HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA