ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA