2 ATP6V1H MAPK1 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MAPK3 PTPN1 CACNB1 CACNB3 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 HSPE1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN PPP2R2A RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 ATM ATR HSPA5 HSBP1 HSF1 ATP7A DEFA5 CAPNS1 CAPNS2 CAPN2 ATOX1 STOML2 PHB2 YME1L1 P2RY2 CDKN1A CDKN2A SIN3A CDK2 CTNNB1 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 ATF3 ATF4 TNRC6C MOV10 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B PSMD8 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 NUP214 DIS3 IDH1 PRKCD PSMA5 PPARGC1A PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 DCP2 PSMD12 SERP1 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 SIRT1 HSPA1A SIRT3 MMP14 PPARA CYCS SPP1 RICTOR CUL3 STAT1 TRIM21 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 HIGD1A H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KDM6B H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 NFKB1 H2AC20 HDAC3 NRIP1 COX4I1 COX4I2 TBL1X NCOA1 ARNT NCOR2 NCOR1 TBL1XR1 CRTC2 CRTC3 CRTC1 CLOCK NPAS2 HELZ2 RAI1 CHD9 TGS1 MEF2D COX7B GFPT1 COX7C EDEM1 COX8A SYVN1 COX8C INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling SOS1 SHC1 IL5 IL3RA PIK3R2 INPP5D IL2RB PIK3R1 JAK3 JAK2 JAK1 IL2RG CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 INPPL1 GAB2 PIK3R3 PIK3CA IL2RA IL5RA CSF2RB CSF2RA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex UBC TAB3 RPS27A TAB2 MAP3K7 TRAF6 UBA52 IRAK2 UBB TAB1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors HCAR3 HCAR1 HCAR2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants ERBIN HSP90AA1 ERBB2 CDC37 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor GNG13 GNB2 GNB1 GNAS GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNG10 PTGIR GNG12 GNG11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD MMACHC MMADHC DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis RIPK1 RPTOR MLST8 PIK3R4 NFKBIA ATG14 RETREG1 MTOR RICTOR BECN1 TAOK1 PRR5 DAXX NFKBIB PIK3C3 MAPKAP1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK H2AC20 ERCC6 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MYBBP1A ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs BRCC3 UBA52 H2AC20 STAM H2AC1 PSMD14 H2AC25 H2AC21 STAMBP ABRAXAS1 BRCA1 BABAM1 BABAM2 ABRAXAS2 UIMC1 UBB NLRP3 BARD1 UBC H2AC19 H2AC14 RPS27A KAT2B EP300 H2AC8 H2AC6 H2AC7 STAMBPL1 H2AC17 H2AC12 MYSM1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells KLF4 NR5A1 DPPA4 SMAD2 FGF2 SMAD4 STAT3 SALL4 POU5F1 SOX2 NANOG PRDM14 FOXD3 CRIPTO PBX1 LIN28A ZIC3 HIF3A ZSCAN10 EPHA1 EPAS1 SALL1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM KCTD6 RUNX1 ESR1 CBFB AXIN1 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors FSHR CGA GPHA2 LHB TSHB GPHB5 LHCGR TSHR GNRH2 GNRHR2 GNRH1 FSHB GNRHR DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands DLL1 SIN3A BDNF CRH HDAC1 SST SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 NTRK1 STAT3 NGF NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 PDYN POMC GNGT2 GNG10 OPRM1 GNG12 GNG11 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 CD9 ZP3 ZP2 ZP4 HVCN1 SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors LPAR4 GPR17 P2RY12 P2RY6 P2RY13 P2RY10 P2RY2 P2RY11 P2RY14 P2RY1 P2RY4 LPAR6 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 FGF9 NRAS FGF20 HRAS FGF23 FRS2 PTPN11 FGF16 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB PDPK1 AKT2 THEM4 TRIB3 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMA5 LAMA2 DRP2 DMD LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 UTRN SNTG2 DAG1 SGCE SGCD AGRN SGCA SGCB SGCG SNTA1 SGCZ DTNA DTNB SSPN SNTB1 SNTB2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBC GBP1 RPS27A UPK1A EPCAM UBA52 HBB GBP2 GBP6 UBE2D2 GBP4 HBA2 CASP4 CALM3 CALM2 CALM1 UBB TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TRAF2 LTA TRAF3 TNFRSF12A TNFSF12 MAP3K14 BIRC2 TNFRSF13C TNFRSF11A BIRC3 CD40LG LTBR LTB TNFSF13B TNFSF11 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression RXRA NCOA2 SERPINE1 NCOA6 SMARCD3 TBL1X CARM1 BMAL1 NCOA1 CLOCK NPAS2 HELZ2 CREBBP BHLHE40 CHD9 BHLHE41 NAMPT KLF15 TBL1XR1 AVP NOCT MED1 TGS1 F7 BMAL2 PPARA REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors SFN YWHAZ FOXO6 FOXO3 FOXO1 AKT1 AKT2 FOXO4 YWHAQ YWHAG YWHAB AKT3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation MET HGF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency ACAT1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis CHST2 B4GALT4 CHST3 B3GNT3 ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 PRELP CHST6 OMD KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis PPIA BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol DDX21 NOP56 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 PELP1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 DDX49 RPS28 DDX47 RPS29 WDR3 FCF1 RPS20 FAU RPS21 PWP2 RPS24 RPS27 RPS23 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 RPP30 UTP25 HEATR1 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 RPP38 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 RPP21 UTP4 RPP25 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 RPP40 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPP14 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L DIS3 RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EBNA1BP2 EXOSC7 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E NOB1 EXOSC4 RIOK2 RIOK1 TEX10 SENP3 EXOSC9 MTREX GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 NCL PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines DHFR SLC46A1 SHMT1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 MTHFD1L MTHFD2 SHMT2 MTHFD2L SLC25A32 FOLR2 SLC19A1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins APBB1IP SOS1 TLN1 FN1 SRC RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate TBX6 POU3F1 WNT3A ZEB2 SOX2 FGF8 ZNF521 SOX1 GBX2 OTX2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD PRELP OMD KERA ACAN OGN ST3GAL3 LUM GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XRCC1 POLE4 CUL4A RPA3 PPIE POLE2 POLE3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex H2BC9 H2AZ2 H4C9 H2BC8 BCL9L H2BC5 RUVBL1 H2BC3 H3-4 PYGO1 TCF7L2 H2BC1 BCL9 PYGO2 TCF7L1 HDAC1 H2AC20 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 ASH2L MYC TRRAP DPY30 WDR5 CDC73 AXIN2 LEO1 RBBP5 KAT5 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 TERT EP300 H3-3B MEN1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 SMARCA4 RUNX3 H2BC13 H2BC14 TLE3 H2AJ H2BC15 H2BC11 H3C15 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF NTRK3 LRRC4B IL1RAPL2 PPFIBP1 PPFIBP2 PPFIA1 PPFIA4 SLITRK3 PPFIA3 PPFIA2 SLITRK5 SLITRK2 SLITRK1 IL1RAPL1 SLITRK4 SLITRK6 PTPRD DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA ABAT ALDH5A1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 MAPK14 GNG7 GNA11 GNGT1 GNG8 GNGT2 GNG10 P2RY1 PLA2G4A GNG12 GNG11 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones DUOX1 TPO TPH2 IYD ASMT DUOXA1 CGA AANAT DUOXA2 DUOX2 TSHB PNMT DDC TH DBH DIO1 TPH1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy ACY1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) GUSB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) GRM8 TAS2R4 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GABBR2 TAS2R50 GABBR1 TAS2R19 TAS2R42 TAS2R45 TAS2R40 TAS2R60 TAS2R41 TAS2R43 CASR TAS2R46 TAS1R2 TAS1R1 TAS1R3 TAS2R30 TAS2R7 TAS2R31 GRM1 GRM5 TAS2R38 TAS2R8 TAS2R39 TAS2R20 GPRC6A TAS2R9 GRM3 GRM2 GRM4 GRM7 TAS2R1 GRM6 TAS2R3 TAS2R5 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER ACTR5 RAD23A YY1 ACTR8 RUVBL1 RAD23B PARP1 CETN2 UBA52 INO80 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ACTB UBB TFPT ACTL6A UBC RPS27A DDB2 PARP2 DDB1 COPS7B XPC COPS7A CUL4A COPS3 RBX1 COPS6 COPS5 MCRS1 NFRKB COPS8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations DAG1 POMT2 POMT1 POMGNT1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling ERBIN HSP90AA1 ERBB2 CDC37 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling YWHAZ SOS1 CRK STAT5A STAT5B SHC1 IL5 LYN IL3RA PIK3R2 CBL INPP5D IL2RB PIK3R1 TEC BLNK JAK3 JAK2 PRKACA JAK1 IL2RG PTPN11 CSF2 PIK3CB RAPGEF1 PIK3CD PTPN6 IL2 YES1 HCK IL3 SYK FYN INPPL1 GAB2 PIK3R3 CRKL PIK3CA IL2RA IL5RA VAV1 CSF2RB CSF2RA EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation EEF1B2 EEF1A2 RPL4 RPL5 RPL30 RPL3 EEF1G RPL32 RPL31 RPLP1 EEF1D RPL34 RPL10L EEF1A1P5 RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DBT DLD REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL CRIPTO ACVR1B LEFTY2 ACVR2B LEFTY1 ACVR2A CRIPTO3 ACVR1C DAND5 CFC1 CER1 NODAL SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR EIF2AK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages PRL FGF10 LAMA5 FGF2 LAMA2 LAMB3 AREG LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN TGFA REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 EHMT1 SETD9 UBC RPS27A PRMT5 EP300 UBA52 MDM2 MDM4 CHEK2 TTC5 JMY SMYD2 TP53 ATM KMT5A UBB EHMT2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FZR1 BTRC PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPOP PSMD12 PSMD11 PSMD14 PSMD13 CCND1 CUL3 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 CSNK2B PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 YWHAG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 RIPK3 CASP8 MLKL WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 DVL2 CSNK2B DVL3 CSNK2A1 CSNK1E PIP5K1B CSNK2A2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling WWP1 UBC RPS27A NEDD4 UBA52 SRC UBB ITCH SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R4 GNG13 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism GYG1 GBE1 UBA52 PYGM GYS1 GYS2 PHKG1 PHKG2 GYG2 EPM2A AKR1E2 PHKA1 PHKB PHKA2 PPP1R3C NHLRC1 GAA UBB PYGB PYGL UBC PGM1 RPS27A UGP2 AGL CALM1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling GNG13 GNB2 HBEGF GNB1 GNB4 PIK3R2 GNB3 PIK3R1 PRMT1 GNB5 NRAS GNGT1 MAPK1 GNGT2 GNAT3 CCND1 SPHK1 SRF MAPK3 GNG3 ESR1 GNG2 GNG5 GNG4 GNG7 ESR2 SRC GNG8 GNAI3 NOS3 XPO1 GNAI1 GNAI2 AKT1 CALM1 HSP90AA1 EGF EGFR CDKN1B S1PR3 MMP9 STRN MMP2 BCL2 AREG AKT2 PRKCZ HRAS MMP3 ZDHHC7 PDPK1 TGFA FOS CAV2 FOXO3 ELK1 IGF1R GNG10 MMP7 PTK2 EREG PIK3CA PIK3R3 UHMK1 BTC ZDHHC21 CAV1 GNG12 EPGN AKT3 GNG11 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling PITPNA TRPC7 TRPC5 DCC TRPC6 NTN1 TRPC3 TRPC4 TRPC1 PLCG1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction NEB DMD MYH3 MYH8 MYH6 TNNI1 TNNI2 TNNI3 TMOD3 TPM4 TPM3 DES VIM ACTN3 ACTN2 MYL4 MYL1 MYL2 MYL3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TPM2 TMOD4 TTN TPM1 TMOD2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA YY1 TFAP2A VEGFA ERBB2 TFAP2B ESR1 EGFR TFAP2C CGB8 TGFA KIT ATAD2 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RBM8A PRKACG PRKACA CXCR4 PRKACB ETF1 GSPT2 GSPT1 CXCL12 UPF3A CAP1 UPF2 LDB1 VASP CAP2 ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RAC1 RPSA PRKAR2A RPS3A RPS26 RPS25 PPP3CB RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 SOS2 HOXA2 FLRT3 ZSWIM8 MSI1 LHX3 LHX2 LHX4 LHX9 COL4A5 NELL2 GPC1 PSMD8 PSMD6 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 CUL2 PSMD1 PRKCA ROBO2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ARHGAP39 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SLIT1 UBC PSMB1 SLIT3 RPS27A ADRM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABL2 EIF4G1 PAK2 PAK4 ABL1 ISL1 DCC NTN1 USP33 SRGAP3 SRGAP1 NCK2 NCK1 PFN1 PFN2 PAK6 PAK3 PAK5 MYO9B SRGAP2 NRP1 EIF4A3 RPS27 SOS1 MAGOH RPL4 RHOA RPL5 RPL30 RPL3 RPL32 RPL31 EVL RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 CDC42 RPL38 RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 CLASP1 RPL22 CLASP2 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 SRC RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 AKAP5 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 CASC3 NCBP1 NCBP2 SEM1 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g ALG12 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 PSMD1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions KDELR1 YBX1 LYN NCL FURIN CLINT1 TSG101 GBF1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L CCNT2 TAF4B ELOB ELOC CCNH POLR2A CDC73 TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 TAF15 GTF2H2 LEO1 TAF12 GTF2H3 TAF13 SUPT5H PAF1 GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 TAF10 SUPT6H IWS1 EAF1 EAF2 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair LIG1 FEN1 PARP1 PARP2 POLB PARG APEX1 ADPRS FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion GNA14 GNAQ CD36 GNA15 PLCB3 PLCB1 FFAR1 PLCB2 ACSL4 ACSL3 GNA11 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification RCC1L RPUSD4 NGRN RPUSD3 TRMT61B TRUB2 MTERF3 SLIRP MTPAP FASTKD2 LRPPRC INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 CDC42 RAC1 SRGAP2 SRGAP3 ARHGAP39 SRGAP1 SLIT2 ROBO1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 NPLOC4 POLH RPA3 VCP SPRTN UFD1 UBB DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT GALT SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis TBX6 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 LEF1 PSMD11 PSMD14 PSMD13 PSMA7 CTNNB1 PSMB6 PSMB7 PSMB4 PSMB5 MESP2 DLL3 PSMB2 HES7 PSMB3 MSGN1 RBPJ RIPPLY2 PSMB1 LFNG ADRM1 EPHA4 PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 NOTCH1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F PIK3R1 POLR2G POLR2H NRAS PLCG1 POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 PIK3CA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription CREBBP FLT4 RBPJ MAML2 MAML1 SMAD3 KAT2B HEY1 KAT2A ACTA2 HES1 SNW1 EP300 HEY2 HES5 MAMLD1 MAML3 NOTCH2 NOTCH1 NOTCH4 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RELA MAP3K7 PIK3R2 PIK3R1 NFKB1 CDC34 CHUK IKBKB CARD11 MALT1 NFKBIA UBE2D2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 TRAC PSMA2 INPP5D CD3G TRAT1 CD3E TRAF6 CD3D UBA52 TRBV12-3 PSMD12 TRAV29DV5 PSMD11 TRBV7-9 BCL10 TRBC1 PSMD14 BTRC HLA-DQA2 PSMD13 HLA-DQA1 HLA-DPA1 PSMA7 HLA-DRB5 TRAV19 PSMB6 HLA-DRB4 PSMB7 HLA-DPB1 PSMB4 TRAV8-4 HLA-DRA PSMB5 IKBKG CD4 HLA-DRB3 UBB HLA-DRB1 RIPK2 HLA-DQB2 PSMB2 PIK3CB PSMB3 HLA-DQB1 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 LCK SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 PDPK1 TAB2 PRKCQ PIK3CA UBE2N CUL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription JUN HDAC1 HDAC3 KDM1A MAPK1 MBD3 MAPK3 ATF2 EGR1 GATAD2B GATAD2A RPTOR MLST8 CHD3 SLC38A9 BMI1 CBX6 RING1 HDAC2 MTOR RNF2 RRAGA RRAGC SUZ12 CBX8 PHC2 RHEB RRAGB PHC1 NR2E1 RRAGD CBX4 CHD4 LAMTOR2 CBX2 LAMTOR1 PHC3 SNAI2 LAMTOR4 LAMTOR3 LAMTOR5 MECOM RCOR1 ATN1 EED SALL4 MAF1 HDAC5 MTA2 HDAC7 RBBP4 EZH2 MTA1 REST MTA3 RBBP7 SNAI1 TP53 PPARG CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 RXRA CYCS PTK6 COX5B COX5A STAT3 COX6C HBB HDAC3 SIN3A COX4I1 COX4I2 BLVRB TBL1X COX6A1 BLVRA NCOA1 COX6A2 FABP1 MT-CO1 NLRP3 COX6B2 COX6B1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 HIGD1C ABCC1 ALB HBA2 TXNIP HMOX1 MT-CO2 MT-CO3 HM13 HMOX2 NCOA2 NCOA6 SMARCD3 CARM1 BACH1 HELZ2 CREBBP CHD9 MAFK NFE2L2 MED1 TGS1 STAP2 COX7A2L COX7B COX7C COX8A COX8C PPARA PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNG CHRNE CHRNA6 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions ITGA3 ITGA6 ATP1B3 PPIL2 ATP1B2 ATP1B1 SLC16A8 MMP1 SPN SLC16A3 SLC3A2 SLC7A11 SLC7A10 SLC16A1 MAG PPIA BSG SLC7A5 SLC7A6 ITGB1 SLC7A7 CAV1 L1CAM SLC7A8 SLC7A9 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling TYK2 IL23R STAT4 JAK2 IL12B STAT3 IL23A IL12RB1 P4HB DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage APRT DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PFKFB2 PRKACG PFKFB1 PFKFB4 PRKACA PFKFB3 PPP2R5D PRKACB PPP2R1B PPP2R1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RHOC H2AC20 RHOA RHOB KDM1A PPP1R12B PPP1R14A KLK3 KLK2 KDM4C YWHAB YWHAE MYL9 YWHAQ YWHAG AR YWHAH PKN3 YWHAZ SFN NCOA2 CDC25C PKN2 PKN1 PPP1CB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 PPP1R12A H2AC6 H2AC7 PAK1 RAC1 H2BC17 MYL12B H2BC12 MYL6 H2BC13 MYH9 H2BC14 MYH14 H2AJ MYH11 PDPK1 H2BC15 MYH10 H2BC11 H3C15 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis UBC PGM1 GYG1 RPS27A GBE1 UBA52 GYS1 GYS2 UGP2 GYG2 EPM2A PPP1R3C NHLRC1 UBB APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC16 ANAPC7 UBE2C UBC UBE2E1 UBE2D1 RPS27A ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC20 UBB ANAPC15 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions CACNA1D NCAM1 COL4A2 GFRA1 COL4A1 GFRA2 GFRA4 NRTN CACNA1C CACNA1S PSPN COL6A2 COL4A4 COL6A1 GDNF COL4A3 CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 CNTN2 COL6A6 COL9A2 ST8SIA4 COL6A5 AGRN NCAN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PRNP ARTN GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP5 YWHAZ GP9 RAF1 PIK3R1 VWF FLNA GP1BA GP1BB SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol RXRA ACOX2 ABCB11 NCOA2 AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 ACOT8 BAAT HSD3B7 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall IGHV3-23 IGLV IGLV2-8 SELP IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 SLC16A8 IGKV1D-39 PECAM1 SLC16A3 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SLC16A1 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 APOB IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 IGLC1 PPIL2 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MMP1 IGKV1-33 SLC3A2 IGLC7 SLC7A11 IGHV3-53 SLC7A10 EPCAM IGKV5-2 IGLC6 IGKV1-5 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 SDC1 LYN INPP5D DOK2 GP6 PF4 MIF PPIA CAV1 ITGA3 JAM2 ITGA6 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 OLR1 SPN VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 PSG9 FCAMR PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD ANGPT4 ANGPT2 MERTK CD2 CD244 PLCG1 ITGAM ITGB2 PIK3CB F11R HRAS SIRPG GRB7 PIK3CA ITGB3 ITGB1 L1CAM ITGAV ITGA5 SOS1 TNFRSF10B SHC1 TNFRSF10A PIK3R2 PIK3R1 TNFRSF10D NRAS ITGAX FCER1G ITGAL CEACAM3 CEACAM6 PTPN11 CEACAM8 CD47 TSPAN7 CD44 ITGA4 CD58 PICK1 SIRPA SELL TREM1 PTPN6 CEACAM1 YES1 LCK FYN PROC BSG PROS1 F2 IGHA1 GAS6 IGHA2 JCHAIN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 SOS1 NCK2 SOS2 NCK1 SLIT2 ROBO1 PAK6 PAK1 PAK3 RAC1 PAK5 PAK2 PAK4 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling ACVR2A INHBA INHA TGFBR3 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling PTPN7 PTPN5 IL18R1 PTPN2 PTPN4 SIGIRR SMAD3 STAT3 TBK1 PTPN6 PTPN13 PTPN20 PTPN23 IL18BP CASP1 PTPN18 IL37 PTPN12 PTPN11 PTPN14 PTPN9 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle ERBIN MPP7 VANGL1 ARHGAP32 RHOG ARHGEF5 PIK3R1 ESYT1 ARHGEF26 KALRN ELMO2 MCF2 CDC42 DOCK5 DOCK4 ARHGDIG ANKLE2 DOCK3 ARHGDIA SHMT2 LAMTOR1 NDUFS3 CYFIP1 DOCK2 DOCK1 TFRC PLD1 IQGAP2 STX5 ARHGAP1 HSPE1 ARHGAP39 LETM1 ARHGAP5 ARHGAP35 OPHN1 STBD1 ARHGDIB MAP3K11 EMD LBR TMPO PLEKHG3 VRK2 LEMD3 DEPDC1B ARFGAP3 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO ITSN1 ARHGAP21 PREX1 LMAN1 MCF2L PGRMC2 NDUFA5 VAV3 VAPB KTN1 PAK2 YKT6 ARHGEF16 PAK4 DIAPH3 ITGB1 VAV1 VAV2 CAV1 MCAM REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 SIN3A RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RELA DDX5 NPM1 ITCH VCP NLRP3 ACE2 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 MAVS TKFC RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI PARP10 PARP6 SFTPD GSK3A PARP4 PARP16 YWHAQ PARP9 PYCARD PARP14 YWHAG PARP8 YWHAH UVRAG MAP1LC3B PPIB TRAF3 TRAF6 RB1 BECN1 TLR7 RIPK3 TMPRSS2 RPS4Y2 KPNB1 RPS27L GALNT1 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C HNRNPA1 RPS10 CHMP4B EP300 RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RUNX1 CHMP2B RPS3A RPS26 CHMP2A EEF1A1 RPS25 RPS28 RPS29 PDPK1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PIK3C3 CHMP3 CHMP6 CHMP7 PIK3R4 NFKB1 BST2 PRKCSH GANAB MGAT1 MOGS PCBP2 CANX UBE2I SUMO1 YWHAB FKBP1A ST6GALNAC2 TRIM25 CASP1 IKBKE SIKE1 VHL GSK3B ST6GAL1 SFN YWHAZ UBA52 ST6GALNAC3 ST6GALNAC4 IFIH1 UBB TOMM70 UBC SP1 ST3GAL4 RPS27A BCL2L1 ZCRB1 ST3GAL1 ST3GAL2 ST3GAL3 PPIA IRAK2 PSMC6 KPNA2 CTSL PPIH PPIG CAV1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals DCC UNC5A NTN1 UNC5B SRC UNC5C PTPN11 UNC5D REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBC RPS27A TICAM1 TLR3 TBK1 TRAF3 IKBKE OPTN UBA52 TANK UBB PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy MAP1LC3A VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN TOMM40 UBE2D2 UBE2D3 MTERF3 PINK1 UBE2N VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism FASN PDZD11 SLC5A6 PANK4 VNN1 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP1 ENPP2 ENPP3 SLC25A42 AASDHPPT RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking RAB14 RAB27B TRAPPC4 RAB9A RAB6B RAB9B RAB39A YWHAE MAP1LC3B RAB33B RAB31 RAB5B RAB5C RAB3IP RAB11A RAB6A ARF6 RAB1A TRAPPC1 RAB1B RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 SYTL1 GAPVD1 RIC1 RAB32 RAB35 TBC1D24 RGP1 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB3GAP2 TRAPPC2L DENND6A RAB10 RIN1 TBC1D20 RIN2 RAB3GAP1 GABARAP TBC1D13 RAB18 TBC1D14 TBC1D17 TRAPPC2 TBC1D15 TBC1D16 TRAPPC3 ANKRD27 TBC1D10C DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B TRAPPC8 MON1A MON1B TRAPPC6A DENND1C TRAPPC6B DENND1B GDI1 ULK1 DENND1A RAB8B DENND2D TRAPPC10 DENND2C DENND2B DENND2A RAB3IL1 RAB33A TBC1D2 GDI2 RABEP1 TBC1D3 TBC1D7 RAB7B RABGAP1 DENND3 RAB21 ALS2CL CHML RAB11B RAB12 RAB13 CHM GGA2 GGA1 GGA3 TSC2 TSC1 AKT1 ALS2 RAB3A RAB4A RAB7A OPTN RAB27A RAB8A AKT3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation EOMES FGFR1 SNAI1 TBXT SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2BC9 H2AZ2 H4C9 H2BC8 TBP TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 RRP8 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 H2BC11 H3C15 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters POLRMT TFAM MTERF1 TFB2M G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC RBBP4 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism ENO1 PGK1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal MGMT ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 FBXO5 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis FAR2 AWAT1 AWAT2 FAR1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases YY1 RUVBL1 H2AC20 TGFB1 H2AC1 TGFBR1 TGFBR2 KDM1B INO80C INO80B INO80E INO80D SMAD7 OGT PSMD8 PSMD6 H2AC17 H2AC12 PSMD7 PSMD2 PSMD3 NFRKB SENP8 PSMD1 HCFC1 ACTR5 PSMA5 PSMA6 PSMA3 ACTR8 PSMA4 PSMA1 PSMA2 UBA52 INO80 PSMD12 PSMD11 PSMD14 H2AC25 H2AC21 USP15 PSMD13 BAP1 PSMA7 PSMB6 FOXK2 PSMB7 UCHL1 FOXK1 PSMB4 PSMB5 ACTB UBB TFPT PSMB2 ACTL6A PSMB3 BARD1 UCHL3 UBC H2AC19 PSMB1 UCHL5 H2AC14 RPS27A ASXL1 NEDD8 ADRM1 H2AC8 ASXL2 H2AC6 PSMC5 H2AC7 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MBD5 PSMC2 MBD6 MCRS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling JUN IGF2BP1 MAPK6 MAPK4 KALRN DNAJB1 PRKACG PRKACA PRKACB CDC42 TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B HSPB1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 NCOA3 PSMA2 CDC14A UBA52 PSMD12 PSMD11 CDK1 CCND3 PSMD14 PSMD13 MAPKAPK5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDC42EP5 RPS27A CDC42EP3 CDC42EP2 FOXO1 ADRM1 PSMC5 PAK1 PAK3 PSMC6 RAC1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SEPTIN7 CDC14B FOXO3 PAK2 RAG2 RAG1 ETV4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFB105B DEFA1B DEFB1 DEFB104B DEFA6 DEFB109B DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 CCR6 DEFB133 DEFB132 PRSS3 DEFB108B DEFB108C PRSS2 CCR2 CD4 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC TP53 ARG2 SLC25A2 SIRT5 SLC25A15 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling TAS2R10 TAS2R13 TAS2R14 ADCY9 TAS2R16 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A ITPR1 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP TAS2R38 PDE11A PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 GPR183 PNOC GPR18 SSTR3 PTH1R GPR37 PDE10A GPR31 PTH2R GPHA2 GNAS GPR55 GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 TAS2R42 TAS2R45 CRHR1 PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW TRIO RASGRF2 ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 VAV3 HCAR1 ARHGEF11 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ ARHGEF15 PLEKHG5 HEBP1 ARHGEF17 GRM3 ARHGEF16 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A AGT GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP APP F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 RGSL1 GRPR CYSLTR1 CCL1 EDNRA CCL19 EDNRB PROK2 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 GPR17 ACKR3 NMB CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK ADORA1 HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HBEGF HRH2 HRH4 DRD1 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA PAK1 C3 ROCK1 ROCK2 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology NR5A1 CLTB YAP1 RELA WNT1 PERP ARPC1B ARPC1A ARPC4 ARPC5 MAMLD1 SLC2A2 ARPC2 ARPC3 IHH ACTR3 ACTR2 CNOT10 CNOT11 TCF3 YWHAE LDB1 LEP DPY30 CHD4 YWHAG CSF1 YWHAH EED MTA2 CARM1 DAG1 MMP2 MAML2 MAML1 TRIO ITSN1 MED1 RAC1 MED8 VAV3 ARHGEF11 MED4 ARHGEF12 MED6 MED7 PRKCQ MAML3 CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 NKX2-5 ARHGEF7 SOS2 NGEF KALRN RET RARG ASH2L TFAP2A TFAP2B TFAP2C UBE2I TNKS1BP1 SUMO1 TEAD1 TEAD2 TEAD4 HIF3A ELOB TCF12 ELOC RBX1 RARB AJUBA EPAS1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C POLR2A PLXNA3 POLR2B LCE1A POLR2C LCE1B POLR2D LIPJ POLR2E LIPN POLR2F LIPM POLR2G PRSS8 POLR2H LIPK POLR2I POLR2J KRT4 POLR2K KRT3 POLR2L KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ACTB LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL CSNK2A1 KRT33B KRTAP5-10 KRT33A CSNK2A2 KRTAP5-11 SPRR2A SPRR2B SPRR2D CSNK2B ST14 CDSN KRTAP16-1 KRTAP8-1 TP53 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 SOX17 KRT27 SRY KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 ABL1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 PLAC8 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A PLXNA4 MAP2K6 KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B CNOT4 KRTAP2-4 CDK8 KRTAP2-3 KRTAP2-2 CNOT6 KRTAP2-1 CNOT7 KRT13 KLK13 CDK5 CNOT1 KRT12 KLK14 CNOT2 CNOT3 KRT10 LCE3E KLK12 KRT19 CNOT8 KRT18 KRT17 CNOT9 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 WDR5 KRT6C KRT6B RPTN ZNF521 KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 KRT76 SMARCD1 KRT75 SMARCD2 KRT74 SMARCD3 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 RBBP4 KRTAP23-1 RBBP5 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PTPRC LELP1 RBBP7 KRTAP4-1 ACTG1 KRTAP12-1 KRTAP12-3 KRTAP12-2 SMARCE1 KRTAP4-9 KRTAP4-8 KRTAP12-4 KLF4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 PFN1 KRTAP11-1 CELA2A SOX2 PFN2 KRTAP5-9 KRTAP5-8 KRTAP5-7 NFASC KRTAP5-6 KRTAP5-5 KRTAP5-4 SOX9 KRTAP19-2 KRTAP19-1 RUNX3 SRGAP2 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DIAPH1 DSG4 RPS27 KRT82 KRT81 ITGB1 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 RHOC KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 RHOA KRTAP6-3 RHOB KRTAP21-1 EVL SRF CDK5R1 CDC42 COX7A1 CLASP1 CLASP2 KDM5B ARID1A ARID1B TYROBP IFNG ERBB2 HES1 POMC MARK3 MMP9 NCBP1 NRP2 NCBP2 TLN1 CNTN2 NRCAM ANK1 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 FYN POU3F3 WNT4 MCM5 MCM2 CLTC CYP51A1 SREBF2 CLTA AP2A1 VLDLR AP2A2 CDON AP2M1 PBX1 RAP1GAP PRKACG PRKACA PRKACB CCL3 ANGPTL4 LPL AP2S1 CXCL12 DICER1 AP2B1 TRPM1 PAX3 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP LAMA5 LAMA2 SH3KBP1 PXN LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NUMB UCP1 MTA1 PRDM16 ZNF423 ENAH MTA3 RPS4Y2 EBF2 RPS27L BMP7 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 GMPR RPS3 MYO10 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 PPP3CB RPS25 MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 WNT11 NOTCH1 CACNA1D GCK NFATC1 NANOG HSP90AB1 RDX NAB1 NAB2 DNM2 SIAH1 EGR2 EPRS1 ID1 EIF4E ID4 EIF4B ZFPM2 EPHB6 EFNB2 ARHGAP39 EFNB1 EFNB3 EPHB2 EPHB1 ARHGAP35 EPHB4 EPHB3 ITGA10 FOXH1 ACVR1B WNT3A ACVR2B GIT1 ACVR2A DRAP1 ACVR1C DSG2 EPHA2 PAK1 ABL2 PAK2 PAK4 POU5F1 TGFB1 CNTN1 FOXC2 FOXC1 SIX1 HOXD11 NPNT HOXC11 HIRA PAX2 HOXA11 GREM1 SALL1 SIX2 DSCAM DCC DSCAML1 NTN1 STX1B TNFSF11 SRGAP3 SRGAP1 JUP FGFR1 WASL IAPP PAK6 PAK3 PAK5 MYO9B TPST2 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 SERPINE1 RPL4 RPL5 RPL30 RPL3 ITGA2 RPL32 RPL31 RPLP1 ITGA8 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 CTCF RPLP2 FABP4 HOXA3 RPL35 COL9A1 RPL38 HOXA1 PKNOX1 COL9A3 RPL37 PRL COL9A2 HOXA4 AGRN PIAS2 RPL39 RPL21 HOXB4 CHD3 RPL23 HOXB3 RPL22 HOXB2 HOXB1 RPL13A HOXD1 RPL9P9 HOXC4 RPL37A RPL24 MEIS1 RPL27 MAFB RPL26 HOXD4 HDAC2 DPF1 RPL29 HOXD3 RPL28 ZNF335 DPF2 RPL10 RPL12 DPF3 RPL11 RPL36A SUZ12 RPL14 PAXIP1 RPL13 RPL15 RPL18 RPL17 RPL19 PCGF2 RPL39L SS18L1 RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 CD36 NCOA2 SS18 NCOA6 NCOA3 TET3 SHH DHH ADIPOQ CREBBP EYA1 BCL2 NTN3 AREG CDH4 BNIP2 TNF CTNNA2 MYOG EBF1 WNT10B SPAG9 MEF2B NR2F2 MYOD1 ADIRF PAGR1 MYF6 SLC2A4 ZNF638 TCF4 BCL7A CEBPD CDH15 ZNF467 BCL7C MYF5 BCL7B FOXA1 KDM6A TGFA FOXO3 ABLIM1 ABLIM2 PTK2 ABLIM3 AKT3 JUN MED19 UHRF1 MED18 MED11 MED9 MED29 MED28 MED22 MED21 CDK19 MED13L ETF1 GSPT2 GSPT1 ASAH1 GSC MIXL1 UPF3A UPF2 UNC5A UNC5B CIDEA CAP2 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 MC4R DARS1 EEF1E1 MC3R KARS1 IARS1 PKP1 MC5R SDCBP DSP DSG1 DSG3 MAPK7 APH1A ZIC1 FOXD3 PSENEN NCSTN TFE3 APH1B MITF CLTCL1 PSEN2 TFEC ADAM10 ALX3 TBX3 PSEN1 DNM1 SDC2 STT3B GPC1 MAG PRDM14 CRIPTO SHC3 LIN28A ZIC3 ZSCAN10 DNM3 MAPK12 GATA3 LYN SIAH2 RPLP0 PITPNA CFL1 STAT4 IL12RB2 ACTL6A MSN PIK3CD KAT2B KAT2A MEF2A FGF8 RPS6KA3 SOX1 GBX2 RPS6KA5 RPS6KA2 OTX2 TBX6 RPS6KA1 POU3F1 YY1 ITGA1 LEFTY1 CRIPTO3 ONECUT3 DAND5 ONECUT1 CFC1 CER1 PDX1 NKX6-1 NODAL PTF1A PAX6 ISL1 PTGDS FOXO4 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD1 SMAD4 SMAD3 NEUROG3 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 USP33 SNAI2 FOXA2 NEUROD1 NKX2-2 PAX4 HNF1A MAFA RFX6 INSM1 FOXA3 FARP2 PLXND1 PKP4 PLXNA1 IRS2 PIK3CB PLXNB1 FGF2 NCK2 FGF4 NCK1 FGF7 MESP1 FGF9 AKT2 GATA6 TBXT GRB10 ATP6V1E1 TBX20 SMYD1 TBX1 EOMES HRAS ATP6V1G1 MYOCD HAND1 ATP6V0B ATP6V0E1 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 HNRNPU SPTBN1 ATP6V0D1 SOS1 ATP6V0C MAGOH ATP6V1A SHC1 PIK3R2 PIK3R1 INS NRAS ATP6V1H MAPK1 ATP6V1C1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 FGF10 UPF3B MAGOHB SNW1 SRC RNPS1 SHANK3 GRIN2B THRAP3 GRIN1 RND1 DLG1 DLG3 TBPL2 DLG4 MBP EMX2 FAM120B ADGRV1 PCDH19 DOCK1 WFDC2 MECOM MSX1 MPZ OSR1 PLK1 ADGRG6 ZIC2 HMGCR TBX21 SALL4 CCNB1 HOXA6 PAX8 PAX7 AMH GDF1 PRX NOG CTNNA1 DMRT1 NOTO PMP22 FOXF1 SOX10 BRCA1 ZEB2 CASC3 SNAI1 RANBP9 KAT5 GXYLT2 CDH2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP CEACAM1 ZEB1 DCT IRF4 SEM1 PXDN BIRC7 BCL2A1 TYRP1 MLANA USF1 MLPH RBM8A CXCR4 EDNRB KIF4B KIF4A CAP1 EDN1 EDN3 LEFTY2 PABPN1 PI3 CAPNS1 CAPN1 SCD5 ELOVL3 KIT BMP4 TCF7L2 CDKN1A ALCAM TCF7L1 SCN11A HDAC1 HOXA2 CDKN2A UNC5C LEF1 UNC5D TCF7 CDC25B SCN10A AGAP2 TBX2 FLRT3 HINT1 CCND1 CHL1 LYPLA2 SIN3A ZSWIM8 CDK2 MSI1 CTNNB1 COL6A2 MET PLXNC1 SEMA6A COL4A4 SEMA6D CEBPB SEMA7A COL6A1 GPR143 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 LHX4 COL6A3 LHX9 RBPJ CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB TNRC6C COL6A5 MOV10 NTN4 STX1A SEMA3E MEF2C AGO3 SEMA4A AGO4 NELL2 CDH1 RPS6KA4 SCN1B MYC AGO1 SCN1A AGO2 EPHA5 EPHA4 TNRC6A EPHA7 TNRC6B EPHA6 YWHAB EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 XPO1 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B AKT1 SCN3A PSMD1 PRNP SPTBN2 GATA4 ARTN CD24 SCN2A SCN2B PRKCA ROBO2 YWHAZ GFRA1 PSMA5 GFRA3 PPARGC1A PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 RGMA PPARGC1B PSMA1 GFRA4 RELN PSMA2 CD72 SCN9A PABPC1 NRTN DOK2 UBA52 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C EFNA5 PSMD13 EFNA4 SPTA1 EZH2 PSMA7 CACNA1S PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX MED16 PSMB2 SCN4A MED15 PSMB3 SCN4B MED17 SLIT1 SCN7A UBC MED12 PSMB1 SLIT3 MED14 PDLIM7 MED13 RPS27A HEY1 MED10 HSPA8 HEY2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 CACNA1H PSMC2 MYL12A MED27 SIRT1 CACNA1G MED26 CACNA1I EIF4G1 MED23 MED25 MED24 MED20 PPARG PPARA DRP2 FURIN PCSK6 ROCK1 ROCK2 UTRN MBD3 GATAD2B GATAD2A NCAN RPS6KA6 HSP90AA1 EGF EGFR PLCG1 CCND3 E2F1 TFDP1 TFDP2 CDK4 KMT2D H2AX CSF3R SPI1 GFI1 LIG1 H2AB1 DLX5 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 FOXO1 DOK1 MYB EP300 IL6R RASA1 H3-3B H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 BTG4 RUNX1 EIF4A2 H2BC12 H2BC13 KDM5A EIF4A1 H2BC14 TUT7 H2AJ TUT4 H2BC15 DUX4 TAL1 H2BC11 PABPN1L RARA TPRXL DUXA CEBPA KMT2A DUXB DIS3L2 CBFB CEBPE KDM6B GATA2 PRM2 H3C15 PRM1 RXRA STPG4 H2BC9 METTL23 H2AZ2 DPPA4 DPPA3 H4C9 H2BC8 DPPA2 H2BC5 ZFP36L2 H2BC3 LEUTX STAT3 PAIP1 NPM2 H2BC1 NFKB1 KDM4E DEK FLI1 TPRX1 AICDA KLF5 H2AC20 SRPK1 H1-8 TPRX2 HDAC3 ZSCAN4 TBL1X PCK1 NCOA1 NCOR2 NCOR1 HAND2 TBL1XR1 SLIT2 PLIN1 ROBO1 SEMA5A AKAP5 TBX5 CACNG8 CACNG2 CACNG3 CACNG4 TRIM33 SMARCB1 CCNC SMARCC1 SMARCC2 HELZ2 CHD9 ST8SIA4 TFEB SH3GL2 WWTR1 YES1 TGS1 MEF2D SMARCA2 SMARCA4 ST8SIA2 HNF4G DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 MAN1B1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR SOS1 HBEGF SHC1 ARHGEF7 PIK3R1 NRAS STAM2 ADAM10 ADAM12 PTPRK EPS15L1 EPN1 PTPN11 SPRY1 PTPN3 CDC42 FAM83B ADAM17 SRC LRIG1 SH3KBP1 PXN EGF CBL EGFR UBA52 PLCG1 STAM CSK HGS PTPN12 UBB PAG1 UBC RPS27A FAM83D SH3GL3 AREG FAM83A EPS15 SH3GL2 SH3GL1 AAMP SPRY2 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV GYG2 GBE1 GYS2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication ORC4 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 CCNB1 RB1 CDK1 PPP2R3B E2F1 MCM8 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B ORC5 POLA2 PPP2R1A NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway RXRA NR5A1 NR2C2 PPARD NR2C1 NR2C2AP RXRG NR2F1 NR0B2 NR2F6 NR1D2 RXRB NR1D1 ESRRA RARG ESRRB ESRRG NR1H2 NCOR2 NCOR1 ESR1 VDR ESR2 HNF4A MED1 NR4A2 NR4A1 RORC THRB RORA THRA RORB NRBP1 HNF4G NR2E1 RARB RARA PGR PPARG AR PPARA RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME SLC29A1 ADK SLC29A3 NME1 NT5C2 SLC28A3 NME2 PNP ITPA ADA SLC28A2 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PLD6 PLD2 PLD1 PLD3 PGS1 CDS2 PTPMT1 PLD4 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle FAM169A ADD3 AKAP12 SNAP23 VANGL1 ARHGAP1 ARHGAP32 SLC4A7 ARHGAP39 PIK3R2 ARHGAP5 PIK3R1 RHOF ESYT1 SYDE1 BAIAP2L1 ACTN1 POTEE LMNB1 TMPO BASP1 ACTB TOR1AIP1 ARHGAP12 DEPDC1B CAPZB VAMP3 RAB7A STEAP3 DIAPH2 ARHGAP21 SOWAHC FARP1 MYO9B SRGAP2 MTMR1 BAIAP2L2 SENP1 DIAPH1 DIAPH3 CAV1 MCAM DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology ASH2L NCOR2 NCOR1 TBL1XR1 HDAC1 HDAC3 CAMK4 GPS2 SIN3A RBBP5 PRKACA DPY30 TBL1X WDR5 CALM1 KMT2D IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly UQCRFS1 BCS1L UQCRH LETM1 TTC19 UQCRHL FXN LYRM4 HSCB LYRM7 UQCRC1 UQCRC2 UQCC3 UQCC2 UQCC1 CYC1 UQCC6 UQCC5 UQCR11 UQCR10 UQCRQ HSPA9 UQCRB MT-CYB RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 RRN3 CBX3 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 MBD4 MPG SMUG1 OGG1 NTHL1 APEX1 TDG REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 HEYL SPCS3 SPCS2 SPCS1 ANGPTL4 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRDM8 CTNND1 UBA52 BHLHE22 CDH8 PSMD12 ZC3H12A PSMD11 CTNNA1 PSMD14 CDH24 HOXC8 PSMD13 FOXF1 CSNK2A3 ADAM33 SOX10 EZH2 PCSK7 PSMA7 ADAM19 ILF3 PSMB6 MPHOSPH8 ZEB2 CDH11 PSMB7 SNAI1 CDH19 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity NR3C1 ESRRA STAT1 NKX3-2 MSX2 ESR1 SMURF1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B PSMA5 STUB1 PSMA6 PPARGC1A PSMA3 PSMA4 PSMA1 PPARGC1B PSMA2 UBA52 PSMD12 PSMD11 PSMD14 WWP1 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DLX5 PSMB1 DLX6 RPS27A HIVEP3 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TWIST1 CBFB CUL1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT GPAA1 PLAUR PIGK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 TPMT MTR AS3MT MAT1A NNMT MTRR COMT CYP1A2 MAT2B HEMK2 MAT2A GSTO1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle APBA1 SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 CASK LIN7A LIN7C LIN7B TSPOAP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L POLRMT GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB AJUBA ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ACTB ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ANG AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 PSIP1 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 GTF3C1 ARID1A GTF3C2 ARID1B GTF3C3 RBL2 GTF3C4 RBL1 CRCP IFNG GTF3C5 ZNF197 GTF3C6 ZNF195 BRF1 NR2C2 POLR3GL NR2C1 POLR3A THBS1 POLR3B HSPD1 VEGFA POLR3C ERBB2 POLR3D HES1 GLS2 POLR3E ZNF189 POLR3F ZNF286A POLR3G ZNF184 POLR3H ZNF180 BDP1 OPRK1 GLS POLR3K ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 BCDIN3D CDK9 TCEA1 XPO5 DROSHA JAG1 MTERF1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ANGPTL4 LPL TSNAX PRKRA DICER1 TARBP2 TSN SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A TRPC3 MTA1 MTA3 ELAC2 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAN LBR CAV1 TGFB1 STEAP3 ITGA2B TDG ITGA5 SERPINE1 LIPE DGAT2 FABP4 CHD3 BMI1 LPIN1 SUMO2 MGLL RING1 RRP8 HDAC4 SAP130 HDAC2 DPF1 L3MBTL2 PDK4 DPF2 SATB2 KAT8 RNF2 DPF3 SAP30BP HCFC2 SUZ12 WDR82 CBX8 PAXIP1 PHC2 PEX11A PHC1 BAZ2A CBX5 KAT14 CBX4 PCGF2 SETDB1 SS18L1 CBX2 SMARCA5 PHC3 ZZZ3 GSK3B TADA2A ZNF816 EZH1 AXIN1 PHF1 SUV39H1 GPI SGF29 CD36 CDC73 JARID2 NCOA2 SS18 NCOA6 NCOA3 TET2 SKIC8 TET1 PPHLN1 BAZ1B PHF20L1 CTR9 RTF1 NR5A2 AEBP2 MTF2 TET3 LEO1 PLIN4 PAF1 PLIN2 MBD2 MYBBP1A MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 SP1 TASOR MBIP TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C BCL7B CAMK4 DNMT3B UBTF BDNF ZNF765 KDM6A TGFA DNMT3A FOS POLR1A FOXO3 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H AKT3 C19orf84 JUN ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP ERCC6 RRN3 CIDEC HCFC1 AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X MCRS1 YY1 USP7 NFIX SSB USP2 NFIA NFIB NFIC FOXO4 ATXN3 SUDS3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 TADA3 MDM2 MDM4 OGT PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 TFAM TFB2M CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP PLD6 MAPK1 CAVIN1 CSTF3 CSTF2 DDX4 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S SF3B1 CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 IPO8 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 MTREX RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 PIWIL2 TDRKH SNRPB SRSF9 PIWIL1 HENMT1 RBM8A ASZ1 MAEL MOV10L1 MYBL1 CPSF4 TDRD9 CHTOP TDRD6 TDRD1 TDRD12 CPSF1 FKBP6 ALYREF CPSF3 CPSF2 YBX1 RBM7 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SAP18 MORC2 GTF2A1 GTF2A2 GTF2B ACSL1 ELOVL5 GTF2E1 GTF2E2 KIT SCD TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 HSP90AA1 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 CEBPA KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L NCOA1 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 PLIN1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 PCBP4 TP53 CDKN1A ZNF385A MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation MT-ND6 COX5B MRPS10 COX5A MT-ND5 MT-ND2 MRPL32 MT-ND1 ECI1 PCCB SUCLG2 UQCRC2 PRKACA MRPS2 OGDH MT-ATP6 STAR FH SHMT2 TRIAP1 ATP5PF ATP5PD MRPL12 MDH2 ATP5F1C ATP5PO NDUFA13 SLC25A5 SLC25A6 HSD17B10 SPG7 AFG3L2 SMDT1 YME1L1 PMPCA NDUFV3 ATP5MG MICU2 NDUFV1 STARD7 IDH2 UQCRQ TFAM HADH OMA1 OPA1 ALDH1B1 ME2 IDH3A BDH1 OXCT1 HMGCS2 PRELID1 ACAT1 NDUFS1 CHCHD2 NDUFB6 COX4I1 IARS2 ARG2 MT-CO1 HTRA2 ECH1 ACOT2 NDUFA2 LONP1 TWNK SSBP1 LDHD MT-CO2 NDUFS3 CS HSPD1 ACO2 PDHB GLUD1 TIMM17A PDK1 PDHA1 TIMM22 HSPA9 OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 ALAS1 TIMM9 TIMM10 ATP5F1A ALDH2 ATP5F1B DBT DLD PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy SQSTM1 UBC MAP1LC3B PEX5 NBR1 RPS27A ATM EPAS1 UBA52 USP30 UBB RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 NFKB1 NFKBIA DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP62 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 CDK1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C CCT2 TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBB6 TUBB3 CCT7 TUBB1 TUBA3D TUBA3C CCT8 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PXN TESK1 PARVA PARVB ARHGEF6 RSU1 LIMS1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 HBEGF EGF ERBB2 EGFR NRAS NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi CHST8 B4GALT4 CGA FUT8 MAN2A1 MGAT5 MGAT2 FUCA1 MGAT3 MGAT4C CHST10 B4GALT6 B4GALT5 MAN2A2 ST3GAL4 MGAT4A LHB MGAT4B B4GALT1 ST8SIA6 FUT3 ST8SIA2 B4GALT2 B4GALT3 ST8SIA3 ST6GAL1 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism MTMR3 MTMR8 MTMR9 PIK3R4 RAB14 PIK3R2 MTMR6 PIK3R1 MTMR7 PITPNB INPP5E PIP5K1A PIP5K1B GDE1 SACM1L ARF3 MTMR14 VAC14 PI4KA PI4K2B MTMR10 MTMR2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A FIG4 PIP4P1 INPP4B INPP5J INPP5K PIKFYVE INPP5F PI4K2A PTEN MTMR1 PIP5K1C TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 GDPD1 RAB4A GDPD3 GDPD5 RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PNPLA7 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 PNPLA6 INPPL1 RUFY1 TPTE ENPP6 SBF1 PIK3CA PIK3R3 SBF2 TPTE2 PIK3C3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated APC MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle SLC25A11 MDH1 GOT1 MDH2 SLC25A12 SLC25A18 GOT2 SLC25A13 SLC25A22 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX9 MYD88 NFKB2 RELA NFKB1 IRF7 DHX36 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation RPS2 METTL21A KIN METTL22 HSPA8 EEF2KMT VCPKMT ETFBKMT EEF1AKMT2 EEF1AKMT1 EEF2 EEF1A1 CAMKMT VCP PRMT3 CALM1 ETFB TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 SLBP NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass PCNA UBA52 NPLOC4 POLH WDR48 USP10 RAD18 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL UBA7 RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2L6 TRIM25 UBE2B POLE2 POLE3 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KCNK12 KCNK15 FXYD4 FXYD3 FXYD2 DMPK FXYD1 FXYD7 FXYD6 MME ATP2B4 NPR1 RYR1 ATP2B3 NPR2 RYR2 ATP2B2 NPPC RYR3 ATP2B1 TRPC1 CORIN CES1 SLC8A3 CLIC2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 ATP1A4 CACNG6 ATP1A3 CACNG7 ATP1A2 TNNI3 ATP1A1 KCNIP1 KCNIP2 KCNIP4 KCNK6 RANGRF KCNK7 PLN KCNK1 KCNIP3 FKBP1B CACNA2D2 CACNB2 NKX2-5 SCN11A SCN10A CACNB1 SCN1B CAMK2B SCN1A CAMK2D CAMK2A KCNH2 TBX5 SCN3B SCN3A KCNK10 CACNG8 GATA4 CALM1 KCNK13 SCN2A CAMK2G KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 CACNG4 KCNJ2 KCNJ4 SCN9A KCNK9 SCN8A KCNJ12 CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A SCN4A KCNA5 SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 WWTR1 AHCYL1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors GPR31 FFAR4 FFAR1 FFAR3 FFAR2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PI4KB PIK3C2A PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2A ARF1 INPP5E TPTE SACM1L ARF3 OCRL TPTE2 PIK3C3 VAC14 PI4KA INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins KCNQ2 KCNQ3 SCN9A SCN11A SCN10A SCN8A SPTAN1 SPTA1 SCN5A SCN4A SCN4B SCN7A NRCAM SPTB ANK1 SCN1B SCN1A NFASC ANK2 ANK3 SPTBN4 SPTBN5 SCN3B SCN3A SPTBN2 SPTBN1 L1CAM SCN2A SCN2B CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 ERBIN HRAS SOS1 HSP90AA1 SHC1 ERBB2 CDC37 NRAS PTPN12 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN NCSTN APH1B PSEN2 PSEN1 YBX1 NOTCH3 APH1A ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage MAPDA GMPR2 ADK AMPD1 TK1 GMPR AMPD2 CDA AMPD3 DCK APRT DGUOK PNP HPRT1 ADA UCKL1 UCK2 UCK1 PUDP TK2 UPP2 UPP1 TYMP TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC26A2 SLC22A5 ABCB6 SLC24A2 ABCB4 SLC24A3 KCNJ11 SLC41A2 SEL1L SLC5A1 SLC41A1 SLC5A2 SLC30A10 ABCC9 ADCY9 SLC39A6 SLCO1B1 SLC39A5 SLCO1B3 ERLIN1 ADCY4 SLC39A8 ERLIN2 ADCY3 SLC39A7 CP ADCY2 SLC39A2 SLC6A5 ADCY1 SLC39A1 ADCY8 SLC39A3 SLC2A9 ADCY7 SLC26A4 SLC30A8 ADCY6 RNF185 SLC30A3 ADCY5 SLC26A3 SLC30A2 SLC31A1 SLC30A5 SLC40A1 SLC39A10 SLC2A1 ATP2A3 SLC30A1 SLC2A2 ATP2A2 SLC6A2 SLC39A14 ATP2A1 SLC6A3 SLC8B1 SLC8A1 SLC8A2 SLC22A12 HEPH ABCC2 SLC2A10 ABCC6 AVPR2 SLC24A4 SLC16A7 DERL3 SLC16A8 DERL1 EMB DERL2 SLC16A3 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 RHAG SLC24A5 APOB ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 GNAS RAB11A SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 NEDD4L ADD1 TUSC3 MAGT1 ZDHHC8 SLC46A1 SLC5A5 VDAC3 VDAC2 VDAC1 CFTR SLC32A1 SLC6A13 SLC6A1 ARF1 WWP1 CYB5R2 CYB5R4 CYB5RL SLCO1A2 NEDD8 ARL2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 VCP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SLCO4C1 HMOX2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 LETM1 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC6A7 ATP6V0B PLEKHA8 ATP6V0E1 ATP6V1G2 ATP6AP1 SLC6A11 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ABCG2 ATP6V0A2 SGK1 HBB ATP6V1H SLC6A4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 SLC17A7 ABCA3 ABCC3 CAMK2B ABCC1 CAMK2D ABCD3 CAMK2A SLC2A3 CALM1 CAMK2G ADD3 SLC4A7 PHB1 SLC25A10 CAND1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SEM1 SLC4A2 SLC4A3 SLC4A5 SLC5A8 SKP1 SLC5A9 TFR2 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A12 NIPA1 CUL1 NIPA2 CLTC SLCO4A1 SLC17A1 HDLBP RHBG PCSK9 CLTA DMTN SLCO2B1 AP2A1 SLC26A11 VLDLR LIPA SLC16A2 RHCG AP2A2 LIPC SLC26A1 CREB3L3 SLC15A1 IREB2 LIPG SLC14A1 CTNS LDLRAP1 SLC15A3 SLC14A2 AP2M1 SLC15A4 SLC4A10 CUBN CYBRD1 CYB5R1 PIP AMN SLC26A7 APOA2 ACO1 APOA1 SLC26A9 LSR SLC26A6 APOA4 PRKACG SLC25A1 APOA5 MB NPC1 RAF1 PRKACA SLC13A1 SOAT1 PRKACB SLC13A2 SOAT2 SLC13A3 NPC2 ANGPTL8 ATP7A SLC13A4 ANGPTL4 NGB SLCO1C1 LPA SLC47A2 CES3 TF CA1 SAR1B SLC47A1 SLC5A12 MTTP SLC5A10 LPL CA2 LMF2 SLC25A26 LMF1 LRRC8C CA4 LRRC8D APOF AP2S1 LRRC8A LRRC8B A2M LDLR SLC13A5 SLC11A1 GPIHBP1 LRRC8E GLTP FGF21 RSC1A1 MBTPS1 APOBR AHCYL2 APOC3 NIPAL4 NIPAL1 AP2B1 NIPAL2 TRPM1 NCEH1 ALB NIPAL3 TRPM2 P4HB AZGP1 TRPM7 SLC22A4 TRPM8 MBTPS2 SLC22A3 TRPM5 SLC22A6 TRPM6 SLC45A3 TRPM3 ANKH TRPM4 TRPC7 RAB11FIP2 ABCC4 TRPC5 SLC10A6 MCOLN3 MYO5B TRPC6 MRS2 AQP12A TRPA1 SLC22A15 AQP10 TRPC3 AQP8 SLC22A16 TRPC4 AQP9 SLC22A17 TRPC1 AQP6 SLC22A11 AQP7 SLC20A1 TRPV2 AQP4 SLC66A1 TRPV3 AQP5 FTMT TRPV1 MCOLN1 AQP2 ESYT3 MCOLN2 AQP3 ESYT2 AQP1 STEAP4 TRPC4AP MIP HFE TRPV6 MMGT1 TRPV4 AQP11 TRPV5 SLC2A6 SLC2A7 SLC2A8 PDZD11 GLRX3 CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 SLC35B3 LCN9 SLC35B2 STOML2 SLC27A1 MCUB LCN2 SLC35B4 SPG7 PHB2 SLC35D1 MAIP1 SLC35D2 LCN15 PARL AFG3L2 LCN12 SMDT1 SLC35A2 YME1L1 SLC35A3 PMPCB SLC33A1 SLC5A6 PMPCA ARL2BP MICU3 LCN1 MICU2 SLC29A4 MICU1 PRKAR1B SLC27A6 MCU PRKAR2B SLC28A2 PRKAR1A SLC29A1 PRKAR2A SLC2A13 SLC28A1 SLC29A3 SLC5A11 SLC5A3 SLC29A2 SLC28A3 SLC27A4 CYGB EIF2S2 EIF2S1 EIF2S3 PSMD8 PSMD6 HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 TFRC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 ABCA6 ABCD2 UBA52 AKAP1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 SLC6A9 PSMB7 SLC17A6 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 UBC ABCC5 PEX3 ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 SLC1A5 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 PEX19 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 FURIN BEST3 PCSK6 SLC9C2 BEST1 PCSK5 BEST4 ESYT1 SLN ATP11C SLC67A1 ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 STEAP3 ATP8B1 ATP4B ATP4A FXYD4 FXYD3 WNK1 FXYD2 WNK2 FXYD1 HBA2 WNK3 FXYD7 FXYD6 CUTC RYR1 RYR2 RYR3 UNC80 ATP7B CLIC2 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 SLC22A7 STOM SLC12A2 SLC12A4 RUNX1 SLC12A5 SLC12A7 FTH1 FTL SLC25A18 CETP SLC25A11 APOD APOE ABCA1 ABCG8 MYLIP SLC25A22 ABCG5 NR1H2 APOC4 NR1H3 APOC2 APOC1 ANGPTL3 ABCG1 SLC35C1 SLC24A1 SLC17A5 AVP SLC2A4 SLC35A1 SLC22A8 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling CREBBP RELA ICAM2 LYN ICAM3 RELB NFKB1 EP300 NRAS PAK1 PAK3 HRAS FYN PRKACG RAF1 PRKACA PRKACB PAK2 CD209 RPS6KA5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B RAD50 RAD51D BLM RAD51 MRE11 RAD51C BRCA1 BRCA2 RAD51AP1 WRN ATM BRIP1 DNA2 KAT5 EXO1 RBBP8 NBN MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DBT DLD VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 PCNA CDC6 HDAC1 DYRK1A CDK1 CDC25A E2F1 RBBP4 CDK2 TFDP1 CCNE2 TFDP2 LIN54 TOP2A LIN37 CCNE1 LIN9 MAX LIN52 MYC E2F4 E2F5 CCNA2 CCNA1 MYBL2 RBL2 RBL1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO6 FOXO3 FOXO1 RPS6KB2 AKT1 AKT2 FOXO4 NR4A1 AKT3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis RXRA SCD NR1H2 FASN NR1H3 RXRB NRIP1 ANGPTL3 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 HSP90B1 DDIT3 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25A PKMYT1 WEE1 CLSPN YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 CDC25C ABRAXAS1 TP53BP1 H2AX H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDC7 CDK2 CDC45 MDC1 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SFN YWHAZ PSMA5 PIAS4 PSMA6 PSMA3 PSMA4 BRCC3 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 BLM MRE11 PSMA7 BRCA1 BABAM1 PSMB6 BABAM2 PSMB7 WRN BRIP1 KAT5 PSMB4 EXO1 UIMC1 CHEK1 PSMB5 RBBP8 NBN UBB TOPBP1 PSMB2 ATRIP PSMB3 BARD1 UBC RFC5 RMI2 PSMB1 RFC3 GTSE1 RFC4 RPS27A RMI1 RFC2 TOP3A ADRM1 RPA1 HUS1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 RAD50 PSMC4 PSMC1 MCM7 PSMC2 MCM8 RPA3 RAD17 TP53 CCNB2 CCNA2 RAD1 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 ORC5 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription REST SRF NR3C1 KCNIP3 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling MET GAB1 PIK3R1 HGF PIK3CA G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint WEE1 CCNA2 CCNB2 CCNA1 CCNB1 CDK1 PKMYT1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells RELA MAP3K7 NFKB1 CHUK IKBKB CARD11 MALT1 NFKBIA PSMD8 PSMD6 PSMD7 PSMD2 REL NFKBIE PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PSMC5 PSMC6 PRKCB SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 RAB11FIP3 RAB8A ARF4 GBF1 PKD2 RAB3IP PKD1 RAB11A RHO CNGA2 CNGA4 EXOC8 EXOC7 CNGB1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG MTR MTRR INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 FZD2 APC FZD5 PPP2R5B WNT1 PPP2R5A FZD1 PPP2R5D PPP2R5C CSNK1G2 WNT3A LRP5 CTNNB1 LRP6 WNT8A WNT8B PPP2R1B PPP2R1A PPP2CA PPP2CB DVL1 DVL2 DVL3 AMER1 GSK3B CSNK1A1 CAV1 FRAT1 PPP2R5E AXIN1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT DHRS7B AGPS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins MUC13 B3GNT3 B3GNT5 B4GALT6 B4GALT5 GALNT12 ST6GALNAC2 C1GALT1C1 MUC12 ST6GAL1 MUC15 MUCL1 MUC3A MUC5AC MUC3B GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ST6GALNAC3 GALNT10 GALNT9 ST6GALNAC4 MUC1 GALNT8 MUC2 B3GNT9 QTGAL B3GNT8 B3GNT6 MUC7 GALNT1 CHST4 MUC4 GCNT1 MUC6 GCNT3 MUC16 GCNT4 GALNT3 GCNT7 MUC17 GALNT7 C1GALT1 GALNT6 MUC19 GALNT5 ST3GAL4 GALNT4 MUC5B A4GNT MUC20 GALNTL5 MUC21 GALNT2 GALNTL6 ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT4 B3GNT2 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL WDR83 SRC YWHAB HRAS IL17RD ARRB1 ARRB2 LAMTOR2 MAP2K1 MAP2K2 ITGB3 LAMTOR3 ITGA2B RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell DISP2 SCUBE2 SHH IHH DHH ADAM17 NOTUM GPC5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance KIFAP3 APOOL PRKACA KIF3B KIF3C ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 YWHAE CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 YWHAG RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 RAB11A ATAT1 TTC8 SOD2 CARM1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 MED1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 ACSS2 NR1D1 CHCHD3 PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 MEF2C PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 CCP110 MAPK12 TNPO1 HCFC1 PPARGC1A PPARGC1B CEP57 CETN2 CEP164 ACTR1A PCM1 NRF1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HSPA9 HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 ALAS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 HAUS7 CEP70 CEP72 CEP192 PCNT TUBA4A CEP76 CEP78 PLK4 ATP5F1A SIRT3 ATP5F1B ODF2 CEP152 NEDD1 ALMS1 MTX2 PPARA CEP41 CYCS CEP43 IFT172 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 CCT3 RPGRIP1L DMAC2L WDR35 IFT88 SMO TCP1 ESRRA KIF3A TTC21B WDR19 IFT122 MKS1 MT-ATP6 CCT8 CCT5 CCT4 CEP97 TUBB4B KIF17 TUBB4A ATP5PF ATP5PD ATP5PB ATP5F1C HSP90AA1 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 ATP5PO HDAC6 RHO CNGB1 PPP2R1A CPAP ATP5MC2 ATP5MC3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 TFAM TFB2M RXRA DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 SAMM50 PDE6D HDAC3 MTX1 MAPRE1 PAFAH1B1 TBL1X DYNC1I2 NCOA1 NCOR1 CLASP1 TBL1XR1 DYNC1H1 NDE1 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 CALM1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 NCOA2 NCOA6 CDK1 GLUD1 GLUD2 SIRT4 CRTC2 CRTC3 CRTC1 HELZ2 CREBBP CHD9 MICOS13 MICOS10 CHCHD6 MTERF1 RAB8A GABPA SIRT5 TGS1 PPRC1 MEF2D PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 TFB1M RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MRM3 RCC1L RPUSD4 NGRN DDX21 RPUSD3 NOP58 RPS4Y2 RPS27L RPS4Y1 TRMT10C PRORP RPS4X RPS15 ELAC2 RPS14 RPS17 HSD17B10 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction SOX17 POU5F1 FKBP6 SPAM1 LMNB1 CXCR4 PRDM1 PDPN FIGNL1 TEX12 TEX15 MSH4 MSH5 CD9 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B HVCN1 MND1 FIRRM REC8 SYCP3 STAG3 DMC1 PSMC3IP MLH3 CDK4 PRDM9 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L SPO11 H2BC21 SUN2 SUN1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 EOMES H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 NANOS3 CBFA2T2 H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 BMP4 H2BC1 POT1 TERF2IP H2AC20 NANOG HSPA2 CDK2 MLH1 B4GALT1 TFAP2C UBE2I CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 ZP3 ZP2 TET2 ZP4 BLM MRE11 BRCA1 BRCA2 RBBP8 NBN TOP3A RPA1 RPA2 RAD50 RAD51 RAD51C RPA3 ATM ATR DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN3 PAIP1 LSM5 LSM4 SKIC2 LSM3 LSM2 LSM7 LSM6 DDX6 LSM1 PATL1 CNOT4 EDC3 EDC4 CNOT6 DCP1B CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT11 DIS3 XRN1 SKIC8 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 CNOT6L EIF4A2 EIF4A1 DCP1A TUT7 TUT4 EIF4G1 HBS1L NT5C3B SKIC3 EIF4A3 DCPS PAN2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes IKBKB SQSTM1 UBC MYD88 RPS27A IRAK1 NGF TRAF6 UBA52 NGFR PRKCI UBB RIPK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription RBPJ MAML2 FCER2 MAML1 MAMLD1 HES1 MAML3 EP300 GZMB NOTCH2 HES5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPKAPK2 MAPK1 MAPK8 ATF1 MAPK3 ATF2 PPP2R1B PPP2R1A PPP2CA PPP2CB MEF2C MAPK9 MAPK14 MAPK11 MAPK10 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK HDAC1 H2AC20 ERCC6 MBD3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MTA2 RBBP4 MTA1 MYBBP1A MTA3 TTF1 RBBP7 ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP85 NUP62 NUP43 RCC1 RAN NDC1 SEC13 RANGAP1 UBE2I NUP155 NUP133 SUMO1 NUP93 NUP35 NUP54 NUP205 NUP37 POM121 NUP107 NUP188 KPNB1 TNPO1 NUP160 AHCTF1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere ACD LIG1 PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 BLM RPA3 WRN DNA2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 AKR1D1 CYP46A1 CYP27A1 CYP39A1 HSD3B7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 ANAPC4 NEK2 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 UBB UBC BUB3 RPS27A MAD2L1 ANAPC15 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation HPGDS GSTA3 GSTA1 GSTM4 AKR1A1 GSTT2 GSTT1 ESD GSTT2B GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 GSTZ1 GSTA5 GSTA4 GSTO1 CHAC1 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GSTA2 GGT3P GGT1 GCLM MGST3 MGST1 GSTP1 MGST2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance CLTC PCSK9 AP2S1 CLTA AP2A1 LDLR LIPA AP2A2 AP2B1 NCEH1 LDLRAP1 AP2M1 LSR APOB NPC1 SOAT1 SOAT2 NPC2 CES3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes ITGA5 PIEZO1 CACNA2D1 SPP1 CACNG7 GJA1 CACNA1H PANX1 HSPG2 CACNB2 AKT1 ITGB3 P2RX7 ITGB1 CACNB1 CACNB3 ITGAV SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants MAPK1 DUSP9 DUSP6 DUSP16 DUSP7 DUSP10 DUSP8 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis COQ9 COQ7 COQ6 COQ5 COQ2 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A STARD7 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN LAT2 SYK FYN BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs HPGD PTGS2 ALOX15 ALOX5 LTA4H PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis ADSS2 GART PAICS PFAS IMPDH1 ADSL IMPDH2 PPAT ATIC GMPS ADSS1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins JUN RELA IRAK1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A IL1B PELI1 MMP1 MMP2 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 MAPK8 SOCS1 IKBKB SQSTM1 MYD88 FCER2 CANX PTGS2 ALOX5 RBX1 SDC1 HIF1A SNAP25 GATA3 LYN INPP5D ARF1 RALA RPLP0 IL1RN PITPNA BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CSF1R MAP3K7 FPR1 MAP2K6 TCP1 BCL6 SMAD3 NFKBIA TAB1 TRAF2 TEC TRAF6 USP14 NOD1 ITGAM ITGB2 NOD2 IRS1 USP18 PPP2R1B IRS2 PPP2R1A PIK3CB FGF2 TNFRSF1B SOX2 TNIP2 PTPN13 INPPL1 TWIST1 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 SHC1 PPP2R5D PIK3R2 PIK3R1 RHOU ALOX15 MAPK1 BIRC5 CHUK MAPK3 PTPN11 CDC42 LIFR PPP2CA PPP2CB HNRNPF CASP1 OPRM1 IFNG MCL1 CD86 PTK2B CD80 VEGFA IL22 POMC CXCL1 NFKB2 JAK2 HNRNPA2B1 IL2RG MMP9 FBXW11 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B CCL3L3 CCR5 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 P4HB PRTN3 TIMP1 POU2F1 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FN1 BRWD1 BLNK BTRC S1PR1 JAK3 CD4 LCN2 STAT2 MMP3 IL23R IL13RA2 IL13RA1 IL4R IL23A CDKN1A FSCN1 NDN LIF NANOG IGHE OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 IL11 PIM1 IL19 IL16 IL17RE OSMR PSMD8 IL17RB PSMD6 HMOX1 IL31 IL17C PSMD7 IL11RA SOCS2 IL7 PSMD2 IL7R IFNL2 PSMD3 IFNL1 AKT1 IFNL3 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A UBE2V1 HSPA8 VAMP2 ICAM1 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 RAG2 RAG1 IL32 CASP3 IL34 IL1RL1 IL33 TGFB1 LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 RORC RORA TNFRSF1A HSP90AA1 CBL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 MAP2K1 HSP90B1 H3C15 STAT3 NFKB1 ITGAX FASLG IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs JOSD2 UBC RAD23A JOSD1 ATXN3L RPS27A VCP RAD23B PRKN UBA52 ATXN3 UBB SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT CLTC CLTB FZD7 WNT5B WNT5A ROR1 CLTA ROR2 AP2A1 PRICKLE1 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 PRKG2 AP2S1 ITPR1 ITPR2 AP2B1 ITPR3 WNT10A DPY30 WNT7B WNT7A BTRC PRKCB RAC1 WNT6 PPP3CA WNT2 PPP3CB GNAT2 PRKG1 PLCB3 WNT2B PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 WNT16 NFATC1 GNAO1 TCF7L2 TCF7L1 HDAC1 LEF1 PIP5K1B TCF7 CTNNB1 ASH2L TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 RSPO3 TNRC6A TNRC6B TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 VPS29 PSMD1 VPS35 WLS VPS26A TMED5 PRKCA TLE5 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SNX3 PSMA2 CSNK1G2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 SFRP1 PSMB5 CSNK1E SFRP2 WIF1 UBB PSMB2 SOST PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 MEN1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PRKCG GNG10 CHD8 GNG12 CAV1 CBY1 SOX3 GNG11 SOX17 GNG13 XIAP RNF146 SRY SOX6 GNB2 SOX7 SOX4 GNB1 BCL9L RUVBL1 CTNNBIP1 SOX13 MAP3K7 GNB4 USP8 PYGO1 GNB3 BCL9 PYGO2 GNB5 GNGT1 TLE4 TLE2 TLE1 GNGT2 CUL3 TNKS GNG3 SMURF2 GNG2 GNG5 GNG4 GNG7 GNG8 USP34 ARRB2 SCRIB VANGL2 WDR5 AXIN2 RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 LGR6 KLHL12 LGR5 WNT3 CCDC88C RSPO4 LGR4 DACT1 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B DAAM1 H2BC21 PFN1 EP300 PARD6A SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 H3C15 PPP2R5E FRAT2 H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 H2BC1 H2AC20 RHOA PPP2CA PPP2CB SMURF1 CAMK2A AMER1 CALM1 GSK3B CSNK1A1 AXIN1 APC PORCN CDC73 LEO1 KAT5 CTBP2 CTBP1 CREBBP TERT WNT10B WNT9B SEM1 SMARCA4 WNT4 TLE3 SKP1 CUL1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4 AGRN B3GALT6 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MBD3 GATAD2B GATAD2A CHD3 DPF1 HDAC2 DPF2 DPF3 CHD4 SS18L1 ARID1A ARID1B SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 SMARCC1 MTA1 SMARCC2 MTA3 RBBP7 ACTB SPOCD1 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 PIWIL4 H3-3B H3C8 H2AC8 DNMT3L H2AC6 BCL7A H2AC7 BCL7C H2BC17 BCL7B SMARCA2 H2BC12 SMARCA4 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 C19orf84 H3C15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 MBTPS1 HSP90B1 MBTPS2 DDIT3 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control VCP RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 TCF25 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 ZNF598 RPS27 RPS23 ANKZF1 ASCC2 KLHDC10 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling CRLF1 TYK2 CANX IL6ST JAK2 IL27RA EBI3 STAT3 JAK1 STAT1 IL27 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o DPM3 DPM1 DPM2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport SLC22A5 RSC1A1 SLC14A1 SLC14A2 SLC22A4 SLC67A1 SLC22A2 SLC22A3 SLC22A1 RUNX1 SLC22A15 SLC22A16 SLC47A2 SLC47A1 SLC25A26 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RELA NFKB1 BST2 NPM1 ITCH PCBP2 NLRP3 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 UBE2I MAVS TKFC YWHAB FKBP1A RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 YWHAQ PYCARD YWHAG YWHAH YWHAZ SFN PPIB TRAF3 TRAF6 UBA52 TLR7 IFIH1 RIPK3 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 TOMM70 UBB RPS17 RPS15A RPS16 RPS19 UBC SP1 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 BCL2L1 EP300 RPS13 RPS12 RPS9 RPS7 RPS8 PPIA IRAK2 RPS5 RPS6 PSMC6 RPSA RPS3A RUNX1 RPS26 EEF1A1 RPS25 RPS28 KPNA2 PDPK1 RPS29 RPS20 FAU RPS21 RPS24 PPIH RPS27 RPS23 PPIG CAV1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSME1 PSMB10 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMD9 PSMD4 PSMA5 PSMD5 PSMA6 PAAF1 PSMA3 PSMA4 PSME3 PSMA1 PSME4 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMD12 PSMG4 PSMD11 PSMG1 PSMG2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBC RPS27A CBL UBA52 MKNK1 SPRY2 MAPK1 MAPK3 BRAF PTPN11 UBB PPP2R1A BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors STAB2 APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 HSPH1 HYOU1 IGLV2-11 SCARF1 S100A9 IGLV1-40 APOB HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 HMGB1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 COL4A2 COL4A1 FTH1 PRDX1 SCGB3A2 MASP1 SPARC FTL V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 APOE V2-8 V1-20 CALR V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD36 LRP1 COL1A1 SSC5D COL1A2 STAB1 CD5L SAA1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CCL2 EDNRA CCL1 EDNRB CCL19 PROK2 CCR2 CCL17 AVPR2 PROK1 AVPR1A CCL16 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP NMS PDYN NMU AGTR2 FPR3 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 CCKAR PNOC SSTR3 EDN1 GPR37 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR MT-RNR2 INSL3 F2RL1 INSL5 PENK F2RL2 F2RL3 APLN GPR37L1 KEL PMCH NLN PPY MC1R GHSR MC4R F2R MC3R UTS2 GAL NTS MCHR2 NPB NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R NPY1R APLNR BDKRB2 BDKRB1 QRFPR XCL2 XCL1 PYY HEBP1 CCK GPER1 HCRTR2 HCRTR1 NPY5R KISS1 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 OPRD1 ACKR1 C5AR2 C5AR1 C5 AGT PF4 C3 FPR1 NPY CXCR1 CXCR2 OPRM1 SST OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling IL18RAP IL18R1 IL4 IL18BP IL13 IL18 IL37 ALOX5 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants HRAS NRAS KRAS ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins YWHAH SFN YWHAZ DYNLL1 DYNLL2 PPP3CC E2F1 BID TP63 PPP1R13B MAPK8 BCL2L11 TFDP1 TFDP2 BAD BBC3 BCL2 PMAIP1 AKT2 BMF YWHAB YWHAE TP73 TP53 AKT1 PPP3R1 TP53BP2 YWHAQ YWHAG AKT3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions PARD6G CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 PRKCI CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 PATJ CLDN18 CLDN17 CLDN16 PARD6A F11R CRB3 PARD6B PARD3 CLDN5 PALS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C S100A9 S100A8 YWHAE YWHAQ YWHAG YWHAH FLNA LIMK2 PRKCB RAC1 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 CTNNB1 CDH1 YWHAB MYL9 XPO1 CYFIP1 NCKAP1 PRKCD AR PRKCA NCF1 SFN YWHAZ NCF2 NCF4 CFTR BRK1 BTK CFL1 CYBB CYBA ACTB NOXO1 MEN1 MAPK14 MAPK11 PAK1 MYLK NCKAP1L WASF1 PAK2 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX3 ABL1 NOX1 ROCK1 ROCK2 WIPF1 WIPF2 CYFIP2 WIPF3 NUP107 LIN7B NUP160 CIT IQGAP1 NUP85 PKN3 IQGAP2 IQGAP3 NUP43 RANBP2 SEC13 GOPC CDC25C PKN2 NUP133 PKN1 CDKN1B NUP37 ERCC6L WASL ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 MRTFA KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 DAAM1 H2BC21 ZW10 NCK1 PFN1 WAS MAD1L1 PFN2 H3-3B CDCA8 H3C8 PRKCZ H2AC8 PMF1 SKA1 H2AC6 SKA2 PAK3 H2AC7 DSN1 H2BC17 WASF3 DVL1 DVL2 H2BC12 DVL3 H2BC13 SRGAP2 H2BC14 SCAI H2AJ RCC2 KTN1 PDPK1 H2BC15 NDC80 ZWINT H2BC11 DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PIK3C3 H3C15 PPP2R5E NUF2 KIF14 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 H2BC1 RHOC RANGAP1 RHOD H2AC20 CKAP5 DYNLL2 RHOQ RHOA RHOB KIF2A KDM1A MAPK1 INCENP PIN1 BIRC5 EVL KIF2C RTKN KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 MAPK3 CENPA AURKB NSL1 CENPC CDC42 PPP2CA RHPN1 PPP2CB RHPN2 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ DLG4 SPC24 CALM1 SPC25 MAD2L1 CENPS PLK1 NCOA2 CTNNA1 PPP1CB PPP1R12A PTK2 CLIP1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation MAPK1 SOS1 SHC1 INS MAPK3 GRB10 IRS1 INSR IRS2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) RPS6KA1 JUN H2BC9 H2AZ2 CXCL8 H4C9 VENTX H2BC8 RELA H2BC5 H2BC3 MAPK7 STAT3 H2BC1 CDKN1A NFKB1 CDKN2A H2AC20 MAPK1 CDK2 CEBPB MAPK3 EHMT2 EHMT1 IL6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDKN2D ANAPC11 CDKN2C CDC23 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 CDKN1B ANAPC4 ANAPC5 FZR1 ANAPC1 ANAPC2 IGFBP7 CDK6 IL1A CDK4 H2AX UBB H2AB1 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS CCNA2 CCNA1 H2BC11 RPS6KA3 RPS6KA2 H3C15 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription HOXC8 HEYL FOXF1 SP1 ILF3 ZEB2 SNAI1 PRDM8 BHLHE22 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses CGAS TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC TRIM21 STAT6 MRE11 NLRC3 IFI16 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling ADAR ARIH1 PPP2R5A STAT3 NPM1 HSPA1L DHX9 HSPA2 CHUK SPHK1 EIF2AK2 ISG15 MAP2K6 STAT1 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB FANCC PPP2CA PPP2CB PRKRA TARBP2 UBE2I MAVS SNCA SUMO1 DUS2 TRIM25 CENPS CENPX ILF2 CDK1 ILF3 IKBKG PPP2R1B PPP2R1A PTPN2 DNAJC3 NCK1 FAAP100 FAAP24 HSPA8 FAAP20 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A TP53 UBE2L6 HERC5 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF10 FGF2 EGF FGF4 FGF7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LMF1 GPIHBP1 FGF21 MBTPS1 FURIN PCSK6 LIPC CREB3L3 APOC2 PCSK5 ANGPTL3 MBTPS2 APOA4 APOA5 ANGPTL8 ANGPTL4 LPL LMF2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response XIAP CARD8 CYCS UACA BAK1 CDKN2A GSDMD GSDME BAX MAPK1 C1QBP AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance PCNA RUVBL1 NPM1 WRAP53 PIF1 GAR1 CTC1 CENPW CENPX RUVBL2 OIP5 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 RBBP4 RTEL1 CHTF8 DAXX ATRX RSF1 RBBP7 PRIM2 MIS18A PRIM1 POLA1 H2AX DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 KNL1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC1 H3-3B STN1 TEN1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 CDK2 ITGB3BP CENPA CENPC FEN1 CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L BLM WRN HJURP RFC5 RFC3 RFC4 TERT RFC2 RPA1 MIS18BP1 RPA2 RPA3 CCNA2 CCNA1 DNA2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors PIAS4 PIAS3 TFAP2B SUMO3 SUMO2 TFAP2C UBE2I PIAS1 CDKN2A SUMO1 MDM2 FOXL2 MITF HIC1 SP3 MTA1 TP53BP1 TP53 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3 CRIPTO DPPA4 ZIC3 EPHA1 FGF2 SALL4 STAT3 SOX2 POU5F1 NANOG SALL1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B2 SRD5A3 HSD3B1 CGA LHB HSD17B3 HSD17B12 SRD5A2 CYP17A1 SRD5A1 POMC SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 RXRA APH1A TGFB1 GIPC1 TGFBR1 PSENEN TGFBR2 NCSTN APH1B PSEN2 PSEN1 ACVR2A INHBA INHA TGFB2 SP1 TIMP2 FGF2 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B TIMP1 MYF5 TCF3 HELLS TCF12 KLF16 ARRB1 ARRB2 RARA MMP14 MMP16 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression TP53 PRDM1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 GP9 ADAMTS13 VWF GP1BA GP1BB AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation NTRK1 PIK3CB PIK3R2 PIK3R1 NGF PIK3CA IRS1 RHOA IRS2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 H2BC1 LIG4 MDC1 PAXIP1 RNF168 NSD2 PIAS4 BRCC3 PRKDC MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN BARD1 H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2BC15 DCLRE1C RIF1 H2BC11 ATM POLL NHEJ1 POLM TDP2 TDP1 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy CETN1 PARK7 UBC DYNC1LI1 CFTR RPS27A DYNC1I1 HSP90AA1 DYNC1LI2 DYNLL1 UBE2V1 PRKN DYNC1H1 UBA52 ARL13B DYNLL2 HDAC6 PCNT HSF1 VCP IFT88 DYNC1I2 UBE2N UBB RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter CRCP TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 POLR1C POLR1D INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease RELA ARPC1B NPM1 ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 NR3C1 IRAK1 NCKIPSD IL6 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 VAV3 MED4 MED6 MED7 UBE2N VAV1 VAV2 MAPKAP1 NEDD4L C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 V1-11 PTGES3 V1-16 V1-13 MAPK8 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB V2-8 V1-20 V1-9 TAF7L V5-4 FEN1 V1-7 V5-1 V1-5 UBE2I V1-3 V5-6 SUMO1 C1QA C1S UBE2D2 ELOB V4-6 ELOC V4-2 RBX1 V4-1 VHL RNMT CCNH POLR2A ISCU SNAP25 POLR2B POLR2C POLR2D SYT1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 GNG10 GNG12 GNG11 GNG13 KPNA7 KPNA4 GNB2 KPNA5 GNB1 GBP1 KPNA3 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 CDK8 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 ACTG1 PPP1CC TXNRD1 PML DYNC1LI1 DYNC1LI2 FCGR2A DVL1 DVL2 DVL3 TXN RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 HBB CD33 CHUK TJP1 DYNC1I2 CDC42 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X NFKB2 JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 PRKACG IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 FCGR3A BRD4 RPS18 CRBN RPS3 MYH2 MYO10 IGLC7 RPS2 IGHV3-53 MYO1C RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 PRKAR1B RPS5 PRKAR2B RPS6 PRKAR1A RPSA PRKAR2A RPS3A PRKX RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HBEGF HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E RNF213 ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A GBP2 GBP4 TLR6 IKBKE IRF7 CYFIP1 NCKAP1 BRK1 RAN NEK2 PDIA3 TUBB CYBA VPS36 VPS25 CBX1 SNF8 CHMP1A RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L SUGT1 WASF1 PAK2 IGF1R WASF2 CALM3 CALM2 CAV1 BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A WIPF1 WIPF2 FXYD4 WIPF3 FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 FCGR1A SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C DUSP16 TMPRSS2 WASL SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 NRP1 MAP2K1 MAP2K2 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 ENO1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 PGK1 ARID4B SAP30 MAP2K4 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD MAP2K7 TAB3 TAB2 NFKBIB ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 ARIH1 IFNA13 IFNA14 ADCY9 IFNA16 SAP30L IFNA17 ADCY4 BAG2 MED9 ADCY3 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 FGR GGT5 PATJ VPS39 VPS18 LARP1 ITPR1 VPS11 ITPR2 GGT1 VPS16 ITPR3 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 NOS2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 P2RX7 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 P2RX4 PARP8 TUFM GEMIN4 GEMIN5 CRK GEMIN6 GEMIN7 GNAS GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 GSDMD DNAJC10 NMT1 VPS33B RIPK3 CORO1A IL18 HGS IL1A RAB5A KPNB1 IL1B TLR4 BCAP31 FNTA CHMP4C UPK1A EPCAM CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 STAM RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IL10 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 AHCYL1 TAF9B KPNA2 MAP3K7 H2AC1 STAM2 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 GNAZ CD163 SMAD4 RHBDF2 ADORA2B SMAD3 ADAM17 NFKBIA SCAP MAVS CYFIP2 TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 WASF3 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 DPEP2 CRNKL1 CDC40 DPEP1 ATP6V1H MAPK1 DHX9 CSTF3 CSTF2 ELMO2 MAPK3 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D SRC RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 CALM1 DOCK2 CAMK2G HNRNPH2 DOCK1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CTSG CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 LTF TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 CD9 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 MET ACOT2 STX1A CDH1 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 C3 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B TRIM27 HSP90AA1 CBL EGFR PLCG1 RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 SFPQ IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 GNAI3 GNAI1 GNAI2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 SH3GL3 EPS15 SH3GL2 SH3GL1 ST3GAL1 ST3GAL2 ST3GAL3 YES1 EEF2 CTSL SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses RELA PPIB NFKB1 BST2 TRAF3 TRAF6 UBA52 ITCH TLR7 IFIH1 RIPK3 KPNB1 PCBP2 UBB TOMM70 NLRP3 UBC RPS27A TBK1 IRF3 NFKBIA STING1 MAVS IRAK2 PPIA TKFC FKBP1A RUNX1 RIGI RCAN3 KPNA2 NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 PPIH PPIG PYCARD PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A APOL1 COPS3 COPS6 HMGB1 COPS5 COPS8 PRDX1 CHMP3 CHMP6 CHMP7 PLA2G6 V2-11 V3-4 DCTN6 V3-3 DCTN5 V2-17 DCTN1 GJC1 V3-2 DCTN4 GJC2 V2-15 GJA3 V2-19 V1-11 GJA10 GJA5 CLTCL1 GJA4 V1-16 MAN2A1 GJA9 V1-13 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 V2-8 GJB5 V1-20 GJB7 CHM TMED2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 CD59 DNM3 CD55 V4-6 V4-2 V4-1 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 CD163 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 HP STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 HBB TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 APOA1 COG8 COG7 COG6 COG5 COG4 IGHV3-23 COG3 RAB27B COG2 COG1 IGLV RINT1 RAB30 IGLV2-8 RAB36 IGKV1-16 TF KIF16B IGKV1-17 SAR1B KDELR2 IGKV1-12 KIF20B IGHV3-7 COPB2 IGHV3-9 COPA IGHV3-30 TMED10 ARL1 IGHV3-33 AP2S1 KIF3B AGTR1 IGKV1D-39 MAN2A2 VTI1A LDLR IGKV1D-33 SERPINA1 KIF3C RAB6B IGKV2D-28 RAB39A IGKV4-1 KIF18B IGHV7-81 KIF4B AP2B1 ALPP IGKV2D-30 KIF4A IGHV4-59 ALB COPE IGHV1-69 KIF12 KIF11 USE1 IGLV2-11 BICD1 S100A9 RABEPK IGLV1-40 BICD2 IGLV1-47 KIF15 KIF19 IGLV6-57 IGLV2-14 MAN1A2 F5 IGLV1-44 KIF13B F8 TMED3 KIF1C IGKV3-15 KIF1B IGKV3-11 IGKV2D-40 MAN1A1 IGHV3-11 KIF1A IGHV3-13 TMED7 TMED9 IGLV7-43 IGKV1D-16 NAA30 IGKV1D-12 KIF25 COPZ2 IGLV1-51 IGLV2-23 KIF22 STX4 KIF6 BET1L IGKV3-20 KIF27 COPZ1 SH3KBP1 SLC2A8 IGHV4-34 RAB33B IGHV1-2 KIF9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 CD3G IGHV NAA35 CD3D IGKV2-29 NAA38 VAMP4 IGKV2-28 PAFAH1B3 IGLC3 ARF5 NAPA NAPB IGLC1 NBAS CHRM2 IGLC2 TMF1 STX16 IGKV3D-20 STX18 GOSR1 GOLGA2 NAPG STX10 IGKV2-30 IGLV3-19 CYTH3 ARFRP1 IGHV2-70 IGHV2-5 CYTH2 IGLV3-1 CYTH4 IGHV3-48 CUX1 IGLV3-25 VPS51 CD4 IGLV3-27 VPS53 VPS52 IGKC IGKV1-39 MAN1C1 IGLV3-21 BNIP1 STX6 IGKV1-33 VPS54 CYTH1 RIC1 IGLC7 IGHV3-53 MYO1C GALNT2 ARCN1 IGKV5-2 RGP1 KIF26A IGLC6 IGKV1-5 KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB CALR PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A COL1A1 COL1A2 SSC5D STAB1 CD5L SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 STAB2 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 HSPH1 SNX2 FNBP1L HYOU1 SNX9 SNX5 SCARF1 TBC1D8B PUM1 HBA2 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 HSP90AA1 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 COLEC12 KIF20A MSR1 TMEM115 CNIH2 COLEC11 CNIH3 SCARA5 HSP90B1 MCFD2 MARCO MIA2 COL3A1 PPP6R1 COL4A2 COL4A1 TRAPPC6A FTH1 TRAPPC6B SCGB3A2 SEC22A SEC22C MASP1 FTL SPARC STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF APOE PLIN3 GGA2 GGA1 GGA3 CD36 LRP1 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 SAA1 TGFA HPR HPX IGHA1 IGHA2 EREG AMBP BTC JCHAIN EPGN AKT3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDC7 CDK2 CDC45 PRIM2 PRIM1 POLA1 POLA2 POLE MCM10 RPA1 DBF4 RPA2 RPA4 MCM7 MCM8 POLE4 GMNN RPA3 MCM3 MCM4 POLE2 MCM5 POLE3 MCM6 MCM2 ORC5 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle TRAK1 TRAK2 RHOT1 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SLBP LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants LRP5 KREMEN1 KREMEN2 DKK1 DKK2 DKK4 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade SERPING1 CFD C3 GZMM CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 CD81 C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S FCN1 C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC FCN2 FCN3 CRP COLEC10 PROS1 F2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription SGK1 NAB1 NAB2 LYL1 REST F3 ATF1 DNM2 SRF ARC TRIB1 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 SH3GL3 ID1 CDK5 VGF ID4 FOSB EP300 ID3 JUNB CDK5R2 MEF2D TCF12 FOS CHD4 ELK1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding OGG1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency NAGS TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway CREBBP TBK1 IRF3 TRAF3 EP300 MAVS RNF135 RIGI IFNB1 IFIH1 TRIM25 IKBKE TRIM4 IRF7 SIKE1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCD4 TCN2 CD320 LRP2 ABCC1 LDLRAP1 TCN1 LMBRD1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres ACD TINF2 PCNA TERF1 TERF2 RUVBL1 POT1 TERF2IP WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 BLM RTEL1 CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 RFC5 POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 CHTF18 RFC2 TERT RFC1 STN1 RPA1 TEN1 RPA2 RPA3 CCNA2 CCNA1 DNA2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GUSB SGSH GNS ARSB GALNS HGSNAT NAGLU HYAL1 GLB1 IDS IDUA DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm YAP1 SMAD2 SMAD3 TBXT LEF1 TCF7 TEAD2 NOTO TEAD4 FOXH1 FOXA1 CTNNB1 SHH FOXA2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D TBCE TUBA3C TUBA8 TUBA1C TUBA4B TUBA1B TUBA4A TUBA1A TUBB4B TUBB4A TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SLC24A2 SLC24A3 SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SRI CALM1 SLC24A5 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling XIAP RELA MAP3K7 NGF USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 NSMAF SMPD3 SMPD2 RIPK1 TBK1 IRAK1 ADAM17 NFKBIA TAB1 TAX1BP1 ARHGDIA YWHAE TNFAIP3 RNF31 SPATA2 TNFRSF1A OTUD1 UBE2L3 TRAF2 TNFSF10 TRAF6 PRDM4 FADD BIRC2 BEX3 BIRC3 CFLAR PRKCI USP21 TRIO RASGRF2 OTULIN ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 TRADD ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 CASP8 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN RACK1 TRAF1 ARHGEF3 ARHGEF4 ULK1 TNFRSF10B ARHGEF1 TNFRSF10A ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF TNFRSF10D ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 RBCK1 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 CHUK ECT2 ITGB3BP FAS ARHGEF33 FASLG NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 SHARPIN LINGO1 MAG OMG RTN4 HDAC2 UBE2D2 UBE2D3 IKBKE CASP2 STUB1 BAG4 UBE2D1 MAPKAPK2 UBA52 CYLD OTUD7B IKBKG UBB RIPK2 UBC RPS27A CASP10 TNF OPTN TAB3 TAB2 CASP3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 TASL HMGB1 CASP8 IRF5 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 TLR8 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling IL23R STAT3 IL23A RAP1B LMNB1 TCP1 CA1 STAT1 CDC42 CRLF1 CANX IL6ST IL27RA EBI3 HNRNPF IL27 P4HB SNRPA1 IFNG ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 JAK2 STAT4 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA PAK2 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP CTNNB1 IRF3 EP300 LRRFIP1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense SFN GBP1 CASP1 PIM1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation NR5A1 SRY SOX9 PTGDS DHH FGF9 WT1 AMH GATA4 DMRT1 ZFPM2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex PCNA MAX LIN52 CDC6 MYC HDAC1 E2F4 CDC25A E2F5 E2F1 RBBP4 TFDP1 TFDP2 LIN54 TOP2A LIN37 LIN9 RBL2 RBL1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB4 FGF2 THBS1 ITGB5 ITGA6 TNC TGFB1 VTN ACTN1 ITGA2 CASK SDC1 SDC4 ITGB3 ITGB1 SDC2 TRAPPC4 SDC3 ITGAV SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF BAIAP2 ABI2 ABI1 RICTOR ROCK1 ROCK2 PRKACG PRKACA PRKACB SPHK1 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 NOS3 PRR5 CRK PXN HSP90AA1 JUP PLCG1 SHB SH2D2A PIK3CB AXL NCK2 NCK1 RASA1 AKT2 PRKCZ PAK3 PRKCB RAC1 HRAS WASF3 BCAR1 VAV3 PDPK1 NRP1 PIK3CA ITGB3 VAV1 VAV2 TRIB3 MAPKAP1 ITGAV PIK3R2 PIK3R1 NRAS THEM4 RHOA CTNNB1 ELMO2 CDC42 MLST8 MTOR SHC2 HSPB1 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA FLT1 FLT4 NCF2 KDR NCF4 VEGFB PTK2B VEGFC VEGFD PGF BRK1 VEGFA MAPKAPK2 CTNND1 CTNNA1 CYBB CYBA MAPKAPK3 NRP2 CDH5 AAMP MAPK14 MAPK11 PAK1 AHCYL1 FYN NCKAP1L WASF1 PAK2 PTK2 WASF2 CAV1 AKT3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ARIH1 FURIN NPM1 OAS2 EIF2AK2 SPHK1 ISG15 MAP2K6 STAT1 FANCC PRKRA IRF3 TARBP2 MAVS RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 CENPX NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 FLNA PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 KPNB1 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B EIF4E2 FNTA FLNB MX2 DNAJC3 MX1 EIF4G3 EIF4G2 NCK1 EIF4A2 EIF4A1 UBE2L6 EIF4A3 HERC5 UBE2N ADAR PPP2R5A STAT3 HSPA1L DHX9 PIN1 HSPA2 CHUK MAPK3 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB PPP2CA PPP2CB EIF4E UBE2I SNCA GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 CASP1 NUP214 CENPS SFN ABCE1 UBE2E1 UBA52 CDK1 ILF3 JAK1 ACTB IKBKG UBB UBC PTPN2 RPS27A FAAP100 HSPA8 FAAP24 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation FGFR4 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B CHMP4A GABARAP CHMP2B CHMP2A UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A CHMP3 ATG12 ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B DYNLL2 TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 WIPI1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC25A10 SLC5A8 SLC5A12 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions COL4A2 COL18A1 COL4A1 ITGA5 ITGA3 ITGA9 COL16A1 ITGA1 ITGB8 COL13A1 ITGB5 ITGA6 JAM2 TNC JAM3 COMP IBSP SPP1 FBN1 ITGAX ITGB6 ITGA2 COL23A1 HSPG2 ITGA8 COL4A4 ITGA7 ITGAL COL4A3 VCAM1 LUM CD47 ITGA11 ITGA4 CD44 COL9A1 ITGAE COL9A3 PECAM1 COL9A2 AGRN ITGB7 CDH1 ITGAD KDR THBS1 FN1 VTN ITGA10 FGB FGA ITGAM ITGB2 FGG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 F11R BSG ITGB3 ITGB1 ITGA2B ITGAV PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening CACNB4 CACNG2 CACNA2D2 CACNG4 CACNA1B CACNA1A CACNA1E CACNB2 CACNA2D1 CACNA2D3 CACNB1 CACNB3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation FCGR1BP SEC61A2 SEC61A1 TIRAP TAPBP SEC22B B2M HLA-A TLR1 S100A9 PSMB10 S100A8 TLR2 FCGR1A STX4 CD14 TLR4 LY96 HMGB1 ITGAV HLA-H ITGB5 HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 CHUK LNPEP IKBKB MYD88 CD207 CALR CTSS MRC2 MRC1 VAMP8 PSMD8 PSMD6 TLR6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 NCF1 NCF2 PSMA5 NCF4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 CYBB FGA PSMB4 TAP2 CYBA FGG PSMB5 IKBKG TAP1 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSV CTSL FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGFBP3 FGFBP1 FGFBP2 FGF23 FGF22 FGF16 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis PCNA UBA52 POLH USP10 PCLAF USP43 REV1 ISG15 POLI UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling AKT2 PDE3B NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling OTUD5 ATG5 ATG12 UBE2D1 TRAF3 UBA52 UBE2K CYLD ITCH PIN1 IFIH1 ISG15 TRIM4 PCBP2 UBB UBC RPS27A NLRX1 TBK1 IRF3 NLRC5 UBA7 MAVS RNF125 RNF135 TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 UBE2L6 TRIM25 IKBKE HERC5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 CASP10 TP53 CASP6 ATM CASP1 CASP2 PIDD1 APAF1 NLRC4 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT6A CCT7 CCT4 CCT3 TCP1 ACTB CCT2 CCT8 CCT6B FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I POLR2J POLR2K POLR2L RBFOX2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 NCBP1 NCBP2 HNRNPA1 PTBP1 HNRNPM HNRNPF HNRNPH1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation PRKCB PRKCA STX4 PRKCG STXBP3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL11B SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A BCL7A DPF2 BCL7C BCL7B SMARCA4 SMARCC1 SMARCC2 ARID1A SMARCE1 ACTB RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling CREBBP RBPJ MAML2 MAML1 KAT2B KAT2A HES1 SNW1 EP300 JAG1 RUNX3 MAMLD1 MAML3 NOTCH1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand LIG1 PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression RXRA SP1 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B MYF5 TCF3 HELLS TCF12 KLF16 RARA SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM ADRM1 OAZ3 PAOX AZIN2 AZIN1 PSMC5 AGMAT PSMC6 SEM1 PSMC3 SMS PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNAT3 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 GNG12 GNG11 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A PIK3CA IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 PLD4 V2-19 V1-11 PLD3 V1-16 V1-13 PLD2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 PRKCD PLPP5 PLPP4 SYK AHCYL1 PRKCE DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses AP2A1 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 ARHGEF9 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 BCHE PRKCA SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT SLC6A1 CPLX1 RIMS1 ALDH5A1 DNAJC5 GIT1 HSPA8 VAMP2 CAMKK1 CAMKK2 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 SYN3 SYN2 HRAS SLC6A11 PDPK1 ARL6IP5 CACNA2D1 CACNA2D3 NRAS CHAT GRIP1 MAPK1 GNAT3 SLC6A4 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 SLC18A3 CHRNA1 CHRNA3 SLC17A7 CHRNA2 MAPK3 CHRNA5 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 GRIK4 GRIK1 GRIK2 GRIA1 GABRR3 CAMK2B GABRR2 GRIA2 GABRR1 CAMK2D NPTN SRC ACTN2 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B PICK1 NRGN GRIN2D GNAI3 AKAP5 GRIN1 GNAI1 DLG1 GRIN2A NCALD GNAI2 DLG2 CHRND DLG3 LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption MGAM SLC5A1 SLC2A5 SLC2A2 SI CLPS LCT PNLIP ALPI RSC1A1 PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF PIR PNLIPRP3 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLL1 DYNLL2 IFT172 KIFAP3 IFT52 IFT57 DYNC2H1 IFT140 WDR35 IFT88 KIF3A TTC21B WDR19 IFT122 KIF3B KIF3C DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 KIF17 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 TNPO1 CLUAP1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MTIF2 MRPS25 MTIF3 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MRPS17 MRPS15 MRPS16 MTFMT MRPS14 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME PON3 ABCB1 UGT1A3 SLCO1B1 SLCO1B3 PON1 ABCC2 CYP3A4 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA DDX21 ETF1 GSPT2 GSPT1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B UPF3A CNOT10 SMG1 SMG9 SMG7 SMG8 SMN2 SMG5 CNOT11 SMG6 UPF2 UPF1 PNRC2 NOP58 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 TYW5 GEMIN8 TYW3 TRMT5 DDX20 TYW2 TYW1 LCMT2 ADAR ADARB1 TNKS1BP1 RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPLP0 RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 LTV1 RRP1 GTF2H4 GTF2F2 FTSJ3 GTF2H5 EBNA1BP2 ISG20L2 CDK7 ERI1 ERCC3 LAS1L ERCC2 MNAT1 NOL12 RBM28 NOB1 RIOK2 RIOK1 TEX10 SENP3 GNL3 C1D NIP7 NOL9 EXOSC10 PES1 RIOK3 WDR18 WDR12 BYSL APOBEC1 BOP1 TSR1 APOBEC3C APOBEC2 MPHOSPH6 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B XRN2 HBS1L NT5C3B SKIC3 DCPS SKIC2 SLIRP MTPAP LRPPRC CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 NOP56 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PPP2R1A TP53RK STEEP1 TCERG1 EIF4A3 GPATCH1 RPS27 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 PRMT5 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 WDR77 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 PPP2CA ZRSR2 PRPF38A UPF3B NOP2 MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 TENT4A PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA LSM10 SNIP1 NCBP1 LSM11 MTREX NCBP2 TXNL4A PPP2R2A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 SEM1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 PHAX SNRNP27 PPIE TRUB2 SRSF3 MTERF3 SNRPE NSUN4 SRSF4 FASTKD2 PPIH MTERF4 PPIG SNRNP25 TFB1M SNRPF MRM1 SRSF5 MRM2 SNRNP200 MRM3 SRSF6 RCC1L SNRPC RPUSD4 SRSF7 NGRN SRSF8 RPUSD3 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 RPS4Y2 SNRNP48 RPS27L BUD13 RPS4Y1 TRMT10C PPIL3 PRORP PPIL4 RPS4X ELAC2 RPS15 FAM50A RPS14 TRNT1 HSD17B10 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 PAN2 PAN3 FASTKD5 POP5 TBRG4 POP7 CLNS1A OSGEPL1 SNUPN POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 DDX39B RPP38 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU EIF4E QNG1 EIF4B TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 GRSF1 NSUN6 DUS2 YWHAB QTRT1 HSPB1 GON7 ELAVL1 PSMD8 QTRT2 PSMD6 CTU2 ZFP36 CTU1 PSMD7 TSEN34 URM1 XPO1 PSMD2 LAGE3 KHSRP RPP14 PSMD3 TRDMT1 AKT1 RTRAF PSMD1 TRMT10A ADAT1 TNPO1 NUP214 TPRKB TRMT1 DIS3 PRKCD ADAT3 PRKCA TRIT1 ADAT2 YWHAZ PSMA5 XPOT PSMA6 TRMT6 PSMA3 FAM98B PSMA4 TRMT61A PSMA1 TRMT61B XRN1 RAN PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 CSNK1D EXOSC5 PSMB5 CSNK1E EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ZNF473 IGF2BP1 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 GAR1 NHP2 NOP10 DKC1 PELP1 ZC3H4 ZC3H3 EIF4A2 REXO2 IGF2BP3 EIF4A1 DDX49 TUT7 IGF2BP2 DDX47 TUT4 WDR3 DXO FCF1 ZCCHC7 NAT10 YTHDC1 THUMPD1 YTHDC2 PWP2 ZC3H18 WDR46 PNPT1 WDR43 RBM27 RRP9 RBM26 FBL TENT4B BUD23 SUPV3L1 UTP14A ZFC3H1 UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 PAIP1 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 RPLP1 DHX37 RPL34 RRP36 RPL10L UTP20 RPL8 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 UTP3 RPL18A PNO1 RPL36AL RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A WDR82 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 SKIC8 ZCCHC8 NCL TGS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP ACVRL1 BMPR2 AMHR2 GDF2 UBE2D1 SMAD9 SMAD5 GREM2 ZFYVE16 CER1 BMPR1B BMPR1A AMH NOG ACVR2B ACVR2A INHBA INHA CHRDL1 SKI SMAD1 SMAD4 SMURF2 SMAD7 SMURF1 SMAD6 TGFBR3 BMP2 UBE2D3 FSTL1 BMP10 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay ZFC3H1 PABPN1 SRRT TENT4A EXOSC7 EXOSC6 EXOSC5 EXOSC4 PAPOLG ZCCHC8 EXOSC9 NCBP1 MTREX NCBP2 C1D EXOSC8 EXOSC10 EXOSC3 EXOSC2 EXOSC1 RBM7 MPHOSPH6 ZC3H4 ZC3H3 WDR82 XRN2 DXO ZCCHC7 YTHDC1 YTHDC2 ZC3H18 RBM27 RBM26 TENT4B DIS3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis FTH1 FTL BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN AP3S1 TPD52 CLINT1 DNM2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 IGF2R DTNBP1 ARF1 GOLGB1 NAPA RAB5C TGOLN2 AP3B1 TXNDC5 OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SAE1 SUMO3 SUMO2 SUMO1 UBA2 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes HVCN1 KCNU1 CATSPERB CATSPER1 CATSPERD CATSPER3 CATSPERG CATSPER2 CATSPER4 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis CYP11B1 HSD3B2 HSD3B1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYP11B2 POMC SERPINA6 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP5 GP9 F9 F10 GGCX F8 GP1BA GP1BB F11 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex GPS2 NCOR2 NCOR1 TBL1XR1 TBL1X HDAC3 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes TLE1 TLE5 TLE3 TCF7L2 TCF7L1 CTBP2 HDAC1 CTBP1 LEF1 TLE4 TCF7 TLE2 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD OPLAH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNG13 GNB2 GNAQ GNB1 ADCY9 GNB4 PIK3R2 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB PECAM1 MLST8 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 PIK3CB CALCRL ADM TLN1 CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PIK3CA P2RY2 MMP14 GNG12 MAPKAP1 GNG11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MMGT1 ADD3 DMTN RHCG ADD2 ADD1 TUSC3 CTNS MAGT1 PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 RHAG AZGP1 ANKH MRS2 SLC66A1 NIPA1 NIPA2 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions IQGAP1 PIK3CB NCK2 PIK3R2 NCK1 PIK3R1 ACTN3 KIRREL3 ACTN2 KIRREL1 KIRREL2 ACTN1 MAGI2 FYN CD2AP SPTAN1 NPHS1 CASK WASL PIK3CA ACTN4 SPTBN1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX2 EHHADH ACBD5 AMACR ACOX3 SLC27A2 ACOT4 ACOXL NUDT7 CROT CRAT PECR HSD17B4 HACL1 ABCD1 DECR2 NUDT19 HAO2 ACBD4 ACAA1 PHYH ACOT8 SLC25A17 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling RELA MAP3K7 MAP2K6 IL1R1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 USP14 BTRC NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N NFKB1 CHUK IKBKB SQSTM1 MYD88 IRAK3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL1R2 PSMD13 NFKB2 TOLLIP PSMA7 PSMB6 PSMB7 PSMB4 MAP3K3 NKIRAS1 NKIRAS2 PSMB5 MAP3K8 IKBKG UBB IKBIP RIPK2 PSMB2 MAP2K4 PSMB3 IRAK4 UBC PSMB1 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism DMGDH CHDH SARDH ALDH7A1 BHMT SLC44A1 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) GP5 GP9 SERPING1 KLKB1 GP1BA F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression CXCL8 DCP2 HSPA5 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EIF2S2 EXOSC4 EIF2S1 EIF2S3 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP EIF2AK3 DIS3 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage IL18 CASP5 IL1B GSDMD CASP3 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis TPH2 DDC ASMT AANAT TPH1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs H2BC9 H2AZ2 POLR2A H4C9 POLR2B H2BC8 POLR2C H2BC5 POLR2D H2BC3 POLR2E RAN POLR2F H2BC1 POLR2G POLR2H POLR2I POLR2J H2AC20 POLR2K POLR2L IPO8 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B AGO1 H3C8 AGO2 H2AC8 TNRC6A H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling YWHAE NGFR NGF CASP2 BEX3 CASP3 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 SEPHS2 SECISBP2 EEFSEC RPS4Y2 SEPSECS RPS27L PSTK RPS4Y1 RPS4X RPS15 RPS14 RPS17 SARS1 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 PNPLA2 DGAT2 MGLL DGAT1 DGAT2L6 AWAT2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism PRSS1 TCN2 CD320 ABCC1 LDLRAP1 CTRB2 CUBN CBLIF MMAB CTRB1 AMN MMACHC MMADHC ABCD4 MTR MTRR LRP2 PRSS3 MMAA MMUT TCN1 LMBRD1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling CBL UBA52 FGF20 ANOS1 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET SOS1 ITGA3 STAT3 USP8 PIK3R1 NRAS PTPRJ RAP1B ITGA2 RAP1A STAM2 MET PTPN1 PTPN11 GGA3 SPINT1 HPN SPINT2 SRC HGFAC LRIG1 CRK LAMA5 SH3KBP1 LAMA2 LAMB3 LAMC3 CBL LAMB2 LAMA1 LAMA4 UBA52 LAMA3 LAMB1 STAM LAMC2 LAMC1 ARF6 RAB4A RAB4B DOCK7 HGS RANBP9 UBB RANBP10 RAPGEF1 UBC PTPN2 MUC20 RPS27A SH3GL3 EPS15 TNS4 SH3GL2 TNS3 SH3GL1 RAC1 HRAS GAB1 HGF PTK2 CRKL PIK3CA ITGB1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX CYP27A1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling GNG13 GNB2 GNAQ GNB1 PPP2R5D ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 MAPK1 GNGT2 GNAT3 PRKACG PRKACA PRKACB PLA2G4A PPP2CA PPP2CB GNA14 PPP1R1B PDE1B GNG3 PDE1A GNA15 CDK5 ITPR1 ITPR2 GNG2 CAMK2B ITPR3 GNG5 GNG4 CAMK2D GNG7 GNA11 GNG8 PDYN CAMK2A PDE4A PDE4D PDE4C GNAI3 GNAI1 GNAI2 OPRM1 CALM1 CAMK2G PRKCD PRKCA PLCB4 POMC PPP3CC PPP1CA PPP2R1B PPP2R1A PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX PPP3CA CAMKK1 PPP3CB CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 GNG10 NBEA PPP3R1 GNG12 GNG11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 FLRT1 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FLRT3 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FLRT2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis MBOAT7 MBOAT1 DDHD2 AGPAT2 MBOAT2 DDHD1 LPGAT1 PITPNB CPNE7 CPNE6 GPAM CPNE1 CPNE3 MFSD2A PISD PLA2G4A PLA1A PGS1 PTDSS2 PTDSS1 TMEM86B PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLA2G2A PLAAT5 PLAAT4 PNPLA8 LIPI LIPH ETNPPL PNPLA3 STARD7 PLB1 PLBD1 MIGA2 MIGA1 PLA2G3 PLA2G15 PHOSPHO1 PLA2G5 PLA2G10 PLA2G6 GPD1 PTPMT1 CHAT PLD4 PLD6 PLD3 CHKB CHKA STARD10 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 ACHE LPCAT1 PLD2 OSBPL10 ALPI GPD2 GNPAT PCTP LPIN1 LPIN2 MGLL PLA2G4F LPIN3 PLA2G4D PLA2G4E GPAT4 PLA2G4B PLA2G4C GPAT3 GPCPD1 CEPT1 AGPAT5 BCHE AGK PLA2G1B LPCAT4 AGPAT1 ETNK2 SELENOI LPCAT3 AGPAT3 ETNK1 AGPAT4 LPCAT2 LCLAT1 PLA2G2F PLA2G2D PLA2G2E PCYT2 PGP PLA2R1 CHPT1 GPD1L ABHD4 ABHD3 OSBPL8 CDS1 PITPNM1 PITPNM3 PNPLA2 OSBPL5 PITPNM2 CDIPT ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B AWAT2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 RXRB MYLIP REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors PHF20 AKT2 POU4F1 POU4F2 TP63 TP73 PPP1R13B TP53 PPP1R13L AKT1 TP53BP2 BANP AKT3 ZNF385A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling SOS1 PIK3R2 PIK3R1 KLRK1 NRAS PLCG1 BTK HLA-E GRAP2 LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 MYD88 TLR7 IRAK1 UBE2V1 TRAF6 IRF7 TLR9 UBE2N MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling RELA NGF SMPD2 IRAK1 ADAM17 NFKBIA ARHGDIA YWHAE TRAF6 PRDM4 BEX3 PRKCI TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ECT2 ITGB3BP ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 LINGO1 MAG OMG RTN4 HDAC2 CASP2 UBA52 UBB RIPK2 UBC RPS27A CASP3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling ATP5MC2 ATP5MC3 ATP5PB ATP5F1C ATP5MK ATP5F1D MT-ATP8 ATP5MJ ATP5F1E MT-ATP6 ATP5MC1 ATP5MG ATP5PO ATP5MF ATP5ME DMAC2L ATP5F1A ATP5F1B ATP5PF ATP5PD MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling PIK3CB SOS1 ANGPT4 SHC1 ANGPT2 ANGPT1 PIK3R2 PIK3R1 TEK DOK2 NRAS HRAS GRB7 PIK3CA PTPN11 GRB14 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER PREB STX5 LMAN2 FOLR1 CTSZ SEC24D CTSC SEC24C COL7A1 SAR1B MIA3 TMED10 SEC22B TMED2 SEC23A SERPINA1 AREG GRIA1 GOSR2 LMAN1 LMAN1L LMAN2L CD59 TGFA F5 F8 CNIH1 SEC24B CNIH2 CNIH3 MCFD2 SEC24A MIA2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A UPF1 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 NCBP1 RPS19 NCBP2 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants ERBIN SOS1 HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants KIT PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion UBC RPS27A RAB7A VPS33B CORO1A HGS RAB5A UBA52 UBB LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis AKR1B15 HSD17B14 HSD17B11 HSD17B1 HSD17B2 CYP19A1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC APPL1 DCC UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 CASP3 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 STAT5A STAT5B CBL CDKN1A PIK3R1 GRB2 NRAS UBA52 GOLGB1 MYO18A FLT3 ETV6 UBB PTPN11 UBC RPS27A BCL2L1 TRIP11 PIM1 HRAS ZMYM2 FLT3LG GAB2 PIK3CA SPTBN1 NOX4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 PTGR1 CYP4A22 CYP4B1 ALOX5AP MAPKAPK2 DPEP2 DPEP1 GGT1 ABCC1 ALOX15 CYP4F22 ALOX5 LTA4H LTC4S CYP4F3 CYP4F8 CYP4F2 CYP4A11 CYP4F11 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 RHOC CDKN1B PPP1R12A RHOA RHOB RAC1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 PPP1R12B DLG4 PPP1CB PRC1 CIT CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage IL18 IL1B CASP4 GSDMD CASP3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 GLTP CPTP CLN3 ESYT1 ARF1 ESYT3 ESYT2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC26A2 SLC22A5 GCKR SLC5A1 GCK SLC5A2 SLCO1B1 SLCO1B3 CP SLC6A5 SLC2A9 SLC67A1 SLC26A4 SLC26A3 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH AVPR1B SLC2A10 AVPR2 AVPR1A SLC24A4 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C SLC5A5 NUP42 NUP85 TPR NUP62 SLC35C1 NUP88 NUP43 RAE1 NDC1 SLC20A2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC24A1 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC17A5 SLC35A2 SLC35A3 SLC9A6 SLC33A1 AVP SLC9A9 SLC35A1 SLC29A3 SLC6A19 SLC4A1 SLC36A2 SLC27A4 SLC4A4 BSG SLC6A14 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC7A7 SLC5A7 SLC7A9 SLCO2A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 CSK HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 PTPRC HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 PAG1 HLA-DQB2 HLA-DQB1 LCK P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR NGF PRDM4 HDAC1 HDAC2 HDAC3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC5 HDAC1 HDAC3 HDAC8 HDAC9 HDAC6 HDAC7 MAMLD1 TBL1X RBPJ CREBBP MAML2 NCOR2 MAML1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 SNW1 HDAC11 HDAC4 HDAC2 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate TST ETHE1 SLC25A10 TSTD1 SQOR SUOX DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 APOA1 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 TLR4 HNRNPA1 STAT2 LY96 MAPKAP1 PDCD6IP FASN C4BPA C4BPB ATG14 HSP90AB1 CTNNB1 C4B_2 SDC4 SDC2 SDC3 RPTOR MLST8 GPC1 GPC3 UBE2I GPC2 GPC5 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H2AC25 NEK2 H2AC21 GTF2F1 GTF2F2 IFIH1 HSPA8 UBR4 NRBP1 PEX19 HNRNPA0 CD2BP2 HNRNPUL1 AUP1 PPIL6 ELAVL2 RICTOR H2AC1 CPSF7 SRRM1 VIM HNRNPC RIPK1 RBMX STING1 NFKBIA MAVS CLEC5A HSP90AA1 H2BC18 BECN1 DAXX H2AC19 H2BC26 H2AC14 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 CDC40 H2AC20 DHX9 HSPG2 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 SF3A1 SF3A2 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN WBP11 PRPF6 SNRPG SRSF2 PPIE NFKBIB SRSF3 F2 SNRPE SRSF4 SNRPF SRSF5 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNG13 GNB2 GNAQ GNB1 KCNJ11 ABCC8 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ACACB ADCY6 ADCY5 GNGT2 RAP1A PRKACG SLC2A1 SLC2A2 PRKACA PRKACB RAPGEF3 FFAR1 RAPGEF4 GNA14 GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 IQGAP1 GNAS GCGR GCG CHRM3 PPP2R1B PPP2R1A ACACA PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 CACNB2 PLCB3 PLCB1 PLCB2 ACSL4 ACSL3 ACLY CACNA1D FASN PPP2R5D STXBP1 INS ADRA2C SYT5 MLX ADRA2A PRKAA2 CACNB3 PRKAG2 PPP2CA STK11 PPP2CB CACNA1A CACNA1E STX1A TKT PRKAB2 KCNG2 AKAP5 GNAI1 GNAI2 AGPAT1 PRKCA CD36 SNAP25 KCNC2 CACNA1C PFKFB1 GLP1R ADIPOQ MLXIPL ADIPOR1 ADIPOR2 TALDO1 KCNB1 KCNS3 VAMP2 AHCYL1 MARCKS GNG10 GNG12 GNG11 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation PSMB3 PSMA5 PSMA6 PSMB1 PSMA3 PSMA4 PSMA1 PSMA2 PSME2 PSMB10 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB8 PSMB9 PSMB5 PSMB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC12 MUC17 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD TBXAS1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CBLL1 CTNNB1 RPS27A CDH1 CTNND1 UBA52 SRC UBB ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A4 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis SEL1L IHH VCP DERL2 ERLEC1 OS9 ADAM17 GPC5 P4HB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 DISP2 PSMC2 SCUBE2 NOTUM SYVN1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins ISCU RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants HRAS NF1 SPRED3 SPRED2 SPRED1 NRAS DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS NCAN CSPG4 CHSY1 BGN DCN BCAN VCAN CSPG5 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 PRSS3 CTRB2 CUBN TCN1 CBLIF CTRB1 AMN LMBRD1 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL HADHB HADHA PLA2G6 PLA2G4A LCLAT1 TAFAZZIN LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism ALDH4A1 PRODH PRODH2 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) VAMP2 SV2C SV2B SV2A VAMP1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism ADA2 SFTPB SFTA3 SFTPA1 ZDHHC2 SFTPA2 CTSH ADRA2C TTF1 ADRA2A DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 ADORA2B ABCA3 GATA6 ADORA2A CKAP4 SFTPD P2RY2 SLC34A2 SFTPC SLC34A1 CSF2RB CSF2RA ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide CA4 AQP1 HBA2 SLC4A1 CA1 RHAG CA2 HBB DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE ABCC6 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 FPR1 FPR3 APP SAA1 FPR2 HEBP1 ANXA1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 TGFB1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SMURF2 EP300 SMURF1 ADRM1 SRC MDM2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 RUNX3 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 CBFB IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 TRAV29DV5 IGLC3 TRBV7-9 TRBC1 IGLC1 IGLC2 IGKV3D-20 TRAV19 IGKV2-30 IGLV3-19 IGHV2-70 TRAV8-4 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 HLA-H HLA-B V2-11 HLA-C V3-4 HLA-F V3-3 V2-17 HLA-G HLA-E V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 CD19 V2-8 V1-20 TREM2 V1-9 V5-4 V1-7 V5-1 CDH1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD40LG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 C3 VCAM1 SIGLEC9 CXADR ITGB7 B2M HLA-A CD8B SIGLEC5 FCGR1A JAML CD99 ITGB2 COLEC12 ITGB1 CD33 ITGAL ITGA4 LILRA3 IFITM1 CD226 CD1D CD1C CD1B cd21 LAIR1 CD1A SLAMF7 LILRB2 SLAMF6 LILRB3 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD22 CD200 CD300A NCR1 NCR3 CD200R1 OSCAR HCST TYROBP LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 SELL KLRK1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 NCR2 SIGLEC1 SIGLEC8 KIR2DS2 SIGLEC7 SIGLEC6 PVR CD96 CD300LB CD8A TREM1 KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 CD300E KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 KLRD1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 CLEC2B FCGR2B CLEC2D NECTIN2 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRND CHRNA3 CHRNA4 CHRNG CHRNE PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UCK1 PUDP TK2 TK1 CDA DCK UPP2 UPP1 TYMP UCKL1 UCK2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCK ZAP70 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM12 ADAM19 SH3PXD2A TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 TICAM1 TLR3 RIPK3 CASP8 FADD SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin PRKCA HRAS SOS1 MMP3 HBEGF EGFR NRAS PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNQ1 CACNG4 KCNE5 AKAP9 CACNG6 CACNG7 CACNA1C CACNA2D2 CACNB2 CACNG8 CACNB1 KCNE1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 SPTAN1 POMT2 FYB1 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 ACTN3 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 CASK FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A IQGAP1 JUP RB1 RBBP4 WASL RBBP7 H2AX PIK3CB KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L NCK2 H2BC21 NCK1 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 SIRPG SKAP2 PIK3CA BANP SPTBN1 ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 H2AC20 KIRREL3 KIRREL1 KDM1A KIRREL2 MAPK1 MAGI2 CD2AP NPHS1 MAPK3 PTPN11 CD47 HDAC2 SRC ACTN2 SUZ12 SIRPA ARID1A TYROBP PTK2B PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 SIRPB1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 PTPN6 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 FYN SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 PTK2 CTSL NECTIN1 ACTN4 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 GUCY1B2 KCNMB4 GUCY1B1 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE5A NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis IMPDH1 ADSL IMPDH2 PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS CAD DHODH UMPS ATIC SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants FLT3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand ACD PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 RPA3 WRN DNA2 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin STAT5A STAT5B JAK2 LEP STAT3 SOCS3 IRS1 PTPN11 IRS2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors ZFP36L2 PAIP1 PABPC1 CNOT4 CNOT6 CNOT7 EIF4E EIF4B DICER1 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 BTG4 CNOT6L CNOT11 EIF4A2 EIF4A1 EIF4G1 PABPN1L EIF4A3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 STAM2 STON1 GPS1 STON2 COPS4 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 SGIP1 AP2S1 AGTR1 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 APOB SNAP91 M6PR SYT2 ARRB1 ARRB2 SCARB2 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 TGOLN2 CHRM2 HGS CD4 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 SLC18A3 DAB2 EPS15L1 EPN1 SYT9 GRK3 PICALM VAMP8 IL7R TFRC CFTR SYT1 IGF2R UBA52 STAM UBB UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG BTC EPGN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9 CYP2C8 CYP2J2 CYP1A2 CYP1A1 CYP1B1 EPHX2 CYP2C19 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GCGR ADCY7 ADCY6 GCG ADCY5 PRKACG PRKACA PRKACB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling APOA1 APOA4 APOB APOA5 GPIHBP1 APOE APOC2 APOC3 LPL APOA2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 CDH11 AGO1 AGO2 TNRC6A TNRC6B CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia CITED2 CA9 ARNT HIF1AN UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 VEGFA PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC HIGD1A PSMB1 RPS27A EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EPO DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) FMOD PRELP B4GALT1 OMD KERA ACAN OGN LUM SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants FLT3 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CSNK2A1 CLOCK DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l ALG9 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 GYG2 GYS2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system JUN TRIM6 IFNA2 TRIM5 TRIM2 IFNA8 TRIM3 CSH1 XAF1 ARIH1 RELA IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 TRIM45 NPM1 TRIM35 TRIM38 TRIM31 OAS2 TRIM34 IFITM3 IFNA10 IFITM2 IFIT5 IFNA21 IFI35 IFI30 IFIT3 IFNB1 EIF2AK2 IFIT2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR IRF8 IRAK1 IRF6 IRF9 SAMHD1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A KPNB1 IL1B KRAS PELI1 MMP1 FNTA MMP2 DNAJC3 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N ADAR IRF1 IRF2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 HSPA1L HSPA2 MAPK8 ATF6 BCL2L11 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 FCER2 CANX UBE2I PTGS2 SUMO1 ALOX5 UBE2D2 UBE2D3 ELOB ELOC RBX1 TRIM25 SDC1 HIF1A GH1 SNAP25 GATA3 LYN INPP5D TNFRSF12A TNFSF12 TNFRSF13C ARF1 TNFRSF11A CD40LG RALA RPLP0 LTBR IL1RN PITPNA LTB BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IFIH1 IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ACTB ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA KPNA2 TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 KPNA7 FKBP5 KPNA4 KPNA5 CSF1R GBP1 KPNA3 MAP3K7 FPR1 SPHK1 MAP2K6 TCP1 MT2A FANCC BCL6 SMAD3 SMAD7 ADAM17 NFKBIA MAVS TAB1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TRAF2 NUP43 RAE1 KPNA1 ILF2 NDC1 TRAF3 RANBP2 TEC TRAF6 SEC13 BIRC2 NUP155 NUP133 NUP210 BIRC3 NUP153 NUP93 USP14 BECN1 NUP50 NUP35 NUP54 NUP37 NOD1 ITGAM ITGB2 ACTG1 FLT3 NOD2 IRS1 USP18 PPP2R1B IRS2 EIF4E3 PPP2R1A PIK3CB IFIT1 PPM1B PML EIF4E2 FLNB FGF2 TNFRSF1B MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 SOX2 TNIP2 GRB10 HRAS PTPN13 INPPL1 FLT3LG TWIST1 IRF5 EIF4A3 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5A SHC1 PPP2R5D PIK3R2 PIK3R1 BST2 NRAS RHOU ALOX15 PTPRJ MAPK1 BIRC5 DHX9 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CDC42 LIFR CD44 PPP2CA PPP2CB CAMK2B HNRNPF CAMK2D SRC CAMK2A CASP1 OPRM1 EIF2AK3 CAMK2G CENPS IFNG UBE2E1 MCL1 CD86 PTK2B UBE2D1 CD80 VEGFA CDK1 IL22 POMC CXCL1 NFKB2 CSK JAK2 HNRNPA2B1 ILF3 IL2RG MMP9 FBXW11 THOC5 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B HSPA5 CCL3L3 CCR5 RAF1 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 YBX1 PRKRA TARBP2 IFNAR1 P4HB PRTN3 TIMP1 POU2F1 PLCG2 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FLNA FN1 BRWD1 BLNK GRAP2 HLA-DQA2 BTRC S1PR1 HLA-DQA1 JAK3 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCN2 STAT2 MMP3 UBE2L6 HERC5 IL23R IL13RA2 IL13RA1 HLA-H IL4R IL23A CDKN1A FSCN1 HLA-B NDN HLA-C LIF NANOG HLA-F HLA-G IGHE HLA-E OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 EIF2S2 ATF2 STX3 EIF2S1 IL10RB EIF2S3 CLCF1 EGR1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C EIF4E IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 GBP5 IL11 PIM1 IL19 IL16 DUS2 PGGT1B IL17RE GBP2 OSMR GBP4 PSMD8 IL17RB GBP3 PSMD6 HMOX1 IL31 SLA IL17C SLA2 PSMD7 IL11RA SOCS2 IL7 PSMD2 SOCS6 IL7R SH2B3 IFNL2 PSMD3 IFNL1 AKT1 IRF7 IFNL3 PSMD1 PSMB8 NUP214 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A FAAP100 UBE2V1 FAAP24 HSPA8 VAMP2 CUL5 ICAM1 TNFSF13 FAAP20 FANCM ADRM1 UBA7 FANCL MAPK14 FANCA MAPK11 PSMC5 FANCB PSMC6 FANCE PSMC3 FANCG PSMC4 FANCF PSMC1 PSMC2 ABL2 HSPA1A EIF4G1 PAK2 RAG2 RAG1 IL32 CASP3 FURIN UBA3 IL34 IL1RL1 GAB3 IL33 TGFB1 UBE2M FCGR1BP LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 B2M RELB IRF3 MAP3K14 HLA-A RNF7 TRIM21 GBP6 RORC RORA TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A FCGR1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 CENPX TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 HSP90AA1 NEDD4 TNFSF4 LTA CBL CD27 TNFSF9 PLCG1 TNFRSF25 TNFSF8 CDKN1B PDE12 OASL OAS1 FNTB OAS3 RNASEL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 EIF4A2 EIF4A1 MAP2K1 HSP90B1 H3C15 NCAM1 STAT3 NFKB1 ITGAX PIN1 FASLG TNFRSF18 PRL IFITM1 PIAS1 SNCA IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 ABCE1 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 AKT3 TRIM8 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CUBN CBLIF AMN HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) ABL1 RAD52 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 RAD50 RAD51 RPA3 RAD17 RAD1 ATM ERCC4 DNA2 ERCC1 RAD9B RHNO1 ATR RAD9A TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins PRKCSH UBA52 GANAB ST6GALNAC3 ST6GALNAC4 MGAT1 GALNT1 MOGS UBB UBC ST3GAL4 CANX RPS27A ST3GAL1 ST3GAL2 UBE2I ST3GAL3 SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 PARP14 PARP8 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle TFRC KIF14 KIDINS220 DSG1 NUDC VANGL1 ARHGAP1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 PLXND1 PRAG1 TXNL1 ALDH3A2 PKP4 ANKRD26 LEMD3 DEPDC1B RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 BLTP3B TNFAIP1 RND2 PTPN13 NISCH GOLGA3 KTN1 CKAP4 FNBP1 KCTD13 FRS2 SCRIB VANGL2 LRRC1 CAV1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 NECTIN2 CADM3 CADM1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation PLK3 PIN1 CDK2 PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 PRKAG2 PRKAG3 NOC2L STK11 TAF7L CDK5 PRKAB2 TP53INP1 MDM2 PRKAB1 MDM4 TAF4B DYRK2 TBP UBA52 TAF9 TAF1L AURKA TAF15 HIPK1 TAF12 BLM TAF13 MRE11 MAPKAPK5 HIPK2 BRCA1 TAF11 WRN BRIP1 TAF8 KAT5 TAF7 EXO1 CHEK1 TAF6 RBBP8 TAF5 NBN UBB TAF4 TOPBP1 TAF3 SUPT16H ATRIP TAF2 BARD1 TAF1 RFC5 UBC RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TAF10 TP53RK TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CHEK2 CSNK2A2 TAF9B RAD50 CSNK2B RPA3 RAD17 CCNA2 TP53 RAD1 CCNA1 ATM DNA2 NUAK1 RAD9B RHNO1 ATR RAD9A TPX2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 ATP6V0D1 TFRC HFE ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 TF TCIRG1 STEAP3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 MCOLN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols RXRA CYP51A1 NCOA2 CYP19A1 POMC ARNT2 CYP7B1 CYP11A1 NCOA1 CYP7A1 CYP1B1 CYP27A1 CYP39A1 CYP11B2 CYP11B1 ARNT CYP21A2 AHRR FDXR CYP8B1 NR1H4 CYP46A1 CYP4V2 FDX1 FDX2 AHR RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 TAX1BP3 RHPN2 RTKN RHOC LIN7B ROPN1 RHOA RHOB DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription KLF4 SP1 TFAP2A ZEB2 FOXP2 FOXJ2 STRAP KLF9 ARID1A FOXA2 RB1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 IL25 TAB1 IL17RE IL17RB IL17C IL17RC IL17RA IL17F IL17A MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts RXRA OSBP NCOA2 AMACR SLC27A2 SLC27A5 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 NCOA1 CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 OSBPL1A ABCB11 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 ESPL1 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A PTTG1 KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMD8 CENPI PSMD6 TAOK1 CENPK PSMD7 CENPL XPO1 CENPM PSMD2 CENPN B9D2 PSMD3 CENPO CENPP PSMD1 CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PSMA5 PLK1 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CLIP1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling ITGA3 LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 SRC LAMB1 LAMC2 LAMC1 ITGA2 MET HGF PTK2 ITGB1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation SOX17 TBX6 POU3F1 YAP1 POU5F1 PAX6 MAMLD1 FOXC2 CXCR4 FOXC1 IHH PAX2 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD4 GSC SMAD3 MIXL1 PAX3 ZNF521 FOXA2 FGFR1 MAML2 DLX5 MAML1 FGF2 FGF4 MYB EP300 SOX2 GATA6 TBXT EOMES MAML3 NOTCH1 BMP4 TCF7L2 TCF7L1 NANOG LEF1 TCF7 ZIC1 CTNNB1 RBPJ TFAP2A TFAP2B CDH1 SNW1 TFAP2C EPHA4 TEAD2 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TBPL2 GATA4 MSX1 PSMA5 OSR1 PSMA6 PSMA3 ZIC2 PSMA4 PSMA1 TRIM33 PSMA2 PAX8 PAX7 PSMD12 PSMD11 NOG PSMD14 NOTO FOXH1 PSMD13 FOXF1 WNT3A PSMA7 PSMB6 SHH ZEB2 PSMB7 SNAI1 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP PSMB1 KAT2B KAT2A LFNG ADRM1 LHX1 PSMC5 PSMC6 SEM1 DLL1 PSMC3 PSMC4 PSMC1 FOXA1 PSMC2 FGF8 SOX1 GBX2 OTX2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation CLTC CLTA AP2A1 AP2A2 KIF5C AP2M1 KIFAP3 KLC1 KLC4 KLC3 KLC2 IFI30 SAR1B KIF3A KIF3B AP2S1 AP1G1 AP1S2 KIF3C SEC23A AP1S1 KIF5B AP1S3 KIF5A AP1M2 KIF4B AP1M1 AP2B1 HLA-DOA AP1B1 KIF4A HLA-DOB LAG3 KIF11 CTSO CTSF CTSE HLA-DMA HLA-DMB KIF15 RILP CD74 SEC24B SEC24A KIF22 SEC13 HLA-DQA2 SEC24D HLA-DQA1 HLA-DPA1 HLA-DRB5 SEC24C HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 DYNC1LI1 CAPZB DYNC1LI2 KIF26A CTSD KIF23 KIF20A KIF18A DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A ACTR1B CTSH CTSC KIF2C KIF2B CAPZA3 DNM1 CAPZA2 DNM2 DYNC1I2 LGMN ACTR10 SEC31A CANX DYNC1I1 DYNC1H1 CTSS CENPE DNM3 SPTBN2 ACTR1A ARF1 OSBPL1A RAB7A SH3GL2 DCTN2 CAPZA1 DCTN3 CTSA RACGAP1 CTSB CTSV CTSL CTSK ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A8 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 PTEN AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol PLCB4 INPP5D PLCG1 PLD4 OCRL INPP5B SYNJ1 PLCZ1 INPP5J PLCE1 ITPK1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC25A5 SLC28A3 SLC25A4 SLC25A6 ARL2 ARL2BP SLC29A4 SLC28A2 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation DOHH EIF5A DHPS EIF5A2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 ACADS HADH CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A COPS3 COPS6 COPS5 COPS8 CHMP3 CHMP6 CHMP7 PLA2G6 DCTN6 DCTN5 DCTN1 GJC1 DCTN4 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 MAN2A1 GJA9 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CHM TMED2 CD59 DNM3 CD55 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 COG8 COG7 COG6 COG5 COG4 COG3 RAB27B COG2 COG1 RINT1 RAB30 RAB36 TF KIF16B SAR1B KDELR2 KIF20B COPB2 COPA TMED10 ARL1 AP2S1 KIF3B AGTR1 MAN2A2 VTI1A LDLR SERPINA1 KIF3C RAB6B RAB39A KIF18B KIF4B AP2B1 ALPP KIF4A COPE KIF12 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 MAN1A2 F5 KIF13B F8 TMED3 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 STX4 KIF6 BET1L KIF27 COPZ1 SH3KBP1 SLC2A8 RAB33B KIF9 KIFC2 KIFC1 CD3G NAA35 CD3D NAA38 VAMP4 PAFAH1B3 ARF5 NAPA NAPB NBAS CHRM2 TMF1 STX16 STX18 GOSR1 GOLGA2 NAPG STX10 CYTH3 ARFRP1 CYTH2 CYTH4 CUX1 VPS51 CD4 VPS53 VPS52 MAN1C1 BNIP1 STX6 VPS54 CYTH1 RIC1 MYO1C GALNT2 ARCN1 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 SNX2 FNBP1L SNX9 SNX5 TBC1D8B PUM1 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 KIF20A TMEM115 CNIH2 CNIH3 MCFD2 MIA2 PPP6R1 TRAPPC6A FTH1 TRAPPC6B SEC22A SEC22C FTL STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF PLIN3 GGA2 GGA1 GGA3 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 TGFA EREG BTC EPGN AKT3 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria AUH DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM MMAA MMUT SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAH YWHAZ SFN SP1 SMAD4 SMAD3 EP300 UBE2I YWHAB PSMC6 YWHAE PDPK1 YWHAQ CAV1 YWHAG FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation FGFBP3 FGFBP1 FGFBP2 FGF1 FGF10 FGF2 FGF3 FGF22 FGF7 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 FRS3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 PIK3C2A MTMR9 MTMR4 MTM1 PIK3R4 FIG4 MTMR7 PIKFYVE PIK3C3 VAC14 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium UNC119B ARL3 CYS1 NPHP3 RP2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway TRAF2 TNFSF10 TNFRSF10B UNC5A TNFRSF10A DAPK1 UNC5B DAPK2 DAPK3 FADD CD14 MAGED1 APPL1 FAS FASLG TLR4 RIPK1 TICAM2 DCC TICAM1 LY96 TRADD CASP8 CASP9 CASP3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine MAOA TOMT SLC6A3 COMT REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling XIAP RACK1 STUB1 TRAF1 UBE2L3 TRAF2 UBE2D1 ULK1 MAPKAPK2 FADD USP4 UBA52 BIRC2 USP2 BIRC3 MIB2 CYLD SPPL2B SPPL2A CLIP3 RBCK1 OTUD7B CHUK IKBKG UBB IKBKB RIPK1 UBC RPS27A USP21 SHARPIN TNF TBK1 OTULIN OPTN TAX1BP1 UBE2D2 UBE2D3 TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA AREG EGF EGFR EREG BTC EPGN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin FST FSTL3 INHBB INHBA SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins RANGAP1 UBE2I SUMO1 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOA1 APOE APOC2 APOC3 LIPG ALB CETP ABCG1 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB SESN2 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SEC13 SZT2 SAMTOR SEH1L NPRL2 NPRL3 TCIRG1 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 ATP6V1E1 FNIP2 KICS2 ATP6V1E2 CASTOR1 CASTOR2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 HRAS FGF18 SOS1 FGF1 FGF2 FGF23 FGF4 FGF9 NRAS FGF20 FGF16 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency TCN2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase CEP41 TUBGCP4 CEP43 TUBA1A PRKACA SMC4 SMC2 YWHAE TUBB4B TUBB4A NUP107 EML4 CDCA5 NUP160 NCAPG YWHAG NCAPH NUP85 NUP43 HSP90AA1 NCAPD2 RANBP2 SEC13 NUP133 NUMA1 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 CPAP KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PRKAR2B PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CCP110 CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 TUBG1 HAUS2 HAUS1 MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 CSNK2A1 DCTN3 HAUS8 HAUS7 CSNK2A2 CEP70 CEP72 CEP192 TUBA4A PCNT CSNK2B CEP76 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 NEK7 MZT1 NEDD1 ALMS1 TUBGCP5 CLIP1 TUBGCP6 TUBGCP3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDKN1A POT1 TERF2IP H2AC20 HMGA2 H1-1 H1-0 H1-3 CDK2 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A RB1 CDKN1B HMGA1 MRE11 KAT5 CCNE2 CCNE1 H2AX NBN H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 CCNA2 TP53 CCNA1 H2BC11 ATM HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation GUSB CD44 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HYAL2 HEXB HEXA CHP1 SPAM1 HYAL1 HYAL3 HYAL4 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion F8 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) GGPS1 RXRA SCD CYP51A1 FASN LSS SREBF2 SQLE MTF1 DHCR7 ACACB GPAM NFYA NFYB NFYC TBL1X NCOA1 SAR1B SEC23A TBL1XR1 MBTPS1 SCAP MBTPS2 SEC24B SEC24A NCOA2 NCOA6 RAN INSIG2 SMARCD3 INSIG1 SEC24D MVD SEC24C CARM1 KPNB1 HELZ2 CREBBP CHD9 SP1 ACACA MED1 TGS1 IDI1 ELOVL6 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses C4A CLEC5A C4BPA C4BPB CDC73 EXOC1 HSP90AA1 SKIC8 DDX3X HSP90AB1 CTR9 CLU RTF1 VTN APOA1 LEO1 PAF1 IFIH1 C4B_2 CGAS RBM10 STAT2 STING1 MAVS UBR4 C1QA C1S MBL2 TRIM25 IKBKE PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 PAX4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI TRPC7 TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport TTPA RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H HDAC1 POLR2K POLR2L MTA2 GTF2H1 ERCC6 GTF2H2 GTF2H3 RBBP4 MTA1 GTF2H4 MBD3 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 RRN3 ERCC2 MNAT1 EHMT2 GATAD2B GATAD2A CHD3 KAT2B KAT2A HDAC2 UBTF POLR1A POLR1B CHD4 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism GNG13 CGA GNB1 TCF7L2 GNB3 KIF5C INS CTSZ SLC30A8 PCSK1 GNAT3 GPR119 SLC30A5 PAX6 CPB2 ISL1 GIP CTSG FSHB DPP4 CTNNB1 INHBB IGF1 SPCS3 INHBA SPCS2 SPCS1 INHA FFAR1 INHBC SEC11A INHBE SEC11C ACHE LHB ACE2 STX1A KIF5B KIF5A P4HB BCHE PCSK2 ERO1B CGB8 CPA3 MME CDX2 ENPEP AGT LEP EXOC8 CPB1 FFAR4 EXOC7 CLTRN ACE UCN CES1 CPE GATA4 MBOAT4 REN PLA2G7 CRHR2 GH1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GRP TSHB CMA1 GCG POMC ATP6AP2 KLF4 MYO5A RAB27A VAMP2 MYRIP CTSD ANPEP GZMH PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism PAH ASRGL1 KYAT1 QDPR IL4I1 PCBD1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription RUNX3 SMAD4 SMAD3 TP53 CDKN1A ZFHX3 TGFB1 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 CLTC RPS6KA1 CLTA AP2A1 AP2A2 AP2M1 RDX MAPK1 NUMB DNM1 DNM2 MSN AP2S1 SH3GL2 RPS6KA4 KIF4B AP2B1 KIF4A SHTN1 DNM3 RPS6KA6 EZR RPS6KA3 RPS6KA5 L1CAM DPYSL2 RPS6KA2 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins HERC2 XRCC4 PARP1 CDKN2A RAD52 MDC1 SP100 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 PIAS4 NSMCE3 NSMCE2 NUP88 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 CETN2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 BLM BRCA1 NUP37 WRN PML RPA1 SMC1A XPC SMC3 STAG1 STAG2 RAD21 TDG SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions SLCO4A1 SLCO2B1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A1 SLC25A10 SLC13A2 SLC22A12 SLC13A3 SLCO1C1 SLC5A12 SLC16A7 SLCO1A2 SLC16A8 EMB SLC13A5 SLC16A3 SLC17A5 SLC16A1 AVP SLC22A7 SLC22A6 SLC22A8 SLC10A6 SLC5A8 SLCO4C1 BSG SLC44A5 SLC44A3 SLC22A11 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLCO2A1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 CRY2 CRY1 ADRM1 FBXL21P PSMC5 PSMC6 PER2 SEM1 PSMC3 PER1 PSMC4 PER3 PSMC1 PSMC2 SKP1 CUL1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland PRL FGF10 TGFA AREG EGF FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 SGF29 NCOA6 KANSL1 PHF20L1 KANSL2 SETD1B KANSL3 SETD1A RBBP5 KMT2D PHF20 BOD1L1 ASH2L MBIP TASP1 KMT2C DR1 KMT2B BOD1 KAT2B KAT2A YEATS2 AKAP8L MEN1 TADA3 PAGR1 KAT8 OGT HCFC2 WDR82 PAXIP1 KDM6A DPY30 KAT14 MCRS1 WDR5 KMT2A PSIP1 ZZZ3 HCFC1 TADA2A DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 GALM CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane F8 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis PCSK1 CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE POMC RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants HRAS NRAS KRAS MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development RPS6KA1 EDNRB ASAH1 DICER1 TRPM1 PAX3 YWHAE SNAI2 TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 PXN SMARCD1 SMARCD2 SMARCD3 RARS1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 SMARCE1 MC4R DARS1 EEF1E1 LIG1 MC3R KARS1 GMPR IARS1 EP300 MC5R SOX2 AKT2 ATP6V1E1 SOX9 ATP6V1G1 ATP6V0B ATP6V0E1 KIT DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H ZIC1 FOXD3 MAPK1 TBX2 HINT1 TFE3 CCND1 MITF ITGA2 SIN3A TFEC ALX3 CDK2 TBX3 CTNNB1 MET ATP6V1C1 GPR143 MAPK3 EPRS1 TNRC6C MOV10 ID1 TFAP2A AGO3 STT3B AGO4 CDH1 UBE2I AGO1 AGO2 DPF1 SUMO1 TNRC6A TNRC6B DPF2 YWHAB DPF3 XPO1 SS18L1 ARID1A GSK3B ARID1B YWHAZ PPARGC1A PLK1 SS18 SMARCB1 CCNB1 POMC WNT3A SOX10 SMARCC1 BRCA1 SMARCC2 MARK3 ACTB ACTL6A CREBBP GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TFEB TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 AKT3 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK2 PANK3 PANK1 DCAKD DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex FRAT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 TCF7L1 HDAC1 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 PPP2CA PPP2CB PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 TLE5 APC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CTBP2 CTBP1 PSMB5 PPP2R1B UBB PPP2R1A PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TLE3 SKP1 CUL1 FRAT1 PPP2R5E MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling CRK ARF6 RAB4A RAB4B MET GAB1 GGA3 HGF CRKL IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA PPIA PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation SMAD2 SMAD4 GSC SMAD3 MIXL1 TRIM33 BMP4 POU5F1 SOX2 TBXT NANOG LEF1 TCF7 EOMES FOXH1 CTNNB1 TBPL2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot PLAT SERPINE1 SERPINB8 SERPINB6 S100A10 PLAU PLAUR SERPINE2 SERPINF2 SERPINB2 PLG ANXA2 HRG PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi ST3GAL4 TMED2 SEL1L RFNG MFNG B4GALT1 FURIN LFNG ST3GAL6 ST3GAL3 ATP2A3 RAB6A ATP2A2 ATP2A1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo YAP1 TJP2 WWC1 STK4 SAV1 WWTR1 STK3 MOB1B YWHAB LATS1 MOB1A LATS2 DVL2 AMOTL2 AMOTL1 YWHAE TJP1 NPHP4 CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA AREG EGF PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK2 CDK4 CCNE1 CDKN1B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) IDH3B CS ISCA2 IDH3A MDH2 ISCA1 ACO2 ACAT1 LYRM4 SUCLG2 KGD4 SUCLG1 CSKMT SDHC TRAP1 SDHD SDHA SDHB OGDH FXN NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH IDH2 SIRT3 DLST IDH3G DLD INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling STAT5A STAT5B UBE2D1 LYN STAT3 UBA52 JAK2 JAK1 STAT1 SOCS1 UBB CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins AQP1 GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 RAB11A PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 AVP GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A RAB11FIP2 MYO5B GNG10 AQP4 AQP2 GNG12 AQP3 GNG11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling NTRK1 CLTC AP2S1 CLTA AP2A1 AP2A2 SH3GL2 NGF AP2B1 AP2M1 DNAL4 DNM3 DNM1 DNM2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation MMP15 COL18A1 COL17A1 MMP19 COL15A1 COL16A1 TMPRSS6 COL13A1 COL14A1 FURIN COL12A1 COL19A1 ELANE COL26A1 COL25A1 COL23A1 ADAM10 ADAM9 PRSS2 MMP8 MMP9 COL9A1 MMP1 COL9A3 MMP2 COL9A2 ADAM17 PHYKPL CTSD MMP3 CTSB MMP20 CTSL MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation IKBKB TASL CHUK IRF5 SLC15A4 IKBKG TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling GNG13 ITGA5 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 SRC GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNAI3 GNAI1 GNAI2 GNG10 ITGB1 GNG12 GPER1 GNG11 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation TRAF2 RELA NFKB1 TRAF6 NFKB2 CHUK IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG IKBKB NFKBIA AGER MAVS RNF135 S100A12 MAP3K1 RIGI APP S100B SAA1 HMGB1 NFKBIB TRIM25 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE NPL NEU2 NEU3 NEU4 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA ST6GALNAC1 CMAS SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 NANP ST8SIA3 NANS GLB1 ST6GAL1 ST6GAL2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL PGM1 GYG1 PYGM PHKG1 PHKG2 GYG2 AKR1E2 AGL PHKA1 PHKB PHKA2 GAA CALM1 PYGB METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins ACE2 CMA1 CTSZ CTSD CPB2 CTSG CPA3 MME ANPEP ENPEP AGT CPB1 GZMH ATP6AP2 ACE CES1 REN REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 VCP TMPRSS2 CTSL HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation CREBBP RPTOR MLST8 HSP90AA1 HSPA8 EP300 CAMK2B CAMK2D HSPB8 HSP90AB1 CAMK2A MTOR DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A CRYAB AKT1S1 FKBP4 HSPA1B CAMK2G INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling STAT5A STAT5B STAT3 PIK3R2 PIK3R1 BRWD1 JAK3 JAK1 CISH TSLP IL2RG SOCS1 IRS1 IRS2 CRLF2 H3C8 SMARCA4 SOCS2 IL7 IL7R RAG2 RAG1 HGF PIK3R3 H3C15 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 FURIN HSPA8 CSNK2A1 HSP90AB1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RXRA CYCS HDAC3 NR1D1 TBL1X NCOA1 ESRRA ATF2 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 TWNK SSBP1 HCFC1 CALM1 PPARGC1A NCOA2 PPARGC1B NCOA6 SMARCD3 NRF1 GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HELZ2 CREBBP CHD9 ALAS1 MTERF1 GABPA MED1 SIRT5 TGS1 PPRC1 MEF2D PERM1 CAMK4 IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 PPARA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK STAT3 PIK3R2 PIK3R1 HDAC1 PLCG1 HDAC3 JAK3 SIN3A ALKAL2 ALKAL1 PRDM1 CD274 IL2RG PTPRZ1 IRS1 DNMT1 PIK3CB PTN MYCN MDK EP300 MYC PTPN6 HDAC2 ALK FRS2 HIF1A PIK3CA NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs NEIL3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MT-ND4L GFM1 GFM2 MRRF MT-CYB MTFMT MTRF1 TSFM MTRF1L MTIF2 MTIF3 MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation FCN3 FCN1 COLEC10 MBL2 MASP1 COLEC11 FCN2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism PAH ASRGL1 KYAT1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PCBD1 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia IVD TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host HBA2 HBB REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels ATP2A3 ATP2A2 ATP2A1 ATP2B4 SLC8A1 ATP2B3 SLC8A2 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors PARK7 PPARGC1A PIAS4 NCOA2 DDX5 NPM1 TRIM28 SIN3A NRIP1 HIPK2 DAXX ZNF131 UHRF2 NCOA1 DDX17 CASP8AP2 CTBP1 MBD1 SAFB TOPORS CREBBP MRTFA NCOR2 BMI1 PIAS3 ING2 SUMO3 SUMO2 EP300 RING1 UBE2I PIAS1 SUMO1 RNF2 CBX8 PHC2 PHC1 CBX4 PCGF2 CBX2 PHC3 ZNF350 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system UBC RPS27A TLR2 B2M UBA52 MRC1 UBB ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria E2F1 PMAIP1 TP53 TFDP1 TFDP2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B2 SLC26A2 SLC26A11 SLC26A1 PAPSS2 PAPSS1 SLC35B3 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2E1 CYP2F1 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2S1 CYP2D6 CYP2A7 CYP2A6 CYP2C19 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling TIAM1 LYN ARPC1B ARPC1A KALRN RHOA ROCK1 ROCK2 ARPC4 CFL1 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ARHGEF28 ACTG1 SDC2 ACTB CDC42 ITSN1 RASA1 YES1 PAK1 LIMK2 RAC1 HRAS LIMK1 FYN GRIN2B GRIN1 PTK2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PCNA AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA ELL CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XPA COPS7B COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 PPIE COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 ERCC5 COPS8 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GRIK5 GRIK3 GNG3 GRIK4 GRIK1 GRIK2 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD PLCB3 PLCB1 GNG10 DLG3 PLCB2 DLG4 CALM1 GNG12 GNG11 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LRP1 RETSAT APOA2 APOM APOA1 BCO2 APOA4 BCO1 HSPG2 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 RUNX3 ITGAL CBFB SPP1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS CYP19A1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis CAD DHODH UMPS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence CDKN2D CDKN2C CDKN2B UBA52 CDKN2A RB1 MAPK1 E2F1 E2F2 E2F3 CDK6 TFDP1 MAPK3 TFDP2 ETS1 CDK4 ETS2 UBB UBC SP1 TNRC6C ERF RPS27A MOV10 ID1 AGO3 AGO4 AGO1 MDM2 TNRC6A MDM4 TNRC6B TP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin MAOA ALDH2 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB14 RHOQ KIFAP3 RALGAPA2 RALGAPB RAB13 PRKAA2 KIF3A PRKAG1 PRKAG2 LNPEP PRKAG3 KIF3B PRKAB2 PRKAB1 YWHAB YWHAE C2CD5 EXOC8 EXOC7 AKT1 YWHAQ CALM1 YWHAG ASPSCR1 YWHAH EXOC4 YWHAZ EXOC3 SFN EXOC6 STX4 TBC1D1 EXOC5 SNAP23 TBC1D4 EXOC2 EXOC1 RALA RAB11A RAB4A MYO1C MYO5A VAMP2 AKT2 SLC2A4 RAB8A RAB10 RAC1 MYH9 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly GJB6 GJB5 GJB7 GJC1 GJC2 GJA3 GJA1 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJB2 GJD4 GJB1 GJD3 GJB4 GJB3 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF22 TGFBR3 GIPC1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling CXCL8 CD86 CD80 IL10RA PTAFR CXCL2 STAT3 LIF IL1RN CXCL1 FPR1 CCL3L3 IL1R2 CCR5 CCL5 IL12B IL12A CCL4 IL18 CCL3 JAK1 IL1A CCL2 IL1B CCL19 IL10 CCR2 IL10RB CSF2 CCR1 IL1R1 CSF3 CCL22 TYK2 CCL20 TNFRSF1B FCER2 CXCL10 TNF ICAM1 PTGS2 IL6 TIMP1 TNFRSF1A CSF1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 GP9 VWF GP1BA GP1BB TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct WFDC2 MECOM OSR1 FGF2 GATA3 HOXB4 ID4 BMP4 HOXA6 PAX8 LHX1 PLAC8 CTNNB1 NPNT PAX2 RET EMX2 PCDH19 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 MET GAB1 HGF PTPN11 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle SEL1L PRKCSH UBA52 RNF185 GANAB PDIA3 EDEM2 UBB UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN ITGA2 GXYLT2 CDH2 PXN SERPINE1 STT3B CDH1 SOX2 EDIL3 ZEB1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants FLT3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX12 PEX3 ACBD5 GDAP1 PEX13 PEX14 PXMP2 PXMP4 ABCD2 PEX11B ABCD3 PEX26 ABCD1 PEX2 ATAD1 PEX16 FIS1 PEX19 SLC25A17 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation B4GALT6 B4GALT4 B4GALT5 MGAT4A ST3GAL4 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 B4GALT2 B4GALT3 MGAT5 ST8SIA3 ST6GAL1 MGAT4C OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions TREM2 PLXNA2 ITGA1 SEMA3E SEMA4A CD72 SEMA5A SEMA4D PLXND1 PLXNC1 SEMA6A PLXNA4 SEMA6D PTPRC SEMA7A ITGB1 PLXNA1 TYROBP PLXNB3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry LY6E TIMD4 AP2A1 TYRO3 FURIN AP2A2 MERTK PIK3R1 UBA3 MAPRE3 EMC4 CD14 AP2M1 UBA1 HSPA5 CD33 HSPG2 CLDN1 CD209 SDC4 ATG7 SDC2 SDC3 AP2S1 AXL AGRN GPC1 AP2B1 UBA7 GPC3 HAVCR1 UBA6 GPC2 UBA5 MRC1 GPC5 GPC4 GPC6 RPSA PROS1 SDC1 CD300A GAS6 RNASEK RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 CDK2 LMNB1 MLH1 UBE2I FIGNL1 TEX12 TEX15 MSH4 MSH5 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B MND1 FIRRM REC8 BLM SYCP3 MRE11 BRCA1 BRCA2 STAG3 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 SPO11 H2BC12L H2BC21 SUN2 SUN1 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 SMC1A RAD50 SMC3 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 STAG1 H2BC11 STAG2 ATM RAD21 ATR H3C15 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS PTDSS2 PTDSS1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 CSNK1A1 PARP14 PARP8 UBA52 ST6GALNAC3 ST6GALNAC4 SRPK2 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD ITPR3 WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 PIK3CA VAV1 VAV2 IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 PLD4 V2-19 MAPK1 V1-11 PLD3 V1-16 V1-13 ELMO2 MAPK3 PLD2 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 PRKCD DOCK1 BRK1 LYN BTK CFL1 PLPP5 PLPP4 ACTB MYO5A YES1 HCK SYK PAK1 AHCYL1 FYN NCKAP1L WASF1 PRKCE PTK2 WASF2 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes IFI6 IKBKB IFI44L FKBP5 ARIH1 UBA7 HSPA5 RIGI CHUK ATF6 ISG15 IFIH1 UBE2L6 TRIM25 HERC5 IFI27 EIF2AK3 IKBKG RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors INSL3 INSL5 RXFP4 RXFP1 RLN2 RXFP2 RLN3 RXFP3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PTK6 CDKN1A CCND1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis SLC2A1 B4GALT1 LALBA SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine AMDHD2 GFPT2 GFPT1 PGM3 NAGK GNPNAT1 UAP1 RENBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) MBD4 PCNA SMUG1 PARP1 NEIL2 NEIL1 MPG PNKP LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 OGG1 RFC2 RFC1 PARP2 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLB POLE2 POLE3 PARG NTHL1 APEX1 TDG ADPRS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling HRAS SOS1 HBEGF SHC1 TGFA AREG EGF EGFR NRAS EREG BTC EPGN PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation JUN XIAP RNF146 USP7 MBD3 TNKS GATAD2B GATAD2A PREX2 PTEN CHD4 SNAI2 RCOR1 TRIM27 WWP2 EED NEDD4 MKRN1 FRK HDAC5 USP13 MTA2 HDAC7 RBBP4 MTA1 REST MTA3 RBBP7 TNKS2 PML AKT2 OTUD3 HDAC1 HDAC3 KDM1A MAPK1 MAPK3 ATF2 EGR1 RPTOR TNRC6C MOV10 MLST8 SLC38A9 CHD3 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 HDAC2 TNRC6A TNRC6B MTOR RNF2 PSMD8 RRAGA PSMD6 RRAGC SUZ12 CBX8 PSMD7 PHC2 RHEB RRAGB PHC1 PSMD2 RRAGD NR2E1 CBX4 PSMD3 LAMTOR2 AKT1 CBX2 LAMTOR1 PSMD1 PHC3 LAMTOR4 LAMTOR3 LAMTOR5 MECOM PSMA5 STUB1 PSMA6 PSMA3 PSMA4 ATN1 PSMA1 SALL4 MAF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 SNAI1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 PPARG AKT3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN NOS3 WASL DNM2 CAV1 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes CREBBP MAFK NFE2L2 ABCC3 EP300 ABCF2 ABCC1 ABCG2 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA ASCC2 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBE2D1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 UBB RPS17 RPS15A RPS16 RPS19 UBC RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 ZNF598 RPS24 RPS27 RPS23 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 IPPK ITPK1 IP6K1 NUDT3 NUDT4 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function SOX10 CTNNB1 JUP CDH19 CTNND1 ZC3H12A CTNNA1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ARAP1 UBC PTK6 RPS27A DOK1 CBL AKT1 UBA52 UBB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBIN HSP90AA1 ERBB2 CDC37 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH KGD4 DLST DLD PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing JUN H2BC9 H2AZ2 H4C9 SEL1L H2BC8 H2BC5 H2BC3 FURIN H2BC1 H2AC20 CCND1 ATP2A3 ATP2A2 MAMLD1 ATP2A1 RBPJ TMED2 TNRC6C RFNG MOV10 MFNG B4GALT1 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 ELANE E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 ST3GAL4 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A LFNG EP300 ST3GAL6 H3-3B H3C8 ST3GAL3 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins APBB1IP TLN1 CRK FN1 SRC BCAR1 RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 NTF4 NTRK2 BDNF PLCG1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 GNAS RAB11A AVP PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 CLOCK NPAS2 HELZ2 RAI1 CREBBP CHD9 NCOR1 MEF2C TBL1XR1 EP300 MED1 TGS1 MEF2D RORC RORA RORB SIRT1 PPARA CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNG13 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ABL1 ADCY1 SPP1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PRKACG PRKACA PRKACB STAT1 PECAM1 GNG3 GNG2 NFKBIA GNG5 GNG4 GNG7 GNA11 GNG8 GJA1 NOS3 PRR5 P2RX7 TRPV4 GNAS PKN2 CACNG7 CAPNS1 CAPNS2 CAPN2 RAMP2 PPP2R1B PPP2R1A CALCRL PIK3CB ADM PRKAR1B PRKAR2B PRKAR1A PRKAR2A PDPK1 CACNB2 PIK3CA P2RY2 ITGB3 ITGB1 MAPKAP1 ITGAV ITGA5 CACNA2D1 PIK3R2 NFKB1 PANX1 HSPG2 CTNNB1 CHUK PTPN1 CACNB1 CACNB3 IKBKB PPP2CA MLST8 MTOR IKBKE AKT1 CALM1 FLT4 KDR IKBKG ANXA2 TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD FYN CACNA1H GNG10 PTK2 GNG12 MMP14 GNG11 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 FZR1 SKP2 CCNE2 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 POLD3 POLD4 POLD1 POLE POLD2 RFC1 POLE4 POLE2 POLE3 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes AIM2 BCL2 RELA BCL2L1 NFKB1 HSP90AB1 NLRC4 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 NLRP1 PYCARD NLRP3 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription CREBBP RBPJ MAML2 FABP7 MAML1 KAT2B HEY1 KAT2A HES1 SNW1 EP300 WWC1 HEY2 DLGAP5 HES5 PTCRA PLXND1 PBX1 HEYL MAMLD1 MAML3 STAT1 NOTCH3 NOTCH1 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing ABHD17C FNTA ABHD17B BCL2L1 ABHD17A RCE1 NRAS PDE6D ICMT HRAS FNTB LYPLA1 PRKCQ ARL2 PRKG2 GOLGA7 KRAS USP17L2 CALM1 ZDHHC9 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism SLC26A2 SLC26A11 SLC26A1 PRKACG SLC2A1 PRKACA PRKACB G6PD B4GALT6 B4GALT5 FUT2 FUT1 TKFC B3GALT4 GALM PCK2 SLC37A1 G6PC2 G6PC3 FBP1 FBP2 SLC35B3 B4GAT1 LALBA SLC35B2 XYLT2 SLC35D2 XYLT1 B4GALNT2 B3GALT2 B3GALT1 FAM20B FUT4 FUT6 FUT5 FUT7 FUT9 B3GALT5 CHPF GALK1 PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 GALE CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 GCKR GCK PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 B3GAT3 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU B4GALT1 NDST4 TKT GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE NUP214 UBA52 MAN2B2 MAN2C1 UBB TALDO1 UBC ABCC5 RPS27A GAPDHS PGD PC GBE1 PYGM CEMIP STAB2 GYS2 LYVE1 PHKG1 HAS1 PHKG2 HYAL2 GYG2 HAS3 EPM2A GNS CHP1 AKR1E2 PHKA1 HAS2 SPAM1 PHKB PHKA2 PPP1R3C NHLRC1 GALT PYGB PYGL B3GALT6 SLC37A4 B4GALT7 ABO IDUA NCAN HEXB HEXA BGN AGL GLB1L3 DCN GLB1L2 BCAN NUP205 POM121 VCAN NUP107 GLB1L HYAL1 NUP188 GLB1 AAAS HYAL3 HYAL4 NUP160 POM121C AKR1B1 IDS CSPG5 NUP42 NUP85 CSPG4 TPR GUSB ARSB NUP62 GYG1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 GYS1 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RHCE PPP2R1B RHD PPP2R1A PGM2 PGM1 FUT3 PPP2R5D DERA G6PC1 B3GNT3 CHST14 DCXR AKR1A1 HSPG2 SORD CRYL1 XYLB MANBA GAA PCK1 ACAN LUM CD44 PPP2CA PPP2CB AGRN FMOD HK1 CALM1 GPI ADPGK ENO1 ENO2 ENO3 HK2 ENO4 HK3 TPI1 PGAM1 PGAM2 MAN2B1 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 ST6GALNAC6 PGK2 PFKL GNPDA1 GNPDA2 PFKM DSEL PFKP DSE UST CHST15 GLYCTK ST3GAL4 KHK SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 ST3GAL2 HMMR ST3GAL3 SLC9A1 UGP2 ALDH1A1 PRPS2 PRPS1 RPEL1 RPE CTSL SHPK PGLS PRPS1L1 RBKS SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 NUP107 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG DNMT1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B CHAT PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC18A3 SLC5A7 TSPOAP1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR2 GNPAT DHRS7B AGPS AWAT1 AWAT2 FAR1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport RHBG RHCG RHAG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases GUCY2C NHERF4 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle ARHGAP26 MPP7 VANGL1 ARHGAP32 ARHGEF7 PIK3R2 PIK3R1 RHOJ ARL13B CDC42 CPNE8 STEAP3 WIPF2 FMNL3 FNBP1L GJA1 FNBP1 SCRIB LAMTOR1 TFRC IQGAP3 SNAP23 ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 SYDE1 OPHN1 GIT1 TMPO DOCK8 WASL OCRL DEPDC1B CDC42EP1 VAMP3 RAB7A TRIO WAS NIPSNAP2 SLC1A5 ARHGAP21 PREX1 STOM PAK1 PAK3 CDC42BPB CDC42BPA PAK2 PAK4 DIAPH3 GIT2 CAV1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 POFUT2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 PSIP1 HMGA1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 RAC1 RAP1B RAPGEF1 RAP1A CRK MET GAB1 DOCK7 HGF CRKL DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events PPP2CA PPP2CB PPP1R1B PPP2R5D CDK5 PRKAR1B PRKAR2B PPP3CC PRKAR1A PDE4A PPP1CA PRKAR2A PDE4D PDE4C PPP3CA PRKACG PPP3CB PRKACA PRKACB PPP3R1 CALM1 PPP2R1B PPP2R1A SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling PRKCA SOS1 HBEGF SHC1 EGF ERBB2 EGFR NRAS NRG1 HRAS PRKCE EREG NRG3 NRG4 PTPN12 NRG2 BTC PRKCD MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer CDKN1A RPS6KB2 CDKN1B RICTOR CHUK FOXO4 BAD MLST8 FOXO6 FOXO1 AKT2 TSC2 MDM2 NR4A1 MTOR PRR5 PDPK1 FOXO3 AKT1S1 GSK3A AKT1 CASP9 GSK3B MAPKAP1 AKT3 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones RUVBL1 KANSL1 KANSL2 KANSL3 H2AC1 EP400 KAT7 ATXN7 SUPT20H ATXN7L3 TADA3 ING4 ING3 PAX3 OGT SUPT3H TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 WDR5 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2BC18 DMAP1 MRGBP TAF9 TADA1 VPS72 MSL2 MSL3 MSL1 TAF12 RBBP7 H2AC19 H2BC26 H2AC14 USP22 H2BC21 TAF10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 H2BC9 BRPF1 H4C9 BRPF3 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 ATF2 PHF20 ING5 SAP130 KAT8 TRRAP H2AC17 BRD1 H2AC12 KAT14 MEAF6 ZZZ3 HCFC1 TADA2A SGF29 NCOA2 TADA2B H2AC25 EPC1 H2AC21 KAT5 ACTB CLOCK ACTL6A CREBBP YEATS4 MBIP DR1 KAT2B KAT2A YEATS2 KAT6A MCRS1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation INS GRB10 IRS1 INSR IRS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells HRAS RASGRP3 NRAS RASGRP1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events CXCL6 CXCL9 CXCL8 TAS2R10 CXCL13 TAS2R13 CXCL3 TAS2R14 CXCL2 TAS2R16 ADCY9 CXCL5 CX3CL1 GNAL ADCY4 CXCL16 ADCY3 CCR9 ADCY2 CCR8 ADCY1 CCR7 ADCY8 KNG1 CCR4 ADCY7 CCR3 ADCY6 CCL13 ADCY5 CX3CR1 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCR6 CCL5 PPBP CXCR3 CCL4 RGSL1 OPN3 CCL1 RRH TAS2R40 CCL19 TAS2R41 CCR2 RGR TAS2R43 CCL16 OPN5 PLA2G4A TAS2R46 CCR10 CCL25 CCR1 CCL21 FPR2 CCL20 CXCL10 PDE1B CXCL11 RXFP4 PDE1A CXCL12 ITPR1 GPR17 ITPR2 ACKR3 TAS2R30 ITPR3 TAS2R31 CCL28 RXFP3 CCL27 PSAP TAS2R38 NMS PDYN NMU AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 SSTR3 GPR37 ANXA1 GPR31 PLCB4 GNAS GPR55 MTNR1A TAS2R50 MTNR1B MCHR1 RLN3 LPAR1 LPAR2 LPAR3 LPAR5 PPP3CC MT-RNR2 CHRM2 INSL5 PENK S1PR3 S1PR2 APLN GPR37L1 CHRM4 S1PR5 TAS2R19 S1PR4 PMCH TAS2R42 RGS4 TAS2R45 RGS5 PPY RGS3 RGS1 TAS2R60 CASR OXGR1 GAL MCHR2 NPB NPW NMUR2 NMUR1 NPY2R NPY1R APLNR PRKAR1B SUCNR1 BDKRB2 PRKAR2B HCAR2 BDKRB1 PRKAR1A HCAR3 PRKAR2A PRKX HCAR1 PPP3CA PPP3CB GNAT2 PYY RGS18 TAS2R9 RGS17 PLCB3 RGS19 PLCB1 HEBP1 RGS13 PLCB2 RGS16 P2RY12 GRM3 PPP3R1 P2RY13 P2RY14 GRM2 GRM7 P2RY4 RGS21 ADORA3 GRM6 ADORA1 GPER1 GRM8 NPY5R SSTR1 SSTR2 HRH4 SSTR4 SSTR5 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 HTR1E CNR2 CNR1 HTR1F OPRD1 HTR1D HTR1B ADRA2C HTR5A ADRA2B C5AR1 ADRA2A C5 TAS2R7 PTGDR2 PTGER3 TAS2R8 AGT GRM4 TAS2R1 TAS2R3 PRKCD TAS2R5 PRKCA TAS2R4 PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG GNG10 NBEA GNG12 GNG11 GNG13 GNB2 GNAQ C3 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 OPN1LW GNAZ GNA14 GNG3 CDK5 GNA15 OXER1 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 OPN1MW RGS11 RHO GNAT1 PPP2R1B PPP2R1A PPP2R5D NPY MAPK1 GNAT3 PPP2CA PPP2CB PPP1R1B CXCR1 CCL4L2 CXCR2 RGS8 CAMK2B PCP2 CAMK2D SRC GPSM1 GPSM2 CAMK2A PDE4A GPSM3 PDE4D PDE4C GNAI3 RGS14 RGS20 GNAI1 RGS22 RGS10 GNAI2 RGS12 OPRM1 SST CALM1 CAMK2G OPN1SW GABBR2 GABBR1 OPRK1 POMC CXCL1 PPP1CA TAS2R20 CAMK4 APP SAA1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 BDH2 BDH1 HMGCL HMGCS2 HMGCLL1 AACS ACAT1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 LYN PLCG2 PLCG1 EPO EPOR IRS2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain F8 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MTA2 ERCC6 RBBP4 MTA1 MBD3 MTA3 TTF1 RBBP7 H2AX EHMT2 GATAD2B GATAD2A H2AB1 H2AC19 H2BC26 H2AC14 CHD3 H2BC12L H2BC21 CBX3 H3-3B H3C8 HDAC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CHD4 H3C15 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD HNMT MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 HSPE1 HSPD1 ESR1 LONP1 CAT NRF1 DEFA5 HSF1 DNAJA1 HSPA1A SOD2 SIRT3 FOXO3 AKT1 HSPA9 HSPA1B HTRA2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH ADHFE1 D2HGDH NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown NUP85 PRKCA TPR NUP62 BANF1 PLK1 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 VRK1 CDK1 NUP153 LEMD2 NUP93 NUP50 NUP35 EMD NUP54 LMNB1 NUP37 LEMD3 CNEP1R1 LPIN1 LPIN2 LPIN3 PRKCB NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 S PHASE%REACTOME%R-HSA-69242.5 S Phase ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 CDCA5 RB1 CDKN1B FZR1 E2F1 RBBP4 SKP2 CABLES1 ESCO1 ESCO2 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 CKS1B MAX POLD3 POLD4 POLD1 POLE POLD2 RFC1 AKT2 PDS5B SMC1A SMC3 PDS5A WAPL POLE4 STAG1 STAG2 RAD21 POLE2 POLE3 PTK6 CDKN1A CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B RBL2 ANAPC15 ANAPC16 ANAPC7 CCNH UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones ATP6V0D1 SRPRB TPP1 PREB CXXC1 HDGF PPP2R5B KDELR3 SHC1 ADD1 DCTN1 HSPA5 SEC31A ERN1 EXTL2 PLA2G4B EXTL3 HYOU1 GSK3A ACADVL PDIA6 DNAJB11 SERP1 WFS1 TLN1 DNAJC3 CUL7 FKBP14 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 CTDSP2 SRPRA MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 TSFM MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 GFM1 MRPS17 MRPS15 MRPS16 MRPS14 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PHF20 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 MDM2 PSMC5 MDM4 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 GNE CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) FZD2 GNG13 FZD5 FZD7 WNT5A FZD4 GNB2 WNT16 FZD6 GNB1 WNT1 FZD1 GNB4 FZD8 GNB3 PTHLH GNB5 GNGT1 GNGT2 GIP IHH SMO PTCH1 GNG3 FZD10 GNG2 GNG5 GNG4 GNG7 CRHBP ADCYAP1 GNG8 ADCYAP1R1 CD55 WNT10A FZD9 UCN PTH1R UCN3 UCN2 PTH2R WNT7B GNAS CRH WNT7A GCGR GCG PTH2 WNT3A ADGRE5 ADGRE3 WNT9A GLP1R SHH VIPR1 DHH VIPR2 CRHR1 SCT WNT3 RAMP2 GIPR CALCA GHRHR GLP2R RAMP3 WNT8A CALCB WNT8B SCTR CALCR GHRH CALCRL VIP ADM2 ADM IAPP RAMP1 PTH WNT10B WNT9B WNT6 WNT4 WNT2 PTCH2 WNT2B ADGRE1 GNG10 ADGRE2 WNT11 GNG12 FZD3 GNG11 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic STX5 BET1L GOLIM4 RAB33B RAB41 GOLGA5 ARF1 NAPA NAPB COG8 COG7 COG6 STX16 NSF COG5 MAN2A1 COG4 GOSR1 COG3 NAPG COG2 COG1 CYTH3 RAB30 CYTH2 RAB36 CYTH4 CUX1 MAN1C1 SNAP29 STX6 MAN2A2 VTI1A CYTH1 RIC1 RAB39A RGP1 ALPP TRIP11 GOSR2 MAN1A2 VPS45 YKT6 MAN1A1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation B3GNT5 B4GALT6 B4GALT5 MMRN1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ADAMTS13 GALNT10 GALNT9 POMT2 GALNT8 B3GALNT2 B3GNT9 QTGAL SLC35A4 B3GNT8 FKRP CRPPA B3GNT6 GALNT1 POMT1 CHST4 POMGNT2 GCNT1 POMGNT1 GCNT3 B4GAT1 GCNT4 MGAT5B GCNT7 CHST10 GALNT7 GALNT6 POMK DAG1 GALNT5 RXYLT1 GALNT4 LARGE1 A4GNT LARGE2 GALNTL5 GALNTL6 FKTN GALNT2 POFUT2 B3GNT7 B3GNT4 B3GNT2 POFUT4 POFUT3 EMID1 MMRN2 MUC13 B3GNT3 GALNT12 SEMA5A SPON2 SEMA5B SPON1 ST6GALNAC2 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 ST6GAL1 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ST6GALNAC3 ADAMTS14 ST6GALNAC4 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification NR5A1 PCNA SEL1L RELA CP NPM1 RNF185 NR3C1 SP100 DERL1 DERL2 RNF5 RAB9A RAB9B OS9 VDR ARF4 IL6 SENP5 SENP2 NOP58 CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 SHISA5 PDIA6 MXRA8 SPARCL1 AURKA SCG2 GBF1 TGOLN2 STC2 PENK RAB11A IGFBP7 NDUFAB1 AMELX POMT2 WFS1 B3GALNT2 AMBN ZNF131 TMEM132A SLC35A4 FUCA2 UHRF2 FKRP HRC CRPPA DDX17 CASP8AP2 POMT1 MELTF MBD1 SERPINA10 POMGNT2 MIA3 SAFB POMGNT1 B4GAT1 MSLN TOPORS PRSS23 MGAT5B CHRDL1 CHST10 BMP15 POMK DAG1 RXYLT1 LARGE1 MEPE LARGE2 DNAJC3 B4GALNT2 RCN1 FKTN PIAS3 VGF ENAM AMTN VWA1 FAM20C FAM20A DDB1 MFGE8 UBE2V2 ITIH2 COPS7B SERPINC1 XPC AFP COPS7A FSTL1 FSTL3 CST3 APOL1 CUL4A TOP2B TOP1 SERPIND1 COPS3 GOLM1 POFUT2 COPS6 COPS5 NUCB1 NOTUM UBE2N POFUT4 COPS8 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGO DCTN6 PIGN DCTN5 PIGP DCTN1 PIGZ DCTN4 PIGW NR3C2 PIGV PIGY PIGX LRRC49 PIGC PIGB CAPZA3 PIGA PIGM PIGL CAPZA2 PIGG PIGF ACTR10 PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 SQSTM1 TTLL1 CHM TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H TFAP2B ING2 SPRN SPACA4 TFAP2C NICN1 UBE2I MDGA2 SUMO1 RECK MDGA1 NRN1 ART3 UBE2D2 ART4 UBE2D3 NTNG1 NTNG2 HIF3A RAB22A CD59 CD52 CD55 ELOB PRND ELOC RBX1 CNTN5 ALPL EPAS1 CNTN3 CNTN4 CUL2 ALPG HIF1A TEX101 VHL RAB40A RAB40B ZNF350 RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 ACTB PTP4A2 DCAF7 RTN4RL1 TTL TUBB6 RAB20 TUBB3 RAB25 TUBB1 RAB26 FBXO4 SVBP RAB23 FBXO6 RAB29 RAB15 RAB19 RAB17 FBXW4 TTLL10 FBXW5 NFU1 FBXW10 TTLL13 MEN1 TTLL11 FBXW7 TTLL12 FBXW9 IGFBP1 UMOD LIAS OTOA FBXW2 RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C TP53 LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FBXL3 EIF5A FBXL5 DHPS FN3KRP EIF5A2 TUBA1C FN3K TUBA1B ICMT DOHH TUBA1A TUBB2B FUCA1 TUBB2A USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 WDR5 RAB3D AAAS NUP160 POM121C NUP42 RAB44 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB31 NUP155 RAB37 NUP133 NUP210 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 HDAC7 NUP54 RAB6A TRAPPC1 RBBP5 RAB4B NUP37 RBBP7 CDC20 FCGR3B MRTFA PML DYNC1LI1 DYNC1LI2 RAB24 CDCA8 RAB10 RAB18 COMMD9 DYNLL1 PARP1 BST1 RANGAP1 VNN1 DYNLL2 CTSZ RHOA INCENP BIRC5 CTSC PRMT3 DYNC1I2 COMMD3 AURKB KCTD6 DYNC1I1 DYNC1H1 NR4A2 THRB TFG COPB1 NR2C1 THBS1 GOLGB1 NFKB2 FGA PLAUR FGG CAND1 ANK1 F7 F9 PROC F10 GGCX SKP1 CCNA2 PROS1 PROZ CCNA1 F2 GAS6 CUL1 DBT PCSK9 APOA2 APOA1 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB LAMB2 FN1 LAMB1 LAMC1 BTRC ADAMTS13 MTA1 RPS2 RPS6 EEF1A1 B4GALT2 B4GALT3 LRR1 CCNF B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B CDC34 PSME1 UBE2J2 SEC31A FBXL8 CALR FBXL4 LRRC41 GAN RRAGA SOCS2 SOCS6 KLHL2 KLHL3 IKBKE UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 CETN2 ACTR1A FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 CSNK1D FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 DCTN2 CUL7 CUL5 UBA6 DCTN3 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F YKT6 UBE2H KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W JMJD6 UBA3 RIOX2 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A ANO8 RNF168 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ANKRD28 ASPH ASB9 ASB6 ASB7 PPP6C PPP6R3 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 TP53BP1 GALNT1 ARFGAP3 ARFGAP2 COP1 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SMC1A SEC31B SMC3 TRAPPC2 SEC16B TRAPPC3 TPST2 KTN1 SEC16A STAG1 TPST1 TRAPPC5 TRAPPC9 STAG2 RAD21 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 TDG CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RAD52 RPL8 DCAF13 MATN3 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 HDAC4 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 AMER1 RPL27A AXIN1 APC CDC73 NCOA2 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PNPLA2 CTBP1 RWDD3 UBA2 DNMT1 SAE1 CREBBP AREG NFE2L2 DNMT3B TGFA DNMT3A EIF2AK2 STS MGAT3 ETF1 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG APOB ARSD UBE2L3 USO1 TUBB8 RAB2A TUBB8B SPTAN1 RAB1A RAB1B HGS RAB5A TOP2A GORASP1 UBE2T OTULIN FDX1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 FUT8 MITF GANAB ADAM10 MAN2A1 MGAT5 MGAT1 FBXL18 FBXL7 MGAT2 OST4 EDEM2 ARF3 MOGS DDOST SDC2 MGAT4C TMEM258 DAD1 OSTC MGAT4A TMED2 CANX MGAT4B STT3A STT3B MAN1B1 GPC3 TRRAP CCP110 KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR DCAF8 RNF128 DCAF5 VDAC3 DCAF4 VDAC2 PIAS4 DCAF6 VDAC1 WSB2 CFTR GATA3 OBSL1 BRCC3 DCUN1D5 SNX3 DCUN1D3 RHOT1 DCUN1D4 RCE1 DCUN1D1 DCUN1D2 ZRANB1 COMMD8 SIAH2 INO80 PUM2 ARF1 NPLOC4 STAM DDA1 TADA2B CYLD ANKRD9 H2AC25 UBXN7 COMMD2 H2AC21 COMMD1 BAP1 COMMD6 WDR48 OTUD7A COMMD7 OTUD7B COMMD4 BABAM1 COMMD5 RAB4A SPSB3 IFIH1 CCDC8 BABAM2 CISH UCHL1 TRIM4 CUL9 UIMC1 DPP3 UFD1 UBD IKBKG NAE1 SOCS5 TOMM70 RIPK2 WDTC1 ACTL6A CCDC22 JOSD2 COMMD10 TULP4 UCHL3 JOSD1 DCAF16 DCAF17 UCHL5 DDB2 FEM1C KAT2B DCAF10 KAT2A DCAF11 PTRH2 FEM1A FEM1B PRKN CAPZA1 WDR20 NEURL2 PSME2 NEDD8 ERCC8 USP17L21 USP17L20 GOSR2 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 USP17L12 ARFGAP1 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 PREB OTUD5 TOMM20 YY1 KDELR3 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS RWDD1 JMJD4 ADRB2 KDM8 FOXO4 VCPIP1 JMJD7 ATXN3 RIOX1 ATXN7 OGFOD1 DRG1 NLRP3 DRG2 RIPK1 RCCD1 SUDS3 CLSPN ZC3H15 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 STX5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 USP26 CAPZB USP20 USP21 RAB32 USP22 TAF10 RAB35 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 SCFD1 SPTBN1 RAB39B PARK7 MUC13 RAB8B INS RAB33A RAB7B FGF23 RAB21 CHML RAB11B RAB12 RAB13 ALPI GRIA1 HNRNPK CKAP4 SENP1 CALM1 UBE2C UBE2E1 UBE2D1 UBE2S CDK1 DLAT BLM PIGS BRCA1 PIGU PGAP1 PIGT WRN GPAA1 PIGK BARD1 CDH2 METTL21A KIN FBXW11 METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT RPA1 EEF1AKMT2 EEF1AKMT1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 DDX5 RAB41 KNG1 COG8 COG7 COG6 COG5 COG4 RAB27B COG3 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG MAN1A2 F5 F8 TMED3 MMRN1 MAN1A1 TMED7 TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B U2AF2 GALNT11 ARF5 GALNT14 NAPA GALNT13 NAPB GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GOSR1 NAPG GALNT8 GOLGA2 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 BPIFB2 GCNT1 GCNT3 GCNT4 GCNT7 MAN1C1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNT2 GALNTL6 ARCN1 COPG2 COPG1 LTBP1 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A COL7A1 MDC1 SPTB B4GALT1 DTL MYC ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 PSMD3 PSMD1 SPTBN2 NUP214 PSMD9 PSMD4 PSMA5 PSMD5 PPARGC1A PSMA6 PSMA3 PAAF1 PSME3 PSMA4 PSME4 PSMA1 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 UBA52 PSMG3 PSMG4 PSMD12 PSMG1 PSMD11 PSMG2 PSMD14 PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FOXL2 PSMC2 HIC1 SP3 PPARG PPARA LY6E PEX10 SRD5A3 PEX12 C3 PEX13 PEX14 FURIN BGLAP SPP1 IL33 RNF20 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC HLA-A RORA DLST VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT H2AC19 H2BC26 H2AC14 H2BC21 EP300 SOCS3 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RARA ETFB RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FBXO32 H2BC1 H2AC20 KDM1B NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 RABGGTB RABGGTA GALNT12 DPAGT1 SEMA5A ST6GALNAC1 SPON2 SEMA5B CMAS ST6GALNAC2 SPON1 THSD7B MPI ADAMTS4 HK1 ADAMTSL1 GMPPB NANP ADAMTS5 C1GALT1C1 FPGT ADAMTS2 GMPPA PGM3 ADAMTS3 ADAMTSL5 GNPNAT1 ADAMTSL4 GFUS NANS ADAMTS1 NUDT14 ADAMTSL3 ALG8 ADAMTSL2 ST6GAL1 MUC12 THSD7A ST6GAL2 ALG9 MUC15 ALG6 ADAMTS8 ALG5 ADAMTS9 ADAMTS6 SLC35C1 ADAMTS7 ALG14 ALG2 SBSPON ALG3 MUCL1 MUC3A ALG13 MUC5AC ALG12 MUC3B ALG11 ADAMTS20 ALG1 B3GLCT ALG10 CFP RENBP TRIM28 DHDDS THBS2 ADAMTS12 DPM1 THSD1 DPM2 THSD4 DPM3 ADAMTS10 RFT1 ADAMTS16 MVD ADAMTS15 ST6GALNAC3 ADAMTS14 ALG10B ST6GALNAC4 MUC1 ST6GALNAC5 MUC2 ADAMTS19 ST6GALNAC6 ADAMTS18 GNE ADAMTS17 UAP1 NPL MUC7 FUOM MUC4 NEU2 MUC6 NEU3 MUC16 NEU4 GALNT3 MUC17 DHRSX C1GALT1 GMDS AMDHD2 MUC19 NEU1 SSPOP MUC5B ST3GAL4 ST8SIA4 MUC20 MUC21 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 DPH1 ST3GAL2 DPH2 FBXL21P ST3GAL3 DPH3 MPDU1 DPH5 CTSA DNAJC24 DPH6 NUS1 SLC35A1 DPH7 PMM1 EEF2 ST8SIA1 UBXN1 ST8SIA2 NGLY1 GFPT2 RNF139 PMM2 MLEC ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor BAX NTRK3 NELFB DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing NTHL1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 FUT2 FUT1 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 ABO FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 RHCE RHD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence LIG1 BRCA1 TERT MCM5 MCM2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR CRLF1 TYK2 IL6ST LIF IL11 OSM OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA CTF1 CLCF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways TAS2R10 SEL1L TAS2R13 TAS2R14 TAS2R16 AVPR1B TAS2R40 AVPR2 TAS2R41 TAS2R43 AVPR1A TAS2R46 DERL2 ERLEC1 OS9 TAS2R30 TAS2R31 TAS2R38 TAS2R39 SSTR3 TAS2R50 MCHR1 PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 DNAJB1 GNA13 FGD3 PTGES3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 FKBP4 NGFR ARHGEF35 ARHGEF37 SOCS1 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 CYP26A1 MYD88 CYP26B1 CYP26C1 WWOX TAS2R7 TAS2R8 UBE2D2 UBE2D3 RBX1 EPAS1 HIF1A GRM4 VHL TAS2R1 TAS2R3 TAS2R5 TAS2R4 FES PIP5K1C POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 ACTB TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 CSNK2A1 CSNK2A2 CSNK2B TP53 ARL2 GNG10 CHD8 CBY1 GNG12 SOX3 GNG11 SOX17 GNG13 SRY CCT6A GNB2 SOX6 GNAQ SOX7 GNB1 SOX4 BCL9L CTNNBIP1 GNB4 SOX13 GNB3 PYGO1 BCL9 GNB5 PYGO2 GNGT1 ICMT TUBA1B GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 NUP107 AAAS NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 HECW1 ERCC6L ZWILCH KLHL12 BUB1B WNT3 ACTG1 CCDC88C CDC20 DACT1 WNT8A PPP1CC WNT8B PPP2R1B PPP2R1A CXXC4 KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B CHUK MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 MTMR4 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE DGKG CENPF DGKE DAGLA FMNL1 DGKD FMNL2 CENPH DGKB CENPI DGKA TAOK1 ABHD6 CENPK ABHD12 CENPL PRKCH CENPM DGKZ CENPN DGKQ DAGLB B9D2 CENPO DGKK CENPP DGKI CENPQ DGKH SPC24 SPC25 MAD2L1 DUSP8 CENPS DUSP9 FLT1 FLT4 MRAS KDR VEGFB PORCN VEGFC VEGFD PGF NF1 VEGFA DUSP10 ESRP1 GNA12 SHOC2 SPRED3 SPRED2 SPRED1 CCNT1 CD274 IL2RG NELFB KANK1 STRN MAP2K5 NCBP1 NRP2 NCBP2 CDH5 CDK9 ADH1C CRABP2 ADH1A LFNG CRABP1 JAG1 SDR16C5 ADH4 RDH11 RDH10 RDH16 WNT9B RDH14 RDH13 DLL1 AKR1C3 DHRS3 WNT4 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 SKP1 ALDH8A1 FGFRL1 CUL1 FLRT2 FLRT1 EVC2 IQCE EFCAB7 EVC BOC GAS1 NTRK3 DRC4 PMEPA1 BAMBI NTF3 CDON STRAP WWC1 NEURL1B DLGAP5 HES5 PTCRA RASGRP2 MIB2 RASGRP1 PBX1 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 TACC3 RAF1 PRKACA PRKACB RAPGEF3 RAPGEF4 CYSLTR1 TRPC7 TRPC6 PLCG2 TRPC3 RCOR1 LAMA5 LAMA2 SH3KBP1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 CHRM2 JAK3 CHRM3 CHRM1 CHRM4 CHRM5 HNRNPA1 LIMK2 RPS6 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GPNMB LRRK2 PTK6 RACK1 HBEGF TRAF1 HSP90AB1 TWF1 OPRD1 MSI2 RHOBTB2 ACTN1 TMOD3 LYPLA1 DDX39B RBCK1 PHIP FSHB INHBB INHBA INHA PRKAA1 PRKAA2 PTPRK EPS15L1 CAB39 EPN1 CAB39L PRKAG1 SPRY1 PRKAG2 PTPN3 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR LRRC41 FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 KBTBD7 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 FST ARHGDIB RAC3 FOXH1 ACVR1B EMD LBR ACVR2B GIT1 ACVR2A DRAP1 TMPO SWAP70 ACVR1C ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 RNF41 GARRE1 AMIGO2 NOXO1 CUL5 ARHGAP17 WDR83 SLC1A5 SYNGAP1 ARHGAP15 PAQR3 ARHGAP21 RGL3 LMAN1 RGL2 PAK1 PEA15 PGRMC2 DUSP5 RACGAP1 DUSP2 SLITRK3 DUSP1 NHS ABL2 IL17RD RAPGEF2 SLITRK5 DAB2IP NCKAP1L SEPTIN7 WASF1 CDC14B PAK2 RAG2 YKT6 RAG1 WASF2 PAK4 RASAL1 IL32 RASAL3 GIT2 RASGRP4 CAV1 RASGEF1A ETV4 MCAM RASA3 ERBIN RASA4 ARHGAP26 RASA2 BAIAP2 MPP7 ABHD17C VANGL1 IGF2BP1 MAPK6 ARHGAP32 MAPK4 ABI2 TAOK3 ANGPT1 NOXA1 ABHD17B ABHD17A ABI1 TEK NOX3 ESYT1 FERMT2 NOX1 TGFB1 UBE2M TGFBR1 TGFBR2 LMNB1 CPNE8 OXER1 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG TAX1BP1 FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 STMN1 ARHGAP33 RBFOX2 ARHGAP31 PDGFD DNMBP SHB ARHGAP30 MAP3K11 FGFBP3 FGFBP1 CDC42SE2 FGFBP2 DOCK6 ARHGAP9 ARF6 ARHGAP11B ALKAL2 ALKAL1 DUSP16 DOCK9 TIA1 DOCK8 TNK2 DOCK7 WASL ADAP1 ARHGAP4 ESRP2 SH3PXD2A PTPRZ1 RAMP2 TAGAP CSN2 CALCA PLEKHG3 TIAL1 RAMP3 PLEKHG4 SH2D2A CALCB PLEKHG1 PAG1 CALCR RANBP10 CALCRL ARAP1 GMIP ADM2 PTPRO ARFGAP3 PTN ADM ARFGAP2 IAPP AXL PLAT RAMP1 ARHGAP10 FAM83D CDC42EP5 FAM83A CDC42EP4 MXD4 CDC42EP3 LTK CDC42EP2 THBS4 WAS THBS3 PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B ITGAV COL4A2 NCAM1 ITGA5 COL4A1 PTPRS SPARC ITGB5 SERPINE1 SPOP ITGB6 ITGA2 ITGA8 TGFB2 TGFB3 COL9A1 COL9A3 COL9A2 CHD3 BMI1 RING1 HDAC4 HDAC2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 AMER1 NPHP4 GSK3B CSNK1A1 AXIN1 APC OPN1SW CDC73 LEO1 HHAT SHH DHH ATF1 CREBBP IRAK4 SP1 MAPKAPK3 BCL2 AREG BCL2L1 MYOG PTPN6 MYOD1 TACR2 MYF6 TACR3 TCF4 TAC3 TACR1 MYF5 TAC1 CAMK4 HHIP NTF4 S100B NTRK2 DISP2 SAA1 BDNF ULK3 SCUBE2 TAB3 DZIP1 TGFA TAB2 FOS SPOPL FOXO3 ELK1 PTK2 EREG UHMK1 BTC MC2R EPGN AKT3 JUN FZD7 WNT5A ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SPPL2B SPPL2A CX3CR1 ATP2A3 CLIP3 NSMAF ATP2A2 ATP2A1 PRKG2 OPN3 RRH PTGIR RGR PLA2G4A OPN5 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 RXFP2 RXFP3 CRHBP PDE11A CMKLR1 PDYN AGTR2 FPR3 GALR3 GALR2 NOS3 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 PTH1R UCN3 UCN2 GPR37 PDE10A GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR CDC14A MTNR1A MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 APLN GPR37L1 TAS2R19 KEL TAS2R42 HGS TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R DUSP4 SSTR1 DUSP3 SSTR2 VRK3 WNT16 DUSP6 SSTR4 DUSP7 SSTR5 CORT MAPK7 NPY4R OPRL1 PTHLH CNR2 CNR1 PIP5K1A TSHR PIP5K1B ACKR1 GOLGA7 ZDHHC9 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR TRRAP CCP110 AGT AR CFTR GATA3 SNX3 RHOT1 CSNK1G2 RCE1 ZRANB1 STAM CYLD OTUD7B RAB4A IKBKG RIPK2 UCHL5 KAT2B PIK3CD KAT2A NEDD8 USP9X USP17L2 RNF146 YY1 RUVBL1 MAP3K7 USP8 CER1 USP7 USP4 USP2 STAM2 VCP TNKS ADRB2 FOXO4 RIPK1 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MDM2 TAB1 USP34 PTEN TNFAIP3 ARRB1 RGL1 ARRB2 TRAF2 AXIN2 TRAF6 BIRC2 BIRC3 USP13 USP15 TNKS2 USP21 OTUD3 CKB GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PPP1R1B PDE3A CCL4L2 HNRNPM RGS8 SNW1 PDE8B PDE8A PCP2 HNRNPF GRK3 GRK6 GPSM1 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 PDE7B PDE7A HNRNPH1 MEMO1 CTNND1 AMH NOG CTNNA1 PPP1CA SNAI1 PPP1CB TERT USF1 DDX5 CCR5 CXCR4 NPFFR2 OXTR NPFFR1 RGSL1 GRPR EDNRA EDNRB PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT YBX1 NTSR1 PTBP1 NTSR2 GPR17 NMB XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GCGR GPR4 GCG MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 KIT RGS17 HTR2B RGS19 HTR2C RGS13 ADRB1 RGS16 P2RY6 ADRA1D HTR2A P2RY2 P2RY1 ADRA1B HTR4 RGS21 CCK ADRA1A HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 COL6A2 ADRA2C HTR5A ADRA2B COL4A4 TAAR1 COL6A1 ADRA2A GPR143 COL4A3 ADRB3 ATF2 COL6A3 RBPJ COL4A5 COL6A6 COL6A5 MEF2C B4GALT1 SPINT1 HPN SPINT2 HGFAC POGLUT1 POFUT1 MYL9 VPS29 VPS35 WLS VPS26A TMED5 TLE5 SFN COL1A2 EZH2 HEY1 CASP10 HEY2 MYLK HELLS KLF16 PPARG PPARD SPP1 RICTOR MBD3 STAT1 GATAD2B GATAD2A SKI CCNT2 CDC25C PRDM4 BEX3 CFLAR MAPKAPK5 KMT2B FOXO6 FOXO1 SOCS3 ACVRL1 BMPR2 AMHR2 GDF2 TNFRSF10B SMAD9 TNFRSF10A SMAD5 GREM2 ZFYVE16 BMPR1B NFKB1 BMPR1A TNFRSF10D PIN1 FASLG E2F4 E2F5 SST IL2RA STUB1 TRIM33 CCNK CCNC THBS2 GALNT3 MUC20 SH3GL3 EPS15 SH3GL2 SH3GL1 WWTR1 YES1 SMARCA4 SYVN1 CLTB YAP1 WNT5B ROR1 ROR2 PRICKLE1 RELA WNT1 FZD1 RYK FZD8 RHOT2 RXRG ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 ITCH KLC1 GPAM KLC4 KLC3 KLC2 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH NF2 ACTR3 PRDM1 ACTR2 NR3C1 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B IRAK1 KIF5A NCKIPSD RAP1GDS1 KDM4C IL2 IL3 IL6 BMP2 TCF3 YWHAE PRR5 LEP DPY30 CHD4 YWHAQ YWHAG YWHAH TGIF1 TBP TGIF2 EED STK4 SAV1 STK3 MOB1B MTA2 LATS1 MOB1A LATS2 AMOTL2 PENK AMOTL1 REST CARM1 KRAS CHRDL1 MMP2 MAML2 MAML1 VGF PIP4K2A PIP4K2B PIP4K2C JUNB RNF111 MED1 PRKCB FSTL1 FSTL3 PRKCQ MAML3 NOTUM CRKL MAPKAP1 NEDD4L SORCS3 CGA C3AR1 C5AR2 C5AR1 C5 RET RARG CD19 ASH2L GLI3 GLI2 RSPO3 CD55 TCF12 RARB CDKN2B WWP1 PTPN18 PF4 PTPN12 CSF2 PTPN7 PTPN2 MEN1 MST1 PGR MST1R FKBP5 ABL1 FPR1 SKIL CDK8 TIMP2 CDK5 WDR5 CRH HDAC5 HDAC8 HDAC9 HDAC6 HDAC7 GPR84 RAB6A RBBP4 RBBP5 RAB4B RBBP7 PML HDAC10 HDAC11 SOX2 SOX9 RUNX3 CITED1 PARP1 PRMT1 SGK1 PTPRJ NPY TJP1 FAS CDK5R1 ATP1B4 KCTD6 CXCR1 CBX6 CXCR2 SMURF1 SMAD6 ESR2 NR4A1 NR2E1 CASP2 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 POMC CXCL1 BAX PHB1 ARAF PEBP1 ADGRE5 CSK JAK2 ADGRE3 MARK3 FGB BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 TNS4 TNS3 SYK LCK FYN F2 DBT DLD CLTC CXCL6 CXCL9 CLTA CXCL8 CXCL13 AP2A1 CXCL3 CXCL2 AP2A2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 AP2M1 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 AP2S1 CCL22 CCL21 CCL20 CXCL10 CXCL11 CXCL12 ACKR4 ACKR3 ACKR2 AP2B1 CCL28 CCL27 P4HB POU2F1 STAT5A PXN FLNA GLI1 GRAP2 SUFU BTRC NUMB MTA1 MTA3 PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 GNAO1 NAB1 NAB2 LYL1 F3 DNM2 ARC TRIB1 TPH1 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 ID1 ID4 FOSB ID3 CDK5R2 TGFBR3 LRIG1 SOCS6 SH2B3 IKBKE BAG4 MATK GIPC1 ANOS1 WNT3A OFD1 LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 CSNK1E SFRP2 WIF1 SOST IRS4 IGF1R CILP KDM4B DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 OPN1LW CGN F11R PRKCZ PARD3 SMC1A SMC3 STAG1 STAG2 RAD21 NRG3 NRG4 NRG2 H3-4 ARL13B PDE6D FABP5 FABP7 PLIN3 MGLL GGA3 PDK4 RASGRP3 PIK3AP1 IL5RA CSF2RB CSF2RA STAT5B NCOA2 IL5 IL3RA IL2RB NCOA3 GRB2 NR5A2 CTBP2 CTBP1 DNMT1 PPP5C TNF WNT10B STAT6 PDGFRB FOXA1 ZDHHC7 TLE3 PPID CAV2 GREB1 CHD1 MMP7 TFF3 TFF1 ZDHHC21 CXXC5 USF2 ZNF217 EBAG9 SMPD3 SMPD2 PSAP GSK3A NTRK1 KIDINS220 CRK UBE2L3 TNFSF10 FADD PPP3CC C1QBP SPTAN1 BCAP31 TJP2 FNTA OTULIN TRADD CASP8 FLOT1 FLOT2 DSP DSG1 UACA GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 TMED2 FCER2 RFNG MFNG MDK ACTA2 LINGO1 MAG OMG RTN4 GPC5 ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 UCN CRHR2 TSHB LYN PIK3CG PIK3R6 PIK3R5 BTK RALA CFL1 JAK1 TYK2 AAMP MKNK1 SPRY2 ALK AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 GIP FFAR1 GNAZ ADORA2B JAG2 ADAM17 RDH5 CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 SNAI2 OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 PTPRU WWP2 WDR11 SH2B2 LETM1 CMA1 TMEM59 FER TEC VMA22 GRAP GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 RNF43 ZNRF3 FAM91A1 RSPO2 TEX2 RSPO1 ARMCX3 LGR6 PKP4 LGR5 RASAL2 KLB RSPO4 STIP1 LGR4 DDRGK1 FLT3 PLXNA1 IRS1 ANKRD26 PDE3B IRS2 NSFL1C CPD PIK3CB PLXNB1 TCIRG1 ARHGAP11A IDE FGF1 ZNF512B FGF2 CAPZB FGF3 EFHD2 NCK2 PTPRF FGF4 WDR6 FGF6 NCK1 FGF7 DST FGF9 PLEKHG6 AKT2 NIPSNAP2 BLTP3B GRB10 ATP6V1E1 PARD6B SH3BP1 CTSD WHAMM ATP6V1E2 HRAS WASF3 ATP6V1G1 NDUFA5 PCDH7 ATP6V0B ATP6V0E1 SEMA4F ATP6V1G2 PTPN13 ATP6AP1 VAPB PDPK1 GOLGA3 GAB1 BAIAP2L2 KCTD13 FLT3LG FRS2 TMEM87A GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 SCFD1 SPTBN1 TLR9 EPO EPOR PIK3C3 CCDC88A TRIB3 FRAT1 ANLN FRAT2 ATP6V0D1 FAF2 KIF14 SOS1 SH3RF1 ATP6V0C AKAP12 ATP6V0D2 ATP6V1B1 GFAP HINT2 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 RHOH PIK3R1 RHOF INS RHOJ NRAS RHOU ATP6V0A2 RHOV FGF20 RHOQ THEM4 SAMM50 EMC3 ATP6V1H MTX1 MAPK1 ATP6V0A4 CAVIN1 MYO9A ATP6V0E2 ATP6V1G3 TRIP10 FGF23 RTKN PRAG1 ATP6V1D FGF22 SYDE2 ATP6V1C1 BASP1 ALDH3A2 ATP6V1F ATP6V1C2 ELMO2 DDX4 ATP6V0A1 MAPK3 ARHGEF28 PTPN1 ARHGAP19 INSR ARHGAP18 TOR1AIP1 PTPN11 FGF16 ARHGAP12 PLD2 FGF19 RHPN1 FGF18 RHPN2 FGFR4 FGF10 FAM83B ACBD5 MACO1 SHARPIN ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 CAMK2B DLG5 PICALM CAMK2D SRC DOCK5 ACTN2 DOCK4 ABCD3 CAMK2A NRG1 DOCK3 SOWAHC GRIN2B MTR TNFAIP1 RND2 GRIN2D GRIN1 RND3 RND1 DLG1 CKAP4 DLG2 SENP1 ZAP70 DLG3 GFOD1 LRRC7 ALS2 DLG4 NEFL PEAK1 CALM1 NDUFS3 DOCK2 CAMK2G DOCK1 CCDC187 IER3 MECOM MOSPD2 FAM169A PHLPP2 ADD3 PLK1 PHLPP1 PTK2B CD86 UBE2D1 CD80 HSPE1 ATN1 SLC4A7 ACTC1 SALL4 MAF1 PDHB TRAT1 RPS6KB2 CDK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 GLP1R VIPR1 VIPR2 RANBP9 SCT KAT5 GIPR GHRHR CHEK1 GLP2R SCTR GHRH VIP OPTN PPP1R12A SEM1 APP HGF CLIP1 PDGFB KNG1 IGF2 IGF1 CCR6 PPBP CCR2 TIMP1 S100A9 S100A8 PLG PLPPR1 PLPPR2 PLPPR3 ELANE PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PDGFRA GTF2A1 GTF2A2 BMP10 LTBP4 P2RY12 P2RY13 P2RY14 P2RY4 LTBP3 ADORA3 ADORA1 LTBP1 SCD FASN ITGB8 ULK1 TCF7L2 CDKN1A TCF7L1 HDAC1 LEF1 TCF7 FLRT3 CCND1 SIN3A CDK2 CTNNB1 MET PPP1R15A PTPRA SPTB TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB HSPB1 PSMD8 PSMD6 PSMD7 SPTBN4 XPO1 SPTBN5 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 ARTN PRKCD PRKCA GFRA1 YWHAZ GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 PSMA4 GFRA4 PSMA1 PSMA2 MAPKAPK2 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 CASP9 MMP14 MMP16 CASP3 XIAP C3 DHRS4 FURIN PCSK6 NGF PCSK5 IL1RL1 IL33 RNF20 SPEN IFT172 CCT2 IFT52 CPSF7 ROCK1 IFT57 ROCK2 DYNC2H1 IFT140 GPS1 ADAM12 RPGRIP1L CUL3 TXNL1 KIF7 WDR35 RHOBTB1 SRRM1 IFT88 SMO COPS4 TRA2B GPR161 COPS2 INTU TULP3 MYO6 STK38 KIF3A TTC21B PDE5A RBBP6 PTCH1 WDR19 VIM HNRNPC IFT122 FUZ CCT7 ADCY10 RBMX MKS1 DBN1 DTX4 TBK1 ELMO1 CD28 OPN1MW RASGRF1 RNF31 SPATA2 TNFRSF1A LIN7B OTUD1 TRIM27 HSP90AA1 NEDD4 MKRN1 EGF FRK CBL EGFR CDC37 PLCG1 CDKN1B CCND3 FNTB E2F1 RHO E2F3 GNAT1 TFDP1 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L PELP1 H2BC21 DOK1 MYB EP300 SFPQ IL6R RASA1 KHDRBS1 H3-3B KHDRBS2 H3C8 KHDRBS3 H2AC8 H2AC6 STAP2 H2AC7 SRMS BCAR1 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RARA CBFB H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CETP KDM3A HDAC3 KDM1A KDM1B GNAT3 GPS2 RXRB NRIP1 APOD GABRG3 UGT1A3 APOE GABRG2 TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 GABRB3 NR1H3 GABRB2 NCOR2 ARL4C GABRB1 EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ABCG1 GNAI3 GNAI1 GNAI2 GABRQ GABBR2 GABRA1 GABBR1 ST3GAL4 ST3GAL6 AVP ST3GAL3 MEF2D TAS2R20 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 NKX2-5 KAT2B WWTR1 TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 CCN2 HIPK2 TBX5 GATA4 NPPA ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 ITGB4 COL15A1 ITGA6 PLEC COL11A1 COL11A2 LOX COL10A1 COL27A1 COL24A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL6A3 BMP1 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CTSS TLL2 TLL1 LAMB3 LAMA3 LAMC2 COL1A1 COL1A2 MMP9 PXDN MMP3 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME ABCC5 GSTA2 NUDT15 IMPDH1 HPRT1 IMPDH2 GMPS GSTA1 SLC28A2 RAC1 SLC29A1 TPMT VAV3 NME1 ABCC4 SLC29A2 SLC28A3 GSTM1 NME2 XDH VAV1 VAV2 GUK1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination YAP1 CYP51A1 POU3F1 MPZ SREBF2 ADGRG6 LAMA2 DRP2 HMGCR PRX LAMB1 LAMC1 PMP22 SOX10 NAB1 NAB2 UTRN EGR2 DAG1 POU3F2 MAG HDAC2 TEAD1 WWTR1 SMARCA4 SCD5 MBP ADGRV1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 TRIM27 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PML UBE2I PIAS1 SUMO1 MDM2 NUP205 POM121 NUP107 NUP188 AAAS VHL NUP160 NUP214 POM121C NUP42 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ1 KCNJ16 KCNJ10 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 CNGA2 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 GNG13 GNB1 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC9 METTL23 H4C9 H2BC8 H2BC26 H2BC5 H2BC3 H2BC12L H2BC21 NPM2 H2BC1 H3-3B SRPK1 H1-8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HIRA H2AX PRM2 PRM1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 HNRNPA2B1 SOD2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 MIF SOD1 MTAP GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 PPIA SNRPA1 PAK2 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 CHMP3 CFTR CHMP6 CHMP7 UBA52 ARL13B HBB HDAC6 PLIN2 IFT88 UBB UBC RPS27A PLIN3 CHMP4C CHMP4B VPS28 TSG101 HSPA8 CHMP4A VPS37C VPS37D VPS37A VPS37B CHMP2B MVB12B PCNT CHMP2A MVB12A UBAP1 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer NTRK3 NTF3 PDGFB RICTOR FOXO4 ESR1 MDM2 CD28 PRR5 PTEN GSK3A EGF EGFR CDKN1B KLB FLT3 IRS1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 PDGFRA RAC1 PDPK1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 MAPKAP1 HBEGF RAC2 RHOG PIK3R2 PIK3R1 CDKN1A FGF20 FGF23 FGF22 CHUK MET BAD PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 MLST8 TSC2 ESR2 SRC NR4A1 MTOR NRG1 AKT1S1 AKT1 PIK3AP1 GSK3B CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 RPS6KB2 PIK3R5 STRN PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA FOXO3 HGF EREG CASP9 BTC EPGN AKT3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism CYP27B1 GC PIAS4 CYP24A1 CYP2R1 LRP2 SUMO2 LGMN UBE2I VDR LDLRAP1 CUBN MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis PPIA HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 PARP1 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 FEN1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A POLQ GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALK1 PGM1 GALE GALM GALT AKR1B1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CCNB1 CDK1 ORC5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF COL4A2 COL4A1 SOS1 FURIN STAT3 PIK3R2 PIK3R1 PDGFB NRAS SPP1 COL6A2 COL4A4 COL6A1 COL4A3 STAT1 PTPN11 COL6A3 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 SRC PLG CRK STAT5A STAT5B THBS1 PLCG1 THBS2 PDGFD PTPN12 PIK3CB RAPGEF1 PLAT NCK2 NCK1 THBS4 RASA1 THBS3 PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis PEX3 ABCA10 ABCG4 ABCA3 ABCD2 ABCA6 ABCA2 ABCA5 ABCG1 ABCA9 ABCD3 ABCA7 APOA1 ABCD1 ABCA12 ABCG8 PEX19 ABCG5 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5PO SAMM50 MTX1 APOOL CHCHD3 DMAC2L HSPA9 ATP5MC2 ATP5MC3 ATP5MK ATP5MJ MICOS13 MT-ATP6 MICOS10 ATP5MC1 CHCHD6 ATP5MG ATP5MF ATP5ME APOO DNAJC11 IMMT TMEM11 ATP5F1A ATP5F1B ATP5PF MTX2 ATP5PD WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 CLTC CLTB PRKCA FZD4 WNT5A AP2S1 CLTA AP2A1 AP2A2 AP2B1 AP2M1 PRKCB DVL2 PRKCG ARRB2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation KDELR1 SEL1L RNF185 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 MGAT3 KDELR2 SAR1B COPB2 COPA TMED10 B4GALT6 DERL1 B4GALT5 DERL2 MAN2A2 SERPINA1 RNF5 OS9 COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 TMED7 TMED9 COPZ2 BET1L COPZ1 USO1 ARF5 NAPA GBF1 NAPB SPTAN1 RAB1A RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 GORASP1 B4GALNT2 ARCN1 COPG2 COPG1 B4GALT2 B4GALT3 B4GALT4 CGA RPN2 TUSC3 PRKCSH DCTN6 RPN1 DCTN5 DCTN1 MAGT1 DCTN4 FUT8 GANAB MAN2A1 MGAT5 CAPZA3 MGAT1 MGAT2 CAPZA2 COL7A1 OST4 EDEM2 ACTR10 MOGS ARF3 SEC31A DDOST MGAT4C TMEM258 DAD1 OSTC TMED2 MGAT4A CALR CANX SPTB MGAT4B STT3A STT3B B4GALT1 MAN1B1 ANK2 ANK3 CD59 CD55 SPTBN4 SPTBN5 SPTBN2 ASGR1 ASGR2 UBA52 ACTR1A ARF1 SPTA1 PDIA3 CSNK1D UBB UBC RPS27A CAPZA1 DCTN2 DCTN3 UMOD LMAN1 GOSR2 PSMC1 YKT6 ARFGAP1 PREB SRD5A3 KDELR3 VCP FUCA1 TRAPPC4 SEC22B LHB SEC23A SEC24B GLB1 SEC24A STX5 RAD23B ANKRD28 SEC13 PPP6C PPP6R3 SEC24D SEC24C TRAPPC1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 CTSZ DYNLL2 NSF CTSC DYNC1I2 DYNC1I1 DYNC1H1 GRIA1 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT TFG GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 COPB1 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS GOLGB1 DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 ANK1 SLC17A5 ST8SIA5 AREG ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 UBXN1 ST8SIA2 NGLY1 RNF139 GFPT2 MLEC PMM2 TGFA ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria BAX CYCS BAK1 GSDMD DIABLO GSDME DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBIN HSP90AA1 ERBB2 CDC37 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGA5 FN1 ITGB1 CEACAM1 CEACAM6 CEACAM8 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation SGSH AGRN NAGLU GPC1 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 HSPG2 SDC1 CTSL HPSE SDC4 HPSE2 SDC2 SDC3 IDS UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria E2F1 BBC3 TP63 TP73 PPP1R13B TP53 TFDP1 TFDP2 TP53BP2 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GUSB ARSB GYG1 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 ALDOB EPM2A DCXR GNS SI PPP1R3C LCT HGSNAT NHLRC1 GAA G6PC3 UBB SGSH UBC TALDO1 KHK RPS27A GALNS NAGLU SLC37A4 RPIA IDUA HYAL1 GLB1 IDS SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF10 LAMA5 FGF2 LAMA2 LAMB3 LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection AP2A1 AP2A2 NPM1 AP2M1 CCR5 CXCR4 AP2S1 AP2B1 TAF4B TBP TAF9 TAF1L NMT1 BTRC TAF15 TAF12 TAF13 TAF11 TAF8 KPNB1 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C CHMP4B CHMP4A RAC1 GTF2A1 CHMP2B GTF2A2 GTF2B CHMP2A GTF2E1 GTF2E2 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 TAF7L FEN1 PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 RNMT CCNH PSMA5 PSMA6 POLR2A PSMA3 POLR2B PSMA4 POLR2C PSMA1 POLR2D POLR2E RAN PSMA2 POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J ARF1 PSMD12 POLR2K PSMD11 POLR2L RNGTT GTF2H1 PSMD14 GTF2H2 GTF2H3 PSMD13 SUPT5H PSMA7 GTF2F1 GTF2H4 PSMB6 GTF2F2 GTF2H5 PSMB7 CDK7 ERCC3 PSMB4 ERCC2 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PPIA PSMC5 PSMC6 PSMC3 TAF9B PSMC4 PSMC1 PSMC2 PAK2 FURIN AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NMT2 LIG1 RCC1 TAF10 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 XRCC6 XRCC4 XRCC5 LIG4 RANGAP1 ATP6V1H DOCK2 CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 HCK SEM1 LCK FYN SKP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 EPB41L1 KCNMA1 KCNMB1 CASK KCNQ4 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A MYH9 TMC2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 USH1C SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters SLC17A1 SLC20A2 SLC34A3 SLC34A2 SLC20A1 SLC34A1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events H2BC9 CHMP3 H4C9 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 H2BC1 H2AC20 H2AC1 HNRNPK H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 H2BC18 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 NUP37 VPS36 VPS25 SNF8 CHMP1A H2AC19 H2BC26 H2AC14 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 CEBPD H2BC17 VPS4A CHMP2B H2BC12 MVB12B CHMP2A H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 H3C15 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport KDELR1 KDELR3 DYNLL1 FOLR1 INS BET1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 COG8 COG7 COG6 NSF COG5 COG4 COG3 CAPZA3 COG2 COG1 CAPZA2 DYNC1I2 ACTR10 ARF3 KDELR2 COPB2 COPA TMED10 TMED2 SPTB DYNC1I1 DYNC1H1 COPE ARF4 ANK2 ANK3 CD59 CD55 SPTBN4 TMED3 SPTBN5 SPTBN2 TMED7 TMED9 COPZ2 COPB1 BET1L STX5 COPZ1 USO1 ACTR1A ARF1 ARF5 GOLGB1 NAPA GBF1 NAPB SPTAN1 SPTA1 RAB1A RAB1B GOSR1 GOLGA2 NAPG ARFGAP3 ARFGAP2 CAPZB DYNC1LI1 GORASP1 ANK1 DYNC1LI2 ARCN1 DCTN2 CAPZA1 DCTN3 COPG2 GOSR2 COPG1 YKT6 TMEM115 ARFGAP1 SPTBN1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis B3GNT5 B4GALT6 B4GALT5 FUT2 FUT1 ST8SIA5 UGCG ST3GAL5 UGT8 ST3GAL2 ST3GAL3 B4GALNT1 GAL3ST1 CERK B3GALNT1 B3GALT4 ST6GALNAC5 ST6GALNAC6 A4GALT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RAPL1 IL1RL2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism GCDH HYKK AADAT PIPOX SLC25A21 CRYM AASS DHTKD1 ALDH7A1 DLST PHYKPL DLD TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR2 ARRB1 ARRB2 TGFBR3 TGFB2 TGFB1 GIPC1 TGFBR1 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease SOS1 CEP43 STAT3 PIK3R1 ERLIN2 NRAS FGF20 FGF23 FGF22 STAT1 FGF16 FGF18 FGFR4 FGF10 ZMYM2 FGFR1OP2 POLR2A BAG4 POLR2B STAT5A STAT5B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRIM24 PLCG1 POLR2I FGFR3 POLR2J POLR2K POLR2L GTF2F1 CPSF6 GTF2F2 FGFR1 MYO18A LRRFIP1 CUX1 BCR NCBP1 NCBP2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 GAB2 PIK3CA SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs RPS6KA1 CLTC CLTA AP2A1 AP2A2 FURIN NTRK3 PCSK6 NTF3 NGF PCSK5 AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB PTPRO VGF EP300 JUNB RAC1 HRAS GAB1 FRS2 MAP2K1 CRKL MAP2K2 PIK3CA TIAM1 SOS1 DUSP4 DUSP3 VRK3 PTPRS DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 PTPN11 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 SRC ADCYAP1 ADCYAP1R1 YWHAB SHC2 DOCK3 SHC3 RALGDS GRIN2B DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA BAX ATF1 NELFB BRAF MAP2K5 RAPGEF1 MAPKAPK3 FRS3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTF4 NTRK2 BDNF FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f MPDU1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS ABCC2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling PRKCA SOS1 SH2B2 LYN CBL PTPN6 YES1 LCK FYN KIT SOCS6 SH2B3 SOCS1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) PTPRO SOS1 PTPRS NTRK3 NTF3 PIK3R1 NRAS PLCG1 SRC BAX HRAS PIK3CA NELFB IRS1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A7 SLC4A4 AHCYL2 SLC4A8 SLC4A9 SLC4A10 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion INMT RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins OCLN APC DSG1 DSG3 PLEC ADD1 BIRC2 ROCK1 SPTAN1 LMNB1 CTNNB1 DBNL TJP1 ACIN1 GAS2 MAPT BCAP31 VIM GSN CLSPN TJP2 FNTA DSG2 PKP1 CDH1 BMX SATB1 STK24 STK26 PRKCQ CASP8 CASP6 PTK2 CASP7 DSP CASP3 PRKCD TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands IGFBP3 TNFRSF10C TP63 TP73 PPP1R13B TNFRSF10B TNFRSF10A FAS TP53 TMEM219 TNFRSF10D TP53BP2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR DLAT PDHX PDHA2 PDHA1 PDHB DLD GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR LYN STAT3 SOCS3 ADAM17 PTPN6 MAPK1 JAK2 SOCS2 CISH STAT1 MAPK3 PTPN1 SOCS1 IRS1 IRS2 GH1 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) SEL1L ERLIN1 ERLIN2 RNF185 VCP PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA1D GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY6 CACNA1C ADCY5 GNGT2 ADRA2C ADRA2A CACNB3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 GNAI1 CACNB2 GNAI2 GNG10 GNG12 GNG11 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA PRKCA ANP32A ELAVL1 XPO1 TNFSF13 NUP214 SET PRKCD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0D1 ATP6V1G1 ATP6V0B ATP6V0C ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V1H LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 CDH1 SH3GL1 CTNND1 UBA52 SRC STAM STAM2 CBLL1 CTNNB1 MET HGS UBB SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 ADCY9 TAS2R16 FZD8 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 PDE11A CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 PDE10A GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH TRIO MAS1 RASGRF2 XK ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 WNT6 VAV3 HCAR1 WNT2 ARHGEF11 PTCH2 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ WNT2B ARHGEF15 PLEKHG5 HEBP1 ADGRE1 ARHGEF17 GRM3 ARHGEF16 ADGRE2 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 WNT16 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN ACKR1 FGD1 FGD2 GNA13 FGD3 ABR FGD4 C5AR2 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 WNT3 WNT8A WNT8B PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 CCL11 CCL3L3 PRKACG CXCR5 CCR5 CXCR6 PRKACA CCL7 CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 RGSL1 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HBEGF HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA WNT3A WNT9A PAK1 C3 ROCK1 ROCK2 SMO PTCH1 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants CEP43 STAT5A STAT5B STAT3 PIK3R1 TRIM24 ZMYM2 CPSF6 FGFR1OP2 GAB2 MYO18A STAT1 PIK3CA LRRFIP1 CUX1 BCR FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 TEC IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 VAV3 PPP3CA PPP3CB PPP3R1 VAV1 VAV2 SOS1 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN BTK NFATC3 TXK SYK AHCYL1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation GCSH DLAT LIPT2 LIPT1 NDUFAB1 DLST FDX1 NFU1 DBT LIAS TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 PCNA UBC RFC3 RFC4 POLK RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly CHMP3 CHMP6 CHMP7 RANGAP1 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 PPP2CA TUBA3E TUBA3D TUBA3C UBE2I SUMO1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 TNPO1 NUP160 NUP85 NUP62 BANF1 SIRT2 NUP43 RAN NDC1 CCNB1 TUBB8 SEC13 NUP155 NUP133 IST1 VRK1 CDK1 LEMD2 NUP93 TUBB8B NUP35 EMD NUP54 LBR NUP37 KPNB1 SPAST CC2D1B LEMD3 PPP2R1A TUBB6 TUBB3 TUBB1 PPP2R2A CHMP4C RCC1 CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A CCNB2 AHCTF1 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 RXRB PLIN1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import PEX10 PEX12 PEX13 PEX14 SLC27A2 DHRS4 NUDT7 CRAT PECR ZFAND6 PEX26 SCP2 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 ECH1 PIPOX GNPAT ACOT2 ACOT4 UBE2D2 UBE2D3 NOS2 HACL1 HAO1 DECR2 HAO2 EPHX2 IDH1 TYSND1 UBE2D1 AMACR DAO CAT CROT UBA52 PEX2 PEX1 BAAT PEX7 UBB ACOX2 ACOX1 IDE UBC EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 AGXT PAOX HSD17B4 DDO HMGCL USP9X TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 PLK3 CNOT1 CNOT2 CNOT3 NPM1 CDC25C RGCC PLAGL1 TNKS1BP1 CNOT10 PLK2 CNOT8 CNOT9 CNOT6L CNOT11 TP53 BTG2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site CANX CALR INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling LCK JAK3 STAT5A STAT5B PTK2B SHC1 IL2RB JAK1 IL2RG IL2RA IL2 SYK BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA PHF1 H2BC9 H2AZ2 H4C9 JARID2 H2BC8 H2BC5 EED H2BC3 H2BC1 EPOP H2AC20 AEBP2 MTF2 RBBP4 EZH2 RBBP7 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EZHIP PHF19 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 EZH1 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 AR CFTR BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 NCOA2 PTK2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NCF1 ATP6V0D1 NCF2 ATP6V0C NCF4 ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H HVCN1 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F NOS1 ATP6V1C2 CYBB ATP6V0A1 CYBA LPO TCIRG1 SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B MPO ATP6V0E1 NOS2 ATP6V1G2 NOS3 ATP6V1B2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins NUP85 TPR PCNA NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 INCENP NUP50 BIRC5 NUP35 NUP54 NUP37 TOP2A AURKB PIAS3 SUMO3 SUMO2 UBE2I CDCA8 SUMO1 TOP2B TOP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle TRAK1 TRAK2 RHOT1 RAP1GDS1 MYO19 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS FMOD HEXB HEXA GNS GLB1L3 PRELP GLB1L2 OMD KERA GLB1L GLB1 ACAN OGN LUM RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 BRK1 ABI2 ABI1 ARPC1B ARPC1A ABL1 BTK MAPK1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ACTG1 MAPK3 ACTB CDC42 NCK1 WAS NCKIPSD WIPF1 WIPF2 CYFIP2 WIPF3 RAC1 WASF3 NCKAP1L WASF1 WASF2 PTK2 CYFIP1 NCKAP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PIP5K1C ARHGAP32 FURIN RPN2 PCSK6 JUP PRKCSH RPN1 GANAB CSNK2A3 PCSK7 CTNNB1 POMT2 SPCS3 SPCS2 SPCS1 OST4 SEC11A POMT1 SEC11C MOGS DDOST TMEM258 DAD1 OSTC CANX STT3A CDH1 CSNK2A1 CSNK2A2 ANK3 CSNK2B TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP BLM CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 CHTF18 RFC2 RFC1 STN1 RPA1 TEN1 RPA2 RPA3 DNA2 CTC1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 HRAS SOS1 NTF4 NTRK2 BDNF FRS3 FRS2 NRAS PTPN11 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism SLC2A1 CYB5R3 SLC2A3 CYB5A SLC23A2 SLC23A1 GSTO2 GSTO1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 PSIP1 PPIA HMGA1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release CANX CALR DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 GALK1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 IGHV3-23 V1-13 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-8 V1-20 IGHV3-33 IGKV1D-39 IGKV1D-33 V1-9 V5-4 IGKV2D-28 V1-7 IGKV4-1 V5-1 IGHV7-81 V1-5 V1-3 IGKV2D-30 V5-6 IGHV4-59 IGHV1-69 C1QB C1QA C1S IGLV2-11 C1R IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 V4-6 V4-2 IGKV3-15 V4-1 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 C1QC IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CRP IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair MBD4 H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 SMUG1 NEIL3 H2BC3 H3-4 PARP1 NEIL2 H2BC1 POT1 TERF2IP NEIL1 H2AC20 MPG FEN1 POLB H2AX PNKP LIG1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLE POLD2 OGG1 H2BC21 RFC2 RFC1 PARP2 LIG3 RPA1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 XRCC1 H2BC14 POLE4 H2AJ RPA3 H2BC15 H2BC11 POLE2 POLE3 PARG NTHL1 APEX1 ADPRS TDG MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 ABL1 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 MYBL2 DHFR TK1 CDKN2D CDKN2C CDKN1C RB1 DYRK1A CDKN1B CCND3 RRM2 CCND2 E2F1 RBBP4 E2F2 E2F3 SKP2 CABLES1 FBXO5 CDK6 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 TOP2A PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDKN2A CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN CCNB1 PSMA2 UBA52 CDKN2B PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 JAK2 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PPP2R2A PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBIN HSP90AA1 ERBB2 CDC37 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR FLRT1 SOS1 PIK3R1 NRAS FGF20 MAPK1 FLRT3 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 PTBP1 HNRNPM TGFBR3 HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L GIPC1 ANOS1 FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 SPRED2 SPRED1 ESRP2 KLB TIAL1 BRAF UBB GALNT3 PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 FMOD PRELP CHST6 OMD KERA ACAN OGN LUM ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions GJA10 PANX1 PANX2 GJD2 GJC1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation ARHGDIA NGFR NGF RHOA REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression CREBBP MAFK RELA NFE2L2 EP300 NFKB1 MYC NOTCH1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation ALDH1B1 ADH7 ACSS1 ADH5 ADH6 ADH1C ALDH1A1 ALDH2 ADH1A ADH4 ACSS2 ADH1B EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA1A XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGEF1 ARHGAP32 RHOC ARHGEF5 PIK3R1 RHOA ROCK1 CAVIN1 ROCK2 ABR RTKN ARHGEF28 ARHGAP18 MCF2 ACBD5 MACO1 FMNL3 ABCD3 FMNL2 ARHGDIA CIT ARHGEF25 CCDC187 PKN3 IQGAP1 TFRC IQGAP3 STX5 ARHGAP1 ARHGAP39 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK C1QBP LBR TMPO BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 LMAN1 STOM MCF2L ARHGEF40 RACGAP1 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 VAPB DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants HRAS NRAS KRAS SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border MSX1 DLX5 TFAP2A FGF4 TFAP2B BMP4 MYB TCF7L1 TFAP2C PAX7 POU5F1 SOX2 PAX3 ZIC1 WNT3A CTNNB1 GBX2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 TF CALU SERPINA1 MBTPS1 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 LAMB2 PDIA6 MXRA8 SPARCL1 FN1 LAMB1 SCG2 LAMC1 TGOLN2 STC2 PENK IGFBP7 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC GAS6 APLP2 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC22A5 PPARD CYP4B1 FAAH NUDT7 ACSM3 PCCA CRAT ECI1 PCCB THRSP ACSM6 PTGDS ACAD11 ACAD10 PLA2G4A GGT5 PTGES GGT1 DECR1 ALOX15B LTC4S GPX2 ACADL HADHB HADHA ACADVL ACADM ACADS CBR1 CYP2C9 NDUFAB1 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 SLC27A1 HACD1 TECR HSD17B3 PTGES2 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ACOT9 ELOVL1 OLAH CYP8B1 ELOVL4 ACOT7 ACSL1 MECR ELOVL5 ELOVL2 ACAA2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 HADH ACSL3 ACOT1 TECRL ACSF3 ACLY RXRA SCD FASN ACOT11 PPT1 ACOT12 ACSBG1 ACOT13 PPT2 SLC27A3 ACSBG2 SLC27A2 DPEP2 DPEP1 ALOX15 PECR THEM4 LTA4H PTGES3 CYP4F3 CYP4F8 SCP2 MCAT CYP2J2 NUDT19 ACBD7 PRXL2B ACBD6 ACOT7L ACAA1 ACBD4 PRKAA2 PHYH ACOT8 ACSF2 PRKAG2 MCEE ACBD5 PTGR1 ACOT2 CYP4A22 PTGR2 DBI ACOT4 PCTP ACOXL PRKAB2 ECHS1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 HACL1 PON3 HPGD DECR2 PON2 HAO2 PON1 EPHX2 FADS2 HPGDS FADS1 AMACR ALOX5AP MAPKAPK2 CROT CYP4F22 CPT2 MID1IP1 THEM5 SLC25A20 CPT1B ABCD1 CPT1A CYP4F11 SLC25A17 ACOX2 TBXAS1 EHHADH ACOX3 GPX1 GPX4 FAAH2 AKR1C3 HSD17B4 MMAA MMUT AWAT1 ALOXE3 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP3A7 CYP2E1 CYP2F1 ARNT AHRR CYP2W1 CYP2D6 ARNT2 CYP3A5 CYP2C18 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2J2 CYP2S1 CYP3A4 CYP1A2 CYP3A43 CYP2A7 CYP1A1 CYP2A6 AHR CYP2C19 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry AGRN ACE2 FURIN GPC1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 HSPG2 VCP TMPRSS2 NRP1 SDC1 CTSL SDC4 SDC2 SDC3 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus SQSTM1 UBC RPS27A NGF TRAF6 UBA52 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 MAPK8 ITGB3BP NGFR UBB FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 FGF23 FGF22 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B REST SRF NR3C1 KCNIP3 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members PMEPA1 FURIN BAMBI CER1 STRAP TGFB1 UBE2M TGFBR1 TGFBR2 SKIL SKI CDK8 SMAD2 TIMP2 SMAD1 SMAD4 SMAD3 YBX1 SMURF2 SMAD7 BMP2 TIMP1 CCNT2 TCF3 ARRB1 ARRB2 TGIF1 TGIF2 CBL USP15 TFDP1 TFDP2 PPP1CC CHRDL1 FGF2 EP300 JUNB PARD6A CGN F11R RNF111 PRKCZ PARD3 FSTL1 FSTL3 BMP10 LTBP4 RARA ITGB3 ARHGEF18 LTBP3 ITGB1 LTBP1 ITGAV NEDD4L RXRA ACVRL1 BMPR2 AMHR2 GDF2 SMAD9 ITGB8 SMAD5 ITGB5 SERPINE1 GREM2 ZFYVE16 PARP1 BMPR1B BMPR1A HDAC1 APH1A RHOA ITGB6 PSENEN MAPK1 NCSTN APH1B PSEN2 PSEN1 ITGA8 INHBB INHBA PPP1R15A INHA MAPK3 TGFB2 ATP1B4 TGFB3 NCOR2 TNRC6C MTMR4 MOV10 MYCN NCOR1 AGO3 AGO4 SNW1 MYC SMURF1 SMAD6 AGO1 TGFBR3 AGO2 TNRC6A TNRC6B E2F4 FKBP1A PPM1A E2F5 UBE2D3 TCF12 XPO1 RBL1 STUB1 UBE2D1 TRIM33 CCNK CCNC UBA52 AMH CDKN2B GIPC1 NOG COL1A2 FST PPP1CA FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C CCNT1 PPP1CB UBB UBC SP1 UCHL5 CDK9 RPS27A MYOG NEDD8 MEN1 MYOD1 WWTR1 MYF6 TCF4 MYF5 HELLS KLF16 USP9X MMP14 MMP16 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 CYP11A1 FDX1 FDX2 FDXR STARD3 STARD3NL AKR1B1 TSPOAP1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 MDC1 WEE1 YWHAB YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 YWHAZ SFN PIAS4 BRCC3 CCNB1 CDC25C CDK1 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 H2BC26 RFC3 RFC4 H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 CHEK2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 TP53 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase CDK2 BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants FLT3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis GAD1 GAD2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 RAD50 XRCC1 MRE11 BRCA2 FEN1 PARP1 PARP2 LIG3 RBBP8 NBN POLQ VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation PRKCA KDR ITPR1 ITPR2 ITPR3 RASA1 NRAS PLCG1 PRKCZ PRKCB HRAS AHCYL1 PDPK1 SPHK1 CALM1 PRKCD DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism SFTPA2 ABCA3 SFTPD SLC34A2 SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I VWF TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35A1 SLC35B2 SLC35B4 SLC35D1 SLC35C1 SLC35D2 SLC35A2 SLC35A3 SLC35B3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3 CREB3L4 CREB3L1 CREB3L2 MBTPS1 CREB3L3 CREBRF DCSTAMP MBTPS2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism TCN2 CD320 CUBN CBLIF MMAB AMN MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA AREG EGF EGFR PLCG1 EREG BTC EPGN LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations UGT2B7 CYP51A1 GSTA3 GSTA1 COMT CES3 HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CES1 FMO3 MAT1A CYP2C9 NNMT CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 AHCY SLC35D1 SLC35D2 CYP2D6 CMBL ALDH3A1 FDXR POR SULT2A1 CES2 MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 GSTM4 PTGES3 CYP4F3 CYP4F8 GSTK1 CHAC1 PODXL2 CYP27B1 ABHD14B SULT1A1 CYP26A1 SULT1C2 CYP26B1 SULT1B1 CYP24A1 SULT1E1 CYP26C1 CYP21A2 CYP2R1 BPNT2 AHRR BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 CYP4F12 PTGS1 NR1H4 AHR HPGDS CYP4F22 CYP19A1 GSTO1 CYP4F11 AIP NAT1 NAT2 TBXAS1 GSTA2 PAOX SULT1A3 GLYATL3 GLYATL2 ALDH2 GLYATL1 ACSM2A CYP3A4 ACSM5 GLYAT ACSM4 UGT1A9 CYB5B CYP4B1 CYB5R3 CYP27A1 CYP39A1 GSTP1 AOC1 MTRR CYP7B1 CYP7A1 MAT2B CYP8B1 TPST2 TPST1 CYP46A1 RXRA DPEP2 DPEP1 ARNT2 TPMT AS3MT AKR1A1 GSTT2 GSTT1 CYP11A1 ESD GSTT2B UGT1A3 GSTM3 CYP2J2 GSTM2 GSTM1 GSTM5 NCOA1 GSTO2 MAT2A GSTA5 GSTA4 CYP11B2 ARNT CYP4A22 ACSM1 ACSM2B PTGIS MTR NCOA2 POMC GSTZ1 CYP11B1 ADH1C ADH1A UGT1A10 UXS1 ADH4 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 ALDH1A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT2B17 UGDH UGT2B4 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A S100A9 LCN2 S100A8 LTF S100A7 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis ST3GAL4 FUT2 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism SLC26A2 SLC22A5 ABCB4 SLCO1B1 SLCO1B3 ABCD4 SLC2A1 SLC2A2 ABCC2 LMBRD1 ABCB11 OXA1L KGD4 NDUFAB1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 B4GAT1 TIAM2 CHST3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 PTGES3 B3GAT3 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UBE2I PIP5K1C ERCC2 GBA1 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GLYATL3 TP53 GLYATL2 GLYATL1 ACSM2A GNG10 ACSM5 GLYAT ACSM4 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 XDH GNA14 GNG3 GNA15 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 NUP37 PPP1CC PPP2R1B PPP2R1A PPA2 PPA1 RPS27 PPP2R5D DCXR AKR1A1 SORD CRYL1 XYLB IPPK IPMK ISYNA1 IP6K1 INPP1 IP6K2 NUDT3 NUDT4 VAC14 PI4K2B INPP5B MTMR10 NUDT11 PPP2CA NUDT10 PPP2CB MTMR2 MTMR12 INPP5A PIK3C2A IMPA1 PPIP5K1 MTMR4 MTM1 PLCZ1 IMPA2 INPP4A PPIP5K2 FIG4 PLCE1 INPP4B IP6K3 PIKFYVE MIOX INPP5F PI4K2A ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 ATIC OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS CPT2 GLUD1 MID1IP1 GLUD2 KYAT1 SLC25A20 CPT1B RIMKLA GLUL RIMKLB CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ADH1C ADH1A ADH4 RDH11 SIRT5 AKR1C3 MARCKS PRPS2 ALDH1A1 PRPS1 RPEL1 IDI1 MVK RPE SHPK TM7SF2 PGLS PMVK PRPS1L1 SC5D FDFT1 RBKS FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 NQO1 GSTA3 GSTA1 RAP1A PRKACG PRKACA PRKACB RAPGEF3 COMT BLVRB RAPGEF4 BLVRA CA12 CA1 CA3 CA5B CA2 CA5A CA4 CA7 CA6 CA9 CA14 CA13 PLCG2 GCHFR CHRM3 GCH1 SPR PTS PCK2 SLC37A1 G6PC2 G6PC3 RPS4Y2 FBP1 RPS27L FBP2 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 RPS24 B3GNT7 RPS23 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 GCKR GCK HSP90AB1 LYPLA1 CYGB DDAH1 PRKAA2 PRKAG2 PODXL2 ABHD14B SULT1A1 STK11 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 PRKAB2 SULT1A4 SULT4A1 SULT1A2 SULT1C4 MAN2B2 MAN2C1 LBR OCRL NAT1 NAT2 GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM ITPA CAV1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 HAS2 SPAM1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L SEC23A ASPA B3GALT6 B4GALT7 PNMT DDC TH DBH SEC24B SEC24A IQGAP1 PLD1 SEC24D SEC24C WASL TCN2 CD320 FUT3 TPST2 TPST1 NOSIP B3GNT3 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 AS3MT RPL32 GSTT2 HSPG2 RPL31 GSTT1 RPLP1 RPL34 ESD RPL10L GSTT2B GSTM3 RPL8 GSTM2 RPL10A GSTM1 RPL6 GSTM5 RPL7 GSTO2 RPL7A RPL18A MAT2A ACAN RPL36AL GSTA5 GSTA4 LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD RPL23 RPL22 RPL13A RPL9P9 SUMO2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 GPI ADPGK RPL26L1 ENO1 ENO2 ENO3 MRI1 ENOPH1 HK2 BHMT2 ENO4 HK3 BHMT ADI1 TPI1 PGAM1 PGAM2 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 PGK2 PFKL ECSIT GNPDA1 GNPDA2 PFKM PFKP CREBBP SP1 GLYCTK KHK GPT MED19 MED18 MED11 KCNJ11 ABCC8 ADCY9 ADCY4 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 MED21 ADCY6 ADCY5 CDK19 MED13L PRKG2 HEMK2 PLA2G4A GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC ITPR1 CHAC2 GGT3P ITPR2 GGT1 ITPR3 GCLM LRP8 APOB NOS3 CES1 DHFR TK1 GNAS HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC RAB5A KPNB1 TYMS SLC3A2 NSDHL LIPI CYP2D6 LIPH FDXR SULT2A1 STARD3 SLC36A4 ACOT9 STARD4 STARD5 ACOT7 MECR STARD6 STARD7 RUFY1 CH25H PRKD3 SLC6A12 FDX1 SLC7A5 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 CYP2E1 FAR2 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 HSD11B1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA CYP4F3 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE TSPO SPHK2 PTGR1 PTGR2 CYP21A2 AHRR SLC46A1 SAMD8 ECHS1 SGMS1 SGMS2 PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIAS4 VDAC1 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 ABHD4 ABHD3 INSIG2 INSIG1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 PLA2G12A CERS5 GPX1 ALDH1L1 CERS6 DHFR2 GPX4 FAAH2 MTHFR TNFRSF21 MTHFS ALDH1L2 CERS1 MTHFD1 CERS2 MTHFD1L PPM1L MTHFD2 HSD17B14 TPTE MTHFD2L LRP2 SLC25A32 CYP3A4 FOLR2 HSD17B11 SLC19A1 AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 TPH2 MBOAT1 ASMT DDHD2 AANAT MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PITPNB GBE1 CPNE7 PYGM ECI1 GYS2 PHKG1 CPNE6 PHKG2 GDE1 GYG2 ACSM6 CPNE1 EPM2A CPNE3 AKR1E2 PHKA1 PTGDS MFSD2B PHKB PHKA2 ACAD11 ACAD10 PPP1R3C MFSD2A NHLRC1 SACM1L SLC51A SLC51B PISD GALT CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS PANK4 CBR1 PCYT1B PANK2 PCYT1A PANK3 PANK1 STARD3NL DCAKD PLAAT1 PLAAT3 COASY PLAAT2 PPCDC CYP7B1 SLC25A16 NUDT8 PLAAT5 VNN2 PLAAT4 PPCS AKR1D1 ENPP2 GDPD1 ENPP3 ALOX12B GDPD3 SLC25A42 GDPD5 AASDHPPT HSD17B7 CYP7A1 MAT2B ORMDL2 HSD17B1 ORMDL3 HSD17B2 SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CKMT2 CYP8B1 GAMT GATM ETNPPL PLEKHA8 SLC6A7 PNPLA3 SLC6A8 PNPLA6 CKM CKMT1B ACAA2 INPPL1 SLC6A11 MSMO1 CKB CYP46A1 PLB1 ENPP6 SBF1 HADH SBF2 TPTE2 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PLA2G10 GPD1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 CHAT PLD4 PLD6 PLD3 ALDH3B2 EBP CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 ACBD6 ARG2 ACBD4 DGAT2L6 SLC25A2 CRLS1 ACSF2 CYP11B2 PI4KA DEGS1 ALPI DEGS2 PI4KB TNFAIP8 CYP4A22 DBI PCTP ACOXL ABCC3 PLA2G4F ABCC1 PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L PPP1CA NME1 PPP1CB MLXIPL FECH ACADSB ADIPOR1 ADIPOR2 NADK2 ACAD8 TYR UCKL1 DCT UCK2 UCK1 PUDP TK2 TYRP1 SLC5A8 SLC26A11 SLC26A1 ACO1 PLCB4 GCGR GCG SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLC5A6 COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ADSL PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS ADRA2C ADRA2A MT-CO1 B4GALT1 TKT SCO2 KCNG2 MT-CO2 MT-CO3 PPARGC1A PPARGC1B KCNC2 MED16 MED15 MED17 MED12 KCNB1 MED14 MED13 MED10 KCNS3 MED27 MED26 SIRT3 ALDH2 MED23 MED25 MED24 MED20 PPARG PPARA PPARD MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 RORA L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ODC1 ATP5MK COX11 AMD1 ATP5MJ OAZ1 COX14 SAT1 OAZ2 NDUFV3 SRM NDUFV2 ATP5MG OAZ3 MED30 NDUFV1 AZIN2 ATP5MF AZIN1 MED31 AGMAT ATP5ME SMS COA3 COA1 GOT1 UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 G6PC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 DMGDH NDUFB7 NDUFB6 CHDH SARDH COX4I1 NDUFB5 COX4I2 NDUFB4 ALDH7A1 SYT5 NDUFB3 NDUFB2 MLX ETFDH ALDH4A1 NDUFB1 PRODH FOXRED1 PRODH2 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 ARNT NDUFA6 FAHD1 NDUFA3 RRM2B NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 CCNC COX7B COX7C CTSL CAD COX8A DHODH SREBF1 UMPS COX8C COX5B COX5A COX6C GPAM COX6A1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C SAMHD1 VDR ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 PPM1K AUH QDPR IVD IL4I1 HIBCH PCBD1 ASRGL1 GALM RRM2 HGD TAT FAH HPD CARM1 LALBA NOSTRIN PNPO AOX1 XYLT2 XYLT1 B4GALNT2 NAMPT B3GALT2 PIP4K2A B3GALT1 PIP4K2B PIP4K2C FAM20B FUT4 FUT6 FUT5 FUT7 MED1 FUT9 B3GALT5 GALK1 PXYLP1 MED8 B3GAT2 B3GAT1 GALE MED4 MED6 MED7 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD CGA NR1D1 PIP4P1 GCSH SNAP25 GUK1 PAH GCDH HYKK AADAT SLC25A21 CRYM AASS CDA DHTKD1 CYB5A SLC23A2 SLC23A1 CIAO3 CIAO1 AFMID RIDA UROD NUDT13 NUDT12 NDOR1 NADK GNS UROS ALAS2 BCAT1 CYB5R3 DCTPP1 BCAT2 SLC45A2 ALDH6A1 KYAT3 ESRRA HIBADH THTPA NMRK2 TCN1 NMRK1 KMO PYGB COX10 NAXE PYGL PPOX CDK8 RRM1 NAXD HMBS ACMSD LHPP MMS19 MOCS2 MOCS3 RNLS TPK1 MOCOS CIAO2B SLC22A13 GSTP1 DTYMK HAAO GRHPR AOC1 TDO2 AGL IDO2 IDO1 QPRT SLC25A44 SLC25A51 SLC25A19 SLC25A28 SLC25A37 NUBP1 NUBP2 ENTPD2 GPX2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 GYG1 CD38 CPOX GPHN GLRX5 GLDC HOGA1 SLC19A3 SLC19A2 OCA2 SMARCD3 NMNAT3 NMNAT2 NMNAT1 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMT GLRX NADSYN1 NME3 NME4 ALAD DCTD TXNRD1 CMPK1 PGM2 KYNU CTPS2 CTPS1 PGM1 TTR COX7A2L TXN DERA BST1 VNN1 ARNT2 NFYA NFYB NFYC MANBA GAA NME2 BMAL1 CD44 COXFA4 COX7A2 COX7A1 SLC2A3 MAN2B1 POMC NAPRT PDXK GALNS UGT1A10 UXS1 UGT2B28 SLC9A1 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 BCKDK UGT2B15 BCKDHA UGT2B17 BCKDHB UGDH DBT UGT2B4 DLD UGT2B7 LDLRAP1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL LDLR GPIHBP1 MBTPS1 APOC3 ALB MBTPS2 FLAD1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 SERINC4 UCP1 HSD17B10 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA ALOX12 PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 PLCB3 CACNB2 PLCB1 PLCB2 CACNA1D DNM2 TPH1 EPRS1 TRMT112 CYP4F12 RAN ABCC5 ABCB7 NT5E ENTPD1 ENTPD5 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP RBP4 RBP1 LRAT ABO MMAB MTRR RTEL1 CBLIF MMACHC MMADHC INPP5E MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 LPIN2 MGLL LPIN3 PDK4 PEX11A CD36 NCOA2 NCOA6 NCOA3 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 PLIN2 BCO1 VKORC1 AKR1B10 CLPS PNPLA2 RBP2 LRP10 LRP12 PNLIP ADIPOQ DSEL DSE UST CHST15 ZDHHC21 ACSS3 AGPAT2 THRSP GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH TKFC ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 FMO3 NMT1 HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 SEPSECS QARS1 PSTK MARS1 INMT DARS1 SARS1 EEF1E1 AHCY KARS1 CBS IARS1 GNMT CTH SCLY CMBL ALDH3A1 POR CES2 BMX MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 APIP CYP2B6 EPHX1 CYP2S1 CYP4V2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 DUOX2 TSHB INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RPLP0 HSPA9 GSTO1 AIP TALDO1 MTAP GSTA2 AHCYL1 SULT1A3 MMAA MMUT PGD MCCC2 BTD PC PCCA HLCS MCCC1 PCCB ACACB FFAR1 TMLHE SHMT1 BBOX1 ALDH9A1 MTMR1 SHMT2 HMOX2 LETM1 GYS1 RHCE RHD PIK3CB NDUFA5 PTPN13 VAPB PIK3CA PIK3R3 PIK3C3 TRIB3 PIK3R4 PIK3R2 PIK3R1 STXBP1 INS THEM4 CACNB3 PLD2 CACNA1A ACBD5 CACNA1E ACSM1 ACSM2B MTR CALM1 NDUFS3 WDR26 PDHB RMND5B LDHA MPST TSTD1 MAEA SQOR PDPR GADL1 RMND5A SUOX ME1 NEK1 ADO CSAD PDK3 TXN2 DLAT TST PDK2 PDK1 ETHE1 PDHX SLC25A10 PDHA2 CDO1 PDHA1 GLP1R SIRT4 BRIP1 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 CYP11B1 HMMR SEM1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC PRSS3 PDZD11 PLA2G2A HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 CHPF OLAH CHSY1 ELOVL4 CHST11 ACSL1 ELOVL5 CHST12 CHSY3 ELOVL2 CHST13 SCD5 CSGALNACT1 ELOVL3 CHST7 ACSL6 CHPF2 ACSL5 CSGALNACT2 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 GSTK1 ASNS PHYH ACOT8 CHAC1 PIPOX BCS1L GNPAT ACOT2 STX1A ACOT4 COX19 COX17 ATP5MC1 PSMD8 HMOX1 PSMD6 HACL1 PSMD7 HAO1 CYC1 DECR2 PSMD2 HAO2 PSMD3 AKT1 PSMD1 NUP214 EPHX2 IDH1 PRKCA CS PSMA5 PSMA6 COQ2 PSMA3 AMACR PSMA4 DAO PSMA1 PXMP2 PSMA2 ACO2 MAPKAPK2 CROT UBA52 HSCB PSMD12 PSMD11 CACNA1C PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 TIMM21 BAAT UBB PSMB2 SLC25A17 ACOX2 PSMB3 UBC PSMB1 EHHADH AGPS PRSS1 RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PHYKPL ADRM1 CTRB2 PAOX CTRB1 NDUFB8 PSMC5 TAFAZZIN PSMC6 PSMC3 PSMC4 HSD17B4 PSMC1 PSMC2 DDO HMGCL ATP5F1A ATP5F1B IDH3G CYCS SRD5A3 NUDT7 VAPA CRAT IDUA NCAN HEXB HEXA LTC4S BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB HADHB HADHA ACADVL HSP90AA1 CYP17A1 PLCG1 NMT2 POLD1 EP300 RXRA HDAC3 GPS2 RXRB UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 NR1H2 NR1H3 NCOR2 NCOR1 TBL1XR1 FABP6 APOC2 PLIN1 HK1 AKAP5 GNAI1 GNAI2 MVD ST6GALNAC5 ST6GALNAC6 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 NEU1 CHD9 ST3GAL4 SLC17A5 ST8SIA5 ST3GAL5 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 TGS1 CTSA APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins OCLN DSG1 TJP2 DSG2 DSG3 CTNNB1 TJP1 PKP1 CDH1 DSP CASP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model SLC25A14 UCP1 UCP3 SLC25A27 UCP2 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm FOXF1 SHH IHH BMP4 GATA4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis CLTC CLTB CLTA DNASE2 CLVS2 CLVS1 ARF1 CTSZ BLOC1S1 GNS TXNDC5 HGS DNM2 AP4S1 AP4M1 AP1G2 DNAJC6 AP1G1 AP1S2 AP1S1 AP1S3 VAMP7 SH3GL2 AP1M2 HSPA8 AP1M1 VAMP2 AP1B1 VAMP8 APP CHMP2A AP4E1 M6PR ARRB1 AP4B1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SGTA STX5 STX1A VAPA VAMP2 BAG6 SERP1 SEC61G GET1 APP OTOF SEC61B HMOX1 GET3 EMD GET4 CAMLG UBL4A PRNP DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions ZNF217 STRAP HEYL ANGPTL4 TCF3 TGIF2 EED POMT2 POMT1 RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ANG RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ EML4 SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 NEK9 ZWINT NEK6 NEK7 KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 BTK GNGT1 GNG8 GNGT2 GNG10 GNG12 GNG11 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 ADORA2B GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B IL6 PRKAR1A PRKAR2A PRKX GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 DHFR TK1 RB1 CDKN1B RRM2 E2F1 RBBP4 SKP2 CABLES1 FBXO5 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 SOS1 YAP1 HBEGF GFAP SPARC SHC1 PIK3R1 NRAS APH1A ITCH PSENEN NCSTN APH1B PSEN2 PSEN1 GABRG3 APOE GABRG2 GABRB3 GABRB2 GABRB1 NCOR1 CXCL12 ESR1 WWOX ADAM17 SRC NRG1 DLG4 STAT5A NEDD4 GABRQ EGF EGFR GABRA1 UBA52 STMN1 WWP1 ADAP1 CSN2 UBB UBC RPS27A MXD4 HRAS S100B TAB2 EREG NRG3 PIK3CA PGR NRG4 NRG2 BTC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly COL17A1 ITGB4 LAMB3 CD151 ITGA6 PLEC DST LAMA3 LAMC2 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm OSR1 FGF2 FOXC2 FOXC1 BMP4 PAX8 PAX2 LHX1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 GSTZ1 PDP2 DLD FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway CENPX UBA52 MUS81 WDR48 SLX4 EME1 EME2 SLX1B FANCI UBB ATRIP FANCC UBC FANCD2 RPS27A DCLRE1B DCLRE1A FAAP100 UBE2T FAAP24 USP1 POLN FAAP20 FAN1 FANCM RPA1 FANCL FANCA RPA2 FANCB FANCE FANCG FANCF RPA3 ERCC4 ERCC1 ATR CENPS UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HBEGF HSP90AA1 CD9 HSP90AB1 TXNRD1 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family MUC15 MUC13 MUCL1 LYN MUC3A MUC5AC CLEC4C MUC3B CLEC4D MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 CLEC10A CLEC4A CLEC4E CLEC6A SYK FYN PLCG2 MUC12 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs CDC42 CTTN FLNA PPP1R12A PAK1 PAK3 LIMK1 RAC1 MYL12B MYL6 MYH9 MYLK MYH14 MYH11 MYH10 MYL9 NF2 PAK2 PPP1R12B PPP1CB CALM1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 DOCK3 RAC1 NTRK2 BDNF DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD SLC35D1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery SNRPD2 SNRPD1 SNRPD3 SNRPB SMN2 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 SNRPG RPS25 RPS28 RPS29 RPS20 FAU SNRPE RPS21 RPS24 RPS27 RPS23 SNRPF G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase E2F1 CDK2 E2F3 CCNA2 CCNA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes FMO3 CYP17A1 CYP4F22 CYP19A1 TPMT CYP7B1 MAT1A CYP11A1 CYP2U1 CYP1B1 CYP27A1 CYP11B2 AHCY CYP27B1 CYP11B1 TBXAS1 SLC35D1 CYP26B1 GSS OPLAH CYP24A1 CYP26C1 CYP2R1 CYP21A2 GCLC GGT1 GCLM FDXR ACY1 MAOA UGT1A4 FDX1 FDX2 UGT1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1 LHPP SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK PIK3CB SOS1 ALKAL2 ALKAL1 LTK TNK2 PIK3R2 PIK3R1 GRB2 PIK3CA IRS1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 GNG13 CDC42 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 ARHGEF6 GNG7 GNGT1 GNG8 PAK1 GNGT2 GNG10 GNG12 GNG11 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly NDOR1 RTEL1 POLD1 ABCB7 MMS19 BRIP1 ERCC2 CIAO3 CIAO1 NUBP1 NUBP2 CIAO2B VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways RELA NPM1 ITCH NR3C1 IRAK1 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 MED4 MED6 MED7 UBE2N VAV1 MAPKAP1 NEDD4L C4BPA C4BPB PTGES3 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB TAF7L FEN1 UBE2I SUMO1 C1QA C1S ELOB ELOC RBX1 VHL RNMT CCNH POLR2A ISCU POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 KPNA7 KPNA4 KPNA5 GBP1 KPNA3 CDK8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 PPP1CC PML DYNC1LI1 DYNC1LI2 RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 CD33 CHUK TJP1 DYNC1I2 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 BRD4 RPS18 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A TLR6 IKBKE IRF7 RAN NEK2 PDIA3 TUBB VPS36 VPS25 CBX1 SNF8 CHMP1A UBE2V1 CUL5 UBA7 UBA6 UBA5 UBR4 PAK2 IGF1R CAV1 UBA3 UBA1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A FXYD4 FXYD3 HYOU1 FXYD2 FXYD1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 NRP1 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 ARID4B SAP30 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD TAB3 TAB2 NFKBIB ELK1 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 SAP30L IFNA17 BAG2 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 PARP8 TUFM GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 DNAJC10 NMT1 VPS33B RIPK3 RAB5A KPNB1 TLR4 BCAP31 FNTA CHMP4C CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TAF9B KPNA2 MAP3K7 H2AC1 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA SCAP MAVS TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 CRNKL1 CDC40 ATP6V1H DHX9 CSTF3 CSTF2 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 DOCK2 CAMK2G HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 EFTUD2 PPP1CB CWC22 PAPOLA TXNL4A SNRPN ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 ACOT2 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B HSP90AA1 EGFR RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 CTSL ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 ATP7A ATP8B4 ATP8B3 ATP8B2 CAMK2B ATP8B1 SRI ATP4B CAMK2D ATP4A FXYD4 FXYD3 CAMK2A FXYD2 FXYD1 FXYD7 FXYD6 ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP7B CALM1 CAMK2G PDZD11 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants FLT3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GNAI3 GNAI1 GNAI2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development CLTB YAP1 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 MAG TEAD1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 POU3F1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 MBP ADGRV1 TYROBP DOCK1 MPZ ADGRG6 HMGCR ERBB2 PRX PMP22 SOX10 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM POU3F2 ANK1 SEM1 FYN CLTC CYP51A1 CLTA SREBF2 AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA2 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 SCD5 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 NAB1 MSI1 COL6A2 NAB2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 EGR2 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 DRP2 ROCK1 ROCK2 CNTN1 UTRN DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 HDAC2 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 WWTR1 YES1 SMARCA4 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CD4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism SLC26A2 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC CUBN AMN ABCD4 LMBRD1 GSS OPLAH GCLC GGT1 GCLM ACY1 SFTPD PPM1K AUH IVD HIBCH FMO3 GALM ADAMTS13 MAT1A POMT2 CYP2U1 G6PC3 POMT1 CYP1B1 POMGNT1 B4GAT1 AHCY DAG1 SLC35D1 LARGE1 APRT PNP ACACA HPRT1 FDXR ADA MAOA GALK1 CHSY1 GALE PRELP CHST6 OMD FDX1 KERA FDX2 NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 ACAT1 SFTPA2 MGAT2 PAPSS2 MOGS SDC4 SDC2 SDC3 B3GAT3 CYP27B1 SGSH CYP26B1 CYP24A1 CYP26C1 CYP21A2 CYP2R1 NAGLU B4GALT1 MAN1B1 ECHS1 GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 IDH1 UBA52 CYP4F22 CYP19A1 UBB TALDO1 UBC TBXAS1 RPS27A MMAA MMUT SFTPC PAH SRD5A3 MCCC2 BTD PC GBE1 PCCA HLCS MCCC1 GYS2 PCCB GYG2 EPM2A GNS PPP1R3C NHLRC1 CYP27A1 GALT B3GALT6 SLC37A4 B4GALT7 MMAB IDUA NCAN HEXB HEXA BGN DCN BCAN MTRR VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB GYG1 CYP17A1 GYS1 CYP7B1 PGM1 TCN2 CD320 CBLIF MMACHC MMADHC MUC13 G6PC1 SFTPB SFTA3 CHST14 SFTPA1 TPMT DCXR HSPG2 CYP11A1 GAA ACAN CYP11B2 LUM AGRN FMOD ABCA3 GALNT12 SEMA5A DPAGT1 SPON2 SEMA5B SPON1 THSD7B MPI MTR ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 CSF2RB THSD7A CSF2RA ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 ADAMTS12 DPM1 DPM2 THSD1 POMC ALDOB DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 SI MUC1 LCT MUC2 ADAMTS19 HGSNAT GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 CYP11B1 NEU1 SSPOP KHK MUC5B MUC20 MUC21 GALNS LFNG ST3GAL3 MPDU1 CTSA NUS1 UGT1A4 PMM2 GFPT1 DOLK SLC34A2 UGT1A1 BCKDK BCKDHA BCKDHB MC2R DBT DLD SLC25A15 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling LIFR CRLF1 TYK2 IL6ST STAT3 CBL SOCS3 IL6R LIF IL11 OSM IL6 OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA STAT1 CTF1 PTPN11 CLCF1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling FGF18 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 SPRED2 SPRED1 FGFRL1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding CLTC CLTB FTH1 CLTA FTL CTSZ BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 GNS SNAPIN AP3S1 TPD52 CLINT1 DNM2 AP4S1 AP4M1 AP1G2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 M6PR GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 STX4 SNAP23 DNASE2 CLVS2 IGF2R CLVS1 DTNBP1 ARF1 GOLGB1 NAPA RAB5C GBF1 TGOLN2 AP3B1 TXNDC5 HGS OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 APP CHMP2A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NEDD4L SERPINE1 FURIN PARP1 HDAC1 MAPK1 SKIL MAPK3 ATP1B4 SKI CDK8 NCOR2 SMAD2 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC E2F4 CCNT2 PPM1A E2F5 UBE2D3 RBL1 TGIF1 UBE2D1 TGIF2 TRIM33 CCNK CCNC UBA52 CDKN2B COL1A2 CCNT1 TFDP1 TFDP2 UBB UBC SP1 RPS27A CDK9 EP300 JUNB RNF111 MEN1 WWTR1 USP9X BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT FKBP1A NFATC2 NFATC3 PPP3CA PPP3CB NFATC1 PPP3R1 CALM1 PPIA GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI3 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 MCRIP1 SNAI2 KMT5A TGIF2 EED RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB CANX MGAT1 PRKCSH MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SNAPC5 SNAPC1 SNAPC2 SNAPC3 CCNT2 SNAPC4 ZNF143 PCF11 POU2F1 POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E SRRT POLR2F POLR2G POLR2H TAF9 POLR2I POLR2J POLR2K POLR2L TAF13 SUPT5H GTF2F1 TAF11 GTF2F2 ELL CDK7 CCNT1 TAF8 SUPT4H1 TAF6 TAF5 NCBP1 NCBP2 SP1 INTS1 INTS3 INTS2 CDK9 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 GTF2A1 ICE1 GTF2A2 ICE2 GTF2B SSU72 GTF2E1 GTF2E2 NABP2 NABP1 PHAX ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB1 DEFB104B DEFB109B DEFB136 DEFB135 DEFB134 CCR6 DEFB133 DEFB132 DEFB108B DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion CACNA1D GNG13 GNB2 GNAQ KCNJ11 GNB1 ABCC8 GNB4 GNB3 STXBP1 INS GNB5 ADCY8 GNGT1 ADCY6 ADCY5 GNGT2 RAP1A SLC2A1 PRKACG SLC2A2 PRKACA ADRA2C PRKACB RAPGEF3 SYT5 FFAR1 ADRA2A RAPGEF4 CACNB3 GNA14 CACNA1A CACNA1E STX1A GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 KCNG2 AKAP5 GNAI1 GNAI2 PRKCA IQGAP1 CD36 SNAP25 GNAS KCNC2 GCG CACNA1C CHRM3 GLP1R KCNB1 KCNS3 VAMP2 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CACNA2D2 MARCKS CACNB2 PLCB3 PLCB1 PLCB2 GNG10 ACSL4 ACSL3 GNG12 GNG11 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones HSPA5 MBTPS1 ATF6B MBTPS2 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM6 IRF1 NCAM1 TRIM5 IRF2 TRIM2 TRIM3 GBP1 CIITA HLA-H TRIM68 TRIM62 HLA-B TRIM46 HLA-C TRIM48 TRIM45 HLA-F TRIM35 HLA-G TRIM38 HLA-E OAS2 TRIM31 TRIM34 MAPK1 FCGR1BP IFI30 RAF1 TRIM29 TRIM26 TRIM22 MAPK3 MT2A TRIM17 SOCS1 PTPN1 IFNGR1 TRIM14 VCAM1 IFNGR2 TRIM10 PTPN11 SP100 CD44 MID1 YBX1 IRF8 B2M IRF6 IRF3 IRF9 SMAD7 CAMK2B PIAS1 HLA-A CAMK2D SUMO1 TRIM21 GBP5 CAMK2A GBP2 GBP6 GBP4 GBP3 TRIM25 IRF7 FCGR1A CAMK2G PRKCD IFNG PTAFR OASL OAS1 OAS3 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 JAK2 HLA-DRB4 JAK1 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 PML HLA-DQB1 ICAM1 SOCS3 PTPN6 IRF4 IRF5 GBP7 TRIM8 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) ATP6V0D1 SRPRB TPP1 PREB CXXC1 CXCL8 HDGF PPP2R5B KDELR3 SHC1 CREB3L3 ADD1 DCTN1 HSPA5 NFYA NFYB NFYC ATF6 CEBPB HERPUD1 CEBPG CCL2 ASNS SEC31A EIF2S2 EIF2S1 ERN1 EIF2S3 DDIT3 CREB3 CREB3L4 CREB3L1 ATF3 CREB3L2 ATF4 CALR EXTL2 MBTPS1 CREBRF DCSTAMP ATF6B MBTPS2 PLA2G4B EXTL3 HYOU1 KHSRP GSK3A EIF2AK3 DIS3 ACADVL PDIA6 DNAJB11 DCP2 SERP1 PARN WFS1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 TLN1 EXOSC8 DNAJC3 EXOSC3 EXOSC2 EXOSC1 CUL7 FKBP14 IGFBP1 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 HSP90B1 CTDSP2 SRPRA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema KLKB1 F2 F12 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A CPSF4 CHTOP CPSF7 CPSF1 FUS ALYREF CPSF3 CPSF2 SRRM1 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 CDC40 DDX39A ZC3H11A SARNP DHX9 DDX39B CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 UPF3B MAGOHB HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SLU7 SF3B4 FYTTD1 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 CASC3 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG13 GNB2 GNB1 GRIK3 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) YAP1 CREBBP DPPA4 DPPA2 LEUTX KDM4E EP300 TPRX1 TPRX2 ZSCAN4 TEAD4 TUT7 TUT4 DUX4 TP53 TPRXL DUXA DUXB AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC NQO1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 PPM1K SDSL AUH IVD QDPR SERINC2 IL4I1 PSPH HIBCH SERINC5 PCBD1 ASRGL1 SERINC4 HNMT SEPHS2 KGD4 RARS1 SECISBP2 MAT1A LARS1 HGD NNMT TAT FAH EEFSEC HPD AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 RPS17 SARS1 HSD17B10 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT SLC3A2 RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 SLC36A4 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 APIP RPS20 SLC6A12 HAL FAU RPS21 CARNMT1 RPS24 SLC7A5 UROC1 RPS23 AMDHD1 HDC CARNS1 FTCD CGA FMO1 ACAT1 PAPSS2 PAPSS1 ASNS TPH1 PIPOX EPRS1 ECHS1 PSMD8 PSMD6 PSMD7 HAO1 PSMD2 PSMD3 PSMD1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO GCSH PSMA5 IYD PSMA6 DUOXA1 PSMA3 DUOXA2 PSMA4 DUOX2 PSMA1 DAO TSHB PXMP2 PSMA2 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A MTAP SLC25A12 AGXT PHYKPL SLC25A13 ADRM1 PAOX PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DDO TP53 CAV1 GCDH PAH HYKK TPH2 AADAT ASMT SLC25A21 AANAT CRYM AASS DHTKD1 MCCC2 AFMID MCCC1 RIDA BCAT1 AGXT2 BCAT2 SLC45A2 ALDH6A1 KYAT3 HIBADH KMO OGDH FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA ACMSD TMLHE SHMT1 BBOX1 ALDH9A1 PNMT HAAO GRHPR DDC TDO2 TH IDO2 DBH IDO1 SLC25A44 MTRR DLST SLC44A1 GLDC HOGA1 OCA2 AMT TXNRD1 KYNU ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM OAZ3 AZIN2 AZIN1 AGMAT CKMT2 GAMT SMS GATM SLC6A7 GOT1 SLC6A8 CKM CKMT1B SLC6A11 CKB RPS27 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 DMGDH RPLP1 RPL34 CHDH RPL10L SARDH RPL8 ALDH7A1 RPL10A RPL6 RPL7 ARG2 ALDH4A1 PRODH SLC25A2 RPL7A RPL18A PRODH2 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 MTR RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MRI1 ENOPH1 BHMT2 BHMT OAT ADI1 GLS2 GOT2 PYCR1 MPST TSTD1 PYCR2 PYCR3 SQOR GLS GADL1 GLUD1 SUOX GLUD2 ADO KYAT1 CSAD RIMKLA TXN2 GLUL TST ETHE1 RIMKLB SLC25A10 CDO1 GSTZ1 ACADSB ACAD8 TYR SIRT5 DCT SEM1 TYRP1 GPT BCKDK BCKDHA BCKDHB DBT DLD SLC25A15 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) OPN1MW OPN1LW DHRS3 OPN1SW RBP3 AWAT2 RLBP1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle CS ISCA2 ISCA1 ACO2 FXN ACAT1 LYRM4 SDHAF2 SDHAF3 SDHAF1 CSKMT SDHAF4 IDH2 SDHC SDHD SIRT3 SDHA SDHB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation MAPKAPK3 MAP3K7 IRAK1 UBE2V1 MAPKAPK2 TRAF6 MAPK14 MAPK11 IRAK2 TAB1 TAB3 TAB2 NOD1 MAP2K6 NOD2 UBE2N IKBKG MAP2K3 RIPK2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs HACD1 ACSBG1 TECR HSD17B3 SLC27A3 HSD17B12 ACSBG2 HACD3 HACD2 HACD4 ELOVL1 ELOVL4 ACSL1 ELOVL5 ELOVL2 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER PCNA PARP1 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 DDB2 POLD2 POLE RFC2 RFC1 PARP2 RPA1 CHD1L RPA2 DDB1 XPA POLE4 CUL4A RPA3 RBX1 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 GCN1 RPS19 RPS18 EIF2AK4 RPS3 RPS2 RPS11 IMPACT RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 TRIB3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A CEBPB RPL6 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPL37 ATF3 ATF4 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking WNT5B WNT5A PORCN WNT7B WNT16 WNT1 WNT7A SNX3 WNT3A WNT9A WNT3 WNT8A WNT8B WNT10B WNT9B WNT6 WNT4 WNT2 WNT2B WNT10A VPS29 WNT11 VPS35 WLS VPS26A TMED5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB2 VDAC1 MAIP1 PARL AFG3L2 LETM1 SMDT1 YME1L1 PMPCB PMPCA MICU3 AKAP1 MICU2 MICU1 MCU PHB1 SLC8B1 SLC8A3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PDE6G GNB1 GNGT1 APOA2 APOA1 APOA4 HSPG2 APOE SDC4 SDC2 SDC3 LPL RBP4 RDH12 OPN1LW RBP1 LRAT LDLR AGRN STRA6 GPIHBP1 GPC1 APOC3 APOC2 RDH5 GPC3 RLBP1 LRP8 GPC2 GPC5 GPC4 GPC6 OPN1MW APOB RPE65 SDC1 CALM1 PRKCA RDH8 OPN1SW GUCY2D GUCA1B GUCA1A GUCA1C LRP1 GUCY2F NMT1 RETSAT GRK1 APOM GRK7 FNTB RHO BCO2 CNGA1 BCO1 GNAT1 RCVRN AKR1B10 CAMKMT CLPS RBP2 RGS9BP SLC24A1 SAG LRP10 NMT2 LRP12 RBP3 PPEF1 PNLIP HSD17B6 METAP1 METAP2 CNGB1 HSD17B1 FNTA AKR1C1 TTR RDH11 RDH10 ABCA4 AKR1C4 RDH16 AKR1C3 SDR9C7 DHRS3 MYO7A DHRS9 PRKCQ LRP2 PLB1 CYP4V2 AWAT2 PDE6B PDE6A CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CALM1 CAMK2G ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS PLA2G2D OSBPL10 PLA2G2E MBOAT1 PLA1A PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLAAT3 PLA2G2A OSBPL8 PLA2G1B OSBPL5 LPCAT4 LPCAT3 PLA2G2F PLA2G4A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS SOS1 HBEGF TGFA AREG EGF EGFR NRAS EREG BTC EPGN DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 MAP3K7 IRAK1 UBE2V1 TRAF6 MAPK9 IRAK2 TAB1 MAP2K7 MAPK10 MAPK8 TAB3 TAB2 NOD1 NOD2 UBE2N IKBKG RIPK2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 RUVBL1 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 POLR2A POLR2B POLR2C POLR2D NHP2 POLR2E POLR2F ANKRD28 POLR2G NOP10 POLR2H POLR2I POLR2J POLR2K PPP6C POLR2L PPP6R3 BLM RTEL1 CHTF8 DAXX ATRX WRN PRIM2 PRIM1 H2AX POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC2 TERT RFC1 H3-3B STN1 RPA1 TEN1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ RPA3 H2BC15 CCNA2 CCNA1 H2BC11 DNA2 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BRD7 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SMARCE1 ACTB ARID2 PBRM1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 BCL2L1 NLRP1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors PRKCA TSPAN7 AP2A1 GRIA1 GRIA2 PRKCB GRIP1 NSF PICK1 PRKCG GRIP2 GRIA3 GRIA4 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia F9 F10 F8 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 RPS6KA2 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle ARHGAP26 AKAP12 HINT2 VANGL1 ARHGAP32 PIK3R2 PIK3R1 RHOD ESYT1 ACTN1 LMNB1 TOR1AIP1 ARHGAP12 DBN1 CPNE8 STEAP3 ANKFY1 GOLGA8R MOSPD2 ADD3 ARHGAP1 SLC4A7 ARHGAP39 ARHGAP5 ARHGAP35 FILIP1 STBD1 EMD LBR TMPO VRK2 PLXNA1 LEMD3 DEPDC1B PLXNB1 CAPZB VAMP3 EFHD2 RAB7A ARHGAP17 ARHGAP21 PAK6 LMAN1 WHAMM PGRMC2 PAK5 RACGAP1 VAPB DIAPH1 DIAPH3 CAV1 MCAM CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway RELA MALT1 CASP8 NFKB1 IL1B PYCARD INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLST DLD SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function CDH24 ADAM33 ADAM19 CTNNB1 CDH11 JUP ANGPTL4 CTNND1 CDH8 CTNNA1 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance APOA1 HDLBP CUBN AMN MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase LMNB1 NCAPG2 SMC4 SMC2 NCAPH2 NCAPD3 MCPH1 NUP205 POM121 NUP107 NUP188 KMT5A AAAS NUP160 POM121C ARPP19 NUP42 NUP85 TPR ENSA NUP62 BANF1 NUP88 USO1 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB2A NUP155 NUP133 RB1 NUP210 VRK1 LEMD2 NUP153 NUP93 NUMA1 NUP50 NUP35 NUP54 RAB1A RAB1B GOLGA2 NUP37 BLZF1 PPP2R1B H2AX CNEP1R1 PPP2R1A H2AB1 MASTL H2AC19 GORASP2 H2BC26 GORASP1 H2AC14 PPP2R2D H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 MAPK1 PPP2CA PPP2CB LPIN1 LPIN2 LPIN3 NUP214 PRKCA PLK1 CCNB1 CDK1 SET EMD LEMD3 CCNB2 NEK9 NEK6 NEK7 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency OTC TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes PCNA PLK3 CDKN1A PRMT1 PLAGL1 NPM1 RGCC PLK2 CDK2 BTG2 CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 E2F4 CNOT9 CNOT11 E2F7 E2F8 RBL2 ZNF385A RBL1 SFN CCNB1 CDC25C CDKN1B AURKA ARID3A CDK1 BAX E2F1 CARM1 TFDP1 CCNE2 TFDP2 CCNE1 CPAP PCBP4 EP300 CNOT6L CCNA2 TP53 CCNA1 GADD45A CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CDC6 ORC5 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 UBE2W H2BC3 PEX14 H2BC1 USP7 HLA-B USP5 UBA1 RNF20 UBE2K CDC34 VCP UBE2J2 UBE2Q2 UBE2R2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA UBE2G1 UBE2G2 UBE2C CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS UBE2S WAC UBA52 PRKDC CTR9 RTF1 BCL10 UBE2Z TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 UBE2E3 PEX2 UBB UCHL3 UBC RPS27A UBE2T OTULIN UBA6 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP9X H2BC11 UBE2H UBE2B UBE2N RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 PAX5 ELF1 ELF2 CBFB BLK HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly APOA1 PRKACG A2M PRKACA PRKACB ABCA1 ZDHHC8 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 SOS1 PIK3R1 NRAS FGF20 MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 PPP2CA FGF18 PPP2CB FGF10 PTBP1 HNRNPM HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 BRAF UBB PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling SOS1 STAT5A STAT5B CBL PIK3R1 NRAS UBA52 CDKN1B GRAP2 PTPRJ CSK BCL2L11 FLT3 UBB PTPN11 UBC RPS27A AKT2 GRB10 HCK SYK HRAS LCK FYN SLA ABL2 SLA2 SOCS2 SOCS6 FOXO3 SH2B3 FLT3LG AKT1 GAB2 PIK3CA AKT3 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions HHIP BOC GAS1 SHH IHH DHH CDON PTCH1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle TRAK1 TRAK2 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol RXRA NCOA2 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 HSD3B7 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) LTC4S PTGR1 HPGD ALOX5AP ALOX12 ALOX5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 FCGR1BP PSMD13 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CD207 MRC2 ADRM1 PSME2 MRC1 PSMC5 PSMC6 SEM1 PSMC3 PSMB10 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 FCGR1A PSMD1 PSMB8 PSMB9 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing FURIN PCSK6 NGF PCSK5 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases ARSB ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD STS ARSA SUMF2 SUMF1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD GCLC GCLM PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PIP5K1C CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 DISEASE%REACTOME%R-HSA-1643685.19 Disease SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L SLC5A1 SLC5A2 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 RNF185 SLC26A3 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 EXOC1 GBF1 POMT2 CYP2U1 POMT1 CYP1B1 POMGNT1 B4GAT1 DAG1 LARGE1 FGFR2 OGG1 RAC1 VAV3 UBE2N VAV1 VAV2 CHST3 ACAT1 DCTN1 PTGES3 MAPK8 BCL2L11 DNAJA2 FKBP4 HSPA1B BAD IFNGR1 IFNGR2 B3GAT3 IKBKB SQSTM1 CYP27B1 MYD88 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FEN1 UBE2I SUMO1 UBE2D2 ELOB ELOC RBX1 VHL RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B TP53 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 ACTG1 PPP1CC PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DVL1 DVL2 DVL3 RPS27 ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CARS1 DYNLL1 RANGAP1 DYNLL2 EEF1G DCXR CHUK DYNC1I2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 TAOK1 TFG MPRIP FGFR1OP2 SND1 ZC3HAV1 EIF2AK3 NOX4 ATIC DUSP8 DUSP9 MRAS KDR FAM114A2 PORCN MCL1 QKI NF1 KIAA1549 DUSP10 ESRP1 BIRC6 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 AGTRAP AP3B1 SHOC2 AGGF1 NFKB2 CPSF6 SI TENT4A LCT SPRED3 CTDP1 SPRED2 ELL SPRED1 CCNT1 MYO18A SUPT4H1 ELOA LRRFIP1 NELFB KANK1 RRBP1 ETV6 WDCP NELFCD NELFA FAM131B GOLGA4 NELFE BIN2 STRN SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 LFNG JAG1 DLL1 SKP1 CUL1 NTRK3 NTF3 NEURL1B HES5 MIB2 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 RAF1 IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 JAK3 SIGMAR1 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 G6PC3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X RPS15 IGLV3-25 RPS14 IGLV3-27 IGKC RPS17 IGKV1-39 RPS15A RPS16 IGLV3-21 IGKV1-33 RPS19 RPS18 BRD4 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 RPS10 STAT2 RPS13 IGLC6 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 UBE2L6 RPS24 HERC5 RPS23 OGN NOTCH2 NOTCH3 NOTCH1 NOTCH4 HBEGF GCKR GCK HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E SFTPA2 RNF213 ATG7 SEC31A RPTOR CALR MLST8 EIF4E TSC2 MRC1 GRSF1 MTOR FKBP1A TLR6 AKT1S1 CYFIP1 NCKAP1 BRK1 PDIA3 S100A1 VPS36 CYBA VPS25 CBX1 SNF8 BCR CHMP1A LMO7 RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 NCKAP1L WASF1 PAK2 WASF2 CAV1 ERBIN BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 TGFB1 TGFBR1 TGFBR2 LMNB1 TIRAP SEC23A B3GALT6 B4GALT7 WIPF1 WIPF2 WIPF3 FCGR1A SEC24B SEC24A IQGAP1 MAP3K11 SEC24D SEC24C DUSP16 FGFR1 TMPRSS2 WASL SRPK2 GALNT1 AXL TCN2 CD320 RCC1 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 TPST2 TPST1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B MASP1 XRCC6 XRCC4 XRCC5 LIG4 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A ACAN RPL36AL LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 HDAC4 RPL27 HDAC2 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 AMER1 RPL35A RPL23A GSK3B CSNK1A1 RPL3L AXIN1 RPL27A RPL22L1 APC RPL26L1 OPN1SW ENO1 CDC73 SKIC8 CTR9 RTF1 ALDOB LEO1 PAF1 HHAT SHH PGK1 DHH MAP2K4 CGAS CREBBP IRAK4 SP1 KHK TLR10 TLR5 AREG NFE2L2 BCL2L1 PTPN6 MAPK9 IRAK2 MAP2K7 CAMK4 NTF4 NTRK2 BDNF TAB3 TGFA TAB2 NFKBIB FOXO3 ELK1 PTK2 IFNA5 EREG IFNA4 BTC IFNA7 MC2R EPGN IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 KCNJ11 ARIH1 ABCC8 IFNA13 ABCC9 IFNA14 ADCY9 IFNA16 IFNA17 ADCY4 BAG2 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 FGR GGT5 GSS OPLAH GCLC ITPR1 ITPR2 GGT1 ITPR3 GCLM NOS2 P2RX7 EML4 P2RX4 GNAS VPS33B CORO1A HGS RAB5A KPNB1 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 UPK1A EPCAM FDXR SLC6A19 SLC36A2 SLC6A14 FDX1 FDX2 SLC7A7 SLC7A9 DUSP6 DUSP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B CYP21A2 STT3A STT3B MAN1B1 ECHS1 RETREG1 KEAP1 H2AC17 AGK H2AC12 TRIM25 CFTR STAM CYP4F22 CYP19A1 H2AC25 H2AC21 WDR48 IFIH1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TBXAS1 KAT2B PIK3CD KAT2A RNF135 TAF9B SFTPC MAP3K7 GBE1 GYS2 H2AC1 CDC25A GYG2 EPM2A STAM2 PPP1R3C VCP NHLRC1 CLINT1 TNKS FOXO4 GALT CYP27A1 NLRP3 RIPK1 SUDS3 SMAD2 SMAD4 SMAD3 ESR1 NFKBIA SCAP MAVS MDM2 TAB1 RIGI PTEN ARRB1 ARRB2 TRAF2 MERTK H2BC18 TRAF3 TRAF6 BECN1 CYP7B1 NOD1 NOD2 TNKS2 TAF10 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 AQR CRNKL1 DPEP2 CDC40 DPEP1 DHX9 CSTF3 CYP11A1 CSTF2 PCBP1 PCBP2 CSTF1 CYP11B2 DHX38 SYMPK RBM10 HNRNPL HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 IRF4 PRPF6 BCL2A1 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CPSF4 CPSF1 FUS ALYREF CPSF3 CCR5 CPSF2 CXCR4 CWC15 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 SLC35D1 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC27A4 KIT RBPJ B4GALT1 TXNIP SFN EZH2 CLDN1 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 PMS2 RICTOR MBD3 STAT1 GATAD2B GATAD2A CCNT2 CDC25C MSH2 KMT2D FOXO6 FOXO1 MED30 MED31 G6PC1 NFKB1 SFTPB SFTA3 SFTPA1 FASLG ITGA4 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A CCNK MUC5AC MUC3B CCNC ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 SH3GL3 EPS15 SH3GL2 SH3GL1 YES1 EEF2 CTSL SYVN1 RELA FZD8 ARPC1B ARPC1A NPM1 ITCH KLC1 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH ACTR3 ACTR2 NR3C1 TRAK1 KIF5B IRAK1 NCKIPSD ACY1 IL6 TAF4B YWHAE PRR5 DPY30 CHD4 PPM1K YWHAQ AUH IVD YWHAG HIBCH C4A YWHAH TBP EED GALM TAF9 TAF1L MTA2 TAF15 TAF12 TAF13 TAF11 SOD2 REST TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 MAML2 MAML1 DNAJC3 JUNB MED1 GALK1 MED8 GALE MED4 MED6 MED7 MAML3 MAPKAP1 NEDD4L PRDX2 PRDX1 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 PLK2 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 CD19 V2-8 V1-20 ASH2L V1-9 TAF7L V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QA C1S V4-6 V4-2 V4-1 ISCU SNAP25 SYT1 MSH3 PTPN12 NRBP1 TLR8 PAH KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ABL1 GNS CDK8 CDK5 WDR5 PYCARD CLEC5A GYG1 HDAC5 RAB5B RAB5C HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 RBBP5 RBBP7 TXNRD1 PML PGM1 HDAC10 TTR HDAC11 FCGR2A TWIST1 TXN PARP1 BST2 PRMT1 GP1BA HBB CD33 MLH1 TJP1 GAA CDK5R1 ESR2 NR4A1 CASP1 CD300A THBS1 ERBB2 HES1 DDX3X POMC PHB1 ARAF PEBP1 CSK JAK2 MARK3 HGSNAT FGB DYNLT1 BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 GALNS SLC9A6 SLC9A9 HCK SYK LCK UGT1A4 FYN F9 F10 GGCX PROS1 F2 GAS6 UGT1A1 BCKDK BCKDHA BCKDHB DBT DLD CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 CUBN AMN APOA1 SAR1B AP2S1 AP2B1 P4HB PRF1 ICOS STAT5A IL10RA ZC3HC1 CD3G BTRC ADAMTS13 MTA1 MTA3 FCGR3A MYH2 MYO10 MYO1C APRT PNP HPRT1 ADA PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX FZD5 FZD4 FZD6 PIM1 GBP2 GBP4 IKBKE IRF7 GP1BB F12 F11 GP5 GP9 KLKB1 BAG4 RAN SLC20A2 NEK2 WNT3A LRP5 KREMEN1 TUBB KREMEN2 DKK1 DKK2 LRP6 DKK4 AKAP9 ABCA4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 SUGT1 IGF1R CALM3 CALM2 CEP43 KDM7A ATP1B3 ATP1B2 ATP1B1 RBP4 RDH12 OPN1LW RBP1 NAPEPLD LRAT STRA6 FXYD4 MMAB FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 MTRR ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ANO10 CLCN6 SUN2 CBLIF MMACHC MMADHC NRG3 NRG4 NRG2 NTHL1 NEIL3 NEIL1 PIK3AP1 SIKE1 CSF2RB CSF2RA CD36 STAT5B GRB2 ARID4B CTBP2 CTBP1 SAP30 DNMT1 NCL CEBPD PDGFRB DNMT3B DNMT3A SAP30L RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 PARP9 IL17F IL17A PARP14 PARP8 GEMIN2 TUFM GEMIN4 CRK GEMIN5 GEMIN6 FMO3 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 FADD P4HA3 CD14 GSDMD DNAJC10 NMT1 GSDME C1QBP MAT1A RIPK3 IL18 IL1A IL1B TLR4 BCAP31 AHCY FNTA TICAM1 CHMP4C CHMP4B CHMP4A LY96 MLKL MAOA CHMP2B CHMP2A TRADD HMGB1 CASP8 CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 PAPSS2 PAPSS1 SDC4 SDC2 SDC3 SGSH NAGLU GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 SLC5A5 LYN PIK3CG PIK3R6 PIK3R5 BTK ARF1 NPLOC4 RPLP0 JAK1 IL10 MSN TALDO1 TYK2 PPIA ALK AHCYL1 LMNA KPNA2 MMAA MMUT MCCC2 BTD PC PCCA HLCS MCCC1 PCCB SPCS3 SPCS2 SPCS1 SEC11A SEC11C FOXM1 GNAZ CD163 RHBDF2 ADORA2B JAG2 ADAM17 RDH5 RLBP1 CYFIP2 GJA1 ZMYM2 FGFR3 GYS1 TPM4 TPM3 RNF43 KLB FLT3 IRS1 IRS2 EIF4E3 PIK3CB PPM1B FGF1 FGF2 FGF3 EIF4G3 FGF4 EIF4G2 FGF6 NCK1 FGF7 FGF9 AKT2 HRAS WASF3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 TLR9 PIK3C3 SOS1 RAC2 SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 NRAS FGF20 PPFIBP1 ATP6V1H MAPK1 FGF23 FGF22 ELMO2 MAPK3 PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 UNC93B1 TLR3 ABCA3 CAMK2B CAMK2D SRC CAMK2A NRG1 MTR ZAP70 CALM1 DOCK2 CAMK2G ANAPC15 DOCK1 ANAPC16 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CCNB1 CDC23 TRAT1 UBE2S RPS6KB2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 CYP11B1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 APP RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 HGF RAD9B RHNO1 ATR RAD9A CLIP1 SLC25A15 CPS1 ARG1 ASL NAGS KDELR1 SERPING1 ASS1 GCC2 NMRAL1 OTC PDGFB CLU HSPA5 CTSG COG1 TLR1 S100A9 S100A8 LTF TLR2 F8 CD9 S1PR1 GOLGA2 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST PRIM2 CUX1 CD4 PRIM1 POLA1 POLA2 ACACA TRIP11 PDGFRA GTF2A1 CHSY1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN TCF7L2 CDKN1A HDAC1 CDKN2A CDC25B CCND1 SIN3A CDK2 CTNNB1 MET CEBPB TNRC6C MOV10 ACOT2 STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 GRPEL1 YWHAB ELAVL1 PSMD8 HMOX1 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 IDH1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 PEX19 SRD5A3 C3 FURIN SLC67A1 CPSF7 ROCK1 ROCK2 CUL3 SRRM1 VIM HNRNPC RBMX AP1G1 ZBP1 AP1S2 AP1S1 AP1S3 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 HLA-A CD8B PACS1 IDUA ELMO1 NCAN CD28 HEXB OPN1MW HEXA BGN PALS1 DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB UVRAG MAP1LC3B TRIM27 HSP90AA1 EGF CBL EGFR CYP17A1 CDC37 PLCG1 CDKN1C RB1 CDKN1B CCND3 FZR1 FNTB CCND2 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 NMT2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX LIG1 MSH6 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 SFPQ IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 TAL1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ABCA1 ABCG8 ABCG5 NCOR2 NCOR1 TBL1XR1 DPAGT1 ST6GALNAC2 MPI HK1 GNAI3 GNAI1 GNAI2 ALG8 ST6GAL1 ALG9 ALG6 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 DHDDS DPM1 DPM2 DPM3 RFT1 ST6GALNAC3 ST6GALNAC4 SLC24A1 GNE NEU1 ST3GAL4 SLC17A5 ST3GAL1 AVP ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 SLC4A1 PMM2 ABCA12 SLC4A4 BSG GFPT1 SLC12A6 DOLK SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling TYK2 CANX IL6ST STAT4 JAK2 IL27RA EBI3 STAT3 IL12A JAK1 IL12RB2 STAT1 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions SLCO4A1 SLCO1A2 SLCO2B1 SLCO4C1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 AVP SLCO2A1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling JUN RELA RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 VAV3 PPP3CA PPP3CB PRKCQ PPP3R1 VAV1 UBE2N VAV2 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 NFATC2 V1-11 V1-16 V1-13 MAPK8 IKBKB V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 PSMD14 NFATC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 PSMC3 AHCYL1 PSMC4 PSMC1 PSMC2 PAK2 RASGRP4 MAP3K7 CARD11 MALT1 NFKBIA TAB1 TEC TRAF6 PLCG1 PIK3CB HRAS PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 NFKB1 NRAS MAPK1 CHUK FCER1G MAPK3 CALM1 UBE2D1 FCER1A LAT2 BCL10 MS4A2 TXK MAP2K4 FBXW11 MAPK9 SYK MAP2K7 SEM1 MAP3K1 FYN MAPK10 TAB3 SKP1 TAB2 FOS CUL1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NEDD4L TGIF1 UBE2D1 TGIF2 TRIM33 PARP1 HDAC1 UBA52 MAPK1 SKIL MAPK3 UBB ATP1B4 SKI UBC SMAD2 NCOR2 RPS27A SMAD4 SMAD3 NCOR1 SMURF2 SMAD7 SNW1 RNF111 WWTR1 PPM1A UBE2D3 USP9X RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF RUNX1 CCND1 BRD2 RUNX3 EP300 KRAS HDAC4 CBFB TGFB1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response MYH9 CD163 RHBDF2 FURIN ADAM17 IL10 MAPK14 PLK2 IL6 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle TFRC KIF14 KIDINS220 VANGL1 MUC13 PIK3R2 ARHGAP5 TMEM59 PIK3R1 ARHGAP35 TXNL1 ALDH3A2 PKP4 RASAL2 STIP1 PLXNA1 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 STMN2 EPSTI1 PTPN13 RND1 PLEKHG5 FRS2 FAM135A GRB7 VANGL2 FLOT2 DSP CAV1 RRAS2 CCDC88A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere H2BC9 ACD H2AZ2 TINF2 POLR2A H4C9 TERF1 POLR2B H2BC8 TERF2 POLR2C H2BC5 POLR2D H2BC3 POLR2E H3-4 POLR2F H2BC1 POLR2G POT1 POLR2H TERF2IP POLR2I POLR2J H2AC20 POLR2K POLR2L DAXX ATRX H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle CUL3 PLIN3 RAB9A RAB9B HGS VHL CCNE1 RHOBTB3 LRRC41 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLRMT POLG2 RNASEH1 TOP3A POLG TWNK MGME1 EXOG SSBP1 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance ALDOB COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 COL17A1 ITGB4 COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 PLEC COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 LOX COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 CTSS PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB LAMB3 P4HA1 LAMA3 P4HA2 P4HA3 LAMC2 COL1A1 COL1A2 ADAMTS14 MMP9 P3H2 P3H1 P3H3 PXDN MMP3 SERPINH1 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis GGPS1 LSS SQLE IDI2 ACAT2 MVD IDI1 MVK PMVK FDFT1 FDPS PLPP6 HMGCS1 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome TAF7L CCNT2 TAF4B ELOB ELOC RNMT CCNH POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L RNGTT GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 SUPT5H GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 TAF10 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 CD8B ATP6V1H TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion TRIT1 YRDC TRMU TRMT61B OSGEPL1 GTPBP3 TRMT10C MTO1 PRORP HSD17B10 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 POMT2 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs RBM8A ISL1 ETF1 GSPT2 GSPT1 UPF3A USP33 UPF2 LDB1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH HOXA2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 ZSWIM8 RPL34 MSI1 RPL10L RPL8 RPL10A RPL6 RPL7 LHX3 RPL7A RPL18A RPL36AL LHX2 RPL36 LHX4 RPLP2 RPL35 LHX9 RPL38 RPL37 COL4A5 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A ROBO2 RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CASC3 PSMB4 PSMB5 UBB PSMB2 PSMB3 NCBP1 SLIT1 UBC NCBP2 PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 BTK CFL1 ACTB MYO5A SYK PAK1 NCKAP1L WASF1 PTK2 WASF2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion PPIA CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA RELA XRCC6 XRCC5 NFKB1 DHX9 CTNNB1 CHUK IKBKB RIPK1 MYD88 ZBP1 TLR3 TREX1 DDX41 DTX4 TBK1 IRF3 NFKBIA STING1 NLRP4 TRIM32 TRIM21 TRIM56 IRF7 NLRC3 IFI16 CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F UBA52 POLR3G PRKDC DHX36 POLR3H POLR2K POLR2L POLR3K MRE11 NFKB2 RIPK3 NKIRAS1 LRRFIP1 NKIRAS2 IKBKG UBB CGAS AIM2 CREBBP UBC TICAM1 RPS27A EP300 STAT6 NFKBIB POLR1C POLR1D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways RELA MAP3K7 NFKB1 HSP90AB1 ITCH PANX1 CHUK MAP2K6 NLRP3 IKBKB IRAK1 CARD9 TAB1 TXNIP HMOX1 TNFAIP3 MAPK12 MAPK13 CASP1 CASP2 P2RX7 PYCARD TRAF6 BIRC2 BIRC3 NLRC4 CYLD NFKB2 NOD1 NOD2 IKBKG NLRP1 RIPK2 AIM2 BCL2 UBE2V1 BCL2L1 AAMP MAPK14 IRAK2 MAPK11 APP MEFV PSTPIP1 TAB3 TAB2 SUGT1 CASP8 TXN CASP4 CASP9 UBE2N BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport KIF28P KDELR1 KDELR3 KIF5C KIF21A KIF21B KIFAP3 KLC1 KLC4 KLC3 KLC2 RINT1 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 KIF3B SEC22B KIF3C RAB6B KIF5B KIF5A KIF18B KIF4B KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 BICD2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 PAFAH1B3 ARF5 NAPA GBF1 NAPB NBAS RAB6A RAB1A STX18 RAB1B NAPG GALNT1 BNIP1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 GALNT2 ARCN1 ZW10 KIF26A KIF26B RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 ACTR1A ARF1 DCTN2 CAPZA1 DCTN3 RACGAP1 ARFGAP1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 TUBB2B TUBB2A TCP1 CCT6B TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 UBC TICAM1 RPS27A TLR3 TBK1 IRF3 TRAF3 OPTN UBA52 IKBKE IRF7 TANK UBB ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP CHTF8 PRIM2 PRIM1 POLA1 DSCC1 POLA2 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 CHTF18 RFC2 RFC1 STN1 TEN1 CTC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis MAPK1 CTSG TRIM27 SFPQ RNF213 GSK3A MAPK3 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CREBBP BHLHE40 RBM4 DBP TFEB CRY2 CRY1 CIPC PER2 PER1 RORC PER3 RORA NR1D1 BMAL1 CRTC1 KMT2A SIK1 CLOCK NPAS2 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R4 GNG13 KCNJ2 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 SCNN1G SCNN1D SCNN1B SCNN1A TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 OTOP1 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis CHST15 CSPG4 CHST3 CHPF NCAN CHSY1 CHST11 BGN CHST12 CHSY3 DCN CHST13 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 UST CSPG5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs MON1A TRAPPC6A MON1B DENND1C TRAPPC6B DENND1B GDI1 DENND1A ULK1 RAB8B DENND2D TRAPPC10 RAB14 DENND2C DENND2B DENND2A RAB3IL1 GDI2 RAB7B DENND3 RAB21 ALS2CL RAB27B CHML RAB12 RAB13 TRAPPC4 CHM RAB9A RAB6B RAB9B RAB39A YWHAE AKT1 ALS2 RAB3A RAB31 RAB5B RAB5C RAB3IP RAB6A RAB1A RAB1B TRAPPC1 RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 GAPVD1 RAB7A RIC1 RAB32 RAB35 RGP1 RAB27A RAB38 AKT2 DENND6B RIN3 RAB3GAP2 RAB8A TRAPPC2L DENND6A RAB10 RIN1 RIN2 RAB3GAP1 RAB18 TRAPPC2 TRAPPC3 ANKRD27 DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B AKT3 TRAPPC8 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling TNFSF10 TNFRSF10B TNFRSF10A CASP10 CASP8 TNFRSF10D FADD CFLAR INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling TYK2 IL6ST JAK2 STAT3 CBL JAK1 SOCS3 IL6R STAT1 PTPN11 IL6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network SCOC SYS1 GCC2 GCC1 RAB43 GOLGA1 ARFIP2 RHOBTB3 COG8 COG7 COG6 NSF COG5 COG4 COG3 COG2 COG1 ARL1 VTI1A PLIN3 RAB9A RAB6B RAB9B RABEPK M6PR NAA30 IGF2R NAA35 NAA38 VAMP4 NAPA NAPB TGOLN2 TMF1 STX16 RAB6A NAPG STX10 ARFRP1 VPS51 GOLGA4 VPS53 VPS52 STX6 VPS54 VAMP3 RIC1 RGP1 USP6NL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY2 LEFTY1 SMAD4 SMAD3 CRIPTO3 FURIN DAND5 PCSK6 CFC1 CER1 NODAL GDF1 CRIPTO MAPK1 FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C FOXO3 MAPK3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MT1G MT1H MT1X MT4 MT1B MT3 MTF1 MT1E CSRP1 SNCB MT2A MT1A MT1M MT1F DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines SAT1 PAOX PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 POLE FEN1 RFC2 RFC1 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 APEX1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis ARV1 GGPS1 CYP51A1 LSS SREBF2 SQLE DHCR7 IDI2 ACAT2 MVD EBP LBR HSD17B7 DHCR24 PLPP6 NSDHL MSMO1 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC6A20 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling IFNA2 ADAR IRF1 IRF2 IFNA8 XAF1 IFNA13 HLA-H IFNA14 IFNA16 IFNA17 HLA-B BST2 HLA-C HLA-F HLA-G HLA-E OAS2 IFITM3 IFITM2 IFNA10 IFIT5 IFI35 IFNA21 IFIT3 IFNB1 IFIT2 EIF2AK2 ISG15 RSAD2 IFI27 STAT1 SOCS1 PTPN1 IP6K2 PTPN11 EGR1 IFI6 IFITM1 ISG20 IRF8 IRF6 IRF3 IRF9 IFNAR1 SAMHD1 HLA-A GBP2 IRF7 PSMB8 ABCE1 KPNA1 UBA52 OASL OAS1 OAS3 RNASEL JAK1 KPNB1 USP18 UBB IFIT1 UBC TYK2 MX2 RPS27A MX1 STAT2 SOCS3 PTPN6 IRF4 IRF5 IFNA5 IFNA4 IFNA7 IFNA6 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ACE2 FURIN ANO1 TMPRSS2 ANO10 ANO8 ANO9 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib ERBIN HSP90AA1 ERBB2 CDC37 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT SLC24A1 RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL3 PSMA7 PSMB6 PSMB7 HECW1 KLHL12 PSMB4 PSMB5 DACT1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 DVL1 PSMC4 PSMD8 DVL2 PSMC1 PSMD6 DVL3 PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis TYRP1 SLC45A2 TYR OCA2 DCT SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants FLT3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN APH1A FGD1 PSENEN FGD2 GNA13 NCSTN FGD3 APH1B PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ITGB3BP ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 SQSTM1 YWHAE CASP2 TRAF6 UBA52 BEX3 UBB UBC RPS27A TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 CASP3 TIAM2 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G2D PLA2G2E PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 PLAAT3 PLA2G2A LPCAT1 PLA2G4A PNPLA8 PLA2G4F PLA2G12A TMEM86B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 PLB1 LPCAT3 PLBD1 LPCAT2 PLA2G2F MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation YAP1 GLI3 HEY1 HES1 BGLAP HEY2 ABL1 RB1 WWTR1 SRC YES1 MAF HDAC3 COL1A1 SATB2 MAPK1 HDAC6 SP7 UCMA MAPK3 CBFB ZNF521 AR CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins EPB41L3 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 EPB41L1 STX1A SHARPIN SYT9 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 CASK NRXN2 GRIN2A LIN7A DLG2 LIN7C DLG3 LIN7B DLG4 PDLIM5 NLGN4Y NLGN4X SYT10 SYT12 APBA1 SYT1 DBNL GRM1 GRM5 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 FGF18 FGF1 FGF2 FGF4 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs CDC42 RAC1 IQGAP1 IQGAP2 IQGAP3 CTNNB1 CDH1 MEN1 CALM1 CLIP1 CTNNA1 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling CLTC CLTB TIAM1 CLTA AP2A1 AP2A2 ARHGEF7 ARPC1B NGEF ARPC1A AP2M1 RHOA KALRN APH1A PSENEN ROCK1 NCSTN ROCK2 APH1B PSEN2 CLTCL1 ARPC4 ADAM10 ARPC5 PSEN1 ARPC2 ARPC3 DNM1 ACTR3 ACTR2 ARHGEF28 SDC2 CDC42 AP2S1 AP2B1 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 GRIN2B EPHA1 EPHA3 GRIN1 MYL9 EPHA10 EPHB6 EFNB2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 EFNA5 EFNA4 CFL1 GIT1 EFNA1 EFNA3 WASL EFNA2 ACTG1 MMP9 ACTB MMP2 NCK2 EPHA2 ITSN1 RASA1 SDCBP YES1 PAK1 PAK3 LIMK2 RAC1 HRAS LIMK1 MYL12B FYN VAV3 MYL6 MYH9 MYL12A MYH14 MYH11 MYH10 PAK2 PTK2 VAV2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE5A MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 SLC35A1 CHST10 DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A4 FKRP CRPPA POMGNT1 B4GAT1 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs ALK HIP1 PRKAR1A CLTC STRN PPM1B BIRC6 NPM1 EML4 FN1 EIF2AK3 BCL11A SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) TIAM1 SOS1 FRS3 CDK5 NTF3 PIK3R1 NRAS PLCG1 SRC DOCK3 RAC1 HRAS GRIN2B NTF4 NTRK2 BDNF GAB1 FRS2 PIK3CA CDK5R1 PTPN11 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CB JAK2 PIK3CD LYN GAB1 PIK3R1 PIK3CG PIK3CA PIK3R5 EPO EPOR IRS2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS HRAS RAPGEF1 SOS1 JAK2 SHC1 LYN NRAS CRKL EPO VAV1 EPOR IRS2 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases UBC GYG1 RPS27A SLC37A4 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 EPM2A PPP1R3C NHLRC1 GAA G6PC3 UBB GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism GCKR GCK PPP2R5D G6PC1 PC PRKACG PRKACA PRKACB PCK1 PPP2CA PPP2CB SLC37A4 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK2 PGK1 SLC37A1 NUP37 PGK2 G6PC2 PFKL G6PC3 FBP1 GNPDA1 FBP2 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP CITED2 ARNT CA9 HIGD1A VEGFA EPAS1 EP300 HIF1A EPO ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MRAS PPP2R5B PPP2R5A PPP2R5D PPP2R5C NRAS PHB1 MAP3K11 ARAF SHOC2 RAF1 JAK2 MARK3 BRAP KSR1 PPP1CB PPP1CC BRAF PPP2R1B PPP2R1A PPP2CA PPP2CB CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS MAP2K1 MAP2K2 CALM1 CAMK2G PPP2R5E ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism CYP4B1 FAAH DPEP2 DPEP1 ALOX15 LTA4H PTGES3 PTGDS CYP4F3 CYP4F8 CYP2J2 PRXL2B PLA2G4A GGT5 PTGES PTGR1 CYP4A22 PTGR2 GGT1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 ALOX15B LTC4S PON3 HPGD PON2 PON1 EPHX2 GPX2 HPGDS ALOX5AP MAPKAPK2 CBR1 CYP4F22 CYP2C9 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 CYP4F11 SLC27A1 TBXAS1 PTGES2 ALOX12 GPX1 GPX4 CYP8B1 FAAH2 AKR1C3 AWAT1 ALOXE3 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 MAPK1 MAPK8 IFNB1 MAP3K5 MAP2K6 MINK1 MAPK3 TNRC6C TNIK MOV10 BMI1 AGO3 CBX6 AGO4 RING1 MAP4K4 AGO1 MDM2 TNRC6A MDM4 TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 EED CDKN2D CDKN2C MAPKAPK2 UBA52 CDKN2B E2F1 RBBP4 E2F2 MAPKAPK5 E2F3 EZH2 CDK6 TFDP1 RBBP7 TFDP2 CDK4 H2AX MAP2K3 UBB MAP2K4 H2AB1 MAPKAPK3 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 MAPK9 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 H2BC17 MAP2K7 H2BC12 H2BC13 MAPK10 H2BC14 H2AJ H2BC15 FOS TP53 H2BC11 TXN KDM6B H3C15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors APOA1 SSC5D S100A9 PRDX1 CD5L APOB CD36 SAA1 HMGB1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin TPGS1 TPGS2 TUBB8 AGBL5 AGBL4 AGBL1 AGBL3 TUBA1C AGBL2 TUBA1B TUBB8B TUBA1A LRRC49 VASH2 VASH1 TUBB2B TUBB2A TTLL7 TTLL6 TTLL5 TTL TTLL4 TUBB6 TTLL3 TUBB3 TTLL2 TUBA3E TUBB1 TTLL1 SVBP TTLL9 TTLL8 TUBA3D AGTPBP1 TUBA3C TTLL10 NICN1 TTLL13 TTLL11 TTLL12 TUBB4B TUBB4A DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions CLEC5A SOS1 SIGLEC14 PIK3R2 PIK3R1 HLA-B KLRK1 HLA-C KIR3DS1 NRAS PLCG1 BTK HLA-E GRAP2 NCR2 KIR2DS2 SIRPB1 KIR2DS4 KIR2DS5 CD300LB TREM1 SIGLEC16 SIGLEC15 CD300E LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 PRIM2 PRIM1 POLA1 H2AX POLA2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L POLE H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 CDC45 KPNA6 MCM10 DBF4 RPA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors STAB1 APOB SPARC STAB2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCB6 ABCB4 SEL1L KCNJ11 ABCC8 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 ABCD4 VCP ABCC2 ABCA1 ABCG8 ABCC6 ABCG5 LMBRD1 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 ABCA3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ABCA12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora EPM2A UBC GYG1 RPS27A PPP1R3C NHLRC1 UBA52 GYS1 UBB THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism SDS SDSL RIDA P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway HLA-H CTSV B2M HLA-B CTSL HLA-C CTSS HLA-A HLA-F HLA-G HLA-E LNPEP GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TOPORS SUMO2 UBE2I SUMO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling CBL UBA52 FGF20 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF7 FGF9 MKNK1 SPRY2 FRS2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence RPS6KA1 JUN CXCL8 RELA HMGA2 H1-1 H1-0 H1-3 LMNB1 IFNB1 CABIN1 H1-2 MAP2K6 H1-5 H1-4 HIRA UBN1 EP400 ASF1A MDM2 MDM4 IL6 EED CDKN2D CDKN2C RB1 HMGA1 CDKN1B FZR1 E2F1 IGFBP7 RBBP4 E2F2 MAPKAPK5 E2F3 CDK6 IL1A TFDP1 RBBP7 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TXN KDM6B H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 VENTX TERF2 H2BC8 H2BC5 H2BC3 MAPK7 STAT3 H3-4 H2BC1 NFKB1 CDKN1A POT1 TERF2IP H2AC20 CDKN2A MAPK1 CDK2 MAPK8 MAP3K5 CEBPB MINK1 MAPK3 ETS1 ETS2 EHMT2 EHMT1 ERF TNRC6C TNIK MOV10 ID1 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 MAP4K4 TNRC6A TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 MAPKAPK2 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 EZH2 KAT5 NBN MAP2K3 UBB MAP2K4 MAPKAPK3 UBC SP1 RPS27A MAPK9 MAPK14 MAPK11 MAP2K7 RAD50 MAPK10 TP53 FOS CCNA2 ATM CCNA1 RPS6KA3 RPS6KA2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease HRAS SOS1 FGFR4 GAB1 FRS2 PIK3R1 NRAS PIK3CA PLCG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 PRDX1 RELA MAFG PGD NFKB1 ABCG2 NQO1 CDKN2A GSTA3 GSTA1 SRXN1 CHD6 CCL2 ABCF2 PRKAA2 SOD3 G6PD SQSTM1 ATF4 GCLC TKT ABCC3 MYC ABCC1 GCLM PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B IDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF PSMA2 UBA52 PSMD12 PSMD11 ME1 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 BACH1 UBB TXNRD1 PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 PSMB1 BCL2 PDGFA RPS27A MAFK SLC7A11 AREG NFE2L2 BCL2L1 EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TXN NOTCH1 CUL1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane MTMR3 MTMR8 MTMR9 RAB14 PIK3R2 MTMR6 PIK3R1 PIP5K1A PIP5K1B MTMR14 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B INPP5J INPP5K PI4K2A PTEN MTMR1 PIP5K1C INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RAB4A RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 INPPL1 RUFY1 PIK3CA PIK3R3 SBF2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate CHIA AMY2A AMY1A MGAM AMY2B TREH AMY1B SI AMY1C LCT CHIT1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) GP5 SERPINA5 GP9 SERPING1 KLKB1 CD177 THBD GP1BA KNG1 C1QBP FGB F3 FGA VWF FGG PF4 F2R A2M PRCP TFPI F13B PRTN3 SERPINC1 F7 F13A1 F9 PROC F10 SERPIND1 F5 PROS1 PF4V1 F8 F2 SERPINE2 GP1BB F12 F11 PROCR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination SRSF6 CLP1 SRSF7 MAGOH ZNF473 SNRPD3 SNRPB SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF7 CPSF1 ALYREF DDX39B CPSF3 CSTF3 CSTF2 CPSF2 SRRM1 CSTF1 DHX38 SYMPK UPF3B MAGOHB RNPS1 PCF11 WDR33 LUZP4 POLDIP3 SRSF1 SLU7 CSTF2T U2AF1 FYTTD1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SRSF11 NUDT21 CASC3 PAPOLA LSM10 NCBP1 LSM11 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SNRPG SRSF2 SRSF3 SNRPE EIF4A3 SRSF4 SNRPF SRSF5 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 SLIT1 SLIT3 DCC NTN1 NELL2 SLIT2 ROBO1 SRC DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling AIP ARNT2 PTGES3 ARNT AHRR HSP90AB1 AHR STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 RAF1 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 TRPM1 SRI TRPM2 TRPM7 TRPM8 TRPM5 WNK1 TRPM6 TRPM3 WNK2 TRPM4 WNK3 TRPC7 TRPC5 MCOLN3 TRPC6 RYR1 TRPA1 RYR2 TRPC3 RYR3 TRPC4 UNC80 TRPC1 TRPV2 TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 STOM NEDD4L SGK1 CALM1 UBA52 WWP1 UBB UBC RPS27A OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System SEL1L ERLIN1 ERLIN2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 UBE2V2 RAC1 VAV3 COPS5 UBE2N VAV1 VAV2 ADAR SOS2 DCTN6 DCTN5 DCTN1 DCTN4 HSPA1L HSPA2 CAPZA3 MAPK8 BCL2L11 CAPZA2 ACTR10 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 UBE2I SUMO1 UBE2D2 UBE2D3 ELOB ELOC RBX1 EPAS1 CUL2 HIF1A VHL POLR2E POLR2F POLR2H POLR2K POLR2L KRT1 ACTB FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B TP53 FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 SPHK1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 TCP1 BTNL2 XDH MT2A CCT8 TUBB4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 DSC1 NUP50 NUP35 NUP54 NUP37 ACTG1 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DSN1 DIAPH1 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 RHOA KIF2A BIRC5 EVL KIF2C KIF2B CHUK DYNC1I2 IP6K2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE EIF2AK3 CENPS CRCP MCL1 POLR3GL POLR3A POLR3B VEGFA POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IL22 NFKB2 CD274 IL2RG LRRFIP1 FCN2 BIN2 FCN3 CRP COLEC10 SKP1 CUL1 SLC15A4 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 CA1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 PRKRA IGKV4-1 TARBP2 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM LAMA5 SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 BRWD1 IGLC3 BLNK IGLC1 VTN IGLC2 JAK3 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 BRD4 IGLC7 IGHV3-53 IGKV5-2 STAT2 IGLC6 IGKV1-5 IMPDH1 IMPDH2 PDCD1 LIMK1 EEF1A1 MYH9 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 IL23R FBXO9 IL13RA2 IL13RA1 HLA-H IL4R WSB1 FBXO2 IL23A HLA-B FSCN1 HLA-C NDN ATG14 LIF NANOG HLA-F IGHE HLA-G HSP90AB1 HLA-E OPRD1 OSM RNF126 CDC34 BATF HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 PRKAA1 ATG7 PRKAA2 CAB39 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 CD207 CALR FBXL4 MLST8 DZIP3 RNF220 EIF4E DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 MTOR LRRC41 VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 LAMTOR2 UBE2G2 LAMTOR1 PSMB8 PSMB9 LAMTOR3 KLHL9 SPSB2 CYFIP1 NCKAP1 SPSB1 KBTBD6 NCF1 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 BRK1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z STBD1 FBXO22 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 RAPGEF1 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 RAB7A TRAIP RNF41 KLHL42 UBE2V1 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 ABL2 FBXO40 NCKAP1L BTBD1 LONRF1 WASF1 UBE2F PAK2 RAG2 UBE2H RAG1 KLHL25 WASF2 UBE2B IL32 ZBTB16 RASGRP4 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 BAIAP2 FBXO31 KLHL20 UBE2W UBOX5 ABI2 UBE2U RNF182 UBA3 ABI1 UBE2O TPP2 UBA1 BLMH UBE2K TGFB1 UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 LMNB1 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP IL1RL2 PJA1 IL36A TAPBP IL36B TRAF7 IL36G UBE2R2 IL36RN SEC22B IL1F10 THOP1 TRIM50 SEC23A MGRN1 ASB13 ASB14 ASB11 CLEC10A RNF6 CLEC4A ASB12 WIPF1 CLEC4E RNF7 WIPF2 CLEC6A ASB17 WIPF3 DHX58 RNF4 RNF125 TAX1BP1 ASB18 RNF216 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 TNFRSF6B HECTD1 EDA HECTD2 TNFRSF13B HECTD3 TNFRSF11B ASB10 EDA2R TNFSF13B FCGR1A TNFRSF17 SEC24B TNFRSF8 TRIM41 ARHGAP45 TNFSF11 SEC24A TNFRSF4 ERAP2 EDARADD RNF25 TNFSF18 FBXL19 IQGAP1 TNFSF14 PLD1 ERAP1 TNFSF15 FBXL15 IQGAP2 FBXL16 CD70 TNFRSF9 FBXL13 EDAR FBXL14 FBXL12 TNFSF6 TRIM39 TNFSF4 LTA ASB8 JUP CD27 ASB9 LNX1 TNFSF9 TNFRSF25 ASB6 ASB7 TNFSF8 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 ARHGAP9 SEC24C ASB1 WASL PTPRZ1 PAG1 WAS STOM PAK3 MYO9B COLEC12 MAP2K1 COLEC11 HSP90B1 ITGAV NCAM1 FTH1 MASP1 FTL ITGB5 XRCC6 XRCC5 PDCD1LG2 B3GNT3 SPOP ITGAX PIAS1 SUZ12 GSK3B GPI ABCE1 HK3 KLRK1 PGAM1 KIR3DS1 PRKDC DHX36 FCER1A LAT2 BCL10 NCR2 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E LPO NKIRAS2 MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 BCL2 TLR10 TLR5 ALPK1 LRRC14 NLRX1 NFE2L2 BCL2L1 PELI3 BTLA PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 JUN IFNA2 IFNA8 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 OAS2 IFNA10 IFNA21 IFNB1 PTPN22 EIF2AK2 ISG15 CD209 NOS1 APEH FGR STIM1 ORAI2 PECAM1 ORAI1 ITPR1 ITPR2 ITPR3 APOB NOS2 NOS3 MME P2RX7 P2RX1 IST1 KPNB1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 RPN2 TUSC3 PRKCSH RPN1 MAGT1 LTA4H ATF6 GOLGA7 OST4 LGMN DDOST LPCAT1 TMEM258 DAD1 OSTC CANX STT3A STT3B PTGS2 ALOX5 KEAP1 TRIM25 RNF123 GATA3 TNFRSF12A TNFSF12 SIAH2 TNFRSF13C TNFRSF11A CD40LG CYLD LTBR LTB IFIH1 TRIM4 IKBKG TOMM70 RIPK2 OSBPL1A PIK3CD PRKN RNF135 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 SMAD3 CXADR SMURF2 SMAD7 NFKBIA MAVS TAB1 RIGI PTEN TNFAIP3 CD74 SLC44A2 GLIPR1 JAML CD99 TRAF2 TRAF3 TRAF6 BIRC2 BIRC3 USP14 BECN1 NOD1 NOD2 USP18 ORMDL3 PTGES2 TNIP2 INPPL1 EIF4A3 ALOX15 PLD4 PLD3 DHX9 ALDH3B1 PCBP2 DEGS1 HNRNPF HNRNPA2B1 ILF3 MYO5A RAB27A THOC5 CEACAM1 ZEB1 IRF4 PPIE CCR5 FPR2 YBX1 SNRPA1 ANXA1 PTAFR MMP3 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA IRAK3 EBI3 MEF2C IFNLR1 B4GALT1 IL20 IL25 IL26 IL24 IL27 IL11 IL19 IL16 IL17RE OSMR IL17RB TXNIP IL31 IL17C IL11RA IL7 IL7R IFNL2 IFNL1 IFNL3 SFN COL1A2 EZH2 KCNAB2 CASP10 FAAP100 FAAP24 FAAP20 FANCM CTLA4 FANCL FANCA FANCB FANCE FANCG FANCF RICTOR STAT1 RORC RORA PDE12 OASL OAS1 OAS3 RNASEL BLK KMT2C FOXO1 SOCS3 NDUFC2 FBXO32 NFKB1 PIN1 FASLG ITGAL TRIM63 ITGA4 TNFRSF18 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 IL2RA NCR3 CD200R1 HCST MUC12 LILRA6 MUC15 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 PTPN4 NCR3LG1 LAIR2 MICA MUCL1 MUC3A MICB MUC5AC NPDC1 MUC3B GLYCAM1 LILRB1 KIR3DL1 LGALS3 KIR3DL2 CFP LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 MUC1 CD8A MUC2 KLRF1 CD300C CLEC4G KLRB1 MUC7 KIR2DL1 MUC4 KIR2DL2 MUC6 KIR2DL3 MUC16 KIR2DL4 CD300LD MUC17 KLRC1 CD300LF MUC19 CD300LG CD160 CRTAM MUC5B MUC20 ULBP1 MUC21 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 WWTR1 YES1 EEF2 SMARCA4 MLEC CTSV CTSL CTSK GBP7 TRIM8 TRIM6 YAP1 TRIM5 TRIM2 TRIM3 CSH1 RELA XAF1 CIITA TRIM68 TRIM62 TRIM46 TRIM48 ARPC1B TRIM45 ARPC1A NPM1 TRIM35 TRIM38 TRIM31 TRIM34 ITCH KLC1 IFITM3 KLC4 IFITM2 KLC3 IFIT5 KLC2 ARPC4 IFI35 ARPC5 IFI30 ARPC2 IFIT3 ARPC3 IFIT2 TRIM29 NF2 ACTR3 TRIM26 ACTR2 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR RAB9B KIF5B IRF8 IRAK1 KIF5A IRF6 NCKIPSD IRF9 SAMHD1 HLA-DOA HLA-DOB LAG3 IL2 CTSO IL3 CTSF IL6 MGST1 CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG CSF1 C4A EED CAT RETN SOD2 FUCA2 KRAS MMP1 MMP2 DNAJC3 JUNB RNF111 PRKCB CST3 PRKCQ CRKL MAPKAP1 NEDD4L CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 NFATC2 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI CDK13 C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A ASH2L C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 CD46 C1QB TEAD2 C1QA C1S C1R TEAD3 TEAD4 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC ICOSLG SNAP25 RAB3A DNAJC5 IL1RN WWP1 IL18RAP IL1R2 IL4 TOLLIP PTPN20 PTPN23 IL18BP IL13 IL1RAPL1 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 CSF2 PTPN7 PTPN5 IL18R1 PTPN2 CNPY3 TLR8 CTSB FKBP5 KPNA7 KPNA4 KPNA5 GBP1 CSF1R KPNA3 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 FANCC PYGL MMP25 TIMP2 OLR1 SERPINB3 BCL6 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 GSTP1 AGA AOC1 AGL ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B WDR5 RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RNF34 RAB5B NLRC4 RAB5C BRI3 HVCN1 GPR84 RAB6A RBBP4 TXNDC5 TRAPPC1 RBBP5 RAB4B PTPRB PTPRC NIT2 RBBP7 ITGAM ITGB2 FCAR ALAD FCGR3B PGM2 ACP3 SNAP29 PML PGM1 RNASET2 TNFRSF1B PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 SOX2 CPPED1 RAB10 NFASC TSPAN14 FCGR2A RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 TWIST1 TXN CHIT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PRG3 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 LIFR CD47 CD44 KCTD6 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 LAIR1 SMURF1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CASP1 CD93 CASP2 CD300A IRAG2 OPRM1 ATAD3B OSCAR TYROBP DOK3 COPB1 IFNG ADGRG3 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 POMC CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 CSK JAK2 NAPRT ADGRE3 HGSNAT FGB DYNLT1 ATP6AP2 FGA PLAUR MMP8 MMP9 FGG CHI3L1 PDXK CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN PROS1 F2 CLTC CLTA CXCL8 AP2A1 CXCL2 AP2A2 AP2M1 CCL11 CCL3L3 CCL5 NPC2 CCL4 CCL3 CCL2 SAR1B CCL19 CCR1 AP2S1 CCL22 CCL20 CXCL10 AP2B1 P4HB POU2F1 LBP VASP STAT5A IL10RA ITK TRAC CD3G FLNA CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 FCGR3A MYH2 MYO10 MYO1C AMPD3 APRT PNP PPP3CA PPP3CB PPP3R1 NFATC1 DNM2 EGR1 JUND FOSB GBP5 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 SLA SLA2 SOCS2 SOCS6 SH2B3 IKBKE IRF7 TANK ACTR1A NEK2 CEP290 NFATC3 TUBB DCTN2 DCTN3 MEFV PSTPIP1 SUGT1 CALM3 CALM2 ATP8A1 IL34 GAB3 ATP11B ATP11A CARD11 MALT1 ATP8B4 RELB CLEC7A CARD9 MAP3K14 GBP6 ANO6 CENPX KIF23 KIF20A DGAT1 FABP5 PRL SNCA DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 SIKE1 IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R TNF CEBPD STAT6 POLR1C POLR1D AGPAT2 GM2A ARSA ASAH1 PSAP TKFC MBL2 GLA IL17RC IL17RA IL17F IL17A CRK UBE2L3 FADD CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 IL1A IL1B PELI1 TLR4 GSN FNTA TICAM2 TICAM1 PKP1 LY96 SDCBP MAOA HMGB1 CASP8 CASP5 CASP4 DSP IRF1 IRF2 DSG1 NCSTN ADAM10 PSEN1 FBXL18 FBXL7 DNM1 FCER2 DNM3 MAPK12 MAPK13 SDC1 HPSE GH1 LYN INPP5D PIK3CG PIK3R6 PIK3R5 BTK ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 JAK1 CISH IL12RB2 HSPA9 IL10 SERPINB2 SOCS5 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 AAMP PPIA AHCYL1 KPNA2 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ADAM17 CYFIP2 HMOX2 TEC STK10 FLT3 IRS1 IRS2 EIF4E3 IFIT1 PIK3CB TCIRG1 PPM1B EIF4E2 FLNB FGF2 CAPZB MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS WASF3 ATP6V1G1 ATP6V0B ATP6V0E1 CD180 LY86 ATP6V1G2 PTPN13 EEA1 PDPK1 TASL RBSN FLT3LG IRF5 GAB2 PIK3CA PIK3R3 ATP6V1B2 TLR9 PIK3C3 TRIB3 ATP6V0D1 FAF2 SOS1 SH3RF1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS RHOU ATP6V0A2 THEM4 ATP6V1H MAPK1 ATP6V0A4 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PTPN1 PTPN11 PLD2 UNC93B1 TLR3 CAMK2B CAMK2D SRC CAMK2A CKAP4 ZAP70 LRRC7 CALM1 DOCK2 CAMK2G DOCK1 ANAPC7 MOSPD2 UBE2C PTK2B UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 ARMC8 FBXW11 OPTN SEM1 APP F13A1 LAMP2 HGF ARG1 SERPING1 PGLYRP4 PGLYRP3 STXBP2 DEFB105B PGLYRP2 KIF5C LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B KIFAP3 S100A7A HSPA5 HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 KIF3B SERPINA3 DEFB117 ORM1 DEFB116 SLC11A1 KIF3C SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 KIF4B DEFB112 ORM2 RNASE3 KIF4A DEFB110 TLR1 DEFB130A BPI KIF11 PRTN3 QSOX1 TIMP1 DEFB130B S100A9 CAP1 DEFB4B S100A8 KIF15 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 KIF22 DEFB123 STX4 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A S1PR1 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 KIF26A ACLY ATG5 ATG12 SLC27A2 TCF7L2 CDKN1A TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ACAA1 EIF2S2 EIF2S1 EIF2S3 ATF3 TREM2 TNRC6C MOV10 MYCN STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 HMOX1 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 NUP214 IDH1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 HSPA8 ICAM1 TNFSF13 VAMP2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 APAF1 CASP3 CFD C3 GZMM CFB FURIN VAPA IL1RL1 IL33 CCT2 ROCK1 CUL3 KIF3A VCAM1 RBBP6 VIM AP1G1 ZBP1 AP1S2 TREX1 AP1S1 DDX41 ITGB7 AP1S3 DTX4 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 NLRP4 TRIM32 HLA-A TRIM21 CD8B TRIM56 ELMO1 CD28 HEXB TNFRSF1A GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 NEDD4 MKRN1 FRK CBL PLCG1 CDKN1B FZR1 FNTB SKP2 CDK4 H2AX CSF3R H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CHRNB4 MYLIP NEU1 FBXL21P CTSA REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 F9 PROC F10 PROS1 FURIN PROZ F2 BGLAP GAS6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R5D PPP2R1B MLXIPL PPP2R1A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases SERPINB1 IL18 CASP5 IL1B CASP4 CALM3 CALM2 GSDMD CALM1 CASP3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 OAZ1 OAZ2 ADRM1 OAZ3 AZIN1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants FLT3 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR7 SC5D DHCR24 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA NGFR LINGO1 MAG OMG RTN4 MCF2 RHOA NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism CD38 BST1 NMNAT3 NMNAT2 NMNAT1 NUDT12 NADK NNMT NAPRT NADSYN1 NMRK2 NMRK1 NAXE NADK2 NAXD NAMPT RNLS SLC22A13 NT5E QPRT SLC5A8 PARP10 SLC25A51 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle ARL6IP5 GAD1 GAD2 CHAT SLC18A3 SLC17A7 NAAA STX1A CASK LIN7A LIN7C LIN7B APBA1 SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT GLS2 SLC6A1 CPLX1 RIMS1 UNC13B ALDH5A1 GLS DNAJC5 SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC1A1 SLC1A2 SLC1A3 SYN3 SLC1A6 SYN2 SLC1A7 HSPA8 VAMP2 SLC38A2 MAOA SYN1 SLC6A11 SLC6A12 SLC5A7 TSPOAP1 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle CLTC IQGAP1 PTK2B VANGL1 WWP2 ARHGEF7 PIK3R2 PIK3R1 RHOU ARHGEF6 STAM ARHGAP31 ARHGAP30 SPTAN1 STAM2 GIT1 TXNL1 HGS MYO6 CDC42 DEPDC1B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 SRC ITSN2 PAK1 PAK3 SRGAP2 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair PCNA ERCC6 PCLAF REV1 ISG15 USP43 SPRTN MAD2L2 REV3L ISY1 FIRRM SIRT6 PNKP POLK POLE OGG1 PIAS3 UBE2T RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 UBE2L6 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 HERC2 ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 CDK2 MAPK8 MDC1 FEN1 USP1 DTL UBE2I SUMO1 RBX1 TRIM25 NFRKB CCNH PIAS4 POLR2A POLR2B POLR2C BRCC3 POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J NPLOC4 POLR2K POLR2L MSH3 GTF2H1 GTF2H2 BAP1 GTF2H3 WDR48 GTF2H4 BABAM1 GTF2H5 BABAM2 CDK7 ERCC3 POLI ERCC2 UIMC1 MNAT1 UFD1 ACTB UBB ACTL6A UBC DDB2 RPS27A FAAP100 FAAP24 FAAP20 UBA7 FANCM ERCC8 FANCL FANCA FANCB FANCE FANCG FANCF KPNA2 TP53 DCLRE1C RIF1 MCRS1 POLL NHEJ1 UBE2B POLM TDP2 TDP1 PARG APEX1 ADPRS POLQ KDM4B YY1 RUVBL1 USP7 ABL1 PMS2 MPG MUS81 GPS1 SLX4 EME1 INO80C EME2 INO80B GEN1 INO80E SLX1B VCP INO80D COPS4 SPIDR FANCI COPS2 FANCC CLSPN RNF4 FIGNL1 POLB RNF168 NSD2 CENPX ACTR5 RAD23A ACTR8 RAD23B MSH2 RTEL1 ABRAXAS1 USP10 TP53BP1 UVSSA H2AX TFPT LIG1 H2AB1 MSH6 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 DCLRE1B H2BC21 DCLRE1A POLN FAN1 RNF8 H2AC8 H2AC6 CHEK2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG MBD4 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 MGMT TERF2 H2BC8 H2BC5 SMUG1 NEIL3 XRCC6 H2BC3 AQR XRCC4 H3-4 NEIL2 XRCC5 PARP1 H2BC1 POT1 LIG4 TERF2IP PPP4R2 NEIL1 TIPIN H2AC20 TIMELESS ZNF830 PPP4C POLH RAD52 MLH1 KDM4A FANCD2 SUMO3 SUMO2 PIAS1 PRPF19 PAXIP1 SMARCA5 CENPS PRKDC BAZ1B XAB2 BLM MRE11 RAD18 BRCA1 BRCA2 RAD51AP1 ELL WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 APBB1 RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 EYA4 PPP5C RMI1 TCEA1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 PPIE CCNA2 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR KANK1 ETV6 GOLGA4 BIN2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INS ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 PTPN1 INSR TCIRG1 IDE PTPRF ATP6V1E1 CTSD ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs RASA3 RASA4 RASA2 NRAS CUL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 KBTBD7 PSMA4 PSMA1 NF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 SPRED3 SPRED2 PSMB7 SPRED1 RASAL2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RASA1 ADRM1 SYNGAP1 PSMC5 PSMC6 HRAS SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DAB2IP RASAL1 RASAL3 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 SEC61A2 SEC61A1 CHUK TIRAP TAPBP IKBKB SEC22B MYD88 CALR B2M HLA-A TLR1 VAMP8 S100A9 PSMB10 PSMD8 PSMD6 TLR6 S100A8 PSMD7 TLR2 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMA5 STX4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK CD14 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 FGA PSMB4 TAP2 FGG PSMB5 IKBKG TAP1 TLR4 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A LY96 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 HMGB1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB ACADL HADHA ECHS1 HADH SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 SENP5 NUP107 SENP2 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 SENP1 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG RWDD3 UBA2 DNMT1 SAE1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency OTC BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A2 CYP1A1 ALOX15 LTA4H MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 TAB1 MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PTK6 CDKN1A CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 NUMA1 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events PRKCA PLCB4 GNAQ ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 NBEA PLCB2 CALM1 CAMK2G PRKCD INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling IFNA2 TRIM6 TRIM5 IFNA8 TRIM2 TRIM3 ARIH1 XAF1 IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 NPM1 TRIM45 TRIM35 TRIM38 OAS2 TRIM31 TRIM34 IFITM3 IFITM2 IFNA10 HSPA5 IFIT5 IFI35 IFNA21 IFI30 RAF1 IFIT3 IFNB1 IFIT2 EIF2AK2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 ISG20 YBX1 PRKRA IRF8 IRF6 TARBP2 IRF9 IFNAR1 SAMHD1 PTAFR FLNA HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 KPNB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 FNTA DNAJC3 STAT2 UBE2L6 HERC5 UBE2N ADAR IRF1 IRF2 HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E HSPA1L HSPA2 ATF6 HSPA1B SOCS1 EIF2S2 IFNGR1 EIF2S1 IFNGR2 EIF2S3 EGR1 IKBKB EIF4E UBE2I GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 IRF7 PSMB8 NUP214 PRKCD SFN UBA52 IFIH1 JAK1 ACTB IKBKG UBB UBC TYK2 PTPN2 RPS27A FAAP100 FAAP24 HSPA8 ICAM1 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 KPNA7 FKBP5 KPNA4 KPNA5 GBP1 KPNA3 FURIN FCGR1BP SPHK1 MAP2K6 STAT1 MT2A VCAM1 FANCC B2M SMAD7 IRF3 MAVS HLA-A TRIM21 GBP6 RIGI NUP205 POM121 NUP107 NUP188 FCGR1A AAAS NUP160 POM121C NUP42 NUP85 TPR CENPX NUP62 NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B PML EIF4E2 FLNB MX2 MX1 EIF4G3 EIF4G2 NCK1 SOCS3 EIF4A2 EIF4A1 IRF5 EIF4A3 NCAM1 PPP2R5A STAT3 BST2 MAPK1 DHX9 PIN1 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CD44 PPP2CA PPP2CB IFITM1 CAMK2B PIAS1 CAMK2D SNCA CAMK2A CASP1 EIF2AK3 CAMK2G CENPS IFNG ABCE1 UBE2E1 CDK1 JAK2 ILF3 PTPN6 IRF4 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 TRIM8 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CLPS CEL LIPF PNLIP PNLIPRP3 PNLIPRP1 PNLIPRP2 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors AP2A1 AP2A2 NPM1 AP2M1 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 BTRC NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 KPNB1 CD4 RCC1 RAC1 RANBP1 RANGAP1 ATP6V1H PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 DOCK2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 ARF1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNT1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDK9 RPS27A CUL5 ADRM1 PPIA HCK PSMC5 PSMC6 SEM1 LCK PSMC3 FYN PSMC4 PSMC1 PSMC2 SKP1 PAK2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis XIAP CYCS STAT3 DYNLL1 UACA BAK1 GZMB CDKN2A DYNLL2 MAPK1 BID PPP1R13B MAPK8 BCL2L11 MAPK3 BAD PMAIP1 YWHAB YWHAE AKT1 YWHAQ YWHAG YWHAH YWHAZ SFN GSDMD NMT1 GSDME PPP3CC BAX C1QBP E2F1 TP63 TFDP1 TFDP2 CARD8 BBC3 BCL2 BCL2L1 AKT2 BMF AVEN TP73 APIP TP53 CASP8 CASP9 PPP3R1 TP53BP2 CASP7 APAF1 DIABLO CASP3 AKT3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species NCF1 PRDX2 CYCS NCF2 PRDX1 NCF4 NUDT2 CAT PRDX3 NOX5 ERO1A TXN2 GPX3 GPX6 GPX5 GPX8 SOD2 GPX7 ATP7A CYBB TXNRD2 CYBA PRDX6 ATOX1 SOD3 CCS TXNRD1 SOD1 P4HB GPX1 GSTP1 AQP8 TXN NOX4 GPX2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) MSH6 MLH1 PMS2 MSH2 MSH3 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i ALG2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CAMK2D CALM1 CAMK2G CAMK2A REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements ATF7IP ZNF547 ZNF224 MBD3 GATAD2B GATAD2A ZNF778 RBM7 ZNF454 CHD4 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 MTA1 MTA3 RBBP7 SMARCE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MORC2 H2AC6 H2AC7 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ZNF141 HDAC1 ZNF382 H2AC20 ZNF418 ZNF354A ZNF136 ZNF649 EHMT2 EHMT1 CHD3 SUMO2 UBE2I DPF1 HDAC2 DPF2 DPF3 ZNF28 CBX5 ZNF273 SETDB1 SS18L1 ARID1A ARID1B ZNF816 ZNF610 SS18 SMARCB1 ZNF264 PPHLN1 TRIM28 ZNF30 ZNF257 SMARCC1 SMARCC2 ZNF33A MPHOSPH8 ACTB SPOCD1 ZNF331 ZNF93 ZCCHC8 ACTL6A MTREX TASOR ZNF708 ZNF324 ZNF534 PIWIL4 DNMT3L BCL7A ZNF320 BCL7C SMARCA2 BCL7B SMARCA4 ZNF765 DNMT3A ZNF317 C19orf84 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 MIB2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRR5 DPY30 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 BRD4 PDCD1 RAC1 COPS5 VAV1 MAPKAP1 IRF1 RPN2 TCF7L2 TUSC3 TCF7L1 RPN1 LEF1 MAGT1 TCF7 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MLST8 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 MTOR TEAD3 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 AKT1 PSMD1 HIF1A ICOSLG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 JAK1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PAK2 RICTOR CUL3 VCP STAT1 MAP3K14 CD28 WDR5 RBBP4 RBBP5 RBBP7 CDK4 PPP2R1B H2AX PPP2R1A PIK3CB H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 AKT2 H3-3B H3C8 H2AC8 H2AC6 PAK3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PDPK1 H2BC15 H2BC11 PIK3R3 KMT2A PIK3CA TRIB3 H3C15 PPP2R5E H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D STAT3 PPP2R5C PIK3R2 H2BC1 PIK3R1 NFKB1 PDCD1LG2 B3GNT3 H2AC20 SPOP THEM4 PTPN11 CDC42 PPP2CA PPP2CB SUZ12 GSK3B CD86 CD80 NFKB2 CSK CD274 MAP3K8 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 WWTR1 YES1 SEM1 LCK FYN SKP1 FOS CUL1 AKT3 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy MAP1LC3A CETN1 FUNDC1 PARK7 ATG5 TOMM20 ATG9A ATG12 ULK1 DYNLL1 TOMM7 ARL13B MFN1 TOMM5 DYNLL2 MFN2 TOMM6 TOMM22 HSF1 IFT88 VCP DYNC1I2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 SQSTM1 PLIN3 DYNC1I1 TBK1 PRKAB2 DYNC1H1 PRKAB1 UBE2D2 UBE2D3 EPAS1 PINK1 USP30 VDAC3 VDAC2 VDAC1 UBE2L3 MAP1LC3B CFTR HSP90AA1 UBA52 HDAC6 PLIN2 TOMM70 UBB UBC DYNC1LI1 PEX5 RPS27A NBR1 DYNC1LI2 UBE2V1 OPTN PRKN HSPA8 CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 UBE2N PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly APOC4 A2M APOC3 APOC2 APOC1 P4HB APOA2 ZDHHC8 APOA1 APOA4 APOB PRKACG PRKACA PRKACB APOE ABCA1 SAR1B MTTP CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling CD86 CD80 PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 RICTOR MAP3K8 PIK3CB MLST8 PIK3CD AKT2 MAP3K14 MTOR LCK CD28 FYN PRR5 PDPK1 AKT1 PIK3R3 PIK3CA MAPKAP1 AKT3 TRIB3 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B1 SLCO1B3 ABCC1 ABCG2 ALB GSTA1 UGT1A4 HMOX1 BLVRB HMOX2 ABCC2 BLVRA UGT1A1 FABP1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B2 SRD5A3 CGA HSD3B1 CYP17A1 HSD11B1 HSD11B2 STARD3NL CYP19A1 POMC CYP11A1 STS SRD5A2 SRD5A1 HSD17B1 CYP11B2 SERPINA6 HSD17B2 CYP11B1 TSPO LHB HSD17B3 HSD17B12 CYP21A2 FDXR STARD3 STARD4 STAR STARD6 AKR1B15 HSD17B14 FDX1 HSD17B11 FDX2 AKR1B1 TSPOAP1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation RPS6KA1 ATF1 MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 RPA1 ERCC8 DDB1 RPA2 XPA POLE4 CUL4A RPA3 PPIE ERCC4 ERCC1 POLE2 POLE3 ERCC5 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGAP32 ROCK1 ROCK2 ARHGAP44 PREX2 ARHGAP40 ARHGDIA HMOX2 STARD8 ARHGAP8 ARHGAP45 AAAS ARHGEF25 CIT IQGAP1 PKN3 PLD1 IQGAP3 STX5 ARHGAP22 ARHGAP20 SRGAP1 STARD13 JUP VMA22 ARHGAP29 ARHGAP24 PKN2 PKN1 ARHGAP31 FAM13A STK10 ARHGAP30 SLK C1QBP ARHGAP9 ARHGAP11B TEX2 ARHGAP4 DDRGK1 TAGAP PLEKHG3 PLEKHG4 BCAP31 ARAP1 GMIP ARHGAP11A TJP2 ARHGAP10 DAAM1 TRIO RASGRF2 PLEKHG6 ARHGEF10L AKAP13 PREX1 STOM MCF2L ARHGEF40 FARP1 VAV3 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 DEF6 VAPB KTN1 ARHGEF15 PLEKHG5 DLC1 TMEM87A DIAPH1 ARHGEF17 FLOT1 ARHGEF19 SCFD1 DIAPH3 FLOT2 ARHGEF18 VAV1 VAV2 ANLN TIAM1 FAF2 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF KALRN RHOA EMC3 CAVIN1 MYO9A ABR RTKN ECT2 ARHGEF28 ARHGAP19 ARHGAP18 MCF2 NET1 RHPN1 RHPN2 ACBD5 MACO1 ARHGAP28 ARHGAP23 FMNL3 ABCD3 SOWAHC DOCK2 TFRC SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP42 OPHN1 STBD1 ARHGDIB LBR TMPO ARAP2 ARAP3 BCR DEPDC1B VAMP3 ARHGAP21 LMAN1 PGRMC2 RACGAP1 YKT6 CAV1 MCAM ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SLC39A2 SLC39A1 SLC39A3 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis IRF1 XIAP IRF2 CYCS CHMP3 CHMP6 TNFRSF10B CHMP7 TNFRSF10A BAK1 GZMB ITCH FAS FASLG RIPK1 OGT CASP1 STUB1 UBE2L3 TRAF2 TNFSF10 HSP90AA1 CDC37 UBA52 BIRC2 FADD ELANE BIRC3 GSDMD GSDME BAX TP63 RIPK3 IL18 IL1A IL1B PELI1 UBB UBC RPS27A CHMP4C CHMP4B CHMP4A PRKN SDCBP MLKL CHMP2B CHMP2A TRADD HMGB1 TP53 CASP8 CASP5 CASP4 FLOT1 FLOT2 CASP3 PDCD6IP ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 SEC22B SERPINA1 SEC23A COPE ARF4 F5 TMED3 F8 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 NSF CTSC CAPZA3 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A TMED2 SPTB DYNC1I1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ANK1 AREG DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 TGFA YKT6 ARFGAP1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RXRA CREBBP CHD9 PPARGC1A NCOA2 NCOR1 NCOA6 TBL1XR1 EP300 SMARCD3 MED1 TGS1 HDAC3 RORC RORA NR1D1 NRIP1 CARM1 TBL1X NCOA1 CPT1A SREBF1 HELZ2 PPARA REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 UBC TICAM2 TICAM1 RPS27A TBK1 TRAF3 OPTN LY96 UBA52 CD14 IKBKE TANK UBB TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation RELA MAP3K7 RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CARD11 IGKV2D-28 MALT1 IGKV4-1 IGHV7-81 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 TAB1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV TRAF6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 PRKCQ UBE2N NFKB1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 V1-11 V1-16 V1-13 CHUK V2-8 IKBKB V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 LYN PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 RASGRP4 CUL1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors LDLRAP1 CUBN AMN APOA2 ACO1 APOA1 ABCD4 APOA4 SLC2A1 PRKG2 PRSS3 LPL LMBRD1 LDLR GPIHBP1 APOC3 LRP8 FLAD1 RFK SLC52A2 APOB SLC52A3 ACP5 SLC52A1 NOS3 ENPP1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR PDZD11 GCHFR GCH1 SPR PTS NNMT PNPO AOX1 NAMPT SLC5A6 ACACA STARD7 FASN COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A SDC4 SDC2 SDC3 SLC46A1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 AKT1 IDH1 COQ2 GSTO1 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC PCCA HLCS MCCC1 PCCB ACACB NUDT12 NADK CYB5R3 THTPA TCN1 NMRK2 NMRK1 RBP4 NAXE RBP1 LRAT NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MOCOS MMAB SLC22A13 QPRT SHMT2 MTRR SLC25A51 SLC25A19 CD38 GPHN HSP90AA1 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 NMNAT1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 TCN2 CD320 AKR1C1 TTR CBLIF AKR1C4 MMACHC MMADHC PLB1 BST1 VNN1 HSPG2 APOE GSTO2 AGRN APOC2 ABCC1 MTR SLC2A3 CALM1 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 BCO1 VKORC1 AKR1B10 NAPRT CLPS RBP2 LRP10 LRP12 PNLIP PDXK NADK2 RDH11 AKR1C3 SLC5A8 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation YARS1 EEF1E1 KARS1 EPRS1 NARS1 IARS1 PPA1 TARS1 AARS1 CARS1 HARS1 FARSA FARSB RARS1 LARS1 AIMP1 AIMP2 WARS1 QARS1 MARS1 GARS1 DARS1 SARS1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP9 DUSP4 TYK2 DUSP6 DUSP7 DUSP10 IL6R CDK1 IL6 PEA15 MAPK1 DUSP5 DUSP2 DUSP1 JAK2 DUSP16 JAK1 MAP2K1 MAP2K2 MAPK3 PTPN11 DUSP8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 SLC19A3 SLC19A2 THTPA TPK1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA1 GRIA2 GRIA3 GRIA4 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C CDK2 MDC1 CLSPN SUMO2 UBE2I RNF4 RNF168 NSD2 PIAS4 BRCC3 UBA52 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN UBB TOPBP1 SIRT6 ATRIP BARD1 RFC5 UBC RMI2 H2BC26 RFC3 RFC4 RPS27A H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB DCP1A ZFP36L1 EXOSC7 EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway CHST8 CHST10 FUT3 FUT8 MAN2A2 CGA MAN2A1 LHB MGAT2 FUCA1 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion F9 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development ROBO2 WFDC2 MECOM GFRA1 OSR1 GATA3 HOXA6 BMP4 PAX8 PLAC8 FOXC2 ITGA8 CTNNB1 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 GREM1 SALL1 SIX2 EYA1 FGF2 HOXB4 IRX1 ID4 LFNG IRX2 JAG1 SLIT2 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 POU3F3 WNT4 WNT11 ITGB1 EMX2 PCDH19 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 CLTC CLTB FZD5 WNT5A AP2S1 ROR1 CLTA ROR2 AP2A1 AP2A2 AP2B1 AP2M1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils PXDN LOXL1 PCOLCE LOXL2 TLL2 TLL1 LOX LOXL3 LOXL4 BMP1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAH SFN YWHAZ YWHAE PDPK1 AKT1 AKT2 YWHAQ CAV1 YWHAG YWHAB AKT3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility ITGA3 CRK LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 RAP1B RAP1A ITGA2 MET DOCK7 RAPGEF1 TNS4 TNS3 SRC RAC1 GAB1 HGF PTK2 CRKL ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 HBB APOA1 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 BACH1 CLOCK NPAS2 TLR4 HELZ2 RAI1 CREBBP CHD9 MAFK NCOR1 SLC46A1 MEF2C TBL1XR1 NFE2L2 EP300 LY96 CLEC1B MED1 TGS1 MEF2D PGRMC2 APOB HBA2 RORA HMOX1 SIRT1 XPO1 PPARA CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway CDC42 LCK CD28 RAC1 FYN CD86 CD80 PAK2 VAV1 PAK1 PAK3 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 ARPC1A LDLRAP1 AP2M1 BIN1 STAM2 ARPC4 STON1 GPS1 ARPC5 STON2 ARPC2 ARPC3 SNX18 COPS4 ACTR3 ACTR2 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 CTTN SGIP1 AP2S1 AGTR1 DNAJC6 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 HIP1R AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 FNBP1L SNX9 APOB SNAP91 M6PR SYT2 GAK ARRB1 FNBP1 ARRB2 SCARB2 AMPH PACSIN2 PACSIN3 PACSIN1 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 RAB5B RAB5C TGOLN2 CHRM2 ARF6 HGS RAB5A WASL CD4 GAPVD1 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 TRIP10 DNM1 SLC18A3 DNM2 DAB2 EPS15L1 EPN1 PIK3C2A SYT9 GRK3 PICALM VAMP8 DNM3 IL7R TFRC PIP5K1C CFTR SYT1 IGF2R UBA52 STAM HIP1 OCRL UBB SYNJ2 SYNJ1 UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 HSPA8 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG ARFGAP1 BTC EPGN HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON SPOP ITCH CUL3 KIF7 IHH SMO GPR161 KIF3A PTCH1 GLI3 GLI2 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 ARRB1 PSMD2 RBX1 ARRB2 PSMD3 PSMD1 CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 NUMB PSMD13 PSMA7 PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 PSMC2 ULK3 GRK2 DZIP1 SPOPL REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway FYN SH3KBP1 VLDLR RELN DAB1 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LDLR APOE LIPC LDLRAP1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation RXRA MED19 MED18 SREBF2 MED11 RELA WNT1 NFKB1 MED9 MED29 KLF5 MED28 MED22 TGFB1 MED21 HDAC3 CDK19 CEBPB TBL1X MED13L ANGPTL4 PCK1 NCOA1 LPL EGR2 FABP4 CDK8 NCOR2 NCOR1 TBL1XR1 PLIN1 THRAP3 LEP FAM120B CD36 PPARGC1A NCOA2 NCOA6 NCOA3 CCNC SMARCD3 CCND3 CARM1 ADIPOQ CDK4 MED16 HELZ2 MED15 KLF4 MED17 CREBBP CHD9 MED12 MED14 MED13 TNF MED10 EP300 EBF1 WNT10B NR2F2 ADIRF SLC2A4 MED1 MED30 ZNF638 TGS1 CEBPD MED31 ZNF467 MED8 MED4 MED27 MED6 MED26 MED7 MED23 MED25 CEBPA MED24 MED20 PPARG PPARA DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CREBBP BMAL1 KMT2A CLOCK TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 YAP1 SERPINB13 ABL1 ITCH GPAM ARID2 ESR1 AUTS2 IL2 IL3 TCF3 LDB1 SIN3B DPY30 WDR5 CR1 ELF1 ELF2 SMARCD1 SMARCD2 FOXP3 SMARCD3 CCND3 CCND2 RBBP5 CDK6 BLK SMARCE1 KMT2D H2AX SPI1 PML H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 MYB EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ ZFPM1 H2BC15 PRKCQ TAL1 H2BC11 KMT2A CBFB ITGA2B SOCS4 GATA2 H3C15 OCLN H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 GP1BA SETD1B SETD1A NFATC2 CCND1 SIN3A TJP1 LMO1 YAF2 LMO2 PTPN11 LIFR KCTD6 TNFRSF18 ASH2L TNRC6C MOV10 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 RSPO3 SRC TNRC6A TNRC6B CLDN5 NR4A3 RNF2 PSMD8 PSMD6 CBX8 PSMD7 PHC2 TCF12 MYL9 PHC1 PAX5 PSMD2 CBX4 PSMD3 CBX2 PSMD1 PHC3 ARID1A IL2RA ARID1B GATA1 AXIN1 IFNG CCNH PSMA5 PSMA6 PSMA3 GATA3 PSMA4 THBS1 PSMA1 SMARCB1 PSMA2 LGALS3 UBA52 PSMD12 PSMD11 PCGF5 PSMD14 PSMD13 PSMA7 HIPK2 SMARCC1 SMARCC2 PSMB6 RYBP CDK7 PSMB7 PSMB4 MNAT1 PSMB5 PF4 UBB PSMB2 CSF2 ACTL6A PSMB3 CREBBP UBC PSMB1 RPS27A KAT2B CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 SMARCA2 PSMC4 SMARCA4 ACTL6B PSMC1 CSNK2B PSMC2 TP73 CTSV CTSL CTSK PBRM1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KPNA6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins DEFA5 DEFA3 ART1 DEFA1B PRSS3 PRSS2 CD4 DEFA6 DEFA4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNA6 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor RASGRF2 CAMK2B NRAS CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism MTR MTRR MMAA MMUT MMAB MMACHC MMADHC DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF1 ALYREF DDX39B CPSF3 CPSF2 SRRM1 DHX38 NXF2B SYMPK NXT1 UPF3B MAGOHB EIF4E RNPS1 NUP205 WDR33 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG GALE DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide VCP TCF25 ANKZF1 KLHDC10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism ACADSB ACAD8 MCCC2 ECHS1 ACAT1 MCCC1 BCAT1 SLC25A44 BCAT2 ALDH6A1 HIBADH PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH HSD17B10 DLD GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation OGDH KGD4 GCSH GLDC AMT DLST DLD CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly CEP41 CEP43 IFT172 KIFAP3 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 RPGRIP1L CCT3 PRKACA WDR35 IFT88 SMO TCP1 KIF3A TTC21B WDR19 IFT122 KIF3B MKS1 KIF3C ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CEP97 YWHAE CNGA4 TUBB4B KIF17 BBS5 TUBB4A BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 YWHAG BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B HSP90AA1 ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 HDAC6 RHO RAB11A ATAT1 TTC8 CNGB1 PPP2R1A CPAP DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 PDE6D MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 TNPO1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DDX21 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway UBC TAB3 RPS27A ALPK1 TAB2 MAP3K7 TRAF6 UBA52 UBB TIFA TAB1 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 NGF PLCG1 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events HRAS MAPKAPK3 RALGDS RALB MAPK12 MAPK13 MAPKAPK2 NRAS MAPK14 MAPK11 RALA SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL3 ITGA1 RHOC HSP90AB1 RHOA RHOB ROCK1 ROCK2 PLXNC1 MET SEMA6A PLXNA4 SEMA6D SEMA7A CDK5R1 PLXNB3 TREM2 SEMA3E SEMA4A CDK5 SEMA5A RND1 MYL9 GSK3B TYROBP SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 FARP2 HSP90AA1 ERBB2 CD72 ARHGAP35 PLXND1 CFL1 PTPRC PLXNA1 PLXNB1 TLN1 SEMA4D PAK1 PAK3 LIMK2 RAC1 LIMK1 MYL12B FYN MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 MYH10 PAK2 NRP1 CRMP1 ITGB1 DPYSL4 DPYSL5 DPYSL2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism CYB5B VAPA GAL3ST1 CERK GBA3 GBA2 MFSD2B SMPD3 SMPD2 SPHK1 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLPP3 SUMF1 PLPP2 B3GNT5 PLPP1 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 SGPL1 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG ACER2 HEXB ARSD ACER1 HEXA B3GALNT1 GLB1L3 B3GALT4 M6PR ACER3 GLB1L2 GALC GLA GLB1L GLB1 SPTLC1 ARSB SPTLC2 SPTLC3 ORMDL2 ORMDL3 SPTSSB SPTSSA ORMDL1 VAPB PRKD3 PRKD2 PRKD1 SPNS2 ABCG2 ALDH3B2 ALDH3B1 FA2H DEGS1 DEGS2 SPHK2 SAMD8 SGMS1 ABCC1 SGMS2 OSBP SGPP2 SGPP1 CSNK1G2 KDSR ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CERS3 ST3GAL2 CERS4 ST3GAL3 CERS5 CTSA CERS6 CERS1 CERS2 PPM1L SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 GNAQ GNA15 PLCB3 PLCB1 FFAR1 PLCB2 GNA11 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A3 SLC26A9 SLC26A6 SLC26A11 SLC26A1 SLC26A4 SLC26A7 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly APOC4 APOB APOC1 MTTP P4HB M PHASE%REACTOME%R-HSA-68886.5 M Phase PRKACA YWHAE EML4 CDCA5 NCAPG YWHAG ARPP19 NCAPH ENSA SIRT2 USO1 NCAPD2 TUBB8 RAB2A IST1 VRK1 LEMD2 TUBB8B NUMA1 FIRRM ESPL1 RAB1A RAB1B GOLGA2 FBXO5 BLZF1 KPNB1 SPAST CC2D1B CNEP1R1 PTTG1 MASTL GORASP2 GORASP1 PPP2R2D CHMP4C CHMP4B CHMP4A PRKAR2B PRKCB CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 TUBB PSMB6 CEP131 PSMB7 HAUS4 HAUS3 CSNK1D PSMB4 HAUS6 PSMB5 HAUS5 CSNK1E TUBG2 LEMD3 UBB TUBG1 PSMB2 PSMB3 TUBB6 HAUS2 TUBB3 HAUS1 MZT2B TUBB1 UBC MZT2A PSMB1 NME7 AKAP9 RPS27A CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 ADRM1 CSNK2A1 DCTN3 HAUS8 PSMC5 HAUS7 CSNK2A2 CEP70 PSMC6 CEP72 PSMC3 TUBA4B CEP192 PSMC4 PCNT PSMC1 TUBA4A CSNK2B CEP76 PSMC2 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS KMT5A NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 HSP90AA1 NDC1 RANBP2 SEC13 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 CPAP KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 RCC1 H2BC21 ZW10 MAD1L1 H3-3B CDCA8 H3C8 H2AC8 PMF1 SKA1 H2AC6 SKA2 KIF23 H2AC7 DSN1 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 RCC2 STAG1 H2BC15 NIPBL NDC80 ZWINT STAG2 H2BC11 RAD21 KIF20A KIF18A RPS27 AHCTF1 H3C15 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 H2AC20 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 LPIN1 CENPT LPIN2 DYNC1H1 CENPU LPIN3 NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 TIAM1 RAC1 NTRK2 BDNF CDK5 CDK5R1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 PSEN1 UBB NOTCH2NLA UBC NOTCH2NLC NOTCH2NLB RPS27A MDK JAG2 JAG1 DLL1 NOTCH2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA AREG EGF MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CLIP1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G2D PLA2G2E MBOAT1 PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 ABHD4 PLAAT1 PLAAT3 PLA2G2A PLAAT2 PLAAT5 PLAAT4 PLA2G4A PNPLA8 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 LPCAT3 PLBD1 PLA2G2F REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A11 SLC6A13 SLC6A12 SLC6A1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 LIPC LDLRAP1 UBA52 AP2M1 CUBN AMN APOA1 LSR NPC1 SOAT1 SOAT2 APOE NPC2 CES3 UBB MYLIP NR1H2 APOC4 UBC AP2S1 NR1H3 LDLR RPS27A APOBR AP2B1 APOC1 NCEH1 APOB BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import TOMM20 GFER OTC TOMM7 TOMM5 TOMM6 SAMM50 TOMM22 MTX1 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX19 COX17 ATP5MC1 TIMM50 PITRM1 GRPEL1 GRPEL2 LDHD CYC1 DNAJC19 COA4 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 HSPD1 ACO2 HSCB TIMM17A TIMM17B COA6 SLC25A4 SLC25A6 TIMM23 TIMM22 HSPA9 TIMM21 TOMM70 SLC25A12 PMPCB FXN PMPCA SLC25A13 NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B VPS28 CHMP4A TSG101 VPS37C VPS37D VPS37A VPS37B GABARAP CHMP2B CHMP2A MVB12B EEF1A1 MVB12A UBAP1 UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A RNASE1 CHMP3 ATG12 GFAP ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B HSP90AB1 DYNLL2 HBB TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B LAMP2 ATM MTERF3 WIPI1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates NUDT13 AK1 RRM2 AK2 AK4 NME1 AK5 AK6 AK7 AK8 DCTPP1 AK9 GLRX NME2 NME3 NME4 DCTD TXNRD1 CMPK1 TYMS CTPS2 CTPS1 RRM1 RRM2B DTYMK TXN GUK1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate SRD5A3 MVD DOLK DOLPP1 DHDDS NUS1 DHRSX DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k ALG1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling DUSP6 DUSP7 KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G DUSP8 DUSP9 IQGAP1 MRAS FAM114A2 QKI NF1 KIAA1549 DUSP10 ESRP1 TRIM24 FXR1 FN1 PHB1 AGTRAP MAP3K11 ARAF AP3B1 PEBP1 SHOC2 CSK AGGF1 JAK2 TENT4A DUSP16 MARK3 SPRED3 FGB SPRED2 BRAP SPRED1 FGA VWF KSR1 KRAS PPP1CB FGG PPP1CC BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes ACSS3 CXXC1 AGPAT2 ABL1 KANSL1 KANSL2 KANSL3 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 TADA3 OGT DPY30 WDR5 PSIP1 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA KMT2A H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 SETD1B SETD1A HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 PHF20 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 KAT8 HCFC2 WDR82 PAXIP1 PEX11A AJUBA KAT14 ZZZ3 HCFC1 TADA2A SGF29 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC PHF20L1 NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 BOD1L1 CREBBP MED17 MBIP MED12 TASP1 MED14 DR1 MED13 BOD1 KAT2B KAT2A YEATS2 MED10 MEN1 AKAP8L PAGR1 MED27 KDM6A SIRT1 MED23 MCRS1 MED24 MED20 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED1 CITED2 CITED4 CGA YY1 HSPD1 ERBB2 VEGFA CDKN1A EGFR DEK NPM1 APOE ATAD2 CREBBP YEATS4 NOP2 TFAP2A TFAP2B ESR1 EP300 WWOX MYC TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 KDM5B CGB8 TGFA KIT MYBL2 PITX2 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly APOA1 APOA4 APOB APOE APOC2 APOC3 SAR1B MTTP P4HB APOA2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant F9 F10 F8 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway BAIAP2 ABI2 PIK3R2 PIK3R1 ABI1 NRAS RHOA THEM4 RICTOR ROCK1 ROCK2 PRKACG PRKACA CTNNB1 PRKACB SPHK1 ELMO2 CDC42 MLST8 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 MTOR HSPB1 SHC2 NOS3 PRR5 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA NCF2 KDR CRK NCF4 PTK2B PXN BRK1 HSP90AA1 MAPKAPK2 JUP CTNND1 PLCG1 CTNNA1 SHB CYBB CYBA SH2D2A PIK3CB MAPKAPK3 CDH5 AXL NCK2 NCK1 RASA1 AKT2 MAPK14 PRKCZ MAPK11 PAK1 PAK3 RAC1 HRAS PRKCB WASF3 BCAR1 AHCYL1 FYN VAV3 PDPK1 NCKAP1L WASF1 PAK2 WASF2 PTK2 PIK3CA ITGB3 VAV1 VAV2 CAV1 AKT3 ITGAV TRIB3 MAPKAP1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair PCNA KDM4B ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 CHEK2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 PARP1 H2BC1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MAPK8 MDC1 KDM4A FEN1 SUMO2 UBE2I SUMO1 PAXIP1 SMARCA5 PIAS4 BRCC3 UBA52 PRKDC BAZ1B BAP1 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 APBB1 UBC RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 RPS27A EYA4 PPP5C RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 KPNA2 RAD17 DCLRE1C TP53 CCNA2 RAD1 RIF1 ATM CCNA1 DNA2 POLL NHEJ1 RAD9B RHNO1 POLM TDP2 ATR TDP1 RAD9A POLQ METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors COQ9 DHFR COQ7 COQ6 COQ5 COQ2 COQ4 HSP90AA1 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ACO1 GCHFR GCH1 SPR PTS PRKG2 NOS3 STARD7 AKT1 CALM1 IDH1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells EOMES SOX17 CXCR4 BMP4 PDPN PRDM1 TET2 TFAP2C POU5F1 NANOG NANOS3 CBFA2T2 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism CPOX SLCO1B1 SLCO1B3 ABCG2 UROD GSTA1 UROS ALAS2 BLVRB ABCC2 BLVRA COX15 ALAD FABP1 FECH COX10 PPOX ALAS1 HMBS ABCC1 ALB UGT1A4 HMOX1 HMOX2 UGT1A1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication HDLBP KPNA7 NACA FASN KPNA4 KPNA5 KPNA3 BTF3 RPN2 BAG2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 VCP SPCS2 DNAJA2 PRKG2 SPCS1 OST4 SEC11A RTN3 SEC11C HSPA1B DDOST VIM TMEM258 DAD1 OSTC CANX CALR ACOT2 YBX1 STT3A EIF4E STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 MAP1LC3B KPNA1 XRN1 IPO7 DNAJB11 PABPC1 P4HA1 UBA52 P4HA2 P4HA3 NPLOC4 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UFD1 RRBP1 UBB EIF4E3 UBC DNAJC3 RPS27A EIF4G3 EIF4G2 SUN2 HSPA8 EIF4A2 EIF4A1 HSPA1A KPNA2 EIF4G1 EIF4A3 ATL2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism MAPDA NT5C2 ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling CAPZA1 PRKCSH AGER LGALS3 S100A12 MAPK1 APP S100B SAA1 HMGB1 CAPZA2 MAPK3 DDOST ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria DCXR NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PCNA YY1 RUVBL1 USP7 ERCC6 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ISY1 ACTR5 RAD23A ACTR8 RAD23B UVSSA TFPT LIG1 POLD3 POLD4 POLK POLD1 POLE POLD2 PIAS3 RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 AQR PARP1 ZNF830 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 PRPF19 RBX1 NFRKB CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 CDK7 ELL ERCC3 ERCC2 MNAT1 ACTB UBB ACTL6A UBC RFC5 RFC3 RFC4 DDB2 RPS27A TCEA1 RFC2 RPA1 ERCC8 RPA2 RPA3 PPIE MCRS1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription IRF1 JUN YAP1 H2BC9 H2AZ2 H4C9 H2BC8 RELA H2BC5 H2BC3 STAT3 TCF7L2 H2BC1 NFKB1 TCF7L1 H2AC20 LEF1 TCF7 CTNNB1 STAT1 ATF3 JUND ASH2L MYCN FOSB MYC TEAD1 TEAD2 TEAD3 TEAD4 SUZ12 DPY30 EPAS1 WDR5 HIF1A EED RBBP4 NFKB2 EZH2 RBBP5 RBBP7 H2AX CREBBP H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 NFE2L2 EP300 H3-3B H3C8 H2AC8 WWTR1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS H2BC11 KMT2A H3C15 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism AADAT SLC3A2 ACMSD AFMID SLC36A4 HAAO KYAT1 TDO2 IDO2 IDO1 SLC7A5 KYAT3 KMO KYNU PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease TALDO1 RPIA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW DPM2 PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions ITGB4 DDR2 DRP2 ITGB5 DMD ITGA6 TNC PDGFB TGFB1 ACTN1 ITGA2 HSPG2 UTRN SNTG2 SDC4 SDC2 SDC3 TRAPPC4 SGCE SGCD AGRN SGCA NTN4 SGCB SGCG SNTA1 SGCZ NRXN1 SNTB1 CASK SNTB2 SDC1 PRKCA LAMA5 LAMA2 THBS1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN DAG1 FGF2 PDGFA TTR DTNA DTNB SSPN DDR1 ITGB3 ITGB1 ITGAV DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes KLF4 FOXG1 SMAD2 SMAD4 SMAD3 PCBP4 FOXO1 CDKN1A CDKN1B CCNG2 MSTN FOXO3 FOXO4 GADD45A CAV1 RBL2 BTG1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ZNF420 CREBBP BBC3 BNIP3L PRELID3A PMAIP1 PRELID1 STEAP3 AIFM2 TP53AIP1 TP53INP1 BAX BID TP63 TP73 PPP1R13B TP53 ATM TRIAP1 TP53BP2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome DDX5 ZCRB1 VHL RB1 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism PLPP2 ACER2 PLPP1 ACER1 ALDH3B2 SGPP2 ACER3 SGPP1 ALDH3B1 SGPL1 PLPP3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation SLC26A2 SRD5A3 GALT B3GALT6 B4GALT7 NCAN HEXB HEXA BGN DCN BCAN VCAN GLB1 CSPG5 CSPG4 GALM ADAMTS13 POMT2 POMT1 POMGNT1 B4GAT1 DAG1 PGM1 LARGE1 GALK1 CHSY1 GALE PRELP CHST6 OMD KERA NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 MUC13 CHST14 HSPG2 MGAT2 PAPSS2 MOGS SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B4GALT1 MAN1B1 GPC1 GPC3 GPC2 GALNT12 GPC5 DPAGT1 SEMA5A GPC4 SPON2 SEMA5B GPC6 SPON1 THSD7B MPI ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 EXT1 ADAMTS3 SDC1 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 THSD7A ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 DPM1 ADAMTS12 DPM2 THSD1 DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 NEU1 SSPOP MUC5B MUC20 MUC21 LFNG ST3GAL3 MPDU1 CTSA NUS1 PMM2 GFPT1 DOLK BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DBT DLD ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense UBC GBP1 RPS27A UBA52 GBP2 GBP6 UBE2D2 GBP4 CASP4 CALM3 CALM2 CALM1 UBB DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants FLT3 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels HCN4 HCN3 HCN2 HCN1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 NEURL1B GZMB UBA52 HES5 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 UBB RBPJ NOTCH2NLA UBC NOTCH2NLC MAML2 NOTCH2NLB MAML1 FCER2 RPS27A MDK EP300 JAG2 JAG1 DLL1 MAML3 NOTCH2 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 HDAC2 KAT8 KDM5B SUZ12 KAT14 SETDB1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SMARCB1 AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 SMARCA2 SMARCA4 KDM6A DNMT3A PBRM1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM SLC34A2 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation HBA2 HBB RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway UBA3 UBE2M CHUK TNFRSF18 RELB MAP3K14 PSMD8 PSMD6 TNFRSF6B PSMD7 EDA TNFRSF13B PSMD2 TNFRSF11B EDA2R PSMD3 TNFSF13B TNFRSF1A PSMD1 TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 PSMA5 TNFSF15 PSMA6 CD70 TRAF2 PSMA3 TNFRSF9 EDAR PSMA4 PSMA1 TNFSF6 TNFSF4 PSMA2 LTA TRAF3 CD27 TNFRSF12A TNFSF9 TNFRSF25 UBA52 BIRC2 TNFSF12 TNFRSF13C TNFSF8 BIRC3 PSMD12 TNFRSF11A PSMD11 CD40LG LTBR LTB PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 TNFRSF1B RPS27A TNF FBXW11 TNFSF13 TNFRSF14 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 APOD SLC27A4 LCN12 LCN1 SLC27A6 LCN9 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 OMA1 PHB2 YME1L1 EIF2AK1 DELE1 EIF2S2 EIF2S1 EIF2S3 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 FURIN IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 SPCS3 ISG15 SPCS2 MED13L SPCS1 CD209 SEC11A SEC11C CDK8 IRF3 IFNAR1 MAVS RIGI TLR2 HSP90AA1 EGFR CD14 RAB5B RAB5C BECN1 TLR7 RAB5A KPNB1 PPP1CC TLR4 BCAP31 STAT2 EP300 LY96 MED1 MED30 MED31 MED8 MED4 MED6 MED7 H2BC15 UBE2L6 HERC5 HSP90AB1 HSPG2 SDC4 SDC2 SDC3 AGRN TLR3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TLR6 ELOB XPO1 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 PPP1CA IFIH1 JAK1 PPP1CB UBB MED16 MED15 CREBBP MED17 UBC MED12 TYK2 MED14 MED13 RPS27A NCL MED10 HSPA8 CUL5 CSNK2A1 CSNK2A2 CSNK2B MED27 MED26 MED23 IGF1R MED25 IFNA5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 CUBN CBLIF AMN LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs FLT3 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBIN HSP90AA1 ERBB2 CDC37 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 GNB5 GNGT1 CCT2 GNGT2 CCT3 TCP1 CCT6B CCT7 GNA14 GNG3 RGS9 GNA15 RGS6 RGS7 GNG2 GNG5 GNG4 GNG7 CSNK2A1 GNA11 GNG8 CCT8 CSNK2A2 CCT5 CCT4 CSNK2B RGS11 GNG10 GNG12 GNG11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER PCNA UBA52 UBB LIG1 UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLE2 POLE3 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 YAP1 HBEGF STAT5A GFAP SPARC STMN1 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 APOE ADAP1 CSN2 NCOR1 CXCL12 MXD4 ESR1 WWOX ADAM17 SRC NRG1 S100B TAB2 EREG NRG3 PGR NRG4 NRG2 BTC ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System YAP1 SEL1L RELA ERLIN1 ERLIN2 ITCH KLC1 RNF185 KLC4 KLC3 KLC2 IFI30 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 KIF5B KIF5A HLA-DOA HLA-DOB LAG3 CTSO CTSF CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG EED RNF111 UBE2V2 RAC1 PRKCB PRKCQ COPS5 UBE2N VAV1 MAPKAP1 NEDD4L CD81 V2-11 DCTN6 V3-4 DCTN5 V3-3 V2-17 DCTN1 DCTN4 V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 CAPZA3 CAPZA2 ACTR10 SOCS1 CD19 IKBKB V2-8 V1-20 MYD88 ASH2L V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 TEAD2 UBE2D2 TEAD3 UBE2D3 TEAD4 ELOB V4-6 ELOC V4-2 RBX1 V4-1 EPAS1 CUL2 HIF1A VHL ICOSLG WWP1 FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B CTSB FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 XDH SIGLEC9 SIGLEC5 WDR5 SEC13 RNF34 RBBP4 RBBP5 PTPRC RBBP7 ITGB2 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 PTPRJ KIF2A ACTR1B CTSH CD33 EVL CTSC KIF2C KIF2B CHUK DYNC1I2 CDC42 PPP2CA KCTD6 PPP2CB LILRA3 DYNC1I1 DYNC1H1 LAIR1 SMURF1 LILRB2 CENPE LILRB3 CD300A OSCAR TYROBP SELL NFKB2 CSK FGB FGA CD274 FGG SYK LCK FYN SKP1 CUL1 CLTC CLTA AP2A1 AP2A2 AP2M1 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 VASP IGHM SH3KBP1 IGHV4-34 IGHV1-2 ITK IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 IGLC3 TRAV29DV5 TRBV7-9 BLNK GRAP2 TRBC1 IGLC1 IGLC2 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 IGKV3D-20 IGHD TRAV19 HLA-DRB4 FYB1 IGKV2-30 ENAH IGLV3-19 HLA-DPB1 IGHV2-70 TRAV8-4 IGHV2-5 HLA-DRA IGLV3-1 LCP2 IGHV3-48 HLA-DRB3 IGLV3-25 HLA-DRB1 IGLV3-27 IGKC HLA-DQB2 IGKV1-39 LAT IGLV3-21 CD101 IGKV1-33 HLA-DQB1 FCGR3A BRD4 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDCD1 PPP3CA PPP3CB LRR1 CCNF UBE2L6 CBLB HERC5 PPP3R1 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 FBXO9 NFATC1 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 DNM2 RNF217 PRKAA1 ATG7 PRKAA2 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 JUND CD207 CALR FBXL4 MLST8 DZIP3 RNF220 FOSB DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 LRRC41 MTOR VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 NCF1 KBTBD6 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 ACTR1A RNF19B UBE3A UBE3B FBXO21 NEK2 UBE2Z FBXO22 NFATC3 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 TRAIP RAB7A RNF41 KLHL42 UBE2V1 DCTN2 CUL7 CUL5 UBA7 UBA6 DCTN3 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 PAK2 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 CARD11 MALT1 ASB13 ASB14 ASB11 RNF6 ASB12 MAP3K14 RNF7 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 PAG1 WAS KIF23 PAK3 COLEC12 KIF20A ITGAV ITGB5 PDCD1LG2 B3GNT3 SPOP SUZ12 DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 GSK3B CD36 KLRK1 NCR2 BCL10 KIR2DS2 CD300LB TREM1 CD300E MAP3K8 KLRD1 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 TAB2 FOS NFKBIB AKT3 JUN PTPN22 CD209 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 UBE2L3 CD14 TLR4 LY96 HMGB1 IRF1 RPN2 TUSC3 RPN1 MAGT1 FBXL18 FBXL7 DNM1 OST4 LGMN DDOST TMEM258 DAD1 OSTC CANX STT3A STT3B KEAP1 DNM3 RNF123 LYN INPP5D PIK3CG PIK3R6 PIK3R5 SIAH2 BTK ARF1 CD40LG JAK1 TRIM4 IKBKG RIPK2 OSBPL1A PIK3CD PRKN CAPZA1 PSME2 PPIA AHCYL1 MAP3K7 VCP CXADR SMURF2 NFKBIA PTEN CD74 JAML CD99 TRAF6 BECN1 PIK3CB CAPZB NCK1 AKT2 CTSD HRAS PDPK1 PIK3CA PIK3R3 PIK3C3 TRIB3 SOS1 SH3RF1 PIK3R4 PIK3R2 PIK3R1 NRAS THEM4 PTPN11 ZAP70 CALM1 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 SEM1 KIF5C KIFAP3 HSPA5 KIF3B KIF3C KIF4B KIF4A TLR1 KIF11 S100A9 S100A8 KIF15 TLR2 KIF22 STX4 CD4 KIF26A TCF7L2 TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ATF3 TREM2 TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 SPTBN2 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CTLA4 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 C3 RICTOR CUL3 STAT1 KIF3A VCAM1 RBBP6 AP1G1 AP1S2 AP1S1 ITGB7 AP1S3 B2M AP1M2 AP1M1 AP1B1 TRIM32 HLA-A TRIM21 CD8B CD28 NEDD4 MKRN1 PLCG1 FZR1 SKP2 CDK4 BLK H2AX H2AB1 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 FBXO32 H2BC1 NFKB1 H2AC20 ITGAL MYLIP TRIM63 ITGA4 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 NCR3 CD200R1 HCST LILRA6 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 CD8A KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 FBXL21P WWTR1 CTSA YES1 CTSV CTSL CTSK DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 IL6 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 IL6R RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway DUSP9 DUSP4 PPP2R5B PPP2R5A DUSP6 PPP2R5D DUSP7 PPP2R5C DUSP10 NRAS UBA52 MAPK1 ARAF PEBP1 RAF1 DUSP16 MARK3 BRAP MAPK3 KSR1 BRAF UBB PPP2R1B PPP2R1A PTPN3 PTPN7 PPP2CA PPP2CB UBC RPS27A PPP5C PAQR3 YWHAB HRAS DUSP5 DUSP2 DUSP1 MAPK12 MAP2K1 MAP2K2 PPP2R5E DUSP8 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling IKBKB UBC TRAF2 RPS27A LRRC14 NLRX1 NLRC5 TRAF6 UBA52 USP14 CHUK TP53 CASP8 USP18 IKBKG UBB IKBIP MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 CPSF4 CPSF7 CPSF1 FUS CPSF3 CPSF2 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 CDC40 DHX9 CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 SYMPK RBM10 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants KIT CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression FASN MLX AGPAT1 ACACA ACLY MLXIPL ACACB EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells CLTC CLTB TIAM1 CLTA AP2A1 EPHB6 EFNB2 AP2A2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 AP2M1 EPHB3 APH1A PSENEN EFNA5 NCSTN EFNA4 APH1B PSEN2 CLTCL1 ADAM10 PSEN1 DNM1 EFNA1 EFNA3 EFNA2 MMP9 AP2S1 MMP2 EPHA2 AP2B1 EPHA5 EPHA4 EPHA7 YES1 EPHA6 RAC1 EPHA8 FYN VAV3 EPHA1 EPHA3 EPHA10 VAV2 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding NTHL1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2BC9 H4C9 H2BC8 H2BC5 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 H2AC1 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 SUZ12 H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 TRIM28 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 RBBP4 EZH2 DAXX NUP37 RBBP7 CBX1 PML H2AC19 H2BC26 DYNC1LI1 H2AC14 DYNC1LI2 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ELK1 ITGB1 H3C15 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type MMAA MMUT IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs IFNG MAPK1 RAF1 JAK2 JAK1 MAPK3 IFNGR1 IFNGR2 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n RFT1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SNAP25 RAB3A ARL6IP5 STX1A SYT1 SLC1A6 GLS2 SLC1A7 VAMP2 CPLX1 RIMS1 UNC13B GLS SLC38A2 PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC17A7 SLC1A1 TSPOAP1 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 RXRB NRIP1 PCK1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway CYP26A1 CYP26B1 CYP26C1 ADH1C DHRS4 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 ALDH8A1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN YES1 HCK SYK FYN ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A8 SLC22A12 SLC22A11 SLC22A7 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOF APOB LPA CETP MTTP P4HB SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea CACNA1D CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 TMIE USH1G STRC MYO15A CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation REXO2 FASTKD5 TBRG4 SLIRP PNPT1 FASTKD2 LRPPRC GRSF1 SUPV3L1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 DYNLL1 DCTN6 DCTN5 ACTR1A DCTN1 DYNLL2 PAFAH1B3 DCTN4 RAB6A CAPZA3 CAPZA2 PAFAH1B1 DYNC1I2 GALNT1 ACTR10 PLA2G4A CAPZB DYNC1LI1 DYNC1I1 RAB6B GALNT2 DYNC1LI2 DCTN2 DYNC1H1 CAPZA1 DCTN3 RAB3GAP2 PAFAH1B2 RAB3GAP1 BICD1 RAB18 BICD2 AGPAT3 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation YARS1 YARS2 NARS1 NARS2 RARS2 CARS1 CARS2 VARS2 MARS2 DARS2 RARS1 SARS2 LARS1 AIMP1 AIMP2 IARS2 QARS1 WARS1 WARS2 MARS1 DARS1 SARS1 EEF1E1 PARS2 KARS1 EARS2 LARS2 EPRS1 IARS1 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 FARSA FARSB FARS2 GARS1 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions CNTNAP1 CNTN1 NRCAM ANK1 SDCBP NFASC DCX TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 HMMR DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TPX2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED BTRC RBBP4 RBBP5 RBBP7 CDK4 H2AX H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DBT DLD DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA PAN3 PAIP1 PABPC1 PARN CNOT4 CNOT6 CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT6L CNOT11 EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 EIF4A3 PAN2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC LDLRAP1 PCCA HLCS CUBN MCCC1 AMN PCCB ACACB NUDT12 ABCD4 NADK SLC2A1 CYB5R3 PRSS3 THTPA TCN1 NMRK2 NMRK1 LMBRD1 NAXE NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MMAB MOCOS FLAD1 SLC22A13 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 QPRT SHMT2 MTRR SLC25A51 PARP10 PARP6 SLC25A19 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR CD38 GPHN PDZD11 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 DCAKD NMNAT1 COASY PPCDC SLC25A16 NUDT8 VNN2 NNMT PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 PNPO AOX1 TCN2 NAMPT CD320 SLC5A6 ACACA CBLIF MMACHC MMADHC FASN BST1 VNN1 GSTO2 SLC46A1 ABCC1 MTR SLC2A3 NAPRT PDXK GSTO1 NADK2 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L SLC5A8 MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP7 PIK3R4 FURIN DDX5 RB1 BECN1 HSPG2 VCP TMPRSS2 SDC4 SDC2 SDC3 AGRN ACE2 CHMP4C CHMP4B GPC1 CHMP4A ZCRB1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 CHMP2B CHMP2A NRP1 SDC1 CTSL VHL PIK3C3 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ILK PARVA ITGB1 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration ACO1 IDH1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes PRDX2 CYCS PRDX1 COX5B COX5A COX6C COX4I1 COX4I2 COX6A1 PRKAA1 COX6A2 PRKAA2 MT-CO1 PRKAG1 G6PD PRKAG2 PRKAG3 RPTOR COX6B2 COX6B1 COXFA4 TNRC6C MLST8 COX7A2 MOV10 RRM2B COX7A1 SLC38A9 HIGD1C AGO3 AGO4 PRKAB2 AGO1 TSC2 AGO2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC YWHAE MT-CO2 PTEN SESN3 MT-CO3 RHEB RRAGB SESN2 RRAGD LAMTOR2 AKT1 LAMTOR1 LAMTOR4 YWHAQ LAMTOR3 LAMTOR5 YWHAG GPX2 YWHAH GPI YWHAZ SFN GLS2 GLS TIGAR TP63 TXNRD1 AKT2 COX7A2L COX7B TP53 COX7C TXN COX8A COX8C AKT3 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CCNH PLK1 CCNB1 CDC25C CDK1 CDC25B FZR1 CDC25A CDK2 CDK7 MNAT1 PPP2R1B PKMYT1 PPP2R1A FOXM1 PPP2CA WEE1 HJURP PPP2CB PPP2R2A SGO1 PPME1 BORA OBI1 MIS18BP1 LCMT1 PPP2R3B TICRR XPO1 CCNB2 CCNA2 CCNA1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 F3 TFPI SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation ACD TINF2 TERF1 TERF2 POT1 TERF2IP STN1 TEN1 CTC1 PRIM2 PRIM1 POLA1 POLA2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB3 KCNN2 KCNMA1 KCNMB4 KCNN1 KCNN3 KCNN4 KCNMB1 KCNMB2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses PTPRS EPB41L3 HOMER3 NTRK3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN RTN3 LRFN3 APBA3 PTPRD APBA2 LRFN2 LRFN4 EPB41L1 LRFN1 STX1A SHARPIN LRRC4B SYT9 GRIA1 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 IL1RAPL2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 DLG1 CASK NRXN2 GRIN2A LIN7A SLITRK2 DLG2 LIN7C SLITRK1 DLG3 SLITRK4 LIN7B SLITRK6 DLG4 PDLIM5 GRIA3 NLGN4Y GRIA4 NLGN4X SYT10 SYT12 APBA1 SYT1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DBNL IL1RAPL1 PTPRF GRM1 GRM5 SLITRK3 SLITRK5 FLOT1 FLOT2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism MCCC2 BTD PC ACACA PCCA HLCS MCCC1 PCCB SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins PIAS4 NFKB2 RELA EIF2AK2 PIAS3 SUMO3 IKBKE NFKBIA UBE2I SUMO1 IKBKG TOPORS UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins HBEGF SNAP25 HSP90AA1 FURIN SYT1 CD9 HSP90AB1 SV2C SV2B SV2A TXNRD1 VAMP1 MAP2K4 STX1A VAMP2 MAP2K7 EEF2 STX1B GUCY2C SYT2 NHERF4 MAP2K1 MAP2K2 CALM1 PDCD6IP DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 NEU1 ALG14 ALG2 ALG3 B4GALT1 ALG13 ALG12 MAN1B1 ALG11 ALG1 MPDU1 DPAGT1 CTSA RFT1 MGAT2 MOGS GLB1 ALG8 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis CSPG4 HSPG2 SDC4 SDC2 SDC3 B3GAT3 XYLT2 AGRN XYLT1 B3GALT6 B4GALT7 GPC1 FAM20B UXS1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 PXYLP1 B3GAT2 B3GAT1 BGN DCN BCAN VCAN SDC1 CSPG5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed SENP5 SUMO3 SENP1 SUMO2 SENP2 SUMO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C8G C5 C6 C7 CLU C9 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism SLC26A2 SLC26A11 SLC26A1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 GNS HAS2 SPAM1 B4GALT6 B4GALT5 B3GALT6 B4GALT7 IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB SLC35B3 B4GAT1 SLC35B2 XYLT2 SLC35D2 XYLT1 FAM20B CHPF PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 B3GNT3 CHST14 HSPG2 PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 ACAN SDC2 SDC3 LUM HS6ST1 B3GAT3 HS6ST2 SGSH CD44 HS2ST1 HS6ST3 NDST2 AGRN NDST1 FMOD EXTL2 NAGLU B4GALT1 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DSEL DSE UST CHST15 ABCC5 ST3GAL4 SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 HMMR ST3GAL2 ST3GAL3 SLC9A1 CTSL CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer HBEGF RAC2 RHOG NTRK3 PIK3R2 NTF3 PIK3R1 PDGFB FGF20 FGF23 MET FGF22 PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 ESR1 ESR2 SRC NRG1 CD28 PIK3AP1 CD86 CD80 ERBB2 EGF PIK3CG EGFR TRAT1 PIK3R6 PIK3R5 KLB FLT3 IRS1 IRS2 PIK3CB STRN FGF1 FGF2 FGF3 PIK3CD AREG FGF4 FGF6 FGF7 FGF9 PDGFRA RAC1 LCK FYN PDGFRB NTF4 NTRK2 BDNF KIT TGFA GAB1 FLT3LG FRS2 HGF GAB2 EREG NRG3 PIK3CA PIK3R3 NRG4 NRG2 VAV1 BTC EPGN NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM SAMHD1 PNP ITPA NT5E ENTPD1 ENTPD5 ENTPD2 ENTPD3 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP3 CHMP6 CHMP7 UBA52 STAM STAM2 HGS VPS36 VPS25 UBB SNF8 UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer SOS1 UBC HBEGF RPS27A HSP90AA1 SHC1 AREG EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN UBB SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE TLR3 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport CYGB MB NGB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses GJA10 PANX1 PANX2 GJD2 GJC1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX ANAPC16 ANAPC7 UBE2C CSF1R VENTX UBE2E1 UBE2D1 RELA ANAPC10 ANAPC11 TCF7L2 CDC23 NFKB1 UBE2S CDC26 CDC27 CDKN2A LEF1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 CCND1 ANAPC2 CTNNB1 CEBPB EHMT2 EHMT1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B IL6 TP53 ANAPC15 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 FGF18 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FGF16 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport TRAPPC6A TRAPPC6B PREB SEC22A SEC22C STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 CTSZ NSF CTSC COL7A1 SAR1B SEC31A TRAPPC4 TMED10 SEC22B TMED2 SERPINA1 SEC23A GRIA1 CD59 F5 TFG F8 SEC24B SEC24A STX5 USO1 ANKRD28 SEC13 PPP6C PPP6R3 NAPA NAPB SEC24D RAB1A SEC24C RAB1B TRAPPC1 GOLGA2 NAPG CSNK1D GORASP1 AREG TRAPPC2L LMAN1L GOSR2 LMAN1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 TGFA SEC16A TRAPPC5 TRAPPC9 YKT6 CNIH1 CNIH2 SCFD1 CNIH3 MCFD2 PPP6R1 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME CYP2E1 ABCG2 GSTT1 GSTM1 ABCC2 GGT5 NAT1 GGT7 NAT2 SULT1A1 GGT6 ABCC5 CNDP2 SULT1E1 SULT1A4 ABCC3 GGT3P UGT1A10 GGT1 ABCC1 SULT1C4 ACY1 SULT2A1 GSTP1 ABCC4 SULT1A3 UGT1A6 UGT1A1 UGT2B15 UGT1A9 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling CSF3 STX4 TYK2 TXLNA CSF1R SNAP25 STX1A IFNLR1 STXBP2 VAMP2 IL34 IL16 PRTN3 IFNL1 SDC1 JAK1 PTPRZ1 IL32 CD4 STX3 IL10RB CSF3R CSF1 CASP3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 INS KIF5C SLC30A8 PCSK1 SLC30A5 STX1A KIF5B KIF5A MYO5A RAB27A VAMP2 MYRIP P4HB PCSK2 ERO1B EXOC8 CLTRN EXOC7 CPE DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 SPAM1 ZP1 B4GALT1 ZP3 ADAM21 ZP2 ADAM20 ZP4 OVGP1 ADAM30 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2E1 PTGR1 ALOX5AP CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions RPS6KA1 CLTC CLTA AP2A1 ITGA1 AP2A2 AP2M1 CNTN1 AP2S1 KIF4B AP2B1 KIF4A NCAN RPS6KA6 LAMA1 EGFR LAMB1 LAMC1 SPTAN1 NUMB SDCBP NFASC RAC1 NRP1 MAP2K1 MAP2K2 EZR ITGB3 ITGA2B SPTBN1 ITGB1 L1CAM VAV2 DPYSL2 ITGAV NCAM1 ITGA5 ITGA9 ALCAM SCN11A RDX SCN10A MAPK1 CHL1 ITGA2 LYPLA2 DNM1 DNM2 MAPK3 CNTNAP1 SPTB RPS6KA4 SCN1B SCN1A ANK2 ANK3 SHTN1 DNM3 SPTBN4 DLG1 SPTBN5 SCN3B DLG3 SCN3A SPTBN2 DLG4 CD24 SCN2A SCN2B KCNQ2 KCNQ3 SCN9A EPHB2 SCN8A ITGA10 SPTA1 CNTN6 RANBP9 SCN5A GAP43 DCX SCN4A SCN4B MSN NRP2 SCN7A CNTN2 NRCAM ANK1 SH3GL2 HSPA8 CSNK2A1 CSNK2A2 PAK1 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 PRKACA SLC8A1 SLC8A2 NOS1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D FXYD4 FXYD3 CAMK2A FXYD2 DMPK FXYD1 FXYD7 FXYD6 ATP2B4 RYR1 ATP2B3 RYR2 ATP2B2 RYR3 ATP2B1 TRPC1 SLC8A3 CLIC2 CALM1 CAMK2G TRDN ASPH ATP1A4 ATP1A3 ATP1A2 TNNI3 ATP1A1 PLN FKBP1B AHCYL1 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 OGG1 NEIL2 POLB LIG3 NEIL1 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation GP5 GP9 F9 GP1BA GP1BB F11 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PRKCA GFRA1 SOS1 GFRA3 GFRA2 SHC1 GFRA4 MAPK7 PIK3R2 PIK3R1 NRTN PLCG1 DOK2 DOK4 DOK5 DOK6 RAP1GAP PRKACG PRKACA PSPN PRKACB GDNF RET PTPN11 IRS2 PIK3CB PDLIM7 PIK3CD DOK1 GRB10 SHANK3 SHC3 GAB1 FRS2 GRB7 GAB2 PIK3R3 PIK3CA ARTN G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG GIP PRKACA PRKACB ADRB2 PTGIR AVPR2 GNAZ LHB PDE1B ADORA2B GNG3 PDE1A GNG2 RXFP1 GNG5 RXFP2 GNG4 GNG7 PDE11A GNG8 PDE2A ARRB1 ARRB2 PTH1R GPR39 PDE10A PTH2R GPHA2 GNAS NPSR1 CRH NPS GPHB5 LHCGR RLN2 RLN3 P2RY11 GCGR GCG INSL3 GPR84 PTH2 CRHR1 CYSLTR2 RAMP2 CALCA MC1R RAMP3 CALCB PDE3B MC4R CALCR CALCRL GPBAR1 MC3R ADM2 ADM IAPP FSHR GRK5 RAMP1 PTH MC5R PRKAR1B PRKAR2B PRKAR1A PRKAR2A ADRB1 HTR4 ITGB1 GPER1 HTR6 TAAR3P ITGA5 HTR7 CGA HRH2 DRD1 DRD5 PTHLH TAAR8 TSHR TAAR9 TAAR6 GNAT3 TAAR5 TAAR2 FSHB TAAR1 ADRB3 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PDE3A PDE8B PTGER4 PDE8A GRK3 GRK6 SRC ADCYAP1 PTGER2 ADCYAP1R1 PTGDR PDE4A PDE4D PDE4C GNAI3 ADORA2A GNAI1 GNAI2 PDE7B PDE7A CRHR2 TSHB POMC GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP AVP GRK2 GNG10 MC2R GNG12 GNG11 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) STAT5A STAT5B UBE2D1 SHC1 LYN STAT3 GRB2 UBA52 JAK2 JAK1 STAT1 KRAS SOCS1 UBB PTPN11 CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC GAB2 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNQ1 KCNE5 AKAP9 KCNH2 KCNE1 KCNA5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 FGF6 FGF9 PLCG1 FGF20 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 PPP2CA PPP2CB CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C AKT2 CTLA4 YES1 LCK FYN AKT1 PTPN11 PPP2R1B PPP2R1A PPP2R5E AKT3 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels STIM1 P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 P2RX4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling FGF2 TGFBR3 GIPC1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB ENSA MASTL PPP2R2D CCNB1 PPP2R1B CDK1 PPP2R1A ARPP19 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 SFTPD IL17RC IL17RA NLRP12 YWHAQ IL17F IL17A YWHAG GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 STAT2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E IKBKB YWHAB TRIM25 IKBKE AKT1 IRF7 NUP214 SFN YWHAZ IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C NUP42 NUP85 TPR NUP62 UVRAG NUP88 MAP1LC3B NUP43 RAE1 HSP90AA1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 NOD1 NOD2 AKT2 PDPK1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 TJP1 CHUK PTPN11 SIKE1 CREBBP PTPN6 IRAK2 SNRPG TAB3 TAB2 SNRPE IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria KHK MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT11 ACADL ACOT12 HADHB ACOT13 HADHA ACADVL ACADM ACSM3 ACADS PCCA ECI1 THEM4 PCCB ACSM6 THEM5 ACAD11 NDUFAB1 ACAD10 MCAT ACBD7 ACBD6 ACOT7L ACSF2 MCEE ACOT2 DBI PCTP ECHS1 DECR1 ACOT9 ACOT7 MECR ACAA2 MMAA MMUT HADH ACOT1 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 LMNB1 UBE2I TEX12 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B REC8 SYCP3 BRCA1 STAG3 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L H2BC21 SUN2 SUN1 H2AC8 H2AC6 H2AC7 H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 STAG1 H2BC11 STAG2 RAD21 ATR DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis RIPK1 TRADD TRAF2 RIPK3 CASP8 FADD MLKL DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) RELA NFATC1 MAP3K7 NFKB1 NRAS RASGRP1 NFATC2 CHUK IKBKB CARD11 MALT1 NFKBIA FKBP1A PSMD8 PSMD6 PSMD7 RASGRP3 PSMD2 REL NFKBIE PSMD3 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PPIA PSMC5 PSMC6 HRAS PRKCB SEM1 PSMC3 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB SKP1 NFKBIB PPP3R1 CUL1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2BC9 H2AZ2 H4C9 H2BC8 PIWIL2 H2BC5 TDRKH H2BC3 PIWIL1 HENMT1 H2BC1 ASZ1 MAEL MOV10L1 MYBL1 H2AC20 TDRD9 TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 DGCR8 TNRC6C TSNAX AGO3 PRKRA DICER1 AGO4 TARBP2 TSN AGO1 AGO2 TNRC6A TNRC6B POLR2A POLR2B POLR2C HSP90AA1 POLR2D POLR2E RAN POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L IPO8 ELAC2 H2AX H2AB1 H2AC19 H2BC26 ANG H2AC14 BCDIN3D H2BC12L XPO5 H2BC21 DROSHA PIWIL4 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 POU3F2 TNRC6C MOV10 AGO3 DICER1 AGO4 HDAC1 TRPM1 AGO1 AGO2 TNRC6A TNRC6B HINT1 BIRC7 BCL2A1 SIN3A PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 PLCG1 FGF20 FGF23 KLB FGF16 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs MAP1LC3B ULK1 RAB8B RAB33B RAB33A TBC1D2 RAB5B RABEP1 RAB5C TBC1D3 TBC1D7 RAB7B RABGAP1 RAB11A RAB6A ARF6 RAB4A RAB11B RAB5A RABGEF1 TBC1D10A TBC1D10B GABARAPL2 SYTL1 RAB7A RAB6B RAB35 GGA2 TBC1D24 GGA1 TBC1D25 OPTN GGA3 TSC2 RAB8A TSC1 TBC1D20 GABARAP TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 TBC1D10C CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC2A6 SLC2A7 SLC5A1 SLC2A8 SLC5A2 FGF21 SLC50A1 SLC2A4 SLC2A9 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A10 SLC2A11 SLC2A12 SLC5A10 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D GRIN1 RPS6KA6 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 RPS6KA3 RPS6KA2 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion UBC RPS27A FURIN VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A PPIA VPS37B MVB12B MVB12A UBAP1 NMT2 UBB PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG CETP APOA2 APOA1 APOA4 APOA5 APOE ANGPTL8 ANGPTL4 LPA MTTP LPL LMF2 LMF1 APOF GPIHBP1 FGF21 MBTPS1 APOC3 APOC2 ANGPTL3 ALB P4HB ABCG1 MBTPS2 APOB PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL PPP2CA PPP2CB PECAM1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PTPN6 MAPK14 LRP8 APOB PLA2G4A PTPN11 PPP2R1B FGR PPP2R1A PPP2R5E BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 ABCA3 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases RNF128 APC OTUD5 UBE2D1 TRAF3 ZRANB1 TRAF6 UBA52 OTUB1 RHOA CDK1 OTUB2 OTUD7A OTUD7B VCP IFIH1 NOD1 TRIM4 NOD2 VCPIP1 IKBKG UBB RIPK2 RIPK1 UBC RPS27A ESR1 TNIP1 MAVS TNIP2 TNIP3 OTUD3 RNF135 RIGI PTEN TNFAIP3 TP53 TRIM25 YOD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CYP51A1 SREBF2 MSMO1 NSDHL HSD17B7 TM7SF2 SREBF1 DHCR24 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome RELA NFKB1 HSP90AB1 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 PYCARD NLRP3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 PIP4K2C IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport ATP6V0D1 FTH1 ATP6V0C ATP6V0D2 ATP6V1B1 FTL ATP6V1A IREB2 ABCG2 CP FBXL5 ATP6V0A2 CYBRD1 ATP6V1H ACO1 ATP6V0A4 SLC40A1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HEPH ATP6V1F ATP6V1C2 ATP6V0A1 TF SLC46A1 STEAP3 HMOX1 HMOX2 SLC22A17 FTMT MCOLN1 STEAP4 TFRC HFE GLRX3 UBA52 UBB TCIRG1 CAND1 UBC LCN2 RPS27A NEDD8 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 SKP1 TFR2 ATP6V1B2 SLC11A2 CUL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 CRK PXN ARHGAP35 RASA1 NRAS RHOA ELMO1 RAC1 HRAS BCAR1 ELMO2 DOCK1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling CCND1 RUNX3 CTNNB1 TCF7L2 TCF7L1 MYC LEF1 TCF7 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 GRAP2 RICTOR MAP3K8 PPP2R1B PPP2R1A PIK3CB CDC42 PPP2CA PPP2CB MLST8 PIK3CD AKT2 CTLA4 MAP3K14 YES1 PAK1 PAK3 MTOR RAC1 LCK CD28 FYN PRR5 PDPK1 PAK2 AKT1 PIK3R3 PIK3CA VAV1 MAPKAP1 PPP2R5E AKT3 TRIB3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA RPS6KA1 SOS1 CCKBR HBEGF MAPK7 EGFR NRAS MAPK1 HRAS MMP3 MAPK3 GAST RPS6KA3 RPS6KA2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants FZD5 FZD4 WNT3A FZD6 LRP5 RNF43 FZD8 LRP6 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle LIG1 BANF1 XRCC6 FEN1 XRCC4 KPNA1 XRCC5 LIG4 PPIA HMGA1 CCR5 CXCR4 PSIP1 CD4 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E UBC RPS27A UBA52 UBB MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling RANBP10 HRAS SOS1 MUC20 MET RANBP9 HGF NRAS CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA1 NRAS MAPK1 MAPK3 RASGRF2 CAMK2B CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 RPS6KA6 PDPK1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RPS6KA3 CALM1 CAMK2G RPS6KA2 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX10 PPOX ALAS1 CPOX HMBS ABCG2 ALB UROD UROS ALAS2 COX15 ALAD FECH ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase CREBBP HSP90AA1 HSPA8 EP300 HSP90AB1 DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A FKBP4 HSPA1B SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins SOS1 STAT5A STAT5B CDKN1A PIK3R1 NRAS TRIP11 GOLGB1 PIM1 HRAS ZMYM2 GAB2 MYO18A PIK3CA ETV6 NOX4 SPTBN1 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH GNMT DAO PXMP2 GLDC AGXT HOGA1 GOT2 KGD4 GRHPR DDO HAO1 AGXT2 AMT DLST ALDH4A1 PRODH2 DLD FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate POU3F1 PAX6 ZIC2 ZEB2 SOX2 POU5F1 NANOG ZNF521 SOX1 GBX2 OTX2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN RNF146 PSMA5 PSMA6 PSMA3 PSMA4 AXIN2 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 TNKS PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A SMURF2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 AXIN1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT5 NUDT16 NUDT15 ADPRM NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling RGMB RGMA UNC5A UNC5B PLCG1 SIAH2 UNC5C UNC5D PITPNA AGAP2 WASL HJV SIAH1 PTPN11 CDC42 SLIT1 SLIT3 NEO1 DSCAM NTN4 MYO10 DCC DSCAML1 NTN1 TRIO NCK1 SLIT2 ROBO1 SRC RAC1 TRPC7 TRPC5 TRPC6 PRKCQ ABLIM1 TRPC3 ABLIM2 TRPC4 ABLIM3 TRPC1 PTK2 EZR DOCK1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A SS18 SMARCB1 SMARCD1 DPF1 BCL7A DPF2 BCL7C SMARCA2 BCL7B DPF3 SMARCA4 SMARCC1 SS18L1 ARID1A SMARCE1 ARID1B ACTB SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane SRPRB SEC61A2 SEC61A1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TRAM1 RPS3A RPS26 SRP54 RPS25 RPS28 SSR4 RPS29 SSR2 RPS20 SSR3 SRP9 FAU RPS21 RPS24 RPS27 RPS23 SRP72 SRP68 SRP19 RPN2 RPN1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL DDOST RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 SRP14 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 SEC61G RPLP0 SEC61B RPS27A SSR1 SRPRA SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A2 SLC17A1 SLC26A11 SLC4A7 SLC26A1 SLC20A2 SLC4A8 SLC4A10 SLC4A9 SLC26A4 SLC26A7 SLC26A3 SLC26A9 SLC26A6 SLC13A1 SLC13A4 AHCYL2 SLC12A3 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC4A2 SLC12A7 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 SLC12A6 SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC5A5 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin MAOA SLC6A4 ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME MAPDA NT5C2 ABCB1 ADH1A PCK1 ABCG2 SLC22A2 SLC22A3 SLC22A1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism CDA ADSL PPAT GMPS NUDT13 ADSS1 ADSS2 GART PAICS PFAS NT5C DCTPP1 AGXT2 NT5C1A DPYS NME2 DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP RRM1 RRM2B SAMHD1 DTYMK ATIC ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 TK1 ENTPD8 AK1 RRM2 AK2 NME1 AK4 AK5 AK6 AK7 AK8 AK9 GLRX NME3 NME4 DCTD CMPK1 TXNRD1 TYMS CTPS2 MAPDA CTPS1 GMPR2 GDA ADK AMPD1 NT5C2 NUDT5 GMPR DNPH1 AMPD2 AMPD3 NT5C1B NUDT16 DCK NUDT15 APRT ADPRM DGUOK PNP ITPA HPRT1 IMPDH1 IMPDH2 ADA UCKL1 UCK2 UCK1 PUDP TK2 NT5E ENTPD1 ENTPD5 TXN CAD DHODH UMPS GUK1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 STX1A SYT1 VAMP2 SV2C SV2B SV2A VAMP1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival IKBKB SQSTM1 UBC RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR UBB HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 MFN1 MFN2 KLC1 KLC4 IFNA10 KLC3 GUCY1B2 KLC2 GUCY1B1 IFNA21 ATP2A3 ATP2A2 IFNB1 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PLA2G4A FGR STIM1 KCNMA1 ORAI2 SLC16A8 PECAM1 ORAI1 SLC16A3 PDE9A PDE1B PDE1A KIF5B ITPR1 KIF5A ITPR2 SLC16A1 ITPR3 SRI PSAP LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS2 NOS3 PDE2A ATP2B4 VPS45 ATP2B3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 P2RX4 PDE10A P2RX3 CRK P2RX2 P2RX1 GNAS SERPINB8 S100A10 C1QBP CABLES1 RAB5A MMP1 SLC3A2 SLC7A11 EPCAM SLC7A10 PRKCB SERPINC1 RAC1 VAV3 SERPIND1 PRKCQ SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 VAV2 SLC7A9 IRF1 IRF2 NFE2 V2-11 V3-4 V3-3 MPL V2-17 THPO V3-2 V2-15 V2-19 V1-11 GNA13 V1-16 V1-13 CAPZA2 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 TBXA2R V4-6 V4-2 V4-1 SDC1 GATA3 LYN INPP5D PIK3CG PIK3R6 PIK3R5 CFL1 PF4 SERPINB2 ANXA2 MIF SOD1 CAPZA1 AAMP PPIA TUBA4A PRKCG TP53 PRKCE GNG10 GNG12 GNG11 GNG13 ITGA3 GNB2 GNAQ ITGA1 GNB1 MAFG ITGA6 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 WEE1 GNA14 OLR1 SPN VPREB3 VPREB1 GNG3 CXADR CDK5 GNA15 PSG1 PDPN PSG3 MPIG6B GNG2 SERPINB6 CLEC1B PSG2 GNG5 PSG9 GNG4 FCAMR GNG7 PSG8 GNA11 PSG5 GNG8 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 ARRB1 ARRB2 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD SH2B2 ANGPT4 ANGPT2 MERTK CD2 CD244 ITGAM ITGB2 PPP2R1B PPP2R1A PIK3CB CAPZB PRCP PFN1 GATA6 TFPI F13B HRAS PCDH7 ZFPM1 PDPK1 RBSN SIRPG GRB7 KIF18A PIK3CA PIK3R3 ITGB1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 NRAS GP1BA RHOA HBB RHOB KIF2A MAPK1 KIF2C KIF2B FCER1G CEACAM3 MAPK3 PTPN1 PTPN11 CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA PPP2CB CD58 ITPK1 CENPE DGKG SRC DOCK5 DGKE ACTN2 DOCK4 DAGLA DGKD DOCK3 DGKB DGKA ABHD6 ABHD12 PLAU PRKCH DGKZ SIRPA DGKQ DAGLB DGKK DGKI DGKH CALM1 DOCK2 DOCK1 VEGFB VEGFC VEGFD THBS1 VEGFA SELL GNA12 CSK JAK2 FGB FGA VWF PLAUR FGG APBB1IP TLN1 VCL CEACAM1 SYK RAD51B LCK FYN F7 APP F9 F13A1 RAD51C POTEKP PROC ISLR F10 LAMP2 PROS1 HABP4 FAM3C CHID1 F2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 KIF28P TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 KIF5C PDGFB A1BG CLU KNG1 KIF21A CYB5R1 KIF21B RASGRP2 KIFAP3 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A PRKACG RARRES2 IGF2 RAF1 IGHV3-23 PRKACA RAB27B PRKACB IGF1 RAPGEF3 PPBP IGLV CYRIB RAPGEF4 IGLV2-8 MANF SELP IGKV1-16 TF KIF16B IGKV1-17 SCCPDH IGKV1-12 KIF20B CALU IGHV3-7 MAGED2 IGHV3-9 HRG IGHV3-30 FERMT3 LGALS3BP IGHV3-33 SERPINA3 KIF3B IGKV1D-39 A2M ORM1 IGKV1D-33 ECM1 SERPINA1 KIF3C WDR1 IGKV2D-28 PLEK IGKV4-1 OLA1 KIF18B IGHV7-81 CTSW KIF4B ORM2 SERPINA4 IGKV2D-30 KIF4A TMSB4X IGHV4-59 ALB IGHV1-69 PHACTR2 KIF12 TIMP3 PHF21A KIF11 QSOX1 PRTN3 TIMP1 IGLV2-11 SRGN IGLV1-40 CAP1 IGLV1-47 TRPC7 KIF15 ABCC4 AHSG KIF19 IGLV6-57 ANXA5 IGLV2-14 F5 IGLV1-44 TRPC6 KIF13B PLCG2 F8 TRPC3 KIF1C IGKV3-15 MMRN1 KIF1B TOR4A IGKV3-11 IGKV2D-40 CD63 IGHV3-11 ITIH4 KIF1A IGHV3-13 ITIH3 PLG IGLV7-43 IGKV1D-16 TTN IGKV1D-12 CLEC3B KIF25 IGLV1-51 CDC37L1 SPP2 IGLV2-23 KIF22 STX4 RCOR1 KIF6 LEFTY2 IGKV3-20 IGHM KIF27 LY6G6F LHFPL2 PCYOX1L IGHV4-34 IGHV1-2 KIF9 CD9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 FLNA IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 HMG20B PPIL2 IGLC1 IGLC2 F2RL2 ADAMTS13 F2RL3 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 F2R IGKC LAT IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 KIF26A IGLC6 IGKV1-5 KIF26B PRKAR1B PRKAR2B PRKAR1A PRKAR2A P2RY12 P2RY1 HDAC1 ACTN1 SIN3A CDK2 ADRA2C ADRA2B F3 ADRA2A SH2B3 AKT1 SERPINE2 GATA4 JMJD1C GP1BB GATA1 F12 HBE1 PRKCD F11 ZFPM2 PRKCA GATA5 GP5 SERPINA5 AK3 YWHAZ GP9 MICAL1 KLKB1 CARMIL1 HBG2 HBG1 EHD1 EHD2 EHD3 MAFF HBD AKAP10 DOCK10 DOK2 AKAP1 SH2B1 CABLES2 GP6 ITGA10 MAPK14 RACGAP1 CAV1 CFD JAM2 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 KIF3A PDE5A DOCK11 EGF PLCG1 DOCK6 DOCK9 DOCK8 DOCK7 PLAT MYB H3-3B F11R H3C8 PRKCZ KIF23 BCAR1 KIF20A ITGB3 ITGA2B GATA2 L1CAM H3C15 ITGAV ITGA5 BRPF3 TNFRSF10B SPARC TNFRSF10A SERPINE1 TNFRSF10D ITGAX KDM1A GNAT3 ITGA2 ITGAL TGFB2 TGFB3 ITGA4 TSPAN7 MGLL HDAC2 PICK1 GNAI3 GNAI1 CBX5 GNAI2 CD36 ALDOA TREM1 MAFK PTPN6 YES1 BSG IGHA1 PTK2 IGHA2 IFNA5 IFNA4 IFNA7 JCHAIN IFNA6 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress JUN CCAR2 DNAJC2 DNAJC7 CXXC1 COX5B RPS19BP1 HSPA4L COX5A HSPA14 RELA HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 COX6C HSPA7 HSPA12A HSPA12B IFNB1 COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM IL6 APOB YWHAE GSK3A CDKN2D EED CDKN2C PDIA6 DNAJB11 CAT IGFBP7 WFS1 SOD2 CARM1 IL1A FBXL17 BACH1 PRKCI TLR4 DNAJC3 SLC7A11 LY96 MED1 OMA1 PRDX2 PRDX1 MAPK7 ADD1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 ATF6 DNAJA4 CRYAB DNAJA2 MAP3K5 CAPZA2 FKBP4 DELE1 HERPUD1 ACTR10 HSPA1B MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 SQSTM1 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 UBE2D2 UBE2D3 HIF3A KEAP1 LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 AR EGLN2 WTIP CDKN2B NPLOC4 NRF1 RPLP0 UBXN7 DPP3 HSPA9 UFD1 TALDO1 SOD1 CAPZA1 CSNK2A1 FKBP14 IGFBP1 GPX1 GOSR2 CSNK2A2 MYDGF EXTL1 TATDN2 LMNA SSR1 CSNK2B DNAJB9 SULT1A3 TSPYL2 ZBTB17 TP53 KLHDC3 DDX11 WIPI1 PGR YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB FKBP5 TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP MAP2K6 PRDX6 NLRP3 ESR1 CLEC1B MDM2 MDM4 GSTP1 NUP205 POM121 HMOX2 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 SMARCD3 NUP133 NUP210 HMGA1 NUP153 NUP93 HDAC6 NUP50 NUP35 RBBP4 NUP54 NUP37 RBBP7 STIP1 TXNRD1 TCIRG1 DYNC1LI1 CAPZB DYNC1LI2 AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 COX7A2L TXN RPS27 ATP6V1B2 EPO TRIB3 ATP6V0D1 CITED2 ATP6V0C ATP6V0D2 VENTX PPP2R5B ATP6V1B1 ATP6V1A SHC1 DYNLL1 ABCG2 DYNLL2 HBB ATP6V1H MAPK1 ATP6V0E2 NFYA ATP6V1G3 NFYB NFYC ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 DYNC1I2 BMAL1 MAPK3 COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A HM13 EIF2AK3 NOX4 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 HSPA6 UBE2D1 HSPE1 ANAPC10 HSPD1 ANAPC11 VEGFA CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN TLN1 RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 SKP1 CCNA2 ATM CCNA1 ATR CUL1 CXCL8 CREB3L3 NUDT2 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 HSPA5 HSBP1 CHD6 GPX3 HSF1 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 DEFA5 BTRC RPS4Y2 RPS27L RPS4Y1 ATOX1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A STOML2 RPS16 GCN1 WDR59 RPS19 PHB2 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT YME1L1 RPS10 DEPDC5 RPS13 KPTN WDR24 RPS12 RPS9 SH3BP4 RPS7 FNIP1 RPS8 FNIP2 RPS5 KICS2 CASTOR1 RPS6 CASTOR2 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 CDKN1A CDKN2A HSP90AB1 SIN3A CDK2 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS PRKAA2 SEC31A EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 RPTOR ATF3 ATF4 TNRC6C CALR MOV10 MLST8 SLC38A9 ID1 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 TXNIP HMOX1 RRAGC MT-CO2 PSMD7 MT-CO3 RHEB RRAGB XPO1 PSMD2 RRAGD KHSRP AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 NUP214 LAMTOR5 DIS3 IDH1 PRKCD NCF1 PSMA5 NCF2 PPARGC1A PSMA6 NCF4 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 ACTR1A DCP2 SERP1 PSMD12 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 CYBB PSMB4 EXOSC5 CYBA PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 CUL7 HSPA8 DCTN2 ADRM1 DCTN3 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PGRMC2 PSMC4 PSMC1 PSMC2 SIRT1 HSPA1A SIRT3 PPARA CYCS HMGA2 H1-1 H1-0 H1-3 CUL3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A TRIM21 HSPH1 HYOU1 HBA2 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 HIGD1A H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 HSP90B1 KDM6B H3C15 RXRA ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 STAT3 H3-4 H2BC1 POT1 NFKB1 TERF2IP H2AC20 RPL4 RPL5 HDAC3 RPL30 RPL3 RPL32 RPL31 RPLP1 NRIP1 RPL34 RPL10L COX4I1 RPL8 COX4I2 RPL10A TBL1X RPL6 RPL7 NCOA1 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 NCOR2 ARNT RPL39 RPL21 RPL23 NCOR1 RPL22 BMI1 TBL1XR1 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RNF2 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 CRTC2 CRTC3 CRTC1 CLOCK MAP2K3 NPAS2 HELZ2 MAP2K4 RAI1 CREBBP MAPKAPK3 SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 TGS1 MEF2D MAP2K7 MAPK10 COX7B FOS GFPT1 FOXO3 COX7C EDEM1 SYVN1 COX8A COX8C AKT3 HIKESHI KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB MECR HADHA ECHS1 ACADM HADH SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs NTRK1 KIDINS220 SOS1 CRK SHC1 NGF MAPKAPK2 NRAS RALA MAPK1 RAP1A MAPK3 BRAF RAPGEF1 MAPKAPK3 MAPK14 MAPK11 YWHAB SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 FRS2 RIT1 MAP2K1 RIT2 CRKL MAP2K2 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection SNRNP200 HDLBP SRSF6 KDELR1 SRSF7 AP2A1 SNRPB AP2A2 SRSF9 DDX5 BAG2 PRPF8 AP2M1 CLU CPSF4 CPSF1 APOA1 HSPA5 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 PRKG2 CD209 RTN3 CHERP ISY1 AP2S1 DDX46 DDX42 YBX1 PTBP1 AP2B1 HAVCR1 BCAS2 P4HB RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 IPO7 PUF60 DNAJB11 U2AF2 P4HA1 P4HA2 SNRPB2 CD14 P4HA3 SMNDC1 DNAJC10 NMT1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 KPNB1 PPIL3 PPIL4 TLR4 DNAJC3 HNRNPA1 STAT2 LY96 RPSA MAPKAP1 PDCD6IP FASN C4BPA C4BPB RPN2 TUSC3 ATG14 RPN1 HSP90AB1 MAGT1 CTNNB1 DNAJA2 C4B_2 OST4 SDC4 ATG7 HSPA1B SDC2 DDOST SDC3 TMEM258 RPTOR DAD1 OSTC CALR CANX ACOT2 MLST8 STT3A STT3B EIF4E GPC1 GPC3 UBE2I GPC2 MRC1 GPC5 SUMO1 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 XPO1 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D XRN1 LYN POLR2E POLR2F POLR2G PABPC1 POLR2H UBA52 POLR2I POLR2J NPLOC4 POLR2K POLR2L H2AC25 NEK2 H2AC21 PDIA3 GTF2F1 CLDN1 GTF2F2 IFIH1 UFD1 UBB UBC RPS27A HSPA8 UBA7 UBA6 UBA5 UBR4 NRBP1 HSPA1A KPNA2 EIF4G1 PEX19 RNASEK ATL2 LY6E KPNA7 NACA KPNA4 HNRNPA0 TIMD4 KPNA5 CD2BP2 KPNA3 HNRNPUL1 TYRO3 BTF3 FURIN AUP1 UBA3 PPIL6 MAPRE3 EMC4 UBA1 ELAVL2 RICTOR H2AC1 CPSF7 SPCS3 SRRM1 SPCS2 VCP CLINT1 SPCS1 SEC11A SEC11C VIM HNRNPC RIPK1 RBMX STING1 NFKBIA SCAP MAVS HYOU1 CLEC5A MAP1LC3B HSP90AA1 KPNA1 H2BC18 MERTK BECN1 DAXX EIF4E3 H2AC19 AXL H2BC26 H2AC14 EIF4G3 EIF4G2 H2BC21 SUN2 TSG101 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 PIK3R1 CDC40 H2AC20 DHX9 HSPG2 CD33 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 CD300A HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 DPM1 SF3A1 DPM2 SF3A2 DPM3 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 RRBP1 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN NCL WBP11 PRPF6 SNRPG SRSF2 PROS1 PPIE NFKBIB SRSF3 F2 SNRPE GAS6 SRSF4 SNRPF SRSF5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases MMP15 COL18A1 MMP17 KLKB1 FURIN CMA1 ELANE CTSG PRSS2 MMP8 MMP9 KLK2 MMP25 MMP1 TIMP2 MMP2 PRSS1 CTRB2 SPOCK3 CTRB1 TIMP1 MMP3 CTSV MMP24 TPSAB1 MMP7 MMP13 CTSK MMP10 PLG MMP11 MMP14 MMP16 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling SOS1 CRK SHC1 FN1 RASGRP2 RASGRP1 RAP1B RAP1A CSK FGB RAPGEF3 FGA RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 AKT1 PTK2 ITGB3 ITGA2B METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY CBS MAT1A NNMT GNMT CTH SCLY HNMT SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport SLC10A6 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C CAMK4 GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL CALM1 CAMK2G ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D GNS CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CYSLTR1 CCL2 EDNRA OPN3 CCL1 RRH EDNRB CCL19 PTGIR PROK2 CCR2 RGR CCL17 AVPR2 PROK1 AVPR1A CCL16 OPN5 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 LPAR4 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 GPR17 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP LPAR6 CMKLR1 NMS PDYN NMU AGTR2 GNRH2 FPR3 GNRH1 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 GPR132 CCKAR GNRHR GPR183 FFAR4 PNOC FFAR3 GPR18 FFAR2 SSTR3 GPR39 EDN1 GPR37 ANXA1 EDN2 GPR35 EDN3 GPR31 CCKBR GPHA2 NPSR1 GRP GPR55 PTAFR NPS GPHB5 PLPPR1 PROKR1 LHCGR PLPPR2 PROKR2 MTNR1A PLPPR3 KISS1R MTNR1B MCHR1 PLPPR4 P2RY10 RLN2 PLPPR5 P2RY11 RLN3 LPAR1 ECE1 LPAR2 GPR4 ECE2 LPAR3 PRLHR LPAR5 MT-RNR2 INSL3 F2RL1 CHRM2 INSL5 S1PR1 PENK F2RL2 CHRM3 S1PR3 F2RL3 CHRM1 S1PR2 APLN GPR37L1 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 KEL PMCH NLN CYSLTR2 PPY MC1R GHSR MC4R OXGR1 F2R GPBAR1 LTB4R2 MC3R UTS2 GAL NTS FSHR MCHR2 NPB OPN4 NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R LTB4R NPY1R APLNR SUCNR1 BDKRB2 HCAR2 BDKRB1 HCAR3 QRFPR GNRHR2 HCAR1 XCL2 XCL1 PYY HTR2B HTR2C HEBP1 ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 ADORA3 ADRA1A CCK ADORA1 HRH1 GPER1 HCRTR2 HTR6 HCRTR1 TAAR3P NPY5R KISS1 HTR7 SSTR1 CGA HRH3 SSTR2 HRH2 HRH4 SSTR4 DRD1 SSTR5 DRD2 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 DRD5 HTR1E CNR2 TAAR8 CNR1 HTR1F TSHR TAAR9 OPRD1 ACKR1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 FSHB ADRA2C C5AR2 HTR5A ADRA2B TAAR1 C5AR1 ADRA2A GPR143 C5 ADRB3 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR ADORA2A AGT TSHB PF4 C3 FPR1 FFAR1 ADRB2 OPN1LW LHB ADORA2B OXER1 OPN1MW RHO NPY CXCR1 CXCR2 OPRM1 SST OPN1SW OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis MUC15 MUC13 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC3 MUC1 ST6GALNAC4 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 MUC12 ST6GAL1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX F9 F10 F8 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria BID CASP8 GZMB NMT1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling RPTOR EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B YWHAB RPS6 MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation KPNA1 H1-1 H1-0 DFFB H1-3 DFFA HMGB2 HMGB1 H1-2 H1-5 H1-4 KPNB1 CASP3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) PCNA POLH MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR FIGNL1 UBA52 FIRRM BLM MRE11 RTEL1 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 RFC5 UBC RMI2 POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE RMI1 POLD2 RFC2 RFC1 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C POLE4 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 POLE2 POLE3 ATR RAD9A RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy MAP1LC3A FUNDC1 ATG5 CSNK2B MAP1LC3B ATG12 ULK1 CSNK2A1 CSNK2A2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH12 RDH8 RBP1 LRAT STRA6 TTR RDH5 RLBP1 RDH11 ABCA4 RDH10 RDH16 SDR9C7 RPE65 RHO MYO7A DHRS9 CYP4V2 RBP3 HSD17B6 HSD17B1 RBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 HSP90AB1 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSBP1 PTGES3 HSF1 HSPA2 CRYAB VCP FKBP4 MAPK3 HSPA1B RPTOR MLST8 CAMK2B HSPB8 CAMK2D HSPH1 CAMK2A MTOR YWHAE NUP205 AKT1S1 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C CAMK2G NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 HSP90AA1 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 NUP37 HSPA9 CREBBP EP300 HSPA8 RPA1 RPA2 EEF1A1 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes NCAPH CSNK2B SMC4 SMC2 CCNB2 CCNB1 NCAPD2 CSNK2A1 CDK1 NCAPG CSNK2A2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G IQGAP1 FAM114A2 QKI KIAA1549 ESRP1 TRIM24 FXR1 FN1 AGTRAP ARAF AP3B1 PEBP1 CSK AGGF1 JAK2 TENT4A MARK3 FGB FGA VWF KSR1 FGG BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation NR1H2 CLTC PCSK9 NR1H3 UBC AP2S1 CLTA AP2A1 VLDLR RPS27A AP2A2 AP2B1 UBA52 AP2M1 MYLIP UBB DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME UGT2B7 SLCO1B1 SLCO1B3 GSTA1 ABCC2 XDH GGT5 GGT7 GGT6 CNDP2 GGT3P GGT1 SLC16A1 ALB ACY1 SLC22A3 GSTP1 ABCC4 CES1 SLC22A2 SLC22A1 CYP2C9 CYP2C8 CYP2C19 MAPDA ADK AKR1C1 PNP CYP2D6 HPRT1 SLC22A7 IMPDH1 ADA IMPDH2 SULT2A1 CES2 SLC28A2 RAC1 SLC29A1 VAV3 SLC29A3 SLC29A2 SLC28A3 VAV1 VAV2 CYP2E1 HSD11B1 ABCG2 HSD11B2 GMPS TPMT GSTT1 UGT1A3 PCK1 GSTM1 NME2 SERPINA6 SULT1A1 SULT1E1 ACSM2B SULT1A4 ABCC3 ABCC1 SULT1C4 BCHE PON3 PON1 NME1 NAT1 NAT2 SLCO1A2 ABCC5 NT5C2 ABCB1 NUDT15 ADH1A GSTA2 UGT1A10 ITPA UGT2B28 UGT1A5 UGT1A4 UGT3A2 SLC22A8 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 BSG GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A CYP3A4 ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 GUK1 UGT2B4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi MAN1C1 MAN1A2 MGAT1 MAN1A1 MANEA RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCA NCF2 NCF4 RAC2 PIK3R4 NOXA1 NOXO1 NOX3 MAPK14 PRKCZ MAPK11 NOX1 PRKCB MAPK1 RAC1 S100A9 PIN1 S100A8 CYBB CYBA MAPK3 PIK3C3 PRKCD NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 RPS27A FGF4 CBL FGF9 UBA52 FGF20 MKNK1 SPRY2 MAPK1 FGF23 FRS2 MAPK3 BRAF PTPN11 UBB FGF16 PPP2R1A KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway MAFG RELA PGD NQO1 GSTA3 MUL1 GSTA1 SESN1 SRXN1 CHD6 CUL3 VCP CCL2 ABCF2 SOD3 G6PD GCLC GCLM TRIM21 SESN2 MAP1LC3B EGF BTRC SKP2 FBXL17 BACH1 PRKCI TXNRD1 SLC7A11 EP300 AKT2 TXN NOTCH1 PRDX1 NFKB1 CDKN1A ABCG2 CDKN2A PRKAA2 SQSTM1 ATF4 TKT ABCC3 MYC ABCC1 PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 EIF2AK3 AMER1 GSK3B IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 NPLOC4 PSMD11 ME1 PSMD14 UBXN7 PSMD13 PSMA7 BRCA1 PSMB6 PSMB7 PSMB4 DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 BCL2 PSMB1 PDGFA MAFK RPS27A AREG NFE2L2 BCL2L1 ADRM1 CSNK2A1 PALB2 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 CUL1 AKT3 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CREBBP PER3 CRY2 CRY1 BMAL1 CSNK1D KMT2A CSNK1E CLOCK NPAS2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency GSS RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle TFRC VANGL1 WDR11 SLC4A7 UACA RHOH TMEM59 JUP TUBA1B ROCK1 ARHGDIB ROCK2 CSK RALGAPA1 FAM91A1 VCP NSFL1C DBN1 VAMP3 RAB7A SLC1A5 NIPSNAP2 PAK6 ARHGDIG STOM PAK1 PAK5 LCK MTR ARHGDIA PAK2 ZAP70 LAMTOR1 PAK4 OSBPL11 DBT CAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A PACS1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLCO4A1 SLC26A2 SLC22A5 SLC17A1 SLC24A2 SLC24A3 SLCO2B1 SLC41A2 SLC5A1 SLC26A11 SLC41A1 SLC5A2 SLC30A10 SLC16A2 SLC39A6 SLCO1B1 SLC39A5 SLC26A1 SLCO1B3 SLC39A8 SLC15A1 SLC39A7 SLC14A1 CTNS CP SLC39A2 SLC15A3 SLC14A2 SLC6A5 SLC39A1 SLC15A4 SLC4A10 SLC39A3 SLC2A9 SLC30A8 SLC26A4 SLC30A3 SLC26A7 SLC30A2 SLC26A3 SLC31A1 SLC26A9 SLC30A5 SLC26A6 SLC40A1 SLC39A10 SLC25A1 SLC2A1 SLC30A1 SLC2A2 SLC6A2 SLC39A14 SLC13A1 SLC6A3 SLC8B1 SLC8A1 SLC13A2 SLC22A12 SLC8A2 SLC13A3 HEPH SLC13A4 SLCO1C1 SLC2A10 SLC47A2 SLC47A1 SLC5A12 SLC5A10 SLC25A26 SLC24A4 SLC16A7 SLC16A8 EMB SLC11A1 SLC16A3 SLC13A5 FGF21 RSC1A1 AHCYL2 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 SLC24A5 SLC22A4 SLC22A3 SLC22A6 SLC45A3 SLC10A6 SLC22A15 SLC22A16 SLC22A11 SLC20A1 SLC8A3 SLC2A6 SLC2A7 SLC2A8 PDZD11 SLC50A1 SLC4A8 SLC4A9 SLC6A20 SLC35B3 SLC43A2 LCN9 SLC1A1 SLC35B2 SLC43A1 SLC27A1 SLC1A2 SLC35B4 SLC3A1 SLC35D1 SLC1A3 SLC35D2 SLC1A4 LCN15 SLC3A2 LCN12 SLC7A11 SLC7A10 SLC35A2 SLC1A6 SLC35A3 SLC33A1 SLC1A7 SLC5A6 SLC7A1 ARL2BP SLC7A3 LCN1 SLC25A29 SLC29A4 SLC38A3 SLC27A6 SLC38A2 SLC28A2 SLC36A4 SLC29A1 SLC38A5 SLC2A13 SLC28A1 SLC38A4 SLC29A3 SLC36A1 SLC5A11 SLC6A19 SLC5A3 SLC29A2 SLC28A3 SLC38A1 SLC27A4 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC5A5 SLC32A1 SLC6A13 SLC20A2 SLC6A1 SLC6A9 SLC17A6 SLCO1A2 SLC1A5 ARL2 SLC67A1 SLCO4C1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 SLC22A7 SLC12A2 RUNX1 SLC12A4 SLC6A7 SLC12A5 SLC12A7 SLC6A11 SLC25A18 SLC25A11 SLC6A4 APOD SLC17A7 SLC25A22 SLC2A3 CALM1 SLC35C1 SLC4A7 SLC25A10 SLC24A1 SLC17A5 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 AVP SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC2A4 SLC35A1 SLC22A8 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 BSG SLC5A9 SLC12A6 SLC60A2 SLC39A4 SLC34A3 SLC5A4 SLC34A2 SLC2A14 SLC34A1 SLC2A11 SLC11A2 SLC2A12 SLC5A7 SLCO2A1 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 CDK2 MLH1 FIGNL1 TEX15 MSH4 MSH5 MND1 FIRRM BLM MRE11 BRCA1 BRCA2 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 H2AC19 H2BC26 H2AC14 SPO11 H2BC12L H2BC21 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 H2BC11 ATM H3C15 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation JUN IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 HRAS VAV3 VAV1 VAV2 SOS1 V2-11 V3-4 NRAS V3-3 V2-17 IGHE V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 MAPK8 MAPK3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN MAP2K4 MAPK9 SYK PAK1 MAP2K7 MAP3K1 MAPK10 FOS PAK2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 HES5 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 TACC3 MAMLD1 PSEN1 RBPJ SMAD3 ACTA2 SNW1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 FLT4 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A HEY1 KAT2B KAT2A EP300 HEY2 JAG1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 MAML3 NOTCH2 NOTCH1 CUL1 NOTCH4 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EED UXT PCGF6 RRM2 EPC1 CDC7 E2F1 RBBP4 EZH2 BRCA1 RYBP RBBP7 TFDP1 TFDP2 CHEK1 RBBP8 YAF2 EHMT2 EHMT1 MAX BMI1 CBX3 RING1 L3MBTL2 RNF2 E2F6 SUZ12 RAD51 PHC1 CBX5 MGA PCGF2 PHC3 APAF1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 GLRX5 FDX1 FXN SLC25A28 FDX2 SLC25A37 LYRM4 FDXR HSCB RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport CYCS MT-ND6 COX5B COX5A MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 COX6C TMEM126A UQCRC2 TMEM126B TRAP1 SURF1 COX6A1 COX6A2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 COX6B2 NDUFAF2 SFXN4 COX6B1 NDUFAF3 NDUFAF1 HIGD1C HCCS TMEM186 RAB5IF OXA1L ACAD9 COQ10B COQ10A TMEM177 DMAC1 DMAC2 UQCR11 UQCR10 PET117 TIMMDC1 PET100 MDH1 MDH2 NUBPL LETM1 LYRM2 LYRM4 LYRM7 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 NDUFAB1 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 COX18 HIGD1A UQCRH COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 UQCRFS1 COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 MT-CO1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 BCS1L COXFA4 NDUFA6 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 COX19 TTC19 COX17 UQCRHL SCO2 MT-CO2 MT-CO3 CYC1 NDUFS3 GOT2 HSCB ECSIT HSPA9 TIMM21 SLC25A12 FXN SLC25A13 NDUFB8 COX7B COX7C COX8A COX8C FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm TBX6 BMP4 LEF1 MAMLD1 CTNNB1 MESP2 DLL3 HES7 MSGN1 RBPJ RIPPLY2 SNW1 EPHA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 NOG PSMD11 PSMD14 PSMD13 WNT3A PSMA7 PSMB6 FGFR1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP MAML2 PSMB1 MAML1 KAT2B KAT2A LFNG EP300 ADRM1 TBXT PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 MAML3 NOTCH1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 SEL1L MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 CP MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 RNF185 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 DERL1 MRPL45 DERL2 MRPS6 RNF5 MRPL46 MRPS5 OS9 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 ARF4 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 EXOC8 EXOC7 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 EXOC4 MRPL12 EXOC3 MRPL57 EXOC6 MRPL13 EXOC5 MRPL54 EXOC2 MRPL10 EXOC1 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 GBF1 MRPL21 MRPL22 KGD4 RAB11A MRPL30 MTRES1 MTRFR NDUFAB1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN PIAS3 DDB1 UBE2V2 COPS7B XPC COPS7A CUL4A COPS3 COPS6 COPS5 UBE2N COPS8 BDH1 OXCT1 HMGCS2 ACAT1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 CAPZA3 CAPZA2 ACTR10 SQSTM1 TFAP2B TFAP2C TWNK UBE2I SUMO1 SSBP1 EIF1AX EIF4H UBE2D2 EIF3M UBE2D3 EIF3K HIF3A EIF3L EIF3I ELOB EIF3J ELOC EIF3G RBX1 EIF3H EIF3E EPAS1 EIF3F CUL2 EIF3C HIF1A EIF3D VHL EIF3A EIF3B GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 EIF5A FBXL5 DHPS WRAP53 FN3KRP TUBA8 GNGT1 EIF5A2 TUBA1C FN3K ICMT TUBA1B GNGT2 DOHH TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 KLK13 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 NUP37 CDC20 MT-ND4L PARS2 MRTFA EARS2 LARS2 PPA2 DYNC1LI1 PPA1 TARS2 DYNC1LI2 TARS1 AARS1 AARS2 HARS1 HARS2 CDCA8 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 TCF25 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 DYNLL1 CARS2 VARS2 RANGAP1 ANKZF1 KLHDC10 DYNLL2 TSFM EIF5B RHOA MARS2 DARS2 INCENP EEF1G BIRC5 SARS2 NEMF EEF1D MTRF1L EEF1A1P5 MTIF2 PRMT3 MTIF3 DYNC1I2 IARS2 WARS1 WARS2 AURKB DYNC1I1 DYNC1H1 TFG GOLGB1 GLUD1 NFKB2 ANK1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ACE2 LAMB2 FN1 LAMB1 LAMC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 RPS20 LRR1 CCNF FAU RPS21 UBE2L6 RPS24 B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B ASCC2 ASCC3 CDC34 SFTPA2 PSME1 FSHB INHBB UBE2J2 INHBA INHA INHBC INHBE SEC31A SIAH1 FBXL8 EIF4EBP1 CALR FBXL4 EIF4E EIF4B LRRC41 GAN RRAGA KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 CUL7 CUL5 UBA6 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H YKT6 KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 SEC61A2 SEC61A1 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 GALNT1 CALCA ARFGAP3 ARFGAP2 IAPP MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 TPST2 SEC16A KTN1 TPST1 TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RPL4 RPL5 RPL30 RAD52 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A MATN3 RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 CHD3 RPL23 BMI1 RPL22 RPL13A SUMO3 RPL9P9 SUMO2 RING1 RPL37A PIAS1 RPL24 HDAC4 RPL27 HDAC2 RPL26 L3MBTL2 RPL29 SATB1 RPL28 SATB2 RPL10 RNF2 RPL12 ZBED1 RPL11 RPL36A SUZ12 CBX8 RPL14 PHC2 RPL13 PHC1 RPL15 CBX5 RPL18 CBX4 RPL17 PCGF2 RPL19 CBX2 RPL39L PHC3 RPL41 AMER1 RPL35A RPL23A RPL3L AXIN1 RPL27A RPL22L1 APC ABCE1 RPL26L1 CDC73 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 RWDD3 UBA2 SAE1 CREBBP AREG NFE2L2 SAA1 TGFA EIF2AK2 MGAT3 APEH HEMK2 ETF1 GSPT2 GSPT1 APOB MME CES1 USO1 TUBB8 RAB2A TUBB8B EIF2B5 EIF2B4 EIF2B3 EIF2B2 RAB1A EIF2B1 RAB1B HGS RAB5A TOP2A GORASP1 STARD7 FDX1 OMA1 OPA1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 FUT8 MITF GANAB MAN2A1 MGAT5 MGAT1 MGAT2 OST4 EDEM2 MOGS ARF3 ACHE DDOST MGAT4C HTRA2 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 LONP1 TRRAP CCP110 BCHE KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 AGT USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PIAS4 VDAC1 CFTR GATA3 BRCC3 SNX3 RHOT1 RCE1 ZRANB1 SIAH2 INO80 STAM TADA2B CYLD H2AC25 H2AC21 BAP1 WDR48 OTUD7A OTUD7B RAB4A BABAM1 IFIH1 BABAM2 UCHL1 TRIM4 UIMC1 UFD1 IKBKG TOMM70 RIPK2 ACTL6A JOSD2 UCHL3 JOSD1 ALAS1 UCHL5 DDB2 KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 USP17L21 USP17L20 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 SFTPC USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 ECI1 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 CLSPN SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 STAR USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 USP25 USP26 USP20 USP21 RAB32 USP22 RAB35 TAF10 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 HADH RAB39B RAB8B RAB33A RAB7B RAB21 CHML RAB11B RAB12 RAB13 ARG2 ALPI HNRNPK PIGS PIGU PGAP1 PIGT GPAA1 PIGK OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 CDH2 METTL21A KIN MYO5A METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT MYRIP EEF1AKMT2 EEF1AKMT1 DDX5 FFAR4 GRP U2AF2 GALNT11 GALNT14 GCG GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNTL6 P2RY2 ADRA2C COL7A1 ADRA2A MDC1 MT-CO1 B4GALT1 DTL MT-CO2 MT-CO3 GATA4 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 FOXL2 HIC1 SP3 ALDH2 PPARG PPARA LY6E MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 BGLAP SPP1 SUCLG2 UQCRC2 OGDH MT-ATP6 RORA FH DLST ATP5PF ATP5PD MDH2 ATP5F1C MT-ATP8 ATP5PO NDUFA13 SOCS3 NDUFV3 ATP5MG NDUFV1 IDH2 UQCRQ MT-CYB ETFB ME2 IDH3A FBXO32 SFTPB SFTA3 SFTPA1 NDUFS1 NDUFB6 COX4I1 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 RABGGTB ADGRF5 RABGGTA NDUFA2 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 EEF2 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NR5A1 PCNA COX5B COX5A RELA NPM1 NR3C1 NPPA KLK3 SP100 KLK2 RAB9A RAB9B KIF5B KIF5A VDR IL6 PCSK2 ERO1B CPA3 CDX2 LEP ENPEP CPB1 SENP5 CLTRN SENP2 NOP58 TRIAP1 ACE CPE REN CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 IGFBP2 SHISA5 PDIA6 PAPPA MXRA8 SPARCL1 IGFALS AURKA SCG2 KLK1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A ZNF131 FUCA2 UHRF2 DDX17 HRC CASP8AP2 MELTF MBD1 SERPINA10 SAFB MIA3 MSLN TOPORS PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 B4GALNT2 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 TOP2B TOP1 SERPIND1 GOLM1 POFUT2 GZMH NUCB1 NOTUM POFUT4 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 PRELID1 LYPD8 LYPD6B PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CPB2 LRRC49 PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 CHM TTLL1 TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H ING2 SPRN SPACA4 NICN1 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 RAB22A CD59 CD52 CD55 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 RAB40A ZNF350 RAB40B RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 RAB29 RAB15 RAB19 RAB17 TTLL10 NFU1 TTLL13 MEN1 TTLL11 TTLL12 IGFBP1 UMOD LIAS OTOA RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FUCA1 WDR5 RAB3D RAB44 RAB31 RAB37 RAB5B RAB5C HDAC7 RAB6A TRAPPC1 RBBP5 RAB4B RBBP7 FCGR3B KLF4 PML MSRA PCMT1 MSRB2 MSRB3 MSRB1 TTR RAB24 RAB10 TSPAN14 RAB18 ANPEP TXN COMMD9 PARP1 BST1 VNN1 CTSZ CTSH CTSC COMMD3 KCTD6 NR4A2 SRP14 THRB CGB8 COPB1 NR2C1 THBS1 HSPD1 ADA2 POMC ATP6AP2 FGA PLAUR FGG CAND1 F7 F9 PROC F10 GGCX PROS1 PROZ F2 GAS6 DBT DLD PCSK9 APOA2 APOA1 APOA4 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB BTRC ADAMTS13 MTA1 HSD17B10 EPRS1 TRMT112 SOCS2 SOCS6 IKBKE CETN2 ACTR1A CSNK1D DCTN2 DCTN3 JMJD6 RIOX2 ANO8 RNF168 ANKRD28 ASPH PPP6C PPP6R3 TP53BP1 COP1 SMC1A SMC3 STAG1 STAG2 RAD21 TDG DCAF13 PRL CALB1 NAT8B BACE1 APCS TSPAN33 GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI ITM2B CSF2RB CSF2RA NCOA2 PNPLA2 TTF1 CTBP1 DNMT1 DNMT3B DNMT3A SLC30A8 SLC30A5 STS ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD SFTPD TUFM UBE2L3 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MARS1 DARS1 SARS1 EEF1E1 GSN KARS1 IARS1 UBE2T OTULIN ALDH1B1 APH1A PSENEN NCSTN APH1B ADAM10 FBXL18 FBXL7 SDC2 TMED2 GPC3 ADORA2A UCN MBOAT4 PLA2G7 CRHR2 GH1 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 TSHB DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF1 NPLOC4 DDA1 RPLP0 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CISH CUL9 DPP3 HSPA9 UBD NAE1 SOCS5 WDTC1 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B CAPZA1 NEURL2 ERCC8 PSME2 GOSR2 SSR1 ARFGAP1 SRPRA SRPRB PREB KDELR3 PCCB PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 RWDD1 SEC11A JMJD4 KDM8 SEC11C JMJD7 RIOX1 OGFOD1 DRG1 DRG2 RCCD1 ZC3H15 ADORA2B SHMT2 STX5 CMA1 IDE CAPZB GATA6 CTSD TFAM SCFD1 SPTBN1 PARK7 MUC13 INS FGF23 ABCA3 GRIA1 CKAP4 SENP1 CALM1 NDUFS3 UBE2C UBE2E1 UBE2D1 PDHB UBE2S CDK1 DLAT BLM PDK1 BRCA1 PDHA1 WRN BARD1 FBXW11 RPA1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 RAB41 KIF5C KNG1 COG8 COG7 COG6 COG5 IGF2 COG4 RAB27B COG3 CTSG IGF1 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG LTF MAN1A2 F5 TMED3 F8 MMRN1 MAN1A1 TMED7 PLG TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B ARF5 NAPA NAPB GOSR1 NAPG GOLGA2 LYZ BPIFB2 MAN1C1 SEMG1 SPG7 GALNT2 AFG3L2 ARCN1 SMDT1 YME1L1 PMPCA MICU2 COPG2 COPG1 LTBP1 TCF7L2 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A CHCHD2 CTNNB1 EIF2S2 EIF2S1 EIF2S3 ECH1 SPTB ACOT2 STX1A MYC LDHD ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 SPTBN5 PSMD2 PSMD3 SPTBN2 PSMD1 NUP214 CS PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ACO2 PABPC1 UBA52 PSMD12 SEC61G PSMD11 TIMM17A PSMD14 SEC61B PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 TIMM22 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 PSMC5 PSMC6 TIMM9 PSMC3 PSMC4 PSMC1 PSMC2 TIMM10 EIF4G1 ATP5F1A ATP5F1B PEX10 PEX12 SRD5A3 C3 PEX13 PEX14 FURIN IL33 RNF20 CCT2 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC CCT7 B2M HLA-A VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT CCNE2 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 H2BC11 RARA H3C15 RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 HDAC3 KDM1B GNAT3 NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 FBXL21P ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 SLC34A2 MRPS17 SLC34A1 MRPS15 MRPS16 MRPS14 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR BTRC JAK2 SKP1 RBX1 CUL1 PTPN11 GH1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 ALOX15B PTGS2 ALOX15 GPX2 GPX1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix MMP15 COL18A1 MMP17 MMP19 TMPRSS6 NID1 FURIN CAPN8 SPP1 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 CTSG HTRA1 SCUBE3 PRSS2 SCUBE1 BMP1 KLK2 MMP25 A2M TIMP2 ADAM17 SPOCK3 CAPN13 TIMP1 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 DCN TLL1 BCAN PLG LAMA5 LAMB3 CMA1 ELANE LAMA3 ADAM8 LAMB1 LAMC2 LAMC1 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST MMP1 MMP2 CTSD MMP3 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 NCSTN COL23A1 HSPG2 ADAM10 PSEN1 ACAN COL9A1 CD44 COL9A3 COL9A2 CDH1 CTSS ADAMTS4 ADAMTS5 ADAMTS1 ADAMTS8 ADAMTS9 KLKB1 ADAMTS16 ADAMTS18 MMP8 MMP9 PRSS1 PHYKPL CTRB2 CTRB1 OPTC KLK7 CTSB BSG CTSV MMP20 MMP24 CTSL TPSAB1 MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 CASP3 MMP16 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT5A STAT5B STAT3 IL22 JAK3 STAT4 JAK2 IL20RA IL20RB IL22RA2 JAK1 STAT1 IL22RA1 IL10RB PTPN11 TYK2 IFNLR1 IL20 STAT2 IL26 IL24 IL19 IFNL2 IFNL1 IFNL3 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers JUN ADCY9 NTRK3 NTF3 ADCY4 ADCY3 PDGFB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 IRAK1 ITPR2 ITPR3 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PRKAR1B PRKAR2B PDGFRA PRKAR1A RAC1 PRKAR2A PRKX KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PRKCD PRKCA PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 AHCYL1 PSMC4 PDE1C PSMC1 CSNK2B CAMKK1 PSMC2 CAMKK2 GRK2 KPNA2 PRKCG TP53 PRKCE NBEA CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 PLCG1 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 CAMK2B ESR2 CAMK2D HDAC2 SRC NR4A1 CAMK2A NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 CALM1 GSK3B CAMK2G IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK CAMK4 FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 TGIF2 EED POMT2 POMT1 PRKCI RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures MUS81 FIRRM BLM SLX4 RTEL1 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 PGM1 GALM DHDDS DPM1 NUS1 DPM2 DPM3 GALK1 MPI GALE PMM2 GFPT1 DOLK GNE GALT POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events PRKCA GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 ADRA2C RGS4 ADRA2B RGSL1 ADRA2A GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCB GNAI3 RGS20 PRKCH RGS17 GNAI1 RGS19 PRKCG PRKCQ GNAI2 PRKCE RGS16 GNG10 GNG12 PRKCD GNG11 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G2D PLA2G2E PLA2G3 PLA2G5 PLA2R1 PLA2G10 LPGAT1 PLA2G4F PLA2G12A PLA2G4D PLA2G4B PLA2G2A PLA2G1B LPCAT4 CRLS1 PLA2G2F LPCAT1 PLA2G4A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse PLXNB1 ERBB2 RHOC SEMA4D RHOA LIMK2 RHOB LIMK1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MYH10 MYL9 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 PTEN EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 AKT2 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 TRIB3 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A THEM4 PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PHLPP2 PIP5K1C PHLPP1 CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN AKT3 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism ALDOB GLYCTK SORD KHK ALDH1A1 TKFC AKR1B1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria ASL KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF28P KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIF5C KIF21A KIF21B KLC1 KIFAP3 KLC4 KIF2A KLC3 KLC2 KIF2C KIF2B KIF16B KIF3A KIF20B KIF3B KIF3C KIF5B KIF5A KIF18B KIF26A KIF4B KIF26B KIF4A KIF12 CENPE KIF11 KIF23 RACGAP1 KIF15 KIF19 KIF13B KIF1C KIF1B KIF18A KIF20A KIF1A KIF25 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes CREBBP PRDX1 ATF4 MAFK SLC7A11 GCLC NFE2L2 EP300 GCLM NQO1 GSTA3 GSTA1 SRXN1 CHD6 HMOX1 TXN SOD3 BACH1 TXNRD1 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease SOS1 CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 NRAS TRIM24 PLCG1 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 HRAS ZMYM2 GAB1 FGFR1OP2 FRS2 GAB2 PIK3CA SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC PHOSPHO1 CHPT1 ABHD3 PCYT1B PCYT1A CHAT CHKB CHKA STARD10 MFSD2A ACHE LPCAT1 PCTP LPIN1 LPIN2 LPIN3 CSNK2A1 CSNK2A2 CEPT1 BCHE CSNK2B STARD7 PEMT SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PLCG1 FGF20 FGF23 FGF22 FGF16 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency CPS1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CHTOP ALYREF DDX39B SRRM1 DHX38 NXF2B NXT1 UPF3B MAGOHB RNPS1 NUP205 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency BTD LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs RHOC PPP1R12A RHOA LIMK2 RHOB PAK1 LIMK1 ROCK1 MYL12B ROCK2 MYL6 MYH9 CFL1 MYH14 MYH11 MYH10 MYL9 PPP1R12B PPP1CB DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) UBC TICAM2 TICAM1 RPS27A TBK1 IRF3 TRAF3 OPTN LY96 UBA52 CD14 IKBKE IRF7 TANK PTPN11 UBB TLR4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription HES1 HDAC5 CCNC HDAC1 UBA52 HES5 TLE4 HDAC3 HDAC8 TLE2 HDAC9 TLE1 HDAC6 HDAC7 HEYL MAMLD1 TBL1X UBB RBPJ CREBBP UBC CDK8 MAML2 NCOR2 MAML1 RPS27A HEY1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 EP300 SNW1 HDAC11 MYC HEY2 HDAC4 HDAC2 SKP1 RBX1 MAML3 NBEA HIF1A NOTCH1 CUL1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines NSD2 KMT5C SUV39H1 MECOM H4C9 RELA EED SMYD3 NFKB1 ATF7IP SETD1B SETD1A AEBP2 RBBP4 NFKB2 EZH2 RBBP5 PRDM16 RBBP7 KMT2D PRDM9 EHMT2 EHMT1 ASH2L KMT2C KMT2B SETDB2 SUV39H2 SETD2 SETD3 SETD6 SETD7 H3C8 ASH1L DOT1L SMYD2 NSD3 SUZ12 NSD1 DPY30 SETDB1 WDR5 KMT2A KMT5A H3C15 KMT5B METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway GOT1 MRI1 MTAP APIP ENOPH1 ADI1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes JUN PMS2 MLH1 CDK12 CDK13 FANCI MDC1 ATF2 FANCC FANCD2 CCNT2 ELOB ELOC CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L MSH2 GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 BRCA1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 CHEK1 NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 DDB2 CDK9 TCEA1 RAD51D FOS TP53 ATM ATR FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation SERPINA5 CD177 THBD F13B PRTN3 SERPINC1 F13A1 PROC F10 SERPIND1 F5 FGB PROS1 F8 PF4V1 FGA F2 SERPINE2 FGG PF4 F2R PROCR RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB8B RAB43 RAB14 RAB41 RAB33A RAB7B RAB21 RAB27B CHML RAB11B RAB12 RAB30 RAB13 RAB36 CHM RABGGTB RABGGTA RAB9A RAB6B RAB9B RAB39A RAB22A RAB3D RAB40A RAB40B RAB44 RAB40C RAB3A RAB33B RAB31 RAB2A RAB37 RAB5B RAB5C RAB3B RAB3C RAB42 RAB11A RAB6A RAB1A RAB2B RAB1B RAB4A RAB4B RAB34 RAB5A PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB7A RAB29 RAB32 RAB15 RAB35 RAB19 RAB17 RAB27A RAB38 RAB24 RAB8A RAB10 RAB18 RAB39B 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4F3 CYP4A22 CYP4B1 CYP2U1 CYP2S1 CYP4F2 CYP2W1 CYP2D6 CYP4A11 CYP3A43 CYP4F22 CYP4F11 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle ARHGEF9 ARHGAP26 OBSCN MPP7 VANGL1 ARHGAP32 ARHGEF7 ARL13B RHOQ TRIP10 CDC42 CPNE8 STEAP3 GJA1 FNBP1 SCRIB GFOD1 LAMTOR1 IQGAP1 TFRC IQGAP3 SNAP23 CFTR ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 GOPC SYDE1 ARHGAP33 OPHN1 GIT1 WASL PLEKHG3 DEPDC1B CDC42EP1 VAMP3 RAB7A CDC42EP4 CDC42EP3 CDC42EP2 ITSN1 ARHGAP17 SLC1A5 ARHGAP21 PREX1 STOM PAK1 CDC42BPB SRGAP2 CDC42BPA PAK2 DLC1 PAK4 DIAPH3 GIT2 CAV1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol TRIT1 ADAT2 TRMT6 TYW5 TRMT61A TYW3 TRMT5 TYW2 TYW1 LCMT2 ALKBH8 THG1L TRMT44 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B EPRS1 TRMT13 TRMT11 QNG1 TP53RK WDR4 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 URM1 LAGE3 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress CXCL8 DCP2 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EXOSC4 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP DIS3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome HBEGF PXN AREG EGF PIK3R1 EGFR SRC CSK TGFA GAB1 EREG PIK3CA BTC PTPN11 EPGN PAG1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 RBX1 NOTCH1 CUL1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A3 SLC22A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints PLK3 CDKN1A CDKN2A CDC25A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 CHEK1 PSMB5 CSNK1E CCNE1 NEK11 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 TP53 CCNA1 ATM CUL1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB ACADL HADHA SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAP2K1 MAP2K2 MAPK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN DOCK3 RAC1 GRIN2B NTRK2 BDNF SRC MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN PRP4K ZCRB1 WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina PRKCB PRKCA EMD LMNB1 LPIN1 CCNB1 LPIN2 LPIN3 CNEP1R1 CDK1 LEMD3 LEMD2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response OAS1 OAS3 ABCE1 RIGI RNASEL FLNA OAS2 PDE12 OASL PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane TMEM258 DAD1 OSTC STT3A STT3B RPN2 TUSC3 PDCD1LG2 B3GNT3 RPN1 PDCD1 MAGT1 MIB2 OST4 JAK1 CD274 DDOST RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 CDC42 KLC4 RAC1 KLC3 KLC2 KTN1 KIF5B RHOG KIF5A RHOA KLC1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins LY6E CD109 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 BST1 LYPD6B PIGO VNN1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH ALPI LY6K GPIHBP1 LY6D LY6H SPRN SPACA4 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 CD52 PRND CNTN5 CEACAM5 ALPL CNTN3 CNTN4 ALPG TEX101 GPLD1 GP2 PRSS21 PRSS41 DPM1 DPM2 DPM3 TECTA TECTB VNN2 PIGS PIGU PGAP1 PIGT GPAA1 PLET1 CPM PLAUR PIGK PSCA MELTF RTN4RL2 MSLN FCGR3B RTN4RL1 OTOA RAET1G RAET1L IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM FOLR2 ULBP2 OPCML NEGR1 XPNPEP2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 MYO6 AP2M1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation CYB5B NOSTRIN HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NOSIP WASL DNM2 NMT2 AKT1 ZDHHC21 CALM1 CAV1