HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 FGF20 THEM4 ATP6V1H MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 MAPK3 PTPN1 INSR PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 KLB FLT3 IRS1 PDE3B IRS2 PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 PTPRF FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 TRIB3 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 ABCA3 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2C GRIN2B NRGN GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer MAPK1 PIK3CB PIK3R2 PIK3R1 PIK3CA MAPK3 CLIP1 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC25A15 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 DEFB4B S100A8 LTF TLR2 S100A7 DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation PLK1 TCF7L2 CCNB1 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B TBX2 HINT1 CCND1 SIN3A CDK2 CTNNB1 MET RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 ATF5 ATF3 ATF4 GRB10 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements YWHAB HSPB1 ELAVL1 PSMD8 PSMD6 ZFP36 PSMD7 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 CCNB2 NEK9 CCNB1 NEK6 NEK7 CDK1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle HNRNPC CCT7 RBMX DBN1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA UBC ZBP1 TREX1 RPS27A DDX41 DTX4 TBK1 IRF3 STING1 NLRP4 UBA52 TRIM32 TRIM21 TRIM56 UBB CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG4 GUSB ARSB IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 CDKN1A DEK FLI1 KLF5 H2AC20 LEF1 CDK2 CEBPB MYC E2F1 TFDP1 TFDP2 CDK4 H2AX CSF3R SPI1 GFI1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TAL1 H2BC11 RARA CEBPA KMT2A CBFB CEBPE GATA2 H3C15 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling RXRA SCD FASN CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 FABP6 EP300 APOC2 APOC1 AGO1 ANGPTL3 AGO2 PLIN1 TNRC6A ABCG1 TNRC6B BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SRD5A3 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage XIAP CYCS CASP9 CASP7 APAF1 CASP3 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 CCNE1 STAT3 HDAC3 GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 RAC1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 ACTB CLIP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS GLUD1 GLUD2 KYAT1 RIMKLA GLUL RIMKLB PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 PLCG1 FGF20 FGF16 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development DLL1 POU3F3 WNT4 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling NTRK3 NTF3 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 YWHAB RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB RAPGEF3 SIPA1 RAPGEF4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide CA4 CA7 CA6 CA9 CA14 CA13 CA12 CA1 CA3 CA5B CA2 CA5A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 DICER1 TARBP2 TSN AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HBEGF EGFR HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia ARG1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CCT6A HSP90AA1 CDC37 HSP90AB1 RNF20 TWF1 SPEN MSI2 CCT2 RHOBTB2 CPSF7 ROCK1 ACTN1 ROCK2 TMOD3 GPS1 DDX39B CUL3 PHIP TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 ACTG1 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS1 GINS2 CDC45 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA AKT2 STRADB TSC2 TSC1 PRKAB1 YWHAB RPS6 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 AKT1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle TIAM1 ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 PIK3R2 NOXA1 PIK3R1 ABI1 NOX3 ESYT1 FERMT2 NOX1 ABR MCF2 CDC42 LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SRGAP2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 DIAPH3 ITGB1 GIT2 VAV2 CAV1 MCAM LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR2 TGFB1 TGFBR1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 HMGA1 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 TP53 H1-5 H1-4 HIRA UBN1 EP400 ASF1A INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway IL36B IL36G IL36RN IL1F10 IL1RL2 IL36A DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions DSCAM DCC DSCAML1 NTN1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle ARHGAP26 BAIAP2 VANGL1 ARHGAP32 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 DAAM1 CDC42EP3 TRIO CDC42EP2 RASGRF2 WAS ITSN1 PARD6A PLEKHG4B CHN1 PAK6 PREX1 STOM MCF2L PAK3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 CDC42BPB SRGAP2 ARHGEF10 CDC42BPA ARHGEF12 DEF6 PLEKHG2 KTN1 ARHGEF15 SHKBP1 DLC1 ARHGEF16 ARHGEF19 DIAPH3 VAV2 TIAM1 ARHGEF9 ARHGEF4 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF ARHGEF6 ARHGEF26 FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 MCF2 CDC42 FMNL3 FMNL1 FMNL2 LAMTOR1 TFRC SNAP23 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 SYDE1 ARHGAP42 OPHN1 ARHGDIB LBR GIT1 TMPO ARAP2 ARAP3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A ARHGAP17 ARHGAP21 PAK1 RACGAP1 PAK2 YKT6 PAK4 GIT2 CAV1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 NCAM1 ITGA5 ITGA9 EGFR CSNK2A1 CSNK2A2 PAK1 MAPK1 RAC1 CSNK2B NRP1 MAP2K1 MAP2K2 MAPK3 ITGB3 ITGB1 ITGA2B L1CAM VAV2 ITGAV MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal MGMT MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBC RPS27A UBA52 UBB ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans NCAM1 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TGFB1 TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 TNXB LRP4 ACAN TGFB2 LUM TGFB3 DSPP COL9A1 COL9A3 COL9A2 AGRN FMOD NCAN BGN DCN BCAN VCAN LAMA5 LAMA2 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN DAG1 ITGB3 ITGB1 ITGA2B ITGAV SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins H4C9 HDAC1 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I HDAC4 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 NUP205 CBX5 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis GCKR GCK PPP2R5D PRKACG PRKACA PRKACB PPP2CA PPP2CB HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 NUP37 PGK2 PFKL GNPDA1 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1 SUMO3 SUMO2 UBE2I SUMO1 RWDD3 UBA2 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes CREBBP SP1 BCL2 PDGFA MAFK AREG EGF NFE2L2 BCL2L1 EP300 NOTCH1 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN6 TNFRSF14 PTPN11 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR3 TAC3 TACR1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K NTF4 NTRK2 BDNF GAB1 PIK3R1 PIK3CA ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism GPT ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 HBEGF AREG EGF EGFR AKT2 CDKN1B MAPK1 CCND1 TGFA XPO1 FOS FOXO3 ELK1 SRF PTK2 AKT1 EREG MAPK3 UHMK1 BTC EPGN AKT3 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway ADCY5 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis GNG13 GNB2 PPP2R5B GNB1 PPP2R5A PPP2R5D PPP2R5C GNB4 GNB3 GNB5 GNGT1 GUCY1B2 GNGT2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PDE5A PLA2G4A PTPN11 FGR STIM1 KCNMA1 PPP2CA ORAI2 PPP2CB PECAM1 ORAI1 PDE9A PDE1B GNG3 PDE1A ITPR1 ITPR2 GNG2 ITPR3 GNG5 SRI GNG4 LRP8 GNG7 PDE11A KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 APOB TRPC7 NOS2 NOS3 PDE2A TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 PDE10A P2RX3 P2RX2 P2RX1 GNAS PPP2R1B PPP2R1A PTPN6 MAPK14 GNG10 GNG12 PPP2R5E GNG11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TRMT5 TYW2 TYW1 LCMT2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization CIDEC HILPDA CIDEA FITM1 HSD17B13 FITM2 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation UBC RPS27A RAB7A KPNA1 UBA52 ATP6V1H NOS2 VPS33B CORO1A HGS RAB5A KPNB1 UBB VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity UBC MAFK SKP2 RPS27A SKP1 RBX1 UBA52 FBXL17 BACH1 UBB CUL1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis OMA1 OPA1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ARHGAP10 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPK1 MAPK3 PPP2R1B PPP2R1A MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB ST6GALNAC3 MAN2A1 MGAT5 ST6GALNAC4 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC ST3GAL4 MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 ST6GAL1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors PTGDR PTGER4 PTGFR PTGER1 PTGIR TBXA2R PTGDR2 PTGER2 PTGER3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination HGS MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 TRIM25 NFRKB PSMD1 USP17L30 HIF1A YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 BRCC3 PSMA1 SNX3 RHOT1 PSMA2 RCE1 ZRANB1 UBA52 SIAH2 INO80 STAM PSMD12 TADA2B PSMD11 CYLD H2AC25 PSMD14 H2AC21 BAP1 PSMD13 WDR48 OTUD7A PSMA7 OTUD7B BABAM1 PSMB6 IFIH1 BABAM2 PSMB7 UCHL1 TRIM4 PSMB4 UIMC1 UFD1 PSMB5 ACTB IKBKG TOMM70 UBB RIPK2 PSMB2 ACTL6A PSMB3 JOSD2 UCHL3 UBC JOSD1 PSMB1 UCHL5 DDB2 RPS27A KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 RNF135 PSMC6 STAMBPL1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 MBD5 PSMC2 USP17L18 MBD6 USP17L17 TP53 USP9X USP17L19 MCRS1 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 IL33 USP3 USP2 MUL1 TGFB1 H2AC1 TGFBR1 CDC25A TGFBR2 FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 ABRAXAS1 SKP2 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B CDC20 NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 EP300 ASXL1 TNIP1 TNIP2 TNIP3 H2AC8 ASXL2 H2AC6 OTUD3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RHOA KDM1B AXIN1 APC UBE2D1 CDK1 BRCA1 BARD1 SEM1 CCNA2 CCNA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations POMK DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism GAMT GATM SLC6A7 SLC6A8 CKM CKMT1B SLC6A11 CKB SLC6A12 CKMT2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B EIF4E NUP214 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 UBB UBC RPS27A HSPA8 XRN2 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35C1 PDZD11 SLC25A5 APOD SLC25A4 SLC25A6 SLC35B3 LCN9 SLC35B2 SLC27A1 SLC35B4 SLC35D1 SLC35D2 LCN15 LCN12 SLC35A2 SLC35A3 SLC33A1 SLC5A6 ARL2BP LCN1 SLC29A4 SLC27A6 SLC28A2 SLC35A1 SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC27A4 ARL2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D CHRM2 HTR1A CHRM3 TAAR5 CHRM1 HTR1B CHRM4 TAAR2 CHRM5 ADRA2C HTR5A ADRA2B TAAR1 ADRA2A ADRB2 GPR143 ADRB3 HTR2B HTR2C ADRB1 ADRA1D HTR2A ADRA1B HTR4 ADRA1A HRH1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 INS MAPK1 MAPK3 PTPN1 PTPN11 SNW1 CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51D RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A YBX1 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 FGF16 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases LCK FYN FLT3LG FLT3 HCK SYK GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 F9 PROC F10 GGCX PROS1 FURIN PROZ F2 BGLAP GAS6 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA BCKDHB DBT DLD LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG LDLRAP1 AP2M1 CUBN CETP AMN ZDHHC8 APOA2 APOA1 LSR APOA4 PRKACG APOA5 NPC1 PRKACA SOAT1 PRKACB SOAT2 NPC2 APOE ANGPTL8 ANGPTL4 LPA CES3 ABCA1 SAR1B MTTP MYLIP LPL LMF2 LMF1 NR1H2 APOF APOC4 AP2S1 NR1H3 A2M LDLR GPIHBP1 FGF21 MBTPS1 APOBR APOC3 APOC2 AP2B1 APOC1 ANGPTL3 NCEH1 ALB ABCG1 P4HB MBTPS2 APOB UBA52 UBB UBC RPS27A VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 FLAD1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP1 MIP AQP11 AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions VASP FBLIM1 PXN TESK1 ILK PARVA PARVB FLNA FLNC ARHGEF6 RSU1 FERMT2 LIMS2 LIMS1 ACTN1 ITGB1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 ITCH PSMD14 SUFU BTRC PSMD13 NUMB PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP ELAC2 TRNT1 HSD17B10 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB ADCY1 ADCY8 CALM1 PRKAR1B PRKAR2B DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a MGAT2 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway FZD2 GNG13 FZD5 WNT5A FZD4 GNB2 PDE6G FZD6 GNB1 NFATC1 GNAO1 MAP3K7 GNB4 TCF7L2 GNB3 TCF7L1 GNB5 LEF1 GNGT1 TCF7 GNGT2 CTNNB1 PRKG2 TNRC6C MOV10 GNG3 AGO3 ITPR1 AGO4 ITPR2 GNG2 ITPR3 GNG5 GNG4 AGO1 GNG7 AGO2 TNRC6A GNG8 TNRC6B CAMK2A CALM1 PRKCA PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 GNG10 NLK PPP3R1 WNT11 PDE6B PDE6A GNG12 FZD3 GNG11 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing CPSF4 CPSF1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TYW5 NUP43 TYW3 RAE1 TRMT5 TYW2 NDC1 TYW1 RANBP2 SEC13 LCMT2 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TRMT10C PRORP ELAC2 TRNT1 HSD17B10 TP53RK CLP1 POP5 POP7 OSGEPL1 POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 RPP38 PUS3 METTL1 CSTF2 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU QNG1 TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 TSEN34 URM1 LAGE3 RPP14 TRDMT1 RTRAF TRMT10A ADAT1 NUP214 TPRKB TRMT1 ADAT3 TRIT1 ADAT2 XPOT TRMT6 FAM98B TRMT61A TRMT61B RAN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS HRAS SOS1 NTRK3 NTF3 NRAS ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 ATP2A3 SLC9B2 RAF1 ATP2A2 SCNN1G ATP2A1 SCNN1D SCNN1B SCNN1A ATP7A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPM1 ATP4B SRI TRPM2 ATP4A TRPM7 FXYD4 TRPM8 FXYD3 TRPM5 WNK1 TRPM6 FXYD2 TRPM3 WNK2 TRPM4 FXYD1 WNK3 TRPC7 FXYD7 TRPC5 FXYD6 MCOLN3 CUTC TRPC6 ATP2B4 RYR1 TRPA1 ATP2B3 RYR2 TRPC3 ATP2B2 RYR3 TRPC4 ATP2B1 UNC80 TRPC1 TRPV2 ATP7B TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN PDZD11 ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 TCIRG1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 ATP6V1E1 STOM ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 NEDD4L ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 SGK1 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 CAMK2B CAMK2D CAMK2A CALM1 CAMK2G UBA52 WWP1 UBB UBC RPS27A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBC RPS27A SMURF1 PARD6A CGN UBA52 F11R PRKCZ TGFB1 RHOA PARD3 TGFBR1 TGFBR2 FKBP1A ARHGEF18 UBB CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division PLK1 KIF23 PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 KIF20A ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling NRG1 PTK6 HBEGF EGF ERBB2 EGFR NRG3 EREG NRG4 BTC NRG2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism MOGAT3 MOGAT2 GPAM MOGAT1 PPP1CA ABHD5 FABP12 PRKACG GK3 GK2 PRKACA LIPE PRKACB AGMO GPAT2 DGAT2 GK DGAT1 PPP1CB FABP9 PPP1CC FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 FABP6 LPIN2 MGLL LPIN3 PLIN1 CAV1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP CITED1 CITED2 YEATS4 CITED4 TFAP2A TFAP2B WWOX EP300 TFAP2C TFAP2D TFAP2E ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP GPAM ERCC6 ANGPTL4 LPL RBM7 DPY30 CHD4 TBP EED SAP18 MTA2 CIDEC MTA1 MTA3 MED1 MORC2 ACSL1 ELOVL5 MED4 MED6 MED7 SCD ZNF141 HDAC1 ZNF382 SETD1B SETD1A SIN3A ZNF136 EHMT2 EHMT1 PHF20 ASH2L UBE2I ZNF28 AJUBA ZNF273 HCFC1 CCNH PPARGC1A PPARGC1B POLR2E ZNF264 POLR2F POLR2H POLR2K POLR2L GTF2H1 ZNF30 GTF2H2 ZNF257 GTF2H3 EZH2 GTF2H4 ZNF33A GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB ZNF331 MED16 ACTL6A MED17 MED12 MED14 MED13 KAT2B KAT2A MED10 ZNF324 MEN1 ZNF320 MED27 SIRT1 ZNF317 MED23 MCRS1 MED24 MED20 ABL1 ZNF547 ZNF224 MBD3 GATAD2B GATAD2A SUDS3 CDK8 CDK5 ZNF778 TADA3 ZNF454 OGT SIN3B WDR5 PSIP1 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 RB1 RBBP4 RBBP5 RBBP7 SMARCE1 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 CEBPA KMT2A H3C15 TDG RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 DEK H2AC20 ZNF418 HDAC3 GPS2 LIPE TBL1X ZNF354A DGAT2 NCOA1 ZNF649 FABP4 NCOR2 NCOR1 CHD3 TBL1XR1 LPIN1 MGLL CBX3 SUMO2 RRP8 SAP130 PLIN1 DPF1 HDAC2 PDK4 DPF2 KAT8 DPF3 SAP30BP HCFC2 SUZ12 WDR82 PAXIP1 PEX11A BAZ2A CBX5 KAT14 SETDB1 SS18L1 SMARCA5 ZZZ3 ARID1A TADA2A GSK3B ARID1B ZNF816 EZH1 PHF1 SUV39H1 SGF29 CD36 JARID2 NCOA2 ZNF610 SS18 NCOA6 SMARCB1 NCOA3 CCNC TET2 TET1 SF3B1 PPHLN1 BAZ1B TRIM28 PHF20L1 NR5A2 AEBP2 MTF2 TET3 PLIN4 PLIN2 MBD2 SMARCC1 MYBBP1A SMARCC2 MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 MTREX TASOR MBIP ZNF708 TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C SMARCA2 BCL7B SMARCA4 DNMT3B UBTF ZNF765 KDM6A DNMT3A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes PPARGC1A GCK FBXO32 G6PC1 CAT INS ABCA6 HDAC1 RETN POMC NPY SIN3A SOD2 PLXNA4 PCK1 NR3C1 FOXO4 ATXN3 TRIM63 SMAD2 SMAD4 AGRP SMAD3 FOXO6 FOXO1 HDAC2 IGFBP1 SIRT3 FOXO3 SREBF1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB AKT2 TSC2 TSC1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 HEXB ARSG HEXA ARSD B3GALNT1 GLB1L3 B3GALT4 M6PR GLB1L2 GALC GLA GLB1L GLB1 ARSB ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein PARP10 PARP6 GSK3A UBE2I PARP4 PARP16 GSK3B SUMO1 PARP9 PARP14 PARP8 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation NTRK1 KIDINS220 RAP1A CRK NGF BRAF YWHAB DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU FMO3 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death ITCH YWHAE YWHAQ YWHAG YWHAH UBE2L3 TNFSF10 UNC5A DAPK1 UNC5B DAPK2 DAPK3 FADD ELANE CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 APPL1 DFFB DFFA DBNL RIPK3 IL18 ACIN1 IL1A IL1B KPNB1 GAS2 PELI1 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 TICAM1 CHMP4C PKP1 CHMP4B CHMP4A LY96 SDCBP BMF MLKL BMX STK24 STK26 CHMP2B CHMP2A AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 CASP5 CASP4 PPP3R1 FLOT1 FLOT2 DNM1L DSP PDCD6IP OMA1 IRF1 OPA1 IRF2 DSG1 CHMP3 DSG3 CHMP6 CHMP7 PLEC UACA ADD1 BAK1 GZMB CDKN2A MAGED1 CTNNB1 MAPK8 BCL2L11 BAD CDH1 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 BBC3 UBC PSMB1 DSG2 RPS27A PRKN ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 PAK2 CASP9 CASP7 APAF1 DIABLO CASP3 XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC OGT TRAF2 HSP90AA1 KPNA1 CDC37 BIRC2 BIRC3 E2F1 TFDP1 TFDP2 ARHGAP10 AKT2 TP53BP2 OCLN TNFRSF10B TNFRSF10A STAT3 DYNLL1 DYNLL2 MAPK1 PPP1R13B TJP1 FAS FASLG MAPK3 PMAIP1 SATB1 CASP6 CASP1 APC STUB1 BAX TP63 BCL2 BCL2L1 SEM1 TP73 PTK2 AKT3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IFNG NFATC2 RUNX1 TNFRSF18 CTLA4 CBFB IL2RA FOXP3 IL2 CR1 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SRD5A3 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ST6GAL1 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 MVD ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1 AKT1 AKT2 AKT3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN NCSTN YWHAZ APH1B PSEN2 ADAM10 PSEN1 JAG1 APH1A DLL4 NOTCH4 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 AURKA PSMD14 PSMD13 PSMA7 PSMB6 FBXL18 FBXL7 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism HSPG2 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 IDUA EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 CTSL HPSE IDS THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOX1 TPO IYD DUOXA1 CGA DUOXA2 DUOX2 TSHB DIO1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 YAP1 TCF7L2 CDKN1A TCF7L1 SPP1 CDKN2A LEF1 TCF7 TGFB1 CCND1 MAMLD1 CTNNB1 BCL2L11 ITGAL RBPJ ITGA4 SMAD4 SMAD3 SMURF2 ZFHX3 SNW1 MYC SMURF1 HDAC4 TEAD1 SRC MDM2 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 BRD2 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 CCN2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 KRAS PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A KAT2B KAT2A EP300 JAG1 ADRM1 WWTR1 PSMC5 PSMC6 SEM1 PSMC3 RUNX1 PSMC4 PSMC1 RUNX3 PSMC2 TP53 MAML3 FOXO3 CBFB NOTCH1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions LCK FYN PECAM1 LYN INPP5D PTPN6 PLCG1 ITGB3 YES1 PTPN11 ITGAV LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants FLT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 ARHGEF6 BTK GNGT1 RHOA GNGT2 CDC42 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PAK1 PDPK1 PLCB3 PLCB1 GNG10 PLCB2 AKT1 GNG12 AKT3 GNG11 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 JAK2 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 P4HB PPIA SNRPA1 PAK2 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling CBL UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling PRKCA ADCY9 ADCY4 ADCY3 ADCY2 PLCG1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA CALM1 CAMK2G PRKCD DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets RPS6KA1 PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MEF2C MAPK7 MAPK14 MAPK11 MAPK1 ELK1 MAPK3 MEF2A RPS6KA3 RPS6KA5 PPP2R1B PPP2R1A RPS6KA2 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy PRKAG3 PLIN2 PLIN3 HSPA8 PRKAB2 PRKAA2 PRKAG1 PRKAB1 PRKAG2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions COL18A1 ITGA3 ITGB4 LAMA5 ITGA1 LAMA2 NID1 LAMB3 NID2 LAMC3 ITGA6 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 ITGA2 HSPG2 ITGA7 ITGB1 ITGAV BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism PDZD11 MCCC2 BTD SLC5A6 PC ACACA PCCA HLCS MCCC1 PCCB ACACB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 SEC11A SEC11C GATA4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events FOXM1 WEE1 LIN52 PLK1 CCNB1 EP300 CDC25C CENPF CDC25A RBBP4 CCNB2 LIN54 LIN37 MYBL2 LIN9 PKMYT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes H2BC9 H2AZ2 H4C9 PLK1 H2BC8 H2BC5 H2BC3 H3-4 CCNB1 H2BC1 H2AC20 RB1 CDK1 SET H2AX H2AB1 NCAPG2 H2AC19 SMC4 H2BC26 SMC2 H2AC14 H2BC12L NCAPH2 H2BC21 NCAPD3 MCPH1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT5A H3C15 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT6A STAT3 FBXL3 FBXL5 WRAP53 HDAC3 CCT2 KIF13A CCT3 SPHK1 SKIC2 CCNE2 TCP1 GBA1 CCNE1 DCAF7 CCT6B USP11 CCT7 FBXO4 AP3M1 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CCT8 CCT5 CCT4 FBXW2 NOP56 ARFGEF2 XRN2 GAPDHS FKBP9 TP53 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity PML TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 SRC TNRC6A TNRC6B CCND3 RUNX1 CCND2 CCND1 CDK6 CBFB PTPN11 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 CFTR STAM ACTB USP9X CCT6A TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 WWP2 WDR11 LETM1 TMEM59 VMA22 GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 ARMCX3 PKP4 RASAL2 STIP1 ACTG1 DDRGK1 PLXNA1 ANKRD26 NSFL1C CPD PLXNB1 ARHGAP11A ZNF512B CAPZB EFHD2 NCK2 DAAM1 WDR6 NCK1 DST PLEKHG6 NIPSNAP2 BLTP3B PARD6B SH3BP1 WHAMM WASF3 NDUFA5 PCDH7 SEMA4F SRGAP2 PTPN13 VAPB ATP6AP1 GOLGA3 CKB BAIAP2L2 KCTD13 FRS2 TMEM87A DIAPH1 GRB7 PIK3CA PIK3R3 SCFD1 DIAPH3 ITGB1 SPTBN1 CCDC88A ANLN FAF2 SOS1 KIF14 SH3RF1 NUDC AKAP12 HINT2 RAC2 MUC13 RHOG PIK3R2 RHOH PIK3R1 RHOF RHOC RHOJ RHOD RHOU RHOV RHOQ RHOA SAMM50 RHOB EMC3 MTX1 CAVIN1 MYO9A TRIP10 RTKN PRAG1 SYDE2 BASP1 ALDH3A2 ELMO2 DDX4 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 CDC42 PLD2 RHPN1 RHPN2 FAM83B ACBD5 MACO1 ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 DLG5 PICALM FMNL3 SRC DOCK5 DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 SOWAHC MTR TNFAIP1 RND2 RND3 RND1 CKAP4 SENP1 ZAP70 GFOD1 ALS2 PEAK1 NDUFS3 DOCK2 DOCK1 CCDC187 MOSPD2 FAM169A ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CSK FRS3 JAG1 LCK DBT CLTC HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 ARHGAP21 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 WAS PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 ARL13B RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 PRKCB CREBBP RUNX1 LGALS3 CBFB REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism WDR26 PDHB RMND5B LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GID4 GID8 UBC RPS27A PDK4 DLD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 CYP11B1 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC E2F1 RBBP4 E2F3 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PRKCB PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 PRKCA CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 PRKCG FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death JUN PRDX2 H2BC9 PRDX1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 CDC25B CDC25A LMNB1 BCL2L11 FASLG CDK5R1 RIPK1 CDK5 SUZ12 YWHAE TRAF2 EED CDC25C FADD GSDME C1QBP RBBP4 EZH2 GOLGA2 SOD2 CAPNS1 RIPK3 CAPNS2 CAPN2 RBBP7 CAPN1 CAST PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MLKL H2AC6 H2AC7 H2BC17 APP DNMT3B H2BC12 H2BC13 TRADD H2BC14 H2AJ DNMT3A H2BC15 TP53 CASP8 H2BC11 FOXO3 H3C15 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU PHB1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGF ERBB2 EGFR PLCG1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation FBLN5 LOXL1 ITGA5 LOXL2 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 FURIN MFAP5 BMP4 MFAP4 LOX MFAP3 MFAP2 FBN1 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization SGTA PEX10 PEX12 TOMM20 GFER GDAP1 PEX13 PEX14 OTC DHRS4 NUDT7 VAPA TOMM7 CRAT TOMM5 TOMM6 NOS2 STX5 CAT SLC25A4 SLC25A6 IDE PMPCB PMPCA SLC27A2 PECR SAMM50 ZFAND6 TOMM22 MTX1 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 SCP2 CHCHD7 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 CMC4 CMC2 PAM16 ECH1 PIPOX BCS1L GNPAT ACBD5 ACOT2 STX1A ACOT4 COX19 COX17 PEX11B ATP5MC1 TIMM50 BAG6 PITRM1 GRPEL1 ABCD3 GRPEL2 UBE2D2 LDHD UBE2D3 OTOF HMOX1 HACL1 HAO1 CYC1 DECR2 HAO2 DNAJC19 COA4 PRNP FIS1 EPHX2 IDH1 TYSND1 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 UBE2D1 AMACR DAO HSPD1 PXMP2 PXMP4 ACO2 ABCD2 UBA52 CROT HSCB SERP1 SEC61G TIMM17A TIMM17B GET1 SEC61B GET3 EMD ABCD1 COA6 GET4 CAMLG TIMM23 PEX2 TIMM22 HSPA9 PEX1 TIMM21 BAAT UBB TOMM70 PEX7 SLC25A17 ACOX2 ACOX1 UBC PEX3 EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PAOX NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 APP HSD17B4 TIMM10 DDO HMGCL ATP5F1A ATP5F1B USP9X UBL4A TIMM8B ATAD1 PEX16 TIMM8A PEX19 MTX2 IDH3G DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors F7 F9 PROC F10 GGCX PROS1 PROZ F2 BGLAP GAS6 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L PRKACA KIF7 PRKACB WDR35 IFT88 SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 GLI3 GLI2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 GNAS PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 BTRC NUMB PSMD13 OFD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PRKAR1B PSMC5 PRKAR2B PSMC6 PRKAR1A SEM1 PSMC3 PRKAR2A PSMC4 PSMC1 PSMC2 SKP1 CUL1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis AP2A1 AP2A2 AP2M1 ARF1 ATP6V1H CD4 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B HCK PACS1 ELMO1 RAC1 LCK CD28 FYN PAK2 DOCK2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction LCK RAC1 FYN PAK2 HCK DOCK2 ELMO1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 JUN PCNA COX5B COX5A PERP NPM1 COX6C TTC5 CCNG1 PRDM1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 NDRG1 HIGD1C CNOT10 CNOT11 TAF4B YWHAE PRR5 DYRK2 CHD4 TRIAP1 PIDD1 YWHAQ YWHAG ZNF385A YWHAH TBP TMEM219 TAF9 TAF1L AURKA MTA2 TAF15 TAF12 TAF13 TAF11 CARM1 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 PRDX2 PRDX1 PLK3 PRELID1 CDKN1A HDAC1 CDKN2A PLK2 CDK2 CDK12 CDK13 PRKAA1 PRKAA2 MDC1 ATF2 BTG2 MT-CO1 PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 RPTOR NOC2L CHM STK11 TNRC6C MOV10 MLST8 TAF7L SLC38A9 AGO3 ING5 AGO4 ING2 PRKAB2 PIP4P1 AIFM2 AGO1 TNKS1BP1 AGO2 TSC2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC MT-CO2 BRD1 MT-CO3 ELOB RHEB RRAGB ELOC RRAGD LAMTOR2 AKT1 MEAF6 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SFN BRD7 YWHAZ CCNH POLR2A POLR2B PRELID3A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K TIGAR POLR2L GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 POU4F2 SUPT5H HIPK2 GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB BBC3 UBC DDB2 RPS27A CASP10 CSNK2A1 MAPK14 MAPK11 CSNK2A2 CNOT6L TAF9B CSNK2B IGFBP3 KAT6A TP53 APAF1 CYCS USP7 PLAGL1 PMS2 USP2 RICTOR BID MBD3 MAP2K6 FANCI GATAD2B GATAD2A FANCC CNOT4 CNOT6 CNOT7 BCL6 CDK5 CNOT1 STEAP3 CNOT2 CNOT3 MDM2 MDM4 CNOT8 CNOT9 CCNT2 SESN3 PTEN SESN2 KMT5A GPX2 BNIP3L CDC25C RNF34 CDKN1B NLRC4 MSH2 E2F1 RBBP4 MAPKAPK5 DAXX TFDP1 RBBP7 CCNE2 TFDP2 RFFL CCNE1 PPP2R1B TXNRD1 PPP2R1A CPAP PML TAF10 TP53RK EP300 AKT2 TP53AIP1 CHEK2 SMYD2 COX7A2L PDPK1 TXN NUAK1 TP53BP2 BANP GADD45A BCL2L14 TPX2 ZNF420 BRPF1 BRPF3 TNFRSF10C TNFRSF10B PRMT5 TNFRSF10A PPP2R5C PRMT1 TNFRSF10D RGCC SGK1 PIN1 BIRC5 MLH1 PPP1R13B COX4I1 FAS COX4I2 PPP1R13L CDK5R1 AURKB PPP2CA PPP2CB FANCD2 COXFA4 RABGGTB COX7A2 RABGGTA COX7A1 CHD3 RRM2B PMAIP1 TP53INP1 HDAC2 TP53I3 E2F4 JMY E2F7 E2F8 CASP6 CASP1 CASP2 RBL2 RBL1 GPI CCNK CCNB1 GLS2 GLS CDK1 ARID3A BAX BLM TP63 MRE11 BRCA1 CTDP1 ELL WRN BRIP1 CCNT1 KAT5 SUPT4H1 ELOA EXO1 CHEK1 NELFB NELFCD RBBP8 NELFA NBN NELFE TOPBP1 L3MBTL1 ATRIP SUPT16H BARD1 CREBBP RFC5 RMI2 ELOA2 RFC3 SSRP1 CDK9 RFC4 RMI1 TCEA1 PCBP4 RFC2 TOP3A RPA1 HUS1 RPA2 CRADD RAD50 RAD51D TP73 COX7B RPA3 RAD17 FOS RAD1 CCNA2 ATM CCNA1 DNA2 COX7C RAD9B RHNO1 ATR COX8A RAD9A COX8C AKT3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D KIF17 GRIN1 RPS6KA6 DLG1 CASK GRIN2A LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIA3 CALM1 CAMK2G GRIA4 GRIN3B GRIN3A APBA1 CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 NBEA RPS6KA3 RPS6KA2 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity USP7 USP2 RICTOR TTC5 CCNG1 MBD3 PRDM1 MAP2K6 GATAD2B GATAD2A CDK5 MDM2 MDM4 TAF4B PRR5 DYRK2 CHD4 KMT5A ZNF385A TBP TAF9 TAF1L RNF34 AURKA MTA2 TAF15 TAF12 RBBP4 TAF13 MAPKAPK5 TAF11 DAXX RBBP7 TAF8 TAF7 RFFL TAF6 TAF5 PPP2R1B TAF4 PPP2R1A TAF3 TAF2 PML TAF1 PIP4K2A TAF10 TP53RK PIP4K2B EP300 PIP4K2C AKT2 CHEK2 SMYD2 PDPK1 NUAK1 TP53BP2 BANP MAPKAP1 TPX2 BRPF1 BRPF3 PRMT5 PLK3 PPP2R5C HDAC1 CDKN2A SGK1 PIN1 CDK2 PPP1R13B PPP1R13L PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 PPP2CA NOC2L STK11 PPP2CB MLST8 CHD3 TAF7L ING5 ING2 PRKAB2 PIP4P1 TP53INP1 HDAC2 PRKAB1 MTOR JMY BRD1 AKT1 MEAF6 BRD7 UBA52 CDK1 HIPK1 POU4F1 BLM POU4F2 MRE11 TP63 HIPK2 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 SUPT16H L3MBTL1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CSNK2A2 TAF9B RAD50 CSNK2B TP73 KAT6A RPA3 RAD17 TP53 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A AKT3 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation LTF REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity XIAP RNF146 TNKS PREX2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 STUB1 PSMA6 PSMA3 TRIM27 PSMA4 WWP2 PSMA1 NEDD4 MKRN1 PSMA2 FRK UBA52 PSMD12 USP13 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A AKT2 ADRM1 CSNK2A1 PSMC5 OTUD3 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 AKT3 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 CYP17A1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants FLT3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 GIT1 CALM1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMA1 KCNMB1 CHRNA9 CHRNA10 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MLH1 RPA3 EXO1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) STPG4 METTL23 YAP1 UHRF1 H2BC9 DPPA4 H2AZ2 DPPA3 H4C9 DPPA2 H2BC8 ZFP36L2 H2BC5 LEUTX H2BC3 PAIP1 NPM2 H2BC1 KDM4E TPRX1 AICDA SRPK1 H2AC20 H1-8 TPRX2 ZSCAN4 HIRA CNOT4 CNOT6 CNOT7 EIF4E DICER1 EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 CNOT11 KDM5B TEAD4 PABPN1 PABPC1 TET3 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 BTG4 CNOT6L EIF4A2 H2BC12 KDM5A H2BC13 EIF4A1 H2BC14 TUT7 KDM6A H2AJ TUT4 H2BC15 EIF4G1 DUX4 TP53 PABPN1L H2BC11 TPRXL EIF4A3 DUXA DUXB DIS3L2 KDM6B PRM2 PRM1 H3C15 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA1 GNG13 GNB2 GNB1 AP2A1 ADCY9 GNB4 GNAL GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 CHRNA9 RASGRF2 PRKAR1B PRKAR2B PRKCB PRKAR1A RAC1 HRAS PRKAR2A PRKX PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF9 NRAS GRIP1 MAPK1 GNAT3 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 CHRNA1 CHRNA3 PRKAA1 CHRNA2 PRKAA2 MAPK3 CHRNA5 CHRNA4 CHRNA7 PRKAG1 CHRNA6 PRKAG2 EPB41L1 PRKAG3 TSPAN7 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK4 GRIK1 PRKAB2 GRIA1 GRIK2 GABRR3 CAMK2B GRIA2 GABRR2 GABRR1 CAMK2D NPTN SRC ACTN2 PRKAB1 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B NRGN PICK1 GRIN2D GNAI3 AKAP5 GRIN1 DLG1 GNAI1 GRIN2A NCALD DLG2 GNAI2 DLG3 CHRND LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE PRKCA CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 GIT1 KCNJ16 GLRB CAMK4 CAMKK1 CAMKK2 KPNA2 PRKCG GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade RHO PDE6G CNGA1 GNB1 GNAT1 SLC24A1 SAG PDE6B CNGB1 GNGT1 PDE6A DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 EED H2BC3 H2BC1 H2AC20 GSDME RBBP4 EZH2 RBBP7 PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock FBXL3 CDK5 RORC RORA RORB SMARCD3 BTRC CARM1 PPP1CC NAMPT EP300 MED1 KMT2A RXRA SERPINE1 HDAC3 NR1D1 NRIP1 TBL1X BMAL1 NCOA1 ATF2 NCOR1 MEF2C TBL1XR1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PPARGC1A PSMA6 PSMA3 UBE2D1 NCOA2 PSMA4 PSMA1 NCOA6 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PPP1CA PSMD13 PSMA7 PSMB6 CRTC2 PSMB7 CRTC3 CRTC1 CSNK1D PSMB4 CPT1A PPP1CB SIK1 PSMB5 CSNK1E CLOCK NPAS2 UBB HELZ2 PSMB2 RAI1 PSMB3 CREBBP BHLHE40 UBC CHD9 BHLHE41 PSMB1 RBM4 DBP RPS27A TFEB KLF15 FBXW11 CRY2 CRY1 AVP CIPC ADRM1 CSNK2A1 FBXL21P NOCT TGS1 PSMC5 CSNK2A2 MEF2D PSMC6 SEM1 PER2 PSMC3 PER1 PSMC4 F7 PER3 PSMC1 CSNK2B PSMC2 BMAL2 SIRT1 SKP1 SREBF1 CUL1 PPARA REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity GJA1 TJP1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 PIK3R1 PIK3CA SRC IRS1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L KCNJ11 SLC5A1 ABCC8 SLC5A2 ABCC9 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 SLC67A1 RNF185 SLC26A3 APOA1 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 VCP SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC6A19 SLC27A4 SLC36A2 SLC6A14 SLC7A7 SLC7A9 GCKR GCK ABCA1 ABCG8 ABCG5 ABCA3 PSMD8 PSMD6 HK1 PSMD7 PSMD2 PSMD3 PSMD1 NUP214 SLC5A5 PSMA5 SLC35C1 PSMA6 CFTR PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 SLC24A1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SLC17A5 RPS27A SLC9A6 AVP ADRM1 SLC9A9 PSMC5 PSMC6 SEM1 SLC35A1 PSMC3 PSMC4 PSMC1 PSMC2 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes CREBBP ATF4 MAFK NFE2L2 EP300 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARL13B INPP5E PDE6D CCT2 CCT3 SMO TCP1 ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP HDAC6 BBIP1 RHO RAB11A ATAT1 TTC8 CNGB1 RAB8A SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CCND1 MAMLD1 RBPJ TNRC6C MOV10 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B ELANE E2F1 E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation BRD7 BRPF1 BRPF3 HDAC1 MTA2 PIN1 RBBP4 MBD3 MAP2K6 RBBP7 GATAD2B GATAD2A PML CHD3 ING5 PIP4K2A ING2 PIP4K2B PIP4P1 EP300 PIP4K2C AKT2 HDAC2 BRD1 KAT6A TP53 CHD4 MEAF6 AKT1 AKT3 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM NCBP1 NCBP2 FGF1 POLR2A FGF2 POLR2B FGFR2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB ZFP36 DCP1A EXOSC7 EXOSC6 EXOSC5 TNPO1 EXOSC4 DIS3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) PCNA YY1 RUVBL1 PARP1 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 RBX1 NFRKB CCNH ACTR5 RAD23A ACTR8 RAD23B CETN2 UBA52 INO80 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB UBB TFPT ACTL6A LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 DDB2 POLD1 RPS27A POLE POLD2 PIAS3 RFC2 RFC1 PARP2 USP45 LIG3 RPA1 RNF111 CHD1L DDB1 RPA2 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 COPS6 COPS5 MCRS1 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD NCAN CSPG4 CHST3 BGN DCN BCAN VCAN CSPG5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID BBC3 BCL2 BCL2L11 STAT3 PMAIP1 BCL2L1 BAD BMF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism ACSS3 BDH2 BDH1 HMGCL OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development YAP1 RBM14 HES1 BGLAP ABL1 RB1 MAF HDAC3 COL1A1 MAPK1 HDAC6 SP7 IHH UCMA MAPK3 GLI3 SMAD1 GLI2 SMAD4 HEY1 HEY2 SMAD6 HDAC4 SRC WWTR1 YES1 SATB2 CBFB ZNF521 AR OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency OTC HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs FKBP5 HSP90AA1 DYNLL1 DCTN6 DCTN5 ACTR1A HSP90AB1 DCTN1 DYNLL2 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 CAPZA3 DNAJA4 DNAJA2 CAPZA2 DYNC1I2 FKBP4 NR3C1 ACTR10 STIP1 HSPA1B CAPZB DYNC1LI1 DYNC1I1 DYNC1LI2 DCTN2 HSPA8 DYNC1H1 CAPZA1 DCTN3 HSPA1A PGR AR REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling IFNG JAK2 JAK1 SOCS3 PTPN6 PIAS1 PTPN1 SOCS1 SUMO1 IFNGR1 IFNGR2 PTPN11 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD CSPG4 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 B3GAT3 CSPG5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 YAP1 BGLAP ABL1 IHH NR3C1 ESRRA STAT1 MSX2 SMAD1 SMAD4 ESR1 BMP2 ZNF521 RBM14 RB1 MAF HDAC6 SKP2 CDK4 DLX5 DLX6 AKT2 SOX9 RUNX1 TWIST2 TWIST1 CBFB ITGA5 CDKN1A HDAC3 MAPK1 CCND1 SP7 MAPK3 NKX3-2 GLI3 GLI2 HAND2 PPM1D SMURF1 SMAD6 HDAC4 SRC SATB2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B AR PSMA5 STUB1 PPARGC1A PSMA6 PSMA3 PSMA4 PPARGC1B PSMA1 CCNB1 PSMA2 HES1 LGALS3 UBA52 PSMD12 PSMD11 CDK1 COL1A1 PSMD14 WWP1 BAX PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UCMA PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 HEY2 HIVEP3 ADRM1 WWTR1 YES1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 ITGBL1 PSMC2 SKP1 MMP13 CUL1 AKT3 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB IKBKB SQSTM1 UBC MYD88 RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR PRKCI UBB RIPK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 SKP2 CCNE2 KPNB1 PRIM2 CCNE1 PRIM1 POLA1 H2AX POLA2 LIG1 H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 KPNA6 POLRMT POLG2 RNASEH1 FEN1 MCM10 POLG TWNK DBF4 MGME1 EXOG RPA4 SSBP1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 TOP3A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation PCNA GINS1 GINS2 CDC45 GINS3 GINS4 PRIM2 PRIM1 POLA1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 MCM7 MCM8 RPA3 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RRAS FES PLXNA2 TLN1 PIP5K1C FARP2 PLXNA3 RAC1 FYN RND1 PLXNA4 NRP1 PLXNA1 SEMA3A ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization PERP PI3 CAPNS1 CAPN1 PKP1 DSP DSG1 DSG3 LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G DSG2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 FURIN PCSK6 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KRT12 KLK14 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 JUP KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PKP4 LELP1 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 CELA2A KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate DCXR AKR1A1 SORD CRYL1 XYLB IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AZ2 H4C9 PRMT6 PRMT5 SMARCB1 SMARCD1 PRMT1 SMARCD2 SMARCD3 H2AC20 H2AC1 H2AC25 H2AC21 CCND1 JAK2 SMARCC1 SMARCC2 PRMT7 PRMT3 CARM1 RBBP7 WDR77 COPRS CDK4 ARID2 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2AC14 RPS2 H3C8 H2AC8 H2AC6 H2AC7 SMARCA2 ACTL6B SMARCA4 H2AC17 H2AC12 H2AJ DNMT3A WDR5 ARID1A ARID1B H3C15 PBRM1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IPPK IPMK IP6K1 IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR10 MTMR2 MTMR12 PIK3C2A MTMR4 MTM1 PIK3R4 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3C3 VAC14 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation PTK6 PTPN1 SRMS EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis RASGRP2 RASGRP1 ITPR1 ITPR2 MGLL ITPR3 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 TRPC7 ABHD12 PRKCH TRPC6 DGKZ DGKQ PRKCQ TRPC3 PRKCE DAGLB DGKK DGKI DGKH PRKCD RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle RXRA MID1IP1 SLC22A5 SLC25A20 CPT1B PPARD PRKAB2 CPT1A PRKAA2 CPT2 PRKAG2 THRSP G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events TIAM1 GNG13 ARHGEF9 SOS1 OBSCN GNB2 ARHGEF3 ARHGEF4 GNB1 ARHGEF1 ARHGEF2 ARHGEF7 GNB4 SOS2 GNB3 RHOC ARHGEF5 NGEF GNB5 ARHGEF6 ARHGEF26 GNGT1 RHOA KALRN RHOB FGD1 FGD2 GNGT2 ROCK1 GNA13 ROCK2 FGD3 ABR FGD4 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 GNG3 GNG2 GNG5 GNG4 TBXA2R GNG7 GNG8 BTK GNA12 PLXNB1 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 GNG10 ADRA1D ARHGEF16 ARHGEF19 ADRA1B ARHGEF18 VAV1 ADRA1A VAV2 GNG12 TIAM2 GNG11 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID IKBKB NFKB2 RELA CHUK NFKB1 NFKBIA IKBKG SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 EHHADH ABCD1 DECR2 SLC27A2 ACOT4 ACAA1 ACOT8 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling DNMT1 SIN3A STAT3 PRDM1 EP300 CD274 HDAC1 IL2RG HIF1A HDAC2 HDAC3 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PIK3CB STRN SOS1 KDR FIP1L1 STAT3 PIK3R2 PIK3R1 NRAS PDGFRA HRAS WDR48 STAT1 PIK3CA KANK1 ETV6 GOLGA4 BIN2 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 MAP2K5 MAPK7 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid RXRA PPARD DHRS4 PDHB RXRG PDK3 DLAT RXRB PDK2 PDK1 PDHX PDHA2 PDHA1 RARG FABP5 CYP26A1 CYP26B1 CYP26C1 ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 PDK4 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 RARB ALDH8A1 RARA DLD ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) RXRA GGPS1 SCD CYP51A1 FASN LSS SREBF2 SQLE NCOA2 MTF1 DHCR7 NCOA6 SMARCD3 ACACB GPAM NFYA MVD NFYB NFYC TBL1X CARM1 NCOA1 HELZ2 CREBBP CHD9 SP1 TBL1XR1 ACACA MED1 TGS1 IDI1 MVK ELOVL6 TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling NEDD4L STUB1 PMEPA1 BAMBI STRAP UBA52 TGFB1 TGFBR1 TGFBR2 PPP1CA USP15 PPP1R15A PPP1CB PPP1CC UBB UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD3 SMURF2 SMAD7 SMURF1 XPO1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism ARSB GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 GBA1 NEU2 ENPP7 NEU3 ARSA SUMF2 SUMF1 NEU1 ASAH1 ASAH2 ARSL ARSJ ARSK PSAP ARSH ARSI CTSA ARSF HEXB ARSG HEXA ARSD GLB1L3 M6PR GLB1L2 GALC GLA GLB1L GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 EGF HES1 EGFR WWC1 NEURL1B UBA52 DLGAP5 HES5 PLXND1 APH1A PTCRA DLL4 MIB2 PSENEN PBX1 NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 TACC3 MAMLD1 PSEN1 STAT1 UBB RBPJ CREBBP UBC MAML2 FABP7 MAML1 RPS27A YBX1 HEY1 KAT2B KAT2A EP300 JAG2 SNW1 HEY2 JAG1 DLL1 MAML3 NOTCH3 NOTCH1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS AP2A1 AP2A2 FURIN SAP30L AP2M1 ATP1B3 ATP1B2 ROCK1 ATP1B1 ROCK2 CUL3 IGHV3-23 ARID4A IGLV MBD3 COMT IGLV2-8 NR3C1 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 GATAD2B IGHV3-30 RIPK1 GATAD2A IL1R1 SUDS3 IGHV3-33 AP2S1 IGKV1D-39 ZBP1 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 FXYD4 PHF21A FXYD3 CD79B IGLV2-11 FXYD2 CD79A IGLV1-40 FXYD1 IGLV1-47 IGLV6-57 FXYD7 IGLV2-14 FXYD6 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CHD4 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV SAP18 IGKV2-29 IGKV2-28 IGLC3 ATP1A4 BLNK ATP1A3 HMG20B MTA2 IGLC1 ATP1A2 FNTB IGLC2 S1PR1 JAK3 ATP1A1 SIGMAR1 RBBP4 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 REST IGLV3-19 MTA3 IGHV2-70 RBBP7 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FNTA BRD4 CRBN IGLC7 IGHV3-53 IGKV5-2 NCK1 STAT2 IGLC6 IL6R IGKV1-5 IMPDH1 IMPDH2 PDCD1 ITGB1 VAV1 TLR9 SOS1 HDAC1 HSP90AB1 KDM1A PTGES3 FKBP4 IFNGR1 IFNGR2 ITGA4 CHD3 HDAC2 FKBP1A KEAP1 RBX1 BTK JAK2 TUBB ARID4B JAK1 SAP30 TYK2 NFE2L2 SYK SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling RRAS PLXNB1 ERBB2 RHOC ARHGAP35 SEMA4D RHOA LIMK2 RHOB LIMK1 RAC1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MET MYH10 MYL9 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 FKBP5 HTT HDAC1 GAD1 SGK1 GAD2 HDAC3 GPS2 SIN3A PRKACA MET TBL1X DGCR8 PTPN1 AURKB NCOR2 TNRC6C GPRIN1 MOV10 NCOR1 MEF2C TBL1XR1 AGO3 IRAK1 AGO4 RBFOX1 CAMK2B GRIA2 AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A GRIN2B PTEN SLC2A3 GRIN2A TRPC3 OPRM1 SST CALM1 CAMK2G PTPN4 CRH OPRK1 LBR HIPK2 PVALB FOXG1 SOX2 MOBP GAMT DLL1 CAMK4 BDNF PPARG CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation MIB2 ITCH HSPA5 SAR1B TLR1 S100A9 S100A8 TLR2 STX4 UBE2L3 CD14 BTRC TLR4 LY96 RNF111 UBE2V2 LRR1 HMGB1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SEC31A SOCS1 HACE1 SIAH1 LNPEP MEX3C IKBKB UBAC1 FBXL8 MYD88 CD207 CALR CANX FBXL4 DZIP3 RNF220 DET1 LRSAM1 CTSS MRC2 TRIM9 MRC1 ARIH2 LRRC41 VAMP8 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 TLR6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 PSMB8 PSMB9 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 NCF1 KLHL5 PSMA5 RLIM NCF2 PSMA6 TRIP12 NCF4 PSMA3 KBTBD7 SNAP23 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 BTK RNF19B UBE3A PSMD12 SEC61G UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 SEC61B NPEPPS PSMD13 RNF19A PSMA7 PDIA3 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 S100A1 UBE2E3 CYBB TRIM4 PSMB4 FBXO17 TAP2 CYBA PSMB5 FBXO15 IKBKG UBE2E2 TAP1 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 VAMP3 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 PSME2 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 CUL3 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 RBBP6 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 SMURF2 ASB13 B2M ASB14 ASB11 RNF6 ASB12 HLA-A RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 SEC13 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 BECN1 SEC24D ASB2 ASB3 SEC24C SKP2 ASB1 CDC20 SOCS3 PIK3C3 ITGAV SH3RF1 ITGB5 PIK3R4 FBXO32 CHUK MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 CD36 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FGB FGA FGG FBXW11 FBXL21P SEM1 SKP1 CTSV CTSL CUL1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis ENO1 TRIM27 KPNA1 UBA52 ATP6V1H MAPK1 CTSG DUSP16 VPS33B CORO1A PGK1 HGS RNF213 RAB5A KPNB1 MAPK3 UBB UBC RPS27A RAB7A B2M SFPQ MRC1 NOS2 LTF TLR2 GSK3A INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA AREG EGF EGFR EREG BTC EPGN SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF23 FGF4 FGFR1 FGF6 FGF9 FGF20 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events FURIN RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX ACE2 MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 ANO8 CSNK1A1 PARP14 ANO9 PARP8 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 UBA52 ST6GALNAC3 ST6GALNAC4 TMPRSS2 SRPK2 ANO10 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors CALCRL ADM2 ADM IAPP RAMP1 RAMP2 CALCA RAMP3 CALCB CALCR DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC TCN2 CD320 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle FURIN CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TBP NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 RANGAP1 TAF7L ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A F9 F10 TPST2 TPST1 F8 F2 VWF NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COL4A2 COL4A1 FTH1 SCGB3A2 MASP1 CALR FTL COL1A1 APOA1 COL1A2 APOB APOE COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus BANF1 XRCC6 XRCC4 KPNA1 XRCC5 LIG4 PSIP1 PPIA HMGA1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MKRN1 CDKN1A AKT2 TSC2 MDM2 CDKN1B CHUK AKT1S1 GSK3A AKT1 CASP9 BAD GSK3B AKT3 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones H2BC9 H4C9 H2BC8 H2BC5 H2BC3 SAP30L H2BC1 HDAC1 H2AC20 H2AC1 HDAC3 KDM1A GPS2 ARID4A MBD3 TBL1X GATAD2B GATAD2A SUDS3 NCOR2 CHD3 BRMS1 NCOR1 TBL1XR1 HDAC2 PHF21A H2AC17 H2AC12 CHD4 RCOR1 H2BC18 SAP18 HMG20B HDAC8 MTA2 H2AC25 H2AC21 RBBP4 MTA1 REST ARID4B MTA3 RBBP7 SAP30 H2AC19 H2BC26 H2AC14 H2BC21 HDAC10 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 EGFR CDC37 NRAS PLCG1 NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification SEL1L RPN2 ERLIN1 TUSC3 PDCD1LG2 ERLIN2 B3GNT3 RPN1 SPOP MAGT1 MIB2 RNF185 CCND1 CUL3 VCP OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 DERL3 DERL1 OSTC DERL2 RNF5 ERLEC1 STT3A OS9 STT3B PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B YWHAG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PDCD1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 COPS5 CUL1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN CSPG4 BGN DCN BCAN VCAN CHST14 CSPG5 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function OPN1SW E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 H2BC3 PEX14 H2BC1 HLA-B RNF20 VCP UBE2J2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC UBA52 PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PEX2 UBB UBC RPS27A UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2B UBE2N PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 CRY2 CRY1 CSNK2A1 CSNK2A2 PER2 PPP1CA PER1 PER3 CSNK2B CSNK1D PPP1CB CSNK1E PPP1CC HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT SHH IHH DHH TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling CDC42 DCC NTN1 TRIO NCK1 SRC RAC1 ABLIM1 WASL ABLIM2 PTK2 ABLIM3 DOCK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 HSPG2 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L CD209 SDC4 SDC2 SDC3 CDK8 AGRN TLR3 IRF3 GPC1 IFNAR1 GPC3 MAVS GPC2 GPC5 GPC4 GPC6 RIGI TLR6 ELOB TLR2 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 CD14 BECN1 TLR7 IFIH1 JAK1 TLR4 UBB MED16 BCAP31 MED15 MED17 CREBBP UBC MED12 TYK2 MED14 MED13 RPS27A MED10 STAT2 EP300 CUL5 LY96 MED1 MED30 MED31 MED8 MED4 MED27 MED6 MED26 MED7 H2BC15 MED23 UBE2L6 MED25 IFNA5 HERC5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 HSPD1 TFAP2A NPM1 MYBL2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 APEH RPL7A RPL18A HEMK2 RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 TRMT112 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 CHAC1 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux RXRA CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB APOD APOE TBL1X NCOA1 ABCA1 ABCG8 KDM4A ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 EP300 APOC2 APOC1 AGO1 AGO2 TNRC6A ABCG1 TNRC6B NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors NKX2-5 KAT2B WWTR1 HIPK1 HIPK2 MME NPR1 NPR2 TBX5 NPPC CORIN CES1 GATA4 NPPA CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic PCNA YWHAE EML4 CDCA5 MYBL2 NCAPG YWHAG ARPP19 NCAPH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 CHMP3 CHMP6 CHMP7 CDC7 FBXL18 FBXL7 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH LYN CDKN2B CDK7 MNAT1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 ABL1 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 JAK2 PPP1CB HJURP RFC5 PPP2R2A RFC3 PPME1 GTSE1 RFC4 BORA FKBPL RFC2 FBXW11 OPTN OBI1 HMMR RPA1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B TICRR MCM7 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MYC PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 HAUS8 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 KMT5A HSP90AA1 CDC25C CDKN1C RB1 CDKN1B CCND3 FZR1 CCND2 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX CPAP LIG1 MAX H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 RCC1 H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 GSK3B PHLDA1 AKT3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation UPK1A EPCAM METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids ACSS3 MED19 SLC22A5 ABCB4 MED18 MED11 AGPAT2 SLCO1B1 SLCO1B3 MED9 MED29 MED28 MED22 MED21 THRSP GPAM GAL3ST1 CERK GBA3 CDK19 GBA2 SMPD3 SMPD2 STS SMPD4 MED13L GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLA2G4A SUMF1 B3GNT5 GGT5 B4GALT6 B4GALT5 ASAH1 ASAH2 ABCB11 FUT2 FUT1 UGCG UGT8 ARSL ARSJ GGT1 ARSK VDR PSAP ARSH ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC CYP2C9 NDUFAB1 CYP2C8 CYP2U1 CYP4F2 CARM1 CYP1A2 RAB5A KPNB1 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PIP4K2A NSDHL PIP4K2B LIPI PIP4K2C CYP2D6 LIPH FDXR SULT2A1 MED1 STARD3 BMX ACOT9 STARD4 STARD5 ACOT7 MED8 MECR STARD6 MED4 STARD7 MED6 MED7 RUFY1 CH25H PRKD3 FDX1 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 TIAM2 CYP2E1 FAR2 MTMR3 MTMR8 CGA BDH2 PLA2G3 BDH1 MTMR9 OXCT1 PLA2G5 OXCT2 PLA2G6 HMGCS2 MTMR6 HMGCLL1 MTMR7 AACS HSD11B1 ACAT1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA PTGES3 CYP4F3 NR1D1 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE CYP27B1 TSPO SPHK2 PTGR1 CYP24A1 PTGR2 CYP21A2 CYP2R1 AHRR SAMD8 PIP4P1 ECHS1 SGMS1 SGMS2 UBE2I PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIP5K1C PIAS4 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 INPP5D ABHD4 PIK3CG ABHD3 PIK3R6 INSIG2 PIK3R5 INSIG1 ARF1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 GBA1 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 CSNK2A1 PLA2G12A CERS5 GPX1 CSNK2A2 CERS6 GPX4 FAAH2 TNFRSF21 CERS1 CSNK2B CERS2 PPM1L HSD17B14 TPTE LRP2 CYP3A4 HSD17B11 MMAA MMUT AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 MBOAT1 DDHD2 MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PCCA PITPNB CPNE7 ECI1 PCCB CPNE6 GDE1 ACACB ACSM6 CPNE1 CPNE3 PTGDS MFSD2B ACAD11 SPHK1 ACAD10 MFSD2A SACM1L SLC51A ESRRA SLC51B PISD CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 CDK8 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 MTMR1 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPX2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS CBR1 SMARCD3 PCYT1B PCYT1A STARD3NL PLAAT1 PLAAT3 PLAAT2 CYP7B1 PLAAT5 PLAAT4 AKR1D1 GDPD1 ALOX12B GDPD3 GDPD5 HSD17B7 CYP7A1 ORMDL2 PPP1CC HSD17B1 TXNRD1 ORMDL3 HSD17B2 PIK3CB SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CYP8B1 ETNPPL PLEKHA8 PNPLA3 PTPN13 PNPLA6 VAPB ACAA2 INPPL1 MSMO1 CYP46A1 PLB1 ENPP6 PIK3CA PIK3R3 SBF1 HADH SBF2 PIK3C3 TPTE2 TRIB3 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 THEM4 CHAT PLD4 PLD6 ARNT2 PLD3 NFYA ALDH3B2 NFYB EBP NFYC CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 BMAL1 ACBD6 ACBD4 DGAT2L6 CRLS1 ACSF2 CYP11B2 PI4KA VAC14 PI4K2B PLD2 DEGS1 MTMR10 ALPI MTMR2 DEGS2 MTMR12 PI4KB PIK3C2A ACBD5 TNFAIP8 MTMR4 CYP4A22 MTM1 DBI INPP4A PCTP FIG4 ACOXL INPP4B ABCC3 PLA2G4F PIKFYVE INPP5F ABCC1 PI4K2A PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L ME1 CPT2 POMC MID1IP1 SLC25A20 PPP1CA CPT1B CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT PPP1CB CYP11B1 AKR1C3 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 LDLRAP1 CUBN APOA2 APOA1 PRKACG APOA5 PRKACA PRKACB ANGPTL4 SAR1B MBTPS1 ALB MBTPS2 PLA2G2A SLC27A1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 PRKAA2 PHYH ACOT8 PRKAG2 GNPAT ACOT2 ACOT4 PRKAB2 HACL1 DECR2 HAO2 EPHX2 PPARGC1A AMACR PPARGC1B RAN MAPKAPK2 CROT LBR ABCD1 OCRL BAAT MED16 SLC25A17 MED15 ACOX2 MED17 MED12 EHHADH MED14 MED13 AGPS ACOX3 MED10 TAFAZZIN HSD17B4 MED27 HMGCL MED26 MED23 MED25 MED24 MED20 PPARG CAV1 PPARA SRD5A3 PPARD NUDT7 VAPA CRAT SEC23A HEXB HEXA LTC4S RORA GLB1L3 GLB1L2 GLB1L SEC24B GLB1 SEC24A PLD1 ARSB HADHB HADHA ACADVL CYP17A1 SEC24D SEC24C EP300 MED30 MED31 RXRA INPP5E HDAC3 MOGAT3 MOGAT2 MOGAT1 GPS2 ABHD5 FABP12 RXRB GK3 GK2 LIPE AGMO GPAT2 TBL1X DGAT2 GK NCOA1 ABCA1 DGAT1 FABP9 FABP1 FABP2 FABP3 NR1H2 FABP4 FABP5 NR1H3 GPD2 NCOR2 FABP7 ARNT PNPLA4 PLIN3 NCOR1 PNPLA5 TBL1XR1 LPIN1 FABP6 LPIN2 MGLL SUMO2 LPIN3 PLIN1 PEX11A CD36 NCOA2 NCOA6 NCOA3 CCNC MVD PLIN2 ST6GALNAC5 ST6GALNAC6 PNPLA2 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 CREBBP SP1 NEU1 CHD9 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA TGS1 SREBF1 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGF ERBB2 MEMO1 EGFR RHOA NRG1 DIAPH1 EREG NRG3 NRG4 NRG2 BTC REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins JUP PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 SOX10 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 CDH19 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 SV2C SV2B SV2A VAMP1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 PRKAB2 PRKAA2 ADIPOQ MLXIPL PRKAG2 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression ASAH1 DICER1 TRPM1 PXN SMARCD1 SMARCD2 SMARCD3 SMARCE1 LIG1 GMPR SOX2 AKT2 ATP6V1E1 ATP6V1G1 ATP6V0B ATP6V0E1 DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H TBX2 HINT1 CCND1 ITGA2 SIN3A CDK2 CTNNB1 MET ATP6V1C1 GPR143 TNRC6C MOV10 TFAP2A AGO3 STT3B AGO4 CDH1 AGO1 AGO2 DPF1 TNRC6A TNRC6B DPF2 DPF3 SS18L1 ARID1A ARID1B PPARGC1A PLK1 SS18 SMARCB1 CCNB1 SOX10 SMARCC1 BRCA1 SMARCC2 ACTB ACTL6A GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CCND1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 GSK3B RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 TRMT10C FASTKD2 PRORP MTERF4 ELAC2 TFB1M MRM1 HSD17B10 MRM2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing NFKB2 CTSG RELA IL18 IL1A CASP1 NFKB1 IL1B GSDMD PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B PIWIL2 POLR2C TDRKH POLR2D HSP90AA1 PIWIL1 POLR2E HENMT1 POLR2F ASZ1 POLR2G MAEL POLR2H MOV10L1 POLR2I POLR2J MYBL1 POLR2K TDRD9 POLR2L TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 PIWIL4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation HDAC6 HSBP1 PTGES3 EEF1A1 HSF1 YWHAE RPA3 HSP90AA1 VCP RPA1 HSP90AB1 RPA2 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 OGG1 NEIL1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 CTNNB1 AXIN2 TCF7L2 TCF7L1 MYC LEF1 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle FURIN CCR5 CXCR4 CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 TBP NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 HMGA1 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 LIG1 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 XRCC6 CHMP7 XRCC4 XRCC5 LIG4 RANGAP1 TAF7L FEN1 ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events KNG1 RASGRP2 RASGRP1 NPFFR2 OXTR NPFFR1 RGSL1 GRPR AVPR1B CYSLTR1 EDNRA EDNRB PROK2 PROK1 AVPR1A UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT NTSR1 NTSR2 ITPR1 GPR17 ITPR2 NMB ITPR3 XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN TRPC7 BRS3 GPRC6A GPR132 TRPC6 CCKAR GNRHR TRPC3 FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R MCHR1 P2RY10 P2RY11 LPAR1 GCGR LPAR2 GPR4 LPAR3 GCG LPAR5 MT-RNR2 F2RL1 F2RL2 CHRM3 F2RL3 CHRM1 GPR68 GPR65 CHRM5 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 TRIO MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 PRKCQ PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 RGS16 ADRA1D P2RY6 HTR2A P2RY2 ADRA1B P2RY1 RGS21 ADRA1A CCK HRH1 HCRTR2 HCRTR1 KISS1 HBEGF MAPK7 KALRN GPR143 PTGFR PTGER1 TBXA2R AGT PRKCD PRKCA BTK GRK2 PRKCE GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 FFAR1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARHGEF25 EGFR HRAS PIK3R3 PIK3CA SOS1 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 MGLL DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ DAGLB DGKK DGKI DGKH AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL1A1 COL25A1 COL1A2 COL22A1 COL23A1 COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL20A1 COL4A6 COL6A3 COL21A1 COL9A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COL3A1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 DCP2 MAPK11 PARN EXOSC7 KHSRP EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 FGF20 FGF16 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions OCLN RUNX1 TJP1 CBFB CLDN5 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex PCNA UBA52 WDR48 RAD18 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2B POLE2 POLE3 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACSM6 ECHS1 ACSM3 ACADS HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) STPG4 UHRF1 H2BC9 METTL23 H2AZ2 H4C9 DPPA3 H2BC8 H2BC5 H2BC3 H2BC1 AICDA H2AC20 TET3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KDM5B H2BC12 KDM5A H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 KDM6B H3C15 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6C MOV10 AGO3 AGO4 CD274 AGO1 AGO2 TNRC6A TNRC6B RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G POLR3H POLR2K POLR3K POLR2L POLR1C POLR1D MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation MET HGF SPINT1 HPN SPINT2 HGFAC PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade PIK3R4 PIK3R2 PIK3R1 FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis PARP1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum POFUT1 NOTCH2 NOTCH3 NOTCH1 POGLUT1 NOTCH4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events AKT2 PDE3B POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels GNG13 GNB2 KCNJ8 GNB1 KCNJ11 ABCC8 ABCC9 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNMA1 GNG3 GNG2 GNG5 GNG4 GNG7 KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK1 KCNN2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ2 KCNJ2 KCNQ3 KCNJ3 KCNQ4 KCNJ4 KCNQ5 KCNV1 KCNV2 GABBR2 KCNN1 KCNJ5 KCNN3 KCNN4 KCNJ6 KCNF1 GABBR1 KCNC1 KCNJ10 KCNK9 KCNC2 KCNJ12 KCNC3 KCNJ9 KCNC4 KCND1 KCND2 KCND3 KCNJ15 KCNAB1 KCNJ16 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 KCNK4 HCN1 GNG10 GNG12 GNG11 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction SORBS3 MYL5 MYL7 ITGA1 PXN ITGB5 GUCY1B2 GUCY1B1 TPM4 TPM3 GUCY1A2 GUCY1A1 PDE5A ANXA2 TLN1 VCL TRIM72 DYSF PAK1 LMOD1 MYL6B MYL12B CACNA1H MYL6 MYL12A MYLK CACNA1G MYH11 CACNA1I MYL9 ALDH2 CALD1 PAK2 ANXA6 MYL10 CAV3 TPM2 MYL11 CALM1 TPM1 ANXA1 SORBS1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C OXA1L KGD4 UCP1 NDUFAB1 ACAT1 MT-CO1 BCS1L COX19 COX17 ATP5MC1 SCO2 MT-CO2 MT-CO3 CYC1 CS VDAC1 ACO2 UBA52 HSCB HSPA9 TIMM21 UBB UBC RPS27A SLC25A12 FXN SLC25A13 NDUFB8 ATP5F1A SIRT3 ATP5F1B IDH3G CYCS MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 PC CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D LETM1 MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SLC25A4 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ATP5MK COX11 ATP5MJ COX14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5MF ATP5ME COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 COXFA4 NDUFA6 FAHD1 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 PDK4 NDUFS3 WDR26 PDHB GOT2 RMND5B LDHA MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 ECSIT PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 COX7B GPT COX7C COX8A COX8C DLD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A IK SNRPN PRP4K WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response XIAP CARD8 CYCS UACA MAPK1 AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells FGF10 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K4 IKBKB UBC RPS27A FBXW11 NFKB1 TNIP2 UBA52 BTRC CHUK SKP1 MAP2K1 MAP3K8 IKBKG CUL1 UBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins MUC13 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 MUC1 POMT2 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 POMT1 MUC4 MUC6 POMGNT1 MUC16 GALNT3 B4GAT1 MUC17 C1GALT1 MUC19 DAG1 SSPOP MUC5B LARGE1 MUC20 MUC21 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 SH3GL1 UBA52 STAM STAM2 MET HGS UBB SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 DPH7 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEL1L RAD23B PRKCSH UBA52 RNF185 GANAB PDIA3 VCP EDEM2 MOGS UBB DERL1 UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 UBXN1 PSMC1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects PNP PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway CLTC CLTB FZD2 WNT5B FZD5 FZD7 WNT5A ROR1 FZD4 CLTA ROR2 AP2A1 PRICKLE1 FZD6 RAC2 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 RHOA AP2S1 SMURF2 SMURF1 AP2B1 PSMD8 PSMD6 PSMD7 PSMD2 ARRB2 PSMD3 SCRIB VANGL2 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DAAM1 PFN1 PARD6A ADRM1 PSMC5 PSMC6 RAC1 PRKCB SEM1 PSMC3 DVL1 PSMC4 DVL2 WNT4 PSMC1 DVL3 PSMC2 PRKCG WNT11 FZD3 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOT2 ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B KIF5A NCKIPSD RAP1GDS1 KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 VHL AR CFTR RHOT1 BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 LRRC41 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 CCNE1 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 PLIN3 NCOA2 PTK2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT5 GGT7 GGT6 DPEP2 GGT3P DPEP1 GGT1 ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CYP3A4 CYP1A2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R3B E2F1 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B POLA2 PPP2R1A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin F8 F2 VWF INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 ISL1 GIP DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C GATA4 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO SAE1 SENP5 SUMO3 SENP1 SUMO2 SENP2 UBE2I SUMO1 RWDD3 UBA2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HNRNPC BMI1 SUMO2 RING1 HNRNPK UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 NOP58 CBX2 PHC3 AAAS NUP160 NUP214 POM121C NUP42 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 KLB FGF16 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 ECHS1 ACAT1 MCCC1 PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A CSK RAF1 JAK2 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 IGF2 CTSG IGF1 TF CALU KLK3 KLK2 SERPINA1 MBTPS1 KLK13 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN PLG ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 LAMB2 PDIA6 PAPPA MXRA8 SPARCL1 FN1 IGFALS LAMB1 SCG2 KLK1 LAMC1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 GZMH NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC F2 GAS6 APLP2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling IFNA2 IFNA8 TYK2 IFNA13 IFNA14 IFNA16 STAT2 IFNA17 SOCS3 PTPN6 IFNAR1 IFNA10 IFNA21 IFNB1 JAK1 IFNA5 IFNA4 PTPN1 SOCS1 IFNA7 USP18 IFNA6 PTPN11 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CB RAPGEF1 CRK PIK3CD LYN PIK3R2 CBL PIK3R1 YES1 HCK BLNK SYK FYN PIK3R3 CRKL PIK3CA VAV1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling DPYSL3 FES PLXNA2 PLXNA3 CDK5 FYN PLXNA4 NRP1 CDK5R1 CRMP1 GSK3B DPYSL4 PLXNA1 DPYSL5 SEMA3A DPYSL2 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade SOS1 SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS FGF20 THEM4 MAPK1 FGF23 FGF22 KLB MAPK3 FLT3 IRS1 INSR PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade SERPING1 C3 CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PROS1 F2 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PFKFB1 PRKACA PRKACB MLXIPL ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells UPK1A EPCAM FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation FGF23 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism PNPLA7 PNPLA6 GDPD1 GDPD3 GDPD5 ENPP6 GDE1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3CA PIK3R3 PIK3R5 ICOSLG FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription CITED2 GCK FBXO32 G6PC1 CDKN1A INS HDAC1 NPY NFYA CCNG2 SIN3A NFYB NFYC BCL2L11 PLXNA4 FASLG PCK1 NR3C1 FOXO4 ATXN3 BTG1 DDIT3 TRIM63 STK11 SMAD2 SMAD4 AGRP SMAD3 BCL6 HDAC2 YWHAB TXNIP PINK1 AKT1 YWHAQ YWHAG RBL2 YWHAZ SFN PPARGC1A CAT ABCA6 RETN CDKN1B POMC SOD2 KLF4 CREBBP BBC3 FOXG1 KAT2B FOXO6 PCBP4 FOXO1 EP300 AKT2 IGFBP1 SIRT1 MSTN SIRT3 FOXO3 TXN SREBF1 GADD45A CAV1 AKT3 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex BICRAL ACTL6A BICRA BRD9 SS18 SMARCD1 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SS18L1 ACTB TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation SNAP25 RAB3A SLC32A1 STX1A SYT1 SLC6A13 HSPA8 ABAT SLC6A1 VAMP2 CPLX1 GAD1 RIMS1 GAD2 ALDH5A1 DNAJC5 SLC6A11 SLC6A12 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase OCLN DSG1 DSG3 PLEC ADD1 ROCK1 H1-1 H1-0 H1-3 LMNB1 CTNNB1 TJP1 H1-2 H1-5 H1-4 VIM CLSPN CDH1 SATB1 CASP6 PRKCD APC KPNA1 BIRC2 SPTAN1 DFFB DFFA DBNL ACIN1 KPNB1 GAS2 MAPT BCAP31 GSN TJP2 FNTA DSG2 PKP1 BMX STK24 STK26 HMGB2 HMGB1 PRKCQ CASP8 PAK2 PTK2 CASP7 DNM1L DSP CASP3 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants ALK DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair NEIL3 NEIL1 PMS2 MLH1 MSH2 MSH3 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 MSH6 RMI2 RFC3 RFC4 RMI1 OGG1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A NTHL1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling RELA MAP3K7 IL1RL1 IL33 CTSG MAP2K6 IL1RL2 IL36A IL36B IL1R1 IL36G IL36RN IL1F10 SMAD3 TBK1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 GSDMD USP14 BTRC IL18 NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 PTPN13 HMGB1 CASP8 MAP2K1 UBE2N STAT3 NFKB1 MAPK8 CHUK PTPN11 IKBKB SQSTM1 MYD88 SIGIRR IRAK3 ALOX5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 CASP1 PSMD1 PSMA5 PSMA6 PSMA3 PTPN4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL18RAP IL1R2 PSMD13 IL4 NFKB2 TOLLIP PSMA7 PTPN20 PTPN23 PSMB6 IL18BP IL13 PSMB7 IL1RAPL1 PSMB4 MAP3K3 NKIRAS1 PTPN18 NKIRAS2 PSMB5 IL37 MAP3K8 IKBKG PTPN12 UBB PTPN14 IKBIP RIPK2 PSMB2 PTPN9 MAP2K4 PSMB3 PTPN7 IRAK4 PTPN5 UBC IL18R1 PSMB1 PTPN2 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 PTPN6 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 ELAC2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG ABHD6 ABHD12 DAGLB MGLL DAGLA MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR3 CTSS CNPY3 TLR8 TLR7 CTSB CTSV CTSL LGMN CTSK HSP90B1 TLR9 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 HBS1L EXOSC7 NT5C3B EXOSC6 SKIC2 SKIC3 DCPS EXOSC5 EXOSC4 DIS3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 VCP SHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA PARP1 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 RFC2 RFC1 PARP2 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 PARG APEX1 ADPRS PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria PAH NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways NUP85 TPR KPNA7 NUP62 KPNA4 KPNA5 NUP88 GBP1 NUP43 KPNA3 RAE1 PABPN1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 EIF2AK2 ISG15 NUP37 KPNB1 MLKL KPNA2 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 GP1BA H2AC20 SETD1B SETD1A SIN3A ASH2L TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B NR4A3 MYL9 SIN3B DPY30 WDR5 GATA1 THBS1 RBBP5 PF4 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KAT2B KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 ZFPM1 PRKCQ H2BC11 KMT2A CBFB ITGA2B H3C15 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA CYP26B1 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation AGPAT2 ARPC5 GM2A ACTR2 APEH ARSA FGR ASAH1 PECAM1 RAB9B PSAP MGST1 MME GLA P2RX1 CAT IST1 CD14 GSDMD RETN SPTAN1 DBNL FUCA2 KPNB1 GSN TICAM2 DNAJC3 PKP1 SDCBP RAC1 CST3 HMGB1 DSP DSG1 C3AR1 MAGT1 LTA4H NCSTN ADAM10 PSEN1 CDK13 GOLGA7 C5AR1 ACTR10 HSPA1B DDOST LPCAT1 ALOX5 CD59 CD55 HPSE SNAP25 RAB3A DNAJC5 KRT1 CNN2 TOLLIP ANXA2 MIF PPIA CSNK2B CTSB CDA FRMPD3 RAB14 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 RNASE2 UNC13D FLG2 PADI2 FPR1 CPNE1 GNS CPNE3 PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 VCP FUCA1 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 HMOX2 SIGLEC5 GHDC TMEM179B RAB3D HP EPX SLC44A2 PYCARD RAB44 CR1 GLIPR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B RAB5C STK10 BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 FCAR ALAD FCGR3B ORMDL3 PGM2 ACP3 TCIRG1 SNAP29 PGM1 RNASET2 DYNC1LI1 TNFRSF1B PKM PTGES2 TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC CTSD TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 FAF2 PTPRN2 SIGLEC14 ATP6V0C STK11IP SURF4 PRG2 NBEAL2 PRG3 RHOG DYNLL1 DERA BST2 RHOF BST1 NRAS VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ MAPK1 ACTR1B CTSH CD33 CTSC CD53 ATP6V1D MANBA ALDH3B1 FCER1G GAA NME2 ATP6V0A1 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CD47 DEGS1 CD44 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 CKAP4 OSTF1 CD93 LRRC7 CD300A IRAG2 ATAD3B OSCAR TYROBP DOCK2 DOK3 COPB1 ADGRG3 MOSPD2 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 NAPRT ADGRE3 HGSNAT DYNLT1 ATP6AP2 ARMC8 PLAUR MMP8 MMP9 CHI3L1 PDXK BIN2 CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 RAB27A CEACAM1 LAMP2 PPIE ARG1 AP2A2 A1BG SLC15A4 RAP1B RAP1A CTSG NPC2 PPBP PRSS3 PGLYRP1 PRSS2 CAMP SERPINA3 ORM1 FPR2 SLC11A1 SERPINA1 RNASE3 ORM2 TRPM2 BPI QSOX1 PRTN3 S100A9 CAP1 S100A8 AHSG LTF TLR2 S100A7 CD63 PTAFR DEFA1B ELANE DEFA4 LYZ CAPN1 LCN2 AMPD3 APRT PNP IMPDH1 IMPDH2 EEF1A1 ACLY HLA-H SLC27A2 HLA-B HLA-C HSP90AB1 ACAA1 ATG7 CAB39 B4GALT1 CTSS VAMP8 PSMD6 PSMD7 HUWE1 PSMD2 PSMD3 LAMTOR2 LAMTOR1 PSMD1 LAMTOR3 CYFIP1 IDH1 PRKCD PSMA5 SNAP23 PSMA2 PSMD12 PSMD11 STBD1 PSMD14 CEP290 PSMD13 KCNAB2 TUBB PSMB7 CYBB CYBA PSMB1 RAB7A HSPA8 MAPK14 UBR4 PSMC3 PSMC2 HSPA1A NCKAP1L APAF1 CFD C3 ATP8A1 VAPA ATP11B CCT2 ATP11A ROCK1 ATP8B4 B2M STING1 AP1M1 HEXB GLB1 ARHGAP45 IQGAP1 ANO6 PLD1 GUSB IQGAP2 ARSB HSP90AA1 FRK JUP ARHGAP9 STOM ITGAV FTH1 FTL NDUFC2 XRCC6 XRCC5 NFKB1 ITGAX CHRNB4 ITGAL DGAT1 FABP5 GPI CD36 HK3 PGAM1 LGALS3 CFP ALDOC ALDOA PFKL NEU1 PTPN6 CTSA S100A12 EEF2 MLEC TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP PML UBC PTEN RPS27A NEDD4 USP7 UBA52 UBB MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins MET TNS4 TNS3 HGF ITGB1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling HBEGF EGF ERBB2 PIK3R1 EGFR NRG1 GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion PDS5B SMC1A SMC3 PDS5A WAPL STAG1 STAG2 ESCO1 RAD21 ESCO2 CDCA5 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation UGT2B7 UGT1A3 SLC35D1 SLC35D2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT1A9 UGT2B17 UGDH UGT2B4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CX3CR1 CCL3L3 CXCR5 CCR5 CXCR6 CXCR4 CCL7 CCR6 CCL5 CXCR3 PPBP CCL4 CCL3 CCL2 CCL1 CCL19 CCR2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 CXCL10 CXCR1 CXCL11 CXCL12 CXCR2 ACKR4 ACKR3 ACKR2 XCR1 CCL28 CCL27 CXCL1 PF4 XCL2 XCL1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism SERINC4 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 LBP CD14 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse LYN NGEF YES1 RHOA ROCK1 MYL12B FYN ROCK2 MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2S1 AP2A1 AP1G1 AP1S2 AP1S1 AP2A2 AP1S3 B2M AP1M2 AP2B1 AP1M1 AP1B1 HLA-A AP2M1 ARF1 CD8B PACS1 ATP6V1H LCK CD28 CD4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events NTRK1 KIDINS220 RAPGEF1 CRK NGF YWHAB MAPK1 RAP1A FRS2 MAP2K1 MAP2K2 CRKL MAPK3 BRAF NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR FLT1 NRP2 KDR NRP1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer PRF1 ICOS STAT5A IL10RA ZC3HC1 STAT3 CCNB1 HDAC1 NPM1 GZMB RB1 MAPK1 CEBPB MAPK3 DNMT1 FOXM1 TNRC6C MOV10 AGO3 AGO4 JUNB PTPN6 AGO1 AGO2 RPS6 IRF4 BCL2A1 SKP1 RBX1 TWIST1 ZAP70 CUL1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX4 ALOX12B ALOX15 ALOX12 GPX2 GPX1 ALOXE3 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) CYP51A1 EBP LBR DHCR7 MSMO1 NSDHL HSD17B7 TM7SF2 SC5D DHCR24 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules VASP ITK TRAC CD3G CD3E CD3D PLCG1 TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 EVL HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 NCK1 WAS PAK1 PAK3 LCK PLCG2 PAK2 ZAP70 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CACNA1D CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) RPS6KA1 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 SGK1 MAPK1 NAB1 NAB2 LYL1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 PPP2CA EGR3 PPP2CB JUND EGR4 FOSL1 ID2 ID1 MEF2C CDK5 ID4 FOSB ID3 CDK5R2 TCF12 CHD4 MAPKAPK2 REST ATF1 PPP2R1B PPP2R1A SH3GL3 VGF EP300 JUNB MAPK14 MAPK11 MEF2D FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs NEDD4L STUB1 ITGB8 ITGB5 FURIN PMEPA1 CBL BAMBI STRAP UBA52 TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 PPP1CA USP15 ITGA8 PPP1R15A PPP1CB PPP1CC TGFB2 UBB TGFB3 UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD4 SMAD3 SMURF2 SMAD7 SMURF1 NEDD8 TGFBR3 FKBP1A XPO1 LTBP4 ITGB3 ITGB1 LTBP3 LTBP1 ITGAV DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG1 UBC RPS27A RNF41 ERBB2 USP8 AKT1 AKT2 UBA52 NRG2 UBB AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors OXTR OXT AVPR1B AVP AVPR2 AVPR1A EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP8B1 TBXAS1 CYP4F3 CYP4A22 CYP4B1 CYP4F8 CYP4F2 CYP4A11 PTGIS CYP4F12 CYP4F22 CYP4F11 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment IKBKB RIPK1 UBC UBE2D1 TICAM1 RPS27A TLR3 UBE2V1 TRAF6 UBA52 BIRC2 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense SFN FNTA GBP1 FURIN GBP5 PIM1 PGGT1B GBP2 FNTB GBP4 GBP3 CASP1 ACTG1 ACTB PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 HEXB NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 RRP8 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 SUV39H1 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 SIRT1 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes PCBP4 TP53 CDKN1A ZNF385A RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 TEAD3 TEAD4 CCN2 RUNX3 WWTR1 TEAD1 TEAD2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity UBC PTPN2 SH3KBP1 RPS27A SH3GL3 EPS15 USP8 CBL SH3GL2 SH3GL1 UBA52 STAM PTPRJ LRIG1 STAM2 MET HGS HGF PTPN1 UBB NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 UBC RPS27A CBL UBA52 PTPRJ SLA ABL2 CSK SLA2 SOCS2 SOCS6 FLT3LG SH2B3 FLT3 UBB FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER CCNH RAD23A RAD23B PARP1 CETN2 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A DDB2 PIAS3 SUMO3 SUMO2 PARP2 USP45 UBE2I RPA1 PIAS1 RNF111 CHD1L SUMO1 RPA2 DDB1 UBE2V2 XPA XPC CUL4A RPA3 RBX1 ERCC4 ERCC1 UBE2N ERCC5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TICAM2 TICAM1 RIPK3 CASP8 LY96 FADD CD14 TLR4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 SLBP CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 PTPN12 NRG2 BTC TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation GP5 SERPINA5 GP9 SERPING1 A2M KLKB1 PRCP GP1BA KNG1 SERPINC1 C1QBP F9 PROC F10 SERPIND1 PROS1 F8 F2 VWF SERPINE2 GP1BB F12 F11 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions BAG4 FGFR1 ERLIN2 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling EPHB6 EFNB2 NCK2 EFNB1 ARHGEF7 EFNB3 EPHB2 EPHB1 SDCBP EPHB4 EPHB3 PAK1 PAK3 RAC1 FYN MYL12A GIT1 PAK2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation RIPK1 TICAM2 TRAF2 TNFRSF10B TICAM1 TNFSF10 TNFRSF10A LY96 FADD CD14 TRADD FAS FASLG CASP8 TLR4 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 ERBIN PRKCA SOS1 PTK6 STUB1 HBEGF SHC1 HSP90AA1 ERBB2 EGF USP8 PIK3R1 EGFR MEMO1 CDC37 NRAS PLCG1 UBA52 MATK RHOA PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 SRC YES1 HRAS NRG1 FYN GAB1 PRKCE DIAPH1 GRB7 AKT1 EREG NRG3 PIK3CA NRG4 NRG2 BTC AKT3 PRKCD DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN IL10 YES1 HCK SYK AHCYL1 FYN FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen GP5 GP9 ITGA1 LYN GP1BA GP6 ITGA10 FYN ITGA2 ADAMTS13 FCER1G VWF ITGB1 GP1BB PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs PAPOLA SYMPK NCBP1 CSTF2T NCBP2 CLP1 FIP1L1 PABPN1 CPSF4 CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 PCF11 CPSF2 CSTF2 WDR33 CSTF1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors NR1H2 NR5A1 RXRA PIAS4 NR2C1 PIAS3 ESR1 SUMO3 SUMO2 UBE2I VDR PIAS1 HDAC4 NR4A2 SUMO1 NR3C2 THRB RORA RARA NR3C1 PGR PPARG AR PPARA DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K POLR2L GTF2H1 CAVIN1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 TTF1 ERCC3 ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations DAG1 POMT2 POMT1 POMGNT1 MGAT5B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation NFATC2 AHCYL1 NFATC3 PPP3CA PPP3CB NFATC1 ITPR1 ITPR2 ITPR3 PPP3R1 CALM1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 CYSLTR1 CYSLTR2 DPEP1 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PTK6 CDKN1A CDC25B CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 FZR1 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT4 WNT3A LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WIF1 SOST TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand LBP CD36 LY96 TLR1 CD14 GSDMD GSDME S100A9 APOB TLR6 S100A8 TLR2 TLR7 FGB HMGB1 S100A1 FGA FGG TLR4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport ABCB6 ABCB4 SEL1L KCNJ11 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 VCP ABCC2 ABCG8 ABCC6 EIF2S2 EIF2S1 EIF2S3 ABCG5 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 ABCA3 ABCC3 ABCC1 ABCG1 ABCD3 PSMD8 PSMD6 ABCC4 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 ABCD2 ABCA6 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 ABCC5 PEX3 UBC ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 SEM1 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 ABCA12 PEX19 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 GFPT1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 CILP PIK3CA TLR9 PIK3C3 TRIB3 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly SERPINB1 CASP4 CALM3 CALM2 CALM1 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand TLR7 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin FDX1 FDX2 FDXR HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM5D PHF8 UTY KDM4B H4C9 KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 KDM7A KDM3A KDM1A KDM1B KDM4A KDM4C H3C8 KDM5B KDM5A KDM6A PHF2 KDM6B KDM5C KDM3B H3C15 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 FZR1 PLK1 FBXO5 CCNB1 CDC20 CDK1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle CLTC IQGAP1 SH3RF1 VANGL1 ARHGEF7 PIK3R1 RHOV MAP3K11 SPTAN1 MYO9A TPM4 GIT1 TPM3 TXNL1 WASL ARHGAP12 CDC42 DEPDC1B ZNF512B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 PARD6B PAK6 PAK1 CCP110 CEP97 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle DSG1 VANGL1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 ROCK1 TMOD3 TXNL1 PKP4 DDX4 RASAL2 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B EPHA2 WDR6 DST UBXN11 DLG5 PICALM ARHGAP21 TNFAIP1 SEMA4F PTPN13 RND3 NISCH KTN1 CKB CKAP4 PLEKHG5 KCTD13 SCRIB VANGL2 FLOT2 DSP CAV1 CCDC88A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 GPAM MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab ERBIN HSP90AA1 ERBB2 CDC37 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP3 CHMP6 CHMP7 TUBB8 IST1 TUBA8 TUBA1C LEMD2 TUBA1B TUBB8B TUBA1A TUBB2B TUBB2A SPAST CC2D1B TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D CHMP4C TUBA3C CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A TUBB4B TUBB4A SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 CSF1R SHC1 LYN STAT3 CBL INPP5D PIK3R1 IL34 UBA52 GAB3 GRAP2 STAT1 KRAS UBB PTPN11 PIK3CB UBC RPS27A PIK3CD THOC5 SRC YES1 HCK FYN INPPL1 PLCG2 GAB2 PIK3CA CSF1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 BBS2 BBS1 CCT2 CCT8 RAB3IP CCT5 BBIP1 BBS9 CCT4 BBS7 CCT3 TTC8 BBS5 BBS4 MKKS SMO TCP1 SSTR3 LZTFL1 BBS10 BBS12 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACSM6 HADHB MECR ACADL HADHA ACADVL ECHS1 ACADM ACSM3 ACADS HADH SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 HDAC1 NEURL1B DNER HES5 TLE4 APH1A TLE2 HDAC3 DLL4 MIB2 ITCH PSENEN TLE1 DTX1 NCSTN MIB1 DTX2 APH1B HEYL PSEN2 DLK1 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 DTX4 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 ARRB1 RBX1 ARRB2 HIF1A HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 NUMB HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NBEA NOTCH1 CUL1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib ERBIN HSP90AA1 ERBB2 CDC37 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FPGT FCSK GFUS FUOM MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) MYD88 TLR5 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5E NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation FGF19 FGF18 FGFR4 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 KLB FGF20 FGF16 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG1 HRAS SOS1 HBEGF SHC1 NRAS NRG3 EREG NRG4 BTC NRG2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CDKN1A CDKN1B ARID3A E2F1 CDK2 E2F7 E2F8 CCNA2 TP53 CCNA1 CCNE2 CCNE1 ZNF385A CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling RELA NFATC1 MAP3K7 NFKB1 UBA3 UBE2M CDC34 NFATC2 CHUK IKBKB CARD11 MALT1 ITPR1 RELB ITPR2 CLEC7A ITPR3 CARD9 NFKBIA MAP3K14 TAB1 UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PLCG2 PSMD3 PSMD1 CALM1 PYCARD PRKCD PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 TRAF6 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 NFKB2 PSMB6 PSMB7 IL1B PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB TAB3 SKP1 PDPK1 TAB2 CASP8 PPP3R1 UBE2N CUL1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UXS1 UGDH UGP2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events GNAQ ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 GNAT3 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 CAMK2A GNAI3 GNAI1 GNAI2 CALM1 CAMK2G PRKCD PRKCA PLCB4 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 NBEA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle ERBIN ARHGAP26 ARHGEF3 VANGL1 ARHGEF1 ARHGAP32 ARHGEF2 PIK3R2 ARHGEF5 PIK3R1 RHOB ROCK1 CAVIN1 ROCK2 MYO9A ABR RTKN ECT2 ARHGEF28 MCF2 NET1 RHPN2 ARHGDIG SOWAHC STARD8 CIT ARHGEF25 PKN3 TFRC IQGAP3 SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 STOM MCF2L RACGAP1 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis FUT2 FUT1 ABO NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAP2K1 MAP2K2 MAPK3 BRAF DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type MMAB SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors SCARF1 APOB CALR HSP90AA1 HSPH1 HYOU1 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways HBEGF GBP1 FURIN HSP90AB1 HBB ATP6V1H MAPK1 STAM2 CTSG CTNNB1 MET RNF213 MAPK3 STX1A B2M CDH1 MRC1 SRC GBP2 UBE2D2 GBP6 GBP4 HBA2 STX1B NOS2 CBLL1 LTF TLR2 GUCY2C SYT2 NHERF4 GSK3A CALM1 ENO1 SNAP25 SH3KBP1 TRIM27 HSP90AA1 KPNA1 SYT1 CD9 CBL CTNND1 UBA52 STAM DUSP16 VPS33B CORO1A PGK1 HGS RAB5A KPNB1 SV2C SV2B SV2A VAMP1 UBB TXNRD1 MAP2K4 UBC RAB7A RPS27A SH3GL3 UPK1A EPCAM EPS15 SH3GL2 SH3GL1 SFPQ VAMP2 MAP2K7 EEF2 CASP4 MAP2K1 MAP2K2 CALM3 CALM2 PDCD6IP MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB RABGGTA NDRG1 BCL6 PERP TP53I3 BIRC5 TP63 TP73 PPP1R13B TP53 TP53BP2 BCL2L14 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE MTR MTRR SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 PI4KA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K7 FURIN MAP2K1 MAP2K2 CALM1 PDCD6IP CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle PCNA NPM1 YWHAE EML4 YWHAQ CDCA5 MYBL2 NCAPG YWHAG ARPP19 ZNF385A NCAPH YWHAH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A UBE2V2 PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 UBE2N CHMP3 CHMP6 CHMP7 PLK3 CDC7 HSPA2 FBXL18 FBXL7 PHF20 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH PIAS4 POLR2A POLR2B POLR2C POLR2D BRCC3 LYN POLR2E POLR2F POLR2G POLR2H CDKN2B POLR2I POLR2J POLR2K POLR2L BABAM1 CDK7 BABAM2 MNAT1 UIMC1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 RUVBL1 ABL1 WRAP53 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E CLSPN NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 MDM2 MDM4 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 ABRAXAS1 NUP37 ERCC6L RBBP7 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 CHEK2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MLH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 JAK2 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 PPP1CB CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 HJURP RFC5 RMI2 PPP2R2A RFC3 PPME1 GTSE1 RFC4 RMI1 BORA TERT FKBPL RFC2 FBXW11 OPTN TOP3A OBI1 HMMR RPA1 HUS1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B RAD50 TICRR MCM7 RAD51 MCM8 RAD51C GMNN RPA3 RAD17 SKP1 RAD1 CCNA2 ATM CCNA1 MCM3 DNA2 RAD9B MCM4 RHNO1 MCM5 MCM6 ATR RAD9A MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 FKBP6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B HERC2 PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MDC1 MYC YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 PIF1 FIGNL1 GAR1 CTC1 KMT5A TEX12 TEX15 RNF168 NSD2 CENPW CENPX RUVBL2 OIP5 MSH4 MSH5 HSP90AA1 NHP2 ANKRD28 NOP10 SYCP2 CDC25C SYCP1 CDKN1C SYNE2 RB1 SYNE1 CDKN1B PPP6C PPP6R3 CCND3 SMC1B FZR1 MND1 CCND2 E2F1 REC8 E2F2 SYCP3 E2F3 RTEL1 SKP2 CHTF8 DAXX TP53BP1 ATRX STAG3 CDK6 RSF1 TFDP1 DMC1 PSMC3IP CCNE2 TFDP2 MLH3 CDK4 MIS18A NEK11 CCNE1 H2AX PRDM9 DSCC1 SHQ1 CPAP LIG1 DKC1 MAX H2AB1 SYCE3 H2AC19 SYCE2 POLD3 COP1 H2BC26 POLD4 H2AC14 SYCE1 POLD1 H2BC12L SPO11 POLD2 RCC1 CHTF18 H2BC21 SUN2 EP300 SUN1 RNF8 H3-3B STN1 H3C8 TEN1 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 SMARCA5 GSK3B CSNK1A1 PHLDA1 PCBP4 AKT3 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP ZNF141 HDAC1 ZNF382 H2AC20 ZNF547 ZNF418 ZNF224 MBD3 ZNF354A ZNF136 ZNF649 GATAD2B GATAD2A CHD3 SUMO2 UBE2I ZNF778 HDAC2 ZNF454 ZNF28 CBX5 CHD4 ZNF273 SETDB1 ZNF816 ZNF519 ZNF610 ZNF264 ZNF680 TRIM28 MTA2 ZNF30 ZNF257 RBBP4 MTA1 ZNF33A MTA3 RBBP7 ZNF331 H2AX ZNF93 H2AB1 H2AC19 H2BC26 ZNF708 H2AC14 H2BC12L H2BC21 ZNF324 ZNF534 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ZNF320 H2BC17 H2BC12 H2BC13 ZNF669 ZNF765 H2BC14 H2AJ H2BC15 ZNF317 H2BC11 ZNF425 H3C15 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism TCN2 CD320 MCCC2 BTD ACACA PC PCCA HLCS CUBN CBLIF MMAB MCCC1 AMN PCCB MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 PABPN1 EIF4E PAIP1 EIF4B EIF4A3 PABPC1 DIS3L2 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH PECR SLC25A17 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A6 SLC12A3 SLC12A1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 SNU13 DCAF13 NOP14 UTP6 UTP4 KRR1 UTP3 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP2 TRMT112 NOP56 NOP58 GAR1 NHP2 NOP10 RPS14 DKC1 RPS2 RPS9 RPS7 RPS6 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FURIN H2BC1 INS H2AC20 APH1A PSENEN APOA1 NCSTN APOA4 APH1B HSPG2 ADAM10 APOE NPPA SIAH1 PRL CALB1 NAT8B BACE1 APCS TSPAN33 B2M GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI LTF ITM2B UBA52 SIAH2 LYZ FGA CALCA H2AX UBB GSN SEMG1 H2AB1 UBC H2AC19 IAPP H2BC26 H2AC14 RPS27A H2BC12L H2BC21 PRKN TTR H3-3B H3C8 H2AC8 MFGE8 H2AC6 H2AC7 TSPAN14 H2BC17 APP H2BC12 H2BC13 H2BC14 CST3 SAA1 H2BC15 USP9X H2BC11 UBE2L6 H3C15 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB NBEA CALM1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation RELA MAP3K7 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 CARD11 IGKV2D-28 MALT1 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 TRPC1 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK IGLC1 BTRC IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PRKCB HRAS PPP3CA PPP3CB PPP3R1 VAV1 SOS1 NFATC1 PIK3R1 NFKB1 NRAS NFATC2 CHUK CD19 IKBKB FKBP1A PSMD8 PSMD6 PSMD7 DAPP1 RASGRP3 PSMD2 REL NFKBIE PSMD3 CD22 PIK3AP1 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD FBXW11 PTPN6 ADRM1 PPIA PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation IFNA2 IFNA8 TRAF2 IFNA13 IFNA14 IFNA16 IFNA17 TRAF6 IFNA10 IFNA21 IFNB1 IFIH1 TRIM4 CREBBP TBK1 EP300 IRF3 MAVS RNF135 RIGI TRIM25 IKBKE IRF7 IFNA5 TANK SIKE1 IFNA4 IFNA7 IFNA6 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t PGM1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis HSD3B2 HSD3B1 CGA LHB CYP21A2 CYP11B2 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 HHAT VCP IHH SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 DTX4 TBK1 NFKB1 IRF3 NFKBIA NLRP4 DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling IL21R LGALS9 SOS1 HAVCR2 IL15RA PTK2B STAT5A STAT5B IL15 SHC1 IL5 STAT3 IL3RA PIK3R2 INPP5D IL2RB SOS2 PIK3R1 IL9 GRB2 IL9R JAK3 STAT4 JAK2 JAK1 IL2RG STAT1 CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 SYK LCK INPPL1 GAB2 PIK3R3 PIK3CA IL21 IL2RA IL5RA CSF2RB CSF2RA METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins VKORC1L1 UBIAD1 LRP1 RETSAT APOA2 APOM APOA1 TTPA BCO2 APOA4 BCO1 HSPG2 VKORC1 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation LCK AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 ARF1 CD4 ATP6V1H ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors GRIN3A APBA1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D KIF17 GRIN1 DLG1 GRIN2A CASK LIN7A DLG2 LIN7C NBEA DLG3 LRRC7 LIN7B DLG4 NEFL CAMK2G GRIN3B DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation UHRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 DNMT3L H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DBT DLD DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis NCAN CHST15 CSPG4 BGN DCN BCAN VCAN DSEL CHST14 DSE UST CSPG5 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 KPNA2 H2BC15 TP53 H2BC11 ATM UBE2N PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CDK2 CCNE2 RB1 CCNE1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration ITGA5 ITGBL1 MMP13 AKT1 AKT2 CBFB AKT3 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry AGRN FURIN NCL EGFR GPC1 LY96 GPC3 GPC2 CD14 GPC5 RAB5B GPC4 RAB5C GPC6 CX3CR1 HSPG2 IGF1R SDC1 RAB5A SDC4 SDC2 SDC3 TLR4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED19 MED18 SREBF2 MED11 WNT1 RELA MED9 MED29 MED28 MED22 TGFB1 MED21 CDK19 MBD3 MED13L ANGPTL4 LPL GATAD2B GATAD2A CDK8 SMAD1 SMAD4 LEP CHD4 CIDEA SMARCD3 CCND3 MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MTA3 CARM1 EBF2 RBBP7 BMP7 CDK4 KLF4 EP300 MED1 MED30 MED31 MED8 MED4 MED6 MED7 ELOVL3 CEBPA HNRNPU RXRA NFKB1 HDAC1 KLF5 HDAC3 CEBPB TBL1X PCK1 NCOA1 EGR2 FABP4 NCOR2 COX7A1 CHD3 NCOR1 TBL1XR1 PLIN1 HDAC2 THRAP3 FAM120B PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC ADIPOQ HELZ2 MED16 MED15 CREBBP MED17 CHD9 MED12 MED14 MED13 TNF MED10 EBF1 WNT10B NR2F2 ADIRF SLC2A4 ZNF638 TGS1 CEBPD ZNF467 MED27 MED26 MED23 MED25 MED24 MED20 PPARG PPARA DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction SOS1 CRK STAT5A STAT5B STAT3 PIK3R2 PIK3R1 PDGFB NRAS PLCG1 STAT1 PTPN11 PIK3CB RAPGEF1 NCK2 NCK1 RASA1 SRC PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling JUN GNG13 ZNF217 FKBP5 EBAG9 GNB2 KDM4B YY1 GNB1 GNB4 DDX5 GNB3 GNB5 GNGT1 GPAM GNGT2 SPHK1 GNG3 CXCL12 ESR1 GNG2 GNG5 GNG4 GNG7 GNG8 POU2F1 NOS3 TBP HSP90AA1 EGF EGFR CDKN1B S1PR3 CARM1 H2AX H2AB1 H2AC19 MMP2 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 MED1 H2AC8 PRKCZ H2AC6 CTSD H2AC7 HRAS H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 MMP3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 PIK3R3 PIK3CA CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 HBEGF H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 HDAC1 NRAS H2AC20 HSP90AB1 KDM1A MAPK1 GNAT3 CCND1 PTGES3 NRIP1 FKBP4 NCOA1 SRF MAPK3 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 ESR2 AGO2 SRC TNRC6A TNRC6B GNAI3 XPO1 GNAI1 GNAI2 AKT1 CALM1 AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 MMP9 KANK1 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG KAT2B FOXA1 ZDHHC7 TLE3 KPNA2 PPID TGFA USF1 CAV2 FOS FOXO3 GREB1 ELK1 IGF1R GNG10 CHD1 PTK2 MMP7 EREG PGR TFF3 UHMK1 TFF1 BTC ZDHHC21 CAV1 GNG12 CXXC5 EPGN AKT3 GNG11 USF2 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors HRH3 HRH2 HRH4 HRH1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters SLC24A2 SLC24A3 SLC41A2 SLC41A1 SLC30A10 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 CP SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC40A1 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC8A1 SLC8B1 SLC24A1 SLC8A2 HEPH SLC24A4 SLC11A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SRI SLC9A8 SLC9A9 SLC9A1 SLC24A5 SLC39A4 SLC8A3 SLC11A2 CALM1 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation POLE4 POLE POLE2 PRIM2 POLE3 PRIM1 POLA1 POLA2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 CAVIN1 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules LRFN1 PTPRS PTPRF GRIA1 GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG3 RTN3 DLG4 FLOT1 LRFN3 FLOT2 PTPRD GRIA3 LRFN2 GRIA4 LRFN4 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA PLA2G2D MIGA1 PLD1 PLA2G2E DDHD2 AGPAT2 PLA2G5 DDHD1 PLA2R1 PLA2G10 GPD1 GPD1L PLD6 GPAM PLA2G2A GPAT2 LPCAT1 PLA2G4A PLD2 ALPI GPD2 GNPAT LIPI ACP6 LIPH PLA2G12A PLA2G4D GPAT4 PLA2G4B GPAT3 AGPAT5 PLA2G1B LPCAT4 AGPAT1 AGPAT3 AGPAT4 LCLAT1 PLA2G2F MIGA2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism ACSL1 FADS1 ELOVL5 ELOVL2 ABCD1 ELOVL3 ELOVL1 FADS2 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity HTT HDAC1 HDAC3 GPS2 SIN3A LBR HIPK2 PRKACA TBL1X AURKB FOXG1 NCOR2 TNRC6C MOV10 NCOR1 AGO3 TBL1XR1 AGO4 CAMK2B AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A CAMK4 CALM1 CAMK2G SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections IFNA2 IFNA8 RELA IFNA13 IFNA14 IFNA16 SAP30L IFNA17 NPM1 ITCH IFNA10 IFNA21 IFNB1 ISG15 NR3C1 PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP YWHAE VPS41 NPIPB3 VPS45 NMI PARP10 PARP6 SFTPD CHD4 IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 MTA2 VPS33B RIPK3 REST KPNB1 FNTA CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A VAV1 UBE2N CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 PTGES3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 FKBP4 OST4 EDEM2 MOGS SDC4 ZDHHC11 IFNGR1 DDOST SDC2 IFNGR2 MGAT4C SDC3 ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 SUMO1 GPC5 GPC4 GPC6 KEAP1 RBX1 TRIM25 SDC1 VHL ISCU BTK IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TLR8 KPNA2 MAP3K7 VCP NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA MAVS TAB1 GJA1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C PYCARD NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 TRAF3 RANBP2 TRAF6 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 BECN1 NUP50 NUP35 RBBP4 NUP54 NUP37 NOD1 RBBP7 NOD2 NCK1 AKT2 PDPK1 RPS27 ITGB1 TLR9 PIK3C3 SOS1 SNRPD2 SNRPD1 SNRPD3 PIK3R4 BST2 PRMT1 CHUK TJP1 PCBP2 PTPN11 CASP1 JAK2 ZCRB1 SYK SNRPG SNRPE PPIH PPIG SNRPF AP2A1 SNRPB AP2A2 DDX5 AP2M1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 SAR1B IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 TLR1 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 TLR2 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 SAP18 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 IGLC2 S1PR1 JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 IGLV3-19 MTA3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 RPS4Y1 IGLV3-1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 RPS17 IGKC RPS15A IGKV1-39 IGLV3-21 RPS16 RPS19 IGKV1-33 BRD4 RPS18 RPS3 CRBN RPS2 IGLC7 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 RPS13 IGLC6 RPS12 IGKV1-5 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 PDCD1 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 HLA-H HLA-B HLA-C ATG14 HDAC1 HLA-F HSP90AB1 HLA-G HLA-E YWHAB FKBP1A IKBKE AKT1 IRF7 NUP214 SFN YWHAZ UBA52 TUBB UBB UBC RPS27A UBE2V1 PSMC6 CAV1 FURIN ATP1B3 ROCK1 ATP1B2 ROCK2 ATP1B1 CUL3 MBD3 STAT1 GATAD2B GATAD2A ZBP1 SEC23A TBK1 B2M IRF3 STING1 HLA-A FXYD4 FXYD3 FXYD2 FXYD1 PALS1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 UVRAG ANO5 MAP1LC3B ANO2 ANO3 HSP90AA1 ANO1 RB1 ATP1A4 ATP1A3 ATP1A2 FNTB SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 EP300 IL6R RUNX1 NRP1 MASP1 NFKB1 SRPK1 KDM1A HSPG2 ITGA4 AGRN CHD3 HDAC2 ST6GALNAC2 SIKE1 GSK3B CSNK1A1 ST6GAL1 ST6GALNAC3 ST6GALNAC4 ARID4B SAP30 CREBBP SP1 ST3GAL4 NFE2L2 BCL2L1 ST3GAL1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 TAB3 TAB2 CTSL IFNA5 IFNA4 IFNA7 IFNA6 AKT3 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib ERBIN HSP90AA1 ERBB2 CDC37 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines STAT6 TBK1 STING1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A GALNS BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins KPNA7 KPNA4 KPNA5 KPNA3 RPN2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 SPCS2 PRKG2 SPCS1 OST4 SEC11A SEC11C DDOST TMEM258 DAD1 OSTC CANX CALR ACOT2 STT3A STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 KPNA1 IPO7 DNAJB11 P4HA1 UBA52 P4HA2 P4HA3 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UBB UBC DNAJC3 RPS27A KPNA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling CAP1 ABL2 CLASP1 CLASP2 SLIT2 ABL1 ROBO1 CAP2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 LEF1 SOX10 SMARCC1 CTNNB1 SMARCC2 GPR143 ACTB SMARCE1 ACTL6A SYTL2 PMEL TFAP2A MYO5A RAB27A TYR AKT2 MYRIP MAPK14 DPF1 BCL7A DPF2 DCT BCL7C IRF4 BCL7B DPF3 SMARCA2 SMARCA4 TYRP1 MLANA USF1 MLPH SS18L1 ARID1A ARID1B ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs PRKAG3 CAMKK2 PRKAB2 PRKAA1 PRKAA2 CALM1 PRKAG1 PRKAB1 PRKAG2 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 TXNRD1 RPS17 SARS1 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A PAPSS2 RPL6 PAPSS1 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 EPRS1 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2A UBE2C UBE2L3 UBE2E1 UBE2D1 UBE2W USP7 USP5 UBE2S UBA52 UBA1 UBE2K UBE2Z CDC34 UBE2Q2 UBE2E3 UBB UBE2R2 UBC UCHL3 RPS27A UBE2T OTULIN UBA6 UBE2D2 USP9X UBE2H UBE2G1 UBE2G2 UBE2B PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds CYB5B CYP51A1 CYP4B1 CYB5R3 CES3 CYP27A1 CYP39A1 CYP3A5 AOC1 CYP2A13 CES1 FMO3 CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP7A1 CYP1B1 CYP2C19 CYP2D6 CMBL ALDH3A1 FDXR POR CES2 MAOB MTARC2 MAOA CYP8B1 MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP46A1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 RXRA ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 ARNT2 PTGES3 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR CYP4F12 PTGIS PTGS1 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP4F11 AIP CYP11B1 TBXAS1 ADH1C ADH1A ADH4 PAOX ALDH1A1 ALDH2 CYP3A4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR2 TGFB1 TGFBR1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) GP5 SOS1 GP9 CRK SHC1 MPL FN1 GP1BA THPO RASGRP2 RASGRP1 RAP1B RAP1A CSK ADRA2C FGB ADRA2B RAPGEF3 FGA ADRA2A RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 F2 AKT1 PTK2 ITGB3 ITGA2B GP1BB SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R HRAS SOS1 IGF2 IGF1 IGF1R NRAS GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 TJP1 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose DPM3 DPM1 DPM2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH JUN SEL1L WWC1 NEURL1B DLGAP5 HES5 PTCRA MIB2 ITCH PBX1 MIB1 HEYL ATP2A3 NEURL1 TACC3 MAMLD1 ATP2A2 ATP2A1 YBX1 ELANE NUMB PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC MAML2 NOTCH2NLB MAML1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC1 GZMB APH1A DLL4 PSENEN NCSTN APH1B CCND1 PSEN2 ADAM10 PSEN1 RBPJ TMED2 FCER2 TNRC6C MOV10 RFNG MFNG AGO3 B4GALT1 MDK AGO4 ACTA2 MYC AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 HIF1A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 KAT2B KAT2A HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 NBEA FURIN DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 STAT1 CDK8 SMAD3 DTX4 JAG2 ADAM17 ARRB1 ARRB2 WWP2 EGF EGFR HDAC5 PLXND1 HDAC8 HDAC9 HDAC6 HDAC7 E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 HDAC10 EP300 HDAC11 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 TBL1X NCOR2 FABP7 NCOR1 TBL1XR1 SNW1 HDAC4 HDAC2 FLT4 HES1 CCNC CREBBP ST3GAL4 LFNG ST3GAL6 JAG1 ST3GAL3 SEM1 DLL1 SKP1 CUL1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA NGFR LINGO1 NGF MAG OMG RTN4 MCF2 RHOA DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis JUN PRDX2 PRDX1 CDK5 CDC25C CDKN2A CDC25B CDC25A C1QBP APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 TP53 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) RPS6KA1 CLTC CLTA AP2A1 AP2A2 NGF AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB VGF EP300 JUNB HRAS FRS2 MAP2K1 CRKL MAP2K2 PIK3CA SOS1 DUSP4 DUSP3 VRK3 DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 ADCYAP1 ADCYAP1R1 YWHAB SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA ATF1 BRAF MAP2K5 RAPGEF1 MAPKAPK3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTRK2 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin KLF4 INS GCG PCSK1 BCHE IGF1 SPCS3 SPCS2 LEP SPCS1 SEC11A UCN SEC11C ACHE MBOAT4 PLA2G7 CRHR2 GH1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation BTRC DDB1 COPS7B COPS7A CUL4A COPS3 LRR1 COPS6 CCNF COPS5 COPS8 FBXO7 FBXO9 WSB1 FBXO2 CDKN1A FBXL18 FBXL7 SQSTM1 FBXL8 FBXL4 DTL LRRC41 UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 HIF3A PSMD7 ELOB ELOC SOCS2 PSMD2 KLHL2 RBX1 SOCS6 KLHL3 PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL KLHL9 SPSB2 SPSB1 DCAF8 KBTBD6 DCAF5 KLHL5 DCAF4 PSMA5 DCAF6 PSMA6 WSB2 PSMA3 KBTBD7 OBSL1 PSMA4 KBTBD8 DCUN1D5 PSMA1 SPSB4 DCUN1D3 DCUN1D4 PSMA2 DCUN1D1 DCUN1D2 FBXO27 UBA52 COMMD8 PUM2 NPLOC4 PSMD12 DDA1 PSMD11 ANKRD9 FBXO21 UBXN7 PSMD14 COMMD2 FBXO22 COMMD1 PSMD13 COMMD6 COMMD7 PSMA7 COMMD4 FBXW12 COMMD5 PSMB6 SPSB3 FBXW8 PSMB7 CCDC8 CISH PSMB4 FBXO17 CUL9 DPP3 UFD1 PSMB5 FBXO15 UBD NAE1 DCAF7 UBB SOCS5 PSMB2 WDTC1 PSMB3 LMO7 CCDC22 FBXO10 COMMD10 UCHL3 FBXO11 UBC TULP4 FBXO4 PSMB1 KLHL41 DCAF16 KCTD7 DCAF17 FBXO6 DDB2 RPS27A FEM1C DCAF10 KLHL42 DCAF11 FEM1A FBXW4 CUL7 FEM1B FBXW5 CUL5 NEURL2 NEDD8 FBXW10 ADRM1 ERCC8 FBXW7 PSMC5 FBXW9 PSMC6 KLHL11 PSMC3 PSMC4 FBXW2 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 FBXL3 UBA3 FBXL5 MUL1 UBE2M GPS1 KBTBD13 CUL3 VCP COPS4 COPS2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 ASB16 FBXL20 ASB10 WDR5 SENP8 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 SKP2 RBBP5 ASB1 RBBP7 COP1 SOCS3 COMMD9 FBXO32 BIRC5 DCAF13 COMMD3 KCTD6 AMER1 UBE2D1 BRCA1 CAND1 NFE2L2 FBXW11 FBXL21P PALB2 SEM1 SKP1 CUL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC MMACHC RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle HNRNPC CCT6A CCT7 RBMX DBN1 HSP90AA1 CDC37 HSP90AB1 TWF1 CCT2 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B CUL3 PHIP TXNL1 SRRM1 TRA2B ACTG1 MYO6 STK38 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation TRAF2 RELA MAP3K7 NFKB1 TRAF6 UBA52 USP14 NFKB2 CHUK NOD1 NKIRAS1 NOD2 NKIRAS2 USP18 IKBKG UBB IKBIP RIPK2 IKBKB UBC RPS27A ALPK1 LRRC14 NLRX1 IRAK1 UBE2V1 NLRC5 NFKBIA AGER IRAK2 TIFA S100A12 TAB1 APP S100B SAA1 TAB3 TAB2 HMGB1 TP53 NFKBIB CASP8 UBE2N THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 TBXA2R GNG7 AAMP GNA11 GNGT1 GNG8 GNA13 GNGT2 GNG10 GNG12 GNG11 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes SRPRB ATP6V0D1 TPP1 CXXC1 PREB HDGF PPP2R5B KDELR3 ACADVL SHC1 ADD1 PDIA6 DNAJB11 DCTN1 SERP1 WFS1 SEC31A TLN1 DNAJC3 EXTL2 CUL7 FKBP14 GOSR2 MYDGF EXTL3 PLA2G4B HYOU1 EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 GSK3A EDEM1 WIPI1 YIF1A SYVN1 ARFGAP1 PDIA5 CTDSP2 SRPRA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 FGF18 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A TP53 ING2 PIP4K2B MAP2K6 PIP4P1 EP300 PIP4K2C ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B PPP2R1A TICAM1 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA PPP2CB TLR3 MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes CREBBP TALDO1 MAFG PGD NFE2L2 TKT EP300 G6PD CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL STAT3 GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 HDAC3 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 GBA1 ACTB CCNE1 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 GNG10 GNG12 GNG11 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells FGF10 ONECUT3 ONECUT1 PDX1 NKX6-1 PTF1A HNF1B RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G NFIX POLR3H SSB POLR2K NFIA POLR3K POLR2L NFIB NFIC POLR1C POLR1D ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription DHFR PCNA ORC1 TK1 CDT1 CDC6 HDAC1 CDK1 RRM2 E2F1 RBBP4 CDC45 FBXO5 TFDP1 TFDP2 LIN54 LIN37 CCNE1 LIN9 POLA1 TYMS LIN52 E2F4 E2F5 E2F6 CCNA1 RBL2 RBL1 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids CYP2F1 CYP4A22 CYP4B1 CYP2D6 CYP4F12 CYP4F22 CYP4F3 CYP4F8 CYP2A13 CYP2B6 CYP2J2 CYP4F2 CYP4A11 CYP2A7 CYP4F11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates MUS81 FIRRM BLM SLX4 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS HRAS SOS1 NTF4 NTRK2 BDNF NRAS DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency MCCC2 PC ACACA PCCA HLCS MCCC1 PCCB CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants ALK VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly CASP5 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO3 FMO1 FMO2 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation DRG2 RCCD1 ZC3H15 JMJD6 ASPH U2AF2 RIOX2 RPS6 F9 RPL8 RWDD1 JMJD4 KDM8 RPS23 JMJD7 RIOX1 ETF1 OGFOD1 RPL27A DRG1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR2 TGFB1 TGFBR1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP RBPJ MAML2 MAML1 KAT2B ONECUT3 KAT2A ONECUT1 HES1 SNW1 EP300 NEUROG3 HNF1B MAMLD1 MAML3 NOTCH1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 TACC3 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 CUL1 NOTCH4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN52 HDAC1 CDK1 E2F4 E2F5 E2F1 RBBP4 CCNA2 TFDP1 TFDP2 LIN54 LIN37 MYBL2 LIN9 RBL2 RBL1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2E1 CYP3A7 RXRA CYP51A1 CYP2F1 CYP4B1 CYP2W1 ARNT2 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP27A1 CYP39A1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR PTGIS CYP4F12 CYP3A5 CYP2A13 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP7A1 CYP1A1 CYP1B1 CYP2C19 CYP4F11 CYP11B1 TBXAS1 CYP2D6 FDXR POR CYP8B1 CYP2C18 CYP2B6 CYP46A1 CYP2S1 CYP4V2 FDX1 CYP3A4 CYP3A43 FDX2 CYP2A7 CYP2A6 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions CACNG2 CACNG3 CACNG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 STX1B CACNG8 DLG4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI PLA2G2D PLA2G2E MBOAT7 PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4C PLAAT3 PLA2G2A PLA2G1B PLBD1 PLA2G2F PLA2G4A DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus RB1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME3 ME2 VDAC1 WDR26 PDHB RMND5B PC LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 LDHC MPC1 PDK1 LDHB MPC2 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GLO1 GID4 GID8 UBC FAHD1 MPC1L RPS27A LDHAL6A LDHAL6B PDK4 GPT DLD SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT KIT DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 STRAP HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 TFAP2A HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A ARID1A FOXA2 TGIF2 EED RB1 RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX KLF4 H2AB1 SP1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis CYB5B SPTLC1 OSBP SPNS2 SPTLC2 SPTLC3 CSNK1G2 VAPA ABCG2 KDSR MFSD2B SPHK1 FA2H ORMDL2 ORMDL3 SPTSSB DEGS1 SPTSSA DEGS2 SPHK2 SAMD8 SGMS1 CERS3 ORMDL1 SGMS2 CERS4 ABCC1 CERS5 CERS6 CERS1 CERS2 PPM1L VAPB PRKD3 PRKD2 PRKD1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development HNF1A MAFA RFX6 INSM1 FOXA3 GCK ONECUT3 ONECUT1 HES1 PDX1 INS NKX6-1 PTF1A PAX6 SLC2A2 MAMLD1 RBPJ CREBBP MAML2 IAPP FGF10 MAML1 KAT2B KAT2A FOXO1 EP300 SNW1 AKT2 NEUROG3 HNF1B HNF4G MAML3 AKT1 FOXA2 NEUROD1 NOTCH1 NKX2-2 AKT3 PAX4 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PRKCA FES SOS1 STAT5A STAT5B PTPRU SH2B2 LYN CMA1 STAT3 PIK3R2 CBL FER PIK3R1 TEC GRAP NRAS GRAP2 JAK2 STAT1 SOCS1 CHEK1 MMP9 PTPN11 PTPN6 GRB10 YES1 RAC1 HRAS LCK FYN KIT SOCS6 SH2B3 GRB7 GAB2 PIK3R3 PIK3CA VAV1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 YWHAE YWHAQ YWHAG ZNF385A YWHAH BTRC UBE2V2 UBE2N HERC2 PLK3 CDKN1A CDKN2A CDC7 CDK2 CDC45 MDC1 PHF20 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 PSMD1 SFN YWHAZ PSMA5 PSMA6 PIAS4 PSMA3 PSMA4 BRCC3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 BABAM1 PSMB6 BABAM2 PSMB7 PSMB4 UIMC1 PSMB5 CSNK1E UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 CCNB2 CDC25A PKMYT1 WEE1 CLSPN MDM2 MDM4 NUP107 NUP160 RNF168 NUP85 NSD2 NUP43 RANBP2 SEC13 CDC25C NUP133 CDKN1B ABRAXAS1 TP53BP1 NUP37 ERCC6L ZWILCH BUB1B CCNE2 CDC20 NEK11 PPP1CC CCNE1 PPP2R1B H2AX PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 COP1 H2BC26 SGO2 H2BC12L DYNC1LI2 H2BC21 ZW10 MAD1L1 RNF8 CDCA8 PMF1 SKA1 CHEK2 SKA2 DSN1 H2BC17 H2BC12 H2BC13 H2BC14 RCC2 H2BC15 NDC80 ZWINT H2BC11 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 GSK3B CSNK1A1 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 GTSE1 RFC4 RMI1 PCBP4 RFC2 FBXW11 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 MCM7 MCM8 RPA3 SKP1 RAD17 RAD1 CCNA2 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 CLIP1 CUL1 ORC5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25C CDC25A CDC7 CDK2 CDC45 CHEK1 ATRIP CLSPN RFC5 RFC3 RFC4 RFC2 MCM10 RPA1 DBF4 HUS1 RPA2 MCM7 MCM8 RPA3 RAD17 RAD1 MCM3 MCM4 RAD9B MCM5 MCM6 ATR MCM2 RAD9A ORC5 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B SLC22A2 SLC22A1 MAOA PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination FZD5 FZD4 UBC FZD6 RPS27A USP8 FZD8 UBA52 RSPO3 WNT3A LRP5 RNF43 ZNRF3 RSPO2 RSPO1 LGR6 LRP6 LGR5 RSPO4 LGR4 UBB RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c ALG6 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest SFN PCNA CCNB1 EP300 PRMT1 CDC25C AURKA CDK1 E2F4 BAX TP53 CARM1 TFDP1 TFDP2 GADD45A RBL2 RBL1 ZNF385A OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism PM20D1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 MMR%REACTOME%R-HSA-5358508.3 MMR LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB NBEA CALM1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 KPNA5 ARIH1 KPNA3 PIN1 EIF2AK2 ISG15 MAPK3 STAT1 EIF4E IRF3 RIGI NUP205 POM121 NUP107 TRIM25 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 UBE2E1 NUP88 NUP43 RAE1 NEDD4 KPNA1 NDC1 RANBP2 SEC13 UBA52 PLCG1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 NUP35 NUP54 NUP37 JAK1 KPNB1 USP18 UBB EIF4E3 IFIT1 PPM1B EIF4E2 UBC FLNB MX2 RPS27A MX1 EIF4G3 EIF4G2 UBA7 EIF4A2 EIF4A1 KPNA2 EIF4G1 UBE2L6 EIF4A3 HERC5 UBE2N MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 HSPB1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 HSPA1A EIF4G1 PSMD2 PSMD3 PSMD1 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors LTB4R2 GPR17 CYSLTR1 CYSLTR2 LTB4R NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants ALK CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes CREBBP CITED2 BBC3 STK11 BCL6 FOXO1 EP300 NFYA NFYB NFYC BCL2L11 FASLG FOXO3 PINK1 FOXO4 DDIT3 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 TSPOAP1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus NEURL1B UBA52 DNER APH1A DLL4 MIB2 ITCH PSENEN DTX1 NCSTN MIB1 DTX2 APH1B NUMB PSEN2 DLK1 NEURL1 ADAM10 CNTN1 PSEN1 UBB UBC RPS27A DTX4 JAG2 JAG1 ADAM17 DLL1 ARRB1 ARRB2 NOTCH1 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis NKX2-5 LEF1 ISL1 CTNNB1 SRF KAT5 FOXO4 SMAD1 SMAD4 HEY1 MEF2C KAT2A HAND2 MESP1 HEY2 GATA6 TBXT TBX20 SMYD1 TBX1 EOMES MYOCD HAND1 LDB1 TBX5 WDR5 GATA4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 SERPINB13 CTSV SOCS3 CTSL CTSK CBFB SOCS4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 APOB S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 GSDMD BIRC3 GSDME USP14 BTRC TLR7 RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 HSP90B1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 LGMN MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB UNC93B1 SIGIRR TLR3 IRAK3 MEF2C CTSS UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 CNPY3 SAA1 TAB3 TLR8 SKP1 TAB2 CTSB TP53 NFKBIB FOS CTSV ELK1 CTSL CTSK MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 ABCB6 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 EGF EGFR NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 TACC3 PSEN1 UBB UBC RPS27A YBX1 JAG2 JAG1 DLL1 NOTCH3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose PMM1 MPI HK1 GMPPB PMM2 GMPPA PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 RBBP4 HLA-DRB5 TRAV19 RBBP5 HLA-DRB4 RBBP7 HLA-DPB1 TRAV8-4 HLA-DRA CDK4 HLA-DRB3 CD4 HLA-DRB1 H2AX HLA-DQB2 H2AB1 HLA-DQB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PTPN11 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 CSK PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 PTPN6 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions CD47 SIRPB1 PTK2B SIRPA FYB1 SIRPG PTPN6 PTK2 SKAP2 TYROBP PTPN11 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFAM TFB2M NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 GNGT1 RHOA GNGT2 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PDPK1 GNG10 AKT1 GNG12 AKT3 GNG11 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ2 KCNJ4 KCNJ14 KCNJ12 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP TXNIP SIRT1 KAT2B SIRT3 FOXO3 FOXO1 EP300 TXN FOXO4 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PALS1 PATJ TJP1 CRB3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 LYN EPO EPOR IRS2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP1 HLA-H PIK3R4 HLA-B SEC13 HLA-C ATG14 HLA-F HLA-G HLA-E BECN1 HSPA5 SEC24D PDIA3 SEC24C TAP2 SAR1B SEC31A TAP1 TAPBP CANX CALR SEC23A B2M HLA-A SEC24B SEC24A ERAP2 PIK3C3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade FRAT2 APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 FRAT1 PPP2R1A PPP2R5E PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 PTK6 STAT3 SOCS3 STAP2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy CETN1 PARK7 UBC RNASE1 GFAP CFTR PLIN3 RPS27A HSP90AA1 HSPA8 UBA52 ARL13B HSP90AB1 HBB HDAC6 PCNT EEF1A1 PLIN2 LAMP2 IFT88 UBB SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome DDX5 ZCRB1 VHL RB1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System KCNJ8 AP2A1 KCNJ11 ABCC8 ABCC9 ADCY9 NTRK3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT RTN3 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 DBNL KCNK6 KCNK7 KCNK1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 GRM1 GRM5 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 FLOT1 FLOT2 ARHGEF9 EPB41L3 GJC1 GJA10 GJD2 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 KCNG1 KCNG2 BCHE KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 PRKCA KCNK17 KCNK18 KCNQ1 KCNQ2 KCNQ3 SNAP25 KCNQ4 RAB3A KCNQ5 SLC32A1 KCNV1 SYT1 SLC6A13 KCNV2 ABAT KCNN1 KCNN3 SLC6A1 KCNN4 CPLX1 RIMS1 KCNF1 KCNC1 ALDH5A1 KCNK9 DNAJC5 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 GIT1 KCNAB1 KCNAB2 KCNAB3 KCNA10 IL1RAPL1 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 HSPA8 KCNK2 VAMP2 KCNK3 HCN2 KCNK4 HCN1 SLITRK3 CAMKK1 CAMKK2 SLITRK5 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 SYT2 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 KCNN2 PTPRF SYN3 SYN2 HRAS SLC6A11 PDPK1 PTPRS ARL6IP5 HOMER3 CACNA2D1 CACNA2D3 EPB41 STXBP1 EPB41L5 NRAS EPB41L2 HOMER1 HOMER2 CHAT PPFIBP1 PPFIBP2 GRIP1 MAPK1 GNAT3 SLC6A4 PANX1 CHRNB2 PANX2 NSF SIPA1L1 CHRNB4 DLGAP1 CHRNB3 GABRG3 DLGAP3 DLGAP2 GRIP2 GABRG2 SLC18A3 DLGAP4 CHRNA1 BEGAIN CHRNA3 SLC17A7 CHRNA2 MAPK3 APBA3 CHRNA5 APBA2 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 SHARPIN GRIK4 LRRC4B GRIK1 SYT9 GRIK2 GRIA1 SYT7 GABRR3 LRRTM3 CAMK2B GABRR2 GRIA2 LRRTM4 GABRR1 LRRTM1 CAMK2D LRRTM2 NPTN SRC ACTN2 HTR3E IL1RAPL2 HTR3C SHANK3 CAMK2A HTR3D NRG1 SHANK2 GRIN2C HTR3A SHANK1 GRIN2B HTR3B NLGN3 PICK1 NRGN NLGN1 GRIN2D GNAI3 NLGN2 AKAP5 GRIN1 NRXN1 GNAI1 DLG1 NRXN3 GRIN2A NRXN2 NCALD GNAI2 DLG2 SLITRK2 CHRND DLG3 SLITRK1 LRRC7 GLRA1 SLITRK4 DLG4 CACNG8 SLITRK6 NEFL GLRA2 PDLIM5 CALM1 GLRA3 NLGN4Y CHRNG CAMK2G NLGN4X SYT10 CHRNE SYT12 CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling JUN NTRK3 NTF3 PDGFB IRAK1 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PDGFRA RAC1 KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 ESR2 HDAC2 SRC NR4A1 NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 GSK3B IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis IRF1 IRF2 CYCS CHMP3 CHMP6 CHMP7 BAK1 ELANE GZMB GSDMD GSDME BAX TP63 IL18 IL1A IL1B CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A HMGB1 TP53 CASP5 CASP1 CASP4 CASP3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein BID BAK1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 POLB LIG3 APEX1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine CTH FMO1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 TST ETHE1 SLC25A10 CDO1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 GCGR GNGT1 GCG GNGT2 GIP GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCYAP1 ADCYAP1R1 GNG10 GNG12 GNG11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TFAP2A CDKN1A TFAP2C MYC DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG3 PPARGC1A MAPK12 PRKAB2 PRKAA2 MAPK14 MAPK11 PRKAG1 PRKAB1 PRKAG2 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 FAM13B WIPF1 WIPF2 CYFIP2 WIPF3 ARHGAP44 PREX2 DOCK11 ARHGDIA NISCH RALBP1 ARHGAP45 SPATA13 ARHGEF25 CIT IQGAP1 PLD1 FGD5 IQGAP2 CHN2 IQGAP3 ARHGAP22 FARP2 ARHGAP20 SRGAP3 SRGAP1 ARHGAP29 ARHGAP27 ARHGAP24 PKN2 ARHGAP33 PKN1 ARHGAP31 FAM13A ARHGAP30 DOCK6 ARHGAP9 DOCK9 DOCK8 DOCK7 WASL ARHGAP4 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARHGAP10 CDC42EP4 TRIO RASGRF2 WAS PLEKHG6 PARD6A CHN1 PAK6 PREX1 SH3BP1 MCF2L PAK3 RAC1 WASF3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 SRGAP2 ARHGEF10 CDC42BPA DEF6 PLEKHG2 KTN1 ARHGEF15 DLC1 PIK3R3 ARHGEF19 PIK3CA DIAPH3 ARHGEF18 ITGB1 VAV1 VAV2 TIAM2 TIAM1 SOS1 ARHGEF4 ARHGEF7 PIK3R2 SOS2 PIK3R1 ARHGEF5 NGEF ARHGEF6 KALRN GNA13 ABR SYDE2 ECT2 ARHGEF39 MCF2 ARHGAP12 PLD2 CDC42 ARHGAP25 ARHGAP23 DOCK5 DOCK4 FMNL1 DOCK3 LAMTOR1 ALS2 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 ARHGAP42 BAIAP2L1 OPHN1 ARHGDIB EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PAK1 RACGAP1 NHS ABL2 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 GIT2 CAV1 MCAM SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 POU2F1 TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP MAPK1 CSTF3 CSTF2 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 SNRPB SRSF9 RBM8A CPSF4 CHTOP CPSF1 ALYREF CPSF3 CPSF2 YBX1 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants FLT3 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC YWHAE YWHAQ YWHAG YWHAH TRAF2 TNFSF10 UNC5A KPNA1 DAPK1 UNC5B DAPK2 DAPK3 FADD BIRC2 CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 E2F1 APPL1 DFFB DFFA DBNL ACIN1 TFDP1 KPNB1 TFDP2 GAS2 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 ARHGAP10 TICAM1 PKP1 LY96 AKT2 BMF BMX STK24 STK26 AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 PPP3R1 TP53BP2 DNM1L DSP OMA1 OCLN OPA1 DSG1 DSG3 TNFRSF10B TNFRSF10A PLEC STAT3 DYNLL1 UACA ADD1 BAK1 GZMB CDKN2A MAGED1 DYNLL2 MAPK1 PPP1R13B MAPK8 CTNNB1 BCL2L11 TJP1 FAS FASLG MAPK3 BAD PMAIP1 CDH1 YWHAB SATB1 PSMD8 PSMD6 PSMD7 PSMD2 CASP6 PSMD3 AKT1 PSMD1 PRKCD APC SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BAX PSMD13 TP63 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC BBC3 BCL2 DSG2 PSMB1 RPS27A BCL2L1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TP73 TP53 PAK2 PTK2 CASP9 CASP7 APAF1 DIABLO AKT3 CASP3 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 CYP2U1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CD36 ITGB5 CYBB CYBA ITGAV INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF28P SCOC SYS1 KDELR1 GOLIM4 KDELR3 GCC2 GCC1 RAB43 RAB41 GOLGA5 KIF5C GOLGA1 ARFIP2 KIF21A KIF21B RHOBTB3 KIFAP3 KLC1 COG8 KLC4 COG7 KLC3 COG6 KLC2 COG5 COG4 COG3 COG2 COG1 RINT1 RAB30 RAB36 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 ARL1 KIF3B SEC22B MAN2A2 VTI1A KIF3C RAB9A RAB6B RAB9B KIF5B RAB39A KIF5A KIF18B KIF4B ALPP KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 M6PR MAN1A2 KIF13B TMED3 VPS45 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 KIF6 BET1L STX5 KIF27 COPZ1 RAB33B KIF9 KIFC2 KIFC1 NAA35 NAA38 VAMP4 PAFAH1B3 ARF5 NAPA GBF1 TGOLN2 NAPB NBAS TMF1 RAB6A STX16 RAB1A STX18 RAB1B GOSR1 NAPG STX10 CYTH3 ARFRP1 CYTH2 GALNT1 CYTH4 CUX1 VPS51 VPS53 VPS52 MAN1C1 SNAP29 BNIP1 ARFGAP3 STX6 ARFGAP2 VPS54 DYNC1LI1 CAPZB CYTH1 RIC1 DYNC1LI2 GALNT2 ARCN1 ZW10 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF MAN2A1 KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 PLIN3 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 IGF2R ACTR1A ARF1 GOLGA4 VAMP3 DCTN2 CAPZA1 DCTN3 GOSR2 RACGAP1 YKT6 ARFGAP1 USP6NL HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 HS6ST1 HS6ST2 HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function JUP PRDM8 CTNND1 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism CSPG4 GUSB ARSB CHST3 CHST14 DSEL DSE UST CHST15 IDUA CHPF NCAN HEXB CHSY1 HEXA CHST11 CHST12 BGN GLB1L3 CHSY3 CHST13 DCN GLB1L2 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b MPI NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors LPAR4 ADORA2B GPR17 P2RY10 P2RY11 LPAR6 ADORA2A P2RY12 P2RY6 P2RY13 P2RY2 P2RY14 P2RY1 P2RY4 ADORA3 ADORA1 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy MAP1LC3A FUNDC1 VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 ULK1 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN CSNK2A1 TOMM40 CSNK2A2 UBE2D2 UBE2D3 CSNK2B MTERF3 PINK1 UBE2N NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes CREBBP GEM ARNT NAMPT CDK5 RBFOX3 INS PLK2 NPAS4 MDM2 IQSEC3 MAPK1 ARNT2 BDNF XPO1 FOS BMAL1 CDK5R1 MAPK3 RET SYT10 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling JAK3 STAT5A STAT5B STAT3 IL9 JAK1 STAT1 IL2RG IL9R SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNA13 GNGT2 GNAT3 PLA2G4A GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 TBXA2R GNG7 AAMP MAPK14 GNA11 GNG8 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 P2RY1 GNG12 GNG11 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 GPRIN1 GRIA2 HDAC1 HDAC2 OPRK1 GRIN2B SIN3A SLC2A3 MET GRIN2A TRPC3 OPRM1 PTPN1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin PIK3CB RAPGEF1 SOS1 STAT5A STAT5B SHC1 PIK3CD LYN PIK3R1 PIK3CG PIK3R5 NRAS PLCG1 HRAS JAK2 GAB1 PLCG2 CRKL PIK3CA EPO VAV1 EPOR IRS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis UBC ENO1 TRIM27 RPS27A RAB7A KPNA1 SFPQ UBA52 ATP6V1H MAPK1 NOS2 CTSG VPS33B DUSP16 CORO1A PGK1 HGS RNF213 RAB5A GSK3A KPNB1 MAPK3 UBB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ACADL HADHA ACADM DECR1 ECI1 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNG13 ARHGEF9 GNB2 GNB1 ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 GNAT3 GABRG3 GABRG2 GABRB3 GABRB2 GABRB1 GNG3 GNG2 GABRR3 GNG5 GABRR2 GNG4 GABRR1 GNG7 NPTN GNG8 GNAI3 GNAI1 GNAI2 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u DPM3 DPM1 DPM2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IQGAP1 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 ADCY8 GNGT1 KCNC2 ADCY6 GCG ADCY5 GNGT2 RAP1A PRKACG PRKACA PRKACB GLP1R RAPGEF3 RAPGEF4 KCNB1 GNG3 ITPR1 KCNS3 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A KCNG2 AKAP5 GNG10 GNG12 GNG11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRA2C ADRA2B ADRB1 ADRA2A ADRA1D ADRB2 ADRB3 ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CREBBP MAFK NFE2L2 EP300 CCL2 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME UGT2B7 ABCB1 UGT1A3 AKR1C1 CYP3A4 HSD11B1 HSD11B2 ALB UGT2B17 SERPINA6 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC TAB3 RPS27A TICAM1 TLR3 TAB2 MAP3K7 TRAF6 UBA52 UBB TAB1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex NEDD4L ITGB8 ITGB5 SERPINE1 PMEPA1 FURIN PARP1 BAMBI STRAP HDAC1 RHOA TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 MAPK1 ITGA8 SKIL PPP1R15A MAPK3 TGFB2 ATP1B4 TGFB3 SKI CDK8 NCOR2 SMAD2 MTMR4 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC SMURF1 TGFBR3 E2F4 FKBP1A CCNT2 PPM1A E2F5 UBE2D3 XPO1 RBL1 TGIF1 STUB1 UBE2D1 TGIF2 TRIM33 CCNK CBL CCNC UBA52 CDKN2B COL1A2 PPP1CA USP15 CCNT1 TFDP1 TFDP2 PPP1CB PPP1CC UBB UBC SP1 UCHL5 RPS27A CDK9 EP300 JUNB PARD6A NEDD8 CGN F11R RNF111 MEN1 PRKCZ WWTR1 PARD3 USP9X LTBP4 ITGB3 ARHGEF18 ITGB1 LTBP3 ITGAV LTBP1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 C4A C3 CFB C4B_2 C2 C5 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 LTC4S PON3 ALOX5AP PON2 PON1 GPX2 GPX1 ALOX5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins FZD2 FZD5 FZD7 WNT5A FZD4 PRICKLE1 FZD1 FZD8 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 SCRIB VANGL2 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PARD6A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 DVL2 PSMC1 PSMC2 FZD3 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance CLTB ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 TYROBP DOCK1 ERBB2 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM ANK1 SEM1 FYN CLTC CLTA AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 MSI1 COL6A2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 ROCK1 ROCK2 CNTN1 DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 YES1 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PDGFB CTSG PRSS2 KLK2 A2M PECAM1 P4HB TIMP1 BMP2 PLG LAMA5 LAMA2 PPIB LAMB3 LAMC3 LAMB2 LAMA1 P4HA1 LAMA4 ELANE P4HA2 LAMA3 FN1 P4HA3 LAMB1 LAMC2 LAMC1 VTN CAPNS1 CAPNS2 CAPN2 CAPN1 BMP7 CAST DAG1 MMP1 MMP2 MMP3 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 FBLN1 LTBP3 FBLN2 LTBP1 FBLN5 LOXL1 LOXL2 COL17A1 EFEMP2 COL15A1 COL16A1 EFEMP1 COL13A1 ITGB8 GDF5 COL14A1 COL11A1 PLEC MFAP5 COL11A2 BMP4 COL12A1 MFAP4 COL19A1 LOX COL10A1 MFAP3 COL28A1 MFAP2 FBN1 COL26A1 COL27A1 COL24A1 COL25A1 ACTN1 NCSTN COL22A1 COL23A1 COL2A1 ADAM10 COL5A1 PSEN1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 SDC4 COL5A2 COL8A2 SDC2 COL20A1 SDC3 COL4A6 COL6A3 COL21A1 COL8A1 COL4A5 COL6A6 COL6A5 NTN4 CDH1 CTSS SDC1 PRKCA KLKB1 COL1A1 COL1A2 ITGA10 PRSS1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 PHYKPL CTRB2 CTRB1 P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 DTNA DTNB SSPN CTSB DDR1 MMP20 MMP24 TPSAB1 MMP13 MMP10 MMP12 MMP11 MMP14 MMP16 CASP3 MMP15 COL18A1 MMP17 MMP19 ITGA3 DDR2 ITGB4 TMPRSS6 ITGA1 DRP2 NID1 DMD NID2 JAM2 ITGA6 FURIN JAM3 PLOD3 PLOD2 PLOD1 SPP1 CAPN8 CAPN9 CAPN6 TGFB1 CAPN7 CAPN5 CAPN3 PCOLCE ADAM15 ADAM12 ADAM9 UTRN CD151 HTRA1 SCUBE3 SNTG2 SCUBE1 CRTAP VCAM1 TRAPPC4 BMP1 ITGA11 COLGALT2 MMP25 ITGAE TIMP2 SGCE SGCD SGCA SGCB ITGB7 COLGALT1 SGCG ADAM17 SNTA1 ITGAD PCOLCE2 SPOCK3 SGCZ CAPN13 NCAN CAPN14 CAPN11 CAPN12 BGN CAPN10 TLL2 DCN TLL1 SNTB1 BCAN CASK SNTB2 VCAN CMA1 ADAM8 ITGAM SH3PXD2A ITGB2 FGF2 TTR F11R CTSD ITGB3 ITGA2B ITGB1 COL3A1 ITGAV COL4A2 NCAM1 COL4A1 ITGA5 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 ITGAL TNXB LRP4 ACAN TGFB2 CEACAM6 LUM CEACAM8 TGFB3 CD47 DSPP COL9A1 CD44 ITGA4 COL9A3 COL9A2 AGRN FMOD ADAMTS4 ADAMTS5 NRXN1 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 KDR ADAMTS9 THBS1 ADAMTS16 ADAMTS14 ADAM19 FGB ADAMTS18 FGA MMP8 FGG MMP9 PDGFA CEACAM1 PXDN BSG CTSV CTSL MMP7 CTSK TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling XIAP TRAF2 FADD USP4 BIRC2 USP2 BIRC3 MIB2 CYLD RBCK1 OTUD7B RIPK1 USP21 SHARPIN TNF TBK1 OPTN TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 NEK2 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 COPS5 PSMD3 PSMD1 GSK3B CUL1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT2 GPAM PLA2G4A PLA2G2A RAB5A PIP4K2A PIP4K2B LIPI PIP4K2C LIPH BMX STARD7 RUFY1 PLBD1 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 PTPMT1 PIP5K1A PIP5K1B CHKB CHKA STARD10 ARF3 ACHE MTMR14 LPCAT1 OSBPL10 GNPAT PIP4P1 GPAT4 GPAT3 CEPT1 BCHE AGK LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 LCLAT1 PIP5K1C PCYT2 PGP PLA2R1 INPP5D ABHD4 PIK3CG PIK3R6 ABHD3 PIK3R5 ARF1 OSBPL8 RAB4A OSBPL5 OCRL SYNJ2 SYNJ1 PIK3CD PIK3C2G PIK3C2B ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B TPTE AWAT2 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 RAB14 LPGAT1 PITPNB CPNE7 CPNE6 GDE1 CPNE1 CPNE3 MFSD2A SACM1L PISD PLA1A PGS1 PTDSS2 PTDSS1 INPP5J INPP5K TMEM86B PTEN MTMR1 PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 GDPD1 GDPD3 GDPD5 PIK3CB PNPLA7 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 ETNPPL PLEKHA8 PNPLA3 PNPLA6 PTPN13 INPPL1 PLB1 ENPP6 PIK3R3 SBF1 PIK3CA SBF2 TPTE2 PIK3C3 MIGA2 MIGA1 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 INPP5E CHAT PLD4 PLD6 PLD3 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 PI4KA VAC14 PI4K2B PLD2 MTMR10 ALPI MTMR2 GPD2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A PCTP LPIN1 FIG4 LPIN2 INPP4B MGLL PLA2G4F PIKFYVE LPIN3 INPP5F PI4K2A PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 AGPAT5 PLA2G1B AGPAT1 SELENOI AGPAT3 AGPAT4 PLA2G2F PLA2G2D PLA2G2E CHPT1 GPD1L CDS1 PITPNM1 PITPNM3 PNPLA2 PITPNM2 CDIPT SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC MRE11 NLRC3 IFI16 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions ITGA10 CHL1 ITGA2 ITGA1 ANK1 CNTN6 HSPA8 NRP1 ITGB1 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKAR2A PRKACG PPP3CB AKAP5 PRKACA PRKACB OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF QRFPR HCRTR1 QRFP NPFFR2 HCRT NPFFR1 HCRTR2 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis RXRA NR1H2 NR1H3 RXRB NCOR2 NCOR1 UGT1A3 FABP6 NCOA1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks RAD50 MRE11 KPNA2 ATM KAT5 NBN MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR5AL1 OR8H3 OR8H2 OR8H1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 KCNMA1 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 SLC17A8 OR2A25 OR51I2 ITPR3 TAS2R30 TAS2R31 LRP8 OR10S1 TAS2R38 KCNMB1 OR52K2 OR51I1 TAS2R39 OR52K1 CNGA2 APOB RPE65 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 ATP2B1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 TAS2R50 OR4D1 OR5F1 OR10Z1 NMT1 OR52R1 OR4C6 OR4C5 OR3A3 SPTAN1 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 HSD17B6 OR4C45 OR5AN1 OR4B1 OR4C46 GSN OR8J3 OR6F1 OR8J2 FNTA OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 PRKCQ OR5H14 OR2D3 OR52A4P CYP4V2 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 CALHM1 OR6K2 CALHM3 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 CAPZA2 OR5H6 OR4F5 OR2B3 SDC4 OR4F4 OR2B2 SDC2 OR10K2 SDC3 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 GPC1 OR51A7 OR2A2 GPC3 TAS2R7 GPC2 OR52J3 GPC5 RTP2 GPC4 OR51H1 TAS2R8 GPC6 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 SDC1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 OR51G2 OR51G1 OR52I2 SNAP25 OR52I1 RAB3A OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 DNAJC5 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 MSN OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 CAPZA1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LRP2 AWAT2 GNG13 GNB1 GNB3 GNGT1 RDH5 RLBP1 HSD17B1 CAPZB AKR1C1 TTR AKR1C4 PLB1 SPTBN1 CALM1 RDH11 RDH10 RDH16 AKR1C3 DHRS3 DHRS9 APOA2 APOA1 APOA4 LPL LDLR GPIHBP1 APOC3 TRPM5 TRPM4 MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 GRM1 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B PLCB2 MYO3A FSCN2 EZR TWF2 PCDH15 PDE6B CABP2 PDE6A USH1C CACNA1D CABP1 LRRC52 ESPNL PDE6G EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 LHX2 STX1A SCN1B OTOF SCN3A SCN2A SCN2B PRKCA KCNQ4 SCN9A SCN4B VAMP2 ABCA4 SCNN1G SCNN1D SCNN1B SCNN1A RBP4 RDH12 OPN1LW RBP1 LRAT STRA6 OPN1MW CASK OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 GUCY2D OR2AE1 GUCA1B OR11H6 GUCA1A OR11H7 GUCA1C OR2L8 GUCY2F OR1J4 GRK1 OR2L5 GRK7 OR11G2 FNTB OR1J2 RHO OR2L3 CNGA1 GNAT1 OR4P4 OR1J1 RCVRN OR2L2 CAMKMT OR10AD1 RGS9BP OR6T1 SAG OR4K15 NMT2 RBP3 PPEF1 OR4K14 METAP1 OR4K13 METAP2 OR13J1 CNGB1 OR7A2P CHRNA9 OR2K2 CHRNA10 OR1I1 KCNN2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 GNAT3 OR1L1 OR5T3 HSPG2 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOE OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P EPB41L1 OR5AS1 OR2T8 OR2T7 OR2T6 AGRN OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 APOC2 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 KCNJ2 OPN1SW OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 LRP1 RETSAT OR6C74 OR14I1 APOM OR10A7 OR56A5 BCO2 OR7A5 BCO1 OR10A2 OR56A4 AKR1B10 CLPS OR10A4 RBP2 OR56A3 SLC24A1 OR10A3 LRP10 OR10A6 LRP12 OR56A1 PNLIP OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL SRC YWHAB HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex XIAP SOX17 APC SRY YWHAZ SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 TCF7L2 PYGO1 BCL9 TCF7L1 PYGO2 HDAC1 UBA52 LEF1 TCF7 TLE4 TLE2 TLE1 BTRC RBBP5 CTNNB1 CTBP1 UBB UBC ASH2L RPS27A KMT2B SOX2 AKT2 MEN1 SOX9 TLE3 XPO1 DPY30 WDR5 AKT1 CHD8 CBY1 SOX3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CDK1 CCNB2 CLIP1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN JMJD6 RIOX2 BGLAP EIF5A DHPS FN3KRP EIF5A2 FN3K ICMT DOHH RPL8 STS RWDD1 JMJD4 KDM8 JMJD7 ARSA ETF1 RIOX1 OGFOD1 SUMF2 SUMF1 DRG1 DRG2 RCCD1 ZC3H15 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD F8 RPL27A ARSB ASPH U2AF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 RPS6 DPH6 DPH7 EEF2 F7 F9 PROC F10 TPST2 GGCX PROS1 TPST1 PROZ F2 GAS6 RPS23 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 CD209 BTN3A2 BTNL2 PPL XDH INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals MT1G MT1H MT1X MT4 MT1B MT3 MT1E MT2A MT1A MT1M MT1F GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib SLC37A4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib ERBIN HSP90AA1 ERBB2 CDC37 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 RASGRP2 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A RARRES2 IGF2 RAF1 RAB27B IGF1 PPBP RAPGEF3 CYRIB MANF RAPGEF4 SELP TF SCCPDH CALU MAGED2 PLA2G4A HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 ITPR1 CTSW ITPR2 ORM2 ITPR3 SERPINA4 TMSB4X PSAP ALB PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 TRPC7 ABCC4 AHSG ANXA5 F5 TRPC6 PLCG2 F8 TRPC3 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 CRK LEFTY2 LY6G6F LHFPL2 PCYOX1L CD9 FLNA FN1 F2RL2 F2RL3 LCP2 F2R LAT PRKCB RAC1 VAV3 PRKCQ P2RY12 P2RY1 VAV1 VAV2 MPL THPO ACTN1 GNA13 ADRA2C ADRA2B ADRA2A TBXA2R AKT1 GP1BB PRKCD PRKCA GP5 YWHAZ GP9 LYN PIK3CG PIK3R6 PIK3R5 GP6 CFL1 PF4 SOD1 AAMP MAPK14 PPIA TUBA4A PRKCG PRKCE GNG10 GNG12 GNG11 GNG13 GNB2 CFD GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TGFB1 GNGT2 GNA14 GNG3 GNA15 PDPN MPIG6B GNG2 CLEC1B GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 EGF PIK3CB PFN1 PRKCZ BCAR1 PCDH7 PDPK1 PIK3R3 PIK3CA ITGB3 ITGA2B SOS1 BRPF3 SPARC RAC2 SHC1 SERPINE1 RHOG PIK3R2 PIK3R1 GP1BA RHOA RHOB MAPK1 GNAT3 FCER1G MAPK3 PTPN1 TGFB2 PTPN11 TGFB3 CDC42 MGLL DGKG SRC ACTN2 DGKE DAGLA DGKD DGKB DGKA ABHD6 GNAI3 ABHD12 PRKCH GNAI1 DGKZ DGKQ GNAI2 DAGLB DGKK DGKI DGKH CALM1 CD36 VEGFB VEGFC VEGFD THBS1 VEGFA ALDOA GNA12 CSK FGB FGA VWF FGG APBB1IP TLN1 VCL PTPN6 SYK LCK FYN APP F13A1 POTEKP ISLR LAMP2 HABP4 PROS1 FAM3C CHID1 F2 PTK2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 TREX1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction KCNJ11 ABCC9 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 GUCY1A2 GUCY1A1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MME ATP2B4 NPR1 ATP2B3 NPR2 ATP2B2 NPPC ATP2B1 CORIN TRPC1 CES1 SLC8A3 TTN ANXA1 PXN KCNK6 KCNK7 KCNK1 MYL12B CACNA2D2 MYL6 MYH11 CACNB2 NKX2-5 SCN11A SCN10A TMOD3 SCN1B SCN1A MYL9 KCNH2 SCN3B SCN3A KCNK10 GATA4 KCNK13 SCN2A KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 SCN9A KCNK9 SCN8A CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A ANXA2 KCNA5 SCN4A SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 TRIM72 PAK1 DYSF LMOD1 AHCYL1 MYL6B CACNA1H MYL12A MYLK CACNA1G CACNA1I ALDH2 PAK2 CALD1 ANXA6 MYL10 CAV3 TPM2 MYL11 TPM1 SORBS1 SORBS3 MYL5 MYL7 ITGA1 DMD SLN ATP1B3 ATP1B2 ATP1B1 PDE5A VIM ACTN3 KCNK12 KCNK15 FXYD4 MYL4 FXYD3 MYL1 MYL2 FXYD2 MYL3 DMPK FXYD1 MYBPC3 FXYD7 MYBPC1 FXYD6 MYBPC2 TNNC1 RYR1 TNNC2 RYR2 TNNT1 RYR3 TNNT2 TNNT3 TCAP CLIC2 TMOD1 TMOD4 TMOD2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 MYH3 MYH8 MYH6 ATP1A4 CACNG6 ATP1A3 CACNG7 TNNI1 ATP1A2 TNNI2 TNNI3 ATP1A1 KCNIP1 TPM4 KCNIP2 KCNIP4 TPM3 DES RANGRF PLN KCNIP3 FKBP1B ITGB5 CACNB1 CAMK2B CAMK2D ACTN2 CAMK2A TBX5 CACNG8 CALM1 CAMK2G CACNG4 KCNJ2 KCNJ4 KCNJ12 TLN1 VCL WWTR1 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A TCEA1 ERCC8 DDB1 XPA COPS7B COPS7A CUL4A COPS3 PPIE COPS6 COPS5 COPS8 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication ORC4 ORC6 H2BC9 ORC1 H2AZ2 ORC3 H4C9 ORC2 H2BC8 H2BC5 H2BC3 KPNA1 H2BC1 H2AC20 KPNB1 H2AX H2AB1 H2AC19 KPNA6 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ORC5 H3C15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT SOX17 XIAP SRY RNF146 SOX6 WNT5A SOX7 SOX4 WNT1 BCL9L RUVBL1 CTNNBIP1 FZD1 SOX13 RYK USP8 PYGO1 FZD8 BCL9 PYGO2 TLE4 TLE2 TLE1 CUL3 TNKS SMURF2 USP34 DPY30 WDR5 AXIN2 BTRC RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 KLHL12 LGR6 WNT3 LGR5 CCDC88C RSPO4 DACT1 LGR4 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 EP300 SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 PPP2R5E H3C15 FRAT2 FZD2 FZD5 H2BC9 FZD4 H2AZ2 H4C9 FZD6 PPP2R5B H2BC8 PPP2R5A H2BC5 PPP2R5D H2BC3 PPP2R5C H3-4 TCF7L2 H2BC1 TCF7L1 HDAC1 H2AC20 LEF1 TCF7 PIP5K1B CTNNB1 PPP2CA PPP2CB ASH2L MYC RSPO3 TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 APC YWHAZ PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 CSNK1G2 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 LEO1 WNT3A LRP5 PSMA7 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 KAT5 LRP6 PSMB4 DKK4 SFRP1 CTBP1 PSMB5 CSNK1E SFRP2 UBB WIF1 SOST PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A TERT ADRM1 MEN1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 WNT4 SMARCA4 PSMC1 CSNK2B PSMC2 TLE3 CHD8 CAV1 CBY1 SOX3 TRANSLATION%REACTOME%R-HSA-72766.7 Translation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 APEH HEMK2 MRPS18B MRPS18A ETF1 GSPT2 MRPS21 GSPT1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 TUFM MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 RARS1 EIF2B5 MRPL30 EIF2B4 EIF2B3 MTRES1 LARS1 EIF2B2 MTRFR NDUFAB1 EIF2B1 AIMP1 AIMP2 RPS4Y2 QARS1 RPS27L RPS4Y1 RPS4X MARS1 RPS15 RPS14 DARS1 RPS17 SARS1 EEF1E1 RPS15A RPS16 RPS19 KARS1 RPS18 RPS3 IARS1 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPN2 ASCC2 RPN1 ASCC3 EIF2S2 EIF2S1 DDOST MT-CO1 EIF2S3 EPRS1 EIF4EBP1 EIF4E EIF4B TRMT112 EIF1AX UBE2D2 EIF4H PSMD8 UBE2D3 EIF3M PSMD6 EIF3K MT-CO2 EIF3L PSMD7 MT-CO3 ELOB EIF3I ELOC EIF3J PSMD2 RBX1 EIF3G EIF3H PSMD3 EIF3E CUL2 EIF3F PSMD1 EIF3C EIF3D EIF3A EIF3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 LTN1 NPLOC4 PSMD12 SEC61G PSMD11 RPLP0 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SSR1 PSMC2 EIF4G1 SRPRA SRPRB MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 SEC61A2 SPCS3 SEC61A1 SPCS2 VCP SPCS1 SEC11A SEC11C MT-ATP6 MT-ATP8 MT-ND4L PARS2 EARS2 LARS2 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 EIF4A2 TCF25 SRP54 EIF4A1 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 MT-CYB SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 CARS2 VARS2 ANKZF1 KLHDC10 TSFM RPL4 EIF5B RPL5 MARS2 RPL30 DARS2 RPL3 EEF1G RPL32 SARS2 RPL31 NEMF RPLP1 EEF1D RPL34 MTRF1L RPL10L EEF1A1P5 RPL8 MTIF2 RPL10A MTIF3 RPL6 IARS2 RPL7 WARS1 RPL7A WARS2 RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 SRP14 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBE2D1 SEM1 EEF2 MRPS17 MRPS15 MRPS16 MRPS14 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2B GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 GRIA3 CAMK2G GRIA4 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO2 SLIT1 NCK2 ROBO1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism PLCB4 MTMR9 INPP5D MTMR7 PLCG1 PLD4 IPPK ISYNA1 IPMK OCRL INPP1 IP6K1 NUDT3 IP6K2 NUDT4 INPP5B SYNJ1 NUDT11 NUDT10 INPP5A IMPA1 PPIP5K1 PLCZ1 IMPA2 INPP4A PPIP5K2 INPP5J PLCE1 INPP4B IP6K3 MIOX ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers JUN SEL1L FZD8 ERLIN2 NPM1 KLC1 MAMLD1 IHH DERL2 TRAK1 ERLEC1 OS9 KIF5B PRR5 GSK3A EML4 KRAS MAML2 MAML1 FGFR2 JUNB RAC1 MAML3 VAV1 MAPKAP1 DUSP6 DUSP7 GZMB DCTN1 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 MAPK8 BCL2L11 PAPSS1 BAD CD19 SQSTM1 AGK RBX1 POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F PIK3CG POLR2G POLR2H PIK3R6 POLR2I PIK3R5 POLR2J POLR2K POLR2L WDR48 GTF2F1 GTF2F2 IL10 PTPN12 MSN TYK2 KAT2B PIK3CD KAT2A ALK LMNA TP53 VCP TNKS FOXO4 FOXM1 CDK8 SMAD2 SMAD4 SMAD3 ESR1 JAG2 ADAM17 MDM2 ZMYM2 PTEN ARRB1 ARRB2 TPR HDAC5 RANBP2 FGFR3 HDAC8 HDAC9 HDAC6 HDAC7 TPM4 RNF43 TPM3 KLB FLT3 IRS1 PPP1CC PPP2R1B IRS2 PPP2R1A PIK3CB TNKS2 PPM1B FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 HDAC10 FGF9 HDAC11 AKT2 HRAS PDPK1 GAB1 FLT3LG TWIST1 FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 CARS1 PIK3R1 NRAS FGF20 PPFIBP1 MAPK1 EEF1G FGF23 CHUK FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 SNW1 CAMK2B ESR2 CAMK2D SRC NR4A1 CAMK2A NRG1 TFG MPRIP FGFR1OP2 ZAP70 SND1 ZC3HAV1 EIF2AK3 NOX4 CALM1 ATIC CAMK2G DUSP8 DUSP9 MRAS FAM114A2 KDR PORCN MCL1 CD86 QKI CD80 NF1 KIAA1549 ERBB2 DUSP10 CCNB1 HES1 ESRP1 TRAT1 BIRC6 RPS6KB2 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 PHB1 AGTRAP ARAF AP3B1 SHOC2 PEBP1 CSK AGGF1 JAK2 CPSF6 MARK3 TENT4A SPRED3 FGB BRAP SPRED2 SPRED1 FGA VWF MYO18A KSR1 LRRFIP1 KANK1 PPP1CB FGG RRBP1 BRAF ETV6 WDCP KSR2 GOLGA4 FAM131B BIN2 CNKSR2 STRN APBB1IP CNKSR1 NCBP1 TLN1 NCBP2 VCL FRS3 JAG1 LCK SEM1 IRF4 DLL1 FYN BCL2A1 SKP1 HGF CLIP1 CUL1 CLTC GCC2 NTRK3 NTF3 PDGFB NEURL1B HES5 MIB2 RAP1B MIB1 HEYL RAP1A NEURL1 RAF1 PRF1 ICOS STAT5A IL10RA ZC3HC1 FIP1L1 FN1 CUX1 TRIP11 RPS6 PDGFRA PRKAR1A MYH9 KIT NOTCH1 FZD5 FZD4 HBEGF FZD6 TCF7L2 CDKN1A HDAC1 CTNNB1 MET CEBPB RNF213 ATG7 SEC31A RBPJ TNRC6C MOV10 MLST8 AGO3 AGO4 MYC AGO1 AGO2 TSC2 PIM1 MTOR YWHAB FKBP1A PSMD8 PSMD6 PSMD7 PSMD2 AKT1S1 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 PSMB5 UBB BCR PSMB2 PSMB3 LMO7 UBC PSMB1 RPS27A AKAP9 HEY1 HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CASP9 ERBIN CEP43 KDM7A TGFB1 RICTOR TGFBR1 TGFBR2 STAT1 CD28 IQGAP1 HSP90AA1 EGF CBL EGFR CDC37 PLCG1 RB1 CDKN1B MAP3K11 DUSP16 FGFR1 CLCN6 FOXO6 FOXO1 EP300 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 ITGA2B NRG2 STAT3 HDAC3 TBL1X NCOR2 NCOR1 TBL1XR1 HDAC4 HDAC2 PIK3AP1 AMER1 GSK3B CSNK1A1 AXIN1 APC STAT5B CCNC GRB2 HHAT SHH DHH CTBP2 CTBP1 DNMT1 CREBBP AREG BCL2L1 PTPN6 MAPK9 YES1 NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 EREG SYVN1 BTC EPGN AKT3 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP PPHLN1 H2AC20 MPHOSPH8 H2AX ZCCHC8 EHMT2 EHMT1 H2AB1 TASOR MTREX H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B RBM7 H3C8 MORC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SETDB1 H3C15 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK10 MAPK8 FOS MAPK3 MAPK9 MAPK14 ATF2 MAPK11 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 ALOX5 LTA4H DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 NEIL1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 C2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress GNG13 ITGA5 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 PIK3R2 GNB3 ADCY4 NFKB1 ADCY3 GNB5 ADCY2 ADCY1 ABL1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB CHUK STAT1 PTPN1 IKBKB PPP2CA PECAM1 MLST8 GNG3 GNG2 GNG5 NFKBIA GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 IKBKE AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 IKBKG PPP2R1B ANXA2 PPP2R1A PIK3CB CALCRL ADM TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PTK2 PIK3CA P2RY2 ITGB3 ITGB1 MMP14 GNG12 ITGAV MAPKAP1 GNG11 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor F8 VWF MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2A POLR2B BCDIN3D POLR2C XPO5 POLR2D AGO3 PRKRA POLR2E DROSHA RAN DICER1 AGO4 POLR2F TARBP2 POLR2G POLR2H AGO1 POLR2I AGO2 POLR2J POLR2K POLR2L DGCR8 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly HSP90AA1 IPO5 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis RXRA CYCS SAMM50 HDAC3 MTX1 APOOL NR1D1 CHCHD3 DMAC2L TBL1X NCOA1 ESRRA PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 MT-ATP6 PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 MAPK12 HCFC1 CALM1 ATP5PF ATP5PD PPARGC1A ATP5PB NCOA2 PPARGC1B ATP5F1C NCOA6 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 NRF1 ATP5PO GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HSPA9 HELZ2 ATP5MC2 CREBBP CHD9 ATP5MC3 ALAS1 ATP5MK ATP5MJ MICOS13 MICOS10 CHCHD6 MTERF1 ATP5MG MAPK14 GABPA MED1 MAPK11 SIRT5 TGS1 ATP5MF PPRC1 MEF2D ATP5ME PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 ATP5F1A IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 MTX2 PPARA ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion PRKCA CHRM3 GNA14 GNAQ MARCKS GNA15 PLCB3 PLCB1 PLCB2 GNA11 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors MEF2C RBFOX1 PPARG RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 H2BC15 TP53 H2BC11 ATM UBE2N MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase SHQ1 ACD DKC1 TINF2 TERF1 RUVBL2 TERF2 RUVBL1 TERT NHP2 ANKRD28 POT1 NOP10 TERF2IP WRAP53 PPP6C PPP6R3 RTEL1 CDK2 CCNA2 CCNA1 PIF1 GAR1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RIPK1 CASP10 MAVS FADD RNF135 RIGI CHUK IFIH1 CASP8 TRIM25 TRIM4 IKBKG CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions CDH24 CTNNB1 CDH11 JUP CTNND1 CDH8 CTNNA1 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 FCN1 MASP1 FCN2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway TALDO1 PGD DERA TKT RPIA PRPS2 PRPS1 RPEL1 RPE SHPK PGLS PRPS1L1 RBKS G6PD PGM2 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 FLRT1 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 GIPC1 ANOS1 MAPK1 FLRT3 FGF23 FGF22 SPRED2 SPRED1 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FRS3 FGF3 RPS27A FGF4 FGF6 FGF9 TGFBR3 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 SEL1L PSMA3 CFTR PSMA4 PSMA1 PSMA2 ERLIN1 ERLIN2 UBA52 PSMD12 PSMD11 RNF185 PSMD14 PSMD13 PSMA7 PSMB6 VCP PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 DERL3 DERL1 UBC DERL2 PSMB1 RNF5 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein PRMT1 UBE2I SRPK1 SUMO1 PARP10 SRPK2 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 CSNK1A1 PARP14 PARP8 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB RIPK1 UBC TICAM2 UBE2D1 TICAM1 RPS27A UBE2V1 LY96 TRAF6 UBA52 BIRC2 CD14 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB TLR4 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON GRK2 IHH ARRB1 SHH DHH ARRB2 SMO KIF3A CSNK1A1 PTCH1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress COX5B COX5A RELA NUDT2 PRDX3 NOX5 NQO1 GSTA3 COX6C GSTA1 ERO1A SESN1 SRXN1 CHD6 GPX3 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB COX6A1 BLVRA CCL2 ABCF2 COX6A2 TXNRD2 SOD3 CCS G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM ALB P4HB AQP8 CAT BTRC SOD2 CARM1 ATOX1 FBXL17 BACH1 PRKCI SLC7A11 MED1 NOTCH1 PRDX2 PRDX1 PTK6 CDKN1A CDKN2A SIN3A PRKAA2 MT-CO1 SQSTM1 ATF4 TKT MYC PSMD8 KEAP1 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 PSMD2 RBX1 PSMD3 AKT1 PSMD1 IDH1 PRKCD NCF1 PSMA5 NCF2 PSMA6 NCF4 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 NPLOC4 PSMD12 PSMD11 UBXN7 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CYBB PSMB4 CYBA DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 TALDO1 UBC PSMB1 RPS27A SOD1 ADRM1 CSNK2A1 PSMC5 GPX1 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PPARA CYCS MAFG PGD MUL1 CUL3 VCP PRDX6 NLRP3 TRIM21 GSTP1 HBA2 SESN2 HMOX2 GPX2 MAP1LC3B EGF SMARCD3 SKP2 TXNRD1 EP300 AKT2 STAP2 COX7A2L TXN RXRA STAT3 NFKB1 ABCG2 HBB HDAC3 COX4I1 COX4I2 TBL1X NCOA1 FABP1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 ABCC3 ABCC1 HM13 EIF2AK3 AMER1 NOX4 GSK3B NCOA2 NCOA6 ME1 TXN2 BRCA1 HELZ2 CREBBP SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 PALB2 TGS1 SEM1 COX7B SKP1 COX7C COX8A COX8C CUL1 AKT3 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 BCL11B SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 PHF10 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 BICRAL BRD7 BICRA BRD9 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 DPF1 HDAC2 DPF2 KAT8 DPF3 KDM5B SUZ12 KAT14 SETDB1 SS18L1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SS18 SMARCB1 BCL11A AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 KDM6A DNMT3A PBRM1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 AP2M1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA CSTF2T CLP1 ZNF473 SNRPD3 FIP1L1 SNRPB PABPN1 CPSF4 SLBP CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 CSTF2 CPSF2 CSTF1 PAPOLA SYMPK LSM10 NCBP1 LSM11 NCBP2 PCF11 SNRPG WDR33 SNRPE SNRPF TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR GCHFR GCH1 SPR NOS3 PTS HSP90AA1 PRKG2 AKT1 CALM1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion FES PLXNA2 PLXNA3 HSP90AA1 HSP90AB1 PAK1 PAK3 LIMK1 RAC1 FYN CFL1 PLXNA4 PAK2 NRP1 PLXNA1 SEMA3A CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAH YWHAZ WEE1 SFN CCNB1 CDC25C CDK1 YWHAB CHEK2 YWHAE CCNA2 CCNA1 YWHAQ CHEK1 YWHAG TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN TIMP1 NCSTN APH1B PSEN2 TIMP2 PSEN1 TGFBR3 APH1A MMP14 MMP16 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP5 GP9 VWF GP1BA GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 FABP6 MGLL PLIN1 PPP1CA ABHD5 FABP12 PRKACG PRKACA LIPE PRKACB FABP9 PPP1CB FABP1 PPP1CC CAV1 FABP2 FABP3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling IL21R JAK3 STAT5A STAT5B STAT4 STAT3 JAK1 STAT1 IL2RG IL21 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine CBS CTH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly PET100 COX5B COX5A COA5 CMC1 SCO1 COX6C TACO1 SMIM20 COX4I1 COX4I2 SURF1 COX6A1 COX6A2 COX16 TIMM21 COX15 MT-CO1 COX18 COX6B2 HIGD1A COX6B1 COXFA4 COX7A2 COX7A1 COX11 COX19 COX17 COX14 RAB5IF COQ10B COQ10A TMEM177 COA3 SCO2 COA1 COX7A2L MT-CO2 COX7B MT-CO3 COX7C HIGD2A PET117 COX8A COX20 COX8C TMEM223 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM RTEL1 MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PIK3R1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 CD19 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CD22 TRPC1 IGKV2D-40 PIK3AP1 IGHV3-11 IGHV3-13 IGLV7-43 CALM1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 BTK IGLC3 BLNK IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 PIK3CD IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PTPN6 SYK AHCYL1 FYN VAV1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB P4HA1 P4HA2 P4HA3 COL1A1 COL1A2 ADAMTS14 P3H2 P3H1 P3H3 SERPINH1 COL3A1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC9 H2AZ2 H4C9 H2BC8 NCOA2 H2BC5 H2BC3 H2BC1 H2AC20 PKN1 KDM1A H2AX KLK3 KLK2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B KDM4C H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 AR KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling CASP10 FAS CASP8 FASLG FADD SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins DNMT1 BMI1 RING1 UBE2I SUMO1 RNF2 DNMT3B CBX8 PHC2 PHC1 DNMT3A CBX4 PCGF2 CBX2 PHC3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FRS2 KLB PTPN11 FGF16 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus CLP1 POP5 POP7 POP1 RPP30 POP4 RTCB CPSF4 TSEN2 TSEN54 CPSF1 RPP38 CSTF2 RPP21 RPP25 DDX1 C2orf49 RPP40 TSEN15 ZBTB8OS TSEN34 NUP205 POM121 RPP14 NUP107 NUP188 RTRAF AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 XPOT NUP88 FAM98B NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ELAC2 TRNT1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) UBC DERL2 SEL1L RNF5 RPS27A OS9 MAN1B1 UBA52 RNF185 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 EDEM2 AMFR SYVN1 RNF103 UBB TRIM13 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1 OXCT2 ACAT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis GPI ENO1 ENO2 ENO3 ENO4 G6PC1 TPI1 PGAM1 PC PGAM2 ALDOC ALDOB ALDOA GAPDH PCK2 PGK1 SLC37A1 PGK2 G6PC2 PCK1 G6PC3 FBP1 FBP2 SLC37A4 GAPDHS CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SESN1 SESN2 SEC13 RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X RPS15 SAMTOR RPS14 SEH1L RPS17 NPRL2 NPRL3 RPS15A RPS16 GCN1 TCIRG1 RPS19 WDR59 RPS18 EIF2AK4 FLCN RPS3 MIOS RPS2 RPS11 ITFG2 IMPACT RPS10 DEPDC5 RPS13 KPTN RPS12 WDR24 RPS9 SH3BP4 RPS7 FNIP1 ATP6V1E1 RPS8 FNIP2 RPS5 KICS2 ATP6V1E2 RPS6 CASTOR1 RPSA CASTOR2 ATP6V1G1 RPS3A RPS26 ATP6V0B ATP6V0E1 ATP6V1G2 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ATP6V1B2 TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A RPL4 RPL5 ATP6V1H RPL30 RPL3 RPL32 ATP6V0E2 RPL31 ATP6V1G3 RPLP1 RPL34 ATP6V1D RPL10L RPL8 ATP6V1C1 RPL10A ATP6V1F CEBPB RPL6 ATP6V1C2 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPTOR RPL37 ATF3 ATF4 RPL39 RPL21 MLST8 RPL23 SLC38A9 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 MTOR RPL10 RPL12 RRAGA RPL11 RRAGC RPL36A RPL14 RHEB RPL13 RRAGB RPL15 RRAGD RPL18 RPL17 RPL19 LAMTOR2 RPL39L LAMTOR1 RPL41 LAMTOR4 RPL35A LAMTOR3 RPL23A LAMTOR5 RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism CHST2 B4GALT4 CHST3 B3GNT3 GNS ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 GALNS FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 HEXB HEXA B4GALT2 GLB1L3 B4GALT3 PRELP GLB1L2 CHST6 OMD KERA GLB1L B3GNT7 GLB1 B3GNT4 OGN CHST1 B3GNT2 CHST5 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway XIAP RACK1 TRAF1 TRAF2 MAP3K7 USP4 BIRC2 USP2 BIRC3 CYLD RBCK1 OTUD7B CHUK IKBKG IKBKB RIPK1 USP21 SHARPIN TNF OPTN TAB1 TRADD TAB3 TNFAIP3 TAB2 RNF31 SPATA2 TNFRSF1A OTUD1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 TGFB1 CCL11 CCL2 STAT1 VCAM1 VIM CCL22 BCL6 IL6 TIMP1 RORC RORA NOS2 POU2F1 IL17F IL17A ANXA1 LBP LAMA5 HSP90AA1 FN1 S1PR1 JAK3 IL18 IL1A ITGAM IL1B ITGB2 LCN2 MMP1 MMP2 FGF2 TNFRSF1B FOXO1 IL6R JUNB SOCS3 SOX2 MAOA MMP3 TWIST1 HSP90B1 ITGB1 IL23R IL13RA2 IGHG4 IL13RA1 IGHG1 IL4R STAT3 IL23A FSCN1 PIK3R1 CDKN1A NDN LIF RHOU NANOG ALOX15 IGHE ITGAX OPRD1 OSM BATF CCND1 BIRC5 FASLG SOCS1 FCER2 MYC PTGS2 PIM1 ALOX5 HMOX1 AKT1 HIF1A OPRM1 CD36 MCL1 GATA3 VEGFA POMC COL1A2 IL4 JAK2 MUC1 IL12B IL12A IL13 JAK1 IL2RG IL10 MMP9 SOCS5 BCL2 TYK2 TNF BCL2L1 HSPA8 ICAM1 ZEB1 CEBPD IRF4 STAT6 F13A1 SAA1 TP53 FOS FOXO3 HGF SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN NTRK1 RIT1 NGF RIT2 BRAF VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis NUP85 TPR NUP62 POLR2A POLR2B NUP88 POLR2C NUP43 POLR2D RAE1 POLR2E POLR2F NDC1 POLR2G RANBP2 POLR2H SEC13 POLR2I NUP155 POLR2J NUP133 POLR2K NUP210 POLR2L NUP153 NUP93 NUP50 NUP35 NUP54 GTF2F1 GTF2F2 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids GGPS1 CYP51A1 SRD5A3 LSS SREBF2 SQLE MTF1 DHCR7 SLCO1B1 SLCO1B3 LDLRAP1 CUBN ACACB GPAM STS SLC51A SLC51B CYP27A1 SAR1B CYP39A1 PLPP6 LHB ABCB11 SEC23A MBTPS1 SCAP VDR ALB SLC10A1 MBTPS2 SLC10A2 STAR AKR1B15 SEC24B SEC24A AKR1B1 ARV1 CYP17A1 SMARCD3 STARD3NL SEC24D CYP7B1 SEC24C AKR1D1 CARM1 KPNB1 HSD17B7 CYP7A1 HSD17B1 HSD17B2 HSD17B3 HSD17B12 AKR1C1 NSDHL AKR1C2 ACACA FDXR MED1 AKR1C4 STARD3 STARD4 CYP8B1 STARD5 STARD6 MSMO1 CH25H CYP46A1 FDX1 ELOVL6 FDX2 RXRA SCD FASN CGA SLC27A2 HSD11B1 HSD11B2 IDI2 NFYA EBP NFYB CYP11A1 NFYC TBL1X LGMN NCOA1 ACOT8 CYP11B2 SERPINA6 CYP27B1 TSPO CYP24A1 CYP2R1 CYP21A2 TBL1XR1 FABP6 SUMO2 ABCC3 UBE2I GC NR1H4 HSD3B7 OSBP HSD3B2 PIAS4 HSD3B1 AMACR NCOA2 SLC27A5 NCOA6 RAN INSIG2 INSIG1 CYP19A1 POMC ACAT2 MVD OSBPL9 LBR OSBPL7 OSBPL6 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 BAAT HELZ2 ACOX2 CREBBP CYP11B1 SLCO1A2 SP1 CHD9 OSBPL1A TGS1 AKR1C3 HSD17B4 HSD17B14 IDI1 LRP2 MVK TM7SF2 HSD17B11 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 PPARA TSPOAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer APC FZD5 FZD4 PORCN FZD6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 FZD8 WNT3A LRP5 RNF43 KREMEN1 CTNNB1 KREMEN2 DKK1 TNKS DKK2 LRP6 CTBP2 DKK4 CTBP1 PPP2R1B PPP2R1A TNKS2 PPP2CA PPP2CB AMER1 GSK3B CSNK1A1 PPP2R5E AXIN1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation CYB5B HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NMT2 AKT1 ZDHHC21 CALM1 CAV1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation HBEGF SH3KBP1 EGF ARHGEF7 CBL EGFR UBA52 STAM STAM2 HGS PTPRK EPS15L1 PTPN12 EPN1 UBB SPRY1 PTPN3 CDC42 UBC RPS27A SH3GL3 AREG EPS15 SH3GL2 SH3GL1 SPRY2 TGFA EREG BTC EPGN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis MT-ND6 MT-ND4 NDUFC2 MT-ND5 NDUFC1 MT-ND2 MT-ND3 NDUFS8 MT-ND1 NDUFS7 NDUFS6 PYURF NDUFS5 NDUFS4 NDUFS2 TMEM126A NDUFS1 TMEM126B NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFAF8 FOXRED1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFA9 NDUFA8 NDUFAF2 NDUFA7 SFXN4 NDUFA6 NDUFAF3 NDUFAF1 NDUFA3 NDUFA2 NDUFA1 TMEM186 ACAD9 OXA1L DMAC1 DMAC2 NDUFS3 TIMMDC1 NUBPL LYRM2 HSCB NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 ECSIT NDUFB10 HSPA9 NDUFB11 NDUFV3 NDUFV2 NDUFB8 NDUFV1 COA1 NDUFA5 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling SLC25A14 UCP1 SLC25A4 PM20D1 UCP3 SLC25A27 UCP2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer SKP1 RBX1 NOTCH1 CUL1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TIAM1 ERBIN ARHGAP26 MPP7 VANGL1 RAC2 ARHGAP32 ABI2 TAOK3 PIK3R2 PIK3R1 ABI1 ESYT1 SAMM50 MTX1 ABR MCF2 PLD2 CDC42 DOCK4 ANKLE2 DOCK3 ARHGDIA LAMTOR1 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 IQGAP1 TFRC NCF2 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 EMD LBR GIT1 TMPO SWAP70 ARMCX3 CYBB CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 DSG2 VAMP3 RAB7A CDC42EP4 EPHA2 GARRE1 TRIO ARHGAP17 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 VAV3 NHS SLITRK5 DEF6 VAPB NCKAP1L PAK2 WASF2 PIK3CA PIK3R3 PAK4 DIAPH3 ITGB1 VAV1 GIT2 VAV2 CAV1 MCAM TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 INS PLK2 NPAS4 MAPK1 ARNT2 REST BMAL1 SRF NR3C1 MAPK3 CDK5R1 RET KCNIP3 CREBBP GEM ARNT TNRC6C MOV10 NAMPT CDK5 AGO3 AGO4 RBFOX3 AGO1 AGO2 MDM2 TNRC6A TNRC6B IQSEC3 BDNF XPO1 FOS SYT10 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B GALNT12 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 SULT1C4 SULT2A1 SULT1A3 TPST2 TPST1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression JUN ZNF217 EBAG9 KDM4B YY1 DDX5 GPAM CXCL12 ESR1 POU2F1 TBP HSP90AA1 CARM1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 H3-3B H3C8 MED1 H2AC8 H2AC6 CTSD H2AC7 H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 HSP90AB1 KDM1A CCND1 PTGES3 NRIP1 FKBP4 NCOA1 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 KANK1 CREBBP SP1 BCL2 CDK9 KAT2B FOXA1 TLE3 KPNA2 TGFA USF1 FOS GREB1 CHD1 PGR TFF3 TFF1 CXXC5 USF2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation BANF1 XRCC6 XRCC4 XRCC5 LIG4 PSIP1 HMGA1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PARS2 YARS2 KARS1 EARS2 LARS2 PPA2 NARS2 RARS2 TARS2 AARS2 CARS2 VARS2 HARS2 MARS2 DARS2 SARS2 FARS2 IARS2 QARS1 WARS2 GARS1 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 MET STAT3 HGF VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 STAT5A STAT5B BCL2L1 CDKN1A PIK3R1 GRB2 NRAS PIM1 HRAS GAB2 PIK3CA FLT3 NOX4 PTPN11 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion ALPI MGAM PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B SI AMY1C CLPS LCT GUCA2B CEL GUCA2A CHIT1 LIPF PNLIP PIR PNLIPRP3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production KIF28P IFNA2 IFNA8 MAFG IFNA13 IFNA14 IFNA16 IFNA17 KIF5C ABL1 MFN1 KIF21A MFN2 KIF21B KIFAP3 KLC1 KLC4 IFNA10 KLC3 KLC2 PRKACG IFNA21 PRKACA IFNB1 PRKACB KIF16B KIF3A KIF20B WEE1 KIF3B KIF3C KIF5B CDK5 KIF5A KIF18B KIF4B KIF4A KIF12 PHF21A KIF11 DOCK11 KIF15 KIF19 KIF13B VPS45 KIF1C KIF1B KIF1A KIF25 KIF22 RCOR1 KIF6 KIF27 SH2B2 KIF9 KIFC2 KIFC1 HMG20B DOCK6 DOCK9 CABLES1 DOCK8 DOCK7 RAB5A CAPZB MYB KIF26A KIF26B GATA6 H3-3B H3C8 PRKAR1B PRKAR2B KIF23 PRKAR1A RAC1 PRKAR2A ZFPM1 RBSN KIF20A KIF18A GATA2 H3C15 IRF1 IRF2 NFE2 HDAC1 HBB KDM1A KIF2A SIN3A CDK2 KIF2C KIF2B CAPZA2 CDC42 ITPK1 DOCK5 HDAC2 CENPE DOCK4 DOCK3 CBX5 SH2B3 GATA4 JMJD1C HBE1 GATA1 DOCK2 ZFPM2 DOCK1 GATA5 AK3 MICAL1 CARMIL1 HBG2 GATA3 HBG1 EHD1 EHD2 EHD3 MAFF HBD DOCK10 AKAP10 AKAP1 SH2B1 CABLES2 JAK2 MAFK CAPZA1 RAD51B RACGAP1 RAD51C TP53 IFNA5 IFNA4 IFNA7 IFNA6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism MAN2C1 MANBA MAN2B1 MAN2B2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease FGF18 SOS1 FGF1 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGFR3 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA FGF16 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis GP5 GP9 SERPING1 KLKB1 GP1BA ADAMTS13 F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 MAPK1 FST FOXH1 ACVR1B FSTL3 ACVR2B ACVR2A INHBB DRAP1 INHBA ACVR1C INHA MAPK3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs YAP1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ABL1 H2AC20 ITCH LMO1 LMO2 PSMD8 PSMD6 TCF3 PSMD7 TCF12 LDB1 PSMD2 PSMD3 PSMD1 GATA1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 GATA3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CDK7 PSMB4 MNAT1 PSMB5 H2AX UBB PSMB2 SPI1 PSMB3 H2AB1 UBC H2AC19 PSMB1 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 MYB H3-3B ADRM1 H3C8 H2AC8 H2AC6 PSMC5 H2AC7 PSMC6 H2BC17 SEM1 PSMC3 RUNX1 PSMC4 H2BC12 PSMC1 H2BC13 PSMC2 H2BC14 TP73 H2AJ H2BC15 TAL1 H2BC11 KMT2A CBFB GATA2 H3C15 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1D HTR1A HTR7 HTR1B HTR5A HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NTRK1 SOS1 MAPKAPK3 SHC1 NGF MAPKAPK2 NRAS MAPK14 MAPK11 RALA SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A13 SLC25A18 SLC17A8 SLC6A1 SLC6A5 SLC22A2 SLC22A1 SLC6A4 SLC6A7 SLC6A19 SLC6A2 SLC6A15 SLC6A11 SLC6A3 SLC6A14 SLC6A9 SLC17A6 SLC6A20 SLC17A7 SLC25A22 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR CYP11A1 FDX1 FDX2 FDXR RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 BCL2L11 FOXO3 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation TLL2 TLL1 LAMB3 COL7A1 LAMA3 LAMC2 BMP1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L POLI UBB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC14A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 CDC20 ANAPC15 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF28P KDELR1 KDELR3 SURF4 KIF5C KIF21A KIF21B KIFAP3 KLC1 KIF2A KLC4 KLC3 KLC2 NSF KIF2C KIF2B RINT1 ARF3 KIF16B KDELR2 KIF3A KIF20B COPB2 COPA TMED10 SEC22B KIF3B TMED2 KIF3C KIF5B KIF5A KIF18B KIF4B KIF4A COPE KIF12 CENPE ARF4 KIF11 USE1 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 COPB1 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 ARF1 ARF5 NAPA GBF1 NAPB NBAS RAB1A STX18 RAB1B NAPG BNIP1 ARFGAP3 ARFGAP2 ARCN1 ZW10 KIF26A KIF26B COPG2 COPG1 KIF23 RACGAP1 KIF20A KIF18A ARFGAP1 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 RBBP4 DAXX NUP37 RBBP7 PML H2AC19 DYNC1LI1 H2BC26 H2AC14 DYNC1LI2 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 H2BC17 CHMP2B VPS4A CHMP2A H2BC12 MVB12B H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 ITGB1 H3C15 H2BC9 H4C9 CHMP3 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 HNRNPK SUZ12 H2AC17 H2AC12 NUP214 TRIM28 H2AC25 H2AC21 EZH2 VPS36 VPS25 CBX1 SNF8 CHMP1A CEBPD ELK1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 ESR1 CBFB RSPO3 FOXP3 AXIN1 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX PRDM1 RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM PNP ITPA NT5E NT5C NT5C1A XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades JUN PDGFB RASGRP1 RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB PRKG2 IL2 IL3 IL6 CDC14A FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA RAC1 KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 KALRN DNAJB1 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB SHC2 HSPB1 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 XPO1 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PAK1 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP SEPTIN7 PAK2 CDC14B ARL2 RAG2 RAG1 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A ETV4 RASA3 RASA4 RASA2 ABHD17C IGF2BP1 MAPK6 MAPK4 ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR CCND3 FNTB MAP3K11 MAPKAPK5 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 CDC42EP5 FGF3 CDC42EP3 FGF4 CDC42EP2 FGF6 FOXO1 FGF7 FGF9 IL6R RASA1 PAK3 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 CDC42 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 NCOA3 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA FOXO3 PTK2 HGF EREG BTC EPGN UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases USP17L1 RNF146 TOMM20 RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 USP3 IL33 USP2 MUL1 H2AC1 TGFBR1 CDC25A FKBP8 STAM2 TNKS ADRB2 FOXO4 ATXN7 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 NFKBIA TADA3 MDM2 MDM4 TAB1 RIGI USP37 USP33 USP34 PTEN ARRB1 ARRB2 POLB USP30 USP47 USP48 USP49 USP42 USP44 TRAF2 AXIN2 H2BC18 TRAF6 BIRC2 OTUB1 BIRC3 USP13 USP14 BECN1 USP15 USP16 SKP2 USP10 USP12 HGS MAT2B CDC20 USP18 USP19 TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 PSMD1 USP17L30 HIF1A RNF123 AR AXIN1 RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 PSMA1 SNX3 RHOT1 PSMA2 RCE1 UBA52 SIAH2 PSMD12 PSMD11 TADA2B CYLD PSMD14 H2AC25 H2AC21 PSMD13 WDR48 PSMA7 PSMB6 IFIH1 PSMB7 PSMB4 UFD1 PSMB5 IKBKG UBB TOMM70 PSMB2 PSMB3 UBC PSMB1 DDB2 RPS27A KAT2A PTRH2 WDR20 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 PSMC6 SEM1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 PSMC2 USP17L18 USP17L17 TP53 CCNA2 USP9X CCNA1 USP17L19 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 POU5F1 NANOG INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNG13 GNB2 KCNJ2 KCNJ8 KCNJ3 KCNJ11 GNB1 KCNJ4 ABCC8 ABCC9 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 KCNJ1 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression PTK6 PELP1 EPAS1 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism GUSB CD44 ABCC5 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HAS1 HYAL2 HEXB HAS3 HEXA CHP1 HAS2 SPAM1 HYAL1 HYAL3 HYAL4 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud ROBO2 GFRA1 EYA1 BMP4 SLIT2 FOXC2 ITGA8 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 WNT11 ITGB1 GREM1 SALL1 SIX2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism FOLH1 FOLH1B GOT1 ASPG NAALAD2 NAT8L ASPA SLC25A12 GOT2 ASNS SLC25A13 GADL1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX2 HSD17B4 AMACR ACOX3 ACOXL CROT CRAT ACOT8 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism SLC26A2 CSPG4 CHST3 CHST14 HSPG2 PAPSS2 SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B3GALT6 B4GALT1 B4GALT7 GPC1 GPC3 GPC2 ST3GAL3 GPC5 GPC4 NCAN GPC6 HEXB CHSY1 HEXA BGN DCN PRELP CHST6 BCAN OMD EXT1 VCAN KERA SDC1 OGN CSPG5 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A4 TOMT BCHE SLC6A3 ALDH2 COMT ACHE SLC22A2 SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 GORASP2 GORASP1 USO1 CCNB1 RAB2A CDK1 MAPK1 RAB1A RAB1B GOLGA2 CCNB2 BLZF1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 EPHX2 ALOX5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 NRAS PRKCZ SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 DDX5 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ ACE2 VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 HAVCR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 PARP10 PARP6 SFTPD IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C RPS10 STAT2 CHMP4B RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CHMP2B RPS3A RPS26 CHMP2A RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N CHMP3 CHMP6 HLA-H CHMP7 RPN2 HLA-B ZDHHC20 HLA-C TUSC3 ATG14 PRKCSH HLA-F RPN1 ZDHHC5 HLA-G HSP90AB1 HLA-E MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 SDC2 DDOST SDC3 MGAT4C ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 GPC5 SUMO1 GPC4 YWHAB GPC6 TRIM25 SDC1 IKBKE AKT1 IRF7 VHL NUP214 SFN YWHAZ ISCU UBA52 IFIH1 JAK1 TRIM4 IKBKG TOMM70 UBB RIPK2 UBC TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 FURIN VCP STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C ANO8 ANO9 NUP42 NUP85 ANO6 ANO7 TPR ANO4 NUP62 ANO5 UVRAG NUP88 MAP1LC3B ANO2 ANO3 NUP43 RAE1 HSP90AA1 ANO1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 TMPRSS2 NOD1 SRPK2 ANO10 GALNT1 NOD2 AKT2 PDPK1 NRP1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 PRMT1 SRPK1 HSPG2 TJP1 CHUK PTPN11 AGRN ST6GALNAC2 SIKE1 GSK3B ST6GAL1 CSNK1A1 ST6GALNAC3 ST6GALNAC4 CREBBP ST3GAL4 ST3GAL1 ZCRB1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 SNRPG TAB3 TAB2 SNRPE CTSL IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors JUN ZNF217 EBAG9 DDX5 RXRG GPAM CXCL12 POU2F1 NOS3 TBP S1PR3 CARM1 MMP2 MED1 GTF2A1 GTF2A2 MMP3 SCD FASN HBEGF HDAC1 HSP90AB1 PTGES3 CCND1 FKBP4 ATF2 RARG JUND CYP26A1 CYP26B1 TNRC6C MOV10 CYP26C1 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B XPO1 RARB AKT1 POLR2A POLR2B GATA3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 KAT2B KPNA2 GNG10 IGF1R PGR GNG12 CAV1 GNG11 GNG13 FKBP5 GNB2 PPARD KDM4B YY1 GNB1 DHRS4 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNG3 ESR1 GNG2 GNG5 RDH5 GNG4 GNG7 GNG8 HSP90AA1 EGF EGFR CDKN1B H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 PRKCZ H2AC8 CTSD H2AC6 H2AC7 HRAS H2BC17 RUNX1 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 RARA PIK3R3 PIK3CA CBFB H3C15 RXRA CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 NRAS H2AC20 CETP KDM3A HDAC3 KDM1A MAPK1 GNAT3 KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 SRF ABCA1 MAPK3 ABCG8 KDM4A MYLIP ABCG5 NR1H2 FABP5 KCTD6 APOC4 NR1H3 NCOR2 ARL4C EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ESR2 ABCG1 SRC PDK4 GNAI3 GNAI1 GNAI2 CALM1 AXIN1 NCOA2 NCOA3 PDHB NR5A2 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 CCNT1 KAT5 KANK1 MMP9 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 FOXA1 ALDH1A3 ZDHHC7 DHRS9 TLE3 ALDH1A2 TGFA PPID ALDH1A1 USF1 FOS CAV2 ALDH8A1 GREB1 FOXO3 ELK1 CHD1 PTK2 MMP7 EREG TFF3 UHMK1 TFF1 BTC ZDHHC21 EPGN CXXC5 AKT3 DLD USF2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors LTB4R2 OXER1 PTGER4 GPR17 PTGFR PTGER1 LTB4R TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR CYSLTR1 CYSLTR2 PTGIR C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RELA MAP3K7 UBA3 UBE2M PRKACG RAF1 PRKACA PRKACB CD209 CARD11 MALT1 ITPR1 RELB CLEC10A ITPR2 CLEC7A CLEC4A ITPR3 NFKBIA CARD9 CLEC4E MAP3K14 CLEC6A TAB1 PLCG2 PYCARD CLEC4C CLEC4D TRAF6 BTRC IL1B EP300 PAK3 HRAS PPP3CA PPP3CB PDPK1 CASP8 PPP3R1 UBE2N NFATC1 MUC13 NFKB1 NRAS CDC34 NFATC2 CHUK FCER1G IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 MUC12 PRKCD MUC15 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 MUCL1 PSMA1 MUC3A LYN MUC5AC PSMA2 MUC3B UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 NFKB2 PSMA7 MUC1 PSMB6 MUC2 PSMB7 PSMB4 MUC7 MUC4 PSMB5 MUC6 MUC16 IKBKG UBB MUC17 PSMB2 PSMB3 CREBBP MUC19 UBC PSMB1 MUC5B MUC20 MUC21 RPS27A ICAM2 ICAM3 FBXW11 UBE2V1 ADRM1 PSMC5 SYK PAK1 PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 PAK2 RPS6KA5 CUL1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A EIF4G1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IFNA2 OTUD5 IFNA8 ATG5 ATG12 RELA IFNA13 IFNA14 IFNA16 IFNA17 NFKB1 HSP90AB1 UBE2K ITCH IFNA10 PIN1 IFNA21 IFNB1 CHUK ISG15 PCBP2 IKBKB RIPK1 TBK1 IRF3 NFKBIA MAVS DHX58 RNF125 TKFC TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 TRIM25 IKBKE IRF7 SIKE1 TANK TRAF2 UBE2D1 HSP90AA1 TRAF3 TRAF6 UBA52 FADD CYLD NFKB2 IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG TOMM70 UBB CREBBP UBC RPS27A CASP10 NLRX1 EP300 NLRC5 UBA7 AGER RNF135 S100A12 MAP3K1 APP S100B SAA1 HMGB1 NFKBIB CASP8 UBE2L6 IFNA5 HERC5 IFNA4 IFNA7 IFNA6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR RUNX1 ELF1 CBFB IL3 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis PNMT DDC TH DBH DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts RXRA SLCO1A2 ABCB11 NCOA2 SLCO1B1 SLC27A5 FABP6 SLCO1B3 ABCC3 ALB SLC10A1 SLC10A2 STARD5 NR1H4 SLC51A NCOA1 SLC51B BAAT DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI2 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF18 TNFRSF1B TNFSF13 TNFRSF14 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells YAP1 ITGA5 GNAQ RELA NFKB1 ABL1 CHUK CAPNS1 CAPNS2 CAPN2 STAT1 PTPN1 IKBKG PPP2R1B ANXA2 PPP2R1A IKBKB PPP2CA PPP2R2A VCL PIEZO1 NFKBIA GNA11 IKBKE PTK2 ITGB3 ITGB1 ITGAV DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NFE2L2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR PSENEN NCSTN APH1B PSEN2 PSEN1 RELA NGFR NFKB1 ADAM17 TRAF6 APH1A SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 RELA PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 MAPK1 GNA13 GNGT2 F2RL2 GNA12 F2RL3 MAPK3 F2R GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 GNG10 F2 GNG12 GNG11 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling ERBIN STUB1 HBEGF HSP90AA1 ERBB2 EGF USP8 EGFR CDC37 UBA52 MATK PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 NRG1 AKT1 EREG NRG3 NRG4 NRG2 BTC AKT3 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases YAP1 ITCH PRDM1 ITPR1 ITPR2 ITPR3 NOS3 PRR5 CHD4 NTRK1 KIDINS220 CRK REST HGS VGF JUNB PRKCB RAC1 VAV3 CRKL VAV1 VAV2 MAPKAP1 TIAM1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ARHGEF7 MAPK7 APH1A PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 SOCS1 MDK WWOX ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 HIF1A FES POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K STAM POLR2L RALA WWP1 GTF2F1 GTF2F2 RAB4A PTPN18 PTPN12 PTPN2 AAMP MKNK1 SPRY2 ALK AHCYL1 PRKCE PGR MST1 MEF2A MST1R RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 USP8 STAM2 SPHK1 CDK5 ESR1 ADAM17 CYFIP2 PTPRU SH2B2 CMA1 FER TEC GRAP RAB4B KLB FLT3 IRS1 PPP2R1B PDE3B IRS2 PPP2R1A PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 NCK2 PTPRF FGF4 FGF6 NCK1 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 DIAPH1 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 ITGB1 TLR9 PIK3C3 TRIB3 ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 GFAP ATP6V1B1 ATP6V1A SHC1 PPP2R5D PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 SGK1 FGF20 THEM4 RHOA ATP6V1H PTPRJ MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 SRF ATP6V0A1 CDK5R1 MAPK3 PTPN1 INSR PTPN11 FGF16 CDC42 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FAM83B FGF10 HNRNPM HNRNPF SRC NRG1 DOCK3 GRIN2B HNRNPH1 DLG4 CALM1 DOCK1 FLT1 FLT4 KDR VEGFB VEGFC PTK2B VEGFD THBS1 PGF VEGFA ERBB2 ESRP1 MEMO1 CTNND1 CTNNA1 BAX CSK JAK2 SPRED2 RANBP9 SPRED1 CD274 IL2RG NELFB CHEK1 MMP9 BRAF MAP2K5 NCBP1 NRP2 NCBP2 CDH5 FRS3 TNS4 TNS3 LCK FYN HGF FGFRL1 FLRT2 FLRT1 CLTC CLTA AP2A1 NTRK3 AP2A2 NTF3 PDGFB AP2M1 RAP1B RAP1A PRKACG IGF2 PRKACA PRKACB IGF1 AP2S1 CXCL12 PTBP1 AP2B1 PLG STAT5A LAMA5 SH3KBP1 PXN LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 GRAP2 LAMC1 JAK3 HNRNPA1 PDGFRA KIT PTK6 HBEGF HDAC1 FLRT3 SIN3A NAB1 CTNNB1 COL6A2 NAB2 MET COL4A4 LYL1 F3 DNM2 COL6A1 ARC COL4A3 TRIB1 PTPRK TPH1 EPS15L1 ATF2 RRAD EPN1 ASCL1 SPRY1 PTPN3 EGR1 COL6A3 EGR2 EGR3 JUND COL4A5 EGR4 COL6A6 FOSL1 COL6A5 ID2 MLST8 ID1 MYCN MEF2C ID4 FOSB ID3 MYC CDK5R2 SPINT1 TGFBR3 HPN SPINT2 HGFAC MTOR YWHAB HSPB1 LRIG1 SOCS6 SH2B3 AKT1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 NCF2 NCF4 BRK1 MAPKAPK2 UBA52 MATK GIPC1 ANOS1 CYBB CYBA UBB RAPGEF1 UBC RPS27A RNF41 CUL5 MAPK14 MAPK11 PAK1 NCKAP1L WASF1 IRS4 PAK2 IGF1R CILP WASF2 CAV1 ERBIN BAIAP2 ABI2 FURIN PCSK6 ABI1 NGF PCSK5 SPP1 RICTOR ROCK1 ROCK2 ADAM12 STAT1 ELMO1 HSP90AA1 NEDD4 EGF CBL JUP EGFR CDC37 PLCG1 STMN1 RBFOX2 PDGFD SHB FGFBP3 FGFBP1 FGFBP2 ARF6 ALKAL2 ALKAL1 TIA1 TNK2 DOCK7 ADAP1 ESRP2 PTPRZ1 CSN2 TIAL1 SH2D2A PAG1 RANBP10 PTPRO PTN AXL PLAT FAM83D FAM83A MXD4 LTK EP300 THBS4 RASA1 THBS3 PRKCZ PAK3 BCAR1 NRP1 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 NRG2 ITGAV COL4A2 COL4A1 PTPRS SPARC STAT3 HDAC3 ITGA2 GABRG3 APOE GABRG2 COL9A1 GABRB3 COL9A3 GABRB2 COL9A2 GABRB1 NCOR1 GGA3 HDAC2 STUB1 STAT5B GABRQ GABRA1 GRB2 THBS2 ATF1 GALNT3 DNMT1 MAPKAPK3 MUC20 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 PTPN6 YES1 MEF2D STAT6 NTF4 PDGFRB S100B NTRK2 BDNF TGFA TAB2 FOS ELK1 PTK2 EREG BTC EPGN AKT3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HPGDS TBXAS1 PTGES PTGES2 PTGR2 CBR1 PTGIS PTGS2 PTGS1 CYP8B1 AKR1C3 PTGES3 PTGDS HPGD PRXL2B ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX BAX BID CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 CD22 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PTPN6 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME CYP2E1 UGT2B7 CYP2C9 UGT1A3 CYP2C8 ABCC2 CYP2C19 ACSM2B ABCC3 CYP2D6 SLC16A1 SLC22A7 UGT2B28 ALB CES2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 BCHE UGT3A1 UGT2A1 UGT1A8 GLYATL3 BSG UGT1A7 GLYATL2 UGT1A6 GLYATL1 ACSM2A CYP3A4 UGT2B10 ACSM5 UGT2B11 GLYAT UGT1A1 CES1 ACSM4 UGT2B15 UGT1A9 UGT2B17 UGT2B4 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer TP53 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection CLTC KPNA7 KPNA4 KPNA5 CLTA GBP1 KPNA3 CPSF4 TGFB1 EIF2AK2 ISG15 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 KPNA1 PABPN1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 NUP37 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 MLKL RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 CALR CANX RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 XPO1 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 HSPA1A KPNA2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNG13 CLTC CLTB WNT5B FZD7 WNT5A ROR1 GNB2 ROR2 CLTA GNB1 AP2A1 PRICKLE1 WNT1 FZD1 MAP3K7 GNB4 AP2A2 RYK FZD8 GNB3 GNB5 AP2M1 GNGT1 GNGT2 PRKG2 AP2S1 GNG3 SMURF2 ITPR1 ITPR2 GNG2 ITPR3 GNG5 AP2B1 GNG4 GNG7 GNG8 ARRB2 SCRIB VANGL2 DAAM1 PFN1 PARD6A PRKCB RAC1 DVL1 DVL2 DVL3 PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 RAC2 GNAO1 TCF7L2 TCF7L1 LEF1 TCF7 RHOA CTNNB1 TNRC6C MOV10 AGO3 AGO4 SMURF1 AGO1 AGO2 TNRC6A TNRC6B CAMK2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RAC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 WNT4 PSMC1 PSMC2 PRKCG GNG10 GNG12 GNG11 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 RB1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 SKP2 ANAPC15 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 FUCA1 MGAT3 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 B4GALT6 SEC22B B4GALT5 MAN2A2 LHB SERPINA1 SEC23A COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 MANEA TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B B4GALT2 TRAPPC3 B4GALT3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A B4GALT4 TRAPPC6B CGA SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 FUT8 NSF MAN2A1 CTSC MGAT5 CAPZA3 MGAT1 MGAT2 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A MGAT4C TMED2 MGAT4A SPTB DYNC1I1 MGAT4B B4GALT1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 ST6GAL1 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ST3GAL4 ANK1 AREG ST8SIA6 DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 ST8SIA2 TGFA ST8SIA3 YKT6 ARFGAP1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation MAPK1 RAPGEF1 RAP1A FRS2 NGF MAP2K1 MAP2K2 CRKL MAPK3 BRAF YWHAB RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MBD2 MAPK3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants UBC RPS27A FLT3LG CBL UBA52 FLT3 UBB MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN CSNK2A1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects APRT HPRT1 ADA TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs KIT HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 RNF8 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e DPM3 DPM1 DPM2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope DSG1 DSG3 FURIN PERP PCSK6 LCE6A IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KLK13 KLK14 LCE3E KLK12 LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A LCE1B KAZN LIPJ LIPN LIPM JUP PRSS8 PI3 LIPK PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 LCE1E LCE1F LCE1C CAPNS1 LCE1D LCE2B PKP4 LELP1 CAPN1 LCE2C LCE2A LORICRIN FLG SPRR2E SPRR2F DSG2 SPRR2G TCHH PKP1 KLK5 KLK8 PPL CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN SPRR1A SPRR1B DSG4 CASP14 LCE5A DSP PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds UGT2B7 GSTA3 GSTA1 COMT HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM MGST3 MGST1 MGST2 GSTP1 MTRR MAT1A NNMT CYP1A2 MAT2B AHCY SLC35D1 SLC35D2 SULT2A1 TPST2 TPST1 GSTM4 TPMT AS3MT AKR1A1 GSTT2 GSTT1 ESD GSTT2B UGT1A3 GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 MAT2A GSTA5 GSTA4 CHAC1 PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 ACSM1 BPNT2 ACSM2B BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 MTR HPGDS GSTZ1 GSTO1 NAT1 NAT2 GSTA2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 UGDH UGT2B4 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 MFAP5 BMP4 MFAP4 MFAP3 MFAP2 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 BMP10 LTBP4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP41 CEP43 DYNLL1 CKAP5 TUBA1A RPGRIP1L PRKACA MAPRE1 PAFAH1B1 DYNC1I2 MKS1 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 YWHAE CEP97 CC2D2A TUBB4B IQCB1 TUBB4A KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 YWHAG SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 RAB3IP CEP290 NINL RAB11A CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins ACOX1 HSD17B4 AGPS SCP2 ACAA1 PHYH TYSND1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria YWHAH YWHAZ SFN BCL2 AKT2 YWHAB PPP3CC BID YWHAE AKT1 PPP3R1 BAD YWHAQ YWHAG AKT3 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b MOGS STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B BCL2L1 CDKN1A GRB2 GAB2 FLT3 NOX4 PIM1 PTPN11 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP5B SYNJ1 INPP5A IMPA1 MTMR9 INPP4A IMPA2 MTMR7 INPP4B INPP5J MIOX ISYNA1 OCRL INPP1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 GLYAT VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance APOC4 LSR APOB VLDLR APOBR APOC1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism MRI1 ENOPH1 BHMT2 FMO1 BHMT ADI1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 MAT1A TST ETHE1 SLC25A10 CDO1 AHCY CBS MTAP CTH MTR GOT1 APIP MTRR TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 F9 PROC F10 PROS1 PROZ F2 BGLAP GAS6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System RELA ARPC1B ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 RAB9B IRAK1 NCKIPSD MGST1 C4A CAT RETN FUCA2 DNAJC3 RAC1 VAV3 CST3 PRKCQ UBE2N VAV1 VAV2 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 NFATC2 V1-11 CPB2 CFH V1-16 V1-13 MAPK8 C5AR2 CFI CDK13 CAPZA2 C5AR1 C4B_2 C2 ACTR10 C5 HSPA1B C6 SOCS1 C7 C9 CD19 IKBKB V2-8 V1-20 MYD88 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S UBE2D2 C1R UBE2D3 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 RAB3A POLR2E POLR2F POLR2H POLR2K DNAJC5 POLR2L KRT1 TOLLIP ACTB CSNK2B CNPY3 TLR8 CTSB TP53 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B NLRC4 RAB5C BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 ACTG1 FCAR ALAD FCGR3B PPP2R1B PGM2 PPP2R1A ACP3 SNAP29 PGM1 RNASET2 TNFRSF1B DYNC1LI1 PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 TXN DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PPP2R5D PRG3 DYNLL1 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 CHUK MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA DNASE1L1 PPP2CB CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CD93 CASP1 CD300A CASP2 IRAG2 ATAD3B OSCAR TYROBP DOK3 CRCP COPB1 ADGRG3 DPP7 MGAM POLR3GL HSPA6 GGH POLR3A POLR3B DNAJC13 ADA2 POLR3C IGF2R POLR3D POLR3E SELL TARM1 POLR3F POLR3G MAN2B1 MS4A3 POLR3H DDX3X TNFAIP6 POLR3K CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 NFKB2 ADGRE5 NAPRT ADGRE3 FGB HGSNAT DYNLT1 ATP6AP2 FGA PLAUR LRRFIP1 MMP8 MMP9 FGG CHI3L1 PDXK BIN2 FCN2 CLEC12A MVP FCN3 CAND1 CRP COLEC10 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN SKP1 PROS1 F2 CUL1 AP2A2 SLC15A4 RASGRP2 RASGRP1 RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB NPC2 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 LBP IGKV3-20 IGHV4-34 IGHV1-2 ITK IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 VTN IGLC2 BTRC IGKV3D-20 TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C AMPD3 IGKV5-2 APRT IGLC6 IGKV1-5 PNP IMPDH1 IMPDH2 LIMK1 PPP3CA EEF1A1 MYH9 PPP3CB UBE2L6 HERC5 PPP3R1 NFATC1 HLA-H HLA-B HLA-C HSP90AB1 IGHE HLA-E CDC34 DNM2 ATG7 CAB39 CTSS VAMP8 TLR6 HUWE1 IKBKE LAMTOR2 IRF7 LAMTOR1 TANK LAMTOR3 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 STBD1 CEP290 NFATC3 TUBB S100A1 CYBB CYBA RAB7A UBE2V1 UBA7 UBR4 PAK1 MEFV PSTPIP1 NCKAP1L SUGT1 WASF1 PAK2 WASF2 CALM3 CALM2 RASGRP4 BAIAP2 ATP8A1 ABI2 UBA3 ABI1 UBE2K ATP11B UBE2M ATP11A TIRAP CARD11 MALT1 ATP8B4 RELB CLEC10A CLEC7A CARD9 CLEC4A WIPF1 CLEC4E MAP3K14 WIPF2 CLEC6A DHX58 WIPF3 RNF125 TAX1BP1 RNF216 FCGR1A ARHGAP45 IQGAP1 ANO6 PLD1 IQGAP2 JUP ARHGAP9 WASL WAS STOM PAK3 MYO9B MAP2K1 COLEC11 HSP90B1 ITGAV FTH1 MASP1 FTL XRCC6 XRCC5 ITGAX DGAT1 FABP5 SIKE1 GPI CD36 HK3 KLRK1 PGAM1 KIR3DS1 DHX36 PRKDC FCER1A LAT2 NCR2 BCL10 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E NKIRAS2 LPO MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 TLR10 BCL2 TLR5 ALPK1 LRRC14 NLRX1 PELI3 BCL2L1 PELI2 PTPN6 NLRC5 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 STAT6 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB ELK1 POLR1C PTK2 POLR1D IFNA5 IFNA4 IFNA7 IFNA6 JUN IFNA2 IFNA8 AGPAT2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 CD209 GM2A NOS1 APEH ARSA FGR ASAH1 PECAM1 ITPR1 ITPR2 ITPR3 PSAP TKFC APOB MBL2 NOS2 NOS3 MME GLA P2RX7 CRK P2RX1 FADD IST1 CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 KPNB1 IL1B PELI1 TLR4 GSN TICAM2 TICAM1 PKP1 LY96 SDCBP HMGB1 CASP8 CASP5 CASP4 DSP DUSP4 DSG1 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 PRKCSH MAGT1 LTA4H NCSTN ADAM10 PSEN1 DNM1 GOLGA7 LGMN DDOST LPCAT1 ALOX5 DNM3 MAPK12 MAPK13 TRIM25 HPSE LYN BTK CYLD CNN2 CFL1 IFIH1 TRIM4 IKBKG ANXA2 TOMM70 RIPK2 MIF CAPZA1 AAMP PPIA RNF135 AHCYL1 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 NFKBIA MAVS CYFIP2 TAB1 RIGI TNFAIP3 HMOX2 SLC44A2 GLIPR1 TRAF2 TEC TRAF3 TRAF6 BIRC2 BIRC3 STK10 USP14 NOD1 NOD2 USP18 ORMDL3 PIK3CB TCIRG1 PTGES2 NCK1 TNIP2 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B CD180 ATP6V0E1 LY86 ATP6V1G2 EEA1 PDPK1 TASL RBSN IRF5 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 ATP6V0D1 FAF2 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS ATP6V0A2 PLD4 ATP6V1H MAPK1 PLD3 ATP6V0A4 PANX1 DHX9 ATP6V0E2 ATP6V1G3 ATP6V1D ALDH3B1 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PCBP2 PTPN11 PLD2 DEGS1 UNC93B1 TLR3 CKAP4 LRRC7 CALM1 DOCK2 DOCK1 MOSPD2 UBE2D1 MRE11 ARMC8 MYO5A FBXW11 OPTN RAB27A CEACAM1 SEM1 APP LAMP2 PPIE ARG1 SERPING1 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 SERPINA3 DEFB117 DEFB116 ORM1 FPR2 SLC11A1 SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 ORM2 DEFB110 TLR1 DEFB130A BPI QSOX1 PRTN3 DEFB130B S100A9 CAP1 DEFB4B S100A8 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PTAFR PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 ACLY ATG5 ATG12 SLC27A2 CTNNB1 ACAA1 ATF2 TREM2 SIGIRR IRAK3 MEF2C B4GALT1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 KCNAB2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 CASP10 ICAM3 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A CASP9 APAF1 CASP3 CFD C3 GZMM CFB VAPA CCT2 ROCK1 ZBP1 TREX1 DDX41 DTX4 TBK1 B2M IRF3 STING1 AP1M1 NLRP4 TRIM32 TRIM21 TRIM56 ELMO1 HEXB GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 FRK PLCG1 EP300 NDUFC2 NFKB1 PIN1 CHRNB4 ITGAL MUC12 MUC15 PTPN4 MUCL1 MUC3A MUC5AC MUC3B LGALS3 CFP MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 NEU1 MUC5B MUC20 MUC21 CTSA YES1 EEF2 MLEC CTSV CTSL CTSK MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 TYK2 JAK2 JAK1 IL6R MAP2K2 PTPN11 IL6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability HSP90AA1 JUP CTNND1 THEM4 CTNNA1 RICTOR CTNNB1 CDH5 MLST8 AKT2 PAK1 PAK3 MTOR RAC1 VAV3 NOS3 PRR5 PDPK1 PAK2 AKT1 VAV1 CALM1 CAV1 VAV2 MAPKAP1 AKT3 TRIB3 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB GLYCTK KHK ALDH1A1 TKFC REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC VCL PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis CDON ABL1 CTNNA1 CTNNB1 MAP2K6 CDC42 CDH2 NEO1 NTN3 CDH4 BNIP2 MEF2C CTNNA2 MYOG SPAG9 MEF2B MAPK14 MYOD1 MAPK11 MYF6 TCF4 MEF2D CDH15 MYF5 TCF3 TCF12 MAPK12 MEF2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SMARCB1 SMARCD1 SMARCD2 SMARCD3 PCGF5 HIPK2 SMARCC1 SMARCC2 RYBP ARID2 YAF2 SMARCE1 ACTL6A BMI1 CBX6 EP300 RING1 AUTS2 CSNK2A1 CSNK2A2 RNF2 SMARCA2 RUNX1 ACTL6B SMARCA4 CSNK2B CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 CBFB ARID1A ARID1B PBRM1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PLK1 PSMA6 PSMA3 PSMA4 HSP90AA1 PSMA1 CCNB1 PSMA2 CDKN1A UBA52 PSMD12 HSP90AB1 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 MAPRE1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A GTSE1 FKBPL ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 CCNB2 PSMD2 TP53 PSMD3 PSMD1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation GLI2 IHH HDAC4 CBFB BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion NEDD4L CHMP3 CHMP6 CHMP7 UBA52 UBB UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A PPIA VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 PDCD6IP MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MT-ND4L GFM2 MRRF MT-CYB MTRF1 MTRF1L MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 UBA52 IFNA10 IFNA21 IFNB1 EIF2AK2 IFIH1 JAK1 UBB CREBBP UBC TYK2 RPS27A STAT2 EP300 IRF3 CUL5 IFNAR1 MAVS RIGI ELOB ELOC RBX1 TRIM25 IFNA5 IFNA4 IFNA7 IFNA6 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNJ2 KCNJ4 KCNJ14 KCNK5 KCNK2 KCNK3 KCNK12 KCNK4 KCNK15 KCNK9 KCNJ12 KCNK6 KCNK7 KCNK1 KCNK10 KCNK13 KCNK16 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 PHOSPHO1 LPIN1 LPIN2 LPIN3 CHKB ETNPPL CEPT1 CHKA ETNK2 SELENOI PISD ETNK1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME SLCO1A2 SLC22A8 ABCG2 ALB SLC22A1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling NRG1 HBEGF PIK3R1 PIK3CA NRG3 EREG NRG4 BTC NRG2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling GNAS ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System PRL FGF10 TGFA AREG EGF MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 MAPK3 BRAF UBB GALNT3 PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 FRS3 RPS27A FGF4 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling SOS1 IL15RA STAT5A STAT5B IL15 SHC1 STAT3 IL2RB SOS2 GRB2 JAK3 JAK1 GAB2 IL2RG PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation CACNG4 FGF14 FGF13 FGF12 FGF11 SCN9A SCN11A CACNG6 CACNG7 SCN10A SCN8A CACNA1C RANGRF SCN5A CACNB1 SCN4A SCN4B SCN7A CAMK2B SCN1B SCN1A CAMK2D CAMK2A CACNA2D2 CACNB2 SCN3B SCN3A CACNG8 CALM1 CAMK2G SCN2A SCN2B SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog EVC2 IQCE EFCAB7 SEL1L EVC BOC GAS1 ADCY9 DRC4 CDON ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L CUL3 PRKACA KIF7 PRKACB WDR35 IHH IFT88 VCP SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 DERL2 ERLEC1 SMURF2 OS9 ADAM17 P4HB ARRB1 ARRB2 GNAS GLI1 SUFU BTRC NUMB PRKAR1B PRKAR2B PRKAR1A PRKAR2A NOTUM SPOP GLI3 GLI2 SMURF1 GPC5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 OFD1 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 DISP2 PSMC2 ULK3 SCUBE2 GRK2 SKP1 DZIP1 SPOPL SYVN1 CUL1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 TRIM24 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 ZMYM2 FGFR1OP2 GAB2 PIK3CA MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A AJUBA YWHAG PLK1 HSP90AA1 CCNB1 CEP57 CETN2 CEP164 UBA52 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 BTRC CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 PPP1CB HAUS5 CSNK1E UBB PPP2R1A TUBG1 HAUS2 HAUS1 CPAP UBC AKAP9 RPS27A BORA CEP63 SFI1 FBXW11 SDCCAG8 OPTN DCTN2 SSNA1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 SKP1 CCNB2 ODF2 CEP152 NEDD1 ALMS1 CUL1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes ZNF420 TNFRSF10C PRELID3A BNIP3L TNFRSF10B TNFRSF10A PERP PRELID1 TNFRSF10D TMEM219 NLRC4 BAX BID BIRC5 TP63 PPP1R13B FAS CREBBP CHM BBC3 RABGGTB RABGGTA NDRG1 BCL6 CASP10 PMAIP1 STEAP3 AIFM2 TP53AIP1 TP53INP1 CRADD TP53I3 IGFBP3 TP73 TP53 CASP6 ATM CASP1 TRIAP1 CASP2 PIDD1 TP53BP2 APAF1 BCL2L14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 IGLV2-11 IGLV1-40 HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LRP1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4C GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D PLA2G4E PLA2G4A PLA2G4B CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD MC2R POMC DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins GSN SPTAN1 DBNL PLEC CASP8 CASP6 ADD1 GAS2 CASP7 MAPT CASP3 VIM REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSF1 HSPA2 MAPK3 HSPA1B HSPH1 YWHAE NUP205 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA8 RPA1 RPA2 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation MIB2 ITCH UBE2L3 BTRC RNF111 UBE2V2 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF126 CDC34 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SOCS1 HACE1 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 LRRC41 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 KLHL5 PSMA5 RLIM PSMA6 TRIP12 PSMA3 KBTBD7 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 RNF19B UBE3A PSMD12 UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 NPEPPS PSMD13 RNF19A PSMA7 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 UBE2E3 TRIM4 PSMB4 FBXO17 PSMB5 FBXO15 UBE2E2 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 RNF14 KBTBD13 CUL3 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 RBBP6 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 SMURF2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 ASB2 ASB3 SKP2 ASB1 CDC20 SOCS3 SH3RF1 FBXO32 MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 FBXL21P SEM1 SKP1 CUL1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RRAS RAC1 PLXNB1 MET RND1 ARHGAP35 SEMA4D RHOA PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling XIAP RACK1 TRAF1 ULK1 MAP3K7 USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 RBCK1 NSMAF SMPD3 SMPD2 CHUK IKBKB RIPK1 SHARPIN TBK1 ADAM17 TAX1BP1 TAB1 UBE2D2 UBE2D3 TNFAIP3 RNF31 IKBKE SPATA2 TNFRSF1A OTUD1 STUB1 UBE2L3 TRAF2 BAG4 UBE2D1 MAPKAPK2 UBA52 BIRC2 FADD BIRC3 CYLD OTUD7B IKBKG UBB UBC RPS27A USP21 TNF OPTN OTULIN TRADD TAB3 TAB2 CASP8 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK6 KCNK7 KCNK1 KCNK2 KCNK3 KCNK10 KCNK4 KCNK9 KCNK13 KCNK16 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling RELA MAP3K7 PTPN22 CARD11 MALT1 NFKBIA PTEN PLCG2 VASP ITK TRAC CD3G CD3E TRAF6 PLCG1 CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 PTPRC ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 CD4 HLA-DRB1 PAG1 HLA-DQB2 LAT PIK3CB CD101 HLA-DQB1 NCK1 WAS PAK3 PDPK1 PRKCQ PIK3CA UBE2N PIK3R2 PIK3R1 NFKB1 CDC34 PTPRJ EVL CHUK IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 ZAP70 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 INPP5D PSMA2 TRAT1 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 CSK PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB RIPK2 PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TAB2 PAK2 CUL1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE MMAA PCCA MMUT PCCB AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production RACK1 NSMAF SMPD3 SMPD2 TNF TNFRSF1A DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade RAC2 LYN RHOG PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 RHOA RHOB GP6 FCER1G LCP2 PTPN11 PIK3CB CDC42 LAT PDPN MPIG6B CLEC1B PTPN6 PRKCZ SYK RAC1 LCK FYN VAV3 PDPK1 PLCG2 PIK3R3 PIK3CA VAV1 VAV2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template PCNA UBA52 NPLOC4 POLH USP10 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1 TGIF2 CCNK SERPINE1 FURIN CCNC HDAC1 CDKN2B UBA52 MAPK1 COL1A2 CCNT1 TFDP1 MAPK3 TFDP2 UBB UBC CDK8 SP1 SMAD2 RPS27A SMAD4 CDK9 YBX1 SMAD3 EP300 SMAD7 MYC JUNB RNF111 MEN1 WWTR1 E2F4 CCNT2 E2F5 RBL1 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD MAT1A MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation TYK2 JAK2 JAK1 MAP2K1 IL6R MAPK3 CDK1 PTPN11 IL6 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis NEU1 GLB1 CTSA FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation FGF18 FGF1 FGF9 FGF20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism RXRA OSBP NCOA2 AMACR SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 SLC51A NCOA1 SLC51B CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 SLCO1A2 OSBPL1A ABCB11 AKR1C1 FABP6 ABCC3 AKR1C2 ALB AKR1C4 SLC10A1 SLC10A2 CYP8B1 STARD5 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2E1 CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 PSIP1 HMGA1 OPSINS%REACTOME%R-HSA-419771.3 Opsins OPN1MW OPN1LW RHO OPN1SW OPN4 OPN3 RRH RGR OPN5 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type CSPG4 AGRN B4GALT7 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 PATL1 EDC3 EDC4 DCP1B XRN1 DCP2 DCP1A LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DDX6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells HNF1A MAFA RFX6 IAPP FOXA3 GCK FOXO1 PDX1 INS NKX6-1 AKT2 PAX6 SLC2A2 HNF4G AKT1 FOXA2 NEUROD1 NKX2-2 AKT3 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing SNRNP200 SNRPD2 SRSF6 SNRPD1 SRSF7 SNRPD3 SNRPB PRPF8 ZMAT5 RNPC3 ZRSR2 DDX42 YBX1 SRSF1 DDX23 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E POLR2F POLR2G POLR2H SF3B1 POLR2I POLR2J POLR2K POLR2L GTF2F1 SNRNP40 GTF2F2 PDCD7 SNRNP48 EFTUD2 NCBP1 NCBP2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRPG SRSF2 SNRPE SNRNP25 SNRPF CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN TNKS2 TNKS FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm SOX17 SMAD2 SMAD4 GSC SMAD3 MIXL1 TCF7L2 CDH1 GATA6 TBXT EOMES CXCR4 CTNNB1 GATA4 FOXA2 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway MAP3K7 TRAF6 BIRC2 BIRC3 CYLD ITCH CHUK NOD1 MAP2K6 NOD2 IKBKG RIPK2 IKBKB IRAK1 UBE2V1 CARD9 AAMP MAPK14 IRAK2 MAPK11 TAB1 TAB3 TNFAIP3 TAB2 MAPK12 CASP8 MAPK13 CASP1 CASP4 CASP2 CASP9 UBE2N GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 TAS2R16 FZD8 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 TAS2R46 RXFP4 MRGPRD FZD10 RXFP1 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R SSTR1 CGA SSTR2 WNT16 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 PTHLH CNR2 CNR1 TSHR ACKR1 C5AR2 C5AR1 C5 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 TSHB PF4 TAS1R2 TAS1R1 TAS1R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 LHB ADORA2B GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CRH WNT3 WNT8A WNT8B NPY CXCR1 CXCR2 OPRM1 OPRK1 POMC CXCL1 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CCR5 CXCR6 CCL7 CXCR4 CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 EDN1 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH CYSLTR2 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 HTR2B HTR2C ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 WNT3A WNT9A C3 SMO PTCH1 OPN1LW OXER1 OPN1MW RHO RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 SAA1 MC2R DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth COL4A2 CACNA1D NCAM1 COL4A1 SOS1 NRAS MAPK1 COL6A2 COL4A4 COL6A1 COL4A3 MAPK3 PTPRA CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 SPTB COL6A5 AGRN NCAN SPTBN4 SPTBN5 SPTBN2 PRNP ARTN GFRA1 GFRA2 GFRA4 NRTN CACNA1C SPTAN1 SPTA1 CACNA1S PSPN GDNF CNTN2 ST8SIA4 HRAS FYN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PTK2 SPTBN1 RPS6KA5 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses IFNA2 IFNA8 IFNA13 MAP3K7 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 STAT1 SAR1B NLRP3 SEC23A TBK1 B2M LARP1 IRAK1 IRF3 IFNAR1 STING1 MAVS HLA-A TLR1 TKFC G3BP1 TAB1 G3BP2 RIGI MBL2 CNBP TLR2 NUP205 POM121 NUP107 SFTPD NUP188 IL17RC IL17RA SEC24B AAAS NLRP12 NUP160 SEC24A IL17F POM121C IL17A NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 TRAF3 RANBP2 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C TLR7 NUP37 NOD1 NOD2 STAT2 UBE2N PIK3C3 MASP1 HLA-H PIK3R4 HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E CHUK PTPN11 IKBKB TRIM25 IKBKE IRF7 SIKE1 NUP214 IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 CREBBP TYK2 UBE2V1 PTPN6 IRAK2 RNF135 TAB3 TLR8 KPNA2 TAB2 IFNA5 IFNA4 IFNA7 IFNA6 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R2A BANF1 SIRT2 CCNB1 VRK1 CDK1 ANKLE2 LEMD2 EMD LBR LMNB1 CCNB2 KPNB1 LEMD3 PPP2R1A SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy TUFM UVRAG MAP1LC3B VPS41 VPS33B VPS39 VPS18 VPS45 VPS11 VPS16 VPS33A ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity RPS6KA1 HDAC1 LEF1 ZIC1 FOXD3 MAPK1 HINT1 TFE3 MITF TFEC ALX3 TBX3 CTNNB1 MAPK3 EDNRB EPRS1 ID1 CDH1 UBE2I SUMO1 PAX3 YWHAB YWHAE XPO1 SNAI2 GSK3B TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 YWHAZ POMC RARS1 WNT3A SOX10 LARS1 MARK3 AIMP1 AIMP2 QARS1 MARS1 MC1R MC4R DARS1 EEF1E1 MC3R CREBBP KARS1 POU3F2 IARS1 TFEB EP300 MC5R SOX2 SOX9 SIRT1 KIT AKT3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 DVL3 CCDC88C CXXC4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing OGG1 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli YAP1 COX5B COX5A RELA COX6C COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C IL6 YWHAE PRR5 EED CAT PDIA6 IGFBP7 SOD2 WFS1 CARM1 PRKCI DNAJC3 MED1 MAPKAP1 PRDX2 PRDX1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 DNAJA4 DNAJA2 CAPZA2 FKBP4 ACTR10 HSPA1B IKBKB SQSTM1 UBE2D2 UBE2D3 HIF3A LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP CDKN2B CSNK2A1 IGFBP1 CSNK2A2 CSNK2B TP53 GNG10 PGR GNG12 GNG11 GNG13 FKBP5 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 MAP2K6 PRDX6 MT2A MT1A MT1M MT1F MT1G MT1H MT1X MT4 MT1B MT3 MT1E GNG3 GNG2 GNG5 CLEC1B GNG4 GNG7 GNA11 GNG8 GSTP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 SMARCD3 NUP210 HMGA1 CACNG7 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 RBBP4 NUP37 RBBP7 TXNRD1 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 COX7A2L TXN RPS27 ITGB1 CITED2 VENTX PPP2R5B DYNLL1 DYNLL2 HBB NFYA NFYB NFYC CHUK DYNC1I2 BMAL1 PPP2CA COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 HM13 EIF2AK3 NOX4 FLT4 KDR HSPA6 HSPD1 VEGFA TLN1 VCL CDH5 PIEZO1 FYN SKP1 CCNA2 CCNA1 CUL1 CXCL8 MTF1 NUDT2 CREB3L3 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 CHD6 PRKACG GPX3 GPX6 PRKACA GPX5 PRKACB GPX8 GPX7 BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 TRPV4 BTRC RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A GCN1 RPS16 WDR59 RPS19 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT DEPDC5 RPS10 RPS13 KPTN WDR24 RPS12 SH3BP4 RPS9 RPS7 FNIP1 RPS8 FNIP2 PRKAR1B KICS2 RPS5 PRKAR2B CASTOR1 RPS6 PRKAR1A CASTOR2 RPSA PRKAR2A RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 CACNB2 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 HSP90AB1 PRKAA2 SEC31A RPTOR CALR MLST8 SLC38A9 ID1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD AKT1S1 IKBKE LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NCF1 NCF2 NCF4 BAG4 ACTR1A CYBB CYBA DCTN2 CUL7 DCTN3 PGRMC2 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A HSPH1 HYOU1 HBA2 RAMP2 CALCRL ADM ITGB3 HSP90B1 ITGAV ITGA5 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 BMI1 RPL22 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RNF2 RPL12 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 MAP2K3 MAP2K4 CREBBP MAPKAPK3 SP1 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 MAP2K7 MAPK10 FOS FOXO3 PTK2 AKT3 HIKESHI JUN CCAR2 DNAJC2 CXXC1 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 ADCY9 BAG5 DNAJB6 ADCY4 BAG2 ADCY3 BAG3 ADCY2 BAG1 ADCY1 HSPA4 ST13 ADCY8 ADCY7 HSPA7 HSPA12A ADCY6 HSPA12B ADCY5 IFNB1 CSRP1 SNCB PECAM1 GCLC GCLM APOB NOS3 GSK3A P2RX7 GNAS CDKN2D CDKN2C DNAJB11 IL1A FBXL17 BACH1 TLR4 SLC7A11 LY96 OMA1 MAPK7 ADD1 ATF6 CRYAB MAP3K5 DELE1 HERPUD1 MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 KEAP1 AR NRF1 NPLOC4 RPLP0 UBXN7 DPP3 HSPA9 UFD1 IKBKG ANXA2 TALDO1 SOD1 PIK3CD CAPZA1 FKBP14 GOSR2 GPX1 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 KLHDC3 DDX11 WIPI1 YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP NLRP3 ESR1 NFKBIA MDM2 MDM4 GJA1 HMOX2 PKN2 STIP1 PIK3CB TCIRG1 CAPZB AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 PDPK1 PIK3CA ATP6V1B2 EPO TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 CACNA2D1 PIK3R2 ABCG2 ATP6V1H MAPK1 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MAPK3 PTPN1 CACNB1 CACNB3 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 HSPE1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN PPP2R2A RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 ATM ATR HSPA5 HSBP1 HSF1 ATP7A DEFA5 CAPNS1 CAPNS2 CAPN2 ATOX1 STOML2 PHB2 YME1L1 P2RY2 CDKN1A CDKN2A SIN3A CDK2 CTNNB1 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 ATF3 ATF4 TNRC6C MOV10 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B PSMD8 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 NUP214 DIS3 IDH1 PRKCD PSMA5 PPARGC1A PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 DCP2 PSMD12 SERP1 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 SIRT1 HSPA1A SIRT3 MMP14 PPARA CYCS SPP1 RICTOR CUL3 STAT1 TRIM21 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 HIGD1A H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KDM6B H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 NFKB1 H2AC20 HDAC3 NRIP1 COX4I1 COX4I2 TBL1X NCOA1 ARNT NCOR2 NCOR1 TBL1XR1 CRTC2 CRTC3 CRTC1 CLOCK NPAS2 HELZ2 RAI1 CHD9 TGS1 MEF2D COX7B GFPT1 COX7C EDEM1 COX8A SYVN1 COX8C INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling SOS1 SHC1 IL5 IL3RA PIK3R2 INPP5D IL2RB PIK3R1 JAK3 JAK2 JAK1 IL2RG CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 INPPL1 GAB2 PIK3R3 PIK3CA IL2RA IL5RA CSF2RB CSF2RA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex UBC TAB3 RPS27A TAB2 MAP3K7 TRAF6 UBA52 IRAK2 UBB TAB1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors HCAR3 HCAR1 HCAR2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants ERBIN HSP90AA1 ERBB2 CDC37 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor GNG13 GNB2 GNB1 GNAS GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNG10 PTGIR GNG12 GNG11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD MMACHC MMADHC DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis RIPK1 RPTOR MLST8 PIK3R4 NFKBIA ATG14 RETREG1 MTOR RICTOR BECN1 TAOK1 PRR5 DAXX NFKBIB PIK3C3 MAPKAP1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK H2AC20 ERCC6 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MYBBP1A ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs BRCC3 UBA52 H2AC20 STAM H2AC1 PSMD14 H2AC25 H2AC21 STAMBP ABRAXAS1 BRCA1 BABAM1 BABAM2 ABRAXAS2 UIMC1 UBB NLRP3 BARD1 UBC H2AC19 H2AC14 RPS27A KAT2B EP300 H2AC8 H2AC6 H2AC7 STAMBPL1 H2AC17 H2AC12 MYSM1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells KLF4 NR5A1 DPPA4 SMAD2 FGF2 SMAD4 STAT3 SALL4 POU5F1 SOX2 NANOG PRDM14 FOXD3 CRIPTO PBX1 LIN28A ZIC3 HIF3A ZSCAN10 EPHA1 EPAS1 SALL1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM KCTD6 RUNX1 ESR1 CBFB AXIN1 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors FSHR CGA GPHA2 LHB TSHB GPHB5 LHCGR TSHR GNRH2 GNRHR2 GNRH1 FSHB GNRHR DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands DLL1 SIN3A BDNF CRH HDAC1 SST SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 NTRK1 STAT3 NGF NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 PDYN POMC GNGT2 GNG10 OPRM1 GNG12 GNG11 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 CD9 ZP3 ZP2 ZP4 HVCN1 SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors LPAR4 GPR17 P2RY12 P2RY6 P2RY13 P2RY10 P2RY2 P2RY11 P2RY14 P2RY1 P2RY4 LPAR6 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 FGF9 NRAS FGF20 HRAS FGF23 FRS2 PTPN11 FGF16 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB PDPK1 AKT2 THEM4 TRIB3 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMA5 LAMA2 DRP2 DMD LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 UTRN SNTG2 DAG1 SGCE SGCD AGRN SGCA SGCB SGCG SNTA1 SGCZ DTNA DTNB SSPN SNTB1 SNTB2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBC GBP1 RPS27A UPK1A EPCAM UBA52 HBB GBP2 GBP6 UBE2D2 GBP4 HBA2 CASP4 CALM3 CALM2 CALM1 UBB TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TRAF2 LTA TRAF3 TNFRSF12A TNFSF12 MAP3K14 BIRC2 TNFRSF13C TNFRSF11A BIRC3 CD40LG LTBR LTB TNFSF13B TNFSF11 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression RXRA NCOA2 SERPINE1 NCOA6 SMARCD3 TBL1X CARM1 BMAL1 NCOA1 CLOCK NPAS2 HELZ2 CREBBP BHLHE40 CHD9 BHLHE41 NAMPT KLF15 TBL1XR1 AVP NOCT MED1 TGS1 F7 BMAL2 PPARA REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors SFN YWHAZ FOXO6 FOXO3 FOXO1 AKT1 AKT2 FOXO4 YWHAQ YWHAG YWHAB AKT3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation MET HGF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency ACAT1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis CHST2 B4GALT4 CHST3 B3GNT3 ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 PRELP CHST6 OMD KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis PPIA BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol DDX21 NOP56 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 PELP1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 DDX49 RPS28 DDX47 RPS29 WDR3 FCF1 RPS20 FAU RPS21 PWP2 RPS24 RPS27 RPS23 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 RPP30 UTP25 HEATR1 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 RPP38 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 RPP21 UTP4 RPP25 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 RPP40 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPP14 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L DIS3 RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EBNA1BP2 EXOSC7 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E NOB1 EXOSC4 RIOK2 RIOK1 TEX10 SENP3 EXOSC9 MTREX GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 NCL PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines DHFR SLC46A1 SHMT1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 MTHFD1L MTHFD2 SHMT2 MTHFD2L SLC25A32 FOLR2 SLC19A1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins APBB1IP SOS1 TLN1 FN1 SRC RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate TBX6 POU3F1 WNT3A ZEB2 SOX2 FGF8 ZNF521 SOX1 GBX2 OTX2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD PRELP OMD KERA ACAN OGN ST3GAL3 LUM GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XRCC1 POLE4 CUL4A RPA3 PPIE POLE2 POLE3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex H2BC9 H2AZ2 H4C9 H2BC8 BCL9L H2BC5 RUVBL1 H2BC3 H3-4 PYGO1 TCF7L2 H2BC1 BCL9 PYGO2 TCF7L1 HDAC1 H2AC20 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 ASH2L MYC TRRAP DPY30 WDR5 CDC73 AXIN2 LEO1 RBBP5 KAT5 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 TERT EP300 H3-3B MEN1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 SMARCA4 RUNX3 H2BC13 H2BC14 TLE3 H2AJ H2BC15 H2BC11 H3C15 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF NTRK3 LRRC4B IL1RAPL2 PPFIBP1 PPFIBP2 PPFIA1 PPFIA4 SLITRK3 PPFIA3 PPFIA2 SLITRK5 SLITRK2 SLITRK1 IL1RAPL1 SLITRK4 SLITRK6 PTPRD DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA ABAT ALDH5A1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 MAPK14 GNG7 GNA11 GNGT1 GNG8 GNGT2 GNG10 P2RY1 PLA2G4A GNG12 GNG11 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones DUOX1 TPO TPH2 IYD ASMT DUOXA1 CGA AANAT DUOXA2 DUOX2 TSHB PNMT DDC TH DBH DIO1 TPH1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy ACY1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) GUSB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) GRM8 TAS2R4 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GABBR2 TAS2R50 GABBR1 TAS2R19 TAS2R42 TAS2R45 TAS2R40 TAS2R60 TAS2R41 TAS2R43 CASR TAS2R46 TAS1R2 TAS1R1 TAS1R3 TAS2R30 TAS2R7 TAS2R31 GRM1 GRM5 TAS2R38 TAS2R8 TAS2R39 TAS2R20 GPRC6A TAS2R9 GRM3 GRM2 GRM4 GRM7 TAS2R1 GRM6 TAS2R3 TAS2R5 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER ACTR5 RAD23A YY1 ACTR8 RUVBL1 RAD23B PARP1 CETN2 UBA52 INO80 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ACTB UBB TFPT ACTL6A UBC RPS27A DDB2 PARP2 DDB1 COPS7B XPC COPS7A CUL4A COPS3 RBX1 COPS6 COPS5 MCRS1 NFRKB COPS8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations DAG1 POMT2 POMT1 POMGNT1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling ERBIN HSP90AA1 ERBB2 CDC37 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling YWHAZ SOS1 CRK STAT5A STAT5B SHC1 IL5 LYN IL3RA PIK3R2 CBL INPP5D IL2RB PIK3R1 TEC BLNK JAK3 JAK2 PRKACA JAK1 IL2RG PTPN11 CSF2 PIK3CB RAPGEF1 PIK3CD PTPN6 IL2 YES1 HCK IL3 SYK FYN INPPL1 GAB2 PIK3R3 CRKL PIK3CA IL2RA IL5RA VAV1 CSF2RB CSF2RA EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation EEF1B2 EEF1A2 RPL4 RPL5 RPL30 RPL3 EEF1G RPL32 RPL31 RPLP1 EEF1D RPL34 RPL10L EEF1A1P5 RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DBT DLD REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL CRIPTO ACVR1B LEFTY2 ACVR2B LEFTY1 ACVR2A CRIPTO3 ACVR1C DAND5 CFC1 CER1 NODAL SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR EIF2AK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages PRL FGF10 LAMA5 FGF2 LAMA2 LAMB3 AREG LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN TGFA REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 EHMT1 SETD9 UBC RPS27A PRMT5 EP300 UBA52 MDM2 MDM4 CHEK2 TTC5 JMY SMYD2 TP53 ATM KMT5A UBB EHMT2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FZR1 BTRC PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPOP PSMD12 PSMD11 PSMD14 PSMD13 CCND1 CUL3 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 CSNK2B PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 YWHAG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 RIPK3 CASP8 MLKL WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 DVL2 CSNK2B DVL3 CSNK2A1 CSNK1E PIP5K1B CSNK2A2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling WWP1 UBC RPS27A NEDD4 UBA52 SRC UBB ITCH SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R4 GNG13 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism GYG1 GBE1 UBA52 PYGM GYS1 GYS2 PHKG1 PHKG2 GYG2 EPM2A AKR1E2 PHKA1 PHKB PHKA2 PPP1R3C NHLRC1 GAA UBB PYGB PYGL UBC PGM1 RPS27A UGP2 AGL CALM1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling GNG13 GNB2 HBEGF GNB1 GNB4 PIK3R2 GNB3 PIK3R1 PRMT1 GNB5 NRAS GNGT1 MAPK1 GNGT2 GNAT3 CCND1 SPHK1 SRF MAPK3 GNG3 ESR1 GNG2 GNG5 GNG4 GNG7 ESR2 SRC GNG8 GNAI3 NOS3 XPO1 GNAI1 GNAI2 AKT1 CALM1 HSP90AA1 EGF EGFR CDKN1B S1PR3 MMP9 STRN MMP2 BCL2 AREG AKT2 PRKCZ HRAS MMP3 ZDHHC7 PDPK1 TGFA FOS CAV2 FOXO3 ELK1 IGF1R GNG10 MMP7 PTK2 EREG PIK3CA PIK3R3 UHMK1 BTC ZDHHC21 CAV1 GNG12 EPGN AKT3 GNG11 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling PITPNA TRPC7 TRPC5 DCC TRPC6 NTN1 TRPC3 TRPC4 TRPC1 PLCG1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction NEB DMD MYH3 MYH8 MYH6 TNNI1 TNNI2 TNNI3 TMOD3 TPM4 TPM3 DES VIM ACTN3 ACTN2 MYL4 MYL1 MYL2 MYL3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TPM2 TMOD4 TTN TPM1 TMOD2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA YY1 TFAP2A VEGFA ERBB2 TFAP2B ESR1 EGFR TFAP2C CGB8 TGFA KIT ATAD2 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RBM8A PRKACG PRKACA CXCR4 PRKACB ETF1 GSPT2 GSPT1 CXCL12 UPF3A CAP1 UPF2 LDB1 VASP CAP2 ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RAC1 RPSA PRKAR2A RPS3A RPS26 RPS25 PPP3CB RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 SOS2 HOXA2 FLRT3 ZSWIM8 MSI1 LHX3 LHX2 LHX4 LHX9 COL4A5 NELL2 GPC1 PSMD8 PSMD6 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 CUL2 PSMD1 PRKCA ROBO2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ARHGAP39 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SLIT1 UBC PSMB1 SLIT3 RPS27A ADRM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABL2 EIF4G1 PAK2 PAK4 ABL1 ISL1 DCC NTN1 USP33 SRGAP3 SRGAP1 NCK2 NCK1 PFN1 PFN2 PAK6 PAK3 PAK5 MYO9B SRGAP2 NRP1 EIF4A3 RPS27 SOS1 MAGOH RPL4 RHOA RPL5 RPL30 RPL3 RPL32 RPL31 EVL RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 CDC42 RPL38 RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 CLASP1 RPL22 CLASP2 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 SRC RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 AKAP5 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 CASC3 NCBP1 NCBP2 SEM1 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g ALG12 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 PSMD1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions KDELR1 YBX1 LYN NCL FURIN CLINT1 TSG101 GBF1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L CCNT2 TAF4B ELOB ELOC CCNH POLR2A CDC73 TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 TAF15 GTF2H2 LEO1 TAF12 GTF2H3 TAF13 SUPT5H PAF1 GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 TAF10 SUPT6H IWS1 EAF1 EAF2 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair LIG1 FEN1 PARP1 PARP2 POLB PARG APEX1 ADPRS FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion GNA14 GNAQ CD36 GNA15 PLCB3 PLCB1 FFAR1 PLCB2 ACSL4 ACSL3 GNA11 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification RCC1L RPUSD4 NGRN RPUSD3 TRMT61B TRUB2 MTERF3 SLIRP MTPAP FASTKD2 LRPPRC INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 CDC42 RAC1 SRGAP2 SRGAP3 ARHGAP39 SRGAP1 SLIT2 ROBO1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 NPLOC4 POLH RPA3 VCP SPRTN UFD1 UBB DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT GALT SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis TBX6 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 LEF1 PSMD11 PSMD14 PSMD13 PSMA7 CTNNB1 PSMB6 PSMB7 PSMB4 PSMB5 MESP2 DLL3 PSMB2 HES7 PSMB3 MSGN1 RBPJ RIPPLY2 PSMB1 LFNG ADRM1 EPHA4 PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 NOTCH1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F PIK3R1 POLR2G POLR2H NRAS PLCG1 POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 PIK3CA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription CREBBP FLT4 RBPJ MAML2 MAML1 SMAD3 KAT2B HEY1 KAT2A ACTA2 HES1 SNW1 EP300 HEY2 HES5 MAMLD1 MAML3 NOTCH2 NOTCH1 NOTCH4 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RELA MAP3K7 PIK3R2 PIK3R1 NFKB1 CDC34 CHUK IKBKB CARD11 MALT1 NFKBIA UBE2D2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 TRAC PSMA2 INPP5D CD3G TRAT1 CD3E TRAF6 CD3D UBA52 TRBV12-3 PSMD12 TRAV29DV5 PSMD11 TRBV7-9 BCL10 TRBC1 PSMD14 BTRC HLA-DQA2 PSMD13 HLA-DQA1 HLA-DPA1 PSMA7 HLA-DRB5 TRAV19 PSMB6 HLA-DRB4 PSMB7 HLA-DPB1 PSMB4 TRAV8-4 HLA-DRA PSMB5 IKBKG CD4 HLA-DRB3 UBB HLA-DRB1 RIPK2 HLA-DQB2 PSMB2 PIK3CB PSMB3 HLA-DQB1 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 LCK SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 PDPK1 TAB2 PRKCQ PIK3CA UBE2N CUL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription JUN HDAC1 HDAC3 KDM1A MAPK1 MBD3 MAPK3 ATF2 EGR1 GATAD2B GATAD2A RPTOR MLST8 CHD3 SLC38A9 BMI1 CBX6 RING1 HDAC2 MTOR RNF2 RRAGA RRAGC SUZ12 CBX8 PHC2 RHEB RRAGB PHC1 NR2E1 RRAGD CBX4 CHD4 LAMTOR2 CBX2 LAMTOR1 PHC3 SNAI2 LAMTOR4 LAMTOR3 LAMTOR5 MECOM RCOR1 ATN1 EED SALL4 MAF1 HDAC5 MTA2 HDAC7 RBBP4 EZH2 MTA1 REST MTA3 RBBP7 SNAI1 TP53 PPARG CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 RXRA CYCS PTK6 COX5B COX5A STAT3 COX6C HBB HDAC3 SIN3A COX4I1 COX4I2 BLVRB TBL1X COX6A1 BLVRA NCOA1 COX6A2 FABP1 MT-CO1 NLRP3 COX6B2 COX6B1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 HIGD1C ABCC1 ALB HBA2 TXNIP HMOX1 MT-CO2 MT-CO3 HM13 HMOX2 NCOA2 NCOA6 SMARCD3 CARM1 BACH1 HELZ2 CREBBP CHD9 MAFK NFE2L2 MED1 TGS1 STAP2 COX7A2L COX7B COX7C COX8A COX8C PPARA PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNG CHRNE CHRNA6 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions ITGA3 ITGA6 ATP1B3 PPIL2 ATP1B2 ATP1B1 SLC16A8 MMP1 SPN SLC16A3 SLC3A2 SLC7A11 SLC7A10 SLC16A1 MAG PPIA BSG SLC7A5 SLC7A6 ITGB1 SLC7A7 CAV1 L1CAM SLC7A8 SLC7A9 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling TYK2 IL23R STAT4 JAK2 IL12B STAT3 IL23A IL12RB1 P4HB DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage APRT DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PFKFB2 PRKACG PFKFB1 PFKFB4 PRKACA PFKFB3 PPP2R5D PRKACB PPP2R1B PPP2R1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RHOC H2AC20 RHOA RHOB KDM1A PPP1R12B PPP1R14A KLK3 KLK2 KDM4C YWHAB YWHAE MYL9 YWHAQ YWHAG AR YWHAH PKN3 YWHAZ SFN NCOA2 CDC25C PKN2 PKN1 PPP1CB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 PPP1R12A H2AC6 H2AC7 PAK1 RAC1 H2BC17 MYL12B H2BC12 MYL6 H2BC13 MYH9 H2BC14 MYH14 H2AJ MYH11 PDPK1 H2BC15 MYH10 H2BC11 H3C15 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis UBC PGM1 GYG1 RPS27A GBE1 UBA52 GYS1 GYS2 UGP2 GYG2 EPM2A PPP1R3C NHLRC1 UBB APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC16 ANAPC7 UBE2C UBC UBE2E1 UBE2D1 RPS27A ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC20 UBB ANAPC15 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions CACNA1D NCAM1 COL4A2 GFRA1 COL4A1 GFRA2 GFRA4 NRTN CACNA1C CACNA1S PSPN COL6A2 COL4A4 COL6A1 GDNF COL4A3 CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 CNTN2 COL6A6 COL9A2 ST8SIA4 COL6A5 AGRN NCAN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PRNP ARTN GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP5 YWHAZ GP9 RAF1 PIK3R1 VWF FLNA GP1BA GP1BB SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol RXRA ACOX2 ABCB11 NCOA2 AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 ACOT8 BAAT HSD3B7 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall IGHV3-23 IGLV IGLV2-8 SELP IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 SLC16A8 IGKV1D-39 PECAM1 SLC16A3 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SLC16A1 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 APOB IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 IGLC1 PPIL2 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MMP1 IGKV1-33 SLC3A2 IGLC7 SLC7A11 IGHV3-53 SLC7A10 EPCAM IGKV5-2 IGLC6 IGKV1-5 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 SDC1 LYN INPP5D DOK2 GP6 PF4 MIF PPIA CAV1 ITGA3 JAM2 ITGA6 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 OLR1 SPN VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 PSG9 FCAMR PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD ANGPT4 ANGPT2 MERTK CD2 CD244 PLCG1 ITGAM ITGB2 PIK3CB F11R HRAS SIRPG GRB7 PIK3CA ITGB3 ITGB1 L1CAM ITGAV ITGA5 SOS1 TNFRSF10B SHC1 TNFRSF10A PIK3R2 PIK3R1 TNFRSF10D NRAS ITGAX FCER1G ITGAL CEACAM3 CEACAM6 PTPN11 CEACAM8 CD47 TSPAN7 CD44 ITGA4 CD58 PICK1 SIRPA SELL TREM1 PTPN6 CEACAM1 YES1 LCK FYN PROC BSG PROS1 F2 IGHA1 GAS6 IGHA2 JCHAIN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 SOS1 NCK2 SOS2 NCK1 SLIT2 ROBO1 PAK6 PAK1 PAK3 RAC1 PAK5 PAK2 PAK4 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling ACVR2A INHBA INHA TGFBR3 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling PTPN7 PTPN5 IL18R1 PTPN2 PTPN4 SIGIRR SMAD3 STAT3 TBK1 PTPN6 PTPN13 PTPN20 PTPN23 IL18BP CASP1 PTPN18 IL37 PTPN12 PTPN11 PTPN14 PTPN9 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle ERBIN MPP7 VANGL1 ARHGAP32 RHOG ARHGEF5 PIK3R1 ESYT1 ARHGEF26 KALRN ELMO2 MCF2 CDC42 DOCK5 DOCK4 ARHGDIG ANKLE2 DOCK3 ARHGDIA SHMT2 LAMTOR1 NDUFS3 CYFIP1 DOCK2 DOCK1 TFRC PLD1 IQGAP2 STX5 ARHGAP1 HSPE1 ARHGAP39 LETM1 ARHGAP5 ARHGAP35 OPHN1 STBD1 ARHGDIB MAP3K11 EMD LBR TMPO PLEKHG3 VRK2 LEMD3 DEPDC1B ARFGAP3 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO ITSN1 ARHGAP21 PREX1 LMAN1 MCF2L PGRMC2 NDUFA5 VAV3 VAPB KTN1 PAK2 YKT6 ARHGEF16 PAK4 DIAPH3 ITGB1 VAV1 VAV2 CAV1 MCAM REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 SIN3A RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RELA DDX5 NPM1 ITCH VCP NLRP3 ACE2 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 MAVS TKFC RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI PARP10 PARP6 SFTPD GSK3A PARP4 PARP16 YWHAQ PARP9 PYCARD PARP14 YWHAG PARP8 YWHAH UVRAG MAP1LC3B PPIB TRAF3 TRAF6 RB1 BECN1 TLR7 RIPK3 TMPRSS2 RPS4Y2 KPNB1 RPS27L GALNT1 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C HNRNPA1 RPS10 CHMP4B EP300 RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RUNX1 CHMP2B RPS3A RPS26 CHMP2A EEF1A1 RPS25 RPS28 RPS29 PDPK1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PIK3C3 CHMP3 CHMP6 CHMP7 PIK3R4 NFKB1 BST2 PRKCSH GANAB MGAT1 MOGS PCBP2 CANX UBE2I SUMO1 YWHAB FKBP1A ST6GALNAC2 TRIM25 CASP1 IKBKE SIKE1 VHL GSK3B ST6GAL1 SFN YWHAZ UBA52 ST6GALNAC3 ST6GALNAC4 IFIH1 UBB TOMM70 UBC SP1 ST3GAL4 RPS27A BCL2L1 ZCRB1 ST3GAL1 ST3GAL2 ST3GAL3 PPIA IRAK2 PSMC6 KPNA2 CTSL PPIH PPIG CAV1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals DCC UNC5A NTN1 UNC5B SRC UNC5C PTPN11 UNC5D REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBC RPS27A TICAM1 TLR3 TBK1 TRAF3 IKBKE OPTN UBA52 TANK UBB PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy MAP1LC3A VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN TOMM40 UBE2D2 UBE2D3 MTERF3 PINK1 UBE2N VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism FASN PDZD11 SLC5A6 PANK4 VNN1 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP1 ENPP2 ENPP3 SLC25A42 AASDHPPT RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking RAB14 RAB27B TRAPPC4 RAB9A RAB6B RAB9B RAB39A YWHAE MAP1LC3B RAB33B RAB31 RAB5B RAB5C RAB3IP RAB11A RAB6A ARF6 RAB1A TRAPPC1 RAB1B RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 SYTL1 GAPVD1 RIC1 RAB32 RAB35 TBC1D24 RGP1 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB3GAP2 TRAPPC2L DENND6A RAB10 RIN1 TBC1D20 RIN2 RAB3GAP1 GABARAP TBC1D13 RAB18 TBC1D14 TBC1D17 TRAPPC2 TBC1D15 TBC1D16 TRAPPC3 ANKRD27 TBC1D10C DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B TRAPPC8 MON1A MON1B TRAPPC6A DENND1C TRAPPC6B DENND1B GDI1 ULK1 DENND1A RAB8B DENND2D TRAPPC10 DENND2C DENND2B DENND2A RAB3IL1 RAB33A TBC1D2 GDI2 RABEP1 TBC1D3 TBC1D7 RAB7B RABGAP1 DENND3 RAB21 ALS2CL CHML RAB11B RAB12 RAB13 CHM GGA2 GGA1 GGA3 TSC2 TSC1 AKT1 ALS2 RAB3A RAB4A RAB7A OPTN RAB27A RAB8A AKT3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation EOMES FGFR1 SNAI1 TBXT SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2BC9 H2AZ2 H4C9 H2BC8 TBP TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 RRP8 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 H2BC11 H3C15 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters POLRMT TFAM MTERF1 TFB2M G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC RBBP4 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism ENO1 PGK1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal MGMT ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 FBXO5 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis FAR2 AWAT1 AWAT2 FAR1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases YY1 RUVBL1 H2AC20 TGFB1 H2AC1 TGFBR1 TGFBR2 KDM1B INO80C INO80B INO80E INO80D SMAD7 OGT PSMD8 PSMD6 H2AC17 H2AC12 PSMD7 PSMD2 PSMD3 NFRKB SENP8 PSMD1 HCFC1 ACTR5 PSMA5 PSMA6 PSMA3 ACTR8 PSMA4 PSMA1 PSMA2 UBA52 INO80 PSMD12 PSMD11 PSMD14 H2AC25 H2AC21 USP15 PSMD13 BAP1 PSMA7 PSMB6 FOXK2 PSMB7 UCHL1 FOXK1 PSMB4 PSMB5 ACTB UBB TFPT PSMB2 ACTL6A PSMB3 BARD1 UCHL3 UBC H2AC19 PSMB1 UCHL5 H2AC14 RPS27A ASXL1 NEDD8 ADRM1 H2AC8 ASXL2 H2AC6 PSMC5 H2AC7 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MBD5 PSMC2 MBD6 MCRS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling JUN IGF2BP1 MAPK6 MAPK4 KALRN DNAJB1 PRKACG PRKACA PRKACB CDC42 TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B HSPB1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 NCOA3 PSMA2 CDC14A UBA52 PSMD12 PSMD11 CDK1 CCND3 PSMD14 PSMD13 MAPKAPK5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDC42EP5 RPS27A CDC42EP3 CDC42EP2 FOXO1 ADRM1 PSMC5 PAK1 PAK3 PSMC6 RAC1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SEPTIN7 CDC14B FOXO3 PAK2 RAG2 RAG1 ETV4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFB105B DEFA1B DEFB1 DEFB104B DEFA6 DEFB109B DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 CCR6 DEFB133 DEFB132 PRSS3 DEFB108B DEFB108C PRSS2 CCR2 CD4 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC TP53 ARG2 SLC25A2 SIRT5 SLC25A15 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling TAS2R10 TAS2R13 TAS2R14 ADCY9 TAS2R16 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A ITPR1 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP TAS2R38 PDE11A PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 GPR183 PNOC GPR18 SSTR3 PTH1R GPR37 PDE10A GPR31 PTH2R GPHA2 GNAS GPR55 GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 TAS2R42 TAS2R45 CRHR1 PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW TRIO RASGRF2 ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 VAV3 HCAR1 ARHGEF11 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ ARHGEF15 PLEKHG5 HEBP1 ARHGEF17 GRM3 ARHGEF16 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A AGT GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP APP F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 RGSL1 GRPR CYSLTR1 CCL1 EDNRA CCL19 EDNRB PROK2 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 GPR17 ACKR3 NMB CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK ADORA1 HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HBEGF HRH2 HRH4 DRD1 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA PAK1 C3 ROCK1 ROCK2 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology NR5A1 CLTB YAP1 RELA WNT1 PERP ARPC1B ARPC1A ARPC4 ARPC5 MAMLD1 SLC2A2 ARPC2 ARPC3 IHH ACTR3 ACTR2 CNOT10 CNOT11 TCF3 YWHAE LDB1 LEP DPY30 CHD4 YWHAG CSF1 YWHAH EED MTA2 CARM1 DAG1 MMP2 MAML2 MAML1 TRIO ITSN1 MED1 RAC1 MED8 VAV3 ARHGEF11 MED4 ARHGEF12 MED6 MED7 PRKCQ MAML3 CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 NKX2-5 ARHGEF7 SOS2 NGEF KALRN RET RARG ASH2L TFAP2A TFAP2B TFAP2C UBE2I TNKS1BP1 SUMO1 TEAD1 TEAD2 TEAD4 HIF3A ELOB TCF12 ELOC RBX1 RARB AJUBA EPAS1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C POLR2A PLXNA3 POLR2B LCE1A POLR2C LCE1B POLR2D LIPJ POLR2E LIPN POLR2F LIPM POLR2G PRSS8 POLR2H LIPK POLR2I POLR2J KRT4 POLR2K KRT3 POLR2L KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ACTB LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL CSNK2A1 KRT33B KRTAP5-10 KRT33A CSNK2A2 KRTAP5-11 SPRR2A SPRR2B SPRR2D CSNK2B ST14 CDSN KRTAP16-1 KRTAP8-1 TP53 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 SOX17 KRT27 SRY KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 ABL1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 PLAC8 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A PLXNA4 MAP2K6 KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B CNOT4 KRTAP2-4 CDK8 KRTAP2-3 KRTAP2-2 CNOT6 KRTAP2-1 CNOT7 KRT13 KLK13 CDK5 CNOT1 KRT12 KLK14 CNOT2 CNOT3 KRT10 LCE3E KLK12 KRT19 CNOT8 KRT18 KRT17 CNOT9 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 WDR5 KRT6C KRT6B RPTN ZNF521 KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 KRT76 SMARCD1 KRT75 SMARCD2 KRT74 SMARCD3 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 RBBP4 KRTAP23-1 RBBP5 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PTPRC LELP1 RBBP7 KRTAP4-1 ACTG1 KRTAP12-1 KRTAP12-3 KRTAP12-2 SMARCE1 KRTAP4-9 KRTAP4-8 KRTAP12-4 KLF4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 PFN1 KRTAP11-1 CELA2A SOX2 PFN2 KRTAP5-9 KRTAP5-8 KRTAP5-7 NFASC KRTAP5-6 KRTAP5-5 KRTAP5-4 SOX9 KRTAP19-2 KRTAP19-1 RUNX3 SRGAP2 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DIAPH1 DSG4 RPS27 KRT82 KRT81 ITGB1 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 RHOC KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 RHOA KRTAP6-3 RHOB KRTAP21-1 EVL SRF CDK5R1 CDC42 COX7A1 CLASP1 CLASP2 KDM5B ARID1A ARID1B TYROBP IFNG ERBB2 HES1 POMC MARK3 MMP9 NCBP1 NRP2 NCBP2 TLN1 CNTN2 NRCAM ANK1 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 FYN POU3F3 WNT4 MCM5 MCM2 CLTC CYP51A1 SREBF2 CLTA AP2A1 VLDLR AP2A2 CDON AP2M1 PBX1 RAP1GAP PRKACG PRKACA PRKACB CCL3 ANGPTL4 LPL AP2S1 CXCL12 DICER1 AP2B1 TRPM1 PAX3 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP LAMA5 LAMA2 SH3KBP1 PXN LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NUMB UCP1 MTA1 PRDM16 ZNF423 ENAH MTA3 RPS4Y2 EBF2 RPS27L BMP7 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 GMPR RPS3 MYO10 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 PPP3CB RPS25 MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 WNT11 NOTCH1 CACNA1D GCK NFATC1 NANOG HSP90AB1 RDX NAB1 NAB2 DNM2 SIAH1 EGR2 EPRS1 ID1 EIF4E ID4 EIF4B ZFPM2 EPHB6 EFNB2 ARHGAP39 EFNB1 EFNB3 EPHB2 EPHB1 ARHGAP35 EPHB4 EPHB3 ITGA10 FOXH1 ACVR1B WNT3A ACVR2B GIT1 ACVR2A DRAP1 ACVR1C DSG2 EPHA2 PAK1 ABL2 PAK2 PAK4 POU5F1 TGFB1 CNTN1 FOXC2 FOXC1 SIX1 HOXD11 NPNT HOXC11 HIRA PAX2 HOXA11 GREM1 SALL1 SIX2 DSCAM DCC DSCAML1 NTN1 STX1B TNFSF11 SRGAP3 SRGAP1 JUP FGFR1 WASL IAPP PAK6 PAK3 PAK5 MYO9B TPST2 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 SERPINE1 RPL4 RPL5 RPL30 RPL3 ITGA2 RPL32 RPL31 RPLP1 ITGA8 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 CTCF RPLP2 FABP4 HOXA3 RPL35 COL9A1 RPL38 HOXA1 PKNOX1 COL9A3 RPL37 PRL COL9A2 HOXA4 AGRN PIAS2 RPL39 RPL21 HOXB4 CHD3 RPL23 HOXB3 RPL22 HOXB2 HOXB1 RPL13A HOXD1 RPL9P9 HOXC4 RPL37A RPL24 MEIS1 RPL27 MAFB RPL26 HOXD4 HDAC2 DPF1 RPL29 HOXD3 RPL28 ZNF335 DPF2 RPL10 RPL12 DPF3 RPL11 RPL36A SUZ12 RPL14 PAXIP1 RPL13 RPL15 RPL18 RPL17 RPL19 PCGF2 RPL39L SS18L1 RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 CD36 NCOA2 SS18 NCOA6 NCOA3 TET3 SHH DHH ADIPOQ CREBBP EYA1 BCL2 NTN3 AREG CDH4 BNIP2 TNF CTNNA2 MYOG EBF1 WNT10B SPAG9 MEF2B NR2F2 MYOD1 ADIRF PAGR1 MYF6 SLC2A4 ZNF638 TCF4 BCL7A CEBPD CDH15 ZNF467 BCL7C MYF5 BCL7B FOXA1 KDM6A TGFA FOXO3 ABLIM1 ABLIM2 PTK2 ABLIM3 AKT3 JUN MED19 UHRF1 MED18 MED11 MED9 MED29 MED28 MED22 MED21 CDK19 MED13L ETF1 GSPT2 GSPT1 ASAH1 GSC MIXL1 UPF3A UPF2 UNC5A UNC5B CIDEA CAP2 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 MC4R DARS1 EEF1E1 MC3R KARS1 IARS1 PKP1 MC5R SDCBP DSP DSG1 DSG3 MAPK7 APH1A ZIC1 FOXD3 PSENEN NCSTN TFE3 APH1B MITF CLTCL1 PSEN2 TFEC ADAM10 ALX3 TBX3 PSEN1 DNM1 SDC2 STT3B GPC1 MAG PRDM14 CRIPTO SHC3 LIN28A ZIC3 ZSCAN10 DNM3 MAPK12 GATA3 LYN SIAH2 RPLP0 PITPNA CFL1 STAT4 IL12RB2 ACTL6A MSN PIK3CD KAT2B KAT2A MEF2A FGF8 RPS6KA3 SOX1 GBX2 RPS6KA5 RPS6KA2 OTX2 TBX6 RPS6KA1 POU3F1 YY1 ITGA1 LEFTY1 CRIPTO3 ONECUT3 DAND5 ONECUT1 CFC1 CER1 PDX1 NKX6-1 NODAL PTF1A PAX6 ISL1 PTGDS FOXO4 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD1 SMAD4 SMAD3 NEUROG3 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 USP33 SNAI2 FOXA2 NEUROD1 NKX2-2 PAX4 HNF1A MAFA RFX6 INSM1 FOXA3 FARP2 PLXND1 PKP4 PLXNA1 IRS2 PIK3CB PLXNB1 FGF2 NCK2 FGF4 NCK1 FGF7 MESP1 FGF9 AKT2 GATA6 TBXT GRB10 ATP6V1E1 TBX20 SMYD1 TBX1 EOMES HRAS ATP6V1G1 MYOCD HAND1 ATP6V0B ATP6V0E1 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 HNRNPU SPTBN1 ATP6V0D1 SOS1 ATP6V0C MAGOH ATP6V1A SHC1 PIK3R2 PIK3R1 INS NRAS ATP6V1H MAPK1 ATP6V1C1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 FGF10 UPF3B MAGOHB SNW1 SRC RNPS1 SHANK3 GRIN2B THRAP3 GRIN1 RND1 DLG1 DLG3 TBPL2 DLG4 MBP EMX2 FAM120B ADGRV1 PCDH19 DOCK1 WFDC2 MECOM MSX1 MPZ OSR1 PLK1 ADGRG6 ZIC2 HMGCR TBX21 SALL4 CCNB1 HOXA6 PAX8 PAX7 AMH GDF1 PRX NOG CTNNA1 DMRT1 NOTO PMP22 FOXF1 SOX10 BRCA1 ZEB2 CASC3 SNAI1 RANBP9 KAT5 GXYLT2 CDH2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP CEACAM1 ZEB1 DCT IRF4 SEM1 PXDN BIRC7 BCL2A1 TYRP1 MLANA USF1 MLPH RBM8A CXCR4 EDNRB KIF4B KIF4A CAP1 EDN1 EDN3 LEFTY2 PABPN1 PI3 CAPNS1 CAPN1 SCD5 ELOVL3 KIT BMP4 TCF7L2 CDKN1A ALCAM TCF7L1 SCN11A HDAC1 HOXA2 CDKN2A UNC5C LEF1 UNC5D TCF7 CDC25B SCN10A AGAP2 TBX2 FLRT3 HINT1 CCND1 CHL1 LYPLA2 SIN3A ZSWIM8 CDK2 MSI1 CTNNB1 COL6A2 MET PLXNC1 SEMA6A COL4A4 SEMA6D CEBPB SEMA7A COL6A1 GPR143 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 LHX4 COL6A3 LHX9 RBPJ CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB TNRC6C COL6A5 MOV10 NTN4 STX1A SEMA3E MEF2C AGO3 SEMA4A AGO4 NELL2 CDH1 RPS6KA4 SCN1B MYC AGO1 SCN1A AGO2 EPHA5 EPHA4 TNRC6A EPHA7 TNRC6B EPHA6 YWHAB EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 XPO1 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B AKT1 SCN3A PSMD1 PRNP SPTBN2 GATA4 ARTN CD24 SCN2A SCN2B PRKCA ROBO2 YWHAZ GFRA1 PSMA5 GFRA3 PPARGC1A PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 RGMA PPARGC1B PSMA1 GFRA4 RELN PSMA2 CD72 SCN9A PABPC1 NRTN DOK2 UBA52 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C EFNA5 PSMD13 EFNA4 SPTA1 EZH2 PSMA7 CACNA1S PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX MED16 PSMB2 SCN4A MED15 PSMB3 SCN4B MED17 SLIT1 SCN7A UBC MED12 PSMB1 SLIT3 MED14 PDLIM7 MED13 RPS27A HEY1 MED10 HSPA8 HEY2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 CACNA1H PSMC2 MYL12A MED27 SIRT1 CACNA1G MED26 CACNA1I EIF4G1 MED23 MED25 MED24 MED20 PPARG PPARA DRP2 FURIN PCSK6 ROCK1 ROCK2 UTRN MBD3 GATAD2B GATAD2A NCAN RPS6KA6 HSP90AA1 EGF EGFR PLCG1 CCND3 E2F1 TFDP1 TFDP2 CDK4 KMT2D H2AX CSF3R SPI1 GFI1 LIG1 H2AB1 DLX5 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 FOXO1 DOK1 MYB EP300 IL6R RASA1 H3-3B H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 BTG4 RUNX1 EIF4A2 H2BC12 H2BC13 KDM5A EIF4A1 H2BC14 TUT7 H2AJ TUT4 H2BC15 DUX4 TAL1 H2BC11 PABPN1L RARA TPRXL DUXA CEBPA KMT2A DUXB DIS3L2 CBFB CEBPE KDM6B GATA2 PRM2 H3C15 PRM1 RXRA STPG4 H2BC9 METTL23 H2AZ2 DPPA4 DPPA3 H4C9 H2BC8 DPPA2 H2BC5 ZFP36L2 H2BC3 LEUTX STAT3 PAIP1 NPM2 H2BC1 NFKB1 KDM4E DEK FLI1 TPRX1 AICDA KLF5 H2AC20 SRPK1 H1-8 TPRX2 HDAC3 ZSCAN4 TBL1X PCK1 NCOA1 NCOR2 NCOR1 HAND2 TBL1XR1 SLIT2 PLIN1 ROBO1 SEMA5A AKAP5 TBX5 CACNG8 CACNG2 CACNG3 CACNG4 TRIM33 SMARCB1 CCNC SMARCC1 SMARCC2 HELZ2 CHD9 ST8SIA4 TFEB SH3GL2 WWTR1 YES1 TGS1 MEF2D SMARCA2 SMARCA4 ST8SIA2 HNF4G DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 MAN1B1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR SOS1 HBEGF SHC1 ARHGEF7 PIK3R1 NRAS STAM2 ADAM10 ADAM12 PTPRK EPS15L1 EPN1 PTPN11 SPRY1 PTPN3 CDC42 FAM83B ADAM17 SRC LRIG1 SH3KBP1 PXN EGF CBL EGFR UBA52 PLCG1 STAM CSK HGS PTPN12 UBB PAG1 UBC RPS27A FAM83D SH3GL3 AREG FAM83A EPS15 SH3GL2 SH3GL1 AAMP SPRY2 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV GYG2 GBE1 GYS2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication ORC4 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 CCNB1 RB1 CDK1 PPP2R3B E2F1 MCM8 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B ORC5 POLA2 PPP2R1A NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway RXRA NR5A1 NR2C2 PPARD NR2C1 NR2C2AP RXRG NR2F1 NR0B2 NR2F6 NR1D2 RXRB NR1D1 ESRRA RARG ESRRB ESRRG NR1H2 NCOR2 NCOR1 ESR1 VDR ESR2 HNF4A MED1 NR4A2 NR4A1 RORC THRB RORA THRA RORB NRBP1 HNF4G NR2E1 RARB RARA PGR PPARG AR PPARA RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME SLC29A1 ADK SLC29A3 NME1 NT5C2 SLC28A3 NME2 PNP ITPA ADA SLC28A2 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PLD6 PLD2 PLD1 PLD3 PGS1 CDS2 PTPMT1 PLD4 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle FAM169A ADD3 AKAP12 SNAP23 VANGL1 ARHGAP1 ARHGAP32 SLC4A7 ARHGAP39 PIK3R2 ARHGAP5 PIK3R1 RHOF ESYT1 SYDE1 BAIAP2L1 ACTN1 POTEE LMNB1 TMPO BASP1 ACTB TOR1AIP1 ARHGAP12 DEPDC1B CAPZB VAMP3 RAB7A STEAP3 DIAPH2 ARHGAP21 SOWAHC FARP1 MYO9B SRGAP2 MTMR1 BAIAP2L2 SENP1 DIAPH1 DIAPH3 CAV1 MCAM DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology ASH2L NCOR2 NCOR1 TBL1XR1 HDAC1 HDAC3 CAMK4 GPS2 SIN3A RBBP5 PRKACA DPY30 TBL1X WDR5 CALM1 KMT2D IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly UQCRFS1 BCS1L UQCRH LETM1 TTC19 UQCRHL FXN LYRM4 HSCB LYRM7 UQCRC1 UQCRC2 UQCC3 UQCC2 UQCC1 CYC1 UQCC6 UQCC5 UQCR11 UQCR10 UQCRQ HSPA9 UQCRB MT-CYB RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 RRN3 CBX3 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 MBD4 MPG SMUG1 OGG1 NTHL1 APEX1 TDG REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 HEYL SPCS3 SPCS2 SPCS1 ANGPTL4 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRDM8 CTNND1 UBA52 BHLHE22 CDH8 PSMD12 ZC3H12A PSMD11 CTNNA1 PSMD14 CDH24 HOXC8 PSMD13 FOXF1 CSNK2A3 ADAM33 SOX10 EZH2 PCSK7 PSMA7 ADAM19 ILF3 PSMB6 MPHOSPH8 ZEB2 CDH11 PSMB7 SNAI1 CDH19 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity NR3C1 ESRRA STAT1 NKX3-2 MSX2 ESR1 SMURF1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B PSMA5 STUB1 PSMA6 PPARGC1A PSMA3 PSMA4 PSMA1 PPARGC1B PSMA2 UBA52 PSMD12 PSMD11 PSMD14 WWP1 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DLX5 PSMB1 DLX6 RPS27A HIVEP3 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TWIST1 CBFB CUL1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT GPAA1 PLAUR PIGK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 TPMT MTR AS3MT MAT1A NNMT MTRR COMT CYP1A2 MAT2B HEMK2 MAT2A GSTO1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle APBA1 SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 CASK LIN7A LIN7C LIN7B TSPOAP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L POLRMT GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB AJUBA ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ACTB ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ANG AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 PSIP1 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 GTF3C1 ARID1A GTF3C2 ARID1B GTF3C3 RBL2 GTF3C4 RBL1 CRCP IFNG GTF3C5 ZNF197 GTF3C6 ZNF195 BRF1 NR2C2 POLR3GL NR2C1 POLR3A THBS1 POLR3B HSPD1 VEGFA POLR3C ERBB2 POLR3D HES1 GLS2 POLR3E ZNF189 POLR3F ZNF286A POLR3G ZNF184 POLR3H ZNF180 BDP1 OPRK1 GLS POLR3K ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 BCDIN3D CDK9 TCEA1 XPO5 DROSHA JAG1 MTERF1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ANGPTL4 LPL TSNAX PRKRA DICER1 TARBP2 TSN SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A TRPC3 MTA1 MTA3 ELAC2 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAN LBR CAV1 TGFB1 STEAP3 ITGA2B TDG ITGA5 SERPINE1 LIPE DGAT2 FABP4 CHD3 BMI1 LPIN1 SUMO2 MGLL RING1 RRP8 HDAC4 SAP130 HDAC2 DPF1 L3MBTL2 PDK4 DPF2 SATB2 KAT8 RNF2 DPF3 SAP30BP HCFC2 SUZ12 WDR82 CBX8 PAXIP1 PHC2 PEX11A PHC1 BAZ2A CBX5 KAT14 CBX4 PCGF2 SETDB1 SS18L1 CBX2 SMARCA5 PHC3 ZZZ3 GSK3B TADA2A ZNF816 EZH1 AXIN1 PHF1 SUV39H1 GPI SGF29 CD36 CDC73 JARID2 NCOA2 SS18 NCOA6 NCOA3 TET2 SKIC8 TET1 PPHLN1 BAZ1B PHF20L1 CTR9 RTF1 NR5A2 AEBP2 MTF2 TET3 LEO1 PLIN4 PAF1 PLIN2 MBD2 MYBBP1A MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 SP1 TASOR MBIP TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C BCL7B CAMK4 DNMT3B UBTF BDNF ZNF765 KDM6A TGFA DNMT3A FOS POLR1A FOXO3 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H AKT3 C19orf84 JUN ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP ERCC6 RRN3 CIDEC HCFC1 AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X MCRS1 YY1 USP7 NFIX SSB USP2 NFIA NFIB NFIC FOXO4 ATXN3 SUDS3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 TADA3 MDM2 MDM4 OGT PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 TFAM TFB2M CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP PLD6 MAPK1 CAVIN1 CSTF3 CSTF2 DDX4 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S SF3B1 CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 IPO8 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 MTREX RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 PIWIL2 TDRKH SNRPB SRSF9 PIWIL1 HENMT1 RBM8A ASZ1 MAEL MOV10L1 MYBL1 CPSF4 TDRD9 CHTOP TDRD6 TDRD1 TDRD12 CPSF1 FKBP6 ALYREF CPSF3 CPSF2 YBX1 RBM7 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SAP18 MORC2 GTF2A1 GTF2A2 GTF2B ACSL1 ELOVL5 GTF2E1 GTF2E2 KIT SCD TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 HSP90AA1 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 CEBPA KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L NCOA1 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 PLIN1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 PCBP4 TP53 CDKN1A ZNF385A MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation MT-ND6 COX5B MRPS10 COX5A MT-ND5 MT-ND2 MRPL32 MT-ND1 ECI1 PCCB SUCLG2 UQCRC2 PRKACA MRPS2 OGDH MT-ATP6 STAR FH SHMT2 TRIAP1 ATP5PF ATP5PD MRPL12 MDH2 ATP5F1C ATP5PO NDUFA13 SLC25A5 SLC25A6 HSD17B10 SPG7 AFG3L2 SMDT1 YME1L1 PMPCA NDUFV3 ATP5MG MICU2 NDUFV1 STARD7 IDH2 UQCRQ TFAM HADH OMA1 OPA1 ALDH1B1 ME2 IDH3A BDH1 OXCT1 HMGCS2 PRELID1 ACAT1 NDUFS1 CHCHD2 NDUFB6 COX4I1 IARS2 ARG2 MT-CO1 HTRA2 ECH1 ACOT2 NDUFA2 LONP1 TWNK SSBP1 LDHD MT-CO2 NDUFS3 CS HSPD1 ACO2 PDHB GLUD1 TIMM17A PDK1 PDHA1 TIMM22 HSPA9 OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 ALAS1 TIMM9 TIMM10 ATP5F1A ALDH2 ATP5F1B DBT DLD PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy SQSTM1 UBC MAP1LC3B PEX5 NBR1 RPS27A ATM EPAS1 UBA52 USP30 UBB RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 NFKB1 NFKBIA DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP62 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 CDK1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C CCT2 TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBB6 TUBB3 CCT7 TUBB1 TUBA3D TUBA3C CCT8 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PXN TESK1 PARVA PARVB ARHGEF6 RSU1 LIMS1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 HBEGF EGF ERBB2 EGFR NRAS NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi CHST8 B4GALT4 CGA FUT8 MAN2A1 MGAT5 MGAT2 FUCA1 MGAT3 MGAT4C CHST10 B4GALT6 B4GALT5 MAN2A2 ST3GAL4 MGAT4A LHB MGAT4B B4GALT1 ST8SIA6 FUT3 ST8SIA2 B4GALT2 B4GALT3 ST8SIA3 ST6GAL1 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism MTMR3 MTMR8 MTMR9 PIK3R4 RAB14 PIK3R2 MTMR6 PIK3R1 MTMR7 PITPNB INPP5E PIP5K1A PIP5K1B GDE1 SACM1L ARF3 MTMR14 VAC14 PI4KA PI4K2B MTMR10 MTMR2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A FIG4 PIP4P1 INPP4B INPP5J INPP5K PIKFYVE INPP5F PI4K2A PTEN MTMR1 PIP5K1C TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 GDPD1 RAB4A GDPD3 GDPD5 RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PNPLA7 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 PNPLA6 INPPL1 RUFY1 TPTE ENPP6 SBF1 PIK3CA PIK3R3 SBF2 TPTE2 PIK3C3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated APC MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle SLC25A11 MDH1 GOT1 MDH2 SLC25A12 SLC25A18 GOT2 SLC25A13 SLC25A22 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX9 MYD88 NFKB2 RELA NFKB1 IRF7 DHX36 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation RPS2 METTL21A KIN METTL22 HSPA8 EEF2KMT VCPKMT ETFBKMT EEF1AKMT2 EEF1AKMT1 EEF2 EEF1A1 CAMKMT VCP PRMT3 CALM1 ETFB TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 SLBP NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass PCNA UBA52 NPLOC4 POLH WDR48 USP10 RAD18 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL UBA7 RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2L6 TRIM25 UBE2B POLE2 POLE3 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KCNK12 KCNK15 FXYD4 FXYD3 FXYD2 DMPK FXYD1 FXYD7 FXYD6 MME ATP2B4 NPR1 RYR1 ATP2B3 NPR2 RYR2 ATP2B2 NPPC RYR3 ATP2B1 TRPC1 CORIN CES1 SLC8A3 CLIC2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 ATP1A4 CACNG6 ATP1A3 CACNG7 ATP1A2 TNNI3 ATP1A1 KCNIP1 KCNIP2 KCNIP4 KCNK6 RANGRF KCNK7 PLN KCNK1 KCNIP3 FKBP1B CACNA2D2 CACNB2 NKX2-5 SCN11A SCN10A CACNB1 SCN1B CAMK2B SCN1A CAMK2D CAMK2A KCNH2 TBX5 SCN3B SCN3A KCNK10 CACNG8 GATA4 CALM1 KCNK13 SCN2A CAMK2G KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 CACNG4 KCNJ2 KCNJ4 SCN9A KCNK9 SCN8A KCNJ12 CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A SCN4A KCNA5 SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 WWTR1 AHCYL1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors GPR31 FFAR4 FFAR1 FFAR3 FFAR2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PI4KB PIK3C2A PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2A ARF1 INPP5E TPTE SACM1L ARF3 OCRL TPTE2 PIK3C3 VAC14 PI4KA INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins KCNQ2 KCNQ3 SCN9A SCN11A SCN10A SCN8A SPTAN1 SPTA1 SCN5A SCN4A SCN4B SCN7A NRCAM SPTB ANK1 SCN1B SCN1A NFASC ANK2 ANK3 SPTBN4 SPTBN5 SCN3B SCN3A SPTBN2 SPTBN1 L1CAM SCN2A SCN2B CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 ERBIN HRAS SOS1 HSP90AA1 SHC1 ERBB2 CDC37 NRAS PTPN12 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN NCSTN APH1B PSEN2 PSEN1 YBX1 NOTCH3 APH1A ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage MAPDA GMPR2 ADK AMPD1 TK1 GMPR AMPD2 CDA AMPD3 DCK APRT DGUOK PNP HPRT1 ADA UCKL1 UCK2 UCK1 PUDP TK2 UPP2 UPP1 TYMP TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC26A2 SLC22A5 ABCB6 SLC24A2 ABCB4 SLC24A3 KCNJ11 SLC41A2 SEL1L SLC5A1 SLC41A1 SLC5A2 SLC30A10 ABCC9 ADCY9 SLC39A6 SLCO1B1 SLC39A5 SLCO1B3 ERLIN1 ADCY4 SLC39A8 ERLIN2 ADCY3 SLC39A7 CP ADCY2 SLC39A2 SLC6A5 ADCY1 SLC39A1 ADCY8 SLC39A3 SLC2A9 ADCY7 SLC26A4 SLC30A8 ADCY6 RNF185 SLC30A3 ADCY5 SLC26A3 SLC30A2 SLC31A1 SLC30A5 SLC40A1 SLC39A10 SLC2A1 ATP2A3 SLC30A1 SLC2A2 ATP2A2 SLC6A2 SLC39A14 ATP2A1 SLC6A3 SLC8B1 SLC8A1 SLC8A2 SLC22A12 HEPH ABCC2 SLC2A10 ABCC6 AVPR2 SLC24A4 SLC16A7 DERL3 SLC16A8 DERL1 EMB DERL2 SLC16A3 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 RHAG SLC24A5 APOB ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 GNAS RAB11A SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 NEDD4L ADD1 TUSC3 MAGT1 ZDHHC8 SLC46A1 SLC5A5 VDAC3 VDAC2 VDAC1 CFTR SLC32A1 SLC6A13 SLC6A1 ARF1 WWP1 CYB5R2 CYB5R4 CYB5RL SLCO1A2 NEDD8 ARL2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 VCP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SLCO4C1 HMOX2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 LETM1 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC6A7 ATP6V0B PLEKHA8 ATP6V0E1 ATP6V1G2 ATP6AP1 SLC6A11 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ABCG2 ATP6V0A2 SGK1 HBB ATP6V1H SLC6A4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 SLC17A7 ABCA3 ABCC3 CAMK2B ABCC1 CAMK2D ABCD3 CAMK2A SLC2A3 CALM1 CAMK2G ADD3 SLC4A7 PHB1 SLC25A10 CAND1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SEM1 SLC4A2 SLC4A3 SLC4A5 SLC5A8 SKP1 SLC5A9 TFR2 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A12 NIPA1 CUL1 NIPA2 CLTC SLCO4A1 SLC17A1 HDLBP RHBG PCSK9 CLTA DMTN SLCO2B1 AP2A1 SLC26A11 VLDLR LIPA SLC16A2 RHCG AP2A2 LIPC SLC26A1 CREB3L3 SLC15A1 IREB2 LIPG SLC14A1 CTNS LDLRAP1 SLC15A3 SLC14A2 AP2M1 SLC15A4 SLC4A10 CUBN CYBRD1 CYB5R1 PIP AMN SLC26A7 APOA2 ACO1 APOA1 SLC26A9 LSR SLC26A6 APOA4 PRKACG SLC25A1 APOA5 MB NPC1 RAF1 PRKACA SLC13A1 SOAT1 PRKACB SLC13A2 SOAT2 SLC13A3 NPC2 ANGPTL8 ATP7A SLC13A4 ANGPTL4 NGB SLCO1C1 LPA SLC47A2 CES3 TF CA1 SAR1B SLC47A1 SLC5A12 MTTP SLC5A10 LPL CA2 LMF2 SLC25A26 LMF1 LRRC8C CA4 LRRC8D APOF AP2S1 LRRC8A LRRC8B A2M LDLR SLC13A5 SLC11A1 GPIHBP1 LRRC8E GLTP FGF21 RSC1A1 MBTPS1 APOBR AHCYL2 APOC3 NIPAL4 NIPAL1 AP2B1 NIPAL2 TRPM1 NCEH1 ALB NIPAL3 TRPM2 P4HB AZGP1 TRPM7 SLC22A4 TRPM8 MBTPS2 SLC22A3 TRPM5 SLC22A6 TRPM6 SLC45A3 TRPM3 ANKH TRPM4 TRPC7 RAB11FIP2 ABCC4 TRPC5 SLC10A6 MCOLN3 MYO5B TRPC6 MRS2 AQP12A TRPA1 SLC22A15 AQP10 TRPC3 AQP8 SLC22A16 TRPC4 AQP9 SLC22A17 TRPC1 AQP6 SLC22A11 AQP7 SLC20A1 TRPV2 AQP4 SLC66A1 TRPV3 AQP5 FTMT TRPV1 MCOLN1 AQP2 ESYT3 MCOLN2 AQP3 ESYT2 AQP1 STEAP4 TRPC4AP MIP HFE TRPV6 MMGT1 TRPV4 AQP11 TRPV5 SLC2A6 SLC2A7 SLC2A8 PDZD11 GLRX3 CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 SLC35B3 LCN9 SLC35B2 STOML2 SLC27A1 MCUB LCN2 SLC35B4 SPG7 PHB2 SLC35D1 MAIP1 SLC35D2 LCN15 PARL AFG3L2 LCN12 SMDT1 SLC35A2 YME1L1 SLC35A3 PMPCB SLC33A1 SLC5A6 PMPCA ARL2BP MICU3 LCN1 MICU2 SLC29A4 MICU1 PRKAR1B SLC27A6 MCU PRKAR2B SLC28A2 PRKAR1A SLC29A1 PRKAR2A SLC2A13 SLC28A1 SLC29A3 SLC5A11 SLC5A3 SLC29A2 SLC28A3 SLC27A4 CYGB EIF2S2 EIF2S1 EIF2S3 PSMD8 PSMD6 HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 TFRC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 ABCA6 ABCD2 UBA52 AKAP1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 SLC6A9 PSMB7 SLC17A6 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 UBC ABCC5 PEX3 ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 SLC1A5 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 PEX19 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 FURIN BEST3 PCSK6 SLC9C2 BEST1 PCSK5 BEST4 ESYT1 SLN ATP11C SLC67A1 ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 STEAP3 ATP8B1 ATP4B ATP4A FXYD4 FXYD3 WNK1 FXYD2 WNK2 FXYD1 HBA2 WNK3 FXYD7 FXYD6 CUTC RYR1 RYR2 RYR3 UNC80 ATP7B CLIC2 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 SLC22A7 STOM SLC12A2 SLC12A4 RUNX1 SLC12A5 SLC12A7 FTH1 FTL SLC25A18 CETP SLC25A11 APOD APOE ABCA1 ABCG8 MYLIP SLC25A22 ABCG5 NR1H2 APOC4 NR1H3 APOC2 APOC1 ANGPTL3 ABCG1 SLC35C1 SLC24A1 SLC17A5 AVP SLC2A4 SLC35A1 SLC22A8 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling CREBBP RELA ICAM2 LYN ICAM3 RELB NFKB1 EP300 NRAS PAK1 PAK3 HRAS FYN PRKACG RAF1 PRKACA PRKACB PAK2 CD209 RPS6KA5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B RAD50 RAD51D BLM RAD51 MRE11 RAD51C BRCA1 BRCA2 RAD51AP1 WRN ATM BRIP1 DNA2 KAT5 EXO1 RBBP8 NBN MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DBT DLD VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 PCNA CDC6 HDAC1 DYRK1A CDK1 CDC25A E2F1 RBBP4 CDK2 TFDP1 CCNE2 TFDP2 LIN54 TOP2A LIN37 CCNE1 LIN9 MAX LIN52 MYC E2F4 E2F5 CCNA2 CCNA1 MYBL2 RBL2 RBL1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO6 FOXO3 FOXO1 RPS6KB2 AKT1 AKT2 FOXO4 NR4A1 AKT3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis RXRA SCD NR1H2 FASN NR1H3 RXRB NRIP1 ANGPTL3 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 HSP90B1 DDIT3 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25A PKMYT1 WEE1 CLSPN YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 CDC25C ABRAXAS1 TP53BP1 H2AX H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDC7 CDK2 CDC45 MDC1 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SFN YWHAZ PSMA5 PIAS4 PSMA6 PSMA3 PSMA4 BRCC3 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 BLM MRE11 PSMA7 BRCA1 BABAM1 PSMB6 BABAM2 PSMB7 WRN BRIP1 KAT5 PSMB4 EXO1 UIMC1 CHEK1 PSMB5 RBBP8 NBN UBB TOPBP1 PSMB2 ATRIP PSMB3 BARD1 UBC RFC5 RMI2 PSMB1 RFC3 GTSE1 RFC4 RPS27A RMI1 RFC2 TOP3A ADRM1 RPA1 HUS1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 RAD50 PSMC4 PSMC1 MCM7 PSMC2 MCM8 RPA3 RAD17 TP53 CCNB2 CCNA2 RAD1 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 ORC5 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription REST SRF NR3C1 KCNIP3 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling MET GAB1 PIK3R1 HGF PIK3CA G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint WEE1 CCNA2 CCNB2 CCNA1 CCNB1 CDK1 PKMYT1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells RELA MAP3K7 NFKB1 CHUK IKBKB CARD11 MALT1 NFKBIA PSMD8 PSMD6 PSMD7 PSMD2 REL NFKBIE PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PSMC5 PSMC6 PRKCB SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 RAB11FIP3 RAB8A ARF4 GBF1 PKD2 RAB3IP PKD1 RAB11A RHO CNGA2 CNGA4 EXOC8 EXOC7 CNGB1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG MTR MTRR INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 FZD2 APC FZD5 PPP2R5B WNT1 PPP2R5A FZD1 PPP2R5D PPP2R5C CSNK1G2 WNT3A LRP5 CTNNB1 LRP6 WNT8A WNT8B PPP2R1B PPP2R1A PPP2CA PPP2CB DVL1 DVL2 DVL3 AMER1 GSK3B CSNK1A1 CAV1 FRAT1 PPP2R5E AXIN1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT DHRS7B AGPS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins MUC13 B3GNT3 B3GNT5 B4GALT6 B4GALT5 GALNT12 ST6GALNAC2 C1GALT1C1 MUC12 ST6GAL1 MUC15 MUCL1 MUC3A MUC5AC MUC3B GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ST6GALNAC3 GALNT10 GALNT9 ST6GALNAC4 MUC1 GALNT8 MUC2 B3GNT9 QTGAL B3GNT8 B3GNT6 MUC7 GALNT1 CHST4 MUC4 GCNT1 MUC6 GCNT3 MUC16 GCNT4 GALNT3 GCNT7 MUC17 GALNT7 C1GALT1 GALNT6 MUC19 GALNT5 ST3GAL4 GALNT4 MUC5B A4GNT MUC20 GALNTL5 MUC21 GALNT2 GALNTL6 ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT4 B3GNT2 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL WDR83 SRC YWHAB HRAS IL17RD ARRB1 ARRB2 LAMTOR2 MAP2K1 MAP2K2 ITGB3 LAMTOR3 ITGA2B RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell DISP2 SCUBE2 SHH IHH DHH ADAM17 NOTUM GPC5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance KIFAP3 APOOL PRKACA KIF3B KIF3C ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 YWHAE CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 YWHAG RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 RAB11A ATAT1 TTC8 SOD2 CARM1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 MED1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 ACSS2 NR1D1 CHCHD3 PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 MEF2C PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 CCP110 MAPK12 TNPO1 HCFC1 PPARGC1A PPARGC1B CEP57 CETN2 CEP164 ACTR1A PCM1 NRF1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HSPA9 HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 ALAS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 HAUS7 CEP70 CEP72 CEP192 PCNT TUBA4A CEP76 CEP78 PLK4 ATP5F1A SIRT3 ATP5F1B ODF2 CEP152 NEDD1 ALMS1 MTX2 PPARA CEP41 CYCS CEP43 IFT172 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 CCT3 RPGRIP1L DMAC2L WDR35 IFT88 SMO TCP1 ESRRA KIF3A TTC21B WDR19 IFT122 MKS1 MT-ATP6 CCT8 CCT5 CCT4 CEP97 TUBB4B KIF17 TUBB4A ATP5PF ATP5PD ATP5PB ATP5F1C HSP90AA1 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 ATP5PO HDAC6 RHO CNGB1 PPP2R1A CPAP ATP5MC2 ATP5MC3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 TFAM TFB2M RXRA DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 SAMM50 PDE6D HDAC3 MTX1 MAPRE1 PAFAH1B1 TBL1X DYNC1I2 NCOA1 NCOR1 CLASP1 TBL1XR1 DYNC1H1 NDE1 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 CALM1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 NCOA2 NCOA6 CDK1 GLUD1 GLUD2 SIRT4 CRTC2 CRTC3 CRTC1 HELZ2 CREBBP CHD9 MICOS13 MICOS10 CHCHD6 MTERF1 RAB8A GABPA SIRT5 TGS1 PPRC1 MEF2D PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 TFB1M RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MRM3 RCC1L RPUSD4 NGRN DDX21 RPUSD3 NOP58 RPS4Y2 RPS27L RPS4Y1 TRMT10C PRORP RPS4X RPS15 ELAC2 RPS14 RPS17 HSD17B10 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction SOX17 POU5F1 FKBP6 SPAM1 LMNB1 CXCR4 PRDM1 PDPN FIGNL1 TEX12 TEX15 MSH4 MSH5 CD9 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B HVCN1 MND1 FIRRM REC8 SYCP3 STAG3 DMC1 PSMC3IP MLH3 CDK4 PRDM9 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L SPO11 H2BC21 SUN2 SUN1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 EOMES H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 NANOS3 CBFA2T2 H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 BMP4 H2BC1 POT1 TERF2IP H2AC20 NANOG HSPA2 CDK2 MLH1 B4GALT1 TFAP2C UBE2I CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 ZP3 ZP2 TET2 ZP4 BLM MRE11 BRCA1 BRCA2 RBBP8 NBN TOP3A RPA1 RPA2 RAD50 RAD51 RAD51C RPA3 ATM ATR DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN3 PAIP1 LSM5 LSM4 SKIC2 LSM3 LSM2 LSM7 LSM6 DDX6 LSM1 PATL1 CNOT4 EDC3 EDC4 CNOT6 DCP1B CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT11 DIS3 XRN1 SKIC8 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 CNOT6L EIF4A2 EIF4A1 DCP1A TUT7 TUT4 EIF4G1 HBS1L NT5C3B SKIC3 EIF4A3 DCPS PAN2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes IKBKB SQSTM1 UBC MYD88 RPS27A IRAK1 NGF TRAF6 UBA52 NGFR PRKCI UBB RIPK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription RBPJ MAML2 FCER2 MAML1 MAMLD1 HES1 MAML3 EP300 GZMB NOTCH2 HES5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPKAPK2 MAPK1 MAPK8 ATF1 MAPK3 ATF2 PPP2R1B PPP2R1A PPP2CA PPP2CB MEF2C MAPK9 MAPK14 MAPK11 MAPK10 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK HDAC1 H2AC20 ERCC6 MBD3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MTA2 RBBP4 MTA1 MYBBP1A MTA3 TTF1 RBBP7 ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP85 NUP62 NUP43 RCC1 RAN NDC1 SEC13 RANGAP1 UBE2I NUP155 NUP133 SUMO1 NUP93 NUP35 NUP54 NUP205 NUP37 POM121 NUP107 NUP188 KPNB1 TNPO1 NUP160 AHCTF1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere ACD LIG1 PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 BLM RPA3 WRN DNA2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 AKR1D1 CYP46A1 CYP27A1 CYP39A1 HSD3B7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 ANAPC4 NEK2 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 UBB UBC BUB3 RPS27A MAD2L1 ANAPC15 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation HPGDS GSTA3 GSTA1 GSTM4 AKR1A1 GSTT2 GSTT1 ESD GSTT2B GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 GSTZ1 GSTA5 GSTA4 GSTO1 CHAC1 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GSTA2 GGT3P GGT1 GCLM MGST3 MGST1 GSTP1 MGST2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance CLTC PCSK9 AP2S1 CLTA AP2A1 LDLR LIPA AP2A2 AP2B1 NCEH1 LDLRAP1 AP2M1 LSR APOB NPC1 SOAT1 SOAT2 NPC2 CES3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes ITGA5 PIEZO1 CACNA2D1 SPP1 CACNG7 GJA1 CACNA1H PANX1 HSPG2 CACNB2 AKT1 ITGB3 P2RX7 ITGB1 CACNB1 CACNB3 ITGAV SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants MAPK1 DUSP9 DUSP6 DUSP16 DUSP7 DUSP10 DUSP8 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis COQ9 COQ7 COQ6 COQ5 COQ2 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A STARD7 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN LAT2 SYK FYN BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs HPGD PTGS2 ALOX15 ALOX5 LTA4H PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis ADSS2 GART PAICS PFAS IMPDH1 ADSL IMPDH2 PPAT ATIC GMPS ADSS1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins JUN RELA IRAK1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A IL1B PELI1 MMP1 MMP2 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 MAPK8 SOCS1 IKBKB SQSTM1 MYD88 FCER2 CANX PTGS2 ALOX5 RBX1 SDC1 HIF1A SNAP25 GATA3 LYN INPP5D ARF1 RALA RPLP0 IL1RN PITPNA BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CSF1R MAP3K7 FPR1 MAP2K6 TCP1 BCL6 SMAD3 NFKBIA TAB1 TRAF2 TEC TRAF6 USP14 NOD1 ITGAM ITGB2 NOD2 IRS1 USP18 PPP2R1B IRS2 PPP2R1A PIK3CB FGF2 TNFRSF1B SOX2 TNIP2 PTPN13 INPPL1 TWIST1 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 SHC1 PPP2R5D PIK3R2 PIK3R1 RHOU ALOX15 MAPK1 BIRC5 CHUK MAPK3 PTPN11 CDC42 LIFR PPP2CA PPP2CB HNRNPF CASP1 OPRM1 IFNG MCL1 CD86 PTK2B CD80 VEGFA IL22 POMC CXCL1 NFKB2 JAK2 HNRNPA2B1 IL2RG MMP9 FBXW11 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B CCL3L3 CCR5 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 P4HB PRTN3 TIMP1 POU2F1 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FN1 BRWD1 BLNK BTRC S1PR1 JAK3 CD4 LCN2 STAT2 MMP3 IL23R IL13RA2 IL13RA1 IL4R IL23A CDKN1A FSCN1 NDN LIF NANOG IGHE OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 IL11 PIM1 IL19 IL16 IL17RE OSMR PSMD8 IL17RB PSMD6 HMOX1 IL31 IL17C PSMD7 IL11RA SOCS2 IL7 PSMD2 IL7R IFNL2 PSMD3 IFNL1 AKT1 IFNL3 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A UBE2V1 HSPA8 VAMP2 ICAM1 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 RAG2 RAG1 IL32 CASP3 IL34 IL1RL1 IL33 TGFB1 LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 RORC RORA TNFRSF1A HSP90AA1 CBL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 MAP2K1 HSP90B1 H3C15 STAT3 NFKB1 ITGAX FASLG IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs JOSD2 UBC RAD23A JOSD1 ATXN3L RPS27A VCP RAD23B PRKN UBA52 ATXN3 UBB SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT CLTC CLTB FZD7 WNT5B WNT5A ROR1 CLTA ROR2 AP2A1 PRICKLE1 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 PRKG2 AP2S1 ITPR1 ITPR2 AP2B1 ITPR3 WNT10A DPY30 WNT7B WNT7A BTRC PRKCB RAC1 WNT6 PPP3CA WNT2 PPP3CB GNAT2 PRKG1 PLCB3 WNT2B PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 WNT16 NFATC1 GNAO1 TCF7L2 TCF7L1 HDAC1 LEF1 PIP5K1B TCF7 CTNNB1 ASH2L TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 RSPO3 TNRC6A TNRC6B TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 VPS29 PSMD1 VPS35 WLS VPS26A TMED5 PRKCA TLE5 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SNX3 PSMA2 CSNK1G2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 SFRP1 PSMB5 CSNK1E SFRP2 WIF1 UBB PSMB2 SOST PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 MEN1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PRKCG GNG10 CHD8 GNG12 CAV1 CBY1 SOX3 GNG11 SOX17 GNG13 XIAP RNF146 SRY SOX6 GNB2 SOX7 SOX4 GNB1 BCL9L RUVBL1 CTNNBIP1 SOX13 MAP3K7 GNB4 USP8 PYGO1 GNB3 BCL9 PYGO2 GNB5 GNGT1 TLE4 TLE2 TLE1 GNGT2 CUL3 TNKS GNG3 SMURF2 GNG2 GNG5 GNG4 GNG7 GNG8 USP34 ARRB2 SCRIB VANGL2 WDR5 AXIN2 RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 LGR6 KLHL12 LGR5 WNT3 CCDC88C RSPO4 LGR4 DACT1 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B DAAM1 H2BC21 PFN1 EP300 PARD6A SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 H3C15 PPP2R5E FRAT2 H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 H2BC1 H2AC20 RHOA PPP2CA PPP2CB SMURF1 CAMK2A AMER1 CALM1 GSK3B CSNK1A1 AXIN1 APC PORCN CDC73 LEO1 KAT5 CTBP2 CTBP1 CREBBP TERT WNT10B WNT9B SEM1 SMARCA4 WNT4 TLE3 SKP1 CUL1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4 AGRN B3GALT6 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MBD3 GATAD2B GATAD2A CHD3 DPF1 HDAC2 DPF2 DPF3 CHD4 SS18L1 ARID1A ARID1B SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 SMARCC1 MTA1 SMARCC2 MTA3 RBBP7 ACTB SPOCD1 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 PIWIL4 H3-3B H3C8 H2AC8 DNMT3L H2AC6 BCL7A H2AC7 BCL7C H2BC17 BCL7B SMARCA2 H2BC12 SMARCA4 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 C19orf84 H3C15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 MBTPS1 HSP90B1 MBTPS2 DDIT3 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control VCP RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 TCF25 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 ZNF598 RPS27 RPS23 ANKZF1 ASCC2 KLHDC10 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling CRLF1 TYK2 CANX IL6ST JAK2 IL27RA EBI3 STAT3 JAK1 STAT1 IL27 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o DPM3 DPM1 DPM2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport SLC22A5 RSC1A1 SLC14A1 SLC14A2 SLC22A4 SLC67A1 SLC22A2 SLC22A3 SLC22A1 RUNX1 SLC22A15 SLC22A16 SLC47A2 SLC47A1 SLC25A26 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RELA NFKB1 BST2 NPM1 ITCH PCBP2 NLRP3 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 UBE2I MAVS TKFC YWHAB FKBP1A RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 YWHAQ PYCARD YWHAG YWHAH YWHAZ SFN PPIB TRAF3 TRAF6 UBA52 TLR7 IFIH1 RIPK3 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 TOMM70 UBB RPS17 RPS15A RPS16 RPS19 UBC SP1 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 BCL2L1 EP300 RPS13 RPS12 RPS9 RPS7 RPS8 PPIA IRAK2 RPS5 RPS6 PSMC6 RPSA RPS3A RUNX1 RPS26 EEF1A1 RPS25 RPS28 KPNA2 PDPK1 RPS29 RPS20 FAU RPS21 RPS24 PPIH RPS27 RPS23 PPIG CAV1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSME1 PSMB10 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMD9 PSMD4 PSMA5 PSMD5 PSMA6 PAAF1 PSMA3 PSMA4 PSME3 PSMA1 PSME4 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMD12 PSMG4 PSMD11 PSMG1 PSMG2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBC RPS27A CBL UBA52 MKNK1 SPRY2 MAPK1 MAPK3 BRAF PTPN11 UBB PPP2R1A BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors STAB2 APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 HSPH1 HYOU1 IGLV2-11 SCARF1 S100A9 IGLV1-40 APOB HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 HMGB1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 COL4A2 COL4A1 FTH1 PRDX1 SCGB3A2 MASP1 SPARC FTL V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 APOE V2-8 V1-20 CALR V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD36 LRP1 COL1A1 SSC5D COL1A2 STAB1 CD5L SAA1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CCL2 EDNRA CCL1 EDNRB CCL19 PROK2 CCR2 CCL17 AVPR2 PROK1 AVPR1A CCL16 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP NMS PDYN NMU AGTR2 FPR3 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 CCKAR PNOC SSTR3 EDN1 GPR37 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR MT-RNR2 INSL3 F2RL1 INSL5 PENK F2RL2 F2RL3 APLN GPR37L1 KEL PMCH NLN PPY MC1R GHSR MC4R F2R MC3R UTS2 GAL NTS MCHR2 NPB NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R NPY1R APLNR BDKRB2 BDKRB1 QRFPR XCL2 XCL1 PYY HEBP1 CCK GPER1 HCRTR2 HCRTR1 NPY5R KISS1 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 OPRD1 ACKR1 C5AR2 C5AR1 C5 AGT PF4 C3 FPR1 NPY CXCR1 CXCR2 OPRM1 SST OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling IL18RAP IL18R1 IL4 IL18BP IL13 IL18 IL37 ALOX5 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants HRAS NRAS KRAS ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins YWHAH SFN YWHAZ DYNLL1 DYNLL2 PPP3CC E2F1 BID TP63 PPP1R13B MAPK8 BCL2L11 TFDP1 TFDP2 BAD BBC3 BCL2 PMAIP1 AKT2 BMF YWHAB YWHAE TP73 TP53 AKT1 PPP3R1 TP53BP2 YWHAQ YWHAG AKT3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions PARD6G CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 PRKCI CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 PATJ CLDN18 CLDN17 CLDN16 PARD6A F11R CRB3 PARD6B PARD3 CLDN5 PALS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C S100A9 S100A8 YWHAE YWHAQ YWHAG YWHAH FLNA LIMK2 PRKCB RAC1 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 CTNNB1 CDH1 YWHAB MYL9 XPO1 CYFIP1 NCKAP1 PRKCD AR PRKCA NCF1 SFN YWHAZ NCF2 NCF4 CFTR BRK1 BTK CFL1 CYBB CYBA ACTB NOXO1 MEN1 MAPK14 MAPK11 PAK1 MYLK NCKAP1L WASF1 PAK2 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX3 ABL1 NOX1 ROCK1 ROCK2 WIPF1 WIPF2 CYFIP2 WIPF3 NUP107 LIN7B NUP160 CIT IQGAP1 NUP85 PKN3 IQGAP2 IQGAP3 NUP43 RANBP2 SEC13 GOPC CDC25C PKN2 NUP133 PKN1 CDKN1B NUP37 ERCC6L WASL ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 MRTFA KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 DAAM1 H2BC21 ZW10 NCK1 PFN1 WAS MAD1L1 PFN2 H3-3B CDCA8 H3C8 PRKCZ H2AC8 PMF1 SKA1 H2AC6 SKA2 PAK3 H2AC7 DSN1 H2BC17 WASF3 DVL1 DVL2 H2BC12 DVL3 H2BC13 SRGAP2 H2BC14 SCAI H2AJ RCC2 KTN1 PDPK1 H2BC15 NDC80 ZWINT H2BC11 DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PIK3C3 H3C15 PPP2R5E NUF2 KIF14 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 H2BC1 RHOC RANGAP1 RHOD H2AC20 CKAP5 DYNLL2 RHOQ RHOA RHOB KIF2A KDM1A MAPK1 INCENP PIN1 BIRC5 EVL KIF2C RTKN KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 MAPK3 CENPA AURKB NSL1 CENPC CDC42 PPP2CA RHPN1 PPP2CB RHPN2 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ DLG4 SPC24 CALM1 SPC25 MAD2L1 CENPS PLK1 NCOA2 CTNNA1 PPP1CB PPP1R12A PTK2 CLIP1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation MAPK1 SOS1 SHC1 INS MAPK3 GRB10 IRS1 INSR IRS2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) RPS6KA1 JUN H2BC9 H2AZ2 CXCL8 H4C9 VENTX H2BC8 RELA H2BC5 H2BC3 MAPK7 STAT3 H2BC1 CDKN1A NFKB1 CDKN2A H2AC20 MAPK1 CDK2 CEBPB MAPK3 EHMT2 EHMT1 IL6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDKN2D ANAPC11 CDKN2C CDC23 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 CDKN1B ANAPC4 ANAPC5 FZR1 ANAPC1 ANAPC2 IGFBP7 CDK6 IL1A CDK4 H2AX UBB H2AB1 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS CCNA2 CCNA1 H2BC11 RPS6KA3 RPS6KA2 H3C15 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription HOXC8 HEYL FOXF1 SP1 ILF3 ZEB2 SNAI1 PRDM8 BHLHE22 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses CGAS TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC TRIM21 STAT6 MRE11 NLRC3 IFI16 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling ADAR ARIH1 PPP2R5A STAT3 NPM1 HSPA1L DHX9 HSPA2 CHUK SPHK1 EIF2AK2 ISG15 MAP2K6 STAT1 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB FANCC PPP2CA PPP2CB PRKRA TARBP2 UBE2I MAVS SNCA SUMO1 DUS2 TRIM25 CENPS CENPX ILF2 CDK1 ILF3 IKBKG PPP2R1B PPP2R1A PTPN2 DNAJC3 NCK1 FAAP100 FAAP24 HSPA8 FAAP20 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A TP53 UBE2L6 HERC5 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF10 FGF2 EGF FGF4 FGF7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LMF1 GPIHBP1 FGF21 MBTPS1 FURIN PCSK6 LIPC CREB3L3 APOC2 PCSK5 ANGPTL3 MBTPS2 APOA4 APOA5 ANGPTL8 ANGPTL4 LPL LMF2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response XIAP CARD8 CYCS UACA BAK1 CDKN2A GSDMD GSDME BAX MAPK1 C1QBP AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance PCNA RUVBL1 NPM1 WRAP53 PIF1 GAR1 CTC1 CENPW CENPX RUVBL2 OIP5 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 RBBP4 RTEL1 CHTF8 DAXX ATRX RSF1 RBBP7 PRIM2 MIS18A PRIM1 POLA1 H2AX DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 KNL1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC1 H3-3B STN1 TEN1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 CDK2 ITGB3BP CENPA CENPC FEN1 CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L BLM WRN HJURP RFC5 RFC3 RFC4 TERT RFC2 RPA1 MIS18BP1 RPA2 RPA3 CCNA2 CCNA1 DNA2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors PIAS4 PIAS3 TFAP2B SUMO3 SUMO2 TFAP2C UBE2I PIAS1 CDKN2A SUMO1 MDM2 FOXL2 MITF HIC1 SP3 MTA1 TP53BP1 TP53 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3 CRIPTO DPPA4 ZIC3 EPHA1 FGF2 SALL4 STAT3 SOX2 POU5F1 NANOG SALL1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B2 SRD5A3 HSD3B1 CGA LHB HSD17B3 HSD17B12 SRD5A2 CYP17A1 SRD5A1 POMC SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 RXRA APH1A TGFB1 GIPC1 TGFBR1 PSENEN TGFBR2 NCSTN APH1B PSEN2 PSEN1 ACVR2A INHBA INHA TGFB2 SP1 TIMP2 FGF2 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B TIMP1 MYF5 TCF3 HELLS TCF12 KLF16 ARRB1 ARRB2 RARA MMP14 MMP16 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression TP53 PRDM1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 GP9 ADAMTS13 VWF GP1BA GP1BB AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation NTRK1 PIK3CB PIK3R2 PIK3R1 NGF PIK3CA IRS1 RHOA IRS2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 H2BC1 LIG4 MDC1 PAXIP1 RNF168 NSD2 PIAS4 BRCC3 PRKDC MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN BARD1 H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2BC15 DCLRE1C RIF1 H2BC11 ATM POLL NHEJ1 POLM TDP2 TDP1 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy CETN1 PARK7 UBC DYNC1LI1 CFTR RPS27A DYNC1I1 HSP90AA1 DYNC1LI2 DYNLL1 UBE2V1 PRKN DYNC1H1 UBA52 ARL13B DYNLL2 HDAC6 PCNT HSF1 VCP IFT88 DYNC1I2 UBE2N UBB RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter CRCP TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 POLR1C POLR1D INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease RELA ARPC1B NPM1 ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 NR3C1 IRAK1 NCKIPSD IL6 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 VAV3 MED4 MED6 MED7 UBE2N VAV1 VAV2 MAPKAP1 NEDD4L C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 V1-11 PTGES3 V1-16 V1-13 MAPK8 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB V2-8 V1-20 V1-9 TAF7L V5-4 FEN1 V1-7 V5-1 V1-5 UBE2I V1-3 V5-6 SUMO1 C1QA C1S UBE2D2 ELOB V4-6 ELOC V4-2 RBX1 V4-1 VHL RNMT CCNH POLR2A ISCU SNAP25 POLR2B POLR2C POLR2D SYT1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 GNG10 GNG12 GNG11 GNG13 KPNA7 KPNA4 GNB2 KPNA5 GNB1 GBP1 KPNA3 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 CDK8 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 ACTG1 PPP1CC TXNRD1 PML DYNC1LI1 DYNC1LI2 FCGR2A DVL1 DVL2 DVL3 TXN RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 HBB CD33 CHUK TJP1 DYNC1I2 CDC42 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X NFKB2 JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 PRKACG IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 FCGR3A BRD4 RPS18 CRBN RPS3 MYH2 MYO10 IGLC7 RPS2 IGHV3-53 MYO1C RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 PRKAR1B RPS5 PRKAR2B RPS6 PRKAR1A RPSA PRKAR2A RPS3A PRKX RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HBEGF HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E RNF213 ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A GBP2 GBP4 TLR6 IKBKE IRF7 CYFIP1 NCKAP1 BRK1 RAN NEK2 PDIA3 TUBB CYBA VPS36 VPS25 CBX1 SNF8 CHMP1A RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L SUGT1 WASF1 PAK2 IGF1R WASF2 CALM3 CALM2 CAV1 BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A WIPF1 WIPF2 FXYD4 WIPF3 FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 FCGR1A SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C DUSP16 TMPRSS2 WASL SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 NRP1 MAP2K1 MAP2K2 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 ENO1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 PGK1 ARID4B SAP30 MAP2K4 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD MAP2K7 TAB3 TAB2 NFKBIB ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 ARIH1 IFNA13 IFNA14 ADCY9 IFNA16 SAP30L IFNA17 ADCY4 BAG2 MED9 ADCY3 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 FGR GGT5 PATJ VPS39 VPS18 LARP1 ITPR1 VPS11 ITPR2 GGT1 VPS16 ITPR3 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 NOS2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 P2RX7 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 P2RX4 PARP8 TUFM GEMIN4 GEMIN5 CRK GEMIN6 GEMIN7 GNAS GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 GSDMD DNAJC10 NMT1 VPS33B RIPK3 CORO1A IL18 HGS IL1A RAB5A KPNB1 IL1B TLR4 BCAP31 FNTA CHMP4C UPK1A EPCAM CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 STAM RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IL10 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 AHCYL1 TAF9B KPNA2 MAP3K7 H2AC1 STAM2 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 GNAZ CD163 SMAD4 RHBDF2 ADORA2B SMAD3 ADAM17 NFKBIA SCAP MAVS CYFIP2 TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 WASF3 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 DPEP2 CRNKL1 CDC40 DPEP1 ATP6V1H MAPK1 DHX9 CSTF3 CSTF2 ELMO2 MAPK3 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D SRC RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 CALM1 DOCK2 CAMK2G HNRNPH2 DOCK1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CTSG CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 LTF TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 CD9 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 MET ACOT2 STX1A CDH1 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 C3 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B TRIM27 HSP90AA1 CBL EGFR PLCG1 RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 SFPQ IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 GNAI3 GNAI1 GNAI2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 SH3GL3 EPS15 SH3GL2 SH3GL1 ST3GAL1 ST3GAL2 ST3GAL3 YES1 EEF2 CTSL SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses RELA PPIB NFKB1 BST2 TRAF3 TRAF6 UBA52 ITCH TLR7 IFIH1 RIPK3 KPNB1 PCBP2 UBB TOMM70 NLRP3 UBC RPS27A TBK1 IRF3 NFKBIA STING1 MAVS IRAK2 PPIA TKFC FKBP1A RUNX1 RIGI RCAN3 KPNA2 NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 PPIH PPIG PYCARD PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A APOL1 COPS3 COPS6 HMGB1 COPS5 COPS8 PRDX1 CHMP3 CHMP6 CHMP7 PLA2G6 V2-11 V3-4 DCTN6 V3-3 DCTN5 V2-17 DCTN1 GJC1 V3-2 DCTN4 GJC2 V2-15 GJA3 V2-19 V1-11 GJA10 GJA5 CLTCL1 GJA4 V1-16 MAN2A1 GJA9 V1-13 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 V2-8 GJB5 V1-20 GJB7 CHM TMED2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 CD59 DNM3 CD55 V4-6 V4-2 V4-1 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 CD163 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 HP STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 HBB TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 APOA1 COG8 COG7 COG6 COG5 COG4 IGHV3-23 COG3 RAB27B COG2 COG1 IGLV RINT1 RAB30 IGLV2-8 RAB36 IGKV1-16 TF KIF16B IGKV1-17 SAR1B KDELR2 IGKV1-12 KIF20B IGHV3-7 COPB2 IGHV3-9 COPA IGHV3-30 TMED10 ARL1 IGHV3-33 AP2S1 KIF3B AGTR1 IGKV1D-39 MAN2A2 VTI1A LDLR IGKV1D-33 SERPINA1 KIF3C RAB6B IGKV2D-28 RAB39A IGKV4-1 KIF18B IGHV7-81 KIF4B AP2B1 ALPP IGKV2D-30 KIF4A IGHV4-59 ALB COPE IGHV1-69 KIF12 KIF11 USE1 IGLV2-11 BICD1 S100A9 RABEPK IGLV1-40 BICD2 IGLV1-47 KIF15 KIF19 IGLV6-57 IGLV2-14 MAN1A2 F5 IGLV1-44 KIF13B F8 TMED3 KIF1C IGKV3-15 KIF1B IGKV3-11 IGKV2D-40 MAN1A1 IGHV3-11 KIF1A IGHV3-13 TMED7 TMED9 IGLV7-43 IGKV1D-16 NAA30 IGKV1D-12 KIF25 COPZ2 IGLV1-51 IGLV2-23 KIF22 STX4 KIF6 BET1L IGKV3-20 KIF27 COPZ1 SH3KBP1 SLC2A8 IGHV4-34 RAB33B IGHV1-2 KIF9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 CD3G IGHV NAA35 CD3D IGKV2-29 NAA38 VAMP4 IGKV2-28 PAFAH1B3 IGLC3 ARF5 NAPA NAPB IGLC1 NBAS CHRM2 IGLC2 TMF1 STX16 IGKV3D-20 STX18 GOSR1 GOLGA2 NAPG STX10 IGKV2-30 IGLV3-19 CYTH3 ARFRP1 IGHV2-70 IGHV2-5 CYTH2 IGLV3-1 CYTH4 IGHV3-48 CUX1 IGLV3-25 VPS51 CD4 IGLV3-27 VPS53 VPS52 IGKC IGKV1-39 MAN1C1 IGLV3-21 BNIP1 STX6 IGKV1-33 VPS54 CYTH1 RIC1 IGLC7 IGHV3-53 MYO1C GALNT2 ARCN1 IGKV5-2 RGP1 KIF26A IGLC6 IGKV1-5 KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB CALR PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A COL1A1 COL1A2 SSC5D STAB1 CD5L SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 STAB2 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 HSPH1 SNX2 FNBP1L HYOU1 SNX9 SNX5 SCARF1 TBC1D8B PUM1 HBA2 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 HSP90AA1 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 COLEC12 KIF20A MSR1 TMEM115 CNIH2 COLEC11 CNIH3 SCARA5 HSP90B1 MCFD2 MARCO MIA2 COL3A1 PPP6R1 COL4A2 COL4A1 TRAPPC6A FTH1 TRAPPC6B SCGB3A2 SEC22A SEC22C MASP1 FTL SPARC STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF APOE PLIN3 GGA2 GGA1 GGA3 CD36 LRP1 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 SAA1 TGFA HPR HPX IGHA1 IGHA2 EREG AMBP BTC JCHAIN EPGN AKT3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDC7 CDK2 CDC45 PRIM2 PRIM1 POLA1 POLA2 POLE MCM10 RPA1 DBF4 RPA2 RPA4 MCM7 MCM8 POLE4 GMNN RPA3 MCM3 MCM4 POLE2 MCM5 POLE3 MCM6 MCM2 ORC5 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle TRAK1 TRAK2 RHOT1 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SLBP LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants LRP5 KREMEN1 KREMEN2 DKK1 DKK2 DKK4 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade SERPING1 CFD C3 GZMM CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 CD81 C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S FCN1 C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC FCN2 FCN3 CRP COLEC10 PROS1 F2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription SGK1 NAB1 NAB2 LYL1 REST F3 ATF1 DNM2 SRF ARC TRIB1 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 SH3GL3 ID1 CDK5 VGF ID4 FOSB EP300 ID3 JUNB CDK5R2 MEF2D TCF12 FOS CHD4 ELK1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding OGG1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency NAGS TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway CREBBP TBK1 IRF3 TRAF3 EP300 MAVS RNF135 RIGI IFNB1 IFIH1 TRIM25 IKBKE TRIM4 IRF7 SIKE1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCD4 TCN2 CD320 LRP2 ABCC1 LDLRAP1 TCN1 LMBRD1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres ACD TINF2 PCNA TERF1 TERF2 RUVBL1 POT1 TERF2IP WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 BLM RTEL1 CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 RFC5 POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 CHTF18 RFC2 TERT RFC1 STN1 RPA1 TEN1 RPA2 RPA3 CCNA2 CCNA1 DNA2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GUSB SGSH GNS ARSB GALNS HGSNAT NAGLU HYAL1 GLB1 IDS IDUA DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm YAP1 SMAD2 SMAD3 TBXT LEF1 TCF7 TEAD2 NOTO TEAD4 FOXH1 FOXA1 CTNNB1 SHH FOXA2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D TBCE TUBA3C TUBA8 TUBA1C TUBA4B TUBA1B TUBA4A TUBA1A TUBB4B TUBB4A TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SLC24A2 SLC24A3 SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SRI CALM1 SLC24A5 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling XIAP RELA MAP3K7 NGF USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 NSMAF SMPD3 SMPD2 RIPK1 TBK1 IRAK1 ADAM17 NFKBIA TAB1 TAX1BP1 ARHGDIA YWHAE TNFAIP3 RNF31 SPATA2 TNFRSF1A OTUD1 UBE2L3 TRAF2 TNFSF10 TRAF6 PRDM4 FADD BIRC2 BEX3 BIRC3 CFLAR PRKCI USP21 TRIO RASGRF2 OTULIN ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 TRADD ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 CASP8 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN RACK1 TRAF1 ARHGEF3 ARHGEF4 ULK1 TNFRSF10B ARHGEF1 TNFRSF10A ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF TNFRSF10D ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 RBCK1 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 CHUK ECT2 ITGB3BP FAS ARHGEF33 FASLG NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 SHARPIN LINGO1 MAG OMG RTN4 HDAC2 UBE2D2 UBE2D3 IKBKE CASP2 STUB1 BAG4 UBE2D1 MAPKAPK2 UBA52 CYLD OTUD7B IKBKG UBB RIPK2 UBC RPS27A CASP10 TNF OPTN TAB3 TAB2 CASP3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 TASL HMGB1 CASP8 IRF5 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 TLR8 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling IL23R STAT3 IL23A RAP1B LMNB1 TCP1 CA1 STAT1 CDC42 CRLF1 CANX IL6ST IL27RA EBI3 HNRNPF IL27 P4HB SNRPA1 IFNG ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 JAK2 STAT4 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA PAK2 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP CTNNB1 IRF3 EP300 LRRFIP1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense SFN GBP1 CASP1 PIM1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation NR5A1 SRY SOX9 PTGDS DHH FGF9 WT1 AMH GATA4 DMRT1 ZFPM2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex PCNA MAX LIN52 CDC6 MYC HDAC1 E2F4 CDC25A E2F5 E2F1 RBBP4 TFDP1 TFDP2 LIN54 TOP2A LIN37 LIN9 RBL2 RBL1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB4 FGF2 THBS1 ITGB5 ITGA6 TNC TGFB1 VTN ACTN1 ITGA2 CASK SDC1 SDC4 ITGB3 ITGB1 SDC2 TRAPPC4 SDC3 ITGAV SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF BAIAP2 ABI2 ABI1 RICTOR ROCK1 ROCK2 PRKACG PRKACA PRKACB SPHK1 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 NOS3 PRR5 CRK PXN HSP90AA1 JUP PLCG1 SHB SH2D2A PIK3CB AXL NCK2 NCK1 RASA1 AKT2 PRKCZ PAK3 PRKCB RAC1 HRAS WASF3 BCAR1 VAV3 PDPK1 NRP1 PIK3CA ITGB3 VAV1 VAV2 TRIB3 MAPKAP1 ITGAV PIK3R2 PIK3R1 NRAS THEM4 RHOA CTNNB1 ELMO2 CDC42 MLST8 MTOR SHC2 HSPB1 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA FLT1 FLT4 NCF2 KDR NCF4 VEGFB PTK2B VEGFC VEGFD PGF BRK1 VEGFA MAPKAPK2 CTNND1 CTNNA1 CYBB CYBA MAPKAPK3 NRP2 CDH5 AAMP MAPK14 MAPK11 PAK1 AHCYL1 FYN NCKAP1L WASF1 PAK2 PTK2 WASF2 CAV1 AKT3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ARIH1 FURIN NPM1 OAS2 EIF2AK2 SPHK1 ISG15 MAP2K6 STAT1 FANCC PRKRA IRF3 TARBP2 MAVS RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 CENPX NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 FLNA PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 KPNB1 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B EIF4E2 FNTA FLNB MX2 DNAJC3 MX1 EIF4G3 EIF4G2 NCK1 EIF4A2 EIF4A1 UBE2L6 EIF4A3 HERC5 UBE2N ADAR PPP2R5A STAT3 HSPA1L DHX9 PIN1 HSPA2 CHUK MAPK3 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB PPP2CA PPP2CB EIF4E UBE2I SNCA GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 CASP1 NUP214 CENPS SFN ABCE1 UBE2E1 UBA52 CDK1 ILF3 JAK1 ACTB IKBKG UBB UBC PTPN2 RPS27A FAAP100 HSPA8 FAAP24 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation FGFR4 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B CHMP4A GABARAP CHMP2B CHMP2A UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A CHMP3 ATG12 ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B DYNLL2 TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 WIPI1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC25A10 SLC5A8 SLC5A12 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions COL4A2 COL18A1 COL4A1 ITGA5 ITGA3 ITGA9 COL16A1 ITGA1 ITGB8 COL13A1 ITGB5 ITGA6 JAM2 TNC JAM3 COMP IBSP SPP1 FBN1 ITGAX ITGB6 ITGA2 COL23A1 HSPG2 ITGA8 COL4A4 ITGA7 ITGAL COL4A3 VCAM1 LUM CD47 ITGA11 ITGA4 CD44 COL9A1 ITGAE COL9A3 PECAM1 COL9A2 AGRN ITGB7 CDH1 ITGAD KDR THBS1 FN1 VTN ITGA10 FGB FGA ITGAM ITGB2 FGG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 F11R BSG ITGB3 ITGB1 ITGA2B ITGAV PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening CACNB4 CACNG2 CACNA2D2 CACNG4 CACNA1B CACNA1A CACNA1E CACNB2 CACNA2D1 CACNA2D3 CACNB1 CACNB3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation FCGR1BP SEC61A2 SEC61A1 TIRAP TAPBP SEC22B B2M HLA-A TLR1 S100A9 PSMB10 S100A8 TLR2 FCGR1A STX4 CD14 TLR4 LY96 HMGB1 ITGAV HLA-H ITGB5 HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 CHUK LNPEP IKBKB MYD88 CD207 CALR CTSS MRC2 MRC1 VAMP8 PSMD8 PSMD6 TLR6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 NCF1 NCF2 PSMA5 NCF4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 CYBB FGA PSMB4 TAP2 CYBA FGG PSMB5 IKBKG TAP1 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSV CTSL FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGFBP3 FGFBP1 FGFBP2 FGF23 FGF22 FGF16 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis PCNA UBA52 POLH USP10 PCLAF USP43 REV1 ISG15 POLI UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling AKT2 PDE3B NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling OTUD5 ATG5 ATG12 UBE2D1 TRAF3 UBA52 UBE2K CYLD ITCH PIN1 IFIH1 ISG15 TRIM4 PCBP2 UBB UBC RPS27A NLRX1 TBK1 IRF3 NLRC5 UBA7 MAVS RNF125 RNF135 TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 UBE2L6 TRIM25 IKBKE HERC5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 CASP10 TP53 CASP6 ATM CASP1 CASP2 PIDD1 APAF1 NLRC4 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT6A CCT7 CCT4 CCT3 TCP1 ACTB CCT2 CCT8 CCT6B FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I POLR2J POLR2K POLR2L RBFOX2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 NCBP1 NCBP2 HNRNPA1 PTBP1 HNRNPM HNRNPF HNRNPH1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation PRKCB PRKCA STX4 PRKCG STXBP3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL11B SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A BCL7A DPF2 BCL7C BCL7B SMARCA4 SMARCC1 SMARCC2 ARID1A SMARCE1 ACTB RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling CREBBP RBPJ MAML2 MAML1 KAT2B KAT2A HES1 SNW1 EP300 JAG1 RUNX3 MAMLD1 MAML3 NOTCH1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand LIG1 PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression RXRA SP1 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B MYF5 TCF3 HELLS TCF12 KLF16 RARA SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM ADRM1 OAZ3 PAOX AZIN2 AZIN1 PSMC5 AGMAT PSMC6 SEM1 PSMC3 SMS PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNAT3 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 GNG12 GNG11 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A PIK3CA IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 PLD4 V2-19 V1-11 PLD3 V1-16 V1-13 PLD2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 PRKCD PLPP5 PLPP4 SYK AHCYL1 PRKCE DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses AP2A1 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 ARHGEF9 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 BCHE PRKCA SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT SLC6A1 CPLX1 RIMS1 ALDH5A1 DNAJC5 GIT1 HSPA8 VAMP2 CAMKK1 CAMKK2 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 SYN3 SYN2 HRAS SLC6A11 PDPK1 ARL6IP5 CACNA2D1 CACNA2D3 NRAS CHAT GRIP1 MAPK1 GNAT3 SLC6A4 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 SLC18A3 CHRNA1 CHRNA3 SLC17A7 CHRNA2 MAPK3 CHRNA5 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 GRIK4 GRIK1 GRIK2 GRIA1 GABRR3 CAMK2B GABRR2 GRIA2 GABRR1 CAMK2D NPTN SRC ACTN2 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B PICK1 NRGN GRIN2D GNAI3 AKAP5 GRIN1 GNAI1 DLG1 GRIN2A NCALD GNAI2 DLG2 CHRND DLG3 LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption MGAM SLC5A1 SLC2A5 SLC2A2 SI CLPS LCT PNLIP ALPI RSC1A1 PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF PIR PNLIPRP3 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLL1 DYNLL2 IFT172 KIFAP3 IFT52 IFT57 DYNC2H1 IFT140 WDR35 IFT88 KIF3A TTC21B WDR19 IFT122 KIF3B KIF3C DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 KIF17 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 TNPO1 CLUAP1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MTIF2 MRPS25 MTIF3 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MRPS17 MRPS15 MRPS16 MTFMT MRPS14 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME PON3 ABCB1 UGT1A3 SLCO1B1 SLCO1B3 PON1 ABCC2 CYP3A4 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA DDX21 ETF1 GSPT2 GSPT1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B UPF3A CNOT10 SMG1 SMG9 SMG7 SMG8 SMN2 SMG5 CNOT11 SMG6 UPF2 UPF1 PNRC2 NOP58 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 TYW5 GEMIN8 TYW3 TRMT5 DDX20 TYW2 TYW1 LCMT2 ADAR ADARB1 TNKS1BP1 RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPLP0 RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 LTV1 RRP1 GTF2H4 GTF2F2 FTSJ3 GTF2H5 EBNA1BP2 ISG20L2 CDK7 ERI1 ERCC3 LAS1L ERCC2 MNAT1 NOL12 RBM28 NOB1 RIOK2 RIOK1 TEX10 SENP3 GNL3 C1D NIP7 NOL9 EXOSC10 PES1 RIOK3 WDR18 WDR12 BYSL APOBEC1 BOP1 TSR1 APOBEC3C APOBEC2 MPHOSPH6 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B XRN2 HBS1L NT5C3B SKIC3 DCPS SKIC2 SLIRP MTPAP LRPPRC CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 NOP56 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PPP2R1A TP53RK STEEP1 TCERG1 EIF4A3 GPATCH1 RPS27 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 PRMT5 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 WDR77 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 PPP2CA ZRSR2 PRPF38A UPF3B NOP2 MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 TENT4A PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA LSM10 SNIP1 NCBP1 LSM11 MTREX NCBP2 TXNL4A PPP2R2A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 SEM1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 PHAX SNRNP27 PPIE TRUB2 SRSF3 MTERF3 SNRPE NSUN4 SRSF4 FASTKD2 PPIH MTERF4 PPIG SNRNP25 TFB1M SNRPF MRM1 SRSF5 MRM2 SNRNP200 MRM3 SRSF6 RCC1L SNRPC RPUSD4 SRSF7 NGRN SRSF8 RPUSD3 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 RPS4Y2 SNRNP48 RPS27L BUD13 RPS4Y1 TRMT10C PPIL3 PRORP PPIL4 RPS4X ELAC2 RPS15 FAM50A RPS14 TRNT1 HSD17B10 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 PAN2 PAN3 FASTKD5 POP5 TBRG4 POP7 CLNS1A OSGEPL1 SNUPN POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 DDX39B RPP38 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU EIF4E QNG1 EIF4B TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 GRSF1 NSUN6 DUS2 YWHAB QTRT1 HSPB1 GON7 ELAVL1 PSMD8 QTRT2 PSMD6 CTU2 ZFP36 CTU1 PSMD7 TSEN34 URM1 XPO1 PSMD2 LAGE3 KHSRP RPP14 PSMD3 TRDMT1 AKT1 RTRAF PSMD1 TRMT10A ADAT1 TNPO1 NUP214 TPRKB TRMT1 DIS3 PRKCD ADAT3 PRKCA TRIT1 ADAT2 YWHAZ PSMA5 XPOT PSMA6 TRMT6 PSMA3 FAM98B PSMA4 TRMT61A PSMA1 TRMT61B XRN1 RAN PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 CSNK1D EXOSC5 PSMB5 CSNK1E EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ZNF473 IGF2BP1 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 GAR1 NHP2 NOP10 DKC1 PELP1 ZC3H4 ZC3H3 EIF4A2 REXO2 IGF2BP3 EIF4A1 DDX49 TUT7 IGF2BP2 DDX47 TUT4 WDR3 DXO FCF1 ZCCHC7 NAT10 YTHDC1 THUMPD1 YTHDC2 PWP2 ZC3H18 WDR46 PNPT1 WDR43 RBM27 RRP9 RBM26 FBL TENT4B BUD23 SUPV3L1 UTP14A ZFC3H1 UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 PAIP1 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 RPLP1 DHX37 RPL34 RRP36 RPL10L UTP20 RPL8 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 UTP3 RPL18A PNO1 RPL36AL RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A WDR82 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 SKIC8 ZCCHC8 NCL TGS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP ACVRL1 BMPR2 AMHR2 GDF2 UBE2D1 SMAD9 SMAD5 GREM2 ZFYVE16 CER1 BMPR1B BMPR1A AMH NOG ACVR2B ACVR2A INHBA INHA CHRDL1 SKI SMAD1 SMAD4 SMURF2 SMAD7 SMURF1 SMAD6 TGFBR3 BMP2 UBE2D3 FSTL1 BMP10 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay ZFC3H1 PABPN1 SRRT TENT4A EXOSC7 EXOSC6 EXOSC5 EXOSC4 PAPOLG ZCCHC8 EXOSC9 NCBP1 MTREX NCBP2 C1D EXOSC8 EXOSC10 EXOSC3 EXOSC2 EXOSC1 RBM7 MPHOSPH6 ZC3H4 ZC3H3 WDR82 XRN2 DXO ZCCHC7 YTHDC1 YTHDC2 ZC3H18 RBM27 RBM26 TENT4B DIS3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis FTH1 FTL BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN AP3S1 TPD52 CLINT1 DNM2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 IGF2R DTNBP1 ARF1 GOLGB1 NAPA RAB5C TGOLN2 AP3B1 TXNDC5 OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SAE1 SUMO3 SUMO2 SUMO1 UBA2 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes HVCN1 KCNU1 CATSPERB CATSPER1 CATSPERD CATSPER3 CATSPERG CATSPER2 CATSPER4 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis CYP11B1 HSD3B2 HSD3B1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYP11B2 POMC SERPINA6 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP5 GP9 F9 F10 GGCX F8 GP1BA GP1BB F11 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex GPS2 NCOR2 NCOR1 TBL1XR1 TBL1X HDAC3 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes TLE1 TLE5 TLE3 TCF7L2 TCF7L1 CTBP2 HDAC1 CTBP1 LEF1 TLE4 TCF7 TLE2 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD OPLAH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNG13 GNB2 GNAQ GNB1 ADCY9 GNB4 PIK3R2 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB PECAM1 MLST8 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 PIK3CB CALCRL ADM TLN1 CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PIK3CA P2RY2 MMP14 GNG12 MAPKAP1 GNG11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MMGT1 ADD3 DMTN RHCG ADD2 ADD1 TUSC3 CTNS MAGT1 PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 RHAG AZGP1 ANKH MRS2 SLC66A1 NIPA1 NIPA2 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions IQGAP1 PIK3CB NCK2 PIK3R2 NCK1 PIK3R1 ACTN3 KIRREL3 ACTN2 KIRREL1 KIRREL2 ACTN1 MAGI2 FYN CD2AP SPTAN1 NPHS1 CASK WASL PIK3CA ACTN4 SPTBN1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX2 EHHADH ACBD5 AMACR ACOX3 SLC27A2 ACOT4 ACOXL NUDT7 CROT CRAT PECR HSD17B4 HACL1 ABCD1 DECR2 NUDT19 HAO2 ACBD4 ACAA1 PHYH ACOT8 SLC25A17 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling RELA MAP3K7 MAP2K6 IL1R1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 USP14 BTRC NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N NFKB1 CHUK IKBKB SQSTM1 MYD88 IRAK3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL1R2 PSMD13 NFKB2 TOLLIP PSMA7 PSMB6 PSMB7 PSMB4 MAP3K3 NKIRAS1 NKIRAS2 PSMB5 MAP3K8 IKBKG UBB IKBIP RIPK2 PSMB2 MAP2K4 PSMB3 IRAK4 UBC PSMB1 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism DMGDH CHDH SARDH ALDH7A1 BHMT SLC44A1 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) GP5 GP9 SERPING1 KLKB1 GP1BA F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression CXCL8 DCP2 HSPA5 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EIF2S2 EXOSC4 EIF2S1 EIF2S3 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP EIF2AK3 DIS3 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage IL18 CASP5 IL1B GSDMD CASP3 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis TPH2 DDC ASMT AANAT TPH1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs H2BC9 H2AZ2 POLR2A H4C9 POLR2B H2BC8 POLR2C H2BC5 POLR2D H2BC3 POLR2E RAN POLR2F H2BC1 POLR2G POLR2H POLR2I POLR2J H2AC20 POLR2K POLR2L IPO8 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B AGO1 H3C8 AGO2 H2AC8 TNRC6A H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling YWHAE NGFR NGF CASP2 BEX3 CASP3 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 SEPHS2 SECISBP2 EEFSEC RPS4Y2 SEPSECS RPS27L PSTK RPS4Y1 RPS4X RPS15 RPS14 RPS17 SARS1 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 PNPLA2 DGAT2 MGLL DGAT1 DGAT2L6 AWAT2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism PRSS1 TCN2 CD320 ABCC1 LDLRAP1 CTRB2 CUBN CBLIF MMAB CTRB1 AMN MMACHC MMADHC ABCD4 MTR MTRR LRP2 PRSS3 MMAA MMUT TCN1 LMBRD1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling CBL UBA52 FGF20 ANOS1 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET SOS1 ITGA3 STAT3 USP8 PIK3R1 NRAS PTPRJ RAP1B ITGA2 RAP1A STAM2 MET PTPN1 PTPN11 GGA3 SPINT1 HPN SPINT2 SRC HGFAC LRIG1 CRK LAMA5 SH3KBP1 LAMA2 LAMB3 LAMC3 CBL LAMB2 LAMA1 LAMA4 UBA52 LAMA3 LAMB1 STAM LAMC2 LAMC1 ARF6 RAB4A RAB4B DOCK7 HGS RANBP9 UBB RANBP10 RAPGEF1 UBC PTPN2 MUC20 RPS27A SH3GL3 EPS15 TNS4 SH3GL2 TNS3 SH3GL1 RAC1 HRAS GAB1 HGF PTK2 CRKL PIK3CA ITGB1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX CYP27A1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling GNG13 GNB2 GNAQ GNB1 PPP2R5D ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 MAPK1 GNGT2 GNAT3 PRKACG PRKACA PRKACB PLA2G4A PPP2CA PPP2CB GNA14 PPP1R1B PDE1B GNG3 PDE1A GNA15 CDK5 ITPR1 ITPR2 GNG2 CAMK2B ITPR3 GNG5 GNG4 CAMK2D GNG7 GNA11 GNG8 PDYN CAMK2A PDE4A PDE4D PDE4C GNAI3 GNAI1 GNAI2 OPRM1 CALM1 CAMK2G PRKCD PRKCA PLCB4 POMC PPP3CC PPP1CA PPP2R1B PPP2R1A PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX PPP3CA CAMKK1 PPP3CB CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 GNG10 NBEA PPP3R1 GNG12 GNG11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 FLRT1 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FLRT3 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FLRT2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis MBOAT7 MBOAT1 DDHD2 AGPAT2 MBOAT2 DDHD1 LPGAT1 PITPNB CPNE7 CPNE6 GPAM CPNE1 CPNE3 MFSD2A PISD PLA2G4A PLA1A PGS1 PTDSS2 PTDSS1 TMEM86B PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLA2G2A PLAAT5 PLAAT4 PNPLA8 LIPI LIPH ETNPPL PNPLA3 STARD7 PLB1 PLBD1 MIGA2 MIGA1 PLA2G3 PLA2G15 PHOSPHO1 PLA2G5 PLA2G10 PLA2G6 GPD1 PTPMT1 CHAT PLD4 PLD6 PLD3 CHKB CHKA STARD10 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 ACHE LPCAT1 PLD2 OSBPL10 ALPI GPD2 GNPAT PCTP LPIN1 LPIN2 MGLL PLA2G4F LPIN3 PLA2G4D PLA2G4E GPAT4 PLA2G4B PLA2G4C GPAT3 GPCPD1 CEPT1 AGPAT5 BCHE AGK PLA2G1B LPCAT4 AGPAT1 ETNK2 SELENOI LPCAT3 AGPAT3 ETNK1 AGPAT4 LPCAT2 LCLAT1 PLA2G2F PLA2G2D PLA2G2E PCYT2 PGP PLA2R1 CHPT1 GPD1L ABHD4 ABHD3 OSBPL8 CDS1 PITPNM1 PITPNM3 PNPLA2 OSBPL5 PITPNM2 CDIPT ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B AWAT2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 RXRB MYLIP REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors PHF20 AKT2 POU4F1 POU4F2 TP63 TP73 PPP1R13B TP53 PPP1R13L AKT1 TP53BP2 BANP AKT3 ZNF385A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling SOS1 PIK3R2 PIK3R1 KLRK1 NRAS PLCG1 BTK HLA-E GRAP2 LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 MYD88 TLR7 IRAK1 UBE2V1 TRAF6 IRF7 TLR9 UBE2N MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling RELA NGF SMPD2 IRAK1 ADAM17 NFKBIA ARHGDIA YWHAE TRAF6 PRDM4 BEX3 PRKCI TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ECT2 ITGB3BP ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 LINGO1 MAG OMG RTN4 HDAC2 CASP2 UBA52 UBB RIPK2 UBC RPS27A CASP3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling ATP5MC2 ATP5MC3 ATP5PB ATP5F1C ATP5MK ATP5F1D MT-ATP8 ATP5MJ ATP5F1E MT-ATP6 ATP5MC1 ATP5MG ATP5PO ATP5MF ATP5ME DMAC2L ATP5F1A ATP5F1B ATP5PF ATP5PD MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling PIK3CB SOS1 ANGPT4 SHC1 ANGPT2 ANGPT1 PIK3R2 PIK3R1 TEK DOK2 NRAS HRAS GRB7 PIK3CA PTPN11 GRB14 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER PREB STX5 LMAN2 FOLR1 CTSZ SEC24D CTSC SEC24C COL7A1 SAR1B MIA3 TMED10 SEC22B TMED2 SEC23A SERPINA1 AREG GRIA1 GOSR2 LMAN1 LMAN1L LMAN2L CD59 TGFA F5 F8 CNIH1 SEC24B CNIH2 CNIH3 MCFD2 SEC24A MIA2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A UPF1 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 NCBP1 RPS19 NCBP2 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants ERBIN SOS1 HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants KIT PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion UBC RPS27A RAB7A VPS33B CORO1A HGS RAB5A UBA52 UBB LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis AKR1B15 HSD17B14 HSD17B11 HSD17B1 HSD17B2 CYP19A1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC APPL1 DCC UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 CASP3 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 STAT5A STAT5B CBL CDKN1A PIK3R1 GRB2 NRAS UBA52 GOLGB1 MYO18A FLT3 ETV6 UBB PTPN11 UBC RPS27A BCL2L1 TRIP11 PIM1 HRAS ZMYM2 FLT3LG GAB2 PIK3CA SPTBN1 NOX4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 PTGR1 CYP4A22 CYP4B1 ALOX5AP MAPKAPK2 DPEP2 DPEP1 GGT1 ABCC1 ALOX15 CYP4F22 ALOX5 LTA4H LTC4S CYP4F3 CYP4F8 CYP4F2 CYP4A11 CYP4F11 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 RHOC CDKN1B PPP1R12A RHOA RHOB RAC1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 PPP1R12B DLG4 PPP1CB PRC1 CIT CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage IL18 IL1B CASP4 GSDMD CASP3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 GLTP CPTP CLN3 ESYT1 ARF1 ESYT3 ESYT2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC26A2 SLC22A5 GCKR SLC5A1 GCK SLC5A2 SLCO1B1 SLCO1B3 CP SLC6A5 SLC2A9 SLC67A1 SLC26A4 SLC26A3 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH AVPR1B SLC2A10 AVPR2 AVPR1A SLC24A4 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C SLC5A5 NUP42 NUP85 TPR NUP62 SLC35C1 NUP88 NUP43 RAE1 NDC1 SLC20A2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC24A1 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC17A5 SLC35A2 SLC35A3 SLC9A6 SLC33A1 AVP SLC9A9 SLC35A1 SLC29A3 SLC6A19 SLC4A1 SLC36A2 SLC27A4 SLC4A4 BSG SLC6A14 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC7A7 SLC5A7 SLC7A9 SLCO2A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 CSK HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 PTPRC HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 PAG1 HLA-DQB2 HLA-DQB1 LCK P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR NGF PRDM4 HDAC1 HDAC2 HDAC3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC5 HDAC1 HDAC3 HDAC8 HDAC9 HDAC6 HDAC7 MAMLD1 TBL1X RBPJ CREBBP MAML2 NCOR2 MAML1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 SNW1 HDAC11 HDAC4 HDAC2 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate TST ETHE1 SLC25A10 TSTD1 SQOR SUOX DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 APOA1 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 TLR4 HNRNPA1 STAT2 LY96 MAPKAP1 PDCD6IP FASN C4BPA C4BPB ATG14 HSP90AB1 CTNNB1 C4B_2 SDC4 SDC2 SDC3 RPTOR MLST8 GPC1 GPC3 UBE2I GPC2 GPC5 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H2AC25 NEK2 H2AC21 GTF2F1 GTF2F2 IFIH1 HSPA8 UBR4 NRBP1 PEX19 HNRNPA0 CD2BP2 HNRNPUL1 AUP1 PPIL6 ELAVL2 RICTOR H2AC1 CPSF7 SRRM1 VIM HNRNPC RIPK1 RBMX STING1 NFKBIA MAVS CLEC5A HSP90AA1 H2BC18 BECN1 DAXX H2AC19 H2BC26 H2AC14 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 CDC40 H2AC20 DHX9 HSPG2 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 SF3A1 SF3A2 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN WBP11 PRPF6 SNRPG SRSF2 PPIE NFKBIB SRSF3 F2 SNRPE SRSF4 SNRPF SRSF5 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNG13 GNB2 GNAQ GNB1 KCNJ11 ABCC8 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ACACB ADCY6 ADCY5 GNGT2 RAP1A PRKACG SLC2A1 SLC2A2 PRKACA PRKACB RAPGEF3 FFAR1 RAPGEF4 GNA14 GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 IQGAP1 GNAS GCGR GCG CHRM3 PPP2R1B PPP2R1A ACACA PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 CACNB2 PLCB3 PLCB1 PLCB2 ACSL4 ACSL3 ACLY CACNA1D FASN PPP2R5D STXBP1 INS ADRA2C SYT5 MLX ADRA2A PRKAA2 CACNB3 PRKAG2 PPP2CA STK11 PPP2CB CACNA1A CACNA1E STX1A TKT PRKAB2 KCNG2 AKAP5 GNAI1 GNAI2 AGPAT1 PRKCA CD36 SNAP25 KCNC2 CACNA1C PFKFB1 GLP1R ADIPOQ MLXIPL ADIPOR1 ADIPOR2 TALDO1 KCNB1 KCNS3 VAMP2 AHCYL1 MARCKS GNG10 GNG12 GNG11 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation PSMB3 PSMA5 PSMA6 PSMB1 PSMA3 PSMA4 PSMA1 PSMA2 PSME2 PSMB10 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB8 PSMB9 PSMB5 PSMB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC12 MUC17 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD TBXAS1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CBLL1 CTNNB1 RPS27A CDH1 CTNND1 UBA52 SRC UBB ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A4 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis SEL1L IHH VCP DERL2 ERLEC1 OS9 ADAM17 GPC5 P4HB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 DISP2 PSMC2 SCUBE2 NOTUM SYVN1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins ISCU RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants HRAS NF1 SPRED3 SPRED2 SPRED1 NRAS DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS NCAN CSPG4 CHSY1 BGN DCN BCAN VCAN CSPG5 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 PRSS3 CTRB2 CUBN TCN1 CBLIF CTRB1 AMN LMBRD1 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL HADHB HADHA PLA2G6 PLA2G4A LCLAT1 TAFAZZIN LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism ALDH4A1 PRODH PRODH2 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) VAMP2 SV2C SV2B SV2A VAMP1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism ADA2 SFTPB SFTA3 SFTPA1 ZDHHC2 SFTPA2 CTSH ADRA2C TTF1 ADRA2A DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 ADORA2B ABCA3 GATA6 ADORA2A CKAP4 SFTPD P2RY2 SLC34A2 SFTPC SLC34A1 CSF2RB CSF2RA ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide CA4 AQP1 HBA2 SLC4A1 CA1 RHAG CA2 HBB DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE ABCC6 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 FPR1 FPR3 APP SAA1 FPR2 HEBP1 ANXA1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 TGFB1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SMURF2 EP300 SMURF1 ADRM1 SRC MDM2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 RUNX3 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 CBFB IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 TRAV29DV5 IGLC3 TRBV7-9 TRBC1 IGLC1 IGLC2 IGKV3D-20 TRAV19 IGKV2-30 IGLV3-19 IGHV2-70 TRAV8-4 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 HLA-H HLA-B V2-11 HLA-C V3-4 HLA-F V3-3 V2-17 HLA-G HLA-E V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 CD19 V2-8 V1-20 TREM2 V1-9 V5-4 V1-7 V5-1 CDH1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD40LG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 C3 VCAM1 SIGLEC9 CXADR ITGB7 B2M HLA-A CD8B SIGLEC5 FCGR1A JAML CD99 ITGB2 COLEC12 ITGB1 CD33 ITGAL ITGA4 LILRA3 IFITM1 CD226 CD1D CD1C CD1B cd21 LAIR1 CD1A SLAMF7 LILRB2 SLAMF6 LILRB3 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD22 CD200 CD300A NCR1 NCR3 CD200R1 OSCAR HCST TYROBP LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 SELL KLRK1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 NCR2 SIGLEC1 SIGLEC8 KIR2DS2 SIGLEC7 SIGLEC6 PVR CD96 CD300LB CD8A TREM1 KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 CD300E KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 KLRD1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 CLEC2B FCGR2B CLEC2D NECTIN2 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRND CHRNA3 CHRNA4 CHRNG CHRNE PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UCK1 PUDP TK2 TK1 CDA DCK UPP2 UPP1 TYMP UCKL1 UCK2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCK ZAP70 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM12 ADAM19 SH3PXD2A TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 TICAM1 TLR3 RIPK3 CASP8 FADD SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin PRKCA HRAS SOS1 MMP3 HBEGF EGFR NRAS PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNQ1 CACNG4 KCNE5 AKAP9 CACNG6 CACNG7 CACNA1C CACNA2D2 CACNB2 CACNG8 CACNB1 KCNE1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 SPTAN1 POMT2 FYB1 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 ACTN3 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 CASK FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A IQGAP1 JUP RB1 RBBP4 WASL RBBP7 H2AX PIK3CB KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L NCK2 H2BC21 NCK1 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 SIRPG SKAP2 PIK3CA BANP SPTBN1 ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 H2AC20 KIRREL3 KIRREL1 KDM1A KIRREL2 MAPK1 MAGI2 CD2AP NPHS1 MAPK3 PTPN11 CD47 HDAC2 SRC ACTN2 SUZ12 SIRPA ARID1A TYROBP PTK2B PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 SIRPB1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 PTPN6 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 FYN SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 PTK2 CTSL NECTIN1 ACTN4 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 GUCY1B2 KCNMB4 GUCY1B1 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE5A NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis IMPDH1 ADSL IMPDH2 PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS CAD DHODH UMPS ATIC SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants FLT3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand ACD PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 RPA3 WRN DNA2 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin STAT5A STAT5B JAK2 LEP STAT3 SOCS3 IRS1 PTPN11 IRS2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors ZFP36L2 PAIP1 PABPC1 CNOT4 CNOT6 CNOT7 EIF4E EIF4B DICER1 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 BTG4 CNOT6L CNOT11 EIF4A2 EIF4A1 EIF4G1 PABPN1L EIF4A3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 STAM2 STON1 GPS1 STON2 COPS4 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 SGIP1 AP2S1 AGTR1 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 APOB SNAP91 M6PR SYT2 ARRB1 ARRB2 SCARB2 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 TGOLN2 CHRM2 HGS CD4 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 SLC18A3 DAB2 EPS15L1 EPN1 SYT9 GRK3 PICALM VAMP8 IL7R TFRC CFTR SYT1 IGF2R UBA52 STAM UBB UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG BTC EPGN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9 CYP2C8 CYP2J2 CYP1A2 CYP1A1 CYP1B1 EPHX2 CYP2C19 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GCGR ADCY7 ADCY6 GCG ADCY5 PRKACG PRKACA PRKACB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling APOA1 APOA4 APOB APOA5 GPIHBP1 APOE APOC2 APOC3 LPL APOA2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 CDH11 AGO1 AGO2 TNRC6A TNRC6B CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia CITED2 CA9 ARNT HIF1AN UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 VEGFA PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC HIGD1A PSMB1 RPS27A EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EPO DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) FMOD PRELP B4GALT1 OMD KERA ACAN OGN LUM SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants FLT3 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CSNK2A1 CLOCK DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l ALG9 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 GYG2 GYS2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system JUN TRIM6 IFNA2 TRIM5 TRIM2 IFNA8 TRIM3 CSH1 XAF1 ARIH1 RELA IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 TRIM45 NPM1 TRIM35 TRIM38 TRIM31 OAS2 TRIM34 IFITM3 IFNA10 IFITM2 IFIT5 IFNA21 IFI35 IFI30 IFIT3 IFNB1 EIF2AK2 IFIT2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR IRF8 IRAK1 IRF6 IRF9 SAMHD1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A KPNB1 IL1B KRAS PELI1 MMP1 FNTA MMP2 DNAJC3 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N ADAR IRF1 IRF2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 HSPA1L HSPA2 MAPK8 ATF6 BCL2L11 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 FCER2 CANX UBE2I PTGS2 SUMO1 ALOX5 UBE2D2 UBE2D3 ELOB ELOC RBX1 TRIM25 SDC1 HIF1A GH1 SNAP25 GATA3 LYN INPP5D TNFRSF12A TNFSF12 TNFRSF13C ARF1 TNFRSF11A CD40LG RALA RPLP0 LTBR IL1RN PITPNA LTB BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IFIH1 IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ACTB ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA KPNA2 TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 KPNA7 FKBP5 KPNA4 KPNA5 CSF1R GBP1 KPNA3 MAP3K7 FPR1 SPHK1 MAP2K6 TCP1 MT2A FANCC BCL6 SMAD3 SMAD7 ADAM17 NFKBIA MAVS TAB1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TRAF2 NUP43 RAE1 KPNA1 ILF2 NDC1 TRAF3 RANBP2 TEC TRAF6 SEC13 BIRC2 NUP155 NUP133 NUP210 BIRC3 NUP153 NUP93 USP14 BECN1 NUP50 NUP35 NUP54 NUP37 NOD1 ITGAM ITGB2 ACTG1 FLT3 NOD2 IRS1 USP18 PPP2R1B IRS2 EIF4E3 PPP2R1A PIK3CB IFIT1 PPM1B PML EIF4E2 FLNB FGF2 TNFRSF1B MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 SOX2 TNIP2 GRB10 HRAS PTPN13 INPPL1 FLT3LG TWIST1 IRF5 EIF4A3 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5A SHC1 PPP2R5D PIK3R2 PIK3R1 BST2 NRAS RHOU ALOX15 PTPRJ MAPK1 BIRC5 DHX9 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CDC42 LIFR CD44 PPP2CA PPP2CB CAMK2B HNRNPF CAMK2D SRC CAMK2A CASP1 OPRM1 EIF2AK3 CAMK2G CENPS IFNG UBE2E1 MCL1 CD86 PTK2B UBE2D1 CD80 VEGFA CDK1 IL22 POMC CXCL1 NFKB2 CSK JAK2 HNRNPA2B1 ILF3 IL2RG MMP9 FBXW11 THOC5 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B HSPA5 CCL3L3 CCR5 RAF1 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 YBX1 PRKRA TARBP2 IFNAR1 P4HB PRTN3 TIMP1 POU2F1 PLCG2 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FLNA FN1 BRWD1 BLNK GRAP2 HLA-DQA2 BTRC S1PR1 HLA-DQA1 JAK3 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCN2 STAT2 MMP3 UBE2L6 HERC5 IL23R IL13RA2 IL13RA1 HLA-H IL4R IL23A CDKN1A FSCN1 HLA-B NDN HLA-C LIF NANOG HLA-F HLA-G IGHE HLA-E OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 EIF2S2 ATF2 STX3 EIF2S1 IL10RB EIF2S3 CLCF1 EGR1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C EIF4E IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 GBP5 IL11 PIM1 IL19 IL16 DUS2 PGGT1B IL17RE GBP2 OSMR GBP4 PSMD8 IL17RB GBP3 PSMD6 HMOX1 IL31 SLA IL17C SLA2 PSMD7 IL11RA SOCS2 IL7 PSMD2 SOCS6 IL7R SH2B3 IFNL2 PSMD3 IFNL1 AKT1 IRF7 IFNL3 PSMD1 PSMB8 NUP214 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A FAAP100 UBE2V1 FAAP24 HSPA8 VAMP2 CUL5 ICAM1 TNFSF13 FAAP20 FANCM ADRM1 UBA7 FANCL MAPK14 FANCA MAPK11 PSMC5 FANCB PSMC6 FANCE PSMC3 FANCG PSMC4 FANCF PSMC1 PSMC2 ABL2 HSPA1A EIF4G1 PAK2 RAG2 RAG1 IL32 CASP3 FURIN UBA3 IL34 IL1RL1 GAB3 IL33 TGFB1 UBE2M FCGR1BP LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 B2M RELB IRF3 MAP3K14 HLA-A RNF7 TRIM21 GBP6 RORC RORA TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A FCGR1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 CENPX TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 HSP90AA1 NEDD4 TNFSF4 LTA CBL CD27 TNFSF9 PLCG1 TNFRSF25 TNFSF8 CDKN1B PDE12 OASL OAS1 FNTB OAS3 RNASEL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 EIF4A2 EIF4A1 MAP2K1 HSP90B1 H3C15 NCAM1 STAT3 NFKB1 ITGAX PIN1 FASLG TNFRSF18 PRL IFITM1 PIAS1 SNCA IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 ABCE1 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 AKT3 TRIM8 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CUBN CBLIF AMN HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) ABL1 RAD52 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 RAD50 RAD51 RPA3 RAD17 RAD1 ATM ERCC4 DNA2 ERCC1 RAD9B RHNO1 ATR RAD9A TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins PRKCSH UBA52 GANAB ST6GALNAC3 ST6GALNAC4 MGAT1 GALNT1 MOGS UBB UBC ST3GAL4 CANX RPS27A ST3GAL1 ST3GAL2 UBE2I ST3GAL3 SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 PARP14 PARP8 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle TFRC KIF14 KIDINS220 DSG1 NUDC VANGL1 ARHGAP1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 PLXND1 PRAG1 TXNL1 ALDH3A2 PKP4 ANKRD26 LEMD3 DEPDC1B RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 BLTP3B TNFAIP1 RND2 PTPN13 NISCH GOLGA3 KTN1 CKAP4 FNBP1 KCTD13 FRS2 SCRIB VANGL2 LRRC1 CAV1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 NECTIN2 CADM3 CADM1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation PLK3 PIN1 CDK2 PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 PRKAG2 PRKAG3 NOC2L STK11 TAF7L CDK5 PRKAB2 TP53INP1 MDM2 PRKAB1 MDM4 TAF4B DYRK2 TBP UBA52 TAF9 TAF1L AURKA TAF15 HIPK1 TAF12 BLM TAF13 MRE11 MAPKAPK5 HIPK2 BRCA1 TAF11 WRN BRIP1 TAF8 KAT5 TAF7 EXO1 CHEK1 TAF6 RBBP8 TAF5 NBN UBB TAF4 TOPBP1 TAF3 SUPT16H ATRIP TAF2 BARD1 TAF1 RFC5 UBC RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TAF10 TP53RK TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CHEK2 CSNK2A2 TAF9B RAD50 CSNK2B RPA3 RAD17 CCNA2 TP53 RAD1 CCNA1 ATM DNA2 NUAK1 RAD9B RHNO1 ATR RAD9A TPX2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 ATP6V0D1 TFRC HFE ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 TF TCIRG1 STEAP3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 MCOLN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols RXRA CYP51A1 NCOA2 CYP19A1 POMC ARNT2 CYP7B1 CYP11A1 NCOA1 CYP7A1 CYP1B1 CYP27A1 CYP39A1 CYP11B2 CYP11B1 ARNT CYP21A2 AHRR FDXR CYP8B1 NR1H4 CYP46A1 CYP4V2 FDX1 FDX2 AHR RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 TAX1BP3 RHPN2 RTKN RHOC LIN7B ROPN1 RHOA RHOB DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription KLF4 SP1 TFAP2A ZEB2 FOXP2 FOXJ2 STRAP KLF9 ARID1A FOXA2 RB1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 IL25 TAB1 IL17RE IL17RB IL17C IL17RC IL17RA IL17F IL17A MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts RXRA OSBP NCOA2 AMACR SLC27A2 SLC27A5 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 NCOA1 CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 OSBPL1A ABCB11 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 ESPL1 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A PTTG1 KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMD8 CENPI PSMD6 TAOK1 CENPK PSMD7 CENPL XPO1 CENPM PSMD2 CENPN B9D2 PSMD3 CENPO CENPP PSMD1 CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PSMA5 PLK1 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CLIP1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling ITGA3 LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 SRC LAMB1 LAMC2 LAMC1 ITGA2 MET HGF PTK2 ITGB1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation SOX17 TBX6 POU3F1 YAP1 POU5F1 PAX6 MAMLD1 FOXC2 CXCR4 FOXC1 IHH PAX2 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD4 GSC SMAD3 MIXL1 PAX3 ZNF521 FOXA2 FGFR1 MAML2 DLX5 MAML1 FGF2 FGF4 MYB EP300 SOX2 GATA6 TBXT EOMES MAML3 NOTCH1 BMP4 TCF7L2 TCF7L1 NANOG LEF1 TCF7 ZIC1 CTNNB1 RBPJ TFAP2A TFAP2B CDH1 SNW1 TFAP2C EPHA4 TEAD2 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TBPL2 GATA4 MSX1 PSMA5 OSR1 PSMA6 PSMA3 ZIC2 PSMA4 PSMA1 TRIM33 PSMA2 PAX8 PAX7 PSMD12 PSMD11 NOG PSMD14 NOTO FOXH1 PSMD13 FOXF1 WNT3A PSMA7 PSMB6 SHH ZEB2 PSMB7 SNAI1 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP PSMB1 KAT2B KAT2A LFNG ADRM1 LHX1 PSMC5 PSMC6 SEM1 DLL1 PSMC3 PSMC4 PSMC1 FOXA1 PSMC2 FGF8 SOX1 GBX2 OTX2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation CLTC CLTA AP2A1 AP2A2 KIF5C AP2M1 KIFAP3 KLC1 KLC4 KLC3 KLC2 IFI30 SAR1B KIF3A KIF3B AP2S1 AP1G1 AP1S2 KIF3C SEC23A AP1S1 KIF5B AP1S3 KIF5A AP1M2 KIF4B AP1M1 AP2B1 HLA-DOA AP1B1 KIF4A HLA-DOB LAG3 KIF11 CTSO CTSF CTSE HLA-DMA HLA-DMB KIF15 RILP CD74 SEC24B SEC24A KIF22 SEC13 HLA-DQA2 SEC24D HLA-DQA1 HLA-DPA1 HLA-DRB5 SEC24C HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 DYNC1LI1 CAPZB DYNC1LI2 KIF26A CTSD KIF23 KIF20A KIF18A DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A ACTR1B CTSH CTSC KIF2C KIF2B CAPZA3 DNM1 CAPZA2 DNM2 DYNC1I2 LGMN ACTR10 SEC31A CANX DYNC1I1 DYNC1H1 CTSS CENPE DNM3 SPTBN2 ACTR1A ARF1 OSBPL1A RAB7A SH3GL2 DCTN2 CAPZA1 DCTN3 CTSA RACGAP1 CTSB CTSV CTSL CTSK ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A8 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 PTEN AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol PLCB4 INPP5D PLCG1 PLD4 OCRL INPP5B SYNJ1 PLCZ1 INPP5J PLCE1 ITPK1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC25A5 SLC28A3 SLC25A4 SLC25A6 ARL2 ARL2BP SLC29A4 SLC28A2 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation DOHH EIF5A DHPS EIF5A2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 ACADS HADH CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A COPS3 COPS6 COPS5 COPS8 CHMP3 CHMP6 CHMP7 PLA2G6 DCTN6 DCTN5 DCTN1 GJC1 DCTN4 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 MAN2A1 GJA9 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CHM TMED2 CD59 DNM3 CD55 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 COG8 COG7 COG6 COG5 COG4 COG3 RAB27B COG2 COG1 RINT1 RAB30 RAB36 TF KIF16B SAR1B KDELR2 KIF20B COPB2 COPA TMED10 ARL1 AP2S1 KIF3B AGTR1 MAN2A2 VTI1A LDLR SERPINA1 KIF3C RAB6B RAB39A KIF18B KIF4B AP2B1 ALPP KIF4A COPE KIF12 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 MAN1A2 F5 KIF13B F8 TMED3 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 STX4 KIF6 BET1L KIF27 COPZ1 SH3KBP1 SLC2A8 RAB33B KIF9 KIFC2 KIFC1 CD3G NAA35 CD3D NAA38 VAMP4 PAFAH1B3 ARF5 NAPA NAPB NBAS CHRM2 TMF1 STX16 STX18 GOSR1 GOLGA2 NAPG STX10 CYTH3 ARFRP1 CYTH2 CYTH4 CUX1 VPS51 CD4 VPS53 VPS52 MAN1C1 BNIP1 STX6 VPS54 CYTH1 RIC1 MYO1C GALNT2 ARCN1 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 SNX2 FNBP1L SNX9 SNX5 TBC1D8B PUM1 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 KIF20A TMEM115 CNIH2 CNIH3 MCFD2 MIA2 PPP6R1 TRAPPC6A FTH1 TRAPPC6B SEC22A SEC22C FTL STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF PLIN3 GGA2 GGA1 GGA3 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 TGFA EREG BTC EPGN AKT3 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria AUH DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM MMAA MMUT SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAH YWHAZ SFN SP1 SMAD4 SMAD3 EP300 UBE2I YWHAB PSMC6 YWHAE PDPK1 YWHAQ CAV1 YWHAG FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation FGFBP3 FGFBP1 FGFBP2 FGF1 FGF10 FGF2 FGF3 FGF22 FGF7 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 FRS3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 PIK3C2A MTMR9 MTMR4 MTM1 PIK3R4 FIG4 MTMR7 PIKFYVE PIK3C3 VAC14 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium UNC119B ARL3 CYS1 NPHP3 RP2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway TRAF2 TNFSF10 TNFRSF10B UNC5A TNFRSF10A DAPK1 UNC5B DAPK2 DAPK3 FADD CD14 MAGED1 APPL1 FAS FASLG TLR4 RIPK1 TICAM2 DCC TICAM1 LY96 TRADD CASP8 CASP9 CASP3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine MAOA TOMT SLC6A3 COMT REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling XIAP RACK1 STUB1 TRAF1 UBE2L3 TRAF2 UBE2D1 ULK1 MAPKAPK2 FADD USP4 UBA52 BIRC2 USP2 BIRC3 MIB2 CYLD SPPL2B SPPL2A CLIP3 RBCK1 OTUD7B CHUK IKBKG UBB IKBKB RIPK1 UBC RPS27A USP21 SHARPIN TNF TBK1 OTULIN OPTN TAX1BP1 UBE2D2 UBE2D3 TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA AREG EGF EGFR EREG BTC EPGN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin FST FSTL3 INHBB INHBA SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins RANGAP1 UBE2I SUMO1 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOA1 APOE APOC2 APOC3 LIPG ALB CETP ABCG1 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB SESN2 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SEC13 SZT2 SAMTOR SEH1L NPRL2 NPRL3 TCIRG1 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 ATP6V1E1 FNIP2 KICS2 ATP6V1E2 CASTOR1 CASTOR2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 HRAS FGF18 SOS1 FGF1 FGF2 FGF23 FGF4 FGF9 NRAS FGF20 FGF16 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency TCN2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase CEP41 TUBGCP4 CEP43 TUBA1A PRKACA SMC4 SMC2 YWHAE TUBB4B TUBB4A NUP107 EML4 CDCA5 NUP160 NCAPG YWHAG NCAPH NUP85 NUP43 HSP90AA1 NCAPD2 RANBP2 SEC13 NUP133 NUMA1 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 CPAP KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PRKAR2B PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CCP110 CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 TUBG1 HAUS2 HAUS1 MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 CSNK2A1 DCTN3 HAUS8 HAUS7 CSNK2A2 CEP70 CEP72 CEP192 TUBA4A PCNT CSNK2B CEP76 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 NEK7 MZT1 NEDD1 ALMS1 TUBGCP5 CLIP1 TUBGCP6 TUBGCP3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDKN1A POT1 TERF2IP H2AC20 HMGA2 H1-1 H1-0 H1-3 CDK2 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A RB1 CDKN1B HMGA1 MRE11 KAT5 CCNE2 CCNE1 H2AX NBN H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 CCNA2 TP53 CCNA1 H2BC11 ATM HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation GUSB CD44 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HYAL2 HEXB HEXA CHP1 SPAM1 HYAL1 HYAL3 HYAL4 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion F8 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) GGPS1 RXRA SCD CYP51A1 FASN LSS SREBF2 SQLE MTF1 DHCR7 ACACB GPAM NFYA NFYB NFYC TBL1X NCOA1 SAR1B SEC23A TBL1XR1 MBTPS1 SCAP MBTPS2 SEC24B SEC24A NCOA2 NCOA6 RAN INSIG2 SMARCD3 INSIG1 SEC24D MVD SEC24C CARM1 KPNB1 HELZ2 CREBBP CHD9 SP1 ACACA MED1 TGS1 IDI1 ELOVL6 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses C4A CLEC5A C4BPA C4BPB CDC73 EXOC1 HSP90AA1 SKIC8 DDX3X HSP90AB1 CTR9 CLU RTF1 VTN APOA1 LEO1 PAF1 IFIH1 C4B_2 CGAS RBM10 STAT2 STING1 MAVS UBR4 C1QA C1S MBL2 TRIM25 IKBKE PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 PAX4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI TRPC7 TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport TTPA RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H HDAC1 POLR2K POLR2L MTA2 GTF2H1 ERCC6 GTF2H2 GTF2H3 RBBP4 MTA1 GTF2H4 MBD3 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 RRN3 ERCC2 MNAT1 EHMT2 GATAD2B GATAD2A CHD3 KAT2B KAT2A HDAC2 UBTF POLR1A POLR1B CHD4 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism GNG13 CGA GNB1 TCF7L2 GNB3 KIF5C INS CTSZ SLC30A8 PCSK1 GNAT3 GPR119 SLC30A5 PAX6 CPB2 ISL1 GIP CTSG FSHB DPP4 CTNNB1 INHBB IGF1 SPCS3 INHBA SPCS2 SPCS1 INHA FFAR1 INHBC SEC11A INHBE SEC11C ACHE LHB ACE2 STX1A KIF5B KIF5A P4HB BCHE PCSK2 ERO1B CGB8 CPA3 MME CDX2 ENPEP AGT LEP EXOC8 CPB1 FFAR4 EXOC7 CLTRN ACE UCN CES1 CPE GATA4 MBOAT4 REN PLA2G7 CRHR2 GH1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GRP TSHB CMA1 GCG POMC ATP6AP2 KLF4 MYO5A RAB27A VAMP2 MYRIP CTSD ANPEP GZMH PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism PAH ASRGL1 KYAT1 QDPR IL4I1 PCBD1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription RUNX3 SMAD4 SMAD3 TP53 CDKN1A ZFHX3 TGFB1 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 CLTC RPS6KA1 CLTA AP2A1 AP2A2 AP2M1 RDX MAPK1 NUMB DNM1 DNM2 MSN AP2S1 SH3GL2 RPS6KA4 KIF4B AP2B1 KIF4A SHTN1 DNM3 RPS6KA6 EZR RPS6KA3 RPS6KA5 L1CAM DPYSL2 RPS6KA2 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins HERC2 XRCC4 PARP1 CDKN2A RAD52 MDC1 SP100 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 PIAS4 NSMCE3 NSMCE2 NUP88 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 CETN2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 BLM BRCA1 NUP37 WRN PML RPA1 SMC1A XPC SMC3 STAG1 STAG2 RAD21 TDG SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions SLCO4A1 SLCO2B1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A1 SLC25A10 SLC13A2 SLC22A12 SLC13A3 SLCO1C1 SLC5A12 SLC16A7 SLCO1A2 SLC16A8 EMB SLC13A5 SLC16A3 SLC17A5 SLC16A1 AVP SLC22A7 SLC22A6 SLC22A8 SLC10A6 SLC5A8 SLCO4C1 BSG SLC44A5 SLC44A3 SLC22A11 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLCO2A1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 CRY2 CRY1 ADRM1 FBXL21P PSMC5 PSMC6 PER2 SEM1 PSMC3 PER1 PSMC4 PER3 PSMC1 PSMC2 SKP1 CUL1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland PRL FGF10 TGFA AREG EGF FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 SGF29 NCOA6 KANSL1 PHF20L1 KANSL2 SETD1B KANSL3 SETD1A RBBP5 KMT2D PHF20 BOD1L1 ASH2L MBIP TASP1 KMT2C DR1 KMT2B BOD1 KAT2B KAT2A YEATS2 AKAP8L MEN1 TADA3 PAGR1 KAT8 OGT HCFC2 WDR82 PAXIP1 KDM6A DPY30 KAT14 MCRS1 WDR5 KMT2A PSIP1 ZZZ3 HCFC1 TADA2A DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 GALM CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane F8 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis PCSK1 CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE POMC RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants HRAS NRAS KRAS MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development RPS6KA1 EDNRB ASAH1 DICER1 TRPM1 PAX3 YWHAE SNAI2 TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 PXN SMARCD1 SMARCD2 SMARCD3 RARS1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 SMARCE1 MC4R DARS1 EEF1E1 LIG1 MC3R KARS1 GMPR IARS1 EP300 MC5R SOX2 AKT2 ATP6V1E1 SOX9 ATP6V1G1 ATP6V0B ATP6V0E1 KIT DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H ZIC1 FOXD3 MAPK1 TBX2 HINT1 TFE3 CCND1 MITF ITGA2 SIN3A TFEC ALX3 CDK2 TBX3 CTNNB1 MET ATP6V1C1 GPR143 MAPK3 EPRS1 TNRC6C MOV10 ID1 TFAP2A AGO3 STT3B AGO4 CDH1 UBE2I AGO1 AGO2 DPF1 SUMO1 TNRC6A TNRC6B DPF2 YWHAB DPF3 XPO1 SS18L1 ARID1A GSK3B ARID1B YWHAZ PPARGC1A PLK1 SS18 SMARCB1 CCNB1 POMC WNT3A SOX10 SMARCC1 BRCA1 SMARCC2 MARK3 ACTB ACTL6A CREBBP GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TFEB TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 AKT3 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK2 PANK3 PANK1 DCAKD DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex FRAT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 TCF7L1 HDAC1 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 PPP2CA PPP2CB PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 TLE5 APC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CTBP2 CTBP1 PSMB5 PPP2R1B UBB PPP2R1A PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TLE3 SKP1 CUL1 FRAT1 PPP2R5E MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling CRK ARF6 RAB4A RAB4B MET GAB1 GGA3 HGF CRKL IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA PPIA PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation SMAD2 SMAD4 GSC SMAD3 MIXL1 TRIM33 BMP4 POU5F1 SOX2 TBXT NANOG LEF1 TCF7 EOMES FOXH1 CTNNB1 TBPL2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot PLAT SERPINE1 SERPINB8 SERPINB6 S100A10 PLAU PLAUR SERPINE2 SERPINF2 SERPINB2 PLG ANXA2 HRG PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi ST3GAL4 TMED2 SEL1L RFNG MFNG B4GALT1 FURIN LFNG ST3GAL6 ST3GAL3 ATP2A3 RAB6A ATP2A2 ATP2A1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo YAP1 TJP2 WWC1 STK4 SAV1 WWTR1 STK3 MOB1B YWHAB LATS1 MOB1A LATS2 DVL2 AMOTL2 AMOTL1 YWHAE TJP1 NPHP4 CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA AREG EGF PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK2 CDK4 CCNE1 CDKN1B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) IDH3B CS ISCA2 IDH3A MDH2 ISCA1 ACO2 ACAT1 LYRM4 SUCLG2 KGD4 SUCLG1 CSKMT SDHC TRAP1 SDHD SDHA SDHB OGDH FXN NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH IDH2 SIRT3 DLST IDH3G DLD INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling STAT5A STAT5B UBE2D1 LYN STAT3 UBA52 JAK2 JAK1 STAT1 SOCS1 UBB CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins AQP1 GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 RAB11A PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 AVP GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A RAB11FIP2 MYO5B GNG10 AQP4 AQP2 GNG12 AQP3 GNG11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling NTRK1 CLTC AP2S1 CLTA AP2A1 AP2A2 SH3GL2 NGF AP2B1 AP2M1 DNAL4 DNM3 DNM1 DNM2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation MMP15 COL18A1 COL17A1 MMP19 COL15A1 COL16A1 TMPRSS6 COL13A1 COL14A1 FURIN COL12A1 COL19A1 ELANE COL26A1 COL25A1 COL23A1 ADAM10 ADAM9 PRSS2 MMP8 MMP9 COL9A1 MMP1 COL9A3 MMP2 COL9A2 ADAM17 PHYKPL CTSD MMP3 CTSB MMP20 CTSL MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation IKBKB TASL CHUK IRF5 SLC15A4 IKBKG TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling GNG13 ITGA5 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 SRC GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNAI3 GNAI1 GNAI2 GNG10 ITGB1 GNG12 GPER1 GNG11 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation TRAF2 RELA NFKB1 TRAF6 NFKB2 CHUK IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG IKBKB NFKBIA AGER MAVS RNF135 S100A12 MAP3K1 RIGI APP S100B SAA1 HMGB1 NFKBIB TRIM25 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE NPL NEU2 NEU3 NEU4 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA ST6GALNAC1 CMAS SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 NANP ST8SIA3 NANS GLB1 ST6GAL1 ST6GAL2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL PGM1 GYG1 PYGM PHKG1 PHKG2 GYG2 AKR1E2 AGL PHKA1 PHKB PHKA2 GAA CALM1 PYGB METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins ACE2 CMA1 CTSZ CTSD CPB2 CTSG CPA3 MME ANPEP ENPEP AGT CPB1 GZMH ATP6AP2 ACE CES1 REN REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 VCP TMPRSS2 CTSL HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation CREBBP RPTOR MLST8 HSP90AA1 HSPA8 EP300 CAMK2B CAMK2D HSPB8 HSP90AB1 CAMK2A MTOR DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A CRYAB AKT1S1 FKBP4 HSPA1B CAMK2G INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling STAT5A STAT5B STAT3 PIK3R2 PIK3R1 BRWD1 JAK3 JAK1 CISH TSLP IL2RG SOCS1 IRS1 IRS2 CRLF2 H3C8 SMARCA4 SOCS2 IL7 IL7R RAG2 RAG1 HGF PIK3R3 H3C15 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 FURIN HSPA8 CSNK2A1 HSP90AB1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RXRA CYCS HDAC3 NR1D1 TBL1X NCOA1 ESRRA ATF2 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 TWNK SSBP1 HCFC1 CALM1 PPARGC1A NCOA2 PPARGC1B NCOA6 SMARCD3 NRF1 GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HELZ2 CREBBP CHD9 ALAS1 MTERF1 GABPA MED1 SIRT5 TGS1 PPRC1 MEF2D PERM1 CAMK4 IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 PPARA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK STAT3 PIK3R2 PIK3R1 HDAC1 PLCG1 HDAC3 JAK3 SIN3A ALKAL2 ALKAL1 PRDM1 CD274 IL2RG PTPRZ1 IRS1 DNMT1 PIK3CB PTN MYCN MDK EP300 MYC PTPN6 HDAC2 ALK FRS2 HIF1A PIK3CA NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs NEIL3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MT-ND4L GFM1 GFM2 MRRF MT-CYB MTFMT MTRF1 TSFM MTRF1L MTIF2 MTIF3 MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation FCN3 FCN1 COLEC10 MBL2 MASP1 COLEC11 FCN2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism PAH ASRGL1 KYAT1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PCBD1 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia IVD TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host HBA2 HBB REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels ATP2A3 ATP2A2 ATP2A1 ATP2B4 SLC8A1 ATP2B3 SLC8A2 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors PARK7 PPARGC1A PIAS4 NCOA2 DDX5 NPM1 TRIM28 SIN3A NRIP1 HIPK2 DAXX ZNF131 UHRF2 NCOA1 DDX17 CASP8AP2 CTBP1 MBD1 SAFB TOPORS CREBBP MRTFA NCOR2 BMI1 PIAS3 ING2 SUMO3 SUMO2 EP300 RING1 UBE2I PIAS1 SUMO1 RNF2 CBX8 PHC2 PHC1 CBX4 PCGF2 CBX2 PHC3 ZNF350 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system UBC RPS27A TLR2 B2M UBA52 MRC1 UBB ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria E2F1 PMAIP1 TP53 TFDP1 TFDP2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B2 SLC26A2 SLC26A11 SLC26A1 PAPSS2 PAPSS1 SLC35B3 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2E1 CYP2F1 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2S1 CYP2D6 CYP2A7 CYP2A6 CYP2C19 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling TIAM1 LYN ARPC1B ARPC1A KALRN RHOA ROCK1 ROCK2 ARPC4 CFL1 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ARHGEF28 ACTG1 SDC2 ACTB CDC42 ITSN1 RASA1 YES1 PAK1 LIMK2 RAC1 HRAS LIMK1 FYN GRIN2B GRIN1 PTK2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PCNA AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA ELL CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XPA COPS7B COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 PPIE COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 ERCC5 COPS8 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GRIK5 GRIK3 GNG3 GRIK4 GRIK1 GRIK2 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD PLCB3 PLCB1 GNG10 DLG3 PLCB2 DLG4 CALM1 GNG12 GNG11 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LRP1 RETSAT APOA2 APOM APOA1 BCO2 APOA4 BCO1 HSPG2 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 RUNX3 ITGAL CBFB SPP1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS CYP19A1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis CAD DHODH UMPS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence CDKN2D CDKN2C CDKN2B UBA52 CDKN2A RB1 MAPK1 E2F1 E2F2 E2F3 CDK6 TFDP1 MAPK3 TFDP2 ETS1 CDK4 ETS2 UBB UBC SP1 TNRC6C ERF RPS27A MOV10 ID1 AGO3 AGO4 AGO1 MDM2 TNRC6A MDM4 TNRC6B TP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin MAOA ALDH2 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB14 RHOQ KIFAP3 RALGAPA2 RALGAPB RAB13 PRKAA2 KIF3A PRKAG1 PRKAG2 LNPEP PRKAG3 KIF3B PRKAB2 PRKAB1 YWHAB YWHAE C2CD5 EXOC8 EXOC7 AKT1 YWHAQ CALM1 YWHAG ASPSCR1 YWHAH EXOC4 YWHAZ EXOC3 SFN EXOC6 STX4 TBC1D1 EXOC5 SNAP23 TBC1D4 EXOC2 EXOC1 RALA RAB11A RAB4A MYO1C MYO5A VAMP2 AKT2 SLC2A4 RAB8A RAB10 RAC1 MYH9 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly GJB6 GJB5 GJB7 GJC1 GJC2 GJA3 GJA1 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJB2 GJD4 GJB1 GJD3 GJB4 GJB3 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF22 TGFBR3 GIPC1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling CXCL8 CD86 CD80 IL10RA PTAFR CXCL2 STAT3 LIF IL1RN CXCL1 FPR1 CCL3L3 IL1R2 CCR5 CCL5 IL12B IL12A CCL4 IL18 CCL3 JAK1 IL1A CCL2 IL1B CCL19 IL10 CCR2 IL10RB CSF2 CCR1 IL1R1 CSF3 CCL22 TYK2 CCL20 TNFRSF1B FCER2 CXCL10 TNF ICAM1 PTGS2 IL6 TIMP1 TNFRSF1A CSF1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 GP9 VWF GP1BA GP1BB TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct WFDC2 MECOM OSR1 FGF2 GATA3 HOXB4 ID4 BMP4 HOXA6 PAX8 LHX1 PLAC8 CTNNB1 NPNT PAX2 RET EMX2 PCDH19 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 MET GAB1 HGF PTPN11 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle SEL1L PRKCSH UBA52 RNF185 GANAB PDIA3 EDEM2 UBB UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN ITGA2 GXYLT2 CDH2 PXN SERPINE1 STT3B CDH1 SOX2 EDIL3 ZEB1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants FLT3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX12 PEX3 ACBD5 GDAP1 PEX13 PEX14 PXMP2 PXMP4 ABCD2 PEX11B ABCD3 PEX26 ABCD1 PEX2 ATAD1 PEX16 FIS1 PEX19 SLC25A17 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation B4GALT6 B4GALT4 B4GALT5 MGAT4A ST3GAL4 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 B4GALT2 B4GALT3 MGAT5 ST8SIA3 ST6GAL1 MGAT4C OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions TREM2 PLXNA2 ITGA1 SEMA3E SEMA4A CD72 SEMA5A SEMA4D PLXND1 PLXNC1 SEMA6A PLXNA4 SEMA6D PTPRC SEMA7A ITGB1 PLXNA1 TYROBP PLXNB3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry LY6E TIMD4 AP2A1 TYRO3 FURIN AP2A2 MERTK PIK3R1 UBA3 MAPRE3 EMC4 CD14 AP2M1 UBA1 HSPA5 CD33 HSPG2 CLDN1 CD209 SDC4 ATG7 SDC2 SDC3 AP2S1 AXL AGRN GPC1 AP2B1 UBA7 GPC3 HAVCR1 UBA6 GPC2 UBA5 MRC1 GPC5 GPC4 GPC6 RPSA PROS1 SDC1 CD300A GAS6 RNASEK RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 CDK2 LMNB1 MLH1 UBE2I FIGNL1 TEX12 TEX15 MSH4 MSH5 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B MND1 FIRRM REC8 BLM SYCP3 MRE11 BRCA1 BRCA2 STAG3 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 SPO11 H2BC12L H2BC21 SUN2 SUN1 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 SMC1A RAD50 SMC3 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 STAG1 H2BC11 STAG2 ATM RAD21 ATR H3C15 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS PTDSS2 PTDSS1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 CSNK1A1 PARP14 PARP8 UBA52 ST6GALNAC3 ST6GALNAC4 SRPK2 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD ITPR3 WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 PIK3CA VAV1 VAV2 IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 PLD4 V2-19 MAPK1 V1-11 PLD3 V1-16 V1-13 ELMO2 MAPK3 PLD2 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 PRKCD DOCK1 BRK1 LYN BTK CFL1 PLPP5 PLPP4 ACTB MYO5A YES1 HCK SYK PAK1 AHCYL1 FYN NCKAP1L WASF1 PRKCE PTK2 WASF2 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes IFI6 IKBKB IFI44L FKBP5 ARIH1 UBA7 HSPA5 RIGI CHUK ATF6 ISG15 IFIH1 UBE2L6 TRIM25 HERC5 IFI27 EIF2AK3 IKBKG RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors INSL3 INSL5 RXFP4 RXFP1 RLN2 RXFP2 RLN3 RXFP3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PTK6 CDKN1A CCND1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis SLC2A1 B4GALT1 LALBA SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine AMDHD2 GFPT2 GFPT1 PGM3 NAGK GNPNAT1 UAP1 RENBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) MBD4 PCNA SMUG1 PARP1 NEIL2 NEIL1 MPG PNKP LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 OGG1 RFC2 RFC1 PARP2 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLB POLE2 POLE3 PARG NTHL1 APEX1 TDG ADPRS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling HRAS SOS1 HBEGF SHC1 TGFA AREG EGF EGFR NRAS EREG BTC EPGN PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation JUN XIAP RNF146 USP7 MBD3 TNKS GATAD2B GATAD2A PREX2 PTEN CHD4 SNAI2 RCOR1 TRIM27 WWP2 EED NEDD4 MKRN1 FRK HDAC5 USP13 MTA2 HDAC7 RBBP4 MTA1 REST MTA3 RBBP7 TNKS2 PML AKT2 OTUD3 HDAC1 HDAC3 KDM1A MAPK1 MAPK3 ATF2 EGR1 RPTOR TNRC6C MOV10 MLST8 SLC38A9 CHD3 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 HDAC2 TNRC6A TNRC6B MTOR RNF2 PSMD8 RRAGA PSMD6 RRAGC SUZ12 CBX8 PSMD7 PHC2 RHEB RRAGB PHC1 PSMD2 RRAGD NR2E1 CBX4 PSMD3 LAMTOR2 AKT1 CBX2 LAMTOR1 PSMD1 PHC3 LAMTOR4 LAMTOR3 LAMTOR5 MECOM PSMA5 STUB1 PSMA6 PSMA3 PSMA4 ATN1 PSMA1 SALL4 MAF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 SNAI1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 PPARG AKT3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN NOS3 WASL DNM2 CAV1 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes CREBBP MAFK NFE2L2 ABCC3 EP300 ABCF2 ABCC1 ABCG2 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA ASCC2 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBE2D1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 UBB RPS17 RPS15A RPS16 RPS19 UBC RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 ZNF598 RPS24 RPS27 RPS23 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 IPPK ITPK1 IP6K1 NUDT3 NUDT4 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function SOX10 CTNNB1 JUP CDH19 CTNND1 ZC3H12A CTNNA1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ARAP1 UBC PTK6 RPS27A DOK1 CBL AKT1 UBA52 UBB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBIN HSP90AA1 ERBB2 CDC37 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH KGD4 DLST DLD PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing JUN H2BC9 H2AZ2 H4C9 SEL1L H2BC8 H2BC5 H2BC3 FURIN H2BC1 H2AC20 CCND1 ATP2A3 ATP2A2 MAMLD1 ATP2A1 RBPJ TMED2 TNRC6C RFNG MOV10 MFNG B4GALT1 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 ELANE E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 ST3GAL4 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A LFNG EP300 ST3GAL6 H3-3B H3C8 ST3GAL3 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins APBB1IP TLN1 CRK FN1 SRC BCAR1 RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 NTF4 NTRK2 BDNF PLCG1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 GNAS RAB11A AVP PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 CLOCK NPAS2 HELZ2 RAI1 CREBBP CHD9 NCOR1 MEF2C TBL1XR1 EP300 MED1 TGS1 MEF2D RORC RORA RORB SIRT1 PPARA CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNG13 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ABL1 ADCY1 SPP1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PRKACG PRKACA PRKACB STAT1 PECAM1 GNG3 GNG2 NFKBIA GNG5 GNG4 GNG7 GNA11 GNG8 GJA1 NOS3 PRR5 P2RX7 TRPV4 GNAS PKN2 CACNG7 CAPNS1 CAPNS2 CAPN2 RAMP2 PPP2R1B PPP2R1A CALCRL PIK3CB ADM PRKAR1B PRKAR2B PRKAR1A PRKAR2A PDPK1 CACNB2 PIK3CA P2RY2 ITGB3 ITGB1 MAPKAP1 ITGAV ITGA5 CACNA2D1 PIK3R2 NFKB1 PANX1 HSPG2 CTNNB1 CHUK PTPN1 CACNB1 CACNB3 IKBKB PPP2CA MLST8 MTOR IKBKE AKT1 CALM1 FLT4 KDR IKBKG ANXA2 TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD FYN CACNA1H GNG10 PTK2 GNG12 MMP14 GNG11 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 FZR1 SKP2 CCNE2 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 POLD3 POLD4 POLD1 POLE POLD2 RFC1 POLE4 POLE2 POLE3 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes AIM2 BCL2 RELA BCL2L1 NFKB1 HSP90AB1 NLRC4 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 NLRP1 PYCARD NLRP3 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription CREBBP RBPJ MAML2 FABP7 MAML1 KAT2B HEY1 KAT2A HES1 SNW1 EP300 WWC1 HEY2 DLGAP5 HES5 PTCRA PLXND1 PBX1 HEYL MAMLD1 MAML3 STAT1 NOTCH3 NOTCH1 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing ABHD17C FNTA ABHD17B BCL2L1 ABHD17A RCE1 NRAS PDE6D ICMT HRAS FNTB LYPLA1 PRKCQ ARL2 PRKG2 GOLGA7 KRAS USP17L2 CALM1 ZDHHC9 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism SLC26A2 SLC26A11 SLC26A1 PRKACG SLC2A1 PRKACA PRKACB G6PD B4GALT6 B4GALT5 FUT2 FUT1 TKFC B3GALT4 GALM PCK2 SLC37A1 G6PC2 G6PC3 FBP1 FBP2 SLC35B3 B4GAT1 LALBA SLC35B2 XYLT2 SLC35D2 XYLT1 B4GALNT2 B3GALT2 B3GALT1 FAM20B FUT4 FUT6 FUT5 FUT7 FUT9 B3GALT5 CHPF GALK1 PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 GALE CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 GCKR GCK PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 B3GAT3 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU B4GALT1 NDST4 TKT GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE NUP214 UBA52 MAN2B2 MAN2C1 UBB TALDO1 UBC ABCC5 RPS27A GAPDHS PGD PC GBE1 PYGM CEMIP STAB2 GYS2 LYVE1 PHKG1 HAS1 PHKG2 HYAL2 GYG2 HAS3 EPM2A GNS CHP1 AKR1E2 PHKA1 HAS2 SPAM1 PHKB PHKA2 PPP1R3C NHLRC1 GALT PYGB PYGL B3GALT6 SLC37A4 B4GALT7 ABO IDUA NCAN HEXB HEXA BGN AGL GLB1L3 DCN GLB1L2 BCAN NUP205 POM121 VCAN NUP107 GLB1L HYAL1 NUP188 GLB1 AAAS HYAL3 HYAL4 NUP160 POM121C AKR1B1 IDS CSPG5 NUP42 NUP85 CSPG4 TPR GUSB ARSB NUP62 GYG1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 GYS1 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RHCE PPP2R1B RHD PPP2R1A PGM2 PGM1 FUT3 PPP2R5D DERA G6PC1 B3GNT3 CHST14 DCXR AKR1A1 HSPG2 SORD CRYL1 XYLB MANBA GAA PCK1 ACAN LUM CD44 PPP2CA PPP2CB AGRN FMOD HK1 CALM1 GPI ADPGK ENO1 ENO2 ENO3 HK2 ENO4 HK3 TPI1 PGAM1 PGAM2 MAN2B1 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 ST6GALNAC6 PGK2 PFKL GNPDA1 GNPDA2 PFKM DSEL PFKP DSE UST CHST15 GLYCTK ST3GAL4 KHK SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 ST3GAL2 HMMR ST3GAL3 SLC9A1 UGP2 ALDH1A1 PRPS2 PRPS1 RPEL1 RPE CTSL SHPK PGLS PRPS1L1 RBKS SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 NUP107 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG DNMT1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B CHAT PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC18A3 SLC5A7 TSPOAP1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR2 GNPAT DHRS7B AGPS AWAT1 AWAT2 FAR1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport RHBG RHCG RHAG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases GUCY2C NHERF4 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle ARHGAP26 MPP7 VANGL1 ARHGAP32 ARHGEF7 PIK3R2 PIK3R1 RHOJ ARL13B CDC42 CPNE8 STEAP3 WIPF2 FMNL3 FNBP1L GJA1 FNBP1 SCRIB LAMTOR1 TFRC IQGAP3 SNAP23 ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 SYDE1 OPHN1 GIT1 TMPO DOCK8 WASL OCRL DEPDC1B CDC42EP1 VAMP3 RAB7A TRIO WAS NIPSNAP2 SLC1A5 ARHGAP21 PREX1 STOM PAK1 PAK3 CDC42BPB CDC42BPA PAK2 PAK4 DIAPH3 GIT2 CAV1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 POFUT2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 PSIP1 HMGA1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 RAC1 RAP1B RAPGEF1 RAP1A CRK MET GAB1 DOCK7 HGF CRKL DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events PPP2CA PPP2CB PPP1R1B PPP2R5D CDK5 PRKAR1B PRKAR2B PPP3CC PRKAR1A PDE4A PPP1CA PRKAR2A PDE4D PDE4C PPP3CA PRKACG PPP3CB PRKACA PRKACB PPP3R1 CALM1 PPP2R1B PPP2R1A SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling PRKCA SOS1 HBEGF SHC1 EGF ERBB2 EGFR NRAS NRG1 HRAS PRKCE EREG NRG3 NRG4 PTPN12 NRG2 BTC PRKCD MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer CDKN1A RPS6KB2 CDKN1B RICTOR CHUK FOXO4 BAD MLST8 FOXO6 FOXO1 AKT2 TSC2 MDM2 NR4A1 MTOR PRR5 PDPK1 FOXO3 AKT1S1 GSK3A AKT1 CASP9 GSK3B MAPKAP1 AKT3 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones RUVBL1 KANSL1 KANSL2 KANSL3 H2AC1 EP400 KAT7 ATXN7 SUPT20H ATXN7L3 TADA3 ING4 ING3 PAX3 OGT SUPT3H TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 WDR5 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2BC18 DMAP1 MRGBP TAF9 TADA1 VPS72 MSL2 MSL3 MSL1 TAF12 RBBP7 H2AC19 H2BC26 H2AC14 USP22 H2BC21 TAF10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 H2BC9 BRPF1 H4C9 BRPF3 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 ATF2 PHF20 ING5 SAP130 KAT8 TRRAP H2AC17 BRD1 H2AC12 KAT14 MEAF6 ZZZ3 HCFC1 TADA2A SGF29 NCOA2 TADA2B H2AC25 EPC1 H2AC21 KAT5 ACTB CLOCK ACTL6A CREBBP YEATS4 MBIP DR1 KAT2B KAT2A YEATS2 KAT6A MCRS1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation INS GRB10 IRS1 INSR IRS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells HRAS RASGRP3 NRAS RASGRP1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events CXCL6 CXCL9 CXCL8 TAS2R10 CXCL13 TAS2R13 CXCL3 TAS2R14 CXCL2 TAS2R16 ADCY9 CXCL5 CX3CL1 GNAL ADCY4 CXCL16 ADCY3 CCR9 ADCY2 CCR8 ADCY1 CCR7 ADCY8 KNG1 CCR4 ADCY7 CCR3 ADCY6 CCL13 ADCY5 CX3CR1 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCR6 CCL5 PPBP CXCR3 CCL4 RGSL1 OPN3 CCL1 RRH TAS2R40 CCL19 TAS2R41 CCR2 RGR TAS2R43 CCL16 OPN5 PLA2G4A TAS2R46 CCR10 CCL25 CCR1 CCL21 FPR2 CCL20 CXCL10 PDE1B CXCL11 RXFP4 PDE1A CXCL12 ITPR1 GPR17 ITPR2 ACKR3 TAS2R30 ITPR3 TAS2R31 CCL28 RXFP3 CCL27 PSAP TAS2R38 NMS PDYN NMU AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 SSTR3 GPR37 ANXA1 GPR31 PLCB4 GNAS GPR55 MTNR1A TAS2R50 MTNR1B MCHR1 RLN3 LPAR1 LPAR2 LPAR3 LPAR5 PPP3CC MT-RNR2 CHRM2 INSL5 PENK S1PR3 S1PR2 APLN GPR37L1 CHRM4 S1PR5 TAS2R19 S1PR4 PMCH TAS2R42 RGS4 TAS2R45 RGS5 PPY RGS3 RGS1 TAS2R60 CASR OXGR1 GAL MCHR2 NPB NPW NMUR2 NMUR1 NPY2R NPY1R APLNR PRKAR1B SUCNR1 BDKRB2 PRKAR2B HCAR2 BDKRB1 PRKAR1A HCAR3 PRKAR2A PRKX HCAR1 PPP3CA PPP3CB GNAT2 PYY RGS18 TAS2R9 RGS17 PLCB3 RGS19 PLCB1 HEBP1 RGS13 PLCB2 RGS16 P2RY12 GRM3 PPP3R1 P2RY13 P2RY14 GRM2 GRM7 P2RY4 RGS21 ADORA3 GRM6 ADORA1 GPER1 GRM8 NPY5R SSTR1 SSTR2 HRH4 SSTR4 SSTR5 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 HTR1E CNR2 CNR1 HTR1F OPRD1 HTR1D HTR1B ADRA2C HTR5A ADRA2B C5AR1 ADRA2A C5 TAS2R7 PTGDR2 PTGER3 TAS2R8 AGT GRM4 TAS2R1 TAS2R3 PRKCD TAS2R5 PRKCA TAS2R4 PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG GNG10 NBEA GNG12 GNG11 GNG13 GNB2 GNAQ C3 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 OPN1LW GNAZ GNA14 GNG3 CDK5 GNA15 OXER1 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 OPN1MW RGS11 RHO GNAT1 PPP2R1B PPP2R1A PPP2R5D NPY MAPK1 GNAT3 PPP2CA PPP2CB PPP1R1B CXCR1 CCL4L2 CXCR2 RGS8 CAMK2B PCP2 CAMK2D SRC GPSM1 GPSM2 CAMK2A PDE4A GPSM3 PDE4D PDE4C GNAI3 RGS14 RGS20 GNAI1 RGS22 RGS10 GNAI2 RGS12 OPRM1 SST CALM1 CAMK2G OPN1SW GABBR2 GABBR1 OPRK1 POMC CXCL1 PPP1CA TAS2R20 CAMK4 APP SAA1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 BDH2 BDH1 HMGCL HMGCS2 HMGCLL1 AACS ACAT1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 LYN PLCG2 PLCG1 EPO EPOR IRS2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain F8 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MTA2 ERCC6 RBBP4 MTA1 MBD3 MTA3 TTF1 RBBP7 H2AX EHMT2 GATAD2B GATAD2A H2AB1 H2AC19 H2BC26 H2AC14 CHD3 H2BC12L H2BC21 CBX3 H3-3B H3C8 HDAC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CHD4 H3C15 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD HNMT MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 HSPE1 HSPD1 ESR1 LONP1 CAT NRF1 DEFA5 HSF1 DNAJA1 HSPA1A SOD2 SIRT3 FOXO3 AKT1 HSPA9 HSPA1B HTRA2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH ADHFE1 D2HGDH NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown NUP85 PRKCA TPR NUP62 BANF1 PLK1 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 VRK1 CDK1 NUP153 LEMD2 NUP93 NUP50 NUP35 EMD NUP54 LMNB1 NUP37 LEMD3 CNEP1R1 LPIN1 LPIN2 LPIN3 PRKCB NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 S PHASE%REACTOME%R-HSA-69242.5 S Phase ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 CDCA5 RB1 CDKN1B FZR1 E2F1 RBBP4 SKP2 CABLES1 ESCO1 ESCO2 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 CKS1B MAX POLD3 POLD4 POLD1 POLE POLD2 RFC1 AKT2 PDS5B SMC1A SMC3 PDS5A WAPL POLE4 STAG1 STAG2 RAD21 POLE2 POLE3 PTK6 CDKN1A CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B RBL2 ANAPC15 ANAPC16 ANAPC7 CCNH UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones ATP6V0D1 SRPRB TPP1 PREB CXXC1 HDGF PPP2R5B KDELR3 SHC1 ADD1 DCTN1 HSPA5 SEC31A ERN1 EXTL2 PLA2G4B EXTL3 HYOU1 GSK3A ACADVL PDIA6 DNAJB11 SERP1 WFS1 TLN1 DNAJC3 CUL7 FKBP14 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 CTDSP2 SRPRA MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 TSFM MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 GFM1 MRPS17 MRPS15 MRPS16 MRPS14 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PHF20 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 MDM2 PSMC5 MDM4 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 GNE CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) FZD2 GNG13 FZD5 FZD7 WNT5A FZD4 GNB2 WNT16 FZD6 GNB1 WNT1 FZD1 GNB4 FZD8 GNB3 PTHLH GNB5 GNGT1 GNGT2 GIP IHH SMO PTCH1 GNG3 FZD10 GNG2 GNG5 GNG4 GNG7 CRHBP ADCYAP1 GNG8 ADCYAP1R1 CD55 WNT10A FZD9 UCN PTH1R UCN3 UCN2 PTH2R WNT7B GNAS CRH WNT7A GCGR GCG PTH2 WNT3A ADGRE5 ADGRE3 WNT9A GLP1R SHH VIPR1 DHH VIPR2 CRHR1 SCT WNT3 RAMP2 GIPR CALCA GHRHR GLP2R RAMP3 WNT8A CALCB WNT8B SCTR CALCR GHRH CALCRL VIP ADM2 ADM IAPP RAMP1 PTH WNT10B WNT9B WNT6 WNT4 WNT2 PTCH2 WNT2B ADGRE1 GNG10 ADGRE2 WNT11 GNG12 FZD3 GNG11 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic STX5 BET1L GOLIM4 RAB33B RAB41 GOLGA5 ARF1 NAPA NAPB COG8 COG7 COG6 STX16 NSF COG5 MAN2A1 COG4 GOSR1 COG3 NAPG COG2 COG1 CYTH3 RAB30 CYTH2 RAB36 CYTH4 CUX1 MAN1C1 SNAP29 STX6 MAN2A2 VTI1A CYTH1 RIC1 RAB39A RGP1 ALPP TRIP11 GOSR2 MAN1A2 VPS45 YKT6 MAN1A1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation B3GNT5 B4GALT6 B4GALT5 MMRN1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ADAMTS13 GALNT10 GALNT9 POMT2 GALNT8 B3GALNT2 B3GNT9 QTGAL SLC35A4 B3GNT8 FKRP CRPPA B3GNT6 GALNT1 POMT1 CHST4 POMGNT2 GCNT1 POMGNT1 GCNT3 B4GAT1 GCNT4 MGAT5B GCNT7 CHST10 GALNT7 GALNT6 POMK DAG1 GALNT5 RXYLT1 GALNT4 LARGE1 A4GNT LARGE2 GALNTL5 GALNTL6 FKTN GALNT2 POFUT2 B3GNT7 B3GNT4 B3GNT2 POFUT4 POFUT3 EMID1 MMRN2 MUC13 B3GNT3 GALNT12 SEMA5A SPON2 SEMA5B SPON1 ST6GALNAC2 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 ST6GAL1 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ST6GALNAC3 ADAMTS14 ST6GALNAC4 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification NR5A1 PCNA SEL1L RELA CP NPM1 RNF185 NR3C1 SP100 DERL1 DERL2 RNF5 RAB9A RAB9B OS9 VDR ARF4 IL6 SENP5 SENP2 NOP58 CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 SHISA5 PDIA6 MXRA8 SPARCL1 AURKA SCG2 GBF1 TGOLN2 STC2 PENK RAB11A IGFBP7 NDUFAB1 AMELX POMT2 WFS1 B3GALNT2 AMBN ZNF131 TMEM132A SLC35A4 FUCA2 UHRF2 FKRP HRC CRPPA DDX17 CASP8AP2 POMT1 MELTF MBD1 SERPINA10 POMGNT2 MIA3 SAFB POMGNT1 B4GAT1 MSLN TOPORS PRSS23 MGAT5B CHRDL1 CHST10 BMP15 POMK DAG1 RXYLT1 LARGE1 MEPE LARGE2 DNAJC3 B4GALNT2 RCN1 FKTN PIAS3 VGF ENAM AMTN VWA1 FAM20C FAM20A DDB1 MFGE8 UBE2V2 ITIH2 COPS7B SERPINC1 XPC AFP COPS7A FSTL1 FSTL3 CST3 APOL1 CUL4A TOP2B TOP1 SERPIND1 COPS3 GOLM1 POFUT2 COPS6 COPS5 NUCB1 NOTUM UBE2N POFUT4 COPS8 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGO DCTN6 PIGN DCTN5 PIGP DCTN1 PIGZ DCTN4 PIGW NR3C2 PIGV PIGY PIGX LRRC49 PIGC PIGB CAPZA3 PIGA PIGM PIGL CAPZA2 PIGG PIGF ACTR10 PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 SQSTM1 TTLL1 CHM TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H TFAP2B ING2 SPRN SPACA4 TFAP2C NICN1 UBE2I MDGA2 SUMO1 RECK MDGA1 NRN1 ART3 UBE2D2 ART4 UBE2D3 NTNG1 NTNG2 HIF3A RAB22A CD59 CD52 CD55 ELOB PRND ELOC RBX1 CNTN5 ALPL EPAS1 CNTN3 CNTN4 CUL2 ALPG HIF1A TEX101 VHL RAB40A RAB40B ZNF350 RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 ACTB PTP4A2 DCAF7 RTN4RL1 TTL TUBB6 RAB20 TUBB3 RAB25 TUBB1 RAB26 FBXO4 SVBP RAB23 FBXO6 RAB29 RAB15 RAB19 RAB17 FBXW4 TTLL10 FBXW5 NFU1 FBXW10 TTLL13 MEN1 TTLL11 FBXW7 TTLL12 FBXW9 IGFBP1 UMOD LIAS OTOA FBXW2 RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C TP53 LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FBXL3 EIF5A FBXL5 DHPS FN3KRP EIF5A2 TUBA1C FN3K TUBA1B ICMT DOHH TUBA1A TUBB2B FUCA1 TUBB2A USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 WDR5 RAB3D AAAS NUP160 POM121C NUP42 RAB44 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB31 NUP155 RAB37 NUP133 NUP210 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 HDAC7 NUP54 RAB6A TRAPPC1 RBBP5 RAB4B NUP37 RBBP7 CDC20 FCGR3B MRTFA PML DYNC1LI1 DYNC1LI2 RAB24 CDCA8 RAB10 RAB18 COMMD9 DYNLL1 PARP1 BST1 RANGAP1 VNN1 DYNLL2 CTSZ RHOA INCENP BIRC5 CTSC PRMT3 DYNC1I2 COMMD3 AURKB KCTD6 DYNC1I1 DYNC1H1 NR4A2 THRB TFG COPB1 NR2C1 THBS1 GOLGB1 NFKB2 FGA PLAUR FGG CAND1 ANK1 F7 F9 PROC F10 GGCX SKP1 CCNA2 PROS1 PROZ CCNA1 F2 GAS6 CUL1 DBT PCSK9 APOA2 APOA1 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB LAMB2 FN1 LAMB1 LAMC1 BTRC ADAMTS13 MTA1 RPS2 RPS6 EEF1A1 B4GALT2 B4GALT3 LRR1 CCNF B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B CDC34 PSME1 UBE2J2 SEC31A FBXL8 CALR FBXL4 LRRC41 GAN RRAGA SOCS2 SOCS6 KLHL2 KLHL3 IKBKE UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 CETN2 ACTR1A FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 CSNK1D FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 DCTN2 CUL7 CUL5 UBA6 DCTN3 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F YKT6 UBE2H KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W JMJD6 UBA3 RIOX2 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A ANO8 RNF168 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ANKRD28 ASPH ASB9 ASB6 ASB7 PPP6C PPP6R3 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 TP53BP1 GALNT1 ARFGAP3 ARFGAP2 COP1 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SMC1A SEC31B SMC3 TRAPPC2 SEC16B TRAPPC3 TPST2 KTN1 SEC16A STAG1 TPST1 TRAPPC5 TRAPPC9 STAG2 RAD21 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 TDG CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RAD52 RPL8 DCAF13 MATN3 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 HDAC4 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 AMER1 RPL27A AXIN1 APC CDC73 NCOA2 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PNPLA2 CTBP1 RWDD3 UBA2 DNMT1 SAE1 CREBBP AREG NFE2L2 DNMT3B TGFA DNMT3A EIF2AK2 STS MGAT3 ETF1 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG APOB ARSD UBE2L3 USO1 TUBB8 RAB2A TUBB8B SPTAN1 RAB1A RAB1B HGS RAB5A TOP2A GORASP1 UBE2T OTULIN FDX1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 FUT8 MITF GANAB ADAM10 MAN2A1 MGAT5 MGAT1 FBXL18 FBXL7 MGAT2 OST4 EDEM2 ARF3 MOGS DDOST SDC2 MGAT4C TMEM258 DAD1 OSTC MGAT4A TMED2 CANX MGAT4B STT3A STT3B MAN1B1 GPC3 TRRAP CCP110 KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR DCAF8 RNF128 DCAF5 VDAC3 DCAF4 VDAC2 PIAS4 DCAF6 VDAC1 WSB2 CFTR GATA3 OBSL1 BRCC3 DCUN1D5 SNX3 DCUN1D3 RHOT1 DCUN1D4 RCE1 DCUN1D1 DCUN1D2 ZRANB1 COMMD8 SIAH2 INO80 PUM2 ARF1 NPLOC4 STAM DDA1 TADA2B CYLD ANKRD9 H2AC25 UBXN7 COMMD2 H2AC21 COMMD1 BAP1 COMMD6 WDR48 OTUD7A COMMD7 OTUD7B COMMD4 BABAM1 COMMD5 RAB4A SPSB3 IFIH1 CCDC8 BABAM2 CISH UCHL1 TRIM4 CUL9 UIMC1 DPP3 UFD1 UBD IKBKG NAE1 SOCS5 TOMM70 RIPK2 WDTC1 ACTL6A CCDC22 JOSD2 COMMD10 TULP4 UCHL3 JOSD1 DCAF16 DCAF17 UCHL5 DDB2 FEM1C KAT2B DCAF10 KAT2A DCAF11 PTRH2 FEM1A FEM1B PRKN CAPZA1 WDR20 NEURL2 PSME2 NEDD8 ERCC8 USP17L21 USP17L20 GOSR2 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 USP17L12 ARFGAP1 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 PREB OTUD5 TOMM20 YY1 KDELR3 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS RWDD1 JMJD4 ADRB2 KDM8 FOXO4 VCPIP1 JMJD7 ATXN3 RIOX1 ATXN7 OGFOD1 DRG1 NLRP3 DRG2 RIPK1 RCCD1 SUDS3 CLSPN ZC3H15 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 STX5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 USP26 CAPZB USP20 USP21 RAB32 USP22 TAF10 RAB35 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 SCFD1 SPTBN1 RAB39B PARK7 MUC13 RAB8B INS RAB33A RAB7B FGF23 RAB21 CHML RAB11B RAB12 RAB13 ALPI GRIA1 HNRNPK CKAP4 SENP1 CALM1 UBE2C UBE2E1 UBE2D1 UBE2S CDK1 DLAT BLM PIGS BRCA1 PIGU PGAP1 PIGT WRN GPAA1 PIGK BARD1 CDH2 METTL21A KIN FBXW11 METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT RPA1 EEF1AKMT2 EEF1AKMT1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 DDX5 RAB41 KNG1 COG8 COG7 COG6 COG5 COG4 RAB27B COG3 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG MAN1A2 F5 F8 TMED3 MMRN1 MAN1A1 TMED7 TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B U2AF2 GALNT11 ARF5 GALNT14 NAPA GALNT13 NAPB GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GOSR1 NAPG GALNT8 GOLGA2 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 BPIFB2 GCNT1 GCNT3 GCNT4 GCNT7 MAN1C1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNT2 GALNTL6 ARCN1 COPG2 COPG1 LTBP1 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A COL7A1 MDC1 SPTB B4GALT1 DTL MYC ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 PSMD3 PSMD1 SPTBN2 NUP214 PSMD9 PSMD4 PSMA5 PSMD5 PPARGC1A PSMA6 PSMA3 PAAF1 PSME3 PSMA4 PSME4 PSMA1 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 UBA52 PSMG3 PSMG4 PSMD12 PSMG1 PSMD11 PSMG2 PSMD14 PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FOXL2 PSMC2 HIC1 SP3 PPARG PPARA LY6E PEX10 SRD5A3 PEX12 C3 PEX13 PEX14 FURIN BGLAP SPP1 IL33 RNF20 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC HLA-A RORA DLST VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT H2AC19 H2BC26 H2AC14 H2BC21 EP300 SOCS3 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RARA ETFB RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FBXO32 H2BC1 H2AC20 KDM1B NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 RABGGTB RABGGTA GALNT12 DPAGT1 SEMA5A ST6GALNAC1 SPON2 SEMA5B CMAS ST6GALNAC2 SPON1 THSD7B MPI ADAMTS4 HK1 ADAMTSL1 GMPPB NANP ADAMTS5 C1GALT1C1 FPGT ADAMTS2 GMPPA PGM3 ADAMTS3 ADAMTSL5 GNPNAT1 ADAMTSL4 GFUS NANS ADAMTS1 NUDT14 ADAMTSL3 ALG8 ADAMTSL2 ST6GAL1 MUC12 THSD7A ST6GAL2 ALG9 MUC15 ALG6 ADAMTS8 ALG5 ADAMTS9 ADAMTS6 SLC35C1 ADAMTS7 ALG14 ALG2 SBSPON ALG3 MUCL1 MUC3A ALG13 MUC5AC ALG12 MUC3B ALG11 ADAMTS20 ALG1 B3GLCT ALG10 CFP RENBP TRIM28 DHDDS THBS2 ADAMTS12 DPM1 THSD1 DPM2 THSD4 DPM3 ADAMTS10 RFT1 ADAMTS16 MVD ADAMTS15 ST6GALNAC3 ADAMTS14 ALG10B ST6GALNAC4 MUC1 ST6GALNAC5 MUC2 ADAMTS19 ST6GALNAC6 ADAMTS18 GNE ADAMTS17 UAP1 NPL MUC7 FUOM MUC4 NEU2 MUC6 NEU3 MUC16 NEU4 GALNT3 MUC17 DHRSX C1GALT1 GMDS AMDHD2 MUC19 NEU1 SSPOP MUC5B ST3GAL4 ST8SIA4 MUC20 MUC21 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 DPH1 ST3GAL2 DPH2 FBXL21P ST3GAL3 DPH3 MPDU1 DPH5 CTSA DNAJC24 DPH6 NUS1 SLC35A1 DPH7 PMM1 EEF2 ST8SIA1 UBXN1 ST8SIA2 NGLY1 GFPT2 RNF139 PMM2 MLEC ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor BAX NTRK3 NELFB DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing NTHL1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 FUT2 FUT1 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 ABO FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 RHCE RHD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence LIG1 BRCA1 TERT MCM5 MCM2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR CRLF1 TYK2 IL6ST LIF IL11 OSM OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA CTF1 CLCF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways TAS2R10 SEL1L TAS2R13 TAS2R14 TAS2R16 AVPR1B TAS2R40 AVPR2 TAS2R41 TAS2R43 AVPR1A TAS2R46 DERL2 ERLEC1 OS9 TAS2R30 TAS2R31 TAS2R38 TAS2R39 SSTR3 TAS2R50 MCHR1 PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 DNAJB1 GNA13 FGD3 PTGES3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 FKBP4 NGFR ARHGEF35 ARHGEF37 SOCS1 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 CYP26A1 MYD88 CYP26B1 CYP26C1 WWOX TAS2R7 TAS2R8 UBE2D2 UBE2D3 RBX1 EPAS1 HIF1A GRM4 VHL TAS2R1 TAS2R3 TAS2R5 TAS2R4 FES PIP5K1C POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 ACTB TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 CSNK2A1 CSNK2A2 CSNK2B TP53 ARL2 GNG10 CHD8 CBY1 GNG12 SOX3 GNG11 SOX17 GNG13 SRY CCT6A GNB2 SOX6 GNAQ SOX7 GNB1 SOX4 BCL9L CTNNBIP1 GNB4 SOX13 GNB3 PYGO1 BCL9 GNB5 PYGO2 GNGT1 ICMT TUBA1B GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 NUP107 AAAS NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 HECW1 ERCC6L ZWILCH KLHL12 BUB1B WNT3 ACTG1 CCDC88C CDC20 DACT1 WNT8A PPP1CC WNT8B PPP2R1B PPP2R1A CXXC4 KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B CHUK MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 MTMR4 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE DGKG CENPF DGKE DAGLA FMNL1 DGKD FMNL2 CENPH DGKB CENPI DGKA TAOK1 ABHD6 CENPK ABHD12 CENPL PRKCH CENPM DGKZ CENPN DGKQ DAGLB B9D2 CENPO DGKK CENPP DGKI CENPQ DGKH SPC24 SPC25 MAD2L1 DUSP8 CENPS DUSP9 FLT1 FLT4 MRAS KDR VEGFB PORCN VEGFC VEGFD PGF NF1 VEGFA DUSP10 ESRP1 GNA12 SHOC2 SPRED3 SPRED2 SPRED1 CCNT1 CD274 IL2RG NELFB KANK1 STRN MAP2K5 NCBP1 NRP2 NCBP2 CDH5 CDK9 ADH1C CRABP2 ADH1A LFNG CRABP1 JAG1 SDR16C5 ADH4 RDH11 RDH10 RDH16 WNT9B RDH14 RDH13 DLL1 AKR1C3 DHRS3 WNT4 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 SKP1 ALDH8A1 FGFRL1 CUL1 FLRT2 FLRT1 EVC2 IQCE EFCAB7 EVC BOC GAS1 NTRK3 DRC4 PMEPA1 BAMBI NTF3 CDON STRAP WWC1 NEURL1B DLGAP5 HES5 PTCRA RASGRP2 MIB2 RASGRP1 PBX1 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 TACC3 RAF1 PRKACA PRKACB RAPGEF3 RAPGEF4 CYSLTR1 TRPC7 TRPC6 PLCG2 TRPC3 RCOR1 LAMA5 LAMA2 SH3KBP1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 CHRM2 JAK3 CHRM3 CHRM1 CHRM4 CHRM5 HNRNPA1 LIMK2 RPS6 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GPNMB LRRK2 PTK6 RACK1 HBEGF TRAF1 HSP90AB1 TWF1 OPRD1 MSI2 RHOBTB2 ACTN1 TMOD3 LYPLA1 DDX39B RBCK1 PHIP FSHB INHBB INHBA INHA PRKAA1 PRKAA2 PTPRK EPS15L1 CAB39 EPN1 CAB39L PRKAG1 SPRY1 PRKAG2 PTPN3 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR LRRC41 FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 KBTBD7 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 FST ARHGDIB RAC3 FOXH1 ACVR1B EMD LBR ACVR2B GIT1 ACVR2A DRAP1 TMPO SWAP70 ACVR1C ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 RNF41 GARRE1 AMIGO2 NOXO1 CUL5 ARHGAP17 WDR83 SLC1A5 SYNGAP1 ARHGAP15 PAQR3 ARHGAP21 RGL3 LMAN1 RGL2 PAK1 PEA15 PGRMC2 DUSP5 RACGAP1 DUSP2 SLITRK3 DUSP1 NHS ABL2 IL17RD RAPGEF2 SLITRK5 DAB2IP NCKAP1L SEPTIN7 WASF1 CDC14B PAK2 RAG2 YKT6 RAG1 WASF2 PAK4 RASAL1 IL32 RASAL3 GIT2 RASGRP4 CAV1 RASGEF1A ETV4 MCAM RASA3 ERBIN RASA4 ARHGAP26 RASA2 BAIAP2 MPP7 ABHD17C VANGL1 IGF2BP1 MAPK6 ARHGAP32 MAPK4 ABI2 TAOK3 ANGPT1 NOXA1 ABHD17B ABHD17A ABI1 TEK NOX3 ESYT1 FERMT2 NOX1 TGFB1 UBE2M TGFBR1 TGFBR2 LMNB1 CPNE8 OXER1 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG TAX1BP1 FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 STMN1 ARHGAP33 RBFOX2 ARHGAP31 PDGFD DNMBP SHB ARHGAP30 MAP3K11 FGFBP3 FGFBP1 CDC42SE2 FGFBP2 DOCK6 ARHGAP9 ARF6 ARHGAP11B ALKAL2 ALKAL1 DUSP16 DOCK9 TIA1 DOCK8 TNK2 DOCK7 WASL ADAP1 ARHGAP4 ESRP2 SH3PXD2A PTPRZ1 RAMP2 TAGAP CSN2 CALCA PLEKHG3 TIAL1 RAMP3 PLEKHG4 SH2D2A CALCB PLEKHG1 PAG1 CALCR RANBP10 CALCRL ARAP1 GMIP ADM2 PTPRO ARFGAP3 PTN ADM ARFGAP2 IAPP AXL PLAT RAMP1 ARHGAP10 FAM83D CDC42EP5 FAM83A CDC42EP4 MXD4 CDC42EP3 LTK CDC42EP2 THBS4 WAS THBS3 PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B ITGAV COL4A2 NCAM1 ITGA5 COL4A1 PTPRS SPARC ITGB5 SERPINE1 SPOP ITGB6 ITGA2 ITGA8 TGFB2 TGFB3 COL9A1 COL9A3 COL9A2 CHD3 BMI1 RING1 HDAC4 HDAC2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 AMER1 NPHP4 GSK3B CSNK1A1 AXIN1 APC OPN1SW CDC73 LEO1 HHAT SHH DHH ATF1 CREBBP IRAK4 SP1 MAPKAPK3 BCL2 AREG BCL2L1 MYOG PTPN6 MYOD1 TACR2 MYF6 TACR3 TCF4 TAC3 TACR1 MYF5 TAC1 CAMK4 HHIP NTF4 S100B NTRK2 DISP2 SAA1 BDNF ULK3 SCUBE2 TAB3 DZIP1 TGFA TAB2 FOS SPOPL FOXO3 ELK1 PTK2 EREG UHMK1 BTC MC2R EPGN AKT3 JUN FZD7 WNT5A ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SPPL2B SPPL2A CX3CR1 ATP2A3 CLIP3 NSMAF ATP2A2 ATP2A1 PRKG2 OPN3 RRH PTGIR RGR PLA2G4A OPN5 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 RXFP2 RXFP3 CRHBP PDE11A CMKLR1 PDYN AGTR2 FPR3 GALR3 GALR2 NOS3 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 PTH1R UCN3 UCN2 GPR37 PDE10A GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR CDC14A MTNR1A MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 APLN GPR37L1 TAS2R19 KEL TAS2R42 HGS TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R DUSP4 SSTR1 DUSP3 SSTR2 VRK3 WNT16 DUSP6 SSTR4 DUSP7 SSTR5 CORT MAPK7 NPY4R OPRL1 PTHLH CNR2 CNR1 PIP5K1A TSHR PIP5K1B ACKR1 GOLGA7 ZDHHC9 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR TRRAP CCP110 AGT AR CFTR GATA3 SNX3 RHOT1 CSNK1G2 RCE1 ZRANB1 STAM CYLD OTUD7B RAB4A IKBKG RIPK2 UCHL5 KAT2B PIK3CD KAT2A NEDD8 USP9X USP17L2 RNF146 YY1 RUVBL1 MAP3K7 USP8 CER1 USP7 USP4 USP2 STAM2 VCP TNKS ADRB2 FOXO4 RIPK1 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MDM2 TAB1 USP34 PTEN TNFAIP3 ARRB1 RGL1 ARRB2 TRAF2 AXIN2 TRAF6 BIRC2 BIRC3 USP13 USP15 TNKS2 USP21 OTUD3 CKB GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PPP1R1B PDE3A CCL4L2 HNRNPM RGS8 SNW1 PDE8B PDE8A PCP2 HNRNPF GRK3 GRK6 GPSM1 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 PDE7B PDE7A HNRNPH1 MEMO1 CTNND1 AMH NOG CTNNA1 PPP1CA SNAI1 PPP1CB TERT USF1 DDX5 CCR5 CXCR4 NPFFR2 OXTR NPFFR1 RGSL1 GRPR EDNRA EDNRB PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT YBX1 NTSR1 PTBP1 NTSR2 GPR17 NMB XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GCGR GPR4 GCG MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 KIT RGS17 HTR2B RGS19 HTR2C RGS13 ADRB1 RGS16 P2RY6 ADRA1D HTR2A P2RY2 P2RY1 ADRA1B HTR4 RGS21 CCK ADRA1A HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 COL6A2 ADRA2C HTR5A ADRA2B COL4A4 TAAR1 COL6A1 ADRA2A GPR143 COL4A3 ADRB3 ATF2 COL6A3 RBPJ COL4A5 COL6A6 COL6A5 MEF2C B4GALT1 SPINT1 HPN SPINT2 HGFAC POGLUT1 POFUT1 MYL9 VPS29 VPS35 WLS VPS26A TMED5 TLE5 SFN COL1A2 EZH2 HEY1 CASP10 HEY2 MYLK HELLS KLF16 PPARG PPARD SPP1 RICTOR MBD3 STAT1 GATAD2B GATAD2A SKI CCNT2 CDC25C PRDM4 BEX3 CFLAR MAPKAPK5 KMT2B FOXO6 FOXO1 SOCS3 ACVRL1 BMPR2 AMHR2 GDF2 TNFRSF10B SMAD9 TNFRSF10A SMAD5 GREM2 ZFYVE16 BMPR1B NFKB1 BMPR1A TNFRSF10D PIN1 FASLG E2F4 E2F5 SST IL2RA STUB1 TRIM33 CCNK CCNC THBS2 GALNT3 MUC20 SH3GL3 EPS15 SH3GL2 SH3GL1 WWTR1 YES1 SMARCA4 SYVN1 CLTB YAP1 WNT5B ROR1 ROR2 PRICKLE1 RELA WNT1 FZD1 RYK FZD8 RHOT2 RXRG ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 ITCH KLC1 GPAM KLC4 KLC3 KLC2 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH NF2 ACTR3 PRDM1 ACTR2 NR3C1 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B IRAK1 KIF5A NCKIPSD RAP1GDS1 KDM4C IL2 IL3 IL6 BMP2 TCF3 YWHAE PRR5 LEP DPY30 CHD4 YWHAQ YWHAG YWHAH TGIF1 TBP TGIF2 EED STK4 SAV1 STK3 MOB1B MTA2 LATS1 MOB1A LATS2 AMOTL2 PENK AMOTL1 REST CARM1 KRAS CHRDL1 MMP2 MAML2 MAML1 VGF PIP4K2A PIP4K2B PIP4K2C JUNB RNF111 MED1 PRKCB FSTL1 FSTL3 PRKCQ MAML3 NOTUM CRKL MAPKAP1 NEDD4L SORCS3 CGA C3AR1 C5AR2 C5AR1 C5 RET RARG CD19 ASH2L GLI3 GLI2 RSPO3 CD55 TCF12 RARB CDKN2B WWP1 PTPN18 PF4 PTPN12 CSF2 PTPN7 PTPN2 MEN1 MST1 PGR MST1R FKBP5 ABL1 FPR1 SKIL CDK8 TIMP2 CDK5 WDR5 CRH HDAC5 HDAC8 HDAC9 HDAC6 HDAC7 GPR84 RAB6A RBBP4 RBBP5 RAB4B RBBP7 PML HDAC10 HDAC11 SOX2 SOX9 RUNX3 CITED1 PARP1 PRMT1 SGK1 PTPRJ NPY TJP1 FAS CDK5R1 ATP1B4 KCTD6 CXCR1 CBX6 CXCR2 SMURF1 SMAD6 ESR2 NR4A1 NR2E1 CASP2 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 POMC CXCL1 BAX PHB1 ARAF PEBP1 ADGRE5 CSK JAK2 ADGRE3 MARK3 FGB BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 TNS4 TNS3 SYK LCK FYN F2 DBT DLD CLTC CXCL6 CXCL9 CLTA CXCL8 CXCL13 AP2A1 CXCL3 CXCL2 AP2A2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 AP2M1 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 AP2S1 CCL22 CCL21 CCL20 CXCL10 CXCL11 CXCL12 ACKR4 ACKR3 ACKR2 AP2B1 CCL28 CCL27 P4HB POU2F1 STAT5A PXN FLNA GLI1 GRAP2 SUFU BTRC NUMB MTA1 MTA3 PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 GNAO1 NAB1 NAB2 LYL1 F3 DNM2 ARC TRIB1 TPH1 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 ID1 ID4 FOSB ID3 CDK5R2 TGFBR3 LRIG1 SOCS6 SH2B3 IKBKE BAG4 MATK GIPC1 ANOS1 WNT3A OFD1 LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 CSNK1E SFRP2 WIF1 SOST IRS4 IGF1R CILP KDM4B DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 OPN1LW CGN F11R PRKCZ PARD3 SMC1A SMC3 STAG1 STAG2 RAD21 NRG3 NRG4 NRG2 H3-4 ARL13B PDE6D FABP5 FABP7 PLIN3 MGLL GGA3 PDK4 RASGRP3 PIK3AP1 IL5RA CSF2RB CSF2RA STAT5B NCOA2 IL5 IL3RA IL2RB NCOA3 GRB2 NR5A2 CTBP2 CTBP1 DNMT1 PPP5C TNF WNT10B STAT6 PDGFRB FOXA1 ZDHHC7 TLE3 PPID CAV2 GREB1 CHD1 MMP7 TFF3 TFF1 ZDHHC21 CXXC5 USF2 ZNF217 EBAG9 SMPD3 SMPD2 PSAP GSK3A NTRK1 KIDINS220 CRK UBE2L3 TNFSF10 FADD PPP3CC C1QBP SPTAN1 BCAP31 TJP2 FNTA OTULIN TRADD CASP8 FLOT1 FLOT2 DSP DSG1 UACA GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 TMED2 FCER2 RFNG MFNG MDK ACTA2 LINGO1 MAG OMG RTN4 GPC5 ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 UCN CRHR2 TSHB LYN PIK3CG PIK3R6 PIK3R5 BTK RALA CFL1 JAK1 TYK2 AAMP MKNK1 SPRY2 ALK AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 GIP FFAR1 GNAZ ADORA2B JAG2 ADAM17 RDH5 CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 SNAI2 OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 PTPRU WWP2 WDR11 SH2B2 LETM1 CMA1 TMEM59 FER TEC VMA22 GRAP GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 RNF43 ZNRF3 FAM91A1 RSPO2 TEX2 RSPO1 ARMCX3 LGR6 PKP4 LGR5 RASAL2 KLB RSPO4 STIP1 LGR4 DDRGK1 FLT3 PLXNA1 IRS1 ANKRD26 PDE3B IRS2 NSFL1C CPD PIK3CB PLXNB1 TCIRG1 ARHGAP11A IDE FGF1 ZNF512B FGF2 CAPZB FGF3 EFHD2 NCK2 PTPRF FGF4 WDR6 FGF6 NCK1 FGF7 DST FGF9 PLEKHG6 AKT2 NIPSNAP2 BLTP3B GRB10 ATP6V1E1 PARD6B SH3BP1 CTSD WHAMM ATP6V1E2 HRAS WASF3 ATP6V1G1 NDUFA5 PCDH7 ATP6V0B ATP6V0E1 SEMA4F ATP6V1G2 PTPN13 ATP6AP1 VAPB PDPK1 GOLGA3 GAB1 BAIAP2L2 KCTD13 FLT3LG FRS2 TMEM87A GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 SCFD1 SPTBN1 TLR9 EPO EPOR PIK3C3 CCDC88A TRIB3 FRAT1 ANLN FRAT2 ATP6V0D1 FAF2 KIF14 SOS1 SH3RF1 ATP6V0C AKAP12 ATP6V0D2 ATP6V1B1 GFAP HINT2 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 RHOH PIK3R1 RHOF INS RHOJ NRAS RHOU ATP6V0A2 RHOV FGF20 RHOQ THEM4 SAMM50 EMC3 ATP6V1H MTX1 MAPK1 ATP6V0A4 CAVIN1 MYO9A ATP6V0E2 ATP6V1G3 TRIP10 FGF23 RTKN PRAG1 ATP6V1D FGF22 SYDE2 ATP6V1C1 BASP1 ALDH3A2 ATP6V1F ATP6V1C2 ELMO2 DDX4 ATP6V0A1 MAPK3 ARHGEF28 PTPN1 ARHGAP19 INSR ARHGAP18 TOR1AIP1 PTPN11 FGF16 ARHGAP12 PLD2 FGF19 RHPN1 FGF18 RHPN2 FGFR4 FGF10 FAM83B ACBD5 MACO1 SHARPIN ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 CAMK2B DLG5 PICALM CAMK2D SRC DOCK5 ACTN2 DOCK4 ABCD3 CAMK2A NRG1 DOCK3 SOWAHC GRIN2B MTR TNFAIP1 RND2 GRIN2D GRIN1 RND3 RND1 DLG1 CKAP4 DLG2 SENP1 ZAP70 DLG3 GFOD1 LRRC7 ALS2 DLG4 NEFL PEAK1 CALM1 NDUFS3 DOCK2 CAMK2G DOCK1 CCDC187 IER3 MECOM MOSPD2 FAM169A PHLPP2 ADD3 PLK1 PHLPP1 PTK2B CD86 UBE2D1 CD80 HSPE1 ATN1 SLC4A7 ACTC1 SALL4 MAF1 PDHB TRAT1 RPS6KB2 CDK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 GLP1R VIPR1 VIPR2 RANBP9 SCT KAT5 GIPR GHRHR CHEK1 GLP2R SCTR GHRH VIP OPTN PPP1R12A SEM1 APP HGF CLIP1 PDGFB KNG1 IGF2 IGF1 CCR6 PPBP CCR2 TIMP1 S100A9 S100A8 PLG PLPPR1 PLPPR2 PLPPR3 ELANE PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PDGFRA GTF2A1 GTF2A2 BMP10 LTBP4 P2RY12 P2RY13 P2RY14 P2RY4 LTBP3 ADORA3 ADORA1 LTBP1 SCD FASN ITGB8 ULK1 TCF7L2 CDKN1A TCF7L1 HDAC1 LEF1 TCF7 FLRT3 CCND1 SIN3A CDK2 CTNNB1 MET PPP1R15A PTPRA SPTB TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB HSPB1 PSMD8 PSMD6 PSMD7 SPTBN4 XPO1 SPTBN5 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 ARTN PRKCD PRKCA GFRA1 YWHAZ GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 PSMA4 GFRA4 PSMA1 PSMA2 MAPKAPK2 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 CASP9 MMP14 MMP16 CASP3 XIAP C3 DHRS4 FURIN PCSK6 NGF PCSK5 IL1RL1 IL33 RNF20 SPEN IFT172 CCT2 IFT52 CPSF7 ROCK1 IFT57 ROCK2 DYNC2H1 IFT140 GPS1 ADAM12 RPGRIP1L CUL3 TXNL1 KIF7 WDR35 RHOBTB1 SRRM1 IFT88 SMO COPS4 TRA2B GPR161 COPS2 INTU TULP3 MYO6 STK38 KIF3A TTC21B PDE5A RBBP6 PTCH1 WDR19 VIM HNRNPC IFT122 FUZ CCT7 ADCY10 RBMX MKS1 DBN1 DTX4 TBK1 ELMO1 CD28 OPN1MW RASGRF1 RNF31 SPATA2 TNFRSF1A LIN7B OTUD1 TRIM27 HSP90AA1 NEDD4 MKRN1 EGF FRK CBL EGFR CDC37 PLCG1 CDKN1B CCND3 FNTB E2F1 RHO E2F3 GNAT1 TFDP1 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L PELP1 H2BC21 DOK1 MYB EP300 SFPQ IL6R RASA1 KHDRBS1 H3-3B KHDRBS2 H3C8 KHDRBS3 H2AC8 H2AC6 STAP2 H2AC7 SRMS BCAR1 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RARA CBFB H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CETP KDM3A HDAC3 KDM1A KDM1B GNAT3 GPS2 RXRB NRIP1 APOD GABRG3 UGT1A3 APOE GABRG2 TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 GABRB3 NR1H3 GABRB2 NCOR2 ARL4C GABRB1 EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ABCG1 GNAI3 GNAI1 GNAI2 GABRQ GABBR2 GABRA1 GABBR1 ST3GAL4 ST3GAL6 AVP ST3GAL3 MEF2D TAS2R20 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 NKX2-5 KAT2B WWTR1 TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 CCN2 HIPK2 TBX5 GATA4 NPPA ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 ITGB4 COL15A1 ITGA6 PLEC COL11A1 COL11A2 LOX COL10A1 COL27A1 COL24A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL6A3 BMP1 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CTSS TLL2 TLL1 LAMB3 LAMA3 LAMC2 COL1A1 COL1A2 MMP9 PXDN MMP3 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME ABCC5 GSTA2 NUDT15 IMPDH1 HPRT1 IMPDH2 GMPS GSTA1 SLC28A2 RAC1 SLC29A1 TPMT VAV3 NME1 ABCC4 SLC29A2 SLC28A3 GSTM1 NME2 XDH VAV1 VAV2 GUK1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination YAP1 CYP51A1 POU3F1 MPZ SREBF2 ADGRG6 LAMA2 DRP2 HMGCR PRX LAMB1 LAMC1 PMP22 SOX10 NAB1 NAB2 UTRN EGR2 DAG1 POU3F2 MAG HDAC2 TEAD1 WWTR1 SMARCA4 SCD5 MBP ADGRV1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 TRIM27 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PML UBE2I PIAS1 SUMO1 MDM2 NUP205 POM121 NUP107 NUP188 AAAS VHL NUP160 NUP214 POM121C NUP42 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ1 KCNJ16 KCNJ10 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 CNGA2 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 GNG13 GNB1 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC9 METTL23 H4C9 H2BC8 H2BC26 H2BC5 H2BC3 H2BC12L H2BC21 NPM2 H2BC1 H3-3B SRPK1 H1-8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HIRA H2AX PRM2 PRM1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 HNRNPA2B1 SOD2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 MIF SOD1 MTAP GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 PPIA SNRPA1 PAK2 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 CHMP3 CFTR CHMP6 CHMP7 UBA52 ARL13B HBB HDAC6 PLIN2 IFT88 UBB UBC RPS27A PLIN3 CHMP4C CHMP4B VPS28 TSG101 HSPA8 CHMP4A VPS37C VPS37D VPS37A VPS37B CHMP2B MVB12B PCNT CHMP2A MVB12A UBAP1 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer NTRK3 NTF3 PDGFB RICTOR FOXO4 ESR1 MDM2 CD28 PRR5 PTEN GSK3A EGF EGFR CDKN1B KLB FLT3 IRS1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 PDGFRA RAC1 PDPK1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 MAPKAP1 HBEGF RAC2 RHOG PIK3R2 PIK3R1 CDKN1A FGF20 FGF23 FGF22 CHUK MET BAD PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 MLST8 TSC2 ESR2 SRC NR4A1 MTOR NRG1 AKT1S1 AKT1 PIK3AP1 GSK3B CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 RPS6KB2 PIK3R5 STRN PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA FOXO3 HGF EREG CASP9 BTC EPGN AKT3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism CYP27B1 GC PIAS4 CYP24A1 CYP2R1 LRP2 SUMO2 LGMN UBE2I VDR LDLRAP1 CUBN MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis PPIA HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 PARP1 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 FEN1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A POLQ GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALK1 PGM1 GALE GALM GALT AKR1B1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CCNB1 CDK1 ORC5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF COL4A2 COL4A1 SOS1 FURIN STAT3 PIK3R2 PIK3R1 PDGFB NRAS SPP1 COL6A2 COL4A4 COL6A1 COL4A3 STAT1 PTPN11 COL6A3 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 SRC PLG CRK STAT5A STAT5B THBS1 PLCG1 THBS2 PDGFD PTPN12 PIK3CB RAPGEF1 PLAT NCK2 NCK1 THBS4 RASA1 THBS3 PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis PEX3 ABCA10 ABCG4 ABCA3 ABCD2 ABCA6 ABCA2 ABCA5 ABCG1 ABCA9 ABCD3 ABCA7 APOA1 ABCD1 ABCA12 ABCG8 PEX19 ABCG5 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5PO SAMM50 MTX1 APOOL CHCHD3 DMAC2L HSPA9 ATP5MC2 ATP5MC3 ATP5MK ATP5MJ MICOS13 MT-ATP6 MICOS10 ATP5MC1 CHCHD6 ATP5MG ATP5MF ATP5ME APOO DNAJC11 IMMT TMEM11 ATP5F1A ATP5F1B ATP5PF MTX2 ATP5PD WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 CLTC CLTB PRKCA FZD4 WNT5A AP2S1 CLTA AP2A1 AP2A2 AP2B1 AP2M1 PRKCB DVL2 PRKCG ARRB2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation KDELR1 SEL1L RNF185 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 MGAT3 KDELR2 SAR1B COPB2 COPA TMED10 B4GALT6 DERL1 B4GALT5 DERL2 MAN2A2 SERPINA1 RNF5 OS9 COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 TMED7 TMED9 COPZ2 BET1L COPZ1 USO1 ARF5 NAPA GBF1 NAPB SPTAN1 RAB1A RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 GORASP1 B4GALNT2 ARCN1 COPG2 COPG1 B4GALT2 B4GALT3 B4GALT4 CGA RPN2 TUSC3 PRKCSH DCTN6 RPN1 DCTN5 DCTN1 MAGT1 DCTN4 FUT8 GANAB MAN2A1 MGAT5 CAPZA3 MGAT1 MGAT2 CAPZA2 COL7A1 OST4 EDEM2 ACTR10 MOGS ARF3 SEC31A DDOST MGAT4C TMEM258 DAD1 OSTC TMED2 MGAT4A CALR CANX SPTB MGAT4B STT3A STT3B B4GALT1 MAN1B1 ANK2 ANK3 CD59 CD55 SPTBN4 SPTBN5 SPTBN2 ASGR1 ASGR2 UBA52 ACTR1A ARF1 SPTA1 PDIA3 CSNK1D UBB UBC RPS27A CAPZA1 DCTN2 DCTN3 UMOD LMAN1 GOSR2 PSMC1 YKT6 ARFGAP1 PREB SRD5A3 KDELR3 VCP FUCA1 TRAPPC4 SEC22B LHB SEC23A SEC24B GLB1 SEC24A STX5 RAD23B ANKRD28 SEC13 PPP6C PPP6R3 SEC24D SEC24C TRAPPC1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 CTSZ DYNLL2 NSF CTSC DYNC1I2 DYNC1I1 DYNC1H1 GRIA1 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT TFG GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 COPB1 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS GOLGB1 DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 ANK1 SLC17A5 ST8SIA5 AREG ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 UBXN1 ST8SIA2 NGLY1 RNF139 GFPT2 MLEC PMM2 TGFA ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria BAX CYCS BAK1 GSDMD DIABLO GSDME DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBIN HSP90AA1 ERBB2 CDC37 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGA5 FN1 ITGB1 CEACAM1 CEACAM6 CEACAM8 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation SGSH AGRN NAGLU GPC1 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 HSPG2 SDC1 CTSL HPSE SDC4 HPSE2 SDC2 SDC3 IDS UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria E2F1 BBC3 TP63 TP73 PPP1R13B TP53 TFDP1 TFDP2 TP53BP2 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GUSB ARSB GYG1 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 ALDOB EPM2A DCXR GNS SI PPP1R3C LCT HGSNAT NHLRC1 GAA G6PC3 UBB SGSH UBC TALDO1 KHK RPS27A GALNS NAGLU SLC37A4 RPIA IDUA HYAL1 GLB1 IDS SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF10 LAMA5 FGF2 LAMA2 LAMB3 LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection AP2A1 AP2A2 NPM1 AP2M1 CCR5 CXCR4 AP2S1 AP2B1 TAF4B TBP TAF9 TAF1L NMT1 BTRC TAF15 TAF12 TAF13 TAF11 TAF8 KPNB1 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C CHMP4B CHMP4A RAC1 GTF2A1 CHMP2B GTF2A2 GTF2B CHMP2A GTF2E1 GTF2E2 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 TAF7L FEN1 PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 RNMT CCNH PSMA5 PSMA6 POLR2A PSMA3 POLR2B PSMA4 POLR2C PSMA1 POLR2D POLR2E RAN PSMA2 POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J ARF1 PSMD12 POLR2K PSMD11 POLR2L RNGTT GTF2H1 PSMD14 GTF2H2 GTF2H3 PSMD13 SUPT5H PSMA7 GTF2F1 GTF2H4 PSMB6 GTF2F2 GTF2H5 PSMB7 CDK7 ERCC3 PSMB4 ERCC2 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PPIA PSMC5 PSMC6 PSMC3 TAF9B PSMC4 PSMC1 PSMC2 PAK2 FURIN AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NMT2 LIG1 RCC1 TAF10 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 XRCC6 XRCC4 XRCC5 LIG4 RANGAP1 ATP6V1H DOCK2 CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 HCK SEM1 LCK FYN SKP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 EPB41L1 KCNMA1 KCNMB1 CASK KCNQ4 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A MYH9 TMC2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 USH1C SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters SLC17A1 SLC20A2 SLC34A3 SLC34A2 SLC20A1 SLC34A1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events H2BC9 CHMP3 H4C9 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 H2BC1 H2AC20 H2AC1 HNRNPK H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 H2BC18 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 NUP37 VPS36 VPS25 SNF8 CHMP1A H2AC19 H2BC26 H2AC14 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 CEBPD H2BC17 VPS4A CHMP2B H2BC12 MVB12B CHMP2A H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 H3C15 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport KDELR1 KDELR3 DYNLL1 FOLR1 INS BET1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 COG8 COG7 COG6 NSF COG5 COG4 COG3 CAPZA3 COG2 COG1 CAPZA2 DYNC1I2 ACTR10 ARF3 KDELR2 COPB2 COPA TMED10 TMED2 SPTB DYNC1I1 DYNC1H1 COPE ARF4 ANK2 ANK3 CD59 CD55 SPTBN4 TMED3 SPTBN5 SPTBN2 TMED7 TMED9 COPZ2 COPB1 BET1L STX5 COPZ1 USO1 ACTR1A ARF1 ARF5 GOLGB1 NAPA GBF1 NAPB SPTAN1 SPTA1 RAB1A RAB1B GOSR1 GOLGA2 NAPG ARFGAP3 ARFGAP2 CAPZB DYNC1LI1 GORASP1 ANK1 DYNC1LI2 ARCN1 DCTN2 CAPZA1 DCTN3 COPG2 GOSR2 COPG1 YKT6 TMEM115 ARFGAP1 SPTBN1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis B3GNT5 B4GALT6 B4GALT5 FUT2 FUT1 ST8SIA5 UGCG ST3GAL5 UGT8 ST3GAL2 ST3GAL3 B4GALNT1 GAL3ST1 CERK B3GALNT1 B3GALT4 ST6GALNAC5 ST6GALNAC6 A4GALT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RAPL1 IL1RL2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism GCDH HYKK AADAT PIPOX SLC25A21 CRYM AASS DHTKD1 ALDH7A1 DLST PHYKPL DLD TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR2 ARRB1 ARRB2 TGFBR3 TGFB2 TGFB1 GIPC1 TGFBR1 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease SOS1 CEP43 STAT3 PIK3R1 ERLIN2 NRAS FGF20 FGF23 FGF22 STAT1 FGF16 FGF18 FGFR4 FGF10 ZMYM2 FGFR1OP2 POLR2A BAG4 POLR2B STAT5A STAT5B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRIM24 PLCG1 POLR2I FGFR3 POLR2J POLR2K POLR2L GTF2F1 CPSF6 GTF2F2 FGFR1 MYO18A LRRFIP1 CUX1 BCR NCBP1 NCBP2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 GAB2 PIK3CA SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs RPS6KA1 CLTC CLTA AP2A1 AP2A2 FURIN NTRK3 PCSK6 NTF3 NGF PCSK5 AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB PTPRO VGF EP300 JUNB RAC1 HRAS GAB1 FRS2 MAP2K1 CRKL MAP2K2 PIK3CA TIAM1 SOS1 DUSP4 DUSP3 VRK3 PTPRS DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 PTPN11 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 SRC ADCYAP1 ADCYAP1R1 YWHAB SHC2 DOCK3 SHC3 RALGDS GRIN2B DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA BAX ATF1 NELFB BRAF MAP2K5 RAPGEF1 MAPKAPK3 FRS3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTF4 NTRK2 BDNF FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f MPDU1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS ABCC2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling PRKCA SOS1 SH2B2 LYN CBL PTPN6 YES1 LCK FYN KIT SOCS6 SH2B3 SOCS1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) PTPRO SOS1 PTPRS NTRK3 NTF3 PIK3R1 NRAS PLCG1 SRC BAX HRAS PIK3CA NELFB IRS1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A7 SLC4A4 AHCYL2 SLC4A8 SLC4A9 SLC4A10 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion INMT RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins OCLN APC DSG1 DSG3 PLEC ADD1 BIRC2 ROCK1 SPTAN1 LMNB1 CTNNB1 DBNL TJP1 ACIN1 GAS2 MAPT BCAP31 VIM GSN CLSPN TJP2 FNTA DSG2 PKP1 CDH1 BMX SATB1 STK24 STK26 PRKCQ CASP8 CASP6 PTK2 CASP7 DSP CASP3 PRKCD TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands IGFBP3 TNFRSF10C TP63 TP73 PPP1R13B TNFRSF10B TNFRSF10A FAS TP53 TMEM219 TNFRSF10D TP53BP2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR DLAT PDHX PDHA2 PDHA1 PDHB DLD GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR LYN STAT3 SOCS3 ADAM17 PTPN6 MAPK1 JAK2 SOCS2 CISH STAT1 MAPK3 PTPN1 SOCS1 IRS1 IRS2 GH1 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) SEL1L ERLIN1 ERLIN2 RNF185 VCP PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA1D GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY6 CACNA1C ADCY5 GNGT2 ADRA2C ADRA2A CACNB3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 GNAI1 CACNB2 GNAI2 GNG10 GNG12 GNG11 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA PRKCA ANP32A ELAVL1 XPO1 TNFSF13 NUP214 SET PRKCD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0D1 ATP6V1G1 ATP6V0B ATP6V0C ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V1H LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 CDH1 SH3GL1 CTNND1 UBA52 SRC STAM STAM2 CBLL1 CTNNB1 MET HGS UBB SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 ADCY9 TAS2R16 FZD8 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 PDE11A CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 PDE10A GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH TRIO MAS1 RASGRF2 XK ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 WNT6 VAV3 HCAR1 WNT2 ARHGEF11 PTCH2 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ WNT2B ARHGEF15 PLEKHG5 HEBP1 ADGRE1 ARHGEF17 GRM3 ARHGEF16 ADGRE2 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 WNT16 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN ACKR1 FGD1 FGD2 GNA13 FGD3 ABR FGD4 C5AR2 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 WNT3 WNT8A WNT8B PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 CCL11 CCL3L3 PRKACG CXCR5 CCR5 CXCR6 PRKACA CCL7 CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 RGSL1 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HBEGF HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA WNT3A WNT9A PAK1 C3 ROCK1 ROCK2 SMO PTCH1 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants CEP43 STAT5A STAT5B STAT3 PIK3R1 TRIM24 ZMYM2 CPSF6 FGFR1OP2 GAB2 MYO18A STAT1 PIK3CA LRRFIP1 CUX1 BCR FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 TEC IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 VAV3 PPP3CA PPP3CB PPP3R1 VAV1 VAV2 SOS1 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN BTK NFATC3 TXK SYK AHCYL1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation GCSH DLAT LIPT2 LIPT1 NDUFAB1 DLST FDX1 NFU1 DBT LIAS TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 PCNA UBC RFC3 RFC4 POLK RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly CHMP3 CHMP6 CHMP7 RANGAP1 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 PPP2CA TUBA3E TUBA3D TUBA3C UBE2I SUMO1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 TNPO1 NUP160 NUP85 NUP62 BANF1 SIRT2 NUP43 RAN NDC1 CCNB1 TUBB8 SEC13 NUP155 NUP133 IST1 VRK1 CDK1 LEMD2 NUP93 TUBB8B NUP35 EMD NUP54 LBR NUP37 KPNB1 SPAST CC2D1B LEMD3 PPP2R1A TUBB6 TUBB3 TUBB1 PPP2R2A CHMP4C RCC1 CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A CCNB2 AHCTF1 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 RXRB PLIN1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import PEX10 PEX12 PEX13 PEX14 SLC27A2 DHRS4 NUDT7 CRAT PECR ZFAND6 PEX26 SCP2 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 ECH1 PIPOX GNPAT ACOT2 ACOT4 UBE2D2 UBE2D3 NOS2 HACL1 HAO1 DECR2 HAO2 EPHX2 IDH1 TYSND1 UBE2D1 AMACR DAO CAT CROT UBA52 PEX2 PEX1 BAAT PEX7 UBB ACOX2 ACOX1 IDE UBC EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 AGXT PAOX HSD17B4 DDO HMGCL USP9X TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 PLK3 CNOT1 CNOT2 CNOT3 NPM1 CDC25C RGCC PLAGL1 TNKS1BP1 CNOT10 PLK2 CNOT8 CNOT9 CNOT6L CNOT11 TP53 BTG2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site CANX CALR INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling LCK JAK3 STAT5A STAT5B PTK2B SHC1 IL2RB JAK1 IL2RG IL2RA IL2 SYK BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA PHF1 H2BC9 H2AZ2 H4C9 JARID2 H2BC8 H2BC5 EED H2BC3 H2BC1 EPOP H2AC20 AEBP2 MTF2 RBBP4 EZH2 RBBP7 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EZHIP PHF19 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 EZH1 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 AR CFTR BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 NCOA2 PTK2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NCF1 ATP6V0D1 NCF2 ATP6V0C NCF4 ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H HVCN1 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F NOS1 ATP6V1C2 CYBB ATP6V0A1 CYBA LPO TCIRG1 SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B MPO ATP6V0E1 NOS2 ATP6V1G2 NOS3 ATP6V1B2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins NUP85 TPR PCNA NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 INCENP NUP50 BIRC5 NUP35 NUP54 NUP37 TOP2A AURKB PIAS3 SUMO3 SUMO2 UBE2I CDCA8 SUMO1 TOP2B TOP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle TRAK1 TRAK2 RHOT1 RAP1GDS1 MYO19 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS FMOD HEXB HEXA GNS GLB1L3 PRELP GLB1L2 OMD KERA GLB1L GLB1 ACAN OGN LUM RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 BRK1 ABI2 ABI1 ARPC1B ARPC1A ABL1 BTK MAPK1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ACTG1 MAPK3 ACTB CDC42 NCK1 WAS NCKIPSD WIPF1 WIPF2 CYFIP2 WIPF3 RAC1 WASF3 NCKAP1L WASF1 WASF2 PTK2 CYFIP1 NCKAP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PIP5K1C ARHGAP32 FURIN RPN2 PCSK6 JUP PRKCSH RPN1 GANAB CSNK2A3 PCSK7 CTNNB1 POMT2 SPCS3 SPCS2 SPCS1 OST4 SEC11A POMT1 SEC11C MOGS DDOST TMEM258 DAD1 OSTC CANX STT3A CDH1 CSNK2A1 CSNK2A2 ANK3 CSNK2B TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP BLM CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 CHTF18 RFC2 RFC1 STN1 RPA1 TEN1 RPA2 RPA3 DNA2 CTC1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 HRAS SOS1 NTF4 NTRK2 BDNF FRS3 FRS2 NRAS PTPN11 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism SLC2A1 CYB5R3 SLC2A3 CYB5A SLC23A2 SLC23A1 GSTO2 GSTO1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 PSIP1 PPIA HMGA1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release CANX CALR DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 GALK1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 IGHV3-23 V1-13 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-8 V1-20 IGHV3-33 IGKV1D-39 IGKV1D-33 V1-9 V5-4 IGKV2D-28 V1-7 IGKV4-1 V5-1 IGHV7-81 V1-5 V1-3 IGKV2D-30 V5-6 IGHV4-59 IGHV1-69 C1QB C1QA C1S IGLV2-11 C1R IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 V4-6 V4-2 IGKV3-15 V4-1 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 C1QC IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CRP IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair MBD4 H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 SMUG1 NEIL3 H2BC3 H3-4 PARP1 NEIL2 H2BC1 POT1 TERF2IP NEIL1 H2AC20 MPG FEN1 POLB H2AX PNKP LIG1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLE POLD2 OGG1 H2BC21 RFC2 RFC1 PARP2 LIG3 RPA1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 XRCC1 H2BC14 POLE4 H2AJ RPA3 H2BC15 H2BC11 POLE2 POLE3 PARG NTHL1 APEX1 ADPRS TDG MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 ABL1 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 MYBL2 DHFR TK1 CDKN2D CDKN2C CDKN1C RB1 DYRK1A CDKN1B CCND3 RRM2 CCND2 E2F1 RBBP4 E2F2 E2F3 SKP2 CABLES1 FBXO5 CDK6 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 TOP2A PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDKN2A CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN CCNB1 PSMA2 UBA52 CDKN2B PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 JAK2 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PPP2R2A PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBIN HSP90AA1 ERBB2 CDC37 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR FLRT1 SOS1 PIK3R1 NRAS FGF20 MAPK1 FLRT3 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 PTBP1 HNRNPM TGFBR3 HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L GIPC1 ANOS1 FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 SPRED2 SPRED1 ESRP2 KLB TIAL1 BRAF UBB GALNT3 PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 FMOD PRELP CHST6 OMD KERA ACAN OGN LUM ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions GJA10 PANX1 PANX2 GJD2 GJC1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation ARHGDIA NGFR NGF RHOA REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression CREBBP MAFK RELA NFE2L2 EP300 NFKB1 MYC NOTCH1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation ALDH1B1 ADH7 ACSS1 ADH5 ADH6 ADH1C ALDH1A1 ALDH2 ADH1A ADH4 ACSS2 ADH1B EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA1A XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGEF1 ARHGAP32 RHOC ARHGEF5 PIK3R1 RHOA ROCK1 CAVIN1 ROCK2 ABR RTKN ARHGEF28 ARHGAP18 MCF2 ACBD5 MACO1 FMNL3 ABCD3 FMNL2 ARHGDIA CIT ARHGEF25 CCDC187 PKN3 IQGAP1 TFRC IQGAP3 STX5 ARHGAP1 ARHGAP39 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK C1QBP LBR TMPO BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 LMAN1 STOM MCF2L ARHGEF40 RACGAP1 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 VAPB DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants HRAS NRAS KRAS SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border MSX1 DLX5 TFAP2A FGF4 TFAP2B BMP4 MYB TCF7L1 TFAP2C PAX7 POU5F1 SOX2 PAX3 ZIC1 WNT3A CTNNB1 GBX2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 TF CALU SERPINA1 MBTPS1 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 LAMB2 PDIA6 MXRA8 SPARCL1 FN1 LAMB1 SCG2 LAMC1 TGOLN2 STC2 PENK IGFBP7 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC GAS6 APLP2 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC22A5 PPARD CYP4B1 FAAH NUDT7 ACSM3 PCCA CRAT ECI1 PCCB THRSP ACSM6 PTGDS ACAD11 ACAD10 PLA2G4A GGT5 PTGES GGT1 DECR1 ALOX15B LTC4S GPX2 ACADL HADHB HADHA ACADVL ACADM ACADS CBR1 CYP2C9 NDUFAB1 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 SLC27A1 HACD1 TECR HSD17B3 PTGES2 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ACOT9 ELOVL1 OLAH CYP8B1 ELOVL4 ACOT7 ACSL1 MECR ELOVL5 ELOVL2 ACAA2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 HADH ACSL3 ACOT1 TECRL ACSF3 ACLY RXRA SCD FASN ACOT11 PPT1 ACOT12 ACSBG1 ACOT13 PPT2 SLC27A3 ACSBG2 SLC27A2 DPEP2 DPEP1 ALOX15 PECR THEM4 LTA4H PTGES3 CYP4F3 CYP4F8 SCP2 MCAT CYP2J2 NUDT19 ACBD7 PRXL2B ACBD6 ACOT7L ACAA1 ACBD4 PRKAA2 PHYH ACOT8 ACSF2 PRKAG2 MCEE ACBD5 PTGR1 ACOT2 CYP4A22 PTGR2 DBI ACOT4 PCTP ACOXL PRKAB2 ECHS1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 HACL1 PON3 HPGD DECR2 PON2 HAO2 PON1 EPHX2 FADS2 HPGDS FADS1 AMACR ALOX5AP MAPKAPK2 CROT CYP4F22 CPT2 MID1IP1 THEM5 SLC25A20 CPT1B ABCD1 CPT1A CYP4F11 SLC25A17 ACOX2 TBXAS1 EHHADH ACOX3 GPX1 GPX4 FAAH2 AKR1C3 HSD17B4 MMAA MMUT AWAT1 ALOXE3 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP3A7 CYP2E1 CYP2F1 ARNT AHRR CYP2W1 CYP2D6 ARNT2 CYP3A5 CYP2C18 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2J2 CYP2S1 CYP3A4 CYP1A2 CYP3A43 CYP2A7 CYP1A1 CYP2A6 AHR CYP2C19 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry AGRN ACE2 FURIN GPC1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 HSPG2 VCP TMPRSS2 NRP1 SDC1 CTSL SDC4 SDC2 SDC3 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus SQSTM1 UBC RPS27A NGF TRAF6 UBA52 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 MAPK8 ITGB3BP NGFR UBB FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 FGF23 FGF22 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B REST SRF NR3C1 KCNIP3 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members PMEPA1 FURIN BAMBI CER1 STRAP TGFB1 UBE2M TGFBR1 TGFBR2 SKIL SKI CDK8 SMAD2 TIMP2 SMAD1 SMAD4 SMAD3 YBX1 SMURF2 SMAD7 BMP2 TIMP1 CCNT2 TCF3 ARRB1 ARRB2 TGIF1 TGIF2 CBL USP15 TFDP1 TFDP2 PPP1CC CHRDL1 FGF2 EP300 JUNB PARD6A CGN F11R RNF111 PRKCZ PARD3 FSTL1 FSTL3 BMP10 LTBP4 RARA ITGB3 ARHGEF18 LTBP3 ITGB1 LTBP1 ITGAV NEDD4L RXRA ACVRL1 BMPR2 AMHR2 GDF2 SMAD9 ITGB8 SMAD5 ITGB5 SERPINE1 GREM2 ZFYVE16 PARP1 BMPR1B BMPR1A HDAC1 APH1A RHOA ITGB6 PSENEN MAPK1 NCSTN APH1B PSEN2 PSEN1 ITGA8 INHBB INHBA PPP1R15A INHA MAPK3 TGFB2 ATP1B4 TGFB3 NCOR2 TNRC6C MTMR4 MOV10 MYCN NCOR1 AGO3 AGO4 SNW1 MYC SMURF1 SMAD6 AGO1 TGFBR3 AGO2 TNRC6A TNRC6B E2F4 FKBP1A PPM1A E2F5 UBE2D3 TCF12 XPO1 RBL1 STUB1 UBE2D1 TRIM33 CCNK CCNC UBA52 AMH CDKN2B GIPC1 NOG COL1A2 FST PPP1CA FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C CCNT1 PPP1CB UBB UBC SP1 UCHL5 CDK9 RPS27A MYOG NEDD8 MEN1 MYOD1 WWTR1 MYF6 TCF4 MYF5 HELLS KLF16 USP9X MMP14 MMP16 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 CYP11A1 FDX1 FDX2 FDXR STARD3 STARD3NL AKR1B1 TSPOAP1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 MDC1 WEE1 YWHAB YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 YWHAZ SFN PIAS4 BRCC3 CCNB1 CDC25C CDK1 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 H2BC26 RFC3 RFC4 H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 CHEK2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 TP53 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase CDK2 BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants FLT3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis GAD1 GAD2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 RAD50 XRCC1 MRE11 BRCA2 FEN1 PARP1 PARP2 LIG3 RBBP8 NBN POLQ VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation PRKCA KDR ITPR1 ITPR2 ITPR3 RASA1 NRAS PLCG1 PRKCZ PRKCB HRAS AHCYL1 PDPK1 SPHK1 CALM1 PRKCD DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism SFTPA2 ABCA3 SFTPD SLC34A2 SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I VWF TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35A1 SLC35B2 SLC35B4 SLC35D1 SLC35C1 SLC35D2 SLC35A2 SLC35A3 SLC35B3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3 CREB3L4 CREB3L1 CREB3L2 MBTPS1 CREB3L3 CREBRF DCSTAMP MBTPS2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism TCN2 CD320 CUBN CBLIF MMAB AMN MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA AREG EGF EGFR PLCG1 EREG BTC EPGN LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations UGT2B7 CYP51A1 GSTA3 GSTA1 COMT CES3 HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CES1 FMO3 MAT1A CYP2C9 NNMT CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 AHCY SLC35D1 SLC35D2 CYP2D6 CMBL ALDH3A1 FDXR POR SULT2A1 CES2 MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 GSTM4 PTGES3 CYP4F3 CYP4F8 GSTK1 CHAC1 PODXL2 CYP27B1 ABHD14B SULT1A1 CYP26A1 SULT1C2 CYP26B1 SULT1B1 CYP24A1 SULT1E1 CYP26C1 CYP21A2 CYP2R1 BPNT2 AHRR BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 CYP4F12 PTGS1 NR1H4 AHR HPGDS CYP4F22 CYP19A1 GSTO1 CYP4F11 AIP NAT1 NAT2 TBXAS1 GSTA2 PAOX SULT1A3 GLYATL3 GLYATL2 ALDH2 GLYATL1 ACSM2A CYP3A4 ACSM5 GLYAT ACSM4 UGT1A9 CYB5B CYP4B1 CYB5R3 CYP27A1 CYP39A1 GSTP1 AOC1 MTRR CYP7B1 CYP7A1 MAT2B CYP8B1 TPST2 TPST1 CYP46A1 RXRA DPEP2 DPEP1 ARNT2 TPMT AS3MT AKR1A1 GSTT2 GSTT1 CYP11A1 ESD GSTT2B UGT1A3 GSTM3 CYP2J2 GSTM2 GSTM1 GSTM5 NCOA1 GSTO2 MAT2A GSTA5 GSTA4 CYP11B2 ARNT CYP4A22 ACSM1 ACSM2B PTGIS MTR NCOA2 POMC GSTZ1 CYP11B1 ADH1C ADH1A UGT1A10 UXS1 ADH4 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 ALDH1A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT2B17 UGDH UGT2B4 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A S100A9 LCN2 S100A8 LTF S100A7 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis ST3GAL4 FUT2 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism SLC26A2 SLC22A5 ABCB4 SLCO1B1 SLCO1B3 ABCD4 SLC2A1 SLC2A2 ABCC2 LMBRD1 ABCB11 OXA1L KGD4 NDUFAB1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 B4GAT1 TIAM2 CHST3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 PTGES3 B3GAT3 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UBE2I PIP5K1C ERCC2 GBA1 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GLYATL3 TP53 GLYATL2 GLYATL1 ACSM2A GNG10 ACSM5 GLYAT ACSM4 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 XDH GNA14 GNG3 GNA15 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 NUP37 PPP1CC PPP2R1B PPP2R1A PPA2 PPA1 RPS27 PPP2R5D DCXR AKR1A1 SORD CRYL1 XYLB IPPK IPMK ISYNA1 IP6K1 INPP1 IP6K2 NUDT3 NUDT4 VAC14 PI4K2B INPP5B MTMR10 NUDT11 PPP2CA NUDT10 PPP2CB MTMR2 MTMR12 INPP5A PIK3C2A IMPA1 PPIP5K1 MTMR4 MTM1 PLCZ1 IMPA2 INPP4A PPIP5K2 FIG4 PLCE1 INPP4B IP6K3 PIKFYVE MIOX INPP5F PI4K2A ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 ATIC OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS CPT2 GLUD1 MID1IP1 GLUD2 KYAT1 SLC25A20 CPT1B RIMKLA GLUL RIMKLB CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ADH1C ADH1A ADH4 RDH11 SIRT5 AKR1C3 MARCKS PRPS2 ALDH1A1 PRPS1 RPEL1 IDI1 MVK RPE SHPK TM7SF2 PGLS PMVK PRPS1L1 SC5D FDFT1 RBKS FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 NQO1 GSTA3 GSTA1 RAP1A PRKACG PRKACA PRKACB RAPGEF3 COMT BLVRB RAPGEF4 BLVRA CA12 CA1 CA3 CA5B CA2 CA5A CA4 CA7 CA6 CA9 CA14 CA13 PLCG2 GCHFR CHRM3 GCH1 SPR PTS PCK2 SLC37A1 G6PC2 G6PC3 RPS4Y2 FBP1 RPS27L FBP2 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 RPS24 B3GNT7 RPS23 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 GCKR GCK HSP90AB1 LYPLA1 CYGB DDAH1 PRKAA2 PRKAG2 PODXL2 ABHD14B SULT1A1 STK11 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 PRKAB2 SULT1A4 SULT4A1 SULT1A2 SULT1C4 MAN2B2 MAN2C1 LBR OCRL NAT1 NAT2 GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM ITPA CAV1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 HAS2 SPAM1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L SEC23A ASPA B3GALT6 B4GALT7 PNMT DDC TH DBH SEC24B SEC24A IQGAP1 PLD1 SEC24D SEC24C WASL TCN2 CD320 FUT3 TPST2 TPST1 NOSIP B3GNT3 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 AS3MT RPL32 GSTT2 HSPG2 RPL31 GSTT1 RPLP1 RPL34 ESD RPL10L GSTT2B GSTM3 RPL8 GSTM2 RPL10A GSTM1 RPL6 GSTM5 RPL7 GSTO2 RPL7A RPL18A MAT2A ACAN RPL36AL GSTA5 GSTA4 LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD RPL23 RPL22 RPL13A RPL9P9 SUMO2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 GPI ADPGK RPL26L1 ENO1 ENO2 ENO3 MRI1 ENOPH1 HK2 BHMT2 ENO4 HK3 BHMT ADI1 TPI1 PGAM1 PGAM2 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 PGK2 PFKL ECSIT GNPDA1 GNPDA2 PFKM PFKP CREBBP SP1 GLYCTK KHK GPT MED19 MED18 MED11 KCNJ11 ABCC8 ADCY9 ADCY4 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 MED21 ADCY6 ADCY5 CDK19 MED13L PRKG2 HEMK2 PLA2G4A GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC ITPR1 CHAC2 GGT3P ITPR2 GGT1 ITPR3 GCLM LRP8 APOB NOS3 CES1 DHFR TK1 GNAS HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC RAB5A KPNB1 TYMS SLC3A2 NSDHL LIPI CYP2D6 LIPH FDXR SULT2A1 STARD3 SLC36A4 ACOT9 STARD4 STARD5 ACOT7 MECR STARD6 STARD7 RUFY1 CH25H PRKD3 SLC6A12 FDX1 SLC7A5 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 CYP2E1 FAR2 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 HSD11B1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA CYP4F3 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE TSPO SPHK2 PTGR1 PTGR2 CYP21A2 AHRR SLC46A1 SAMD8 ECHS1 SGMS1 SGMS2 PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIAS4 VDAC1 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 ABHD4 ABHD3 INSIG2 INSIG1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 PLA2G12A CERS5 GPX1 ALDH1L1 CERS6 DHFR2 GPX4 FAAH2 MTHFR TNFRSF21 MTHFS ALDH1L2 CERS1 MTHFD1 CERS2 MTHFD1L PPM1L MTHFD2 HSD17B14 TPTE MTHFD2L LRP2 SLC25A32 CYP3A4 FOLR2 HSD17B11 SLC19A1 AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 TPH2 MBOAT1 ASMT DDHD2 AANAT MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PITPNB GBE1 CPNE7 PYGM ECI1 GYS2 PHKG1 CPNE6 PHKG2 GDE1 GYG2 ACSM6 CPNE1 EPM2A CPNE3 AKR1E2 PHKA1 PTGDS MFSD2B PHKB PHKA2 ACAD11 ACAD10 PPP1R3C MFSD2A NHLRC1 SACM1L SLC51A SLC51B PISD GALT CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS PANK4 CBR1 PCYT1B PANK2 PCYT1A PANK3 PANK1 STARD3NL DCAKD PLAAT1 PLAAT3 COASY PLAAT2 PPCDC CYP7B1 SLC25A16 NUDT8 PLAAT5 VNN2 PLAAT4 PPCS AKR1D1 ENPP2 GDPD1 ENPP3 ALOX12B GDPD3 SLC25A42 GDPD5 AASDHPPT HSD17B7 CYP7A1 MAT2B ORMDL2 HSD17B1 ORMDL3 HSD17B2 SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CKMT2 CYP8B1 GAMT GATM ETNPPL PLEKHA8 SLC6A7 PNPLA3 SLC6A8 PNPLA6 CKM CKMT1B ACAA2 INPPL1 SLC6A11 MSMO1 CKB CYP46A1 PLB1 ENPP6 SBF1 HADH SBF2 TPTE2 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PLA2G10 GPD1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 CHAT PLD4 PLD6 PLD3 ALDH3B2 EBP CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 ACBD6 ARG2 ACBD4 DGAT2L6 SLC25A2 CRLS1 ACSF2 CYP11B2 PI4KA DEGS1 ALPI DEGS2 PI4KB TNFAIP8 CYP4A22 DBI PCTP ACOXL ABCC3 PLA2G4F ABCC1 PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L PPP1CA NME1 PPP1CB MLXIPL FECH ACADSB ADIPOR1 ADIPOR2 NADK2 ACAD8 TYR UCKL1 DCT UCK2 UCK1 PUDP TK2 TYRP1 SLC5A8 SLC26A11 SLC26A1 ACO1 PLCB4 GCGR GCG SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLC5A6 COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ADSL PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS ADRA2C ADRA2A MT-CO1 B4GALT1 TKT SCO2 KCNG2 MT-CO2 MT-CO3 PPARGC1A PPARGC1B KCNC2 MED16 MED15 MED17 MED12 KCNB1 MED14 MED13 MED10 KCNS3 MED27 MED26 SIRT3 ALDH2 MED23 MED25 MED24 MED20 PPARG PPARA PPARD MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 RORA L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ODC1 ATP5MK COX11 AMD1 ATP5MJ OAZ1 COX14 SAT1 OAZ2 NDUFV3 SRM NDUFV2 ATP5MG OAZ3 MED30 NDUFV1 AZIN2 ATP5MF AZIN1 MED31 AGMAT ATP5ME SMS COA3 COA1 GOT1 UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 G6PC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 DMGDH NDUFB7 NDUFB6 CHDH SARDH COX4I1 NDUFB5 COX4I2 NDUFB4 ALDH7A1 SYT5 NDUFB3 NDUFB2 MLX ETFDH ALDH4A1 NDUFB1 PRODH FOXRED1 PRODH2 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 ARNT NDUFA6 FAHD1 NDUFA3 RRM2B NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 CCNC COX7B COX7C CTSL CAD COX8A DHODH SREBF1 UMPS COX8C COX5B COX5A COX6C GPAM COX6A1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C SAMHD1 VDR ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 PPM1K AUH QDPR IVD IL4I1 HIBCH PCBD1 ASRGL1 GALM RRM2 HGD TAT FAH HPD CARM1 LALBA NOSTRIN PNPO AOX1 XYLT2 XYLT1 B4GALNT2 NAMPT B3GALT2 PIP4K2A B3GALT1 PIP4K2B PIP4K2C FAM20B FUT4 FUT6 FUT5 FUT7 MED1 FUT9 B3GALT5 GALK1 PXYLP1 MED8 B3GAT2 B3GAT1 GALE MED4 MED6 MED7 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD CGA NR1D1 PIP4P1 GCSH SNAP25 GUK1 PAH GCDH HYKK AADAT SLC25A21 CRYM AASS CDA DHTKD1 CYB5A SLC23A2 SLC23A1 CIAO3 CIAO1 AFMID RIDA UROD NUDT13 NUDT12 NDOR1 NADK GNS UROS ALAS2 BCAT1 CYB5R3 DCTPP1 BCAT2 SLC45A2 ALDH6A1 KYAT3 ESRRA HIBADH THTPA NMRK2 TCN1 NMRK1 KMO PYGB COX10 NAXE PYGL PPOX CDK8 RRM1 NAXD HMBS ACMSD LHPP MMS19 MOCS2 MOCS3 RNLS TPK1 MOCOS CIAO2B SLC22A13 GSTP1 DTYMK HAAO GRHPR AOC1 TDO2 AGL IDO2 IDO1 QPRT SLC25A44 SLC25A51 SLC25A19 SLC25A28 SLC25A37 NUBP1 NUBP2 ENTPD2 GPX2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 GYG1 CD38 CPOX GPHN GLRX5 GLDC HOGA1 SLC19A3 SLC19A2 OCA2 SMARCD3 NMNAT3 NMNAT2 NMNAT1 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMT GLRX NADSYN1 NME3 NME4 ALAD DCTD TXNRD1 CMPK1 PGM2 KYNU CTPS2 CTPS1 PGM1 TTR COX7A2L TXN DERA BST1 VNN1 ARNT2 NFYA NFYB NFYC MANBA GAA NME2 BMAL1 CD44 COXFA4 COX7A2 COX7A1 SLC2A3 MAN2B1 POMC NAPRT PDXK GALNS UGT1A10 UXS1 UGT2B28 SLC9A1 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 BCKDK UGT2B15 BCKDHA UGT2B17 BCKDHB UGDH DBT UGT2B4 DLD UGT2B7 LDLRAP1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL LDLR GPIHBP1 MBTPS1 APOC3 ALB MBTPS2 FLAD1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 SERINC4 UCP1 HSD17B10 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA ALOX12 PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 PLCB3 CACNB2 PLCB1 PLCB2 CACNA1D DNM2 TPH1 EPRS1 TRMT112 CYP4F12 RAN ABCC5 ABCB7 NT5E ENTPD1 ENTPD5 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP RBP4 RBP1 LRAT ABO MMAB MTRR RTEL1 CBLIF MMACHC MMADHC INPP5E MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 LPIN2 MGLL LPIN3 PDK4 PEX11A CD36 NCOA2 NCOA6 NCOA3 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 PLIN2 BCO1 VKORC1 AKR1B10 CLPS PNPLA2 RBP2 LRP10 LRP12 PNLIP ADIPOQ DSEL DSE UST CHST15 ZDHHC21 ACSS3 AGPAT2 THRSP GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH TKFC ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 FMO3 NMT1 HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 SEPSECS QARS1 PSTK MARS1 INMT DARS1 SARS1 EEF1E1 AHCY KARS1 CBS IARS1 GNMT CTH SCLY CMBL ALDH3A1 POR CES2 BMX MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 APIP CYP2B6 EPHX1 CYP2S1 CYP4V2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 DUOX2 TSHB INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RPLP0 HSPA9 GSTO1 AIP TALDO1 MTAP GSTA2 AHCYL1 SULT1A3 MMAA MMUT PGD MCCC2 BTD PC PCCA HLCS MCCC1 PCCB ACACB FFAR1 TMLHE SHMT1 BBOX1 ALDH9A1 MTMR1 SHMT2 HMOX2 LETM1 GYS1 RHCE RHD PIK3CB NDUFA5 PTPN13 VAPB PIK3CA PIK3R3 PIK3C3 TRIB3 PIK3R4 PIK3R2 PIK3R1 STXBP1 INS THEM4 CACNB3 PLD2 CACNA1A ACBD5 CACNA1E ACSM1 ACSM2B MTR CALM1 NDUFS3 WDR26 PDHB RMND5B LDHA MPST TSTD1 MAEA SQOR PDPR GADL1 RMND5A SUOX ME1 NEK1 ADO CSAD PDK3 TXN2 DLAT TST PDK2 PDK1 ETHE1 PDHX SLC25A10 PDHA2 CDO1 PDHA1 GLP1R SIRT4 BRIP1 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 CYP11B1 HMMR SEM1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC PRSS3 PDZD11 PLA2G2A HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 CHPF OLAH CHSY1 ELOVL4 CHST11 ACSL1 ELOVL5 CHST12 CHSY3 ELOVL2 CHST13 SCD5 CSGALNACT1 ELOVL3 CHST7 ACSL6 CHPF2 ACSL5 CSGALNACT2 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 GSTK1 ASNS PHYH ACOT8 CHAC1 PIPOX BCS1L GNPAT ACOT2 STX1A ACOT4 COX19 COX17 ATP5MC1 PSMD8 HMOX1 PSMD6 HACL1 PSMD7 HAO1 CYC1 DECR2 PSMD2 HAO2 PSMD3 AKT1 PSMD1 NUP214 EPHX2 IDH1 PRKCA CS PSMA5 PSMA6 COQ2 PSMA3 AMACR PSMA4 DAO PSMA1 PXMP2 PSMA2 ACO2 MAPKAPK2 CROT UBA52 HSCB PSMD12 PSMD11 CACNA1C PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 TIMM21 BAAT UBB PSMB2 SLC25A17 ACOX2 PSMB3 UBC PSMB1 EHHADH AGPS PRSS1 RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PHYKPL ADRM1 CTRB2 PAOX CTRB1 NDUFB8 PSMC5 TAFAZZIN PSMC6 PSMC3 PSMC4 HSD17B4 PSMC1 PSMC2 DDO HMGCL ATP5F1A ATP5F1B IDH3G CYCS SRD5A3 NUDT7 VAPA CRAT IDUA NCAN HEXB HEXA LTC4S BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB HADHB HADHA ACADVL HSP90AA1 CYP17A1 PLCG1 NMT2 POLD1 EP300 RXRA HDAC3 GPS2 RXRB UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 NR1H2 NR1H3 NCOR2 NCOR1 TBL1XR1 FABP6 APOC2 PLIN1 HK1 AKAP5 GNAI1 GNAI2 MVD ST6GALNAC5 ST6GALNAC6 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 NEU1 CHD9 ST3GAL4 SLC17A5 ST8SIA5 ST3GAL5 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 TGS1 CTSA APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins OCLN DSG1 TJP2 DSG2 DSG3 CTNNB1 TJP1 PKP1 CDH1 DSP CASP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model SLC25A14 UCP1 UCP3 SLC25A27 UCP2 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm FOXF1 SHH IHH BMP4 GATA4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis CLTC CLTB CLTA DNASE2 CLVS2 CLVS1 ARF1 CTSZ BLOC1S1 GNS TXNDC5 HGS DNM2 AP4S1 AP4M1 AP1G2 DNAJC6 AP1G1 AP1S2 AP1S1 AP1S3 VAMP7 SH3GL2 AP1M2 HSPA8 AP1M1 VAMP2 AP1B1 VAMP8 APP CHMP2A AP4E1 M6PR ARRB1 AP4B1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SGTA STX5 STX1A VAPA VAMP2 BAG6 SERP1 SEC61G GET1 APP OTOF SEC61B HMOX1 GET3 EMD GET4 CAMLG UBL4A PRNP DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions ZNF217 STRAP HEYL ANGPTL4 TCF3 TGIF2 EED POMT2 POMT1 RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ANG RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ EML4 SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 NEK9 ZWINT NEK6 NEK7 KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 BTK GNGT1 GNG8 GNGT2 GNG10 GNG12 GNG11 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 ADORA2B GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B IL6 PRKAR1A PRKAR2A PRKX GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 DHFR TK1 RB1 CDKN1B RRM2 E2F1 RBBP4 SKP2 CABLES1 FBXO5 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 SOS1 YAP1 HBEGF GFAP SPARC SHC1 PIK3R1 NRAS APH1A ITCH PSENEN NCSTN APH1B PSEN2 PSEN1 GABRG3 APOE GABRG2 GABRB3 GABRB2 GABRB1 NCOR1 CXCL12 ESR1 WWOX ADAM17 SRC NRG1 DLG4 STAT5A NEDD4 GABRQ EGF EGFR GABRA1 UBA52 STMN1 WWP1 ADAP1 CSN2 UBB UBC RPS27A MXD4 HRAS S100B TAB2 EREG NRG3 PIK3CA PGR NRG4 NRG2 BTC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly COL17A1 ITGB4 LAMB3 CD151 ITGA6 PLEC DST LAMA3 LAMC2 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm OSR1 FGF2 FOXC2 FOXC1 BMP4 PAX8 PAX2 LHX1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 GSTZ1 PDP2 DLD FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway CENPX UBA52 MUS81 WDR48 SLX4 EME1 EME2 SLX1B FANCI UBB ATRIP FANCC UBC FANCD2 RPS27A DCLRE1B DCLRE1A FAAP100 UBE2T FAAP24 USP1 POLN FAAP20 FAN1 FANCM RPA1 FANCL FANCA RPA2 FANCB FANCE FANCG FANCF RPA3 ERCC4 ERCC1 ATR CENPS UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HBEGF HSP90AA1 CD9 HSP90AB1 TXNRD1 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family MUC15 MUC13 MUCL1 LYN MUC3A MUC5AC CLEC4C MUC3B CLEC4D MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 CLEC10A CLEC4A CLEC4E CLEC6A SYK FYN PLCG2 MUC12 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs CDC42 CTTN FLNA PPP1R12A PAK1 PAK3 LIMK1 RAC1 MYL12B MYL6 MYH9 MYLK MYH14 MYH11 MYH10 MYL9 NF2 PAK2 PPP1R12B PPP1CB CALM1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 DOCK3 RAC1 NTRK2 BDNF DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD SLC35D1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery SNRPD2 SNRPD1 SNRPD3 SNRPB SMN2 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 SNRPG RPS25 RPS28 RPS29 RPS20 FAU SNRPE RPS21 RPS24 RPS27 RPS23 SNRPF G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase E2F1 CDK2 E2F3 CCNA2 CCNA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes FMO3 CYP17A1 CYP4F22 CYP19A1 TPMT CYP7B1 MAT1A CYP11A1 CYP2U1 CYP1B1 CYP27A1 CYP11B2 AHCY CYP27B1 CYP11B1 TBXAS1 SLC35D1 CYP26B1 GSS OPLAH CYP24A1 CYP26C1 CYP2R1 CYP21A2 GCLC GGT1 GCLM FDXR ACY1 MAOA UGT1A4 FDX1 FDX2 UGT1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1 LHPP SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK PIK3CB SOS1 ALKAL2 ALKAL1 LTK TNK2 PIK3R2 PIK3R1 GRB2 PIK3CA IRS1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 GNG13 CDC42 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 ARHGEF6 GNG7 GNGT1 GNG8 PAK1 GNGT2 GNG10 GNG12 GNG11 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly NDOR1 RTEL1 POLD1 ABCB7 MMS19 BRIP1 ERCC2 CIAO3 CIAO1 NUBP1 NUBP2 CIAO2B VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways RELA NPM1 ITCH NR3C1 IRAK1 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 MED4 MED6 MED7 UBE2N VAV1 MAPKAP1 NEDD4L C4BPA C4BPB PTGES3 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB TAF7L FEN1 UBE2I SUMO1 C1QA C1S ELOB ELOC RBX1 VHL RNMT CCNH POLR2A ISCU POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 KPNA7 KPNA4 KPNA5 GBP1 KPNA3 CDK8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 PPP1CC PML DYNC1LI1 DYNC1LI2 RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 CD33 CHUK TJP1 DYNC1I2 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 BRD4 RPS18 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A TLR6 IKBKE IRF7 RAN NEK2 PDIA3 TUBB VPS36 VPS25 CBX1 SNF8 CHMP1A UBE2V1 CUL5 UBA7 UBA6 UBA5 UBR4 PAK2 IGF1R CAV1 UBA3 UBA1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A FXYD4 FXYD3 HYOU1 FXYD2 FXYD1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 NRP1 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 ARID4B SAP30 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD TAB3 TAB2 NFKBIB ELK1 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 SAP30L IFNA17 BAG2 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 PARP8 TUFM GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 DNAJC10 NMT1 VPS33B RIPK3 RAB5A KPNB1 TLR4 BCAP31 FNTA CHMP4C CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TAF9B KPNA2 MAP3K7 H2AC1 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA SCAP MAVS TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 CRNKL1 CDC40 ATP6V1H DHX9 CSTF3 CSTF2 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 DOCK2 CAMK2G HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 EFTUD2 PPP1CB CWC22 PAPOLA TXNL4A SNRPN ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 ACOT2 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B HSP90AA1 EGFR RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 CTSL ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 ATP7A ATP8B4 ATP8B3 ATP8B2 CAMK2B ATP8B1 SRI ATP4B CAMK2D ATP4A FXYD4 FXYD3 CAMK2A FXYD2 FXYD1 FXYD7 FXYD6 ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP7B CALM1 CAMK2G PDZD11 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants FLT3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GNAI3 GNAI1 GNAI2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development CLTB YAP1 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 MAG TEAD1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 POU3F1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 MBP ADGRV1 TYROBP DOCK1 MPZ ADGRG6 HMGCR ERBB2 PRX PMP22 SOX10 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM POU3F2 ANK1 SEM1 FYN CLTC CYP51A1 CLTA SREBF2 AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA2 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 SCD5 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 NAB1 MSI1 COL6A2 NAB2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 EGR2 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 DRP2 ROCK1 ROCK2 CNTN1 UTRN DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 HDAC2 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 WWTR1 YES1 SMARCA4 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CD4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism SLC26A2 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC CUBN AMN ABCD4 LMBRD1 GSS OPLAH GCLC GGT1 GCLM ACY1 SFTPD PPM1K AUH IVD HIBCH FMO3 GALM ADAMTS13 MAT1A POMT2 CYP2U1 G6PC3 POMT1 CYP1B1 POMGNT1 B4GAT1 AHCY DAG1 SLC35D1 LARGE1 APRT PNP ACACA HPRT1 FDXR ADA MAOA GALK1 CHSY1 GALE PRELP CHST6 OMD FDX1 KERA FDX2 NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 ACAT1 SFTPA2 MGAT2 PAPSS2 MOGS SDC4 SDC2 SDC3 B3GAT3 CYP27B1 SGSH CYP26B1 CYP24A1 CYP26C1 CYP21A2 CYP2R1 NAGLU B4GALT1 MAN1B1 ECHS1 GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 IDH1 UBA52 CYP4F22 CYP19A1 UBB TALDO1 UBC TBXAS1 RPS27A MMAA MMUT SFTPC PAH SRD5A3 MCCC2 BTD PC GBE1 PCCA HLCS MCCC1 GYS2 PCCB GYG2 EPM2A GNS PPP1R3C NHLRC1 CYP27A1 GALT B3GALT6 SLC37A4 B4GALT7 MMAB IDUA NCAN HEXB HEXA BGN DCN BCAN MTRR VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB GYG1 CYP17A1 GYS1 CYP7B1 PGM1 TCN2 CD320 CBLIF MMACHC MMADHC MUC13 G6PC1 SFTPB SFTA3 CHST14 SFTPA1 TPMT DCXR HSPG2 CYP11A1 GAA ACAN CYP11B2 LUM AGRN FMOD ABCA3 GALNT12 SEMA5A DPAGT1 SPON2 SEMA5B SPON1 THSD7B MPI MTR ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 CSF2RB THSD7A CSF2RA ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 ADAMTS12 DPM1 DPM2 THSD1 POMC ALDOB DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 SI MUC1 LCT MUC2 ADAMTS19 HGSNAT GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 CYP11B1 NEU1 SSPOP KHK MUC5B MUC20 MUC21 GALNS LFNG ST3GAL3 MPDU1 CTSA NUS1 UGT1A4 PMM2 GFPT1 DOLK SLC34A2 UGT1A1 BCKDK BCKDHA BCKDHB MC2R DBT DLD SLC25A15 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling LIFR CRLF1 TYK2 IL6ST STAT3 CBL SOCS3 IL6R LIF IL11 OSM IL6 OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA STAT1 CTF1 PTPN11 CLCF1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling FGF18 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 SPRED2 SPRED1 FGFRL1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding CLTC CLTB FTH1 CLTA FTL CTSZ BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 GNS SNAPIN AP3S1 TPD52 CLINT1 DNM2 AP4S1 AP4M1 AP1G2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 M6PR GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 STX4 SNAP23 DNASE2 CLVS2 IGF2R CLVS1 DTNBP1 ARF1 GOLGB1 NAPA RAB5C GBF1 TGOLN2 AP3B1 TXNDC5 HGS OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 APP CHMP2A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NEDD4L SERPINE1 FURIN PARP1 HDAC1 MAPK1 SKIL MAPK3 ATP1B4 SKI CDK8 NCOR2 SMAD2 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC E2F4 CCNT2 PPM1A E2F5 UBE2D3 RBL1 TGIF1 UBE2D1 TGIF2 TRIM33 CCNK CCNC UBA52 CDKN2B COL1A2 CCNT1 TFDP1 TFDP2 UBB UBC SP1 RPS27A CDK9 EP300 JUNB RNF111 MEN1 WWTR1 USP9X BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT FKBP1A NFATC2 NFATC3 PPP3CA PPP3CB NFATC1 PPP3R1 CALM1 PPIA GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI3 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 MCRIP1 SNAI2 KMT5A TGIF2 EED RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB CANX MGAT1 PRKCSH MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SNAPC5 SNAPC1 SNAPC2 SNAPC3 CCNT2 SNAPC4 ZNF143 PCF11 POU2F1 POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E SRRT POLR2F POLR2G POLR2H TAF9 POLR2I POLR2J POLR2K POLR2L TAF13 SUPT5H GTF2F1 TAF11 GTF2F2 ELL CDK7 CCNT1 TAF8 SUPT4H1 TAF6 TAF5 NCBP1 NCBP2 SP1 INTS1 INTS3 INTS2 CDK9 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 GTF2A1 ICE1 GTF2A2 ICE2 GTF2B SSU72 GTF2E1 GTF2E2 NABP2 NABP1 PHAX ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB1 DEFB104B DEFB109B DEFB136 DEFB135 DEFB134 CCR6 DEFB133 DEFB132 DEFB108B DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion CACNA1D GNG13 GNB2 GNAQ KCNJ11 GNB1 ABCC8 GNB4 GNB3 STXBP1 INS GNB5 ADCY8 GNGT1 ADCY6 ADCY5 GNGT2 RAP1A SLC2A1 PRKACG SLC2A2 PRKACA ADRA2C PRKACB RAPGEF3 SYT5 FFAR1 ADRA2A RAPGEF4 CACNB3 GNA14 CACNA1A CACNA1E STX1A GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 KCNG2 AKAP5 GNAI1 GNAI2 PRKCA IQGAP1 CD36 SNAP25 GNAS KCNC2 GCG CACNA1C CHRM3 GLP1R KCNB1 KCNS3 VAMP2 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CACNA2D2 MARCKS CACNB2 PLCB3 PLCB1 PLCB2 GNG10 ACSL4 ACSL3 GNG12 GNG11 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones HSPA5 MBTPS1 ATF6B MBTPS2 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM6 IRF1 NCAM1 TRIM5 IRF2 TRIM2 TRIM3 GBP1 CIITA HLA-H TRIM68 TRIM62 HLA-B TRIM46 HLA-C TRIM48 TRIM45 HLA-F TRIM35 HLA-G TRIM38 HLA-E OAS2 TRIM31 TRIM34 MAPK1 FCGR1BP IFI30 RAF1 TRIM29 TRIM26 TRIM22 MAPK3 MT2A TRIM17 SOCS1 PTPN1 IFNGR1 TRIM14 VCAM1 IFNGR2 TRIM10 PTPN11 SP100 CD44 MID1 YBX1 IRF8 B2M IRF6 IRF3 IRF9 SMAD7 CAMK2B PIAS1 HLA-A CAMK2D SUMO1 TRIM21 GBP5 CAMK2A GBP2 GBP6 GBP4 GBP3 TRIM25 IRF7 FCGR1A CAMK2G PRKCD IFNG PTAFR OASL OAS1 OAS3 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 JAK2 HLA-DRB4 JAK1 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 PML HLA-DQB1 ICAM1 SOCS3 PTPN6 IRF4 IRF5 GBP7 TRIM8 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) ATP6V0D1 SRPRB TPP1 PREB CXXC1 CXCL8 HDGF PPP2R5B KDELR3 SHC1 CREB3L3 ADD1 DCTN1 HSPA5 NFYA NFYB NFYC ATF6 CEBPB HERPUD1 CEBPG CCL2 ASNS SEC31A EIF2S2 EIF2S1 ERN1 EIF2S3 DDIT3 CREB3 CREB3L4 CREB3L1 ATF3 CREB3L2 ATF4 CALR EXTL2 MBTPS1 CREBRF DCSTAMP ATF6B MBTPS2 PLA2G4B EXTL3 HYOU1 KHSRP GSK3A EIF2AK3 DIS3 ACADVL PDIA6 DNAJB11 DCP2 SERP1 PARN WFS1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 TLN1 EXOSC8 DNAJC3 EXOSC3 EXOSC2 EXOSC1 CUL7 FKBP14 IGFBP1 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 HSP90B1 CTDSP2 SRPRA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema KLKB1 F2 F12 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A CPSF4 CHTOP CPSF7 CPSF1 FUS ALYREF CPSF3 CPSF2 SRRM1 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 CDC40 DDX39A ZC3H11A SARNP DHX9 DDX39B CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 UPF3B MAGOHB HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SLU7 SF3B4 FYTTD1 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 CASC3 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG13 GNB2 GNB1 GRIK3 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) YAP1 CREBBP DPPA4 DPPA2 LEUTX KDM4E EP300 TPRX1 TPRX2 ZSCAN4 TEAD4 TUT7 TUT4 DUX4 TP53 TPRXL DUXA DUXB AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC NQO1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 PPM1K SDSL AUH IVD QDPR SERINC2 IL4I1 PSPH HIBCH SERINC5 PCBD1 ASRGL1 SERINC4 HNMT SEPHS2 KGD4 RARS1 SECISBP2 MAT1A LARS1 HGD NNMT TAT FAH EEFSEC HPD AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 RPS17 SARS1 HSD17B10 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT SLC3A2 RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 SLC36A4 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 APIP RPS20 SLC6A12 HAL FAU RPS21 CARNMT1 RPS24 SLC7A5 UROC1 RPS23 AMDHD1 HDC CARNS1 FTCD CGA FMO1 ACAT1 PAPSS2 PAPSS1 ASNS TPH1 PIPOX EPRS1 ECHS1 PSMD8 PSMD6 PSMD7 HAO1 PSMD2 PSMD3 PSMD1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO GCSH PSMA5 IYD PSMA6 DUOXA1 PSMA3 DUOXA2 PSMA4 DUOX2 PSMA1 DAO TSHB PXMP2 PSMA2 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A MTAP SLC25A12 AGXT PHYKPL SLC25A13 ADRM1 PAOX PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DDO TP53 CAV1 GCDH PAH HYKK TPH2 AADAT ASMT SLC25A21 AANAT CRYM AASS DHTKD1 MCCC2 AFMID MCCC1 RIDA BCAT1 AGXT2 BCAT2 SLC45A2 ALDH6A1 KYAT3 HIBADH KMO OGDH FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA ACMSD TMLHE SHMT1 BBOX1 ALDH9A1 PNMT HAAO GRHPR DDC TDO2 TH IDO2 DBH IDO1 SLC25A44 MTRR DLST SLC44A1 GLDC HOGA1 OCA2 AMT TXNRD1 KYNU ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM OAZ3 AZIN2 AZIN1 AGMAT CKMT2 GAMT SMS GATM SLC6A7 GOT1 SLC6A8 CKM CKMT1B SLC6A11 CKB RPS27 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 DMGDH RPLP1 RPL34 CHDH RPL10L SARDH RPL8 ALDH7A1 RPL10A RPL6 RPL7 ARG2 ALDH4A1 PRODH SLC25A2 RPL7A RPL18A PRODH2 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 MTR RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MRI1 ENOPH1 BHMT2 BHMT OAT ADI1 GLS2 GOT2 PYCR1 MPST TSTD1 PYCR2 PYCR3 SQOR GLS GADL1 GLUD1 SUOX GLUD2 ADO KYAT1 CSAD RIMKLA TXN2 GLUL TST ETHE1 RIMKLB SLC25A10 CDO1 GSTZ1 ACADSB ACAD8 TYR SIRT5 DCT SEM1 TYRP1 GPT BCKDK BCKDHA BCKDHB DBT DLD SLC25A15 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) OPN1MW OPN1LW DHRS3 OPN1SW RBP3 AWAT2 RLBP1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle CS ISCA2 ISCA1 ACO2 FXN ACAT1 LYRM4 SDHAF2 SDHAF3 SDHAF1 CSKMT SDHAF4 IDH2 SDHC SDHD SIRT3 SDHA SDHB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation MAPKAPK3 MAP3K7 IRAK1 UBE2V1 MAPKAPK2 TRAF6 MAPK14 MAPK11 IRAK2 TAB1 TAB3 TAB2 NOD1 MAP2K6 NOD2 UBE2N IKBKG MAP2K3 RIPK2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs HACD1 ACSBG1 TECR HSD17B3 SLC27A3 HSD17B12 ACSBG2 HACD3 HACD2 HACD4 ELOVL1 ELOVL4 ACSL1 ELOVL5 ELOVL2 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER PCNA PARP1 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 DDB2 POLD2 POLE RFC2 RFC1 PARP2 RPA1 CHD1L RPA2 DDB1 XPA POLE4 CUL4A RPA3 RBX1 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 GCN1 RPS19 RPS18 EIF2AK4 RPS3 RPS2 RPS11 IMPACT RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 TRIB3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A CEBPB RPL6 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPL37 ATF3 ATF4 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking WNT5B WNT5A PORCN WNT7B WNT16 WNT1 WNT7A SNX3 WNT3A WNT9A WNT3 WNT8A WNT8B WNT10B WNT9B WNT6 WNT4 WNT2 WNT2B WNT10A VPS29 WNT11 VPS35 WLS VPS26A TMED5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB2 VDAC1 MAIP1 PARL AFG3L2 LETM1 SMDT1 YME1L1 PMPCB PMPCA MICU3 AKAP1 MICU2 MICU1 MCU PHB1 SLC8B1 SLC8A3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PDE6G GNB1 GNGT1 APOA2 APOA1 APOA4 HSPG2 APOE SDC4 SDC2 SDC3 LPL RBP4 RDH12 OPN1LW RBP1 LRAT LDLR AGRN STRA6 GPIHBP1 GPC1 APOC3 APOC2 RDH5 GPC3 RLBP1 LRP8 GPC2 GPC5 GPC4 GPC6 OPN1MW APOB RPE65 SDC1 CALM1 PRKCA RDH8 OPN1SW GUCY2D GUCA1B GUCA1A GUCA1C LRP1 GUCY2F NMT1 RETSAT GRK1 APOM GRK7 FNTB RHO BCO2 CNGA1 BCO1 GNAT1 RCVRN AKR1B10 CAMKMT CLPS RBP2 RGS9BP SLC24A1 SAG LRP10 NMT2 LRP12 RBP3 PPEF1 PNLIP HSD17B6 METAP1 METAP2 CNGB1 HSD17B1 FNTA AKR1C1 TTR RDH11 RDH10 ABCA4 AKR1C4 RDH16 AKR1C3 SDR9C7 DHRS3 MYO7A DHRS9 PRKCQ LRP2 PLB1 CYP4V2 AWAT2 PDE6B PDE6A CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CALM1 CAMK2G ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS PLA2G2D OSBPL10 PLA2G2E MBOAT1 PLA1A PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLAAT3 PLA2G2A OSBPL8 PLA2G1B OSBPL5 LPCAT4 LPCAT3 PLA2G2F PLA2G4A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS SOS1 HBEGF TGFA AREG EGF EGFR NRAS EREG BTC EPGN DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 MAP3K7 IRAK1 UBE2V1 TRAF6 MAPK9 IRAK2 TAB1 MAP2K7 MAPK10 MAPK8 TAB3 TAB2 NOD1 NOD2 UBE2N IKBKG RIPK2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 RUVBL1 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 POLR2A POLR2B POLR2C POLR2D NHP2 POLR2E POLR2F ANKRD28 POLR2G NOP10 POLR2H POLR2I POLR2J POLR2K PPP6C POLR2L PPP6R3 BLM RTEL1 CHTF8 DAXX ATRX WRN PRIM2 PRIM1 H2AX POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC2 TERT RFC1 H3-3B STN1 RPA1 TEN1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ RPA3 H2BC15 CCNA2 CCNA1 H2BC11 DNA2 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BRD7 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SMARCE1 ACTB ARID2 PBRM1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 BCL2L1 NLRP1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors PRKCA TSPAN7 AP2A1 GRIA1 GRIA2 PRKCB GRIP1 NSF PICK1 PRKCG GRIP2 GRIA3 GRIA4 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia F9 F10 F8 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 RPS6KA2 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle ARHGAP26 AKAP12 HINT2 VANGL1 ARHGAP32 PIK3R2 PIK3R1 RHOD ESYT1 ACTN1 LMNB1 TOR1AIP1 ARHGAP12 DBN1 CPNE8 STEAP3 ANKFY1 GOLGA8R MOSPD2 ADD3 ARHGAP1 SLC4A7 ARHGAP39 ARHGAP5 ARHGAP35 FILIP1 STBD1 EMD LBR TMPO VRK2 PLXNA1 LEMD3 DEPDC1B PLXNB1 CAPZB VAMP3 EFHD2 RAB7A ARHGAP17 ARHGAP21 PAK6 LMAN1 WHAMM PGRMC2 PAK5 RACGAP1 VAPB DIAPH1 DIAPH3 CAV1 MCAM CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway RELA MALT1 CASP8 NFKB1 IL1B PYCARD INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLST DLD SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function CDH24 ADAM33 ADAM19 CTNNB1 CDH11 JUP ANGPTL4 CTNND1 CDH8 CTNNA1 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance APOA1 HDLBP CUBN AMN MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase LMNB1 NCAPG2 SMC4 SMC2 NCAPH2 NCAPD3 MCPH1 NUP205 POM121 NUP107 NUP188 KMT5A AAAS NUP160 POM121C ARPP19 NUP42 NUP85 TPR ENSA NUP62 BANF1 NUP88 USO1 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB2A NUP155 NUP133 RB1 NUP210 VRK1 LEMD2 NUP153 NUP93 NUMA1 NUP50 NUP35 NUP54 RAB1A RAB1B GOLGA2 NUP37 BLZF1 PPP2R1B H2AX CNEP1R1 PPP2R1A H2AB1 MASTL H2AC19 GORASP2 H2BC26 GORASP1 H2AC14 PPP2R2D H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 MAPK1 PPP2CA PPP2CB LPIN1 LPIN2 LPIN3 NUP214 PRKCA PLK1 CCNB1 CDK1 SET EMD LEMD3 CCNB2 NEK9 NEK6 NEK7 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency OTC TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes PCNA PLK3 CDKN1A PRMT1 PLAGL1 NPM1 RGCC PLK2 CDK2 BTG2 CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 E2F4 CNOT9 CNOT11 E2F7 E2F8 RBL2 ZNF385A RBL1 SFN CCNB1 CDC25C CDKN1B AURKA ARID3A CDK1 BAX E2F1 CARM1 TFDP1 CCNE2 TFDP2 CCNE1 CPAP PCBP4 EP300 CNOT6L CCNA2 TP53 CCNA1 GADD45A CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CDC6 ORC5 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 UBE2W H2BC3 PEX14 H2BC1 USP7 HLA-B USP5 UBA1 RNF20 UBE2K CDC34 VCP UBE2J2 UBE2Q2 UBE2R2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA UBE2G1 UBE2G2 UBE2C CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS UBE2S WAC UBA52 PRKDC CTR9 RTF1 BCL10 UBE2Z TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 UBE2E3 PEX2 UBB UCHL3 UBC RPS27A UBE2T OTULIN UBA6 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP9X H2BC11 UBE2H UBE2B UBE2N RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 PAX5 ELF1 ELF2 CBFB BLK HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly APOA1 PRKACG A2M PRKACA PRKACB ABCA1 ZDHHC8 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 SOS1 PIK3R1 NRAS FGF20 MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 PPP2CA FGF18 PPP2CB FGF10 PTBP1 HNRNPM HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 BRAF UBB PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling SOS1 STAT5A STAT5B CBL PIK3R1 NRAS UBA52 CDKN1B GRAP2 PTPRJ CSK BCL2L11 FLT3 UBB PTPN11 UBC RPS27A AKT2 GRB10 HCK SYK HRAS LCK FYN SLA ABL2 SLA2 SOCS2 SOCS6 FOXO3 SH2B3 FLT3LG AKT1 GAB2 PIK3CA AKT3 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions HHIP BOC GAS1 SHH IHH DHH CDON PTCH1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle TRAK1 TRAK2 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol RXRA NCOA2 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 HSD3B7 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) LTC4S PTGR1 HPGD ALOX5AP ALOX12 ALOX5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 FCGR1BP PSMD13 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CD207 MRC2 ADRM1 PSME2 MRC1 PSMC5 PSMC6 SEM1 PSMC3 PSMB10 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 FCGR1A PSMD1 PSMB8 PSMB9 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing FURIN PCSK6 NGF PCSK5 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases ARSB ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD STS ARSA SUMF2 SUMF1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD GCLC GCLM PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PIP5K1C CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 DISEASE%REACTOME%R-HSA-1643685.19 Disease SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L SLC5A1 SLC5A2 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 RNF185 SLC26A3 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 EXOC1 GBF1 POMT2 CYP2U1 POMT1 CYP1B1 POMGNT1 B4GAT1 DAG1 LARGE1 FGFR2 OGG1 RAC1 VAV3 UBE2N VAV1 VAV2 CHST3 ACAT1 DCTN1 PTGES3 MAPK8 BCL2L11 DNAJA2 FKBP4 HSPA1B BAD IFNGR1 IFNGR2 B3GAT3 IKBKB SQSTM1 CYP27B1 MYD88 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FEN1 UBE2I SUMO1 UBE2D2 ELOB ELOC RBX1 VHL RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B TP53 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 ACTG1 PPP1CC PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DVL1 DVL2 DVL3 RPS27 ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CARS1 DYNLL1 RANGAP1 DYNLL2 EEF1G DCXR CHUK DYNC1I2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 TAOK1 TFG MPRIP FGFR1OP2 SND1 ZC3HAV1 EIF2AK3 NOX4 ATIC DUSP8 DUSP9 MRAS KDR FAM114A2 PORCN MCL1 QKI NF1 KIAA1549 DUSP10 ESRP1 BIRC6 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 AGTRAP AP3B1 SHOC2 AGGF1 NFKB2 CPSF6 SI TENT4A LCT SPRED3 CTDP1 SPRED2 ELL SPRED1 CCNT1 MYO18A SUPT4H1 ELOA LRRFIP1 NELFB KANK1 RRBP1 ETV6 WDCP NELFCD NELFA FAM131B GOLGA4 NELFE BIN2 STRN SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 LFNG JAG1 DLL1 SKP1 CUL1 NTRK3 NTF3 NEURL1B HES5 MIB2 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 RAF1 IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 JAK3 SIGMAR1 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 G6PC3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X RPS15 IGLV3-25 RPS14 IGLV3-27 IGKC RPS17 IGKV1-39 RPS15A RPS16 IGLV3-21 IGKV1-33 RPS19 RPS18 BRD4 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 RPS10 STAT2 RPS13 IGLC6 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 UBE2L6 RPS24 HERC5 RPS23 OGN NOTCH2 NOTCH3 NOTCH1 NOTCH4 HBEGF GCKR GCK HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E SFTPA2 RNF213 ATG7 SEC31A RPTOR CALR MLST8 EIF4E TSC2 MRC1 GRSF1 MTOR FKBP1A TLR6 AKT1S1 CYFIP1 NCKAP1 BRK1 PDIA3 S100A1 VPS36 CYBA VPS25 CBX1 SNF8 BCR CHMP1A LMO7 RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 NCKAP1L WASF1 PAK2 WASF2 CAV1 ERBIN BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 TGFB1 TGFBR1 TGFBR2 LMNB1 TIRAP SEC23A B3GALT6 B4GALT7 WIPF1 WIPF2 WIPF3 FCGR1A SEC24B SEC24A IQGAP1 MAP3K11 SEC24D SEC24C DUSP16 FGFR1 TMPRSS2 WASL SRPK2 GALNT1 AXL TCN2 CD320 RCC1 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 TPST2 TPST1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B MASP1 XRCC6 XRCC4 XRCC5 LIG4 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A ACAN RPL36AL LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 HDAC4 RPL27 HDAC2 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 AMER1 RPL35A RPL23A GSK3B CSNK1A1 RPL3L AXIN1 RPL27A RPL22L1 APC RPL26L1 OPN1SW ENO1 CDC73 SKIC8 CTR9 RTF1 ALDOB LEO1 PAF1 HHAT SHH PGK1 DHH MAP2K4 CGAS CREBBP IRAK4 SP1 KHK TLR10 TLR5 AREG NFE2L2 BCL2L1 PTPN6 MAPK9 IRAK2 MAP2K7 CAMK4 NTF4 NTRK2 BDNF TAB3 TGFA TAB2 NFKBIB FOXO3 ELK1 PTK2 IFNA5 EREG IFNA4 BTC IFNA7 MC2R EPGN IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 KCNJ11 ARIH1 ABCC8 IFNA13 ABCC9 IFNA14 ADCY9 IFNA16 IFNA17 ADCY4 BAG2 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 FGR GGT5 GSS OPLAH GCLC ITPR1 ITPR2 GGT1 ITPR3 GCLM NOS2 P2RX7 EML4 P2RX4 GNAS VPS33B CORO1A HGS RAB5A KPNB1 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 UPK1A EPCAM FDXR SLC6A19 SLC36A2 SLC6A14 FDX1 FDX2 SLC7A7 SLC7A9 DUSP6 DUSP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B CYP21A2 STT3A STT3B MAN1B1 ECHS1 RETREG1 KEAP1 H2AC17 AGK H2AC12 TRIM25 CFTR STAM CYP4F22 CYP19A1 H2AC25 H2AC21 WDR48 IFIH1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TBXAS1 KAT2B PIK3CD KAT2A RNF135 TAF9B SFTPC MAP3K7 GBE1 GYS2 H2AC1 CDC25A GYG2 EPM2A STAM2 PPP1R3C VCP NHLRC1 CLINT1 TNKS FOXO4 GALT CYP27A1 NLRP3 RIPK1 SUDS3 SMAD2 SMAD4 SMAD3 ESR1 NFKBIA SCAP MAVS MDM2 TAB1 RIGI PTEN ARRB1 ARRB2 TRAF2 MERTK H2BC18 TRAF3 TRAF6 BECN1 CYP7B1 NOD1 NOD2 TNKS2 TAF10 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 AQR CRNKL1 DPEP2 CDC40 DPEP1 DHX9 CSTF3 CYP11A1 CSTF2 PCBP1 PCBP2 CSTF1 CYP11B2 DHX38 SYMPK RBM10 HNRNPL HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 IRF4 PRPF6 BCL2A1 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CPSF4 CPSF1 FUS ALYREF CPSF3 CCR5 CPSF2 CXCR4 CWC15 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 SLC35D1 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC27A4 KIT RBPJ B4GALT1 TXNIP SFN EZH2 CLDN1 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 PMS2 RICTOR MBD3 STAT1 GATAD2B GATAD2A CCNT2 CDC25C MSH2 KMT2D FOXO6 FOXO1 MED30 MED31 G6PC1 NFKB1 SFTPB SFTA3 SFTPA1 FASLG ITGA4 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A CCNK MUC5AC MUC3B CCNC ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 SH3GL3 EPS15 SH3GL2 SH3GL1 YES1 EEF2 CTSL SYVN1 RELA FZD8 ARPC1B ARPC1A NPM1 ITCH KLC1 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH ACTR3 ACTR2 NR3C1 TRAK1 KIF5B IRAK1 NCKIPSD ACY1 IL6 TAF4B YWHAE PRR5 DPY30 CHD4 PPM1K YWHAQ AUH IVD YWHAG HIBCH C4A YWHAH TBP EED GALM TAF9 TAF1L MTA2 TAF15 TAF12 TAF13 TAF11 SOD2 REST TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 MAML2 MAML1 DNAJC3 JUNB MED1 GALK1 MED8 GALE MED4 MED6 MED7 MAML3 MAPKAP1 NEDD4L PRDX2 PRDX1 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 PLK2 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 CD19 V2-8 V1-20 ASH2L V1-9 TAF7L V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QA C1S V4-6 V4-2 V4-1 ISCU SNAP25 SYT1 MSH3 PTPN12 NRBP1 TLR8 PAH KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ABL1 GNS CDK8 CDK5 WDR5 PYCARD CLEC5A GYG1 HDAC5 RAB5B RAB5C HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 RBBP5 RBBP7 TXNRD1 PML PGM1 HDAC10 TTR HDAC11 FCGR2A TWIST1 TXN PARP1 BST2 PRMT1 GP1BA HBB CD33 MLH1 TJP1 GAA CDK5R1 ESR2 NR4A1 CASP1 CD300A THBS1 ERBB2 HES1 DDX3X POMC PHB1 ARAF PEBP1 CSK JAK2 MARK3 HGSNAT FGB DYNLT1 BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 GALNS SLC9A6 SLC9A9 HCK SYK LCK UGT1A4 FYN F9 F10 GGCX PROS1 F2 GAS6 UGT1A1 BCKDK BCKDHA BCKDHB DBT DLD CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 CUBN AMN APOA1 SAR1B AP2S1 AP2B1 P4HB PRF1 ICOS STAT5A IL10RA ZC3HC1 CD3G BTRC ADAMTS13 MTA1 MTA3 FCGR3A MYH2 MYO10 MYO1C APRT PNP HPRT1 ADA PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX FZD5 FZD4 FZD6 PIM1 GBP2 GBP4 IKBKE IRF7 GP1BB F12 F11 GP5 GP9 KLKB1 BAG4 RAN SLC20A2 NEK2 WNT3A LRP5 KREMEN1 TUBB KREMEN2 DKK1 DKK2 LRP6 DKK4 AKAP9 ABCA4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 SUGT1 IGF1R CALM3 CALM2 CEP43 KDM7A ATP1B3 ATP1B2 ATP1B1 RBP4 RDH12 OPN1LW RBP1 NAPEPLD LRAT STRA6 FXYD4 MMAB FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 MTRR ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ANO10 CLCN6 SUN2 CBLIF MMACHC MMADHC NRG3 NRG4 NRG2 NTHL1 NEIL3 NEIL1 PIK3AP1 SIKE1 CSF2RB CSF2RA CD36 STAT5B GRB2 ARID4B CTBP2 CTBP1 SAP30 DNMT1 NCL CEBPD PDGFRB DNMT3B DNMT3A SAP30L RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 PARP9 IL17F IL17A PARP14 PARP8 GEMIN2 TUFM GEMIN4 CRK GEMIN5 GEMIN6 FMO3 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 FADD P4HA3 CD14 GSDMD DNAJC10 NMT1 GSDME C1QBP MAT1A RIPK3 IL18 IL1A IL1B TLR4 BCAP31 AHCY FNTA TICAM1 CHMP4C CHMP4B CHMP4A LY96 MLKL MAOA CHMP2B CHMP2A TRADD HMGB1 CASP8 CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 PAPSS2 PAPSS1 SDC4 SDC2 SDC3 SGSH NAGLU GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 SLC5A5 LYN PIK3CG PIK3R6 PIK3R5 BTK ARF1 NPLOC4 RPLP0 JAK1 IL10 MSN TALDO1 TYK2 PPIA ALK AHCYL1 LMNA KPNA2 MMAA MMUT MCCC2 BTD PC PCCA HLCS MCCC1 PCCB SPCS3 SPCS2 SPCS1 SEC11A SEC11C FOXM1 GNAZ CD163 RHBDF2 ADORA2B JAG2 ADAM17 RDH5 RLBP1 CYFIP2 GJA1 ZMYM2 FGFR3 GYS1 TPM4 TPM3 RNF43 KLB FLT3 IRS1 IRS2 EIF4E3 PIK3CB PPM1B FGF1 FGF2 FGF3 EIF4G3 FGF4 EIF4G2 FGF6 NCK1 FGF7 FGF9 AKT2 HRAS WASF3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 TLR9 PIK3C3 SOS1 RAC2 SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 NRAS FGF20 PPFIBP1 ATP6V1H MAPK1 FGF23 FGF22 ELMO2 MAPK3 PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 UNC93B1 TLR3 ABCA3 CAMK2B CAMK2D SRC CAMK2A NRG1 MTR ZAP70 CALM1 DOCK2 CAMK2G ANAPC15 DOCK1 ANAPC16 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CCNB1 CDC23 TRAT1 UBE2S RPS6KB2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 CYP11B1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 APP RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 HGF RAD9B RHNO1 ATR RAD9A CLIP1 SLC25A15 CPS1 ARG1 ASL NAGS KDELR1 SERPING1 ASS1 GCC2 NMRAL1 OTC PDGFB CLU HSPA5 CTSG COG1 TLR1 S100A9 S100A8 LTF TLR2 F8 CD9 S1PR1 GOLGA2 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST PRIM2 CUX1 CD4 PRIM1 POLA1 POLA2 ACACA TRIP11 PDGFRA GTF2A1 CHSY1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN TCF7L2 CDKN1A HDAC1 CDKN2A CDC25B CCND1 SIN3A CDK2 CTNNB1 MET CEBPB TNRC6C MOV10 ACOT2 STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 GRPEL1 YWHAB ELAVL1 PSMD8 HMOX1 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 IDH1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 PEX19 SRD5A3 C3 FURIN SLC67A1 CPSF7 ROCK1 ROCK2 CUL3 SRRM1 VIM HNRNPC RBMX AP1G1 ZBP1 AP1S2 AP1S1 AP1S3 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 HLA-A CD8B PACS1 IDUA ELMO1 NCAN CD28 HEXB OPN1MW HEXA BGN PALS1 DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB UVRAG MAP1LC3B TRIM27 HSP90AA1 EGF CBL EGFR CYP17A1 CDC37 PLCG1 CDKN1C RB1 CDKN1B CCND3 FZR1 FNTB CCND2 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 NMT2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX LIG1 MSH6 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 SFPQ IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 TAL1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ABCA1 ABCG8 ABCG5 NCOR2 NCOR1 TBL1XR1 DPAGT1 ST6GALNAC2 MPI HK1 GNAI3 GNAI1 GNAI2 ALG8 ST6GAL1 ALG9 ALG6 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 DHDDS DPM1 DPM2 DPM3 RFT1 ST6GALNAC3 ST6GALNAC4 SLC24A1 GNE NEU1 ST3GAL4 SLC17A5 ST3GAL1 AVP ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 SLC4A1 PMM2 ABCA12 SLC4A4 BSG GFPT1 SLC12A6 DOLK SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling TYK2 CANX IL6ST STAT4 JAK2 IL27RA EBI3 STAT3 IL12A JAK1 IL12RB2 STAT1 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions SLCO4A1 SLCO1A2 SLCO2B1 SLCO4C1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 AVP SLCO2A1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling JUN RELA RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 VAV3 PPP3CA PPP3CB PRKCQ PPP3R1 VAV1 UBE2N VAV2 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 NFATC2 V1-11 V1-16 V1-13 MAPK8 IKBKB V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 PSMD14 NFATC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 PSMC3 AHCYL1 PSMC4 PSMC1 PSMC2 PAK2 RASGRP4 MAP3K7 CARD11 MALT1 NFKBIA TAB1 TEC TRAF6 PLCG1 PIK3CB HRAS PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 NFKB1 NRAS MAPK1 CHUK FCER1G MAPK3 CALM1 UBE2D1 FCER1A LAT2 BCL10 MS4A2 TXK MAP2K4 FBXW11 MAPK9 SYK MAP2K7 SEM1 MAP3K1 FYN MAPK10 TAB3 SKP1 TAB2 FOS CUL1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NEDD4L TGIF1 UBE2D1 TGIF2 TRIM33 PARP1 HDAC1 UBA52 MAPK1 SKIL MAPK3 UBB ATP1B4 SKI UBC SMAD2 NCOR2 RPS27A SMAD4 SMAD3 NCOR1 SMURF2 SMAD7 SNW1 RNF111 WWTR1 PPM1A UBE2D3 USP9X RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF RUNX1 CCND1 BRD2 RUNX3 EP300 KRAS HDAC4 CBFB TGFB1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response MYH9 CD163 RHBDF2 FURIN ADAM17 IL10 MAPK14 PLK2 IL6 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle TFRC KIF14 KIDINS220 VANGL1 MUC13 PIK3R2 ARHGAP5 TMEM59 PIK3R1 ARHGAP35 TXNL1 ALDH3A2 PKP4 RASAL2 STIP1 PLXNA1 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 STMN2 EPSTI1 PTPN13 RND1 PLEKHG5 FRS2 FAM135A GRB7 VANGL2 FLOT2 DSP CAV1 RRAS2 CCDC88A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere H2BC9 ACD H2AZ2 TINF2 POLR2A H4C9 TERF1 POLR2B H2BC8 TERF2 POLR2C H2BC5 POLR2D H2BC3 POLR2E H3-4 POLR2F H2BC1 POLR2G POT1 POLR2H TERF2IP POLR2I POLR2J H2AC20 POLR2K POLR2L DAXX ATRX H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle CUL3 PLIN3 RAB9A RAB9B HGS VHL CCNE1 RHOBTB3 LRRC41 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLRMT POLG2 RNASEH1 TOP3A POLG TWNK MGME1 EXOG SSBP1 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance ALDOB COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 COL17A1 ITGB4 COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 PLEC COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 LOX COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 CTSS PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB LAMB3 P4HA1 LAMA3 P4HA2 P4HA3 LAMC2 COL1A1 COL1A2 ADAMTS14 MMP9 P3H2 P3H1 P3H3 PXDN MMP3 SERPINH1 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis GGPS1 LSS SQLE IDI2 ACAT2 MVD IDI1 MVK PMVK FDFT1 FDPS PLPP6 HMGCS1 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome TAF7L CCNT2 TAF4B ELOB ELOC RNMT CCNH POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L RNGTT GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 SUPT5H GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 TAF10 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 CD8B ATP6V1H TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion TRIT1 YRDC TRMU TRMT61B OSGEPL1 GTPBP3 TRMT10C MTO1 PRORP HSD17B10 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 POMT2 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs RBM8A ISL1 ETF1 GSPT2 GSPT1 UPF3A USP33 UPF2 LDB1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH HOXA2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 ZSWIM8 RPL34 MSI1 RPL10L RPL8 RPL10A RPL6 RPL7 LHX3 RPL7A RPL18A RPL36AL LHX2 RPL36 LHX4 RPLP2 RPL35 LHX9 RPL38 RPL37 COL4A5 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A ROBO2 RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CASC3 PSMB4 PSMB5 UBB PSMB2 PSMB3 NCBP1 SLIT1 UBC NCBP2 PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 BTK CFL1 ACTB MYO5A SYK PAK1 NCKAP1L WASF1 PTK2 WASF2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion PPIA CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA RELA XRCC6 XRCC5 NFKB1 DHX9 CTNNB1 CHUK IKBKB RIPK1 MYD88 ZBP1 TLR3 TREX1 DDX41 DTX4 TBK1 IRF3 NFKBIA STING1 NLRP4 TRIM32 TRIM21 TRIM56 IRF7 NLRC3 IFI16 CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F UBA52 POLR3G PRKDC DHX36 POLR3H POLR2K POLR2L POLR3K MRE11 NFKB2 RIPK3 NKIRAS1 LRRFIP1 NKIRAS2 IKBKG UBB CGAS AIM2 CREBBP UBC TICAM1 RPS27A EP300 STAT6 NFKBIB POLR1C POLR1D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways RELA MAP3K7 NFKB1 HSP90AB1 ITCH PANX1 CHUK MAP2K6 NLRP3 IKBKB IRAK1 CARD9 TAB1 TXNIP HMOX1 TNFAIP3 MAPK12 MAPK13 CASP1 CASP2 P2RX7 PYCARD TRAF6 BIRC2 BIRC3 NLRC4 CYLD NFKB2 NOD1 NOD2 IKBKG NLRP1 RIPK2 AIM2 BCL2 UBE2V1 BCL2L1 AAMP MAPK14 IRAK2 MAPK11 APP MEFV PSTPIP1 TAB3 TAB2 SUGT1 CASP8 TXN CASP4 CASP9 UBE2N BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport KIF28P KDELR1 KDELR3 KIF5C KIF21A KIF21B KIFAP3 KLC1 KLC4 KLC3 KLC2 RINT1 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 KIF3B SEC22B KIF3C RAB6B KIF5B KIF5A KIF18B KIF4B KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 BICD2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 PAFAH1B3 ARF5 NAPA GBF1 NAPB NBAS RAB6A RAB1A STX18 RAB1B NAPG GALNT1 BNIP1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 GALNT2 ARCN1 ZW10 KIF26A KIF26B RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 ACTR1A ARF1 DCTN2 CAPZA1 DCTN3 RACGAP1 ARFGAP1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 TUBB2B TUBB2A TCP1 CCT6B TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 UBC TICAM1 RPS27A TLR3 TBK1 IRF3 TRAF3 OPTN UBA52 IKBKE IRF7 TANK UBB ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP CHTF8 PRIM2 PRIM1 POLA1 DSCC1 POLA2 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 CHTF18 RFC2 RFC1 STN1 TEN1 CTC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis MAPK1 CTSG TRIM27 SFPQ RNF213 GSK3A MAPK3 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CREBBP BHLHE40 RBM4 DBP TFEB CRY2 CRY1 CIPC PER2 PER1 RORC PER3 RORA NR1D1 BMAL1 CRTC1 KMT2A SIK1 CLOCK NPAS2 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R4 GNG13 KCNJ2 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 SCNN1G SCNN1D SCNN1B SCNN1A TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 OTOP1 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis CHST15 CSPG4 CHST3 CHPF NCAN CHSY1 CHST11 BGN CHST12 CHSY3 DCN CHST13 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 UST CSPG5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs MON1A TRAPPC6A MON1B DENND1C TRAPPC6B DENND1B GDI1 DENND1A ULK1 RAB8B DENND2D TRAPPC10 RAB14 DENND2C DENND2B DENND2A RAB3IL1 GDI2 RAB7B DENND3 RAB21 ALS2CL RAB27B CHML RAB12 RAB13 TRAPPC4 CHM RAB9A RAB6B RAB9B RAB39A YWHAE AKT1 ALS2 RAB3A RAB31 RAB5B RAB5C RAB3IP RAB6A RAB1A RAB1B TRAPPC1 RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 GAPVD1 RAB7A RIC1 RAB32 RAB35 RGP1 RAB27A RAB38 AKT2 DENND6B RIN3 RAB3GAP2 RAB8A TRAPPC2L DENND6A RAB10 RIN1 RIN2 RAB3GAP1 RAB18 TRAPPC2 TRAPPC3 ANKRD27 DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B AKT3 TRAPPC8 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling TNFSF10 TNFRSF10B TNFRSF10A CASP10 CASP8 TNFRSF10D FADD CFLAR INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling TYK2 IL6ST JAK2 STAT3 CBL JAK1 SOCS3 IL6R STAT1 PTPN11 IL6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network SCOC SYS1 GCC2 GCC1 RAB43 GOLGA1 ARFIP2 RHOBTB3 COG8 COG7 COG6 NSF COG5 COG4 COG3 COG2 COG1 ARL1 VTI1A PLIN3 RAB9A RAB6B RAB9B RABEPK M6PR NAA30 IGF2R NAA35 NAA38 VAMP4 NAPA NAPB TGOLN2 TMF1 STX16 RAB6A NAPG STX10 ARFRP1 VPS51 GOLGA4 VPS53 VPS52 STX6 VPS54 VAMP3 RIC1 RGP1 USP6NL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY2 LEFTY1 SMAD4 SMAD3 CRIPTO3 FURIN DAND5 PCSK6 CFC1 CER1 NODAL GDF1 CRIPTO MAPK1 FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C FOXO3 MAPK3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MT1G MT1H MT1X MT4 MT1B MT3 MTF1 MT1E CSRP1 SNCB MT2A MT1A MT1M MT1F DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines SAT1 PAOX PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 POLE FEN1 RFC2 RFC1 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 APEX1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis ARV1 GGPS1 CYP51A1 LSS SREBF2 SQLE DHCR7 IDI2 ACAT2 MVD EBP LBR HSD17B7 DHCR24 PLPP6 NSDHL MSMO1 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC6A20 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling IFNA2 ADAR IRF1 IRF2 IFNA8 XAF1 IFNA13 HLA-H IFNA14 IFNA16 IFNA17 HLA-B BST2 HLA-C HLA-F HLA-G HLA-E OAS2 IFITM3 IFITM2 IFNA10 IFIT5 IFI35 IFNA21 IFIT3 IFNB1 IFIT2 EIF2AK2 ISG15 RSAD2 IFI27 STAT1 SOCS1 PTPN1 IP6K2 PTPN11 EGR1 IFI6 IFITM1 ISG20 IRF8 IRF6 IRF3 IRF9 IFNAR1 SAMHD1 HLA-A GBP2 IRF7 PSMB8 ABCE1 KPNA1 UBA52 OASL OAS1 OAS3 RNASEL JAK1 KPNB1 USP18 UBB IFIT1 UBC TYK2 MX2 RPS27A MX1 STAT2 SOCS3 PTPN6 IRF4 IRF5 IFNA5 IFNA4 IFNA7 IFNA6 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ACE2 FURIN ANO1 TMPRSS2 ANO10 ANO8 ANO9 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib ERBIN HSP90AA1 ERBB2 CDC37 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT SLC24A1 RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL3 PSMA7 PSMB6 PSMB7 HECW1 KLHL12 PSMB4 PSMB5 DACT1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 DVL1 PSMC4 PSMD8 DVL2 PSMC1 PSMD6 DVL3 PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis TYRP1 SLC45A2 TYR OCA2 DCT SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants FLT3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN APH1A FGD1 PSENEN FGD2 GNA13 NCSTN FGD3 APH1B PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ITGB3BP ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 SQSTM1 YWHAE CASP2 TRAF6 UBA52 BEX3 UBB UBC RPS27A TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 CASP3 TIAM2 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G2D PLA2G2E PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 PLAAT3 PLA2G2A LPCAT1 PLA2G4A PNPLA8 PLA2G4F PLA2G12A TMEM86B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 PLB1 LPCAT3 PLBD1 LPCAT2 PLA2G2F MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation YAP1 GLI3 HEY1 HES1 BGLAP HEY2 ABL1 RB1 WWTR1 SRC YES1 MAF HDAC3 COL1A1 SATB2 MAPK1 HDAC6 SP7 UCMA MAPK3 CBFB ZNF521 AR CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins EPB41L3 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 EPB41L1 STX1A SHARPIN SYT9 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 CASK NRXN2 GRIN2A LIN7A DLG2 LIN7C DLG3 LIN7B DLG4 PDLIM5 NLGN4Y NLGN4X SYT10 SYT12 APBA1 SYT1 DBNL GRM1 GRM5 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 FGF18 FGF1 FGF2 FGF4 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs CDC42 RAC1 IQGAP1 IQGAP2 IQGAP3 CTNNB1 CDH1 MEN1 CALM1 CLIP1 CTNNA1 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling CLTC CLTB TIAM1 CLTA AP2A1 AP2A2 ARHGEF7 ARPC1B NGEF ARPC1A AP2M1 RHOA KALRN APH1A PSENEN ROCK1 NCSTN ROCK2 APH1B PSEN2 CLTCL1 ARPC4 ADAM10 ARPC5 PSEN1 ARPC2 ARPC3 DNM1 ACTR3 ACTR2 ARHGEF28 SDC2 CDC42 AP2S1 AP2B1 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 GRIN2B EPHA1 EPHA3 GRIN1 MYL9 EPHA10 EPHB6 EFNB2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 EFNA5 EFNA4 CFL1 GIT1 EFNA1 EFNA3 WASL EFNA2 ACTG1 MMP9 ACTB MMP2 NCK2 EPHA2 ITSN1 RASA1 SDCBP YES1 PAK1 PAK3 LIMK2 RAC1 HRAS LIMK1 MYL12B FYN VAV3 MYL6 MYH9 MYL12A MYH14 MYH11 MYH10 PAK2 PTK2 VAV2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE5A MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 SLC35A1 CHST10 DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A4 FKRP CRPPA POMGNT1 B4GAT1 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs ALK HIP1 PRKAR1A CLTC STRN PPM1B BIRC6 NPM1 EML4 FN1 EIF2AK3 BCL11A SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) TIAM1 SOS1 FRS3 CDK5 NTF3 PIK3R1 NRAS PLCG1 SRC DOCK3 RAC1 HRAS GRIN2B NTF4 NTRK2 BDNF GAB1 FRS2 PIK3CA CDK5R1 PTPN11 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CB JAK2 PIK3CD LYN GAB1 PIK3R1 PIK3CG PIK3CA PIK3R5 EPO EPOR IRS2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS HRAS RAPGEF1 SOS1 JAK2 SHC1 LYN NRAS CRKL EPO VAV1 EPOR IRS2 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases UBC GYG1 RPS27A SLC37A4 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 EPM2A PPP1R3C NHLRC1 GAA G6PC3 UBB GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism GCKR GCK PPP2R5D G6PC1 PC PRKACG PRKACA PRKACB PCK1 PPP2CA PPP2CB SLC37A4 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK2 PGK1 SLC37A1 NUP37 PGK2 G6PC2 PFKL G6PC3 FBP1 GNPDA1 FBP2 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP CITED2 ARNT CA9 HIGD1A VEGFA EPAS1 EP300 HIF1A EPO ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MRAS PPP2R5B PPP2R5A PPP2R5D PPP2R5C NRAS PHB1 MAP3K11 ARAF SHOC2 RAF1 JAK2 MARK3 BRAP KSR1 PPP1CB PPP1CC BRAF PPP2R1B PPP2R1A PPP2CA PPP2CB CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS MAP2K1 MAP2K2 CALM1 CAMK2G PPP2R5E ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism CYP4B1 FAAH DPEP2 DPEP1 ALOX15 LTA4H PTGES3 PTGDS CYP4F3 CYP4F8 CYP2J2 PRXL2B PLA2G4A GGT5 PTGES PTGR1 CYP4A22 PTGR2 GGT1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 ALOX15B LTC4S PON3 HPGD PON2 PON1 EPHX2 GPX2 HPGDS ALOX5AP MAPKAPK2 CBR1 CYP4F22 CYP2C9 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 CYP4F11 SLC27A1 TBXAS1 PTGES2 ALOX12 GPX1 GPX4 CYP8B1 FAAH2 AKR1C3 AWAT1 ALOXE3 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 MAPK1 MAPK8 IFNB1 MAP3K5 MAP2K6 MINK1 MAPK3 TNRC6C TNIK MOV10 BMI1 AGO3 CBX6 AGO4 RING1 MAP4K4 AGO1 MDM2 TNRC6A MDM4 TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 EED CDKN2D CDKN2C MAPKAPK2 UBA52 CDKN2B E2F1 RBBP4 E2F2 MAPKAPK5 E2F3 EZH2 CDK6 TFDP1 RBBP7 TFDP2 CDK4 H2AX MAP2K3 UBB MAP2K4 H2AB1 MAPKAPK3 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 MAPK9 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 H2BC17 MAP2K7 H2BC12 H2BC13 MAPK10 H2BC14 H2AJ H2BC15 FOS TP53 H2BC11 TXN KDM6B H3C15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors APOA1 SSC5D S100A9 PRDX1 CD5L APOB CD36 SAA1 HMGB1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin TPGS1 TPGS2 TUBB8 AGBL5 AGBL4 AGBL1 AGBL3 TUBA1C AGBL2 TUBA1B TUBB8B TUBA1A LRRC49 VASH2 VASH1 TUBB2B TUBB2A TTLL7 TTLL6 TTLL5 TTL TTLL4 TUBB6 TTLL3 TUBB3 TTLL2 TUBA3E TUBB1 TTLL1 SVBP TTLL9 TTLL8 TUBA3D AGTPBP1 TUBA3C TTLL10 NICN1 TTLL13 TTLL11 TTLL12 TUBB4B TUBB4A DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions CLEC5A SOS1 SIGLEC14 PIK3R2 PIK3R1 HLA-B KLRK1 HLA-C KIR3DS1 NRAS PLCG1 BTK HLA-E GRAP2 NCR2 KIR2DS2 SIRPB1 KIR2DS4 KIR2DS5 CD300LB TREM1 SIGLEC16 SIGLEC15 CD300E LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 PRIM2 PRIM1 POLA1 H2AX POLA2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L POLE H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 CDC45 KPNA6 MCM10 DBF4 RPA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors STAB1 APOB SPARC STAB2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCB6 ABCB4 SEL1L KCNJ11 ABCC8 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 ABCD4 VCP ABCC2 ABCA1 ABCG8 ABCC6 ABCG5 LMBRD1 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 ABCA3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ABCA12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora EPM2A UBC GYG1 RPS27A PPP1R3C NHLRC1 UBA52 GYS1 UBB THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism SDS SDSL RIDA P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway HLA-H CTSV B2M HLA-B CTSL HLA-C CTSS HLA-A HLA-F HLA-G HLA-E LNPEP GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TOPORS SUMO2 UBE2I SUMO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling CBL UBA52 FGF20 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF7 FGF9 MKNK1 SPRY2 FRS2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence RPS6KA1 JUN CXCL8 RELA HMGA2 H1-1 H1-0 H1-3 LMNB1 IFNB1 CABIN1 H1-2 MAP2K6 H1-5 H1-4 HIRA UBN1 EP400 ASF1A MDM2 MDM4 IL6 EED CDKN2D CDKN2C RB1 HMGA1 CDKN1B FZR1 E2F1 IGFBP7 RBBP4 E2F2 MAPKAPK5 E2F3 CDK6 IL1A TFDP1 RBBP7 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TXN KDM6B H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 VENTX TERF2 H2BC8 H2BC5 H2BC3 MAPK7 STAT3 H3-4 H2BC1 NFKB1 CDKN1A POT1 TERF2IP H2AC20 CDKN2A MAPK1 CDK2 MAPK8 MAP3K5 CEBPB MINK1 MAPK3 ETS1 ETS2 EHMT2 EHMT1 ERF TNRC6C TNIK MOV10 ID1 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 MAP4K4 TNRC6A TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 MAPKAPK2 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 EZH2 KAT5 NBN MAP2K3 UBB MAP2K4 MAPKAPK3 UBC SP1 RPS27A MAPK9 MAPK14 MAPK11 MAP2K7 RAD50 MAPK10 TP53 FOS CCNA2 ATM CCNA1 RPS6KA3 RPS6KA2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease HRAS SOS1 FGFR4 GAB1 FRS2 PIK3R1 NRAS PIK3CA PLCG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 PRDX1 RELA MAFG PGD NFKB1 ABCG2 NQO1 CDKN2A GSTA3 GSTA1 SRXN1 CHD6 CCL2 ABCF2 PRKAA2 SOD3 G6PD SQSTM1 ATF4 GCLC TKT ABCC3 MYC ABCC1 GCLM PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B IDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF PSMA2 UBA52 PSMD12 PSMD11 ME1 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 BACH1 UBB TXNRD1 PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 PSMB1 BCL2 PDGFA RPS27A MAFK SLC7A11 AREG NFE2L2 BCL2L1 EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TXN NOTCH1 CUL1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane MTMR3 MTMR8 MTMR9 RAB14 PIK3R2 MTMR6 PIK3R1 PIP5K1A PIP5K1B MTMR14 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B INPP5J INPP5K PI4K2A PTEN MTMR1 PIP5K1C INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RAB4A RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 INPPL1 RUFY1 PIK3CA PIK3R3 SBF2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate CHIA AMY2A AMY1A MGAM AMY2B TREH AMY1B SI AMY1C LCT CHIT1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) GP5 SERPINA5 GP9 SERPING1 KLKB1 CD177 THBD GP1BA KNG1 C1QBP FGB F3 FGA VWF FGG PF4 F2R A2M PRCP TFPI F13B PRTN3 SERPINC1 F7 F13A1 F9 PROC F10 SERPIND1 F5 PROS1 PF4V1 F8 F2 SERPINE2 GP1BB F12 F11 PROCR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination SRSF6 CLP1 SRSF7 MAGOH ZNF473 SNRPD3 SNRPB SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF7 CPSF1 ALYREF DDX39B CPSF3 CSTF3 CSTF2 CPSF2 SRRM1 CSTF1 DHX38 SYMPK UPF3B MAGOHB RNPS1 PCF11 WDR33 LUZP4 POLDIP3 SRSF1 SLU7 CSTF2T U2AF1 FYTTD1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SRSF11 NUDT21 CASC3 PAPOLA LSM10 NCBP1 LSM11 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SNRPG SRSF2 SRSF3 SNRPE EIF4A3 SRSF4 SNRPF SRSF5 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 SLIT1 SLIT3 DCC NTN1 NELL2 SLIT2 ROBO1 SRC DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling AIP ARNT2 PTGES3 ARNT AHRR HSP90AB1 AHR STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 RAF1 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 TRPM1 SRI TRPM2 TRPM7 TRPM8 TRPM5 WNK1 TRPM6 TRPM3 WNK2 TRPM4 WNK3 TRPC7 TRPC5 MCOLN3 TRPC6 RYR1 TRPA1 RYR2 TRPC3 RYR3 TRPC4 UNC80 TRPC1 TRPV2 TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 STOM NEDD4L SGK1 CALM1 UBA52 WWP1 UBB UBC RPS27A OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System SEL1L ERLIN1 ERLIN2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 UBE2V2 RAC1 VAV3 COPS5 UBE2N VAV1 VAV2 ADAR SOS2 DCTN6 DCTN5 DCTN1 DCTN4 HSPA1L HSPA2 CAPZA3 MAPK8 BCL2L11 CAPZA2 ACTR10 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 UBE2I SUMO1 UBE2D2 UBE2D3 ELOB ELOC RBX1 EPAS1 CUL2 HIF1A VHL POLR2E POLR2F POLR2H POLR2K POLR2L KRT1 ACTB FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B TP53 FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 SPHK1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 TCP1 BTNL2 XDH MT2A CCT8 TUBB4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 DSC1 NUP50 NUP35 NUP54 NUP37 ACTG1 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DSN1 DIAPH1 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 RHOA KIF2A BIRC5 EVL KIF2C KIF2B CHUK DYNC1I2 IP6K2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE EIF2AK3 CENPS CRCP MCL1 POLR3GL POLR3A POLR3B VEGFA POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IL22 NFKB2 CD274 IL2RG LRRFIP1 FCN2 BIN2 FCN3 CRP COLEC10 SKP1 CUL1 SLC15A4 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 CA1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 PRKRA IGKV4-1 TARBP2 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM LAMA5 SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 BRWD1 IGLC3 BLNK IGLC1 VTN IGLC2 JAK3 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 BRD4 IGLC7 IGHV3-53 IGKV5-2 STAT2 IGLC6 IGKV1-5 IMPDH1 IMPDH2 PDCD1 LIMK1 EEF1A1 MYH9 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 IL23R FBXO9 IL13RA2 IL13RA1 HLA-H IL4R WSB1 FBXO2 IL23A HLA-B FSCN1 HLA-C NDN ATG14 LIF NANOG HLA-F IGHE HLA-G HSP90AB1 HLA-E OPRD1 OSM RNF126 CDC34 BATF HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 PRKAA1 ATG7 PRKAA2 CAB39 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 CD207 CALR FBXL4 MLST8 DZIP3 RNF220 EIF4E DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 MTOR LRRC41 VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 LAMTOR2 UBE2G2 LAMTOR1 PSMB8 PSMB9 LAMTOR3 KLHL9 SPSB2 CYFIP1 NCKAP1 SPSB1 KBTBD6 NCF1 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 BRK1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z STBD1 FBXO22 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 RAPGEF1 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 RAB7A TRAIP RNF41 KLHL42 UBE2V1 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 ABL2 FBXO40 NCKAP1L BTBD1 LONRF1 WASF1 UBE2F PAK2 RAG2 UBE2H RAG1 KLHL25 WASF2 UBE2B IL32 ZBTB16 RASGRP4 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 BAIAP2 FBXO31 KLHL20 UBE2W UBOX5 ABI2 UBE2U RNF182 UBA3 ABI1 UBE2O TPP2 UBA1 BLMH UBE2K TGFB1 UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 LMNB1 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP IL1RL2 PJA1 IL36A TAPBP IL36B TRAF7 IL36G UBE2R2 IL36RN SEC22B IL1F10 THOP1 TRIM50 SEC23A MGRN1 ASB13 ASB14 ASB11 CLEC10A RNF6 CLEC4A ASB12 WIPF1 CLEC4E RNF7 WIPF2 CLEC6A ASB17 WIPF3 DHX58 RNF4 RNF125 TAX1BP1 ASB18 RNF216 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 TNFRSF6B HECTD1 EDA HECTD2 TNFRSF13B HECTD3 TNFRSF11B ASB10 EDA2R TNFSF13B FCGR1A TNFRSF17 SEC24B TNFRSF8 TRIM41 ARHGAP45 TNFSF11 SEC24A TNFRSF4 ERAP2 EDARADD RNF25 TNFSF18 FBXL19 IQGAP1 TNFSF14 PLD1 ERAP1 TNFSF15 FBXL15 IQGAP2 FBXL16 CD70 TNFRSF9 FBXL13 EDAR FBXL14 FBXL12 TNFSF6 TRIM39 TNFSF4 LTA ASB8 JUP CD27 ASB9 LNX1 TNFSF9 TNFRSF25 ASB6 ASB7 TNFSF8 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 ARHGAP9 SEC24C ASB1 WASL PTPRZ1 PAG1 WAS STOM PAK3 MYO9B COLEC12 MAP2K1 COLEC11 HSP90B1 ITGAV NCAM1 FTH1 MASP1 FTL ITGB5 XRCC6 XRCC5 PDCD1LG2 B3GNT3 SPOP ITGAX PIAS1 SUZ12 GSK3B GPI ABCE1 HK3 KLRK1 PGAM1 KIR3DS1 PRKDC DHX36 FCER1A LAT2 BCL10 NCR2 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E LPO NKIRAS2 MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 BCL2 TLR10 TLR5 ALPK1 LRRC14 NLRX1 NFE2L2 BCL2L1 PELI3 BTLA PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 JUN IFNA2 IFNA8 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 OAS2 IFNA10 IFNA21 IFNB1 PTPN22 EIF2AK2 ISG15 CD209 NOS1 APEH FGR STIM1 ORAI2 PECAM1 ORAI1 ITPR1 ITPR2 ITPR3 APOB NOS2 NOS3 MME P2RX7 P2RX1 IST1 KPNB1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 RPN2 TUSC3 PRKCSH RPN1 MAGT1 LTA4H ATF6 GOLGA7 OST4 LGMN DDOST LPCAT1 TMEM258 DAD1 OSTC CANX STT3A STT3B PTGS2 ALOX5 KEAP1 TRIM25 RNF123 GATA3 TNFRSF12A TNFSF12 SIAH2 TNFRSF13C TNFRSF11A CD40LG CYLD LTBR LTB IFIH1 TRIM4 IKBKG TOMM70 RIPK2 OSBPL1A PIK3CD PRKN RNF135 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 SMAD3 CXADR SMURF2 SMAD7 NFKBIA MAVS TAB1 RIGI PTEN TNFAIP3 CD74 SLC44A2 GLIPR1 JAML CD99 TRAF2 TRAF3 TRAF6 BIRC2 BIRC3 USP14 BECN1 NOD1 NOD2 USP18 ORMDL3 PTGES2 TNIP2 INPPL1 EIF4A3 ALOX15 PLD4 PLD3 DHX9 ALDH3B1 PCBP2 DEGS1 HNRNPF HNRNPA2B1 ILF3 MYO5A RAB27A THOC5 CEACAM1 ZEB1 IRF4 PPIE CCR5 FPR2 YBX1 SNRPA1 ANXA1 PTAFR MMP3 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA IRAK3 EBI3 MEF2C IFNLR1 B4GALT1 IL20 IL25 IL26 IL24 IL27 IL11 IL19 IL16 IL17RE OSMR IL17RB TXNIP IL31 IL17C IL11RA IL7 IL7R IFNL2 IFNL1 IFNL3 SFN COL1A2 EZH2 KCNAB2 CASP10 FAAP100 FAAP24 FAAP20 FANCM CTLA4 FANCL FANCA FANCB FANCE FANCG FANCF RICTOR STAT1 RORC RORA PDE12 OASL OAS1 OAS3 RNASEL BLK KMT2C FOXO1 SOCS3 NDUFC2 FBXO32 NFKB1 PIN1 FASLG ITGAL TRIM63 ITGA4 TNFRSF18 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 IL2RA NCR3 CD200R1 HCST MUC12 LILRA6 MUC15 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 PTPN4 NCR3LG1 LAIR2 MICA MUCL1 MUC3A MICB MUC5AC NPDC1 MUC3B GLYCAM1 LILRB1 KIR3DL1 LGALS3 KIR3DL2 CFP LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 MUC1 CD8A MUC2 KLRF1 CD300C CLEC4G KLRB1 MUC7 KIR2DL1 MUC4 KIR2DL2 MUC6 KIR2DL3 MUC16 KIR2DL4 CD300LD MUC17 KLRC1 CD300LF MUC19 CD300LG CD160 CRTAM MUC5B MUC20 ULBP1 MUC21 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 WWTR1 YES1 EEF2 SMARCA4 MLEC CTSV CTSL CTSK GBP7 TRIM8 TRIM6 YAP1 TRIM5 TRIM2 TRIM3 CSH1 RELA XAF1 CIITA TRIM68 TRIM62 TRIM46 TRIM48 ARPC1B TRIM45 ARPC1A NPM1 TRIM35 TRIM38 TRIM31 TRIM34 ITCH KLC1 IFITM3 KLC4 IFITM2 KLC3 IFIT5 KLC2 ARPC4 IFI35 ARPC5 IFI30 ARPC2 IFIT3 ARPC3 IFIT2 TRIM29 NF2 ACTR3 TRIM26 ACTR2 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR RAB9B KIF5B IRF8 IRAK1 KIF5A IRF6 NCKIPSD IRF9 SAMHD1 HLA-DOA HLA-DOB LAG3 IL2 CTSO IL3 CTSF IL6 MGST1 CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG CSF1 C4A EED CAT RETN SOD2 FUCA2 KRAS MMP1 MMP2 DNAJC3 JUNB RNF111 PRKCB CST3 PRKCQ CRKL MAPKAP1 NEDD4L CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 NFATC2 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI CDK13 C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A ASH2L C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 CD46 C1QB TEAD2 C1QA C1S C1R TEAD3 TEAD4 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC ICOSLG SNAP25 RAB3A DNAJC5 IL1RN WWP1 IL18RAP IL1R2 IL4 TOLLIP PTPN20 PTPN23 IL18BP IL13 IL1RAPL1 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 CSF2 PTPN7 PTPN5 IL18R1 PTPN2 CNPY3 TLR8 CTSB FKBP5 KPNA7 KPNA4 KPNA5 GBP1 CSF1R KPNA3 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 FANCC PYGL MMP25 TIMP2 OLR1 SERPINB3 BCL6 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 GSTP1 AGA AOC1 AGL ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B WDR5 RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RNF34 RAB5B NLRC4 RAB5C BRI3 HVCN1 GPR84 RAB6A RBBP4 TXNDC5 TRAPPC1 RBBP5 RAB4B PTPRB PTPRC NIT2 RBBP7 ITGAM ITGB2 FCAR ALAD FCGR3B PGM2 ACP3 SNAP29 PML PGM1 RNASET2 TNFRSF1B PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 SOX2 CPPED1 RAB10 NFASC TSPAN14 FCGR2A RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 TWIST1 TXN CHIT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PRG3 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 LIFR CD47 CD44 KCTD6 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 LAIR1 SMURF1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CASP1 CD93 CASP2 CD300A IRAG2 OPRM1 ATAD3B OSCAR TYROBP DOK3 COPB1 IFNG ADGRG3 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 POMC CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 CSK JAK2 NAPRT ADGRE3 HGSNAT FGB DYNLT1 ATP6AP2 FGA PLAUR MMP8 MMP9 FGG CHI3L1 PDXK CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN PROS1 F2 CLTC CLTA CXCL8 AP2A1 CXCL2 AP2A2 AP2M1 CCL11 CCL3L3 CCL5 NPC2 CCL4 CCL3 CCL2 SAR1B CCL19 CCR1 AP2S1 CCL22 CCL20 CXCL10 AP2B1 P4HB POU2F1 LBP VASP STAT5A IL10RA ITK TRAC CD3G FLNA CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 FCGR3A MYH2 MYO10 MYO1C AMPD3 APRT PNP PPP3CA PPP3CB PPP3R1 NFATC1 DNM2 EGR1 JUND FOSB GBP5 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 SLA SLA2 SOCS2 SOCS6 SH2B3 IKBKE IRF7 TANK ACTR1A NEK2 CEP290 NFATC3 TUBB DCTN2 DCTN3 MEFV PSTPIP1 SUGT1 CALM3 CALM2 ATP8A1 IL34 GAB3 ATP11B ATP11A CARD11 MALT1 ATP8B4 RELB CLEC7A CARD9 MAP3K14 GBP6 ANO6 CENPX KIF23 KIF20A DGAT1 FABP5 PRL SNCA DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 SIKE1 IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R TNF CEBPD STAT6 POLR1C POLR1D AGPAT2 GM2A ARSA ASAH1 PSAP TKFC MBL2 GLA IL17RC IL17RA IL17F IL17A CRK UBE2L3 FADD CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 IL1A IL1B PELI1 TLR4 GSN FNTA TICAM2 TICAM1 PKP1 LY96 SDCBP MAOA HMGB1 CASP8 CASP5 CASP4 DSP IRF1 IRF2 DSG1 NCSTN ADAM10 PSEN1 FBXL18 FBXL7 DNM1 FCER2 DNM3 MAPK12 MAPK13 SDC1 HPSE GH1 LYN INPP5D PIK3CG PIK3R6 PIK3R5 BTK ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 JAK1 CISH IL12RB2 HSPA9 IL10 SERPINB2 SOCS5 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 AAMP PPIA AHCYL1 KPNA2 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ADAM17 CYFIP2 HMOX2 TEC STK10 FLT3 IRS1 IRS2 EIF4E3 IFIT1 PIK3CB TCIRG1 PPM1B EIF4E2 FLNB FGF2 CAPZB MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS WASF3 ATP6V1G1 ATP6V0B ATP6V0E1 CD180 LY86 ATP6V1G2 PTPN13 EEA1 PDPK1 TASL RBSN FLT3LG IRF5 GAB2 PIK3CA PIK3R3 ATP6V1B2 TLR9 PIK3C3 TRIB3 ATP6V0D1 FAF2 SOS1 SH3RF1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS RHOU ATP6V0A2 THEM4 ATP6V1H MAPK1 ATP6V0A4 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PTPN1 PTPN11 PLD2 UNC93B1 TLR3 CAMK2B CAMK2D SRC CAMK2A CKAP4 ZAP70 LRRC7 CALM1 DOCK2 CAMK2G DOCK1 ANAPC7 MOSPD2 UBE2C PTK2B UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 ARMC8 FBXW11 OPTN SEM1 APP F13A1 LAMP2 HGF ARG1 SERPING1 PGLYRP4 PGLYRP3 STXBP2 DEFB105B PGLYRP2 KIF5C LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B KIFAP3 S100A7A HSPA5 HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 KIF3B SERPINA3 DEFB117 ORM1 DEFB116 SLC11A1 KIF3C SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 KIF4B DEFB112 ORM2 RNASE3 KIF4A DEFB110 TLR1 DEFB130A BPI KIF11 PRTN3 QSOX1 TIMP1 DEFB130B S100A9 CAP1 DEFB4B S100A8 KIF15 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 KIF22 DEFB123 STX4 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A S1PR1 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 KIF26A ACLY ATG5 ATG12 SLC27A2 TCF7L2 CDKN1A TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ACAA1 EIF2S2 EIF2S1 EIF2S3 ATF3 TREM2 TNRC6C MOV10 MYCN STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 HMOX1 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 NUP214 IDH1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 HSPA8 ICAM1 TNFSF13 VAMP2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 APAF1 CASP3 CFD C3 GZMM CFB FURIN VAPA IL1RL1 IL33 CCT2 ROCK1 CUL3 KIF3A VCAM1 RBBP6 VIM AP1G1 ZBP1 AP1S2 TREX1 AP1S1 DDX41 ITGB7 AP1S3 DTX4 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 NLRP4 TRIM32 HLA-A TRIM21 CD8B TRIM56 ELMO1 CD28 HEXB TNFRSF1A GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 NEDD4 MKRN1 FRK CBL PLCG1 CDKN1B FZR1 FNTB SKP2 CDK4 H2AX CSF3R H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CHRNB4 MYLIP NEU1 FBXL21P CTSA REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 F9 PROC F10 PROS1 FURIN PROZ F2 BGLAP GAS6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R5D PPP2R1B MLXIPL PPP2R1A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases SERPINB1 IL18 CASP5 IL1B CASP4 CALM3 CALM2 GSDMD CALM1 CASP3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 OAZ1 OAZ2 ADRM1 OAZ3 AZIN1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants FLT3 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR7 SC5D DHCR24 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA NGFR LINGO1 MAG OMG RTN4 MCF2 RHOA NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism CD38 BST1 NMNAT3 NMNAT2 NMNAT1 NUDT12 NADK NNMT NAPRT NADSYN1 NMRK2 NMRK1 NAXE NADK2 NAXD NAMPT RNLS SLC22A13 NT5E QPRT SLC5A8 PARP10 SLC25A51 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle ARL6IP5 GAD1 GAD2 CHAT SLC18A3 SLC17A7 NAAA STX1A CASK LIN7A LIN7C LIN7B APBA1 SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT GLS2 SLC6A1 CPLX1 RIMS1 UNC13B ALDH5A1 GLS DNAJC5 SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC1A1 SLC1A2 SLC1A3 SYN3 SLC1A6 SYN2 SLC1A7 HSPA8 VAMP2 SLC38A2 MAOA SYN1 SLC6A11 SLC6A12 SLC5A7 TSPOAP1 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle CLTC IQGAP1 PTK2B VANGL1 WWP2 ARHGEF7 PIK3R2 PIK3R1 RHOU ARHGEF6 STAM ARHGAP31 ARHGAP30 SPTAN1 STAM2 GIT1 TXNL1 HGS MYO6 CDC42 DEPDC1B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 SRC ITSN2 PAK1 PAK3 SRGAP2 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair PCNA ERCC6 PCLAF REV1 ISG15 USP43 SPRTN MAD2L2 REV3L ISY1 FIRRM SIRT6 PNKP POLK POLE OGG1 PIAS3 UBE2T RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 UBE2L6 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 HERC2 ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 CDK2 MAPK8 MDC1 FEN1 USP1 DTL UBE2I SUMO1 RBX1 TRIM25 NFRKB CCNH PIAS4 POLR2A POLR2B POLR2C BRCC3 POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J NPLOC4 POLR2K POLR2L MSH3 GTF2H1 GTF2H2 BAP1 GTF2H3 WDR48 GTF2H4 BABAM1 GTF2H5 BABAM2 CDK7 ERCC3 POLI ERCC2 UIMC1 MNAT1 UFD1 ACTB UBB ACTL6A UBC DDB2 RPS27A FAAP100 FAAP24 FAAP20 UBA7 FANCM ERCC8 FANCL FANCA FANCB FANCE FANCG FANCF KPNA2 TP53 DCLRE1C RIF1 MCRS1 POLL NHEJ1 UBE2B POLM TDP2 TDP1 PARG APEX1 ADPRS POLQ KDM4B YY1 RUVBL1 USP7 ABL1 PMS2 MPG MUS81 GPS1 SLX4 EME1 INO80C EME2 INO80B GEN1 INO80E SLX1B VCP INO80D COPS4 SPIDR FANCI COPS2 FANCC CLSPN RNF4 FIGNL1 POLB RNF168 NSD2 CENPX ACTR5 RAD23A ACTR8 RAD23B MSH2 RTEL1 ABRAXAS1 USP10 TP53BP1 UVSSA H2AX TFPT LIG1 H2AB1 MSH6 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 DCLRE1B H2BC21 DCLRE1A POLN FAN1 RNF8 H2AC8 H2AC6 CHEK2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG MBD4 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 MGMT TERF2 H2BC8 H2BC5 SMUG1 NEIL3 XRCC6 H2BC3 AQR XRCC4 H3-4 NEIL2 XRCC5 PARP1 H2BC1 POT1 LIG4 TERF2IP PPP4R2 NEIL1 TIPIN H2AC20 TIMELESS ZNF830 PPP4C POLH RAD52 MLH1 KDM4A FANCD2 SUMO3 SUMO2 PIAS1 PRPF19 PAXIP1 SMARCA5 CENPS PRKDC BAZ1B XAB2 BLM MRE11 RAD18 BRCA1 BRCA2 RAD51AP1 ELL WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 APBB1 RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 EYA4 PPP5C RMI1 TCEA1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 PPIE CCNA2 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR KANK1 ETV6 GOLGA4 BIN2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INS ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 PTPN1 INSR TCIRG1 IDE PTPRF ATP6V1E1 CTSD ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs RASA3 RASA4 RASA2 NRAS CUL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 KBTBD7 PSMA4 PSMA1 NF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 SPRED3 SPRED2 PSMB7 SPRED1 RASAL2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RASA1 ADRM1 SYNGAP1 PSMC5 PSMC6 HRAS SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DAB2IP RASAL1 RASAL3 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 SEC61A2 SEC61A1 CHUK TIRAP TAPBP IKBKB SEC22B MYD88 CALR B2M HLA-A TLR1 VAMP8 S100A9 PSMB10 PSMD8 PSMD6 TLR6 S100A8 PSMD7 TLR2 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMA5 STX4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK CD14 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 FGA PSMB4 TAP2 FGG PSMB5 IKBKG TAP1 TLR4 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A LY96 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 HMGB1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB ACADL HADHA ECHS1 HADH SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 SENP5 NUP107 SENP2 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 SENP1 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG RWDD3 UBA2 DNMT1 SAE1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency OTC BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A2 CYP1A1 ALOX15 LTA4H MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 TAB1 MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PTK6 CDKN1A CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 NUMA1 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events PRKCA PLCB4 GNAQ ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 NBEA PLCB2 CALM1 CAMK2G PRKCD INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling IFNA2 TRIM6 TRIM5 IFNA8 TRIM2 TRIM3 ARIH1 XAF1 IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 NPM1 TRIM45 TRIM35 TRIM38 OAS2 TRIM31 TRIM34 IFITM3 IFITM2 IFNA10 HSPA5 IFIT5 IFI35 IFNA21 IFI30 RAF1 IFIT3 IFNB1 IFIT2 EIF2AK2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 ISG20 YBX1 PRKRA IRF8 IRF6 TARBP2 IRF9 IFNAR1 SAMHD1 PTAFR FLNA HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 KPNB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 FNTA DNAJC3 STAT2 UBE2L6 HERC5 UBE2N ADAR IRF1 IRF2 HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E HSPA1L HSPA2 ATF6 HSPA1B SOCS1 EIF2S2 IFNGR1 EIF2S1 IFNGR2 EIF2S3 EGR1 IKBKB EIF4E UBE2I GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 IRF7 PSMB8 NUP214 PRKCD SFN UBA52 IFIH1 JAK1 ACTB IKBKG UBB UBC TYK2 PTPN2 RPS27A FAAP100 FAAP24 HSPA8 ICAM1 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 KPNA7 FKBP5 KPNA4 KPNA5 GBP1 KPNA3 FURIN FCGR1BP SPHK1 MAP2K6 STAT1 MT2A VCAM1 FANCC B2M SMAD7 IRF3 MAVS HLA-A TRIM21 GBP6 RIGI NUP205 POM121 NUP107 NUP188 FCGR1A AAAS NUP160 POM121C NUP42 NUP85 TPR CENPX NUP62 NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B PML EIF4E2 FLNB MX2 MX1 EIF4G3 EIF4G2 NCK1 SOCS3 EIF4A2 EIF4A1 IRF5 EIF4A3 NCAM1 PPP2R5A STAT3 BST2 MAPK1 DHX9 PIN1 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CD44 PPP2CA PPP2CB IFITM1 CAMK2B PIAS1 CAMK2D SNCA CAMK2A CASP1 EIF2AK3 CAMK2G CENPS IFNG ABCE1 UBE2E1 CDK1 JAK2 ILF3 PTPN6 IRF4 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 TRIM8 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CLPS CEL LIPF PNLIP PNLIPRP3 PNLIPRP1 PNLIPRP2 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors AP2A1 AP2A2 NPM1 AP2M1 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 BTRC NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 KPNB1 CD4 RCC1 RAC1 RANBP1 RANGAP1 ATP6V1H PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 DOCK2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 ARF1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNT1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDK9 RPS27A CUL5 ADRM1 PPIA HCK PSMC5 PSMC6 SEM1 LCK PSMC3 FYN PSMC4 PSMC1 PSMC2 SKP1 PAK2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis XIAP CYCS STAT3 DYNLL1 UACA BAK1 GZMB CDKN2A DYNLL2 MAPK1 BID PPP1R13B MAPK8 BCL2L11 MAPK3 BAD PMAIP1 YWHAB YWHAE AKT1 YWHAQ YWHAG YWHAH YWHAZ SFN GSDMD NMT1 GSDME PPP3CC BAX C1QBP E2F1 TP63 TFDP1 TFDP2 CARD8 BBC3 BCL2 BCL2L1 AKT2 BMF AVEN TP73 APIP TP53 CASP8 CASP9 PPP3R1 TP53BP2 CASP7 APAF1 DIABLO CASP3 AKT3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species NCF1 PRDX2 CYCS NCF2 PRDX1 NCF4 NUDT2 CAT PRDX3 NOX5 ERO1A TXN2 GPX3 GPX6 GPX5 GPX8 SOD2 GPX7 ATP7A CYBB TXNRD2 CYBA PRDX6 ATOX1 SOD3 CCS TXNRD1 SOD1 P4HB GPX1 GSTP1 AQP8 TXN NOX4 GPX2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) MSH6 MLH1 PMS2 MSH2 MSH3 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i ALG2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CAMK2D CALM1 CAMK2G CAMK2A REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements ATF7IP ZNF547 ZNF224 MBD3 GATAD2B GATAD2A ZNF778 RBM7 ZNF454 CHD4 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 MTA1 MTA3 RBBP7 SMARCE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MORC2 H2AC6 H2AC7 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ZNF141 HDAC1 ZNF382 H2AC20 ZNF418 ZNF354A ZNF136 ZNF649 EHMT2 EHMT1 CHD3 SUMO2 UBE2I DPF1 HDAC2 DPF2 DPF3 ZNF28 CBX5 ZNF273 SETDB1 SS18L1 ARID1A ARID1B ZNF816 ZNF610 SS18 SMARCB1 ZNF264 PPHLN1 TRIM28 ZNF30 ZNF257 SMARCC1 SMARCC2 ZNF33A MPHOSPH8 ACTB SPOCD1 ZNF331 ZNF93 ZCCHC8 ACTL6A MTREX TASOR ZNF708 ZNF324 ZNF534 PIWIL4 DNMT3L BCL7A ZNF320 BCL7C SMARCA2 BCL7B SMARCA4 ZNF765 DNMT3A ZNF317 C19orf84 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 MIB2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRR5 DPY30 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 BRD4 PDCD1 RAC1 COPS5 VAV1 MAPKAP1 IRF1 RPN2 TCF7L2 TUSC3 TCF7L1 RPN1 LEF1 MAGT1 TCF7 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MLST8 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 MTOR TEAD3 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 AKT1 PSMD1 HIF1A ICOSLG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 JAK1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PAK2 RICTOR CUL3 VCP STAT1 MAP3K14 CD28 WDR5 RBBP4 RBBP5 RBBP7 CDK4 PPP2R1B H2AX PPP2R1A PIK3CB H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 AKT2 H3-3B H3C8 H2AC8 H2AC6 PAK3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PDPK1 H2BC15 H2BC11 PIK3R3 KMT2A PIK3CA TRIB3 H3C15 PPP2R5E H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D STAT3 PPP2R5C PIK3R2 H2BC1 PIK3R1 NFKB1 PDCD1LG2 B3GNT3 H2AC20 SPOP THEM4 PTPN11 CDC42 PPP2CA PPP2CB SUZ12 GSK3B CD86 CD80 NFKB2 CSK CD274 MAP3K8 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 WWTR1 YES1 SEM1 LCK FYN SKP1 FOS CUL1 AKT3 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy MAP1LC3A CETN1 FUNDC1 PARK7 ATG5 TOMM20 ATG9A ATG12 ULK1 DYNLL1 TOMM7 ARL13B MFN1 TOMM5 DYNLL2 MFN2 TOMM6 TOMM22 HSF1 IFT88 VCP DYNC1I2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 SQSTM1 PLIN3 DYNC1I1 TBK1 PRKAB2 DYNC1H1 PRKAB1 UBE2D2 UBE2D3 EPAS1 PINK1 USP30 VDAC3 VDAC2 VDAC1 UBE2L3 MAP1LC3B CFTR HSP90AA1 UBA52 HDAC6 PLIN2 TOMM70 UBB UBC DYNC1LI1 PEX5 RPS27A NBR1 DYNC1LI2 UBE2V1 OPTN PRKN HSPA8 CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 UBE2N PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly APOC4 A2M APOC3 APOC2 APOC1 P4HB APOA2 ZDHHC8 APOA1 APOA4 APOB PRKACG PRKACA PRKACB APOE ABCA1 SAR1B MTTP CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling CD86 CD80 PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 RICTOR MAP3K8 PIK3CB MLST8 PIK3CD AKT2 MAP3K14 MTOR LCK CD28 FYN PRR5 PDPK1 AKT1 PIK3R3 PIK3CA MAPKAP1 AKT3 TRIB3 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B1 SLCO1B3 ABCC1 ABCG2 ALB GSTA1 UGT1A4 HMOX1 BLVRB HMOX2 ABCC2 BLVRA UGT1A1 FABP1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B2 SRD5A3 CGA HSD3B1 CYP17A1 HSD11B1 HSD11B2 STARD3NL CYP19A1 POMC CYP11A1 STS SRD5A2 SRD5A1 HSD17B1 CYP11B2 SERPINA6 HSD17B2 CYP11B1 TSPO LHB HSD17B3 HSD17B12 CYP21A2 FDXR STARD3 STARD4 STAR STARD6 AKR1B15 HSD17B14 FDX1 HSD17B11 FDX2 AKR1B1 TSPOAP1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation RPS6KA1 ATF1 MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 RPA1 ERCC8 DDB1 RPA2 XPA POLE4 CUL4A RPA3 PPIE ERCC4 ERCC1 POLE2 POLE3 ERCC5 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGAP32 ROCK1 ROCK2 ARHGAP44 PREX2 ARHGAP40 ARHGDIA HMOX2 STARD8 ARHGAP8 ARHGAP45 AAAS ARHGEF25 CIT IQGAP1 PKN3 PLD1 IQGAP3 STX5 ARHGAP22 ARHGAP20 SRGAP1 STARD13 JUP VMA22 ARHGAP29 ARHGAP24 PKN2 PKN1 ARHGAP31 FAM13A STK10 ARHGAP30 SLK C1QBP ARHGAP9 ARHGAP11B TEX2 ARHGAP4 DDRGK1 TAGAP PLEKHG3 PLEKHG4 BCAP31 ARAP1 GMIP ARHGAP11A TJP2 ARHGAP10 DAAM1 TRIO RASGRF2 PLEKHG6 ARHGEF10L AKAP13 PREX1 STOM MCF2L ARHGEF40 FARP1 VAV3 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 DEF6 VAPB KTN1 ARHGEF15 PLEKHG5 DLC1 TMEM87A DIAPH1 ARHGEF17 FLOT1 ARHGEF19 SCFD1 DIAPH3 FLOT2 ARHGEF18 VAV1 VAV2 ANLN TIAM1 FAF2 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF KALRN RHOA EMC3 CAVIN1 MYO9A ABR RTKN ECT2 ARHGEF28 ARHGAP19 ARHGAP18 MCF2 NET1 RHPN1 RHPN2 ACBD5 MACO1 ARHGAP28 ARHGAP23 FMNL3 ABCD3 SOWAHC DOCK2 TFRC SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP42 OPHN1 STBD1 ARHGDIB LBR TMPO ARAP2 ARAP3 BCR DEPDC1B VAMP3 ARHGAP21 LMAN1 PGRMC2 RACGAP1 YKT6 CAV1 MCAM ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SLC39A2 SLC39A1 SLC39A3 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis IRF1 XIAP IRF2 CYCS CHMP3 CHMP6 TNFRSF10B CHMP7 TNFRSF10A BAK1 GZMB ITCH FAS FASLG RIPK1 OGT CASP1 STUB1 UBE2L3 TRAF2 TNFSF10 HSP90AA1 CDC37 UBA52 BIRC2 FADD ELANE BIRC3 GSDMD GSDME BAX TP63 RIPK3 IL18 IL1A IL1B PELI1 UBB UBC RPS27A CHMP4C CHMP4B CHMP4A PRKN SDCBP MLKL CHMP2B CHMP2A TRADD HMGB1 TP53 CASP8 CASP5 CASP4 FLOT1 FLOT2 CASP3 PDCD6IP ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 SEC22B SERPINA1 SEC23A COPE ARF4 F5 TMED3 F8 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 NSF CTSC CAPZA3 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A TMED2 SPTB DYNC1I1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ANK1 AREG DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 TGFA YKT6 ARFGAP1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RXRA CREBBP CHD9 PPARGC1A NCOA2 NCOR1 NCOA6 TBL1XR1 EP300 SMARCD3 MED1 TGS1 HDAC3 RORC RORA NR1D1 NRIP1 CARM1 TBL1X NCOA1 CPT1A SREBF1 HELZ2 PPARA REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 UBC TICAM2 TICAM1 RPS27A TBK1 TRAF3 OPTN LY96 UBA52 CD14 IKBKE TANK UBB TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation RELA MAP3K7 RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CARD11 IGKV2D-28 MALT1 IGKV4-1 IGHV7-81 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 TAB1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV TRAF6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 PRKCQ UBE2N NFKB1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 V1-11 V1-16 V1-13 CHUK V2-8 IKBKB V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 LYN PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 RASGRP4 CUL1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors LDLRAP1 CUBN AMN APOA2 ACO1 APOA1 ABCD4 APOA4 SLC2A1 PRKG2 PRSS3 LPL LMBRD1 LDLR GPIHBP1 APOC3 LRP8 FLAD1 RFK SLC52A2 APOB SLC52A3 ACP5 SLC52A1 NOS3 ENPP1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR PDZD11 GCHFR GCH1 SPR PTS NNMT PNPO AOX1 NAMPT SLC5A6 ACACA STARD7 FASN COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A SDC4 SDC2 SDC3 SLC46A1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 AKT1 IDH1 COQ2 GSTO1 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC PCCA HLCS MCCC1 PCCB ACACB NUDT12 NADK CYB5R3 THTPA TCN1 NMRK2 NMRK1 RBP4 NAXE RBP1 LRAT NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MOCOS MMAB SLC22A13 QPRT SHMT2 MTRR SLC25A51 SLC25A19 CD38 GPHN HSP90AA1 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 NMNAT1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 TCN2 CD320 AKR1C1 TTR CBLIF AKR1C4 MMACHC MMADHC PLB1 BST1 VNN1 HSPG2 APOE GSTO2 AGRN APOC2 ABCC1 MTR SLC2A3 CALM1 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 BCO1 VKORC1 AKR1B10 NAPRT CLPS RBP2 LRP10 LRP12 PNLIP PDXK NADK2 RDH11 AKR1C3 SLC5A8 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation YARS1 EEF1E1 KARS1 EPRS1 NARS1 IARS1 PPA1 TARS1 AARS1 CARS1 HARS1 FARSA FARSB RARS1 LARS1 AIMP1 AIMP2 WARS1 QARS1 MARS1 GARS1 DARS1 SARS1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP9 DUSP4 TYK2 DUSP6 DUSP7 DUSP10 IL6R CDK1 IL6 PEA15 MAPK1 DUSP5 DUSP2 DUSP1 JAK2 DUSP16 JAK1 MAP2K1 MAP2K2 MAPK3 PTPN11 DUSP8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 SLC19A3 SLC19A2 THTPA TPK1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA1 GRIA2 GRIA3 GRIA4 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C CDK2 MDC1 CLSPN SUMO2 UBE2I RNF4 RNF168 NSD2 PIAS4 BRCC3 UBA52 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN UBB TOPBP1 SIRT6 ATRIP BARD1 RFC5 UBC RMI2 H2BC26 RFC3 RFC4 RPS27A H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB DCP1A ZFP36L1 EXOSC7 EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway CHST8 CHST10 FUT3 FUT8 MAN2A2 CGA MAN2A1 LHB MGAT2 FUCA1 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion F9 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development ROBO2 WFDC2 MECOM GFRA1 OSR1 GATA3 HOXA6 BMP4 PAX8 PLAC8 FOXC2 ITGA8 CTNNB1 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 GREM1 SALL1 SIX2 EYA1 FGF2 HOXB4 IRX1 ID4 LFNG IRX2 JAG1 SLIT2 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 POU3F3 WNT4 WNT11 ITGB1 EMX2 PCDH19 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 CLTC CLTB FZD5 WNT5A AP2S1 ROR1 CLTA ROR2 AP2A1 AP2A2 AP2B1 AP2M1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils PXDN LOXL1 PCOLCE LOXL2 TLL2 TLL1 LOX LOXL3 LOXL4 BMP1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAH SFN YWHAZ YWHAE PDPK1 AKT1 AKT2 YWHAQ CAV1 YWHAG YWHAB AKT3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility ITGA3 CRK LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 RAP1B RAP1A ITGA2 MET DOCK7 RAPGEF1 TNS4 TNS3 SRC RAC1 GAB1 HGF PTK2 CRKL ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 HBB APOA1 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 BACH1 CLOCK NPAS2 TLR4 HELZ2 RAI1 CREBBP CHD9 MAFK NCOR1 SLC46A1 MEF2C TBL1XR1 NFE2L2 EP300 LY96 CLEC1B MED1 TGS1 MEF2D PGRMC2 APOB HBA2 RORA HMOX1 SIRT1 XPO1 PPARA CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway CDC42 LCK CD28 RAC1 FYN CD86 CD80 PAK2 VAV1 PAK1 PAK3 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 ARPC1A LDLRAP1 AP2M1 BIN1 STAM2 ARPC4 STON1 GPS1 ARPC5 STON2 ARPC2 ARPC3 SNX18 COPS4 ACTR3 ACTR2 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 CTTN SGIP1 AP2S1 AGTR1 DNAJC6 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 HIP1R AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 FNBP1L SNX9 APOB SNAP91 M6PR SYT2 GAK ARRB1 FNBP1 ARRB2 SCARB2 AMPH PACSIN2 PACSIN3 PACSIN1 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 RAB5B RAB5C TGOLN2 CHRM2 ARF6 HGS RAB5A WASL CD4 GAPVD1 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 TRIP10 DNM1 SLC18A3 DNM2 DAB2 EPS15L1 EPN1 PIK3C2A SYT9 GRK3 PICALM VAMP8 DNM3 IL7R TFRC PIP5K1C CFTR SYT1 IGF2R UBA52 STAM HIP1 OCRL UBB SYNJ2 SYNJ1 UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 HSPA8 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG ARFGAP1 BTC EPGN HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON SPOP ITCH CUL3 KIF7 IHH SMO GPR161 KIF3A PTCH1 GLI3 GLI2 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 ARRB1 PSMD2 RBX1 ARRB2 PSMD3 PSMD1 CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 NUMB PSMD13 PSMA7 PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 PSMC2 ULK3 GRK2 DZIP1 SPOPL REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway FYN SH3KBP1 VLDLR RELN DAB1 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LDLR APOE LIPC LDLRAP1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation RXRA MED19 MED18 SREBF2 MED11 RELA WNT1 NFKB1 MED9 MED29 KLF5 MED28 MED22 TGFB1 MED21 HDAC3 CDK19 CEBPB TBL1X MED13L ANGPTL4 PCK1 NCOA1 LPL EGR2 FABP4 CDK8 NCOR2 NCOR1 TBL1XR1 PLIN1 THRAP3 LEP FAM120B CD36 PPARGC1A NCOA2 NCOA6 NCOA3 CCNC SMARCD3 CCND3 CARM1 ADIPOQ CDK4 MED16 HELZ2 MED15 KLF4 MED17 CREBBP CHD9 MED12 MED14 MED13 TNF MED10 EP300 EBF1 WNT10B NR2F2 ADIRF SLC2A4 MED1 MED30 ZNF638 TGS1 CEBPD MED31 ZNF467 MED8 MED4 MED27 MED6 MED26 MED7 MED23 MED25 CEBPA MED24 MED20 PPARG PPARA DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CREBBP BMAL1 KMT2A CLOCK TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 YAP1 SERPINB13 ABL1 ITCH GPAM ARID2 ESR1 AUTS2 IL2 IL3 TCF3 LDB1 SIN3B DPY30 WDR5 CR1 ELF1 ELF2 SMARCD1 SMARCD2 FOXP3 SMARCD3 CCND3 CCND2 RBBP5 CDK6 BLK SMARCE1 KMT2D H2AX SPI1 PML H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 MYB EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ ZFPM1 H2BC15 PRKCQ TAL1 H2BC11 KMT2A CBFB ITGA2B SOCS4 GATA2 H3C15 OCLN H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 GP1BA SETD1B SETD1A NFATC2 CCND1 SIN3A TJP1 LMO1 YAF2 LMO2 PTPN11 LIFR KCTD6 TNFRSF18 ASH2L TNRC6C MOV10 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 RSPO3 SRC TNRC6A TNRC6B CLDN5 NR4A3 RNF2 PSMD8 PSMD6 CBX8 PSMD7 PHC2 TCF12 MYL9 PHC1 PAX5 PSMD2 CBX4 PSMD3 CBX2 PSMD1 PHC3 ARID1A IL2RA ARID1B GATA1 AXIN1 IFNG CCNH PSMA5 PSMA6 PSMA3 GATA3 PSMA4 THBS1 PSMA1 SMARCB1 PSMA2 LGALS3 UBA52 PSMD12 PSMD11 PCGF5 PSMD14 PSMD13 PSMA7 HIPK2 SMARCC1 SMARCC2 PSMB6 RYBP CDK7 PSMB7 PSMB4 MNAT1 PSMB5 PF4 UBB PSMB2 CSF2 ACTL6A PSMB3 CREBBP UBC PSMB1 RPS27A KAT2B CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 SMARCA2 PSMC4 SMARCA4 ACTL6B PSMC1 CSNK2B PSMC2 TP73 CTSV CTSL CTSK PBRM1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KPNA6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins DEFA5 DEFA3 ART1 DEFA1B PRSS3 PRSS2 CD4 DEFA6 DEFA4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNA6 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor RASGRF2 CAMK2B NRAS CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism MTR MTRR MMAA MMUT MMAB MMACHC MMADHC DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF1 ALYREF DDX39B CPSF3 CPSF2 SRRM1 DHX38 NXF2B SYMPK NXT1 UPF3B MAGOHB EIF4E RNPS1 NUP205 WDR33 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG GALE DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide VCP TCF25 ANKZF1 KLHDC10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism ACADSB ACAD8 MCCC2 ECHS1 ACAT1 MCCC1 BCAT1 SLC25A44 BCAT2 ALDH6A1 HIBADH PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH HSD17B10 DLD GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation OGDH KGD4 GCSH GLDC AMT DLST DLD CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly CEP41 CEP43 IFT172 KIFAP3 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 RPGRIP1L CCT3 PRKACA WDR35 IFT88 SMO TCP1 KIF3A TTC21B WDR19 IFT122 KIF3B MKS1 KIF3C ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CEP97 YWHAE CNGA4 TUBB4B KIF17 BBS5 TUBB4A BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 YWHAG BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B HSP90AA1 ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 HDAC6 RHO RAB11A ATAT1 TTC8 CNGB1 PPP2R1A CPAP DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 PDE6D MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 TNPO1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DDX21 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway UBC TAB3 RPS27A ALPK1 TAB2 MAP3K7 TRAF6 UBA52 UBB TIFA TAB1 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 NGF PLCG1 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events HRAS MAPKAPK3 RALGDS RALB MAPK12 MAPK13 MAPKAPK2 NRAS MAPK14 MAPK11 RALA SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL3 ITGA1 RHOC HSP90AB1 RHOA RHOB ROCK1 ROCK2 PLXNC1 MET SEMA6A PLXNA4 SEMA6D SEMA7A CDK5R1 PLXNB3 TREM2 SEMA3E SEMA4A CDK5 SEMA5A RND1 MYL9 GSK3B TYROBP SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 FARP2 HSP90AA1 ERBB2 CD72 ARHGAP35 PLXND1 CFL1 PTPRC PLXNA1 PLXNB1 TLN1 SEMA4D PAK1 PAK3 LIMK2 RAC1 LIMK1 MYL12B FYN MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 MYH10 PAK2 NRP1 CRMP1 ITGB1 DPYSL4 DPYSL5 DPYSL2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism CYB5B VAPA GAL3ST1 CERK GBA3 GBA2 MFSD2B SMPD3 SMPD2 SPHK1 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLPP3 SUMF1 PLPP2 B3GNT5 PLPP1 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 SGPL1 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG ACER2 HEXB ARSD ACER1 HEXA B3GALNT1 GLB1L3 B3GALT4 M6PR ACER3 GLB1L2 GALC GLA GLB1L GLB1 SPTLC1 ARSB SPTLC2 SPTLC3 ORMDL2 ORMDL3 SPTSSB SPTSSA ORMDL1 VAPB PRKD3 PRKD2 PRKD1 SPNS2 ABCG2 ALDH3B2 ALDH3B1 FA2H DEGS1 DEGS2 SPHK2 SAMD8 SGMS1 ABCC1 SGMS2 OSBP SGPP2 SGPP1 CSNK1G2 KDSR ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CERS3 ST3GAL2 CERS4 ST3GAL3 CERS5 CTSA CERS6 CERS1 CERS2 PPM1L SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 GNAQ GNA15 PLCB3 PLCB1 FFAR1 PLCB2 GNA11 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A3 SLC26A9 SLC26A6 SLC26A11 SLC26A1 SLC26A4 SLC26A7 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly APOC4 APOB APOC1 MTTP P4HB M PHASE%REACTOME%R-HSA-68886.5 M Phase PRKACA YWHAE EML4 CDCA5 NCAPG YWHAG ARPP19 NCAPH ENSA SIRT2 USO1 NCAPD2 TUBB8 RAB2A IST1 VRK1 LEMD2 TUBB8B NUMA1 FIRRM ESPL1 RAB1A RAB1B GOLGA2 FBXO5 BLZF1 KPNB1 SPAST CC2D1B CNEP1R1 PTTG1 MASTL GORASP2 GORASP1 PPP2R2D CHMP4C CHMP4B CHMP4A PRKAR2B PRKCB CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 TUBB PSMB6 CEP131 PSMB7 HAUS4 HAUS3 CSNK1D PSMB4 HAUS6 PSMB5 HAUS5 CSNK1E TUBG2 LEMD3 UBB TUBG1 PSMB2 PSMB3 TUBB6 HAUS2 TUBB3 HAUS1 MZT2B TUBB1 UBC MZT2A PSMB1 NME7 AKAP9 RPS27A CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 ADRM1 CSNK2A1 DCTN3 HAUS8 PSMC5 HAUS7 CSNK2A2 CEP70 PSMC6 CEP72 PSMC3 TUBA4B CEP192 PSMC4 PCNT PSMC1 TUBA4A CSNK2B CEP76 PSMC2 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS KMT5A NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 HSP90AA1 NDC1 RANBP2 SEC13 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 CPAP KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 RCC1 H2BC21 ZW10 MAD1L1 H3-3B CDCA8 H3C8 H2AC8 PMF1 SKA1 H2AC6 SKA2 KIF23 H2AC7 DSN1 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 RCC2 STAG1 H2BC15 NIPBL NDC80 ZWINT STAG2 H2BC11 RAD21 KIF20A KIF18A RPS27 AHCTF1 H3C15 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 H2AC20 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 LPIN1 CENPT LPIN2 DYNC1H1 CENPU LPIN3 NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 TIAM1 RAC1 NTRK2 BDNF CDK5 CDK5R1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 PSEN1 UBB NOTCH2NLA UBC NOTCH2NLC NOTCH2NLB RPS27A MDK JAG2 JAG1 DLL1 NOTCH2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA AREG EGF MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CLIP1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G2D PLA2G2E MBOAT1 PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 ABHD4 PLAAT1 PLAAT3 PLA2G2A PLAAT2 PLAAT5 PLAAT4 PLA2G4A PNPLA8 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 LPCAT3 PLBD1 PLA2G2F REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A11 SLC6A13 SLC6A12 SLC6A1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 LIPC LDLRAP1 UBA52 AP2M1 CUBN AMN APOA1 LSR NPC1 SOAT1 SOAT2 APOE NPC2 CES3 UBB MYLIP NR1H2 APOC4 UBC AP2S1 NR1H3 LDLR RPS27A APOBR AP2B1 APOC1 NCEH1 APOB BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import TOMM20 GFER OTC TOMM7 TOMM5 TOMM6 SAMM50 TOMM22 MTX1 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX19 COX17 ATP5MC1 TIMM50 PITRM1 GRPEL1 GRPEL2 LDHD CYC1 DNAJC19 COA4 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 HSPD1 ACO2 HSCB TIMM17A TIMM17B COA6 SLC25A4 SLC25A6 TIMM23 TIMM22 HSPA9 TIMM21 TOMM70 SLC25A12 PMPCB FXN PMPCA SLC25A13 NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B VPS28 CHMP4A TSG101 VPS37C VPS37D VPS37A VPS37B GABARAP CHMP2B CHMP2A MVB12B EEF1A1 MVB12A UBAP1 UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A RNASE1 CHMP3 ATG12 GFAP ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B HSP90AB1 DYNLL2 HBB TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B LAMP2 ATM MTERF3 WIPI1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates NUDT13 AK1 RRM2 AK2 AK4 NME1 AK5 AK6 AK7 AK8 DCTPP1 AK9 GLRX NME2 NME3 NME4 DCTD TXNRD1 CMPK1 TYMS CTPS2 CTPS1 RRM1 RRM2B DTYMK TXN GUK1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate SRD5A3 MVD DOLK DOLPP1 DHDDS NUS1 DHRSX DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k ALG1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling DUSP6 DUSP7 KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G DUSP8 DUSP9 IQGAP1 MRAS FAM114A2 QKI NF1 KIAA1549 DUSP10 ESRP1 TRIM24 FXR1 FN1 PHB1 AGTRAP MAP3K11 ARAF AP3B1 PEBP1 SHOC2 CSK AGGF1 JAK2 TENT4A DUSP16 MARK3 SPRED3 FGB SPRED2 BRAP SPRED1 FGA VWF KSR1 KRAS PPP1CB FGG PPP1CC BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes ACSS3 CXXC1 AGPAT2 ABL1 KANSL1 KANSL2 KANSL3 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 TADA3 OGT DPY30 WDR5 PSIP1 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA KMT2A H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 SETD1B SETD1A HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 PHF20 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 KAT8 HCFC2 WDR82 PAXIP1 PEX11A AJUBA KAT14 ZZZ3 HCFC1 TADA2A SGF29 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC PHF20L1 NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 BOD1L1 CREBBP MED17 MBIP MED12 TASP1 MED14 DR1 MED13 BOD1 KAT2B KAT2A YEATS2 MED10 MEN1 AKAP8L PAGR1 MED27 KDM6A SIRT1 MED23 MCRS1 MED24 MED20 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED1 CITED2 CITED4 CGA YY1 HSPD1 ERBB2 VEGFA CDKN1A EGFR DEK NPM1 APOE ATAD2 CREBBP YEATS4 NOP2 TFAP2A TFAP2B ESR1 EP300 WWOX MYC TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 KDM5B CGB8 TGFA KIT MYBL2 PITX2 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly APOA1 APOA4 APOB APOE APOC2 APOC3 SAR1B MTTP P4HB APOA2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant F9 F10 F8 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway BAIAP2 ABI2 PIK3R2 PIK3R1 ABI1 NRAS RHOA THEM4 RICTOR ROCK1 ROCK2 PRKACG PRKACA CTNNB1 PRKACB SPHK1 ELMO2 CDC42 MLST8 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 MTOR HSPB1 SHC2 NOS3 PRR5 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA NCF2 KDR CRK NCF4 PTK2B PXN BRK1 HSP90AA1 MAPKAPK2 JUP CTNND1 PLCG1 CTNNA1 SHB CYBB CYBA SH2D2A PIK3CB MAPKAPK3 CDH5 AXL NCK2 NCK1 RASA1 AKT2 MAPK14 PRKCZ MAPK11 PAK1 PAK3 RAC1 HRAS PRKCB WASF3 BCAR1 AHCYL1 FYN VAV3 PDPK1 NCKAP1L WASF1 PAK2 WASF2 PTK2 PIK3CA ITGB3 VAV1 VAV2 CAV1 AKT3 ITGAV TRIB3 MAPKAP1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair PCNA KDM4B ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 CHEK2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 PARP1 H2BC1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MAPK8 MDC1 KDM4A FEN1 SUMO2 UBE2I SUMO1 PAXIP1 SMARCA5 PIAS4 BRCC3 UBA52 PRKDC BAZ1B BAP1 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 APBB1 UBC RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 RPS27A EYA4 PPP5C RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 KPNA2 RAD17 DCLRE1C TP53 CCNA2 RAD1 RIF1 ATM CCNA1 DNA2 POLL NHEJ1 RAD9B RHNO1 POLM TDP2 ATR TDP1 RAD9A POLQ METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors COQ9 DHFR COQ7 COQ6 COQ5 COQ2 COQ4 HSP90AA1 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ACO1 GCHFR GCH1 SPR PTS PRKG2 NOS3 STARD7 AKT1 CALM1 IDH1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells EOMES SOX17 CXCR4 BMP4 PDPN PRDM1 TET2 TFAP2C POU5F1 NANOG NANOS3 CBFA2T2 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism CPOX SLCO1B1 SLCO1B3 ABCG2 UROD GSTA1 UROS ALAS2 BLVRB ABCC2 BLVRA COX15 ALAD FABP1 FECH COX10 PPOX ALAS1 HMBS ABCC1 ALB UGT1A4 HMOX1 HMOX2 UGT1A1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication HDLBP KPNA7 NACA FASN KPNA4 KPNA5 KPNA3 BTF3 RPN2 BAG2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 VCP SPCS2 DNAJA2 PRKG2 SPCS1 OST4 SEC11A RTN3 SEC11C HSPA1B DDOST VIM TMEM258 DAD1 OSTC CANX CALR ACOT2 YBX1 STT3A EIF4E STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 MAP1LC3B KPNA1 XRN1 IPO7 DNAJB11 PABPC1 P4HA1 UBA52 P4HA2 P4HA3 NPLOC4 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UFD1 RRBP1 UBB EIF4E3 UBC DNAJC3 RPS27A EIF4G3 EIF4G2 SUN2 HSPA8 EIF4A2 EIF4A1 HSPA1A KPNA2 EIF4G1 EIF4A3 ATL2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism MAPDA NT5C2 ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling CAPZA1 PRKCSH AGER LGALS3 S100A12 MAPK1 APP S100B SAA1 HMGB1 CAPZA2 MAPK3 DDOST ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria DCXR NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PCNA YY1 RUVBL1 USP7 ERCC6 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ISY1 ACTR5 RAD23A ACTR8 RAD23B UVSSA TFPT LIG1 POLD3 POLD4 POLK POLD1 POLE POLD2 PIAS3 RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 AQR PARP1 ZNF830 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 PRPF19 RBX1 NFRKB CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 CDK7 ELL ERCC3 ERCC2 MNAT1 ACTB UBB ACTL6A UBC RFC5 RFC3 RFC4 DDB2 RPS27A TCEA1 RFC2 RPA1 ERCC8 RPA2 RPA3 PPIE MCRS1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription IRF1 JUN YAP1 H2BC9 H2AZ2 H4C9 H2BC8 RELA H2BC5 H2BC3 STAT3 TCF7L2 H2BC1 NFKB1 TCF7L1 H2AC20 LEF1 TCF7 CTNNB1 STAT1 ATF3 JUND ASH2L MYCN FOSB MYC TEAD1 TEAD2 TEAD3 TEAD4 SUZ12 DPY30 EPAS1 WDR5 HIF1A EED RBBP4 NFKB2 EZH2 RBBP5 RBBP7 H2AX CREBBP H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 NFE2L2 EP300 H3-3B H3C8 H2AC8 WWTR1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS H2BC11 KMT2A H3C15 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism AADAT SLC3A2 ACMSD AFMID SLC36A4 HAAO KYAT1 TDO2 IDO2 IDO1 SLC7A5 KYAT3 KMO KYNU PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease TALDO1 RPIA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW DPM2 PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions ITGB4 DDR2 DRP2 ITGB5 DMD ITGA6 TNC PDGFB TGFB1 ACTN1 ITGA2 HSPG2 UTRN SNTG2 SDC4 SDC2 SDC3 TRAPPC4 SGCE SGCD AGRN SGCA NTN4 SGCB SGCG SNTA1 SGCZ NRXN1 SNTB1 CASK SNTB2 SDC1 PRKCA LAMA5 LAMA2 THBS1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN DAG1 FGF2 PDGFA TTR DTNA DTNB SSPN DDR1 ITGB3 ITGB1 ITGAV DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes KLF4 FOXG1 SMAD2 SMAD4 SMAD3 PCBP4 FOXO1 CDKN1A CDKN1B CCNG2 MSTN FOXO3 FOXO4 GADD45A CAV1 RBL2 BTG1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ZNF420 CREBBP BBC3 BNIP3L PRELID3A PMAIP1 PRELID1 STEAP3 AIFM2 TP53AIP1 TP53INP1 BAX BID TP63 TP73 PPP1R13B TP53 ATM TRIAP1 TP53BP2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome DDX5 ZCRB1 VHL RB1 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism PLPP2 ACER2 PLPP1 ACER1 ALDH3B2 SGPP2 ACER3 SGPP1 ALDH3B1 SGPL1 PLPP3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation SLC26A2 SRD5A3 GALT B3GALT6 B4GALT7 NCAN HEXB HEXA BGN DCN BCAN VCAN GLB1 CSPG5 CSPG4 GALM ADAMTS13 POMT2 POMT1 POMGNT1 B4GAT1 DAG1 PGM1 LARGE1 GALK1 CHSY1 GALE PRELP CHST6 OMD KERA NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 MUC13 CHST14 HSPG2 MGAT2 PAPSS2 MOGS SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B4GALT1 MAN1B1 GPC1 GPC3 GPC2 GALNT12 GPC5 DPAGT1 SEMA5A GPC4 SPON2 SEMA5B GPC6 SPON1 THSD7B MPI ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 EXT1 ADAMTS3 SDC1 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 THSD7A ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 DPM1 ADAMTS12 DPM2 THSD1 DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 NEU1 SSPOP MUC5B MUC20 MUC21 LFNG ST3GAL3 MPDU1 CTSA NUS1 PMM2 GFPT1 DOLK BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DBT DLD ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense UBC GBP1 RPS27A UBA52 GBP2 GBP6 UBE2D2 GBP4 CASP4 CALM3 CALM2 CALM1 UBB DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants FLT3 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels HCN4 HCN3 HCN2 HCN1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 NEURL1B GZMB UBA52 HES5 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 UBB RBPJ NOTCH2NLA UBC NOTCH2NLC MAML2 NOTCH2NLB MAML1 FCER2 RPS27A MDK EP300 JAG2 JAG1 DLL1 MAML3 NOTCH2 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 HDAC2 KAT8 KDM5B SUZ12 KAT14 SETDB1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SMARCB1 AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 SMARCA2 SMARCA4 KDM6A DNMT3A PBRM1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM SLC34A2 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation HBA2 HBB RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway UBA3 UBE2M CHUK TNFRSF18 RELB MAP3K14 PSMD8 PSMD6 TNFRSF6B PSMD7 EDA TNFRSF13B PSMD2 TNFRSF11B EDA2R PSMD3 TNFSF13B TNFRSF1A PSMD1 TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 PSMA5 TNFSF15 PSMA6 CD70 TRAF2 PSMA3 TNFRSF9 EDAR PSMA4 PSMA1 TNFSF6 TNFSF4 PSMA2 LTA TRAF3 CD27 TNFRSF12A TNFSF9 TNFRSF25 UBA52 BIRC2 TNFSF12 TNFRSF13C TNFSF8 BIRC3 PSMD12 TNFRSF11A PSMD11 CD40LG LTBR LTB PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 TNFRSF1B RPS27A TNF FBXW11 TNFSF13 TNFRSF14 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 APOD SLC27A4 LCN12 LCN1 SLC27A6 LCN9 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 OMA1 PHB2 YME1L1 EIF2AK1 DELE1 EIF2S2 EIF2S1 EIF2S3 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 FURIN IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 SPCS3 ISG15 SPCS2 MED13L SPCS1 CD209 SEC11A SEC11C CDK8 IRF3 IFNAR1 MAVS RIGI TLR2 HSP90AA1 EGFR CD14 RAB5B RAB5C BECN1 TLR7 RAB5A KPNB1 PPP1CC TLR4 BCAP31 STAT2 EP300 LY96 MED1 MED30 MED31 MED8 MED4 MED6 MED7 H2BC15 UBE2L6 HERC5 HSP90AB1 HSPG2 SDC4 SDC2 SDC3 AGRN TLR3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TLR6 ELOB XPO1 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 PPP1CA IFIH1 JAK1 PPP1CB UBB MED16 MED15 CREBBP MED17 UBC MED12 TYK2 MED14 MED13 RPS27A NCL MED10 HSPA8 CUL5 CSNK2A1 CSNK2A2 CSNK2B MED27 MED26 MED23 IGF1R MED25 IFNA5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 CUBN CBLIF AMN LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs FLT3 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBIN HSP90AA1 ERBB2 CDC37 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 GNB5 GNGT1 CCT2 GNGT2 CCT3 TCP1 CCT6B CCT7 GNA14 GNG3 RGS9 GNA15 RGS6 RGS7 GNG2 GNG5 GNG4 GNG7 CSNK2A1 GNA11 GNG8 CCT8 CSNK2A2 CCT5 CCT4 CSNK2B RGS11 GNG10 GNG12 GNG11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER PCNA UBA52 UBB LIG1 UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLE2 POLE3 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 YAP1 HBEGF STAT5A GFAP SPARC STMN1 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 APOE ADAP1 CSN2 NCOR1 CXCL12 MXD4 ESR1 WWOX ADAM17 SRC NRG1 S100B TAB2 EREG NRG3 PGR NRG4 NRG2 BTC ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System YAP1 SEL1L RELA ERLIN1 ERLIN2 ITCH KLC1 RNF185 KLC4 KLC3 KLC2 IFI30 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 KIF5B KIF5A HLA-DOA HLA-DOB LAG3 CTSO CTSF CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG EED RNF111 UBE2V2 RAC1 PRKCB PRKCQ COPS5 UBE2N VAV1 MAPKAP1 NEDD4L CD81 V2-11 DCTN6 V3-4 DCTN5 V3-3 V2-17 DCTN1 DCTN4 V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 CAPZA3 CAPZA2 ACTR10 SOCS1 CD19 IKBKB V2-8 V1-20 MYD88 ASH2L V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 TEAD2 UBE2D2 TEAD3 UBE2D3 TEAD4 ELOB V4-6 ELOC V4-2 RBX1 V4-1 EPAS1 CUL2 HIF1A VHL ICOSLG WWP1 FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B CTSB FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 XDH SIGLEC9 SIGLEC5 WDR5 SEC13 RNF34 RBBP4 RBBP5 PTPRC RBBP7 ITGB2 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 PTPRJ KIF2A ACTR1B CTSH CD33 EVL CTSC KIF2C KIF2B CHUK DYNC1I2 CDC42 PPP2CA KCTD6 PPP2CB LILRA3 DYNC1I1 DYNC1H1 LAIR1 SMURF1 LILRB2 CENPE LILRB3 CD300A OSCAR TYROBP SELL NFKB2 CSK FGB FGA CD274 FGG SYK LCK FYN SKP1 CUL1 CLTC CLTA AP2A1 AP2A2 AP2M1 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 VASP IGHM SH3KBP1 IGHV4-34 IGHV1-2 ITK IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 IGLC3 TRAV29DV5 TRBV7-9 BLNK GRAP2 TRBC1 IGLC1 IGLC2 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 IGKV3D-20 IGHD TRAV19 HLA-DRB4 FYB1 IGKV2-30 ENAH IGLV3-19 HLA-DPB1 IGHV2-70 TRAV8-4 IGHV2-5 HLA-DRA IGLV3-1 LCP2 IGHV3-48 HLA-DRB3 IGLV3-25 HLA-DRB1 IGLV3-27 IGKC HLA-DQB2 IGKV1-39 LAT IGLV3-21 CD101 IGKV1-33 HLA-DQB1 FCGR3A BRD4 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDCD1 PPP3CA PPP3CB LRR1 CCNF UBE2L6 CBLB HERC5 PPP3R1 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 FBXO9 NFATC1 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 DNM2 RNF217 PRKAA1 ATG7 PRKAA2 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 JUND CD207 CALR FBXL4 MLST8 DZIP3 RNF220 FOSB DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 LRRC41 MTOR VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 NCF1 KBTBD6 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 ACTR1A RNF19B UBE3A UBE3B FBXO21 NEK2 UBE2Z FBXO22 NFATC3 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 TRAIP RAB7A RNF41 KLHL42 UBE2V1 DCTN2 CUL7 CUL5 UBA7 UBA6 DCTN3 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 PAK2 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 CARD11 MALT1 ASB13 ASB14 ASB11 RNF6 ASB12 MAP3K14 RNF7 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 PAG1 WAS KIF23 PAK3 COLEC12 KIF20A ITGAV ITGB5 PDCD1LG2 B3GNT3 SPOP SUZ12 DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 GSK3B CD36 KLRK1 NCR2 BCL10 KIR2DS2 CD300LB TREM1 CD300E MAP3K8 KLRD1 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 TAB2 FOS NFKBIB AKT3 JUN PTPN22 CD209 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 UBE2L3 CD14 TLR4 LY96 HMGB1 IRF1 RPN2 TUSC3 RPN1 MAGT1 FBXL18 FBXL7 DNM1 OST4 LGMN DDOST TMEM258 DAD1 OSTC CANX STT3A STT3B KEAP1 DNM3 RNF123 LYN INPP5D PIK3CG PIK3R6 PIK3R5 SIAH2 BTK ARF1 CD40LG JAK1 TRIM4 IKBKG RIPK2 OSBPL1A PIK3CD PRKN CAPZA1 PSME2 PPIA AHCYL1 MAP3K7 VCP CXADR SMURF2 NFKBIA PTEN CD74 JAML CD99 TRAF6 BECN1 PIK3CB CAPZB NCK1 AKT2 CTSD HRAS PDPK1 PIK3CA PIK3R3 PIK3C3 TRIB3 SOS1 SH3RF1 PIK3R4 PIK3R2 PIK3R1 NRAS THEM4 PTPN11 ZAP70 CALM1 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 SEM1 KIF5C KIFAP3 HSPA5 KIF3B KIF3C KIF4B KIF4A TLR1 KIF11 S100A9 S100A8 KIF15 TLR2 KIF22 STX4 CD4 KIF26A TCF7L2 TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ATF3 TREM2 TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 SPTBN2 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CTLA4 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 C3 RICTOR CUL3 STAT1 KIF3A VCAM1 RBBP6 AP1G1 AP1S2 AP1S1 ITGB7 AP1S3 B2M AP1M2 AP1M1 AP1B1 TRIM32 HLA-A TRIM21 CD8B CD28 NEDD4 MKRN1 PLCG1 FZR1 SKP2 CDK4 BLK H2AX H2AB1 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 FBXO32 H2BC1 NFKB1 H2AC20 ITGAL MYLIP TRIM63 ITGA4 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 NCR3 CD200R1 HCST LILRA6 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 CD8A KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 FBXL21P WWTR1 CTSA YES1 CTSV CTSL CTSK DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 IL6 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 IL6R RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway DUSP9 DUSP4 PPP2R5B PPP2R5A DUSP6 PPP2R5D DUSP7 PPP2R5C DUSP10 NRAS UBA52 MAPK1 ARAF PEBP1 RAF1 DUSP16 MARK3 BRAP MAPK3 KSR1 BRAF UBB PPP2R1B PPP2R1A PTPN3 PTPN7 PPP2CA PPP2CB UBC RPS27A PPP5C PAQR3 YWHAB HRAS DUSP5 DUSP2 DUSP1 MAPK12 MAP2K1 MAP2K2 PPP2R5E DUSP8 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling IKBKB UBC TRAF2 RPS27A LRRC14 NLRX1 NLRC5 TRAF6 UBA52 USP14 CHUK TP53 CASP8 USP18 IKBKG UBB IKBIP MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 CPSF4 CPSF7 CPSF1 FUS CPSF3 CPSF2 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 CDC40 DHX9 CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 SYMPK RBM10 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants KIT CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression FASN MLX AGPAT1 ACACA ACLY MLXIPL ACACB EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells CLTC CLTB TIAM1 CLTA AP2A1 EPHB6 EFNB2 AP2A2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 AP2M1 EPHB3 APH1A PSENEN EFNA5 NCSTN EFNA4 APH1B PSEN2 CLTCL1 ADAM10 PSEN1 DNM1 EFNA1 EFNA3 EFNA2 MMP9 AP2S1 MMP2 EPHA2 AP2B1 EPHA5 EPHA4 EPHA7 YES1 EPHA6 RAC1 EPHA8 FYN VAV3 EPHA1 EPHA3 EPHA10 VAV2 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding NTHL1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2BC9 H4C9 H2BC8 H2BC5 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 H2AC1 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 SUZ12 H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 TRIM28 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 RBBP4 EZH2 DAXX NUP37 RBBP7 CBX1 PML H2AC19 H2BC26 DYNC1LI1 H2AC14 DYNC1LI2 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ELK1 ITGB1 H3C15 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type MMAA MMUT IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs IFNG MAPK1 RAF1 JAK2 JAK1 MAPK3 IFNGR1 IFNGR2 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n RFT1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SNAP25 RAB3A ARL6IP5 STX1A SYT1 SLC1A6 GLS2 SLC1A7 VAMP2 CPLX1 RIMS1 UNC13B GLS SLC38A2 PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC17A7 SLC1A1 TSPOAP1 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 RXRB NRIP1 PCK1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway CYP26A1 CYP26B1 CYP26C1 ADH1C DHRS4 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 ALDH8A1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN YES1 HCK SYK FYN ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A8 SLC22A12 SLC22A11 SLC22A7 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOF APOB LPA CETP MTTP P4HB SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea CACNA1D CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 TMIE USH1G STRC MYO15A CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation REXO2 FASTKD5 TBRG4 SLIRP PNPT1 FASTKD2 LRPPRC GRSF1 SUPV3L1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 DYNLL1 DCTN6 DCTN5 ACTR1A DCTN1 DYNLL2 PAFAH1B3 DCTN4 RAB6A CAPZA3 CAPZA2 PAFAH1B1 DYNC1I2 GALNT1 ACTR10 PLA2G4A CAPZB DYNC1LI1 DYNC1I1 RAB6B GALNT2 DYNC1LI2 DCTN2 DYNC1H1 CAPZA1 DCTN3 RAB3GAP2 PAFAH1B2 RAB3GAP1 BICD1 RAB18 BICD2 AGPAT3 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation YARS1 YARS2 NARS1 NARS2 RARS2 CARS1 CARS2 VARS2 MARS2 DARS2 RARS1 SARS2 LARS1 AIMP1 AIMP2 IARS2 QARS1 WARS1 WARS2 MARS1 DARS1 SARS1 EEF1E1 PARS2 KARS1 EARS2 LARS2 EPRS1 IARS1 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 FARSA FARSB FARS2 GARS1 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions CNTNAP1 CNTN1 NRCAM ANK1 SDCBP NFASC DCX TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 HMMR DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TPX2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED BTRC RBBP4 RBBP5 RBBP7 CDK4 H2AX H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DBT DLD DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA PAN3 PAIP1 PABPC1 PARN CNOT4 CNOT6 CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT6L CNOT11 EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 EIF4A3 PAN2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC LDLRAP1 PCCA HLCS CUBN MCCC1 AMN PCCB ACACB NUDT12 ABCD4 NADK SLC2A1 CYB5R3 PRSS3 THTPA TCN1 NMRK2 NMRK1 LMBRD1 NAXE NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MMAB MOCOS FLAD1 SLC22A13 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 QPRT SHMT2 MTRR SLC25A51 PARP10 PARP6 SLC25A19 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR CD38 GPHN PDZD11 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 DCAKD NMNAT1 COASY PPCDC SLC25A16 NUDT8 VNN2 NNMT PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 PNPO AOX1 TCN2 NAMPT CD320 SLC5A6 ACACA CBLIF MMACHC MMADHC FASN BST1 VNN1 GSTO2 SLC46A1 ABCC1 MTR SLC2A3 NAPRT PDXK GSTO1 NADK2 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L SLC5A8 MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP7 PIK3R4 FURIN DDX5 RB1 BECN1 HSPG2 VCP TMPRSS2 SDC4 SDC2 SDC3 AGRN ACE2 CHMP4C CHMP4B GPC1 CHMP4A ZCRB1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 CHMP2B CHMP2A NRP1 SDC1 CTSL VHL PIK3C3 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ILK PARVA ITGB1 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration ACO1 IDH1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes PRDX2 CYCS PRDX1 COX5B COX5A COX6C COX4I1 COX4I2 COX6A1 PRKAA1 COX6A2 PRKAA2 MT-CO1 PRKAG1 G6PD PRKAG2 PRKAG3 RPTOR COX6B2 COX6B1 COXFA4 TNRC6C MLST8 COX7A2 MOV10 RRM2B COX7A1 SLC38A9 HIGD1C AGO3 AGO4 PRKAB2 AGO1 TSC2 AGO2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC YWHAE MT-CO2 PTEN SESN3 MT-CO3 RHEB RRAGB SESN2 RRAGD LAMTOR2 AKT1 LAMTOR1 LAMTOR4 YWHAQ LAMTOR3 LAMTOR5 YWHAG GPX2 YWHAH GPI YWHAZ SFN GLS2 GLS TIGAR TP63 TXNRD1 AKT2 COX7A2L COX7B TP53 COX7C TXN COX8A COX8C AKT3 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CCNH PLK1 CCNB1 CDC25C CDK1 CDC25B FZR1 CDC25A CDK2 CDK7 MNAT1 PPP2R1B PKMYT1 PPP2R1A FOXM1 PPP2CA WEE1 HJURP PPP2CB PPP2R2A SGO1 PPME1 BORA OBI1 MIS18BP1 LCMT1 PPP2R3B TICRR XPO1 CCNB2 CCNA2 CCNA1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 F3 TFPI SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation ACD TINF2 TERF1 TERF2 POT1 TERF2IP STN1 TEN1 CTC1 PRIM2 PRIM1 POLA1 POLA2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB3 KCNN2 KCNMA1 KCNMB4 KCNN1 KCNN3 KCNN4 KCNMB1 KCNMB2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses PTPRS EPB41L3 HOMER3 NTRK3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN RTN3 LRFN3 APBA3 PTPRD APBA2 LRFN2 LRFN4 EPB41L1 LRFN1 STX1A SHARPIN LRRC4B SYT9 GRIA1 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 IL1RAPL2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 DLG1 CASK NRXN2 GRIN2A LIN7A SLITRK2 DLG2 LIN7C SLITRK1 DLG3 SLITRK4 LIN7B SLITRK6 DLG4 PDLIM5 GRIA3 NLGN4Y GRIA4 NLGN4X SYT10 SYT12 APBA1 SYT1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DBNL IL1RAPL1 PTPRF GRM1 GRM5 SLITRK3 SLITRK5 FLOT1 FLOT2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism MCCC2 BTD PC ACACA PCCA HLCS MCCC1 PCCB SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins PIAS4 NFKB2 RELA EIF2AK2 PIAS3 SUMO3 IKBKE NFKBIA UBE2I SUMO1 IKBKG TOPORS UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins HBEGF SNAP25 HSP90AA1 FURIN SYT1 CD9 HSP90AB1 SV2C SV2B SV2A TXNRD1 VAMP1 MAP2K4 STX1A VAMP2 MAP2K7 EEF2 STX1B GUCY2C SYT2 NHERF4 MAP2K1 MAP2K2 CALM1 PDCD6IP DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 NEU1 ALG14 ALG2 ALG3 B4GALT1 ALG13 ALG12 MAN1B1 ALG11 ALG1 MPDU1 DPAGT1 CTSA RFT1 MGAT2 MOGS GLB1 ALG8 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis CSPG4 HSPG2 SDC4 SDC2 SDC3 B3GAT3 XYLT2 AGRN XYLT1 B3GALT6 B4GALT7 GPC1 FAM20B UXS1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 PXYLP1 B3GAT2 B3GAT1 BGN DCN BCAN VCAN SDC1 CSPG5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed SENP5 SUMO3 SENP1 SUMO2 SENP2 SUMO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C8G C5 C6 C7 CLU C9 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism SLC26A2 SLC26A11 SLC26A1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 GNS HAS2 SPAM1 B4GALT6 B4GALT5 B3GALT6 B4GALT7 IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB SLC35B3 B4GAT1 SLC35B2 XYLT2 SLC35D2 XYLT1 FAM20B CHPF PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 B3GNT3 CHST14 HSPG2 PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 ACAN SDC2 SDC3 LUM HS6ST1 B3GAT3 HS6ST2 SGSH CD44 HS2ST1 HS6ST3 NDST2 AGRN NDST1 FMOD EXTL2 NAGLU B4GALT1 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DSEL DSE UST CHST15 ABCC5 ST3GAL4 SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 HMMR ST3GAL2 ST3GAL3 SLC9A1 CTSL CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer HBEGF RAC2 RHOG NTRK3 PIK3R2 NTF3 PIK3R1 PDGFB FGF20 FGF23 MET FGF22 PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 ESR1 ESR2 SRC NRG1 CD28 PIK3AP1 CD86 CD80 ERBB2 EGF PIK3CG EGFR TRAT1 PIK3R6 PIK3R5 KLB FLT3 IRS1 IRS2 PIK3CB STRN FGF1 FGF2 FGF3 PIK3CD AREG FGF4 FGF6 FGF7 FGF9 PDGFRA RAC1 LCK FYN PDGFRB NTF4 NTRK2 BDNF KIT TGFA GAB1 FLT3LG FRS2 HGF GAB2 EREG NRG3 PIK3CA PIK3R3 NRG4 NRG2 VAV1 BTC EPGN NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM SAMHD1 PNP ITPA NT5E ENTPD1 ENTPD5 ENTPD2 ENTPD3 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP3 CHMP6 CHMP7 UBA52 STAM STAM2 HGS VPS36 VPS25 UBB SNF8 UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer SOS1 UBC HBEGF RPS27A HSP90AA1 SHC1 AREG EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN UBB SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE TLR3 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport CYGB MB NGB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses GJA10 PANX1 PANX2 GJD2 GJC1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX ANAPC16 ANAPC7 UBE2C CSF1R VENTX UBE2E1 UBE2D1 RELA ANAPC10 ANAPC11 TCF7L2 CDC23 NFKB1 UBE2S CDC26 CDC27 CDKN2A LEF1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 CCND1 ANAPC2 CTNNB1 CEBPB EHMT2 EHMT1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B IL6 TP53 ANAPC15 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 FGF18 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FGF16 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport TRAPPC6A TRAPPC6B PREB SEC22A SEC22C STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 CTSZ NSF CTSC COL7A1 SAR1B SEC31A TRAPPC4 TMED10 SEC22B TMED2 SERPINA1 SEC23A GRIA1 CD59 F5 TFG F8 SEC24B SEC24A STX5 USO1 ANKRD28 SEC13 PPP6C PPP6R3 NAPA NAPB SEC24D RAB1A SEC24C RAB1B TRAPPC1 GOLGA2 NAPG CSNK1D GORASP1 AREG TRAPPC2L LMAN1L GOSR2 LMAN1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 TGFA SEC16A TRAPPC5 TRAPPC9 YKT6 CNIH1 CNIH2 SCFD1 CNIH3 MCFD2 PPP6R1 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME CYP2E1 ABCG2 GSTT1 GSTM1 ABCC2 GGT5 NAT1 GGT7 NAT2 SULT1A1 GGT6 ABCC5 CNDP2 SULT1E1 SULT1A4 ABCC3 GGT3P UGT1A10 GGT1 ABCC1 SULT1C4 ACY1 SULT2A1 GSTP1 ABCC4 SULT1A3 UGT1A6 UGT1A1 UGT2B15 UGT1A9 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling CSF3 STX4 TYK2 TXLNA CSF1R SNAP25 STX1A IFNLR1 STXBP2 VAMP2 IL34 IL16 PRTN3 IFNL1 SDC1 JAK1 PTPRZ1 IL32 CD4 STX3 IL10RB CSF3R CSF1 CASP3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 INS KIF5C SLC30A8 PCSK1 SLC30A5 STX1A KIF5B KIF5A MYO5A RAB27A VAMP2 MYRIP P4HB PCSK2 ERO1B EXOC8 CLTRN EXOC7 CPE DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 SPAM1 ZP1 B4GALT1 ZP3 ADAM21 ZP2 ADAM20 ZP4 OVGP1 ADAM30 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2E1 PTGR1 ALOX5AP CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions RPS6KA1 CLTC CLTA AP2A1 ITGA1 AP2A2 AP2M1 CNTN1 AP2S1 KIF4B AP2B1 KIF4A NCAN RPS6KA6 LAMA1 EGFR LAMB1 LAMC1 SPTAN1 NUMB SDCBP NFASC RAC1 NRP1 MAP2K1 MAP2K2 EZR ITGB3 ITGA2B SPTBN1 ITGB1 L1CAM VAV2 DPYSL2 ITGAV NCAM1 ITGA5 ITGA9 ALCAM SCN11A RDX SCN10A MAPK1 CHL1 ITGA2 LYPLA2 DNM1 DNM2 MAPK3 CNTNAP1 SPTB RPS6KA4 SCN1B SCN1A ANK2 ANK3 SHTN1 DNM3 SPTBN4 DLG1 SPTBN5 SCN3B DLG3 SCN3A SPTBN2 DLG4 CD24 SCN2A SCN2B KCNQ2 KCNQ3 SCN9A EPHB2 SCN8A ITGA10 SPTA1 CNTN6 RANBP9 SCN5A GAP43 DCX SCN4A SCN4B MSN NRP2 SCN7A CNTN2 NRCAM ANK1 SH3GL2 HSPA8 CSNK2A1 CSNK2A2 PAK1 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 PRKACA SLC8A1 SLC8A2 NOS1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D FXYD4 FXYD3 CAMK2A FXYD2 DMPK FXYD1 FXYD7 FXYD6 ATP2B4 RYR1 ATP2B3 RYR2 ATP2B2 RYR3 ATP2B1 TRPC1 SLC8A3 CLIC2 CALM1 CAMK2G TRDN ASPH ATP1A4 ATP1A3 ATP1A2 TNNI3 ATP1A1 PLN FKBP1B AHCYL1 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 OGG1 NEIL2 POLB LIG3 NEIL1 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation GP5 GP9 F9 GP1BA GP1BB F11 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PRKCA GFRA1 SOS1 GFRA3 GFRA2 SHC1 GFRA4 MAPK7 PIK3R2 PIK3R1 NRTN PLCG1 DOK2 DOK4 DOK5 DOK6 RAP1GAP PRKACG PRKACA PSPN PRKACB GDNF RET PTPN11 IRS2 PIK3CB PDLIM7 PIK3CD DOK1 GRB10 SHANK3 SHC3 GAB1 FRS2 GRB7 GAB2 PIK3R3 PIK3CA ARTN G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG GIP PRKACA PRKACB ADRB2 PTGIR AVPR2 GNAZ LHB PDE1B ADORA2B GNG3 PDE1A GNG2 RXFP1 GNG5 RXFP2 GNG4 GNG7 PDE11A GNG8 PDE2A ARRB1 ARRB2 PTH1R GPR39 PDE10A PTH2R GPHA2 GNAS NPSR1 CRH NPS GPHB5 LHCGR RLN2 RLN3 P2RY11 GCGR GCG INSL3 GPR84 PTH2 CRHR1 CYSLTR2 RAMP2 CALCA MC1R RAMP3 CALCB PDE3B MC4R CALCR CALCRL GPBAR1 MC3R ADM2 ADM IAPP FSHR GRK5 RAMP1 PTH MC5R PRKAR1B PRKAR2B PRKAR1A PRKAR2A ADRB1 HTR4 ITGB1 GPER1 HTR6 TAAR3P ITGA5 HTR7 CGA HRH2 DRD1 DRD5 PTHLH TAAR8 TSHR TAAR9 TAAR6 GNAT3 TAAR5 TAAR2 FSHB TAAR1 ADRB3 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PDE3A PDE8B PTGER4 PDE8A GRK3 GRK6 SRC ADCYAP1 PTGER2 ADCYAP1R1 PTGDR PDE4A PDE4D PDE4C GNAI3 ADORA2A GNAI1 GNAI2 PDE7B PDE7A CRHR2 TSHB POMC GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP AVP GRK2 GNG10 MC2R GNG12 GNG11 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) STAT5A STAT5B UBE2D1 SHC1 LYN STAT3 GRB2 UBA52 JAK2 JAK1 STAT1 KRAS SOCS1 UBB PTPN11 CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC GAB2 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNQ1 KCNE5 AKAP9 KCNH2 KCNE1 KCNA5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 FGF6 FGF9 PLCG1 FGF20 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 PPP2CA PPP2CB CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C AKT2 CTLA4 YES1 LCK FYN AKT1 PTPN11 PPP2R1B PPP2R1A PPP2R5E AKT3 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels STIM1 P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 P2RX4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling FGF2 TGFBR3 GIPC1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB ENSA MASTL PPP2R2D CCNB1 PPP2R1B CDK1 PPP2R1A ARPP19 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 SFTPD IL17RC IL17RA NLRP12 YWHAQ IL17F IL17A YWHAG GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 STAT2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E IKBKB YWHAB TRIM25 IKBKE AKT1 IRF7 NUP214 SFN YWHAZ IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C NUP42 NUP85 TPR NUP62 UVRAG NUP88 MAP1LC3B NUP43 RAE1 HSP90AA1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 NOD1 NOD2 AKT2 PDPK1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 TJP1 CHUK PTPN11 SIKE1 CREBBP PTPN6 IRAK2 SNRPG TAB3 TAB2 SNRPE IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria KHK MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT11 ACADL ACOT12 HADHB ACOT13 HADHA ACADVL ACADM ACSM3 ACADS PCCA ECI1 THEM4 PCCB ACSM6 THEM5 ACAD11 NDUFAB1 ACAD10 MCAT ACBD7 ACBD6 ACOT7L ACSF2 MCEE ACOT2 DBI PCTP ECHS1 DECR1 ACOT9 ACOT7 MECR ACAA2 MMAA MMUT HADH ACOT1 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 LMNB1 UBE2I TEX12 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B REC8 SYCP3 BRCA1 STAG3 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L H2BC21 SUN2 SUN1 H2AC8 H2AC6 H2AC7 H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 STAG1 H2BC11 STAG2 RAD21 ATR DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis RIPK1 TRADD TRAF2 RIPK3 CASP8 FADD MLKL DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) RELA NFATC1 MAP3K7 NFKB1 NRAS RASGRP1 NFATC2 CHUK IKBKB CARD11 MALT1 NFKBIA FKBP1A PSMD8 PSMD6 PSMD7 RASGRP3 PSMD2 REL NFKBIE PSMD3 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PPIA PSMC5 PSMC6 HRAS PRKCB SEM1 PSMC3 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB SKP1 NFKBIB PPP3R1 CUL1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2BC9 H2AZ2 H4C9 H2BC8 PIWIL2 H2BC5 TDRKH H2BC3 PIWIL1 HENMT1 H2BC1 ASZ1 MAEL MOV10L1 MYBL1 H2AC20 TDRD9 TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 DGCR8 TNRC6C TSNAX AGO3 PRKRA DICER1 AGO4 TARBP2 TSN AGO1 AGO2 TNRC6A TNRC6B POLR2A POLR2B POLR2C HSP90AA1 POLR2D POLR2E RAN POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L IPO8 ELAC2 H2AX H2AB1 H2AC19 H2BC26 ANG H2AC14 BCDIN3D H2BC12L XPO5 H2BC21 DROSHA PIWIL4 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 POU3F2 TNRC6C MOV10 AGO3 DICER1 AGO4 HDAC1 TRPM1 AGO1 AGO2 TNRC6A TNRC6B HINT1 BIRC7 BCL2A1 SIN3A PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 PLCG1 FGF20 FGF23 KLB FGF16 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs MAP1LC3B ULK1 RAB8B RAB33B RAB33A TBC1D2 RAB5B RABEP1 RAB5C TBC1D3 TBC1D7 RAB7B RABGAP1 RAB11A RAB6A ARF6 RAB4A RAB11B RAB5A RABGEF1 TBC1D10A TBC1D10B GABARAPL2 SYTL1 RAB7A RAB6B RAB35 GGA2 TBC1D24 GGA1 TBC1D25 OPTN GGA3 TSC2 RAB8A TSC1 TBC1D20 GABARAP TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 TBC1D10C CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC2A6 SLC2A7 SLC5A1 SLC2A8 SLC5A2 FGF21 SLC50A1 SLC2A4 SLC2A9 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A10 SLC2A11 SLC2A12 SLC5A10 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D GRIN1 RPS6KA6 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 RPS6KA3 RPS6KA2 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion UBC RPS27A FURIN VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A PPIA VPS37B MVB12B MVB12A UBAP1 NMT2 UBB PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG CETP APOA2 APOA1 APOA4 APOA5 APOE ANGPTL8 ANGPTL4 LPA MTTP LPL LMF2 LMF1 APOF GPIHBP1 FGF21 MBTPS1 APOC3 APOC2 ANGPTL3 ALB P4HB ABCG1 MBTPS2 APOB PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL PPP2CA PPP2CB PECAM1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PTPN6 MAPK14 LRP8 APOB PLA2G4A PTPN11 PPP2R1B FGR PPP2R1A PPP2R5E BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 ABCA3 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases RNF128 APC OTUD5 UBE2D1 TRAF3 ZRANB1 TRAF6 UBA52 OTUB1 RHOA CDK1 OTUB2 OTUD7A OTUD7B VCP IFIH1 NOD1 TRIM4 NOD2 VCPIP1 IKBKG UBB RIPK2 RIPK1 UBC RPS27A ESR1 TNIP1 MAVS TNIP2 TNIP3 OTUD3 RNF135 RIGI PTEN TNFAIP3 TP53 TRIM25 YOD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CYP51A1 SREBF2 MSMO1 NSDHL HSD17B7 TM7SF2 SREBF1 DHCR24 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome RELA NFKB1 HSP90AB1 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 PYCARD NLRP3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 PIP4K2C IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport ATP6V0D1 FTH1 ATP6V0C ATP6V0D2 ATP6V1B1 FTL ATP6V1A IREB2 ABCG2 CP FBXL5 ATP6V0A2 CYBRD1 ATP6V1H ACO1 ATP6V0A4 SLC40A1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HEPH ATP6V1F ATP6V1C2 ATP6V0A1 TF SLC46A1 STEAP3 HMOX1 HMOX2 SLC22A17 FTMT MCOLN1 STEAP4 TFRC HFE GLRX3 UBA52 UBB TCIRG1 CAND1 UBC LCN2 RPS27A NEDD8 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 SKP1 TFR2 ATP6V1B2 SLC11A2 CUL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 CRK PXN ARHGAP35 RASA1 NRAS RHOA ELMO1 RAC1 HRAS BCAR1 ELMO2 DOCK1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling CCND1 RUNX3 CTNNB1 TCF7L2 TCF7L1 MYC LEF1 TCF7 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 GRAP2 RICTOR MAP3K8 PPP2R1B PPP2R1A PIK3CB CDC42 PPP2CA PPP2CB MLST8 PIK3CD AKT2 CTLA4 MAP3K14 YES1 PAK1 PAK3 MTOR RAC1 LCK CD28 FYN PRR5 PDPK1 PAK2 AKT1 PIK3R3 PIK3CA VAV1 MAPKAP1 PPP2R5E AKT3 TRIB3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA RPS6KA1 SOS1 CCKBR HBEGF MAPK7 EGFR NRAS MAPK1 HRAS MMP3 MAPK3 GAST RPS6KA3 RPS6KA2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants FZD5 FZD4 WNT3A FZD6 LRP5 RNF43 FZD8 LRP6 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle LIG1 BANF1 XRCC6 FEN1 XRCC4 KPNA1 XRCC5 LIG4 PPIA HMGA1 CCR5 CXCR4 PSIP1 CD4 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E UBC RPS27A UBA52 UBB MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling RANBP10 HRAS SOS1 MUC20 MET RANBP9 HGF NRAS CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA1 NRAS MAPK1 MAPK3 RASGRF2 CAMK2B CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 RPS6KA6 PDPK1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RPS6KA3 CALM1 CAMK2G RPS6KA2 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX10 PPOX ALAS1 CPOX HMBS ABCG2 ALB UROD UROS ALAS2 COX15 ALAD FECH ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase CREBBP HSP90AA1 HSPA8 EP300 HSP90AB1 DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A FKBP4 HSPA1B SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins SOS1 STAT5A STAT5B CDKN1A PIK3R1 NRAS TRIP11 GOLGB1 PIM1 HRAS ZMYM2 GAB2 MYO18A PIK3CA ETV6 NOX4 SPTBN1 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH GNMT DAO PXMP2 GLDC AGXT HOGA1 GOT2 KGD4 GRHPR DDO HAO1 AGXT2 AMT DLST ALDH4A1 PRODH2 DLD FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate POU3F1 PAX6 ZIC2 ZEB2 SOX2 POU5F1 NANOG ZNF521 SOX1 GBX2 OTX2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN RNF146 PSMA5 PSMA6 PSMA3 PSMA4 AXIN2 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 TNKS PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A SMURF2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 AXIN1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT5 NUDT16 NUDT15 ADPRM NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling RGMB RGMA UNC5A UNC5B PLCG1 SIAH2 UNC5C UNC5D PITPNA AGAP2 WASL HJV SIAH1 PTPN11 CDC42 SLIT1 SLIT3 NEO1 DSCAM NTN4 MYO10 DCC DSCAML1 NTN1 TRIO NCK1 SLIT2 ROBO1 SRC RAC1 TRPC7 TRPC5 TRPC6 PRKCQ ABLIM1 TRPC3 ABLIM2 TRPC4 ABLIM3 TRPC1 PTK2 EZR DOCK1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A SS18 SMARCB1 SMARCD1 DPF1 BCL7A DPF2 BCL7C SMARCA2 BCL7B DPF3 SMARCA4 SMARCC1 SS18L1 ARID1A SMARCE1 ARID1B ACTB SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane SRPRB SEC61A2 SEC61A1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TRAM1 RPS3A RPS26 SRP54 RPS25 RPS28 SSR4 RPS29 SSR2 RPS20 SSR3 SRP9 FAU RPS21 RPS24 RPS27 RPS23 SRP72 SRP68 SRP19 RPN2 RPN1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL DDOST RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 SRP14 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 SEC61G RPLP0 SEC61B RPS27A SSR1 SRPRA SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A2 SLC17A1 SLC26A11 SLC4A7 SLC26A1 SLC20A2 SLC4A8 SLC4A10 SLC4A9 SLC26A4 SLC26A7 SLC26A3 SLC26A9 SLC26A6 SLC13A1 SLC13A4 AHCYL2 SLC12A3 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC4A2 SLC12A7 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 SLC12A6 SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC5A5 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin MAOA SLC6A4 ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME MAPDA NT5C2 ABCB1 ADH1A PCK1 ABCG2 SLC22A2 SLC22A3 SLC22A1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism CDA ADSL PPAT GMPS NUDT13 ADSS1 ADSS2 GART PAICS PFAS NT5C DCTPP1 AGXT2 NT5C1A DPYS NME2 DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP RRM1 RRM2B SAMHD1 DTYMK ATIC ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 TK1 ENTPD8 AK1 RRM2 AK2 NME1 AK4 AK5 AK6 AK7 AK8 AK9 GLRX NME3 NME4 DCTD CMPK1 TXNRD1 TYMS CTPS2 MAPDA CTPS1 GMPR2 GDA ADK AMPD1 NT5C2 NUDT5 GMPR DNPH1 AMPD2 AMPD3 NT5C1B NUDT16 DCK NUDT15 APRT ADPRM DGUOK PNP ITPA HPRT1 IMPDH1 IMPDH2 ADA UCKL1 UCK2 UCK1 PUDP TK2 NT5E ENTPD1 ENTPD5 TXN CAD DHODH UMPS GUK1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 STX1A SYT1 VAMP2 SV2C SV2B SV2A VAMP1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival IKBKB SQSTM1 UBC RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR UBB HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 MFN1 MFN2 KLC1 KLC4 IFNA10 KLC3 GUCY1B2 KLC2 GUCY1B1 IFNA21 ATP2A3 ATP2A2 IFNB1 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PLA2G4A FGR STIM1 KCNMA1 ORAI2 SLC16A8 PECAM1 ORAI1 SLC16A3 PDE9A PDE1B PDE1A KIF5B ITPR1 KIF5A ITPR2 SLC16A1 ITPR3 SRI PSAP LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS2 NOS3 PDE2A ATP2B4 VPS45 ATP2B3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 P2RX4 PDE10A P2RX3 CRK P2RX2 P2RX1 GNAS SERPINB8 S100A10 C1QBP CABLES1 RAB5A MMP1 SLC3A2 SLC7A11 EPCAM SLC7A10 PRKCB SERPINC1 RAC1 VAV3 SERPIND1 PRKCQ SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 VAV2 SLC7A9 IRF1 IRF2 NFE2 V2-11 V3-4 V3-3 MPL V2-17 THPO V3-2 V2-15 V2-19 V1-11 GNA13 V1-16 V1-13 CAPZA2 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 TBXA2R V4-6 V4-2 V4-1 SDC1 GATA3 LYN INPP5D PIK3CG PIK3R6 PIK3R5 CFL1 PF4 SERPINB2 ANXA2 MIF SOD1 CAPZA1 AAMP PPIA TUBA4A PRKCG TP53 PRKCE GNG10 GNG12 GNG11 GNG13 ITGA3 GNB2 GNAQ ITGA1 GNB1 MAFG ITGA6 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 WEE1 GNA14 OLR1 SPN VPREB3 VPREB1 GNG3 CXADR CDK5 GNA15 PSG1 PDPN PSG3 MPIG6B GNG2 SERPINB6 CLEC1B PSG2 GNG5 PSG9 GNG4 FCAMR GNG7 PSG8 GNA11 PSG5 GNG8 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 ARRB1 ARRB2 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD SH2B2 ANGPT4 ANGPT2 MERTK CD2 CD244 ITGAM ITGB2 PPP2R1B PPP2R1A PIK3CB CAPZB PRCP PFN1 GATA6 TFPI F13B HRAS PCDH7 ZFPM1 PDPK1 RBSN SIRPG GRB7 KIF18A PIK3CA PIK3R3 ITGB1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 NRAS GP1BA RHOA HBB RHOB KIF2A MAPK1 KIF2C KIF2B FCER1G CEACAM3 MAPK3 PTPN1 PTPN11 CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA PPP2CB CD58 ITPK1 CENPE DGKG SRC DOCK5 DGKE ACTN2 DOCK4 DAGLA DGKD DOCK3 DGKB DGKA ABHD6 ABHD12 PLAU PRKCH DGKZ SIRPA DGKQ DAGLB DGKK DGKI DGKH CALM1 DOCK2 DOCK1 VEGFB VEGFC VEGFD THBS1 VEGFA SELL GNA12 CSK JAK2 FGB FGA VWF PLAUR FGG APBB1IP TLN1 VCL CEACAM1 SYK RAD51B LCK FYN F7 APP F9 F13A1 RAD51C POTEKP PROC ISLR F10 LAMP2 PROS1 HABP4 FAM3C CHID1 F2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 KIF28P TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 KIF5C PDGFB A1BG CLU KNG1 KIF21A CYB5R1 KIF21B RASGRP2 KIFAP3 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A PRKACG RARRES2 IGF2 RAF1 IGHV3-23 PRKACA RAB27B PRKACB IGF1 RAPGEF3 PPBP IGLV CYRIB RAPGEF4 IGLV2-8 MANF SELP IGKV1-16 TF KIF16B IGKV1-17 SCCPDH IGKV1-12 KIF20B CALU IGHV3-7 MAGED2 IGHV3-9 HRG IGHV3-30 FERMT3 LGALS3BP IGHV3-33 SERPINA3 KIF3B IGKV1D-39 A2M ORM1 IGKV1D-33 ECM1 SERPINA1 KIF3C WDR1 IGKV2D-28 PLEK IGKV4-1 OLA1 KIF18B IGHV7-81 CTSW KIF4B ORM2 SERPINA4 IGKV2D-30 KIF4A TMSB4X IGHV4-59 ALB IGHV1-69 PHACTR2 KIF12 TIMP3 PHF21A KIF11 QSOX1 PRTN3 TIMP1 IGLV2-11 SRGN IGLV1-40 CAP1 IGLV1-47 TRPC7 KIF15 ABCC4 AHSG KIF19 IGLV6-57 ANXA5 IGLV2-14 F5 IGLV1-44 TRPC6 KIF13B PLCG2 F8 TRPC3 KIF1C IGKV3-15 MMRN1 KIF1B TOR4A IGKV3-11 IGKV2D-40 CD63 IGHV3-11 ITIH4 KIF1A IGHV3-13 ITIH3 PLG IGLV7-43 IGKV1D-16 TTN IGKV1D-12 CLEC3B KIF25 IGLV1-51 CDC37L1 SPP2 IGLV2-23 KIF22 STX4 RCOR1 KIF6 LEFTY2 IGKV3-20 IGHM KIF27 LY6G6F LHFPL2 PCYOX1L IGHV4-34 IGHV1-2 KIF9 CD9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 FLNA IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 HMG20B PPIL2 IGLC1 IGLC2 F2RL2 ADAMTS13 F2RL3 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 F2R IGKC LAT IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 KIF26A IGLC6 IGKV1-5 KIF26B PRKAR1B PRKAR2B PRKAR1A PRKAR2A P2RY12 P2RY1 HDAC1 ACTN1 SIN3A CDK2 ADRA2C ADRA2B F3 ADRA2A SH2B3 AKT1 SERPINE2 GATA4 JMJD1C GP1BB GATA1 F12 HBE1 PRKCD F11 ZFPM2 PRKCA GATA5 GP5 SERPINA5 AK3 YWHAZ GP9 MICAL1 KLKB1 CARMIL1 HBG2 HBG1 EHD1 EHD2 EHD3 MAFF HBD AKAP10 DOCK10 DOK2 AKAP1 SH2B1 CABLES2 GP6 ITGA10 MAPK14 RACGAP1 CAV1 CFD JAM2 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 KIF3A PDE5A DOCK11 EGF PLCG1 DOCK6 DOCK9 DOCK8 DOCK7 PLAT MYB H3-3B F11R H3C8 PRKCZ KIF23 BCAR1 KIF20A ITGB3 ITGA2B GATA2 L1CAM H3C15 ITGAV ITGA5 BRPF3 TNFRSF10B SPARC TNFRSF10A SERPINE1 TNFRSF10D ITGAX KDM1A GNAT3 ITGA2 ITGAL TGFB2 TGFB3 ITGA4 TSPAN7 MGLL HDAC2 PICK1 GNAI3 GNAI1 CBX5 GNAI2 CD36 ALDOA TREM1 MAFK PTPN6 YES1 BSG IGHA1 PTK2 IGHA2 IFNA5 IFNA4 IFNA7 JCHAIN IFNA6 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress JUN CCAR2 DNAJC2 DNAJC7 CXXC1 COX5B RPS19BP1 HSPA4L COX5A HSPA14 RELA HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 COX6C HSPA7 HSPA12A HSPA12B IFNB1 COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM IL6 APOB YWHAE GSK3A CDKN2D EED CDKN2C PDIA6 DNAJB11 CAT IGFBP7 WFS1 SOD2 CARM1 IL1A FBXL17 BACH1 PRKCI TLR4 DNAJC3 SLC7A11 LY96 MED1 OMA1 PRDX2 PRDX1 MAPK7 ADD1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 ATF6 DNAJA4 CRYAB DNAJA2 MAP3K5 CAPZA2 FKBP4 DELE1 HERPUD1 ACTR10 HSPA1B MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 SQSTM1 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 UBE2D2 UBE2D3 HIF3A KEAP1 LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 AR EGLN2 WTIP CDKN2B NPLOC4 NRF1 RPLP0 UBXN7 DPP3 HSPA9 UFD1 TALDO1 SOD1 CAPZA1 CSNK2A1 FKBP14 IGFBP1 GPX1 GOSR2 CSNK2A2 MYDGF EXTL1 TATDN2 LMNA SSR1 CSNK2B DNAJB9 SULT1A3 TSPYL2 ZBTB17 TP53 KLHDC3 DDX11 WIPI1 PGR YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB FKBP5 TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP MAP2K6 PRDX6 NLRP3 ESR1 CLEC1B MDM2 MDM4 GSTP1 NUP205 POM121 HMOX2 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 SMARCD3 NUP133 NUP210 HMGA1 NUP153 NUP93 HDAC6 NUP50 NUP35 RBBP4 NUP54 NUP37 RBBP7 STIP1 TXNRD1 TCIRG1 DYNC1LI1 CAPZB DYNC1LI2 AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 COX7A2L TXN RPS27 ATP6V1B2 EPO TRIB3 ATP6V0D1 CITED2 ATP6V0C ATP6V0D2 VENTX PPP2R5B ATP6V1B1 ATP6V1A SHC1 DYNLL1 ABCG2 DYNLL2 HBB ATP6V1H MAPK1 ATP6V0E2 NFYA ATP6V1G3 NFYB NFYC ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 DYNC1I2 BMAL1 MAPK3 COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A HM13 EIF2AK3 NOX4 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 HSPA6 UBE2D1 HSPE1 ANAPC10 HSPD1 ANAPC11 VEGFA CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN TLN1 RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 SKP1 CCNA2 ATM CCNA1 ATR CUL1 CXCL8 CREB3L3 NUDT2 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 HSPA5 HSBP1 CHD6 GPX3 HSF1 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 DEFA5 BTRC RPS4Y2 RPS27L RPS4Y1 ATOX1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A STOML2 RPS16 GCN1 WDR59 RPS19 PHB2 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT YME1L1 RPS10 DEPDC5 RPS13 KPTN WDR24 RPS12 RPS9 SH3BP4 RPS7 FNIP1 RPS8 FNIP2 RPS5 KICS2 CASTOR1 RPS6 CASTOR2 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 CDKN1A CDKN2A HSP90AB1 SIN3A CDK2 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS PRKAA2 SEC31A EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 RPTOR ATF3 ATF4 TNRC6C CALR MOV10 MLST8 SLC38A9 ID1 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 TXNIP HMOX1 RRAGC MT-CO2 PSMD7 MT-CO3 RHEB RRAGB XPO1 PSMD2 RRAGD KHSRP AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 NUP214 LAMTOR5 DIS3 IDH1 PRKCD NCF1 PSMA5 NCF2 PPARGC1A PSMA6 NCF4 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 ACTR1A DCP2 SERP1 PSMD12 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 CYBB PSMB4 EXOSC5 CYBA PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 CUL7 HSPA8 DCTN2 ADRM1 DCTN3 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PGRMC2 PSMC4 PSMC1 PSMC2 SIRT1 HSPA1A SIRT3 PPARA CYCS HMGA2 H1-1 H1-0 H1-3 CUL3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A TRIM21 HSPH1 HYOU1 HBA2 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 HIGD1A H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 HSP90B1 KDM6B H3C15 RXRA ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 STAT3 H3-4 H2BC1 POT1 NFKB1 TERF2IP H2AC20 RPL4 RPL5 HDAC3 RPL30 RPL3 RPL32 RPL31 RPLP1 NRIP1 RPL34 RPL10L COX4I1 RPL8 COX4I2 RPL10A TBL1X RPL6 RPL7 NCOA1 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 NCOR2 ARNT RPL39 RPL21 RPL23 NCOR1 RPL22 BMI1 TBL1XR1 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RNF2 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 CRTC2 CRTC3 CRTC1 CLOCK MAP2K3 NPAS2 HELZ2 MAP2K4 RAI1 CREBBP MAPKAPK3 SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 TGS1 MEF2D MAP2K7 MAPK10 COX7B FOS GFPT1 FOXO3 COX7C EDEM1 SYVN1 COX8A COX8C AKT3 HIKESHI KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB MECR HADHA ECHS1 ACADM HADH SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs NTRK1 KIDINS220 SOS1 CRK SHC1 NGF MAPKAPK2 NRAS RALA MAPK1 RAP1A MAPK3 BRAF RAPGEF1 MAPKAPK3 MAPK14 MAPK11 YWHAB SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 FRS2 RIT1 MAP2K1 RIT2 CRKL MAP2K2 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection SNRNP200 HDLBP SRSF6 KDELR1 SRSF7 AP2A1 SNRPB AP2A2 SRSF9 DDX5 BAG2 PRPF8 AP2M1 CLU CPSF4 CPSF1 APOA1 HSPA5 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 PRKG2 CD209 RTN3 CHERP ISY1 AP2S1 DDX46 DDX42 YBX1 PTBP1 AP2B1 HAVCR1 BCAS2 P4HB RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 IPO7 PUF60 DNAJB11 U2AF2 P4HA1 P4HA2 SNRPB2 CD14 P4HA3 SMNDC1 DNAJC10 NMT1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 KPNB1 PPIL3 PPIL4 TLR4 DNAJC3 HNRNPA1 STAT2 LY96 RPSA MAPKAP1 PDCD6IP FASN C4BPA C4BPB RPN2 TUSC3 ATG14 RPN1 HSP90AB1 MAGT1 CTNNB1 DNAJA2 C4B_2 OST4 SDC4 ATG7 HSPA1B SDC2 DDOST SDC3 TMEM258 RPTOR DAD1 OSTC CALR CANX ACOT2 MLST8 STT3A STT3B EIF4E GPC1 GPC3 UBE2I GPC2 MRC1 GPC5 SUMO1 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 XPO1 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D XRN1 LYN POLR2E POLR2F POLR2G PABPC1 POLR2H UBA52 POLR2I POLR2J NPLOC4 POLR2K POLR2L H2AC25 NEK2 H2AC21 PDIA3 GTF2F1 CLDN1 GTF2F2 IFIH1 UFD1 UBB UBC RPS27A HSPA8 UBA7 UBA6 UBA5 UBR4 NRBP1 HSPA1A KPNA2 EIF4G1 PEX19 RNASEK ATL2 LY6E KPNA7 NACA KPNA4 HNRNPA0 TIMD4 KPNA5 CD2BP2 KPNA3 HNRNPUL1 TYRO3 BTF3 FURIN AUP1 UBA3 PPIL6 MAPRE3 EMC4 UBA1 ELAVL2 RICTOR H2AC1 CPSF7 SPCS3 SRRM1 SPCS2 VCP CLINT1 SPCS1 SEC11A SEC11C VIM HNRNPC RIPK1 RBMX STING1 NFKBIA SCAP MAVS HYOU1 CLEC5A MAP1LC3B HSP90AA1 KPNA1 H2BC18 MERTK BECN1 DAXX EIF4E3 H2AC19 AXL H2BC26 H2AC14 EIF4G3 EIF4G2 H2BC21 SUN2 TSG101 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 PIK3R1 CDC40 H2AC20 DHX9 HSPG2 CD33 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 CD300A HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 DPM1 SF3A1 DPM2 SF3A2 DPM3 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 RRBP1 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN NCL WBP11 PRPF6 SNRPG SRSF2 PROS1 PPIE NFKBIB SRSF3 F2 SNRPE GAS6 SRSF4 SNRPF SRSF5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases MMP15 COL18A1 MMP17 KLKB1 FURIN CMA1 ELANE CTSG PRSS2 MMP8 MMP9 KLK2 MMP25 MMP1 TIMP2 MMP2 PRSS1 CTRB2 SPOCK3 CTRB1 TIMP1 MMP3 CTSV MMP24 TPSAB1 MMP7 MMP13 CTSK MMP10 PLG MMP11 MMP14 MMP16 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling SOS1 CRK SHC1 FN1 RASGRP2 RASGRP1 RAP1B RAP1A CSK FGB RAPGEF3 FGA RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 AKT1 PTK2 ITGB3 ITGA2B METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY CBS MAT1A NNMT GNMT CTH SCLY HNMT SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport SLC10A6 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C CAMK4 GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL CALM1 CAMK2G ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D GNS CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CYSLTR1 CCL2 EDNRA OPN3 CCL1 RRH EDNRB CCL19 PTGIR PROK2 CCR2 RGR CCL17 AVPR2 PROK1 AVPR1A CCL16 OPN5 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 LPAR4 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 GPR17 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP LPAR6 CMKLR1 NMS PDYN NMU AGTR2 GNRH2 FPR3 GNRH1 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 GPR132 CCKAR GNRHR GPR183 FFAR4 PNOC FFAR3 GPR18 FFAR2 SSTR3 GPR39 EDN1 GPR37 ANXA1 EDN2 GPR35 EDN3 GPR31 CCKBR GPHA2 NPSR1 GRP GPR55 PTAFR NPS GPHB5 PLPPR1 PROKR1 LHCGR PLPPR2 PROKR2 MTNR1A PLPPR3 KISS1R MTNR1B MCHR1 PLPPR4 P2RY10 RLN2 PLPPR5 P2RY11 RLN3 LPAR1 ECE1 LPAR2 GPR4 ECE2 LPAR3 PRLHR LPAR5 MT-RNR2 INSL3 F2RL1 CHRM2 INSL5 S1PR1 PENK F2RL2 CHRM3 S1PR3 F2RL3 CHRM1 S1PR2 APLN GPR37L1 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 KEL PMCH NLN CYSLTR2 PPY MC1R GHSR MC4R OXGR1 F2R GPBAR1 LTB4R2 MC3R UTS2 GAL NTS FSHR MCHR2 NPB OPN4 NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R LTB4R NPY1R APLNR SUCNR1 BDKRB2 HCAR2 BDKRB1 HCAR3 QRFPR GNRHR2 HCAR1 XCL2 XCL1 PYY HTR2B HTR2C HEBP1 ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 ADORA3 ADRA1A CCK ADORA1 HRH1 GPER1 HCRTR2 HTR6 HCRTR1 TAAR3P NPY5R KISS1 HTR7 SSTR1 CGA HRH3 SSTR2 HRH2 HRH4 SSTR4 DRD1 SSTR5 DRD2 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 DRD5 HTR1E CNR2 TAAR8 CNR1 HTR1F TSHR TAAR9 OPRD1 ACKR1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 FSHB ADRA2C C5AR2 HTR5A ADRA2B TAAR1 C5AR1 ADRA2A GPR143 C5 ADRB3 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR ADORA2A AGT TSHB PF4 C3 FPR1 FFAR1 ADRB2 OPN1LW LHB ADORA2B OXER1 OPN1MW RHO NPY CXCR1 CXCR2 OPRM1 SST OPN1SW OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis MUC15 MUC13 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC3 MUC1 ST6GALNAC4 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 MUC12 ST6GAL1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX F9 F10 F8 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria BID CASP8 GZMB NMT1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling RPTOR EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B YWHAB RPS6 MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation KPNA1 H1-1 H1-0 DFFB H1-3 DFFA HMGB2 HMGB1 H1-2 H1-5 H1-4 KPNB1 CASP3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) PCNA POLH MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR FIGNL1 UBA52 FIRRM BLM MRE11 RTEL1 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 RFC5 UBC RMI2 POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE RMI1 POLD2 RFC2 RFC1 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C POLE4 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 POLE2 POLE3 ATR RAD9A RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy MAP1LC3A FUNDC1 ATG5 CSNK2B MAP1LC3B ATG12 ULK1 CSNK2A1 CSNK2A2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH12 RDH8 RBP1 LRAT STRA6 TTR RDH5 RLBP1 RDH11 ABCA4 RDH10 RDH16 SDR9C7 RPE65 RHO MYO7A DHRS9 CYP4V2 RBP3 HSD17B6 HSD17B1 RBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 HSP90AB1 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSBP1 PTGES3 HSF1 HSPA2 CRYAB VCP FKBP4 MAPK3 HSPA1B RPTOR MLST8 CAMK2B HSPB8 CAMK2D HSPH1 CAMK2A MTOR YWHAE NUP205 AKT1S1 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C CAMK2G NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 HSP90AA1 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 NUP37 HSPA9 CREBBP EP300 HSPA8 RPA1 RPA2 EEF1A1 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes NCAPH CSNK2B SMC4 SMC2 CCNB2 CCNB1 NCAPD2 CSNK2A1 CDK1 NCAPG CSNK2A2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G IQGAP1 FAM114A2 QKI KIAA1549 ESRP1 TRIM24 FXR1 FN1 AGTRAP ARAF AP3B1 PEBP1 CSK AGGF1 JAK2 TENT4A MARK3 FGB FGA VWF KSR1 FGG BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation NR1H2 CLTC PCSK9 NR1H3 UBC AP2S1 CLTA AP2A1 VLDLR RPS27A AP2A2 AP2B1 UBA52 AP2M1 MYLIP UBB DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME UGT2B7 SLCO1B1 SLCO1B3 GSTA1 ABCC2 XDH GGT5 GGT7 GGT6 CNDP2 GGT3P GGT1 SLC16A1 ALB ACY1 SLC22A3 GSTP1 ABCC4 CES1 SLC22A2 SLC22A1 CYP2C9 CYP2C8 CYP2C19 MAPDA ADK AKR1C1 PNP CYP2D6 HPRT1 SLC22A7 IMPDH1 ADA IMPDH2 SULT2A1 CES2 SLC28A2 RAC1 SLC29A1 VAV3 SLC29A3 SLC29A2 SLC28A3 VAV1 VAV2 CYP2E1 HSD11B1 ABCG2 HSD11B2 GMPS TPMT GSTT1 UGT1A3 PCK1 GSTM1 NME2 SERPINA6 SULT1A1 SULT1E1 ACSM2B SULT1A4 ABCC3 ABCC1 SULT1C4 BCHE PON3 PON1 NME1 NAT1 NAT2 SLCO1A2 ABCC5 NT5C2 ABCB1 NUDT15 ADH1A GSTA2 UGT1A10 ITPA UGT2B28 UGT1A5 UGT1A4 UGT3A2 SLC22A8 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 BSG GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A CYP3A4 ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 GUK1 UGT2B4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi MAN1C1 MAN1A2 MGAT1 MAN1A1 MANEA RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCA NCF2 NCF4 RAC2 PIK3R4 NOXA1 NOXO1 NOX3 MAPK14 PRKCZ MAPK11 NOX1 PRKCB MAPK1 RAC1 S100A9 PIN1 S100A8 CYBB CYBA MAPK3 PIK3C3 PRKCD NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 RPS27A FGF4 CBL FGF9 UBA52 FGF20 MKNK1 SPRY2 MAPK1 FGF23 FRS2 MAPK3 BRAF PTPN11 UBB FGF16 PPP2R1A KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway MAFG RELA PGD NQO1 GSTA3 MUL1 GSTA1 SESN1 SRXN1 CHD6 CUL3 VCP CCL2 ABCF2 SOD3 G6PD GCLC GCLM TRIM21 SESN2 MAP1LC3B EGF BTRC SKP2 FBXL17 BACH1 PRKCI TXNRD1 SLC7A11 EP300 AKT2 TXN NOTCH1 PRDX1 NFKB1 CDKN1A ABCG2 CDKN2A PRKAA2 SQSTM1 ATF4 TKT ABCC3 MYC ABCC1 PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 EIF2AK3 AMER1 GSK3B IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 NPLOC4 PSMD11 ME1 PSMD14 UBXN7 PSMD13 PSMA7 BRCA1 PSMB6 PSMB7 PSMB4 DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 BCL2 PSMB1 PDGFA MAFK RPS27A AREG NFE2L2 BCL2L1 ADRM1 CSNK2A1 PALB2 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 CUL1 AKT3 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CREBBP PER3 CRY2 CRY1 BMAL1 CSNK1D KMT2A CSNK1E CLOCK NPAS2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency GSS RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle TFRC VANGL1 WDR11 SLC4A7 UACA RHOH TMEM59 JUP TUBA1B ROCK1 ARHGDIB ROCK2 CSK RALGAPA1 FAM91A1 VCP NSFL1C DBN1 VAMP3 RAB7A SLC1A5 NIPSNAP2 PAK6 ARHGDIG STOM PAK1 PAK5 LCK MTR ARHGDIA PAK2 ZAP70 LAMTOR1 PAK4 OSBPL11 DBT CAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A PACS1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLCO4A1 SLC26A2 SLC22A5 SLC17A1 SLC24A2 SLC24A3 SLCO2B1 SLC41A2 SLC5A1 SLC26A11 SLC41A1 SLC5A2 SLC30A10 SLC16A2 SLC39A6 SLCO1B1 SLC39A5 SLC26A1 SLCO1B3 SLC39A8 SLC15A1 SLC39A7 SLC14A1 CTNS CP SLC39A2 SLC15A3 SLC14A2 SLC6A5 SLC39A1 SLC15A4 SLC4A10 SLC39A3 SLC2A9 SLC30A8 SLC26A4 SLC30A3 SLC26A7 SLC30A2 SLC26A3 SLC31A1 SLC26A9 SLC30A5 SLC26A6 SLC40A1 SLC39A10 SLC25A1 SLC2A1 SLC30A1 SLC2A2 SLC6A2 SLC39A14 SLC13A1 SLC6A3 SLC8B1 SLC8A1 SLC13A2 SLC22A12 SLC8A2 SLC13A3 HEPH SLC13A4 SLCO1C1 SLC2A10 SLC47A2 SLC47A1 SLC5A12 SLC5A10 SLC25A26 SLC24A4 SLC16A7 SLC16A8 EMB SLC11A1 SLC16A3 SLC13A5 FGF21 RSC1A1 AHCYL2 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 SLC24A5 SLC22A4 SLC22A3 SLC22A6 SLC45A3 SLC10A6 SLC22A15 SLC22A16 SLC22A11 SLC20A1 SLC8A3 SLC2A6 SLC2A7 SLC2A8 PDZD11 SLC50A1 SLC4A8 SLC4A9 SLC6A20 SLC35B3 SLC43A2 LCN9 SLC1A1 SLC35B2 SLC43A1 SLC27A1 SLC1A2 SLC35B4 SLC3A1 SLC35D1 SLC1A3 SLC35D2 SLC1A4 LCN15 SLC3A2 LCN12 SLC7A11 SLC7A10 SLC35A2 SLC1A6 SLC35A3 SLC33A1 SLC1A7 SLC5A6 SLC7A1 ARL2BP SLC7A3 LCN1 SLC25A29 SLC29A4 SLC38A3 SLC27A6 SLC38A2 SLC28A2 SLC36A4 SLC29A1 SLC38A5 SLC2A13 SLC28A1 SLC38A4 SLC29A3 SLC36A1 SLC5A11 SLC6A19 SLC5A3 SLC29A2 SLC28A3 SLC38A1 SLC27A4 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC5A5 SLC32A1 SLC6A13 SLC20A2 SLC6A1 SLC6A9 SLC17A6 SLCO1A2 SLC1A5 ARL2 SLC67A1 SLCO4C1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 SLC22A7 SLC12A2 RUNX1 SLC12A4 SLC6A7 SLC12A5 SLC12A7 SLC6A11 SLC25A18 SLC25A11 SLC6A4 APOD SLC17A7 SLC25A22 SLC2A3 CALM1 SLC35C1 SLC4A7 SLC25A10 SLC24A1 SLC17A5 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 AVP SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC2A4 SLC35A1 SLC22A8 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 BSG SLC5A9 SLC12A6 SLC60A2 SLC39A4 SLC34A3 SLC5A4 SLC34A2 SLC2A14 SLC34A1 SLC2A11 SLC11A2 SLC2A12 SLC5A7 SLCO2A1 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 CDK2 MLH1 FIGNL1 TEX15 MSH4 MSH5 MND1 FIRRM BLM MRE11 BRCA1 BRCA2 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 H2AC19 H2BC26 H2AC14 SPO11 H2BC12L H2BC21 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 H2BC11 ATM H3C15 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation JUN IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 HRAS VAV3 VAV1 VAV2 SOS1 V2-11 V3-4 NRAS V3-3 V2-17 IGHE V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 MAPK8 MAPK3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN MAP2K4 MAPK9 SYK PAK1 MAP2K7 MAP3K1 MAPK10 FOS PAK2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 HES5 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 TACC3 MAMLD1 PSEN1 RBPJ SMAD3 ACTA2 SNW1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 FLT4 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A HEY1 KAT2B KAT2A EP300 HEY2 JAG1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 MAML3 NOTCH2 NOTCH1 CUL1 NOTCH4 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EED UXT PCGF6 RRM2 EPC1 CDC7 E2F1 RBBP4 EZH2 BRCA1 RYBP RBBP7 TFDP1 TFDP2 CHEK1 RBBP8 YAF2 EHMT2 EHMT1 MAX BMI1 CBX3 RING1 L3MBTL2 RNF2 E2F6 SUZ12 RAD51 PHC1 CBX5 MGA PCGF2 PHC3 APAF1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 GLRX5 FDX1 FXN SLC25A28 FDX2 SLC25A37 LYRM4 FDXR HSCB RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport CYCS MT-ND6 COX5B COX5A MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 COX6C TMEM126A UQCRC2 TMEM126B TRAP1 SURF1 COX6A1 COX6A2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 COX6B2 NDUFAF2 SFXN4 COX6B1 NDUFAF3 NDUFAF1 HIGD1C HCCS TMEM186 RAB5IF OXA1L ACAD9 COQ10B COQ10A TMEM177 DMAC1 DMAC2 UQCR11 UQCR10 PET117 TIMMDC1 PET100 MDH1 MDH2 NUBPL LETM1 LYRM2 LYRM4 LYRM7 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 NDUFAB1 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 COX18 HIGD1A UQCRH COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 UQCRFS1 COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 MT-CO1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 BCS1L COXFA4 NDUFA6 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 COX19 TTC19 COX17 UQCRHL SCO2 MT-CO2 MT-CO3 CYC1 NDUFS3 GOT2 HSCB ECSIT HSPA9 TIMM21 SLC25A12 FXN SLC25A13 NDUFB8 COX7B COX7C COX8A COX8C FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm TBX6 BMP4 LEF1 MAMLD1 CTNNB1 MESP2 DLL3 HES7 MSGN1 RBPJ RIPPLY2 SNW1 EPHA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 NOG PSMD11 PSMD14 PSMD13 WNT3A PSMA7 PSMB6 FGFR1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP MAML2 PSMB1 MAML1 KAT2B KAT2A LFNG EP300 ADRM1 TBXT PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 MAML3 NOTCH1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 SEL1L MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 CP MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 RNF185 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 DERL1 MRPL45 DERL2 MRPS6 RNF5 MRPL46 MRPS5 OS9 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 ARF4 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 EXOC8 EXOC7 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 EXOC4 MRPL12 EXOC3 MRPL57 EXOC6 MRPL13 EXOC5 MRPL54 EXOC2 MRPL10 EXOC1 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 GBF1 MRPL21 MRPL22 KGD4 RAB11A MRPL30 MTRES1 MTRFR NDUFAB1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN PIAS3 DDB1 UBE2V2 COPS7B XPC COPS7A CUL4A COPS3 COPS6 COPS5 UBE2N COPS8 BDH1 OXCT1 HMGCS2 ACAT1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 CAPZA3 CAPZA2 ACTR10 SQSTM1 TFAP2B TFAP2C TWNK UBE2I SUMO1 SSBP1 EIF1AX EIF4H UBE2D2 EIF3M UBE2D3 EIF3K HIF3A EIF3L EIF3I ELOB EIF3J ELOC EIF3G RBX1 EIF3H EIF3E EPAS1 EIF3F CUL2 EIF3C HIF1A EIF3D VHL EIF3A EIF3B GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 EIF5A FBXL5 DHPS WRAP53 FN3KRP TUBA8 GNGT1 EIF5A2 TUBA1C FN3K ICMT TUBA1B GNGT2 DOHH TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 KLK13 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 NUP37 CDC20 MT-ND4L PARS2 MRTFA EARS2 LARS2 PPA2 DYNC1LI1 PPA1 TARS2 DYNC1LI2 TARS1 AARS1 AARS2 HARS1 HARS2 CDCA8 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 TCF25 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 DYNLL1 CARS2 VARS2 RANGAP1 ANKZF1 KLHDC10 DYNLL2 TSFM EIF5B RHOA MARS2 DARS2 INCENP EEF1G BIRC5 SARS2 NEMF EEF1D MTRF1L EEF1A1P5 MTIF2 PRMT3 MTIF3 DYNC1I2 IARS2 WARS1 WARS2 AURKB DYNC1I1 DYNC1H1 TFG GOLGB1 GLUD1 NFKB2 ANK1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ACE2 LAMB2 FN1 LAMB1 LAMC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 RPS20 LRR1 CCNF FAU RPS21 UBE2L6 RPS24 B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B ASCC2 ASCC3 CDC34 SFTPA2 PSME1 FSHB INHBB UBE2J2 INHBA INHA INHBC INHBE SEC31A SIAH1 FBXL8 EIF4EBP1 CALR FBXL4 EIF4E EIF4B LRRC41 GAN RRAGA KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 CUL7 CUL5 UBA6 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H YKT6 KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 SEC61A2 SEC61A1 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 GALNT1 CALCA ARFGAP3 ARFGAP2 IAPP MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 TPST2 SEC16A KTN1 TPST1 TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RPL4 RPL5 RPL30 RAD52 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A MATN3 RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 CHD3 RPL23 BMI1 RPL22 RPL13A SUMO3 RPL9P9 SUMO2 RING1 RPL37A PIAS1 RPL24 HDAC4 RPL27 HDAC2 RPL26 L3MBTL2 RPL29 SATB1 RPL28 SATB2 RPL10 RNF2 RPL12 ZBED1 RPL11 RPL36A SUZ12 CBX8 RPL14 PHC2 RPL13 PHC1 RPL15 CBX5 RPL18 CBX4 RPL17 PCGF2 RPL19 CBX2 RPL39L PHC3 RPL41 AMER1 RPL35A RPL23A RPL3L AXIN1 RPL27A RPL22L1 APC ABCE1 RPL26L1 CDC73 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 RWDD3 UBA2 SAE1 CREBBP AREG NFE2L2 SAA1 TGFA EIF2AK2 MGAT3 APEH HEMK2 ETF1 GSPT2 GSPT1 APOB MME CES1 USO1 TUBB8 RAB2A TUBB8B EIF2B5 EIF2B4 EIF2B3 EIF2B2 RAB1A EIF2B1 RAB1B HGS RAB5A TOP2A GORASP1 STARD7 FDX1 OMA1 OPA1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 FUT8 MITF GANAB MAN2A1 MGAT5 MGAT1 MGAT2 OST4 EDEM2 MOGS ARF3 ACHE DDOST MGAT4C HTRA2 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 LONP1 TRRAP CCP110 BCHE KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 AGT USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PIAS4 VDAC1 CFTR GATA3 BRCC3 SNX3 RHOT1 RCE1 ZRANB1 SIAH2 INO80 STAM TADA2B CYLD H2AC25 H2AC21 BAP1 WDR48 OTUD7A OTUD7B RAB4A BABAM1 IFIH1 BABAM2 UCHL1 TRIM4 UIMC1 UFD1 IKBKG TOMM70 RIPK2 ACTL6A JOSD2 UCHL3 JOSD1 ALAS1 UCHL5 DDB2 KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 USP17L21 USP17L20 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 SFTPC USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 ECI1 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 CLSPN SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 STAR USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 USP25 USP26 USP20 USP21 RAB32 USP22 RAB35 TAF10 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 HADH RAB39B RAB8B RAB33A RAB7B RAB21 CHML RAB11B RAB12 RAB13 ARG2 ALPI HNRNPK PIGS PIGU PGAP1 PIGT GPAA1 PIGK OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 CDH2 METTL21A KIN MYO5A METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT MYRIP EEF1AKMT2 EEF1AKMT1 DDX5 FFAR4 GRP U2AF2 GALNT11 GALNT14 GCG GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNTL6 P2RY2 ADRA2C COL7A1 ADRA2A MDC1 MT-CO1 B4GALT1 DTL MT-CO2 MT-CO3 GATA4 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 FOXL2 HIC1 SP3 ALDH2 PPARG PPARA LY6E MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 BGLAP SPP1 SUCLG2 UQCRC2 OGDH MT-ATP6 RORA FH DLST ATP5PF ATP5PD MDH2 ATP5F1C MT-ATP8 ATP5PO NDUFA13 SOCS3 NDUFV3 ATP5MG NDUFV1 IDH2 UQCRQ MT-CYB ETFB ME2 IDH3A FBXO32 SFTPB SFTA3 SFTPA1 NDUFS1 NDUFB6 COX4I1 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 RABGGTB ADGRF5 RABGGTA NDUFA2 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 EEF2 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NR5A1 PCNA COX5B COX5A RELA NPM1 NR3C1 NPPA KLK3 SP100 KLK2 RAB9A RAB9B KIF5B KIF5A VDR IL6 PCSK2 ERO1B CPA3 CDX2 LEP ENPEP CPB1 SENP5 CLTRN SENP2 NOP58 TRIAP1 ACE CPE REN CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 IGFBP2 SHISA5 PDIA6 PAPPA MXRA8 SPARCL1 IGFALS AURKA SCG2 KLK1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A ZNF131 FUCA2 UHRF2 DDX17 HRC CASP8AP2 MELTF MBD1 SERPINA10 SAFB MIA3 MSLN TOPORS PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 B4GALNT2 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 TOP2B TOP1 SERPIND1 GOLM1 POFUT2 GZMH NUCB1 NOTUM POFUT4 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 PRELID1 LYPD8 LYPD6B PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CPB2 LRRC49 PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 CHM TTLL1 TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H ING2 SPRN SPACA4 NICN1 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 RAB22A CD59 CD52 CD55 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 RAB40A ZNF350 RAB40B RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 RAB29 RAB15 RAB19 RAB17 TTLL10 NFU1 TTLL13 MEN1 TTLL11 TTLL12 IGFBP1 UMOD LIAS OTOA RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FUCA1 WDR5 RAB3D RAB44 RAB31 RAB37 RAB5B RAB5C HDAC7 RAB6A TRAPPC1 RBBP5 RAB4B RBBP7 FCGR3B KLF4 PML MSRA PCMT1 MSRB2 MSRB3 MSRB1 TTR RAB24 RAB10 TSPAN14 RAB18 ANPEP TXN COMMD9 PARP1 BST1 VNN1 CTSZ CTSH CTSC COMMD3 KCTD6 NR4A2 SRP14 THRB CGB8 COPB1 NR2C1 THBS1 HSPD1 ADA2 POMC ATP6AP2 FGA PLAUR FGG CAND1 F7 F9 PROC F10 GGCX PROS1 PROZ F2 GAS6 DBT DLD PCSK9 APOA2 APOA1 APOA4 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB BTRC ADAMTS13 MTA1 HSD17B10 EPRS1 TRMT112 SOCS2 SOCS6 IKBKE CETN2 ACTR1A CSNK1D DCTN2 DCTN3 JMJD6 RIOX2 ANO8 RNF168 ANKRD28 ASPH PPP6C PPP6R3 TP53BP1 COP1 SMC1A SMC3 STAG1 STAG2 RAD21 TDG DCAF13 PRL CALB1 NAT8B BACE1 APCS TSPAN33 GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI ITM2B CSF2RB CSF2RA NCOA2 PNPLA2 TTF1 CTBP1 DNMT1 DNMT3B DNMT3A SLC30A8 SLC30A5 STS ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD SFTPD TUFM UBE2L3 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MARS1 DARS1 SARS1 EEF1E1 GSN KARS1 IARS1 UBE2T OTULIN ALDH1B1 APH1A PSENEN NCSTN APH1B ADAM10 FBXL18 FBXL7 SDC2 TMED2 GPC3 ADORA2A UCN MBOAT4 PLA2G7 CRHR2 GH1 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 TSHB DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF1 NPLOC4 DDA1 RPLP0 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CISH CUL9 DPP3 HSPA9 UBD NAE1 SOCS5 WDTC1 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B CAPZA1 NEURL2 ERCC8 PSME2 GOSR2 SSR1 ARFGAP1 SRPRA SRPRB PREB KDELR3 PCCB PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 RWDD1 SEC11A JMJD4 KDM8 SEC11C JMJD7 RIOX1 OGFOD1 DRG1 DRG2 RCCD1 ZC3H15 ADORA2B SHMT2 STX5 CMA1 IDE CAPZB GATA6 CTSD TFAM SCFD1 SPTBN1 PARK7 MUC13 INS FGF23 ABCA3 GRIA1 CKAP4 SENP1 CALM1 NDUFS3 UBE2C UBE2E1 UBE2D1 PDHB UBE2S CDK1 DLAT BLM PDK1 BRCA1 PDHA1 WRN BARD1 FBXW11 RPA1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 RAB41 KIF5C KNG1 COG8 COG7 COG6 COG5 IGF2 COG4 RAB27B COG3 CTSG IGF1 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG LTF MAN1A2 F5 TMED3 F8 MMRN1 MAN1A1 TMED7 PLG TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B ARF5 NAPA NAPB GOSR1 NAPG GOLGA2 LYZ BPIFB2 MAN1C1 SEMG1 SPG7 GALNT2 AFG3L2 ARCN1 SMDT1 YME1L1 PMPCA MICU2 COPG2 COPG1 LTBP1 TCF7L2 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A CHCHD2 CTNNB1 EIF2S2 EIF2S1 EIF2S3 ECH1 SPTB ACOT2 STX1A MYC LDHD ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 SPTBN5 PSMD2 PSMD3 SPTBN2 PSMD1 NUP214 CS PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ACO2 PABPC1 UBA52 PSMD12 SEC61G PSMD11 TIMM17A PSMD14 SEC61B PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 TIMM22 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 PSMC5 PSMC6 TIMM9 PSMC3 PSMC4 PSMC1 PSMC2 TIMM10 EIF4G1 ATP5F1A ATP5F1B PEX10 PEX12 SRD5A3 C3 PEX13 PEX14 FURIN IL33 RNF20 CCT2 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC CCT7 B2M HLA-A VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT CCNE2 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 H2BC11 RARA H3C15 RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 HDAC3 KDM1B GNAT3 NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 FBXL21P ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 SLC34A2 MRPS17 SLC34A1 MRPS15 MRPS16 MRPS14 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR BTRC JAK2 SKP1 RBX1 CUL1 PTPN11 GH1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 ALOX15B PTGS2 ALOX15 GPX2 GPX1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix MMP15 COL18A1 MMP17 MMP19 TMPRSS6 NID1 FURIN CAPN8 SPP1 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 CTSG HTRA1 SCUBE3 PRSS2 SCUBE1 BMP1 KLK2 MMP25 A2M TIMP2 ADAM17 SPOCK3 CAPN13 TIMP1 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 DCN TLL1 BCAN PLG LAMA5 LAMB3 CMA1 ELANE LAMA3 ADAM8 LAMB1 LAMC2 LAMC1 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST MMP1 MMP2 CTSD MMP3 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 NCSTN COL23A1 HSPG2 ADAM10 PSEN1 ACAN COL9A1 CD44 COL9A3 COL9A2 CDH1 CTSS ADAMTS4 ADAMTS5 ADAMTS1 ADAMTS8 ADAMTS9 KLKB1 ADAMTS16 ADAMTS18 MMP8 MMP9 PRSS1 PHYKPL CTRB2 CTRB1 OPTC KLK7 CTSB BSG CTSV MMP20 MMP24 CTSL TPSAB1 MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 CASP3 MMP16 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT5A STAT5B STAT3 IL22 JAK3 STAT4 JAK2 IL20RA IL20RB IL22RA2 JAK1 STAT1 IL22RA1 IL10RB PTPN11 TYK2 IFNLR1 IL20 STAT2 IL26 IL24 IL19 IFNL2 IFNL1 IFNL3 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers JUN ADCY9 NTRK3 NTF3 ADCY4 ADCY3 PDGFB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 IRAK1 ITPR2 ITPR3 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PRKAR1B PRKAR2B PDGFRA PRKAR1A RAC1 PRKAR2A PRKX KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PRKCD PRKCA PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 AHCYL1 PSMC4 PDE1C PSMC1 CSNK2B CAMKK1 PSMC2 CAMKK2 GRK2 KPNA2 PRKCG TP53 PRKCE NBEA CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 PLCG1 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 CAMK2B ESR2 CAMK2D HDAC2 SRC NR4A1 CAMK2A NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 CALM1 GSK3B CAMK2G IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK CAMK4 FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 TGIF2 EED POMT2 POMT1 PRKCI RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures MUS81 FIRRM BLM SLX4 RTEL1 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 PGM1 GALM DHDDS DPM1 NUS1 DPM2 DPM3 GALK1 MPI GALE PMM2 GFPT1 DOLK GNE GALT POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events PRKCA GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 ADRA2C RGS4 ADRA2B RGSL1 ADRA2A GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCB GNAI3 RGS20 PRKCH RGS17 GNAI1 RGS19 PRKCG PRKCQ GNAI2 PRKCE RGS16 GNG10 GNG12 PRKCD GNG11 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G2D PLA2G2E PLA2G3 PLA2G5 PLA2R1 PLA2G10 LPGAT1 PLA2G4F PLA2G12A PLA2G4D PLA2G4B PLA2G2A PLA2G1B LPCAT4 CRLS1 PLA2G2F LPCAT1 PLA2G4A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse PLXNB1 ERBB2 RHOC SEMA4D RHOA LIMK2 RHOB LIMK1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MYH10 MYL9 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 PTEN EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 AKT2 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 TRIB3 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A THEM4 PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PHLPP2 PIP5K1C PHLPP1 CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN AKT3 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism ALDOB GLYCTK SORD KHK ALDH1A1 TKFC AKR1B1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria ASL KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF28P KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIF5C KIF21A KIF21B KLC1 KIFAP3 KLC4 KIF2A KLC3 KLC2 KIF2C KIF2B KIF16B KIF3A KIF20B KIF3B KIF3C KIF5B KIF5A KIF18B KIF26A KIF4B KIF26B KIF4A KIF12 CENPE KIF11 KIF23 RACGAP1 KIF15 KIF19 KIF13B KIF1C KIF1B KIF18A KIF20A KIF1A KIF25 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes CREBBP PRDX1 ATF4 MAFK SLC7A11 GCLC NFE2L2 EP300 GCLM NQO1 GSTA3 GSTA1 SRXN1 CHD6 HMOX1 TXN SOD3 BACH1 TXNRD1 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease SOS1 CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 NRAS TRIM24 PLCG1 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 HRAS ZMYM2 GAB1 FGFR1OP2 FRS2 GAB2 PIK3CA SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC PHOSPHO1 CHPT1 ABHD3 PCYT1B PCYT1A CHAT CHKB CHKA STARD10 MFSD2A ACHE LPCAT1 PCTP LPIN1 LPIN2 LPIN3 CSNK2A1 CSNK2A2 CEPT1 BCHE CSNK2B STARD7 PEMT SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PLCG1 FGF20 FGF23 FGF22 FGF16 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency CPS1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CHTOP ALYREF DDX39B SRRM1 DHX38 NXF2B NXT1 UPF3B MAGOHB RNPS1 NUP205 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency BTD LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs RHOC PPP1R12A RHOA LIMK2 RHOB PAK1 LIMK1 ROCK1 MYL12B ROCK2 MYL6 MYH9 CFL1 MYH14 MYH11 MYH10 MYL9 PPP1R12B PPP1CB DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) UBC TICAM2 TICAM1 RPS27A TBK1 IRF3 TRAF3 OPTN LY96 UBA52 CD14 IKBKE IRF7 TANK PTPN11 UBB TLR4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription HES1 HDAC5 CCNC HDAC1 UBA52 HES5 TLE4 HDAC3 HDAC8 TLE2 HDAC9 TLE1 HDAC6 HDAC7 HEYL MAMLD1 TBL1X UBB RBPJ CREBBP UBC CDK8 MAML2 NCOR2 MAML1 RPS27A HEY1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 EP300 SNW1 HDAC11 MYC HEY2 HDAC4 HDAC2 SKP1 RBX1 MAML3 NBEA HIF1A NOTCH1 CUL1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines NSD2 KMT5C SUV39H1 MECOM H4C9 RELA EED SMYD3 NFKB1 ATF7IP SETD1B SETD1A AEBP2 RBBP4 NFKB2 EZH2 RBBP5 PRDM16 RBBP7 KMT2D PRDM9 EHMT2 EHMT1 ASH2L KMT2C KMT2B SETDB2 SUV39H2 SETD2 SETD3 SETD6 SETD7 H3C8 ASH1L DOT1L SMYD2 NSD3 SUZ12 NSD1 DPY30 SETDB1 WDR5 KMT2A KMT5A H3C15 KMT5B METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway GOT1 MRI1 MTAP APIP ENOPH1 ADI1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes JUN PMS2 MLH1 CDK12 CDK13 FANCI MDC1 ATF2 FANCC FANCD2 CCNT2 ELOB ELOC CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L MSH2 GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 BRCA1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 CHEK1 NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 DDB2 CDK9 TCEA1 RAD51D FOS TP53 ATM ATR FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation SERPINA5 CD177 THBD F13B PRTN3 SERPINC1 F13A1 PROC F10 SERPIND1 F5 FGB PROS1 F8 PF4V1 FGA F2 SERPINE2 FGG PF4 F2R PROCR RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB8B RAB43 RAB14 RAB41 RAB33A RAB7B RAB21 RAB27B CHML RAB11B RAB12 RAB30 RAB13 RAB36 CHM RABGGTB RABGGTA RAB9A RAB6B RAB9B RAB39A RAB22A RAB3D RAB40A RAB40B RAB44 RAB40C RAB3A RAB33B RAB31 RAB2A RAB37 RAB5B RAB5C RAB3B RAB3C RAB42 RAB11A RAB6A RAB1A RAB2B RAB1B RAB4A RAB4B RAB34 RAB5A PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB7A RAB29 RAB32 RAB15 RAB35 RAB19 RAB17 RAB27A RAB38 RAB24 RAB8A RAB10 RAB18 RAB39B 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4F3 CYP4A22 CYP4B1 CYP2U1 CYP2S1 CYP4F2 CYP2W1 CYP2D6 CYP4A11 CYP3A43 CYP4F22 CYP4F11 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle ARHGEF9 ARHGAP26 OBSCN MPP7 VANGL1 ARHGAP32 ARHGEF7 ARL13B RHOQ TRIP10 CDC42 CPNE8 STEAP3 GJA1 FNBP1 SCRIB GFOD1 LAMTOR1 IQGAP1 TFRC IQGAP3 SNAP23 CFTR ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 GOPC SYDE1 ARHGAP33 OPHN1 GIT1 WASL PLEKHG3 DEPDC1B CDC42EP1 VAMP3 RAB7A CDC42EP4 CDC42EP3 CDC42EP2 ITSN1 ARHGAP17 SLC1A5 ARHGAP21 PREX1 STOM PAK1 CDC42BPB SRGAP2 CDC42BPA PAK2 DLC1 PAK4 DIAPH3 GIT2 CAV1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol TRIT1 ADAT2 TRMT6 TYW5 TRMT61A TYW3 TRMT5 TYW2 TYW1 LCMT2 ALKBH8 THG1L TRMT44 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B EPRS1 TRMT13 TRMT11 QNG1 TP53RK WDR4 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 URM1 LAGE3 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress CXCL8 DCP2 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EXOSC4 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP DIS3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome HBEGF PXN AREG EGF PIK3R1 EGFR SRC CSK TGFA GAB1 EREG PIK3CA BTC PTPN11 EPGN PAG1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 RBX1 NOTCH1 CUL1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A3 SLC22A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints PLK3 CDKN1A CDKN2A CDC25A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 CHEK1 PSMB5 CSNK1E CCNE1 NEK11 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 TP53 CCNA1 ATM CUL1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB ACADL HADHA SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAP2K1 MAP2K2 MAPK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN DOCK3 RAC1 GRIN2B NTRK2 BDNF SRC MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN PRP4K ZCRB1 WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina PRKCB PRKCA EMD LMNB1 LPIN1 CCNB1 LPIN2 LPIN3 CNEP1R1 CDK1 LEMD3 LEMD2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response OAS1 OAS3 ABCE1 RIGI RNASEL FLNA OAS2 PDE12 OASL PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane TMEM258 DAD1 OSTC STT3A STT3B RPN2 TUSC3 PDCD1LG2 B3GNT3 RPN1 PDCD1 MAGT1 MIB2 OST4 JAK1 CD274 DDOST RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 CDC42 KLC4 RAC1 KLC3 KLC2 KTN1 KIF5B RHOG KIF5A RHOA KLC1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins LY6E CD109 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 BST1 LYPD6B PIGO VNN1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH ALPI LY6K GPIHBP1 LY6D LY6H SPRN SPACA4 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 CD52 PRND CNTN5 CEACAM5 ALPL CNTN3 CNTN4 ALPG TEX101 GPLD1 GP2 PRSS21 PRSS41 DPM1 DPM2 DPM3 TECTA TECTB VNN2 PIGS PIGU PGAP1 PIGT GPAA1 PLET1 CPM PLAUR PIGK PSCA MELTF RTN4RL2 MSLN FCGR3B RTN4RL1 OTOA RAET1G RAET1L IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM FOLR2 ULBP2 OPCML NEGR1 XPNPEP2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 MYO6 AP2M1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation CYB5B NOSTRIN HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NOSIP WASL DNM2 NMT2 AKT1 ZDHHC21 CALM1 CAV1 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB PDHX FH SUCLA2 MPC1 SUCLG2 HEL-S-133P SUCLG1 GPT DHTKD1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN3 COMP MATN1 COL9A1 COL9A3 COL9A2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 TGFB1 STAT3 ENPP2 RHO LPA CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC4 TUBA2 PSMC1 STUB1 TUBA8 UBE2L6 PARK2 UBE2L3 HEL-S-89n TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD5 PSMD2 RNF19A TUBB1 PSMD3 PSMD1 GPR37 FBXW7 HEL-S-103 TUBB HEL-S-72p CASK SEPT5 TUBA4B TUBA4A TUBB2A CCNE1 PSMD10 PSMD12 PSMD11 HEL-S-91n TUBAL3 PSMD13 HSPA14 UBE2J2 UBE2J1 TUBA3E SNCA HSPA4 SIAH2 SIAH1 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B TUBB4A PSMC6 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 INSR PDX1 PDGFA BRAF IGF1 FOXM1 TGFBR1 FOXO1 IGF1R INS RAB43 RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways RGS16 CAMK2A ADCY3 ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G CORIN GUCA2B GUCA2A RGS10 ACKR3 RGS11 RAMP1 ACKR5 ACTA2 ATF1 ATF2 MYLK2 HEL2 OXTR CRCP GABPB1 ETS2 SLC8A1 RXFP2 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 IGFBP1 PRKCH IGFBP5 PRKCB IGFBP4 PRKCE IGFBP2 PRKCA DGKZ MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA LPAR1 HEL-S-14 ITPR2 PRKCZ CRHR1 CNN2 GRK5 GRK4 CALD1 PLCG2 SFN PLCG1 IGFBP6 JUN GNG12 GNG11 NFKB1 GNG13 PKIB IL6 SP1 PKIA GNB2 MAFF GNB1 GNAS GNB4 GNB3 RLN1 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADM OXT ARRB2 RYR3 GNGT1 YWHAQ PS1TP5BP1 PDE4B HEL-S-1 YWHAG GABPA HEL-S-21 PDE4D FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 RGS17 CAMK2D RAMP2 RAMP3 RGS14 ATF6B 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2I2 HEL-S-71 NRROS TFRC CEP19 HFE SLC40A1 PIGX H2BC21 UBXN7 SMCO1 DYNC2H1 NCBP1 DYNLT1 NCBP2 DYNLT3 ADAM10 SLC51A SLC51B SIRT1 DYNLL2 FNDC8 RNF168 PIGM MFI2 DYNLT2B PXN MYCBP2 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 ZDHHC19 BRINP1 STAT5B TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP WDR53 ZNF76 TF DYNLRB2 NF2 DNCL1 HAMP TGFB1 JUN FBXW7 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 E2F3 MYC PIK3R1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 PARP1 NAMPT TFAM HIF1A PPARG FOXO3A ROS1 SIRT1 SIRT3 FOXO1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 MAPK1 MAPK3 PIK3R1 SLBP CBL FGF2 ERI1 NSD2 TMEM129 CLTCL1 NELFB UBE2J2 FAM53A NELFCD NELFA POLN H3F3B FRS2 CKAP5 LETM1 NICOL1 TACC3 GRB2 NAT8L SOS1 FGFR3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2C MEF2B CCND2 NKX2-5 KLF4 MEF2D CAMK2D MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers ADM CRP PBR GRN CCL23 CCL11 BDNF TREM2 DBI S100B TREM1 CX3CL1 IL6 GFAP CCL5 IL1B OLR1 TNF CHI3L1 NEFL CCL2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 APOB LDLR PLTP USF1 GPIHBP1 LPL GHR LIPC EPHX2 APOA2 PCSK9 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies IL6 C1QB C1QA CD40 IL25 CD80 C4B_2 C2 C4A CD19 IL12B TNLG7A IL12A IL6R HEL-S-62p CD40LG IFNG IL23A IL17F IL17D IL17C MS4A1 IL17B CD22 IL17A C1QC EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1H1 DYNC2H1 DCTN1 TRAK1 ATAT1 DYNC1LI2 RHOT1 SYPL1 CASP3 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A SNCA DYNC2I2 CASP8 RAB3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome VCP IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 E2F4 CIMAP3 SNAPIN PTCH1 CEP19 RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 DNM3 TFDP2 SMO RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 STX5A IFT25 RABL2B SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 SMAD4 HEL113 TNC RUNX2 CDH6 CDH2 ID1 SNAI1 SNAI2 CDH16 AKT3 MAPK1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR2 TPH2 TPH1 KDM3A GRIN1 CHRM1 KDM1A KDM1B CYP27B1 CALB1 RXRA KDM6B NR1i1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 HEL-75 CYP27A1 GCLC KCNQ2 BCL2 SLC8A1 KCNQ3 PVALB NFE2L2 CACNA1C GRIN2B VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway HADHB CYP2C9 CYP2A6 HSD17B10 CYP2B6 HDAC1 EHHADH IVD ABAT ACADSB FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis TFRC SLC40A1 CYBB GCLC STEAP3 CISD1 SAT2 SLC7A11 BACH1 MAP1LC3A MAP1LC3C AIFM2 FTH1 SLC39A8 HEL-S-64p HEL-S-102 SLC38A1 GPX4 ACSL1 SLC11A2 ACSL6 FACL4 ACSL5 ACSL3 TF SLC39A14 POR DKFZp762B153 CHMP6 CHMP5 FTL IREB2 ALOX15 SLC3A2 HMGCR DPP4 FTMT CBS PCBP1 PHKG2 HMOX1 FDFT1 ATG5 PRNP AKR1C1 AKR1C2 CP COQ2 LPCAT3 VDAC3 CTH GCLM NOX4 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX1A SLC25A4 NAPA SNAP25 SLC22A3 STXBP1 CLTC DNM3 CACNA1B CLTA SLC1A3 CACNA1A AP2A1 CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 AP2S1 SLC17A6 SLC17A7 SLC17A8 CLTCL1 STX2 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B UNC13C UNC13A SYT1 SLC32A1 SLC38A1 SYP SYN2 SYN1 STX1B STX3A VAMP2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IFITM3 ANKRD13C CREBBP HDAC2 CADM1 IRS1 TET2 EP300 PIP4K2A HDAC1 NOL9 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG GATA3 GATA2 KLF15 KLF2 PPARG DDIT3 CEBPA CEBPB EGR2 KLF5 CEBPD ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins DKFZp762B153 RB1CC1 RAB7A ATG5 PRKAA2 CALCOCO2 HEL-S-30 PPP1R9A RPTOR LARP1 MTOR ULK1 DEPTOR LAMP2 MLST8 VPS11 APOB VPS39 EIF4B VPS16 ATG3 VPS18 GABARAPL2 VPS33A RPS6 ATG9A ATG12 VAMP8 TMEM59 RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 NBR1 LAMTOR1 SQSTM1 ATG2B OPTN INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 GRN SIRT1 RHEB MYCBP2 RB1 SMEK1 ZMYND8 NAB1 DHTKD1 MAP3K7CL AHR STK11 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 CSNK1D TSC1 ARAF PPP4R3B BAX MYT1 RHO CCNB1IP1 CDC25B PIAS1 MSH6 EDAR MSH2 LGALS13 BLM MAX RASGRP3 RAP1A RRAS NUP85 TPR BARD1 CASP8 UBE2F SMAD1 PLK3 APOBEC3G GADD45A PIK3R2 XRCC3 PLK1 ERAL1 SMAD6 SMARCA4 FADD FOSL2 FOSL1 FER CDK7 NOXA1 NF1 MDM2 ATM ZNF655 MAP3K13 CERK BMPR1A ATR PIGR GSK3A BMPR2 GDI1 TRADD PTEN BRCA1 BRCA2 RASGEF1A RAC1 JAK1 ANXA1 DCAKD TGFBR2 ITPKC USP15 RALA USP16 SELENOK TFPI SMAD2 EGFR SMAD4 AURKA PAK1 BAK1 STAT1 USP21 MRE11A BRAF PML HIPK2 VEGFA TGFBR1 MAP3K7IP1 FOXO1 WEE1 RAD50 RAD51 FILIP1 CTNNB1 FAU CDK4 MYC IRS1 CDK2 MAPK1 KRAS ATF1 BCL2 HDAC1 BACH1 CASP9 CASP3 CHUK HMGCR JUN NFKB1 SP1 PKIA BAD MTOR CDC42 CREB1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP9 CASP3 APAF1 BAX TNFRSF1A NEF3 TOMM40 SLC1A2 DERL1 HEL-S-2 TNF NEFH NEFL MAP2K6 MAP3K5 GPX1 BAD HEL-S-44 MAPK14 MAP2K2 CCS SMIM40 RAB5A BCL2L1 BCL2 PPP3CA CASP12 RAC1 PPP3CC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism RELA INSR CRP CBS INS NFKB1 IL6 CCL5 TNF CCL2 CTH HEL-S-44 SCARB1 APOB SERPINA3 LDLR MTRR SAA4 HBB APOE MTR PLAT PLG HEL-S-51e MPO MCEE ABCA1 FGA CUBN CBLIF HBA2 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG TCN2 TCN1 IL1B ALB SAA1 SAA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 HEL-S-30 HEL-75 EHHADH PDHX FH HEL-S-133P SUCLG1 HEL-S-64p PNMT HEL-S-32 HEL-S-61p DBH FTCD GLS TDO2 HEL-S-53e PDK4 ACADM PIG59 HEL-S-4 ARG2 RARS1 ARG1 GPT2 MCCC1 CAD SDHA HEL-S-26 CBS ACLY LARS2 SMS BCAT1 ALDH7A1 DLD DDC ADH1C PPM1L MAOA HDC ADH7 CTH ADH5 GCLM SRM HMGCL TPO PCK1 ACSS1 PDHA1 MDH2 GOT2 ASNS ASS1 CS GLUD1 G6PC2 HAL PC TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 IARS OTC FARSB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 TDO2 IDO1 FOXO1 KLF5 CDKN1A IFNB1 IFNG AADAT HEL-S-90n HAAO TNF IL1R2 EIF2AK1 AHR EIF2AK4 KMO KYNU AFMID IDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling ITGB1 HEL-S-130P PRL HEL-S-69p PAK1 RPS6KA2 SIRPA RELA STAT1 NEK3 CISH GAB2 PRLR VAV1 VAV2 ZAP70 PPIB SRC SHC1 AGAP2 SOCS2 MYC SOCS3 SOCS1 IRS1 ERBB2 EIF4EBP1 MAPK1 FLNA FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 NFKBIB RAF1 RPS6 RPS6KB1 PXN STAT5B GSK3B MAPK9 MAPK8 CASP3 STAT3 JUN PIK3CA NFKB1 MTOR PIK3R2 PIK3R1 CBL YWHAG FOS YWHAZ RAC1 JAK1 HRAS GRB2 SOS1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap ETHE1 MAT1A SQOR SUOX CDO1 MTR HEL-S-64p CTH HEL-S-61p CBS GCLC COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system CRP CSNK1A1 FCN1 FCN2 CLEC4M CD40 ITGB3 PLG PROS1 ITGA2B ICAM2 F13A1 C2 C4BPA C4A FGA LAMC1 CD19 C8A FCGR3A IBSP RPS19 C1QBP PRKCA HEL-S-62p HEL-S-78p C3AR1 VSIG4 MBL2 CR2 CR1 ALB CD93 ITGA2 HEL-S-92n PLAUR DCN FCER2 SERPING1 MASP2 MASP1 CD46 CFD LAMA5 FKBP2 SELPLG SFTPA2 CFH C5AR2 CFI C5AR1 WAS FPR1 GNAI3 TXN HEL-S-99n CFP THBS1 CPN1 VTN PRNP GNA15 C6 C7 C9 SPP1 CD59 CD55 ELANE F10 F11 LAMB1 SELE SELP SELL CFHR2 ADM CFHR4 PTX3 ARRB2 SFTPA1 KLKB1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC34A3 ATP6V1G1 SLC6A19 ATP6V0B ABCC2 SLC6A18 SLC36A2 ATP6V0E1 SLC34A1 SLC16A10 SLC3A2 ATP1B1 SLC9A3 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ABCG2 ATP6V1B1 SLC47A2 ATP6V1A SLC22A6 ABCB1 SLC47A1 SLC22A2 SLC1A1 SLC2A2 SLC3A1 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 SLC5A5 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1D ATP6V1C1 ATP6V1F SLC22A11 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACTA2 COL1A1 RAF1 SMAD4 TGFB1 CTGF TGFBR1 NOX4 HIF1A RRAS SP1 IL11 JUND MAPK1 IL11RA MGRA MAP2K6 ACE2 PTPN11 COL1A2 TGFBR2 PDGFD AGTR1 IL6ST OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH3 NOTCH1 DMP1 HNF1A BMP7 KLF4 DSPP ALPL RUNX2 SP7 SOST CTNNB1 DKK1 NOTCH2 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies GSK3B SMAD2 CREBBP TGFB1 RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 WNT7B CEBPD CTNNB1 CDK4 MAOA SPP1 APC CSNK1A1L NOTCH1 PPARG WNT10B HDAC1 LEF1 TNFRSF11B PS1TP5BP1 ZMPSTE24 FNTA CTSK LMNA HES1 EMD JUNB HES5 TCF7L2 CDKN1A TCF7L1 ICMT RB1 HMGA2 DICER1 LEMD3 TARBP2 GDF8 KAT2B BMP2 MYOD1 AGO2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG MAFK COX1 NFE2L2 PTGS2 CYP2A6 VEGFA JUN FOS NFKB1 IKBKB NFKBIA KEAP1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members GSK3B CREBBP EP300 CHUK ZC3HAV1 RELB TBK1 IKBKG BTRC SKP1 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CLDN6 MAVS MAP3K14 RIGI NFKBIA ERN1 PARP1 NFKB2 IKBKB LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS TLR4 ICOSLG CD40 CD80 TNLG7A IL6 CD40LG IFNA2 TNFRSF13C BCR TLR9 IL17A TLR7 PDCD1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 TGFBR1 IL10RA SLC7A7 LHFPL2 HIMAP2 GAPT NRROS GPX1 RGS1 HEL-S-62p C1QC SPP1 CD84 ITGAM FKBP15 NCF2 PLEK LOXL3 TCIRG1 PPP1R18 CXCL16 PYCARD LYL1 RPS6KA1 CREB3L2 ITGAX CD37 GAL3ST4 IL13RA1 RNASE6 IL18 HEL-S-66 TNFRSF1B RUNX3 LGALS9C APBB1IP MAF TYROBP BIN2 ELF4 NPC2 DPYD EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance EGFR PDGFA NRAS BRAF IGF1 VEGFA IGF1R SRC KDR SHC1 PDGFRA PDPK1 MYC HGF AKT3 RRAS2 NRG1 ERBB2 NRG2 EIF4EBP1 MAPK1 SOS2 KRAS MET MAPK3 SHC4 SHC2 MAP2K1 SHC3 PDGFD MAP2K2 TGFA BCL2L11 ERBB3 PDGFC BCL2L1 EIF4E BCL2 EGF RAF1 AXL RPS6KB2 FGFR2 RPS6 RPS6KB1 PRKCB IL6R PRKCA PIK3R3 CCND1 GSK3B PIK3CD STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA IL6 RRAS BAD MTOR PIK3R2 PIK3R1 FOXO3A NF1 FGF2 PTEN JAK1 HRAS GRB2 SOS1 FGFR3 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGS2 PPARG PTGFR HEL-S-298 EHHADH HPGD PTGDR2 CYP4A22 AKR1B1 PLA2G5 PLA2G6 NR1C2 PTGS1 TBXA2R PTGDR PTGIR PTGIS PLA2G4B CYP4F2 CYP4A11 PTGR1 CYP4F12 ACOX1 PRXL2B ACOX3 PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IF2B1 TLR4 IL23R RORC RORA SMAD2 NOD2 IL2RG IL-21 TGFB1 HLA-DMA STAT1 STAT3 IL18RAP TBX21 STAT4 IL21R IL12RB1 IL10 JUN IFNGR1 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL2 IL4 IL6 IL5 TLR5 TNF IL12A IL18 IFNG IL23A IL17F MAF IL1A IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling PIK3CD MAPK8 TGFB1 STAT3 GAB2 VAV1 JUN SRC SHC1 CXCL8 IL5RA MAPK1 CSF2RB CRKL FYN MAPK3 INPP5D BAD ENPP3 PTPN11 CCR3 MAP2K1 LYN PIK3R2 SYK PTPN6 PIK3R1 IL3 IL3RA BCL2L1 BCL2 RAPGEF1 CD69 RAF1 YWHAQ CBL HEL-S-1 FOS JAK1 STAT5B HRAS GRB2 SOS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NFKB1 SP1 MAOA GPX1 HEL-S-44 MAPK14 HEL-75 CYBB GCLC MGST1 GSTT2 NFE2L2 TXN2 UGT1A3 XDH NQO1 GPX3 TXNRD2 NOX3 CYP1A1 NOX5 JUNB FOS NOX4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 FABP6 SLC10A2 ABCB11 ABCC2 SLC51A SLC51B ABCB1 ABCC3 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI LATS1 TEAD4 LATS2 HDAC3 NF1 HDAC1 SIN3A MERTK SKIL TEAD2 TEAD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ECHS1 ACSF3 ACAT1 PCCA PCCB DBT MLYCD BCAT2 MCCC1 IVD ACADSB BCAT1 DLD HSD17B10 ACAD8 MCCC2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development NOTCH1 EGFR SMAD4 MAPK9 FGFR2 FOXC2 FOXC1 MAP3K1 INHBB BMP4 JUN SHH SFRP1 DKFZp781O1323 PITX2 FGF10 DKK2 MAPK3 SMAD1 TGFA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 MAPK10 MAPK9 MAPK8 RPS6KA2 MAP3K1 JUN IFITM1 IFITM2 RPS6KA3 MAP2K3 MAPK1 MAP2K4 MAPK12 DDIT3 MAP2K6 MAPK3 MAPK13 BST2 ATF2 MAPK11 MAP2K1 MAPK14 IFI27 MAP2K2 MAP3K10 MAP3K11 EIF4E BCL2 RAF1 RPS6KA1 JUNB FOS FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway GSTM2 MTTP APOB ACACA MLXIPL ABCC2 FASN PPARGC1B SLC27A5 FOXA2 FOXO1 ABCC3 INS SLCO1B1 IRS1 FOXA1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B1 ABCC2 ABCG2 BCHE CYP3A4 CES2 UGT1A10 CES1 ABCC1 UGT1A1 UGT1A9 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 WNT3 LRP6 FZD3 WNT3A NEUROD1 CCND1 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 TICAM1 PARP1 TRADD FADD MAPK8 FTL CASP8 TNF RIPK3 TNFRSF1A CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2 SMAD4 RELA EP300 CHUK STAT3 RELB IGF1 CEBPB IKBKG IGF1R TNFRSF1A NFKB1 IL6 TNF RPTOR MAPK11 MTOR NFKBIA MLST8 FOXO3A AKT1S1 TWEAK IL6R MAP1LC3A TRIM63 TNFRSF12A NFKB2 IL1R1 IKBKB FBXO32 ACVR2A IL1B REL JAK1 GDF8 IL1A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment BDNF SHC1 PDPK1 EIF4EBP1 PTPN11 NFKBIA BCL2L11 EIF4E RPS6KB2 RPS6KB1 MAPK8 STAT3 BAX CASP8 RAPGEF1 FADD TRADD IKBKB RAC1 SMPD1 HRAS PAK1 NRAS MAP3K1 CTNNB1 MYC IRS1 MAP2K4 MAPK1 KRAS MAPK3 MAP3K5 MAPK11 MAP2K1 HEL2 MAP2K2 BCL2 RAF1 BMP7 LEF1 PRKCH PRKCB PRKCE PRKCA TCF7L2 TCF7L1 ARHGAP35 CFL2 PRKCI TIAM1 PARD3 MAPKAPK2 CYCS RTN4R IQGAP3 GSK3B HEL-S-15 NPTX2 PIK3CD MAP2K5 PRKCZ NGFR CASP9 EEF2 TP73 DOCK7 CHUK WASL APAF1 EEF2K TRAF6 CRK PLCG1 IKBKG ROCK1 ROCK2 JUN HEL-S-47e PARD6B PIK3CA PARD6A MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 LIMK1 ARHA BAD MTOR CDC42 FOXO3A YWHAQ HEL-S-1 YWHAG YWHAZ CREB1 FRS2 GRB2 SOS1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FGFR2 PIK3R3 MAPK10 MAPK9 MAPK8 FZD10 PTCH1 SMAD1 PIK3R4 PIK3R2 PIK3R1 SMO FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 SMAD4 RUNX2 STAT1 FGFR4 BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 WNT5B NOTCH2 NOTCH3 NOTCH1 PRKCH PRKCB PRKCE PRKCA WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PRKD1 BMP2 MYOD1 WNT2B PIK3CD PRKCZ WNT16 PIK3CA MAPK7 LRP5 LRP6 IHH RBPJ FGF7 FGF8 FGF9 SOX9 HES6 PRKDC PIK3R5 JAG2 FZD4 SMAD9 FGF18 FGFR1 PPARG PIK3C2G PIK3C2A GLI3 PIK3C2B HEY2 FGF2 WNT9B FGF7B WNT9A FGF7A WNT8A WNT8B DLL3 DLL4 HES3 MAPK6 HES2 MAPK4 FGF5C FGFR3 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling NLRP3 MMP9 IRF7 KLRD1 TGFB1 CCR2 VEGFA NFKB1 IL6 CSF1 CXCL8 TNF CCL2 PYCARD IL12A IFNG IL1B IL17F PTGER4 CXCL9 IFNA1 AHR PTGER2 CXCL1 IL17A AREG CCL3 IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP ASCL1 CXCL2 MBP MYT1 SOX8 SOX6 IGF1 SOX5 NKX2-2 BMP4 SHH NKX2-6 MOG LIF OMG OLIG1 OLIG2 SOX10 TNF SOX9 FGF2 IL1B BMP2 CXCL1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A FAN1 CREBBP CHRNA7 ARHGAP11B GOLGA8R CCL5 MTMR10 KLF13 OTUD7A FYN GPR75 GOLGA8O KAT2B GOLGA8Q TRPM1 FANCD2 GRM6 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKB1 MUC1 IL6 IKBKB CHUK RELA TNF NFKBIA IKBKG MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CCNG1 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER1 ADCY3 PTGER3 ALOX12 LTC4S PTGS2 GNAI1 ALOX5 ALOX15B ALOX15 ALOX5AP NRAS KRAS GNAS MAPK11 SIRT1 IGFBP5 PTGS1 CDKN1A RB1 PTGIS PTGER4 HRAS PTGER2 PRXL2B PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes ADCY1 HDAC2 EP300 EZH2 PRKAA2 SIRT1 AHR RORC MAPK10 RORA MAPK9 MAPK8 CSNK1D C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC HTR7 CSNK1E PROK2 HEL-S-80p AgRP PROK1 CHRNB2 UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CARTPT MTNR1A CLDN4 MTNR1B PSPC1 TIMELESS UTS2 SIK1 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM TNFRSF11A NPAS2 RAI1 AANAT UBC NKX2-1 DRD1 PTEN DRD2 DRD3 PPARGC1A DRD4 HDAC3 EGR1 SIN3A ZFHX3 OPN4 OPN3 HOMER1 NONO GFPT1 NR1D2 NR1D1 BTBD9 NR2F6 SETX STAR ID2 ID4 HNRNPD ID3 FBXL3 PML SLC9A3 TCF2 OGT ADA TPH2 TOP2A TPH1 KDM5A SUV39H2 CHRM1 SUV39H1 FAS BHLHE41 CDK4 NR1C1 HEBP1 RBM4 DBP JUND SIX3 HEL-S-2 KLF10 KCND2 SFTPC PAX4 MC3R SFPQ NCOR1 ADORA2A THRAP3 MTTP CRY2 KCNMA1 CRY1 AVP NLGN1 PRKAA1 PHLPP1 CIPC HDAC1 CRX RBM4B TYMS NPS PROX1 ATOH7 PROKR1 NFIL3 GNA11 NOCT RPS27A NTRK1 ARNT2 F7 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HS3ST2 HCRTR1 PER2 ATF5 PER1 PER3 ATF4 MYBBP1A GSK3B GHRH LEP KLF9 GHRL NGFR BMAL2 RELB BTRC ROCK2 SKP1 JUN IL6 DDC NOS2 PRKDC NAMPT PPARG TH CREB1 CRH GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other GPR17 P2RY11 HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 CCR2 OR2A5 LGR6 OR2A4 ADGRL2 GPR18 ADGRL3 OR7E24 ADORA2A GPR83 PTGFR CHRM2 CHRM3 OR1G1 OR2M4 GPR61 C5AR2 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 HTR7 EDNRA GPR176 GPR132 GNRHR CCR5 GPR135 UTS2R ADGRV1 ALG6 OR1F1 F2R OR2H1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 SMO GPR162 CCKBR OR5AC2 FSHR ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 ADRB2 IL8RB MCHR2 GHRHR DRD3 FY CXCR1 DRD4 CNR1 CXCR3 S1PR1 OR2B6 NTSR1 OR5D3 P2RY13 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p RB1 PRKAA1 HEL-S-133P HEL-S-30 HEL-S-162eP RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism HEL-S-53e CYP2A6 CYP1A1 ADH1A RPE65 DHRS4 CYP3A7 SDR16C5 CYP2W1 RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT BCO1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PLCB1 CRTC2 INSR PRKAA2 EIF4EBP1 RPTOR PRKAG1 PRKAG2 SLC2A4 ADRA1B ACACA ELAVL1 ADRA1A FASN RPS6KB2 PRKAG3 PPARGC1B NR2A1 PRKAA1 GYS2 GYS1 LIPE PRKACG LEPR PRKAB2 STRADA RPS6KB1 STRADB CPT1C PRKAB1 CCNA2 CAB39 PIK3R3 ADIPOR1 ACACB ADIPOR2 CAMKK1 CCNB1 CAMKK2 INS-IGF2 SLC2A4RG STK11 LEP PIK3CD TSC2 EEF2 TSC1 EEF2K HMGCR PIK3CA CPT1A MTOR PIK3R2 PIK3R1 CDKN1A IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG STAT1 STAT3 CISH GAB2 SHC1 IL2 SOCS3 MAPK1 CRKL FYN MAPK3 PTPN11 MAP2K1 MAP2K2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 CBL RPS6KB1 JAK1 STAT5B PTK2B HRAS JAK3 NMI GRB2 LCK IL2RA SOS1 IL2RB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL15 F2RL1 IL2 ITGB7 EGFR DHODH IFNG IL-21 TNF NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF2S1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway STAR RUNX2 CXCL2 FOXO1 DKFZp781O1323 PDPK1 SLC1A2 EIF4EBP1 MAPK1 TNF MAPK3 PTPN11 MAP2K1 MAPK14 MAP2K2 SLC2A4 EIF4B DYNLT1 BMP7 NFE2L2 DYNLT3 PRKAA1 RPS6 RPS6KB1 PRKCB GNA11 PRKCE PRKCA HIF1A CAMKK2 HCRTR2 HCRTR1 PRKD1 LEP GHRL CASP9 PRKCZ MAPK9 MAPK8 CASP3 GNAI1 STAT3 IL10 MAPK7 IL4 NPFFR1 IL6 DAGLA CXCL8 FSHB SGK1 LHB BGLAP NPY SMAD1 GNAS NPVF VHL MTOR CGA PIK3R2 HCRT PIK3R1 OPRK1 GCG CCK POMC GH1 IL9 GNRH1 ARRB2 TH RPS6KA1 BMPR1A NOX4 CREB1 IL1B MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP16 MMP9 PRKD3 MMP15 MMP23B PRKCZ SCN8A MMP17 MMP19 BDNF NOS2 SNAP25 AGER SLC2A3 PRKCH MMP21 MMP20 PRKCB MMP25 MMP24 PRKCE MMP27 SCN9A HEL-S-62p PRKCA MMP28 MMP7 TRPA1 MMP2 MMP3 SORD TRPV1 PRKCI MMP10 PRKCQ MMP12 MMP11 SCN10A MMP14 CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR TXN AMD1 APIP MAT1A SMS MRI1 IL4I1 MSRA MTAP ADI1 CHDH MSRB2 MSRB3 ENOPH1 SRM HEL-S-61p HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA TFAP2A ARHGAP29 ARHGEF2 IRF6 TP63 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KDR PDGFRA PDPK1 HGF PRKAA2 MET RPTOR MLST8 PDGFC SLC2A4 EIF4E EIF4B EGF ELAVL1 RPS6KB2 FGFR2 GYS2 GYS1 RPS6 LIPE STRADA RPS6KB1 RHEB AKT1S1 CAB39 HIF1A JAK3 STK11 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 ULK1 PIK3R4 PIK3R2 PIK3R1 IL3RA MDM2 SLC2A3 PTEN IKBKB JAK1 HRAS EGFR FGFR4 NRAS VEGFA FGF10 CSF1 IRS1 IRS4 MAP2K1 MAP2K2 FOXA1 HEL-S-125m TCL1B TCL1A ACACA PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 PELO CDC37 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 HIF3A GNGT2 FGF8A RAB8A OSMR COL2A1 KIT PHLPP2 COL11A2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD RAB11B NGFR COL3A1 CASP9 KITLG GHB3 CSF3 CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 PFKFB2 PFKFB1 CSF1R PFKFB4 EFNA5 EFNA4 CHAD FGF20 NOS2 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 FGF16 EFNA3 FGF14 EFNA2 PIK3R5 COL5A3 COL5A2 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 ITGB4 PIK3C2A FLT4 LAMC2 PIK3C2B ITGAE FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C ANGPT4 ANGPT2 ITGB1 LAMB3 ANGPT1 PRL LAMB2 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PRLR PPP2R2B PPP2R2D EIF4EBP1 GHR CDKN1B ITGB3 ITGA2B LAMC1 IBSP IL6R ITGA2 COMP COL1A1 LAMA5 THBS1 VTN SPP1 LAMB1 SLC2A2 PPARGC1A CRTC2 TNC FLT1 INSR PDGFA IGF1 FOXO1 IGF1R INS CHRM1 AKT3 MAPK1 KRAS MAPK3 ATF2 COL1A2 PDGFD PRKAA1 PHLPP1 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 F2R GNB3 ITGAM GNGT1 CREB3L2 ITGAX CREB3 CREB1 ATF6B INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 AKT3 SNCA APP STAT1 CEBPB SRPK2 BACE1 SET BDNF TARDBP MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 BRAF JUN ALK KSR1 SHC1 FOS GAREM2 MYC KRAS SOS2 MAPK3 MAP2K1 MAP2K2 SOS1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR CREBBP HDAC2 RELA EP300 NFATC1 NFKB1 HDAC5 SUPT4H1 HDAC8 SP1 HDAC9 HDAC7 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 NFKBIA CDK9 PPP3R1 PPP3R2 HDAC1 NELFB NELFCD NELFA PPP3CA HDAC3 PPP3CC TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 TDO2 NMNAT1 IDO1 NMRK2 NMRK1 NAPRT NAMPT AADAT HEL-S-90n HAAO KMO KYNU NMNAT3 AFMID NMNAT2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RPS6KA2 SHC1 PDPK1 SOCS3 SOCS1 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 PTPN11 SHC3 SLC2A4 EIF4E RPS6KB2 INPPL1 CBLC RPS6KA4 GYS2 RPS6KA6 GYS1 LIPE RPS6KA5 GRB14 GRB10 ENPP1 MAP3K8 RPS6KB1 MAP3K6 RHEB GYG1 MAP3K7 INPP4A TRIB3 STXBP3 PIK3R3 STXBP4 RRAD PPP1R3A KIF3A STX4A RAB4A EHD1 EHD2 MAP3K12 ARF1 HEL-S-31 SNAP23 PTPRF FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 TBC1D4 SGK2 ARF6 SNX26 MAP4K3 MAP3K2 HEL-S-42 PFKL MYO1C PFKM SGK1 PIK3R4 PIK3R2 PIK3R1 RAPGEF1 XBP1 MAP3K13 GSK3A PTEN IKBKB RAC1 EGR1 HRAS INSR MAP3K1 FOXO1 IGF1R RPS6KA3 IRS1 MAP2K3 IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 HEL-S-61 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 PRKAA1 PRKCH PRKCB PRKCA PRKCI PRKCQ GSK3B PIK3CD MAP2K5 PRKCZ CRK JUN PIK3CA MAPK7 SH2B2 MAP3K14 MTOR SNAP25 STXBP1 FOXO3A PIK3C2G PIK3C2A CBL RPS6KA1 FOS MAPK6 MAPK4 GRB2 SOS1 VAMP2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 TSC2 TSC1 EEF2K NRAS BRAF GAB2 PLCG1 BDNF GRIN1 SHC1 TRPC6 TRPC3 ARC NTRK2 DLG4 EIF4EBP1 MAPK1 KRAS MAP2K1 MTOR RPS6KA1 RPS6KB1 RHEB CREB1 HRAS GRB2 HOMER1 SOS1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades TFPI APOA2 C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 NR1C1 SP1 GPAM STAT3 CYP1A2 CYP1B1 NR0B2 ACOX1 CYP1A1 JUN PCK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2A CAMK2G GRIN1 ARC MAPK1 MAPK3 RYR2 NLGN1 NLGN3 CYFIP1 NLGN2 YWHAG NRXN1 FMR1 NRXN3 NRXN2 GRIN2B RPH3A SYNGAP1 DLGAP1 TJP1 DLG2 SHANK1 CAMK2D HOMER1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 NFKB1 IL18 IL6 MAVS IL1B CSF2 TNF CGAS RIGI CXCL9 MITA CCL2 IFIH1 CXCL11 IRF3 TLR8 TLR7 TLR3 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT1A8 UGT2B7 ABCC2 UGT1A3 UGT1A10 UGT1A1 ABCB1 UGT1A9 ABCC3 SLCO1B1 CYP3A4 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling GSK3B TRAF3IP2 IL17RC IL17RB RELA STAT3 IL17RA TRAF3 TRAF6 CEBPB IKBKG CEBPD PIK3CA NFKB1 SP1 MAPK1 MAP3K14 MAPK3 NFKBIB IL25 MAP3K7 IKBKB IL17F IL17D JAK1 IL17C IL17B IL17A ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 UGT1A3 NQO1 CYP1A2 GSTM1 CYP1B1 UGT1A1 SULT1A1 STS UGT1A9 SULT1E1 CYP1A1 ARSL CYP3A4 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTX1 SPRYD4 CDKN2A AP3D1 TRMT1 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 TRIP13 LAMTOR3 LAMTOR5 LY6K PLXND1 TUSC2 GEMIN2 LTN1 CPOX ARID4B CALCOCO2 MSI2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 VPS39 KPNA3 EIF4E FADS1 AXL MYLIP ATG3 TNLG5A TPM3 TPM1 STX7 GYS1 UBE4A ATG9A CDKAL1 RAB30 GPD2 TMEM59 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 RAB5C CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP NPRC GAS2L1 SAC3D1 MCL1 CCND1 MPDU1 CD164 VCAM1 BRPF3 HMGA1 SLC4A10 TNFRSF10A NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 BCL6 TRPV6 UBE2S CHMP2A SRPRB MENT DKFZp761E1322 PICALM SLC25A1 DOCK5 ADPGK TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 PTBP1 SMAD1 DNMT3B TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 PPP3R1 UTP15 HSDL1 RBM19 SIGMAR1 ARID1A TXN2 NT5C3A RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 UNC93B1 NXN UHRF1 PLAG1 HSD17B12 MRM1 AURKB GNA13 DNAJB1 CAND1 PPP3CA POLR2C RAB23 TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT ABCF2 SLC25A22 PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 IRS1 MAPK12 MAPK14 TCL1A PPIF MTRR LPL RTN4 KIT PRKCI IQGAP3 DOCK7 RARS1 COL4A2 HEL-S-26 HEL-S-47e MAPK7 CDK6 E2F3 LAMC2 FGF2 P4HA2 NELFCD CDKN1A PPP2R5C PPIB BDNF CDKN1B MAP3K8 LAMC1 SMC1A C1QBP SUCLG2 TNFRSF10B ITGA2 SNAP23 PTPRF CAP1 ATAT1 SYPL1 TUBA1A FBXW11 GPAM DDX5 CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 ATP6V1F GFPT1 ATP6V0E1 CPNE8 VEZT SERPINE2 TMEM41B EHMT1 CLDN1 PWP1 ABCG2 DCAF7 RRP8 PNP DHX57 KRAS LOC541469 CHORDC1 RAVER2 MYB CIAO2A SEC62 GOLGA7 NOTCH2 CDK5RAP3 HOXA5 NOTCH1 BCL2 ARL10 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 OTULINL POM121 HACD3 MRPL20 BACH1 FXR2 COMMD9 TERT RDH10 GRPEL2 CEP72 KCNN4 VTI1B SNX6 SLC38A1 GSTM4 PHC2 HARS1 RAB27B BRI3BP PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B FERMT2 HOXD8 RNP24 RCOR1 CDKN1C NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MEOX2 MRC2 PANX1 COIL CHAF1A SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC ANXA2 MRPS24 ELOVL5 ATP2A2 ELMOD2 AP2A1 TMT1A AP3B1 PRPF40A RHOB SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN PTRH1 VAMP3 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG HEL-S-66 PTPA PURA NT5E PGRMC1 PPP1R7 USP1 SHOC2 TAF9B SRSF10 MPZL1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation TLR4 IL10 CCL11 TMPRSS2 IL12A FURIN IL2 HMGB1 IL4 IL18 IL6 GFAP IFNG CXCL8 IL1B MAPK1 TNF IFNA2 ACE2 TLR8 TLR7 IL1A TLR3 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling GSK3B IL7R IL2RG STAT1 STAT3 IL7 MAPK1 STAT5B FYN MAPK3 JAK1 BAD PTK2B JAK3 MAP2K1 MAP2K2 PIK3R2 PIK3R1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 KLKB1 BDKRB1 SERPING1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development ID2 ASCL1 ID4 MBP MYT1 SOX8 SOX6 NFIA SOX5 NKX2-2 EGR2 BMP4 SHH NKX2-6 PDGFRA OLIG1 OLIG2 SOX10 MYRF CHD8 PTN ZNF24 SMAD1 NFATC2 DUSP15 SOX2 NKX6-1 SOX9 ZNF488 LGI1 OPALIN SOX11 ZBTB33 ZEB2 BMP1 TMEM98 CNTN1 CSPG4 WNT10A FGF2 HES5 TCF7L2 PRKCA RELN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 MTOR FOXO1 IGF1R NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC18A2 DDC MAOA SLC6A3 PNMT TH TPH2 DBH TPH1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 ALPL HEL-S-302 PLPBP ALPI HEL-S-1a PIGV DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CSNK1A1 FOXO1 CDK4 DCAF7 RPTOR DEPTOR MLST8 CRY2 NOTCH1 CDKN1B SIRT1 PSEN1 LIN54 NEUROG2 GMNN HES1 DNER AKT1S1 LIN52 RBL2 HES5 RBL1 TFDP1 TFDP3 AMPH LIN37 LIN9 RBBP4 E2F5 EIF2B5 REST CCND1 TFAP4 SPRY2 GSK3B CASP9 TSC2 APP CASP3 TSC1 NFATC1 E2F4 MTOR DYRK1A TFDP2 CDK6 FGF2 CREB1 H3F3B LATS2 PSENEN BACE1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK1 IRAK2 IRAK4 MAPK10 IRF7 SAFB MAPK9 TAB3 MAPK8 MYD88 RELA CHUK MBP TRAF6 MAP3K1 MAP3K7IP1 NFKB1 MYC MAP2K3 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB EIF4E RPS6KA5 MAP3K8 MAP3K7 FOS IL1R1 IKBKB MAPKAPK2 TANK IL1A GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 EGFR OTUD5 DGIC AHCTF1 LBR DSCC1 CHTF18 MTDH CHTF8 BRIX1 TOP2A RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 MYC RNF144B LMNB2 UBE2T SNURF S100A6 CD48 CEBPZ COL9A1 COL9A3 RAD17 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 ITGB1 SMAD2 HEL113 FLT1 RELA CXCL2 CDH2 VEGFA SNAI2 IGF1R DKFZp781O1323 SRC KDR SHC1 PDGFRA CTNNB1 CLDN1 PDPK1 SOCS3 RPS6KA3 SOCS1 PRKAA2 MAPK1 TNF MAPK3 CCL2 MAP2K1 MAPK14 MAP2K2 ACACA ZEB2 RAF1 RPS6KA4 SP7 RPS6 RPS6KA5 RPS6KB1 PRKCB IBSP HEL-S-133P HEL-S-102 GSK3B ACTA2 MAPK9 MAPK8 TGFB1 CSF3 PLCG1 IL10 COL4A1 JUN NFKB1 IL6 CXCL8 CRKL CPT1A BGLAP SIX1 SMAD1 CXCL5 HK2 MTOR DUSP4 CLDN5 SLPI PIK3R1 PCNA MST1R SMAD6 KLK15 PARP1 SMAD9 FZD1 FGFR1 WNT10B NR0B2 RPS6KA1 FOS PTEN IFNB1 TJP1 IL1B PPARGC1A CSF2 EGR1 GRB2 CXCL1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders HIST1H2BE TERF2IP TPP1 H2BC21 H2AC19 H2AX H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 ACD H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 TINF2 H2BC1 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H3-4 H2BC15 H2AC20 H2BC11 POT1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP FPGS UPP2 TDG TK1 RRM1 RRM2 ABCC5 GGH SMUG1 DHFR UCK2 UCK1 ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 XRCC3 CYP2A6 CES2 CES1 TYMS ABCC3 DPYD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination SOX8 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 WNT4 SRY RSPO1 AMH FGF9 SOX9 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway MAPK8 PAK1 CHUK STAT1 STAT3 WASL PDGFA MAP3K1 PLCG1 VAV1 VAV2 JUN SRC SHC1 NFKB1 MAPK1 MAP2K4 ARHA MAPK3 PTPN11 MAP2K1 NFKBIA COX2 PIK3R1 CDC42 RAF1 FOS RAC1 JAK1 HRAS TIAM1 GRB2 SOS1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease NOTCH3 HEL25 MEF2C HP1BP3 HSPB3 HSPB2-C11orf52 tmp_locus_29 LBR H2AZ1 LMNA ACTA1 MYOD1 MYOG DMPK AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 GLUD1 HAL GPT2 FTCD MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids PIK3CA CERS1 NFKB1 HIF1A ASAH2 TSC1 S1PR3 S1PR1 MTOR CERK SPHK2 IGF1R TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 MEF2C MEF2B CDKN2A CCND2 STAT3 BCL6 ID3 EZH2 IL21R NFKB1 MYC IL6 TLR5 TNFRSF13C BCR LYN TLR9 SYK TLR7 BCL2L1 ICOSLG CDKN1B CD40 SPI1 CD79B SPIB CCND3 CD79A POU2F2 TLR1 IRF4 POU2AF1 IRF8 TCF4 TLR10 TCF3 CDKN1A TLR8 TLR3 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD MAPK8 PAK1 STAT3 STRN ARAF NRAS BRAF CRK PLCG1 JUN ALK SRC PIK3CA RAP1A HGF AKT3 MAPK1 KRAS SOS2 CRKL MAPK3 MET BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 PIK3R1 CDC42 RAPGEF1 RAF1 CBL PIK3R3 CDKN1A PRCC RPL11 ELOA PAK6 RAC1 INSL3 PAK4 HRAS C8orf34 JAK3 GRB2 SOS1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R11 PPP1R10 PPP1R2 PPP1R8 PPP1R16B MAPK8 MBTPS1 PPP1R14A PPP1R14B PPP1R14C PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B HEL-S-89n PPP1R3E PPP1R1C PPP1CC PPP1R1B PPP1R3D PPP1R12B HEL-S-80p PPP1R14D PPP1R12C MBTPS2 DDIT3 PPP1R9A ERN1 BCL2 XBP1 EIF2AK2 MAP1LC3A PPP1R3A PPP1R7 EIF2AK1 EIF2S1 PPP1R15A PPP1R15B PPP1R13B ATF4 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOB LDLR APOE APOC2 LPL APOC3 APOA2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway FASN RXRA CYP3A4 NR1H3 CYP2B6 ABCG8 ABCG5 SCD CYP7A1 IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling IL9 IL2RG STAT1 STAT3 MAPK1 STAT5B MAPK3 JAK1 JAK3 MAP2K1 GRB2 MAP2K2 CDK9 IL9R PIK3R2 PIK3R1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway CDKN2A KLF4 CEBPA TREM1 CYP3A4 NFATC2 SLC2A4 ADRA1B CDKN1B TPM1 CD40 CDKAL1 IL25 IRF4 IRF8 IL12A NR1C2 HIF1A CCND1 TRAK1 TGFB1 ALOX5 BCL6 TRPV6 THBD BDKRB1 BGLAP SPP1 CYP7A1 GADD45A STEAP4 LPGAT1 CCNC GXYLT2 PRDM1 KNG1 CLDN2 SALL4 TNFSF11 LGALS9 EPHB4 SULT2A1 KRT71 SLC34A2 CCNE1 S100A2 ABCB1 MED9 CYP1A1 LCE1F LCE1D LCE2B CDC34 NINJ1 S100A4 S100A9 S100A8 TNLG2B COL13A1 CLEC16A KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 FGF23 HLA-DQA2 HLA-DQA1 KL SLC37A2 KRTAP12-2 KRTAP8-1 BMP6 CYP2S1 ID4 TRPV5 PNOC ID1 CLPTM1L STS MXD1 ALPG ZNF257 FOXO1 SPRR1B SFRP1 CD200 HLA-DRB1 ORM1 HILPDA TNFAIP3 MYC CYP27B1 ORM2 ADAMTS5 CDK2 SULT1C2 RXRA CASP14 DUSP10 NR1i1 ADGRE5 CASP5 DACT2 TIMP3 ATP2B1 CTLA4 SOSTDC1 KRTAP5-1 CA9 ABCD1 SLC8A1 CAMP HNF1A KRTAP5-4 KRT34 CEACAM1 CYP2C9 KRT38 DEFB4B CYP2B6 COLEC11 SATB1 TNFRSF11B PTH ALPI HEL57 IGFBP1 SEMA3B ASAP2 IGFBP5 CST6 PTHLH DNER IL1RL1 JUNB CST1 CLMN CREG2 HSD17B2 CDKN2D LRRC25 S100G KRTAP10-2 CDKN2B KRTAP10-4 PRKCQ CDKN2C CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CYP24A1 KRT16 CD9 CBS LRP5 EFNA5 S100A6 ITGAM ADRB2 CDKN1A PTGER4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins PLCB4 TERF2IP PRKCZ MAPK9 CADM1 CSN3 GRIK2 GPHN CDH2 RAP1GAP CHL1 EPB41L3 NCDN CAMK2G MAP4 NEO1 CLASP1 GRIN1 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 EFNA5 GABRG2 SNW1 DAB1 AGRN ATP2B1 KCNQ2 KCNMA1 CASK STX2 GRIN2B MAPK4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PPARGC1A SIRT1 IGF1 PRKAB2 MTOR EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling MEF2C CAMK2A RPS6KA2 MEF2D GAB2 VAV1 NEDD4 VAV2 SRC SHC1 PDPK1 ERBB2 EIF4EBP1 SOS2 PTPN11 COX2 EGF INPPL1 CBLC RPS6KA5 GRB10 RPS6KB1 STAT5B PTK2B MAP4K1 MAPK9 MAPK8 STAT3 ARF6 MAP3K2 RAP1A CRKL INPP5D PIK3R2 PIK3R1 PTEN RAC1 JAK1 HRAS RALA EGFR PAK1 STAT1 BRAF MAP3K1 FOXO1 RPS6KA3 JUND MAPK1 KRAS ATF1 MAP2K1 MAPK14 MAP2K2 RAB5A RAF1 GJA1 PRKCB PRKCA PRKCI SPRY2 HEL-S-15 MAP2K5 PRKCZ CRK PLCG1 ROCK1 JUN MAPK7 CAV2 SP1 USP6NL SH3GL3 ERRFI1 MTOR NDUFA13 PLCE1 SH3GL2 STXBP1 RALBP1 PCNA CDC42 HGS STAMBP RIN1 STAM2 SH2D2A AP2A1 IQGAP1 FOXO4 PLD2 ATXN2 TNK2 PIK3C2B PTK6 CBL SYNJ1 AP2S1 RPS6KA1 HEL-S-34 PXDN NCK2 NCK1 VAV3 EPS15L1 FOS EPN1 AP2M1 PLSCR1 ARHGEF1 RALB CREB1 ASAP1 NEDD8 MAPK4 REPS2 RICTOR CSK LIMK2 GRB2 ITCH FOSB SOS1 PTPN5 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 CALM1 PDE3B RYR2 ADCY3 ADRA1B MYLK ADCY1 ADORA2B ADCY8 ADRA1A PDE4A ADCY6 PDE3A RYR3 ADRA1D PDE4B PDE4D HEL-S-80p PPP1R12C ADCY9 ADORA2A NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation ITGB1 HDAC2 HDAC10 HDAC11 DMBX1 ASCL1 CDH6 MPZ CDH2 ZIC1 MBP HOXA1 ID1 FOXD3 SNAI1 SOX5 MSX2 SNAI2 MIA BMP4 OLIG3 PAX3 ISL1 DCT OLIG1 PAX7 CTNNB1 OLIG2 HAND1 HDAC5 MYC SOX10 HOXB1 CTBP2 HDAC8 GFAP DLX5 HDAC9 TWIST1 HDAC7 HDAC6 PRTG GBX2 MSX1 TFAP2A MYB TFAP2B ZIC5 TBX6 NOTCH2 PHOX2B NOTCH3 GJB1 NOTCH1 TLX2 LHX1 PMP22 BMP7 LHX5 NEUROG1 FGFR2 HDAC1 HES1 TCF4 DVL1 HES5 FGF8A DVL2 DVL3 TCF7L1 NFKB2 COL2A1 WNT1 COL11A2 WNT3A GSK3B AXIN1 AXIN2 NFKB1 RBPJ SMAD1 FGF8 SOX9 FGFR1 RHOB FZD3 HEY2 FGF2 WNT8A DLL3 DLL4 HDAC3 FGFR3 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN1 GRIN2B DLG4 NLGN1 GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 NLGN3 NLGN2 NRXN1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCB4 PLCH1 PLCH2 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 PIP4K2A PLCG2 PLCG1 PIK3CA MTMR10 INPP5D PIK3R4 PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 IL2 SPN CD27 CD3G CD3E CD3D CD80 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 RAD9A CDKN2A CASP9 CASP3 BAK1 TP73 APAF1 BAX YAP1 MRE11A MDC1 TRAF6 RIF1 SMC3 KAT5 TRIM28 HSF1 RAD50 TP53BP1 RAD51 BLM ACTL6A RASSF1 NABP2 MCPH1 ATF2 FANCD2 PCNA PRKDC PARP1 H2AX MDM2 ATM NBN ATR SMC1A RNF8 BRCA1 TERF2 LATS1 BRCA2 RAD52 CDK5 CHEK2 RAD17 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production HMGCR FDFT1 PDIA2 DGAT1 APOA5 SQLE APOC2 APOC3 SOAT1 ABCG8 APOC1 ABCG5 CYP7A1 LIPC APOA2 ACSS1 APOA4 SCARB1 MTTP APOB LDLR PLTP APOE LPL ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EP300 ACKR3 HGF CYP2C19 CYP3A7 NRG1 CYP3A4 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 AHR CYP4F12 ACOX1 CCND1 IL2 APOA5 GCC1 TNS4 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 MGST1 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 ABCB4 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 CYP1A1 SLC19A2 SLC2A3 GSTM3 PLK2 ABCC3 SMARCA1 SLCO1B1 HEL-S-128m SLC6A5 SLC6A7 ABCB11 SLC6A8 SLC6A9 DNAJB1 CPEB4 GSTM5 SLC6A1 SLC6A2 EPB41L4B ENC1 ANKRD1 TGFBR2 NCOA1 SLC2A14 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 EGFR SLC2A10 TSC22D3 SLC2A13 PTGS2 SLC2A12 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 BAAT POU5F1 SLC7A5 B3GNT5 CDC42EP3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF NR1I3 FGD4 TNF SRPX2 GPR153 SERTAD2 CAP2 CCL20 CAVIN2 PTGES3 GSTM2 NR1i2 NR1H4 CYP8B1 KTN1 FASN FABP1 GSTA5 GSTA4 SLC27A5 GSTA3 SLC6A3 SLC27A1 CDC37 NR3C1 SLC39A9 UGT1A1 EPHA2 SLCO2B1 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 DNER SLC39A3 AIP ALDH3A1 FGF8A SCNN1A FKBP5 NFKB2 SLC26A2 ABHD2 IP6K3 DNAJC15 SLC2A9 ALAS1 SRXN1 SLC2A6 SLC2A7 SLC2A8 ARL5B CPT2 ZIC2 ME1 PDK4 POLK ACADM SRGN GPX2 HEL-S-25 HEL-S-22 TGFBR3 DNAJC7 NAV3 ADGRF4 BIRC2 BIRC3 SLC5A12 SLC5A10 PRRG4 UGT1A4 STOM UGT1A7 TXNRD3 S100P SPRY1 ADH7 PCK1 KLK15 FGF13 HSP90AB1 ABCC5 SRC DBI CCL2 APOA2 PLTP CDKN1B IL12B SMC1A IL12A IFNG GADD45B CDC2 IL17B TGFB1 STAT3 PPP1R14C BAX ALOX5AP TXN SERPINA1 THBD APOC3 CPT1A ABCG8 ABCG5 SCD CYP7A1 GPAM SULT2A1 CYP1A2 CYP1B1 NR0B2 ABCB1 BHLHB2 SLC2A2 SLC5A1 SLC5A2 SLC6A20 SLC5A5 PPARGC1A EGR1 UGT2B4 SLC6A19 UGT2B7 ABCC2 SLC6A18 GSTM1 SULT1A1 SNAI2 SLC5A8 FOXO1 CDK4 TNFAIP3 NR1C1 MYC IL11 RXRA JUND NR1i1 HEL-75 GCLC NFE2L2 CYP2C9 RGS2 CYP2A6 CYP2B6 EHHADH IGFBP1 HES1 JUNB SLC7A11 FTH1 NR1H3 SLC39A8 GSTM4 KAT2B KEAP1 MAFG SLC39A14 FTL CDKN1C JUN HMOX1 SP1 MAFF GCLM PDE4B AMIGO2 PTPA IL1B NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling GSK3B HDAC2 EP300 STAT3 SKP1 SRC NFKB1 MAML2 SNW1 MAML1 FHL1 DTX1 RBPJ MAGEA1 CIRSR MTOR SPEN PIK3R2 SAP30 NCOR1 NOTCH2 PIK3R1 HES6 NCOR2 NOTCH3 NUMB NOTCH1 APH1B FBXW7 ADAM17 MAML3 JAG2 PSEN2 HDAC1 PSEN1 HEY2 HES1 DLL3 HES5 DLL4 PSENEN ITCH LCK DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MARCHF5 DNAJC19 TIMM8A TIMMDC1 USP9X STAT2 PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 C1QBP AIFM1 MCL1 TRAK1 MFN2 PARK2 VCP UFD1L MIPEP UBXN1 CLPB TXN2 PLEK FLJ10842 MICOS13 OPA1 OPA3 GDAP1L1 TXNRD2 LONP1 SACS PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CDKN2A RELA ZAP70 IRF2BPL GRAP2 HLA-DRB1 TYK2 LTA PDPK1 LCP2 CARD11 BCL10 CCL19 MAPK1 PTPRC TNF HLA-DRA FYN MAPK3 CCL28 LAT RPTOR IL18R1 MAP2K1 NFKBIA DEPTOR CTLA4 MAP2K2 MLST8 BCL2L1 RAF1 CD80 RHEB IL12B IL12A IFNG IL23A PRKCQ CCND1 LCK IL17A GSK3B IL23R PIK3CD TSC2 MYD88 CD3G CD3E CHUK TSC1 CD3D BAX STAT4 IFNAR2 IKBKG PLCG1 IL12RB1 JUN NFATC1 IFNAR1 NFKB1 IL2 IL4 MTOR PIK3R1 ICOS FOXO3A FOS CDKN1A PTEN IFNB1 IKBKB PPP3CC RICTOR HRAS GRB2 SOS1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG2 PRKAG3 PRKAA1 RHOB YAP1 RHO HMGCR CTGF PRKAB2 PRKAB1 LATS1 TEAD4 CYR61 PRKAA2 LATS2 ARHA STK4 TEAD2 RHOD TEAD3 MOB1A PRKAG1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 ACE2 AGTR1 AVPR1B ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer EGFR BAK1 NRAS BRAF CTNNB1 PDPK1 MYC AKT3 ERBB2 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 HEL-S-28 CTNNA1 CTNNA3 EGF RAF1 CTNNA2 FGFR2 LEF1 DDB2 PIK3R3 TCF7L2 TCF7L1 GADD45B GADD45G CCND1 GSK3B PIK3CD POLK CASP9 ARAF BAX AXIN1 AXIN2 PIK3CA BAD GADD45A APC PIK3R2 PIK3R1 FGFR1 FOXO3A FGF2 FOS CDKN1A PTEN HRAS APC2 GRB2 SOS1 FGFR3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 STAT2 MYD88 CHUK STAT1 TRAF3 TRAF6 TBK1 IFNAR2 IKBKG JUN TYK2 NFKB1 IFNAR1 MAVS RIGI MAPK14 NFKBIA TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 RIPK1 MAP3K7 FOS TICAM1 IKBKB JAK1 IFIH1 IRF3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDKN2A EGFR SMAD2 SMAD4 PAK1 BAK1 RELA STAT1 BRAF VEGFA TGFBR1 RAD51 CDK4 AKT3 ERBB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 TGFA BCL2L1 EGF RAF1 RPS6KB2 dik RAC3 E2F2 RPS6KB1 DDB2 PIK3R3 RB1 PAK6 PAK4 GADD45B TIAM1 GADD45G CCND1 PIK3CD MAPK10 POLK CASP9 MAPK9 MAPK8 TGFB1 CHUK STAT3 ARAF BAX IKBKG PIK3CA NFKB1 ARHA BAD MTOR GADD45A PIK3R2 PIK3R1 RALBP1 CDC42 CDK6 E2F3 HEL-S-34 CDKN1A RALB BRCA2 IKBKB RAC1 JAK1 TGFBR2 RALA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 IDO1 GOT2 IFNA6 KYAT3 KYAT1 IL6 DDC IFNB1 IFNG AADAT IL1B HAAO TNF KMO KYNU AFMID IDO2 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development MEF2C NKX2-5 SMAD4 FOXC2 FOXC1 VEGFA BMP4 SHH NFATC1 ISL1 PITX2 CTNNB1 FGF10 HAND1 GATA4 MAPK1 NFATC3 SMAD1 NFATC2 PTPN11 FGF8 NFATC4 ERBB3 NOTCH1 FOXA2 HEY2 BHLHB2 BMPR1A BMP10 GATA6 BMPR2 TBX20 SMYD1 TBX1 FOXH1 IRX4 TBX5 TBX2 HAND2 BMP2 VEGFB VEGFC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 LAMB3 LAMB2 PTGS2 BAK1 RELA TRAF3 CDK4 MYC AKT3 RXRA CDK2 NFKBIA NFKBIB BCL2L1 BCL2 CDKN1B ITGA2B E2F2 LAMC1 DDB2 CCNE2 PIK3R3 RB1 CKS1B CDKN2B GADD45B ITGA2 TRAF1 TRAF4 COL4A3 GADD45G CCND1 TRAF5 CKS2 CYCS RARB COL4A5 BIRC7 PIK3CD FHIT POLK RXRB CASP9 LAMA5 RXRG LAMB4 CASP3 CHUK APAF1 BAX TRAF2 TRAF6 IKBKG COL4A2 BIRC2 CDKN1C COL4A1 BIRC3 SKP1 COL4A4 PIK3CA COL4A6 NFKB1 MAX CASP8 NOS2 GADD45A PIK3R2 PIK3R1 LAMB1 CDK6 E2F3 LAMC2 CCNE1 ITGAV CDKN1A PTEN IKBKB ITGA6 LAMA1 LAMA4 LAMA3 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MMP9 MEF2D EZH2 SHC1 TWIST1 SOS2 PIK3R3 HIF1A COL4A3 COL4A5 MAPK8 SPARC TGFB1 TUSC3 HEL-S-79 FOXQ1 FZD10 CDKL2 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 JUP PALS1 VTN NRP2 PKD1 CLDN22 CLDN20 CLDN24 CLDN23 EED CLDN11 CLDN10 CLDN15 PIK3R2 CTDSP1 PIK3R1 CLDN14 CLDN19 STRAP CLDN4 CLDN18 CLDN2 CLDN17 CLDN16 TMPRSS4 FZD1 NR2C2 WNT10B SUZ12 WNT10A GDF15 FZD3 NUBPL CRB3 FZD2 FZD5 FZD7 FZD9 FZD8 TJP1 MMP2 LATS2 HRAS TGFBR2 MMP15 SMAD2 SMAD4 PAK1 ID2 CDH2 FOXC2 ID1 SNAI1 FMNL2 SNAI2 FOXM1 TGFBR1 WNT7B WNT7A CTNNB1 CLDN1 AKT3 MAP2K3 MAP2K4 MAPK1 MAPK12 KRAS MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 RAF1 ZEB2 PROX1 WNT1 WNT3 WNT4 RBBP4 WNT3A GSK3B WNT2B PIK3CD TRAF6 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA LRP5 CLDN6 LRP6 RBPJ CLDN5 JAG2 FZD4 WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 GRB2 SOS1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 CYB TTC19 UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MAP1B BIRC5 TUBA2 MYH9 ERG EGFR SMAD2 STUB1 MAPRE1 AURKA HEL113 CFTR HDAC11 ITIH4 EP300 NEDD9 HTT KALRN ATXN3 ADRBK1 EP400 CCDC141 SHH POU5F1 FUS BDNF MIIP TARDBP ARID3A ISG15 BBIP1 CTNNB1 GARS1 CNOT6 HEL-S-2a HDAC9 TWIST1 MAPK1 HDAC6 MAPK3 MAP3K5 HEL-S-44 CYBB BCL2 GRIA2 NR3C1 PXN PRKCE MAP1LC3A SQSTM1 OPTN HIF1A HEL-S-102 PTK2B HEL-S-32 MIF GSK3B DCTN1 PRKCZ MAPK8 RHOT1 MYD88 BAX PARK2 KAT5 VCP HSF1 CSNK2A2 FOXP3 TUBA1C DLG4 SP1 SGK1 CSNK2B VHL APC TUBB HEL-S-72p APOE TUBA4A HEL-S-67p GSK3A SNCA HSPA4 DLG2 RAC1 IKBKAP CDC20 FREP1 SNCAIP CD133 FAT10 SIRT2 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EGFR PRL CHUK CEBPA PRLR NFIA CEBPB TFPI2 MYC CSN2 ERBB2 NRG1 CLDN6 YY1 ERBB4 DLGAP4 PTPN1 USF2 TTC9 NR3A2 GJB2 GAL ERBB3 NFIB ELF5 BCL2L1 EIF4E ORAI1 PGR HDGFL2 USF1 EIF4G1 TNFSF11 TPM3 NR3C1 TNFRSF11A STAT5B CCND1 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 CDKN2A SUMO1 TNFSF10 TP73 BBC3 OTX2 BAX BOK MDM2 ATM CDKN1A MYC PMAIP1 GADD45A TP63 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 SP1 MAPK1 MAPK3 RBPJ TLR9 CYBB CDC42 NOTCH1 NCF2 DOCK6 CYBC1 NCF1 NOX3 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 KCNN3 C4orf54 DLL4 GTF2I BEND6 EFL1 CYBA SHCBP1 RAC1 IBTK ARHGAP31 EIF6 SBDS BTK TLR8 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ADCY3 ADCY8 SLC16A10 SHH FOXO1 SRC KDM1A CTNNB1 AKT3 RXRA MAPK1 ATF2 RPTOR MAP2K1 MAPK14 MLST8 NOTCH1 RAF1 ITGB3 RPS6KA6 RPS6 RPS6KB1 RHEB AKT1S1 WNT4 THRA AQP7 GSK3B TRH TTF2 TTF1 NPPB ITPR2 MC4R CASP9 NHSL1 TSC2 DUOXA2 SLC16A2 TSC1 TBC1D4 TSHB ACTL6B SECISBP2L DIO1 SIRT6 SLCO1C1 ADRB3 PAX8 PIK3CA MAPKAPK3 ZNF516 PLIN1 PFKFB2 MGLL KDM3B AgRP UCP1 NR1A2 PRDM16 DUOX2 DEHAL1 NPY BAD MAFA FGF21 TSHR MTOR TG SLC26A4 TPO PNPLA2 POMC PPARG FGFR1 MDM2 ITGAV CREB3 FRS2 SLC5A5 PPARGC1A HRAS GRB2 SOS1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK10 MAP2K5 MAPK9 MAPK8 RPS6KA2 CSNK2A1 PIK3CA AKT3 MAP2K3 EIF4EBP1 MAPK1 MAP2K4 MAP2K6 MAPK3 RPTOR MAP2K1 MAPK14 MTOR MAP2K2 PIK3R2 EIF4A2 PIK3R1 EIF4A1 PIM1 EIF4E PIM2 EIF4B RPS6KB2 EIF4G1 RPS6KA4 RPS6 RPS6KA5 RPS6KA1 RPS6KB1 PIK3R3 PRKCA THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK9 MAPK8 RELA STAT1 STAT3 RELB STAT4 GAB2 SRC NFKB1 EIF4EBP1 MAPK1 FYN MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA LYN MAP2K2 TEC YES1 IL7R TSLP FES CRLF2 RPS6 NFKB2 JAK1 STAT5B BTK LCK SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida MAT1A MTRR MTR AHCYL2 MTHFD1 SHMT1 DNMT3B 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome SLC35G3 RPL23 SRCIN1 SLFN12 CACNB1 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 TCF2 SLFN5 CCL13 GRB7 CCL11 GGNBP2 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 CCL5 ERBB2 CCL7 ZNHIT3 LYZB C17orf78 CCL2 CCL4 CCL1 ASIC2 TEC CCL18 RFFL GAS2L2 SOCS7 ACACA CCL16 LHX1 HEATR9 CCL15 TAF15 TMEM132E RASL10B PCGF2 SYNRG EPOP FNDC8 PEX12 PLXDC1 NLE1 ARHGAP23 TBC1D3K STAC2 TCAP CDK12 SPMAP1 PIP4K2B PNMT PPP1R1B DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I MRM1 AATF IKZF3 MMP28 CISD3 DUSP14 TBC1D3H CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 UNC45B MED1 CCL3 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 HEL-S-130P PDX1 CTNNB1 MSRA GATA4 MAPK1 MAPK3 NKX6-1 SLC2A4 RAF1 BMP1 MTMR8 MTMR9 NUMA1 MTMR6 TERT PINX1 HEPACAM2 TBX5 SOX7 SLC35G5 PRSS55 NEIL2 BLK CSTA MCRS1 TNKS PRSS51 S100A10 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 FAM167A FCGR2A FCGR2B AXIN1 XKR6 PPP1R3B FDFT1 CLDN23 SLBP ERI1 TERF1 SGPL1 CGAS HSPD1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA VEGFA ERBB4 MGRA ADAM10 SMC1A MAT1A BMP2 SH2D4B FAM25A BUB1B SMC3 ADIRF LDB3 GHITM IQUB WAPAL NFKB1 ROPN1L RSPH6A ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 SH3GL3 DYDC2 DYDC1 ZMYND11 RGR RSPH9 PDS5B PDS5A GPR15LG RAD21 SNCG TNFSF11 GPR15 PPARG SUSD2 RSPH3 GLUD1 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 BMPR1A LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 OPN4 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 RPE PRPS1L1 DERA OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP9 CNTF CXCL2 CCL14 CCL13 CCL23 CCL11 CCL3L3 LIF LTA CX3CL1 CCL8 CCL5 CCL19 CCL7 CCL28 CCL2 CCL4 CCL1 CCL18 CCL16 CCL15 IL25 IFNA6 IL12B TNLG7A IL12A IFNG IL23A IL17F IL17D IL17C IL17B IL17A IF2B1 IL15 IL-21 TGFB1 CXCL12 IL10 IL13 IL2 IL4 IL5 CXCL8 SPP1 IL3 IL9 CSF2 MMP3 IL1RN CXCL17 CXCL13 IF2D CXCL11 CXCL14 IF2G IL36A IL1A IL36B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 EBI3 IL36RN IFNA21 IF1AA9 TNFSF13 IL36G PPBP VEGFA IFNW1 IL1F10 CXCL6 IL24 IF1IB1 IL27 CXCL3 IL7 IFNA8 CSF1 PF4V1 IL11 IL19 XCL2 TNF IFNK XCL1 CTF1 IFNL2 IFNL3 CCL17 CCL20 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 IFNA7 OSM CSF3 EPO NFKB1 IL6 IFNA2 CXCL5 TSLP CXCL16 CCL4L2 IL18 IFNB1 IL1B CXCL9 IFNA1 CXCL1 AREG CCL3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 FADD CASP9 CASP3 BAK1 APAF1 DIABLO BAX TNFSF6 CASP6 PRF1 FAS HTRA2 CASP8 AIFM1 CYCS TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors EIF1AX EEF2 EIF2S2 SUI1 EIF3S3 EEF2K EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF4EBP1 EIF4A2 EIF4A1 EIF4E EIF4B EIF4G1 GSPT2 EEF1B2 EIF4H EIF4EBP2 EIF4EBP3 EIF2AK2 EIF2B1 PAIP1 EIF5A EIF5B EIF2B3 CLUH EIF2B2 EIF1AY EEF1A1 EEF1G EIF2AK1 EIF6 EEF1A2 EIF2B5 ETF1 EIF2S1 PABPC1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E PIK3CD RAF1 TSC2 PRKAA1 TSC1 PIK3CA PIK3R3 MAP2K3 EIF4EBP1 MAPK1 MAP2K6 MAPK3 MAP3K5 MAP2K1 MTOR MAP2K2 HEL164 PIK3R2 MAP3K11 PIK3R1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y2 DUX4 MYF5 EP300 VEGFA PAX7 TRIM63 ADRB2 CDKN1A MYC FBXO32 PPARGC1A NR3A2 MYOD1 MYOG RET H3Y1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation TAF5 MIXL1 HOXA1 EZH2 PAX3 RGS10 CTBP2 GATA4 ZIC5 LHX1 ELAVL1 SESN1 LAMC1 GATA6 TCF4 C1QBP FOXH1 SOX7 PLCH1 APP TGFB1 TBX21 CRTC1 PIAS1 NABP2 DKK1 DNMT3B MAD2L2 BMPR1A NKX2-1 CAND1 SIAH2 SMAD2 SMAD4 SLC2A12 STAT1 TET1 TCF2 FOXO1 POU5F1 SFRP1 CUL4B CTNNB1 MAP2K3 SOX2 FOXA1 NOTCH1 ACACA BMP7 OTX2 FOXA2 NR3C1 LEF1 PTHLH TCF7L1 WNT3 PABPC1 WWC1 SOX21 SOX17 CEP250 CER1 WDHD1 SFMBT1 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF CEBPZ ATP8B2 PBX3 FOXN3 GDF3 DUSP4 APC ZFHX4 TRERF1 PBX1 EXT1 SP4 PAF1 TAF4B NODAL TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 JARID2 DUSP5 VAV3 DUSP2 WNT8A NOG PARP8 NR1B3 TOX3 AEBP2 Pax9 AHDC1 BTAF1 TCEAL2 LEO1 KDM4A ZNF462 ELP4 LRPPRC TNRC6C ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway PLAGL1 EGFR CD36 KLF6 NCOA7 PTGS2 RELA EP300 NRAS VEGFA SRC NFKB1 AHRR MYC CDK2 MAPK1 TNF KRAS FGF21 CCL1 MAP2K1 NCOR2 GCLC RAF1 NFE2L2 CDKN1B LPL NQO1 CYP1A2 NF1 CYP1B1 CDC37 CYP1A1 AIP CDKN1A RB1 HRAS AHR RET GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG INS IL6R IL6 GLP1R SLC2A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP INSR STAT3 LEPR INS PDPK1 PIK3R3 SOCS2 DGKZ SOCS3 SOCS1 IRS1 IRS4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 REN MGRA ACE2 AGTR1 DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SCN8A PRR5 MAPKAP1 KCNA2 CHD2 PCDH19 SCN3B SCN3A SCN1B SCN1A PIK3CA SNTA1 NFKB1 SCN2A SCN4B SCN2B HCN1 TNF MAPK11 MTOR STXBP1 MLST8 CALM1 FGF13 PRKCA RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB1 PLCB2 GNAI1 S1PR3 PIK3C2B GNAI3 SPHK2 SPHK1 MAPK7 PLCB3 AKT3 MAPK6 SMPD2 MAPK1 S1PR2 MAPK4 MAPK12 S1PR5 MAPK3 S1PR1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MEF2C CAMK2A TET2 CNP CTCF TET1 MBP EZH2 IGF1 FUS IGF1R CEBPD BDNF TARDBP GRIN1 DLX5 PSIP1 YBX1 CDON RBFOX1 HEL-S-20 TAP1 NCOR1 POU3F2 HNRNPH1 GPRIN1 TET3 DLX6 FOXG1 NREP FUT8 PRPF38A RPS6 GAD1 HDAC1 GRIA3 IGF2 GRIA4 POU4F1 SST HNRNPF TAF1 FKBP5 REST SP3 BCL6 MYT1 SMC3 UBE3A SP1 SGK1 APOC2 MTOR OPRK1 NF1 FGF2 FGF7A PTEN CREB1 FGF5C SIN3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SC5D DHCR7 HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB COL5A3 COL5A2 LAMB2 COL3A1 ITGB5 COL4A2 COL4A1 LAMC1 ITGB6 THBS1 SDC2 ITGA1 COL6A1 LAMA4 COL1A2 THBS2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling GSK3B PDHA1 CYP24A1 TSC2 TSC1 RELA CD80 IL10 SLC2A3 PIK3CA IL12A MYC PFKFB4 HEL-S-133P RXRA PRKAA2 NR1i1 HK3 HLA-DRA MTOR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling CIP2A RGMA DCSTAMP MYF5 COL1A1 CASP3 YAP1 CTGF IL10 JUN NEO1 SRC PIK3CA KDR AGAP2 MAPK1 TNF ARHA FYN MAPK3 INPP5D CCL2 PTPN11 MAP2K1 MAPK14 MAP2K2 SELE PPP2R1B RAF1 ALPL ITGB4 PRKCA PTPA RAC1 ROBO4 NTN1 PTK2B RLF NTN3 PLEKHH1 ARHGEF12 VCAM1 UNC5B IL1A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5 NRF CD8B1 CD3G PRG3 CD3E CD2 IGLL1 CD8A CRP LBP ZAP70 MMP25 HLA-DRB1 IL6 CXCL8 HLA-DRA FYN LCK FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia EGFR MRE11A DCLRE1B CTDP1 UHRF2 FAAP24 CEBPD BRIP1 RAD50 SLX4 RAD51 MEN1 FANCM CENPX FANCL REV1 UBE2T FANCA FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C FANCD2 RFWD3 ERCC1 HEL-S-125m CENPS MCM2 SMARCA4 FAN1 MAD2L2 ATM NBN ATR UHRF1 PTEN BRCA1 BRCA2 USP1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IRAK1 PDLIM7 MAPK8 CHUK RELA TRAF6 IKBKG MAP3K7 NFKB1 TRADD NFKB2 IFNB1 CXCL8 IKBKB CCL5 MAPK1 TNF MAP3K14 TRAF1 NFKBIA CCL20 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA MAFG FBL CREBBP IRF2 SMAD4 HEL23 DDX21 CREB1 FOXO1 NPAS2 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling MEF2D STAT1 TRAF2 MAP3K1 TGFBR1 SHC1 MAX MYC MAP2K4 DDIT3 MAP2K6 MAP3K5 ATF2 MAPK14 SMIM40 CDC42 RASGRF1 HMGN1 MAPKAPK5 RPS6KA5 RIPK1 MAP3K7 TRADD CREB1 RAC1 HEL-S-102 HRAS GRB2 MAPKAPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHS1 ACSL5 ACSL3 ACACA FASN PECR MECR PC ACSS2 ECHDC1 ECHDC2 DECR1 ACLY ACACB SCD ACSL1 ACSL6 FACL4 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway MASP2 HEL-S-62p C3AR1 FCN1 C6 C7 COLEC11 C9 ACE2 C5AR1 C8A ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP IL2RG CRLF2 STAT3 IL25 FCER1G IL13 IL1RL1 FCER1A TYK2 MS4A2 IL13RA1 IL4 IL5 OSMR JAK3 IL33 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways MAT1A NNMT TPMT INMT PNMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ME1 BCAT2 HMGCR PFKL ACLY SLC7A5 DLD SOAT1 KRAS HEL-S-30 HK2 GNPNAT1 PDHA1 LDLR GOT2 FASN CS GLUD1 PDHX RPIA GLS2 RPE PGM3 HEL-S-133P DLAT GPT SLC16A4 CARM1 HEL-S-32 GFPT1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG2 PDHA1 ACACA FASN PRKAG3 PRKAA1 LIPE PRKACG ACSS2 PRKAB2 ACLY PRKAB1 HILPDA PLIN1 AKT3 PRKAA2 PRKAR1B PRKAR1A ABHD5 PNPLA2 PRKAG1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR4 IRAK4 IL2RG TGFB1 STAT3 CD80 TRAF6 NFKB1 IL4 NFKB2 SOCS1 CCL5 CCL2 TGFBR2 CTLA4 IL2RA TLR8 TLR7 IL2RB PDCD1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA PRKDC CHAF1B NASP MCM2 HAT1 ASF1A ASF1B H4C9 HIST1H4L CHAF1A RBBP4 SUPT16H XRCC5 SMIM40 SSRP1 CHEK2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP2A6 XDH CYP1A2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TLR4 MMP9 IRF7 CREBBP STAT2 EP300 EGR2 SRC TYK2 SOS2 NFATC3 NFATC2 NFATC4 IKBKE IFNA6 MAP3K7 DDB2 PIK3R3 STAT5B PTK2B JAK3 MAPK10 MAPK9 MAPK8 TGFB1 STAT3 ARAF BAX STAT4 NFATC1 CXCL8 CASP8 VDAC3 PIK3R2 PIK3R1 FADD IKBKB CASP12 JAK1 HRAS IFIH1 TGFBR2 IRF3 TLR3 IFNA13 BIRC5 IFNA14 IFNA16 SMAD2 IFNA17 SMAD4 IFNA10 TICAM2 HSPG2 RELA STAT1 IFNA21 DDX3X TRAF3 IF1AA9 CASP10 BRAF TIRAP NRAS DDB1 MAP3K1 TGFBR1 MAP3K7IP1 FAS MYC IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 KRAS MAP2K6 MAPK3 MAPK13 ATF2 MAPK11 MAP2K1 MAPK14 MAP2K2 BCL2 RAF1 CREB3L3 CREB3L4 TNFSF6 PRKCB IFNA7 TICAM1 PRKCA CYCS ATF4 IRAK1 PIK3CD IRAK4 CASP9 MYD88 CASP3 CHUK APAF1 TRAF6 TBK1 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD PCNA YWHAQ HEL-S-1 CREB3L2 FOS YWHAZ CREB3 CDKN1A IFNB1 CREB1 CREB5 IFNA1 GRB2 SOS1 ATF6B NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A5 MYH9 LAMB2 MYO1E SCARB2 SMARCAL1 CD151 HEL-S-47e PTPRO COL4A4 GPC5 APOL1 TRPC6 SYNPO YARS EMP2 ALG1 WDR73 COQ6 ARHGAP24 COQ2 PAX2 WT1 CD2AP INF2 NPHS1 CTLA4 CYP11B2 PLCE1 ACTN4 NPHS2 COQ8B LMX1B E2F3 ITGB4 ZMPSTE24 LMNA CUBN COL4A3 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 THRAP3 MORC3 ELL BCLAF1 SETX STK38 TRIM35 RBBP7 SUZ12 EZH1 EZH2 JARID2 AEBP2 RBBP4 EED COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 HEL-S-78p F13B PLG F13A1 FGA BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage TNC REN TCF2 BMP4 SFRP1 DKFZp781O1323 KDR PAX2 WT1 RSPO1 NPHS1 NPHS2 NOTCH2 NOTCH1 LHX1 HNF1A tmp_locus_29 BMP7 NR2A1 CITED1 TCF21 SALL1 SIX2 RSPO3 DACT1 EMX2 FOXD1 OSR1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 WNT4 TBX18 NTN1 GDNF TLX1 FAT4 DCN VSX2 ACTA2 EPO AXIN2 SIX1 SMAD1 FGF7 FGF8 PBX1 NT5E IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 IDO1 GOT2 IFNG AADAT TNF KMO KYNU KYAT3 KYAT1 IDO2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF PGR FOSL1 MYC HEL113 ERBB2 CCND1 TIMP1 AREG HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC RBX1 CBFB NAE1 UBA3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B PTPRN CAMK2A SCN11A PDCD10 SCN7A SCN8A SCN5A PRRT2 MAPK8IP2 SCNM1 SCN4A RNF121 NEDD4 SCN3B SCN3A WEE1 SCN1B SCN1A SCN2A SCN4B SCN2B TNF FYN FGF14 CALM1 FGF13 FGF12 PSEN1 SCN9A BACE1 SCN10A ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC5 CDKN2A BAK1 TRAF3 CASP10 FAS MAPK3 MAP3K5 NFKBIA BCL2L11 SMIM40 BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO PIDD1 TNFSF6 CASP6 RIPK1 AIFM2 IL1R1 PMAIP1 TNFRSF10B AIFM1 BLK PRKD1 MCL1 CYCS IRAK1 BIRC7 TNFRSF10A CASP9 MAPK8 MYD88 CASP3 APAF1 BAX TRAF6 HRK TNFRSF6B BIRC2 CAPNS1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 PTRH2 MADD TNFRSF25 NAIP BCL2A1 BCL2L10 CASP8 BAG3 MAP3K14 BMF CRADD BAD BIK BNIP3 TNFRSF10C SEPTIN4 PTPN13 TNFRSF10D BCL2L2 FADD FOS TRADD IKBKB TNFRSF1B HTRA2 IL1R2 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling CREBBP HDAC2 CTBP2 MAML1 DTX1 RBPJ NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 APH1B ADAM17 MAML3 RBPJL JAG2 CTBP1 DTX2 DTX3 PSEN2 DTX4 LFNG KCNJ5 HDAC1 DTX3L PSEN1 KAT2A MFNG HES1 DLL3 DVL1 HES5 DLL4 DVL2 DVL3 KAT2B METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX12 PTGS2 ALOX5 ALOX15 FADS2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 RPTOR MAPK11 MAP2K1 MAPK14 MAP2K2 PRKAG1 MLST8 PRKAG2 PRKAG3 PRKAA1 PRKAB2 RPS6KB1 PRKAB1 CDC2 EEF2 EEF2K MTOR CALM1 UQCRB COX7C RPS6KA1 RAB5IF MOSMO UQCR11 NDUFS8 UQCR10 CYB NDUFS3 COXFA4 CDH18 UQCRH COX5A UQCRQ TRPM7 UQCRC1 PDZD9 UQCRFS1 CDR2 CYC1 NDUFA9 SDR42E2 UQCRC2 VWA3A POLR3E FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 RPS6KB2 TSC2 FSHR RPS6 RPS6KB1 FOXO1 RHEB SRC PRKCA FSHB CREB1 EIF4EBP1 MAPK1 SGK1 MAPK3 H3-4 APPL1 MAPK14 MTOR CGA PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 BIRC5 PTGS2 RELA CHUK CXCL2 RELB TRAF6 VEGFA BIRC2 BIRC3 TNFRSF1A NFKB1 IL2 IL6 CXCL8 BCL2A1 TNF SELE BCL2L2 NFKB2 CD40LG IKBKB EGLN2 MMP2 IL1B CSF2 MMP3 REL CCND1 VCAM1 IL1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C8 NR1C1 PPARG CYP4F2 CYP4A11 CYP4F12 CYP2C18 EPHX2 CYP4A22 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C2 NR1C1 CD36 CYP2C9 NR1i1 NPC1L1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A ADCY1 ADCY8 GNAI1 ARAF PPP1R1A GRIN1 PPP1CC RAP1A HEL-S-80p MAPK1 MAPK3 GNAS MAP2K1 MAP2K2 GJB1 CALM1 RAF1 ACTG1 GRIA2 GRIA3 PS1TP5BP1 PRKACG GRIA4 PRKCB PRKCA DRD1 DRD2 CREB1 DRD4 ACTG2 CAMK4 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 UGT2B7 AKR1D1 AKR1C1 AKR1C4 AKR1C2 UGT1A10 CYP11B2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB4 PLCB1 CACNA1A PLCB2 GRIA2 GNA14 RYR3 HOMER3 CA8 GRIA3 GRIA4 GNA11 TRPC3 GNA15 PLCB3 ATP2B2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 NFKB1 TGFB1 RASGRF1 STAT3 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling GSK3B MAPK9 MAPK8 CASP3 RELA CHUK TRAF3 RELB TRAF2 BIRC2 BIRC3 JUN NFKB1 CTNNB1 MAPK1 TNF CASP8 MAP3K14 MAPK3 MAPK14 NFKBIA NFKBIB FADD RAF1 HDAC1 RIPK1 MAP3K7 TWEAK TRIM63 TNFRSF12A NFKB2 IKBKB RAC1 TRAF1 TRAF5 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP9 SMAD2 CACNB1 SMAD4 MCUB SCX TOMM20 SLN TGFBR1 SGCA CAPN3 TRPC1 TRDN STIM1 CASQ1 TNNI1 DMD CACNG1 PRKAA2 PLA2G2A TNF FKBP1A SSPN SNTB1 NFKBIA AGTR1 CYBB ORAI1 PPIF CACNA2D1 PRKAA1 MPO CACNA1F FGA HEL-S-78p CACNA1S MCU DAG1 ATP2A1 ITPR2 CASP9 TGFB1 PRG3 CTGF IL10 TRPC6 SLC25A5 NFKB1 TRPC3 IL6 SPP1 NOS2 ELANE RYR1 SIGMAR1 NOX4 MMP2 IL1B CAMK2D TGFBR2 IL1A CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2C TLX2 MEF2B KLF4 ID2 MEF2D STAT3 RUNX2 EZH2 PAX7 HDAC5 LEFTY1 TLX1 SOX2 TLX3 MYOD1 LEFTY2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway RAF1 MAPK8 STAT1 STAT3 MAP3K1 PLCG1 JUN PRKCB EIF2AK2 PIK3CA SHC1 FOS PRKCA MAP2K4 STAT5B MAPK3 JAK1 HRAS MAP2K1 GRB2 SOS1 PIK3R1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT2B MAPK10 MAPK9 MAPK8 WNT7B WNT16 WNT7A CTNNB1 LRP5 LRP6 ARHA INVS WNT5B NPHP3 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT9B FZD7 FZD9 FZD8 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A ID2 ARCN1 ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B FLT3 ZBTB16 PYGO1 BCL9 WIF1 SALL4 RARA RUNX1T1 LEF1 PML CSNK1A1 AXIN2 NR1C2 JUP CTNNB1 TCF3 DKK1 MYC LRP5 WNT1 LRP6 CCND1 APC SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK GPX2 RELA DIO1 JUN NFKB1 TXNRD3 SP1 GPX1 CTH FABP1 NFE2L2 RPL30 HEL-S-134P SELENOF GPX3 SELENOI TXNRD2 SELENOH SEPHS1 CREM SEPHS2 PSTK EEFSEC POU2F1 GPX6 FOS TRNAU1AP SELENOO SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SELENOW GPX4 SELENOV SELENOT SP3 MSRB1 SELS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias FECH UROD UROS HMBS CPOX ALAS1 ALAS2 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EGFR ADAP2 HOXA1 MAP3K1 RAD51 OMG MAPK1 MAPK3 SUPT5H BCL2 EGF CRY1 RAF1 RBBP7 EZH1 CCNA2 CCNE2 SDC2 MCL1 PER1 RTN4R HEL-S-15 RAD9A WDR48 NGFR HOXA9 H3C8 EXOC8 EXOC7 RFC2 MYT1 ARF6 POLRMT EXOC4 EXOC3 MAP3K2 EXOC6 ROCK2 RFC3 EVL RFC4 EXOC5 EXOC2 EXOC1 H3C15 INPP5A E2F6 RAB11FIP4 TEFM UTP6 LIMK1 MAVS ATAD5 ARHA RAB11A RIGI EED COPRS EVI2A CRLF3 EVI2B METAP2 PCNA TUBB SUZ12 NF1 CCNE1 JARID2 H4C9 ATR HIST1H4L NGF IFNB1 USP1 SYN1 SOS1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 LEP ACACA ADIPOR1 ADIPOR2 PRKAA1 CPT1A LEPR PRKAG1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 NUP107 NOTCH1 HCTP4 GATD3 KIF15 AURKA SMOC2 CENPF ESM1 RUVBL1 MYBL2 ECT2 KIF20B E2F7 TOP2A H4C9 UBE2C ACTL6A S100P CEP192 H3F3B LIN9 APC INO80D VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 F7 PROC AIFM2 NQO1 PROS1 VKORC1 UBIAD1 F10 F9 GGCX PROZ 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation DAG1 MAPK9 MAPK8 TRAF3 TRAF2 SGCA SNTA1 LINGO1 DMD ARHA SSPN SNTB1 CDC42 MIPEP SACS RTN4 C1QTNF9 SGCD ATXN1 SGCB SGCG TNFRSF19 C1QTNF9B SPATA13 RAC1 TRAF1 TRAF5 RTN4R TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling CREBBP NRAS MAP3K1 MAP3K7IP1 KSR1 TNFAIP3 SMPD2 MAP2K3 MAP2K4 MAPK1 TNF KRAS MAPK3 MAP2K6 MAP3K5 NFKBIA RFFL NFKBIB BCL2L1 RAF1 DIABLO CDC37 MAP3K8 RIPK3 MAP3K7 RIPK1 NFKB2 CYBA REL TRAF1 PPP2CA TANK CASP9 PRKCZ MAPK9 TAB3 PIG59 MAP4K2 MAPK8 CASP3 CHUK APAF1 BAX TRAF2 TBK1 IKBKG BIRC2 BTRC BIRC3 SKP1 JUN CSNK2A1 TNFRSF1A TXN NFKB1 MADD CASP8 MAP3K14 FBXW11 BAD PSMD2 PLK1 FADD TRADD IKBKB TNFRSF1B OTUD7B RAC1 PYGL HRAS KSR2 PTPRCAP NSMAF GRB2 NFKBIE SOS1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence CYP4F8 SLCO2A1 HEL-S-53e DPEP2 ALOX12 LTC4S NAT2 PTGS2 ALOX5 HEL-S-22 ALOX15B ALOX15 ALOX5AP GPX1 FADS2 MAPK11 EPHX2 PTGES3 FADS1 ELOVL5 SIRT1 HEL-S-298 HPGD AKR1B1 DECR1 PTGS1 CDKN1A RB1 PTGIS PRXL2B ALOXE3 ELOVL2 PTGES PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway WNT2B TF NTF4 FST CNTF FLT3LG KITLG TGFB1 INHBA GDF5 EPO PDGFA IGF1 VEGFA BMP4 SHH WNT7B ALK INS FGF10 CSF1R HGF DKK1 IL6 CSF1 IL11 LEFTY1 FGF8 TPO IL3 NOTCH1 EGF TNFSF11 NODAL FGF2 FGF7A NOG IL6R WNT1 KIT NT5E CXCR1 WNT3A FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IRAK1 TLR4 IRAK2 IRAK4 MYD88 TICAM2 RELA CHUK LY96 LBP TIRAP TRAF6 IKBKG SRC PIK3CA NFKB1 CXCL3 IL6 TNF ARHA NOS2 CCL2 SYK ITGAM PLAT PLG FGA IL12B FCER1G TICAM1 HEL-S-78p IFNB1 IKBKB REL TYROBP IRF3 CD14 TLR3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYS2 GYS1 HEL-S-19 PYGL AKR1B1 SLC2A2 GYG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BIRC5 SMAD2 SMAD4 PTGS2 BAK1 DCC BRAF MSH3 TGFBR1 CSNK1A1 CTNNB1 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 BCL2L11 BCL2 RAF1 BBC3 LEF1 RAC3 DDB2 TCF7L2 TCF7L1 PMAIP1 REL GADD45B NTN1 GADD45G CCND1 CYCS GSK3B MAPK10 POLK CASP9 MAPK9 MAPK8 CASP3 TGFB1 ARAF BAX AXIN1 TBK1 AXIN2 MSH6 JUN MSH2 EXOC2 ARHA BAD GADD45A APC CSNK1A1L FOS CDKN1A RALB RAC1 APPL1 APC2 TGFBR2 RALA PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1A2 CAMK2A PDE3B ADCY3 ADCY1 ADCY8 PDE4A ADCY6 PDE3A GUCY1B1 PDE1C PDE1B PDE1A HEL-S-7a GRIN1 PDE11A PPP1R1B PDE6D PDE6C PDE6A PDE8A PRKG1 PDE6H PDE6G PDE2A PDE10A PDE12 PDE5A PDE7B PDE7A ADORA2A PDE9A CHRNA7 PDE4B PDE4D GRIN2B DRD1 DRD2 CREB1 ADCY9 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway CERS5 PLPP1 ACER1 SPTLC3 CERS2 SERINC1 CERT1 ASAH2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 PPP2CA KDSR VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREBBP HLX TRPC1 KDR HEL-S-68p GATA2 ACKR3 PDPK1 PRKAA2 SHC2 MLST8 VPS39 EIF4E TPM3 ADAM10 RPS6 NCL RPS6KB1 PTMAP7 PLA2G5 PXN AKT1S1 ACACB SARS1 CAMKK2 SDCBP PTK2B CCND1 OCRL TBCA EIF3S3 HEL-S-162eP NFATC1 EIF3F EIF3D DKK1 RAP1A CXCL8 CYR61 RAB11A MMRN2 PIK3R2 PIK3R1 RAPGEF1 FADD MDM2 HEL-S-128m NOX4 TEAD4 PPP3CA MMP2 RAC1 HRAS ANXA1 MMP10 SLC2A14 MMP14 ABCF2 PAK1 PTGS2 RELA STAT1 VEGFA FAS CTNNB1 HMGB1 HBEGF MAP2K3 PRKG1 MAP2K4 MAPK12 MAP2K6 MAP3K5 GPX1 MAP2K1 MAPK14 MAP2K2 CYBB RAB5A ERN1 BCL2L1 ACACA RAF1 RPL5 HEL114 RPL7 RPL18A LUC7L UBAP2L CHAC1 EPHA2 EPHB2 RPS11 FGA IER5 EIF2A ACOT9 TMEM170A SND1 INPP4B HEL-S-78p hEMMPRIN KATNAL2 EWSR1 BIN1 TXNIP ALB RPL27 PRKD2 PRKCI RPL26 PPP2CA PFN1 PABPC1 EZR HEL164 ATP6V0D1 MAPKAPK2 CYCS FLII GIGYF2 GSK3B HEL-S-15 DHX36 XB MYO6 MICAL2 PRRC2C LARP7 SRPK1 CALU HYOU1 DHX29 FAF1 KCNC3 CRK CCDC124 ROCK1 SRP54 ROCK2 HBD SHB EEA1 PIK3CA CSRP2 TMSB4X RPLP2 CGNL1 SSR4 SSR3 FJX1 LIMK1 ENG ARHA KANK1 HEL-S-87p CRIP2 SLC7A1 MTOR APOLD1 FGD5 GPC1 FLNB NUMB CDC42 CCT7 BRD4 AAG1 PRKRA TFAM TAOK2 COPG1 FOXO3A GLUD1 FHOD1 ITGB5 CTNND1 PLOD3 RPL10A AMOT CBL EPRS1 tal-1 CCRL2 P4HA2 TMSB10 ITGAV DUSP5 TMOD1 TMOD3 SEMA6D DPM1 FARSB DOK1 DLL4 ARMCX1 RAB37 ADAM9 FRS2 ZNF555 DSC1 LRRC59 HTRA1 FUT1 GRB2 QK3 IGFBP7 ZC3H15 HEL-S-94n SDF2L1 MEF2C HEL-S-84 BMX TPP1 ITGB1 AFDN RCAN1 TFCP2 CNP NR4A3 SPIRE1 GRSF1 MAPKAP1 C15orf39 FHL2 NRARP LDB2 VAV2 RND1 SET CAPZB LRRFIP2 ADAMTS9 SRC SHC1 ARHGEF15 SHROOM2 RPL13A HDAC5 SLC25A11 PPM1G HDAC9 DNAJB4 HDAC7 FAM120A DNAJB9 FYN WASF1 NFATC2 CCL2 SLC25A25 PTPN1 PDE4DIP PTPN11 NFKBIA CDC42BPB FMNL3 PTPN9 PTPN6 CTNNA1 ITGB3 RPS6KA5 GRB10 BMP10 ELOA HEL-S-133P RAB4A PLAUR MAPK9 MAPK8 STAT3 ARF6 CTGF TXN MYO1C HEL-S-99n TUBB8 TUBA1C TRPC3 NRP2 PSMD4 FBXW11 F3 SELE LMAN1 MAPKAPK5 PSMD11 DECR1 SIAH2 EGR1 HEL107 ATP6V1E1 CYP2C8 BIRC5 KL MYH9 ERG TRAF3IP2 FLT1 FOXO1 HEL-S-2a PNP MAPK1 MAPK3 ATF2 HEL2 BCL2 SLC8A1 ACTG1 EIF4G1 CACNA2D1 PRKAA1 GJA1 HDAC1 NCF1 PRKCB PRKCE FXR2 PRKCA HEL-S-102 MYL2 PRKD1 BMP2 ATF4 ELOC MOV10 PRKCZ PLCG1 JUN ARF4 NFKB1 TNFRSF25 NAPA TNFRSF10C SH3BGRL3 CLTC HGS SH2D2A AP2A1 NCF2 IQGAP1 ARRB2 FOXO4 AP2S1 SYNJ1 NCK1 EPN1 ADRB2 PLCB3 CREB1 RICTOR CSK S1PR1 ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 AGTR2 REN ACE2 AGTR1 CYP2R1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HEL-S-53e HAT1 HDAC2 HDAC10 DHFR ADH1A HDAC5 HDAC8 ADH1C HDAC9 HDAC7 HDAC6 ATF2 HEL-S-117 ALDH2 SLC19A1 ALDH1A3 MTR HDAC1 ACSS2 TYMS CYP2E1 MAT1A ALDH1A2 HDAC3 KAT2B SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 TRAF3 IF1AA9 TBK1 IFNAR2 TYK2 IFNAR1 IFNA8 MAVS RIGI IFNA2 ACE2 IKBKE IRF9 IFNA6 IFNA7 TICAM1 IFNB1 JAK1 IFNA1 IFIH1 IRF3 TLR3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 NFKB1 MAP1LC3A IFNG IFNB1 MYD88 TNF TRAF6 IRF3 TLR9 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 CD36 LAMB2 CXCL12 FOXC2 FOXC1 TCF2 VEGFA SHH KDR CTNNB1 PAX2 WT1 SIX1 CD2AP FGF8 NPHS1 NPHS2 NOTCH2 HEL-S-28 LMX1B LHX1 ROBO2 CXCR4 FGFR2 HOXD11 HOXA11 SLIT2 TCF21 GLI3 KIRREL1 ETV4 MAFB NCK2 EMX2 NCK1 FOXD1 EYA1 WNT4 GDNF RET INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 IF1AA9 IFNAR2 IFNW1 IFNGR1 PIK3CA IF1IB1 TYK2 IFNAR1 IFNA8 IFNK IFNA2 IFNL2 IFNL3 PIK3R1 IRF9 IFNA6 IFNL4 IL10RB IFNGR2 IFNLR1 IFNA7 IFNE PRKCA IFNB1 IFNG JAK1 IFNA1 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling GSK3B CREBBP NR2F6 STAT1 STAT3 CRP VAV1 SHC1 TYK2 SOCS3 IL6 NLK MAPK1 MAP2K4 MAPK3 BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2L1 PRDM1 HDAC1 RPS6KB1 MAP3K7 JUNB IRF1 IL6R VIP RAC1 JAK1 GRB2 NCOA1 TIMP1 SOS1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG INS PCSK2 PCSK1 GLP1R NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NKX2-1 FOXG1 TGIF1 NODAL TGIF2 GLI3 FGF8 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PLCB4 ITGB1 EGFR PAK1 FLT1 INSR CDH6 FGFR4 CDH2 NRAS DDB1 FOXM1 CDH16 IGF1R KDR PDGFRA CTNNB1 MYC KRAS MET FLT3 CTNNA1 FGFR2 ITGB3 ITGA2B PRKACG EPHA2 NTRK1 ITGA1 CDH9 KIT PAK6 CDH8 PRKAR1B DCAF1 PRKAR1A PAK4 CDH4 ITGA2 CDH10 CDH11 CCND1 CDH12 CDH15 AJUBA ITGA4 CDH17 VGLL4 CD44 ITGB7 CDH19 NF2 CDH24 NGFR WWTR1 PPP1R14A CUL4A LIN28B YAP1 CTGF PPP1CC HEL-S-80p RBX1 CSF1R NTRK2 ITGAM FGFR1 ITGB5 ITGB4 FLT4 ITGAE AMOT ITGB8 ITGAV ITGAX ITGB6 CDH18 LATS1 TEAD4 ITGA7 LATS2 ITGA6 HRAS TEAD2 TEAD3 FGFR3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G6 ACSL3 FADS1 ELOVL5 PLA2G4B FADS2 ACOX1 ACSL1 ACOX3 ELOVL2 FACL4 PLA2G5 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome TUBA2 STAT3 AMER3 STMN2 MZT2A FAM168B CCDC74A CDC27 CCDC42 ARHGEF4 POTEE GPR148 ARHA RAC1 APC PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 ITGB1 MYH9 LAMB2 HEL113 CDH2 MYO1E SCARB2 SMARCAL1 CD151 PTPRO SYNPO CTNNB1 CLDN1 PAX2 FYN WT1 CD2AP INF2 NPHS1 IRF6 NPHS2 HEL-S-28 LMX1B NOTCH1 CDKN1B HEL114 ITGB3 CD80 WNT1 CR1 PLAUR COL4A3 COL4A5 DAG1 LAMA5 TGFB1 PLCG1 CDKN1C COL4A4 TRPC6 MKI67 CTSL KIRREL3 DKK1 VTN KIRREL2 LRP5 TLN1 PARVA LRP6 FAT1 AGRN LIMS1 PLCE1 ACTN4 PCNA ITGB4 YWHAQ ITGAV NCK1 CDKN1A MME EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways LIF PDGFRA PTPN11 EGF FGFR2 SELENOP STAT3 ARAF ACVR1 SMAD1 ACTR2 ERAS ACVR2B PIK3R2 SMAD6 FZD1 WNT10B WNT10A FZD3 MDM2 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 PTEN JAK1 HRAS FGF23 EGFR SMAD4 FGFR4 PDGFA BRAF BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 AKT3 MAP2K3 MAPK1 MAPK12 MAP2K6 MAP2K1 MAP2K2 WNT5B IL6ST HNF1A RAF1 DVL1 DVL2 FGF8A DVL3 WNT1 WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD MAP2K5 AXIN1 JUN WNT16 MAPK7 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC FGF14 FZD4 SMAD9 FGF13 FGF18 FGF12 FGFR1 FGF2 WNT9B FGF7B FGF7A NOG FOS MAPK6 MAPK4 FGF5C GRB2 SOS1 FGFR3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CYP11A1 MAPK10 STAR HEL-S-2a CASP3 BAX HSD3B2 PARP2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A FHL2 GUCY1B1 MAPK1 FHL1 MAP2K1 MAP2K2 ADRB1 MYPN TTN RAF1 CSRP3 NUP62 ANKRD2 HEL-S-101 ANKRD23 C22orf13 MDM2 PRKACG TRIM55 TCAP NBR1 ADRB2 TRIM63 PRKCA PRKAR1A ANKRD1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 SOX17 FOXC2 FOXC1 TCF2 BMP4 GATA3 CTNNB1 SPRY1 PAX2 WT1 SOX11 LHX1 ROBO2 HOXD11 HOXA11 HOXC11 SLIT2 IFT27 GLI3 SALL1 IFT25 ROBO1 SIX2 GREM1 ALDH1A2 EYA1 GDNF FAT4 RET BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs ACACA PCCA PCCB ACACB PC MCCC1 BTD HLCS MCCC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety GCG LEP POMC GHRL MC4R AgRP NPY PYY ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis TLR4 MMP9 STAT1 SGCA SRC SOCS1 DMD MAPK1 TNF FYN MAPK3 HEL-S-28 BCL2L1 BCL2 EIF4G1 CXCR4 CD80 CASP6 RAC3 IL12B IL12A TICAM1 NFKB2 CD40LG IFNG PABPC1 CCND1 CYCS GSK3B DAG1 CASP9 NOD2 CASP3 TGFB1 HLA-DMA STAT3 BAX IL10 CASP2 DFFB DFFA IL2 IL6 TLR5 CCR5 CASP8 CD55 CCR3 PIK3R1 PARP1 AAG1 PS1TP5BP1 PYCARD CAAP1 SGCD EDN1 CXADR SGCB MYH6 SGCG AIF1 CHRAC1 CREB1 BNIP2 ABL2 MICA JAK1 SOS1 TLR3 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NLRP3 IKBKE CHUK RELA FCGR2A TBK1 IKBKG NFKB1 IFNB1 IKBKB IL1B REL GSDMD CGAS NLRX1 MITA F3 NFKBIA IRF3 NFKBIE LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G1B PLA2G4E SLCO2A1 PLA2G4C PLA2G3 PLA2G7 PLA2G10 PTGS2 ALOX5 PLA2G5 PLA2G6 CDKN1A HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYLK EGFR PAK1 ACTR3 DAAM1 MYL1 PFN4 PFN3 PFN2 CAMK1 SRC SHC1 CTNNB1 NEF3 MYC ERBB2 MAP2K4 MAPK1 NEFH ERBB4 NEFL GPX1 HEL-S-44 MAP2K1 TGFA RAF1 CDKN1B DVL1 PPP2CA PFN1 GSK3B MAPK8 AXIN1 FZD10 PLCG1 ROCK2 WNT16 JUN TMSB4X ARHA ACTR2 APC FZD4 FZD1 FZD3 CBL FZD2 FZD5 FZD7 FZD9 NCK1 FZD8 CDKN1A ACTA1 GRB2 SOS1 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 CALM1 STX1A PPP1R10 KCNQ3 PLCG2 AKAP5 P2RY1 CSNK2A1 SCN1B CHRM1 PRKCA BDKRB2 PPP3CC AGTR1 BACE1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A ADCY3 ADCY1 ADCY8 CNTF CAMK2G IL10RA BDNF LIF LTA SOCS3 GFAP GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 IL10RB IFNGR2 IL12B IL12A IL6R IFNG SLC1A4 CAMKK1 CAMKK2 TRAF5 TGFB1 STAT3 IL10 IFNGR1 IL13 PPP1CC ARC IL4 HEL-S-80p SLC2A3 SLC1A1 GRIN2B SLC6A9 GLS2 DLAT JAK1 TGFBR2 IL1A PLCB4 SMAD2 PLCB1 SMAD4 PLCB2 INSR STAT1 IGF1 PSAT1 TGFBR1 PSPH NELF GRIN1 SLC38A3 SLC38A5 DAO GRIK5 SLC1A2 GRIK3 IRS1 GRIK1 SLC7A10 MAPK1 TNF GRM2 GRM4 MAPK3 GRM8 PHGDH SRR LRRC8C IL6ST LRRC8D DISC1 LRRC8E BCL2 HEL-S-51e PRKCB PRKCA NFKB2 IL1R1 SLC38A1 GLS HEL-S-15 PIG59 GRIK2 TGFBR3 TNFRSF1A NFKB1 IL6 DLD CALM1 PDHA1 SLC1A3 SHMT1 FGF2 SLC17A6 SLC17A7 FOS IL13RA1 NGF PLCB3 TNFRSF1B CREB1 IL1B IL1R2 CAMK2D CAMK4 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 ADAMTSL2 EGF ZEB2 LTBP1 ZNF423 pp6425 BAMBI FBN1 LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency CCND2 CREBBP PPP2R3A EP300 PPP2R2C FOXD3 PPP2R2B POU5F1 WNT7B WNT7A CTNNB1 MYC CTBP2 MAP2K4 SOX2 WNT5B ZBTB33 LDLR PPP2R1B PPP2R1A LRRK2 PPP2R2A LEF1 CCND3 FBXW2 PAFAH1B1 PPM1J PRKCH NKD1 NKD2 PRKCB NFYA MAP3K7 ESRRB NR1C2 PRKCE PPP2R3B DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PPP2CA PRKD1 CCND1 GSK3B WNT2B CD44 MAPK10 PRKCZ MAPK9 AXIN1 FZD10 FRAT1 AXIN2 WNT16 JUN CSNK1E LRP5 NLK LRP6 ARHA APC CTBP1 FZD4 FOSL1 FZD1 WNT10B CTNND1 WNT10A FZD3 FZD2 PPP2R5E WNT9B FZD5 FZD7 FZD9 FZD8 PPP2R5C MMP7 PTPA SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway EMC7 MICOS13 OPA1 MFN2 APOOL MMGT1 IMMT EMC10 TMEM85 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 MFN1 EMC6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways SLC25A15 MDH2 ASL GOT2 NAGS SLC25A12 ASS1 GLUD1 ARG1 SLC25A13 LDHB FH OTC GLS2 GPT NOS2 HEL-S-32 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 ARHGEF1 ARHA 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation STX1A CREBBP NECAB3 APP SPEF1 SMC5 RELA SMC6 LYPD6 ENTREP2 UBN1 MLSN2 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J CXNO CGN CCL5 GOLGA8R GJD3 MTMR10 CANX KLF13 MYZAP OTUD7A TJP3 GOLGA8O CDC42BPB GOLGA8Q TRPM1 FANCD2 STXBP1 GOLGA8H CALM1 FAN1 CHRNA7 ANKRD2 GJA1 HDAC1 CXADR TJP1 SIN3A KAT2B STX1B IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta TF HAMP IREB2 TFRC HEPHL1 TFR2 SLC40A1 MCOLN1 SLC11A2 HEL60 STEAP3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 NR1C2 FFAR3 PYY FFAR2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 SGPL1 PEMT CHPT1 CEPT1 PISD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL OTC NAGS F7 GLS2 ASS1 GPT ARG1 F10 HEL-S-20 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling PIK3CD IL2RG RELA EP300 CHUK STAT1 STAT3 GAB2 CEBPA CEBPB PIK3CA SHC1 TYK2 NFKB1 IL4 SOCS3 SOCS1 IRS1 MAPK1 FLNA MAPK3 INPP5D BAD ATF2 PTPN11 MAPK11 MAPK14 NFKBIA PIK3R2 PTPN6 PIK3R1 FES SOCS5 CBL RPS6KB1 FOS IKBKB JAK1 STAT5B JAK3 GRB2 SOS1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CAP1 ELOVL5 IGF2R LPL CYP1B1 CEBPB PICALM SRSF9 TMED10 TMEM43 PHC2 TGFBR2 SRSF10 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling GSK3B ITGB1 SMAD2 WASL MAPKAP1 IGF1 IGF1R TNFRSF1A NFKB1 IRS1 RPTOR MTOR DEPTOR ACVR2B MLST8 HEL-S-28 EIF4E TNLG5A RPS6KB1 IGFBP5 PRKAB1 AKT1S1 MAP1LC3A TRIM63 PTEN EIF2B2 FBXO32 PPARGC1A RICTOR GDF8 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR STAT3 ROCK1 PLCG1 BDNF PIK3CA SHC1 NTRK2 GABRG2 ARHA PIK3R2 PIK3R1 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 CREM GABRE GABRQ GABRA2 GABRP SLC12A5 PIK3R3 GABRA6 PTEN GABRA5 GABRA4 GABRA3 CREB1 GABRG3 GABRG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PLCB4 POMC PLCB1 PLCB2 ARRB2 GPR143 PRKACG VEGFA PRKCB DCT GNA15 PLCB3 CREB1 ADCY9 PMEL ASIP GNAS TYRP1 TYR MC1R FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 APOB NR1C1 ACADM HADHB PPARGC1B STK11 ESRRA ACLY MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation GSK3B SPRED1 MAP1B MARK1 TAOK1 PHLDB2 MAPRE1 F2RL2 PAK1 STAT3 RHO ROCK1 SRC PARD6A CLASP1 NTRK2 LIMK1 APC CDC42 EPHB2 DVL1 AURKB NTRK1 PRKCA PTEN NTRK3 RAC1 CFL2 WNT3A CDC2 FREP1 TIAM1 MAPKAPK2 TRIO CAMK4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 RORC EBP AKR1D1 INSIG1 AKR1C4 CYP46A1 THEM5 DHCR7 HSD3B7 GPR183 ACOT8 LBP ACOT7 NR1H2 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 SULT2B1 CH25H AMACR ACOT6 SLC27A2 ACOT4 CYP3A4 DBP CYP7A1 NR3A2 EPHX2 CYP27A1 NR1i2 CYP8B1 SLC27A5 SULT2A1 IL25 ACOT9 IL17F IL17D IL17C IL17B IL17A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR SPHK2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation STX1A TDO2 TSC2 TPH2 ACHE TGFB1I1 TNF HRH3 NECTIN2 MAPK14 ADORA2A SLC5A7 ITGB3 SLC6A3 TNFRSF11B TH RBL2 UNC13B IL1R1 FBXO32 AMPH IL1B SLC6A1 SLC6A2 SYN1 DBH ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR SLIT2 RAC1 ROBO4 VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 ESD PON1 LIPA HEL126 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL1 LOXL2 LOX SMAD2 SMAD4 MAPK9 BMP1 MAPK8 TGFB1 GREM1 TGFBR1 BMPR1A BMPR2 MAPK14 TGFBR2 LOXL4 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GOT2 GAD2 AGXT ASPA ASS1 GAD1 GPT PC ABAT MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 PMVK MVD ACAT2 HMGCR FDPS SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 DLL3 MESP2 LFNG HES7 EPHA4 RIPPLY2 TBX6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 DHCR7 LBR HMGCR NR1H2 CH25H FDFT1 SQLE SOAT1 FADS2 SCD CYP27A1 FADS1 MYLIP ELOVL5 FASN ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK SREBF2 HMGCS1 SOAT2 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 FACL4 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP1 HDAC2 RBX1 STAT1 STAT3 HDAC3 DTX3L BTRC SKP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling SMO SUFU DHH PTCH2 SAP18 KIF7 SIN3A PTCH1 IHH GLI3 ADRBK1 SHH ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 IFNAR1 TNF ACE2 IFNA1 TNFRSF1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS5 PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN2A CCND2 SMAD4 BAK1 INSR NRAS MAP3K1 WNT7B WNT7A SHC1 CTNNB1 HMGB1 MYC AKT3 IRS1 ERBB2 MAPK1 SOS2 KRAS WNT5B BCL2L11 BCL2 LDLR CDKN1B BBC3 LEF1 TNFSF6 CCND3 RAC3 MAP3K7 RBL2 DVL1 PIK3R3 DVL2 TCF7L2 DVL3 TCF7L1 NFKB2 PMAIP1 WNT1 WNT3 MLKL WNT4 G6PC1 PCK2 WNT3A CCNG2 CCND1 GSK3B WNT2B PIK3CD MAPK10 MAPK9 MAPK8 TGFB1 TP73 BCL6 BAX AXIN1 FRAT1 WNT16 JUN PIK3CA NFKB1 ARHA BAD BIK PIK3R4 APC PIK3R2 PIK3R1 CDC42 PIK3R5 FOSL1 PIK3C2G FOXO3A WNT10B PIK3C2A WNT10A MDM2 PIK3C2B ATM PPP2R5E CDKN1A PTEN PPP2R5C RAC1 HRAS GRB2 SOS1 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing TLR4 MMP9 FST KLF4 TNC INHBA FGFR4 VEGFA SNAI2 HMGB1 HGF ACHE TNF CCL2 COL1A2 BCL2 EGF CHRNA7 CXCR4 FGFR2 FBN1 F13A1 PECAM1 FOXE1 HEXD DKFZp686P11128 DCN TIMP1 KRT6A KRT222 FLG IL15 PCTK1 SCEL HEL-S-43 COL1A1 AMBP SLURP1 MYD88 CASP3 LIN28A CD3E CXCL12 TPT1 BAX NFKB1 IL6 CXCL8 S100A6 IFNA2 BRD4 FGFR1 S100A9 NOX4 MMP28 ACTA1 IL8RB IFNB1 MMP2 IL1B CXCL1 FGFR3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p C7orf24 OPLAH GCLC HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 CDK7 RUVBL1 GTF2H2C_2 KARS1 CCNH GTF2H2 JUN GTF2H3 GTF2H5 SH3RF1 FOS NFKB1 HINT1 ERCC2 TCF4 RUVBL2 CTNNB1 MNAT1 NFATC2 USF2 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 AKR1C4 AKR1C2 CYP3A4 CYP1B1 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA ERI1 AGO2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 MAP4K1 MAP4K2 WWTR1 MINK1 YAP1 MAP4K3 RASSF1 LATS1 TEAD4 LATS2 STK38L TNIK TEAD2 TEAD3 HEL-S-31 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 MAPK8 TNFSF11 ITGB3 TRPV5 TNFRSF11B CTSK TNFRSF11A IFNAR1 IFNB1 SPP1 GPR68 AIMP2 ACP5 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB1 CACNB1 CDH2 SGCA CTNNB1 DMD CACNG1 CTNNA1 SLC8A1 CTNNA3 CTNNA2 ACTG1 tmp_locus_29 CACNA2D1 ITGB3 GJA1 LEF1 CACNA1C ITGA2B CACNA1F LMNA EMD TCF7L2 TCF7L1 ITGA1 CACNB3 CACNA1S ITGA2 ITGA4 DAG1 ITGB7 PKP2 JUP ACTN2 ACTN1 ACTN4 CACNA2D3 CACNA2D2 CACNA2D4 RYR2 CACNB4 ATP2A2 DSG2 DSC2 CACNG6 CACNG7 ITGB5 CACNG8 ITGB4 CACNG2 CACNG3 PS1TP5BP1 CACNG4 CACNG5 ITGB8 ITGAV ITGB6 SGCD SGCB SGCG ITGA7 ITGA6 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GSK3B PIK3CD TSC2 TSC1 NRAS UBE3A BDNF GRIN1 PIK3CA ARC NTRK2 DLG4 AKT3 PRKAA2 EIF4EBP1 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 PRKAA1 GRIN3B GRIN3A NF1 CACNA1C PRKAB2 SHANK3 RPS6KB1 RHEB PRKAB1 GRIN2B PIK3R3 SYNGAP1 PTEN HRAS HOMER1 CAMK4 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MEF2C ARAF NRAS BRAF GAB2 CRK MAP3K2 VAV1 SRC PIK3CA SHC1 AKT3 MAPK1 KRAS CRKL MAPK3 SHC4 INPP5D ATF2 SHC2 MAPK11 SHC3 MAPK14 BCR PIK3R1 BCL2 EIF4B HSPB2-C11orf52 BCLAF1 BCL9 RAF1 CBL RPS6KA1 SPAG1 PXN DOK1 HEL-S-102 HRAS GRB2 SOS1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 ANGPT2 PRKD3 PPP3R2 PRKCZ RCAN1 PRKCH PKN3 PKN2 PRKCB PKN1 NFATC1 PRKCE PRKCA PLCB3 PPP3CA PPP3CC PRKD2 PRKCI PRKCQ PRKD1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling IFITM3 CEBPB CCL8 RPTOR CCL4 LARP1 CCL1 DEPTOR MLST8 VPS11 EIF4E VPS16 CCL15 VPS18 GABARAPL2 VPS33A RPS6 RHEB AKT1S1 VPS41 HIF1A AHR LCK IF2B1 TF CD3G IL-21 CD3E CXCL12 IL18RAP PIAS1 IL10 IL13 IL4 IL5 RRAS CXCL8 APOC1 SMAD1 ULK1 SIGMAR1 IL9 HEL117 MMP25 IFIT1 GTSE1 VPS36 WDR74 CD226 TRPM2 APOH APOD RAC1 HEL103 JAK1 INTS4 HRG CXCL13 CTSZ TGFBR2 SERPINA10 SDF2 CCR6 IL1A TOMM70 GP1BA IL16 HMFT1766 IFI6 OS9 PTGS2 MIB1 STAT1 SRP19 HEL-S-81p HP IFI44L CLCC1 TLE3 GTF2F2 UGCGL2 G3BP2 CXCL6 NLRP1 DKFZp781O1323 NPTX1 MDN1 IFITM1 FAM83A CXCL3 NEK9 IL7 CD163 TP53I3 LGALS3BP TNF TRO TRIM59 BST2 ITIH3 ATE1 IFI27 MX1 CCL20 TBKBP1 ATP13A3 IL33 FAM98A CCL22 CCL21 HBB CCL27 PF4 CCL26 DDIT4 RTN4 FGA HEL-S-78p NFKB2 ALB SAA1 SAA2 IRAK1 CASP9 MYD88 CASP3 TRAF2 TRAF6 SRP54 HBD CXCL5 MTOR TPO FGF2 PMPCB IFNB1 ADAM9 IL1R2 CXCL9 PITRM1 CXCL1 CCL3 NLRP3 HEL-S-130P CXCL2 CRP RRM2 GGH CCL11 ZAP70 CARD11 CCL5 EIF4EBP1 HLA-DRA NFATC3 FYN CCL2 APOA2 PTPN6 OAS2 IRF9 C8A IL12A C1QBP CCNB2 IFNG CCNB1 CDC2 IL17A HLA-DRB5 NRF CD8B1 MAPK8 PRG3 CD2 CFH IGLL1 CD8A CFI LBP CFP CTSL CPN1 CASP8 PARP2 C1R SELP HEL-S-72p EGR1 IFIH1 IRF3 CD14 BIRC5 ITIH4 TRAF3 HLA-DRB1 APOL1 ACE2 CASP5 COQ8B ACTG1 TNFSF10 STEAP3 JUNB NTRK1 PRKCQ MOV10 DKFZp762B153 TBK1 IKBKG JUN IL6 CCR5 MAVS RIGI EIF4A2 PS1TP5BP1 CXCL16 FOS IL8RB IL18 IL1B CXCR1 ITCH CAMK4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling GSK3B RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 CEBPD CTNNB1 SPP1 APC CSNK1A1L TOR1AIP1 SLC2A4 CDK6 PPARG WNT10B LEF1 ZMPSTE24 FNTA LMNA HES1 EMD HES5 TCF7L2 TCF7L1 ICMT HMGA2 DICER1 TARBP2 CCND1 AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 SMARCC1 SMARCA4 MBD5 NCOA6 SMARCD2 ARID1A PAXIP1 SMARCC2 SMARCD3 KMT2C ACTL6B DPY30 ARID1B PAGR1 ASXL1 WDR5 BAP1 ACTL6A EHMT1 ASH2L H3F3B RXRA NR1I3 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways OSTM1 PLEKHM1 NFKB1 SNX10 TNFSF11 IKBKB TCIRG1 TRAF6 RAB7A TNFRSF11A CLCN7 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 CYP24A1 AGTR2 REN KLKB1 ROCK1 NFKB1 CPN1 KLNA1 BDKRB2 CYP3A4 PRKG1 IL1B MAPK1 NR1i1 TNF ARHA BDKRB1 ACE2 AGTR1 IL1A SERPING1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome USP9X PDE6D BBIP1 DYNC2I2 INVS NPHP3 DYNC2H1 CRX DYNLT2B TRAF3IP1 SUFU CEP164 FLCN DYNC2LI1 IFT52 KIF7 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 OCRL CEP290 SCAPER ZIC2 BBS4 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK IFT172 TMEM216 EFHC1 WDPCP EFHC2 IFT74 CNGB1 SDCCAG8 PKD1 CEP104 ARL6 ARL3 PKD1L1 PKHD1 PTCH1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 PCARE SMO SCLT1 DCDC2 IFT81 FUZ TTC8 GPR161 MKS1 CEP41 IFT27 TRIM32 GLI3 CLUAP1 RAB23 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1A2 NAA50 CYP2J2 GATF-C CYP21A2 GLYATL2 AKR1D1 CYP4F11 AKR1C4 CYP46A1 CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 LOC51064 CYP7B1 SULT2B1 HS2ST1 SULT1C3 CYP26B1 CYP4V2 HYAL3 CYP2C19 UGT2A2 CYP3A7 UGT2A1 CYP3A4 GAL3ST2 CYP2W1 GAL3ST3 SULT1C4 CHST8 HS3ST3B1 CHST9 EPHX2 CHST6 CHST7 CYP2R1 CYP3A43 KCNAB1 KCNAB3 CYP2A7 CYP26C1 CHST1 CHST4 CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 CYP17A1 CYP2A13 UGT1A5 AKR1B1 CYP2F1 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 GSTZ1 CYP20A1 CYP4F2 CYP4F12 HEL-S-165mP EPHX1 CYP7A1 CYP11A1 MGST1 GSTT2 UGT1A3 SULT2A1 CYP1A2 CYP1B1 MGST3 GPX3 MGST2 CYP1A1 CYP2E1 GSTM3 NNMT TPMT INMT GSTM5 CYP4F8 CYP2C8 UGT2B4 UGT2B7 NAT2 CYP2S1 GSTM1 SULT1A1 SULT1E1 BAAT CYP27B1 SULT1C2 CYP11B2 HEL-75 CYP27A1 GSTM2 CYP8B1 GSTA5 CYP2C9 GSTA4 CYP2A6 GSTA3 UGT1A10 CYP2B6 UGT1A1 UGT1A9 HEL-S-64p HS3ST2 GSTM4 GPX4 CYP51A1 CYP24A1 GPX2 HEL-S-22 UGT1A4 UGT1A7 AKR1C1 AKR1C2 HEL-S-75 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 HEL-S-21 HEL-S-166mP UGT2B11 GAL3ST4 UGT2B15 UGT2B17 CYP2U1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP2C18 CHST13 CHST14 NAT8L GSTT2B SULT1A4 CYP4F3 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CDKN2A EGFR MAPK8 BAK1 BAX TRAF2 TRAF6 JUN TNFRSF1A FAS PDGFRA IL2 IL6 MAP2K3 HBEGF MAP2K4 TNF MAPK12 BMF MAP2K6 MAPK13 MAP3K5 ATF2 FGF7 MAPK11 MAPK14 BCL2L11 BCL2L1 BCL2 NFE2L2 TNFSF10 TNFSF6 CCNE1 JUNB FOS CCNA2 CDKN1A IFNG RB1 MMP2 MCL1 CCND1 TRAF5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 ATG3 TSC2 INSR TSC1 ATG12 ATG16L1 INS ATG14 MAP1LC3A ATG5 AMBRA1 SH3GLB1 CHAF1A UVRAG ATG9B ATG10 ULK2 VMP1 ULK1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 GCK ACSS1 MTTP LMF1 LDLR PLTP GPIHBP1 LPL FAS PDIA2 APOA5 APOC2 LIPC GCKR DGAT2 APOA2 SEL1L COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SGOL1 PTTG1 ESCO1 ESCO2 REC8 SMC1B MAU2 STAG2 SMC3 STAG3 ESPL1 WAPAL HDAC8 APC PLK1 PDS5B PDS5A PPP2R1B RAD21 PPP2R1A PPP2R5E SMC1A PPP2R5B PPP2R5A AURKB PPP2R5D PPP2R5C PTPA PPP2CA CDC2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation PDLIM7 SLC34A1 FGFR4 PFN3 IGF1R CAPN3 SRC GRIN1 MYC KDM6B HEL-S-273 COX2 GPRIN1 ARL10 H2AX CXCR4 ADAM10 PTH FGF8A TMED10 HK3 NTN1 COX1 MAPK10 MAPK9 MAPK8 GNAI1 RNP24 PLCG1 PRR7 EIF4E1B GNAI3 JUN COX7B KIAA1191 COX4I1 FAF2 MAX CLTB DDX41 TRIAP1 COX6A1 BABAM1 BABAM2 BARD1 UIMC1 COX8A EED INPP5D TMED9 RNF44 CYP7A1 UNC5A MYO7B PNPLA2 COX6B1 PIK3R1 ARFGAP2 FBXW7 HIC2 DOK3 CDHR2 FAM193B DBN1 ABRAXAS1 USH1C BRCC3 COX7A1 LMAN2 MAGED1 RAB24 COX7C COX3 ZNF346 SNCB PRELID1 PTPRN2 NELFB NOP16 GRIN2B MUPCDH COX5A HIGD2A TSPAN17 BRCA1 DRD2 SNCA ANKS4B H3F3B MXD3 FRS2 ABHD5 GRB2 SOS1 RGS14 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis DHRS7B AGMO AGPS LPIN1 LPIN2 LPIN3 CEPT1 FAR1 UGT8 PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L PEX3 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation MIXL1 ITGB1 KLF4 CNP HOMER3 MBP FOXD3 MSX2 PAX3 MOG S100B OLIG2 SOX10 GFAP ACHE TWIST1 GATA4 NEFL MSX1 LHX1 GAD2 NR2A1 TPM1 GAD1 GATA6 MAP2 TWIST2 DLG4 CLDN11 ERAS CASK CACNG2 ROBO1 SHANK3 GRIN2B SLC6A5 SLC6A9 DLG2 SHANK1 SLC6A1 SLC6A2 HOMER1 TNC AQP4 RIMS2 BSN CDH2 RBFOX3 FBXO15 TBR1 SNAI1 ZFP42 SNAI2 LIN7A BMP4 FUT4 POU5F1 TPH1 ChAT HOMER2 GRIN1 FEV CD24 NEF3 PCLO ERC1 SLC1A2 CD34 PAX6 ADRA2C ADRA2B ADRA2A DPPA3 DPPA2 SOX2 DCX TBXT GLRA1 GLRA2 LMX1B GLRA3 NOTCH1 GABBR1 HTR5A GLRB RIMBP2 NLGN1 5HT1A CSPG4 FOXA2 SLC6A3 LEF1 HES1 ESRRB HES5 PECAM1 GLS NGFR SOX17 PIG59 GPHN GABBR2 KCNJ6 SNAP25 SOX9 SLC1A3 NODAL AP2A1 AP2A2 TH SLC17A6 SLC17A7 FGF7A SLC18A3 HES3 UNC13A ITGA6 SYP CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 ADCY1 MAPK9 MAPK8 DAGLA CYP2C19 CYP3A4 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 ADORA2A FAAH CYP2C9 CNR2 NAPEPLD DAGLB PRKACG CYP1A1 PRKAR1B CNR1 PRKAR1A AHR TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R5 PIK3CD EGFR RAF1 PIK3C2G PIK3C2A PIK3C2B NRAS PIK3CA PIK3R3 AKT3 ERBB2 MAPK1 ERBB4 KRAS MAPK3 HRAS PIK3R4 PIK3R2 PIK3R1 ERBB3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IF2B1 IL15 RORC RORA ID2 TBX21 IL13 GATA3 TOX IL4 IL6 IL5 IL7 TNF IL33 ZBTB16 HNF1A TSLP IL9 IL25 GFI1 ATL1 NFIL3 IL12B IL12A IL18 IFNG IL23A IL1B AHR IL17A AREG MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TAOK1 CACNB1 LAMTOR3 RRAS2 CACNG1 SOS2 EGF FGFR2 PRKACG PLA2G4B ARAF CDC25B NFATC1 MAX RASGRP3 RAP1A RRAS DDIT3 CRKL GADD45A CACNA2D3 CACNA2D2 PPP3R1 CACNA2D4 PPP3R2 CACNB4 CACNG6 CACNG7 CACNG8 NF1 CACNG2 CACNG3 CACNG4 CACNG5 MAP3K13 IKBKB PPP3CA RAC1 PPP3CC HRAS TGFBR2 IL1A EGFR NTF4 PAK1 RELA FGFR4 NRAS MAP3K1 MAP3K7IP1 FAS FGF10 RPS6KA3 MAP2K3 MAP2K4 TNF MAPK12 MAP2K6 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K11 SMIM40 RAF1 TNFSF6 CACNA1C CACNA1F FGF8A NFKB2 IL1R1 CACNA1S FGF6B MAPKAPK2 MAP2K5 CASP3 CHUK TRAF2 TRAF6 CRK TNFRSF1A MAPK7 NTRK2 NLK FGF20 FGF22 FGF7 FGF21 FGF8 DUSP4 FGF9 FGF16 FGF14 FLNB CDC42 FGF13 TAOK2 FGF18 FGF12 FGFR1 FGF2 FGF7B FGF7A DUSP2 NGF FGF5C IL1R2 GRB2 SOS1 FGFR3 MEF2C BDNF FLNA NFATC3 STK4 RPS6KA4 RPS6KA5 RAC3 MAP3K8 MAP3K6 MAP3K7 MAP3K12 HEL-S-31 MAPK10 MAP4K1 MAPK9 MAP4K2 MAPK8 TGFB1 MAP4K3 MAP3K2 HEL-S-103 HEL-S-72p RASGRF1 MAPKAPK5 HSPA2 PLA2G4F CD14 FGF23 PLA2G4D PLA2G4E PLA2G4C PDGFA BRAF TGFBR1 MYC AKT3 JUND MAPK1 DUSP10 KRAS MAPK3 ATF2 CACNA2D1 LRRK2 MAPK8IP3 MAPK8IP1 ECSIT DUSP3 DUSP8 DUSP9 DUSP7 PRKCA RAPGEF2 NTRK1 NTF3 TAOK3 CACNB3 RASGRP4 CACNA1H CACNA1G CACNA1I HEL-S-102 RASGRF2 DUSP16 PPM1B RASA2 pk ATF4 PPP5C MAPK8IP2 RELB IKBKG JUN GNG12 MAPKAPK3 NFKB1 MAP3K14 CACNA1B CACNA1A ARRB2 FOS IL1B PTPN5 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABBR2 GABRG2 SLC6A11 GABBR1 GAD2 AP2A1 GAD1 AP2A2 GABRB3 GABRB2 ABAT AP2S1 GABRB1 GABRE GABRQ GABRA2 GABRP AP2M1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 SLC6A1 GABRG1 SLC32A1 ALDH9A1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HEL25 CBX3 MBD2 CBX1 CHD4 HDAC2 CHD3 MTA2 H3C8 RBBP7 MTA3 MBD3 HDAC1 LEF1 SUV39H1 KDM1A H3C15 RB1 H3F3B RBBP4 KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome TMEM98 GNRH1 NEUROG1 FGFR1 SEMA3E ASCL1 OTX2 ANOS1 PIK3CA PLXND1 OLIG2 PROK2 SOX10 MYRF FRS2 MAPK1 LHB PTPN11 FGF8 GRB2 MAP2K2 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma DKFZp762B153 NFE2L2 STAT3 TFEB MDM2 IPO8 PINK1 AGER PARK2 NFKB1 HMGB1 SQSTM1 KRAS VMP1 SHOC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP2C8 FADS1 ELOVL5 ALOX12 LTC4S PTGS2 CYP2C9 HEL-S-22 ALOX5 ALOX15B CYP1A2 ALOX15 HPGD GPR32 FPR2 CYP2E1 PTGS1 PTGIS CYP3A4 GSTM4 FADS2 EPHX2 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 RPS6KA5 BRAF HTR4 HTR6 HTR7 RAP1A CREB1 MAPK1 EGR1 MAPK3 ATF1 GNAS MAP2K1 MAP2K2 MAPKAPK2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome AFDN F11R GJA3 GJA5 ACP6 CTNNB1 GJA8 AMELX NBPF12 CHD1L PRKAA2 PYGO2 TJP3 PRKAG1 PRKAG2 PYGO1 BCL9 PRKAG3 PRKAA1 GJA1 KIRREL1 PRKAB2 PRKAB1 FMO5 TJP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex HIST1H2BE HAT1 ASF1A CREBBP ASF1B HDAC2 EP300 MBD3 EP400 MAPK3 H2BC21 H2AX HDAC1 TLK2 RBBP4 KAT2B MBD2 CHD4 CHD3 MTA2 H3C8 H3C15 PWWP2B UBTF PWWP2A TBP SIRT7 POLR1A POLR1C POLR1D RRN3 SRCAP TAF1D H2AC19 TAF1B H2AB1 TAF12 H2AC14 GATAD2B H2BC26 GATAD2A H2BC12L CDK2AP1 HIST1H2AB H2BC9 KAT2A H2AZ1 H2AZ2 H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 H2BC1 H2BC17 H3F3B H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2AC20 H2BC11 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PLA2G1B PTDSS2 PTDSS1 CHKB PCYT2 ETNK1 GPAM PEMT CDS1 CHPT1 CRLS1 PISD AGPAT4 GPAT4 PNPLA3 DGKZ DGAT1 DGAT2 CDIPT PNPLA2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP EPHX1 CYP3A4 CYP1A2 GSTM1 CYP2A13 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle MCM5 MCM6 TTK CDKN2A CCND2 FZR1 HDAC2 CDC45 WEE2 EP300 CDKN1B CCND3 E2F2 ANAPC1 SMC1A CCNA2 CCNE2 CCNB3 CCNB2 RB1 CCNB1 GADD45B CDC2 GADD45G CCND1 CHEK2 CHEK1 PTTG1 TGFB1 SMC1B CDC25B STAG2 CCNH SMC3 CDC27 ESPL1 E2F4 GADD45A PLK1 TFDP2 MCM2 RAD21 CDK7 MAD2L2 STAG1 MDM2 CCNE1 ATM ATR CDC20 SMAD2 SMAD4 WEE1 CDK4 MYC CDK2 HEL2 HDAC1 RBL2 RBL1 TFDP1 CDKN2D CDKN2B E2F5 CDKN2C GSK3B SFN CDKN1C SKP1 RBX1 PRKDC PCNA CDK6 E2F3 YWHAQ HEL-S-1 CDC14B YWHAG CDC23 PTTG2 SKP2 ANAPC7 ANAPC5 YWHAZ MAD1L1 ANAPC2 CDKN1A ANAPC13 PKMYT1 ANAPC11 ORC6 ORC3 ORC2 CDC6 MCM7 ORC1L DBF4 MCM3 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23 HEL-S-310 RPS6KA2 RPL4 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPS15 FAU RPS14 RPL13A RPL7A RPS6KA3 RPS17 RPS16 RPS18 RPL36 RPL35 RPL38 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPS6KB2 RPL5 RPL22 RPS3A RPL30 RPL7 RPSA RPS6KA6 RPL18A RPS6 RPL37A RPL29 RPL28 RPL10 RPL12 RPS11 MRPL19 RPS6KB1 RPL36A RPS4Y1 RPS15A RPL14 RPS19 RPS3 RPS27A RPL13 RPS2 RPL11 RPL15 RPL18 RPL17 RPL19 RPL27 RPL41 RPL35A RPL26 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP2 RPL10A RPS6KA1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation HDAC10 FHL2 LDB2 PAX3 SOCS2 DMD HDAC6 FYN CCL2 CDON PRKAG2 ZBTB16 LHX1 CTNNA2 FGFR2 MAFB POU2F2 ELOVL4 GATA6 NR1C2 TCF3 NUMA1 CDH8 SDCBP GAS2L1 KRT6A RGMA NF2 CTNND2 ARHGDIG KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E ARX STC1 NFATC1 ARHGAP15 ZBTB2 JUP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B TFAP2C SMURF1 GREB1 NR2F2 CLDN11 PAN2 PTPRB PPFIBP2 SCHIP1 HMGB2 WDR44 SIX6 AHI-1 BOC RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 FZD5 ARHGEF9 BMPR1A KIFC3 RUTBC3 STX16 FZD8 RRBP1 TBL1X CLVS1 TTC14 TNLG7C SNCA C1GALT1 TRPM2 VAX2 RIT1 GLB1 ZNF219 BCOR SKIL MYORG ELOVL2 SMAD4 CDH6 OGT BMP4 SHH CTNNB1 MYC PAX6 TFAP2A SOX2 CAP2 PDE7A NLGN1 FOXA2 TNFRSF11B TCF7L1 WNT1 SPRY2 CELSR2 NLK UBTF ZFHX4 PTPN13 PIM1 CTBP1 FZD4 MKS1 GLI3 H2BC9 TOX3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway GALNT9 MAMDC2 ATP1B2 MID1 ERAF CRTC2 SPINT1 PAK1 C1QTNF12 EPOR EP300 FAM20C RELA SPIRE1 ARHGEF7 SFI1 IFI44L ATP10D TSPAN33 RHD CAMK1 ENHO CYB5R3 TSPAN8 SLC25A21 NLRP1 KDR FIS1 STIM1 SLC38A5 WFS1 KLF1 LR8 SLCO3A1 CCL5 TRPV4 CPOX MAPK1 RHAG TNF MAPK3 NFATC2 HFE RPTOR TBXT SLC2A4 ACACA RAF1 FASN NFE2L2 RPS6 SIRT1 ABCA1 RPS6KB1 SMC1A MAP1LC3A SQSTM1 HIF1A CAMKK2 PCK2 CCND1 MX2 KEAP1 VCAM1 GCK IL15 HMBS DKFZp762B153 CHRM3 TSC1 WDR35 DGIC HMOX1 PFKFB2 HK2 ULK1 MTOR CALM1 SELL PARP1 ASNS CCNE1 S100A8 AQP1 CREB1 RAC1 MAF MS4A3 CXCL11 IFGGE OASL ERMAP CAMK4 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CHRNB4 CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA EGFR PTEN RPL11 AKT3 FOXO3A MAPKAP1 RICTOR RIOK2 RIOK1 MTOR MLST8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 MAVS RIGI IFIH1 MR1 IRF3 TLR8 TLR7 TNFRSF11A TLR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion GNA11 PLCH1 PLCD3 PLCB1 PLCB2 PLCB3 PKD1 PLCG2 PLCG1 PLCL1 PLCE1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 ARID5B TBX1 UCP1 PRDM16 PPARGC1A IRX5 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC RBX1 CBFB CUL5 UBB RUNX1 APOBEC3G NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B3GNT5 NEU2 FUT5 B4GALT1 FUCA1 FUT1 NAGA FUT2 SIAT4C B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NFE2L2 TGFB1 NQO1 SIRT1 CDC37 EXOC6 ECSIT DDR1 SUV39H1 NRF1 HEL-S-7 PKD1 COL2A1 FGF7 BMP2 IGFBP7 LOXL4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC1A RAD21 RAD18 PAXIP1 BRCA1 MRE11A MDC1 ATM SMC3 NBN RAD50 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELE TLR4 SELP TGFB1 SELPLG PF4 CD40 CD40LG CCL5 IL1B CCL2 TLR7 VCAM1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism CD36 STAR PBR LIPC LIPA APOA2 CYP27A1 PCSK9 APOA4 SCARB1 MTTP APOB LDLR MYLIP PLTP ACAT2 LPL HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK LIPG MVD NPC1 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 CIDEB FABP2 VAPA EBP CYP51A1 SC5D DHCR24 DHCR7 LBR LPA HMGCR FDFT1 DGAT1 SORT1 SQLE APOC2 SOAT1 APOC3 ABCG8 APOC1 ABCG5 CYP7A1 APOE ABCB11 APOH STARD3 NPC1L1 NPC2 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DROSHA MRE11A ATM NBN RAD50 DDX1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 NFE2L2 SLC3A2 SLC7A5 KEAP1 ATF4 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling HHIP SPOP CSNK1G3 CCND2 SMURF2 FBXL17 SPOPL CSNK1D GAS1 CSNK1G2 CSNK1G1 EVC ADRBK1 CSNK1A1 SHH CSNK1E DHH IHH SMURF1 PTCH1 CDON EVC2 CSNK1A1L BCL2 SMO BOC ARRB2 GPR161 GLI3 PRKACG SUFU PTCH2 KIF3A KIF7 CCND1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL5 ACE2 FADS2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PHGDH PSAT1 PSPH ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling RELA STAT1 CEBPB VEGFA SRC TYK2 SHC1 SOCS3 IRS1 CDK2 MAPK1 JUND KRAS MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 IL6ST RAF1 CDKN1B RPS6 PRKCH PRKCB PXN JUNB PRKCE PRKCA OSMR HIF1A STAT5B PTK2B JAK3 OSM MAPK9 MAPK8 CASP3 STAT3 NFKB1 MTOR PIK3R1 FOS CREB1 JAK1 RICTOR EGR1 HRAS GRB2 SOS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 MAPK1 RYR3 ITGB3 MFAP5 MAPK3 TNNC1 PRKCQ PLCG1 JUN ITGAV GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis NOTCH1 MESP2 LFNG HES7 EPHA4 RIPPLY2 WNT3A FGF8 TBX6 HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC1H1 DCTN1 ADCY3 RAB11B DYNC1LI2 DNCL1 ADCY6 AQP4 ARHGDIG DCTN6 DCTN5 DYNC1I1 RAB5B DCTN4 HEL-S-47e HEL-S-77 AQP2 AQP3 ARHGDIB AVPR2 DYNC1LI1 RAB11A GNAS RAB5A DYNC2H1 CREB3L3 AVP CREB3L4 PRKACG DYNLL2 CREB3L2 CREB3 RAB5C DYNC2LI1 CREB1 ADCY9 STX4A CREB5 VAMP2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling BCL2 MAPK9 CHUK GNGT1 BRAF IKBKG JUN PIK3CA FOS NFKB1 SP1 GPER IKBKB CREB1 MAPK1 GNB1 GNAS MAP2K1 MAPK14 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle INS SLC2A4 HEL-S-68p PGAM1 HEL-S-133P PFKP GPT HEL-S-49 HEL-S-87p HEL-S-162eP SLC2A2 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK1 TLR4 IRAK4 MYD88 TRAF6 AGER NFKB1 TREM1 IL6 IFNB1 CXCL8 IL1B MAPK1 TNF HEL110 IFNA1 CD14 IL1A TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 SMAD4 WWTR1 SPARC TGFBR3 POSTN CTGF TGFBR2 TGFBR1 YWHAG RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling AFDN GNG3 GNG2 GNG5 GNG4 GAB2 GNG7 GNG8 ZAP70 KDR SHC1 KSR1 PDGFRA RRAS2 PLA2G2A SOS2 MET SHC4 LAT SHC2 PTPN11 SHC3 STK4 FLT3 FGFR2 PRKACG RAC3 PLA2G5 PLA2G6 PIK3R3 RAB5C PLA2G4B PAK6 PAK4 MAPK10 MAPK9 MAPK8 CALML6 CALML3 ARF6 CALML4 EXOC2 HTR7 RASGRP3 RAP1A RRAS PIK3R2 PIK3R1 RASGRF1 NF1 GRIN2B SYNGAP1 IKBKB ABL2 RAC1 HRAS KSR2 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D RALA PLA2G1B PLA2G4E PLA2G4C PLA2G3 EGFR PLA2G10 PAK1 FLT1 INSR RELA FGFR4 NRAS IGF1R GRIN1 RASSF1 AKT3 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAB5A BCL2L1 ETS2 RAF1 TNFSF6 EPHA2 PRKCB GNG10 GNGT2 PRKCA NTRK1 RASGRP4 KIT REL RASGRF2 TIAM1 RASA2 PIK3CD NGFR CHUK PLCG2 PLCG1 IKBKG RAB5B GNG12 GNG11 PIK3CA NFKB1 GNG13 CSF1R NTRK2 GNB2 ARHA GNB1 BAD PLA1A GNB4 RASAL1 GNB3 RASAL3 PLCE1 TTBK1 GNB5 RASA4B RALBP1 CALM1 PLAAT3 CDC42 RASA3 RASA4 RIN1 RAPGEF5 PLA2G2F PLA2G2E FGFR1 PLA2G2C FOXO4 PLD2 GNGT1 FLT4 RALB GRB2 SHOC2 SOS1 FGFR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CHST7 EXT1 CHST1 CHPF CHST3 XYLT2 XYLT1 EXTL2 HS6ST1 EXTL1 HS6ST2 CHSY1 HS6ST3 CHSY3 CSGALNACT1 NDST3 CHPF2 B3GAT3 GLCE B3GAT2 B3GAT1 CSGALNACT2 B3GALT6 HS3ST1 HS3ST3A1 EXT2 UST CHST11 CHST12 HS3ST2 CHST13 CHST14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 SMAD2 CASP9 CASP3 STAT1 BAX MRE11A CDC25B MSH6 RAD50 MSH2 BLM CDK4 MYC CDK2 CASP8 BARD1 ATF1 MAP3K5 BAD PLK1 BCL2 CDKN1B BBC3 NOXA1 MDM2 ATM ATR POU2F1 BACH1 CDKN1A PTEN BRCA1 RB1 JAK1 CDKN2B CDC2 CHEK2 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell SPRYD4 AP3D1 PHLDB2 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 LAMTOR3 LAMTOR5 TUSC2 LTN1 CPOX ARID4B CALCOCO2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ERBB3 POGLUT3 VPS39 KPNA3 EIF4E AXL MYLIP TPM3 TPM1 GRIA2 STX7 UBE4A ATG9A CDKAL1 RAB30 GPD2 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP MCL1 CCND1 CD164 BRPF3 HMGA1 SLC4A10 NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 CHMP2A SRPRB DKFZp761E1322 PICALM SLC25A1 DOCK5 TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 HSDL1 DSG2 ARID1A TXN2 RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 NXN UHRF1 HSD17B12 GNA13 DNAJB1 CAND1 PPP3CA POLR2C TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 CSF1 IRS1 MAPK12 MAPK14 PPIF MTRR LPL RTN4 KIT PRKCI COL3A1 DOCK7 RARS1 HEL-S-47e MAPK7 CDK6 E2F3 ITGB4 LAMC2 FGF2 P4HA2 NELFCD CDKN1A TMEM87A VSNL1 FSTL1 CA12 CAMTA1 ACVR1B PPIB HYAL3 ERBB2 CDKN1B LAMC1 C1QBP TNFRSF10B ITGA2 CCNG1 SNAP23 PTPRF COL1A1 SPARC SYPL1 THBS1 GPAM CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 GFPT1 ERG ATP6V0E1 CPNE8 VEZT TMEM41B EHMT1 SLC38A5 CLDN1 PWP1 ABCG2 KRAS CHORDC1 RAVER2 COL1A2 CIAO2A SEC62 NOTCH2 CDK5RAP3 NOTCH1 BCL2 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B GJA1 FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 HES1 HACD3 MRPL20 SLC7A11 BACH1 COMMD9 RDH10 GRPEL2 SNX6 SLC38A1 GSTM4 RAB27B MOV10 POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B RNP24 NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MRC2 PANX1 COIL SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC MRPS24 ATP2A2 ELMOD2 TMT1A AP3B1 SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN SSNA1 AMIGO2 NAPG HEL-S-66 PTPA NT5E PGRMC1 PPP1R7 USP1 SHOC2 SRSF10 MPZL1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS IL12A VIP IL2 IL4 IL5 IFNG TGFB1 CD80 IL10 CTLA4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 POMC CDKN1B PPARG YAP1 CRP VEGFA CDKN1C INS FOS CDKN1A IL6 CREB1 BCL2L11 VAMP2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 EGFR RAF1 SMAD4 TGFB1 TGFBR3 AXIN1 NRAS TGFBR1 TSPAN8 CTNNB1 HGF MFGE8 DKK4 ERBB2 KRAS MET WNT3A HRAS MTOR TGFBR2 TGFA APC CD133 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion MYL11 MYL5 MYLK MYL7 ITGB1 LAMB3 CCND2 TLN2 TXK LAMB2 MYL12A MYL12B MYL10 VASP SRMS CAV3 TNK1 PARVB VAV1 PARVG VAV2 ARHGAP5 DOCK1 SRC STYK1 KDR SHC1 c-fgr PDGFRA ZYX PDPK1 HGF ERBB2 FLNA MET FYN SHC4 SHC2 SHC3 PDGFC HEL-S-28 EGF ITGB3 ITGA2B CCND3 RAC3 LAMC1 PXN IBSP PIK3R3 ITGA1 PAK6 PAK4 PIP5K1C ITGA2 COMP BLK CCND1 ITGA4 MAPK10 COL1A1 ITGB7 LAMA5 MAPK9 MAPK8 PPP1CC THBS1 PPP1R12B HEL-S-80p VTN RAP1A PPP1R12C TLN1 PARVA CRKL SPP1 ACTN1 ACTN4 PIK3R2 PIK3R1 LAMB1 RAPGEF1 RASGRF1 PTEN RAC1 HRAS EGFR PAK1 TNC FLT1 PDGFA BRAF IGF1 VEGFA IGF1R CTNNB1 EMP2 AKT3 MAPK1 MAPK3 COL1A2 MYLK2 MAP2K1 PDGFD BCL2 RAF1 ACTG1 HEL114 PRKCB PRKCA COL2A1 ARHGAP35 MYL2 RELN VEGFB VEGFC GSK3B VEGFD XB PIK3CD TNR CRK COL4A2 BIRC2 ROCK1 COL4A1 BIRC3 ROCK2 JUN COL4A4 COL4A6 PIK3CA CAV2 CHAD ARHA BAD CDC42 FLNB COL5A3 COL5A2 ITGB5 ITGB4 TNK2 LAMC2 PS1TP5BP1 PTK6 ITGB8 ITGAV ITGB6 VAV3 VWF ITGA7 ITGA6 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 MYLK3 SOS1 THBS3 MYLK4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation AP3D1 TM6SF1 HTT SPCS3 HOMER2 AGAP2 RAMAC ZNF592 PDE8A RNMT WDR73 BNC1 BTBD1 GOLGA6L4 ADAMTSL3 SH3GL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB DNM3 RYR1 NMBR RYR2 EGF AP3B2 SPCS2 RAF1 SPCS1 ALPK3 ZSCAN2 SYNJ1 SHANK3 SHANK1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 CYP11A1 HSD11B2 SRD5A2 POR CYP21A2 STAR H6PD HSD3B1 HSD17B3 CYP17A1 CYP11B2 HSD3B2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair TDG POLE4 SMUG1 HMGB1 PARP2 PCNA PARP1 FEN1 MPG PNKP OGG1 UNG POLD3 POLD4 NTHL1 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 POLD2 NEIL2 APEX1 POLE3 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling ACTA2 COL1A1 CXCR4 MAPK8 TGFB1 STAT1 STAT3 SOCS5 CCL11 TNFRSF1A NFKB1 IL4 SOCS1 IL19 CCNB1 MAPK1 TNF RAC1 MAPK3 JAK1 IL20RA MAPK14 IL20RB MUC5AC G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling RHPN2 HEL-S-15 MYBPH PIK3CD CIT MAPK10 ARHGDIG WASL PIP4K2A MYL1 ROCK1 WAS ROCK2 SH3RF1 PIK3CA ARHGDIB HEL-S-80p LIMK1 ARHA PIK3R2 CDC42 CALM1 IQGAP1 TNK2 CYFIP1 RPS6KB1 PKN1 GNA13 ARHGEF1 RAC1 CFL2 PFN1 RTKN 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation LEP POMC GHSR GHRL MC4R SIM1 INSR LEPR BDNF INS NTRK2 AgRP NPY CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE HSD3B2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT2 GALNT16 GALNT1 B3GALT2 B3GALT1 B4GALNT1 B4GALT1 CERS3 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 KDSR T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFD IDO1 TGFB1 CXCL12 PDGFA ARG1 VTCN1 VSIR TIGIT VEGFA B2M IL10 SHH TNFRSF4 HAVCR2 IL13 ENTPD1 TNFRSF9 FAS HLA-A PDCD1LG2 IL4 IL6 FAP NR1i1 PDGFD CTLA4 CCL17 PDCD1 PDGFC ICOS CCL22 TNLG5A CXCR4 LGALS9 CD40 TNFSF6 CD80 CD40LG TNLG2B CD226 NT5E VEGFB VEGFC NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining PRKDC POLL WRN POLM NHEJ1 XRCC5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome MMP9 CAMK2A CDKN2A BDNF SRC SHC1 AGAP2 HCN1 FYN RPTOR PTPN11 DEPTOR MLST8 EIF4E GRIA2 GAD1 EPHA4 RPS6KB1 RHEB AKT1S1 DAG1 TSC2 APP TSC1 ARAF ARC CLTB DLG4 CYFIP2 GRIP1 CPT1A SH3GL1 GRIP2 ARHGAP32 ABCD3 KCNC1 DLGAP3 TTI1 ALDH5A1 TBC1D7 PICK1 EPS8L1 NF1 CYFIP1 FMR1 GRIN2B SYNGAP1 PTEN PPP3CA SHANK1 SLC6A1 ALDH3A2 HOMER1 MAP1B PLCB1 BRAF CAMK1 AKAP5 GRIN1 MAPK1 KRAS KCND2 MAP2K1 MAP2K2 RAF1 EIF4G1 ABAT EIF4EBP2 DUSP3 PRKCA DICER1 EEF1A1 PRKAR1A TARBP2 AGO2 DKFZp762B153 GPHN RAP1GAP PLCG1 NTRK2 GABRG2 SH3GL3 MTOR EIF4A1 CLTC CLTA AP2A1 GABRB2 AP2S1 CLTCL1 PPP2R5B AP2M1 CREB1 CNR1 GRB2 SOS1 PTPN5 CAMK4 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism EBP CD36 CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR FDFT1 DGAT1 SQLE ABCG8 ABCG5 APOA4 MTTP APOB LDLR ACAT2 HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK MVD SLC27A4 SAR1B MGAT1 NPC1L1 FABP2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 PTGS1 NR1C1 MVD PTGS2 WNT1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CREBBP HDAC10 SRC STIM1 NRG1 GRM6 GRIA2 GRIN3B GRIN3A GAD1 GRIA3 GRIA4 SDCBP STAT3 CRTC1 HEL-S-162eP ARC PDIA2 DLG4 GRIP1 SLC6A13 DLGAP3 SLC6A11 PICK1 FRMPD3 ADARB1 CACNG8 SLC6A12 CACNG2 EFNB2 NETO2 CPEB3 CABIN1 ARHGEF9 GABRR3 SLC1A1 GRM3 GABRR1 NPTN NRXN3 GRIN2B ADIJ ADII NWD1 SLC6A8 SNX27 GLS2 ATAD1 SYVN1 LHFPL4 SLC6A1 SNX14 HOMER1 PLCB1 STAT1 CDH2 GRIN1 GRIK5 SLC1A2 GRIK3 GRIK1 MAPK1 GRM2 ERBB4 GRM4 MAPK3 GRM8 MAP2K1 FFAR1 ORAI1 MBD5 SUMO1 HDAC1 ABAT GNA11 SLC7A11 PRKCA PPP2CA DKFZp762B153 PIG59 GRIK2 GABRG2 SH3GL2 SLC1A3 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG1 SLC32A1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 CS ALDH3A2 ACSS2 ACO2 ALDH9A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT PRF1 FOXO1 GATA2 MYC CCL5 TNF CCL2 CCL4 CCL1 ADAM17 ADAM10 FCGR3A IFNG CD226 CSF2 MICA BMI1 KLRK1 NCR3LG1 MICB CD96 NCR1 CCL3 NCR3 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAP3K21 MAPK9 MAPK8 ARAF BRAF MAP3K1 PARP14 MAP2K3 MAPK1 MAP2K4 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 PARP1 RAF1 MAP3K8 MAP3K7 MAP3K12 TNKS ATF4 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA LAG3 TGFB1 CXCL12 CCR2 VEGFA NRP1 HLA-DRB1 KDR FAS CSF1R IFITM2 CSF1 CCL5 CCR5 BAG3 HLA-DRA CCL2 CTLA4 CXCR4 TNFSF6 CD80 ITGB6 CSF2 CXCR3 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN1 PLAGL1 PCM1 ACTR1B KIAA0753 CEP170 BMERB1 DCTN6 OFD1 NDE1 ABCC6 DCTN4 MARF1 CEP20 DCP1A GATA3 ACTR10 DCP2 RAPGEF4 RAP1A DISC1 PLK1 ABCC1 PAFAH1B1 PLAG1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 PIK3R5 CACNA1A PRKCZ MAPK8 INSR PDX1 SLC2A2 SURF1 PHKA2 IRS1 IKBKB SOCS4 MAPK1 TNF INS-IGF2 MAFA MTOR FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 FOXP3 IL6R IL2 IL7R IL6 IL2RG STAT3 STAT5B CD80 IL2RA IL6ST IL2RB CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 IKBKB CHUK RELA REL NFKBIA IKBKG NFKBIE ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 LMF1 LDLR PLTP GPIHBP1 LPL ANGPTL4 APOA5 ANGPTL8 APOC2 ANGPTL3 LIPC APOA2 SEL1L RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 RALBP1 EXOC2 EXOC8 YBX3 KRAS RAC1 NRAS RAC3 HRAS RALA WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath GSK3B MAPK9 MAPK8 TSC2 CSNK1D TSC1 CSNK1G1 AXIN1 ROR2 FRAT1 CSNK1A1 CSNK1E CTNNB1 LRP5 NLK MAPK1 LRP6 SOX1 ARHA RYK NFATC2 ROR1 PI4K2A MTOR APC CDK6 CTBP1 BCL9 ARRB2 PPARG LEF1 PRKCB GSK3A MAP3K7 TCF4 DVL1 STM7 DVL2 TCF7L2 PRKCA TCF3 DVL3 RAC1 CCND1 GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RAD1 RAD9B CHEK1 RAD9A ATRIP RPA3 RPA1 HUS1 ATR TOPBP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis GPC6 COL1A1 COL3A1 SPARC YAP1 SNAI2 EDNRA TEAD4 TWIST1 PBX3 THBS2 TEAD2 TEAD3 NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway ABCC5 HGF NRG1 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 TGFB1 TXN SERPINA1 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 SLC2A3 GSTM3 SLC2A2 ABCC3 SLC5A1 HEL-S-128m SLC6A5 SLC5A2 SLC6A7 SLC6A20 SLC6A8 SLC6A9 DNAJB1 SLC5A5 GSTM5 SLC6A1 EGR1 SLC6A2 TGFBR2 SLC2A14 SLC6A19 SLC2A11 UGT2B7 ABCC2 SLC2A10 SLC6A18 SLC2A13 SLC2A12 GSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A8 HBEGF RXRA HEL-75 GCLC GSTM2 NFE2L2 GSTA5 GSTA4 CYP2A6 GSTA3 SLC6A3 SLC39A9 UGT1A1 EPHA2 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC7A11 ALDH3A1 FTH1 SLC39A8 SLC2A9 GSTM4 SRXN1 SLC2A6 SLC2A7 SLC2A8 KEAP1 MAFG ME1 SLC39A14 GPX2 HEL-S-25 FTL HEL-S-22 SLC5A12 SLC5A10 HMOX1 UGT1A4 UGT1A7 TXNRD3 MAFF ADH7 GCLM FGF13 HSP90AB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 APP PSEN2 SIRT1 PSEN1 GDF8 PSENEN BACE1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 ID2 ID3 CCNE1 ID1 PAX8 RBL2 RBL1 RB1 CDK2 PAX2 MYOD1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGV PIGY PIGM PIGC DPM2 PIGB PIGW PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index TLX2 HDAC5 STAT3 LEFTY1 TLX1 TLX3 LEFTY2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 LTC4S PTGS2 ALOX5 ALOX15B ALOX15 ALOX5AP PLA2G5 PLA2G6 PTGS1 PTGIS PLA2G4B PRXL2B PTGES OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response MAPK10 CASP9 CASP3 BAK1 APAF1 TRAF3 TRAF2 TRAF6 C5AR1 MAP3K1 CDKN1C NFKB1 MAP2K4 TNF MAPK13 BAD GADD45A PCNA C1R CDC42 BCL2 CDKN1B C1QB C1QA TNK2 C4B_2 C2 CDKN1A C3AR1 TNFRSF1B BAG4 CR2 TRAF1 NFKBIE CYCS C1QC HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PLCB4 PRKD3 PLCB1 EGFR SMAD2 PLCB2 FLT1 INSR CDH6 FGFR4 CDH2 CDH16 IGF1R KDR PDGFRA CTNNB1 PRKAA2 MET PRKAG1 FLT3 PRKAG2 PRKAG3 FGFR2 PRKAA1 LEF1 PRKACG EPHA2 PRKAB2 PRKCH PRKCB PRKAB1 GNA11 PRKCE PRKCA NTRK1 TCF7L2 TCF7L1 CDH9 KIT CDH8 PRKAR1B GNAL PRKAR1A CDH4 PRKCI CDH10 PRKCQ CDH11 CDH12 CDH15 CDH17 CDH19 NF2 PRKCZ CDH24 NGFR WWTR1 YAP1 GNAI3 CSF1R NTRK2 ARHA GNAS MTOR CDC42 FGFR1 FLT4 CDH18 LATS1 PLCB3 TEAD4 LATS2 RAC1 TEAD2 TEAD3 FGFR3 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CCND2 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 TFAP2A WNT5B WIF1 SOST LEF1 CCND3 NKD1 NKD2 MAP3K7 DVL1 DVL2 TCF7L2 TCF3 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 MACROH2A2 ATF3 CXXC4 PORCN GSK3B CDK8 WNT2B HNRNPK NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 FRAT1 FRAT2 AXIN2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CDK6 CTBP1 FOSL1 FZD1 RUVBL1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 APC2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders TF PANK2 CYBRD1 HFE2 HAMP HEPH FTL STEAP3 FTH1 UQCRFS1 CP TFRC HFE TFR2 SLC40A1 SLC11A2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 PPP5C TSC2 PPM1D RBBP8 RNF20 MRE11A MDC1 ATMIN RIF1 CEP63 IKBKG KAT5 TRIM28 RAD50 TP53BP1 NFKB1 LMNB2 CDK2 NHEJ1 MAPK12 MAPK13 ATF2 MAPK11 MAPK14 MTOR PRKDC HMGN1 ATM RNF168 NBN ATR SMC1A RNF8 AURKB HEL-S-102 PPP2CA STK11 CDK5 CHEK2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2B P2RY6 P2RY4 P2RY2 P2RY1 LPAR4 ADORA2A LTB4R SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer SERPINB2 IRF7 CDKN2A SMAD4 INHBA BRAF IGF1 CEBPB IGF1R IL24 SRC INS MAP2K3 MAPK1 MAP2K1 MAPK14 LAMP2 IL6ST MLST8 BCL2 RAF1 ATG3 CDKN1B GABARAPL2 PLAT ATG12 SLC39A2 IGFBP5 SLC39A1 ATG16L1 SLC39A3 AKT1S1 IRF1 IL6R MAP1LC3A MAP1LC3C SQSTM1 IFNG RB1 SH3GLB1 UVRAG ATG10 BMP2 GSK3B HMGA1 CD44 COL1A1 DKFZp762B153 COL3A1 RB1CC1 SPARC TGFB1 CDC25B JUN ING1 COL10A1 GABARAPL1 THBS1 TNLG1B ATG14 ATG5 RNASEL VTN IL6 GABARAP CXCL8 AMBRA1 IFI16 CREG1 RSL1D1 ULK1 MTOR IL3 PCNA MDM2 KMT2A CDKN1A PTEN IFNB1 IL1B BMI1 HRAS CXCL1 CXCL14 IGFBP7 IL1A MMP14 CCL3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling PAK1 RELA HEL-S-81p GAB2 VAV1 SH2B3 ZAP70 GRAP2 SHC1 PDPK1 LCP2 CARD11 BCL10 MAPK1 FYN MAPK3 NFATC2 LAT ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 RAF1 MAP3K8 MAP3K7 REL PTK2B PRKCQ LCK MAP4K1 MAPK9 MAPK8 CD3G CD3E CHUK CD3D CD8A TRAF6 CRK IKBKG WAS PLCG1 JUN NFATC1 NFKB1 MAP3K14 ITK CRKL PSTPIP1 RIPK2 FYB1 PIK3R2 PIK3R1 CDC42 ICOS CBL NCK1 VAV3 FOS IKBKB CREB1 HRAS GRB2 SOS1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GCK GLS UGDH LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 CD36 BMP1 FGFR1 GLUD1 FGFR4 PSAT1 PLCG1 P4HA2 PSPH ALDH18A1 HEL-S-133P ARHA PHGDH P3H4 P3H3 PLOD1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR AGXT GLYCTK AQP9 KHK GPD1 LIPE ALDOB PC FBP1 GPD2 PFKL HEL-S-162eP ENO1 HEL-S-68p MGLL HEL-S-165mP PGAM1 HEL-S-49 G6PC1 HEL-S-87p PNPLA2 AQP7 PCK1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling OXTR PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP9 CASP3 APAF1 PINK1 UBE2L6 PARK2 UBE2L3 CASP2 DDC MAPK12 MAPK13 MAPK11 MAPK14 GPR37 UBB SEPT5 LRRK2 SLC6A3 ATXN2 HEL-S-67p CASP6 CCNE1 UBA7 TH EPRS1 SYT11 HEL-117 UBE2J2 CCNE2 UBE2J1 SNCA HTRA2 UBE2G1 UBE2G2 SNCAIP CYCS IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFD MMP9 TGFB1 CXCL12 VEGFA IL10 IL13 IL2 IL4 IL6 IL5 CXCL8 CCL5 TNF CCL28 CCL2 CXCL5 CCL20 LGALS9 IL25 REG4 IL12B IL12A IFNG IL23A IL1B IL17F CSF2 IL17D IL17C IL17B CXCL1 VEGFB IL17A VEGFC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 YES1 WWTR1 H4C9 SRRT FGF7A HIST1H4L SOX12 POU3F1 UTF1 SOX15 ZSCAN10 SOX4 SOX2 TEAD2 POU3F2 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair PCNA POLE4 RFC2 MSH6 RFC3 RFC4 RFC1 POLD3 MSH2 POLD4 POLE LIG1 PMS2 POLE2 POLD2 POLE3 RPA3 RPA1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP8 ATP6 COX17 ATP5MC2 ATP5J ATP5MC3 COX7A2 ATP5H COX11 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 SLC25A14 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HEL-S-123m SLC25A27 UCP3 UCP2 NDUFA7 NDUFA6 NDUFA5 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX4I1 COX6A1 COX8A COX6B1 COX7A1 SDHC SDHD UQCRB SDHB COX3 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 UQCRC2 SURF1 COX1 SDHA SLC25A5 SLC25A4 SLC25A6 UCP1 NDUFA13 COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 NDUFA9 NDUFA12 NDUFA10 COX6A2 HEL-S-271 ATP5IF1 COX7A2L SCO1 ND1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ACTA2 ITGB1 MAPK10 ITGB7 NF2 MAPK9 MAP4K1 MAPK8 PAK1 MAP4K2 WWTR1 YAP1 MAP4K3 SRC CTNNB1 CTNNA1 ACTG1 ITGB5 ITGB4 ITGB3 YWHAQ PS1TP5BP1 ITGB8 SGMS1 ITGB6 ACTA1 LATS1 LIMD1 TEAD4 PAK6 PAK4 TEAD2 TEAD3 HEL-S-31 ACTG2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 EGF ZEB2 LTBP1 ZNF423 BAMBI LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway SHC1 ERBB2 SOS2 SHC4 SHC2 SHC3 EGF RPS6KB2 E2F2 RPS6KB1 NBN DDB2 PIK3R3 RB1 CETN3 GADD45B GADD45G CCND1 ARAF BAX FZD10 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B GADD45A PIK3R2 PIK3R1 TNFSF11 FZD1 WNT10B WNT10A FZD3 ATM FZD2 FZD5 FZD7 FZD9 ATR FZD8 PTEN BRCA1 BRCA2 HRAS APC2 NCOA1 FGF23 EGFR BAK1 MRE11A BRAF NRAS IGF1 CSNK1A1 WNT7B IGF1R WNT7A RAD50 RAD51 FGF10 CTNNB1 CDK4 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 NR3A2 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 PGR RAF1 LEF1 HES1 DVL1 HES5 DVL2 FGF8A TCF7L2 DVL3 NFKB2 TCF7L1 WNT1 KIT WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD POLK AXIN1 AXIN2 SKP1 JUN WNT16 PIK3CA SP1 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC CSNK1A1L CDK6 JAG2 E2F3 PARP1 FGF18 FGFR1 FLT4 HEY2 FGF2 FGF7B FGF7A FOS DLL3 DLL4 CDKN1A FGF5C GRB2 SOS1 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes MMP9 SMAD2 ANGPT1 MAPK9 MAPK8 KITLG TGFB1 RELA CXCL12 RELB TGFBR1 DKFZp781O1323 KDR NFKB1 MAPK1 MAPK3 SMAD1 NOTCH3 NOTCH1 SMAD9 CXCR4 EPHB4 FLT4 EPHB2 DLL4 NFKB2 HIF1A KIT ACVRL1 REL CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYL11 TNNT1 ACTA2 MYL3 TNNT3 MYH8 MYH4 MYH7 MYL1 TNNC1 TNNI1 HEL-S-273 HEL-S-108 RYR1 RYR2 ACTG1 TPM3 TPM1 RYR3 PS1TP5BP1 MYH6 ACTA1 MYH13 TNNI2 MYL2 TNNI3 TNNC2 MYH1 ACTG2 MYH2 MYL6 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine AANAT SPR PAH MAOA ASMT JDP1 PTS PNMT TH DHFR DBH NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 RELA DDX3X TRAF3 CASP10 MAP3K1 ISG15 TNF IFNK MAPK12 MAPK13 MAPK11 MAPK14 NFKBIA TBKBP1 NFKBIB IKBKE ATG12 MAP3K7 IFNE RIPK1 IFNG TANK MAPK10 MAPK9 MAPK8 OTUD5 CHUK CXCL12 TRAF2 TRAF6 DDX3Y TBK1 DHX58 IKBKG TRIM25 AZI2 SIKE1 RNF125 NFKB1 CYLD PIN1 ATG5 CXCL8 MAVS SNW1 CASP8 RIGI FADD TRADD IFNB1 IKBKB MITA NLRX1 IFNA1 IFIH1 IRF3 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 LBR HMGCR NR1H2 CH25H FDFT1 IDI2 PLPP6 FADS2 SCD CYP7A1 CYP27A1 MYLIP ELOVL5 ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK HMGCS1 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP6 ATP5MC2 ATP5J ATP5MC3 ATP5H NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 HEL-S-123m NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COXFA4L2 ATP6AP2 NDUFS8 NDUFS3 COXFA4 NDUFA11 NDUFA9 NDUFA10 HEL-S-271 ND1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 NF1 KRAS NRAS BRAF HRAS PTPN11 GRB2 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling GSK3B CREBBP CASP9 PDGFA IKBKG FOXO1 PIK3CA NFKB1 CTNNB1 AKT3 KLK3 MAPK1 KRAS BAD MAP2K1 MTOR NFKBIA MAP2K2 BCL2 RAF1 CDKN1B MDM2 CDKN1A GRB2 CCND1 SOS1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IF2B1 IL23R IL17RC STAT3 IL12RB1 IL12B TYK2 CXCL8 IL23A IL1B IL17F HLA-C TNF CCL20 CXCL1 IL17A CCR6 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM1 RYR1 MYLK PLCB1 PPP1R14A MYL1 ROCK1 ROCK2 IL13 GDI1 ADRB2 HEL-S-80p ARHA OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 NFKB1 IKBKB CHUK MAPK1 RELA ITGB3 MAP3K14 SPP1 MAPK3 MAP2K1 ITGAV HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG3 RB1CC1 ATG12 WIPI1 ATG16L1 MAP1LC3A ATG5 ZFYVE1 ATG16L2 ATG10 ULK2 MTOR ULK1 PIK3R4 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 ABCC2 AKR1D1 AKR1C4 SLC27A5 SLC51A HSD3B7 ABCB4 SLC51B ABCB1 BAAT ABCC3 CYP7B1 SLCO1B1 FABP6 SLC10A2 AMACR ABCB11 SLC27A2 ATP8B1 HSD17B4 CYP7A1 ABCD3 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 HSD17B2 F13B HSD3B1 HSD17B3 HSD17B7 CYP17A1 HSD17B4 HSD17B1 HSD3B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB4 PIK3CD PLCB1 PLCB2 TSC2 TSC1 YAP1 ROCK1 PKN2 PIK3CA AKT3 MAPK1 ARHA MTOR PIK3R2 MOB1A PIK3R1 PKN3 PKN1 PIK3R3 LATS1 PLCB3 TEAD4 LATS2 TEAD2 TEAD3 TRIO SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways CALCA HEL-S-14 MYLK PLCB1 GNAI1 MYL1 CAD HEL-S-7a GNG13 EDNRA RAMP1 GNA15 MAPK1 NPY GNAS MAP2K1 COX2 CALCRL GNB5 ECE1 EDNRB CALM1 ADRB1 NPY1R RIIAD1 ATP2A2 RAF1 ADRA1A EDN1 PRKCA PTGIR LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 CS SLC19A2 NONO SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B CYP2C8 CYP8B1 COX1 PLCB1 ALOX12 LTC4S PTGS2 CYP2C9 ALOX5 CYP2B6 ALOX15 HPGD CYP7B1 CYP4F2 GPX4 FADS2 PLA1A CYP7A1 EPHX2 PRXL2B CYP27A1 PTGES VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism HEL-S-53e RXRB CD36 RXRG HEL-S-4 CYP26A1 SULT1A1 SULT2B1 ADH1A CYP26B1 RLBP1 RPE65 DGAT1 SDR16C5 RXRA MAPK1 RDH12 ABCG8 AWAT2 ABCG5 LRAT BCO1 SCARB1 RDH8 ALDH1A3 CRABP2 RETSAT RARA CRABP1 LPL DHRS3 RBP7 RBP4 RBP2 RBP1 RDH5 CYP2E1 ALDH1A2 NR1B3 RDH10 NPC1L1 RARB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 ST3GAL5 A3GALT2 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 TNLG7C DKK1 EDARADD DKK4 LTB WNT3 PTCH1 RELB EDAR SHH SOSTDC1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH GH1 GNRH1 SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 HEL-S-53e GLYCTK KHK HEL-S-49 SORD ALDOB G6PC1 FBP1 PFKL SLC2A2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI NEDD4 TGFBR2 TGFBR1 ATG16L1 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing SRPK2 PPM1G RNMT YBX1 SUPT5H HNRNPH1 NCBP1 NCBP2 SMC1A SRSF9 TMED10 PTBP1 METTL3 SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A NONO PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 HNRNPD SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA FUS SNRPB DHX8 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 WDR57 SFRS3 CLK4 SFPQ LSM2 CLK2 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 DICER1 CSTF2T U2AF1 PABPN1 POLR2A U2AF2 TRA2B SNRPB2 SF3B1 DDX1 SF3A1 SF3A2 HNRNPK SPOP HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRPK1 SRP54 DHX15 PRPF40A SRSF10 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB4 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 RETN RELA CHUK PLCG2 PLCG1 IKBKG PIK3CA NFKB1 IL6 AKT3 CXCL8 MAPK1 TNF MAPK3 MAPK14 NFKBIA PLCE1 IL12B IL12A PLCB3 IKBKB LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis MMP9 CXCL2 CCR2 PDGFA IGF1 CEBPB CCL11 HGF CCL5 TNF SFTPC CCL2 CCL4 TGFA EGF BMP7 NFE2L2 IL12B TERT TIMP1 CALCA TGFB1 CSF3 FAM13A SFTPA2 MT2A KPG_011 ATP11A CTGF RTEL1 DPP9 STN1 CMA1 IL13 MUC5B HMOX1 IL4 IL6 IL5 SERPINA1 CXCL8 SPP1 FGF7 CCR3 ELMOD2 PTX3 SFTPA1 FGF2 GREM1 EDN1 MMP2 IL1B CSF2 SKIL CCL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK HEL-S-162eP PFKL ENO1 ENO2 PFKM ENO3 HEL-S-68p MPC2 PGAM2 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-30 HEL-S-87p HK2 PCK1 SLC2A4 PDHA1 MDH2 GOT2 PKLR ALDOB PC FBP1 SLC2A3 SLC2A2 LDHB MPC1 HEL-S-133P DLAT HK3 G6PC1 HEL-S-32 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO GOT2 AGXT SLC26A1 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FBP1 VEGFA FOXO1 PIK3CA HEL-S-68p KDR MYC HIF1A PGAM1 HEL-S-133P OTUD7B G6PC1 OTUB2 USP37 U2AF2 USP44 SIRT7 MTOR HK2 VHL USP28 USP19 OTUD6B ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 KCNQ2 BRSK1 SEMA3A ANK2 L1CAM SCN5A SPTAN1 PRRT2 CSNK2A1 EIF2A CSNK2A2 SCN2A DDIT3 CSNK2B SNAP25 ATF4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap MTR CTH GCLM CBS METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 ANXA2 MTTP APOB LDLR APOE LPL ABCA1 LIPG APOC2 LIPC APOA2 PCSK9 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BIRC5 HEL113 APP AXIN1 HEL-S-89n NFKB1 THBS1 SOCS3 NRG1 YBX3 MAPK1 JUND TNF RIPK2 F2R ERBB3 GCLC ERN1 CTNNA1 IL7R CDKN1B CUL5 APOE BEX3 RNF7 NQO1 HELLS HDAC1 NET1 CARD14 TNFRSF21 RPS6KB1 PKN1 VAV3 HEL-S-7 CDKN1A SQSTM1 HEL-S-102 PTK2B TNFRSF10B TRAF1 HSPD1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DCTN1 YWHAQ DCTN6 TH PAFAH1B1 DCTN5 DCTN3 HEL-S-1 YWHAG NDEL1 DCTN4 HEL-S-77 YWHAZ DDC PPP2CA HEL2 CDK5 DBH DISC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MYLK PIP4K2A VAV1 DOCK1 PDGFRA RRAS2 SOS2 WASF1 EGF FGFR2 RAC3 PXN PIK3R3 STM7 ITGA1 PAK6 PIP5K1A PIP4K2B PAK4 PIP5K1C MYL3 WAS ARHGEF4 RRAS CYFIP2 BDKRB1 PIK3R4 ACTN1 PIK3R2 PIK3R1 GNA13 RAC1 APC2 CD14 FGF23 EGFR PAK1 MYL1 FGFR4 ARHGEF7 PDGFA BRAF NRAS CHRM1 FGF10 BDKRB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAF1 ACTG1 HEL114 F2 FGF8A ARHGAP35 CFL2 FGF6B PFN1 EZR HEL-S-15 PIK3CD CHRM2 CHRM3 CRK ROCK1 ROCK2 GNG12 PIK3CA TMSB4X LIMK1 ARHA FGF20 FGF22 FGF7 FGF21 FGF8 F2R FGF9 FGF16 APC FGF14 CDC42 PIK3R5 FGF13 FGF18 FGF12 IQGAP1 FGFR1 PIK3C2G PIK3C2A PIK3C2B PS1TP5BP1 FGF2 FGF7B NCKAP1 CHRM4 FGF7A CHRM5 HEL70 MYH10 RDX RASSF7 ARHGEF1 ARPC5 MAPK6 SSH2 SSH3 MAPK4 BRK1 FGF5C PIP5KL1 FGD1 CSK WASF2 BAIAP2 MOS SOS1 ABI2 FGFR3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 NFE2L2 MAPK8 HEL-S-22 NQO1 CES1 ABCC6 JUN ABCC3 FOS HMOX1 ABCG2 EPHX1 MAPK12 MAPK13 SRXN1 MAPK11 GCLM MAPK14 NQO2 KEAP1 GCLC IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling MMP9 ACTA2 RORC DCSTAMP SMAD2 MAPK9 MAPK8 CASP3 RELA STAT1 STAT3 BAX IL10 JUN NFATC1 PIK3CA TYK2 ATP6V0D2 SOCS3 IL6 CXCL8 MAPK1 TNF DDIT3 MAPK3 MAPK14 NFKBIA COX2 CCL20 IL33 TNFSF11 EPHA3 DEFB4B MPO CTSK IL10RB IL1B CSF2 JAK1 IL20RA IL17A IF2G MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IRAK1 TIFA TLR4 UBE2V1 MYD88 TRAF6 TLR1 JUN NFKB1 TLR10 TLR5 HEL-S-71 TLR9 TLR8 TLR7 IL1A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells KIR2DL1 KIR2DL3 ELF3 NLRP7 NLRP2 VAV1 PLCG1 PRKCA LCP2 IFNG CSF2 HLA-C TNF RAC1 FYN LAT TYROBP PRKCQ SYK PTPN6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR1D2 RORC RORA RXRB NR2F6 RXRG NR2E1 NR2F1 NR0B1 NR5A2 NR1H2 NR1C1 NR1A2 RXRA NR1I3 NR1i1 NR5A1 ROR1 NR2F2 NR3A2 NR1i2 PGR RARA NR2C2 NR2A1 PPARG NR3C1 ESRRB NR1C2 NR1B3 NR1H3 THRA ESRRA RARB FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 LMF1 LDLR PLTP GPIHBP1 APOA5 APOC2 LPL LIPC APOA2 SEL1L SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network SELENOK PTGS2 RELA INSR CRP HEL-S-97n FLAD1 PRDX3 PRDX5 INS HEL-S-2a TNF GPX1 CCL2 HEL-S-44 HEL-75 SCARB1 APOB SERPINA3 LDLR SAA4 HBB MTR PLAT PLG HEL-S-302 SELENOF MPO SELENOI SELENOH ABCA1 SEPHS2 FGA HBA2 GPX6 F2 PTGS1 SELENOO HEL-S-78p NFKB2 F7 SELENON IFNG SELENOM ALB SELENOP SAA1 SELENOW SAA2 GPX4 SELENOV SELENOT MSRB1 SELS GPX2 ALOX5 ALOX15B ALOX5AP DIO1 CBS TXN NFKB1 TXNRD3 IL6 CTH XDH GPX3 TXNRD2 IL1B KMO KYNU DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis OXCT1 HMGCS1 ACAT1 ACAT2 BDH1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 HFE2 HAMP BMP6 ID1 HFE TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma ELOC BIRC7 CREBBP TGFB1 EP300 TFEB VEGFA CTSK SETD2 FH CADM2 DVL2 ARNT2 CDKN1A PRCC RBX1 COL21A1 EGLN1 HIF1A EGLN3 EGLN2 VHL TGFA SFPQ BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 GSTM1 MPO CYP2E1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders XDH ADA DGUOK HPRT1 TPMT RRM2B ADSL HEL-S-70p PNP MOCOS AMPD1 PFAS PAICS APRT AOX1 IMPDH1 ADSS 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV SDF2L1 CAMK2A NEDD4 PPIB RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RNF19B RPS12 VPREB1 RPS9 CWC22 AQR RPS7 RPS8 CRNKL1 RPS5 PDIA4 RAB36 DNAJB11 RPSA PPIE RPS6 SNRNP200 GNAZ CD79B UBA6 CABP1 CD79A AK8 CWC15 TDRD3 GGTLC2 ZNF280A RPS15A HEL-S-107 RPS19 ARIH1 RPS3 CCDC116 BUD31 RPS2 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A RILP UGGT1 RPS26 PPIL1 CDC5L RPS28 IGLL5 XAB2 CHEK1 RPS29 YPEL1 PPIL4 RPS20 PPIL6 RPS21 RPS24 RPS23 IGLL1 PARK2 UBE3A UBE2L3 HEL-S-89n IQUB HEL-S-99n ROPN1L RSPH6A PDIA2 DNAJB13 NME5 DYDC1 RSPH9 RSPH3 MDM2 XBP1 RSPH14 SNRPD2 SNRPD1 SNRPD3 PAK1 SNRPG SNRPE SNRPF CAMK1 SNRPB FAU PRPF8 MAPK1 WDR57 HEL-S-125m DHX16 RPS11 RPS27A SNRPA1 SF3B5 SF3B2 SNRPB2 SF3B1 SF3A1 ELOC SF3A2 PHF5A HYOU1 RBX1 SNW1 CANX BCR SOX9 CBL PTPA CAMK4 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy STX1A CAMK2A DAG1 RAB1A SCN8A ZNF547 TRAPPC3 PRRT2 GIGYF1 TRAPPC6B KCNQ5 NEDD4 AKAP5 SCN2A SCN4B RAB11A SNAP25 KCNQ2 CALM1 KCNQ3 FGF13 FGF12 PRKCE BACE1 VAMP2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 HSD17B2 HSD3B1 HSD17B3 SULT1A1 UGT1A1 CYP17A1 HSD3B2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation NCKAP1L VAV1 GATA2 KLF1 CSF1 CD34 NFATC2 MYB NOTCH1 MUC1 CXCR4 RUNX1 SPI1 ITGB3 LEF1 ITGA2B XB KITLG CSF3 EPO TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 GATA1 ABO MXI1 NFE2 IL6 IL5 RIOK3 NR1A2 MHC2TA FLI1 ARHH GP9 TPO HES6 IL3 PIM1 LYL1 FOS IL1B CSF2 ACVR1B FOSB IL1A EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 IL1B PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CSRP2 CTNNB1 CDK4 SOX4 RB1 PMAIP1 MACROH2A1 CCND1 MED1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease HBA2 TLR4 IL18 HBB IL1B BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 LDLR FGF8A ABCB11 MAPK1 FGFR4 ABCG8 MAPK3 ABCG5 FXR1 CYP7A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling RAF1 EPOR STAT1 STAT3 CISH EPO SRC SHC1 SOCS1 IRS1 PTPRC MAPK1 STAT5B MAPK3 PTPRU MAP2K1 GRB2 MAP2K2 SOS1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PIK3CD PTGER3 EGFR PTGS2 BRAF NRAS SRC PIK3CA AKT3 MAPK1 KRAS PTGER4 MAPK3 HRAS PLA1A PTGER2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR STAT3 MAPK1 MAPK3 JAK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL6 STAT2 HEL-S-10 STAT1 STAT3 JAK1 IL10 IL10RB IL10RA IL1A CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR NRAS IGF1R INS PIK3CA CDK4 AKT3 IRS1 ERBB2 CDK2 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 PIK3R5 CDK6 RAF1 CDKN1B PIK3C2G PIK3C2A PIK3C2B CCNE1 PIK3R3 CDKN1A HRAS CCND1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis HEL-S-53e TGFB1 ASCL1 STAT3 CDKN1C NKX2-2 SHH DDC GBX2 MSX1 SOX2 FGF8 NKX6-1 PITX3 EN2 EN1 LMX1A LMX1B OTX2 FOXA2 SLC6A3 TH NEUROD1 NEUROG2 SLC18A2 WNT1 RET GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling CDKN2A CCND2 EGFR EP300 NRAS BRAF FOXO1 IGF1R SRC PDGFRA PDPK1 CDK4 AKT3 IRS1 MAP2K3 ERBB2 CDK2 MAP2K4 MAPK1 KRAS MET MAPK3 MAP2K6 MAP2K1 MAP2K2 ERBB3 RAF1 CDKN1B FGFR2 PRKCH PRKCB PRKCA RB1 CDKN2B PRKCI PRKCQ CDKN2C CCND1 SPRY2 PIK3CD MAP2K5 PRKCZ TSC2 TSC1 ARAF PLCG2 PLCG1 MSH6 PIK3CA ERRFI1 PIK3R2 PIK3R1 CDK6 MDM4 FGFR1 PIK3C2G FOXO3A FOXO4 PIK3C2A NF1 MDM2 PIK3C2B CCNE1 ATM CBL CDKN1A PTEN BRCA1 BRCA2 HRAS GRB2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A1 SLC6A19 SLC6A20 SLC36A2 CLTRN SLC3A2 SLC7A7 SLC1A1 SLC7A9 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome PCM1 MRE11A OFD1 SHH RAD50 PDE6D PDE6A FLNA PDE6G INVS NPHP3 ZNF423 RHEB DVL1 SUFU RAB8A DVL3 CEP164 BBS9 BBS7 BBS5 CEP290 ATF4 BBS4 MYO6 KAT5 RP2 TMEM216 CEP104 ARL3 ARHA ARL13B TMEM67 INPP5E MTOR BBS2 NEK8 BBS1 CETN2 CCP110 AHI-1 PARP1 ARR3 TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP41 CEP97 CC2D2A ARMC9 ATM RPGRIP1L TMEM138 ARL2 NPHP1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 B9D1 B9D2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ASL OTC NAGS GLS2 ASS1 ARG1 SLC25A13 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GALT1 B4GALNT1 B4GALT4 B3GNT5 ST3GAL5 A3GALT2 GBA2 UGT8 UGCG NEU3 NEU4 A4GALT GLA B4GALT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 GSK3B PDE4A TFAM PDE4B GUCY1B1 PARK2 HEL-S-162eP PDE4D NRF1 AKT3 PRKG1 PPARGC1A NOS2 PDE5A ZNF746 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TLR4 MMP9 CXCL2 MBP CCR2 BDNF OMG GFAP PLA2G2A FKBP1A CCL2 CDKN1B C1QB SLIT2 EPHA4 PLA2G5 PLA2G6 TNLG7A IFNG RB1 NTN1 APEX1 CDC2 MIF CCND1 CCNG1 RGMA TGFB1 FCGR2A IL2 PLXNA2 IL4 CXCL8 GADD45A SELP EFNB2 NOX4 AIF1 AQP1 LTB PPP3CA RAC1 EGR1 ANXA1 MMP12 ZFP36 IL1A SEMA6A PDYN BCAN KLK8 EGFR BTG2 HEL113 NCAN AQP4 PRB1 PTGS2 PRB2 TACR1 VCAN TNFSF13 GAP43 CD47 ACAN SLIT1 SLIT3 LILRB3 GRIN1 CDK4 MYC CDK2 MAPK1 TNF MAPK3 CSPG4 GJA1 RTN4 PRKCA IL1R1 COL2A1 GDNF E2F5 RTN4R LEP NGFR CASP3 ARG1 COL4A1 ROCK2 LTB4R IL6 ARHA NOS2 SOX9 CDC42 FOXO3A ROS1 RHOB XYLT1 FOS IL1B CHST11 CXCL1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A PPP2R2C PPP2R2B PYGB PHKG2 PYGM AGL PHKB PHKA1 PHKA2 HK2 CALM1 PPP2R1B PPP2R1A GYS2 GYS1 PPP2R2A PPP2R5E GYG1 GSK3A PPP2R5B PPP2R3B PPP2R5A PPP2R5D PPP2R5C PTPA HK3 PYGL PPP2CA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 COA3 AS3MT UQCRFS1 HEL-S-44 SDHA HEL-S-21 ND1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 PTGS2 EPHX2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A ITGB1 PAK1 CTNND2 ARHGEF7 GRIN1 RAP1A DLG4 HCN1 SPAAR ARHGAP44 SHARPIN LZTS3 ADGRL1 CDC42 SPTAN1 GRIA2 PS1TP5BP1 SHANK3 MAP3K7 GRIN2B SYNGAP1 DLGAP1 HRAS BAIAP2 HOMER1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TOMM70 IRF7 AGTR2 REN TRAF3 TRAF6 TBK1 TMPRSS2 NFKB1 CTSL MAVS RIGI ACE2 PHB2 NDUFB9 ACAD9 AGTR1 TLR7 NDUFAF1 IKBKE ECSIT TICAM1 NFKB2 CGAS NLRX1 MITA IFIH1 IRF3 TLR3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection TLR4 IRF7 CCND2 STAT2 TYK2 NFKBIA NFKBIB IKBKE CDKN1B OAS1 OAS2 CLEC4M BBC3 OAS3 IRF9 CCND3 IFNA6 IL12B MAP3K7 IL12A CCNE2 PIK3R3 STAT5B JAK3 CCND1 IL2RA IL2RB CD46 MAPK10 MAPK9 IL2RG MAPK8 CD3G CD3E STAT3 CD3D EIF3S3 BAX FCGR2B CSNK2A1 CSNK2A3 CSNK2A2 IL2 ADAR CASP8 CSNK2B PIK3R2 PIK3R1 HEL-S-103 FADD HEL-S-72p CCNE1 EIF2AK2 TRADD IKBKB JAK1 HSPA2 IFIH1 IRF3 IL1A IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 BAK1 RELA STAT1 IFNA21 TRAF3 IF1AA9 FAS CDK4 TNFAIP3 IFNA8 CDK2 MX1 LNIR CD209 BCL2L1 BCL2 RCHY1 RAB9A RAB9B TNFSF6 IFNA7 NFKB2 EIF2S1 CYCS IRAK1 PIK3CD IRAK4 CASP9 MYD88 TP73 CASP3 CHUK APAF1 TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD TLR9 TLR7 CDK6 HEL70 FOS IFNB1 IL1B EIF2AK1 EIF2AK4 IFNA1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB SLC16A7 SLC1A2 SLC4A4 SLC16A3 HEL-S-133P NUDT14 CA4 HEL-76 SLC2A3 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAP2K5 YAP1 AMOT PIK3CA NFKB1 MAP2K3 MAP2K4 MAPK1 ARHA RAC1 MAP2K6 MAPK3 MAP2K1 MTOR MAP2K2 TRIO MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYLK HEL114 LPP ITGB3 MFAP5 PLCG1 JUN ITGAV PXN TJP1 CREB1 MAPK1 MAPK3 MYL2 PRKCQ ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway KHK SORD ALDOB AKR1B1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway SLC12A2 CFTR ADCY6 FLT1 NRAS BRAF IGF1 WNT7B IGF1R PDE1A WNT7A SRC KDR CTNNB1 MYC ERBB2 PRKAA2 TNF KRAS MAPK3 MAP2K2 WNT5B PRKAG1 PRKAG2 EGF PRKAG3 PRKAA1 PRKACG PRKAB2 RHEB PRKAB1 GNA11 DVL1 DVL2 DVL3 WNT1 KCNN4 WNT3 WNT4 WNT3A STK11 CCND1 VEGFB GSK3B WNT2B TSC2 GNAI1 TSC1 FZD10 PLCG2 WNT16 GNAI3 JUN PKD1 SFRP4 GNAS MTOR SSTR2 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT9B FZD5 RPS6KA1 FZD7 WNT9A FZD9 WNT8A FZD8 FOS WNT8B IKBKB HRAS EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 LTC4S ALOX5 ALOX15B ALOX15 KPG_011 HEL-S-298 EHHADH HPGD FPR2 CYP4A22 LTB4R NR1C2 NR1C1 TRPA1 CYP4F2 CYP4A11 TRPV1 PTGR1 CYP4F12 ACOX1 ACOX3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH3 NOTCH1 MAML3 JAG2 PSEN2 ADAM10 CHUK DLK2 LEF1 MFAP1 PSEN1 MFAP2 HES1 DNER DLL3 DLL4 RRAS MAML2 MAML1 RBPJ NOTCH2 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 EBI3 GPR183 CRP TNFSF13 FOXO1 ISG15 IFITM1 MFGE8 CCL19 PTPRC TNF PAX5 ZEB2 CCL21 CXCR4 CD40 CD80 CD82 CD79A BACH2 IFIT2 C4A BLNK IRF4 CD19 CCR7 FCRL5 IRF8 TNLG7A IL12A CXCR5 CD1D SLAMF7 HEL-S-62p SH2D1A CD40LG IFNG CR2 CR1 MS4A1 CD22 IL-21 CXCL12 BCL6 TBX21 IFNAR2 IL10 IL2 IL4 IL6 BCR SYK TLR7 PDCD1 ICOS ICOSLG PRDM1 SELL CD69 HEL-S-72p XBP1 TMSB10 ITGAX MAF CXCL13 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 SELP ITGB1 KNG1 SELPLG HEL-S-62p IL6 CXCL8 C6 C7 TNF VCAM1 IL1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders UMPS RRM2B DPYS DHODH NT5C3A HEL74 TYMP HEL-S-29 RRM1 RRM2 TYMS DPYD GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GABBR2 CASR GRM2 GPRC5A GRM4 GPRC5D GRM8 GPRC5C GRM3 GRM6 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C1R MASP2 MASP1 CFD C1QB C1QA C4B_2 C2 C4A C8A CFP HEL-S-62p C6 C7 C8G C9 CD55 C1QC ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B MEF2C MEF2B MEF2D EP300 CAMK2G FOXO1 NR1C1 RXRA PRKAA2 ATF2 MAPK14 PRKAG1 PRKAG2 PPP3R1 PPP3R2 PRKAG3 PPARGC1B TFAM PRKAA1 PPARG FOXO3A UCP3 HDAC1 UCP2 SIRT1 SIRT3 PRKAB2 GABPA PRMT1 PRKAB1 NRF1 NR1C2 CREB1 PPP3CA PPARGC1A PPP3CC TFB1M TFB2M NCOA1 PPRC1 ESRRA MED1 MYBBP1A CAMK4 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNJ2 HCN2 TMSB4X ERG GJA1 HAND2 IGF1 HCN4 KCNE1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling ANGPT2 BIRC5 HIF1AN BNIP3L ANGPT1 PTGS2 BAK1 BAX EPO VEGFA PFKL HEL-S-68p BCL2A1 HEL-S-30 NOS2 BNIP3 TGFA BCL2L1 PDHA1 IGFBP1 SLC2A3 EDN1 IGFBP2 HIF1A EGLN1 HEL-S-133P PMAIP1 MCL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA NTRK2 AKT3 SORT1 KIDINS220 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 TDO2 NMNAT1 HEL-S-90n HAAO KMO KYNU AFMID T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling GSK3B CALM1 CD8B1 DYRK2 CD8A PLCG1 CSNK1A1 ZAP70 GSK3A NFKB1 IL2 PRKCA PTEN PPP3CA ITK FYN NFATC2 NFKBIA LCK CTLA4 DYRK1A PTPN6 PDCD1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO3A1 SLC16A2 SLCO4A1 SLCO1A2 SLC16A10 SLCO1C1 SLC7A5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation TAF5 GTF2B GTF2H2C_2 TAF9 CCNH GTF2E1 GTF2E2 GTF2H2 GTF2F2 POLR2B GTF2H3 POLR2F POLR2G POLR2H ERCC2 POLR2I POLR2J MNAT1 POLR2K TAF13 POLR3B POLR3D TAF7 TAF6 POLR3H TBP POLR3K POLR1A POLR1D HEL-S-28 TAF12 CDK7 POLR2C POLR2A POLR3E ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway SERPINB2 EGFR POLK TGFB1 EP300 MYOF BAX JUN SLC7A5 SRC UGT1A4 IL2 AHRR UGT1A7 JUND TNF CAP2 PTGES3 MGST1 NFE2L2 CDKN1B CES3 UGT1A3 NQO1 CYP1A2 CYP1B1 CDC37 UGT1A1 UGT1A9 IGFBP1 CYP1A1 IL12B HES1 IL12A JUNB AIP ALDH3A1 IFNG IL1B AHR IL17B NCOA1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 ACADS ACSL3 ACADM PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 BATF CD8B1 CD3G STAT3 CD3E CD3D CD8A JUN ZAP70 NFATC1 HLA-DRB1 NFKB1 HLA-A PDCD1LG2 IFNG NFATC3 NFATC2 PTPN11 NFATC4 LCK PDCD1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling HCLS1 CAMK2A RELA GAB2 BRAF VAV1 VAV2 FOXO1 SHC1 PDPK1 MYC CARD11 BCL10 MAPK1 PTPRC FYN MAP2K6 NFATC3 NFATC2 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 RAF1 CD79B CD79A BLNK CD19 PRKCB MAP3K7 STM7 GTF2I CR2 PIP5K1A REL PIP5K1C BLK BTK CD22 LCK GSK3B MAP4K1 MAPK9 MAPK8 CHUK BCL6 PLCG2 CRK IKBKG PLCG1 JUN NFKB1 MAX RASGRP3 CRKL INPP5D LYN SYK PIK3R2 PIK3R1 CDC42 RAPGEF1 CD81 LAT2 DAPP1 PTPN18 TIEG2 PIK3AP1 CBL RPS6KA1 NCK1 GSK3A IKBKB CREB1 MAPK4 RAC1 HRAS GRB2 SOS1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ITPR2 CYP21A2 AGTR2 PLCB2 STAR CALML6 REN CALML3 CALML4 CAMK1 CAMK2G CMA1 ATF1 ATF2 CYP11B2 AGTR1 HSD3B2 CYP11A1 CALM1 CREB3L3 CREB3L4 HSD3B1 CTSG CAMK1D CAMK1G CREB3L2 CREB3 CREB1 CREB5 CAMK2D ATF6B CAMK4 ATF4 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF RAF1 TSC2 STAT3 TSC1 NRAS EREG BTC RHEB TYK2 PTEN AKT3 KRAS SOS2 JAK1 HRAS RPTOR JAK3 MTOR GRB2 TGFA SOS1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKB1 RAF1 RRAS IKBKB CHUK MAPK1 MAP3K14 MAP2K6 TRAF6 MAP3K1 NFKBIA IKBKG SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events FOS ARC PLCD4 NLGN1 5HT1A CRHR1 PLEK PPP3CA CRH HTR2A PRKCB SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 NLRP3 TERF2IP REN TRAF3 TRAF6 SIRT6 RPS6KA1 ECSIT NDUFAF2 NFKB1 IL18 IL6 TERF2 MAVS TNF NLRX1 MITA ACE2 ACAD9 NDUFAF1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4E IFRD1 ADAM10 NR4A3 VEGFA HEL-S-52 IL18 IL1R1 IFNG CYR61 DUSP14 HBEGF JUND EIF4EBP1 GDF8 ANKRD1 MYOG ATF3 IL1A OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CCND2 TSC2 TSC1 PRLR CEBPB RAD51 CDK4 SYNE2 NR1i1 NR5A1 TBP MTOR NR3A2 NCOR1 PGR CDKN1B FSHR ATM FMR1 GJA4 LHCGR FIGLA DAZL GDF9 DMC1 CREB1 ZP3 ZP2 EGR1 SMPD1 PTGER2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG ID2 STAT3 RUNX2 SPI1 IKZF1 IRF4 IRF8 TCF4 CSF1 BATF3 CSF2 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDKN2A ACTL6B EZH2 ACTL6A CDK4 PTCH1 EED SMARCD1 CDK6 SMARCC1 SMARCA4 SMO SMARCD2 ARID1A SMARCC2 SMARCD3 SUZ12 GLI3 ARID1B RB1 H3F3B GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAP3K7 MAPK8 IKBKB CHUK RELA CD40 IKBKG EPHB2 ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CDKL5 MEF2C FRS3 CAMK2A DOK5 KCNN2 DOCK3 KCNA3 NCAM1 ARHG SIRPA SH2B1 RANBP9 MARCKS VAV2 BDNF SRC SHC1 KSR1 PDPK1 EIF4EBP1 PRKAA2 FYN SHC4 YBX1 SHC2 PTPN11 SHC3 NFATC4 NFKBIA EIF4E GRIA2 RPS6 RPS6KA5 GRIA3 RPS6KB1 SQSTM1 ACACB STAT5B PTK2B PTPRF MAPK10 MAPK9 TSC2 MAPK8 EIF2S2 STAT3 CRTC1 MAP3K2 CSNK2A1 RAP1A GRIP1 PIK3R2 PIK3R1 RASGRF1 CYFIP1 GRIN2B IKBKB RAC1 HRAS IGF2BP1 RELA STAT1 CDH2 MAP3K1 CAMK1 GRIN1 CTNNB1 CDK5R1 RPS6KA3 IRS1 MAPK1 MAPK3 MAP2K1 MAPK14 MAP2K2 ADAM17 RAF1 PRKAA1 NCF1 NTRK1 NTF3 NTRK3 PPP2CA TIAM1 EIF2S1 CDK5 GSK3B HEL-S-15 MAP2K5 NGFR EEF2 CASP3 CHUK TRAF6 PLCG1 IKBKG JUN NFKB1 MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 BAD MTOR APC CDC42 NCF2 FOXO3A GABRB3 RPS6KA1 NCK2 NCK1 VAV3 NGF CREB1 FRS2 CNR1 GRB2 SYN1 CAMK4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2L1 BCL2 FADD CASP9 CASP3 BBC3 APAF1 BAX TNFSF6 TNF MAPK12 CASP8 MAPK13 BAD MAPK11 MAPK14 MCL1 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP2C8 PTGS2 CYP2C9 CYP1A2 ALOX15 EPHX3 ALOX12B PTGS1 CYP2C19 CYP3A4 CYP4A11 GPX4 ALOXE3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 MCL1 ZAP70 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLC34A3 ITGB1 EGFR HDAC2 CFTR ANKRD35 EIF4A3 GPR89B AKAP10 SLK SUMO2 MAGOH FURIN NUDT17 HEL-S-76p HLA-B HLA-F HLA-G HLA-E RBCK1 MET SLC22A4 PEX11B CLCN3 BCL2L13 TNFRSF14 FARP2 FLT3 NHERF1 UBE2I POLR3GL CD160 PYM1 CXCR4 PDZK1IP1 POLR3C POLR3F POLR3G SIRT1 MITD1 DDIT4 LAMTOR1 IFNG LCK HFE2 HAMP STAT3 CD3D TXN CCAR2 NFKB1 HLA-A HLA-C PEX19 ZFHX3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR17 P2RY11 HTR1F ADORA2B OR2F1 F2RL2 OR2A4 GPR18 ACKR3 HRH3 ADRA1B ADRA1A PTGFR NPFFR2 RRH GPR174 PTGDR2 GPR173 GPR171 CMKLR2 CMKLR1 GPR37L1 FPRL2 TRHR TBXA2R PTGDR OR1I1 MC2R PTGIR GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 F2RL1 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW CCR8 CCR4 GPR39 OR5F1 GPR34 GPR31 NPFFR1 AVPR1A OR5V1 OPN1MW OR3A2 OPRD1 OR10H1 OR10H3 GPR45 GPR68 CCR3 OR10H2 GPR42 OR2AG1 CHML OPRK1 EDNRB P2RY10 P2RY14 NPY1R GPR52 GPR50 GPR4 GPR15 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 OR2B2 CCR6 HTR1E HTR1D HTR1B NMUR2 NMUR1 OR7A10 OR14J1 MLNR HTR2B PRLHR OR8D2 OR7A17 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 CX3CR1 OR1E2 NPY4R BDKRB2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OPN1SW ACKR4 FFAR1 ACKR2 OR11A1 KPG_010 GPR83 LPAR4 KPG_011 AVPR2 GPER CCRL2 CHRM4 CHRM5 PTGER4 PTGER2 AGTR2 CCR2 GPR75 AVPR1B NMBR CXCR4 C3AR1 PTGER1 PTGER3 GHSR RHO C5AR2 NPY2R FPR1 HTR7 BDKRB1 GPR37 MTNR1A ADRB1 MTNR1B GPR161 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 P2RY1 CHRM1 ADRA2C ADRA2B MGRA ADRA2A MC3R AGTR1 OXTR ADORA2A HTR5A 5HT1A CNR2 CCR7 CXCR5 HCRTR2 HCRTR1 MC4R CHRM2 CHRM3 OR1G1 ADRA1D GPR32 HTR2A FPR2 P2RY6 HTR4 P2RY4 GRPR HTR6 ADRB3 P2RY2 LTB4R EDNRA CCR5 OR1F1 F2R OR2H1 FFAR3 FFAR2 SSTR2 CCKBR FSHR OR3A3 OR10A5 OR3A1 OR1E1 LHCGR ADRB2 IL8RB CXCR1 CNR1 CXCR3 OR2B6 NTSR1 MC1R P2RY13 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK NFE2L2 MAPK8 SP1 MAFF MAP2K1 MAP2K2 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 PHF19 CD40 STAT4 ITGAV HLA-DRB1 MHC2TA SLC22A4 TRAF1 BLK CTLA4 IL2RA IL6ST CCR6 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 COX1 MB HBB XDH NOS2 AOX1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDKN2A EGFR SMAD4 RELA TRAF3 MAPKAP1 NRAS VEGFA IGF1R CTNNB1 PDPK1 CDK4 AKT3 ERBB2 PRKAA2 EIF4EBP1 FKBP1A KRAS RPTOR IRF6 MLST8 TP63 NOTCH2 NOTCH1 EIF4E RPS6KB2 NFE2L2 FGFR2 SESN2 PRKAA1 CSMD3 RPS6 DDIT4 SESN1 RHEB TERT NFKB2 RB1 REL STK11 CCND1 KEAP1 AJUBA TSC2 TSC1 BIRC2 PIK3CA NFKB1 MAML1 CASP8 FAT1 MTOR PIK3R2 PIK3R1 NUMB PIK3R5 CDK6 FADD FGFR1 CDKN1A PTEN RICTOR HRAS TGFBR2 FGFR3 SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism SHMT1 HEL-S-51e PHGDH TYMS SRR PSAT1 DHFR PSPH CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 RELA IFNA21 CASP10 IF1AA9 ISG15 IFNA8 CCL5 CCL4 NFKBIA IL33 NFKBIB POLR3GL IKBKE POLR3C POLR3F ZBP1 POLR3G AIM2 ATG12 POLR2L TREX1 IFNA6 POLR3A RIPK3 IFNA7 RIPK1 CHUK TBK1 IKBKG TRIM25 POLR2F RNF125 POLR2H NFKB1 CYLD ATG5 ADAR POLR2K IL6 POLR3B MAVS POLR3D CASP8 RIGI IFNA2 POLR3H POLR3K POLR1C POLR1D FADD PYCARD CCL4L2 TRADD IL18 IFNB1 IKBKB IL1B CGAS MITA NLRX1 POLR3E IFNA1 IRF3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 CHD3 HBB GATAD2B MTA2 NR2C2 HDAC1 tal-1 HBG2 LDB1 LMO2 HBD BCL11A HBG1 HBE1 GATA1 KDM1A ZFPM1 KLF1 ZBTB7A PPARGC1A MYB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA DPYS TYMP TK1 POLE4 RRM1 RRM2 UCK2 UCK1 UMPS POLR3GL POLR3C POLR3F POLR3G POLR2L TYMS ENPP1 POLR3A POLD3 POLD4 POLE RRM2B ZNRD1 HEL74 ENTPD3 NME2 NME3 CTPS2 CTPS1 POLE2 NME4 POLR2A DCTD POLE3 NME6 NME7 CMPK1 CMPK2 POLR1F UPRT DCTPP1 PRIM2 POLA2 DTYMK DHODH POLR2D NT5M POLR2J3 DUT PNPT1 POLR2J2 POLA1 CAD POLR2B ENTPD1 POLR2G POLR2H POLR2I POLR2J POLR2K POLR3B POLR3D POLR3H ENPP3 POLR3K POLR1A POLR1C POLR1D PRIM1 POLR2C POLD2 POLR3E DPYD GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG SLC5A1 PCSK1 SLC2A2 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 PTGS1 5HT1A FAAH TRPA1 PTGS2 CACNA1H TRPV1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 ETS2 BIRC5 EGF CD81 EGFR STAT3 IGF1 CD63 KDR PTEN IL6 GATA4 HEL-S-102 SPP1 HEL-S-44 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis MEF2C MIXL1 MEF2B KLF6 STAT2 CYP26A1 MEF2D NR2F1 PRLR CEBPA CEBPB EGR2 KLF5 CEBPD LIF GATA3 GATA2 CYP26B1 KLF15 SOCS3 SOCS1 TWIST1 GATA4 SLC2A4 RARA LIPE NR1C2 TRIB3 HIF1A RB1 PTGIS STAT5B GADD45B PCK2 AHR MIF HMGA1 RORA CFD RXRG WWTR1 TGFB1 STAT3 E2F4 SFRP4 DDIT3 SCD GADD45A GH1 FZD1 WNT10B PPARGC1A NCOA1 LPIN1 LPIN2 LPIN3 STAT1 ID3 FOXC2 IGF1 BMP4 FOXO1 INS FAS CTNNB1 NR1C1 IRS1 RXRA IRS4 TNF WNT5B IL6ST NCOR1 MBNL1 HNF1A BMP1 LPL NR3C1 CELF1 ZMPSTE24 LMNA CISD1 DVL1 RBL2 RBL1 WNT1 NR1H3 BMP2 OSM LEP RETN CNTFR GTF3A BSCL2 ADFP NDN BMP3 PLIN1 FRZB IL6 SPOCK1 SP1 UCP1 GDF10 KLF7 PCK1 NCOR2 NAMPT PPARG PNPLA3 CDKN1A CREB1 ASIP SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs LPAR1 MTNR1A PTGER1 PTGER3 GPR50 MTNR1B CNR2 S1PR3 PTGFR TBXA2R PTGDR PTGIR S1PR2 S1PR4 PTGER4 CNR1 S1PR1 PTGER2 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs HTR1D HTR1B HTR1F CHRM2 CHRM3 HTR2B ADRA1D HTR2A HTR4 HTR6 ADRB3 CHRM1 HTR7 ADRA2C ADRA2B ADRA2A ADRB1 ADRA1B HTR5A ADRA1A 5HT1A CHRM4 CHRM5 ADRB2 DRD1 DRD2 DRD3 DRD4 HRH1 HRH2 DRD5 HTR1E ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 AGTR2 TGFB1 REN CTSG CMA1 BDKRB2 ATP6AP2 NR3C2 MGRA BDKRB1 ACE2 CYP11B2 AGTR1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 SELE ITGB1 ITGB7 SELPLG ITGA2 MADCAM1 VCAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation GHRH BTBD9 GHRL STAR HTR2A NPY2R ADA SLC29A1 IL6 HEL-S-2 CHRNB2 UTS2R MRGPRX2 OXTR ADORA2A MTNR1B NLGN1 OXT UTS2 TH NPS NPAS2 FOS DRD1 PTGDR IL18 DRD2 DRD3 DLAT CRH CACNA1I HCRTR2 HCRTR1 PER3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway MEF2C CASP3 NCAM1 CTCF EP300 STAT3 CHD2 SMC3 HEL-S-89n NFKB1 PRNP RXRA MAPK1 FYN MAPK3 TBP HEL-S-269 RFX5 HEL-S-125m BCL2 PAX5 BATF RAD21 FGFR1 SPI1 POU2F2 IRF4 BCL11A CREB1 CASP12 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation TACI TLR4 SMCR8 IFT46 C9orf72 IFT70B WDR26 GPS1 MIEF2 RAB10 RASD1 RANBP9 RMND5A FNIP1 FNIP2 NR1H2 MYO16 MKLN1 GID4 MYO15A DRG2 RPTOR BCL2L11 MLST8 PRKAG2 PRKAB1 IRF8 HEL-S-133P G6PC1 CDC2 MYH2 WWTR1 APP PPP1R14A STAT3 BCL6 BAX YAP1 PARK2 IFT172 BLM IFT74 CLTB GRIP1 ULK1 PRDM1 IFT81 IFT27 IFT25 MED9 RAI1 GPR85 PTEN CLEC16A CARM1 RELA TNFSF13 MYC TNF FOXA1 CRY2 CRY1 PRKAA1 FOXA2 ATG101 TRAF3IP1 RAB8A FLCN IFT52 NR1H3 CFL2 PRKCI PARD3 IFT57 PER1 FLII IFT80 MYD88 RB1CC1 NT5M ARG2 TFEB BIRC2 ROCK1 JUN PARD6B NFKB1 LIMK1 MAP3K14 ARHA MTOR FERD3L HES6 PCK1 ALKBH5 CLTC MAEA DENR CLTA MIGA1 ARMC8 RNF41 TOM1L2 FHOD1 RRAGA PEMT LLGL1 DRC5 SHMT1 CLUAP1 DRC7 DRC8 COPS7A PLD6 RAB39B COPS4 IFT20 COPS6 IFT22 COPS5 DRC1 COPS8 GDI2 CREB1 WDR41 IL1B IFT56 ATPAF2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 LIPT2 LIPT1 GLDC AMT DLD HSCB LIAS GCSH NFU1 BOLA3 ISCU PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PKN2 KDR PDGFRA PDPK1 HGF PRKAA2 SOS2 MET RPTOR TGFA BCL2L11 MLST8 PDGFC FLT3 EIF4E EIF4B EGF RPS6KB2 FGFR2 GYS2 GYS1 RPS6 RPS6KB1 RHEB PIK3R3 G6PC1 JAK3 STK11 MCL1 CCND1 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 IL4 SGK1 PIK3R2 SYK PIK3R1 IL3 IL3RA GH1 MDM2 PKN3 PKN1 PTEN BRCA1 IKBKB RAC1 JAK1 HRAS IFNA13 IFNA14 EGFR NTF4 IFNA16 IFNA17 FLT3LG IFNA10 RELA IFNA21 FGFR4 IF1AA9 NRAS VEGFA FGF10 IFNA8 IL7 CSF1 IRS1 MAP2K1 MAP2K2 HEL-S-125m BCL2L1 TCL1B TCL1A PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 CDC37 TNFSF6 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 GNGT2 RBL2 FGF8A OSMR COL2A1 KIT PHLPP2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD NGFR CASP9 KITLG GHB3 CSF3 CHUK CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 CSF1R NTRK2 EFNA5 EFNA4 CHAD FGF20 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 EFNA3 PCK1 FGF14 EFNA2 PIK3R5 CDK6 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 G6PC2 ITGB4 FLT4 LAMC2 FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 IFNA1 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C TLR4 ANGPT4 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 PRL LAMB2 PPP2R3A EPOR PPP2R2C PRLR PPP2R2B PPP2R2D BDNF EIF4EBP1 GHB2 GHR CSH2 G6PC3 COL6A6 COL6A5 CDKN1B ITGB3 IGF2 ITGA2B CCND3 IFNA6 CD19 LAMC1 IBSP IL6R CCNE2 ITGA1 COL6A1 PCK2 ITGA2 COMP COL4A3 COL9A1 COL9A3 COL9A2 COL4A5 COL1A1 LAMA5 LAMB4 SGK2 THBS1 VTN SPP1 LAMB1 CCNE1 FGF23 TNC FLT1 INSR PDGFA IGF1 IGF1R INS CHRM1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 ATF2 COL1A2 MYB PDGFD BCL2 PRKAA1 PHLPP1 PPP2R2A PPP2R3B PRKCA NTRK1 NTF3 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 NFKB1 GNG13 IL6 GNB2 GNB1 IFNA2 GNB4 F2R GNB3 GNB5 GNGT1 PIK3AP1 CREB3L2 CREB3 CREB1 ATF6B HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis SYT2 HNRNPL CALM1 CAMK2A BCL2 CCND2 PRL NCAM1 RPS6KA5 RPS6KA1 NRXN1 BDNF NRXN3 NRXN2 PRKCA DRD1 NGF CAMKK1 CREB1 CAMKK2 MAPK1 PPARGC1A MAPK14 CAMK4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 RYR1 CCK RYR2 PLCB1 CCKBR DAGLA GNAI1 RYR3 CNR1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PANK2 RB1CC1 TSC2 TSC1 FTL WIPI1 WIPI2 ATG5 ATG14 CP RPTOR MTOR ULK1 PIK3R4 DEPTOR MLST8 WDR45 ACACA DCAF17 C19orf12 ATG3 COASY FA2H PRKAA1 ATG12 RHEB ATG16L1 PLA2G6 AKT1S1 ATG101 ATG2A MAP1LC3A SPTLC1 ATG10 STK11 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P REN CTSG CMA1 PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs AGTR2 TACR1 CCR2 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 CX3CR1 NPY4R BDKRB2 MC3R AGTR1 OXTR AVPR1B NMBR CXCR4 ATP8A1 TACR2 TACR3 CXCR6 TAC4 CCR7 CXCR5 FPRL2 TRHR C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 CCR10 HCRTR1 NTSR2 CCR1 GHSR MC4R BRS3 C5AR1 NPY2R CCKAR FPR2 FPR1 GRPR CCR8 CCR4 EDNRA AVPR2 AVPR1A GNRHR CCR5 OPRD1 BDKRB1 TSHR CCR3 OPRK1 EDNRB NPY1R SSTR2 CCKBR FSHR MC5R LHCGR IL8RB FY CXCR1 CXCR3 NTSR1 MC1R CCR6 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3 RNF8 NIPBL H2AX MDC1 ATM RNF168 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer GLS PYCR2 PSAT1 HEL-S-162eP PFKL PSPH ACLY ENO1 HEL-S-68p PGAM1 HEL-S-30 PAICS PDHA1 MDH2 GOT2 FASN SLC16A3 GLUD1 HEL-S-51e ALDOB TIGAR SDHB ACO2 FH RPIA SUCLG2 HEL-S-133P HK3 HEL107 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 SMAD4 CHUK RELA NR3C1 MAP3K1 MED14 IKBKG NFATC1 NFKB1 IL6 MAP2K3 IKBKB RXRA PPP3CA NR1i1 TNF MAP2K6 MAPK14 NFKBIA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA AKT3 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling MAPK8 KITLG EP300 STAT1 STAT3 GAB2 CRK PLCG1 VAV1 GRB7 SRC SHC1 SH2B2 RPS6KA3 SOCS1 MAPK1 CRKL FYN MAPK3 INPP5D BAD PTPN11 MAP2K1 MAPK14 LYN MAP2K2 TEC PIK3R2 PTPN6 PIK3R1 RAF1 FOXO3A RPS6 CBL GRB10 RPS6KA1 SOCS6 RPS6KB1 MATK PRKCB PRKCA DOK1 KIT STAT5B HRAS BTK GRB2 SOS1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2 UGT1A4 NAT2 CYP1A2 SULT1A1 UGT1A9 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo KLF4 ZFP36L2 SOX8 MXD1 ZFP42 POU5F1 GATA3 GATA2 SIX3 DPPA3 SOX2 TFAP2B IRX5 SOX11 ELAVL1 IRF4 NANOGNB FOXD1 DNMT3L KHSRP MYBL1 ZAR1 ARGFX TCF7L1 DLX2 PADI6 BARX2 LEUTX TPRX1 E2F5 TBX3 DPRX CDX2 ZSCAN4 MACROH2A2 HMGA1 HNRNPAB MTA3 FOXQ1 AQP3 NR3C2 DDIT3 PBX1 SMARCA4 AQP9 ATP1A1 NKX2-1 TEAD4 BATF3 EGR1 MOS FOSB ESRRA ZFP36 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 SCARB1 LDLR PLTP APOE LPL LIPC VLDLR APOA2 DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RPA4 MCM5 MCM6 PRIM2 POLA2 CDC45 RFC2 POLA1 RFC3 RFC4 CDK2 RPA3 RPA1 PCNA MCM2 GMNN POLD3 RFC1 PRIM1 POLD4 UBC POLE ORC6 ORC3 POLE2 ORC2 POLD2 CDC6 MCM7 ORC1L MCM10 DBF4 CDT1 MCM3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways HDAC2 CYP46A1 MBP NR1H2 BDNF EIF4EBP1 PRKAA2 RPTOR DEPTOR BCL2L11 PRKAG1 MLST8 PRKAG2 EIF4E EGF PRKAG3 C1QA RPS6KA5 PRKAB2 RPS6KB1 RHEB PRKAB1 SREBF2 AKT1S1 HMGCS1 ABCG1 PIK3R3 ABCG4 PI3 MAPK10 HAP1 MAPK9 RAB3GAP1 TSC2 MAPK8 TSC1 BAX CASP8 PIK3R4 PIK3R2 PIK3R1 AHI-1 APOE PTEN IKBKB PPARGC1A SIN3A HRAS EGFR SLC12A2 HTT AKT3 MAP2K4 MAPK1 KIF5A MAPK3 MAP2K1 MAP2K2 MAP3K10 BCL2L1 BCL2 RAF1 PRKAA1 HDAC1 NEUROD1 ABCA1 HEL-S-29 REST PIK3CD CYP51A1 CASP3 DHCR7 HMGCR PIK3CA NFKB1 IL6 NTRK2 SP1 GABRG2 BAD BNIP3 MTOR PIK3R5 PIK3C2G PIK3C2A OPA1 PIK3C2B GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 CREB1 GABRA3 GABRG3 IL1B GABRG1 RICTOR SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2 PAPSS2 PAPSS1 SULT1B1 SULT2A1 SULT1A1 SULT1E1 SULT2B1 SULT1C3 SULT6B1 SULT1C2 SULT1C4 HEL-75 SULT1A4 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity MARK1 BAK1 CASP10 MBP FAS CX3CR1 CX3CL1 MFGE8 AXL FCN1 FCN2 C1QB C1QA ITGB3 COLEC11 DIABLO PROS1 TNFSF6 C4B_2 C2 C4BPA C4A C8A HEL-S-62p C3AR1 IFNG MBL2 CR2 CR1 PRKCI PARD3 CYCS C1QC SERPING1 MASP2 MASP1 CD46 CAP1 CFD CASP9 PRKCZ CASP3 TGFB1 PATJ FCN3 APAF1 CFH BAX C4BPB C5AR2 DLGAP5 ATP11A CFI ATP11C C5AR1 SCRIB PLSCR3 PLSCR4 TYRO3 PARD6B LLGL2 PARD6A CRB2 CFP COLEC12 CRB1 PALS1 COLEC10 VTN PARD6G CLU ATP10A C6 C7 DEDD C8G CASP8 C9 ATP8B3 CD59 ATP8B2 CD55 ATP8B1 C1R ITGAM ITGAV ITGAX PLSCR1 HTRA2 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling TLR4 CAMK2A CYP21A2 STAR RELA BRAF CTNNB1 PRKAA2 MAPK1 JUND MAPK3 MAP3K5 TFAP2A MAP2K1 MAPK14 NFKBIA ERN1 BCL2 ACACA RAF1 GJA1 HSD3B1 GNAZ PRKCB GNA11 JUNB TCF4 PRKCA CACNA1H PRKCI PRKCQ GSK3B CASP9 MAPK9 CRHR1 MAPK8 CASP3 GNAI1 TGFB1 PLCG2 PLCG1 TRIM28 NFKB1 JUP IL2 SP1 CXCL8 GNB2 ARHA CRHBP GNB1 KRT1 GNAS IVL CRHR2 GNB3 GNAO1 HSD3B2 KRT14 GNB5 ECE1 CYP11A1 POMC PARP1 FOSL2 FOSL1 ARRB2 SULT2A1 FOS IL18 CREB1 CASP12 CRH FOSB SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety POMC PLCD4 ADRA1A 5HT1A PLEK EEF2K HTR2A PRKCB FMR1 FOS ARC PPP3CA CRH TRPV1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling IRAK1 IRAK2 UBE2V1 IRAK4 PRKCZ MAPK9 TAB3 MAPK8 MYD88 RELA CHUK TRAF6 MAP3K1 PLCG1 IKBKG MAP3K2 MAP3K7IP1 JUN NFKB1 MAP2K3 HEL-S-71 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 PIK3R2 PIK3R1 IRAK3 NFKBIB PELI1 HSPB2-C11orf52 ECSIT MAP3K7 SQSTM1 IL1R1 IKBKB IL1B REL MAPKAPK2 IL1A PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYS DHODH TYMP NT5C3A RRM1 RRM2 TYMS CAD ABAT UMPS OTC RRM2B GLS2 HEL74 DPYD OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL1 FADS1 ELOVL5 SCD5 ELOVL6 FASN ELOVL3 FADS2 SCD ACSL1 ELOVL2 FACL4 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 CS PC SDHA HEL-S-26 OGDH ACLY FH DLD SUCLG2 DLAT HEL-S-32 HEL60 PCK1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36B IL36RN STAT1 IL36G IL1F10 GATA3 SOCS3 CSF1 SOCS1 MAPK1 BCL2L11 IL37 POLR2L ANAPC1 ZNRD1 IL1R1 IL23A POLR1F ARF6 PLCG2 POLR2F POLR2H IL2 POLR2K IL6 POLR1A POLR1C POLR1D CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 TTL IL1RL2 NT5DC4 IL1B CSF2 RAC1 IL1RN MERTK CXCL13 GRB2 IL36A IL1A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling EGFR FLT1 RELA INSR FGFR4 BRAF PML CSNK1A1 FOXO1 IGF1R SRC KDR KSR1 SHC1 PDGFRA GAREM2 CTNNB1 MYC AKT3 MAPK1 SOS2 KRAS MET MAPK3 RPTOR MAP2K1 NFKBIA DEPTOR MAP2K2 MLST8 FLT3 ZBTB16 PYGO1 RAF1 BCL9 RARA FGFR2 RUNX1T1 LEF1 EPHA2 RHEB AKT1S1 NR1C2 IL6R NTRK1 TCF3 KIT WNT1 REL CCND1 GSK3B PIK3CD NGFR TSC2 RETN CHUK TSC1 STAT3 IKBKG AXIN2 JUN PIK3CA NFKB1 JUP CSF1R NTRK2 IL6 LRP5 LRP6 ULK2 MTOR APC TTI1 SALL4 FGFR1 FLT4 MDM2 FOS CDKN1A PTEN IKBKB HRAS GRB2 NFKBIE SOS1 FGFR3 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma CDKN2A PAK1 BAK1 NRAS BRAF KDR CDK4 AKT3 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC2 PTPN11 MAP2K1 PDE5A MAP2K2 RAF1 HEL114 E2F2 DDB2 PIK3R3 RB1 KIT GADD45B GADD45G CCND1 PIK3CD POLK CALML6 ARAF EXOC7 BAX CALML3 CALML4 PIK3CA ARHA BAD GADD45A PIK3R2 PIK3R1 CALM1 CDK6 E2F3 RHOB NF1 MDM2 GRM3 PREX2 CDKN1A PTEN RAC1 HRAS GRB2 SOS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia RELA NRAS BRAF PML CEBPA MYC AKT3 EIF4EBP1 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 FLT3 ZBTB16 RAF1 RPS6KB2 RARA RUNX1T1 RUNX1 SPI1 LEF1 MPO RPS6KB1 NR1C2 CCNA2 PIK3R3 TCF7L2 TCF7L1 KIT STAT5B PER2 CCND1 PIK3CD CHUK STAT3 ARAF IKBKG PIK3CA NFKB1 JUP CSF1R BCL2A1 BAD MTOR PIK3R2 PIK3R1 IL3 PIM1 PIM2 ITGAM CEBPE FCGR1A IKBKB CSF2 HRAS GRB2 SOS1 CD14 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TEDC1 TEDC2 IFT46 FBF1 KATNB1 IFT70B TUBD1 KIF3B CEP76 MIB1 TUBE1 KIAA0753 CPLANE2 SASS6 CEP162 OFD1 CIBAR1 CEP44 CEP20 DYNC2I2 CEP19 DYNC2H1 DYNLT1 DYNLT2B TRAF3IP1 DYNC2LI1 IFT52 KIF3A TMEM107 BBS9 BBS7 IFT57 RABL2B BBS5 BBS4 IFT140 DNCL1 IFT80 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 IFT172 TMEM216 WDPCP IFT74 CEP104 CEP192 ARL6 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 SCLT1 IFT81 FUZ TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP97 IFT27 CC2D2A CLUAP1 ARMC9 IFT25 RPGRIP1L PIBF1 IFT20 CPLANE1 TMEM231 TMEM17 TTC23 C2CD3 B9D1 CBY1 IFT56 RAB23 EFCAB7 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 CCDC41 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis GSK3B ATP7B SLC31A1 ATP7A APP CASP3 COX17 MT2A SLC31A2 FOXO1 COX11 JUN COMMD1 MT4 MT3 PIK3CA ATOX1 MT1A MTF1 PRNP MT1F SP1 MT1G MT1B XAF1 STEAP1 STEAP2 MT1E HEL-S-44 CCS APC STEAP4 ADAM17 ADAM10 FOXO3A MDM2 STEAP3 PTEN ADAM9 CCND1 SLC11A2 BACE1 SCO1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence HMGA1 SLC2A4 MDH2 PARP1 GOT2 ELAVL1 NAMPT CCL27 PRKAA1 RELA SIRT1 SIRT3 IL6 IL1B SIRT5 HEL-S-32 NMNAT2 SIRT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 HBA2 HBE1 GATA1 HBB HBZ tal-1 HBG2 LDB1 LMO2 HBD RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MCM6 TTK CDC45 RRM1 RRM2 TOP2A DHFR WEE1 SUV39H1 HMGB1 CDK4 MYC CDK2 MAPK13 RPA3 SMC2 RPA1 NPAT HLTF PLK4 CCDC6 RAF1 CDKN1B RBBP7 HDAC1 CCND3 TYMS E2F2 PRMT2 POLD3 SMC1A CCNA2 CCNE2 POLE TFDP1 CCNB2 RB1 CCNB1 RBBP4 POLE2 CDC2 CCND1 CDT1 CHEK1 FAF1 CDC25B POLA1 SMC3 MSH6 RFC3 RFC4 BARD1 FANCG SAP30 HMGB2 PCNA PRKDC TFDP2 CDK6 E2F3 MDM2 CCNE1 H2AZ1 RBP1 ZNF655 SKP2 PRIM1 CDKN1A SIN3A MCM7 ORC1L MCM3 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA MMACHC MMADHC TCN2 MTR CD320 TCN1 CUBN CBLIF OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy COL1A1 COL3A1 RELA STAT3 RUNX2 FGFR4 RELB CTGF CEBPB ACAN VEGFA JUN PIK3CA KDR COL10A1 NFKB1 AKT3 MAPK1 JUND SPP1 MAPK3 VHL SOX9 FOSL2 FOSL1 FGFR2 FGFR1 CNMD P4HTM GANC DDR2 IBSP JUNB FOS NTRK1 PRKCA LAMTOR1 HIF1A NGF COL2A1 FOSB FGF23 FGFR3 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 ST3GAL5 ST3GAL1 NEU3 B4GALNT1 NEU4 HEXB HEXA ST8SIA1 ST8SIA6 SIAT4C B3GALT4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 FOXL2 BNC1 NR5A1 WT1 AMH DCAF17 ATG9A CYP17A1 NBN LAMC1 ZAR1 ALOX12 STAG3 SLX4 BLM FANCM FANCL WRN FANCA FANCC HSD17B4 HSD17B1 RFWD3 NUP107 ERAL1 PRDM1 SALL4 ATM BMPR1A FMR1 BMPR2 BRCA2 POLR2C PCCA PCCB STAR BMP6 RAD51 NR3A2 TP63 NOTCH2 AMHR2 LMNA PRORP ANTXR1 EIF2B1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 EIF2B2 PREPL MSH4 NOBOX KHDRBS1 AARS2 EIF2B5 AIRE PPM1B HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 TGFBR3 HROB LHX8 MCMDC2 MCM9 ELAVL2 BMP15 POLG LARS2 C1orf146 MRPS22 SIX6OS1 HAX1 PSMC3IP RECQL4 CCDC185 MGME1 C10orf2 MND1 GNAS CENPE POLR3H NLRP11 XPNPEP2 SPATA33 MST1R FSHR FIGLA DAZL CLPP GDF9 DMC1 ZP3 PGRMC1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 PLCB1 RPP38 PRKCB SPHK1 SGMS2 PRKCA CDK4 CDKN1A SGPP1 TERT RB1 UGCG CDK2 MAPK1 S1PR2 SPTLC1 GLB1 S1PR5 S1PR1 DEGS1 MTOR KDSR MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 H2AX CDKN1A MYC CDKN1B CREB1 CCND3 CCNE1 ATM RAD52 CCND1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3C8 EZH2 SET SUV39H2 SUV39H1 SETD2 EHMT1 H3C15 EED KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L EZH1 KMT2C SETD7 PRDM2 KMT2A SMYD2 KMT5B SMYD4 SMYD3 H4C7 H4C9 MLL2 SETDB1 HIST1H4L KMT5C SMYD1 SETD1B SETD1A SETDB2 SETMAR AEBP2 H3F3B ASH1L SETBP1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DICER1 DROSHA RAN TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer MMP9 CDKN2A EGFR TYMP ARAF NRAS BRAF VEGFA SRC THBS1 RASSF1 CDK4 MYC CXCL8 ERBB2 HBEGF MAPK1 KRAS MAP2K1 MAP2K2 PIK3R2 PIK3R1 EGF RAF1 RPS6KA5 MDM2 CDKN1A RB1 MMP2 DAPK2 HRAS UPK3A CCND1 FGFR3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN HIF1A VEGFA VEGFB VEGFC HES1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX14 COA6 COX1 CSRP2BP PET100 FAM36A COX10 CMC1 TMEM177 PNKD COX17 SMIM20 COX7A2 COX11 COX7B COX4I1 SURF1 COA3 COX6A1 COX8A COX2 COX6B1 COX7C COX3 COXFA4 COX5A COX19 COX16 COX18 TACO1 HIGD1A PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway HEL70 RDX ARHA SEPTIN2 MYL2 RAB35 KIF23 EZR OCRL EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects RGS16 PRL KLF2 CXCL12 ERBB4 MYB 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MEF2C PRL ASCL1 SEPTIN2 MROH2A DGKD HJURP ERFE KLHL30 THAP4 RRAGB ACKR3 RRAGD AGAP1 RAMP1 OR6B3 TRPM8 OR6B2 GAL3ST2 MTERF4 RAB27A COPS9 GBX2 SNED1 NFKBIA RTP5 RNPEPL1 PRH MYOG ING5 FARP2 SEPT6 HEL-S-28 KIF1A ILKAP AQP12B AQP12A AGXT DUSP28 CXCR4 GABARAPL2 ANO7 OTOS RPS6 ITGB3 GYS1 ARL4C USP40 ARF5 ASB18 CENPA CYTH2 SPP2 D2HGDH IRF8 ANKMY1 CYTH1 MLPH CAPN10 RAB17 ASB1 ARF1 HAMP CXCL12 TWIST2 UBE2F CALCRL UGT1A3 RAC1 NEU4 CXCL11 SH3BP4 UGT1A8 EGFR TRAF3 PDX1 PDGFA TNF DISC1 UGT1A10 BOK UGT1A1 UGT1A9 ABCA1 HES1 MAP1LC3A TRAF3IP1 MAP1LC3C EEF1A1 PER2 MYOD1 CALCA DKFZp762B153 DTYMK MAP4 JUN UGT1A4 GABARAPL1 UGT1A7 GABARAP SEPTIN4 HES6 GPC1 PDCD1 CALM1 RRAGA IL13RA1 COPS8 IL1B NEDD8 NDUFA10 PPP1R7 ITPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 ZEB2 HDAC2 ELF3 TGFB1 SUZ12 FOXC2 HDAC1 SIRT1 EZH2 SNAI1 SNAI2 SUV39H1 TCF4 KDM1A PRRX1 TWIST1 KLF8 GSC2 SIX1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway CPT2 KLK15 CYP8B1 PLTP FABP1 ACADM SLC27A1 EHHADH UGT1A9 DBI NR1C1 CDK4 MYC APOA5 RXRA NR1H3 APOC3 CPT1A CYP4A11 CDC2 CYP7A1 CCND1 APOA2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 CYP2A6 UGT1A10 CYP1A2 SULT2A1 CYP1B1 SULT1A1 SULT1E1 CYP1A1 CYP2E1 UGT1A4 UGT2B15 CYP2C19 CYP3A4 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2C8 CYP2J2 COX5A CYP2C9 HEL-S-22 COX8A EPHX2 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 HEL-S-68p H2AX H3F3B STAT3 KHK HEL-S-30 MYL2 SNAP23 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GTPBP4 GJB6 ITGB1 CCND2 LAMA5 NCAM1 INHBA RUNX2 PDGFA SNAI1 BMP4 SHH EDAR NFKB1 PDGFRA CTNNB1 MYC LRP5 PTCH1 TP63 SMO FGFR2 FZD1 LEF1 TNLG7C CCND1 FOXI3 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis IL3RA TF GDF11 HBB KITLG EPOR EPO TNFSF6 CD79A HBG2 HBD HBG1 HBA2 HBE1 GATA1 FAS GATA2 CD34 PTPRC KIT TFRC HBZ IL3 ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MMP9 CREBBP ANGPT1 FGFR2 FLT1 FGF2 VEGFA PLCG1 SRC PIK3CA KDR PDGFRA HIF1A MAPK1 SMAD1 MAPK14 TIMP3 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 MAPK10 MAPK9 MAPK8 CRP ACLY SLC27A2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 G6PC3 PRKAG1 PRKAG2 ACACA PRKAG3 PRKAA1 G6PC2 PRKAB2 PRKAB1 ACACB G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC CUL4A ERCC5 POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 GTF2H5 CUL4B ERCC2 MNAT1 RBX1 RPA3 RPA1 ERCC1 PCNA CETN2 CDK7 POLD3 RFC1 POLD4 DDB2 POLE LIG1 POLE2 POLD2 POLE3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL5 ACSL3 CD36 FABP1 FABP9 FABP4 FABP5 DBI FABP6 SLC27A4 ACSL1 FABP2 ACSL6 FACL4 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL10 TMPRSS2 IL2 IL6 IL7 CXCL8 IL1B TNF ACE2 CCL2 IL2RA CCL3 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects GSK3B IRAK1 CAMK2A CSNK1D MAP2 ASMT SULT1A1 TRAF6 FOXO1 NFKB1 CSNK1E CYP2C19 ACHE MAOA ECE1 CALM1 ADRB1 MTNR1A CRY2 MTNR1B CRY1 APOE CYP1A2 CYP1B1 SIRT1 CYP1A1 AANAT EDN1 PRKCA PER2 PER1 PER3 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB4 MMP9 PIK3CD PLCB1 PLCB2 STAR NRAS KISS1R KISS1 BMP15 PIK3CA NFKB1 MAPK1 KRAS MAPK3 AMH MAP2K1 MAP2K2 CYP11A1 RAF1 ARRB2 FSHR HSD3B1 PRKCH PRKCB PRKCE PRKCA GDF9 PLCB3 HRAS PRKCQ THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis ADCY3 ADCY1 ADCY8 ADCY6 RPS6KA2 NRAS KDM3A HEL-S-7a KDM1A RPS6KA3 PRKG1 MAP2K3 PRKAA2 SOS2 MAPK12 KRAS MAPK13 MAP3K5 ATF2 RPTOR MAPK11 MAPK14 PRKAG1 MLST8 PRKAG2 SMARCD1 SMARCC1 ACTG1 CREB3L3 SMARCD2 RPS6KB2 PRKAG3 CREB3L4 SMARCC2 PRKAA1 SMARCD3 RPS6KA6 RPS6 LIPE PRKACG ARID1B PRKAB2 RPS6KB1 RHEB CPT1C PRKAB1 AKT1S1 ADCY9 ACSL1 ACSL6 FACL4 CPT2 ACSL5 ACSL3 TSC2 TSC1 ACTL6B SIRT6 SLC25A29 ADRB3 BMP8A BMP8B ACTL6A ZNF516 PLIN1 MGLL KDM3B UCP1 PRDM16 CPT1A GNAS FGF21 MTOR PNPLA2 SLC25A20 GCG SMARCA4 ARID1A PPARG FGFR1 PS1TP5BP1 RPS6KA1 CREB3L2 CREB3 CREB1 FRS2 PPARGC1A CREB5 CNR1 DPF1 HRAS DPF3 GRB2 SMARCE1 SOS1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy LPIN1 LPIN2 LPIN3 ITGB4 BSCL2 CAVIN1 INS PIK3CA HMFN0839 DGAT1 HIF1A IRS1 FYN GRB2 DGAT2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation RORA KLF4 CEBPA CEBPB TLE3 EGR2 FOXO1 KLF5 CEBPD INS GATA3 GATA2 EVI1 KLF15 KLF2 DDIT3 NR2F2 CTNNA1 ZNF423 RARA PPARG WNT10B NR3C1 IRF4 TCF7L1 CREB1 NR1H3 STAT5B IRF3 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PLCB4 MYL3 ADCY3 ADCY1 PLCB1 ADCY8 PLCB2 ADCY6 MYL1 NR3C1 ADRB2 MYL4 PLCB3 CREB1 ADCY9 PRKAR1B PRKAR1A MYL2 GNAS STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 STAR HSD3B1 CYP17A1 HSD17B1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COL1A1 MBTPS1 PPIB PLOD2 MIA3 LRP5 TMEM38B COLGALT1 MBTPS2 IFITM5 LRP6 CRTAP P3H2 P3H1 COL1A2 PLOD1 ADAMTS2 LOX P4HA1 BMP1 TNFSF11 FZD1 SP7 TNFRSF11B P4HA2 TNFRSF11A WNT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS5 CERS1 CERS2 tmp_locus_29 B4GALNT1 B4GALT1 CERS3 CERS6 CERK SGMS1 SPHK1 B3GNT5 SGMS2 A3GALT2 DGAT1 UGT8 UGCG SPTLC1 A4GALT KDSR MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B FGFR2 AXIN1 MAP3K1 ROCK1 FRAT1 CTNNB1 FOXL2 MAPK1 ARHA WNT4 SRY MAPK11 GADD45G FGF9 SOX9 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling NOD2 IL2RG TGFB1 HLA-DMA IL10 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL4 IL5 IFNG TNF MAF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IF2B1 TLR4 RORC STAT1 STAT3 STAT4 IL12RB1 IL12B TYK2 IFNG IL23A IL17F CSF2 TNF STAT5B IL17A ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA2 MAPKAP1 SHC1 PDPK1 CYP3A4 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 RPTOR SHC3 PRKAG1 MLST8 PRKAG2 SLC2A4 EIF4E RPS6KB2 PRKAG3 CBLC RPS6KA4 RPS6KA6 GYS1 RPS6KA5 PRKAB2 MAP3K8 RPS6KB1 MAP3K6 RHEB MAP3K7 PRKAB1 SREBF2 PIK3R3 G6PC1 MAP3K12 HEL-S-31 FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 EXOC7 MAP4K3 MAP3K2 HEL-S-42 ABCG8 ABCG5 SCD CYP7A1 PIK3R4 SESN3 PIK3R2 PIK3R1 TRIP10 RAPGEF1 MAP3K13 GSK3A HRAS INSR MAP3K1 FOXO1 INS RPS6KA3 IRS1 MAP2K3 RXRA IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 MLXIPL FASN PRKAA1 LPL CYP2B6 ANGPTL8 NR1H3 THRA GSK3B PIK3CD MAP2K5 SLC16A2 CRK SLCO1C1 PIK3CA MAPK7 NR1A2 MAP3K14 MTOR PCK1 FOXO3A PIK3C2G PIK3C2A FBP1 CBL RPS6KA1 MAPK6 MAPK4 RICTOR SOS1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape MCM5 MCM6 CAMK2A IFT46 CREBBP IFT70B HDAC2 WDR26 RANBP9 RMND5A RAB14 XPNPEP3 MKLN1 GID4 CTBP2 DYNC2I2 NEFL TFAP2B DYNLT1 DYNLT3 DYNLL2 NDUFA5 DYNLT2B RB1 MCM10 MYL6 DYNC1H1 DYNLRB2 EXOSC4 DNCL1 EXOC8 TBC1D4 EXOC7 YAP1 EXOC4 EXOC3 EXOC6 IFT172 MSH2 EXOC5 EXOC2 DOCK5 EXOC1 IFT74 PSMD7 TFAP2C SNAP29 DGKE UBE2D2 MCM2 SMC4 APMAP IFT81 TIPRL ERF ARL8B INTU USH1C CEP97 DDX5 HEL-S-296 IFT27 CDH23 NUP88 IFT25 AAR2 PSMD12 CTSA UBE2H TFAP2D HEL-S-91n TFAP2E PSMD13 RHBDD2 EXOC6B CNOT10 GDI1 LSM4 EHD3 CNOT1 WNK1 LCN2 RANBP10 RAC1 UQCC GLB1 ZMYND19 MYL6B RPGR TMED1 GLA DFNB31 NINL RBM14 PSMC6 NUDC ECHS1 PSMC4 CNOT6L NUP133 EIPR1 RAB3IL1 HEL113 ARFGAP3 RABEP2 CD2BP2 NME8 MAPRE2 CEP170 CCDC40 IFT70A ANKS3 VPS4A RAB21 RQCD1 RMND5B WEE1 DNPEP PGRMC2 VAPB BBIP1 GID8 CTNNB1 NEF3 YPEL5 DCAF7 TFAP2A HDAC1 MFAP1 PAFAH1B1 POM121 EIF5B TRAF3IP1 DVL3 RAB8A IFT52 BBS9 BBS7 IFT57 SNRPB2 BBS5 CEP290 IQGAP3 ACSL3 BBS4 IQCB1 IFT140 IFT80 LZTFL1 IFT43 MCM9 HEL-S-47e CBS NFKB1 EFHC2 STOM DYNC1LI1 APC BBS2 NEK8 BBS1 CALM1 MAEA ARMC8 FUZ TTC8 IQGAP1 MKS1 CLUAP1 COPS7A COPS4 IFT20 COPS6 IFT22 SSNA1 COPS5 COPS8 RALB CDR2 H3F3B NDUFA9 HTRA2 IFT56 MCM7 LRPPRC MCM3 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis OXCT1 ACAT1 HMGCL BDH1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members GSK3B PIK3CD TSC2 TSC1 MAPKAP1 IKBKG FOXO1 PIK3CA PARP3 AKT3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 MLST8 PARP2 PIK3R5 PARP1 PHLPP1 PIK3C2G PIK3C2A SIRT1 PIK3C2B ATM PIK3R3 RICTOR STK11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC2 TSC1 PRR5 MAPKAP1 HMGCR RRAGB RRAGD DDIT4L PRKAA2 EIF4EBP1 FKBP1A RPTOR ULK2 MTOR ULK1 PRKAG1 MLST8 PRKAG2 CDC42 PRKAG3 PRKAA1 RRAGA DDIT4 PRKAB2 RPS6KB1 IDI1 RHEB PRKAB1 AKT1S1 PRKCA RAC1 RICTOR EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host TLR4 ITGB1 IRF7 CREBBP EP300 CAV3 NEDD4 VAV2 SOCS3 HLA-B HLA-F HLA-G HLA-E HLA-DRA FLNA VPS11 VPS39 VPS16 AXL IKBKE VPS18 CLEC4M VPS33A ITGB3 ICAM2 RFC1 VPS41 PIK3R3 C1QBP MBL2 ITGA1 ITGA2 SCIN ITGA4 HLA-DRB5 HLA-DMA RAB7A TYRO3 HAVCR2 HLA-A IL4 CLTB CTSL HLA-C ACTN1 ACTN4 PIK3R2 PIK3R1 EIF2AK2 RAC1 MERTK IRF3 HLA-DQA2 HLA-DQA1 EGFR PAK1 RELA STAT1 VPS4A IGF1R HLA-DRB1 MFGE8 CLEC10A ICAM3 MAPK1 HLA-DOA HLA-DOB MAPK3 KPNA1 BST2 CD300A TFAP2A TIMD4 TSG101 CLEC6A RAB5A ASGR1 CD209 HAVCR1 ADAM17 HLA-DPA1 HLA-DQB2 RAB9A HLA-DQB1 ACTG1 HLA-DMB DAB2IP HLA-DPB1 FOLR1 NFKB2 NPC1 REL TIAM1 EIF2S1 RASA2 PIK3CD RELB TBK1 PIK3CA NFKB1 CAV2 ARHA RIGI CLTC CDC42 FLNB CLTA PRKRA IQGAP1 RHOB PS1TP5BP1 ITGAV CLTCL1 ITGA6 NPC2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAPK8 STAT3 MYEF2 JUN PRKCB EDN1 PRKCE FOS MAP2K3 GATA4 PPP3CA MAPK1 ARHA RAC1 CTF1 CAMK2D MAPK11 MAPK14 NFATC4 IL6ST FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 CPT2 ACSL5 ACSL3 ACAT1 ACADM DLD HEL-S-49 CPT1A ACADVL LIPC ACADL PNPLA2 SLC25A20 ACADS CHKB HADHB LPL GCDH LIPF LIPE CRAT ACSS2 GPD2 DECR1 ACSL1 ACSL6 FACL4 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling MEF2C MEF2B ITGB1 CDKN2A KLF4 MEF2D SRC LAMTOR3 SHC1 EIF4EBP1 HDAC7 FYN PTPN11 NFKBIA RHOD ELAVL1 CDKN1B RPS6 RPS6KB1 PXN TCF4 PIK3R3 CCND1 CD44 MAPK9 MAPK8 STAT3 KAT5 IL2 CXCL8 PIK3R2 PIK3R1 MMP7 TJP1 IKBKB RAC1 EGR1 HRAS SERPINB2 BIRC5 EGFR PAK1 PTGS2 RELA SLC9A3 VEGFA FOXO1 CTNNB1 CLDN1 MYC IRS1 MAPK1 KRAS MAPK3 ATF2 MAP2K1 MAPK14 MAP3K11 BCL2L1 RAF1 ARHGEF28 GAS PRKCH TFF2 PRKCE PRKCA KIT PRKD2 PRKCQ PRKD1 BMP2 GSK3B CASP3 CHUK CRK PLCG1 BIRC2 ROCK1 BIRC3 JUN PIK3CA NFKB1 SP1 ARHA HDC BAD MTOR CDC42 ANXA2 YES1 CCKBR ARRB2 PPARG FOXO3A RHOB FOS CDKN1A CREB1 GRB2 SOS1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 DNAJB1 CRTC2 CREB1 SIK1 HDAC7 GNAS SIK3 SIK2 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 CD68 LYZ CD163 F3 CD14 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer GSK3B RB1CC1 TSC2 MAPKAP1 TFEB NRAS FOXO1 PIK3CA EIF4EBP1 KRAS BAD RPTOR MTOR ULK1 PIK3R2 PIK3R1 MLST8 CDKN1B FOXO4 FOXO3A GRB10 RHEB PIK3R3 PTEN RICTOR HRAS GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CCK VIP SCT PGA3 PGC PGA5 MUC6 GAS CBLIF MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3CD PLCG2 NCKAP1L VAV1 VAV2 TREM2 PIK3CA TREM1 LAT LYN PIK3R2 SYK PTPN6 PIK3R1 CYBB ITGAM NCF2 C1QB C1QA PIK3C2A RAC3 NCF1 NCF4 FCER1G VAV3 PIK3R3 FCGR1A CYBA RAC1 ARPC1B SIGLEC7 TYROBP C1QC MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 STK11 CTDSP1 STRADB GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P PFKP HEL-S-30 PPM2C 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 TRAF2 ATG16L1 ATG101 GABARAPL1 GABARAP RB1 TNF PTK2B MAP3K5 ULK1 WDR45B TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NR1D1 SMAD2 STAT1 TGFBR1 ZAP70 TYK2 GATA3 IL27 SOCS3 RXRA MAPK1 LAT MAPK14 NFKBIA CRY1 RARA RUNX1 IRF4 NFIL3 IL6R IFNG HIF1A IL23A IL17F AHR PRKCQ LCK PER1 IL17A IL27RA IL2RA IF2B1 IL23R RORC RORA MAPK8 CD3G IL-21 TGFB1 CD3E HLA-DMA STAT3 CD3D TBX21 IL21R PLCG1 IFNGR1 JUN NFATC1 FOXP3 NFKB1 IL2 IL4 IL6 MTOR FOS IKBKB PPP3CA IL1B JAK1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RBP3 RDH11 RDH8 RHO RBP1 RDH5 OPN1LW RLBP1 RPE65 RDH10 OPN1MW RDH12 OPN1SW LRAT ABCA4 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCB4 PI4K2B PIK3CD PLCD3 TPTE2 PLCB1 PLCD4 IPMK PLCB2 FIG4 PI4KB PIP4K2A PLCG2 PLCG1 PIK3CA INPP5D PI4K2A INPP5E PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR8 INPP4A STM7 INPP4B PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SACM1L OCRL PIKFYVE MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 FST FGFR2 RBFOX2 CBX2 SOX8 EMX2 AMHR2 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 INSL3 WT1 WNT4 SRY MAPK11 RSPO1 AMH FGF9 SOX9 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 FIS1 MIB1 OPA1 BAX MTFP1 MFN2 BNIP3 MFN1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 PFKM HEL-S-68p PGAM2 HEL-S-133P GPT HEL-S-49 HEL-S-30 HEL-S-87p HEL-S-162eP FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 ORAI1 KL DMP1 CYP24A1 FGFR2 ALPL FAM20C SLC34A1 ROS1 GALNT3 PTH ENPP1 NFKB1 CDKN1A NFKB2 CYP27B1 SPP1 CCND1 CYP11B2 FGF23 FGFR3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling ADCY3 ADCY1 ADCY8 ADCY6 STAT2 GNG3 GNG2 GNG5 CCR2 GNG4 GNG7 VAV1 GNG8 VAV2 CCL11 SHC1 c-fgr CX3CL1 CCL5 CCL19 CCL7 SOS2 CCL28 SHC4 SHC2 CCL4 SHC3 NFKBIA CCL1 NFKBIB CCL15 CXCR4 CXCR6 PRKACG PXN PIK3R3 STAT5B PTK2B CCR10 JAK3 CCR1 XCR1 GNAI1 CXCL12 STAT3 WAS CCR8 GNAI3 CCR4 RAP1A CRKL CCR3 LYN PIK3R2 PIK3R1 IKBKB RAC1 HRAS CXCL13 CXCL11 CXCL14 CCR6 PLCB4 PLCB1 PLCB2 PAK1 RELA STAT1 BRAF NRAS ADRBK1 PPBP CX3CR1 CXCL3 AKT3 MAPK1 KRAS XCL1 MAPK3 MAP2K1 CCL17 CCL20 CCL25 CCL24 CCL22 RAF1 CCL21 CCL27 PF4 CCL26 NCF1 PRKCB GNG10 CCR7 CXCR5 GNGT2 ADCY9 TIAM1 PARD3 GSK3B PIK3CD PRKCZ GRK5 CHUK GRK4 WASL PREX1 CRK ELMO1 IKBKG ROCK1 GRK1 ROCK2 DOCK2 GNG12 PRKX GNG11 PIK3CA NFKB1 GNG13 GNB2 GNB1 ITK GNB4 CXCL5 GNB3 GNB5 CDC42 PIK3R5 ARRB2 FOXO3A GNGT1 CXCL16 VAV3 IL8RB PLCB3 CXCL9 CXCR3 CSK GRB2 SOS1 CCL3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 CYFIP1 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP9 EGFR SMAD2 COL1A1 SMAD4 FLT1 RELA TGFBR3 RELB CHD2 CTGF SNAI1 VEGFA SNAI2 TGFBR1 NRP1 SRC KDR NFKB1 PLXNA2 HGF AKT3 PLXNA1 PLXNA4 CDK2 MAPK1 MAPK3 MET COL1A2 MAP2K1 MAP2K2 SEMA3A EGF CDKN1B CCNE1 GSK3A CCNE2 PECAM1 NFKB2 MMP2 RAC1 REL TGFBR2 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CDKN2A DOCK1 HGF EIF4EBP1 RPTOR PTPN11 CDKN1B HSD3B1 HSD17B3 ETV4 HSD17B7 CYP17A1 RHEB PXN RB1 PTK2B CDC2 CCND1 CHEK2 CHEK1 MAP4K1 TSC2 MAPK8 TSC1 STAT3 BAX CDC25B MSH6 MSH2 BLM ACTL6A CPN1 RAP1A KLK3 BARD1 CASP8 CRKL HSD17B4 HSD17B1 HSD3B2 PLK1 RAPGEF1 SMARCA4 ARID1A F13B NOXA1 MDM2 ATM ATR PTEN BRCA1 JAK1 HRAS ERG SMAD2 PAK1 STAT1 MRE11A RAD50 CDK4 MYC CDK2 MAPK1 MAPK3 ATF1 MAP2K1 MAPK14 MAP2K2 FOXA1 BCL2 SMARCD1 SMARCC1 RAF1 SMARCD2 SMARCC2 SMARCD3 ARID1B FKBP5 HSD17B2 CDKN2B SPRY2 CASP9 CASP3 ACTL6B CRK EIF4E1B JUN PIK3CA SP1 SPRY1 SPINK1 BAD MTOR PRKDC FOS CDKN1A RICTOR GRB2 SOS1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR FASN PRKAA1 SIRT1 HMGCR ABCA1 SIRT6 SREBF2 HMGCS1 NR1C1 NR1H3 PPARGC1A MED15 SCD MTOR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK1 IRAK2 MAPK8 MYD88 TGFB1 RELA CHUK TRAF6 MAP3K1 MAP3K7IP1 JUN NFKB1 IL6 MAP2K3 TNF MAP3K14 MAP2K6 MAPK14 NFKBIA IRAK3 ECSIT MAP3K7 IFNB1 IL1R1 IKBKB IL1B IL1RN IFNA1 IL1A FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR3 S1PR4 S1PR5 HEL-S-171mP MS4A1 S1PR1 BTK EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3 NR1D2 G0S2 PSMA4 KLF9 HLA-DMA HEL-S-22 CEBPB PPP1R3C DAZAP2 BTG1 TOB1 STBD1 CLDN5 SUMO3 ERC2 RBPMS CRY2 ZFR ETV6 AAG1 CRY1 HEL-S-72p MYF6 SUMO1 UCP3 IDI1 NCKAP1 GSTM3 PIGF PURA QK3 PER2 H2BC15 PER1 VAPA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 IKBKE IFNB1 MAVS TRAF3 RIGI TRAF6 TBK1 IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CDH17 SCEL PLA2G10 SPRR1B TSPAN8 FAM83A CYP3A7 DHRS9 TNS4 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 KRT20 LGALS4 VSIG2 S100A2 AGR2 AGR3 TFF2 CST6 FAM3D REG4 KRT6C SERPINB3 BTNL8 KRT7 GPR87 ANXA10 LYZ LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 AREG KRT6A FGFBP1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IRAK1 NLRP3 MMP9 PLA2G7 MYD88 HEL-S-134P TLR1 PIK3CA FCER1A NFKB1 F2 S100A9 IL18 IL1R1 IFNG HBEGF IL1B CCL2 F2R CCR3 TIMP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R2 PPP4R4 PARP4 HEL-S-69 ASPHD1 TCP1 KCTD13 ZG16 INO80E MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 MAP2K3 MAPK3 MAP2K6 TBX6 CCDC6 PPP2R1A PAXIP1 KMT2C NR3C1 PAGR1 SMEK1 REL PPP2CA EZR SPN PRRT2 PPP4R3B TRAF2 TRAF6 NFKB1 CASP8 BPTF HEL-S-87p PCNA CCT7 TAOK2 PPARG MLL2 HEL70 PPP2R5D PTEN UNC13B UNC13A HEL-S-90n CCT6B HDAC3 SIAH1 DOC2A FAM57B FIMP CDIPT PPP4R1 CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-29 HEL-S-20 NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B YES1 NFE2L2 MAPK8 INSR NQO1 CEBPB EPHB2 SRC PIK3CA SLC7A11 HMOX1 PRKCA RBX1 PGAM5 FYN MAF GCLM AIMP2 KEAP1 GCLC CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways CAMK2A ADCY3 CDKN2A ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CAMK2G PDGFRA HGF SOS2 MET TGFA BCL2L11 EGF RPS6KB2 TPM3 FGFR2 NR1C2 PIK3R3 SUFU HIF1A PTCH2 KIF7 STAT5B IL2RG CXCL12 CALML6 ARAF CALML3 FZD10 STAT4 CALML4 IL12RB1 FRAT1 FRAT2 IFNGR1 IL13 EVI1 IL2 IL4 IL5 CXCL8 IL5RA KLK3 CSF2RB CRKL PIK3R2 PIK3R1 IL3 IL3RA EDNRB MGST1 FADD GSTT2 FZD1 WNT10B WNT10A NQO1 FZD3 TXNRD2 FZD2 FZD5 FZD7 FZD9 FZD8 GNA13 IKBKB HRAS APC2 PLCB4 IFNA13 IFNA14 PLCB1 IFNA16 PLCB2 IFNA17 IFNA10 PTGS2 RELA IFNA21 FGFR4 IF1AA9 NRAS BMP4 SHH WNT7B WNT7A FAS CTNNB1 IFNA8 IL7 BDKRB2 MAP2K1 MAP2K2 WNT5B GSTM2 RAF1 TNFSF6 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A RET CYCS GSK3B WNT2B PIK3CD CASP9 CASP3 CHUK APAF1 AXIN1 TRAF2 TRAF6 CRK ROCK1 ROCK2 AXIN2 WNT16 PIK3CA LRP5 ARHA LRP6 NOS2 BAD MTOR APC CDK6 JAG2 E2F3 FZD4 PPARG FGFR1 GLI3 HEY2 CBL WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 PTGER4 IFNA1 GRB2 PTGER2 SOS1 GSTT2B FGFR3 CCND2 TFG EML4 NKX3-1 PLEKHG5 IL15RA ARHGEF11 CDKN1B BBC3 SPI1 IGF2 CCND3 IL12B DDB2 IL12A IL6R CCNE2 IFNG IL23A PMAIP1 GADD45B GADD45G ARHGEF12 PTGER1 PTGER3 GNAI1 BAX PTCH1 SMO SMAD2 SMAD4 RXRA BCL2 NFE2L2 HDAC1 GNA11 NTRK1 ARNT2 EGLN1 EGLN3 RASGRP4 EGLN2 CDKN2B ELOC HMOX1 EDNRA F2R RALBP1 CTBP1 PLD2 SKP2 ARHGEF1 RALB APPL1 CREBBP HDAC2 EP300 CEBPA CTBP2 FLT3 ZBTB16 RARA RUNX1T1 PRKACG RPS6KB1 CCNA2 RB1 JAK3 CCND1 IL2RA IL2RB IL15 MSH6 MSH2 MAX RASGRP3 TPR VHL GADD45A F2RL3 MDM2 MGST3 MGST2 GSTM3 PTEN BRCA2 GSTM5 MMP2 RAC1 MMP3 JAK1 TGFBR2 NCOA1 RALA EGFR FLT3LG BAK1 STAT1 PML DCC MSH3 VEGFA RAD51 HEL-S-125m BCL2L1 GSTA5 GSTA4 KPG_010 RUNX1 GSTA3 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 F2 GNGT2 NFKB2 KIT VEGFB VEGFC HHIP VEGFD POLK KITLG HEL-S-22 CSF3R EPO IFNAR2 BIRC2 COL4A2 BIRC3 COL4A1 COL4A4 COL4A6 IFNAR1 CSF1R TXNRD3 IL7R HSP90AB1 FLT4 LAMC2 ITGAV CDKN1A ITGA6 LAMA1 LAMA4 LAMA3 ITGB1 LAMB3 LAMB2 STAT2 EPOR ALK ERBB2 NFKBIA CTNNA1 CTNNA3 CTNNA2 CXCR4 RPS6KA5 ITGA2B RAC3 E2F2 IFNA6 IFNGR2 LAMC1 FH CKS1B ITGA2 TRAF1 TRAF4 COL4A3 TRAF5 RARB COL4A5 BIRC7 MAPK10 RXRB RXRG LAMA5 MAPK9 MAPK8 LAMB4 TGFB1 STAT3 CCDC42 GNAI3 JUP CASP8 BDKRB1 LAMB1 KNG1 CCNE1 EDN1 BIRC5 CSF2RA TRAF3 PDGFA GSTM1 BRAF IGF1 TGFBR1 FOXO1 IGF1R RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 NR3A2 AGTR1 IL6ST NOTCH2 NOTCH3 CCDC6 NOTCH1 LEF1 PRKCB HES1 HES5 PRKCA TCF7L2 TERT TCF7L1 ADCY9 GSTM4 BMP2 KEAP1 LPAR1 PLCG2 PLCG1 IKBKG JUN SKP1 PAX8 GNG12 GNG11 NFKB1 GNG13 RBX1 IL6 SP1 GNB2 GNB1 IFNA2 GNAS GNB4 BCR GNB3 GNB5 PIM1 PIM2 GNGT1 HEL-S-21 FOS IL13RA1 PLCB3 DAPK2 CAMK2D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 LEP LPIN1 MAPK8 PPARG INSR NR3C1 CEBPA CEBPB FOXO1 CEBPD IL6 IRS1 RXRA CREB1 TWIST1 PPARGC1A TNF PCK2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 CREB3L3 CREB3L4 RELA RELB IL10 CREB3L2 NFKB1 CREB3 NFKB2 IL6 CREB1 IL1B MAPK12 REL CREB5 MAPK13 CCL2 MAPK11 MAPK14 CD14 ATF4 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CDC45 MRE11A PML FOXM1 SMARCAL1 RAD50 RAD51 CDK2 DCLRE1A RPA1 UBE2D3 HUS1 FANCD2 HERC2 TOPBP1 CLK2 RECQL EEF1E1 CLSPN TDP1 H2AX SMARCC2 FEN1 NBN SMC1A RNF8 CEP164 ATRIP SHFM1 CDC2 RAD52 CHEK2 RAD17 RAD1 CHEK1 RAD9A XPA PPM1D RBBP8 BCL6 MDC1 IKBKG TRIM28 MSH2 BRIP1 TP53BP1 MCPH1 RECQL4 WRN SP1 FANCA BARD1 UIMC1 PALB2 RFWD3 PLK1 PCNA PRKDC MCM2 PARP1 ABRAXAS1 BRCC3 MDM2 ATM ATR BRCA1 POLN BRCA2 RMI1 USP1 TOP3A XRCC5 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 ACADS ACSL3 SLC22A5 ACADM HADHB PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 SRD5A2 CYP21A2 AKR1D1 AKR1C1 HSD3B1 CYP17A1 HSD3B2 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma CDKN2A EZH2 KIF23 KDR PDGFRA HGF CTBP2 PRKAA2 MET RPTOR CCL4 TGFA DEPTOR PRKAG1 MLST8 PDGFC PRKAG2 FLT3 EIF4B EGF WIF1 RPS6KB2 PRKAG3 FGFR2 RPS6 PRKAB2 RPS6KB1 RHEB PRKAB1 AKT1S1 HIF1A LIMD1 MCL1 CCND1 TNNT1 ITGA4 NF2 TSC2 TSC1 CXCL12 YAP1 FABP4 FZD10 ROR2 FRAT1 FRAT2 IL10 CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E MAX DKK1 DKK2 DKK4 SFRP4 DDIT3 BARD1 CSNK2B STK38L TNIK ULK2 ULK1 FOSL1 FZD1 CDK7 WNT10B WNT10A FZD3 MDM2 ATM FZD2 FZD5 FZD7 FZD9 UHRF1 FZD8 PTEN BRCA1 LATS1 TEAD4 MMP2 LATS2 MMP3 JAK1 HRAS TEAD2 TEAD3 MMP14 PLCB4 EGFR NTF4 FLT3LG PAK1 BAK1 STAT1 FGFR4 MAP3K1 VEGFA CSNK1A1 WNT7B SFRP1 SLC7A5 WNT7A CTNNB1 FGF10 HMGB1 RPS6KA3 CSF1 HBEGF MAP2K3 MAP2K4 CHD8 MAP2K6 MAP3K5 MAP2K1 MAPK14 MAP2K2 MAP3K10 WNT5B MAP3K11 RAF1 KMT2C EPHA2 AGER ASXL1 WDR5 BAP1 DVL1 FGF8A DVL2 DVL3 KIT WNT1 WNT3 WNT4 RBBP4 FGF6B WNT3A VEGFB MAPKAPK2 CYCS VEGFC MCU VEGFD GSK3B WNT2B PIK3CD WWC1 MAP2K5 NGFR SOX17 KITLG RB1CC1 CER1 CSF3 AXIN1 TRAF2 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA MAPK7 CSF1R NTRK2 LRP5 EFNA5 EFNA4 LRP6 FGF20 FGF22 FGF7 FGF21 CXCL5 FGF8 EFNA1 MTOR FGF9 APC EFNA3 FGF14 CSNK1A1L EFNA2 FGF13 FGF18 FGF12 FGFR1 ITGB4 FLT4 LAMC2 AMOT FGF2 FGF7B ITGAV FGF7A RASSF7 CDKN1A NGF ITGA6 FGF5C LAMA1 LAMA4 LAMA3 GRB2 CXCL1 AREG SOS1 FGFR3 NLRP3 ANGPT4 IDO1 MMP9 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 LAMB2 MEF2D BDNF SRC SHC1 SETD2 CCL5 EIF4EBP1 CCL2 MOB1A CTNNA1 CTNNA3 CTNNA2 RASSF2 RASSF3 RASSF4 BBC3 RASSF6 ITGB3 RPS6KA5 HCFC1 IGF2 PHC1 CCND3 PRSS23 IL34 MAD2L1 MAP3K6 DSC3 LAMC1 BAG2 MDK RNF2 CTHRC1 MOBKL1A ITGA1 PAK6 CDH9 CDH8 PAK4 CDH4 ITGA2 CDH10 COL4A3 CDH11 CDH12 HEL-S-31 CDH15 AJUBA COL4A5 CDH17 VGLL4 ACTA2 CIT CD44 MAPK10 CDH19 MAP4K1 CDH24 LAMA5 MAPK9 WWTR1 MAP4K2 MAPK8 SPARC MINK1 TGFB1 LIN28B BAX MAP4K3 CTGF MAP3K2 EED LAMB1 SELE TTI1 MDM4 LGALS9 SUZ12 HMGN1 CCNE1 PPARGC1A CSF2 BMI1 FGF23 FLT1 PRB1 INSR PRB2 CDH6 PDGFA CDH2 IGF1 CD47 OGT FOXM1 CDH16 FOXO1 IGF1R INS RASSF1 CDK4 MYC AKT3 CDK2 YY1 MAPK1 RYK MAPK3 ROR1 ATF2 PDGFD BCL2 ACTG1 EIF4G1 PRKAA1 SOST LEF1 NTRK1 TCF7L2 TERT NTF3 TCF7L1 PIGF KREMEN1 SENP2 SFRP5 ATF3 CXXC4 PORCN NOTUM SLC3A2 BTRC JUN NFKB1 IL6 SP1 SETD5 CTBP1 PS1TP5BP1 HEL-S-1 RPS6KA1 BTC GABPA SETDB1 CDH18 MAD1L1 ACTA1 CREB1 IL1B ACTG2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling TLR4 IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 TRAF3 LY96 IFNA21 IF1AA9 TIRAP MAP3K7IP1 IFNA8 AKT3 MAP2K3 CCL5 MAP2K4 MAPK1 TNF MAPK12 MAPK3 MAP2K6 MAPK13 CCL4 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B IFNA7 MAP3K7 RIPK1 IL12A TICAM1 IRAK1 IRAK4 MAPK10 MAPK9 TAB3 MAPK8 MYD88 CHUK LBP TRAF6 TBK1 IFNAR2 IKBKG JUN IFNAR1 NFKB1 IL6 TLR5 CXCL8 CASP8 SPP1 IFNA2 TLR9 TLR7 FADD FOS IFNB1 IKBKB IL1B RAC1 CXCL9 IFNA1 CXCL11 IRF3 TLR8 CD14 TLR3 CCL3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2 EPHX2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway KIR2DL1 KIR2DL3 VAV1 PLCG1 PRKCA LCP2 IFNG CD34 CSF2 HLA-C TNF RAC1 FYN HRAS LAT TYROBP PRKCQ GRB2 SYK PTPN6 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX H2AB1 H3C8 SUZ12 BCL6 H2AZ1 EZH2 H2AZ2 RNF2 H3C15 H2AB3 PCGF1 H3F3B MAPK1 H2AJ MAPK3 EED MACROH2A1 BCOR MACROH2A2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH COQ6 COQ2 SLC52A1 PDSS1 ETFA COQ8A FLAD1 COQ9 APTX COQ7 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMB3 LAMA5 LAMB2 SRC SHC1 IRS1 EIF4EBP1 MAPK1 ARHA MAPK3 PTPN11 MAPK14 MTOR PIK3R2 PIK3R1 LAMB1 ITGB4 LAMC2 LAMC1 PRKCA ITGA6 RAC1 LAMA1 HRAS LAMA3 GRB2 SOS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HEL-68 HCLS1 TLR4 KRT18 TUBA2 ITGB1 ARPC2 ARPC3 TUBA8 LY96 WASL ROCK1 WAS ROCK2 TUBB8 TUBA1C CTNNB1 CLDN1 TUBB6 TUBA1B TLR5 TUBA1A ARHA FYN TUBB1 ARHGEF2 CDC42 TUBB ACTG1 TUBA4A YWHAQ TUBB2A PS1TP5BP1 NCL NCK2 TUBAL3 NCK1 YWHAZ PRKCA TUBA3E ARPC5 ARPC1B TUBB4B EZR CD14 TUBB4A ARPC4 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 MTARC2 MOCS1 XDH GPHN AOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds GSK3B FZD1 MBOAT1 DKK3 LEF1 AXIN1 CSNK1A1 FZD7 FZD8 TCF4 CTNNB1 DVL2 SFRP4 WNT1 TNKS APC CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells RGS16 CAMK2A ADCY3 ADCY1 CACNB1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G RGS10 CASQ1 RGS11 FKBP1A GJB1 ADRA1B ADRA1A GNAZ GJB6 GNAI1 GJA9 ATP1B3 STIM2 GJC1 GJB4 GJB3 GNAI3 ANXA6 GJD2 HEL-S-99n CASQ2 ATP1A4 PLN KCNJ3 KCNB1 CXNA GNAO1 ADRB1 ATP1B2 ATP1B1 CAMK1 FXYD2 CHRM1 ATP2B3 ATP2B2 ATP2B1 HEL2 GJB2 ORAI1 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 CACNA1C RGS6 RGS7 PRKCH PRKCB GNA11 PRKCE PRKCA CACNB3 CACNA1S ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ CHRM2 CHRM3 GRK5 GRK4 ADRA1D SFN ADRB3 GNG12 GJA3 GNG11 GJA5 GNG13 GJA8 PKIB CXNO PKIA GNB2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 CACNA1B RYR1 RYR2 ATP2A2 CACNA1A ARRB2 RYR3 GNGT1 KCNJ5 YWHAQ HEL-S-1 YWHAG CHRM4 CHRM5 GJA4 YWHAZ ADRB2 PLCB3 RGS18 RGS17 CAMK2D RGS14 CAMK4 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling EGFR CREBBP AGTR2 CSF2RA F2RL2 MAPKAP1 IL10RA SRC TYK2 PDGFRA SOCS3 MAPK1 PTPRC IL11RA MAPK12 MAPK3 MAPK13 CTF1 RPTOR GHR IL15RA MAPK11 MAPK14 DEPTOR AGTR1 IL6ST MLST8 IL10RB IFNGR2 PRKCB IFNLR1 AKT1S1 IL6R OSMR JAK3 IL20RA IL20RB IL27RA IL2RA IL2RB MAPK10 MAPK9 IL2RG MAPK8 STAT3 CSF3R IFNAR2 IL21R CNTFR TRIM28 IFNGR1 IFNAR1 MAPK7 PTPRT IL5RA MPL CSF2RB MAPK15 IL22RA1 F2R MTOR IL9R IL3RA IL7R SETD7 F2RL3 DUSP2 MAPK6 MAPK4 JAK1 RICTOR DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism DDC NQO1 MAOA PRKACG PPP2CA TH HEL-S-44 TYR HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC5 CD44 CASP9 SMAD4 MAPK8 PTGS2 CASP3 TGFB1 STAT3 MYOF RRM2 VEGFA COL4A2 TGFBR1 VAV2 BIRC3 JUN NFKB1 FRZB MYC IL6 CXCL8 MAPK3 NOS2 PTPN11 MAPK14 BCL2L1 HNF1A LEF1 TNFSF6 E2F2 HEL-117 IL6R CDKN1A BRCA1 HIF1A CXCR1 RAC1 JAK1 GRB2 CCND1 SOS1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders ECHS1 ACAT1 PSAT1 PSPH ENO1 HEL-S-68p GLDC AMT HEL-S-30 PHGDH HEL-S-20 SLC2A4 ETHE1 SQOR SUOX SPCS1 CDO1 GCDH HEL-S-51e LDHB MPC1 HEL-S-133P GPT HK3 DHTKD1 G6PC1 HEL-S-32 GCK SLC25A15 ASL MOCS2 MOCS1 SFXN1 GPHN ARG1 HEL-S-162eP CBS PFKL SLC25A1 ENO2 PFKM ENO3 SLC25A5 MPC2 PGAM2 ALDH7A1 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-87p CTH MOCS3 HK2 AASS SLC7A2 HEL60 PCK1 PDHA1 MDH2 GOT2 PKLR ASS1 XDH GLUD1 ALDOB SHMT1 FBP1 PC SLC2A3 BTD HLCS SLC2A2 OTC GLS2 AADAT DLAT MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes AP3D1 ARHG ARCN1 WDR11 CEBPB PPIB LAMTOR3 PLXND1 TUSC2 ARID4B HEL-S-30 VPS39 FADS1 TNLG5A TPM3 GYS1 RAB34 MAP3K8 ANAPC1 TMED10 RAB5C ADIPOR2 SLC1A4 CORO1C SAC3D1 MCL1 MPDU1 CD164 SNAP23 BRPF3 HMGA1 CAP1 TBCA IGF2R BCL6 MENT SLC25A1 ADPGK THBS1 TNFAIP2 ADAR LMNB2 TUBA1A TMEM109 ACP2 PRSS21 SCYL1 TXN2 RFT1 DDX5 UNC93B1 GNA13 DNAJB1 POLR2C SPTLC1 ATP6V1F CDIPT ATP6V0E1 POLE4 FMNL2 SERPINE2 CTNNB1 DCAF7 PNP CHORDC1 MAPK14 GOLGA7 CDK5RAP3 BCL2 PPIF IFRD1 LPL PISD MTHFD2 TYMS RTN4 POM121 MRPL20 SLC7A11 RDH10 KCNN4 SNX6 PHC2 SFXN1 HEL-S-26 HEL-S-47e ARF4 TRAM1 HMOX1 MRC2 TMEM43 TMED3 SH3BGRL3 CTSC CDK6 ANXA2 ATP2A2 PRPF40A YWHAQ SLC7A6 CDCP1 FRG1 PTRH1 NELFCD HEL-S-66 PTPA USP1 CA12 SHOC2 SRSF10 APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis BIRC5 IRF7 CDKN2A BAK1 RELA TRAF3 CASP10 MAP3K1 IGF1 IGF1R FAS LTA MYC MAP2K4 TNF NFKBIA IRF6 BCL2L11 TP63 NFKBIB BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO IGF2 TNFSF6 CASP6 IRF4 RIPK1 IRF1 PMAIP1 TRAF1 TNFRSF10B MCL1 CYCS MAPK10 BNIP3L CASP9 CASP3 TP73 CHUK APAF1 BAX TRAF2 HRK IKBKG BIRC2 PRF1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 TNFRSF25 CASP8 CRADD BAD SCAF11 PIK3R1 BCL2L2 IRF2 FADD HELLS MDM2 TNFRSF21 TRADD IKBKB TNFRSF1B IRF3 NFKBIE OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F8 CYP2C8 CYP2J2 CYP4F11 CYP46A1 CYP26A1 CYP2S1 CYP27C1 CYB5R3 CYP7B1 CYP26B1 CYP4V2 CYP27B1 CYP2C19 CYP3A7 CYP3A4 CYP2W1 CYP11B2 CYP27A1 CYP2R1 CYP3A43 CYP2A7 CYP8B1 CYP26C1 CYP2C9 CYP2A6 CYP2B6 CYP17A1 CYP2A13 CYP4A22 CYP2F1 CYP4B1 CYP20A1 CYP4F2 CYP4A11 CYP4F12 POR CYP51A1 CYP24A1 CYP7A1 CYB5R1 CYP11A1 CYB5R4 CYB5B CYP1A2 CYP1B1 CYP1A1 CYP4Z1 CYP2E1 CYP2U1 CYP4F22 CYP4X1 CYP2C18 CYP4F3 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CREBBP EP300 FGFR4 CEBPA SETD2 MYC ERBB2 KDM6B ARID4B MYB MAP2K2 NCOR1 NFIB ARID5B NOTCH1 RAF1 KMT2C TLK1 SMC1A MYBL1 CHEK2 CHEK1 PIK3CA BCORL1 MAX FGF16 PRKDC FBXW7 MAML3 SRCAP JMJD1C CTBP1 HIST1H1E ARID1A CMTR2 MAGI1 DTX4 FOXO3A HIST1H2AK INSRR FOXP2 MORF4L1 ATM KAT6A MYCBP MGA KANSL1 UHRF1 PTEN BRCA1 HRAS BCOR SMARCE1 ERBIN MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MYLK PLCB2 RCAN1 CISH MYEF2 IGF1 MAP3K7IP1 IGF1R LIF CTNNB1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 GATA4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 CTF1 MAP2K1 MAPK14 NFATC4 MAP2K2 CDK9 IL6ST EGF RAF1 IKBKE FGFR2 PRKCB DVL1 PIK3R3 WNT3A EIF2B5 GSK3B PIK3CD NPPB MAP2K5 MAPK8 TGFB1 CHUK STAT3 IKBKG ROCK1 ROCK2 PIK3CA MAPK7 NFKB1 LRP5 LRP6 ARHA MAP3K14 MTOR PIK3R2 PIK3R1 CALM1 FZD1 CDK7 FZD2 FGF2 NPPA EDN1 IKBKB PPP3CA MAPK4 RAC1 CAMK2D MYLK3 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 SLC19A3 DKFZp667O1614 HEL107 SLC19A2 OGDH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IFI6 STAT2 STAT1 IFNGR1 ISG15 SOCS3 SOCS1 HLA-B MHC2TA NOS2 IFNA2 PTPN11 TAP1 CYBB IRF2 OAS1 SPI1 IRF9 IFIT2 H4C9 IFNGR2 IRF4 EIF2AK2 IRF8 IRF1 GBP1 IFNB1 IFNG IL1B JAK1 CXCL9 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 ITGB1 CDKN2A EGFR HEL113 IGF2R STAT1 BAX IGF1 CLDN7 JUN IGF1R SRC NFKB1 CTNNB1 CLDN1 CDK4 CDK2 TLN1 PIK3R1 NOTCH1 BCL2 CDKN1B PSEN2 ABCC1 IGF2 CCNE1 MDK PRKCA PECAM1 PTEN TACSTD2 RB1 ACVRL1 RAC1 PAK4 CCND1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 LPAR1 JAG2 ALPL PLAT CALU SOX6 VEGFA GJA5 DLL3 DLL4 ITGA1 MGP FGFR3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT1 ACAT2 HMGCR GGPS1 IDI1 FDPS MVK HMGCS1 FDFT1 IDI2 PMVK MVD HMGCL FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP STAT1 SNAI1 BMP4 ATG5 MAPK1 MAPK12 IHH MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 FGF9 MAP2K2 SOX9 RAF1 FGF18 PTHLH RBL1 CDKN1A NPR2 PTH1R PPP2CA BMP2 THRA FGFR3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades TFPI C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PAK1 ZAP70 GRAP2 LCP2 CDK4 CARD11 BCL10 PTPRC TNF FYN MAPK3 NFATC2 LAT MAP2K1 NFKBIA CTLA4 MAP2K2 PTPN6 RAF1 MAP3K8 MAP3K7 CD40LG IFNG PRKCQ LCK GSK3B DAG1 MAPK9 CHUK CD3D CD8A IKBKG PLCG1 IL10 JUN PIK3CA NFKB1 IL2 IL4 IL5 RRAS MAP3K14 ITK PDCD1 ICOS CALM1 CBL NCK1 FOS IKBKB CHP1 CSF2 AHSA1 GRB2 SOS1 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP SMAD9 BMP7 ZNF423 PPARGC1B PPARG DGIC ZIC1 CEBPA CEBPB BMP4 CEBPG DKFZp781O1323 SLC7A10 PRDM16 PPARGC1A HSPB7 SMAD1 CIDEA EBF3 BMP2 HOXC9 HOXC8 MPZL2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer CDKN2A EGFR BAK1 NRAS BRAF ALK RASSF1 PDPK1 CDK4 HGF AKT3 RXRA ERBB2 MAPK1 EML4 SOS2 KRAS KIF5A MET MAPK3 HEL-S-61 MAP2K1 STK4 MAP2K2 TGFA EGF RAF1 E2F2 PRKCB DDB2 PRKCA RB1 STAT5B GADD45B JAK3 GADD45G CCND1 RET CYCS RARB PIK3CD FHIT POLK RXRB CASP9 RXRG CASP3 STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA CASP8 BAD GADD45A CDK6 E2F3 CRABP2 CRABP1 FOXO3A CDKN1A HRAS GRB2 SOS1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 RPH3A MLPH UNC13D MADD TBC1D10A SYTL2 EXPH5 RAB27A RAB27B SYTL1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MCM5 MCM6 CDKN2A CCND2 CDC45 WEE1 CDK4 MYC CDK2 RPA3 RPA1 CREB3L3 CDKN1B CREB3L4 CCND3 E2F2 CCNE2 POLE TFDP1 CDKN2D RB1 CCNB1 CDKN2B POLE2 CCNG2 CDKN2C CDC2 CCND1 PRIM2 POLA2 MYT1 CCNH CDKN1C MNAT1 GADD45A PCNA TFDP2 MCM2 CDK6 E2F3 CDK7 MDM2 CCNE1 ATM PRIM1 CREB3 CDKN1A CREB1 ORC6 ORC3 ORC2 MCM7 ORC1L MCM3 ATF6B DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 HDAC2 LAG3 STAT2 EP300 STAT1 CXCL2 TRAF3 AP1G1 NUP98 RAE1 PPBP CXCL6 IFITM1 CXCL3 CCL5 TP53I3 TNF ACE2 CCL2 CCL4 TFAP2A LARP1 MX1 CD160 PF4 IFIT2 RIPK1 IL6R hEMMPRIN TRAF5 TANK TGFB1 CXCL12 TRAF2 TRAF6 TBK1 IFNAR2 DHX58 TRIM25 IL10 HAVCR2 IFNAR1 NFKB1 IL6 CXCL8 MAVS CASP8 RIGI CXCL5 TLR7 FADD TRADD IL8RB IFNB1 CSF2 JAK1 CXCL9 CXCL17 CXCL13 CXCL11 CXCL1 IRF3 CCL3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP9 CASP3 BBC3 APAF1 TP53AIP1 BAX MDM2 ATM EI24 SHISA5 CYS1 ZMAT3 PERP DDB2 PTEN PMAIP1 SIAH1 CASP8 TNFRSF10B SESN3 CHEK2 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP LRP5 LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ECHS1 TDO2 IDO1 ACAT1 STAT1 ASMT TPH2 TPH1 AOC1 ALDH8A1 IL4I1 DLD DDC MAOA AOX1 ALDH2 GOT2 GCDH CYP1A1 KYAT3 KYAT1 AANAT INMT AADAT HAAO AHR KMO KYNU AFMID IDO2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 MAPK8 PTGS2 TSC1 PINK1 IKBKG FOXO1 PIK3CA HMOX1 NFKB1 GSX1 IPCEF1 IL6 PIP CXCL8 MAP2K3 CDK2 MAP2K4 TNF NOS2 MAP3K5 ATF2 MAPK14 MTOR BCL2L1 BCL2 NFE2L2 NQO1 RPS6KA5 SIRT1 MDM2 CCNE1 RHEB ATR NRF1 FOS CDKN1A PTEN IKBKB CREB1 KEAP1 IL1A UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP9 CAMK2A EGFR SMAD2 CREBBP EP300 RELA CTNNB1 HDAC5 TRPC4 CDK2 MAPK1 TNF MAPK3 PTPN11 MAPK14 AGTR1 CYBB BCL2 NCF1 NCF4 ABCA1 AIFM2 CYBA COL2A1 CDC2 VCAM1 GSK3B ACTA2 NPPB COL1A1 CASP9 MAPK9 COL3A1 MAPK8 CASP3 TGFB1 CHUK ALOX5 STAT3 BAX ESPL1 HMOX1 NFKB1 PLN IL6 UTS2R DDIT3 ARHA PCNA NCF2 UTS2 CCNE1 NPPA GSK3A NOX4 PTEN IKBKB MMP2 IL1B HSPA2 IRF3 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL5 ACSL3 STAR FABP4 LPA DBI SLC27A2 SORT1 APOC2 SLC27A3 SOAT1 APOC1 LIPA PCSK9 APOA4 SCARB1 APOB LDLR MYLIP FABP1 APOE SLC27A1 ABCA1 SOAT2 SLC27A4 ACSL1 STARD3 FABP2 ACSL6 NPC2 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis BMP7 TCF21 SIX2 WNT9B RSPO3 FOXD1 OSR1 ALDH1A2 GREB1L PAX2 MEIS1 FGF20 WNT4 WNT3A RSPO1 FGF8 NOTCH2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 CCL13 IL10RA ACKR3 CCL8 CCL7 CCL4 CCL1 CCL18 TNFRSF14 CCL15 TNLG5A LEPR ACVRL1 CCR10 CCR1 XCR1 IL2RA IL2RB IF2B1 IL23R IL15 GDF11 TNFRSF10A CD27 IL2RG IL-21 CXCL12 IL18RAP IL21R IL12RB1 IL10 CCR8 IFNGR1 EDAR CCR4 IL13 BMP8B IL2 IL4 IL5 CXCL8 IL5RA CSF2RB CCR3 IL3 IL3RA GH1 IL9 BMPR1A BMPR2 TNLG7C TNFRSF19 LTB IL1RN CXCL17 CXCL13 IF2D TGFBR2 CXCL14 IF2G IL36A CCR6 IL1A IL36B INHBA GDF5 IL36RN IL36G PPBP INHBB IFNW1 BMP4 IL1F10 CXCL6 IL24 FAS IF1IB1 IL27 CX3CR1 CXCL3 IL7 PF4V1 CSF1 IL19 XCL2 TNF IFNK XCL1 IFNL2 IFNL3 CCL20 ACKR4 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 TNFSF6 TWEAK TNFRSF12A IL1R1 ACVR2A IL27RA NGFR CSF3 CSF3R EPO IFNAR2 CNTFR TNFRSF1A IFNAR1 BMP3 CSF1R GDF10 CXCL5 GDF3 TPO IL7R NODAL TNFRSF21 IFNB1 NGF IL1R2 CXCL9 CXCL1 ACVR1B CCL3 TACI PRL CNTF EPOR CXCL2 CCR2 PRLR CCL23 CCL11 LIF LTA CX3CL1 CCL19 CCL5 CCL28 CCL2 IL15RA GHB2 IL18R1 GHR AMH CXCR4 CD40 IL25 CXCR6 IL34 IL10RB IFNGR2 IFNLR1 BMP10 TNLG7A IL6R CD40LG IFNG IL23A IL17F IL17D IL17C TNFRSF10B IL17B IL20RA IL20RB IL17A TGFB1 TNFRSF4 TNFRSF9 MPL ACVR1 IL22RA1 IL9R ACVR2B TNFSF11 GDF15 TNFRSF11A IL1RL2 TNLG2B CSF2 CXCL11 CSF2RA IL17RC IL17RB BMP6 IL17RA TGFBR1 IL11 IL11RA gdf7 TNFSF14 GDF1 GDF6 RELT IL6ST CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 BMP7 INHBC BMP5 TNFSF10 INHBE TNFRSF18 ACVR1C LTBR TNFRSF11B AMHR2 CCR7 IL1RL1 CXCR5 GDF8 LEP ANP32B BMP15 TNLG1B IL6 TNFRSF25 CCR5 IFNA2 TNFRSF13C TNFRSF10C TSLP CXCL16 CCL4L2 IL13RA1 IL8RB GDF9 IL18 TNFRSF1B CXCR1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNAI1 GNG2 KCNK9 CHRNA5 TH CHRNA6 KCNK3 PPP1R1B SLC18A2 DDC DRD2 DRD3 CHRNB2 CHRNA3 DRD4 GNB1 CDK5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA4 ITGB1 HLA-DMA CD63 CD151 SHH HBEGF LGALS3BP HLA-DRA CHST6 EXT1 CRY2 ALKBH3 HLA-DMB CHST1 LEF1 GLI3 CD82 MAPK8IP1 IGSF8 NRXN1 CD19 SPPL2C B4GALT4 PRDM11 ACCS PHF21A C11orf96 ALX4 TP53I11 LARGE2 EXT2 PEX16 IZUMO1 ITGA6 SDCBP SLC35C1 SYT13 VANGL1 MS4A1 FREY1 REST SLC25A17 B4GAT1 TIMP1 B3GNT7 PEX3 TSPAN18 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 TGFB1 CCR2 IL12RB1 IFNGR1 IFNGR2 IL12B CCR7 CCR4 IL12A IL2 IL4 IL5 CD40LG IFNG CCR5 CSF2 CXCR3 CCL4 IL18R1 CCR3 CCR1 CCL3 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA2 PDHA1 CHKA ACHE PEMT ChAT MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 SOCS3 MYC STAT3 CHI3L1 BAX IL6ST AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG2 CSN1S1 EIF4E EIF4G1 TSC2 EEF2 PRKAG3 PRKAA1 CSN3 EEF2K PRKAB2 RPS6KB1 PRKAB1 CSN2 PRKAA2 RPTOR MTOR EIF4A2 PRKAG1 MLST8 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 NFKB2 APOE RELA SPI1 TRAF6 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway EDN2 TSC22D3 PTGS2 SNAI2 POU5F1 B3GNT5 CDC42EP3 ACKR3 TNFAIP3 PMP2 ANGPTL4 MFGE8 IL11 RXRA NR1I3 FGD4 GPR153 CCL2 SERTAD2 CCL20 CAVIN2 PTGES3 NR1i2 KTN1 RGS2 NR3C1 DNER SCNN1A NFKB2 SLC26A2 ABHD2 DNAJC15 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 PPP1R14C ALOX5AP NAV3 ADGRF4 BIRC2 CDKN1C BIRC3 JUN PRRG4 STOM S100P SPRY1 THBD TNS4 PDE4B BHLHB2 SLC19A2 PLK2 AMIGO2 CPEB4 EPB41L4B ENC1 ANKRD1 FGFBP1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NDUFB10 MEF2D RELA VAV1 SH2B3 ZAP70 GRAP2 TNFAIP3 PDPK1 LCP2 CARD11 BCL10 SOCS1 LAT NFKBIA PTPN6 CDKN1B CUL5 MAP3K8 DGKZ SH2D1A REL PRKCQ LCK RASA2 DGKA TMEM222 MAP4K1 ARIH2 CD3G UBASH3A CD3E CHUK RPRD1B CD3D FIBP CD8A CD5 TRAF6 AGO1 IKBKG PLCG1 NFKB1 ARHH MAP3K14 ITK PIK3R2 PIK3R1 RNF7 GNA13 IKBKB GRB2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling IBSP PDGFRA COL1A1 TNFSF11 ITGB3 BGLAP PTH1R PTH TNFRSF11B SLC17A2 ITGAV FGF23 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 HEXB SCARB2 HEXA GM2A PSAP NEU1 NPC1 GLB1 NEU3 NEU4 GLA LIPA NPC2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits SRC NOTCH1 TCF7L2 TCF7L1 CXCR4 TNC LEF1 POSTN VHL VEGFA VCAM1 CYTIP GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GSTM2 GSTT2 GPX2 GSTA5 GSTM1 GPX3 OPLAH HEL-S-26 HEL-S-64p GPX1 GPX4 GCLM HEL-75 GCLC STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 INSIG1 NR1H2 INS DBI YY1 PRKAA2 PRKAG1 PRKAG2 SCARB1 CAMP ACACA LDLR FASN PRKAG3 PPARGC1B PRKAA1 LPL SIRT1 PRKAB2 IDI1 FDPS NFYA PRKAB1 SREBF2 HMGCS1 MVD SAR1B HEL-S-32 CDK8 CYP51A1 MBTPS1 HMGCR ACLY PIK3CA SAR1A RNF139 SEC23B FDFT1 SEC31B SEC31A AMFR SP1 SEC24C MBTPS2 SQLE MED15 FGF21 SCD MTOR ACSS1 PPARG GPAM RBP4 SEC23A GSK3A CREB1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 IRAK4 IRF7 STAT2 MYD88 STAT1 TRAF3 TRAF6 TBK1 IFNAR2 TMPRSS2 TYK2 IFNAR1 MAVS TREML4 RIGI ACE2 TLR9 TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 JAK1 IFIH1 IRF3 TLR3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GLS RPS6KA2 ARAF BRAF PFKFB2 DLD RPS6KA3 MAPK1 HEL-S-30 MAPK3 CPT1A RPTOR MAP2K1 MTOR MAP2K2 HEL-75 MLST8 ACSS1 PDHA1 RAF1 NAMPT PKLR SLC16A3 RPS6KA1 LDHB HEL-S-304 HEL-S-133P DLAT PPARGC1A GPX4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview PLA2G1B MMP9 BMX ANGPT1 PAK1 VEGFA GRB7 SRC KDR SHC1 PLXND1 PDPK1 MAP2K4 MAPK1 KRAS MAP2K6 ATF2 PTPN11 MAPK11 MAP2K1 MAPK14 RAF1 SLIT2 GRB14 MAP3K7 PXN F2 PRKCA ROBO4 PTK2B PIK3CD DAG1 MAPK8 CRK WAS PLCG1 NRP1 SHB TIMP4 BAD VHL MTOR APC CDC42 SEMA3A IQGAP1 FGFR1 ROBO1 NCK1 NOX4 MMP2 FRS2 RAC1 GRB2 SOS1 MMP14 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 CDH2 AK4 PTK2B CCR8 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 UGT1A10 CYP1A2 HSD17B3 CYP1B1 HSD17B7 SULT1E1 HSD17B2 CYP2C19 CYP3A7 UGT2A2 CYP3A4 HSD17B10 HSD17B4 HSD17B1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 MAD1L1 PTTG1 STAG1 CENPE CDC20 BUB1B SMC3 APC ESPL1 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GPR64 PTH2R CALCR ADGRL4 CRHR1 GLP1R ADGRL2 ADGRL3 ADGRE2 GHRHR PTH1R ADGRE5 ADCYAP1R1 ADGRL1 VIPR2 CRHR2 GIPR CALCRL GCGR SCTR TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways BCAT2 PSAT1 BAAT DHFR PSPH AMT CHDH GPX1 PHGDH HEL-S-44 HEL-75 GCLC pcap GAD2 CDO1 MTR HEL-S-75p GAD1 HEL-S-51e MTHFD2 TYMS DNMT3L GPX6 MAT1A HEL-S-64p GPX4 HEL-S-61p GPX2 CBS BCAT1 ALDH7A1 DNMT3B CTH GCLM AGXT2 PCYT1B CHKB AHCYL1 PCYT2 SLC25A48 CHKA BHMT2 ETNK1 AHCYL2 GPX7 PEMT MTHFD1 MTHFD2L CHPT1 GPX3 SHMT1 MTHFD1L CEPT1 HEL-S-182mP 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NLRP3 GDF5 ChAT DKFZp781O1323 JUND ATF2 BCL2 CUL5 SMARCC2 SIRT1 EIF4ENIF1 ELOA BMP2 SF3B1 MYBBP1A MAPK8 ERCC5 RIF1 SIRT6 NEO1 HSF1 MYO1C MEN1 DLD SMAD1 PCNA SMAD9 DDX21 OGDHL FAM170B CEFIP BMPR1A VSTM4 RGMB BAZ1B NOG WDFY4 PARG LRRC18 SLC18A3 ARHGAP22 HSF4 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 ITCH UVSSA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway ARL4A WDCP MIXL1 C9orf72 KLF4 KLF5 GATA3 RGS10 SETD2 HAND1 CTBP2 RPL38 LEFTY1 AMH LEFTY2 ZIC5 TBX6 NR2A1 HES7 SESN1 GATA6 TCF4 C1QBP TBX1 FOXH1 TBX3 CCND1 RARB PLCH1 YAP1 CRTC1 PIAS1 TRIM28 NABP2 DKK1 ACVR1 SMAD1 DNMT3B ACVR2B SCHIP1 SMAD6 BHLHB2 FZD5 BMPR1A FZD8 BMPR2 LATS1 TEAD2 SMAD2 SMAD4 INHBA SLC2A12 HTT TET1 FOXC2 FOXC1 SNAI1 BMP4 POU5F1 CUL4B PITX2 PAX6 MEIS1 SOX2 FOXA1 ARID5B CCDC6 ACACA BMP7 NFE2L2 FOXA2 LEF1 TCF7L1 HMGA2 ACVR2A WNT3 PRKAR1A WNT3A PPP2CA ZIC2 SOX21 SOX17 CEP250 WDHD1 AXIN1 EMSY AXIN2 WDFY2 HPRT1 BCORL1 TOX CSRP2 NLK MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 FGF8 GDF3 ZFHX4 TRERF1 PBX1 EXT1 FZD4 NODAL FGFR1 TRIM71 PHF6 ZIC3 TRIM5 JARID2 VAV3 NOG PARP8 NR1B3 TOX3 AEBP2 EXT2 AHDC1 ZNF462 ADAM19 ELP4 TWSG1 MSGN1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TAF13 TBP H4C9 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD4 RAD51 RAD54B BRCA2 MRE11A POLD2 ATM RAD52 RPA1 NBN POLD3 RAD50 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IF1IB1 TYK2 STAT2 STAT1 IRF9 JAK1 IFNL2 IFNL3 IL10RB IFNLR1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND2 ND5 ND4 TIMMDC1 ND6 NDUFB10 TMEM186 C3orf60 TMEM126B DMAC1 NDUFB11 DMAC2 COA1 NDUFAF6 NDUFAF4 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ACAD9 NDUFB9 NDUFB8 NDUFAF1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 ECSIT NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFA13 NUBPL NDUFAF2 NDUFS3 NDUFA12 NDUFA10 ND1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TSC2 TSC1 ARAF MAPKAP1 NRAS BRAF PIK3CA AKT3 IRS1 EIF4EBP1 MAPK1 KRAS SOS2 MAPK3 RPTOR MAP2K1 MTOR DEPTOR MAP2K2 PIK3R1 MLST8 PARP2 PARP1 RAF1 RPS6KB1 AKT1S1 INPP4B PTEN RICTOR HRAS GRB2 SOS1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R5 PIK3CD PIK3R3 PIK3C2G PIK3C2A PIK3C2B PIK3R4 PIK3R2 PIK3R1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A IL1R1 TGFB1I1 IL1B MAOA ITGB3 TPH2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum XAB2 POLK XPA GPS1 XPC CUL4A POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 SLX4IP GTF2H5 CUL4B SLX4 ERCC2 MNAT1 RBX1 CHD1L RPA3 RPA1 ERCC1 PCNA CETN2 PARP1 CDK7 HMGN1 H4C9 POLD3 H2AC6 RFC1 POLD4 HIST1H4L DDB2 POLE RAD18 BRCA1 H3F3B LIG1 POLE2 POLD2 POLE3 UVSSA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B SMAD2 SMAD4 C1QTNF12 VEGFA COMMD1 PANK4 INTS11 ISG15 INTS13 INTS14 INTS10 GDE1 TMEM52 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK SSU72 TNFRSF14 PEX2 ATAD3C GLTPD1 ACAP3 ELAVL1 RER1 CD160 SCNN1D PEX5 MXRA8 TNFRSF18 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 PEX12 MEPCE PUSL1 TAS1R3 NADK HES4 MRPL20 OR4F5 DVL1 HES5 OR4F3 CDK11A CFAP74 MIB2 PEX10 RNF223 LRP4 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 TRAF5 INTS9 SLC35E2B C1orf159 PLCH2 PRKCZ TGFB1 CALML6 GRIK2 DKK3 ARF6 TRAF2 TRIM25 TNFRSF4 PARD6B PHKG2 RBX1 VTN GNB1 AGRN MCM2 HEL-S-72p IFIT1 ATAD3A UBE2J2 SKI TNLG2B B3GALT6 INTS4 IFIH1 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 OMA1 LONP2 TSC2 SESN2 TSC1 GDF15 LONP1 FOXO1 SLC7A7 EIF2A CLPP MYC IRS1 PHB2 MTOR HSPD1 ATF4 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map TOMM70 SLC6A19 AQR UPF2 IGHMBP2 GDAP2 NLRP12 UBB MACROD1 HEL97 MACROD2 CMTR1 MAP3K7IP1 NRP1 ISG15 PAIP1 PARP14 UBC PALS1 MACROH2A1 ACE2 MACROH2A2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling ITGB1 PIK3CD MAPK10 EGFR COL1A1 MAPK9 MAPK8 NRAS SRC AKT3 TLN1 MAPK1 MAPK12 KRAS MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RAF1 PXN ITGA1 HRAS GRB2 AREG SOS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ERN1 SLC2A4 CD36 PRKCZ PRKAG3 MAPK8 INSR PDX1 RPS6KB1 EIF2AK2 TNFRSF1A INS IRS1 TNF TRAF1 MAFA PPP2CA ACSL1 PIK3R1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 IL1B RELA TRAF3 PYCARD NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CCND2 KLF4 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 WNT5B ELAVL1 WIF1 SOST LEF1 CCND3 NKD1 NKD2 DVL1 DVL2 TCF7L2 DVL3 TCF7L1 SOX7 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 MTDH FRAT1 FRAT2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CTBP1 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response ERN1 BCL2 NFE2L2 MBTPS1 BBC3 XBP1 RTCB HEL-S-89n CASP2 MBTPS2 IL1B PMAIP1 DDIT3 TXNIP TNFRSF10B EIF2S1 PPP1R15A BCL2L11 ATF4 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair PRKDC NASP MDC1 ATM H1-1 RNF168 H4C9 NBN HIST1H4L RAD51 TP53BP1 SETD2 RNF8 SUPT16H XRCC5 SSRP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 FADD CASP9 CASP3 BAX TRAF2 BIRC3 RIPK3 TNFRSF1A RIPK1 TRADD TNF CASP8 CYCS MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 CASP9 CHKA CASP3 PEMT ASMT CHPT1 GRIN1 EHMT1 ALDH7A1 CHDH DNMT3B HEL-S-61p CYCS 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome ATP2A1 RABEP2 SH2B1 INSR TRAF2 SLN NFATC2IP VAV2 TUFM ATXN2L SPNS1 KDR IFITM1 PLN IL4 SDCCAG8 MPL NFATC2 LAT RAB5A CD81 CD82 CD19 PRMT1 HEL-S-62p CR2 RAB4A TRAF1 GRB2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMPR2 NOG SMAD6 TOB2 SMAD4 RUNX2 SMURF1 SMAD1 BMP2 TOB1 BMPR1A RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling MAPK9 PAPSS2 MAPK8 RELA CHUK STAT1 TRAF3 FHL2 RELB TRAF2 GAB2 TRAF6 PLCG1 IKBKG MAP3K7IP1 JUN SRC NFATC1 NFKB1 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 MTOR NFKBIA LYN PIK3R2 SYK PIK3R1 CDC42 TNFSF11 SPI1 TNFRSF11B CBL TNFRSF11A MAP3K7 FOS NFKB2 SQSTM1 IKBKB RAC1 TRAF1 TRAF5 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NFE2L2 MAPK8 NQO1 CEBPB EPHB2 PIK3CA SLC7A11 HMOX1 PRKCA MAF GCLM AIMP2 KEAP1 GCLC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11B PMP22 FIG4 MPZ MFN2 KIF1B RABAC1 MTMR2 EGR2 RAB7A LRSAM1 RAB4B HSPB8 LITAF GDAP1 SH3TC2 FGD4 RAB25 HEL-S-102 RAB4A RAB11A NEFL SBF2 RAB3B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR AHCYL2 MTHFD1 SHMT1 HEL-S-51e MTHFD1L TYMS MTHFD2 DHFR MAT1A AMT TCN2 HEL-S-70p CHDH MTFMT GLRX DNMT3B MTHFS FOLH1 HEL-S-61p FTCD NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK1 FLNA MAPK3 PTK2B RPGRIP1L INVS NPHP1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DOLPP1 MGAT4B STT3A STT3B ALG1 FUT8 B4GALT1 DPM2 MGAT1 MPDU1 B4GALT2 TUSC3 ALG6 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 RFT1 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B DPM1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions FOXO6 WWTR1 KNSTRN RAB13 FERMT3 YAP1 FOXO1 FOXP3 RAP1A ARHA STK38L FYB1 MAPK14 MOB1A PRDM1 LPL FOXO4 FOXO3A YWHAQ CD19 CCR7 LATS1 TEAD4 LATS2 RAC1 TEAD2 TEAD3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 TLR4 IRAK4 IRF7 MYD88 TICAM2 RELA CHUK TRAF3 RELB TIRAP TRAF6 TBK1 IKBKG NFKB1 TLR5 MAPK1 TLR9 TLR7 IKBKE TLR1 TICAM1 NFKB2 IKBKB REL IRF3 TLR8 TLR3 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling TLR4 TIFA IRF7 CISH TREM1 SOCS1 CCL5 RBCK1 CCL4 NFKBIA PTPN6 MLST8 IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B MAP3K7 IL12A PIK3R3 SQSTM1 MBL2 MAPK10 MAPK9 MAPK8 SFTPA2 LBP CYLD TLR5 CXCL8 CASP8 SPP1 ZMYND11 PIK3R2 SYK PIK3R1 PLK1 IRAK3 PELI1 SMAD6 FADD IKBKB RAC1 CXCL11 IRF3 CD14 TLR8 TLR3 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 FBXW5 LY96 IFNA21 TRAF3 CD180 IF1AA9 TRAFD1 TIRAP SIGIRR CUEDC2 SFTPD MAP3K7IP1 RNF31 PELI3 SARM1 TNFAIP3 IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RIPK1 IFNA7 TICAM1 NFKB2 BTK IRAK1 IRAK2 PIK3CD IRAK4 TAB3 MYD88 OTUD5 CHUK TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 IFNA2 TLR9 TLR7 TMED7 PIK3R5 RNF41 FOS IFNB1 IL1B CXCL9 IFNA1 CCL3 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response IL15 TGFB1 CSF3 CXCL2 PDGFA IL10 IL13 HLA-DRB1 IL2 IL4 IL6 IL5 IL7 CSF1 IL11 TNF HLA-DRA IL3 IL12B IFNB1 IFNG IL1B CSF2 CXCL1 IL1A PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA4 PSMA2 PSMC1 PSMB6 PSMB2 PSMB3 NEDD4 UBE2D1 PSMD9 PSMB10 HLA-A UBE2B HEL-S-276 PSMD6 PSMB8 HLA-B HEL-S-283 PSMD7 HLA-F PSME2 HLA-G HLA-C HLA-E PSMD4 PSMD5 PSMD2 UBE2D3 PSMD3 PSMD1 UBE2D2 H2AX UBB HIST1H2AB H2AZ1 PSMD10 UBA7 PSMD12 PSMD11 HEL-117 HEL-S-91n PSMD13 RPN2 UBC RPN1 IFNG PSMC6 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA NR1i1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways MEF2C CREBBP EP300 CTCF ASCL1 CAV3 CEBPB SCN3B NKX2-2 BDNF GATA3 SNTA1 GATA2 SCN4B HDAC9 NKX3-1 YBX1 TLX3 POU3F2 PHOX2B C4B_2 SST POU2F2 C4A IL6R TCF3 DLX2 HIF1A G6PC1 GCK TF RORA MAP2 PAH IL10 HEL-S-162eP IL13 CXCL8 CHRNB2 CPT1A ECE1 EN1 BHLHB2 CREM PPARGC1A IL1RN EGR1 FREP1 IL1A AQP4 TACR1 SLC9A3 FOXM1 VEGFA TPH2 POU5F1 TPH1 ChAT GRIN1 FEV CTNNB1 PKNOX1 TNF TSPYL1 CHRNB4 DEAF1 SPTBN1 PHOX2A SOX2 MYB NR3A2 CC2D1A HEL2 NOS1AP KCNJ8 GPD1L HEL-S-125m LMX1B AVP CHRNA7 PPARGC1B HADHB 5HT1A GJA1 NR3C1 HDAC1 NEUROD1 HES1 NFYA HES5 NFKB2 PRKAR1B PRKAR1A REST SP3 RET ACADM CHRM2 SCN5A TP73 CASP3 HTR2A JUN NFKB1 SLC25A4 IL6 NTRK2 SP1 DDC NR1A2 MAOA HEL-S-87p ADCYAP1R1 VIPR2 GNB3 SNAP25 PBX1 SSTR2 RYR2 SLC1A3 YWHAQ TH HEL-S-1 YWHAG YWHAZ NGF CREB1 RUNX3 IL1B HSPD1 VAMP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2C19 CYP2C9 CYP2B6 CYP2C18 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 TMEM120B MDH2 TMEM120A SSC4D POR RAF1 STYXL1 HEL163 PTPMT1 KIF1C SFN EPB41L3 YWHAG LMNA RHBDD2 ZP3 ZP2 HEL-S-102 DAPK2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling STAT2 STAT1 MAPKAP1 GAB2 MAP3K1 VAV1 ZAP70 TYK2 SOCS3 SOCS1 IRS1 MAP2K3 EIF4EBP1 PTPRC FYN MAP2K6 RPTOR PTPN11 MAPK14 PTPN6 MLST8 EIF4E EIF4B RPS6KA4 RPS6 IRF9 RPS6KA5 RPS6KB1 PRMT1 REL LCK PIK3CD STAT3 STAT4 IFNAR2 CRK PIAS1 IFNAR1 RAP1A CRKL MTOR PIK3R2 PIK3R1 EIF4A1 RAPGEF1 CBL CREB1 RAC1 JAK1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD AGPS LPIN1 IPMK LPIN2 PIK3CA HMFN0839 PLA2G2A PI4K2A PTDSS1 CHKB PCYT2 PTPMT1 GPAM PEMT MOGAT3 GPD1 CHPT1 PGS1 CEPT1 CRLS1 GPAT2 GPAT4 CDS2 PIP5K1A GNPAT CDIPT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA CMKLR1 PIK3CD FPR2 EPHB2 MTOR GRK1 LTB4R HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 CD36 HIF1A HEL-S-133P PPARG GPD1 HEL-S-49 HEL-S-162eP NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2 POLA1 MTHFD2 OAZ1 DHFR HPRT1 POLG RRM2B ADSL NME2 SRM IMPDH1 ADSS FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 FABP4 CEBPA KLF5 INS PIK3CA GATA3 GATA2 PLIN1 NR1C1 MGLL KLF2 LMNB2 PNPLA2 PPARG LPL LIPE ZMPSTE24 FNTA BANF1 LMNA CIDEC ICMT PRRX1 STAT5B CIDEA SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 SLC6A19 FURIN ACAT1 CTSL TMPRSS4 ACE2 NRP1 TLR7 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP1 AGPS LPL GPAM MOGAT3 GPD1 LIPF LIPE AGPAT4 AGPAT5 MOGAT2 MOGAT1 AGPAT3 DGAT1 GNPAT LIPC DGAT2 PLPP3 PNPLA2 PLPP2 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 TIFA UBE2V1 NFKB1 SQSTM1 PRKCZ HEL-S-71 TRAF6 IL1A AJUBA SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RAF1 RASGRF1 HTR2B NRAS HTR2A GATA4 MAPK1 KRAS MAPK3 HRAS MAP2K1 MAP2K2 MAPKAPK2 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade MAPK10 MAP2 ARAF MBP NRAS BRAF MAP3K1 MAP3K2 JUN LAMTOR3 RRAS MAP2K3 MAPK1 MAP2K4 MAPK12 KRAS SOS2 MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 RASA3 RAF1 SIPA1 PLCB3 HRAS GRB2 MAP3K12 SOS1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 PIK3CD PTGS2 BAX CRP CCND3 COL4A1 HMOX1 PTGS1 IL6 NFRKB AKT3 CXCL8 TNF LAMA3 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing OAS1 TREX1 RNASEL ADAR RNASEH2C IFNB1 RNASEH2B RNASEH2A MAVS RNASET2 CGAS RIGI MITA IFIH1 IRF3 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies USP9X ADCY6 XPNPEP3 DYNC2I2 CEP19 INVS NPHP3 DYNC2H1 DYNLT2B SUFU DYNC2LI1 KIF7 OCRL RP1L1 IFT172 PKD1 DNAJB13 PIK3R4 RSPH9 SMO AHI-1 IFT81 TCTN3 CENPF GPR161 TCTN2 INTU TCTN1 RSPH3 ALMS1 HEL-S-296 IFT27 CC2D2A RPGRIP1L RSPH1 TMEM138 SPAG1 NPHP1 TULP1 PIBF1 CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 C2CD3 B9D1 RAB23 B9D2 CCDC41 KIAA0753 CCDC40 OFD1 ANKS3 BBIP1 PDE6D NEK9 PLK4 ZNF423 CRX TRAF3IP1 CEP164 FLCN IFT52 TMEM107 ODAD1 CNGA1 ODAD3 NEK1 ODAD4 BBS9 CCDC28B BBS7 MCIDAS IFT57 NME7 TBC1D32 BBS5 NEK2 CEP290 DNAAF3 DNAAF2 ZIC2 BBS4 DNAAF6 IQCB1 CFAP418 FAM161A CCNQ IFT140 IFT80 CCNO CFAP410 AK7 CEP78 WDR35 LZTFL1 DNAAF19 ARL2BP EVC DNAL1 BBS10 DNAAF11 IFT43 HYDIN BBS12 CCDC39 RP2 MAK CFAP52 DNAI2 TMEM216 TOPORS EFHC1 WDPCP RP1 NME9 WDR51B CNGB1 ZMYND10 SDCCAG8 CEP104 KIZ ARL6 CFAP53 ARL3 KATNIP DNAH6 PKD1L1 PKHD1 CFAP298 ARL13B POC1A TMEM67 RAB28 INPP5E DNAI1 EVC2 TUB BBS2 DYX1C1 NEK8 RPGRIP1 BBS1 TTLL5 PCARE HYLS1 SCLT1 ATXN10 DCDC2 TTC8 MKS1 CEP41 TRIM32 GLI3 CLUAP1 DRC1 CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis SCARB1 NR1H4 LDLR SLC22A1 ABCC2 ABCB4 SLCO1A2 HMGCR ABCC3 ABCB11 EPHX1 RXRA NR1I3 ABCG8 ABCG5 ATP8B1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 GOT2 SLC25A12 GLUD1 SLC25A13 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYP11A1 SRD5A2 POR HSD17B6 STAR AKR1C4 AKR1C2 HSD17B3 CYP17A1 HSD3B2 FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism RELA INSR CRP FLAD1 DHFR INS CSF1 TNF GPX1 CCL2 HEL-S-44 SCARB1 APOB SERPINA3 LDLR SLC19A1 MTRR SAA4 HBB MTR PLAT FOLR1 PLG HEL-S-51e MPO MTHFD2 ABCA1 FGA HBA2 GPX6 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG ALB SAA1 SAA2 GPX4 GPX2 CBS NFKB1 IL2 IL4 IL6 CTH MTHFS SLC46A1 IZUMO1R FOLR3 MTHFD1 FOLR2 GPX3 SHMT1 IL1B INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB1 PAK1 ARHGEF7 VASP CAV3 BRAF VAV2 CAPN3 DOCK1 SRC SHC1 ZYX PDPK1 AKT3 MAP2K3 MAPK1 MAPK12 FYN MAP2K6 MYLK2 MAP2K1 SHC3 MAP2K2 HEL-S-28 RAF1 HEL114 ITGB3 ITGA2B RAC3 PXN CAPN10 ITGA1 PAK6 SELENOP PAK4 ITGA2 ITGA4 MAPK10 ITGB7 MAP2K5 ARAF RHO CRK ROCK1 CAPNS1 ROCK2 MAPK7 RAP1A CAV2 TLN1 PIK3R2 CDC42 RAPGEF1 MYPN ITGAM ITGB5 ITGB4 CAPN9 CAPN6 ITGAE CAPN7 CAPN5 ITGB8 TNS1 ITGAV GIT2 ITGAX ITGB6 CAPN11 VAV3 MAPK6 ITGA7 ITGA6 MAPK4 RAC1 HRAS CSK GRB2 SOS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIST1H4L H2BC12 CHAF1A RBBP4 HIRA H4C9 SMIM40 IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling TICAM2 RELA CEBPB FAS CTNNB1 CSN2 MAPK1 TNF MAPK3 IL18R1 NFATC4 NFKBIA ELAVL1 IL37 PRKAA1 TNFSF6 NCF1 RPS6KB1 PRKCB MAP3K7 IRF1 PRKCA ACACB HEL-S-102 LCK CYCS GSK3B IRAK1 MAPK9 MYD88 CASP3 CHUK IL18RAP BAX TRAF6 TNFRSF1A GATA1 NFKB1 SP1 CASP8 PIK3R1 PARP1 NCF2 IMP3 SLC12A3 GRIN2B PTEN IL18 IKBKB NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium GSK3B MAP1B MEF2C GHRL NGFR APP ID2 ASCL1 MAP2 STAT3 CXCL12 MRE11A ID1 BDNF KDM1A PLXND1 CDK5R1 MYC NTRK2 PAX6 NRG1 ERBB4 DAB1 AGRN SOX2 DISC1 NUMB NOTCH1 PSEN1 PAFAH1B1 NEUROD1 RTN4 NDEL1 HES1 TCF4 LRP8 NTRK1 TCF3 NEUROG3 FAIM NTRK3 NGF RELN VLDLR CDK5 IL17A RET RTN4R CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K1 IGF1 TGFBR1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 NFATC2 MAP2K1 MAPK14 MAP2K2 CDK9 EGF RAF1 IKBKE FGFR2 MAP3K7 PRKCA PRKD1 GSK3B MAP2K5 MAP4K1 MAPK8 TGFB1 CHUK IKBKG TNFRSF1A MAPK7 NFKB1 MAP3K14 MTOR CALM1 CDK7 FGF2 NPPA GUCA1A IKBKB PPP3CA RAC1 CAMK2D 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome METTL27 STX1A FKBP6 VPS28 ATPAF1 TRIM50 HDAC2 FBLN2 ATP8 FBLN5 ATP6 MVB12A CLASP2 ATP5MC2 TMEM270 TBL2 ATP5MC3 GTF2IRD1 FAS CTNNB1 CLDN1 MYC ATP5G1 PRKG1 NRG1 HDAC6 MAPK3 ABHD11 TSG101 ACACA MLXIPL H2AX USF1 HEL-S-123m FBN1 EIF4H ATP5PB EIF2A ATP5F1D GTF2I ATP5F1E SQSTM1 ACACB ATP5PO RB1 BTK SF3B1 ATF4 MYBBP1A HEL-S-15 HMGA1 RFC2 CHTF18 CLDN3 UBE2L6 CDKN1C HEL-S-162eP MYO1C CLASP1 DLD LIMK1 GRIP1 ULK1 SNAP25 CLDN5 CLTC PCNA CLDN4 BRD4 LAT2 PKLR NUP62 DDX21 UBIAD1 FZD9 OGDH BAZ1B BCL7B BUD23 VPS9D1 HDAC3 ATPAF2 UBE2E3 SMARCA5 VPS37C HSPA2 DEK HEL-S-271 UBE2E1 VPS37D GRB2 VPS37A HOXC8 VPS37B CLIP2 VAMP2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB4 TLR4 CAMK2A PLCB1 PLCB2 STAT2 STAT1 IFI44L NRAS IFI27L2 CAMK2G RSAD2 TYK2 ISG15 CYP27B1 RXRA MAPK1 TNF NR1i1 MAPK12 KRAS MAPK3 MAPK13 CCL2 MAPK11 MAPK14 CAMP OAS2 DEFB4B CD40 PRKCH IFNGR2 PRKCB PRKCE PRKCA NFKB2 CD40LG IFNG PRKCQ SP3 RXRB NOD2 PRKCZ MAPK9 RXRG CYP24A1 MAPK8 RELB PLCG2 IFNAR2 IFNGR1 JUN TNFRSF1A MAPK7 NFKB1 IL6 SP1 CXCL8 IFNA2 PLCE1 PLCB3 IKBKB JAK1 HRAS CAMK2D TLR8 MED1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17RA IL17A SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 HMGB1 IKBKB THBD CHUK RELA NFKBIA IKBKG AGER MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression GABPB1 TFAM PPARGC1B MYEF2 HCFC1 POLRMT GABPA MTERF3 MTERF1 NRF1 SP1 CREB1 PPP3CA PPARGC1A TFB1M TFB2M PPRC1 ESRRA CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network RAD54B SMUG1 REV3L ERCC2 POLI FANCD2 FAN1 H2AX FEN1 MPG PNKP OGG1 NBN UNG RFC1 POLD3 POLD4 NTHL1 DDB2 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 NEIL2 APEX1 POLE3 RAD52 CHEK1 WDR48 XPA XPC CUL4A ERCC5 RFC2 GTF2H2C_2 CCNH MSH6 GTF2H2 FAAP24 GTF2H3 MSH2 BRIP1 GTF2H5 FANCM MNAT1 CENPX RAP1A FANCL REV1 WRN FANCA POLM NHEJ1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C PARP2 ERCC1 CENPS CETN2 CDK7 ATM ATR BRCA1 BRCA2 POLD2 XRCC5 TDG POLE4 MRE11A MSH3 DDB1 RAD50 CUL4B RAD51 HMGB1 RPA3 RPA1 MGMT POLK RFC3 RFC4 RBX1 PRKDC PCNA PARP1 TERF2 PMS2 USP1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF5 MED23 TAF8 MED27 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 MED30 MED31 POLR2M POLR2L TAF10 TAF11 MED14 TRFP CRSP9 TAF1 TAF4 TAF3 POLR2A THRA CDK8 POLR2D GTF2B TAF9 CTDP1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TAF13 MED15 TAF7 TAF6 TBP CCNC TAF12 MED9 NELFB NELFCD NELFA POLR2C MED1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1D HTR1B HTR1F GNAI1 STAT3 BRAF HTR2A MAP3K1 GNAI3 PIK3CA MAPKAPK3 PDPK1 RAP1A MAP2K3 MAPK1 ARHA MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 GNAO1 5HT1A RASGRF1 RPS6KA5 FOS CREB1 MAPKAPK2 HTR1E GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS ALDH5A1 GAD2 GLS2 GAD1 PON3 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 PARP1 NAMPT SIRT1 SIRT3 SIRT6 NADK NRK SIRT4 NT5E SIRT5 SIRT7 NMNAT3 NMNAT2 SIRT2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GCK UXS1 PGM3 HK3 HK2 GFPT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB GC CYP27B1 CYP24A1 RXRA DHCR7 NR1i1 PTH CYP27A1 CYP2R1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH RAF1 PRKAA1 NFKB1 PRKCA DUOX1 RAP1A CLCN5 CREB1 HEL-S-5 PRKAA2 SLC5A5 MAPK1 DUOX2 MAPK3 TSHR MAP2K1 TG MAP2K2 CGA TPO NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6R IL6 SOX4 IL11 STAT3 RELA IL11RA JAK1 JAK3 IL6ST PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 PTGER1 PTGER3 PRL PTGS2 ANXA6 EDNRA AKR1C1 AKR1C2 S100A6 SOX9 EDNRB CYP11A1 ANXA2 PPARGC1B PPARG PTGFR HPGD AKR1B1 EDN1 PTGS1 HEL-S-7 TBXA2R PTGDR PTGIR PTGIS PTGFRN PPARGC1A ANXA3 PTGER4 ANXA4 ANXA1 SCGB1A1 PTGER2 S100A10 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A8 SLC30A2 SLC30A5 SLC39A14 SLC30A4 SLC30A1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC39A8 MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACSL3 HSD17B10 EHHADH ACADSB ACADL DECR1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling ADCY3 PLCB1 MYL12B GNG2 STAT1 BRAF IGF1R SRC PDPK1 CDK4 MAP2K3 CDK2 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 RAF1 CDKN1B RPS6 CCND3 RPS6KB1 RBL2 RB1 APEX1 KCNIP3 GNAI1 STAT3 TSHB RAP1GAP SCRIB GNAI3 PIK3CA RAP1A GNB1 GNAS TSHR MTOR CGA GNAO1 PIK3R2 PIK3R1 CCNE1 RPS6KA1 PDE4D GNA13 CREB1 JAK1 HRAS PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NOTCH1 RBPJL CTNNB1 FGF10 PTF1A PDX1 RBPJ KAT2B PROX1 NKX6-1 HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MMP9 SRD5A2 CREBBP SIRPA EP300 CHD2 SOX5 TRIP13 ERCC2 CYP26B1 HLA-DRA PON2 CDK9 PON1 APOB TMEM132E CYP17A1 RFC1 PEX10 AHR HMGA1 XPC CCNK PRDM9 REC8 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 SPATA17 TSSK4 DDX4 DAZ4 THBS1 DAZ3 VCX DAZ2 CLU MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 FOLH1 PIWIL4 GNAO1 SPO11 XRCC3 HORMAD2 MSMB ERCC1 PRMT6 PACRG TEX15 CXXC1 ABLIM1 OR2W3 P1 USP26 NQO1 CDC42BPA MDM2 MLH3 ATM CTCFL ABCB1 SEMG1 CYP1A1 BRDT BRCA2 MMP2 DND1 FAT10 XRCC5 INSR PSAT1 KDM3A FAS AHRR UBE2B TNF MAS1L GPX1 NR3A2 BCL2 MTRR SLC16A7 NFE2L2 MTR TNFSF6 TCN2 MSH4 HEL-S-61p AGO2 STRA8 POLG HEL110 NOS2 PARP1 SLC46A1 PEMT MTHFD1 SHMT1 H4C9 DAZL PMS2 H3-4 ETV5 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease ANGPT2 SMAD2 LTBP1 SMAD4 MAPK8 NR2C2 RUNX2 FBN1 TGFBR3 CTGF FBN2 TGFBR1 FBN3 LTBP2 SHC1 MAPK1 FLNA ENG MAPK3 POSTN MAPK14 TGFBR2 AGTR1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 CS SDHC SDHD SDHB SDHA OGDH ACO2 IDH3B FH SUCLA2 DLD SUCLG2 SUCLG1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN ACE2 VEGFA NRP1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 HSD11B2 EBP SLC27A5 THEM5 DHCR7 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 ACOT9 AMACR ACOT6 SLC27A2 NPC1 ACOT4 DBP CYP7A1 EPHX2 CYP27A1 NPC2 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway MMP9 EGFR SMAD2 RELA STAT1 INSR TIRAP INHBB FOXO1 SRC INS SHC1 IRS1 MAPK1 MAPK3 ATF2 HEL-S-44 MAP2K1 MAPK14 NFKBIA RAF1 ALPL NCF1 AGER PRKCB PRKCA HIF1A STAT5B EZR CYCS IRAK4 CASP9 PRKCZ MAPK9 MAPK8 MYD88 CASP3 CHUK STAT3 ROCK1 JUN NFKB1 SP1 CASP8 ARHA NOS2 CDC42 FOXO4 DDOST HEL70 MSR1 MMP7 IKBKB MMP2 RAC1 MMP14 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 ABCC2 SLC51A SLC51B SULT2A1 ABCB1 BAAT ABCC3 SLCO1B1 ABCB11 CYP3A4 NR1I3 NR1i1 CYP7A1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 CDKN1A HIF1A ABCB1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation HEL70 CNP MBP GAP43 FREP1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome NKX2-5 CDC45 CYP26A1 HIRA HIRIP3 PAX3 CYP26B1 GBX2 HEL25 SLC2A4 CYP26C1 FGFR2 SREBF2 TBX1 GSC2 HAND2 PAK4 CDH15 ACTA2 RORC CLDN3 PARK2 SLC25A1 HEL-S-80p DGCR8 DROSHA CRKL GP9 SNAP29 PLK1 SERPIND1 SEPT5 TXNRD2 TSKS ZDHHC8 RCC1 C22orf39 DRD2 THAP7 TSSK2 RTL10 HDAC3 NPRL2 TRMT2A ESS2 KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L GP1BA TNPO1 ASF1A SCARF2 EGFR DGCR2 GP1BB C16orf35 SLC7A4 GNB1L DEPDC5 FOXC2 CCDC188 FOXC1 ARVCF RANBP1 P2RX6 SHH ZNF74 PITX2 FGF10 CLDN1 NCOR1 BCL2 RAF1 FOXA2 RTN4 HES1 ALDH1A2 EMC10 POLR2A RELN RTN4R RBX1 MED15 FGF8 CLDN5 CDC42 UFD1L FGFR1 GLUD1 H4C9 CLTCL1 VWF RAN SHOC2 PRODH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling EGFR CREBBP STUB1 SMAD4 EP300 RUNX2 RELA FHL2 FOXO1 EFCAB6 HEL32 SRC KAT7 KDM1A PIAS2 CTNNB1 ZNF318 FKBP4 RNF6 RNF4 TGFB1I1 BAG1 FLNA PATZ1 NCOR1 SMIM40 UBE2I SUMO1 SIRT1 HDAC1 TGIF1 RB1 PAK6 KAT2B CCND1 ZMIZ1 GSK3B RAD9A STAT3 TLE5 PIAS1 ROCK1 KAT5 ROCK2 UBE3A JUN HEL-S-99n PSMC3IP SP1 ARHA RLN1 PIK3R2 NCOR2 PIK3R1 CDC42 NR2C2 RHOB MDM2 CCNE1 HEL-S-67p NR0B2 PTEN BRCA1 CREB1 RAC1 RAN SIN3A CARM1 LIMK2 NCOA1 SMARCE1 ETV5 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFD HEL-S-62p ICMT LMNB2 RCE1 FNTA LMNA CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 MDH2 ALDH7A1 HEL-S-5 GCDH L2HGDH D2HGDH APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3B BCL2L1 BCL2 BCL2L2 BAK1 ITGB4 BAX BOK PTHLH GSK3A MYC AKT3 BCL2A1 BCL2L10 ITGA6 BCL2L12 BCL2L14 MCL1 BCL2L13 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis GAD2 PAH GAD1 ASMT TH TPH1 ChAT AANAT DDC ACHE MAOA HDC PNMT DBH LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 TRIM71 EGR1 SOX2 POU5F1 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ITGB1 MYL12B DCC SLIT1 SHH SLIT3 TRPC1 SRC PDPK1 MAPK1 MET FYN RYK gdf7 SEMA5B RHOD ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 RAF1 ABLIM3 ROBO2 LRIG2 CXCR4 SRGAP2 NTNG2 NGL1 SLIT2 EPHA2 PRKCA WNT4 NTN3 PARD3 CDK5 ARHGEF12 GSK3B RGMA HEL-S-15 PRKCZ EPHB1 GNAI1 CXCL12 ROCK1 NRP1 PARD6A RRAS PLXNA1 PTCH1 EFNA1 CDC42 SEMA3A BOC L1CAM FES FZD3 ROBO1 NCK1 BMPR2 RAC1 HRAS CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NCOA6 ABCC2 DNAJC7 SULT1A1 FOXO1 UGT1A4 CYP2C19 SP1 CYP3A4 RXRA NR1I3 UGT1A3 CYP2C9 CYP2A6 CYP2B6 SULT2A1 UGT1A1 EHHADH ABCB1 UGT1A9 ABCC3 SMC1A PTPA PPARGC1A CYP4A11 ALAS1 NCOA1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 OAS1 STAT1 IFI35 IRF9 IFIT3 IFNAR2 PIAS1 IFNGR1 IFNGR2 TYK2 IFIT1 IRF1 IFNAR1 IFITM1 PSMB8 SOCS1 IFNG JAK1 MX1 TAP1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FST SMAD4 KRTAP8-1 BMP6 IGF1 MSX2 EGR2 BMP4 SFRP1 CD200 PERP GATA3 CTNNB1 CD34 CASP14 MSX1 SOX2 SOSTDC1 TP63 NOTCH2 ADAM17 NOTCH1 ZBTB16 WIF1 NR3C1 LEF1 HR Nbla10317 ATL1 HOXC12 KRTAP3-3 PHLDA1 IGFBP5 KRTAP15-1 SPINK6 SPINK5 TCF4 ADAMTS20 DSG1 TCF3 DSG4 IFNG GPR49 DLX3 KLK5 KLK4 GPRC5D LRIG1 KRTAP6-1 FOXE1 KRTAP2-4 GSDMA KLK13 KLK14 FOXN1 GTPBP4 KRT19 GJB6 KITLG GAS1 DKK3 FOXQ1 CTGF JUN NFATC1 NFKB1 DKK1 DKK4 RBPJ SMAD1 ELANE SOX9 DSC2 FZD1 BMPR1A FOS S100A4 RUNX3 KLK6 CD133 FOSB ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1A2 RELA CHUK GUCY1B1 IKBKG TMPRSS2 HMOX1 NFKB1 IL6 CXCL8 RXRA TNF CCL2 ACE2 GCLM NFKBIA GCLC NFE2L2 NQO1 SLC7A11 IL12A IKBKB IL1B MMP3 IRF3 KEAP1 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B10 UGT2B4 PGM2 UGT1A8 PGM5 UGT2B7 UGT1A3 UGT1A10 UGT1A1 UGT2B28 UGT1A9 UGT1A5 UGT2B11 UGT1A4 UGT2B15 UGT2B17 UGT1A7 UGT2A2 PGM3 UGT2A1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 MTR FOLR1 MTHFD1 MTHFD2L SHMT1 HEL-S-51e TYMS MTHFD2 DHFR HEL-S-70p MTHFS FTCD IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 HSCB ABCB7 FDX1 NFU1 FDXR CIAO2B FXN ISCU NUBP1 NUBP2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF EGFR RAF1 CASP3 HTT RPS6KA5 BDNF NTRK2 CREB1 MAPK1 MAPK3 HRAS MAP2K1 MAP2K2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND2 PRL EPOR STAT1 STAT3 EPO CISH NRAS PRLR FOXM1 IFNGR1 SOCS2 CDK4 SOCS3 IL6 SOCS1 AKT3 KRAS RPTOR GHR MTOR MLST8 GH1 CCND3 IFNGR2 AKT1S1 IL6R IFNG STAT5B HRAS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH ME1 BRAF HEL-S-32 PDP2 ME2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 UGT2B4 CYP8B1 SLC27A5 ABCB4 SULT2A1 NR0B2 SLCO2B1 BAAT ABCB11 FGF8A FKBP5 CYP3A4 RXRA PPARGC1A IP6K3 CYP7A1 NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation TLR4 COX1 MAPK8 CHUK RELA JUN ASCC1 FOS NOS2 MAPK14 MTOR NFKBIA COX2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CREB1 MTR ADH5 CEBPB CBS CYP2E1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ASS1 ARG2 GLUD1 ARG1 ALDH18A1 SMS OTC HEL-S-29 HEL-S-5 SRM HEL-S-20 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFB10 NDUFB11 CEBPA COX7A2 NDUFV3 NDUFV2 SOCS3 NDUFC2 NDUFC1 PRKAA2 NDUFS6 NDUFS5 NDUFS4 CCL2 NDUFS1 COX2 NDUFB9 BCL2L11 NDUFB8 PRKAG1 NDUFB7 PRKAG2 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 PRKAG3 NDUFB1 BBC3 NDUFA7 LEPR NDUFA6 PRKAB2 NDUFA5 ZNF183 NDUFA3 PRKAB1 NDUFA2 IL6R PIK3R3 ADIPOR1 NDUFAB1 ADIPOR2 VCAM1 MAPK9 MAPK8 TGFB1 BAX COX7B COX4I1 COXFA4L2 COX6A1 CXCL8 DDIT3 CASP8 COX8A PIK3R2 COX6B1 PIK3R1 COX7A1 SDHC XBP1 SDHD UQCRB SDHB COX3 CYP2E1 UQCR11 UQCR10 GSK3A CYB UQCRH UQCRQ UQCRC1 IKBKB UQCRFS1 CYC1 RAC1 UQCRC2 IL1A BAK1 INSR RELA INS FAS NR1C1 AKT3 IRS1 RXRA TNF MAP3K5 MAP3K11 ERN1 NR1H4 MLXIPL PRKAA1 TNFSF6 COX4I2 NR1H3 EIF2S1 CYCS ATF4 GSK3B LEP COX1 PIK3CD CASP3 TRAF2 SDHA JUN TNFRSF1A NDUFC2-KCTD14 PIK3CA COX6B2 NFKB1 COX7B2 MLX IL6 COX8C MLXIP UQCRHL NDUFA13 CDC42 PKLR COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 IL1B NDUFA9 NDUFA12 NDUFA10 COX6A2 ITCH COX7A2L SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B2 SLCO4C1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 NR3A2 SULT1E1 HSD17B1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 B3GALT2 B3GALT1 FUT3 FUT1 FUT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin ANGPT2 ANGPT1 VEGFA GATA2 CX3CL1 CCL8 CCL5 MAP2K4 HLA-G CCL7 TNF MAPK3 CCL2 IL15RA CCL4 MAPK11 NR3A2 BCL2 PGR CXCR4 NR3C1 IFNG STAT5B JAK3 MCL1 VCAM1 IL2RB ITGA4 IL15 IL2RG CXCL12 IL10 IL4 IL6 CXCL8 GAB3 NCR2 MADCAM1 KIR2DL4 IL3 SELL CD69 PIBF1 JAK1 CXCR3 CXCL11 NCR1 NCR3 CCL3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 CHDH SLC44A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ITGB1 CLDN4 ZEB2 TGFB1 ALPL SFRP1 TERT MYC ITGA6 TNF NRG3 ERBB4 CCND1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK1 TLR4 IRAK4 IRF7 MYD88 CHUK TRAF3 TIRAP TRAF6 TBK1 IKBKG MAP3K7IP1 TRAM1 NFKB1 IL6 CXCL8 TNF INPP5D NFKBIA IRAK3 IKBKE RIPK1 MAP3K7 TICAM1 IFNB1 IKBKB IRF3 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell AP3D1 ARCN1 SPCS3 NEDD4 LAMTOR5 HEL-S-30 MET POGLUT3 AXL TPM3 TPM1 GYS1 RAB34 TMEM59 MAP3K8 NCL PTMAP7 RHEB LAMC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 SDCBP GAS2L1 TNFRSF10B VCAM1 HMGA1 SLC4A10 NF2 TBCA CHMP2A SRPRB DKFZp761E1322 PICALM THBS1 ADAR SYNE2 TUBA1A FBXW11 SMAD1 CTDSP1 SIGMAR1 SEC23A HSD17B12 UBE2J1 DNAJB1 POLR2C SPTLC1 POLD2 TGFBR2 SH3BP4 ATP6V1C1 ATP6V1F GFPT1 PDLIM7 SLC12A2 GALNT7 GALNT1 ATP6V0E1 FMNL2 CPNE8 VEZT CUL4B BET1 PWP1 PNP DHX57 CIAO2A GOLGA7 FNDC3B FNDC3A PISD RTN4 POM121 HES1 MRPL20 COMMD9 SLC38A1 PEDS1-UBE2V1 MOV10 RARS1 ANP32B RNP24 NRP1 HEL-S-26 ARF4 TRAM1 HMOX1 MAGT1 MRC2 TMEM43 HOXA7 SH3BGRL3 TMED7 ANXA2 E2F3 ATP2A2 ELOVL5 AP2A1 PRPF40A YWHAQ CSDE1 FGF2 P4HA2 PXDN MRPS33 AKAP8 PPP1R7 MPZL1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MCAT HSD17B12 ACACA MECR OXSM HTD2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-117 ADH6 ALDH2 HEL-S-53e HEL-S-4 CYP2A6 CYP1A2 CYP1A1 CYP2E1 ADH1A ADH1C CYP3A4 CYP4A11 ADH7 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB NR1B3 RXRG RARA RXRA RARB DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 FST TGFB1 ANOS1 CELSR1 BMP4 SHH SPRY1 GRIP1 PAX2 SIX1 SMAD1 BMPER SMO GPC3 CRIM1 BMP7 BMP5 CTDNEP1 RARA HOXD11 FRAS1 HOXA11 FREM1 FREM2 GLI3 SALL1 ETV4 SIX2 BMPR1A BMPR2 NR1B3 EYA1 GDNF BMP2 CCND1 DCN RET ETV5 RARB HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis FECH UROD UROS HMBS CPOX ALAS1 ALAS2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex FLT3 GABPB1 BCL2L1 BCL2 SMARCA4 CREBBP ETV6 SMAD4 EP300 FOXO3A ZFX ATM GABPA PTEN TERF2 DNMT3B MCL1 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism ADSL PNP HEL-S-70p XDH AMPD1 APRT IMPDH1 ADA ADSS DGUOK HPRT1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling ITGB1 MAP4K1 MAPK8 PAK1 PTGS2 STAT3 CRK JUN DOCK1 SRC PIK3CA RAP1A HGF MAPK1 CRKL MAPK3 MET PTPN11 MAP2K1 MAP2K2 RAPGEF1 RAF1 PXN FOS PTEN ITGA1 PTK2B HRAS GRB2 SOS1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK1 TLR4 IRAK4 IRF7 MAPK8 MYD88 RELA CHUK TRAF3 RELB TRAF6 IKBKG IL10 MAP3K7IP1 NFKB1 IL6 CXCL8 TNF CCL4 ELANE MAPK14 NFKBIA TLR7 MAP3K7 IRF1 NFKB2 IKBKB LCN2 REL TLR8 CCL3 VCAM1 IL1A AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy DKFZp762B153 RB1CC1 WIPI2 ATG5 ATG14 AMBRA1 PRKAA2 RPTOR MTOR ULK1 PIK3R4 DEPTOR PRKAG1 MLST8 PRKAG2 ATG3 PRKAG3 PRKAA1 ATG9A ATG12 PRKAB2 ATG16L1 PRKAB1 AKT1S1 ATG101 UVRAG PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling P2RY11 ADORA2B GNAI1 P2RY6 P2RY4 P2RX6 GNAI3 P2RY2 P2RY1 PANX1 GNAS GNAO1 ADORA2A P2RY10 P2RY14 GNAZ P2RY8 GNAT2 GNAT3 GNAT1 LPAR4 P2RX7 P2RX5 GNA11 P2RX4 P2RX3 P2RX2 P2RX1 P2RY13 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions TLR4 NLRP3 MMP9 EGFR SMAD2 CNP EBI3 SIRPA FAM20C STAT1 PDGFA MBP CD47 IGF1 VEGFA TGFBR1 NKX2-2 IL10RA FOXO1 IGF1R MOG TYK2 PDGFRA OLIG1 CX3CR1 OLIG2 SOCS3 TNF CCL1 MAPK14 CTLA4 NKX6-1 CCL20 IL33 CSPG4 ITGB3 CD80 HEXB IL10RB IL12A CD68 NFKB2 IFNG STAT5B ITGA2 JAK3 OSM IL2RA IL2RB CD44 IL2RG MYD88 TGFB1 STAT3 CXCL12 TGFBR3 STAT4 IL12RB1 IL10 CCR8 FOXP3 NFKB1 HTR7 IL2 IL4 IL6 SPP1 NOS2 SOX9 PDCD1 CDC42 SSTR2 FOXO3A FOXO4 ROS1 ITGAV IKZF2 IL18 AIF1 CCN3 NKX6-2 TNFRSF1B IL1B KLRG1 RAC1 APOD MCAM JAK1 GSDMD TMEM119 TGFBR2 CXCL1 AREG CCR6 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome CDKL5 KCNJ10 XAB2 MEF2C TBL1XR1 IMPDH2 CHD4 HAP1 SCN8A HTT ACTL6B BRAF CRK SCN1A GABBR2 SCN2A HDAC5 HDAC8 SYNE2 GNAO1 NCOR1 STXBP1 NCOR2 SRRM3 SMARCA4 TAF1B FOXG1 HDAC1 SHANK3 SMARCA1 SMC1A TBL1X GRIN2B TCF4 SYNGAP1 EIF2B2 GABRA3 KDM5B TRRAP GPS2 RHOBTB2 CECR2 HIVEP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MEF2C MIXL1 MESP1 THY1 NKX2-5 NCAM1 INHBA SIRPA IGF1 ZFP42 BMP4 POU5F1 ISL1 INS KDR PDGFRA PAX6 NRG1 GATA4 SOX1 SOX2 MAPK14 TBXT NOTCH1 BMP1 CXCR4 MESP2 FOXA2 IGF2 TBX20 IRX4 TBX5 KIT MYL2 WNT3A TNNI3 GSK3B SOX17 SCN5A TGFB1 LIN28A LIN28B ROR2 DKK1 NODAL FGF2 NOG MYH6 MYLK3 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade SERPINB2 F13B PLAT KLKB1 PLG FGA VWF F2 HEL-S-78p KLNA1 F7 SERPINF2 F3 F5 F10 F8 F11 F9 WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling CAMK2A CCND2 DAAM2 PRICKLE2 GPC4 CAMK2G CTBP2 NFATC3 NFATC2 NFATC4 INVS WIF1 CCND3 MAP3K7 CCND1 MAPK9 MAPK8 FZD10 ROR2 FRAT1 FRAT2 CSNK2A1 CSNK2A3 NFATC1 CSNK2A2 CSNK1E DKK1 DKK2 DKK4 SFRP4 CSNK2B PPP3R1 PPP3R2 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 PPP3CA RAC1 PPP3CC PLCB4 PLCB1 PLCB2 DAAM1 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CHD8 RYK ROR1 WNT5B SOST LEF1 NKD1 NKD2 PRKCB DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 WNT3A VANGL1 KREMEN1 SENP2 SFRP5 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 ROCK2 JUN WNT16 NLK LRP5 LRP6 ARHA APC CTBP1 PLCB3 CAMK2D ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling CPT2 ME1 RXRB CD36 RXRG FABP4 DBI PLIN1 NR1C1 PDPK1 ANGPTL4 UCP1 RXRA APOA5 OLR1 APOC3 FADS2 SCD CYP7A1 APOA2 CYP27A1 PCK1 HEL-S-28 CYP8B1 PLTP FABP1 PPARG SLC27A5 LPL SLC27A1 EHHADH CPT1C NR1C2 UBC NR1H3 SLC27A4 CYP4A11 PCK2 ACSL1 ACOX1 AQP7 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling CAMK2A EGFR PAK1 NRG4 NRAS BRAF CAMK2G FOXO1 SRC SHC1 PDPK1 MYC AKT3 NRG1 HBEGF ERBB2 MAP2K4 NRG2 EIF4EBP1 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC4 SHC2 MAP2K1 SHC3 MAP2K2 TGFA BCL2L11 ERBB3 EGF RAF1 RPS6KB2 CDKN1B RPS6KB1 PRKCB PRKCA PIK3R3 PAK6 PAK4 STAT5B CCND1 GSK3B PIK3CD MAPK10 MAPK9 MAPK8 ARAF PLCG2 CRK JUN PIK3CA NRG3 CRKL BAD MTOR PIK3R2 PIK3R1 MDM2 CBL EREG BTC NCK2 NCK1 CDKN1A ABL2 HRAS CAMK2D GRB2 AREG SOS1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNT1 ACTA2 MYL3 TNNT3 MYH8 HEL113 MYL1 MYOM1 MYBPC3 TNNC1 TNNI1 ACTN2 DMD HEL-S-273 HEL-S-108 ACTN4 TTN ACTG1 tmp_locus_29 TPM3 TPM1 TMOD1 TCAP MYH6 ACTA1 MYL4 TNNI2 MYL2 TNNI3 TNNC2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 OXCT1 ACAT1 UCP2 BDH1 SLC25A20 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 SRD5A2 POR AKR1D1 AKR1C4 HSD3B1 SULT2A1 HSD17B3 CYP17A1 HSD17B2 AKR1C1 CYP3A7 AKR1C2 CYP3A4 HSD17B4 HSD17B1 HSD3B2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology HEL-S-15 ADCY3 ADCY1 SMAD2 ADCY8 SMAD4 ADCY6 WWTR1 TGFB1 LBR NRAS SYNE4 CTGF SYNE3 SUN1 YY1AP1 PLEC HEL-S-7a SYNE2 MAPK1 SYNE1 ARHA KRAS SOS2 MAPK3 TMEM43 HEL-S-61 MAP2K1 MAP2K2 BANF1 EMD ADCY9 LEMD3 HRAS GRB2 SOS1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m ERN1 ASNS NFE2L2 DNAJB11 BBC3 XBP1 SULT1E1 HEL-S-89n EIF2A EDEM1 HEL-S-99n DNAJC3 ERP27 TRIB3 DDIT3 DNAJB9 UBE2E1 PPP1R15A BCL2L11 NARS1 ATF3 ATF4 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL SMAD2 PARP1 SMAD4 TGFB1 PPARG FBN1 ZMPSTE24 FNTA BANF1 LMNA INS KCNJ6 MUCL3 SPRTN ICMT LMNB2 WRN FFAR3 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1A2 CAMK2A NPPB CASP9 PDE3A RELA PBR GUCY1B1 CAMK2G GRIN1 NFKB1 CNGB1 ACTN2 DLG4 CNGA3 CNGA4 AKAP9 TNF CNGB3 NEFL NOS2 PDE2A BAD NFKBIA CALM1 BCL2 NPPA GRIN2B IFNG CREB1 IL1B CNGA1 CAMK2D CYCS AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG2 PRKAG3 PRKAA1 SIRT1 PRKAB2 RPS6KB1 PRKAB1 PRKAA2 PMAIP1 PPARGC1A MAPK3 RPTOR HEL-S-32 MTOR PARP2 PRKAG1 MLST8 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA ACTA2 SMAD2 CASP9 SMAD4 CASP3 BAK1 TGFB1 APAF1 TRPV5 BAX BRAF TGFBR1 PDE1B TNFRSF1A PIK3CA MAPK1 CASP8 SEC16B MAP3K5 HEL-S-41 MTOR FFAR3 PPP3R1 RAF1 TNFSF11 PTH MCU FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP9 MAPK8 PAK1 CASP3 APAF1 CASP10 FAF1 MAP3K1 JUN DFFB MAPKAPK3 DFFA FAS ARHGDIB LMNB2 MAP2K4 TNF CASP8 RIPK2 NFX1 SMIM40 PRKDC BCL2 FADD PARP1 ACTG1 SPTAN1 TNFSF6 CASP6 PS1TP5BP1 LMNA MAP3K7 ACTA1 RB1 HEL-S-102 MAPKAPK2 CYCS IL1A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network ADORA2B BTG2 AURKA PML ZMAT3 PERP LIF ISG15 FAS CX3CL1 TP53I3 CDK2 PRKAA2 TNF GPX1 CCL2 RPTOR SMR3B DEPTOR ACAD11 SERPINB5 PRKAG1 MLST8 SCO2 PRKAG2 ADGRB1 NOTCH1 DRAM1 RPRM SIVA1 MGMT ULBP2 PRKAG3 ULBP1 SESN2 PRKAA1 BBC3 TP53AIP1 IRF9 PIDD1 TNFSF6 DDIT4 SESN1 TIGAR FUCA1 PRKAB2 CPT1C PRKAB1 AKT1S1 SLC7A11 DDB2 RRM2B PMAIP1 TNFRSF10B TRAF4 CCNG1 POLK TSC2 XPC ERCC5 APAF1 BAX SFN MSH2 THBS1 FANCC ULK2 ULK1 MTOR GADD45A PCNA TNFRSF10D NCF2 CCNE1 E2F7 CDKN1A PTEN GLS2 TP53INP1 XRCC5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap MAT1A CDO1 ADK MTR CTH HEL-S-182mP HEL-S-61p CBS BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 SST FOXO1 SFRP1 DKFZp781O1323 CTNNB1 DKK1 WNT4 SMAD1 BMP2 DCN LEFTY2 BCL2L11 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CA HLA-DRB1 PIK3CD PIK3R3 CD80 PPP2CA PTPN11 CTLA4 PTPN6 PIK3R2 PIK3R1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT1 HEL-S-277 PRMT7 NOS2 CARM1 PRMT3 PRMT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 HGS RAF1 ARAF PDCD6IP BRAF NRAS RAB5B RAB5C RRAS2 RRAS MAPK1 KRAS RAB27A MAPK3 HRAS RAB5A IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BIRC5 TGFB1 RELA CHUK STAT1 STAT3 RUNX2 PIAS1 SRC TYK2 PDPK1 SOCS3 IL11 MAPK1 IL11RA BGLAP FYN MAPK3 ATF1 PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2 YES1 RAF1 FES RPS6 RPS6KA1 RPS6KB1 IBSP PTPA IKBKB CREB1 JAK1 HRAS ITGA2 GRB2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COX11 ERBB2 MAPK1 ADRA2B ARHA MAPK3 CIAO2A ANKRD23 SNRNP200 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 DUSP2 CNNM4 FER1L5 STARD7 SEMA4C ARID5A COL2A1 ASTL NEURL3 ZP2 KANSL3 PLXNB2 MMS19 IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling GSK3B SPRED1 STAT1 STAT3 JUN SHC1 IL2 IL5RA MAPK1 CSF2RB KRAS MAPK3 PTPN11 MAP2K1 LYN MAP2K2 PIK3R2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 RPS6KA1 RPS6KB1 GSK3A JAK1 STAT5B BTK GRB2 SOS1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP3 CARD9 CARD6 ACAP1 NLRP10 NOD2 CASP9 NLRP7 NLRP2 NLRP12 RELA CHUK IKBKG NLRP1 NAIP CASP8 DUOX2 CASP5 RIPK2 NFKBIA NDUFA13 PRDM1 AIM2 PYCARD COPS6 IL18 IKBKB IL1B RAC1 NOD1 NLRC4 MEFV AAMP CARD8 ERBIN LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PDE3B RELA SH2B1 STAT1 CISH FOXO1 SRC SHC1 SOCS2 SOCS3 IRS1 ERBB2 PRKAA2 EIF4EBP1 MAPK1 FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 MAP2K2 EIF4E SOCS7 ACACA RAF1 PRKAA1 RPS6 LEPR RPS6KB1 ACACB REL STAT5B CFL2 KHDRBS1 GSK3B LEP KPNA4 MAPK8 CHUK STAT3 PLCG2 IKBKG ROCK1 PLCG1 ROCK2 NFKB1 SP1 ARHA BAD MTOR PIK3R2 PIK3R1 CDC42 RPS6KA1 GSK3A PTEN IKBKB CREB1 RAC1 JAK1 HRAS GRB2 NCOA1 SOS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC1H1 DYNC2H1 DYNLRB2 IFT46 DYNLT1 IFT140 DYNC1LI2 IFT81 DNCL1 DYNLT3 IFT80 WDR35 IFT27 DYNLL2 IFT25 IFT43 DYNC1I1 DYNLT2B IFT22 DYNC1LI1 DYNC2I2 DYNC2LI1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine HEL-S-7a ADRB1 ADCY3 ADCY1 ADRB2 ADCY8 ADCY6 ADCY9 ADRA2C ADRA2B ADRA2A ADRA1D PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCC2 CYP24A1 ABCD2 CYP26A1 NR1C1 CYP27B1 CYP3A4 NR1I3 NR1i1 ABCG5 CYP7A1 ABCD3 NR1i2 NR1H4 CYP8B1 RARA CYP2C9 PPARG ABCB4 CYP2B6 CYP1A2 ABCB1 ABCA1 CYP2E1 ABCC3 CYP4B1 NR1C2 ABCG1 ABCB11 NR1B3 NR1H3 CYP4A11 RARB HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA2 PDHA1 ACACA NFE2L2 PRKAA1 RPS6 VEGFA PRKAB1 ACACB EGLN1 HIF1A HEL-S-133P SLC11A2 PRKAG1 KEAP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 AKR1D1 AKR1C1 AKR1C4 AKR1C2 CYP3A4 CYP11B2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTC4S DECR2 ALOX5 ABCC1 ALOX5AP PTGR1 DECR1 CYP4F3 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX VLDLR NDEL1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP HIST1H2BE CDKN2A FZR1 RPS6KA2 RELA CEBPB UBE2D1 EHMT1 CDK4 RPS6KA3 CDK2 MAPK1 MAPK3 H2BC21 H2AX CDKN1B UBB ANAPC1 CCNA2 RPS27A CDKN2D CDKN2B CDKN2C H3C8 CDC26 STAT3 VENTX ANAPC15 C10orf104 UBE2S CDC27 JUN UBE2C MAPK7 NFKB1 H3C15 IL6 CXCL8 CDK6 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 RPS6KA1 H2BC8 CDC23 H4C9 H2AC6 HIST1H4L ANAPC7 FOS H2BC3 ANAPC5 UBC H2BC1 CDKN1A ANAPC2 H2BC17 H3F3B H2BC12 ANAPC11 H2BC13 H2AJ H2BC14 UBE2E1 H2BC15 IGFBP7 H2AC20 H2BC11 IL1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways NADSYN1 TDO2 NMNAT1 IDO1 PARP4 PARP1 NAPRT NAMPT BST1 SIRT1 SIRT3 TNKS2 SIRT6 SIRT4 HEL-S-90n SIRT5 SIRT7 TNKS PARP2 SIRT2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HEXA HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB GLB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases MMP16 MMP9 MMP15 MMP23B MMP17 MMP19 TCF20 MMP26 TNF TIMP4 TIMP3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 hEMMPRIN MMP7 MMP2 MMP3 MMP10 MMP12 MMP11 TIMP1 MMP14 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 SMAD4 BMP6 RUNX2 IGF1 BMP4 DKFZp781O1323 BHLHE41 HMGB1 CSF1 PRKAA2 CTF1 LAMP2 NOTCH1 BCL2 CRY1 ATG3 BMP5 SP7 SOST ATG12 PTH TNFRSF11B CTSK ATG16L1 ATG101 PLEKHM1 CTHRC1 MAP1LC3A SQSTM1 ATG10 BMP2 PER1 CALCA LEP DKFZp762B153 RB1CC1 TGFB1 TRAF6 WNT16 VCP RORB NFATC1 BMP3 ATG5 DKK1 IL6 LRP5 AMBRA1 ARHGAP4 FYCO1 DRAM2 SMAD1 SEMA4D ULK1 MTOR IL3 SEMA3A SMAD9 TNFSF11 WNT10B EFNB2 BHLHB2 TNFRSF11A NPAS2 BMPR2 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity PCNA KDR BDKRB2 CYP3A4 MAPK1 PTK2B HEL-S-44 MAP2K1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 ABCC2 CYP2C9 UGT1A3 CYP2A6 CYP2B6 SULT2A1 DNAJC7 UGT1A1 ABCB1 UGT1A9 FOXO1 ABCC3 SRC SLCO1B1 UGT1A4 CYP2C19 CYP3A7 CYP3A4 RXRA PPARGC1A SRPX2 CYP4F12 NCOA1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKD3 ADCY3 ADCY1 PDE4A ADCY8 ADCY6 GNA14 GNG3 GNG5 GNG4 NRAS GNG7 GNG8 PDE1C AKAP5 PDE1B AKAP10 PDE1A PDE8A AKAP9 KRAS PDE7B PDE7A GNAZ PRKACG PRKCH PRKCB GNG10 GNA11 PRKCE GNGT2 PRKCA ADCY9 PRKAR1B GNAL PRKAR1A PRKCI PRKCQ PRKD1 PRKCZ GNAI1 GNAI3 GNG12 GNG11 GNG13 KCNJ3 GNA15 RRAS GNB2 ARHA GNB1 GNAS HEL159 GNB3 AKAP12 GNAO1 AKAP11 GNB5 AKAP7 AKAP6 CALM1 AKAP4 GNGT1 PDE4B PDE4D ARHGEF1 AKAP8 GNA13 PLCB3 PPP3CA PPP3CC HRAS ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling CHEK1 RAD9A MAPK9 TP73 MRE11A MDC1 IKBKG JUN CASP2 RAD50 TP53BP1 RAD51 CDK2 CRADD ATF2 GADD45A MDM4 H2AX PIDD1 MDM2 CCNE1 ATM TLK1 NBN RIPK1 SMC1A CDKN1A BRCA1 CCNB1 CREB1 CDC2 CHEK2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 FADD CASP9 CASP3 APAF1 TNFSF6 CASP6 MAP3K1 TNFRSF1A CASP2 RIPK1 NFKB1 FAS CASP8 AIFM1 CYCS PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC35B2 CANT1 BPNT2 PAPSS2 CHST3 XYLT2 XYLT1 CHSY1 CSGALNACT1 B3GAT3 SLC26A2 B3GALT6 EXT2 CHST14 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP1 AXIN1 TNK2 TNK1 BTRC SKP1 DVL1 CTNNB1 DVL2 RBX1 DVL3 PARP10 APC PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection HLA-DQA2 HLA-DQA1 HEL113 STAT1 VEGFA HLA-DRB1 FAS PDGFRA HLA-B HLA-F CCL19 HLA-G TNF HLA-DOA HLA-E HLA-DRA HLA-DOB CTLA4 AGTR1 HLA-DPA1 HLA-DQB1 CCL21 HLA-DMB C1QB HLA-DPB1 C1QA CD40 LRRK2 TNFSF6 CD80 C4B_2 C2 C4A C8A IL12B IL12A CXCR5 HEL-S-62p CD40LG IFNG GDNF HARS1 IL17A IL2RA C1QC IF2B1 HLA-DRB5 CASP9 PRKCZ IL-21 CASP3 TGFB1 HLA-DMA CXCL12 PRF1 IL10 IL13 CSNK2A2 FOXP3 HLA-A IL2 IL4 IL5 TUBA1B CXCL8 C6 C7 CASP8 HLA-C C9 CD55 GNLY BHMT2 PECR ABCB1 GABPA IL1B MICA CXCL9 CXCL13 CXCL11 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome SNRPN NUP133 CDKN2A CCND2 PCM1 NUP98 RAE1 BDNF INS CDK4 DLX5 HEL-S-71 MSX1 HERC2 EIF4E TACR3 POM121 RNF8 PCSK1 RB1 CDKN2B CDKN2C CCND1 GHRH BBS4 GHRL PRKCZ AHCTF1 KISS1 UBE3A TUBGCP5 NIPA1 NDN TUBGCP6 TUBGCP4 NIPA2 FSHB GABRG2 SNURF ATP10A NUP85 TPR LHB CGA NUP107 CDK6 MDM4 POMC OXT NUP62 GNRH1 NUP188 NPAP1 NUP214 NDC1 MAGEL2 MDM2 GOLGA8S NUP88 GABRB3 NUP210 CYFIP1 GOLGA6L2 GABRR3 NUP93 FEZ1 FMR1 GABRR1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 GABRA5 NGF SEH1L AAAS GABRG3 NUP160 GABRG1 NHLH2 NUP42 RANBP2 NUP155 CDC6 NUP153 TYR NUP35 MKRN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway COL1A1 LAMA5 LAMB2 COL3A1 IL2RG ZAP70 TNFRSF1A THBS1 IL2 IL4 VTN IL5 IL5RA COL1A2 LAMB1 CD40 CD80 LAMC2 LAMC1 CD40LG IFNG TNFRSF1B LCK THBS3 IL2RA IL2RB GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG8 ALG9 ALG2 TUSC3 ALG14 ALG13 ALG3 B4GALT1 ALG12 ALG11 DPM3 DPM2 GCS1 DPM1 MAGT1 ALG1 ALG6 MGAT2 SRD5A3 DOLK DPAGT1 MPDU1 GMPPB CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CALM1 ATP2A1 HDAC2 CD8B1 MEF2D EP300 HDAC1 CD8A CABIN1 PLCG1 ZAP70 PPP3CA PPP3CC NFATC2 LCK ITPRIP RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway RS1 ANGPT4 BIRC5 ANGPT2 TNIP2 ITGB1 TNIP3 EGFR ANGPT1 PAK1 RELA NRAS GRB7 FOXO1 SRC RAD51 CTNNB1 MYC ERBB2 EIF4EBP1 MAPK1 MAPK12 KRAS MAPK3 MAPK13 PTPN11 MAPK11 MAPK14 NFKBIA GRB14 PXN STAT5B CASP9 MAPK9 MAPK8 CHUK STAT3 BAX YAP1 CRK IKBKG MSH2 PIK3CA NFKB1 NOS2 BAD PIK3R1 NCK1 IKBKB MMP2 RAC1 HRAS GRB2 SOS1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 NOP2 CDKN1B FLT1 FOXO3A GAB2 ABCB1 LYL1 SKP2 PDGFRA CSF1R MYC ABCG2 KIT BCR GADD45A CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EGFR CREBBP KDM5C EFCAB3 FLT1 PBRM1 EP300 SDSL PGBD5 LDHD VEGFA PSAT1 CAMK1 PSPH ENO1 KDR KSR1 HEL-S-68p SETD2 BHLHE41 PDGFRA HEL-S-30 SSPN RPTOR PHGDH DEPTOR MLST8 ACACA FASN HEL-S-51e GRB10 RHEB BAP1 AKT1S1 LDHB SQSTM1 ACACB HIF1A HEL-S-133P HK3 HEL-S-32 CEP290 KCNJ2 ME1 PGM2 MAP2K5 TSC2 TSC1 STAT3 HEL-S-162eP PFKL ACLY ENO2 PFKM ENO3 PLOD2 PFKP HEL-S-49 HEL-S-87p ENPP3 HK2 VHL MTOR RAPGEF5 PKLR ALDOB SHMT1 PTEN HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 FGF20 THEM4 ATP6V1H MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 MAPK3 PTPN1 INSR PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 KLB FLT3 IRS1 PDE3B IRS2 PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 PTPRF FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 TRIB3 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 ABCA3 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2C GRIN2B NRGN GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer MAPK1 PIK3CB PIK3R2 PIK3R1 PIK3CA MAPK3 CLIP1 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC25A15 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 DEFB4B S100A8 LTF TLR2 S100A7 DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation PLK1 TCF7L2 CCNB1 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B TBX2 HINT1 CCND1 SIN3A CDK2 CTNNB1 MET RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 ATF5 ATF3 ATF4 GRB10 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements YWHAB HSPB1 ELAVL1 PSMD8 PSMD6 ZFP36 PSMD7 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 CCNB2 NEK9 CCNB1 NEK6 NEK7 CDK1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle HNRNPC CCT7 RBMX DBN1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA UBC ZBP1 TREX1 RPS27A DDX41 DTX4 TBK1 IRF3 STING1 NLRP4 UBA52 TRIM32 TRIM21 TRIM56 UBB CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG4 GUSB ARSB IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 CDKN1A DEK FLI1 KLF5 H2AC20 LEF1 CDK2 CEBPB MYC E2F1 TFDP1 TFDP2 CDK4 H2AX CSF3R SPI1 GFI1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TAL1 H2BC11 RARA CEBPA KMT2A CBFB CEBPE GATA2 H3C15 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling RXRA SCD FASN CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 FABP6 EP300 APOC2 APOC1 AGO1 ANGPTL3 AGO2 PLIN1 TNRC6A ABCG1 TNRC6B BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SRD5A3 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage XIAP CYCS CASP9 CASP7 APAF1 CASP3 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 CCNE1 STAT3 HDAC3 GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 RAC1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 ACTB CLIP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS GLUD1 GLUD2 KYAT1 RIMKLA GLUL RIMKLB PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 PLCG1 FGF20 FGF16 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development DLL1 POU3F3 WNT4 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling NTRK3 NTF3 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 YWHAB RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB RAPGEF3 SIPA1 RAPGEF4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide CA4 CA7 CA6 CA9 CA14 CA13 CA12 CA1 CA3 CA5B CA2 CA5A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 DICER1 TARBP2 TSN AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HBEGF EGFR HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia ARG1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CCT6A HSP90AA1 CDC37 HSP90AB1 RNF20 TWF1 SPEN MSI2 CCT2 RHOBTB2 CPSF7 ROCK1 ACTN1 ROCK2 TMOD3 GPS1 DDX39B CUL3 PHIP TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 ACTG1 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS1 GINS2 CDC45 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA AKT2 STRADB TSC2 TSC1 PRKAB1 YWHAB RPS6 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 AKT1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle TIAM1 ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 PIK3R2 NOXA1 PIK3R1 ABI1 NOX3 ESYT1 FERMT2 NOX1 ABR MCF2 CDC42 LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SRGAP2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 DIAPH3 ITGB1 GIT2 VAV2 CAV1 MCAM LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR2 TGFB1 TGFBR1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 HMGA1 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 TP53 H1-5 H1-4 HIRA UBN1 EP400 ASF1A INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway IL36B IL36G IL36RN IL1F10 IL1RL2 IL36A DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions DSCAM DCC DSCAML1 NTN1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle ARHGAP26 BAIAP2 VANGL1 ARHGAP32 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 DAAM1 CDC42EP3 TRIO CDC42EP2 RASGRF2 WAS ITSN1 PARD6A PLEKHG4B CHN1 PAK6 PREX1 STOM MCF2L PAK3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 CDC42BPB SRGAP2 ARHGEF10 CDC42BPA ARHGEF12 DEF6 PLEKHG2 KTN1 ARHGEF15 SHKBP1 DLC1 ARHGEF16 ARHGEF19 DIAPH3 VAV2 TIAM1 ARHGEF9 ARHGEF4 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF ARHGEF6 ARHGEF26 FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 MCF2 CDC42 FMNL3 FMNL1 FMNL2 LAMTOR1 TFRC SNAP23 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 SYDE1 ARHGAP42 OPHN1 ARHGDIB LBR GIT1 TMPO ARAP2 ARAP3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A ARHGAP17 ARHGAP21 PAK1 RACGAP1 PAK2 YKT6 PAK4 GIT2 CAV1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 NCAM1 ITGA5 ITGA9 EGFR CSNK2A1 CSNK2A2 PAK1 MAPK1 RAC1 CSNK2B NRP1 MAP2K1 MAP2K2 MAPK3 ITGB3 ITGB1 ITGA2B L1CAM VAV2 ITGAV MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal MGMT MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBC RPS27A UBA52 UBB ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans NCAM1 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TGFB1 TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 TNXB LRP4 ACAN TGFB2 LUM TGFB3 DSPP COL9A1 COL9A3 COL9A2 AGRN FMOD NCAN BGN DCN BCAN VCAN LAMA5 LAMA2 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN DAG1 ITGB3 ITGB1 ITGA2B ITGAV SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins H4C9 HDAC1 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I HDAC4 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 NUP205 CBX5 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis GCKR GCK PPP2R5D PRKACG PRKACA PRKACB PPP2CA PPP2CB HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 NUP37 PGK2 PFKL GNPDA1 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1 SUMO3 SUMO2 UBE2I SUMO1 RWDD3 UBA2 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes CREBBP SP1 BCL2 PDGFA MAFK AREG EGF NFE2L2 BCL2L1 EP300 NOTCH1 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN6 TNFRSF14 PTPN11 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR3 TAC3 TACR1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K NTF4 NTRK2 BDNF GAB1 PIK3R1 PIK3CA ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism GPT ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 HBEGF AREG EGF EGFR AKT2 CDKN1B MAPK1 CCND1 TGFA XPO1 FOS FOXO3 ELK1 SRF PTK2 AKT1 EREG MAPK3 UHMK1 BTC EPGN AKT3 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway ADCY5 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis GNG13 GNB2 PPP2R5B GNB1 PPP2R5A PPP2R5D PPP2R5C GNB4 GNB3 GNB5 GNGT1 GUCY1B2 GNGT2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PDE5A PLA2G4A PTPN11 FGR STIM1 KCNMA1 PPP2CA ORAI2 PPP2CB PECAM1 ORAI1 PDE9A PDE1B GNG3 PDE1A ITPR1 ITPR2 GNG2 ITPR3 GNG5 SRI GNG4 LRP8 GNG7 PDE11A KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 APOB TRPC7 NOS2 NOS3 PDE2A TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 PDE10A P2RX3 P2RX2 P2RX1 GNAS PPP2R1B PPP2R1A PTPN6 MAPK14 GNG10 GNG12 PPP2R5E GNG11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TRMT5 TYW2 TYW1 LCMT2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization CIDEC HILPDA CIDEA FITM1 HSD17B13 FITM2 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation UBC RPS27A RAB7A KPNA1 UBA52 ATP6V1H NOS2 VPS33B CORO1A HGS RAB5A KPNB1 UBB VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity UBC MAFK SKP2 RPS27A SKP1 RBX1 UBA52 FBXL17 BACH1 UBB CUL1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis OMA1 OPA1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ARHGAP10 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPK1 MAPK3 PPP2R1B PPP2R1A MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB ST6GALNAC3 MAN2A1 MGAT5 ST6GALNAC4 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC ST3GAL4 MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 ST6GAL1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors PTGDR PTGER4 PTGFR PTGER1 PTGIR TBXA2R PTGDR2 PTGER2 PTGER3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination HGS MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 TRIM25 NFRKB PSMD1 USP17L30 HIF1A YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 BRCC3 PSMA1 SNX3 RHOT1 PSMA2 RCE1 ZRANB1 UBA52 SIAH2 INO80 STAM PSMD12 TADA2B PSMD11 CYLD H2AC25 PSMD14 H2AC21 BAP1 PSMD13 WDR48 OTUD7A PSMA7 OTUD7B BABAM1 PSMB6 IFIH1 BABAM2 PSMB7 UCHL1 TRIM4 PSMB4 UIMC1 UFD1 PSMB5 ACTB IKBKG TOMM70 UBB RIPK2 PSMB2 ACTL6A PSMB3 JOSD2 UCHL3 UBC JOSD1 PSMB1 UCHL5 DDB2 RPS27A KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 RNF135 PSMC6 STAMBPL1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 MBD5 PSMC2 USP17L18 MBD6 USP17L17 TP53 USP9X USP17L19 MCRS1 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 IL33 USP3 USP2 MUL1 TGFB1 H2AC1 TGFBR1 CDC25A TGFBR2 FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 ABRAXAS1 SKP2 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B CDC20 NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 EP300 ASXL1 TNIP1 TNIP2 TNIP3 H2AC8 ASXL2 H2AC6 OTUD3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RHOA KDM1B AXIN1 APC UBE2D1 CDK1 BRCA1 BARD1 SEM1 CCNA2 CCNA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations POMK DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism GAMT GATM SLC6A7 SLC6A8 CKM CKMT1B SLC6A11 CKB SLC6A12 CKMT2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B EIF4E NUP214 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 UBB UBC RPS27A HSPA8 XRN2 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35C1 PDZD11 SLC25A5 APOD SLC25A4 SLC25A6 SLC35B3 LCN9 SLC35B2 SLC27A1 SLC35B4 SLC35D1 SLC35D2 LCN15 LCN12 SLC35A2 SLC35A3 SLC33A1 SLC5A6 ARL2BP LCN1 SLC29A4 SLC27A6 SLC28A2 SLC35A1 SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC27A4 ARL2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D CHRM2 HTR1A CHRM3 TAAR5 CHRM1 HTR1B CHRM4 TAAR2 CHRM5 ADRA2C HTR5A ADRA2B TAAR1 ADRA2A ADRB2 GPR143 ADRB3 HTR2B HTR2C ADRB1 ADRA1D HTR2A ADRA1B HTR4 ADRA1A HRH1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 INS MAPK1 MAPK3 PTPN1 PTPN11 SNW1 CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51D RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A YBX1 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 FGF16 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases LCK FYN FLT3LG FLT3 HCK SYK GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 F9 PROC F10 GGCX PROS1 FURIN PROZ F2 BGLAP GAS6 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA BCKDHB DBT DLD LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG LDLRAP1 AP2M1 CUBN CETP AMN ZDHHC8 APOA2 APOA1 LSR APOA4 PRKACG APOA5 NPC1 PRKACA SOAT1 PRKACB SOAT2 NPC2 APOE ANGPTL8 ANGPTL4 LPA CES3 ABCA1 SAR1B MTTP MYLIP LPL LMF2 LMF1 NR1H2 APOF APOC4 AP2S1 NR1H3 A2M LDLR GPIHBP1 FGF21 MBTPS1 APOBR APOC3 APOC2 AP2B1 APOC1 ANGPTL3 NCEH1 ALB ABCG1 P4HB MBTPS2 APOB UBA52 UBB UBC RPS27A VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 FLAD1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP1 MIP AQP11 AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions VASP FBLIM1 PXN TESK1 ILK PARVA PARVB FLNA FLNC ARHGEF6 RSU1 FERMT2 LIMS2 LIMS1 ACTN1 ITGB1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 ITCH PSMD14 SUFU BTRC PSMD13 NUMB PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP ELAC2 TRNT1 HSD17B10 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB ADCY1 ADCY8 CALM1 PRKAR1B PRKAR2B DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a MGAT2 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway FZD2 GNG13 FZD5 WNT5A FZD4 GNB2 PDE6G FZD6 GNB1 NFATC1 GNAO1 MAP3K7 GNB4 TCF7L2 GNB3 TCF7L1 GNB5 LEF1 GNGT1 TCF7 GNGT2 CTNNB1 PRKG2 TNRC6C MOV10 GNG3 AGO3 ITPR1 AGO4 ITPR2 GNG2 ITPR3 GNG5 GNG4 AGO1 GNG7 AGO2 TNRC6A GNG8 TNRC6B CAMK2A CALM1 PRKCA PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 GNG10 NLK PPP3R1 WNT11 PDE6B PDE6A GNG12 FZD3 GNG11 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing CPSF4 CPSF1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TYW5 NUP43 TYW3 RAE1 TRMT5 TYW2 NDC1 TYW1 RANBP2 SEC13 LCMT2 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TRMT10C PRORP ELAC2 TRNT1 HSD17B10 TP53RK CLP1 POP5 POP7 OSGEPL1 POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 RPP38 PUS3 METTL1 CSTF2 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU QNG1 TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 TSEN34 URM1 LAGE3 RPP14 TRDMT1 RTRAF TRMT10A ADAT1 NUP214 TPRKB TRMT1 ADAT3 TRIT1 ADAT2 XPOT TRMT6 FAM98B TRMT61A TRMT61B RAN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS HRAS SOS1 NTRK3 NTF3 NRAS ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 ATP2A3 SLC9B2 RAF1 ATP2A2 SCNN1G ATP2A1 SCNN1D SCNN1B SCNN1A ATP7A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPM1 ATP4B SRI TRPM2 ATP4A TRPM7 FXYD4 TRPM8 FXYD3 TRPM5 WNK1 TRPM6 FXYD2 TRPM3 WNK2 TRPM4 FXYD1 WNK3 TRPC7 FXYD7 TRPC5 FXYD6 MCOLN3 CUTC TRPC6 ATP2B4 RYR1 TRPA1 ATP2B3 RYR2 TRPC3 ATP2B2 RYR3 TRPC4 ATP2B1 UNC80 TRPC1 TRPV2 ATP7B TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN PDZD11 ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 TCIRG1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 ATP6V1E1 STOM ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 NEDD4L ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 SGK1 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 CAMK2B CAMK2D CAMK2A CALM1 CAMK2G UBA52 WWP1 UBB UBC RPS27A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBC RPS27A SMURF1 PARD6A CGN UBA52 F11R PRKCZ TGFB1 RHOA PARD3 TGFBR1 TGFBR2 FKBP1A ARHGEF18 UBB CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division PLK1 KIF23 PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 KIF20A ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling NRG1 PTK6 HBEGF EGF ERBB2 EGFR NRG3 EREG NRG4 BTC NRG2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism MOGAT3 MOGAT2 GPAM MOGAT1 PPP1CA ABHD5 FABP12 PRKACG GK3 GK2 PRKACA LIPE PRKACB AGMO GPAT2 DGAT2 GK DGAT1 PPP1CB FABP9 PPP1CC FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 FABP6 LPIN2 MGLL LPIN3 PLIN1 CAV1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP CITED1 CITED2 YEATS4 CITED4 TFAP2A TFAP2B WWOX EP300 TFAP2C TFAP2D TFAP2E ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP GPAM ERCC6 ANGPTL4 LPL RBM7 DPY30 CHD4 TBP EED SAP18 MTA2 CIDEC MTA1 MTA3 MED1 MORC2 ACSL1 ELOVL5 MED4 MED6 MED7 SCD ZNF141 HDAC1 ZNF382 SETD1B SETD1A SIN3A ZNF136 EHMT2 EHMT1 PHF20 ASH2L UBE2I ZNF28 AJUBA ZNF273 HCFC1 CCNH PPARGC1A PPARGC1B POLR2E ZNF264 POLR2F POLR2H POLR2K POLR2L GTF2H1 ZNF30 GTF2H2 ZNF257 GTF2H3 EZH2 GTF2H4 ZNF33A GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB ZNF331 MED16 ACTL6A MED17 MED12 MED14 MED13 KAT2B KAT2A MED10 ZNF324 MEN1 ZNF320 MED27 SIRT1 ZNF317 MED23 MCRS1 MED24 MED20 ABL1 ZNF547 ZNF224 MBD3 GATAD2B GATAD2A SUDS3 CDK8 CDK5 ZNF778 TADA3 ZNF454 OGT SIN3B WDR5 PSIP1 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 RB1 RBBP4 RBBP5 RBBP7 SMARCE1 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 CEBPA KMT2A H3C15 TDG RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 DEK H2AC20 ZNF418 HDAC3 GPS2 LIPE TBL1X ZNF354A DGAT2 NCOA1 ZNF649 FABP4 NCOR2 NCOR1 CHD3 TBL1XR1 LPIN1 MGLL CBX3 SUMO2 RRP8 SAP130 PLIN1 DPF1 HDAC2 PDK4 DPF2 KAT8 DPF3 SAP30BP HCFC2 SUZ12 WDR82 PAXIP1 PEX11A BAZ2A CBX5 KAT14 SETDB1 SS18L1 SMARCA5 ZZZ3 ARID1A TADA2A GSK3B ARID1B ZNF816 EZH1 PHF1 SUV39H1 SGF29 CD36 JARID2 NCOA2 ZNF610 SS18 NCOA6 SMARCB1 NCOA3 CCNC TET2 TET1 SF3B1 PPHLN1 BAZ1B TRIM28 PHF20L1 NR5A2 AEBP2 MTF2 TET3 PLIN4 PLIN2 MBD2 SMARCC1 MYBBP1A SMARCC2 MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 MTREX TASOR MBIP ZNF708 TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C SMARCA2 BCL7B SMARCA4 DNMT3B UBTF ZNF765 KDM6A DNMT3A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes PPARGC1A GCK FBXO32 G6PC1 CAT INS ABCA6 HDAC1 RETN POMC NPY SIN3A SOD2 PLXNA4 PCK1 NR3C1 FOXO4 ATXN3 TRIM63 SMAD2 SMAD4 AGRP SMAD3 FOXO6 FOXO1 HDAC2 IGFBP1 SIRT3 FOXO3 SREBF1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB AKT2 TSC2 TSC1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 HEXB ARSG HEXA ARSD B3GALNT1 GLB1L3 B3GALT4 M6PR GLB1L2 GALC GLA GLB1L GLB1 ARSB ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein PARP10 PARP6 GSK3A UBE2I PARP4 PARP16 GSK3B SUMO1 PARP9 PARP14 PARP8 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation NTRK1 KIDINS220 RAP1A CRK NGF BRAF YWHAB DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU FMO3 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death ITCH YWHAE YWHAQ YWHAG YWHAH UBE2L3 TNFSF10 UNC5A DAPK1 UNC5B DAPK2 DAPK3 FADD ELANE CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 APPL1 DFFB DFFA DBNL RIPK3 IL18 ACIN1 IL1A IL1B KPNB1 GAS2 PELI1 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 TICAM1 CHMP4C PKP1 CHMP4B CHMP4A LY96 SDCBP BMF MLKL BMX STK24 STK26 CHMP2B CHMP2A AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 CASP5 CASP4 PPP3R1 FLOT1 FLOT2 DNM1L DSP PDCD6IP OMA1 IRF1 OPA1 IRF2 DSG1 CHMP3 DSG3 CHMP6 CHMP7 PLEC UACA ADD1 BAK1 GZMB CDKN2A MAGED1 CTNNB1 MAPK8 BCL2L11 BAD CDH1 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 BBC3 UBC PSMB1 DSG2 RPS27A PRKN ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 PAK2 CASP9 CASP7 APAF1 DIABLO CASP3 XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC OGT TRAF2 HSP90AA1 KPNA1 CDC37 BIRC2 BIRC3 E2F1 TFDP1 TFDP2 ARHGAP10 AKT2 TP53BP2 OCLN TNFRSF10B TNFRSF10A STAT3 DYNLL1 DYNLL2 MAPK1 PPP1R13B TJP1 FAS FASLG MAPK3 PMAIP1 SATB1 CASP6 CASP1 APC STUB1 BAX TP63 BCL2 BCL2L1 SEM1 TP73 PTK2 AKT3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IFNG NFATC2 RUNX1 TNFRSF18 CTLA4 CBFB IL2RA FOXP3 IL2 CR1 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SRD5A3 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ST6GAL1 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 MVD ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1 AKT1 AKT2 AKT3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN NCSTN YWHAZ APH1B PSEN2 ADAM10 PSEN1 JAG1 APH1A DLL4 NOTCH4 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 AURKA PSMD14 PSMD13 PSMA7 PSMB6 FBXL18 FBXL7 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism HSPG2 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 IDUA EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 CTSL HPSE IDS THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOX1 TPO IYD DUOXA1 CGA DUOXA2 DUOX2 TSHB DIO1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 YAP1 TCF7L2 CDKN1A TCF7L1 SPP1 CDKN2A LEF1 TCF7 TGFB1 CCND1 MAMLD1 CTNNB1 BCL2L11 ITGAL RBPJ ITGA4 SMAD4 SMAD3 SMURF2 ZFHX3 SNW1 MYC SMURF1 HDAC4 TEAD1 SRC MDM2 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 BRD2 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 CCN2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 KRAS PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A KAT2B KAT2A EP300 JAG1 ADRM1 WWTR1 PSMC5 PSMC6 SEM1 PSMC3 RUNX1 PSMC4 PSMC1 RUNX3 PSMC2 TP53 MAML3 FOXO3 CBFB NOTCH1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions LCK FYN PECAM1 LYN INPP5D PTPN6 PLCG1 ITGB3 YES1 PTPN11 ITGAV LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants FLT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 ARHGEF6 BTK GNGT1 RHOA GNGT2 CDC42 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PAK1 PDPK1 PLCB3 PLCB1 GNG10 PLCB2 AKT1 GNG12 AKT3 GNG11 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 JAK2 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 P4HB PPIA SNRPA1 PAK2 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling CBL UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling PRKCA ADCY9 ADCY4 ADCY3 ADCY2 PLCG1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA CALM1 CAMK2G PRKCD DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets RPS6KA1 PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MEF2C MAPK7 MAPK14 MAPK11 MAPK1 ELK1 MAPK3 MEF2A RPS6KA3 RPS6KA5 PPP2R1B PPP2R1A RPS6KA2 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy PRKAG3 PLIN2 PLIN3 HSPA8 PRKAB2 PRKAA2 PRKAG1 PRKAB1 PRKAG2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions COL18A1 ITGA3 ITGB4 LAMA5 ITGA1 LAMA2 NID1 LAMB3 NID2 LAMC3 ITGA6 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 ITGA2 HSPG2 ITGA7 ITGB1 ITGAV BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism PDZD11 MCCC2 BTD SLC5A6 PC ACACA PCCA HLCS MCCC1 PCCB ACACB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 SEC11A SEC11C GATA4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events FOXM1 WEE1 LIN52 PLK1 CCNB1 EP300 CDC25C CENPF CDC25A RBBP4 CCNB2 LIN54 LIN37 MYBL2 LIN9 PKMYT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes H2BC9 H2AZ2 H4C9 PLK1 H2BC8 H2BC5 H2BC3 H3-4 CCNB1 H2BC1 H2AC20 RB1 CDK1 SET H2AX H2AB1 NCAPG2 H2AC19 SMC4 H2BC26 SMC2 H2AC14 H2BC12L NCAPH2 H2BC21 NCAPD3 MCPH1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT5A H3C15 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT6A STAT3 FBXL3 FBXL5 WRAP53 HDAC3 CCT2 KIF13A CCT3 SPHK1 SKIC2 CCNE2 TCP1 GBA1 CCNE1 DCAF7 CCT6B USP11 CCT7 FBXO4 AP3M1 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CCT8 CCT5 CCT4 FBXW2 NOP56 ARFGEF2 XRN2 GAPDHS FKBP9 TP53 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity PML TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 SRC TNRC6A TNRC6B CCND3 RUNX1 CCND2 CCND1 CDK6 CBFB PTPN11 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 CFTR STAM ACTB USP9X CCT6A TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 WWP2 WDR11 LETM1 TMEM59 VMA22 GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 ARMCX3 PKP4 RASAL2 STIP1 ACTG1 DDRGK1 PLXNA1 ANKRD26 NSFL1C CPD PLXNB1 ARHGAP11A ZNF512B CAPZB EFHD2 NCK2 DAAM1 WDR6 NCK1 DST PLEKHG6 NIPSNAP2 BLTP3B PARD6B SH3BP1 WHAMM WASF3 NDUFA5 PCDH7 SEMA4F SRGAP2 PTPN13 VAPB ATP6AP1 GOLGA3 CKB BAIAP2L2 KCTD13 FRS2 TMEM87A DIAPH1 GRB7 PIK3CA PIK3R3 SCFD1 DIAPH3 ITGB1 SPTBN1 CCDC88A ANLN FAF2 SOS1 KIF14 SH3RF1 NUDC AKAP12 HINT2 RAC2 MUC13 RHOG PIK3R2 RHOH PIK3R1 RHOF RHOC RHOJ RHOD RHOU RHOV RHOQ RHOA SAMM50 RHOB EMC3 MTX1 CAVIN1 MYO9A TRIP10 RTKN PRAG1 SYDE2 BASP1 ALDH3A2 ELMO2 DDX4 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 CDC42 PLD2 RHPN1 RHPN2 FAM83B ACBD5 MACO1 ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 DLG5 PICALM FMNL3 SRC DOCK5 DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 SOWAHC MTR TNFAIP1 RND2 RND3 RND1 CKAP4 SENP1 ZAP70 GFOD1 ALS2 PEAK1 NDUFS3 DOCK2 DOCK1 CCDC187 MOSPD2 FAM169A ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CSK FRS3 JAG1 LCK DBT CLTC HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 ARHGAP21 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 WAS PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 ARL13B RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 PRKCB CREBBP RUNX1 LGALS3 CBFB REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism WDR26 PDHB RMND5B LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GID4 GID8 UBC RPS27A PDK4 DLD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 CYP11B1 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC E2F1 RBBP4 E2F3 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PRKCB PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 PRKCA CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 PRKCG FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death JUN PRDX2 H2BC9 PRDX1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 CDC25B CDC25A LMNB1 BCL2L11 FASLG CDK5R1 RIPK1 CDK5 SUZ12 YWHAE TRAF2 EED CDC25C FADD GSDME C1QBP RBBP4 EZH2 GOLGA2 SOD2 CAPNS1 RIPK3 CAPNS2 CAPN2 RBBP7 CAPN1 CAST PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MLKL H2AC6 H2AC7 H2BC17 APP DNMT3B H2BC12 H2BC13 TRADD H2BC14 H2AJ DNMT3A H2BC15 TP53 CASP8 H2BC11 FOXO3 H3C15 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU PHB1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGF ERBB2 EGFR PLCG1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation FBLN5 LOXL1 ITGA5 LOXL2 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 FURIN MFAP5 BMP4 MFAP4 LOX MFAP3 MFAP2 FBN1 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization SGTA PEX10 PEX12 TOMM20 GFER GDAP1 PEX13 PEX14 OTC DHRS4 NUDT7 VAPA TOMM7 CRAT TOMM5 TOMM6 NOS2 STX5 CAT SLC25A4 SLC25A6 IDE PMPCB PMPCA SLC27A2 PECR SAMM50 ZFAND6 TOMM22 MTX1 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 SCP2 CHCHD7 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 CMC4 CMC2 PAM16 ECH1 PIPOX BCS1L GNPAT ACBD5 ACOT2 STX1A ACOT4 COX19 COX17 PEX11B ATP5MC1 TIMM50 BAG6 PITRM1 GRPEL1 ABCD3 GRPEL2 UBE2D2 LDHD UBE2D3 OTOF HMOX1 HACL1 HAO1 CYC1 DECR2 HAO2 DNAJC19 COA4 PRNP FIS1 EPHX2 IDH1 TYSND1 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 UBE2D1 AMACR DAO HSPD1 PXMP2 PXMP4 ACO2 ABCD2 UBA52 CROT HSCB SERP1 SEC61G TIMM17A TIMM17B GET1 SEC61B GET3 EMD ABCD1 COA6 GET4 CAMLG TIMM23 PEX2 TIMM22 HSPA9 PEX1 TIMM21 BAAT UBB TOMM70 PEX7 SLC25A17 ACOX2 ACOX1 UBC PEX3 EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PAOX NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 APP HSD17B4 TIMM10 DDO HMGCL ATP5F1A ATP5F1B USP9X UBL4A TIMM8B ATAD1 PEX16 TIMM8A PEX19 MTX2 IDH3G DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors F7 F9 PROC F10 GGCX PROS1 PROZ F2 BGLAP GAS6 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L PRKACA KIF7 PRKACB WDR35 IFT88 SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 GLI3 GLI2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 GNAS PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 BTRC NUMB PSMD13 OFD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PRKAR1B PSMC5 PRKAR2B PSMC6 PRKAR1A SEM1 PSMC3 PRKAR2A PSMC4 PSMC1 PSMC2 SKP1 CUL1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis AP2A1 AP2A2 AP2M1 ARF1 ATP6V1H CD4 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B HCK PACS1 ELMO1 RAC1 LCK CD28 FYN PAK2 DOCK2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction LCK RAC1 FYN PAK2 HCK DOCK2 ELMO1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 JUN PCNA COX5B COX5A PERP NPM1 COX6C TTC5 CCNG1 PRDM1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 NDRG1 HIGD1C CNOT10 CNOT11 TAF4B YWHAE PRR5 DYRK2 CHD4 TRIAP1 PIDD1 YWHAQ YWHAG ZNF385A YWHAH TBP TMEM219 TAF9 TAF1L AURKA MTA2 TAF15 TAF12 TAF13 TAF11 CARM1 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 PRDX2 PRDX1 PLK3 PRELID1 CDKN1A HDAC1 CDKN2A PLK2 CDK2 CDK12 CDK13 PRKAA1 PRKAA2 MDC1 ATF2 BTG2 MT-CO1 PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 RPTOR NOC2L CHM STK11 TNRC6C MOV10 MLST8 TAF7L SLC38A9 AGO3 ING5 AGO4 ING2 PRKAB2 PIP4P1 AIFM2 AGO1 TNKS1BP1 AGO2 TSC2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC MT-CO2 BRD1 MT-CO3 ELOB RHEB RRAGB ELOC RRAGD LAMTOR2 AKT1 MEAF6 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SFN BRD7 YWHAZ CCNH POLR2A POLR2B PRELID3A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K TIGAR POLR2L GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 POU4F2 SUPT5H HIPK2 GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB BBC3 UBC DDB2 RPS27A CASP10 CSNK2A1 MAPK14 MAPK11 CSNK2A2 CNOT6L TAF9B CSNK2B IGFBP3 KAT6A TP53 APAF1 CYCS USP7 PLAGL1 PMS2 USP2 RICTOR BID MBD3 MAP2K6 FANCI GATAD2B GATAD2A FANCC CNOT4 CNOT6 CNOT7 BCL6 CDK5 CNOT1 STEAP3 CNOT2 CNOT3 MDM2 MDM4 CNOT8 CNOT9 CCNT2 SESN3 PTEN SESN2 KMT5A GPX2 BNIP3L CDC25C RNF34 CDKN1B NLRC4 MSH2 E2F1 RBBP4 MAPKAPK5 DAXX TFDP1 RBBP7 CCNE2 TFDP2 RFFL CCNE1 PPP2R1B TXNRD1 PPP2R1A CPAP PML TAF10 TP53RK EP300 AKT2 TP53AIP1 CHEK2 SMYD2 COX7A2L PDPK1 TXN NUAK1 TP53BP2 BANP GADD45A BCL2L14 TPX2 ZNF420 BRPF1 BRPF3 TNFRSF10C TNFRSF10B PRMT5 TNFRSF10A PPP2R5C PRMT1 TNFRSF10D RGCC SGK1 PIN1 BIRC5 MLH1 PPP1R13B COX4I1 FAS COX4I2 PPP1R13L CDK5R1 AURKB PPP2CA PPP2CB FANCD2 COXFA4 RABGGTB COX7A2 RABGGTA COX7A1 CHD3 RRM2B PMAIP1 TP53INP1 HDAC2 TP53I3 E2F4 JMY E2F7 E2F8 CASP6 CASP1 CASP2 RBL2 RBL1 GPI CCNK CCNB1 GLS2 GLS CDK1 ARID3A BAX BLM TP63 MRE11 BRCA1 CTDP1 ELL WRN BRIP1 CCNT1 KAT5 SUPT4H1 ELOA EXO1 CHEK1 NELFB NELFCD RBBP8 NELFA NBN NELFE TOPBP1 L3MBTL1 ATRIP SUPT16H BARD1 CREBBP RFC5 RMI2 ELOA2 RFC3 SSRP1 CDK9 RFC4 RMI1 TCEA1 PCBP4 RFC2 TOP3A RPA1 HUS1 RPA2 CRADD RAD50 RAD51D TP73 COX7B RPA3 RAD17 FOS RAD1 CCNA2 ATM CCNA1 DNA2 COX7C RAD9B RHNO1 ATR COX8A RAD9A COX8C AKT3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D KIF17 GRIN1 RPS6KA6 DLG1 CASK GRIN2A LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIA3 CALM1 CAMK2G GRIA4 GRIN3B GRIN3A APBA1 CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 NBEA RPS6KA3 RPS6KA2 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity USP7 USP2 RICTOR TTC5 CCNG1 MBD3 PRDM1 MAP2K6 GATAD2B GATAD2A CDK5 MDM2 MDM4 TAF4B PRR5 DYRK2 CHD4 KMT5A ZNF385A TBP TAF9 TAF1L RNF34 AURKA MTA2 TAF15 TAF12 RBBP4 TAF13 MAPKAPK5 TAF11 DAXX RBBP7 TAF8 TAF7 RFFL TAF6 TAF5 PPP2R1B TAF4 PPP2R1A TAF3 TAF2 PML TAF1 PIP4K2A TAF10 TP53RK PIP4K2B EP300 PIP4K2C AKT2 CHEK2 SMYD2 PDPK1 NUAK1 TP53BP2 BANP MAPKAP1 TPX2 BRPF1 BRPF3 PRMT5 PLK3 PPP2R5C HDAC1 CDKN2A SGK1 PIN1 CDK2 PPP1R13B PPP1R13L PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 PPP2CA NOC2L STK11 PPP2CB MLST8 CHD3 TAF7L ING5 ING2 PRKAB2 PIP4P1 TP53INP1 HDAC2 PRKAB1 MTOR JMY BRD1 AKT1 MEAF6 BRD7 UBA52 CDK1 HIPK1 POU4F1 BLM POU4F2 MRE11 TP63 HIPK2 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 SUPT16H L3MBTL1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CSNK2A2 TAF9B RAD50 CSNK2B TP73 KAT6A RPA3 RAD17 TP53 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A AKT3 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation LTF REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity XIAP RNF146 TNKS PREX2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 STUB1 PSMA6 PSMA3 TRIM27 PSMA4 WWP2 PSMA1 NEDD4 MKRN1 PSMA2 FRK UBA52 PSMD12 USP13 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A AKT2 ADRM1 CSNK2A1 PSMC5 OTUD3 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 AKT3 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 CYP17A1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants FLT3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 GIT1 CALM1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMA1 KCNMB1 CHRNA9 CHRNA10 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MLH1 RPA3 EXO1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) STPG4 METTL23 YAP1 UHRF1 H2BC9 DPPA4 H2AZ2 DPPA3 H4C9 DPPA2 H2BC8 ZFP36L2 H2BC5 LEUTX H2BC3 PAIP1 NPM2 H2BC1 KDM4E TPRX1 AICDA SRPK1 H2AC20 H1-8 TPRX2 ZSCAN4 HIRA CNOT4 CNOT6 CNOT7 EIF4E DICER1 EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 CNOT11 KDM5B TEAD4 PABPN1 PABPC1 TET3 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 BTG4 CNOT6L EIF4A2 H2BC12 KDM5A H2BC13 EIF4A1 H2BC14 TUT7 KDM6A H2AJ TUT4 H2BC15 EIF4G1 DUX4 TP53 PABPN1L H2BC11 TPRXL EIF4A3 DUXA DUXB DIS3L2 KDM6B PRM2 PRM1 H3C15 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA1 GNG13 GNB2 GNB1 AP2A1 ADCY9 GNB4 GNAL GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 CHRNA9 RASGRF2 PRKAR1B PRKAR2B PRKCB PRKAR1A RAC1 HRAS PRKAR2A PRKX PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF9 NRAS GRIP1 MAPK1 GNAT3 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 CHRNA1 CHRNA3 PRKAA1 CHRNA2 PRKAA2 MAPK3 CHRNA5 CHRNA4 CHRNA7 PRKAG1 CHRNA6 PRKAG2 EPB41L1 PRKAG3 TSPAN7 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK4 GRIK1 PRKAB2 GRIA1 GRIK2 GABRR3 CAMK2B GRIA2 GABRR2 GABRR1 CAMK2D NPTN SRC ACTN2 PRKAB1 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B NRGN PICK1 GRIN2D GNAI3 AKAP5 GRIN1 DLG1 GNAI1 GRIN2A NCALD DLG2 GNAI2 DLG3 CHRND LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE PRKCA CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 GIT1 KCNJ16 GLRB CAMK4 CAMKK1 CAMKK2 KPNA2 PRKCG GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade RHO PDE6G CNGA1 GNB1 GNAT1 SLC24A1 SAG PDE6B CNGB1 GNGT1 PDE6A DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 EED H2BC3 H2BC1 H2AC20 GSDME RBBP4 EZH2 RBBP7 PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock FBXL3 CDK5 RORC RORA RORB SMARCD3 BTRC CARM1 PPP1CC NAMPT EP300 MED1 KMT2A RXRA SERPINE1 HDAC3 NR1D1 NRIP1 TBL1X BMAL1 NCOA1 ATF2 NCOR1 MEF2C TBL1XR1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PPARGC1A PSMA6 PSMA3 UBE2D1 NCOA2 PSMA4 PSMA1 NCOA6 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PPP1CA PSMD13 PSMA7 PSMB6 CRTC2 PSMB7 CRTC3 CRTC1 CSNK1D PSMB4 CPT1A PPP1CB SIK1 PSMB5 CSNK1E CLOCK NPAS2 UBB HELZ2 PSMB2 RAI1 PSMB3 CREBBP BHLHE40 UBC CHD9 BHLHE41 PSMB1 RBM4 DBP RPS27A TFEB KLF15 FBXW11 CRY2 CRY1 AVP CIPC ADRM1 CSNK2A1 FBXL21P NOCT TGS1 PSMC5 CSNK2A2 MEF2D PSMC6 SEM1 PER2 PSMC3 PER1 PSMC4 F7 PER3 PSMC1 CSNK2B PSMC2 BMAL2 SIRT1 SKP1 SREBF1 CUL1 PPARA REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity GJA1 TJP1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 PIK3R1 PIK3CA SRC IRS1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L KCNJ11 SLC5A1 ABCC8 SLC5A2 ABCC9 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 SLC67A1 RNF185 SLC26A3 APOA1 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 VCP SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC6A19 SLC27A4 SLC36A2 SLC6A14 SLC7A7 SLC7A9 GCKR GCK ABCA1 ABCG8 ABCG5 ABCA3 PSMD8 PSMD6 HK1 PSMD7 PSMD2 PSMD3 PSMD1 NUP214 SLC5A5 PSMA5 SLC35C1 PSMA6 CFTR PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 SLC24A1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SLC17A5 RPS27A SLC9A6 AVP ADRM1 SLC9A9 PSMC5 PSMC6 SEM1 SLC35A1 PSMC3 PSMC4 PSMC1 PSMC2 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes CREBBP ATF4 MAFK NFE2L2 EP300 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARL13B INPP5E PDE6D CCT2 CCT3 SMO TCP1 ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP HDAC6 BBIP1 RHO RAB11A ATAT1 TTC8 CNGB1 RAB8A SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CCND1 MAMLD1 RBPJ TNRC6C MOV10 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B ELANE E2F1 E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation BRD7 BRPF1 BRPF3 HDAC1 MTA2 PIN1 RBBP4 MBD3 MAP2K6 RBBP7 GATAD2B GATAD2A PML CHD3 ING5 PIP4K2A ING2 PIP4K2B PIP4P1 EP300 PIP4K2C AKT2 HDAC2 BRD1 KAT6A TP53 CHD4 MEAF6 AKT1 AKT3 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM NCBP1 NCBP2 FGF1 POLR2A FGF2 POLR2B FGFR2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB ZFP36 DCP1A EXOSC7 EXOSC6 EXOSC5 TNPO1 EXOSC4 DIS3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) PCNA YY1 RUVBL1 PARP1 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 RBX1 NFRKB CCNH ACTR5 RAD23A ACTR8 RAD23B CETN2 UBA52 INO80 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB UBB TFPT ACTL6A LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 DDB2 POLD1 RPS27A POLE POLD2 PIAS3 RFC2 RFC1 PARP2 USP45 LIG3 RPA1 RNF111 CHD1L DDB1 RPA2 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 COPS6 COPS5 MCRS1 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD NCAN CSPG4 CHST3 BGN DCN BCAN VCAN CSPG5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID BBC3 BCL2 BCL2L11 STAT3 PMAIP1 BCL2L1 BAD BMF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism ACSS3 BDH2 BDH1 HMGCL OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development YAP1 RBM14 HES1 BGLAP ABL1 RB1 MAF HDAC3 COL1A1 MAPK1 HDAC6 SP7 IHH UCMA MAPK3 GLI3 SMAD1 GLI2 SMAD4 HEY1 HEY2 SMAD6 HDAC4 SRC WWTR1 YES1 SATB2 CBFB ZNF521 AR OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency OTC HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs FKBP5 HSP90AA1 DYNLL1 DCTN6 DCTN5 ACTR1A HSP90AB1 DCTN1 DYNLL2 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 CAPZA3 DNAJA4 DNAJA2 CAPZA2 DYNC1I2 FKBP4 NR3C1 ACTR10 STIP1 HSPA1B CAPZB DYNC1LI1 DYNC1I1 DYNC1LI2 DCTN2 HSPA8 DYNC1H1 CAPZA1 DCTN3 HSPA1A PGR AR REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling IFNG JAK2 JAK1 SOCS3 PTPN6 PIAS1 PTPN1 SOCS1 SUMO1 IFNGR1 IFNGR2 PTPN11 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD CSPG4 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 B3GAT3 CSPG5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 YAP1 BGLAP ABL1 IHH NR3C1 ESRRA STAT1 MSX2 SMAD1 SMAD4 ESR1 BMP2 ZNF521 RBM14 RB1 MAF HDAC6 SKP2 CDK4 DLX5 DLX6 AKT2 SOX9 RUNX1 TWIST2 TWIST1 CBFB ITGA5 CDKN1A HDAC3 MAPK1 CCND1 SP7 MAPK3 NKX3-2 GLI3 GLI2 HAND2 PPM1D SMURF1 SMAD6 HDAC4 SRC SATB2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B AR PSMA5 STUB1 PPARGC1A PSMA6 PSMA3 PSMA4 PPARGC1B PSMA1 CCNB1 PSMA2 HES1 LGALS3 UBA52 PSMD12 PSMD11 CDK1 COL1A1 PSMD14 WWP1 BAX PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UCMA PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 HEY2 HIVEP3 ADRM1 WWTR1 YES1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 ITGBL1 PSMC2 SKP1 MMP13 CUL1 AKT3 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB IKBKB SQSTM1 UBC MYD88 RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR PRKCI UBB RIPK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 SKP2 CCNE2 KPNB1 PRIM2 CCNE1 PRIM1 POLA1 H2AX POLA2 LIG1 H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 KPNA6 POLRMT POLG2 RNASEH1 FEN1 MCM10 POLG TWNK DBF4 MGME1 EXOG RPA4 SSBP1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 TOP3A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation PCNA GINS1 GINS2 CDC45 GINS3 GINS4 PRIM2 PRIM1 POLA1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 MCM7 MCM8 RPA3 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RRAS FES PLXNA2 TLN1 PIP5K1C FARP2 PLXNA3 RAC1 FYN RND1 PLXNA4 NRP1 PLXNA1 SEMA3A ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization PERP PI3 CAPNS1 CAPN1 PKP1 DSP DSG1 DSG3 LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G DSG2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 FURIN PCSK6 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KRT12 KLK14 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 JUP KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PKP4 LELP1 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 CELA2A KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate DCXR AKR1A1 SORD CRYL1 XYLB IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AZ2 H4C9 PRMT6 PRMT5 SMARCB1 SMARCD1 PRMT1 SMARCD2 SMARCD3 H2AC20 H2AC1 H2AC25 H2AC21 CCND1 JAK2 SMARCC1 SMARCC2 PRMT7 PRMT3 CARM1 RBBP7 WDR77 COPRS CDK4 ARID2 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2AC14 RPS2 H3C8 H2AC8 H2AC6 H2AC7 SMARCA2 ACTL6B SMARCA4 H2AC17 H2AC12 H2AJ DNMT3A WDR5 ARID1A ARID1B H3C15 PBRM1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IPPK IPMK IP6K1 IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR10 MTMR2 MTMR12 PIK3C2A MTMR4 MTM1 PIK3R4 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3C3 VAC14 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation PTK6 PTPN1 SRMS EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis RASGRP2 RASGRP1 ITPR1 ITPR2 MGLL ITPR3 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 TRPC7 ABHD12 PRKCH TRPC6 DGKZ DGKQ PRKCQ TRPC3 PRKCE DAGLB DGKK DGKI DGKH PRKCD RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle RXRA MID1IP1 SLC22A5 SLC25A20 CPT1B PPARD PRKAB2 CPT1A PRKAA2 CPT2 PRKAG2 THRSP G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events TIAM1 GNG13 ARHGEF9 SOS1 OBSCN GNB2 ARHGEF3 ARHGEF4 GNB1 ARHGEF1 ARHGEF2 ARHGEF7 GNB4 SOS2 GNB3 RHOC ARHGEF5 NGEF GNB5 ARHGEF6 ARHGEF26 GNGT1 RHOA KALRN RHOB FGD1 FGD2 GNGT2 ROCK1 GNA13 ROCK2 FGD3 ABR FGD4 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 GNG3 GNG2 GNG5 GNG4 TBXA2R GNG7 GNG8 BTK GNA12 PLXNB1 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 GNG10 ADRA1D ARHGEF16 ARHGEF19 ADRA1B ARHGEF18 VAV1 ADRA1A VAV2 GNG12 TIAM2 GNG11 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID IKBKB NFKB2 RELA CHUK NFKB1 NFKBIA IKBKG SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 EHHADH ABCD1 DECR2 SLC27A2 ACOT4 ACAA1 ACOT8 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling DNMT1 SIN3A STAT3 PRDM1 EP300 CD274 HDAC1 IL2RG HIF1A HDAC2 HDAC3 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PIK3CB STRN SOS1 KDR FIP1L1 STAT3 PIK3R2 PIK3R1 NRAS PDGFRA HRAS WDR48 STAT1 PIK3CA KANK1 ETV6 GOLGA4 BIN2 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 MAP2K5 MAPK7 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid RXRA PPARD DHRS4 PDHB RXRG PDK3 DLAT RXRB PDK2 PDK1 PDHX PDHA2 PDHA1 RARG FABP5 CYP26A1 CYP26B1 CYP26C1 ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 PDK4 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 RARB ALDH8A1 RARA DLD ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) RXRA GGPS1 SCD CYP51A1 FASN LSS SREBF2 SQLE NCOA2 MTF1 DHCR7 NCOA6 SMARCD3 ACACB GPAM NFYA MVD NFYB NFYC TBL1X CARM1 NCOA1 HELZ2 CREBBP CHD9 SP1 TBL1XR1 ACACA MED1 TGS1 IDI1 MVK ELOVL6 TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling NEDD4L STUB1 PMEPA1 BAMBI STRAP UBA52 TGFB1 TGFBR1 TGFBR2 PPP1CA USP15 PPP1R15A PPP1CB PPP1CC UBB UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD3 SMURF2 SMAD7 SMURF1 XPO1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism ARSB GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 GBA1 NEU2 ENPP7 NEU3 ARSA SUMF2 SUMF1 NEU1 ASAH1 ASAH2 ARSL ARSJ ARSK PSAP ARSH ARSI CTSA ARSF HEXB ARSG HEXA ARSD GLB1L3 M6PR GLB1L2 GALC GLA GLB1L GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 EGF HES1 EGFR WWC1 NEURL1B UBA52 DLGAP5 HES5 PLXND1 APH1A PTCRA DLL4 MIB2 PSENEN PBX1 NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 TACC3 MAMLD1 PSEN1 STAT1 UBB RBPJ CREBBP UBC MAML2 FABP7 MAML1 RPS27A YBX1 HEY1 KAT2B KAT2A EP300 JAG2 SNW1 HEY2 JAG1 DLL1 MAML3 NOTCH3 NOTCH1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS AP2A1 AP2A2 FURIN SAP30L AP2M1 ATP1B3 ATP1B2 ROCK1 ATP1B1 ROCK2 CUL3 IGHV3-23 ARID4A IGLV MBD3 COMT IGLV2-8 NR3C1 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 GATAD2B IGHV3-30 RIPK1 GATAD2A IL1R1 SUDS3 IGHV3-33 AP2S1 IGKV1D-39 ZBP1 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 FXYD4 PHF21A FXYD3 CD79B IGLV2-11 FXYD2 CD79A IGLV1-40 FXYD1 IGLV1-47 IGLV6-57 FXYD7 IGLV2-14 FXYD6 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CHD4 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV SAP18 IGKV2-29 IGKV2-28 IGLC3 ATP1A4 BLNK ATP1A3 HMG20B MTA2 IGLC1 ATP1A2 FNTB IGLC2 S1PR1 JAK3 ATP1A1 SIGMAR1 RBBP4 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 REST IGLV3-19 MTA3 IGHV2-70 RBBP7 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FNTA BRD4 CRBN IGLC7 IGHV3-53 IGKV5-2 NCK1 STAT2 IGLC6 IL6R IGKV1-5 IMPDH1 IMPDH2 PDCD1 ITGB1 VAV1 TLR9 SOS1 HDAC1 HSP90AB1 KDM1A PTGES3 FKBP4 IFNGR1 IFNGR2 ITGA4 CHD3 HDAC2 FKBP1A KEAP1 RBX1 BTK JAK2 TUBB ARID4B JAK1 SAP30 TYK2 NFE2L2 SYK SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling RRAS PLXNB1 ERBB2 RHOC ARHGAP35 SEMA4D RHOA LIMK2 RHOB LIMK1 RAC1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MET MYH10 MYL9 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 FKBP5 HTT HDAC1 GAD1 SGK1 GAD2 HDAC3 GPS2 SIN3A PRKACA MET TBL1X DGCR8 PTPN1 AURKB NCOR2 TNRC6C GPRIN1 MOV10 NCOR1 MEF2C TBL1XR1 AGO3 IRAK1 AGO4 RBFOX1 CAMK2B GRIA2 AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A GRIN2B PTEN SLC2A3 GRIN2A TRPC3 OPRM1 SST CALM1 CAMK2G PTPN4 CRH OPRK1 LBR HIPK2 PVALB FOXG1 SOX2 MOBP GAMT DLL1 CAMK4 BDNF PPARG CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation MIB2 ITCH HSPA5 SAR1B TLR1 S100A9 S100A8 TLR2 STX4 UBE2L3 CD14 BTRC TLR4 LY96 RNF111 UBE2V2 LRR1 HMGB1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SEC31A SOCS1 HACE1 SIAH1 LNPEP MEX3C IKBKB UBAC1 FBXL8 MYD88 CD207 CALR CANX FBXL4 DZIP3 RNF220 DET1 LRSAM1 CTSS MRC2 TRIM9 MRC1 ARIH2 LRRC41 VAMP8 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 TLR6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 PSMB8 PSMB9 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 NCF1 KLHL5 PSMA5 RLIM NCF2 PSMA6 TRIP12 NCF4 PSMA3 KBTBD7 SNAP23 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 BTK RNF19B UBE3A PSMD12 SEC61G UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 SEC61B NPEPPS PSMD13 RNF19A PSMA7 PDIA3 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 S100A1 UBE2E3 CYBB TRIM4 PSMB4 FBXO17 TAP2 CYBA PSMB5 FBXO15 IKBKG UBE2E2 TAP1 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 VAMP3 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 PSME2 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 CUL3 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 RBBP6 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 SMURF2 ASB13 B2M ASB14 ASB11 RNF6 ASB12 HLA-A RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 SEC13 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 BECN1 SEC24D ASB2 ASB3 SEC24C SKP2 ASB1 CDC20 SOCS3 PIK3C3 ITGAV SH3RF1 ITGB5 PIK3R4 FBXO32 CHUK MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 CD36 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FGB FGA FGG FBXW11 FBXL21P SEM1 SKP1 CTSV CTSL CUL1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis ENO1 TRIM27 KPNA1 UBA52 ATP6V1H MAPK1 CTSG DUSP16 VPS33B CORO1A PGK1 HGS RNF213 RAB5A KPNB1 MAPK3 UBB UBC RPS27A RAB7A B2M SFPQ MRC1 NOS2 LTF TLR2 GSK3A INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA AREG EGF EGFR EREG BTC EPGN SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF23 FGF4 FGFR1 FGF6 FGF9 FGF20 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events FURIN RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX ACE2 MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 ANO8 CSNK1A1 PARP14 ANO9 PARP8 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 UBA52 ST6GALNAC3 ST6GALNAC4 TMPRSS2 SRPK2 ANO10 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors CALCRL ADM2 ADM IAPP RAMP1 RAMP2 CALCA RAMP3 CALCB CALCR DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC TCN2 CD320 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle FURIN CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TBP NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 RANGAP1 TAF7L ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A F9 F10 TPST2 TPST1 F8 F2 VWF NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COL4A2 COL4A1 FTH1 SCGB3A2 MASP1 CALR FTL COL1A1 APOA1 COL1A2 APOB APOE COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus BANF1 XRCC6 XRCC4 KPNA1 XRCC5 LIG4 PSIP1 PPIA HMGA1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MKRN1 CDKN1A AKT2 TSC2 MDM2 CDKN1B CHUK AKT1S1 GSK3A AKT1 CASP9 BAD GSK3B AKT3 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones H2BC9 H4C9 H2BC8 H2BC5 H2BC3 SAP30L H2BC1 HDAC1 H2AC20 H2AC1 HDAC3 KDM1A GPS2 ARID4A MBD3 TBL1X GATAD2B GATAD2A SUDS3 NCOR2 CHD3 BRMS1 NCOR1 TBL1XR1 HDAC2 PHF21A H2AC17 H2AC12 CHD4 RCOR1 H2BC18 SAP18 HMG20B HDAC8 MTA2 H2AC25 H2AC21 RBBP4 MTA1 REST ARID4B MTA3 RBBP7 SAP30 H2AC19 H2BC26 H2AC14 H2BC21 HDAC10 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 EGFR CDC37 NRAS PLCG1 NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification SEL1L RPN2 ERLIN1 TUSC3 PDCD1LG2 ERLIN2 B3GNT3 RPN1 SPOP MAGT1 MIB2 RNF185 CCND1 CUL3 VCP OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 DERL3 DERL1 OSTC DERL2 RNF5 ERLEC1 STT3A OS9 STT3B PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B YWHAG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PDCD1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 COPS5 CUL1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN CSPG4 BGN DCN BCAN VCAN CHST14 CSPG5 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function OPN1SW E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 H2BC3 PEX14 H2BC1 HLA-B RNF20 VCP UBE2J2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC UBA52 PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PEX2 UBB UBC RPS27A UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2B UBE2N PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 CRY2 CRY1 CSNK2A1 CSNK2A2 PER2 PPP1CA PER1 PER3 CSNK2B CSNK1D PPP1CB CSNK1E PPP1CC HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT SHH IHH DHH TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling CDC42 DCC NTN1 TRIO NCK1 SRC RAC1 ABLIM1 WASL ABLIM2 PTK2 ABLIM3 DOCK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 HSPG2 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L CD209 SDC4 SDC2 SDC3 CDK8 AGRN TLR3 IRF3 GPC1 IFNAR1 GPC3 MAVS GPC2 GPC5 GPC4 GPC6 RIGI TLR6 ELOB TLR2 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 CD14 BECN1 TLR7 IFIH1 JAK1 TLR4 UBB MED16 BCAP31 MED15 MED17 CREBBP UBC MED12 TYK2 MED14 MED13 RPS27A MED10 STAT2 EP300 CUL5 LY96 MED1 MED30 MED31 MED8 MED4 MED27 MED6 MED26 MED7 H2BC15 MED23 UBE2L6 MED25 IFNA5 HERC5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 HSPD1 TFAP2A NPM1 MYBL2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 APEH RPL7A RPL18A HEMK2 RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 TRMT112 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 CHAC1 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux RXRA CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB APOD APOE TBL1X NCOA1 ABCA1 ABCG8 KDM4A ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 EP300 APOC2 APOC1 AGO1 AGO2 TNRC6A ABCG1 TNRC6B NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors NKX2-5 KAT2B WWTR1 HIPK1 HIPK2 MME NPR1 NPR2 TBX5 NPPC CORIN CES1 GATA4 NPPA CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic PCNA YWHAE EML4 CDCA5 MYBL2 NCAPG YWHAG ARPP19 NCAPH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 CHMP3 CHMP6 CHMP7 CDC7 FBXL18 FBXL7 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH LYN CDKN2B CDK7 MNAT1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 ABL1 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 JAK2 PPP1CB HJURP RFC5 PPP2R2A RFC3 PPME1 GTSE1 RFC4 BORA FKBPL RFC2 FBXW11 OPTN OBI1 HMMR RPA1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B TICRR MCM7 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MYC PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 HAUS8 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 KMT5A HSP90AA1 CDC25C CDKN1C RB1 CDKN1B CCND3 FZR1 CCND2 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX CPAP LIG1 MAX H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 RCC1 H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 GSK3B PHLDA1 AKT3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation UPK1A EPCAM METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids ACSS3 MED19 SLC22A5 ABCB4 MED18 MED11 AGPAT2 SLCO1B1 SLCO1B3 MED9 MED29 MED28 MED22 MED21 THRSP GPAM GAL3ST1 CERK GBA3 CDK19 GBA2 SMPD3 SMPD2 STS SMPD4 MED13L GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLA2G4A SUMF1 B3GNT5 GGT5 B4GALT6 B4GALT5 ASAH1 ASAH2 ABCB11 FUT2 FUT1 UGCG UGT8 ARSL ARSJ GGT1 ARSK VDR PSAP ARSH ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC CYP2C9 NDUFAB1 CYP2C8 CYP2U1 CYP4F2 CARM1 CYP1A2 RAB5A KPNB1 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PIP4K2A NSDHL PIP4K2B LIPI PIP4K2C CYP2D6 LIPH FDXR SULT2A1 MED1 STARD3 BMX ACOT9 STARD4 STARD5 ACOT7 MED8 MECR STARD6 MED4 STARD7 MED6 MED7 RUFY1 CH25H PRKD3 FDX1 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 TIAM2 CYP2E1 FAR2 MTMR3 MTMR8 CGA BDH2 PLA2G3 BDH1 MTMR9 OXCT1 PLA2G5 OXCT2 PLA2G6 HMGCS2 MTMR6 HMGCLL1 MTMR7 AACS HSD11B1 ACAT1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA PTGES3 CYP4F3 NR1D1 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE CYP27B1 TSPO SPHK2 PTGR1 CYP24A1 PTGR2 CYP21A2 CYP2R1 AHRR SAMD8 PIP4P1 ECHS1 SGMS1 SGMS2 UBE2I PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIP5K1C PIAS4 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 INPP5D ABHD4 PIK3CG ABHD3 PIK3R6 INSIG2 PIK3R5 INSIG1 ARF1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 GBA1 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 CSNK2A1 PLA2G12A CERS5 GPX1 CSNK2A2 CERS6 GPX4 FAAH2 TNFRSF21 CERS1 CSNK2B CERS2 PPM1L HSD17B14 TPTE LRP2 CYP3A4 HSD17B11 MMAA MMUT AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 MBOAT1 DDHD2 MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PCCA PITPNB CPNE7 ECI1 PCCB CPNE6 GDE1 ACACB ACSM6 CPNE1 CPNE3 PTGDS MFSD2B ACAD11 SPHK1 ACAD10 MFSD2A SACM1L SLC51A ESRRA SLC51B PISD CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 CDK8 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 MTMR1 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPX2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS CBR1 SMARCD3 PCYT1B PCYT1A STARD3NL PLAAT1 PLAAT3 PLAAT2 CYP7B1 PLAAT5 PLAAT4 AKR1D1 GDPD1 ALOX12B GDPD3 GDPD5 HSD17B7 CYP7A1 ORMDL2 PPP1CC HSD17B1 TXNRD1 ORMDL3 HSD17B2 PIK3CB SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CYP8B1 ETNPPL PLEKHA8 PNPLA3 PTPN13 PNPLA6 VAPB ACAA2 INPPL1 MSMO1 CYP46A1 PLB1 ENPP6 PIK3CA PIK3R3 SBF1 HADH SBF2 PIK3C3 TPTE2 TRIB3 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 THEM4 CHAT PLD4 PLD6 ARNT2 PLD3 NFYA ALDH3B2 NFYB EBP NFYC CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 BMAL1 ACBD6 ACBD4 DGAT2L6 CRLS1 ACSF2 CYP11B2 PI4KA VAC14 PI4K2B PLD2 DEGS1 MTMR10 ALPI MTMR2 DEGS2 MTMR12 PI4KB PIK3C2A ACBD5 TNFAIP8 MTMR4 CYP4A22 MTM1 DBI INPP4A PCTP FIG4 ACOXL INPP4B ABCC3 PLA2G4F PIKFYVE INPP5F ABCC1 PI4K2A PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L ME1 CPT2 POMC MID1IP1 SLC25A20 PPP1CA CPT1B CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT PPP1CB CYP11B1 AKR1C3 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 LDLRAP1 CUBN APOA2 APOA1 PRKACG APOA5 PRKACA PRKACB ANGPTL4 SAR1B MBTPS1 ALB MBTPS2 PLA2G2A SLC27A1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 PRKAA2 PHYH ACOT8 PRKAG2 GNPAT ACOT2 ACOT4 PRKAB2 HACL1 DECR2 HAO2 EPHX2 PPARGC1A AMACR PPARGC1B RAN MAPKAPK2 CROT LBR ABCD1 OCRL BAAT MED16 SLC25A17 MED15 ACOX2 MED17 MED12 EHHADH MED14 MED13 AGPS ACOX3 MED10 TAFAZZIN HSD17B4 MED27 HMGCL MED26 MED23 MED25 MED24 MED20 PPARG CAV1 PPARA SRD5A3 PPARD NUDT7 VAPA CRAT SEC23A HEXB HEXA LTC4S RORA GLB1L3 GLB1L2 GLB1L SEC24B GLB1 SEC24A PLD1 ARSB HADHB HADHA ACADVL CYP17A1 SEC24D SEC24C EP300 MED30 MED31 RXRA INPP5E HDAC3 MOGAT3 MOGAT2 MOGAT1 GPS2 ABHD5 FABP12 RXRB GK3 GK2 LIPE AGMO GPAT2 TBL1X DGAT2 GK NCOA1 ABCA1 DGAT1 FABP9 FABP1 FABP2 FABP3 NR1H2 FABP4 FABP5 NR1H3 GPD2 NCOR2 FABP7 ARNT PNPLA4 PLIN3 NCOR1 PNPLA5 TBL1XR1 LPIN1 FABP6 LPIN2 MGLL SUMO2 LPIN3 PLIN1 PEX11A CD36 NCOA2 NCOA6 NCOA3 CCNC MVD PLIN2 ST6GALNAC5 ST6GALNAC6 PNPLA2 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 CREBBP SP1 NEU1 CHD9 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA TGS1 SREBF1 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGF ERBB2 MEMO1 EGFR RHOA NRG1 DIAPH1 EREG NRG3 NRG4 NRG2 BTC REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins JUP PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 SOX10 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 CDH19 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 SV2C SV2B SV2A VAMP1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 PRKAB2 PRKAA2 ADIPOQ MLXIPL PRKAG2 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression ASAH1 DICER1 TRPM1 PXN SMARCD1 SMARCD2 SMARCD3 SMARCE1 LIG1 GMPR SOX2 AKT2 ATP6V1E1 ATP6V1G1 ATP6V0B ATP6V0E1 DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H TBX2 HINT1 CCND1 ITGA2 SIN3A CDK2 CTNNB1 MET ATP6V1C1 GPR143 TNRC6C MOV10 TFAP2A AGO3 STT3B AGO4 CDH1 AGO1 AGO2 DPF1 TNRC6A TNRC6B DPF2 DPF3 SS18L1 ARID1A ARID1B PPARGC1A PLK1 SS18 SMARCB1 CCNB1 SOX10 SMARCC1 BRCA1 SMARCC2 ACTB ACTL6A GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CCND1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 GSK3B RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 TRMT10C FASTKD2 PRORP MTERF4 ELAC2 TFB1M MRM1 HSD17B10 MRM2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing NFKB2 CTSG RELA IL18 IL1A CASP1 NFKB1 IL1B GSDMD PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B PIWIL2 POLR2C TDRKH POLR2D HSP90AA1 PIWIL1 POLR2E HENMT1 POLR2F ASZ1 POLR2G MAEL POLR2H MOV10L1 POLR2I POLR2J MYBL1 POLR2K TDRD9 POLR2L TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 PIWIL4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation HDAC6 HSBP1 PTGES3 EEF1A1 HSF1 YWHAE RPA3 HSP90AA1 VCP RPA1 HSP90AB1 RPA2 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 OGG1 NEIL1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 CTNNB1 AXIN2 TCF7L2 TCF7L1 MYC LEF1 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle FURIN CCR5 CXCR4 CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 TBP NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 HMGA1 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 LIG1 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 XRCC6 CHMP7 XRCC4 XRCC5 LIG4 RANGAP1 TAF7L FEN1 ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events KNG1 RASGRP2 RASGRP1 NPFFR2 OXTR NPFFR1 RGSL1 GRPR AVPR1B CYSLTR1 EDNRA EDNRB PROK2 PROK1 AVPR1A UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT NTSR1 NTSR2 ITPR1 GPR17 ITPR2 NMB ITPR3 XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN TRPC7 BRS3 GPRC6A GPR132 TRPC6 CCKAR GNRHR TRPC3 FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R MCHR1 P2RY10 P2RY11 LPAR1 GCGR LPAR2 GPR4 LPAR3 GCG LPAR5 MT-RNR2 F2RL1 F2RL2 CHRM3 F2RL3 CHRM1 GPR68 GPR65 CHRM5 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 TRIO MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 PRKCQ PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 RGS16 ADRA1D P2RY6 HTR2A P2RY2 ADRA1B P2RY1 RGS21 ADRA1A CCK HRH1 HCRTR2 HCRTR1 KISS1 HBEGF MAPK7 KALRN GPR143 PTGFR PTGER1 TBXA2R AGT PRKCD PRKCA BTK GRK2 PRKCE GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 FFAR1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARHGEF25 EGFR HRAS PIK3R3 PIK3CA SOS1 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 MGLL DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ DAGLB DGKK DGKI DGKH AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL1A1 COL25A1 COL1A2 COL22A1 COL23A1 COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL20A1 COL4A6 COL6A3 COL21A1 COL9A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COL3A1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 DCP2 MAPK11 PARN EXOSC7 KHSRP EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 FGF20 FGF16 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions OCLN RUNX1 TJP1 CBFB CLDN5 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex PCNA UBA52 WDR48 RAD18 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2B POLE2 POLE3 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACSM6 ECHS1 ACSM3 ACADS HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) STPG4 UHRF1 H2BC9 METTL23 H2AZ2 H4C9 DPPA3 H2BC8 H2BC5 H2BC3 H2BC1 AICDA H2AC20 TET3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KDM5B H2BC12 KDM5A H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 KDM6B H3C15 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6C MOV10 AGO3 AGO4 CD274 AGO1 AGO2 TNRC6A TNRC6B RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G POLR3H POLR2K POLR3K POLR2L POLR1C POLR1D MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation MET HGF SPINT1 HPN SPINT2 HGFAC PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade PIK3R4 PIK3R2 PIK3R1 FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis PARP1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum POFUT1 NOTCH2 NOTCH3 NOTCH1 POGLUT1 NOTCH4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events AKT2 PDE3B POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels GNG13 GNB2 KCNJ8 GNB1 KCNJ11 ABCC8 ABCC9 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNMA1 GNG3 GNG2 GNG5 GNG4 GNG7 KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK1 KCNN2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ2 KCNJ2 KCNQ3 KCNJ3 KCNQ4 KCNJ4 KCNQ5 KCNV1 KCNV2 GABBR2 KCNN1 KCNJ5 KCNN3 KCNN4 KCNJ6 KCNF1 GABBR1 KCNC1 KCNJ10 KCNK9 KCNC2 KCNJ12 KCNC3 KCNJ9 KCNC4 KCND1 KCND2 KCND3 KCNJ15 KCNAB1 KCNJ16 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 KCNK4 HCN1 GNG10 GNG12 GNG11 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction SORBS3 MYL5 MYL7 ITGA1 PXN ITGB5 GUCY1B2 GUCY1B1 TPM4 TPM3 GUCY1A2 GUCY1A1 PDE5A ANXA2 TLN1 VCL TRIM72 DYSF PAK1 LMOD1 MYL6B MYL12B CACNA1H MYL6 MYL12A MYLK CACNA1G MYH11 CACNA1I MYL9 ALDH2 CALD1 PAK2 ANXA6 MYL10 CAV3 TPM2 MYL11 CALM1 TPM1 ANXA1 SORBS1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C OXA1L KGD4 UCP1 NDUFAB1 ACAT1 MT-CO1 BCS1L COX19 COX17 ATP5MC1 SCO2 MT-CO2 MT-CO3 CYC1 CS VDAC1 ACO2 UBA52 HSCB HSPA9 TIMM21 UBB UBC RPS27A SLC25A12 FXN SLC25A13 NDUFB8 ATP5F1A SIRT3 ATP5F1B IDH3G CYCS MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 PC CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D LETM1 MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SLC25A4 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ATP5MK COX11 ATP5MJ COX14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5MF ATP5ME COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 COXFA4 NDUFA6 FAHD1 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 PDK4 NDUFS3 WDR26 PDHB GOT2 RMND5B LDHA MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 ECSIT PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 COX7B GPT COX7C COX8A COX8C DLD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A IK SNRPN PRP4K WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response XIAP CARD8 CYCS UACA MAPK1 AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells FGF10 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K4 IKBKB UBC RPS27A FBXW11 NFKB1 TNIP2 UBA52 BTRC CHUK SKP1 MAP2K1 MAP3K8 IKBKG CUL1 UBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins MUC13 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 MUC1 POMT2 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 POMT1 MUC4 MUC6 POMGNT1 MUC16 GALNT3 B4GAT1 MUC17 C1GALT1 MUC19 DAG1 SSPOP MUC5B LARGE1 MUC20 MUC21 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 SH3GL1 UBA52 STAM STAM2 MET HGS UBB SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 DPH7 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEL1L RAD23B PRKCSH UBA52 RNF185 GANAB PDIA3 VCP EDEM2 MOGS UBB DERL1 UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 UBXN1 PSMC1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects PNP PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway CLTC CLTB FZD2 WNT5B FZD5 FZD7 WNT5A ROR1 FZD4 CLTA ROR2 AP2A1 PRICKLE1 FZD6 RAC2 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 RHOA AP2S1 SMURF2 SMURF1 AP2B1 PSMD8 PSMD6 PSMD7 PSMD2 ARRB2 PSMD3 SCRIB VANGL2 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DAAM1 PFN1 PARD6A ADRM1 PSMC5 PSMC6 RAC1 PRKCB SEM1 PSMC3 DVL1 PSMC4 DVL2 WNT4 PSMC1 DVL3 PSMC2 PRKCG WNT11 FZD3 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOT2 ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B KIF5A NCKIPSD RAP1GDS1 KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 VHL AR CFTR RHOT1 BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 LRRC41 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 CCNE1 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 PLIN3 NCOA2 PTK2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT5 GGT7 GGT6 DPEP2 GGT3P DPEP1 GGT1 ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CYP3A4 CYP1A2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R3B E2F1 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B POLA2 PPP2R1A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin F8 F2 VWF INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 ISL1 GIP DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C GATA4 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO SAE1 SENP5 SUMO3 SENP1 SUMO2 SENP2 UBE2I SUMO1 RWDD3 UBA2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HNRNPC BMI1 SUMO2 RING1 HNRNPK UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 NOP58 CBX2 PHC3 AAAS NUP160 NUP214 POM121C NUP42 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 KLB FGF16 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 ECHS1 ACAT1 MCCC1 PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A CSK RAF1 JAK2 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 IGF2 CTSG IGF1 TF CALU KLK3 KLK2 SERPINA1 MBTPS1 KLK13 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN PLG ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 LAMB2 PDIA6 PAPPA MXRA8 SPARCL1 FN1 IGFALS LAMB1 SCG2 KLK1 LAMC1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 GZMH NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC F2 GAS6 APLP2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling IFNA2 IFNA8 TYK2 IFNA13 IFNA14 IFNA16 STAT2 IFNA17 SOCS3 PTPN6 IFNAR1 IFNA10 IFNA21 IFNB1 JAK1 IFNA5 IFNA4 PTPN1 SOCS1 IFNA7 USP18 IFNA6 PTPN11 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CB RAPGEF1 CRK PIK3CD LYN PIK3R2 CBL PIK3R1 YES1 HCK BLNK SYK FYN PIK3R3 CRKL PIK3CA VAV1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling DPYSL3 FES PLXNA2 PLXNA3 CDK5 FYN PLXNA4 NRP1 CDK5R1 CRMP1 GSK3B DPYSL4 PLXNA1 DPYSL5 SEMA3A DPYSL2 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade SOS1 SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS FGF20 THEM4 MAPK1 FGF23 FGF22 KLB MAPK3 FLT3 IRS1 INSR PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade SERPING1 C3 CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PROS1 F2 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PFKFB1 PRKACA PRKACB MLXIPL ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells UPK1A EPCAM FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation FGF23 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism PNPLA7 PNPLA6 GDPD1 GDPD3 GDPD5 ENPP6 GDE1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3CA PIK3R3 PIK3R5 ICOSLG FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription CITED2 GCK FBXO32 G6PC1 CDKN1A INS HDAC1 NPY NFYA CCNG2 SIN3A NFYB NFYC BCL2L11 PLXNA4 FASLG PCK1 NR3C1 FOXO4 ATXN3 BTG1 DDIT3 TRIM63 STK11 SMAD2 SMAD4 AGRP SMAD3 BCL6 HDAC2 YWHAB TXNIP PINK1 AKT1 YWHAQ YWHAG RBL2 YWHAZ SFN PPARGC1A CAT ABCA6 RETN CDKN1B POMC SOD2 KLF4 CREBBP BBC3 FOXG1 KAT2B FOXO6 PCBP4 FOXO1 EP300 AKT2 IGFBP1 SIRT1 MSTN SIRT3 FOXO3 TXN SREBF1 GADD45A CAV1 AKT3 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex BICRAL ACTL6A BICRA BRD9 SS18 SMARCD1 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SS18L1 ACTB TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation SNAP25 RAB3A SLC32A1 STX1A SYT1 SLC6A13 HSPA8 ABAT SLC6A1 VAMP2 CPLX1 GAD1 RIMS1 GAD2 ALDH5A1 DNAJC5 SLC6A11 SLC6A12 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase OCLN DSG1 DSG3 PLEC ADD1 ROCK1 H1-1 H1-0 H1-3 LMNB1 CTNNB1 TJP1 H1-2 H1-5 H1-4 VIM CLSPN CDH1 SATB1 CASP6 PRKCD APC KPNA1 BIRC2 SPTAN1 DFFB DFFA DBNL ACIN1 KPNB1 GAS2 MAPT BCAP31 GSN TJP2 FNTA DSG2 PKP1 BMX STK24 STK26 HMGB2 HMGB1 PRKCQ CASP8 PAK2 PTK2 CASP7 DNM1L DSP CASP3 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants ALK DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair NEIL3 NEIL1 PMS2 MLH1 MSH2 MSH3 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 MSH6 RMI2 RFC3 RFC4 RMI1 OGG1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A NTHL1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling RELA MAP3K7 IL1RL1 IL33 CTSG MAP2K6 IL1RL2 IL36A IL36B IL1R1 IL36G IL36RN IL1F10 SMAD3 TBK1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 GSDMD USP14 BTRC IL18 NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 PTPN13 HMGB1 CASP8 MAP2K1 UBE2N STAT3 NFKB1 MAPK8 CHUK PTPN11 IKBKB SQSTM1 MYD88 SIGIRR IRAK3 ALOX5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 CASP1 PSMD1 PSMA5 PSMA6 PSMA3 PTPN4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL18RAP IL1R2 PSMD13 IL4 NFKB2 TOLLIP PSMA7 PTPN20 PTPN23 PSMB6 IL18BP IL13 PSMB7 IL1RAPL1 PSMB4 MAP3K3 NKIRAS1 PTPN18 NKIRAS2 PSMB5 IL37 MAP3K8 IKBKG PTPN12 UBB PTPN14 IKBIP RIPK2 PSMB2 PTPN9 MAP2K4 PSMB3 PTPN7 IRAK4 PTPN5 UBC IL18R1 PSMB1 PTPN2 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 PTPN6 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 ELAC2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG ABHD6 ABHD12 DAGLB MGLL DAGLA MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR3 CTSS CNPY3 TLR8 TLR7 CTSB CTSV CTSL LGMN CTSK HSP90B1 TLR9 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 HBS1L EXOSC7 NT5C3B EXOSC6 SKIC2 SKIC3 DCPS EXOSC5 EXOSC4 DIS3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 VCP SHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA PARP1 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 RFC2 RFC1 PARP2 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 PARG APEX1 ADPRS PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria PAH NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways NUP85 TPR KPNA7 NUP62 KPNA4 KPNA5 NUP88 GBP1 NUP43 KPNA3 RAE1 PABPN1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 EIF2AK2 ISG15 NUP37 KPNB1 MLKL KPNA2 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 GP1BA H2AC20 SETD1B SETD1A SIN3A ASH2L TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B NR4A3 MYL9 SIN3B DPY30 WDR5 GATA1 THBS1 RBBP5 PF4 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KAT2B KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 ZFPM1 PRKCQ H2BC11 KMT2A CBFB ITGA2B H3C15 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA CYP26B1 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation AGPAT2 ARPC5 GM2A ACTR2 APEH ARSA FGR ASAH1 PECAM1 RAB9B PSAP MGST1 MME GLA P2RX1 CAT IST1 CD14 GSDMD RETN SPTAN1 DBNL FUCA2 KPNB1 GSN TICAM2 DNAJC3 PKP1 SDCBP RAC1 CST3 HMGB1 DSP DSG1 C3AR1 MAGT1 LTA4H NCSTN ADAM10 PSEN1 CDK13 GOLGA7 C5AR1 ACTR10 HSPA1B DDOST LPCAT1 ALOX5 CD59 CD55 HPSE SNAP25 RAB3A DNAJC5 KRT1 CNN2 TOLLIP ANXA2 MIF PPIA CSNK2B CTSB CDA FRMPD3 RAB14 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 RNASE2 UNC13D FLG2 PADI2 FPR1 CPNE1 GNS CPNE3 PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 VCP FUCA1 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 HMOX2 SIGLEC5 GHDC TMEM179B RAB3D HP EPX SLC44A2 PYCARD RAB44 CR1 GLIPR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B RAB5C STK10 BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 FCAR ALAD FCGR3B ORMDL3 PGM2 ACP3 TCIRG1 SNAP29 PGM1 RNASET2 DYNC1LI1 TNFRSF1B PKM PTGES2 TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC CTSD TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 FAF2 PTPRN2 SIGLEC14 ATP6V0C STK11IP SURF4 PRG2 NBEAL2 PRG3 RHOG DYNLL1 DERA BST2 RHOF BST1 NRAS VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ MAPK1 ACTR1B CTSH CD33 CTSC CD53 ATP6V1D MANBA ALDH3B1 FCER1G GAA NME2 ATP6V0A1 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CD47 DEGS1 CD44 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 CKAP4 OSTF1 CD93 LRRC7 CD300A IRAG2 ATAD3B OSCAR TYROBP DOCK2 DOK3 COPB1 ADGRG3 MOSPD2 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 NAPRT ADGRE3 HGSNAT DYNLT1 ATP6AP2 ARMC8 PLAUR MMP8 MMP9 CHI3L1 PDXK BIN2 CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 RAB27A CEACAM1 LAMP2 PPIE ARG1 AP2A2 A1BG SLC15A4 RAP1B RAP1A CTSG NPC2 PPBP PRSS3 PGLYRP1 PRSS2 CAMP SERPINA3 ORM1 FPR2 SLC11A1 SERPINA1 RNASE3 ORM2 TRPM2 BPI QSOX1 PRTN3 S100A9 CAP1 S100A8 AHSG LTF TLR2 S100A7 CD63 PTAFR DEFA1B ELANE DEFA4 LYZ CAPN1 LCN2 AMPD3 APRT PNP IMPDH1 IMPDH2 EEF1A1 ACLY HLA-H SLC27A2 HLA-B HLA-C HSP90AB1 ACAA1 ATG7 CAB39 B4GALT1 CTSS VAMP8 PSMD6 PSMD7 HUWE1 PSMD2 PSMD3 LAMTOR2 LAMTOR1 PSMD1 LAMTOR3 CYFIP1 IDH1 PRKCD PSMA5 SNAP23 PSMA2 PSMD12 PSMD11 STBD1 PSMD14 CEP290 PSMD13 KCNAB2 TUBB PSMB7 CYBB CYBA PSMB1 RAB7A HSPA8 MAPK14 UBR4 PSMC3 PSMC2 HSPA1A NCKAP1L APAF1 CFD C3 ATP8A1 VAPA ATP11B CCT2 ATP11A ROCK1 ATP8B4 B2M STING1 AP1M1 HEXB GLB1 ARHGAP45 IQGAP1 ANO6 PLD1 GUSB IQGAP2 ARSB HSP90AA1 FRK JUP ARHGAP9 STOM ITGAV FTH1 FTL NDUFC2 XRCC6 XRCC5 NFKB1 ITGAX CHRNB4 ITGAL DGAT1 FABP5 GPI CD36 HK3 PGAM1 LGALS3 CFP ALDOC ALDOA PFKL NEU1 PTPN6 CTSA S100A12 EEF2 MLEC TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP PML UBC PTEN RPS27A NEDD4 USP7 UBA52 UBB MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins MET TNS4 TNS3 HGF ITGB1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling HBEGF EGF ERBB2 PIK3R1 EGFR NRG1 GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion PDS5B SMC1A SMC3 PDS5A WAPL STAG1 STAG2 ESCO1 RAD21 ESCO2 CDCA5 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation UGT2B7 UGT1A3 SLC35D1 SLC35D2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT1A9 UGT2B17 UGDH UGT2B4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CX3CR1 CCL3L3 CXCR5 CCR5 CXCR6 CXCR4 CCL7 CCR6 CCL5 CXCR3 PPBP CCL4 CCL3 CCL2 CCL1 CCL19 CCR2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 CXCL10 CXCR1 CXCL11 CXCL12 CXCR2 ACKR4 ACKR3 ACKR2 XCR1 CCL28 CCL27 CXCL1 PF4 XCL2 XCL1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism SERINC4 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 LBP CD14 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse LYN NGEF YES1 RHOA ROCK1 MYL12B FYN ROCK2 MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2S1 AP2A1 AP1G1 AP1S2 AP1S1 AP2A2 AP1S3 B2M AP1M2 AP2B1 AP1M1 AP1B1 HLA-A AP2M1 ARF1 CD8B PACS1 ATP6V1H LCK CD28 CD4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events NTRK1 KIDINS220 RAPGEF1 CRK NGF YWHAB MAPK1 RAP1A FRS2 MAP2K1 MAP2K2 CRKL MAPK3 BRAF NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR FLT1 NRP2 KDR NRP1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer PRF1 ICOS STAT5A IL10RA ZC3HC1 STAT3 CCNB1 HDAC1 NPM1 GZMB RB1 MAPK1 CEBPB MAPK3 DNMT1 FOXM1 TNRC6C MOV10 AGO3 AGO4 JUNB PTPN6 AGO1 AGO2 RPS6 IRF4 BCL2A1 SKP1 RBX1 TWIST1 ZAP70 CUL1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX4 ALOX12B ALOX15 ALOX12 GPX2 GPX1 ALOXE3 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) CYP51A1 EBP LBR DHCR7 MSMO1 NSDHL HSD17B7 TM7SF2 SC5D DHCR24 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules VASP ITK TRAC CD3G CD3E CD3D PLCG1 TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 EVL HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 NCK1 WAS PAK1 PAK3 LCK PLCG2 PAK2 ZAP70 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CACNA1D CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) RPS6KA1 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 SGK1 MAPK1 NAB1 NAB2 LYL1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 PPP2CA EGR3 PPP2CB JUND EGR4 FOSL1 ID2 ID1 MEF2C CDK5 ID4 FOSB ID3 CDK5R2 TCF12 CHD4 MAPKAPK2 REST ATF1 PPP2R1B PPP2R1A SH3GL3 VGF EP300 JUNB MAPK14 MAPK11 MEF2D FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs NEDD4L STUB1 ITGB8 ITGB5 FURIN PMEPA1 CBL BAMBI STRAP UBA52 TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 PPP1CA USP15 ITGA8 PPP1R15A PPP1CB PPP1CC TGFB2 UBB TGFB3 UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD4 SMAD3 SMURF2 SMAD7 SMURF1 NEDD8 TGFBR3 FKBP1A XPO1 LTBP4 ITGB3 ITGB1 LTBP3 LTBP1 ITGAV DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG1 UBC RPS27A RNF41 ERBB2 USP8 AKT1 AKT2 UBA52 NRG2 UBB AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors OXTR OXT AVPR1B AVP AVPR2 AVPR1A EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP8B1 TBXAS1 CYP4F3 CYP4A22 CYP4B1 CYP4F8 CYP4F2 CYP4A11 PTGIS CYP4F12 CYP4F22 CYP4F11 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment IKBKB RIPK1 UBC UBE2D1 TICAM1 RPS27A TLR3 UBE2V1 TRAF6 UBA52 BIRC2 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense SFN FNTA GBP1 FURIN GBP5 PIM1 PGGT1B GBP2 FNTB GBP4 GBP3 CASP1 ACTG1 ACTB PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 HEXB NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 RRP8 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 SUV39H1 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 SIRT1 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes PCBP4 TP53 CDKN1A ZNF385A RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 TEAD3 TEAD4 CCN2 RUNX3 WWTR1 TEAD1 TEAD2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity UBC PTPN2 SH3KBP1 RPS27A SH3GL3 EPS15 USP8 CBL SH3GL2 SH3GL1 UBA52 STAM PTPRJ LRIG1 STAM2 MET HGS HGF PTPN1 UBB NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 UBC RPS27A CBL UBA52 PTPRJ SLA ABL2 CSK SLA2 SOCS2 SOCS6 FLT3LG SH2B3 FLT3 UBB FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER CCNH RAD23A RAD23B PARP1 CETN2 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A DDB2 PIAS3 SUMO3 SUMO2 PARP2 USP45 UBE2I RPA1 PIAS1 RNF111 CHD1L SUMO1 RPA2 DDB1 UBE2V2 XPA XPC CUL4A RPA3 RBX1 ERCC4 ERCC1 UBE2N ERCC5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TICAM2 TICAM1 RIPK3 CASP8 LY96 FADD CD14 TLR4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 SLBP CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 PTPN12 NRG2 BTC TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation GP5 SERPINA5 GP9 SERPING1 A2M KLKB1 PRCP GP1BA KNG1 SERPINC1 C1QBP F9 PROC F10 SERPIND1 PROS1 F8 F2 VWF SERPINE2 GP1BB F12 F11 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions BAG4 FGFR1 ERLIN2 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling EPHB6 EFNB2 NCK2 EFNB1 ARHGEF7 EFNB3 EPHB2 EPHB1 SDCBP EPHB4 EPHB3 PAK1 PAK3 RAC1 FYN MYL12A GIT1 PAK2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation RIPK1 TICAM2 TRAF2 TNFRSF10B TICAM1 TNFSF10 TNFRSF10A LY96 FADD CD14 TRADD FAS FASLG CASP8 TLR4 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 ERBIN PRKCA SOS1 PTK6 STUB1 HBEGF SHC1 HSP90AA1 ERBB2 EGF USP8 PIK3R1 EGFR MEMO1 CDC37 NRAS PLCG1 UBA52 MATK RHOA PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 SRC YES1 HRAS NRG1 FYN GAB1 PRKCE DIAPH1 GRB7 AKT1 EREG NRG3 PIK3CA NRG4 NRG2 BTC AKT3 PRKCD DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN IL10 YES1 HCK SYK AHCYL1 FYN FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen GP5 GP9 ITGA1 LYN GP1BA GP6 ITGA10 FYN ITGA2 ADAMTS13 FCER1G VWF ITGB1 GP1BB PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs PAPOLA SYMPK NCBP1 CSTF2T NCBP2 CLP1 FIP1L1 PABPN1 CPSF4 CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 PCF11 CPSF2 CSTF2 WDR33 CSTF1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors NR1H2 NR5A1 RXRA PIAS4 NR2C1 PIAS3 ESR1 SUMO3 SUMO2 UBE2I VDR PIAS1 HDAC4 NR4A2 SUMO1 NR3C2 THRB RORA RARA NR3C1 PGR PPARG AR PPARA DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K POLR2L GTF2H1 CAVIN1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 TTF1 ERCC3 ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations DAG1 POMT2 POMT1 POMGNT1 MGAT5B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation NFATC2 AHCYL1 NFATC3 PPP3CA PPP3CB NFATC1 ITPR1 ITPR2 ITPR3 PPP3R1 CALM1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 CYSLTR1 CYSLTR2 DPEP1 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PTK6 CDKN1A CDC25B CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 FZR1 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT4 WNT3A LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WIF1 SOST TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand LBP CD36 LY96 TLR1 CD14 GSDMD GSDME S100A9 APOB TLR6 S100A8 TLR2 TLR7 FGB HMGB1 S100A1 FGA FGG TLR4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport ABCB6 ABCB4 SEL1L KCNJ11 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 VCP ABCC2 ABCG8 ABCC6 EIF2S2 EIF2S1 EIF2S3 ABCG5 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 ABCA3 ABCC3 ABCC1 ABCG1 ABCD3 PSMD8 PSMD6 ABCC4 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 ABCD2 ABCA6 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 ABCC5 PEX3 UBC ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 SEM1 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 ABCA12 PEX19 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 GFPT1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 CILP PIK3CA TLR9 PIK3C3 TRIB3 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly SERPINB1 CASP4 CALM3 CALM2 CALM1 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand TLR7 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin FDX1 FDX2 FDXR HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM5D PHF8 UTY KDM4B H4C9 KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 KDM7A KDM3A KDM1A KDM1B KDM4A KDM4C H3C8 KDM5B KDM5A KDM6A PHF2 KDM6B KDM5C KDM3B H3C15 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 FZR1 PLK1 FBXO5 CCNB1 CDC20 CDK1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle CLTC IQGAP1 SH3RF1 VANGL1 ARHGEF7 PIK3R1 RHOV MAP3K11 SPTAN1 MYO9A TPM4 GIT1 TPM3 TXNL1 WASL ARHGAP12 CDC42 DEPDC1B ZNF512B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 PARD6B PAK6 PAK1 CCP110 CEP97 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle DSG1 VANGL1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 ROCK1 TMOD3 TXNL1 PKP4 DDX4 RASAL2 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B EPHA2 WDR6 DST UBXN11 DLG5 PICALM ARHGAP21 TNFAIP1 SEMA4F PTPN13 RND3 NISCH KTN1 CKB CKAP4 PLEKHG5 KCTD13 SCRIB VANGL2 FLOT2 DSP CAV1 CCDC88A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 GPAM MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab ERBIN HSP90AA1 ERBB2 CDC37 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP3 CHMP6 CHMP7 TUBB8 IST1 TUBA8 TUBA1C LEMD2 TUBA1B TUBB8B TUBA1A TUBB2B TUBB2A SPAST CC2D1B TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D CHMP4C TUBA3C CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A TUBB4B TUBB4A SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 CSF1R SHC1 LYN STAT3 CBL INPP5D PIK3R1 IL34 UBA52 GAB3 GRAP2 STAT1 KRAS UBB PTPN11 PIK3CB UBC RPS27A PIK3CD THOC5 SRC YES1 HCK FYN INPPL1 PLCG2 GAB2 PIK3CA CSF1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 BBS2 BBS1 CCT2 CCT8 RAB3IP CCT5 BBIP1 BBS9 CCT4 BBS7 CCT3 TTC8 BBS5 BBS4 MKKS SMO TCP1 SSTR3 LZTFL1 BBS10 BBS12 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACSM6 HADHB MECR ACADL HADHA ACADVL ECHS1 ACADM ACSM3 ACADS HADH SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 HDAC1 NEURL1B DNER HES5 TLE4 APH1A TLE2 HDAC3 DLL4 MIB2 ITCH PSENEN TLE1 DTX1 NCSTN MIB1 DTX2 APH1B HEYL PSEN2 DLK1 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 DTX4 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 ARRB1 RBX1 ARRB2 HIF1A HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 NUMB HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NBEA NOTCH1 CUL1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib ERBIN HSP90AA1 ERBB2 CDC37 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FPGT FCSK GFUS FUOM MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) MYD88 TLR5 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5E NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation FGF19 FGF18 FGFR4 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 KLB FGF20 FGF16 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG1 HRAS SOS1 HBEGF SHC1 NRAS NRG3 EREG NRG4 BTC NRG2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CDKN1A CDKN1B ARID3A E2F1 CDK2 E2F7 E2F8 CCNA2 TP53 CCNA1 CCNE2 CCNE1 ZNF385A CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling RELA NFATC1 MAP3K7 NFKB1 UBA3 UBE2M CDC34 NFATC2 CHUK IKBKB CARD11 MALT1 ITPR1 RELB ITPR2 CLEC7A ITPR3 CARD9 NFKBIA MAP3K14 TAB1 UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PLCG2 PSMD3 PSMD1 CALM1 PYCARD PRKCD PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 TRAF6 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 NFKB2 PSMB6 PSMB7 IL1B PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB TAB3 SKP1 PDPK1 TAB2 CASP8 PPP3R1 UBE2N CUL1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UXS1 UGDH UGP2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events GNAQ ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 GNAT3 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 CAMK2A GNAI3 GNAI1 GNAI2 CALM1 CAMK2G PRKCD PRKCA PLCB4 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 NBEA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle ERBIN ARHGAP26 ARHGEF3 VANGL1 ARHGEF1 ARHGAP32 ARHGEF2 PIK3R2 ARHGEF5 PIK3R1 RHOB ROCK1 CAVIN1 ROCK2 MYO9A ABR RTKN ECT2 ARHGEF28 MCF2 NET1 RHPN2 ARHGDIG SOWAHC STARD8 CIT ARHGEF25 PKN3 TFRC IQGAP3 SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 STOM MCF2L RACGAP1 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis FUT2 FUT1 ABO NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAP2K1 MAP2K2 MAPK3 BRAF DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type MMAB SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors SCARF1 APOB CALR HSP90AA1 HSPH1 HYOU1 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways HBEGF GBP1 FURIN HSP90AB1 HBB ATP6V1H MAPK1 STAM2 CTSG CTNNB1 MET RNF213 MAPK3 STX1A B2M CDH1 MRC1 SRC GBP2 UBE2D2 GBP6 GBP4 HBA2 STX1B NOS2 CBLL1 LTF TLR2 GUCY2C SYT2 NHERF4 GSK3A CALM1 ENO1 SNAP25 SH3KBP1 TRIM27 HSP90AA1 KPNA1 SYT1 CD9 CBL CTNND1 UBA52 STAM DUSP16 VPS33B CORO1A PGK1 HGS RAB5A KPNB1 SV2C SV2B SV2A VAMP1 UBB TXNRD1 MAP2K4 UBC RAB7A RPS27A SH3GL3 UPK1A EPCAM EPS15 SH3GL2 SH3GL1 SFPQ VAMP2 MAP2K7 EEF2 CASP4 MAP2K1 MAP2K2 CALM3 CALM2 PDCD6IP MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB RABGGTA NDRG1 BCL6 PERP TP53I3 BIRC5 TP63 TP73 PPP1R13B TP53 TP53BP2 BCL2L14 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE MTR MTRR SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 PI4KA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K7 FURIN MAP2K1 MAP2K2 CALM1 PDCD6IP CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle PCNA NPM1 YWHAE EML4 YWHAQ CDCA5 MYBL2 NCAPG YWHAG ARPP19 ZNF385A NCAPH YWHAH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A UBE2V2 PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 UBE2N CHMP3 CHMP6 CHMP7 PLK3 CDC7 HSPA2 FBXL18 FBXL7 PHF20 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH PIAS4 POLR2A POLR2B POLR2C POLR2D BRCC3 LYN POLR2E POLR2F POLR2G POLR2H CDKN2B POLR2I POLR2J POLR2K POLR2L BABAM1 CDK7 BABAM2 MNAT1 UIMC1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 RUVBL1 ABL1 WRAP53 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E CLSPN NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 MDM2 MDM4 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 ABRAXAS1 NUP37 ERCC6L RBBP7 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 CHEK2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MLH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 JAK2 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 PPP1CB CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 HJURP RFC5 RMI2 PPP2R2A RFC3 PPME1 GTSE1 RFC4 RMI1 BORA TERT FKBPL RFC2 FBXW11 OPTN TOP3A OBI1 HMMR RPA1 HUS1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B RAD50 TICRR MCM7 RAD51 MCM8 RAD51C GMNN RPA3 RAD17 SKP1 RAD1 CCNA2 ATM CCNA1 MCM3 DNA2 RAD9B MCM4 RHNO1 MCM5 MCM6 ATR RAD9A MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 FKBP6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B HERC2 PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MDC1 MYC YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 PIF1 FIGNL1 GAR1 CTC1 KMT5A TEX12 TEX15 RNF168 NSD2 CENPW CENPX RUVBL2 OIP5 MSH4 MSH5 HSP90AA1 NHP2 ANKRD28 NOP10 SYCP2 CDC25C SYCP1 CDKN1C SYNE2 RB1 SYNE1 CDKN1B PPP6C PPP6R3 CCND3 SMC1B FZR1 MND1 CCND2 E2F1 REC8 E2F2 SYCP3 E2F3 RTEL1 SKP2 CHTF8 DAXX TP53BP1 ATRX STAG3 CDK6 RSF1 TFDP1 DMC1 PSMC3IP CCNE2 TFDP2 MLH3 CDK4 MIS18A NEK11 CCNE1 H2AX PRDM9 DSCC1 SHQ1 CPAP LIG1 DKC1 MAX H2AB1 SYCE3 H2AC19 SYCE2 POLD3 COP1 H2BC26 POLD4 H2AC14 SYCE1 POLD1 H2BC12L SPO11 POLD2 RCC1 CHTF18 H2BC21 SUN2 EP300 SUN1 RNF8 H3-3B STN1 H3C8 TEN1 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 SMARCA5 GSK3B CSNK1A1 PHLDA1 PCBP4 AKT3 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP ZNF141 HDAC1 ZNF382 H2AC20 ZNF547 ZNF418 ZNF224 MBD3 ZNF354A ZNF136 ZNF649 GATAD2B GATAD2A CHD3 SUMO2 UBE2I ZNF778 HDAC2 ZNF454 ZNF28 CBX5 CHD4 ZNF273 SETDB1 ZNF816 ZNF519 ZNF610 ZNF264 ZNF680 TRIM28 MTA2 ZNF30 ZNF257 RBBP4 MTA1 ZNF33A MTA3 RBBP7 ZNF331 H2AX ZNF93 H2AB1 H2AC19 H2BC26 ZNF708 H2AC14 H2BC12L H2BC21 ZNF324 ZNF534 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ZNF320 H2BC17 H2BC12 H2BC13 ZNF669 ZNF765 H2BC14 H2AJ H2BC15 ZNF317 H2BC11 ZNF425 H3C15 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism TCN2 CD320 MCCC2 BTD ACACA PC PCCA HLCS CUBN CBLIF MMAB MCCC1 AMN PCCB MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 PABPN1 EIF4E PAIP1 EIF4B EIF4A3 PABPC1 DIS3L2 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH PECR SLC25A17 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A6 SLC12A3 SLC12A1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 SNU13 DCAF13 NOP14 UTP6 UTP4 KRR1 UTP3 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP2 TRMT112 NOP56 NOP58 GAR1 NHP2 NOP10 RPS14 DKC1 RPS2 RPS9 RPS7 RPS6 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FURIN H2BC1 INS H2AC20 APH1A PSENEN APOA1 NCSTN APOA4 APH1B HSPG2 ADAM10 APOE NPPA SIAH1 PRL CALB1 NAT8B BACE1 APCS TSPAN33 B2M GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI LTF ITM2B UBA52 SIAH2 LYZ FGA CALCA H2AX UBB GSN SEMG1 H2AB1 UBC H2AC19 IAPP H2BC26 H2AC14 RPS27A H2BC12L H2BC21 PRKN TTR H3-3B H3C8 H2AC8 MFGE8 H2AC6 H2AC7 TSPAN14 H2BC17 APP H2BC12 H2BC13 H2BC14 CST3 SAA1 H2BC15 USP9X H2BC11 UBE2L6 H3C15 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB NBEA CALM1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation RELA MAP3K7 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 CARD11 IGKV2D-28 MALT1 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 TRPC1 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK IGLC1 BTRC IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PRKCB HRAS PPP3CA PPP3CB PPP3R1 VAV1 SOS1 NFATC1 PIK3R1 NFKB1 NRAS NFATC2 CHUK CD19 IKBKB FKBP1A PSMD8 PSMD6 PSMD7 DAPP1 RASGRP3 PSMD2 REL NFKBIE PSMD3 CD22 PIK3AP1 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD FBXW11 PTPN6 ADRM1 PPIA PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation IFNA2 IFNA8 TRAF2 IFNA13 IFNA14 IFNA16 IFNA17 TRAF6 IFNA10 IFNA21 IFNB1 IFIH1 TRIM4 CREBBP TBK1 EP300 IRF3 MAVS RNF135 RIGI TRIM25 IKBKE IRF7 IFNA5 TANK SIKE1 IFNA4 IFNA7 IFNA6 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t PGM1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis HSD3B2 HSD3B1 CGA LHB CYP21A2 CYP11B2 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 HHAT VCP IHH SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 DTX4 TBK1 NFKB1 IRF3 NFKBIA NLRP4 DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling IL21R LGALS9 SOS1 HAVCR2 IL15RA PTK2B STAT5A STAT5B IL15 SHC1 IL5 STAT3 IL3RA PIK3R2 INPP5D IL2RB SOS2 PIK3R1 IL9 GRB2 IL9R JAK3 STAT4 JAK2 JAK1 IL2RG STAT1 CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 SYK LCK INPPL1 GAB2 PIK3R3 PIK3CA IL21 IL2RA IL5RA CSF2RB CSF2RA METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins VKORC1L1 UBIAD1 LRP1 RETSAT APOA2 APOM APOA1 TTPA BCO2 APOA4 BCO1 HSPG2 VKORC1 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation LCK AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 ARF1 CD4 ATP6V1H ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors GRIN3A APBA1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D KIF17 GRIN1 DLG1 GRIN2A CASK LIN7A DLG2 LIN7C NBEA DLG3 LRRC7 LIN7B DLG4 NEFL CAMK2G GRIN3B DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation UHRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 DNMT3L H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DBT DLD DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis NCAN CHST15 CSPG4 BGN DCN BCAN VCAN DSEL CHST14 DSE UST CSPG5 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 KPNA2 H2BC15 TP53 H2BC11 ATM UBE2N PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CDK2 CCNE2 RB1 CCNE1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration ITGA5 ITGBL1 MMP13 AKT1 AKT2 CBFB AKT3 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry AGRN FURIN NCL EGFR GPC1 LY96 GPC3 GPC2 CD14 GPC5 RAB5B GPC4 RAB5C GPC6 CX3CR1 HSPG2 IGF1R SDC1 RAB5A SDC4 SDC2 SDC3 TLR4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED19 MED18 SREBF2 MED11 WNT1 RELA MED9 MED29 MED28 MED22 TGFB1 MED21 CDK19 MBD3 MED13L ANGPTL4 LPL GATAD2B GATAD2A CDK8 SMAD1 SMAD4 LEP CHD4 CIDEA SMARCD3 CCND3 MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MTA3 CARM1 EBF2 RBBP7 BMP7 CDK4 KLF4 EP300 MED1 MED30 MED31 MED8 MED4 MED6 MED7 ELOVL3 CEBPA HNRNPU RXRA NFKB1 HDAC1 KLF5 HDAC3 CEBPB TBL1X PCK1 NCOA1 EGR2 FABP4 NCOR2 COX7A1 CHD3 NCOR1 TBL1XR1 PLIN1 HDAC2 THRAP3 FAM120B PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC ADIPOQ HELZ2 MED16 MED15 CREBBP MED17 CHD9 MED12 MED14 MED13 TNF MED10 EBF1 WNT10B NR2F2 ADIRF SLC2A4 ZNF638 TGS1 CEBPD ZNF467 MED27 MED26 MED23 MED25 MED24 MED20 PPARG PPARA DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction SOS1 CRK STAT5A STAT5B STAT3 PIK3R2 PIK3R1 PDGFB NRAS PLCG1 STAT1 PTPN11 PIK3CB RAPGEF1 NCK2 NCK1 RASA1 SRC PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling JUN GNG13 ZNF217 FKBP5 EBAG9 GNB2 KDM4B YY1 GNB1 GNB4 DDX5 GNB3 GNB5 GNGT1 GPAM GNGT2 SPHK1 GNG3 CXCL12 ESR1 GNG2 GNG5 GNG4 GNG7 GNG8 POU2F1 NOS3 TBP HSP90AA1 EGF EGFR CDKN1B S1PR3 CARM1 H2AX H2AB1 H2AC19 MMP2 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 MED1 H2AC8 PRKCZ H2AC6 CTSD H2AC7 HRAS H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 MMP3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 PIK3R3 PIK3CA CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 HBEGF H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 HDAC1 NRAS H2AC20 HSP90AB1 KDM1A MAPK1 GNAT3 CCND1 PTGES3 NRIP1 FKBP4 NCOA1 SRF MAPK3 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 ESR2 AGO2 SRC TNRC6A TNRC6B GNAI3 XPO1 GNAI1 GNAI2 AKT1 CALM1 AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 MMP9 KANK1 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG KAT2B FOXA1 ZDHHC7 TLE3 KPNA2 PPID TGFA USF1 CAV2 FOS FOXO3 GREB1 ELK1 IGF1R GNG10 CHD1 PTK2 MMP7 EREG PGR TFF3 UHMK1 TFF1 BTC ZDHHC21 CAV1 GNG12 CXXC5 EPGN AKT3 GNG11 USF2 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors HRH3 HRH2 HRH4 HRH1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters SLC24A2 SLC24A3 SLC41A2 SLC41A1 SLC30A10 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 CP SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC40A1 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC8A1 SLC8B1 SLC24A1 SLC8A2 HEPH SLC24A4 SLC11A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SRI SLC9A8 SLC9A9 SLC9A1 SLC24A5 SLC39A4 SLC8A3 SLC11A2 CALM1 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation POLE4 POLE POLE2 PRIM2 POLE3 PRIM1 POLA1 POLA2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 CAVIN1 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules LRFN1 PTPRS PTPRF GRIA1 GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG3 RTN3 DLG4 FLOT1 LRFN3 FLOT2 PTPRD GRIA3 LRFN2 GRIA4 LRFN4 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA PLA2G2D MIGA1 PLD1 PLA2G2E DDHD2 AGPAT2 PLA2G5 DDHD1 PLA2R1 PLA2G10 GPD1 GPD1L PLD6 GPAM PLA2G2A GPAT2 LPCAT1 PLA2G4A PLD2 ALPI GPD2 GNPAT LIPI ACP6 LIPH PLA2G12A PLA2G4D GPAT4 PLA2G4B GPAT3 AGPAT5 PLA2G1B LPCAT4 AGPAT1 AGPAT3 AGPAT4 LCLAT1 PLA2G2F MIGA2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism ACSL1 FADS1 ELOVL5 ELOVL2 ABCD1 ELOVL3 ELOVL1 FADS2 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity HTT HDAC1 HDAC3 GPS2 SIN3A LBR HIPK2 PRKACA TBL1X AURKB FOXG1 NCOR2 TNRC6C MOV10 NCOR1 AGO3 TBL1XR1 AGO4 CAMK2B AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A CAMK4 CALM1 CAMK2G SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections IFNA2 IFNA8 RELA IFNA13 IFNA14 IFNA16 SAP30L IFNA17 NPM1 ITCH IFNA10 IFNA21 IFNB1 ISG15 NR3C1 PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP YWHAE VPS41 NPIPB3 VPS45 NMI PARP10 PARP6 SFTPD CHD4 IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 MTA2 VPS33B RIPK3 REST KPNB1 FNTA CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A VAV1 UBE2N CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 PTGES3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 FKBP4 OST4 EDEM2 MOGS SDC4 ZDHHC11 IFNGR1 DDOST SDC2 IFNGR2 MGAT4C SDC3 ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 SUMO1 GPC5 GPC4 GPC6 KEAP1 RBX1 TRIM25 SDC1 VHL ISCU BTK IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TLR8 KPNA2 MAP3K7 VCP NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA MAVS TAB1 GJA1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C PYCARD NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 TRAF3 RANBP2 TRAF6 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 BECN1 NUP50 NUP35 RBBP4 NUP54 NUP37 NOD1 RBBP7 NOD2 NCK1 AKT2 PDPK1 RPS27 ITGB1 TLR9 PIK3C3 SOS1 SNRPD2 SNRPD1 SNRPD3 PIK3R4 BST2 PRMT1 CHUK TJP1 PCBP2 PTPN11 CASP1 JAK2 ZCRB1 SYK SNRPG SNRPE PPIH PPIG SNRPF AP2A1 SNRPB AP2A2 DDX5 AP2M1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 SAR1B IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 TLR1 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 TLR2 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 SAP18 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 IGLC2 S1PR1 JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 IGLV3-19 MTA3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 RPS4Y1 IGLV3-1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 RPS17 IGKC RPS15A IGKV1-39 IGLV3-21 RPS16 RPS19 IGKV1-33 BRD4 RPS18 RPS3 CRBN RPS2 IGLC7 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 RPS13 IGLC6 RPS12 IGKV1-5 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 PDCD1 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 HLA-H HLA-B HLA-C ATG14 HDAC1 HLA-F HSP90AB1 HLA-G HLA-E YWHAB FKBP1A IKBKE AKT1 IRF7 NUP214 SFN YWHAZ UBA52 TUBB UBB UBC RPS27A UBE2V1 PSMC6 CAV1 FURIN ATP1B3 ROCK1 ATP1B2 ROCK2 ATP1B1 CUL3 MBD3 STAT1 GATAD2B GATAD2A ZBP1 SEC23A TBK1 B2M IRF3 STING1 HLA-A FXYD4 FXYD3 FXYD2 FXYD1 PALS1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 UVRAG ANO5 MAP1LC3B ANO2 ANO3 HSP90AA1 ANO1 RB1 ATP1A4 ATP1A3 ATP1A2 FNTB SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 EP300 IL6R RUNX1 NRP1 MASP1 NFKB1 SRPK1 KDM1A HSPG2 ITGA4 AGRN CHD3 HDAC2 ST6GALNAC2 SIKE1 GSK3B CSNK1A1 ST6GAL1 ST6GALNAC3 ST6GALNAC4 ARID4B SAP30 CREBBP SP1 ST3GAL4 NFE2L2 BCL2L1 ST3GAL1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 TAB3 TAB2 CTSL IFNA5 IFNA4 IFNA7 IFNA6 AKT3 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib ERBIN HSP90AA1 ERBB2 CDC37 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines STAT6 TBK1 STING1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A GALNS BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins KPNA7 KPNA4 KPNA5 KPNA3 RPN2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 SPCS2 PRKG2 SPCS1 OST4 SEC11A SEC11C DDOST TMEM258 DAD1 OSTC CANX CALR ACOT2 STT3A STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 KPNA1 IPO7 DNAJB11 P4HA1 UBA52 P4HA2 P4HA3 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UBB UBC DNAJC3 RPS27A KPNA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling CAP1 ABL2 CLASP1 CLASP2 SLIT2 ABL1 ROBO1 CAP2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 LEF1 SOX10 SMARCC1 CTNNB1 SMARCC2 GPR143 ACTB SMARCE1 ACTL6A SYTL2 PMEL TFAP2A MYO5A RAB27A TYR AKT2 MYRIP MAPK14 DPF1 BCL7A DPF2 DCT BCL7C IRF4 BCL7B DPF3 SMARCA2 SMARCA4 TYRP1 MLANA USF1 MLPH SS18L1 ARID1A ARID1B ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs PRKAG3 CAMKK2 PRKAB2 PRKAA1 PRKAA2 CALM1 PRKAG1 PRKAB1 PRKAG2 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 TXNRD1 RPS17 SARS1 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A PAPSS2 RPL6 PAPSS1 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 EPRS1 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2A UBE2C UBE2L3 UBE2E1 UBE2D1 UBE2W USP7 USP5 UBE2S UBA52 UBA1 UBE2K UBE2Z CDC34 UBE2Q2 UBE2E3 UBB UBE2R2 UBC UCHL3 RPS27A UBE2T OTULIN UBA6 UBE2D2 USP9X UBE2H UBE2G1 UBE2G2 UBE2B PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds CYB5B CYP51A1 CYP4B1 CYB5R3 CES3 CYP27A1 CYP39A1 CYP3A5 AOC1 CYP2A13 CES1 FMO3 CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP7A1 CYP1B1 CYP2C19 CYP2D6 CMBL ALDH3A1 FDXR POR CES2 MAOB MTARC2 MAOA CYP8B1 MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP46A1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 RXRA ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 ARNT2 PTGES3 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR CYP4F12 PTGIS PTGS1 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP4F11 AIP CYP11B1 TBXAS1 ADH1C ADH1A ADH4 PAOX ALDH1A1 ALDH2 CYP3A4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR2 TGFB1 TGFBR1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) GP5 SOS1 GP9 CRK SHC1 MPL FN1 GP1BA THPO RASGRP2 RASGRP1 RAP1B RAP1A CSK ADRA2C FGB ADRA2B RAPGEF3 FGA ADRA2A RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 F2 AKT1 PTK2 ITGB3 ITGA2B GP1BB SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R HRAS SOS1 IGF2 IGF1 IGF1R NRAS GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 TJP1 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose DPM3 DPM1 DPM2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH JUN SEL1L WWC1 NEURL1B DLGAP5 HES5 PTCRA MIB2 ITCH PBX1 MIB1 HEYL ATP2A3 NEURL1 TACC3 MAMLD1 ATP2A2 ATP2A1 YBX1 ELANE NUMB PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC MAML2 NOTCH2NLB MAML1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC1 GZMB APH1A DLL4 PSENEN NCSTN APH1B CCND1 PSEN2 ADAM10 PSEN1 RBPJ TMED2 FCER2 TNRC6C MOV10 RFNG MFNG AGO3 B4GALT1 MDK AGO4 ACTA2 MYC AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 HIF1A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 KAT2B KAT2A HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 NBEA FURIN DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 STAT1 CDK8 SMAD3 DTX4 JAG2 ADAM17 ARRB1 ARRB2 WWP2 EGF EGFR HDAC5 PLXND1 HDAC8 HDAC9 HDAC6 HDAC7 E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 HDAC10 EP300 HDAC11 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 TBL1X NCOR2 FABP7 NCOR1 TBL1XR1 SNW1 HDAC4 HDAC2 FLT4 HES1 CCNC CREBBP ST3GAL4 LFNG ST3GAL6 JAG1 ST3GAL3 SEM1 DLL1 SKP1 CUL1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA NGFR LINGO1 NGF MAG OMG RTN4 MCF2 RHOA DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis JUN PRDX2 PRDX1 CDK5 CDC25C CDKN2A CDC25B CDC25A C1QBP APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 TP53 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) RPS6KA1 CLTC CLTA AP2A1 AP2A2 NGF AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB VGF EP300 JUNB HRAS FRS2 MAP2K1 CRKL MAP2K2 PIK3CA SOS1 DUSP4 DUSP3 VRK3 DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 ADCYAP1 ADCYAP1R1 YWHAB SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA ATF1 BRAF MAP2K5 RAPGEF1 MAPKAPK3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTRK2 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin KLF4 INS GCG PCSK1 BCHE IGF1 SPCS3 SPCS2 LEP SPCS1 SEC11A UCN SEC11C ACHE MBOAT4 PLA2G7 CRHR2 GH1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation BTRC DDB1 COPS7B COPS7A CUL4A COPS3 LRR1 COPS6 CCNF COPS5 COPS8 FBXO7 FBXO9 WSB1 FBXO2 CDKN1A FBXL18 FBXL7 SQSTM1 FBXL8 FBXL4 DTL LRRC41 UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 HIF3A PSMD7 ELOB ELOC SOCS2 PSMD2 KLHL2 RBX1 SOCS6 KLHL3 PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL KLHL9 SPSB2 SPSB1 DCAF8 KBTBD6 DCAF5 KLHL5 DCAF4 PSMA5 DCAF6 PSMA6 WSB2 PSMA3 KBTBD7 OBSL1 PSMA4 KBTBD8 DCUN1D5 PSMA1 SPSB4 DCUN1D3 DCUN1D4 PSMA2 DCUN1D1 DCUN1D2 FBXO27 UBA52 COMMD8 PUM2 NPLOC4 PSMD12 DDA1 PSMD11 ANKRD9 FBXO21 UBXN7 PSMD14 COMMD2 FBXO22 COMMD1 PSMD13 COMMD6 COMMD7 PSMA7 COMMD4 FBXW12 COMMD5 PSMB6 SPSB3 FBXW8 PSMB7 CCDC8 CISH PSMB4 FBXO17 CUL9 DPP3 UFD1 PSMB5 FBXO15 UBD NAE1 DCAF7 UBB SOCS5 PSMB2 WDTC1 PSMB3 LMO7 CCDC22 FBXO10 COMMD10 UCHL3 FBXO11 UBC TULP4 FBXO4 PSMB1 KLHL41 DCAF16 KCTD7 DCAF17 FBXO6 DDB2 RPS27A FEM1C DCAF10 KLHL42 DCAF11 FEM1A FBXW4 CUL7 FEM1B FBXW5 CUL5 NEURL2 NEDD8 FBXW10 ADRM1 ERCC8 FBXW7 PSMC5 FBXW9 PSMC6 KLHL11 PSMC3 PSMC4 FBXW2 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 FBXL3 UBA3 FBXL5 MUL1 UBE2M GPS1 KBTBD13 CUL3 VCP COPS4 COPS2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 ASB16 FBXL20 ASB10 WDR5 SENP8 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 SKP2 RBBP5 ASB1 RBBP7 COP1 SOCS3 COMMD9 FBXO32 BIRC5 DCAF13 COMMD3 KCTD6 AMER1 UBE2D1 BRCA1 CAND1 NFE2L2 FBXW11 FBXL21P PALB2 SEM1 SKP1 CUL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC MMACHC RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle HNRNPC CCT6A CCT7 RBMX DBN1 HSP90AA1 CDC37 HSP90AB1 TWF1 CCT2 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B CUL3 PHIP TXNL1 SRRM1 TRA2B ACTG1 MYO6 STK38 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation TRAF2 RELA MAP3K7 NFKB1 TRAF6 UBA52 USP14 NFKB2 CHUK NOD1 NKIRAS1 NOD2 NKIRAS2 USP18 IKBKG UBB IKBIP RIPK2 IKBKB UBC RPS27A ALPK1 LRRC14 NLRX1 IRAK1 UBE2V1 NLRC5 NFKBIA AGER IRAK2 TIFA S100A12 TAB1 APP S100B SAA1 TAB3 TAB2 HMGB1 TP53 NFKBIB CASP8 UBE2N THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 TBXA2R GNG7 AAMP GNA11 GNGT1 GNG8 GNA13 GNGT2 GNG10 GNG12 GNG11 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes SRPRB ATP6V0D1 TPP1 CXXC1 PREB HDGF PPP2R5B KDELR3 ACADVL SHC1 ADD1 PDIA6 DNAJB11 DCTN1 SERP1 WFS1 SEC31A TLN1 DNAJC3 EXTL2 CUL7 FKBP14 GOSR2 MYDGF EXTL3 PLA2G4B HYOU1 EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 GSK3A EDEM1 WIPI1 YIF1A SYVN1 ARFGAP1 PDIA5 CTDSP2 SRPRA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 FGF18 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A TP53 ING2 PIP4K2B MAP2K6 PIP4P1 EP300 PIP4K2C ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B PPP2R1A TICAM1 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA PPP2CB TLR3 MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes CREBBP TALDO1 MAFG PGD NFE2L2 TKT EP300 G6PD CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL STAT3 GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 HDAC3 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 GBA1 ACTB CCNE1 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 GNG10 GNG12 GNG11 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells FGF10 ONECUT3 ONECUT1 PDX1 NKX6-1 PTF1A HNF1B RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G NFIX POLR3H SSB POLR2K NFIA POLR3K POLR2L NFIB NFIC POLR1C POLR1D ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription DHFR PCNA ORC1 TK1 CDT1 CDC6 HDAC1 CDK1 RRM2 E2F1 RBBP4 CDC45 FBXO5 TFDP1 TFDP2 LIN54 LIN37 CCNE1 LIN9 POLA1 TYMS LIN52 E2F4 E2F5 E2F6 CCNA1 RBL2 RBL1 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids CYP2F1 CYP4A22 CYP4B1 CYP2D6 CYP4F12 CYP4F22 CYP4F3 CYP4F8 CYP2A13 CYP2B6 CYP2J2 CYP4F2 CYP4A11 CYP2A7 CYP4F11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates MUS81 FIRRM BLM SLX4 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS HRAS SOS1 NTF4 NTRK2 BDNF NRAS DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency MCCC2 PC ACACA PCCA HLCS MCCC1 PCCB CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants ALK VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly CASP5 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO3 FMO1 FMO2 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation DRG2 RCCD1 ZC3H15 JMJD6 ASPH U2AF2 RIOX2 RPS6 F9 RPL8 RWDD1 JMJD4 KDM8 RPS23 JMJD7 RIOX1 ETF1 OGFOD1 RPL27A DRG1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR2 TGFB1 TGFBR1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP RBPJ MAML2 MAML1 KAT2B ONECUT3 KAT2A ONECUT1 HES1 SNW1 EP300 NEUROG3 HNF1B MAMLD1 MAML3 NOTCH1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 TACC3 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 CUL1 NOTCH4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN52 HDAC1 CDK1 E2F4 E2F5 E2F1 RBBP4 CCNA2 TFDP1 TFDP2 LIN54 LIN37 MYBL2 LIN9 RBL2 RBL1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2E1 CYP3A7 RXRA CYP51A1 CYP2F1 CYP4B1 CYP2W1 ARNT2 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP27A1 CYP39A1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR PTGIS CYP4F12 CYP3A5 CYP2A13 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP7A1 CYP1A1 CYP1B1 CYP2C19 CYP4F11 CYP11B1 TBXAS1 CYP2D6 FDXR POR CYP8B1 CYP2C18 CYP2B6 CYP46A1 CYP2S1 CYP4V2 FDX1 CYP3A4 CYP3A43 FDX2 CYP2A7 CYP2A6 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions CACNG2 CACNG3 CACNG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 STX1B CACNG8 DLG4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI PLA2G2D PLA2G2E MBOAT7 PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4C PLAAT3 PLA2G2A PLA2G1B PLBD1 PLA2G2F PLA2G4A DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus RB1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME3 ME2 VDAC1 WDR26 PDHB RMND5B PC LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 LDHC MPC1 PDK1 LDHB MPC2 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GLO1 GID4 GID8 UBC FAHD1 MPC1L RPS27A LDHAL6A LDHAL6B PDK4 GPT DLD SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT KIT DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 STRAP HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 TFAP2A HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A ARID1A FOXA2 TGIF2 EED RB1 RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX KLF4 H2AB1 SP1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis CYB5B SPTLC1 OSBP SPNS2 SPTLC2 SPTLC3 CSNK1G2 VAPA ABCG2 KDSR MFSD2B SPHK1 FA2H ORMDL2 ORMDL3 SPTSSB DEGS1 SPTSSA DEGS2 SPHK2 SAMD8 SGMS1 CERS3 ORMDL1 SGMS2 CERS4 ABCC1 CERS5 CERS6 CERS1 CERS2 PPM1L VAPB PRKD3 PRKD2 PRKD1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development HNF1A MAFA RFX6 INSM1 FOXA3 GCK ONECUT3 ONECUT1 HES1 PDX1 INS NKX6-1 PTF1A PAX6 SLC2A2 MAMLD1 RBPJ CREBBP MAML2 IAPP FGF10 MAML1 KAT2B KAT2A FOXO1 EP300 SNW1 AKT2 NEUROG3 HNF1B HNF4G MAML3 AKT1 FOXA2 NEUROD1 NOTCH1 NKX2-2 AKT3 PAX4 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PRKCA FES SOS1 STAT5A STAT5B PTPRU SH2B2 LYN CMA1 STAT3 PIK3R2 CBL FER PIK3R1 TEC GRAP NRAS GRAP2 JAK2 STAT1 SOCS1 CHEK1 MMP9 PTPN11 PTPN6 GRB10 YES1 RAC1 HRAS LCK FYN KIT SOCS6 SH2B3 GRB7 GAB2 PIK3R3 PIK3CA VAV1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 YWHAE YWHAQ YWHAG ZNF385A YWHAH BTRC UBE2V2 UBE2N HERC2 PLK3 CDKN1A CDKN2A CDC7 CDK2 CDC45 MDC1 PHF20 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 PSMD1 SFN YWHAZ PSMA5 PSMA6 PIAS4 PSMA3 PSMA4 BRCC3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 BABAM1 PSMB6 BABAM2 PSMB7 PSMB4 UIMC1 PSMB5 CSNK1E UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 CCNB2 CDC25A PKMYT1 WEE1 CLSPN MDM2 MDM4 NUP107 NUP160 RNF168 NUP85 NSD2 NUP43 RANBP2 SEC13 CDC25C NUP133 CDKN1B ABRAXAS1 TP53BP1 NUP37 ERCC6L ZWILCH BUB1B CCNE2 CDC20 NEK11 PPP1CC CCNE1 PPP2R1B H2AX PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 COP1 H2BC26 SGO2 H2BC12L DYNC1LI2 H2BC21 ZW10 MAD1L1 RNF8 CDCA8 PMF1 SKA1 CHEK2 SKA2 DSN1 H2BC17 H2BC12 H2BC13 H2BC14 RCC2 H2BC15 NDC80 ZWINT H2BC11 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 GSK3B CSNK1A1 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 GTSE1 RFC4 RMI1 PCBP4 RFC2 FBXW11 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 MCM7 MCM8 RPA3 SKP1 RAD17 RAD1 CCNA2 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 CLIP1 CUL1 ORC5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25C CDC25A CDC7 CDK2 CDC45 CHEK1 ATRIP CLSPN RFC5 RFC3 RFC4 RFC2 MCM10 RPA1 DBF4 HUS1 RPA2 MCM7 MCM8 RPA3 RAD17 RAD1 MCM3 MCM4 RAD9B MCM5 MCM6 ATR MCM2 RAD9A ORC5 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B SLC22A2 SLC22A1 MAOA PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination FZD5 FZD4 UBC FZD6 RPS27A USP8 FZD8 UBA52 RSPO3 WNT3A LRP5 RNF43 ZNRF3 RSPO2 RSPO1 LGR6 LRP6 LGR5 RSPO4 LGR4 UBB RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c ALG6 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest SFN PCNA CCNB1 EP300 PRMT1 CDC25C AURKA CDK1 E2F4 BAX TP53 CARM1 TFDP1 TFDP2 GADD45A RBL2 RBL1 ZNF385A OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism PM20D1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 MMR%REACTOME%R-HSA-5358508.3 MMR LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB NBEA CALM1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 KPNA5 ARIH1 KPNA3 PIN1 EIF2AK2 ISG15 MAPK3 STAT1 EIF4E IRF3 RIGI NUP205 POM121 NUP107 TRIM25 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 UBE2E1 NUP88 NUP43 RAE1 NEDD4 KPNA1 NDC1 RANBP2 SEC13 UBA52 PLCG1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 NUP35 NUP54 NUP37 JAK1 KPNB1 USP18 UBB EIF4E3 IFIT1 PPM1B EIF4E2 UBC FLNB MX2 RPS27A MX1 EIF4G3 EIF4G2 UBA7 EIF4A2 EIF4A1 KPNA2 EIF4G1 UBE2L6 EIF4A3 HERC5 UBE2N MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 HSPB1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 HSPA1A EIF4G1 PSMD2 PSMD3 PSMD1 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors LTB4R2 GPR17 CYSLTR1 CYSLTR2 LTB4R NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants ALK CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes CREBBP CITED2 BBC3 STK11 BCL6 FOXO1 EP300 NFYA NFYB NFYC BCL2L11 FASLG FOXO3 PINK1 FOXO4 DDIT3 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 TSPOAP1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus NEURL1B UBA52 DNER APH1A DLL4 MIB2 ITCH PSENEN DTX1 NCSTN MIB1 DTX2 APH1B NUMB PSEN2 DLK1 NEURL1 ADAM10 CNTN1 PSEN1 UBB UBC RPS27A DTX4 JAG2 JAG1 ADAM17 DLL1 ARRB1 ARRB2 NOTCH1 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis NKX2-5 LEF1 ISL1 CTNNB1 SRF KAT5 FOXO4 SMAD1 SMAD4 HEY1 MEF2C KAT2A HAND2 MESP1 HEY2 GATA6 TBXT TBX20 SMYD1 TBX1 EOMES MYOCD HAND1 LDB1 TBX5 WDR5 GATA4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 SERPINB13 CTSV SOCS3 CTSL CTSK CBFB SOCS4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 APOB S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 GSDMD BIRC3 GSDME USP14 BTRC TLR7 RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 HSP90B1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 LGMN MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB UNC93B1 SIGIRR TLR3 IRAK3 MEF2C CTSS UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 CNPY3 SAA1 TAB3 TLR8 SKP1 TAB2 CTSB TP53 NFKBIB FOS CTSV ELK1 CTSL CTSK MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 ABCB6 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 EGF EGFR NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 TACC3 PSEN1 UBB UBC RPS27A YBX1 JAG2 JAG1 DLL1 NOTCH3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose PMM1 MPI HK1 GMPPB PMM2 GMPPA PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 RBBP4 HLA-DRB5 TRAV19 RBBP5 HLA-DRB4 RBBP7 HLA-DPB1 TRAV8-4 HLA-DRA CDK4 HLA-DRB3 CD4 HLA-DRB1 H2AX HLA-DQB2 H2AB1 HLA-DQB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PTPN11 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 CSK PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 PTPN6 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions CD47 SIRPB1 PTK2B SIRPA FYB1 SIRPG PTPN6 PTK2 SKAP2 TYROBP PTPN11 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFAM TFB2M NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 GNGT1 RHOA GNGT2 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PDPK1 GNG10 AKT1 GNG12 AKT3 GNG11 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ2 KCNJ4 KCNJ14 KCNJ12 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP TXNIP SIRT1 KAT2B SIRT3 FOXO3 FOXO1 EP300 TXN FOXO4 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PALS1 PATJ TJP1 CRB3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 LYN EPO EPOR IRS2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP1 HLA-H PIK3R4 HLA-B SEC13 HLA-C ATG14 HLA-F HLA-G HLA-E BECN1 HSPA5 SEC24D PDIA3 SEC24C TAP2 SAR1B SEC31A TAP1 TAPBP CANX CALR SEC23A B2M HLA-A SEC24B SEC24A ERAP2 PIK3C3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade FRAT2 APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 FRAT1 PPP2R1A PPP2R5E PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 PTK6 STAT3 SOCS3 STAP2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy CETN1 PARK7 UBC RNASE1 GFAP CFTR PLIN3 RPS27A HSP90AA1 HSPA8 UBA52 ARL13B HSP90AB1 HBB HDAC6 PCNT EEF1A1 PLIN2 LAMP2 IFT88 UBB SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome DDX5 ZCRB1 VHL RB1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System KCNJ8 AP2A1 KCNJ11 ABCC8 ABCC9 ADCY9 NTRK3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT RTN3 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 DBNL KCNK6 KCNK7 KCNK1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 GRM1 GRM5 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 FLOT1 FLOT2 ARHGEF9 EPB41L3 GJC1 GJA10 GJD2 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 KCNG1 KCNG2 BCHE KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 PRKCA KCNK17 KCNK18 KCNQ1 KCNQ2 KCNQ3 SNAP25 KCNQ4 RAB3A KCNQ5 SLC32A1 KCNV1 SYT1 SLC6A13 KCNV2 ABAT KCNN1 KCNN3 SLC6A1 KCNN4 CPLX1 RIMS1 KCNF1 KCNC1 ALDH5A1 KCNK9 DNAJC5 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 GIT1 KCNAB1 KCNAB2 KCNAB3 KCNA10 IL1RAPL1 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 HSPA8 KCNK2 VAMP2 KCNK3 HCN2 KCNK4 HCN1 SLITRK3 CAMKK1 CAMKK2 SLITRK5 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 SYT2 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 KCNN2 PTPRF SYN3 SYN2 HRAS SLC6A11 PDPK1 PTPRS ARL6IP5 HOMER3 CACNA2D1 CACNA2D3 EPB41 STXBP1 EPB41L5 NRAS EPB41L2 HOMER1 HOMER2 CHAT PPFIBP1 PPFIBP2 GRIP1 MAPK1 GNAT3 SLC6A4 PANX1 CHRNB2 PANX2 NSF SIPA1L1 CHRNB4 DLGAP1 CHRNB3 GABRG3 DLGAP3 DLGAP2 GRIP2 GABRG2 SLC18A3 DLGAP4 CHRNA1 BEGAIN CHRNA3 SLC17A7 CHRNA2 MAPK3 APBA3 CHRNA5 APBA2 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 SHARPIN GRIK4 LRRC4B GRIK1 SYT9 GRIK2 GRIA1 SYT7 GABRR3 LRRTM3 CAMK2B GABRR2 GRIA2 LRRTM4 GABRR1 LRRTM1 CAMK2D LRRTM2 NPTN SRC ACTN2 HTR3E IL1RAPL2 HTR3C SHANK3 CAMK2A HTR3D NRG1 SHANK2 GRIN2C HTR3A SHANK1 GRIN2B HTR3B NLGN3 PICK1 NRGN NLGN1 GRIN2D GNAI3 NLGN2 AKAP5 GRIN1 NRXN1 GNAI1 DLG1 NRXN3 GRIN2A NRXN2 NCALD GNAI2 DLG2 SLITRK2 CHRND DLG3 SLITRK1 LRRC7 GLRA1 SLITRK4 DLG4 CACNG8 SLITRK6 NEFL GLRA2 PDLIM5 CALM1 GLRA3 NLGN4Y CHRNG CAMK2G NLGN4X SYT10 CHRNE SYT12 CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling JUN NTRK3 NTF3 PDGFB IRAK1 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PDGFRA RAC1 KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 ESR2 HDAC2 SRC NR4A1 NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 GSK3B IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis IRF1 IRF2 CYCS CHMP3 CHMP6 CHMP7 BAK1 ELANE GZMB GSDMD GSDME BAX TP63 IL18 IL1A IL1B CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A HMGB1 TP53 CASP5 CASP1 CASP4 CASP3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein BID BAK1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 POLB LIG3 APEX1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine CTH FMO1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 TST ETHE1 SLC25A10 CDO1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 GCGR GNGT1 GCG GNGT2 GIP GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCYAP1 ADCYAP1R1 GNG10 GNG12 GNG11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TFAP2A CDKN1A TFAP2C MYC DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG3 PPARGC1A MAPK12 PRKAB2 PRKAA2 MAPK14 MAPK11 PRKAG1 PRKAB1 PRKAG2 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 FAM13B WIPF1 WIPF2 CYFIP2 WIPF3 ARHGAP44 PREX2 DOCK11 ARHGDIA NISCH RALBP1 ARHGAP45 SPATA13 ARHGEF25 CIT IQGAP1 PLD1 FGD5 IQGAP2 CHN2 IQGAP3 ARHGAP22 FARP2 ARHGAP20 SRGAP3 SRGAP1 ARHGAP29 ARHGAP27 ARHGAP24 PKN2 ARHGAP33 PKN1 ARHGAP31 FAM13A ARHGAP30 DOCK6 ARHGAP9 DOCK9 DOCK8 DOCK7 WASL ARHGAP4 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARHGAP10 CDC42EP4 TRIO RASGRF2 WAS PLEKHG6 PARD6A CHN1 PAK6 PREX1 SH3BP1 MCF2L PAK3 RAC1 WASF3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 SRGAP2 ARHGEF10 CDC42BPA DEF6 PLEKHG2 KTN1 ARHGEF15 DLC1 PIK3R3 ARHGEF19 PIK3CA DIAPH3 ARHGEF18 ITGB1 VAV1 VAV2 TIAM2 TIAM1 SOS1 ARHGEF4 ARHGEF7 PIK3R2 SOS2 PIK3R1 ARHGEF5 NGEF ARHGEF6 KALRN GNA13 ABR SYDE2 ECT2 ARHGEF39 MCF2 ARHGAP12 PLD2 CDC42 ARHGAP25 ARHGAP23 DOCK5 DOCK4 FMNL1 DOCK3 LAMTOR1 ALS2 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 ARHGAP42 BAIAP2L1 OPHN1 ARHGDIB EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PAK1 RACGAP1 NHS ABL2 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 GIT2 CAV1 MCAM SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 POU2F1 TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP MAPK1 CSTF3 CSTF2 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 SNRPB SRSF9 RBM8A CPSF4 CHTOP CPSF1 ALYREF CPSF3 CPSF2 YBX1 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants FLT3 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC YWHAE YWHAQ YWHAG YWHAH TRAF2 TNFSF10 UNC5A KPNA1 DAPK1 UNC5B DAPK2 DAPK3 FADD BIRC2 CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 E2F1 APPL1 DFFB DFFA DBNL ACIN1 TFDP1 KPNB1 TFDP2 GAS2 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 ARHGAP10 TICAM1 PKP1 LY96 AKT2 BMF BMX STK24 STK26 AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 PPP3R1 TP53BP2 DNM1L DSP OMA1 OCLN OPA1 DSG1 DSG3 TNFRSF10B TNFRSF10A PLEC STAT3 DYNLL1 UACA ADD1 BAK1 GZMB CDKN2A MAGED1 DYNLL2 MAPK1 PPP1R13B MAPK8 CTNNB1 BCL2L11 TJP1 FAS FASLG MAPK3 BAD PMAIP1 CDH1 YWHAB SATB1 PSMD8 PSMD6 PSMD7 PSMD2 CASP6 PSMD3 AKT1 PSMD1 PRKCD APC SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BAX PSMD13 TP63 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC BBC3 BCL2 DSG2 PSMB1 RPS27A BCL2L1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TP73 TP53 PAK2 PTK2 CASP9 CASP7 APAF1 DIABLO AKT3 CASP3 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 CYP2U1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CD36 ITGB5 CYBB CYBA ITGAV INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF28P SCOC SYS1 KDELR1 GOLIM4 KDELR3 GCC2 GCC1 RAB43 RAB41 GOLGA5 KIF5C GOLGA1 ARFIP2 KIF21A KIF21B RHOBTB3 KIFAP3 KLC1 COG8 KLC4 COG7 KLC3 COG6 KLC2 COG5 COG4 COG3 COG2 COG1 RINT1 RAB30 RAB36 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 ARL1 KIF3B SEC22B MAN2A2 VTI1A KIF3C RAB9A RAB6B RAB9B KIF5B RAB39A KIF5A KIF18B KIF4B ALPP KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 M6PR MAN1A2 KIF13B TMED3 VPS45 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 KIF6 BET1L STX5 KIF27 COPZ1 RAB33B KIF9 KIFC2 KIFC1 NAA35 NAA38 VAMP4 PAFAH1B3 ARF5 NAPA GBF1 TGOLN2 NAPB NBAS TMF1 RAB6A STX16 RAB1A STX18 RAB1B GOSR1 NAPG STX10 CYTH3 ARFRP1 CYTH2 GALNT1 CYTH4 CUX1 VPS51 VPS53 VPS52 MAN1C1 SNAP29 BNIP1 ARFGAP3 STX6 ARFGAP2 VPS54 DYNC1LI1 CAPZB CYTH1 RIC1 DYNC1LI2 GALNT2 ARCN1 ZW10 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF MAN2A1 KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 PLIN3 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 IGF2R ACTR1A ARF1 GOLGA4 VAMP3 DCTN2 CAPZA1 DCTN3 GOSR2 RACGAP1 YKT6 ARFGAP1 USP6NL HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 HS6ST1 HS6ST2 HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function JUP PRDM8 CTNND1 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism CSPG4 GUSB ARSB CHST3 CHST14 DSEL DSE UST CHST15 IDUA CHPF NCAN HEXB CHSY1 HEXA CHST11 CHST12 BGN GLB1L3 CHSY3 CHST13 DCN GLB1L2 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b MPI NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors LPAR4 ADORA2B GPR17 P2RY10 P2RY11 LPAR6 ADORA2A P2RY12 P2RY6 P2RY13 P2RY2 P2RY14 P2RY1 P2RY4 ADORA3 ADORA1 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy MAP1LC3A FUNDC1 VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 ULK1 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN CSNK2A1 TOMM40 CSNK2A2 UBE2D2 UBE2D3 CSNK2B MTERF3 PINK1 UBE2N NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes CREBBP GEM ARNT NAMPT CDK5 RBFOX3 INS PLK2 NPAS4 MDM2 IQSEC3 MAPK1 ARNT2 BDNF XPO1 FOS BMAL1 CDK5R1 MAPK3 RET SYT10 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling JAK3 STAT5A STAT5B STAT3 IL9 JAK1 STAT1 IL2RG IL9R SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNA13 GNGT2 GNAT3 PLA2G4A GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 TBXA2R GNG7 AAMP MAPK14 GNA11 GNG8 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 P2RY1 GNG12 GNG11 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 GPRIN1 GRIA2 HDAC1 HDAC2 OPRK1 GRIN2B SIN3A SLC2A3 MET GRIN2A TRPC3 OPRM1 PTPN1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin PIK3CB RAPGEF1 SOS1 STAT5A STAT5B SHC1 PIK3CD LYN PIK3R1 PIK3CG PIK3R5 NRAS PLCG1 HRAS JAK2 GAB1 PLCG2 CRKL PIK3CA EPO VAV1 EPOR IRS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis UBC ENO1 TRIM27 RPS27A RAB7A KPNA1 SFPQ UBA52 ATP6V1H MAPK1 NOS2 CTSG VPS33B DUSP16 CORO1A PGK1 HGS RNF213 RAB5A GSK3A KPNB1 MAPK3 UBB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ACADL HADHA ACADM DECR1 ECI1 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNG13 ARHGEF9 GNB2 GNB1 ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 GNAT3 GABRG3 GABRG2 GABRB3 GABRB2 GABRB1 GNG3 GNG2 GABRR3 GNG5 GABRR2 GNG4 GABRR1 GNG7 NPTN GNG8 GNAI3 GNAI1 GNAI2 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u DPM3 DPM1 DPM2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IQGAP1 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 ADCY8 GNGT1 KCNC2 ADCY6 GCG ADCY5 GNGT2 RAP1A PRKACG PRKACA PRKACB GLP1R RAPGEF3 RAPGEF4 KCNB1 GNG3 ITPR1 KCNS3 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A KCNG2 AKAP5 GNG10 GNG12 GNG11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRA2C ADRA2B ADRB1 ADRA2A ADRA1D ADRB2 ADRB3 ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CREBBP MAFK NFE2L2 EP300 CCL2 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME UGT2B7 ABCB1 UGT1A3 AKR1C1 CYP3A4 HSD11B1 HSD11B2 ALB UGT2B17 SERPINA6 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC TAB3 RPS27A TICAM1 TLR3 TAB2 MAP3K7 TRAF6 UBA52 UBB TAB1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex NEDD4L ITGB8 ITGB5 SERPINE1 PMEPA1 FURIN PARP1 BAMBI STRAP HDAC1 RHOA TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 MAPK1 ITGA8 SKIL PPP1R15A MAPK3 TGFB2 ATP1B4 TGFB3 SKI CDK8 NCOR2 SMAD2 MTMR4 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC SMURF1 TGFBR3 E2F4 FKBP1A CCNT2 PPM1A E2F5 UBE2D3 XPO1 RBL1 TGIF1 STUB1 UBE2D1 TGIF2 TRIM33 CCNK CBL CCNC UBA52 CDKN2B COL1A2 PPP1CA USP15 CCNT1 TFDP1 TFDP2 PPP1CB PPP1CC UBB UBC SP1 UCHL5 RPS27A CDK9 EP300 JUNB PARD6A NEDD8 CGN F11R RNF111 MEN1 PRKCZ WWTR1 PARD3 USP9X LTBP4 ITGB3 ARHGEF18 ITGB1 LTBP3 ITGAV LTBP1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 C4A C3 CFB C4B_2 C2 C5 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 LTC4S PON3 ALOX5AP PON2 PON1 GPX2 GPX1 ALOX5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins FZD2 FZD5 FZD7 WNT5A FZD4 PRICKLE1 FZD1 FZD8 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 SCRIB VANGL2 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PARD6A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 DVL2 PSMC1 PSMC2 FZD3 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance CLTB ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 TYROBP DOCK1 ERBB2 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM ANK1 SEM1 FYN CLTC CLTA AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 MSI1 COL6A2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 ROCK1 ROCK2 CNTN1 DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 YES1 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PDGFB CTSG PRSS2 KLK2 A2M PECAM1 P4HB TIMP1 BMP2 PLG LAMA5 LAMA2 PPIB LAMB3 LAMC3 LAMB2 LAMA1 P4HA1 LAMA4 ELANE P4HA2 LAMA3 FN1 P4HA3 LAMB1 LAMC2 LAMC1 VTN CAPNS1 CAPNS2 CAPN2 CAPN1 BMP7 CAST DAG1 MMP1 MMP2 MMP3 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 FBLN1 LTBP3 FBLN2 LTBP1 FBLN5 LOXL1 LOXL2 COL17A1 EFEMP2 COL15A1 COL16A1 EFEMP1 COL13A1 ITGB8 GDF5 COL14A1 COL11A1 PLEC MFAP5 COL11A2 BMP4 COL12A1 MFAP4 COL19A1 LOX COL10A1 MFAP3 COL28A1 MFAP2 FBN1 COL26A1 COL27A1 COL24A1 COL25A1 ACTN1 NCSTN COL22A1 COL23A1 COL2A1 ADAM10 COL5A1 PSEN1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 SDC4 COL5A2 COL8A2 SDC2 COL20A1 SDC3 COL4A6 COL6A3 COL21A1 COL8A1 COL4A5 COL6A6 COL6A5 NTN4 CDH1 CTSS SDC1 PRKCA KLKB1 COL1A1 COL1A2 ITGA10 PRSS1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 PHYKPL CTRB2 CTRB1 P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 DTNA DTNB SSPN CTSB DDR1 MMP20 MMP24 TPSAB1 MMP13 MMP10 MMP12 MMP11 MMP14 MMP16 CASP3 MMP15 COL18A1 MMP17 MMP19 ITGA3 DDR2 ITGB4 TMPRSS6 ITGA1 DRP2 NID1 DMD NID2 JAM2 ITGA6 FURIN JAM3 PLOD3 PLOD2 PLOD1 SPP1 CAPN8 CAPN9 CAPN6 TGFB1 CAPN7 CAPN5 CAPN3 PCOLCE ADAM15 ADAM12 ADAM9 UTRN CD151 HTRA1 SCUBE3 SNTG2 SCUBE1 CRTAP VCAM1 TRAPPC4 BMP1 ITGA11 COLGALT2 MMP25 ITGAE TIMP2 SGCE SGCD SGCA SGCB ITGB7 COLGALT1 SGCG ADAM17 SNTA1 ITGAD PCOLCE2 SPOCK3 SGCZ CAPN13 NCAN CAPN14 CAPN11 CAPN12 BGN CAPN10 TLL2 DCN TLL1 SNTB1 BCAN CASK SNTB2 VCAN CMA1 ADAM8 ITGAM SH3PXD2A ITGB2 FGF2 TTR F11R CTSD ITGB3 ITGA2B ITGB1 COL3A1 ITGAV COL4A2 NCAM1 COL4A1 ITGA5 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 ITGAL TNXB LRP4 ACAN TGFB2 CEACAM6 LUM CEACAM8 TGFB3 CD47 DSPP COL9A1 CD44 ITGA4 COL9A3 COL9A2 AGRN FMOD ADAMTS4 ADAMTS5 NRXN1 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 KDR ADAMTS9 THBS1 ADAMTS16 ADAMTS14 ADAM19 FGB ADAMTS18 FGA MMP8 FGG MMP9 PDGFA CEACAM1 PXDN BSG CTSV CTSL MMP7 CTSK TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling XIAP TRAF2 FADD USP4 BIRC2 USP2 BIRC3 MIB2 CYLD RBCK1 OTUD7B RIPK1 USP21 SHARPIN TNF TBK1 OPTN TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 NEK2 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 COPS5 PSMD3 PSMD1 GSK3B CUL1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT2 GPAM PLA2G4A PLA2G2A RAB5A PIP4K2A PIP4K2B LIPI PIP4K2C LIPH BMX STARD7 RUFY1 PLBD1 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 PTPMT1 PIP5K1A PIP5K1B CHKB CHKA STARD10 ARF3 ACHE MTMR14 LPCAT1 OSBPL10 GNPAT PIP4P1 GPAT4 GPAT3 CEPT1 BCHE AGK LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 LCLAT1 PIP5K1C PCYT2 PGP PLA2R1 INPP5D ABHD4 PIK3CG PIK3R6 ABHD3 PIK3R5 ARF1 OSBPL8 RAB4A OSBPL5 OCRL SYNJ2 SYNJ1 PIK3CD PIK3C2G PIK3C2B ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B TPTE AWAT2 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 RAB14 LPGAT1 PITPNB CPNE7 CPNE6 GDE1 CPNE1 CPNE3 MFSD2A SACM1L PISD PLA1A PGS1 PTDSS2 PTDSS1 INPP5J INPP5K TMEM86B PTEN MTMR1 PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 GDPD1 GDPD3 GDPD5 PIK3CB PNPLA7 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 ETNPPL PLEKHA8 PNPLA3 PNPLA6 PTPN13 INPPL1 PLB1 ENPP6 PIK3R3 SBF1 PIK3CA SBF2 TPTE2 PIK3C3 MIGA2 MIGA1 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 INPP5E CHAT PLD4 PLD6 PLD3 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 PI4KA VAC14 PI4K2B PLD2 MTMR10 ALPI MTMR2 GPD2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A PCTP LPIN1 FIG4 LPIN2 INPP4B MGLL PLA2G4F PIKFYVE LPIN3 INPP5F PI4K2A PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 AGPAT5 PLA2G1B AGPAT1 SELENOI AGPAT3 AGPAT4 PLA2G2F PLA2G2D PLA2G2E CHPT1 GPD1L CDS1 PITPNM1 PITPNM3 PNPLA2 PITPNM2 CDIPT SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC MRE11 NLRC3 IFI16 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions ITGA10 CHL1 ITGA2 ITGA1 ANK1 CNTN6 HSPA8 NRP1 ITGB1 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKAR2A PRKACG PPP3CB AKAP5 PRKACA PRKACB OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF QRFPR HCRTR1 QRFP NPFFR2 HCRT NPFFR1 HCRTR2 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis RXRA NR1H2 NR1H3 RXRB NCOR2 NCOR1 UGT1A3 FABP6 NCOA1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks RAD50 MRE11 KPNA2 ATM KAT5 NBN MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR5AL1 OR8H3 OR8H2 OR8H1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 KCNMA1 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 SLC17A8 OR2A25 OR51I2 ITPR3 TAS2R30 TAS2R31 LRP8 OR10S1 TAS2R38 KCNMB1 OR52K2 OR51I1 TAS2R39 OR52K1 CNGA2 APOB RPE65 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 ATP2B1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 TAS2R50 OR4D1 OR5F1 OR10Z1 NMT1 OR52R1 OR4C6 OR4C5 OR3A3 SPTAN1 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 HSD17B6 OR4C45 OR5AN1 OR4B1 OR4C46 GSN OR8J3 OR6F1 OR8J2 FNTA OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 PRKCQ OR5H14 OR2D3 OR52A4P CYP4V2 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 CALHM1 OR6K2 CALHM3 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 CAPZA2 OR5H6 OR4F5 OR2B3 SDC4 OR4F4 OR2B2 SDC2 OR10K2 SDC3 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 GPC1 OR51A7 OR2A2 GPC3 TAS2R7 GPC2 OR52J3 GPC5 RTP2 GPC4 OR51H1 TAS2R8 GPC6 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 SDC1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 OR51G2 OR51G1 OR52I2 SNAP25 OR52I1 RAB3A OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 DNAJC5 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 MSN OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 CAPZA1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LRP2 AWAT2 GNG13 GNB1 GNB3 GNGT1 RDH5 RLBP1 HSD17B1 CAPZB AKR1C1 TTR AKR1C4 PLB1 SPTBN1 CALM1 RDH11 RDH10 RDH16 AKR1C3 DHRS3 DHRS9 APOA2 APOA1 APOA4 LPL LDLR GPIHBP1 APOC3 TRPM5 TRPM4 MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 GRM1 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B PLCB2 MYO3A FSCN2 EZR TWF2 PCDH15 PDE6B CABP2 PDE6A USH1C CACNA1D CABP1 LRRC52 ESPNL PDE6G EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 LHX2 STX1A SCN1B OTOF SCN3A SCN2A SCN2B PRKCA KCNQ4 SCN9A SCN4B VAMP2 ABCA4 SCNN1G SCNN1D SCNN1B SCNN1A RBP4 RDH12 OPN1LW RBP1 LRAT STRA6 OPN1MW CASK OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 GUCY2D OR2AE1 GUCA1B OR11H6 GUCA1A OR11H7 GUCA1C OR2L8 GUCY2F OR1J4 GRK1 OR2L5 GRK7 OR11G2 FNTB OR1J2 RHO OR2L3 CNGA1 GNAT1 OR4P4 OR1J1 RCVRN OR2L2 CAMKMT OR10AD1 RGS9BP OR6T1 SAG OR4K15 NMT2 RBP3 PPEF1 OR4K14 METAP1 OR4K13 METAP2 OR13J1 CNGB1 OR7A2P CHRNA9 OR2K2 CHRNA10 OR1I1 KCNN2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 GNAT3 OR1L1 OR5T3 HSPG2 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOE OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P EPB41L1 OR5AS1 OR2T8 OR2T7 OR2T6 AGRN OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 APOC2 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 KCNJ2 OPN1SW OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 LRP1 RETSAT OR6C74 OR14I1 APOM OR10A7 OR56A5 BCO2 OR7A5 BCO1 OR10A2 OR56A4 AKR1B10 CLPS OR10A4 RBP2 OR56A3 SLC24A1 OR10A3 LRP10 OR10A6 LRP12 OR56A1 PNLIP OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL SRC YWHAB HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex XIAP SOX17 APC SRY YWHAZ SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 TCF7L2 PYGO1 BCL9 TCF7L1 PYGO2 HDAC1 UBA52 LEF1 TCF7 TLE4 TLE2 TLE1 BTRC RBBP5 CTNNB1 CTBP1 UBB UBC ASH2L RPS27A KMT2B SOX2 AKT2 MEN1 SOX9 TLE3 XPO1 DPY30 WDR5 AKT1 CHD8 CBY1 SOX3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CDK1 CCNB2 CLIP1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN JMJD6 RIOX2 BGLAP EIF5A DHPS FN3KRP EIF5A2 FN3K ICMT DOHH RPL8 STS RWDD1 JMJD4 KDM8 JMJD7 ARSA ETF1 RIOX1 OGFOD1 SUMF2 SUMF1 DRG1 DRG2 RCCD1 ZC3H15 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD F8 RPL27A ARSB ASPH U2AF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 RPS6 DPH6 DPH7 EEF2 F7 F9 PROC F10 TPST2 GGCX PROS1 TPST1 PROZ F2 GAS6 RPS23 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 CD209 BTN3A2 BTNL2 PPL XDH INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals MT1G MT1H MT1X MT4 MT1B MT3 MT1E MT2A MT1A MT1M MT1F GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib SLC37A4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib ERBIN HSP90AA1 ERBB2 CDC37 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 RASGRP2 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A RARRES2 IGF2 RAF1 RAB27B IGF1 PPBP RAPGEF3 CYRIB MANF RAPGEF4 SELP TF SCCPDH CALU MAGED2 PLA2G4A HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 ITPR1 CTSW ITPR2 ORM2 ITPR3 SERPINA4 TMSB4X PSAP ALB PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 TRPC7 ABCC4 AHSG ANXA5 F5 TRPC6 PLCG2 F8 TRPC3 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 CRK LEFTY2 LY6G6F LHFPL2 PCYOX1L CD9 FLNA FN1 F2RL2 F2RL3 LCP2 F2R LAT PRKCB RAC1 VAV3 PRKCQ P2RY12 P2RY1 VAV1 VAV2 MPL THPO ACTN1 GNA13 ADRA2C ADRA2B ADRA2A TBXA2R AKT1 GP1BB PRKCD PRKCA GP5 YWHAZ GP9 LYN PIK3CG PIK3R6 PIK3R5 GP6 CFL1 PF4 SOD1 AAMP MAPK14 PPIA TUBA4A PRKCG PRKCE GNG10 GNG12 GNG11 GNG13 GNB2 CFD GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TGFB1 GNGT2 GNA14 GNG3 GNA15 PDPN MPIG6B GNG2 CLEC1B GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 EGF PIK3CB PFN1 PRKCZ BCAR1 PCDH7 PDPK1 PIK3R3 PIK3CA ITGB3 ITGA2B SOS1 BRPF3 SPARC RAC2 SHC1 SERPINE1 RHOG PIK3R2 PIK3R1 GP1BA RHOA RHOB MAPK1 GNAT3 FCER1G MAPK3 PTPN1 TGFB2 PTPN11 TGFB3 CDC42 MGLL DGKG SRC ACTN2 DGKE DAGLA DGKD DGKB DGKA ABHD6 GNAI3 ABHD12 PRKCH GNAI1 DGKZ DGKQ GNAI2 DAGLB DGKK DGKI DGKH CALM1 CD36 VEGFB VEGFC VEGFD THBS1 VEGFA ALDOA GNA12 CSK FGB FGA VWF FGG APBB1IP TLN1 VCL PTPN6 SYK LCK FYN APP F13A1 POTEKP ISLR LAMP2 HABP4 PROS1 FAM3C CHID1 F2 PTK2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 TREX1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction KCNJ11 ABCC9 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 GUCY1A2 GUCY1A1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MME ATP2B4 NPR1 ATP2B3 NPR2 ATP2B2 NPPC ATP2B1 CORIN TRPC1 CES1 SLC8A3 TTN ANXA1 PXN KCNK6 KCNK7 KCNK1 MYL12B CACNA2D2 MYL6 MYH11 CACNB2 NKX2-5 SCN11A SCN10A TMOD3 SCN1B SCN1A MYL9 KCNH2 SCN3B SCN3A KCNK10 GATA4 KCNK13 SCN2A KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 SCN9A KCNK9 SCN8A CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A ANXA2 KCNA5 SCN4A SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 TRIM72 PAK1 DYSF LMOD1 AHCYL1 MYL6B CACNA1H MYL12A MYLK CACNA1G CACNA1I ALDH2 PAK2 CALD1 ANXA6 MYL10 CAV3 TPM2 MYL11 TPM1 SORBS1 SORBS3 MYL5 MYL7 ITGA1 DMD SLN ATP1B3 ATP1B2 ATP1B1 PDE5A VIM ACTN3 KCNK12 KCNK15 FXYD4 MYL4 FXYD3 MYL1 MYL2 FXYD2 MYL3 DMPK FXYD1 MYBPC3 FXYD7 MYBPC1 FXYD6 MYBPC2 TNNC1 RYR1 TNNC2 RYR2 TNNT1 RYR3 TNNT2 TNNT3 TCAP CLIC2 TMOD1 TMOD4 TMOD2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 MYH3 MYH8 MYH6 ATP1A4 CACNG6 ATP1A3 CACNG7 TNNI1 ATP1A2 TNNI2 TNNI3 ATP1A1 KCNIP1 TPM4 KCNIP2 KCNIP4 TPM3 DES RANGRF PLN KCNIP3 FKBP1B ITGB5 CACNB1 CAMK2B CAMK2D ACTN2 CAMK2A TBX5 CACNG8 CALM1 CAMK2G CACNG4 KCNJ2 KCNJ4 KCNJ12 TLN1 VCL WWTR1 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A TCEA1 ERCC8 DDB1 XPA COPS7B COPS7A CUL4A COPS3 PPIE COPS6 COPS5 COPS8 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication ORC4 ORC6 H2BC9 ORC1 H2AZ2 ORC3 H4C9 ORC2 H2BC8 H2BC5 H2BC3 KPNA1 H2BC1 H2AC20 KPNB1 H2AX H2AB1 H2AC19 KPNA6 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ORC5 H3C15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT SOX17 XIAP SRY RNF146 SOX6 WNT5A SOX7 SOX4 WNT1 BCL9L RUVBL1 CTNNBIP1 FZD1 SOX13 RYK USP8 PYGO1 FZD8 BCL9 PYGO2 TLE4 TLE2 TLE1 CUL3 TNKS SMURF2 USP34 DPY30 WDR5 AXIN2 BTRC RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 KLHL12 LGR6 WNT3 LGR5 CCDC88C RSPO4 DACT1 LGR4 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 EP300 SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 PPP2R5E H3C15 FRAT2 FZD2 FZD5 H2BC9 FZD4 H2AZ2 H4C9 FZD6 PPP2R5B H2BC8 PPP2R5A H2BC5 PPP2R5D H2BC3 PPP2R5C H3-4 TCF7L2 H2BC1 TCF7L1 HDAC1 H2AC20 LEF1 TCF7 PIP5K1B CTNNB1 PPP2CA PPP2CB ASH2L MYC RSPO3 TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 APC YWHAZ PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 CSNK1G2 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 LEO1 WNT3A LRP5 PSMA7 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 KAT5 LRP6 PSMB4 DKK4 SFRP1 CTBP1 PSMB5 CSNK1E SFRP2 UBB WIF1 SOST PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A TERT ADRM1 MEN1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 WNT4 SMARCA4 PSMC1 CSNK2B PSMC2 TLE3 CHD8 CAV1 CBY1 SOX3 TRANSLATION%REACTOME%R-HSA-72766.7 Translation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 APEH HEMK2 MRPS18B MRPS18A ETF1 GSPT2 MRPS21 GSPT1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 TUFM MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 RARS1 EIF2B5 MRPL30 EIF2B4 EIF2B3 MTRES1 LARS1 EIF2B2 MTRFR NDUFAB1 EIF2B1 AIMP1 AIMP2 RPS4Y2 QARS1 RPS27L RPS4Y1 RPS4X MARS1 RPS15 RPS14 DARS1 RPS17 SARS1 EEF1E1 RPS15A RPS16 RPS19 KARS1 RPS18 RPS3 IARS1 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPN2 ASCC2 RPN1 ASCC3 EIF2S2 EIF2S1 DDOST MT-CO1 EIF2S3 EPRS1 EIF4EBP1 EIF4E EIF4B TRMT112 EIF1AX UBE2D2 EIF4H PSMD8 UBE2D3 EIF3M PSMD6 EIF3K MT-CO2 EIF3L PSMD7 MT-CO3 ELOB EIF3I ELOC EIF3J PSMD2 RBX1 EIF3G EIF3H PSMD3 EIF3E CUL2 EIF3F PSMD1 EIF3C EIF3D EIF3A EIF3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 LTN1 NPLOC4 PSMD12 SEC61G PSMD11 RPLP0 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SSR1 PSMC2 EIF4G1 SRPRA SRPRB MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 SEC61A2 SPCS3 SEC61A1 SPCS2 VCP SPCS1 SEC11A SEC11C MT-ATP6 MT-ATP8 MT-ND4L PARS2 EARS2 LARS2 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 EIF4A2 TCF25 SRP54 EIF4A1 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 MT-CYB SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 CARS2 VARS2 ANKZF1 KLHDC10 TSFM RPL4 EIF5B RPL5 MARS2 RPL30 DARS2 RPL3 EEF1G RPL32 SARS2 RPL31 NEMF RPLP1 EEF1D RPL34 MTRF1L RPL10L EEF1A1P5 RPL8 MTIF2 RPL10A MTIF3 RPL6 IARS2 RPL7 WARS1 RPL7A WARS2 RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 SRP14 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBE2D1 SEM1 EEF2 MRPS17 MRPS15 MRPS16 MRPS14 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2B GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 GRIA3 CAMK2G GRIA4 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO2 SLIT1 NCK2 ROBO1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism PLCB4 MTMR9 INPP5D MTMR7 PLCG1 PLD4 IPPK ISYNA1 IPMK OCRL INPP1 IP6K1 NUDT3 IP6K2 NUDT4 INPP5B SYNJ1 NUDT11 NUDT10 INPP5A IMPA1 PPIP5K1 PLCZ1 IMPA2 INPP4A PPIP5K2 INPP5J PLCE1 INPP4B IP6K3 MIOX ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers JUN SEL1L FZD8 ERLIN2 NPM1 KLC1 MAMLD1 IHH DERL2 TRAK1 ERLEC1 OS9 KIF5B PRR5 GSK3A EML4 KRAS MAML2 MAML1 FGFR2 JUNB RAC1 MAML3 VAV1 MAPKAP1 DUSP6 DUSP7 GZMB DCTN1 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 MAPK8 BCL2L11 PAPSS1 BAD CD19 SQSTM1 AGK RBX1 POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F PIK3CG POLR2G POLR2H PIK3R6 POLR2I PIK3R5 POLR2J POLR2K POLR2L WDR48 GTF2F1 GTF2F2 IL10 PTPN12 MSN TYK2 KAT2B PIK3CD KAT2A ALK LMNA TP53 VCP TNKS FOXO4 FOXM1 CDK8 SMAD2 SMAD4 SMAD3 ESR1 JAG2 ADAM17 MDM2 ZMYM2 PTEN ARRB1 ARRB2 TPR HDAC5 RANBP2 FGFR3 HDAC8 HDAC9 HDAC6 HDAC7 TPM4 RNF43 TPM3 KLB FLT3 IRS1 PPP1CC PPP2R1B IRS2 PPP2R1A PIK3CB TNKS2 PPM1B FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 HDAC10 FGF9 HDAC11 AKT2 HRAS PDPK1 GAB1 FLT3LG TWIST1 FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 CARS1 PIK3R1 NRAS FGF20 PPFIBP1 MAPK1 EEF1G FGF23 CHUK FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 SNW1 CAMK2B ESR2 CAMK2D SRC NR4A1 CAMK2A NRG1 TFG MPRIP FGFR1OP2 ZAP70 SND1 ZC3HAV1 EIF2AK3 NOX4 CALM1 ATIC CAMK2G DUSP8 DUSP9 MRAS FAM114A2 KDR PORCN MCL1 CD86 QKI CD80 NF1 KIAA1549 ERBB2 DUSP10 CCNB1 HES1 ESRP1 TRAT1 BIRC6 RPS6KB2 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 PHB1 AGTRAP ARAF AP3B1 SHOC2 PEBP1 CSK AGGF1 JAK2 CPSF6 MARK3 TENT4A SPRED3 FGB BRAP SPRED2 SPRED1 FGA VWF MYO18A KSR1 LRRFIP1 KANK1 PPP1CB FGG RRBP1 BRAF ETV6 WDCP KSR2 GOLGA4 FAM131B BIN2 CNKSR2 STRN APBB1IP CNKSR1 NCBP1 TLN1 NCBP2 VCL FRS3 JAG1 LCK SEM1 IRF4 DLL1 FYN BCL2A1 SKP1 HGF CLIP1 CUL1 CLTC GCC2 NTRK3 NTF3 PDGFB NEURL1B HES5 MIB2 RAP1B MIB1 HEYL RAP1A NEURL1 RAF1 PRF1 ICOS STAT5A IL10RA ZC3HC1 FIP1L1 FN1 CUX1 TRIP11 RPS6 PDGFRA PRKAR1A MYH9 KIT NOTCH1 FZD5 FZD4 HBEGF FZD6 TCF7L2 CDKN1A HDAC1 CTNNB1 MET CEBPB RNF213 ATG7 SEC31A RBPJ TNRC6C MOV10 MLST8 AGO3 AGO4 MYC AGO1 AGO2 TSC2 PIM1 MTOR YWHAB FKBP1A PSMD8 PSMD6 PSMD7 PSMD2 AKT1S1 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 PSMB5 UBB BCR PSMB2 PSMB3 LMO7 UBC PSMB1 RPS27A AKAP9 HEY1 HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CASP9 ERBIN CEP43 KDM7A TGFB1 RICTOR TGFBR1 TGFBR2 STAT1 CD28 IQGAP1 HSP90AA1 EGF CBL EGFR CDC37 PLCG1 RB1 CDKN1B MAP3K11 DUSP16 FGFR1 CLCN6 FOXO6 FOXO1 EP300 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 ITGA2B NRG2 STAT3 HDAC3 TBL1X NCOR2 NCOR1 TBL1XR1 HDAC4 HDAC2 PIK3AP1 AMER1 GSK3B CSNK1A1 AXIN1 APC STAT5B CCNC GRB2 HHAT SHH DHH CTBP2 CTBP1 DNMT1 CREBBP AREG BCL2L1 PTPN6 MAPK9 YES1 NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 EREG SYVN1 BTC EPGN AKT3 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP PPHLN1 H2AC20 MPHOSPH8 H2AX ZCCHC8 EHMT2 EHMT1 H2AB1 TASOR MTREX H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B RBM7 H3C8 MORC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SETDB1 H3C15 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK10 MAPK8 FOS MAPK3 MAPK9 MAPK14 ATF2 MAPK11 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 ALOX5 LTA4H DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 NEIL1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 C2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress GNG13 ITGA5 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 PIK3R2 GNB3 ADCY4 NFKB1 ADCY3 GNB5 ADCY2 ADCY1 ABL1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB CHUK STAT1 PTPN1 IKBKB PPP2CA PECAM1 MLST8 GNG3 GNG2 GNG5 NFKBIA GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 IKBKE AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 IKBKG PPP2R1B ANXA2 PPP2R1A PIK3CB CALCRL ADM TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PTK2 PIK3CA P2RY2 ITGB3 ITGB1 MMP14 GNG12 ITGAV MAPKAP1 GNG11 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor F8 VWF MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2A POLR2B BCDIN3D POLR2C XPO5 POLR2D AGO3 PRKRA POLR2E DROSHA RAN DICER1 AGO4 POLR2F TARBP2 POLR2G POLR2H AGO1 POLR2I AGO2 POLR2J POLR2K POLR2L DGCR8 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly HSP90AA1 IPO5 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis RXRA CYCS SAMM50 HDAC3 MTX1 APOOL NR1D1 CHCHD3 DMAC2L TBL1X NCOA1 ESRRA PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 MT-ATP6 PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 MAPK12 HCFC1 CALM1 ATP5PF ATP5PD PPARGC1A ATP5PB NCOA2 PPARGC1B ATP5F1C NCOA6 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 NRF1 ATP5PO GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HSPA9 HELZ2 ATP5MC2 CREBBP CHD9 ATP5MC3 ALAS1 ATP5MK ATP5MJ MICOS13 MICOS10 CHCHD6 MTERF1 ATP5MG MAPK14 GABPA MED1 MAPK11 SIRT5 TGS1 ATP5MF PPRC1 MEF2D ATP5ME PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 ATP5F1A IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 MTX2 PPARA ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion PRKCA CHRM3 GNA14 GNAQ MARCKS GNA15 PLCB3 PLCB1 PLCB2 GNA11 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors MEF2C RBFOX1 PPARG RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 H2BC15 TP53 H2BC11 ATM UBE2N MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase SHQ1 ACD DKC1 TINF2 TERF1 RUVBL2 TERF2 RUVBL1 TERT NHP2 ANKRD28 POT1 NOP10 TERF2IP WRAP53 PPP6C PPP6R3 RTEL1 CDK2 CCNA2 CCNA1 PIF1 GAR1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RIPK1 CASP10 MAVS FADD RNF135 RIGI CHUK IFIH1 CASP8 TRIM25 TRIM4 IKBKG CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions CDH24 CTNNB1 CDH11 JUP CTNND1 CDH8 CTNNA1 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 FCN1 MASP1 FCN2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway TALDO1 PGD DERA TKT RPIA PRPS2 PRPS1 RPEL1 RPE SHPK PGLS PRPS1L1 RBKS G6PD PGM2 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 FLRT1 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 GIPC1 ANOS1 MAPK1 FLRT3 FGF23 FGF22 SPRED2 SPRED1 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FRS3 FGF3 RPS27A FGF4 FGF6 FGF9 TGFBR3 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 SEL1L PSMA3 CFTR PSMA4 PSMA1 PSMA2 ERLIN1 ERLIN2 UBA52 PSMD12 PSMD11 RNF185 PSMD14 PSMD13 PSMA7 PSMB6 VCP PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 DERL3 DERL1 UBC DERL2 PSMB1 RNF5 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein PRMT1 UBE2I SRPK1 SUMO1 PARP10 SRPK2 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 CSNK1A1 PARP14 PARP8 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB RIPK1 UBC TICAM2 UBE2D1 TICAM1 RPS27A UBE2V1 LY96 TRAF6 UBA52 BIRC2 CD14 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB TLR4 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON GRK2 IHH ARRB1 SHH DHH ARRB2 SMO KIF3A CSNK1A1 PTCH1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress COX5B COX5A RELA NUDT2 PRDX3 NOX5 NQO1 GSTA3 COX6C GSTA1 ERO1A SESN1 SRXN1 CHD6 GPX3 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB COX6A1 BLVRA CCL2 ABCF2 COX6A2 TXNRD2 SOD3 CCS G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM ALB P4HB AQP8 CAT BTRC SOD2 CARM1 ATOX1 FBXL17 BACH1 PRKCI SLC7A11 MED1 NOTCH1 PRDX2 PRDX1 PTK6 CDKN1A CDKN2A SIN3A PRKAA2 MT-CO1 SQSTM1 ATF4 TKT MYC PSMD8 KEAP1 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 PSMD2 RBX1 PSMD3 AKT1 PSMD1 IDH1 PRKCD NCF1 PSMA5 NCF2 PSMA6 NCF4 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 NPLOC4 PSMD12 PSMD11 UBXN7 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CYBB PSMB4 CYBA DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 TALDO1 UBC PSMB1 RPS27A SOD1 ADRM1 CSNK2A1 PSMC5 GPX1 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PPARA CYCS MAFG PGD MUL1 CUL3 VCP PRDX6 NLRP3 TRIM21 GSTP1 HBA2 SESN2 HMOX2 GPX2 MAP1LC3B EGF SMARCD3 SKP2 TXNRD1 EP300 AKT2 STAP2 COX7A2L TXN RXRA STAT3 NFKB1 ABCG2 HBB HDAC3 COX4I1 COX4I2 TBL1X NCOA1 FABP1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 ABCC3 ABCC1 HM13 EIF2AK3 AMER1 NOX4 GSK3B NCOA2 NCOA6 ME1 TXN2 BRCA1 HELZ2 CREBBP SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 PALB2 TGS1 SEM1 COX7B SKP1 COX7C COX8A COX8C CUL1 AKT3 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 BCL11B SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 PHF10 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 BICRAL BRD7 BICRA BRD9 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 DPF1 HDAC2 DPF2 KAT8 DPF3 KDM5B SUZ12 KAT14 SETDB1 SS18L1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SS18 SMARCB1 BCL11A AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 KDM6A DNMT3A PBRM1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 AP2M1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA CSTF2T CLP1 ZNF473 SNRPD3 FIP1L1 SNRPB PABPN1 CPSF4 SLBP CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 CSTF2 CPSF2 CSTF1 PAPOLA SYMPK LSM10 NCBP1 LSM11 NCBP2 PCF11 SNRPG WDR33 SNRPE SNRPF TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR GCHFR GCH1 SPR NOS3 PTS HSP90AA1 PRKG2 AKT1 CALM1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion FES PLXNA2 PLXNA3 HSP90AA1 HSP90AB1 PAK1 PAK3 LIMK1 RAC1 FYN CFL1 PLXNA4 PAK2 NRP1 PLXNA1 SEMA3A CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAH YWHAZ WEE1 SFN CCNB1 CDC25C CDK1 YWHAB CHEK2 YWHAE CCNA2 CCNA1 YWHAQ CHEK1 YWHAG TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN TIMP1 NCSTN APH1B PSEN2 TIMP2 PSEN1 TGFBR3 APH1A MMP14 MMP16 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP5 GP9 VWF GP1BA GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 FABP6 MGLL PLIN1 PPP1CA ABHD5 FABP12 PRKACG PRKACA LIPE PRKACB FABP9 PPP1CB FABP1 PPP1CC CAV1 FABP2 FABP3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling IL21R JAK3 STAT5A STAT5B STAT4 STAT3 JAK1 STAT1 IL2RG IL21 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine CBS CTH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly PET100 COX5B COX5A COA5 CMC1 SCO1 COX6C TACO1 SMIM20 COX4I1 COX4I2 SURF1 COX6A1 COX6A2 COX16 TIMM21 COX15 MT-CO1 COX18 COX6B2 HIGD1A COX6B1 COXFA4 COX7A2 COX7A1 COX11 COX19 COX17 COX14 RAB5IF COQ10B COQ10A TMEM177 COA3 SCO2 COA1 COX7A2L MT-CO2 COX7B MT-CO3 COX7C HIGD2A PET117 COX8A COX20 COX8C TMEM223 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM RTEL1 MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PIK3R1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 CD19 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CD22 TRPC1 IGKV2D-40 PIK3AP1 IGHV3-11 IGHV3-13 IGLV7-43 CALM1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 BTK IGLC3 BLNK IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 PIK3CD IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PTPN6 SYK AHCYL1 FYN VAV1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB P4HA1 P4HA2 P4HA3 COL1A1 COL1A2 ADAMTS14 P3H2 P3H1 P3H3 SERPINH1 COL3A1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC9 H2AZ2 H4C9 H2BC8 NCOA2 H2BC5 H2BC3 H2BC1 H2AC20 PKN1 KDM1A H2AX KLK3 KLK2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B KDM4C H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 AR KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling CASP10 FAS CASP8 FASLG FADD SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins DNMT1 BMI1 RING1 UBE2I SUMO1 RNF2 DNMT3B CBX8 PHC2 PHC1 DNMT3A CBX4 PCGF2 CBX2 PHC3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FRS2 KLB PTPN11 FGF16 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus CLP1 POP5 POP7 POP1 RPP30 POP4 RTCB CPSF4 TSEN2 TSEN54 CPSF1 RPP38 CSTF2 RPP21 RPP25 DDX1 C2orf49 RPP40 TSEN15 ZBTB8OS TSEN34 NUP205 POM121 RPP14 NUP107 NUP188 RTRAF AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 XPOT NUP88 FAM98B NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ELAC2 TRNT1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) UBC DERL2 SEL1L RNF5 RPS27A OS9 MAN1B1 UBA52 RNF185 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 EDEM2 AMFR SYVN1 RNF103 UBB TRIM13 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1 OXCT2 ACAT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis GPI ENO1 ENO2 ENO3 ENO4 G6PC1 TPI1 PGAM1 PC PGAM2 ALDOC ALDOB ALDOA GAPDH PCK2 PGK1 SLC37A1 PGK2 G6PC2 PCK1 G6PC3 FBP1 FBP2 SLC37A4 GAPDHS CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SESN1 SESN2 SEC13 RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X RPS15 SAMTOR RPS14 SEH1L RPS17 NPRL2 NPRL3 RPS15A RPS16 GCN1 TCIRG1 RPS19 WDR59 RPS18 EIF2AK4 FLCN RPS3 MIOS RPS2 RPS11 ITFG2 IMPACT RPS10 DEPDC5 RPS13 KPTN RPS12 WDR24 RPS9 SH3BP4 RPS7 FNIP1 ATP6V1E1 RPS8 FNIP2 RPS5 KICS2 ATP6V1E2 RPS6 CASTOR1 RPSA CASTOR2 ATP6V1G1 RPS3A RPS26 ATP6V0B ATP6V0E1 ATP6V1G2 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ATP6V1B2 TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A RPL4 RPL5 ATP6V1H RPL30 RPL3 RPL32 ATP6V0E2 RPL31 ATP6V1G3 RPLP1 RPL34 ATP6V1D RPL10L RPL8 ATP6V1C1 RPL10A ATP6V1F CEBPB RPL6 ATP6V1C2 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPTOR RPL37 ATF3 ATF4 RPL39 RPL21 MLST8 RPL23 SLC38A9 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 MTOR RPL10 RPL12 RRAGA RPL11 RRAGC RPL36A RPL14 RHEB RPL13 RRAGB RPL15 RRAGD RPL18 RPL17 RPL19 LAMTOR2 RPL39L LAMTOR1 RPL41 LAMTOR4 RPL35A LAMTOR3 RPL23A LAMTOR5 RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism CHST2 B4GALT4 CHST3 B3GNT3 GNS ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 GALNS FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 HEXB HEXA B4GALT2 GLB1L3 B4GALT3 PRELP GLB1L2 CHST6 OMD KERA GLB1L B3GNT7 GLB1 B3GNT4 OGN CHST1 B3GNT2 CHST5 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway XIAP RACK1 TRAF1 TRAF2 MAP3K7 USP4 BIRC2 USP2 BIRC3 CYLD RBCK1 OTUD7B CHUK IKBKG IKBKB RIPK1 USP21 SHARPIN TNF OPTN TAB1 TRADD TAB3 TNFAIP3 TAB2 RNF31 SPATA2 TNFRSF1A OTUD1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 TGFB1 CCL11 CCL2 STAT1 VCAM1 VIM CCL22 BCL6 IL6 TIMP1 RORC RORA NOS2 POU2F1 IL17F IL17A ANXA1 LBP LAMA5 HSP90AA1 FN1 S1PR1 JAK3 IL18 IL1A ITGAM IL1B ITGB2 LCN2 MMP1 MMP2 FGF2 TNFRSF1B FOXO1 IL6R JUNB SOCS3 SOX2 MAOA MMP3 TWIST1 HSP90B1 ITGB1 IL23R IL13RA2 IGHG4 IL13RA1 IGHG1 IL4R STAT3 IL23A FSCN1 PIK3R1 CDKN1A NDN LIF RHOU NANOG ALOX15 IGHE ITGAX OPRD1 OSM BATF CCND1 BIRC5 FASLG SOCS1 FCER2 MYC PTGS2 PIM1 ALOX5 HMOX1 AKT1 HIF1A OPRM1 CD36 MCL1 GATA3 VEGFA POMC COL1A2 IL4 JAK2 MUC1 IL12B IL12A IL13 JAK1 IL2RG IL10 MMP9 SOCS5 BCL2 TYK2 TNF BCL2L1 HSPA8 ICAM1 ZEB1 CEBPD IRF4 STAT6 F13A1 SAA1 TP53 FOS FOXO3 HGF SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN NTRK1 RIT1 NGF RIT2 BRAF VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis NUP85 TPR NUP62 POLR2A POLR2B NUP88 POLR2C NUP43 POLR2D RAE1 POLR2E POLR2F NDC1 POLR2G RANBP2 POLR2H SEC13 POLR2I NUP155 POLR2J NUP133 POLR2K NUP210 POLR2L NUP153 NUP93 NUP50 NUP35 NUP54 GTF2F1 GTF2F2 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids GGPS1 CYP51A1 SRD5A3 LSS SREBF2 SQLE MTF1 DHCR7 SLCO1B1 SLCO1B3 LDLRAP1 CUBN ACACB GPAM STS SLC51A SLC51B CYP27A1 SAR1B CYP39A1 PLPP6 LHB ABCB11 SEC23A MBTPS1 SCAP VDR ALB SLC10A1 MBTPS2 SLC10A2 STAR AKR1B15 SEC24B SEC24A AKR1B1 ARV1 CYP17A1 SMARCD3 STARD3NL SEC24D CYP7B1 SEC24C AKR1D1 CARM1 KPNB1 HSD17B7 CYP7A1 HSD17B1 HSD17B2 HSD17B3 HSD17B12 AKR1C1 NSDHL AKR1C2 ACACA FDXR MED1 AKR1C4 STARD3 STARD4 CYP8B1 STARD5 STARD6 MSMO1 CH25H CYP46A1 FDX1 ELOVL6 FDX2 RXRA SCD FASN CGA SLC27A2 HSD11B1 HSD11B2 IDI2 NFYA EBP NFYB CYP11A1 NFYC TBL1X LGMN NCOA1 ACOT8 CYP11B2 SERPINA6 CYP27B1 TSPO CYP24A1 CYP2R1 CYP21A2 TBL1XR1 FABP6 SUMO2 ABCC3 UBE2I GC NR1H4 HSD3B7 OSBP HSD3B2 PIAS4 HSD3B1 AMACR NCOA2 SLC27A5 NCOA6 RAN INSIG2 INSIG1 CYP19A1 POMC ACAT2 MVD OSBPL9 LBR OSBPL7 OSBPL6 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 BAAT HELZ2 ACOX2 CREBBP CYP11B1 SLCO1A2 SP1 CHD9 OSBPL1A TGS1 AKR1C3 HSD17B4 HSD17B14 IDI1 LRP2 MVK TM7SF2 HSD17B11 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 PPARA TSPOAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer APC FZD5 FZD4 PORCN FZD6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 FZD8 WNT3A LRP5 RNF43 KREMEN1 CTNNB1 KREMEN2 DKK1 TNKS DKK2 LRP6 CTBP2 DKK4 CTBP1 PPP2R1B PPP2R1A TNKS2 PPP2CA PPP2CB AMER1 GSK3B CSNK1A1 PPP2R5E AXIN1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation CYB5B HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NMT2 AKT1 ZDHHC21 CALM1 CAV1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation HBEGF SH3KBP1 EGF ARHGEF7 CBL EGFR UBA52 STAM STAM2 HGS PTPRK EPS15L1 PTPN12 EPN1 UBB SPRY1 PTPN3 CDC42 UBC RPS27A SH3GL3 AREG EPS15 SH3GL2 SH3GL1 SPRY2 TGFA EREG BTC EPGN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis MT-ND6 MT-ND4 NDUFC2 MT-ND5 NDUFC1 MT-ND2 MT-ND3 NDUFS8 MT-ND1 NDUFS7 NDUFS6 PYURF NDUFS5 NDUFS4 NDUFS2 TMEM126A NDUFS1 TMEM126B NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFAF8 FOXRED1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFA9 NDUFA8 NDUFAF2 NDUFA7 SFXN4 NDUFA6 NDUFAF3 NDUFAF1 NDUFA3 NDUFA2 NDUFA1 TMEM186 ACAD9 OXA1L DMAC1 DMAC2 NDUFS3 TIMMDC1 NUBPL LYRM2 HSCB NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 ECSIT NDUFB10 HSPA9 NDUFB11 NDUFV3 NDUFV2 NDUFB8 NDUFV1 COA1 NDUFA5 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling SLC25A14 UCP1 SLC25A4 PM20D1 UCP3 SLC25A27 UCP2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer SKP1 RBX1 NOTCH1 CUL1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TIAM1 ERBIN ARHGAP26 MPP7 VANGL1 RAC2 ARHGAP32 ABI2 TAOK3 PIK3R2 PIK3R1 ABI1 ESYT1 SAMM50 MTX1 ABR MCF2 PLD2 CDC42 DOCK4 ANKLE2 DOCK3 ARHGDIA LAMTOR1 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 IQGAP1 TFRC NCF2 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 EMD LBR GIT1 TMPO SWAP70 ARMCX3 CYBB CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 DSG2 VAMP3 RAB7A CDC42EP4 EPHA2 GARRE1 TRIO ARHGAP17 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 VAV3 NHS SLITRK5 DEF6 VAPB NCKAP1L PAK2 WASF2 PIK3CA PIK3R3 PAK4 DIAPH3 ITGB1 VAV1 GIT2 VAV2 CAV1 MCAM TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 INS PLK2 NPAS4 MAPK1 ARNT2 REST BMAL1 SRF NR3C1 MAPK3 CDK5R1 RET KCNIP3 CREBBP GEM ARNT TNRC6C MOV10 NAMPT CDK5 AGO3 AGO4 RBFOX3 AGO1 AGO2 MDM2 TNRC6A TNRC6B IQSEC3 BDNF XPO1 FOS SYT10 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B GALNT12 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 SULT1C4 SULT2A1 SULT1A3 TPST2 TPST1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression JUN ZNF217 EBAG9 KDM4B YY1 DDX5 GPAM CXCL12 ESR1 POU2F1 TBP HSP90AA1 CARM1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 H3-3B H3C8 MED1 H2AC8 H2AC6 CTSD H2AC7 H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 HSP90AB1 KDM1A CCND1 PTGES3 NRIP1 FKBP4 NCOA1 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 KANK1 CREBBP SP1 BCL2 CDK9 KAT2B FOXA1 TLE3 KPNA2 TGFA USF1 FOS GREB1 CHD1 PGR TFF3 TFF1 CXXC5 USF2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation BANF1 XRCC6 XRCC4 XRCC5 LIG4 PSIP1 HMGA1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PARS2 YARS2 KARS1 EARS2 LARS2 PPA2 NARS2 RARS2 TARS2 AARS2 CARS2 VARS2 HARS2 MARS2 DARS2 SARS2 FARS2 IARS2 QARS1 WARS2 GARS1 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 MET STAT3 HGF VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 STAT5A STAT5B BCL2L1 CDKN1A PIK3R1 GRB2 NRAS PIM1 HRAS GAB2 PIK3CA FLT3 NOX4 PTPN11 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion ALPI MGAM PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B SI AMY1C CLPS LCT GUCA2B CEL GUCA2A CHIT1 LIPF PNLIP PIR PNLIPRP3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production KIF28P IFNA2 IFNA8 MAFG IFNA13 IFNA14 IFNA16 IFNA17 KIF5C ABL1 MFN1 KIF21A MFN2 KIF21B KIFAP3 KLC1 KLC4 IFNA10 KLC3 KLC2 PRKACG IFNA21 PRKACA IFNB1 PRKACB KIF16B KIF3A KIF20B WEE1 KIF3B KIF3C KIF5B CDK5 KIF5A KIF18B KIF4B KIF4A KIF12 PHF21A KIF11 DOCK11 KIF15 KIF19 KIF13B VPS45 KIF1C KIF1B KIF1A KIF25 KIF22 RCOR1 KIF6 KIF27 SH2B2 KIF9 KIFC2 KIFC1 HMG20B DOCK6 DOCK9 CABLES1 DOCK8 DOCK7 RAB5A CAPZB MYB KIF26A KIF26B GATA6 H3-3B H3C8 PRKAR1B PRKAR2B KIF23 PRKAR1A RAC1 PRKAR2A ZFPM1 RBSN KIF20A KIF18A GATA2 H3C15 IRF1 IRF2 NFE2 HDAC1 HBB KDM1A KIF2A SIN3A CDK2 KIF2C KIF2B CAPZA2 CDC42 ITPK1 DOCK5 HDAC2 CENPE DOCK4 DOCK3 CBX5 SH2B3 GATA4 JMJD1C HBE1 GATA1 DOCK2 ZFPM2 DOCK1 GATA5 AK3 MICAL1 CARMIL1 HBG2 GATA3 HBG1 EHD1 EHD2 EHD3 MAFF HBD DOCK10 AKAP10 AKAP1 SH2B1 CABLES2 JAK2 MAFK CAPZA1 RAD51B RACGAP1 RAD51C TP53 IFNA5 IFNA4 IFNA7 IFNA6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism MAN2C1 MANBA MAN2B1 MAN2B2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease FGF18 SOS1 FGF1 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGFR3 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA FGF16 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis GP5 GP9 SERPING1 KLKB1 GP1BA ADAMTS13 F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 MAPK1 FST FOXH1 ACVR1B FSTL3 ACVR2B ACVR2A INHBB DRAP1 INHBA ACVR1C INHA MAPK3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs YAP1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ABL1 H2AC20 ITCH LMO1 LMO2 PSMD8 PSMD6 TCF3 PSMD7 TCF12 LDB1 PSMD2 PSMD3 PSMD1 GATA1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 GATA3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CDK7 PSMB4 MNAT1 PSMB5 H2AX UBB PSMB2 SPI1 PSMB3 H2AB1 UBC H2AC19 PSMB1 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 MYB H3-3B ADRM1 H3C8 H2AC8 H2AC6 PSMC5 H2AC7 PSMC6 H2BC17 SEM1 PSMC3 RUNX1 PSMC4 H2BC12 PSMC1 H2BC13 PSMC2 H2BC14 TP73 H2AJ H2BC15 TAL1 H2BC11 KMT2A CBFB GATA2 H3C15 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1D HTR1A HTR7 HTR1B HTR5A HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NTRK1 SOS1 MAPKAPK3 SHC1 NGF MAPKAPK2 NRAS MAPK14 MAPK11 RALA SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A13 SLC25A18 SLC17A8 SLC6A1 SLC6A5 SLC22A2 SLC22A1 SLC6A4 SLC6A7 SLC6A19 SLC6A2 SLC6A15 SLC6A11 SLC6A3 SLC6A14 SLC6A9 SLC17A6 SLC6A20 SLC17A7 SLC25A22 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR CYP11A1 FDX1 FDX2 FDXR RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 BCL2L11 FOXO3 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation TLL2 TLL1 LAMB3 COL7A1 LAMA3 LAMC2 BMP1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L POLI UBB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC14A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 CDC20 ANAPC15 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF28P KDELR1 KDELR3 SURF4 KIF5C KIF21A KIF21B KIFAP3 KLC1 KIF2A KLC4 KLC3 KLC2 NSF KIF2C KIF2B RINT1 ARF3 KIF16B KDELR2 KIF3A KIF20B COPB2 COPA TMED10 SEC22B KIF3B TMED2 KIF3C KIF5B KIF5A KIF18B KIF4B KIF4A COPE KIF12 CENPE ARF4 KIF11 USE1 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 COPB1 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 ARF1 ARF5 NAPA GBF1 NAPB NBAS RAB1A STX18 RAB1B NAPG BNIP1 ARFGAP3 ARFGAP2 ARCN1 ZW10 KIF26A KIF26B COPG2 COPG1 KIF23 RACGAP1 KIF20A KIF18A ARFGAP1 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 RBBP4 DAXX NUP37 RBBP7 PML H2AC19 DYNC1LI1 H2BC26 H2AC14 DYNC1LI2 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 H2BC17 CHMP2B VPS4A CHMP2A H2BC12 MVB12B H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 ITGB1 H3C15 H2BC9 H4C9 CHMP3 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 HNRNPK SUZ12 H2AC17 H2AC12 NUP214 TRIM28 H2AC25 H2AC21 EZH2 VPS36 VPS25 CBX1 SNF8 CHMP1A CEBPD ELK1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 ESR1 CBFB RSPO3 FOXP3 AXIN1 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX PRDM1 RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM PNP ITPA NT5E NT5C NT5C1A XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades JUN PDGFB RASGRP1 RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB PRKG2 IL2 IL3 IL6 CDC14A FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA RAC1 KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 KALRN DNAJB1 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB SHC2 HSPB1 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 XPO1 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PAK1 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP SEPTIN7 PAK2 CDC14B ARL2 RAG2 RAG1 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A ETV4 RASA3 RASA4 RASA2 ABHD17C IGF2BP1 MAPK6 MAPK4 ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR CCND3 FNTB MAP3K11 MAPKAPK5 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 CDC42EP5 FGF3 CDC42EP3 FGF4 CDC42EP2 FGF6 FOXO1 FGF7 FGF9 IL6R RASA1 PAK3 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 CDC42 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 NCOA3 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA FOXO3 PTK2 HGF EREG BTC EPGN UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases USP17L1 RNF146 TOMM20 RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 USP3 IL33 USP2 MUL1 H2AC1 TGFBR1 CDC25A FKBP8 STAM2 TNKS ADRB2 FOXO4 ATXN7 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 NFKBIA TADA3 MDM2 MDM4 TAB1 RIGI USP37 USP33 USP34 PTEN ARRB1 ARRB2 POLB USP30 USP47 USP48 USP49 USP42 USP44 TRAF2 AXIN2 H2BC18 TRAF6 BIRC2 OTUB1 BIRC3 USP13 USP14 BECN1 USP15 USP16 SKP2 USP10 USP12 HGS MAT2B CDC20 USP18 USP19 TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 PSMD1 USP17L30 HIF1A RNF123 AR AXIN1 RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 PSMA1 SNX3 RHOT1 PSMA2 RCE1 UBA52 SIAH2 PSMD12 PSMD11 TADA2B CYLD PSMD14 H2AC25 H2AC21 PSMD13 WDR48 PSMA7 PSMB6 IFIH1 PSMB7 PSMB4 UFD1 PSMB5 IKBKG UBB TOMM70 PSMB2 PSMB3 UBC PSMB1 DDB2 RPS27A KAT2A PTRH2 WDR20 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 PSMC6 SEM1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 PSMC2 USP17L18 USP17L17 TP53 CCNA2 USP9X CCNA1 USP17L19 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 POU5F1 NANOG INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNG13 GNB2 KCNJ2 KCNJ8 KCNJ3 KCNJ11 GNB1 KCNJ4 ABCC8 ABCC9 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 KCNJ1 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression PTK6 PELP1 EPAS1 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism GUSB CD44 ABCC5 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HAS1 HYAL2 HEXB HAS3 HEXA CHP1 HAS2 SPAM1 HYAL1 HYAL3 HYAL4 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud ROBO2 GFRA1 EYA1 BMP4 SLIT2 FOXC2 ITGA8 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 WNT11 ITGB1 GREM1 SALL1 SIX2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism FOLH1 FOLH1B GOT1 ASPG NAALAD2 NAT8L ASPA SLC25A12 GOT2 ASNS SLC25A13 GADL1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX2 HSD17B4 AMACR ACOX3 ACOXL CROT CRAT ACOT8 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism SLC26A2 CSPG4 CHST3 CHST14 HSPG2 PAPSS2 SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B3GALT6 B4GALT1 B4GALT7 GPC1 GPC3 GPC2 ST3GAL3 GPC5 GPC4 NCAN GPC6 HEXB CHSY1 HEXA BGN DCN PRELP CHST6 BCAN OMD EXT1 VCAN KERA SDC1 OGN CSPG5 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A4 TOMT BCHE SLC6A3 ALDH2 COMT ACHE SLC22A2 SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 GORASP2 GORASP1 USO1 CCNB1 RAB2A CDK1 MAPK1 RAB1A RAB1B GOLGA2 CCNB2 BLZF1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 EPHX2 ALOX5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 NRAS PRKCZ SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 DDX5 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ ACE2 VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 HAVCR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 PARP10 PARP6 SFTPD IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C RPS10 STAT2 CHMP4B RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CHMP2B RPS3A RPS26 CHMP2A RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N CHMP3 CHMP6 HLA-H CHMP7 RPN2 HLA-B ZDHHC20 HLA-C TUSC3 ATG14 PRKCSH HLA-F RPN1 ZDHHC5 HLA-G HSP90AB1 HLA-E MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 SDC2 DDOST SDC3 MGAT4C ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 GPC5 SUMO1 GPC4 YWHAB GPC6 TRIM25 SDC1 IKBKE AKT1 IRF7 VHL NUP214 SFN YWHAZ ISCU UBA52 IFIH1 JAK1 TRIM4 IKBKG TOMM70 UBB RIPK2 UBC TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 FURIN VCP STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C ANO8 ANO9 NUP42 NUP85 ANO6 ANO7 TPR ANO4 NUP62 ANO5 UVRAG NUP88 MAP1LC3B ANO2 ANO3 NUP43 RAE1 HSP90AA1 ANO1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 TMPRSS2 NOD1 SRPK2 ANO10 GALNT1 NOD2 AKT2 PDPK1 NRP1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 PRMT1 SRPK1 HSPG2 TJP1 CHUK PTPN11 AGRN ST6GALNAC2 SIKE1 GSK3B ST6GAL1 CSNK1A1 ST6GALNAC3 ST6GALNAC4 CREBBP ST3GAL4 ST3GAL1 ZCRB1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 SNRPG TAB3 TAB2 SNRPE CTSL IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors JUN ZNF217 EBAG9 DDX5 RXRG GPAM CXCL12 POU2F1 NOS3 TBP S1PR3 CARM1 MMP2 MED1 GTF2A1 GTF2A2 MMP3 SCD FASN HBEGF HDAC1 HSP90AB1 PTGES3 CCND1 FKBP4 ATF2 RARG JUND CYP26A1 CYP26B1 TNRC6C MOV10 CYP26C1 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B XPO1 RARB AKT1 POLR2A POLR2B GATA3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 KAT2B KPNA2 GNG10 IGF1R PGR GNG12 CAV1 GNG11 GNG13 FKBP5 GNB2 PPARD KDM4B YY1 GNB1 DHRS4 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNG3 ESR1 GNG2 GNG5 RDH5 GNG4 GNG7 GNG8 HSP90AA1 EGF EGFR CDKN1B H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 PRKCZ H2AC8 CTSD H2AC6 H2AC7 HRAS H2BC17 RUNX1 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 RARA PIK3R3 PIK3CA CBFB H3C15 RXRA CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 NRAS H2AC20 CETP KDM3A HDAC3 KDM1A MAPK1 GNAT3 KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 SRF ABCA1 MAPK3 ABCG8 KDM4A MYLIP ABCG5 NR1H2 FABP5 KCTD6 APOC4 NR1H3 NCOR2 ARL4C EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ESR2 ABCG1 SRC PDK4 GNAI3 GNAI1 GNAI2 CALM1 AXIN1 NCOA2 NCOA3 PDHB NR5A2 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 CCNT1 KAT5 KANK1 MMP9 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 FOXA1 ALDH1A3 ZDHHC7 DHRS9 TLE3 ALDH1A2 TGFA PPID ALDH1A1 USF1 FOS CAV2 ALDH8A1 GREB1 FOXO3 ELK1 CHD1 PTK2 MMP7 EREG TFF3 UHMK1 TFF1 BTC ZDHHC21 EPGN CXXC5 AKT3 DLD USF2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors LTB4R2 OXER1 PTGER4 GPR17 PTGFR PTGER1 LTB4R TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR CYSLTR1 CYSLTR2 PTGIR C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RELA MAP3K7 UBA3 UBE2M PRKACG RAF1 PRKACA PRKACB CD209 CARD11 MALT1 ITPR1 RELB CLEC10A ITPR2 CLEC7A CLEC4A ITPR3 NFKBIA CARD9 CLEC4E MAP3K14 CLEC6A TAB1 PLCG2 PYCARD CLEC4C CLEC4D TRAF6 BTRC IL1B EP300 PAK3 HRAS PPP3CA PPP3CB PDPK1 CASP8 PPP3R1 UBE2N NFATC1 MUC13 NFKB1 NRAS CDC34 NFATC2 CHUK FCER1G IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 MUC12 PRKCD MUC15 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 MUCL1 PSMA1 MUC3A LYN MUC5AC PSMA2 MUC3B UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 NFKB2 PSMA7 MUC1 PSMB6 MUC2 PSMB7 PSMB4 MUC7 MUC4 PSMB5 MUC6 MUC16 IKBKG UBB MUC17 PSMB2 PSMB3 CREBBP MUC19 UBC PSMB1 MUC5B MUC20 MUC21 RPS27A ICAM2 ICAM3 FBXW11 UBE2V1 ADRM1 PSMC5 SYK PAK1 PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 PAK2 RPS6KA5 CUL1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A EIF4G1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IFNA2 OTUD5 IFNA8 ATG5 ATG12 RELA IFNA13 IFNA14 IFNA16 IFNA17 NFKB1 HSP90AB1 UBE2K ITCH IFNA10 PIN1 IFNA21 IFNB1 CHUK ISG15 PCBP2 IKBKB RIPK1 TBK1 IRF3 NFKBIA MAVS DHX58 RNF125 TKFC TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 TRIM25 IKBKE IRF7 SIKE1 TANK TRAF2 UBE2D1 HSP90AA1 TRAF3 TRAF6 UBA52 FADD CYLD NFKB2 IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG TOMM70 UBB CREBBP UBC RPS27A CASP10 NLRX1 EP300 NLRC5 UBA7 AGER RNF135 S100A12 MAP3K1 APP S100B SAA1 HMGB1 NFKBIB CASP8 UBE2L6 IFNA5 HERC5 IFNA4 IFNA7 IFNA6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR RUNX1 ELF1 CBFB IL3 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis PNMT DDC TH DBH DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts RXRA SLCO1A2 ABCB11 NCOA2 SLCO1B1 SLC27A5 FABP6 SLCO1B3 ABCC3 ALB SLC10A1 SLC10A2 STARD5 NR1H4 SLC51A NCOA1 SLC51B BAAT DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI2 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF18 TNFRSF1B TNFSF13 TNFRSF14 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells YAP1 ITGA5 GNAQ RELA NFKB1 ABL1 CHUK CAPNS1 CAPNS2 CAPN2 STAT1 PTPN1 IKBKG PPP2R1B ANXA2 PPP2R1A IKBKB PPP2CA PPP2R2A VCL PIEZO1 NFKBIA GNA11 IKBKE PTK2 ITGB3 ITGB1 ITGAV DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NFE2L2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR PSENEN NCSTN APH1B PSEN2 PSEN1 RELA NGFR NFKB1 ADAM17 TRAF6 APH1A SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 RELA PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 MAPK1 GNA13 GNGT2 F2RL2 GNA12 F2RL3 MAPK3 F2R GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 GNG10 F2 GNG12 GNG11 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling ERBIN STUB1 HBEGF HSP90AA1 ERBB2 EGF USP8 EGFR CDC37 UBA52 MATK PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 NRG1 AKT1 EREG NRG3 NRG4 NRG2 BTC AKT3 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases YAP1 ITCH PRDM1 ITPR1 ITPR2 ITPR3 NOS3 PRR5 CHD4 NTRK1 KIDINS220 CRK REST HGS VGF JUNB PRKCB RAC1 VAV3 CRKL VAV1 VAV2 MAPKAP1 TIAM1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ARHGEF7 MAPK7 APH1A PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 SOCS1 MDK WWOX ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 HIF1A FES POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K STAM POLR2L RALA WWP1 GTF2F1 GTF2F2 RAB4A PTPN18 PTPN12 PTPN2 AAMP MKNK1 SPRY2 ALK AHCYL1 PRKCE PGR MST1 MEF2A MST1R RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 USP8 STAM2 SPHK1 CDK5 ESR1 ADAM17 CYFIP2 PTPRU SH2B2 CMA1 FER TEC GRAP RAB4B KLB FLT3 IRS1 PPP2R1B PDE3B IRS2 PPP2R1A PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 NCK2 PTPRF FGF4 FGF6 NCK1 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 DIAPH1 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 ITGB1 TLR9 PIK3C3 TRIB3 ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 GFAP ATP6V1B1 ATP6V1A SHC1 PPP2R5D PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 SGK1 FGF20 THEM4 RHOA ATP6V1H PTPRJ MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 SRF ATP6V0A1 CDK5R1 MAPK3 PTPN1 INSR PTPN11 FGF16 CDC42 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FAM83B FGF10 HNRNPM HNRNPF SRC NRG1 DOCK3 GRIN2B HNRNPH1 DLG4 CALM1 DOCK1 FLT1 FLT4 KDR VEGFB VEGFC PTK2B VEGFD THBS1 PGF VEGFA ERBB2 ESRP1 MEMO1 CTNND1 CTNNA1 BAX CSK JAK2 SPRED2 RANBP9 SPRED1 CD274 IL2RG NELFB CHEK1 MMP9 BRAF MAP2K5 NCBP1 NRP2 NCBP2 CDH5 FRS3 TNS4 TNS3 LCK FYN HGF FGFRL1 FLRT2 FLRT1 CLTC CLTA AP2A1 NTRK3 AP2A2 NTF3 PDGFB AP2M1 RAP1B RAP1A PRKACG IGF2 PRKACA PRKACB IGF1 AP2S1 CXCL12 PTBP1 AP2B1 PLG STAT5A LAMA5 SH3KBP1 PXN LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 GRAP2 LAMC1 JAK3 HNRNPA1 PDGFRA KIT PTK6 HBEGF HDAC1 FLRT3 SIN3A NAB1 CTNNB1 COL6A2 NAB2 MET COL4A4 LYL1 F3 DNM2 COL6A1 ARC COL4A3 TRIB1 PTPRK TPH1 EPS15L1 ATF2 RRAD EPN1 ASCL1 SPRY1 PTPN3 EGR1 COL6A3 EGR2 EGR3 JUND COL4A5 EGR4 COL6A6 FOSL1 COL6A5 ID2 MLST8 ID1 MYCN MEF2C ID4 FOSB ID3 MYC CDK5R2 SPINT1 TGFBR3 HPN SPINT2 HGFAC MTOR YWHAB HSPB1 LRIG1 SOCS6 SH2B3 AKT1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 NCF2 NCF4 BRK1 MAPKAPK2 UBA52 MATK GIPC1 ANOS1 CYBB CYBA UBB RAPGEF1 UBC RPS27A RNF41 CUL5 MAPK14 MAPK11 PAK1 NCKAP1L WASF1 IRS4 PAK2 IGF1R CILP WASF2 CAV1 ERBIN BAIAP2 ABI2 FURIN PCSK6 ABI1 NGF PCSK5 SPP1 RICTOR ROCK1 ROCK2 ADAM12 STAT1 ELMO1 HSP90AA1 NEDD4 EGF CBL JUP EGFR CDC37 PLCG1 STMN1 RBFOX2 PDGFD SHB FGFBP3 FGFBP1 FGFBP2 ARF6 ALKAL2 ALKAL1 TIA1 TNK2 DOCK7 ADAP1 ESRP2 PTPRZ1 CSN2 TIAL1 SH2D2A PAG1 RANBP10 PTPRO PTN AXL PLAT FAM83D FAM83A MXD4 LTK EP300 THBS4 RASA1 THBS3 PRKCZ PAK3 BCAR1 NRP1 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 NRG2 ITGAV COL4A2 COL4A1 PTPRS SPARC STAT3 HDAC3 ITGA2 GABRG3 APOE GABRG2 COL9A1 GABRB3 COL9A3 GABRB2 COL9A2 GABRB1 NCOR1 GGA3 HDAC2 STUB1 STAT5B GABRQ GABRA1 GRB2 THBS2 ATF1 GALNT3 DNMT1 MAPKAPK3 MUC20 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 PTPN6 YES1 MEF2D STAT6 NTF4 PDGFRB S100B NTRK2 BDNF TGFA TAB2 FOS ELK1 PTK2 EREG BTC EPGN AKT3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HPGDS TBXAS1 PTGES PTGES2 PTGR2 CBR1 PTGIS PTGS2 PTGS1 CYP8B1 AKR1C3 PTGES3 PTGDS HPGD PRXL2B ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX BAX BID CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 CD22 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PTPN6 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME CYP2E1 UGT2B7 CYP2C9 UGT1A3 CYP2C8 ABCC2 CYP2C19 ACSM2B ABCC3 CYP2D6 SLC16A1 SLC22A7 UGT2B28 ALB CES2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 BCHE UGT3A1 UGT2A1 UGT1A8 GLYATL3 BSG UGT1A7 GLYATL2 UGT1A6 GLYATL1 ACSM2A CYP3A4 UGT2B10 ACSM5 UGT2B11 GLYAT UGT1A1 CES1 ACSM4 UGT2B15 UGT1A9 UGT2B17 UGT2B4 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer TP53 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection CLTC KPNA7 KPNA4 KPNA5 CLTA GBP1 KPNA3 CPSF4 TGFB1 EIF2AK2 ISG15 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 KPNA1 PABPN1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 NUP37 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 MLKL RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 CALR CANX RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 XPO1 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 HSPA1A KPNA2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNG13 CLTC CLTB WNT5B FZD7 WNT5A ROR1 GNB2 ROR2 CLTA GNB1 AP2A1 PRICKLE1 WNT1 FZD1 MAP3K7 GNB4 AP2A2 RYK FZD8 GNB3 GNB5 AP2M1 GNGT1 GNGT2 PRKG2 AP2S1 GNG3 SMURF2 ITPR1 ITPR2 GNG2 ITPR3 GNG5 AP2B1 GNG4 GNG7 GNG8 ARRB2 SCRIB VANGL2 DAAM1 PFN1 PARD6A PRKCB RAC1 DVL1 DVL2 DVL3 PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 RAC2 GNAO1 TCF7L2 TCF7L1 LEF1 TCF7 RHOA CTNNB1 TNRC6C MOV10 AGO3 AGO4 SMURF1 AGO1 AGO2 TNRC6A TNRC6B CAMK2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RAC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 WNT4 PSMC1 PSMC2 PRKCG GNG10 GNG12 GNG11 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 RB1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 SKP2 ANAPC15 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 FUCA1 MGAT3 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 B4GALT6 SEC22B B4GALT5 MAN2A2 LHB SERPINA1 SEC23A COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 MANEA TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B B4GALT2 TRAPPC3 B4GALT3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A B4GALT4 TRAPPC6B CGA SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 FUT8 NSF MAN2A1 CTSC MGAT5 CAPZA3 MGAT1 MGAT2 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A MGAT4C TMED2 MGAT4A SPTB DYNC1I1 MGAT4B B4GALT1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 ST6GAL1 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ST3GAL4 ANK1 AREG ST8SIA6 DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 ST8SIA2 TGFA ST8SIA3 YKT6 ARFGAP1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation MAPK1 RAPGEF1 RAP1A FRS2 NGF MAP2K1 MAP2K2 CRKL MAPK3 BRAF YWHAB RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MBD2 MAPK3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants UBC RPS27A FLT3LG CBL UBA52 FLT3 UBB MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN CSNK2A1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects APRT HPRT1 ADA TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs KIT HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 RNF8 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e DPM3 DPM1 DPM2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope DSG1 DSG3 FURIN PERP PCSK6 LCE6A IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KLK13 KLK14 LCE3E KLK12 LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A LCE1B KAZN LIPJ LIPN LIPM JUP PRSS8 PI3 LIPK PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 LCE1E LCE1F LCE1C CAPNS1 LCE1D LCE2B PKP4 LELP1 CAPN1 LCE2C LCE2A LORICRIN FLG SPRR2E SPRR2F DSG2 SPRR2G TCHH PKP1 KLK5 KLK8 PPL CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN SPRR1A SPRR1B DSG4 CASP14 LCE5A DSP PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds UGT2B7 GSTA3 GSTA1 COMT HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM MGST3 MGST1 MGST2 GSTP1 MTRR MAT1A NNMT CYP1A2 MAT2B AHCY SLC35D1 SLC35D2 SULT2A1 TPST2 TPST1 GSTM4 TPMT AS3MT AKR1A1 GSTT2 GSTT1 ESD GSTT2B UGT1A3 GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 MAT2A GSTA5 GSTA4 CHAC1 PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 ACSM1 BPNT2 ACSM2B BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 MTR HPGDS GSTZ1 GSTO1 NAT1 NAT2 GSTA2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 UGDH UGT2B4 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 MFAP5 BMP4 MFAP4 MFAP3 MFAP2 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 BMP10 LTBP4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP41 CEP43 DYNLL1 CKAP5 TUBA1A RPGRIP1L PRKACA MAPRE1 PAFAH1B1 DYNC1I2 MKS1 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 YWHAE CEP97 CC2D2A TUBB4B IQCB1 TUBB4A KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 YWHAG SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 RAB3IP CEP290 NINL RAB11A CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins ACOX1 HSD17B4 AGPS SCP2 ACAA1 PHYH TYSND1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria YWHAH YWHAZ SFN BCL2 AKT2 YWHAB PPP3CC BID YWHAE AKT1 PPP3R1 BAD YWHAQ YWHAG AKT3 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b MOGS STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B BCL2L1 CDKN1A GRB2 GAB2 FLT3 NOX4 PIM1 PTPN11 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP5B SYNJ1 INPP5A IMPA1 MTMR9 INPP4A IMPA2 MTMR7 INPP4B INPP5J MIOX ISYNA1 OCRL INPP1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 GLYAT VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance APOC4 LSR APOB VLDLR APOBR APOC1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism MRI1 ENOPH1 BHMT2 FMO1 BHMT ADI1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 MAT1A TST ETHE1 SLC25A10 CDO1 AHCY CBS MTAP CTH MTR GOT1 APIP MTRR TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 F9 PROC F10 PROS1 PROZ F2 BGLAP GAS6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System RELA ARPC1B ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 RAB9B IRAK1 NCKIPSD MGST1 C4A CAT RETN FUCA2 DNAJC3 RAC1 VAV3 CST3 PRKCQ UBE2N VAV1 VAV2 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 NFATC2 V1-11 CPB2 CFH V1-16 V1-13 MAPK8 C5AR2 CFI CDK13 CAPZA2 C5AR1 C4B_2 C2 ACTR10 C5 HSPA1B C6 SOCS1 C7 C9 CD19 IKBKB V2-8 V1-20 MYD88 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S UBE2D2 C1R UBE2D3 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 RAB3A POLR2E POLR2F POLR2H POLR2K DNAJC5 POLR2L KRT1 TOLLIP ACTB CSNK2B CNPY3 TLR8 CTSB TP53 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B NLRC4 RAB5C BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 ACTG1 FCAR ALAD FCGR3B PPP2R1B PGM2 PPP2R1A ACP3 SNAP29 PGM1 RNASET2 TNFRSF1B DYNC1LI1 PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 TXN DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PPP2R5D PRG3 DYNLL1 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 CHUK MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA DNASE1L1 PPP2CB CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CD93 CASP1 CD300A CASP2 IRAG2 ATAD3B OSCAR TYROBP DOK3 CRCP COPB1 ADGRG3 DPP7 MGAM POLR3GL HSPA6 GGH POLR3A POLR3B DNAJC13 ADA2 POLR3C IGF2R POLR3D POLR3E SELL TARM1 POLR3F POLR3G MAN2B1 MS4A3 POLR3H DDX3X TNFAIP6 POLR3K CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 NFKB2 ADGRE5 NAPRT ADGRE3 FGB HGSNAT DYNLT1 ATP6AP2 FGA PLAUR LRRFIP1 MMP8 MMP9 FGG CHI3L1 PDXK BIN2 FCN2 CLEC12A MVP FCN3 CAND1 CRP COLEC10 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN SKP1 PROS1 F2 CUL1 AP2A2 SLC15A4 RASGRP2 RASGRP1 RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB NPC2 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 LBP IGKV3-20 IGHV4-34 IGHV1-2 ITK IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 VTN IGLC2 BTRC IGKV3D-20 TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C AMPD3 IGKV5-2 APRT IGLC6 IGKV1-5 PNP IMPDH1 IMPDH2 LIMK1 PPP3CA EEF1A1 MYH9 PPP3CB UBE2L6 HERC5 PPP3R1 NFATC1 HLA-H HLA-B HLA-C HSP90AB1 IGHE HLA-E CDC34 DNM2 ATG7 CAB39 CTSS VAMP8 TLR6 HUWE1 IKBKE LAMTOR2 IRF7 LAMTOR1 TANK LAMTOR3 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 STBD1 CEP290 NFATC3 TUBB S100A1 CYBB CYBA RAB7A UBE2V1 UBA7 UBR4 PAK1 MEFV PSTPIP1 NCKAP1L SUGT1 WASF1 PAK2 WASF2 CALM3 CALM2 RASGRP4 BAIAP2 ATP8A1 ABI2 UBA3 ABI1 UBE2K ATP11B UBE2M ATP11A TIRAP CARD11 MALT1 ATP8B4 RELB CLEC10A CLEC7A CARD9 CLEC4A WIPF1 CLEC4E MAP3K14 WIPF2 CLEC6A DHX58 WIPF3 RNF125 TAX1BP1 RNF216 FCGR1A ARHGAP45 IQGAP1 ANO6 PLD1 IQGAP2 JUP ARHGAP9 WASL WAS STOM PAK3 MYO9B MAP2K1 COLEC11 HSP90B1 ITGAV FTH1 MASP1 FTL XRCC6 XRCC5 ITGAX DGAT1 FABP5 SIKE1 GPI CD36 HK3 KLRK1 PGAM1 KIR3DS1 DHX36 PRKDC FCER1A LAT2 NCR2 BCL10 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E NKIRAS2 LPO MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 TLR10 BCL2 TLR5 ALPK1 LRRC14 NLRX1 PELI3 BCL2L1 PELI2 PTPN6 NLRC5 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 STAT6 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB ELK1 POLR1C PTK2 POLR1D IFNA5 IFNA4 IFNA7 IFNA6 JUN IFNA2 IFNA8 AGPAT2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 CD209 GM2A NOS1 APEH ARSA FGR ASAH1 PECAM1 ITPR1 ITPR2 ITPR3 PSAP TKFC APOB MBL2 NOS2 NOS3 MME GLA P2RX7 CRK P2RX1 FADD IST1 CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 KPNB1 IL1B PELI1 TLR4 GSN TICAM2 TICAM1 PKP1 LY96 SDCBP HMGB1 CASP8 CASP5 CASP4 DSP DUSP4 DSG1 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 PRKCSH MAGT1 LTA4H NCSTN ADAM10 PSEN1 DNM1 GOLGA7 LGMN DDOST LPCAT1 ALOX5 DNM3 MAPK12 MAPK13 TRIM25 HPSE LYN BTK CYLD CNN2 CFL1 IFIH1 TRIM4 IKBKG ANXA2 TOMM70 RIPK2 MIF CAPZA1 AAMP PPIA RNF135 AHCYL1 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 NFKBIA MAVS CYFIP2 TAB1 RIGI TNFAIP3 HMOX2 SLC44A2 GLIPR1 TRAF2 TEC TRAF3 TRAF6 BIRC2 BIRC3 STK10 USP14 NOD1 NOD2 USP18 ORMDL3 PIK3CB TCIRG1 PTGES2 NCK1 TNIP2 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B CD180 ATP6V0E1 LY86 ATP6V1G2 EEA1 PDPK1 TASL RBSN IRF5 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 ATP6V0D1 FAF2 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS ATP6V0A2 PLD4 ATP6V1H MAPK1 PLD3 ATP6V0A4 PANX1 DHX9 ATP6V0E2 ATP6V1G3 ATP6V1D ALDH3B1 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PCBP2 PTPN11 PLD2 DEGS1 UNC93B1 TLR3 CKAP4 LRRC7 CALM1 DOCK2 DOCK1 MOSPD2 UBE2D1 MRE11 ARMC8 MYO5A FBXW11 OPTN RAB27A CEACAM1 SEM1 APP LAMP2 PPIE ARG1 SERPING1 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 SERPINA3 DEFB117 DEFB116 ORM1 FPR2 SLC11A1 SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 ORM2 DEFB110 TLR1 DEFB130A BPI QSOX1 PRTN3 DEFB130B S100A9 CAP1 DEFB4B S100A8 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PTAFR PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 ACLY ATG5 ATG12 SLC27A2 CTNNB1 ACAA1 ATF2 TREM2 SIGIRR IRAK3 MEF2C B4GALT1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 KCNAB2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 CASP10 ICAM3 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A CASP9 APAF1 CASP3 CFD C3 GZMM CFB VAPA CCT2 ROCK1 ZBP1 TREX1 DDX41 DTX4 TBK1 B2M IRF3 STING1 AP1M1 NLRP4 TRIM32 TRIM21 TRIM56 ELMO1 HEXB GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 FRK PLCG1 EP300 NDUFC2 NFKB1 PIN1 CHRNB4 ITGAL MUC12 MUC15 PTPN4 MUCL1 MUC3A MUC5AC MUC3B LGALS3 CFP MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 NEU1 MUC5B MUC20 MUC21 CTSA YES1 EEF2 MLEC CTSV CTSL CTSK MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 TYK2 JAK2 JAK1 IL6R MAP2K2 PTPN11 IL6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability HSP90AA1 JUP CTNND1 THEM4 CTNNA1 RICTOR CTNNB1 CDH5 MLST8 AKT2 PAK1 PAK3 MTOR RAC1 VAV3 NOS3 PRR5 PDPK1 PAK2 AKT1 VAV1 CALM1 CAV1 VAV2 MAPKAP1 AKT3 TRIB3 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB GLYCTK KHK ALDH1A1 TKFC REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC VCL PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis CDON ABL1 CTNNA1 CTNNB1 MAP2K6 CDC42 CDH2 NEO1 NTN3 CDH4 BNIP2 MEF2C CTNNA2 MYOG SPAG9 MEF2B MAPK14 MYOD1 MAPK11 MYF6 TCF4 MEF2D CDH15 MYF5 TCF3 TCF12 MAPK12 MEF2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SMARCB1 SMARCD1 SMARCD2 SMARCD3 PCGF5 HIPK2 SMARCC1 SMARCC2 RYBP ARID2 YAF2 SMARCE1 ACTL6A BMI1 CBX6 EP300 RING1 AUTS2 CSNK2A1 CSNK2A2 RNF2 SMARCA2 RUNX1 ACTL6B SMARCA4 CSNK2B CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 CBFB ARID1A ARID1B PBRM1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PLK1 PSMA6 PSMA3 PSMA4 HSP90AA1 PSMA1 CCNB1 PSMA2 CDKN1A UBA52 PSMD12 HSP90AB1 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 MAPRE1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A GTSE1 FKBPL ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 CCNB2 PSMD2 TP53 PSMD3 PSMD1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation GLI2 IHH HDAC4 CBFB BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion NEDD4L CHMP3 CHMP6 CHMP7 UBA52 UBB UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A PPIA VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 PDCD6IP MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MT-ND4L GFM2 MRRF MT-CYB MTRF1 MTRF1L MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 UBA52 IFNA10 IFNA21 IFNB1 EIF2AK2 IFIH1 JAK1 UBB CREBBP UBC TYK2 RPS27A STAT2 EP300 IRF3 CUL5 IFNAR1 MAVS RIGI ELOB ELOC RBX1 TRIM25 IFNA5 IFNA4 IFNA7 IFNA6 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNJ2 KCNJ4 KCNJ14 KCNK5 KCNK2 KCNK3 KCNK12 KCNK4 KCNK15 KCNK9 KCNJ12 KCNK6 KCNK7 KCNK1 KCNK10 KCNK13 KCNK16 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 PHOSPHO1 LPIN1 LPIN2 LPIN3 CHKB ETNPPL CEPT1 CHKA ETNK2 SELENOI PISD ETNK1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME SLCO1A2 SLC22A8 ABCG2 ALB SLC22A1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling NRG1 HBEGF PIK3R1 PIK3CA NRG3 EREG NRG4 BTC NRG2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling GNAS ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System PRL FGF10 TGFA AREG EGF MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 MAPK3 BRAF UBB GALNT3 PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 FRS3 RPS27A FGF4 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling SOS1 IL15RA STAT5A STAT5B IL15 SHC1 STAT3 IL2RB SOS2 GRB2 JAK3 JAK1 GAB2 IL2RG PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation CACNG4 FGF14 FGF13 FGF12 FGF11 SCN9A SCN11A CACNG6 CACNG7 SCN10A SCN8A CACNA1C RANGRF SCN5A CACNB1 SCN4A SCN4B SCN7A CAMK2B SCN1B SCN1A CAMK2D CAMK2A CACNA2D2 CACNB2 SCN3B SCN3A CACNG8 CALM1 CAMK2G SCN2A SCN2B SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog EVC2 IQCE EFCAB7 SEL1L EVC BOC GAS1 ADCY9 DRC4 CDON ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L CUL3 PRKACA KIF7 PRKACB WDR35 IHH IFT88 VCP SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 DERL2 ERLEC1 SMURF2 OS9 ADAM17 P4HB ARRB1 ARRB2 GNAS GLI1 SUFU BTRC NUMB PRKAR1B PRKAR2B PRKAR1A PRKAR2A NOTUM SPOP GLI3 GLI2 SMURF1 GPC5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 OFD1 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 DISP2 PSMC2 ULK3 SCUBE2 GRK2 SKP1 DZIP1 SPOPL SYVN1 CUL1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 TRIM24 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 ZMYM2 FGFR1OP2 GAB2 PIK3CA MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A AJUBA YWHAG PLK1 HSP90AA1 CCNB1 CEP57 CETN2 CEP164 UBA52 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 BTRC CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 PPP1CB HAUS5 CSNK1E UBB PPP2R1A TUBG1 HAUS2 HAUS1 CPAP UBC AKAP9 RPS27A BORA CEP63 SFI1 FBXW11 SDCCAG8 OPTN DCTN2 SSNA1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 SKP1 CCNB2 ODF2 CEP152 NEDD1 ALMS1 CUL1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes ZNF420 TNFRSF10C PRELID3A BNIP3L TNFRSF10B TNFRSF10A PERP PRELID1 TNFRSF10D TMEM219 NLRC4 BAX BID BIRC5 TP63 PPP1R13B FAS CREBBP CHM BBC3 RABGGTB RABGGTA NDRG1 BCL6 CASP10 PMAIP1 STEAP3 AIFM2 TP53AIP1 TP53INP1 CRADD TP53I3 IGFBP3 TP73 TP53 CASP6 ATM CASP1 TRIAP1 CASP2 PIDD1 TP53BP2 APAF1 BCL2L14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 IGLV2-11 IGLV1-40 HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LRP1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4C GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D PLA2G4E PLA2G4A PLA2G4B CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD MC2R POMC DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins GSN SPTAN1 DBNL PLEC CASP8 CASP6 ADD1 GAS2 CASP7 MAPT CASP3 VIM REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSF1 HSPA2 MAPK3 HSPA1B HSPH1 YWHAE NUP205 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA8 RPA1 RPA2 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation MIB2 ITCH UBE2L3 BTRC RNF111 UBE2V2 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF126 CDC34 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SOCS1 HACE1 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 LRRC41 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 KLHL5 PSMA5 RLIM PSMA6 TRIP12 PSMA3 KBTBD7 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 RNF19B UBE3A PSMD12 UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 NPEPPS PSMD13 RNF19A PSMA7 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 UBE2E3 TRIM4 PSMB4 FBXO17 PSMB5 FBXO15 UBE2E2 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 RNF14 KBTBD13 CUL3 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 RBBP6 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 SMURF2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 ASB2 ASB3 SKP2 ASB1 CDC20 SOCS3 SH3RF1 FBXO32 MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 FBXL21P SEM1 SKP1 CUL1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RRAS RAC1 PLXNB1 MET RND1 ARHGAP35 SEMA4D RHOA PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling XIAP RACK1 TRAF1 ULK1 MAP3K7 USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 RBCK1 NSMAF SMPD3 SMPD2 CHUK IKBKB RIPK1 SHARPIN TBK1 ADAM17 TAX1BP1 TAB1 UBE2D2 UBE2D3 TNFAIP3 RNF31 IKBKE SPATA2 TNFRSF1A OTUD1 STUB1 UBE2L3 TRAF2 BAG4 UBE2D1 MAPKAPK2 UBA52 BIRC2 FADD BIRC3 CYLD OTUD7B IKBKG UBB UBC RPS27A USP21 TNF OPTN OTULIN TRADD TAB3 TAB2 CASP8 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK6 KCNK7 KCNK1 KCNK2 KCNK3 KCNK10 KCNK4 KCNK9 KCNK13 KCNK16 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling RELA MAP3K7 PTPN22 CARD11 MALT1 NFKBIA PTEN PLCG2 VASP ITK TRAC CD3G CD3E TRAF6 PLCG1 CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 PTPRC ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 CD4 HLA-DRB1 PAG1 HLA-DQB2 LAT PIK3CB CD101 HLA-DQB1 NCK1 WAS PAK3 PDPK1 PRKCQ PIK3CA UBE2N PIK3R2 PIK3R1 NFKB1 CDC34 PTPRJ EVL CHUK IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 ZAP70 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 INPP5D PSMA2 TRAT1 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 CSK PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB RIPK2 PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TAB2 PAK2 CUL1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE MMAA PCCA MMUT PCCB AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production RACK1 NSMAF SMPD3 SMPD2 TNF TNFRSF1A DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade RAC2 LYN RHOG PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 RHOA RHOB GP6 FCER1G LCP2 PTPN11 PIK3CB CDC42 LAT PDPN MPIG6B CLEC1B PTPN6 PRKCZ SYK RAC1 LCK FYN VAV3 PDPK1 PLCG2 PIK3R3 PIK3CA VAV1 VAV2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template PCNA UBA52 NPLOC4 POLH USP10 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1 TGIF2 CCNK SERPINE1 FURIN CCNC HDAC1 CDKN2B UBA52 MAPK1 COL1A2 CCNT1 TFDP1 MAPK3 TFDP2 UBB UBC CDK8 SP1 SMAD2 RPS27A SMAD4 CDK9 YBX1 SMAD3 EP300 SMAD7 MYC JUNB RNF111 MEN1 WWTR1 E2F4 CCNT2 E2F5 RBL1 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD MAT1A MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation TYK2 JAK2 JAK1 MAP2K1 IL6R MAPK3 CDK1 PTPN11 IL6 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis NEU1 GLB1 CTSA FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation FGF18 FGF1 FGF9 FGF20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism RXRA OSBP NCOA2 AMACR SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 SLC51A NCOA1 SLC51B CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 SLCO1A2 OSBPL1A ABCB11 AKR1C1 FABP6 ABCC3 AKR1C2 ALB AKR1C4 SLC10A1 SLC10A2 CYP8B1 STARD5 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2E1 CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 PSIP1 HMGA1 OPSINS%REACTOME%R-HSA-419771.3 Opsins OPN1MW OPN1LW RHO OPN1SW OPN4 OPN3 RRH RGR OPN5 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type CSPG4 AGRN B4GALT7 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 PATL1 EDC3 EDC4 DCP1B XRN1 DCP2 DCP1A LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DDX6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells HNF1A MAFA RFX6 IAPP FOXA3 GCK FOXO1 PDX1 INS NKX6-1 AKT2 PAX6 SLC2A2 HNF4G AKT1 FOXA2 NEUROD1 NKX2-2 AKT3 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing SNRNP200 SNRPD2 SRSF6 SNRPD1 SRSF7 SNRPD3 SNRPB PRPF8 ZMAT5 RNPC3 ZRSR2 DDX42 YBX1 SRSF1 DDX23 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E POLR2F POLR2G POLR2H SF3B1 POLR2I POLR2J POLR2K POLR2L GTF2F1 SNRNP40 GTF2F2 PDCD7 SNRNP48 EFTUD2 NCBP1 NCBP2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRPG SRSF2 SNRPE SNRNP25 SNRPF CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN TNKS2 TNKS FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm SOX17 SMAD2 SMAD4 GSC SMAD3 MIXL1 TCF7L2 CDH1 GATA6 TBXT EOMES CXCR4 CTNNB1 GATA4 FOXA2 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway MAP3K7 TRAF6 BIRC2 BIRC3 CYLD ITCH CHUK NOD1 MAP2K6 NOD2 IKBKG RIPK2 IKBKB IRAK1 UBE2V1 CARD9 AAMP MAPK14 IRAK2 MAPK11 TAB1 TAB3 TNFAIP3 TAB2 MAPK12 CASP8 MAPK13 CASP1 CASP4 CASP2 CASP9 UBE2N GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 TAS2R16 FZD8 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 TAS2R46 RXFP4 MRGPRD FZD10 RXFP1 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R SSTR1 CGA SSTR2 WNT16 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 PTHLH CNR2 CNR1 TSHR ACKR1 C5AR2 C5AR1 C5 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 TSHB PF4 TAS1R2 TAS1R1 TAS1R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 LHB ADORA2B GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CRH WNT3 WNT8A WNT8B NPY CXCR1 CXCR2 OPRM1 OPRK1 POMC CXCL1 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CCR5 CXCR6 CCL7 CXCR4 CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 EDN1 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH CYSLTR2 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 HTR2B HTR2C ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 WNT3A WNT9A C3 SMO PTCH1 OPN1LW OXER1 OPN1MW RHO RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 SAA1 MC2R DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth COL4A2 CACNA1D NCAM1 COL4A1 SOS1 NRAS MAPK1 COL6A2 COL4A4 COL6A1 COL4A3 MAPK3 PTPRA CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 SPTB COL6A5 AGRN NCAN SPTBN4 SPTBN5 SPTBN2 PRNP ARTN GFRA1 GFRA2 GFRA4 NRTN CACNA1C SPTAN1 SPTA1 CACNA1S PSPN GDNF CNTN2 ST8SIA4 HRAS FYN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PTK2 SPTBN1 RPS6KA5 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses IFNA2 IFNA8 IFNA13 MAP3K7 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 STAT1 SAR1B NLRP3 SEC23A TBK1 B2M LARP1 IRAK1 IRF3 IFNAR1 STING1 MAVS HLA-A TLR1 TKFC G3BP1 TAB1 G3BP2 RIGI MBL2 CNBP TLR2 NUP205 POM121 NUP107 SFTPD NUP188 IL17RC IL17RA SEC24B AAAS NLRP12 NUP160 SEC24A IL17F POM121C IL17A NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 TRAF3 RANBP2 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C TLR7 NUP37 NOD1 NOD2 STAT2 UBE2N PIK3C3 MASP1 HLA-H PIK3R4 HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E CHUK PTPN11 IKBKB TRIM25 IKBKE IRF7 SIKE1 NUP214 IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 CREBBP TYK2 UBE2V1 PTPN6 IRAK2 RNF135 TAB3 TLR8 KPNA2 TAB2 IFNA5 IFNA4 IFNA7 IFNA6 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R2A BANF1 SIRT2 CCNB1 VRK1 CDK1 ANKLE2 LEMD2 EMD LBR LMNB1 CCNB2 KPNB1 LEMD3 PPP2R1A SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy TUFM UVRAG MAP1LC3B VPS41 VPS33B VPS39 VPS18 VPS45 VPS11 VPS16 VPS33A ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity RPS6KA1 HDAC1 LEF1 ZIC1 FOXD3 MAPK1 HINT1 TFE3 MITF TFEC ALX3 TBX3 CTNNB1 MAPK3 EDNRB EPRS1 ID1 CDH1 UBE2I SUMO1 PAX3 YWHAB YWHAE XPO1 SNAI2 GSK3B TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 YWHAZ POMC RARS1 WNT3A SOX10 LARS1 MARK3 AIMP1 AIMP2 QARS1 MARS1 MC1R MC4R DARS1 EEF1E1 MC3R CREBBP KARS1 POU3F2 IARS1 TFEB EP300 MC5R SOX2 SOX9 SIRT1 KIT AKT3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 DVL3 CCDC88C CXXC4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing OGG1 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli YAP1 COX5B COX5A RELA COX6C COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C IL6 YWHAE PRR5 EED CAT PDIA6 IGFBP7 SOD2 WFS1 CARM1 PRKCI DNAJC3 MED1 MAPKAP1 PRDX2 PRDX1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 DNAJA4 DNAJA2 CAPZA2 FKBP4 ACTR10 HSPA1B IKBKB SQSTM1 UBE2D2 UBE2D3 HIF3A LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP CDKN2B CSNK2A1 IGFBP1 CSNK2A2 CSNK2B TP53 GNG10 PGR GNG12 GNG11 GNG13 FKBP5 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 MAP2K6 PRDX6 MT2A MT1A MT1M MT1F MT1G MT1H MT1X MT4 MT1B MT3 MT1E GNG3 GNG2 GNG5 CLEC1B GNG4 GNG7 GNA11 GNG8 GSTP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 SMARCD3 NUP210 HMGA1 CACNG7 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 RBBP4 NUP37 RBBP7 TXNRD1 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 COX7A2L TXN RPS27 ITGB1 CITED2 VENTX PPP2R5B DYNLL1 DYNLL2 HBB NFYA NFYB NFYC CHUK DYNC1I2 BMAL1 PPP2CA COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 HM13 EIF2AK3 NOX4 FLT4 KDR HSPA6 HSPD1 VEGFA TLN1 VCL CDH5 PIEZO1 FYN SKP1 CCNA2 CCNA1 CUL1 CXCL8 MTF1 NUDT2 CREB3L3 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 CHD6 PRKACG GPX3 GPX6 PRKACA GPX5 PRKACB GPX8 GPX7 BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 TRPV4 BTRC RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A GCN1 RPS16 WDR59 RPS19 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT DEPDC5 RPS10 RPS13 KPTN WDR24 RPS12 SH3BP4 RPS9 RPS7 FNIP1 RPS8 FNIP2 PRKAR1B KICS2 RPS5 PRKAR2B CASTOR1 RPS6 PRKAR1A CASTOR2 RPSA PRKAR2A RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 CACNB2 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 HSP90AB1 PRKAA2 SEC31A RPTOR CALR MLST8 SLC38A9 ID1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD AKT1S1 IKBKE LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NCF1 NCF2 NCF4 BAG4 ACTR1A CYBB CYBA DCTN2 CUL7 DCTN3 PGRMC2 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A HSPH1 HYOU1 HBA2 RAMP2 CALCRL ADM ITGB3 HSP90B1 ITGAV ITGA5 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 BMI1 RPL22 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RNF2 RPL12 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 MAP2K3 MAP2K4 CREBBP MAPKAPK3 SP1 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 MAP2K7 MAPK10 FOS FOXO3 PTK2 AKT3 HIKESHI JUN CCAR2 DNAJC2 CXXC1 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 ADCY9 BAG5 DNAJB6 ADCY4 BAG2 ADCY3 BAG3 ADCY2 BAG1 ADCY1 HSPA4 ST13 ADCY8 ADCY7 HSPA7 HSPA12A ADCY6 HSPA12B ADCY5 IFNB1 CSRP1 SNCB PECAM1 GCLC GCLM APOB NOS3 GSK3A P2RX7 GNAS CDKN2D CDKN2C DNAJB11 IL1A FBXL17 BACH1 TLR4 SLC7A11 LY96 OMA1 MAPK7 ADD1 ATF6 CRYAB MAP3K5 DELE1 HERPUD1 MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 KEAP1 AR NRF1 NPLOC4 RPLP0 UBXN7 DPP3 HSPA9 UFD1 IKBKG ANXA2 TALDO1 SOD1 PIK3CD CAPZA1 FKBP14 GOSR2 GPX1 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 KLHDC3 DDX11 WIPI1 YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP NLRP3 ESR1 NFKBIA MDM2 MDM4 GJA1 HMOX2 PKN2 STIP1 PIK3CB TCIRG1 CAPZB AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 PDPK1 PIK3CA ATP6V1B2 EPO TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 CACNA2D1 PIK3R2 ABCG2 ATP6V1H MAPK1 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MAPK3 PTPN1 CACNB1 CACNB3 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 HSPE1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN PPP2R2A RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 ATM ATR HSPA5 HSBP1 HSF1 ATP7A DEFA5 CAPNS1 CAPNS2 CAPN2 ATOX1 STOML2 PHB2 YME1L1 P2RY2 CDKN1A CDKN2A SIN3A CDK2 CTNNB1 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 ATF3 ATF4 TNRC6C MOV10 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B PSMD8 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 NUP214 DIS3 IDH1 PRKCD PSMA5 PPARGC1A PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 DCP2 PSMD12 SERP1 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 SIRT1 HSPA1A SIRT3 MMP14 PPARA CYCS SPP1 RICTOR CUL3 STAT1 TRIM21 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 HIGD1A H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KDM6B H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 NFKB1 H2AC20 HDAC3 NRIP1 COX4I1 COX4I2 TBL1X NCOA1 ARNT NCOR2 NCOR1 TBL1XR1 CRTC2 CRTC3 CRTC1 CLOCK NPAS2 HELZ2 RAI1 CHD9 TGS1 MEF2D COX7B GFPT1 COX7C EDEM1 COX8A SYVN1 COX8C INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling SOS1 SHC1 IL5 IL3RA PIK3R2 INPP5D IL2RB PIK3R1 JAK3 JAK2 JAK1 IL2RG CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 INPPL1 GAB2 PIK3R3 PIK3CA IL2RA IL5RA CSF2RB CSF2RA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex UBC TAB3 RPS27A TAB2 MAP3K7 TRAF6 UBA52 IRAK2 UBB TAB1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors HCAR3 HCAR1 HCAR2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants ERBIN HSP90AA1 ERBB2 CDC37 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor GNG13 GNB2 GNB1 GNAS GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNG10 PTGIR GNG12 GNG11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD MMACHC MMADHC DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis RIPK1 RPTOR MLST8 PIK3R4 NFKBIA ATG14 RETREG1 MTOR RICTOR BECN1 TAOK1 PRR5 DAXX NFKBIB PIK3C3 MAPKAP1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK H2AC20 ERCC6 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MYBBP1A ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs BRCC3 UBA52 H2AC20 STAM H2AC1 PSMD14 H2AC25 H2AC21 STAMBP ABRAXAS1 BRCA1 BABAM1 BABAM2 ABRAXAS2 UIMC1 UBB NLRP3 BARD1 UBC H2AC19 H2AC14 RPS27A KAT2B EP300 H2AC8 H2AC6 H2AC7 STAMBPL1 H2AC17 H2AC12 MYSM1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells KLF4 NR5A1 DPPA4 SMAD2 FGF2 SMAD4 STAT3 SALL4 POU5F1 SOX2 NANOG PRDM14 FOXD3 CRIPTO PBX1 LIN28A ZIC3 HIF3A ZSCAN10 EPHA1 EPAS1 SALL1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM KCTD6 RUNX1 ESR1 CBFB AXIN1 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors FSHR CGA GPHA2 LHB TSHB GPHB5 LHCGR TSHR GNRH2 GNRHR2 GNRH1 FSHB GNRHR DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands DLL1 SIN3A BDNF CRH HDAC1 SST SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 NTRK1 STAT3 NGF NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 PDYN POMC GNGT2 GNG10 OPRM1 GNG12 GNG11 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 CD9 ZP3 ZP2 ZP4 HVCN1 SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors LPAR4 GPR17 P2RY12 P2RY6 P2RY13 P2RY10 P2RY2 P2RY11 P2RY14 P2RY1 P2RY4 LPAR6 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 FGF9 NRAS FGF20 HRAS FGF23 FRS2 PTPN11 FGF16 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB PDPK1 AKT2 THEM4 TRIB3 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMA5 LAMA2 DRP2 DMD LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 UTRN SNTG2 DAG1 SGCE SGCD AGRN SGCA SGCB SGCG SNTA1 SGCZ DTNA DTNB SSPN SNTB1 SNTB2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBC GBP1 RPS27A UPK1A EPCAM UBA52 HBB GBP2 GBP6 UBE2D2 GBP4 HBA2 CASP4 CALM3 CALM2 CALM1 UBB TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TRAF2 LTA TRAF3 TNFRSF12A TNFSF12 MAP3K14 BIRC2 TNFRSF13C TNFRSF11A BIRC3 CD40LG LTBR LTB TNFSF13B TNFSF11 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression RXRA NCOA2 SERPINE1 NCOA6 SMARCD3 TBL1X CARM1 BMAL1 NCOA1 CLOCK NPAS2 HELZ2 CREBBP BHLHE40 CHD9 BHLHE41 NAMPT KLF15 TBL1XR1 AVP NOCT MED1 TGS1 F7 BMAL2 PPARA REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors SFN YWHAZ FOXO6 FOXO3 FOXO1 AKT1 AKT2 FOXO4 YWHAQ YWHAG YWHAB AKT3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation MET HGF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency ACAT1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis CHST2 B4GALT4 CHST3 B3GNT3 ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 PRELP CHST6 OMD KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis PPIA BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol DDX21 NOP56 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 PELP1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 DDX49 RPS28 DDX47 RPS29 WDR3 FCF1 RPS20 FAU RPS21 PWP2 RPS24 RPS27 RPS23 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 RPP30 UTP25 HEATR1 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 RPP38 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 RPP21 UTP4 RPP25 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 RPP40 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPP14 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L DIS3 RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EBNA1BP2 EXOSC7 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E NOB1 EXOSC4 RIOK2 RIOK1 TEX10 SENP3 EXOSC9 MTREX GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 NCL PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines DHFR SLC46A1 SHMT1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 MTHFD1L MTHFD2 SHMT2 MTHFD2L SLC25A32 FOLR2 SLC19A1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins APBB1IP SOS1 TLN1 FN1 SRC RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate TBX6 POU3F1 WNT3A ZEB2 SOX2 FGF8 ZNF521 SOX1 GBX2 OTX2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD PRELP OMD KERA ACAN OGN ST3GAL3 LUM GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XRCC1 POLE4 CUL4A RPA3 PPIE POLE2 POLE3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex H2BC9 H2AZ2 H4C9 H2BC8 BCL9L H2BC5 RUVBL1 H2BC3 H3-4 PYGO1 TCF7L2 H2BC1 BCL9 PYGO2 TCF7L1 HDAC1 H2AC20 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 ASH2L MYC TRRAP DPY30 WDR5 CDC73 AXIN2 LEO1 RBBP5 KAT5 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 TERT EP300 H3-3B MEN1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 SMARCA4 RUNX3 H2BC13 H2BC14 TLE3 H2AJ H2BC15 H2BC11 H3C15 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF NTRK3 LRRC4B IL1RAPL2 PPFIBP1 PPFIBP2 PPFIA1 PPFIA4 SLITRK3 PPFIA3 PPFIA2 SLITRK5 SLITRK2 SLITRK1 IL1RAPL1 SLITRK4 SLITRK6 PTPRD DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA ABAT ALDH5A1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 MAPK14 GNG7 GNA11 GNGT1 GNG8 GNGT2 GNG10 P2RY1 PLA2G4A GNG12 GNG11 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones DUOX1 TPO TPH2 IYD ASMT DUOXA1 CGA AANAT DUOXA2 DUOX2 TSHB PNMT DDC TH DBH DIO1 TPH1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy ACY1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) GUSB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) GRM8 TAS2R4 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GABBR2 TAS2R50 GABBR1 TAS2R19 TAS2R42 TAS2R45 TAS2R40 TAS2R60 TAS2R41 TAS2R43 CASR TAS2R46 TAS1R2 TAS1R1 TAS1R3 TAS2R30 TAS2R7 TAS2R31 GRM1 GRM5 TAS2R38 TAS2R8 TAS2R39 TAS2R20 GPRC6A TAS2R9 GRM3 GRM2 GRM4 GRM7 TAS2R1 GRM6 TAS2R3 TAS2R5 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER ACTR5 RAD23A YY1 ACTR8 RUVBL1 RAD23B PARP1 CETN2 UBA52 INO80 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ACTB UBB TFPT ACTL6A UBC RPS27A DDB2 PARP2 DDB1 COPS7B XPC COPS7A CUL4A COPS3 RBX1 COPS6 COPS5 MCRS1 NFRKB COPS8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations DAG1 POMT2 POMT1 POMGNT1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling ERBIN HSP90AA1 ERBB2 CDC37 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling YWHAZ SOS1 CRK STAT5A STAT5B SHC1 IL5 LYN IL3RA PIK3R2 CBL INPP5D IL2RB PIK3R1 TEC BLNK JAK3 JAK2 PRKACA JAK1 IL2RG PTPN11 CSF2 PIK3CB RAPGEF1 PIK3CD PTPN6 IL2 YES1 HCK IL3 SYK FYN INPPL1 GAB2 PIK3R3 CRKL PIK3CA IL2RA IL5RA VAV1 CSF2RB CSF2RA EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation EEF1B2 EEF1A2 RPL4 RPL5 RPL30 RPL3 EEF1G RPL32 RPL31 RPLP1 EEF1D RPL34 RPL10L EEF1A1P5 RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DBT DLD REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL CRIPTO ACVR1B LEFTY2 ACVR2B LEFTY1 ACVR2A CRIPTO3 ACVR1C DAND5 CFC1 CER1 NODAL SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR EIF2AK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages PRL FGF10 LAMA5 FGF2 LAMA2 LAMB3 AREG LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN TGFA REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 EHMT1 SETD9 UBC RPS27A PRMT5 EP300 UBA52 MDM2 MDM4 CHEK2 TTC5 JMY SMYD2 TP53 ATM KMT5A UBB EHMT2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FZR1 BTRC PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPOP PSMD12 PSMD11 PSMD14 PSMD13 CCND1 CUL3 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 CSNK2B PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 YWHAG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 RIPK3 CASP8 MLKL WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 DVL2 CSNK2B DVL3 CSNK2A1 CSNK1E PIP5K1B CSNK2A2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling WWP1 UBC RPS27A NEDD4 UBA52 SRC UBB ITCH SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R4 GNG13 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism GYG1 GBE1 UBA52 PYGM GYS1 GYS2 PHKG1 PHKG2 GYG2 EPM2A AKR1E2 PHKA1 PHKB PHKA2 PPP1R3C NHLRC1 GAA UBB PYGB PYGL UBC PGM1 RPS27A UGP2 AGL CALM1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling GNG13 GNB2 HBEGF GNB1 GNB4 PIK3R2 GNB3 PIK3R1 PRMT1 GNB5 NRAS GNGT1 MAPK1 GNGT2 GNAT3 CCND1 SPHK1 SRF MAPK3 GNG3 ESR1 GNG2 GNG5 GNG4 GNG7 ESR2 SRC GNG8 GNAI3 NOS3 XPO1 GNAI1 GNAI2 AKT1 CALM1 HSP90AA1 EGF EGFR CDKN1B S1PR3 MMP9 STRN MMP2 BCL2 AREG AKT2 PRKCZ HRAS MMP3 ZDHHC7 PDPK1 TGFA FOS CAV2 FOXO3 ELK1 IGF1R GNG10 MMP7 PTK2 EREG PIK3CA PIK3R3 UHMK1 BTC ZDHHC21 CAV1 GNG12 EPGN AKT3 GNG11 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling PITPNA TRPC7 TRPC5 DCC TRPC6 NTN1 TRPC3 TRPC4 TRPC1 PLCG1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction NEB DMD MYH3 MYH8 MYH6 TNNI1 TNNI2 TNNI3 TMOD3 TPM4 TPM3 DES VIM ACTN3 ACTN2 MYL4 MYL1 MYL2 MYL3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TPM2 TMOD4 TTN TPM1 TMOD2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA YY1 TFAP2A VEGFA ERBB2 TFAP2B ESR1 EGFR TFAP2C CGB8 TGFA KIT ATAD2 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RBM8A PRKACG PRKACA CXCR4 PRKACB ETF1 GSPT2 GSPT1 CXCL12 UPF3A CAP1 UPF2 LDB1 VASP CAP2 ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RAC1 RPSA PRKAR2A RPS3A RPS26 RPS25 PPP3CB RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 SOS2 HOXA2 FLRT3 ZSWIM8 MSI1 LHX3 LHX2 LHX4 LHX9 COL4A5 NELL2 GPC1 PSMD8 PSMD6 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 CUL2 PSMD1 PRKCA ROBO2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ARHGAP39 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SLIT1 UBC PSMB1 SLIT3 RPS27A ADRM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABL2 EIF4G1 PAK2 PAK4 ABL1 ISL1 DCC NTN1 USP33 SRGAP3 SRGAP1 NCK2 NCK1 PFN1 PFN2 PAK6 PAK3 PAK5 MYO9B SRGAP2 NRP1 EIF4A3 RPS27 SOS1 MAGOH RPL4 RHOA RPL5 RPL30 RPL3 RPL32 RPL31 EVL RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 CDC42 RPL38 RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 CLASP1 RPL22 CLASP2 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 SRC RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 AKAP5 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 CASC3 NCBP1 NCBP2 SEM1 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g ALG12 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 PSMD1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions KDELR1 YBX1 LYN NCL FURIN CLINT1 TSG101 GBF1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L CCNT2 TAF4B ELOB ELOC CCNH POLR2A CDC73 TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 TAF15 GTF2H2 LEO1 TAF12 GTF2H3 TAF13 SUPT5H PAF1 GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 TAF10 SUPT6H IWS1 EAF1 EAF2 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair LIG1 FEN1 PARP1 PARP2 POLB PARG APEX1 ADPRS FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion GNA14 GNAQ CD36 GNA15 PLCB3 PLCB1 FFAR1 PLCB2 ACSL4 ACSL3 GNA11 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification RCC1L RPUSD4 NGRN RPUSD3 TRMT61B TRUB2 MTERF3 SLIRP MTPAP FASTKD2 LRPPRC INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 CDC42 RAC1 SRGAP2 SRGAP3 ARHGAP39 SRGAP1 SLIT2 ROBO1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 NPLOC4 POLH RPA3 VCP SPRTN UFD1 UBB DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT GALT SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis TBX6 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 LEF1 PSMD11 PSMD14 PSMD13 PSMA7 CTNNB1 PSMB6 PSMB7 PSMB4 PSMB5 MESP2 DLL3 PSMB2 HES7 PSMB3 MSGN1 RBPJ RIPPLY2 PSMB1 LFNG ADRM1 EPHA4 PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 NOTCH1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F PIK3R1 POLR2G POLR2H NRAS PLCG1 POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 PIK3CA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription CREBBP FLT4 RBPJ MAML2 MAML1 SMAD3 KAT2B HEY1 KAT2A ACTA2 HES1 SNW1 EP300 HEY2 HES5 MAMLD1 MAML3 NOTCH2 NOTCH1 NOTCH4 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RELA MAP3K7 PIK3R2 PIK3R1 NFKB1 CDC34 CHUK IKBKB CARD11 MALT1 NFKBIA UBE2D2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 TRAC PSMA2 INPP5D CD3G TRAT1 CD3E TRAF6 CD3D UBA52 TRBV12-3 PSMD12 TRAV29DV5 PSMD11 TRBV7-9 BCL10 TRBC1 PSMD14 BTRC HLA-DQA2 PSMD13 HLA-DQA1 HLA-DPA1 PSMA7 HLA-DRB5 TRAV19 PSMB6 HLA-DRB4 PSMB7 HLA-DPB1 PSMB4 TRAV8-4 HLA-DRA PSMB5 IKBKG CD4 HLA-DRB3 UBB HLA-DRB1 RIPK2 HLA-DQB2 PSMB2 PIK3CB PSMB3 HLA-DQB1 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 LCK SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 PDPK1 TAB2 PRKCQ PIK3CA UBE2N CUL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription JUN HDAC1 HDAC3 KDM1A MAPK1 MBD3 MAPK3 ATF2 EGR1 GATAD2B GATAD2A RPTOR MLST8 CHD3 SLC38A9 BMI1 CBX6 RING1 HDAC2 MTOR RNF2 RRAGA RRAGC SUZ12 CBX8 PHC2 RHEB RRAGB PHC1 NR2E1 RRAGD CBX4 CHD4 LAMTOR2 CBX2 LAMTOR1 PHC3 SNAI2 LAMTOR4 LAMTOR3 LAMTOR5 MECOM RCOR1 ATN1 EED SALL4 MAF1 HDAC5 MTA2 HDAC7 RBBP4 EZH2 MTA1 REST MTA3 RBBP7 SNAI1 TP53 PPARG CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 RXRA CYCS PTK6 COX5B COX5A STAT3 COX6C HBB HDAC3 SIN3A COX4I1 COX4I2 BLVRB TBL1X COX6A1 BLVRA NCOA1 COX6A2 FABP1 MT-CO1 NLRP3 COX6B2 COX6B1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 HIGD1C ABCC1 ALB HBA2 TXNIP HMOX1 MT-CO2 MT-CO3 HM13 HMOX2 NCOA2 NCOA6 SMARCD3 CARM1 BACH1 HELZ2 CREBBP CHD9 MAFK NFE2L2 MED1 TGS1 STAP2 COX7A2L COX7B COX7C COX8A COX8C PPARA PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNG CHRNE CHRNA6 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions ITGA3 ITGA6 ATP1B3 PPIL2 ATP1B2 ATP1B1 SLC16A8 MMP1 SPN SLC16A3 SLC3A2 SLC7A11 SLC7A10 SLC16A1 MAG PPIA BSG SLC7A5 SLC7A6 ITGB1 SLC7A7 CAV1 L1CAM SLC7A8 SLC7A9 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling TYK2 IL23R STAT4 JAK2 IL12B STAT3 IL23A IL12RB1 P4HB DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage APRT DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PFKFB2 PRKACG PFKFB1 PFKFB4 PRKACA PFKFB3 PPP2R5D PRKACB PPP2R1B PPP2R1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RHOC H2AC20 RHOA RHOB KDM1A PPP1R12B PPP1R14A KLK3 KLK2 KDM4C YWHAB YWHAE MYL9 YWHAQ YWHAG AR YWHAH PKN3 YWHAZ SFN NCOA2 CDC25C PKN2 PKN1 PPP1CB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 PPP1R12A H2AC6 H2AC7 PAK1 RAC1 H2BC17 MYL12B H2BC12 MYL6 H2BC13 MYH9 H2BC14 MYH14 H2AJ MYH11 PDPK1 H2BC15 MYH10 H2BC11 H3C15 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis UBC PGM1 GYG1 RPS27A GBE1 UBA52 GYS1 GYS2 UGP2 GYG2 EPM2A PPP1R3C NHLRC1 UBB APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC16 ANAPC7 UBE2C UBC UBE2E1 UBE2D1 RPS27A ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC20 UBB ANAPC15 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions CACNA1D NCAM1 COL4A2 GFRA1 COL4A1 GFRA2 GFRA4 NRTN CACNA1C CACNA1S PSPN COL6A2 COL4A4 COL6A1 GDNF COL4A3 CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 CNTN2 COL6A6 COL9A2 ST8SIA4 COL6A5 AGRN NCAN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PRNP ARTN GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP5 YWHAZ GP9 RAF1 PIK3R1 VWF FLNA GP1BA GP1BB SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol RXRA ACOX2 ABCB11 NCOA2 AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 ACOT8 BAAT HSD3B7 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall IGHV3-23 IGLV IGLV2-8 SELP IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 SLC16A8 IGKV1D-39 PECAM1 SLC16A3 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SLC16A1 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 APOB IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 IGLC1 PPIL2 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MMP1 IGKV1-33 SLC3A2 IGLC7 SLC7A11 IGHV3-53 SLC7A10 EPCAM IGKV5-2 IGLC6 IGKV1-5 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 SDC1 LYN INPP5D DOK2 GP6 PF4 MIF PPIA CAV1 ITGA3 JAM2 ITGA6 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 OLR1 SPN VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 PSG9 FCAMR PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD ANGPT4 ANGPT2 MERTK CD2 CD244 PLCG1 ITGAM ITGB2 PIK3CB F11R HRAS SIRPG GRB7 PIK3CA ITGB3 ITGB1 L1CAM ITGAV ITGA5 SOS1 TNFRSF10B SHC1 TNFRSF10A PIK3R2 PIK3R1 TNFRSF10D NRAS ITGAX FCER1G ITGAL CEACAM3 CEACAM6 PTPN11 CEACAM8 CD47 TSPAN7 CD44 ITGA4 CD58 PICK1 SIRPA SELL TREM1 PTPN6 CEACAM1 YES1 LCK FYN PROC BSG PROS1 F2 IGHA1 GAS6 IGHA2 JCHAIN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 SOS1 NCK2 SOS2 NCK1 SLIT2 ROBO1 PAK6 PAK1 PAK3 RAC1 PAK5 PAK2 PAK4 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling ACVR2A INHBA INHA TGFBR3 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling PTPN7 PTPN5 IL18R1 PTPN2 PTPN4 SIGIRR SMAD3 STAT3 TBK1 PTPN6 PTPN13 PTPN20 PTPN23 IL18BP CASP1 PTPN18 IL37 PTPN12 PTPN11 PTPN14 PTPN9 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle ERBIN MPP7 VANGL1 ARHGAP32 RHOG ARHGEF5 PIK3R1 ESYT1 ARHGEF26 KALRN ELMO2 MCF2 CDC42 DOCK5 DOCK4 ARHGDIG ANKLE2 DOCK3 ARHGDIA SHMT2 LAMTOR1 NDUFS3 CYFIP1 DOCK2 DOCK1 TFRC PLD1 IQGAP2 STX5 ARHGAP1 HSPE1 ARHGAP39 LETM1 ARHGAP5 ARHGAP35 OPHN1 STBD1 ARHGDIB MAP3K11 EMD LBR TMPO PLEKHG3 VRK2 LEMD3 DEPDC1B ARFGAP3 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO ITSN1 ARHGAP21 PREX1 LMAN1 MCF2L PGRMC2 NDUFA5 VAV3 VAPB KTN1 PAK2 YKT6 ARHGEF16 PAK4 DIAPH3 ITGB1 VAV1 VAV2 CAV1 MCAM REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 SIN3A RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RELA DDX5 NPM1 ITCH VCP NLRP3 ACE2 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 MAVS TKFC RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI PARP10 PARP6 SFTPD GSK3A PARP4 PARP16 YWHAQ PARP9 PYCARD PARP14 YWHAG PARP8 YWHAH UVRAG MAP1LC3B PPIB TRAF3 TRAF6 RB1 BECN1 TLR7 RIPK3 TMPRSS2 RPS4Y2 KPNB1 RPS27L GALNT1 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C HNRNPA1 RPS10 CHMP4B EP300 RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RUNX1 CHMP2B RPS3A RPS26 CHMP2A EEF1A1 RPS25 RPS28 RPS29 PDPK1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PIK3C3 CHMP3 CHMP6 CHMP7 PIK3R4 NFKB1 BST2 PRKCSH GANAB MGAT1 MOGS PCBP2 CANX UBE2I SUMO1 YWHAB FKBP1A ST6GALNAC2 TRIM25 CASP1 IKBKE SIKE1 VHL GSK3B ST6GAL1 SFN YWHAZ UBA52 ST6GALNAC3 ST6GALNAC4 IFIH1 UBB TOMM70 UBC SP1 ST3GAL4 RPS27A BCL2L1 ZCRB1 ST3GAL1 ST3GAL2 ST3GAL3 PPIA IRAK2 PSMC6 KPNA2 CTSL PPIH PPIG CAV1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals DCC UNC5A NTN1 UNC5B SRC UNC5C PTPN11 UNC5D REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBC RPS27A TICAM1 TLR3 TBK1 TRAF3 IKBKE OPTN UBA52 TANK UBB PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy MAP1LC3A VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN TOMM40 UBE2D2 UBE2D3 MTERF3 PINK1 UBE2N VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism FASN PDZD11 SLC5A6 PANK4 VNN1 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP1 ENPP2 ENPP3 SLC25A42 AASDHPPT RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking RAB14 RAB27B TRAPPC4 RAB9A RAB6B RAB9B RAB39A YWHAE MAP1LC3B RAB33B RAB31 RAB5B RAB5C RAB3IP RAB11A RAB6A ARF6 RAB1A TRAPPC1 RAB1B RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 SYTL1 GAPVD1 RIC1 RAB32 RAB35 TBC1D24 RGP1 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB3GAP2 TRAPPC2L DENND6A RAB10 RIN1 TBC1D20 RIN2 RAB3GAP1 GABARAP TBC1D13 RAB18 TBC1D14 TBC1D17 TRAPPC2 TBC1D15 TBC1D16 TRAPPC3 ANKRD27 TBC1D10C DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B TRAPPC8 MON1A MON1B TRAPPC6A DENND1C TRAPPC6B DENND1B GDI1 ULK1 DENND1A RAB8B DENND2D TRAPPC10 DENND2C DENND2B DENND2A RAB3IL1 RAB33A TBC1D2 GDI2 RABEP1 TBC1D3 TBC1D7 RAB7B RABGAP1 DENND3 RAB21 ALS2CL CHML RAB11B RAB12 RAB13 CHM GGA2 GGA1 GGA3 TSC2 TSC1 AKT1 ALS2 RAB3A RAB4A RAB7A OPTN RAB27A RAB8A AKT3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation EOMES FGFR1 SNAI1 TBXT SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2BC9 H2AZ2 H4C9 H2BC8 TBP TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 RRP8 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 H2BC11 H3C15 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters POLRMT TFAM MTERF1 TFB2M G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC RBBP4 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism ENO1 PGK1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal MGMT ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 FBXO5 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis FAR2 AWAT1 AWAT2 FAR1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases YY1 RUVBL1 H2AC20 TGFB1 H2AC1 TGFBR1 TGFBR2 KDM1B INO80C INO80B INO80E INO80D SMAD7 OGT PSMD8 PSMD6 H2AC17 H2AC12 PSMD7 PSMD2 PSMD3 NFRKB SENP8 PSMD1 HCFC1 ACTR5 PSMA5 PSMA6 PSMA3 ACTR8 PSMA4 PSMA1 PSMA2 UBA52 INO80 PSMD12 PSMD11 PSMD14 H2AC25 H2AC21 USP15 PSMD13 BAP1 PSMA7 PSMB6 FOXK2 PSMB7 UCHL1 FOXK1 PSMB4 PSMB5 ACTB UBB TFPT PSMB2 ACTL6A PSMB3 BARD1 UCHL3 UBC H2AC19 PSMB1 UCHL5 H2AC14 RPS27A ASXL1 NEDD8 ADRM1 H2AC8 ASXL2 H2AC6 PSMC5 H2AC7 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MBD5 PSMC2 MBD6 MCRS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling JUN IGF2BP1 MAPK6 MAPK4 KALRN DNAJB1 PRKACG PRKACA PRKACB CDC42 TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B HSPB1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 NCOA3 PSMA2 CDC14A UBA52 PSMD12 PSMD11 CDK1 CCND3 PSMD14 PSMD13 MAPKAPK5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDC42EP5 RPS27A CDC42EP3 CDC42EP2 FOXO1 ADRM1 PSMC5 PAK1 PAK3 PSMC6 RAC1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SEPTIN7 CDC14B FOXO3 PAK2 RAG2 RAG1 ETV4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFB105B DEFA1B DEFB1 DEFB104B DEFA6 DEFB109B DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 CCR6 DEFB133 DEFB132 PRSS3 DEFB108B DEFB108C PRSS2 CCR2 CD4 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC TP53 ARG2 SLC25A2 SIRT5 SLC25A15 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling TAS2R10 TAS2R13 TAS2R14 ADCY9 TAS2R16 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A ITPR1 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP TAS2R38 PDE11A PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 GPR183 PNOC GPR18 SSTR3 PTH1R GPR37 PDE10A GPR31 PTH2R GPHA2 GNAS GPR55 GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 TAS2R42 TAS2R45 CRHR1 PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW TRIO RASGRF2 ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 VAV3 HCAR1 ARHGEF11 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ ARHGEF15 PLEKHG5 HEBP1 ARHGEF17 GRM3 ARHGEF16 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A AGT GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP APP F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 RGSL1 GRPR CYSLTR1 CCL1 EDNRA CCL19 EDNRB PROK2 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 GPR17 ACKR3 NMB CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK ADORA1 HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HBEGF HRH2 HRH4 DRD1 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA PAK1 C3 ROCK1 ROCK2 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology NR5A1 CLTB YAP1 RELA WNT1 PERP ARPC1B ARPC1A ARPC4 ARPC5 MAMLD1 SLC2A2 ARPC2 ARPC3 IHH ACTR3 ACTR2 CNOT10 CNOT11 TCF3 YWHAE LDB1 LEP DPY30 CHD4 YWHAG CSF1 YWHAH EED MTA2 CARM1 DAG1 MMP2 MAML2 MAML1 TRIO ITSN1 MED1 RAC1 MED8 VAV3 ARHGEF11 MED4 ARHGEF12 MED6 MED7 PRKCQ MAML3 CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 NKX2-5 ARHGEF7 SOS2 NGEF KALRN RET RARG ASH2L TFAP2A TFAP2B TFAP2C UBE2I TNKS1BP1 SUMO1 TEAD1 TEAD2 TEAD4 HIF3A ELOB TCF12 ELOC RBX1 RARB AJUBA EPAS1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C POLR2A PLXNA3 POLR2B LCE1A POLR2C LCE1B POLR2D LIPJ POLR2E LIPN POLR2F LIPM POLR2G PRSS8 POLR2H LIPK POLR2I POLR2J KRT4 POLR2K KRT3 POLR2L KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ACTB LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL CSNK2A1 KRT33B KRTAP5-10 KRT33A CSNK2A2 KRTAP5-11 SPRR2A SPRR2B SPRR2D CSNK2B ST14 CDSN KRTAP16-1 KRTAP8-1 TP53 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 SOX17 KRT27 SRY KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 ABL1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 PLAC8 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A PLXNA4 MAP2K6 KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B CNOT4 KRTAP2-4 CDK8 KRTAP2-3 KRTAP2-2 CNOT6 KRTAP2-1 CNOT7 KRT13 KLK13 CDK5 CNOT1 KRT12 KLK14 CNOT2 CNOT3 KRT10 LCE3E KLK12 KRT19 CNOT8 KRT18 KRT17 CNOT9 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 WDR5 KRT6C KRT6B RPTN ZNF521 KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 KRT76 SMARCD1 KRT75 SMARCD2 KRT74 SMARCD3 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 RBBP4 KRTAP23-1 RBBP5 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PTPRC LELP1 RBBP7 KRTAP4-1 ACTG1 KRTAP12-1 KRTAP12-3 KRTAP12-2 SMARCE1 KRTAP4-9 KRTAP4-8 KRTAP12-4 KLF4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 PFN1 KRTAP11-1 CELA2A SOX2 PFN2 KRTAP5-9 KRTAP5-8 KRTAP5-7 NFASC KRTAP5-6 KRTAP5-5 KRTAP5-4 SOX9 KRTAP19-2 KRTAP19-1 RUNX3 SRGAP2 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DIAPH1 DSG4 RPS27 KRT82 KRT81 ITGB1 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 RHOC KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 RHOA KRTAP6-3 RHOB KRTAP21-1 EVL SRF CDK5R1 CDC42 COX7A1 CLASP1 CLASP2 KDM5B ARID1A ARID1B TYROBP IFNG ERBB2 HES1 POMC MARK3 MMP9 NCBP1 NRP2 NCBP2 TLN1 CNTN2 NRCAM ANK1 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 FYN POU3F3 WNT4 MCM5 MCM2 CLTC CYP51A1 SREBF2 CLTA AP2A1 VLDLR AP2A2 CDON AP2M1 PBX1 RAP1GAP PRKACG PRKACA PRKACB CCL3 ANGPTL4 LPL AP2S1 CXCL12 DICER1 AP2B1 TRPM1 PAX3 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP LAMA5 LAMA2 SH3KBP1 PXN LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NUMB UCP1 MTA1 PRDM16 ZNF423 ENAH MTA3 RPS4Y2 EBF2 RPS27L BMP7 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 GMPR RPS3 MYO10 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 PPP3CB RPS25 MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 WNT11 NOTCH1 CACNA1D GCK NFATC1 NANOG HSP90AB1 RDX NAB1 NAB2 DNM2 SIAH1 EGR2 EPRS1 ID1 EIF4E ID4 EIF4B ZFPM2 EPHB6 EFNB2 ARHGAP39 EFNB1 EFNB3 EPHB2 EPHB1 ARHGAP35 EPHB4 EPHB3 ITGA10 FOXH1 ACVR1B WNT3A ACVR2B GIT1 ACVR2A DRAP1 ACVR1C DSG2 EPHA2 PAK1 ABL2 PAK2 PAK4 POU5F1 TGFB1 CNTN1 FOXC2 FOXC1 SIX1 HOXD11 NPNT HOXC11 HIRA PAX2 HOXA11 GREM1 SALL1 SIX2 DSCAM DCC DSCAML1 NTN1 STX1B TNFSF11 SRGAP3 SRGAP1 JUP FGFR1 WASL IAPP PAK6 PAK3 PAK5 MYO9B TPST2 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 SERPINE1 RPL4 RPL5 RPL30 RPL3 ITGA2 RPL32 RPL31 RPLP1 ITGA8 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 CTCF RPLP2 FABP4 HOXA3 RPL35 COL9A1 RPL38 HOXA1 PKNOX1 COL9A3 RPL37 PRL COL9A2 HOXA4 AGRN PIAS2 RPL39 RPL21 HOXB4 CHD3 RPL23 HOXB3 RPL22 HOXB2 HOXB1 RPL13A HOXD1 RPL9P9 HOXC4 RPL37A RPL24 MEIS1 RPL27 MAFB RPL26 HOXD4 HDAC2 DPF1 RPL29 HOXD3 RPL28 ZNF335 DPF2 RPL10 RPL12 DPF3 RPL11 RPL36A SUZ12 RPL14 PAXIP1 RPL13 RPL15 RPL18 RPL17 RPL19 PCGF2 RPL39L SS18L1 RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 CD36 NCOA2 SS18 NCOA6 NCOA3 TET3 SHH DHH ADIPOQ CREBBP EYA1 BCL2 NTN3 AREG CDH4 BNIP2 TNF CTNNA2 MYOG EBF1 WNT10B SPAG9 MEF2B NR2F2 MYOD1 ADIRF PAGR1 MYF6 SLC2A4 ZNF638 TCF4 BCL7A CEBPD CDH15 ZNF467 BCL7C MYF5 BCL7B FOXA1 KDM6A TGFA FOXO3 ABLIM1 ABLIM2 PTK2 ABLIM3 AKT3 JUN MED19 UHRF1 MED18 MED11 MED9 MED29 MED28 MED22 MED21 CDK19 MED13L ETF1 GSPT2 GSPT1 ASAH1 GSC MIXL1 UPF3A UPF2 UNC5A UNC5B CIDEA CAP2 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 MC4R DARS1 EEF1E1 MC3R KARS1 IARS1 PKP1 MC5R SDCBP DSP DSG1 DSG3 MAPK7 APH1A ZIC1 FOXD3 PSENEN NCSTN TFE3 APH1B MITF CLTCL1 PSEN2 TFEC ADAM10 ALX3 TBX3 PSEN1 DNM1 SDC2 STT3B GPC1 MAG PRDM14 CRIPTO SHC3 LIN28A ZIC3 ZSCAN10 DNM3 MAPK12 GATA3 LYN SIAH2 RPLP0 PITPNA CFL1 STAT4 IL12RB2 ACTL6A MSN PIK3CD KAT2B KAT2A MEF2A FGF8 RPS6KA3 SOX1 GBX2 RPS6KA5 RPS6KA2 OTX2 TBX6 RPS6KA1 POU3F1 YY1 ITGA1 LEFTY1 CRIPTO3 ONECUT3 DAND5 ONECUT1 CFC1 CER1 PDX1 NKX6-1 NODAL PTF1A PAX6 ISL1 PTGDS FOXO4 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD1 SMAD4 SMAD3 NEUROG3 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 USP33 SNAI2 FOXA2 NEUROD1 NKX2-2 PAX4 HNF1A MAFA RFX6 INSM1 FOXA3 FARP2 PLXND1 PKP4 PLXNA1 IRS2 PIK3CB PLXNB1 FGF2 NCK2 FGF4 NCK1 FGF7 MESP1 FGF9 AKT2 GATA6 TBXT GRB10 ATP6V1E1 TBX20 SMYD1 TBX1 EOMES HRAS ATP6V1G1 MYOCD HAND1 ATP6V0B ATP6V0E1 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 HNRNPU SPTBN1 ATP6V0D1 SOS1 ATP6V0C MAGOH ATP6V1A SHC1 PIK3R2 PIK3R1 INS NRAS ATP6V1H MAPK1 ATP6V1C1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 FGF10 UPF3B MAGOHB SNW1 SRC RNPS1 SHANK3 GRIN2B THRAP3 GRIN1 RND1 DLG1 DLG3 TBPL2 DLG4 MBP EMX2 FAM120B ADGRV1 PCDH19 DOCK1 WFDC2 MECOM MSX1 MPZ OSR1 PLK1 ADGRG6 ZIC2 HMGCR TBX21 SALL4 CCNB1 HOXA6 PAX8 PAX7 AMH GDF1 PRX NOG CTNNA1 DMRT1 NOTO PMP22 FOXF1 SOX10 BRCA1 ZEB2 CASC3 SNAI1 RANBP9 KAT5 GXYLT2 CDH2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP CEACAM1 ZEB1 DCT IRF4 SEM1 PXDN BIRC7 BCL2A1 TYRP1 MLANA USF1 MLPH RBM8A CXCR4 EDNRB KIF4B KIF4A CAP1 EDN1 EDN3 LEFTY2 PABPN1 PI3 CAPNS1 CAPN1 SCD5 ELOVL3 KIT BMP4 TCF7L2 CDKN1A ALCAM TCF7L1 SCN11A HDAC1 HOXA2 CDKN2A UNC5C LEF1 UNC5D TCF7 CDC25B SCN10A AGAP2 TBX2 FLRT3 HINT1 CCND1 CHL1 LYPLA2 SIN3A ZSWIM8 CDK2 MSI1 CTNNB1 COL6A2 MET PLXNC1 SEMA6A COL4A4 SEMA6D CEBPB SEMA7A COL6A1 GPR143 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 LHX4 COL6A3 LHX9 RBPJ CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB TNRC6C COL6A5 MOV10 NTN4 STX1A SEMA3E MEF2C AGO3 SEMA4A AGO4 NELL2 CDH1 RPS6KA4 SCN1B MYC AGO1 SCN1A AGO2 EPHA5 EPHA4 TNRC6A EPHA7 TNRC6B EPHA6 YWHAB EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 XPO1 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B AKT1 SCN3A PSMD1 PRNP SPTBN2 GATA4 ARTN CD24 SCN2A SCN2B PRKCA ROBO2 YWHAZ GFRA1 PSMA5 GFRA3 PPARGC1A PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 RGMA PPARGC1B PSMA1 GFRA4 RELN PSMA2 CD72 SCN9A PABPC1 NRTN DOK2 UBA52 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C EFNA5 PSMD13 EFNA4 SPTA1 EZH2 PSMA7 CACNA1S PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX MED16 PSMB2 SCN4A MED15 PSMB3 SCN4B MED17 SLIT1 SCN7A UBC MED12 PSMB1 SLIT3 MED14 PDLIM7 MED13 RPS27A HEY1 MED10 HSPA8 HEY2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 CACNA1H PSMC2 MYL12A MED27 SIRT1 CACNA1G MED26 CACNA1I EIF4G1 MED23 MED25 MED24 MED20 PPARG PPARA DRP2 FURIN PCSK6 ROCK1 ROCK2 UTRN MBD3 GATAD2B GATAD2A NCAN RPS6KA6 HSP90AA1 EGF EGFR PLCG1 CCND3 E2F1 TFDP1 TFDP2 CDK4 KMT2D H2AX CSF3R SPI1 GFI1 LIG1 H2AB1 DLX5 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 FOXO1 DOK1 MYB EP300 IL6R RASA1 H3-3B H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 BTG4 RUNX1 EIF4A2 H2BC12 H2BC13 KDM5A EIF4A1 H2BC14 TUT7 H2AJ TUT4 H2BC15 DUX4 TAL1 H2BC11 PABPN1L RARA TPRXL DUXA CEBPA KMT2A DUXB DIS3L2 CBFB CEBPE KDM6B GATA2 PRM2 H3C15 PRM1 RXRA STPG4 H2BC9 METTL23 H2AZ2 DPPA4 DPPA3 H4C9 H2BC8 DPPA2 H2BC5 ZFP36L2 H2BC3 LEUTX STAT3 PAIP1 NPM2 H2BC1 NFKB1 KDM4E DEK FLI1 TPRX1 AICDA KLF5 H2AC20 SRPK1 H1-8 TPRX2 HDAC3 ZSCAN4 TBL1X PCK1 NCOA1 NCOR2 NCOR1 HAND2 TBL1XR1 SLIT2 PLIN1 ROBO1 SEMA5A AKAP5 TBX5 CACNG8 CACNG2 CACNG3 CACNG4 TRIM33 SMARCB1 CCNC SMARCC1 SMARCC2 HELZ2 CHD9 ST8SIA4 TFEB SH3GL2 WWTR1 YES1 TGS1 MEF2D SMARCA2 SMARCA4 ST8SIA2 HNF4G DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 MAN1B1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR SOS1 HBEGF SHC1 ARHGEF7 PIK3R1 NRAS STAM2 ADAM10 ADAM12 PTPRK EPS15L1 EPN1 PTPN11 SPRY1 PTPN3 CDC42 FAM83B ADAM17 SRC LRIG1 SH3KBP1 PXN EGF CBL EGFR UBA52 PLCG1 STAM CSK HGS PTPN12 UBB PAG1 UBC RPS27A FAM83D SH3GL3 AREG FAM83A EPS15 SH3GL2 SH3GL1 AAMP SPRY2 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV GYG2 GBE1 GYS2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication ORC4 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 CCNB1 RB1 CDK1 PPP2R3B E2F1 MCM8 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B ORC5 POLA2 PPP2R1A NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway RXRA NR5A1 NR2C2 PPARD NR2C1 NR2C2AP RXRG NR2F1 NR0B2 NR2F6 NR1D2 RXRB NR1D1 ESRRA RARG ESRRB ESRRG NR1H2 NCOR2 NCOR1 ESR1 VDR ESR2 HNF4A MED1 NR4A2 NR4A1 RORC THRB RORA THRA RORB NRBP1 HNF4G NR2E1 RARB RARA PGR PPARG AR PPARA RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME SLC29A1 ADK SLC29A3 NME1 NT5C2 SLC28A3 NME2 PNP ITPA ADA SLC28A2 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PLD6 PLD2 PLD1 PLD3 PGS1 CDS2 PTPMT1 PLD4 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle FAM169A ADD3 AKAP12 SNAP23 VANGL1 ARHGAP1 ARHGAP32 SLC4A7 ARHGAP39 PIK3R2 ARHGAP5 PIK3R1 RHOF ESYT1 SYDE1 BAIAP2L1 ACTN1 POTEE LMNB1 TMPO BASP1 ACTB TOR1AIP1 ARHGAP12 DEPDC1B CAPZB VAMP3 RAB7A STEAP3 DIAPH2 ARHGAP21 SOWAHC FARP1 MYO9B SRGAP2 MTMR1 BAIAP2L2 SENP1 DIAPH1 DIAPH3 CAV1 MCAM DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology ASH2L NCOR2 NCOR1 TBL1XR1 HDAC1 HDAC3 CAMK4 GPS2 SIN3A RBBP5 PRKACA DPY30 TBL1X WDR5 CALM1 KMT2D IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly UQCRFS1 BCS1L UQCRH LETM1 TTC19 UQCRHL FXN LYRM4 HSCB LYRM7 UQCRC1 UQCRC2 UQCC3 UQCC2 UQCC1 CYC1 UQCC6 UQCC5 UQCR11 UQCR10 UQCRQ HSPA9 UQCRB MT-CYB RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 RRN3 CBX3 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 MBD4 MPG SMUG1 OGG1 NTHL1 APEX1 TDG REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 HEYL SPCS3 SPCS2 SPCS1 ANGPTL4 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRDM8 CTNND1 UBA52 BHLHE22 CDH8 PSMD12 ZC3H12A PSMD11 CTNNA1 PSMD14 CDH24 HOXC8 PSMD13 FOXF1 CSNK2A3 ADAM33 SOX10 EZH2 PCSK7 PSMA7 ADAM19 ILF3 PSMB6 MPHOSPH8 ZEB2 CDH11 PSMB7 SNAI1 CDH19 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity NR3C1 ESRRA STAT1 NKX3-2 MSX2 ESR1 SMURF1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B PSMA5 STUB1 PSMA6 PPARGC1A PSMA3 PSMA4 PSMA1 PPARGC1B PSMA2 UBA52 PSMD12 PSMD11 PSMD14 WWP1 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DLX5 PSMB1 DLX6 RPS27A HIVEP3 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TWIST1 CBFB CUL1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT GPAA1 PLAUR PIGK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 TPMT MTR AS3MT MAT1A NNMT MTRR COMT CYP1A2 MAT2B HEMK2 MAT2A GSTO1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle APBA1 SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 CASK LIN7A LIN7C LIN7B TSPOAP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L POLRMT GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB AJUBA ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ACTB ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ANG AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 PSIP1 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 GTF3C1 ARID1A GTF3C2 ARID1B GTF3C3 RBL2 GTF3C4 RBL1 CRCP IFNG GTF3C5 ZNF197 GTF3C6 ZNF195 BRF1 NR2C2 POLR3GL NR2C1 POLR3A THBS1 POLR3B HSPD1 VEGFA POLR3C ERBB2 POLR3D HES1 GLS2 POLR3E ZNF189 POLR3F ZNF286A POLR3G ZNF184 POLR3H ZNF180 BDP1 OPRK1 GLS POLR3K ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 BCDIN3D CDK9 TCEA1 XPO5 DROSHA JAG1 MTERF1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ANGPTL4 LPL TSNAX PRKRA DICER1 TARBP2 TSN SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A TRPC3 MTA1 MTA3 ELAC2 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAN LBR CAV1 TGFB1 STEAP3 ITGA2B TDG ITGA5 SERPINE1 LIPE DGAT2 FABP4 CHD3 BMI1 LPIN1 SUMO2 MGLL RING1 RRP8 HDAC4 SAP130 HDAC2 DPF1 L3MBTL2 PDK4 DPF2 SATB2 KAT8 RNF2 DPF3 SAP30BP HCFC2 SUZ12 WDR82 CBX8 PAXIP1 PHC2 PEX11A PHC1 BAZ2A CBX5 KAT14 CBX4 PCGF2 SETDB1 SS18L1 CBX2 SMARCA5 PHC3 ZZZ3 GSK3B TADA2A ZNF816 EZH1 AXIN1 PHF1 SUV39H1 GPI SGF29 CD36 CDC73 JARID2 NCOA2 SS18 NCOA6 NCOA3 TET2 SKIC8 TET1 PPHLN1 BAZ1B PHF20L1 CTR9 RTF1 NR5A2 AEBP2 MTF2 TET3 LEO1 PLIN4 PAF1 PLIN2 MBD2 MYBBP1A MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 SP1 TASOR MBIP TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C BCL7B CAMK4 DNMT3B UBTF BDNF ZNF765 KDM6A TGFA DNMT3A FOS POLR1A FOXO3 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H AKT3 C19orf84 JUN ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP ERCC6 RRN3 CIDEC HCFC1 AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X MCRS1 YY1 USP7 NFIX SSB USP2 NFIA NFIB NFIC FOXO4 ATXN3 SUDS3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 TADA3 MDM2 MDM4 OGT PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 TFAM TFB2M CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP PLD6 MAPK1 CAVIN1 CSTF3 CSTF2 DDX4 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S SF3B1 CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 IPO8 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 MTREX RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 PIWIL2 TDRKH SNRPB SRSF9 PIWIL1 HENMT1 RBM8A ASZ1 MAEL MOV10L1 MYBL1 CPSF4 TDRD9 CHTOP TDRD6 TDRD1 TDRD12 CPSF1 FKBP6 ALYREF CPSF3 CPSF2 YBX1 RBM7 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SAP18 MORC2 GTF2A1 GTF2A2 GTF2B ACSL1 ELOVL5 GTF2E1 GTF2E2 KIT SCD TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 HSP90AA1 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 CEBPA KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L NCOA1 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 PLIN1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 PCBP4 TP53 CDKN1A ZNF385A MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation MT-ND6 COX5B MRPS10 COX5A MT-ND5 MT-ND2 MRPL32 MT-ND1 ECI1 PCCB SUCLG2 UQCRC2 PRKACA MRPS2 OGDH MT-ATP6 STAR FH SHMT2 TRIAP1 ATP5PF ATP5PD MRPL12 MDH2 ATP5F1C ATP5PO NDUFA13 SLC25A5 SLC25A6 HSD17B10 SPG7 AFG3L2 SMDT1 YME1L1 PMPCA NDUFV3 ATP5MG MICU2 NDUFV1 STARD7 IDH2 UQCRQ TFAM HADH OMA1 OPA1 ALDH1B1 ME2 IDH3A BDH1 OXCT1 HMGCS2 PRELID1 ACAT1 NDUFS1 CHCHD2 NDUFB6 COX4I1 IARS2 ARG2 MT-CO1 HTRA2 ECH1 ACOT2 NDUFA2 LONP1 TWNK SSBP1 LDHD MT-CO2 NDUFS3 CS HSPD1 ACO2 PDHB GLUD1 TIMM17A PDK1 PDHA1 TIMM22 HSPA9 OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 ALAS1 TIMM9 TIMM10 ATP5F1A ALDH2 ATP5F1B DBT DLD PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy SQSTM1 UBC MAP1LC3B PEX5 NBR1 RPS27A ATM EPAS1 UBA52 USP30 UBB RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 NFKB1 NFKBIA DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP62 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 CDK1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C CCT2 TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBB6 TUBB3 CCT7 TUBB1 TUBA3D TUBA3C CCT8 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PXN TESK1 PARVA PARVB ARHGEF6 RSU1 LIMS1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 HBEGF EGF ERBB2 EGFR NRAS NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi CHST8 B4GALT4 CGA FUT8 MAN2A1 MGAT5 MGAT2 FUCA1 MGAT3 MGAT4C CHST10 B4GALT6 B4GALT5 MAN2A2 ST3GAL4 MGAT4A LHB MGAT4B B4GALT1 ST8SIA6 FUT3 ST8SIA2 B4GALT2 B4GALT3 ST8SIA3 ST6GAL1 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism MTMR3 MTMR8 MTMR9 PIK3R4 RAB14 PIK3R2 MTMR6 PIK3R1 MTMR7 PITPNB INPP5E PIP5K1A PIP5K1B GDE1 SACM1L ARF3 MTMR14 VAC14 PI4KA PI4K2B MTMR10 MTMR2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A FIG4 PIP4P1 INPP4B INPP5J INPP5K PIKFYVE INPP5F PI4K2A PTEN MTMR1 PIP5K1C TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 GDPD1 RAB4A GDPD3 GDPD5 RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PNPLA7 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 PNPLA6 INPPL1 RUFY1 TPTE ENPP6 SBF1 PIK3CA PIK3R3 SBF2 TPTE2 PIK3C3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated APC MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle SLC25A11 MDH1 GOT1 MDH2 SLC25A12 SLC25A18 GOT2 SLC25A13 SLC25A22 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX9 MYD88 NFKB2 RELA NFKB1 IRF7 DHX36 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation RPS2 METTL21A KIN METTL22 HSPA8 EEF2KMT VCPKMT ETFBKMT EEF1AKMT2 EEF1AKMT1 EEF2 EEF1A1 CAMKMT VCP PRMT3 CALM1 ETFB TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 SLBP NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass PCNA UBA52 NPLOC4 POLH WDR48 USP10 RAD18 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL UBA7 RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2L6 TRIM25 UBE2B POLE2 POLE3 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KCNK12 KCNK15 FXYD4 FXYD3 FXYD2 DMPK FXYD1 FXYD7 FXYD6 MME ATP2B4 NPR1 RYR1 ATP2B3 NPR2 RYR2 ATP2B2 NPPC RYR3 ATP2B1 TRPC1 CORIN CES1 SLC8A3 CLIC2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 ATP1A4 CACNG6 ATP1A3 CACNG7 ATP1A2 TNNI3 ATP1A1 KCNIP1 KCNIP2 KCNIP4 KCNK6 RANGRF KCNK7 PLN KCNK1 KCNIP3 FKBP1B CACNA2D2 CACNB2 NKX2-5 SCN11A SCN10A CACNB1 SCN1B CAMK2B SCN1A CAMK2D CAMK2A KCNH2 TBX5 SCN3B SCN3A KCNK10 CACNG8 GATA4 CALM1 KCNK13 SCN2A CAMK2G KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 CACNG4 KCNJ2 KCNJ4 SCN9A KCNK9 SCN8A KCNJ12 CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A SCN4A KCNA5 SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 WWTR1 AHCYL1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors GPR31 FFAR4 FFAR1 FFAR3 FFAR2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PI4KB PIK3C2A PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2A ARF1 INPP5E TPTE SACM1L ARF3 OCRL TPTE2 PIK3C3 VAC14 PI4KA INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins KCNQ2 KCNQ3 SCN9A SCN11A SCN10A SCN8A SPTAN1 SPTA1 SCN5A SCN4A SCN4B SCN7A NRCAM SPTB ANK1 SCN1B SCN1A NFASC ANK2 ANK3 SPTBN4 SPTBN5 SCN3B SCN3A SPTBN2 SPTBN1 L1CAM SCN2A SCN2B CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 ERBIN HRAS SOS1 HSP90AA1 SHC1 ERBB2 CDC37 NRAS PTPN12 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN NCSTN APH1B PSEN2 PSEN1 YBX1 NOTCH3 APH1A ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage MAPDA GMPR2 ADK AMPD1 TK1 GMPR AMPD2 CDA AMPD3 DCK APRT DGUOK PNP HPRT1 ADA UCKL1 UCK2 UCK1 PUDP TK2 UPP2 UPP1 TYMP TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC26A2 SLC22A5 ABCB6 SLC24A2 ABCB4 SLC24A3 KCNJ11 SLC41A2 SEL1L SLC5A1 SLC41A1 SLC5A2 SLC30A10 ABCC9 ADCY9 SLC39A6 SLCO1B1 SLC39A5 SLCO1B3 ERLIN1 ADCY4 SLC39A8 ERLIN2 ADCY3 SLC39A7 CP ADCY2 SLC39A2 SLC6A5 ADCY1 SLC39A1 ADCY8 SLC39A3 SLC2A9 ADCY7 SLC26A4 SLC30A8 ADCY6 RNF185 SLC30A3 ADCY5 SLC26A3 SLC30A2 SLC31A1 SLC30A5 SLC40A1 SLC39A10 SLC2A1 ATP2A3 SLC30A1 SLC2A2 ATP2A2 SLC6A2 SLC39A14 ATP2A1 SLC6A3 SLC8B1 SLC8A1 SLC8A2 SLC22A12 HEPH ABCC2 SLC2A10 ABCC6 AVPR2 SLC24A4 SLC16A7 DERL3 SLC16A8 DERL1 EMB DERL2 SLC16A3 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 RHAG SLC24A5 APOB ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 GNAS RAB11A SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 NEDD4L ADD1 TUSC3 MAGT1 ZDHHC8 SLC46A1 SLC5A5 VDAC3 VDAC2 VDAC1 CFTR SLC32A1 SLC6A13 SLC6A1 ARF1 WWP1 CYB5R2 CYB5R4 CYB5RL SLCO1A2 NEDD8 ARL2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 VCP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SLCO4C1 HMOX2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 LETM1 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC6A7 ATP6V0B PLEKHA8 ATP6V0E1 ATP6V1G2 ATP6AP1 SLC6A11 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ABCG2 ATP6V0A2 SGK1 HBB ATP6V1H SLC6A4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 SLC17A7 ABCA3 ABCC3 CAMK2B ABCC1 CAMK2D ABCD3 CAMK2A SLC2A3 CALM1 CAMK2G ADD3 SLC4A7 PHB1 SLC25A10 CAND1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SEM1 SLC4A2 SLC4A3 SLC4A5 SLC5A8 SKP1 SLC5A9 TFR2 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A12 NIPA1 CUL1 NIPA2 CLTC SLCO4A1 SLC17A1 HDLBP RHBG PCSK9 CLTA DMTN SLCO2B1 AP2A1 SLC26A11 VLDLR LIPA SLC16A2 RHCG AP2A2 LIPC SLC26A1 CREB3L3 SLC15A1 IREB2 LIPG SLC14A1 CTNS LDLRAP1 SLC15A3 SLC14A2 AP2M1 SLC15A4 SLC4A10 CUBN CYBRD1 CYB5R1 PIP AMN SLC26A7 APOA2 ACO1 APOA1 SLC26A9 LSR SLC26A6 APOA4 PRKACG SLC25A1 APOA5 MB NPC1 RAF1 PRKACA SLC13A1 SOAT1 PRKACB SLC13A2 SOAT2 SLC13A3 NPC2 ANGPTL8 ATP7A SLC13A4 ANGPTL4 NGB SLCO1C1 LPA SLC47A2 CES3 TF CA1 SAR1B SLC47A1 SLC5A12 MTTP SLC5A10 LPL CA2 LMF2 SLC25A26 LMF1 LRRC8C CA4 LRRC8D APOF AP2S1 LRRC8A LRRC8B A2M LDLR SLC13A5 SLC11A1 GPIHBP1 LRRC8E GLTP FGF21 RSC1A1 MBTPS1 APOBR AHCYL2 APOC3 NIPAL4 NIPAL1 AP2B1 NIPAL2 TRPM1 NCEH1 ALB NIPAL3 TRPM2 P4HB AZGP1 TRPM7 SLC22A4 TRPM8 MBTPS2 SLC22A3 TRPM5 SLC22A6 TRPM6 SLC45A3 TRPM3 ANKH TRPM4 TRPC7 RAB11FIP2 ABCC4 TRPC5 SLC10A6 MCOLN3 MYO5B TRPC6 MRS2 AQP12A TRPA1 SLC22A15 AQP10 TRPC3 AQP8 SLC22A16 TRPC4 AQP9 SLC22A17 TRPC1 AQP6 SLC22A11 AQP7 SLC20A1 TRPV2 AQP4 SLC66A1 TRPV3 AQP5 FTMT TRPV1 MCOLN1 AQP2 ESYT3 MCOLN2 AQP3 ESYT2 AQP1 STEAP4 TRPC4AP MIP HFE TRPV6 MMGT1 TRPV4 AQP11 TRPV5 SLC2A6 SLC2A7 SLC2A8 PDZD11 GLRX3 CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 SLC35B3 LCN9 SLC35B2 STOML2 SLC27A1 MCUB LCN2 SLC35B4 SPG7 PHB2 SLC35D1 MAIP1 SLC35D2 LCN15 PARL AFG3L2 LCN12 SMDT1 SLC35A2 YME1L1 SLC35A3 PMPCB SLC33A1 SLC5A6 PMPCA ARL2BP MICU3 LCN1 MICU2 SLC29A4 MICU1 PRKAR1B SLC27A6 MCU PRKAR2B SLC28A2 PRKAR1A SLC29A1 PRKAR2A SLC2A13 SLC28A1 SLC29A3 SLC5A11 SLC5A3 SLC29A2 SLC28A3 SLC27A4 CYGB EIF2S2 EIF2S1 EIF2S3 PSMD8 PSMD6 HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 TFRC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 ABCA6 ABCD2 UBA52 AKAP1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 SLC6A9 PSMB7 SLC17A6 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 UBC ABCC5 PEX3 ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 SLC1A5 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 PEX19 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 FURIN BEST3 PCSK6 SLC9C2 BEST1 PCSK5 BEST4 ESYT1 SLN ATP11C SLC67A1 ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 STEAP3 ATP8B1 ATP4B ATP4A FXYD4 FXYD3 WNK1 FXYD2 WNK2 FXYD1 HBA2 WNK3 FXYD7 FXYD6 CUTC RYR1 RYR2 RYR3 UNC80 ATP7B CLIC2 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 SLC22A7 STOM SLC12A2 SLC12A4 RUNX1 SLC12A5 SLC12A7 FTH1 FTL SLC25A18 CETP SLC25A11 APOD APOE ABCA1 ABCG8 MYLIP SLC25A22 ABCG5 NR1H2 APOC4 NR1H3 APOC2 APOC1 ANGPTL3 ABCG1 SLC35C1 SLC24A1 SLC17A5 AVP SLC2A4 SLC35A1 SLC22A8 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling CREBBP RELA ICAM2 LYN ICAM3 RELB NFKB1 EP300 NRAS PAK1 PAK3 HRAS FYN PRKACG RAF1 PRKACA PRKACB PAK2 CD209 RPS6KA5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B RAD50 RAD51D BLM RAD51 MRE11 RAD51C BRCA1 BRCA2 RAD51AP1 WRN ATM BRIP1 DNA2 KAT5 EXO1 RBBP8 NBN MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DBT DLD VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 PCNA CDC6 HDAC1 DYRK1A CDK1 CDC25A E2F1 RBBP4 CDK2 TFDP1 CCNE2 TFDP2 LIN54 TOP2A LIN37 CCNE1 LIN9 MAX LIN52 MYC E2F4 E2F5 CCNA2 CCNA1 MYBL2 RBL2 RBL1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO6 FOXO3 FOXO1 RPS6KB2 AKT1 AKT2 FOXO4 NR4A1 AKT3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis RXRA SCD NR1H2 FASN NR1H3 RXRB NRIP1 ANGPTL3 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 HSP90B1 DDIT3 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25A PKMYT1 WEE1 CLSPN YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 CDC25C ABRAXAS1 TP53BP1 H2AX H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDC7 CDK2 CDC45 MDC1 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SFN YWHAZ PSMA5 PIAS4 PSMA6 PSMA3 PSMA4 BRCC3 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 BLM MRE11 PSMA7 BRCA1 BABAM1 PSMB6 BABAM2 PSMB7 WRN BRIP1 KAT5 PSMB4 EXO1 UIMC1 CHEK1 PSMB5 RBBP8 NBN UBB TOPBP1 PSMB2 ATRIP PSMB3 BARD1 UBC RFC5 RMI2 PSMB1 RFC3 GTSE1 RFC4 RPS27A RMI1 RFC2 TOP3A ADRM1 RPA1 HUS1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 RAD50 PSMC4 PSMC1 MCM7 PSMC2 MCM8 RPA3 RAD17 TP53 CCNB2 CCNA2 RAD1 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 ORC5 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription REST SRF NR3C1 KCNIP3 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling MET GAB1 PIK3R1 HGF PIK3CA G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint WEE1 CCNA2 CCNB2 CCNA1 CCNB1 CDK1 PKMYT1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells RELA MAP3K7 NFKB1 CHUK IKBKB CARD11 MALT1 NFKBIA PSMD8 PSMD6 PSMD7 PSMD2 REL NFKBIE PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PSMC5 PSMC6 PRKCB SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 RAB11FIP3 RAB8A ARF4 GBF1 PKD2 RAB3IP PKD1 RAB11A RHO CNGA2 CNGA4 EXOC8 EXOC7 CNGB1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG MTR MTRR INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 FZD2 APC FZD5 PPP2R5B WNT1 PPP2R5A FZD1 PPP2R5D PPP2R5C CSNK1G2 WNT3A LRP5 CTNNB1 LRP6 WNT8A WNT8B PPP2R1B PPP2R1A PPP2CA PPP2CB DVL1 DVL2 DVL3 AMER1 GSK3B CSNK1A1 CAV1 FRAT1 PPP2R5E AXIN1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT DHRS7B AGPS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins MUC13 B3GNT3 B3GNT5 B4GALT6 B4GALT5 GALNT12 ST6GALNAC2 C1GALT1C1 MUC12 ST6GAL1 MUC15 MUCL1 MUC3A MUC5AC MUC3B GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ST6GALNAC3 GALNT10 GALNT9 ST6GALNAC4 MUC1 GALNT8 MUC2 B3GNT9 QTGAL B3GNT8 B3GNT6 MUC7 GALNT1 CHST4 MUC4 GCNT1 MUC6 GCNT3 MUC16 GCNT4 GALNT3 GCNT7 MUC17 GALNT7 C1GALT1 GALNT6 MUC19 GALNT5 ST3GAL4 GALNT4 MUC5B A4GNT MUC20 GALNTL5 MUC21 GALNT2 GALNTL6 ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT4 B3GNT2 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL WDR83 SRC YWHAB HRAS IL17RD ARRB1 ARRB2 LAMTOR2 MAP2K1 MAP2K2 ITGB3 LAMTOR3 ITGA2B RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell DISP2 SCUBE2 SHH IHH DHH ADAM17 NOTUM GPC5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance KIFAP3 APOOL PRKACA KIF3B KIF3C ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 YWHAE CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 YWHAG RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 RAB11A ATAT1 TTC8 SOD2 CARM1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 MED1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 ACSS2 NR1D1 CHCHD3 PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 MEF2C PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 CCP110 MAPK12 TNPO1 HCFC1 PPARGC1A PPARGC1B CEP57 CETN2 CEP164 ACTR1A PCM1 NRF1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HSPA9 HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 ALAS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 HAUS7 CEP70 CEP72 CEP192 PCNT TUBA4A CEP76 CEP78 PLK4 ATP5F1A SIRT3 ATP5F1B ODF2 CEP152 NEDD1 ALMS1 MTX2 PPARA CEP41 CYCS CEP43 IFT172 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 CCT3 RPGRIP1L DMAC2L WDR35 IFT88 SMO TCP1 ESRRA KIF3A TTC21B WDR19 IFT122 MKS1 MT-ATP6 CCT8 CCT5 CCT4 CEP97 TUBB4B KIF17 TUBB4A ATP5PF ATP5PD ATP5PB ATP5F1C HSP90AA1 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 ATP5PO HDAC6 RHO CNGB1 PPP2R1A CPAP ATP5MC2 ATP5MC3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 TFAM TFB2M RXRA DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 SAMM50 PDE6D HDAC3 MTX1 MAPRE1 PAFAH1B1 TBL1X DYNC1I2 NCOA1 NCOR1 CLASP1 TBL1XR1 DYNC1H1 NDE1 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 CALM1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 NCOA2 NCOA6 CDK1 GLUD1 GLUD2 SIRT4 CRTC2 CRTC3 CRTC1 HELZ2 CREBBP CHD9 MICOS13 MICOS10 CHCHD6 MTERF1 RAB8A GABPA SIRT5 TGS1 PPRC1 MEF2D PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 TFB1M RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MRM3 RCC1L RPUSD4 NGRN DDX21 RPUSD3 NOP58 RPS4Y2 RPS27L RPS4Y1 TRMT10C PRORP RPS4X RPS15 ELAC2 RPS14 RPS17 HSD17B10 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction SOX17 POU5F1 FKBP6 SPAM1 LMNB1 CXCR4 PRDM1 PDPN FIGNL1 TEX12 TEX15 MSH4 MSH5 CD9 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B HVCN1 MND1 FIRRM REC8 SYCP3 STAG3 DMC1 PSMC3IP MLH3 CDK4 PRDM9 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L SPO11 H2BC21 SUN2 SUN1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 EOMES H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 NANOS3 CBFA2T2 H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 BMP4 H2BC1 POT1 TERF2IP H2AC20 NANOG HSPA2 CDK2 MLH1 B4GALT1 TFAP2C UBE2I CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 ZP3 ZP2 TET2 ZP4 BLM MRE11 BRCA1 BRCA2 RBBP8 NBN TOP3A RPA1 RPA2 RAD50 RAD51 RAD51C RPA3 ATM ATR DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN3 PAIP1 LSM5 LSM4 SKIC2 LSM3 LSM2 LSM7 LSM6 DDX6 LSM1 PATL1 CNOT4 EDC3 EDC4 CNOT6 DCP1B CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT11 DIS3 XRN1 SKIC8 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 CNOT6L EIF4A2 EIF4A1 DCP1A TUT7 TUT4 EIF4G1 HBS1L NT5C3B SKIC3 EIF4A3 DCPS PAN2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes IKBKB SQSTM1 UBC MYD88 RPS27A IRAK1 NGF TRAF6 UBA52 NGFR PRKCI UBB RIPK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription RBPJ MAML2 FCER2 MAML1 MAMLD1 HES1 MAML3 EP300 GZMB NOTCH2 HES5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPKAPK2 MAPK1 MAPK8 ATF1 MAPK3 ATF2 PPP2R1B PPP2R1A PPP2CA PPP2CB MEF2C MAPK9 MAPK14 MAPK11 MAPK10 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK HDAC1 H2AC20 ERCC6 MBD3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MTA2 RBBP4 MTA1 MYBBP1A MTA3 TTF1 RBBP7 ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP85 NUP62 NUP43 RCC1 RAN NDC1 SEC13 RANGAP1 UBE2I NUP155 NUP133 SUMO1 NUP93 NUP35 NUP54 NUP205 NUP37 POM121 NUP107 NUP188 KPNB1 TNPO1 NUP160 AHCTF1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere ACD LIG1 PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 BLM RPA3 WRN DNA2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 AKR1D1 CYP46A1 CYP27A1 CYP39A1 HSD3B7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 ANAPC4 NEK2 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 UBB UBC BUB3 RPS27A MAD2L1 ANAPC15 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation HPGDS GSTA3 GSTA1 GSTM4 AKR1A1 GSTT2 GSTT1 ESD GSTT2B GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 GSTZ1 GSTA5 GSTA4 GSTO1 CHAC1 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GSTA2 GGT3P GGT1 GCLM MGST3 MGST1 GSTP1 MGST2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance CLTC PCSK9 AP2S1 CLTA AP2A1 LDLR LIPA AP2A2 AP2B1 NCEH1 LDLRAP1 AP2M1 LSR APOB NPC1 SOAT1 SOAT2 NPC2 CES3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes ITGA5 PIEZO1 CACNA2D1 SPP1 CACNG7 GJA1 CACNA1H PANX1 HSPG2 CACNB2 AKT1 ITGB3 P2RX7 ITGB1 CACNB1 CACNB3 ITGAV SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants MAPK1 DUSP9 DUSP6 DUSP16 DUSP7 DUSP10 DUSP8 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis COQ9 COQ7 COQ6 COQ5 COQ2 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A STARD7 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN LAT2 SYK FYN BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs HPGD PTGS2 ALOX15 ALOX5 LTA4H PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis ADSS2 GART PAICS PFAS IMPDH1 ADSL IMPDH2 PPAT ATIC GMPS ADSS1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins JUN RELA IRAK1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A IL1B PELI1 MMP1 MMP2 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 MAPK8 SOCS1 IKBKB SQSTM1 MYD88 FCER2 CANX PTGS2 ALOX5 RBX1 SDC1 HIF1A SNAP25 GATA3 LYN INPP5D ARF1 RALA RPLP0 IL1RN PITPNA BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CSF1R MAP3K7 FPR1 MAP2K6 TCP1 BCL6 SMAD3 NFKBIA TAB1 TRAF2 TEC TRAF6 USP14 NOD1 ITGAM ITGB2 NOD2 IRS1 USP18 PPP2R1B IRS2 PPP2R1A PIK3CB FGF2 TNFRSF1B SOX2 TNIP2 PTPN13 INPPL1 TWIST1 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 SHC1 PPP2R5D PIK3R2 PIK3R1 RHOU ALOX15 MAPK1 BIRC5 CHUK MAPK3 PTPN11 CDC42 LIFR PPP2CA PPP2CB HNRNPF CASP1 OPRM1 IFNG MCL1 CD86 PTK2B CD80 VEGFA IL22 POMC CXCL1 NFKB2 JAK2 HNRNPA2B1 IL2RG MMP9 FBXW11 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B CCL3L3 CCR5 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 P4HB PRTN3 TIMP1 POU2F1 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FN1 BRWD1 BLNK BTRC S1PR1 JAK3 CD4 LCN2 STAT2 MMP3 IL23R IL13RA2 IL13RA1 IL4R IL23A CDKN1A FSCN1 NDN LIF NANOG IGHE OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 IL11 PIM1 IL19 IL16 IL17RE OSMR PSMD8 IL17RB PSMD6 HMOX1 IL31 IL17C PSMD7 IL11RA SOCS2 IL7 PSMD2 IL7R IFNL2 PSMD3 IFNL1 AKT1 IFNL3 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A UBE2V1 HSPA8 VAMP2 ICAM1 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 RAG2 RAG1 IL32 CASP3 IL34 IL1RL1 IL33 TGFB1 LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 RORC RORA TNFRSF1A HSP90AA1 CBL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 MAP2K1 HSP90B1 H3C15 STAT3 NFKB1 ITGAX FASLG IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs JOSD2 UBC RAD23A JOSD1 ATXN3L RPS27A VCP RAD23B PRKN UBA52 ATXN3 UBB SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT CLTC CLTB FZD7 WNT5B WNT5A ROR1 CLTA ROR2 AP2A1 PRICKLE1 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 PRKG2 AP2S1 ITPR1 ITPR2 AP2B1 ITPR3 WNT10A DPY30 WNT7B WNT7A BTRC PRKCB RAC1 WNT6 PPP3CA WNT2 PPP3CB GNAT2 PRKG1 PLCB3 WNT2B PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 WNT16 NFATC1 GNAO1 TCF7L2 TCF7L1 HDAC1 LEF1 PIP5K1B TCF7 CTNNB1 ASH2L TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 RSPO3 TNRC6A TNRC6B TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 VPS29 PSMD1 VPS35 WLS VPS26A TMED5 PRKCA TLE5 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SNX3 PSMA2 CSNK1G2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 SFRP1 PSMB5 CSNK1E SFRP2 WIF1 UBB PSMB2 SOST PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 MEN1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PRKCG GNG10 CHD8 GNG12 CAV1 CBY1 SOX3 GNG11 SOX17 GNG13 XIAP RNF146 SRY SOX6 GNB2 SOX7 SOX4 GNB1 BCL9L RUVBL1 CTNNBIP1 SOX13 MAP3K7 GNB4 USP8 PYGO1 GNB3 BCL9 PYGO2 GNB5 GNGT1 TLE4 TLE2 TLE1 GNGT2 CUL3 TNKS GNG3 SMURF2 GNG2 GNG5 GNG4 GNG7 GNG8 USP34 ARRB2 SCRIB VANGL2 WDR5 AXIN2 RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 LGR6 KLHL12 LGR5 WNT3 CCDC88C RSPO4 LGR4 DACT1 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B DAAM1 H2BC21 PFN1 EP300 PARD6A SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 H3C15 PPP2R5E FRAT2 H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 H2BC1 H2AC20 RHOA PPP2CA PPP2CB SMURF1 CAMK2A AMER1 CALM1 GSK3B CSNK1A1 AXIN1 APC PORCN CDC73 LEO1 KAT5 CTBP2 CTBP1 CREBBP TERT WNT10B WNT9B SEM1 SMARCA4 WNT4 TLE3 SKP1 CUL1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4 AGRN B3GALT6 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MBD3 GATAD2B GATAD2A CHD3 DPF1 HDAC2 DPF2 DPF3 CHD4 SS18L1 ARID1A ARID1B SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 SMARCC1 MTA1 SMARCC2 MTA3 RBBP7 ACTB SPOCD1 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 PIWIL4 H3-3B H3C8 H2AC8 DNMT3L H2AC6 BCL7A H2AC7 BCL7C H2BC17 BCL7B SMARCA2 H2BC12 SMARCA4 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 C19orf84 H3C15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 MBTPS1 HSP90B1 MBTPS2 DDIT3 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control VCP RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 TCF25 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 ZNF598 RPS27 RPS23 ANKZF1 ASCC2 KLHDC10 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling CRLF1 TYK2 CANX IL6ST JAK2 IL27RA EBI3 STAT3 JAK1 STAT1 IL27 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o DPM3 DPM1 DPM2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport SLC22A5 RSC1A1 SLC14A1 SLC14A2 SLC22A4 SLC67A1 SLC22A2 SLC22A3 SLC22A1 RUNX1 SLC22A15 SLC22A16 SLC47A2 SLC47A1 SLC25A26 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RELA NFKB1 BST2 NPM1 ITCH PCBP2 NLRP3 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 UBE2I MAVS TKFC YWHAB FKBP1A RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 YWHAQ PYCARD YWHAG YWHAH YWHAZ SFN PPIB TRAF3 TRAF6 UBA52 TLR7 IFIH1 RIPK3 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 TOMM70 UBB RPS17 RPS15A RPS16 RPS19 UBC SP1 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 BCL2L1 EP300 RPS13 RPS12 RPS9 RPS7 RPS8 PPIA IRAK2 RPS5 RPS6 PSMC6 RPSA RPS3A RUNX1 RPS26 EEF1A1 RPS25 RPS28 KPNA2 PDPK1 RPS29 RPS20 FAU RPS21 RPS24 PPIH RPS27 RPS23 PPIG CAV1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSME1 PSMB10 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMD9 PSMD4 PSMA5 PSMD5 PSMA6 PAAF1 PSMA3 PSMA4 PSME3 PSMA1 PSME4 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMD12 PSMG4 PSMD11 PSMG1 PSMG2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBC RPS27A CBL UBA52 MKNK1 SPRY2 MAPK1 MAPK3 BRAF PTPN11 UBB PPP2R1A BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors STAB2 APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 HSPH1 HYOU1 IGLV2-11 SCARF1 S100A9 IGLV1-40 APOB HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 HMGB1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 COL4A2 COL4A1 FTH1 PRDX1 SCGB3A2 MASP1 SPARC FTL V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 APOE V2-8 V1-20 CALR V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD36 LRP1 COL1A1 SSC5D COL1A2 STAB1 CD5L SAA1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CCL2 EDNRA CCL1 EDNRB CCL19 PROK2 CCR2 CCL17 AVPR2 PROK1 AVPR1A CCL16 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP NMS PDYN NMU AGTR2 FPR3 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 CCKAR PNOC SSTR3 EDN1 GPR37 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR MT-RNR2 INSL3 F2RL1 INSL5 PENK F2RL2 F2RL3 APLN GPR37L1 KEL PMCH NLN PPY MC1R GHSR MC4R F2R MC3R UTS2 GAL NTS MCHR2 NPB NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R NPY1R APLNR BDKRB2 BDKRB1 QRFPR XCL2 XCL1 PYY HEBP1 CCK GPER1 HCRTR2 HCRTR1 NPY5R KISS1 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 OPRD1 ACKR1 C5AR2 C5AR1 C5 AGT PF4 C3 FPR1 NPY CXCR1 CXCR2 OPRM1 SST OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling IL18RAP IL18R1 IL4 IL18BP IL13 IL18 IL37 ALOX5 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants HRAS NRAS KRAS ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins YWHAH SFN YWHAZ DYNLL1 DYNLL2 PPP3CC E2F1 BID TP63 PPP1R13B MAPK8 BCL2L11 TFDP1 TFDP2 BAD BBC3 BCL2 PMAIP1 AKT2 BMF YWHAB YWHAE TP73 TP53 AKT1 PPP3R1 TP53BP2 YWHAQ YWHAG AKT3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions PARD6G CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 PRKCI CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 PATJ CLDN18 CLDN17 CLDN16 PARD6A F11R CRB3 PARD6B PARD3 CLDN5 PALS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C S100A9 S100A8 YWHAE YWHAQ YWHAG YWHAH FLNA LIMK2 PRKCB RAC1 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 CTNNB1 CDH1 YWHAB MYL9 XPO1 CYFIP1 NCKAP1 PRKCD AR PRKCA NCF1 SFN YWHAZ NCF2 NCF4 CFTR BRK1 BTK CFL1 CYBB CYBA ACTB NOXO1 MEN1 MAPK14 MAPK11 PAK1 MYLK NCKAP1L WASF1 PAK2 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX3 ABL1 NOX1 ROCK1 ROCK2 WIPF1 WIPF2 CYFIP2 WIPF3 NUP107 LIN7B NUP160 CIT IQGAP1 NUP85 PKN3 IQGAP2 IQGAP3 NUP43 RANBP2 SEC13 GOPC CDC25C PKN2 NUP133 PKN1 CDKN1B NUP37 ERCC6L WASL ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 MRTFA KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 DAAM1 H2BC21 ZW10 NCK1 PFN1 WAS MAD1L1 PFN2 H3-3B CDCA8 H3C8 PRKCZ H2AC8 PMF1 SKA1 H2AC6 SKA2 PAK3 H2AC7 DSN1 H2BC17 WASF3 DVL1 DVL2 H2BC12 DVL3 H2BC13 SRGAP2 H2BC14 SCAI H2AJ RCC2 KTN1 PDPK1 H2BC15 NDC80 ZWINT H2BC11 DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PIK3C3 H3C15 PPP2R5E NUF2 KIF14 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 H2BC1 RHOC RANGAP1 RHOD H2AC20 CKAP5 DYNLL2 RHOQ RHOA RHOB KIF2A KDM1A MAPK1 INCENP PIN1 BIRC5 EVL KIF2C RTKN KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 MAPK3 CENPA AURKB NSL1 CENPC CDC42 PPP2CA RHPN1 PPP2CB RHPN2 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ DLG4 SPC24 CALM1 SPC25 MAD2L1 CENPS PLK1 NCOA2 CTNNA1 PPP1CB PPP1R12A PTK2 CLIP1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation MAPK1 SOS1 SHC1 INS MAPK3 GRB10 IRS1 INSR IRS2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) RPS6KA1 JUN H2BC9 H2AZ2 CXCL8 H4C9 VENTX H2BC8 RELA H2BC5 H2BC3 MAPK7 STAT3 H2BC1 CDKN1A NFKB1 CDKN2A H2AC20 MAPK1 CDK2 CEBPB MAPK3 EHMT2 EHMT1 IL6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDKN2D ANAPC11 CDKN2C CDC23 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 CDKN1B ANAPC4 ANAPC5 FZR1 ANAPC1 ANAPC2 IGFBP7 CDK6 IL1A CDK4 H2AX UBB H2AB1 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS CCNA2 CCNA1 H2BC11 RPS6KA3 RPS6KA2 H3C15 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription HOXC8 HEYL FOXF1 SP1 ILF3 ZEB2 SNAI1 PRDM8 BHLHE22 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses CGAS TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC TRIM21 STAT6 MRE11 NLRC3 IFI16 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling ADAR ARIH1 PPP2R5A STAT3 NPM1 HSPA1L DHX9 HSPA2 CHUK SPHK1 EIF2AK2 ISG15 MAP2K6 STAT1 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB FANCC PPP2CA PPP2CB PRKRA TARBP2 UBE2I MAVS SNCA SUMO1 DUS2 TRIM25 CENPS CENPX ILF2 CDK1 ILF3 IKBKG PPP2R1B PPP2R1A PTPN2 DNAJC3 NCK1 FAAP100 FAAP24 HSPA8 FAAP20 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A TP53 UBE2L6 HERC5 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF10 FGF2 EGF FGF4 FGF7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LMF1 GPIHBP1 FGF21 MBTPS1 FURIN PCSK6 LIPC CREB3L3 APOC2 PCSK5 ANGPTL3 MBTPS2 APOA4 APOA5 ANGPTL8 ANGPTL4 LPL LMF2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response XIAP CARD8 CYCS UACA BAK1 CDKN2A GSDMD GSDME BAX MAPK1 C1QBP AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance PCNA RUVBL1 NPM1 WRAP53 PIF1 GAR1 CTC1 CENPW CENPX RUVBL2 OIP5 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 RBBP4 RTEL1 CHTF8 DAXX ATRX RSF1 RBBP7 PRIM2 MIS18A PRIM1 POLA1 H2AX DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 KNL1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC1 H3-3B STN1 TEN1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 CDK2 ITGB3BP CENPA CENPC FEN1 CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L BLM WRN HJURP RFC5 RFC3 RFC4 TERT RFC2 RPA1 MIS18BP1 RPA2 RPA3 CCNA2 CCNA1 DNA2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors PIAS4 PIAS3 TFAP2B SUMO3 SUMO2 TFAP2C UBE2I PIAS1 CDKN2A SUMO1 MDM2 FOXL2 MITF HIC1 SP3 MTA1 TP53BP1 TP53 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3 CRIPTO DPPA4 ZIC3 EPHA1 FGF2 SALL4 STAT3 SOX2 POU5F1 NANOG SALL1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B2 SRD5A3 HSD3B1 CGA LHB HSD17B3 HSD17B12 SRD5A2 CYP17A1 SRD5A1 POMC SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 RXRA APH1A TGFB1 GIPC1 TGFBR1 PSENEN TGFBR2 NCSTN APH1B PSEN2 PSEN1 ACVR2A INHBA INHA TGFB2 SP1 TIMP2 FGF2 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B TIMP1 MYF5 TCF3 HELLS TCF12 KLF16 ARRB1 ARRB2 RARA MMP14 MMP16 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression TP53 PRDM1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 GP9 ADAMTS13 VWF GP1BA GP1BB AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation NTRK1 PIK3CB PIK3R2 PIK3R1 NGF PIK3CA IRS1 RHOA IRS2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 H2BC1 LIG4 MDC1 PAXIP1 RNF168 NSD2 PIAS4 BRCC3 PRKDC MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN BARD1 H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2BC15 DCLRE1C RIF1 H2BC11 ATM POLL NHEJ1 POLM TDP2 TDP1 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy CETN1 PARK7 UBC DYNC1LI1 CFTR RPS27A DYNC1I1 HSP90AA1 DYNC1LI2 DYNLL1 UBE2V1 PRKN DYNC1H1 UBA52 ARL13B DYNLL2 HDAC6 PCNT HSF1 VCP IFT88 DYNC1I2 UBE2N UBB RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter CRCP TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 POLR1C POLR1D INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease RELA ARPC1B NPM1 ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 NR3C1 IRAK1 NCKIPSD IL6 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 VAV3 MED4 MED6 MED7 UBE2N VAV1 VAV2 MAPKAP1 NEDD4L C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 V1-11 PTGES3 V1-16 V1-13 MAPK8 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB V2-8 V1-20 V1-9 TAF7L V5-4 FEN1 V1-7 V5-1 V1-5 UBE2I V1-3 V5-6 SUMO1 C1QA C1S UBE2D2 ELOB V4-6 ELOC V4-2 RBX1 V4-1 VHL RNMT CCNH POLR2A ISCU SNAP25 POLR2B POLR2C POLR2D SYT1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 GNG10 GNG12 GNG11 GNG13 KPNA7 KPNA4 GNB2 KPNA5 GNB1 GBP1 KPNA3 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 CDK8 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 ACTG1 PPP1CC TXNRD1 PML DYNC1LI1 DYNC1LI2 FCGR2A DVL1 DVL2 DVL3 TXN RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 HBB CD33 CHUK TJP1 DYNC1I2 CDC42 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X NFKB2 JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 PRKACG IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 FCGR3A BRD4 RPS18 CRBN RPS3 MYH2 MYO10 IGLC7 RPS2 IGHV3-53 MYO1C RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 PRKAR1B RPS5 PRKAR2B RPS6 PRKAR1A RPSA PRKAR2A RPS3A PRKX RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HBEGF HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E RNF213 ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A GBP2 GBP4 TLR6 IKBKE IRF7 CYFIP1 NCKAP1 BRK1 RAN NEK2 PDIA3 TUBB CYBA VPS36 VPS25 CBX1 SNF8 CHMP1A RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L SUGT1 WASF1 PAK2 IGF1R WASF2 CALM3 CALM2 CAV1 BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A WIPF1 WIPF2 FXYD4 WIPF3 FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 FCGR1A SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C DUSP16 TMPRSS2 WASL SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 NRP1 MAP2K1 MAP2K2 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 ENO1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 PGK1 ARID4B SAP30 MAP2K4 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD MAP2K7 TAB3 TAB2 NFKBIB ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 ARIH1 IFNA13 IFNA14 ADCY9 IFNA16 SAP30L IFNA17 ADCY4 BAG2 MED9 ADCY3 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 FGR GGT5 PATJ VPS39 VPS18 LARP1 ITPR1 VPS11 ITPR2 GGT1 VPS16 ITPR3 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 NOS2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 P2RX7 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 P2RX4 PARP8 TUFM GEMIN4 GEMIN5 CRK GEMIN6 GEMIN7 GNAS GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 GSDMD DNAJC10 NMT1 VPS33B RIPK3 CORO1A IL18 HGS IL1A RAB5A KPNB1 IL1B TLR4 BCAP31 FNTA CHMP4C UPK1A EPCAM CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 STAM RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IL10 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 AHCYL1 TAF9B KPNA2 MAP3K7 H2AC1 STAM2 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 GNAZ CD163 SMAD4 RHBDF2 ADORA2B SMAD3 ADAM17 NFKBIA SCAP MAVS CYFIP2 TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 WASF3 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 DPEP2 CRNKL1 CDC40 DPEP1 ATP6V1H MAPK1 DHX9 CSTF3 CSTF2 ELMO2 MAPK3 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D SRC RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 CALM1 DOCK2 CAMK2G HNRNPH2 DOCK1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CTSG CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 LTF TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 CD9 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 MET ACOT2 STX1A CDH1 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 C3 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B TRIM27 HSP90AA1 CBL EGFR PLCG1 RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 SFPQ IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 GNAI3 GNAI1 GNAI2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 SH3GL3 EPS15 SH3GL2 SH3GL1 ST3GAL1 ST3GAL2 ST3GAL3 YES1 EEF2 CTSL SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses RELA PPIB NFKB1 BST2 TRAF3 TRAF6 UBA52 ITCH TLR7 IFIH1 RIPK3 KPNB1 PCBP2 UBB TOMM70 NLRP3 UBC RPS27A TBK1 IRF3 NFKBIA STING1 MAVS IRAK2 PPIA TKFC FKBP1A RUNX1 RIGI RCAN3 KPNA2 NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 PPIH PPIG PYCARD PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A APOL1 COPS3 COPS6 HMGB1 COPS5 COPS8 PRDX1 CHMP3 CHMP6 CHMP7 PLA2G6 V2-11 V3-4 DCTN6 V3-3 DCTN5 V2-17 DCTN1 GJC1 V3-2 DCTN4 GJC2 V2-15 GJA3 V2-19 V1-11 GJA10 GJA5 CLTCL1 GJA4 V1-16 MAN2A1 GJA9 V1-13 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 V2-8 GJB5 V1-20 GJB7 CHM TMED2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 CD59 DNM3 CD55 V4-6 V4-2 V4-1 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 CD163 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 HP STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 HBB TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 APOA1 COG8 COG7 COG6 COG5 COG4 IGHV3-23 COG3 RAB27B COG2 COG1 IGLV RINT1 RAB30 IGLV2-8 RAB36 IGKV1-16 TF KIF16B IGKV1-17 SAR1B KDELR2 IGKV1-12 KIF20B IGHV3-7 COPB2 IGHV3-9 COPA IGHV3-30 TMED10 ARL1 IGHV3-33 AP2S1 KIF3B AGTR1 IGKV1D-39 MAN2A2 VTI1A LDLR IGKV1D-33 SERPINA1 KIF3C RAB6B IGKV2D-28 RAB39A IGKV4-1 KIF18B IGHV7-81 KIF4B AP2B1 ALPP IGKV2D-30 KIF4A IGHV4-59 ALB COPE IGHV1-69 KIF12 KIF11 USE1 IGLV2-11 BICD1 S100A9 RABEPK IGLV1-40 BICD2 IGLV1-47 KIF15 KIF19 IGLV6-57 IGLV2-14 MAN1A2 F5 IGLV1-44 KIF13B F8 TMED3 KIF1C IGKV3-15 KIF1B IGKV3-11 IGKV2D-40 MAN1A1 IGHV3-11 KIF1A IGHV3-13 TMED7 TMED9 IGLV7-43 IGKV1D-16 NAA30 IGKV1D-12 KIF25 COPZ2 IGLV1-51 IGLV2-23 KIF22 STX4 KIF6 BET1L IGKV3-20 KIF27 COPZ1 SH3KBP1 SLC2A8 IGHV4-34 RAB33B IGHV1-2 KIF9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 CD3G IGHV NAA35 CD3D IGKV2-29 NAA38 VAMP4 IGKV2-28 PAFAH1B3 IGLC3 ARF5 NAPA NAPB IGLC1 NBAS CHRM2 IGLC2 TMF1 STX16 IGKV3D-20 STX18 GOSR1 GOLGA2 NAPG STX10 IGKV2-30 IGLV3-19 CYTH3 ARFRP1 IGHV2-70 IGHV2-5 CYTH2 IGLV3-1 CYTH4 IGHV3-48 CUX1 IGLV3-25 VPS51 CD4 IGLV3-27 VPS53 VPS52 IGKC IGKV1-39 MAN1C1 IGLV3-21 BNIP1 STX6 IGKV1-33 VPS54 CYTH1 RIC1 IGLC7 IGHV3-53 MYO1C GALNT2 ARCN1 IGKV5-2 RGP1 KIF26A IGLC6 IGKV1-5 KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB CALR PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A COL1A1 COL1A2 SSC5D STAB1 CD5L SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 STAB2 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 HSPH1 SNX2 FNBP1L HYOU1 SNX9 SNX5 SCARF1 TBC1D8B PUM1 HBA2 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 HSP90AA1 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 COLEC12 KIF20A MSR1 TMEM115 CNIH2 COLEC11 CNIH3 SCARA5 HSP90B1 MCFD2 MARCO MIA2 COL3A1 PPP6R1 COL4A2 COL4A1 TRAPPC6A FTH1 TRAPPC6B SCGB3A2 SEC22A SEC22C MASP1 FTL SPARC STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF APOE PLIN3 GGA2 GGA1 GGA3 CD36 LRP1 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 SAA1 TGFA HPR HPX IGHA1 IGHA2 EREG AMBP BTC JCHAIN EPGN AKT3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDC7 CDK2 CDC45 PRIM2 PRIM1 POLA1 POLA2 POLE MCM10 RPA1 DBF4 RPA2 RPA4 MCM7 MCM8 POLE4 GMNN RPA3 MCM3 MCM4 POLE2 MCM5 POLE3 MCM6 MCM2 ORC5 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle TRAK1 TRAK2 RHOT1 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SLBP LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants LRP5 KREMEN1 KREMEN2 DKK1 DKK2 DKK4 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade SERPING1 CFD C3 GZMM CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 CD81 C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S FCN1 C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC FCN2 FCN3 CRP COLEC10 PROS1 F2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription SGK1 NAB1 NAB2 LYL1 REST F3 ATF1 DNM2 SRF ARC TRIB1 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 SH3GL3 ID1 CDK5 VGF ID4 FOSB EP300 ID3 JUNB CDK5R2 MEF2D TCF12 FOS CHD4 ELK1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding OGG1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency NAGS TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway CREBBP TBK1 IRF3 TRAF3 EP300 MAVS RNF135 RIGI IFNB1 IFIH1 TRIM25 IKBKE TRIM4 IRF7 SIKE1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCD4 TCN2 CD320 LRP2 ABCC1 LDLRAP1 TCN1 LMBRD1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres ACD TINF2 PCNA TERF1 TERF2 RUVBL1 POT1 TERF2IP WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 BLM RTEL1 CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 RFC5 POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 CHTF18 RFC2 TERT RFC1 STN1 RPA1 TEN1 RPA2 RPA3 CCNA2 CCNA1 DNA2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GUSB SGSH GNS ARSB GALNS HGSNAT NAGLU HYAL1 GLB1 IDS IDUA DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm YAP1 SMAD2 SMAD3 TBXT LEF1 TCF7 TEAD2 NOTO TEAD4 FOXH1 FOXA1 CTNNB1 SHH FOXA2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D TBCE TUBA3C TUBA8 TUBA1C TUBA4B TUBA1B TUBA4A TUBA1A TUBB4B TUBB4A TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SLC24A2 SLC24A3 SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SRI CALM1 SLC24A5 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling XIAP RELA MAP3K7 NGF USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 NSMAF SMPD3 SMPD2 RIPK1 TBK1 IRAK1 ADAM17 NFKBIA TAB1 TAX1BP1 ARHGDIA YWHAE TNFAIP3 RNF31 SPATA2 TNFRSF1A OTUD1 UBE2L3 TRAF2 TNFSF10 TRAF6 PRDM4 FADD BIRC2 BEX3 BIRC3 CFLAR PRKCI USP21 TRIO RASGRF2 OTULIN ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 TRADD ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 CASP8 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN RACK1 TRAF1 ARHGEF3 ARHGEF4 ULK1 TNFRSF10B ARHGEF1 TNFRSF10A ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF TNFRSF10D ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 RBCK1 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 CHUK ECT2 ITGB3BP FAS ARHGEF33 FASLG NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 SHARPIN LINGO1 MAG OMG RTN4 HDAC2 UBE2D2 UBE2D3 IKBKE CASP2 STUB1 BAG4 UBE2D1 MAPKAPK2 UBA52 CYLD OTUD7B IKBKG UBB RIPK2 UBC RPS27A CASP10 TNF OPTN TAB3 TAB2 CASP3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 TASL HMGB1 CASP8 IRF5 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 TLR8 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling IL23R STAT3 IL23A RAP1B LMNB1 TCP1 CA1 STAT1 CDC42 CRLF1 CANX IL6ST IL27RA EBI3 HNRNPF IL27 P4HB SNRPA1 IFNG ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 JAK2 STAT4 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA PAK2 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP CTNNB1 IRF3 EP300 LRRFIP1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense SFN GBP1 CASP1 PIM1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation NR5A1 SRY SOX9 PTGDS DHH FGF9 WT1 AMH GATA4 DMRT1 ZFPM2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex PCNA MAX LIN52 CDC6 MYC HDAC1 E2F4 CDC25A E2F5 E2F1 RBBP4 TFDP1 TFDP2 LIN54 TOP2A LIN37 LIN9 RBL2 RBL1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB4 FGF2 THBS1 ITGB5 ITGA6 TNC TGFB1 VTN ACTN1 ITGA2 CASK SDC1 SDC4 ITGB3 ITGB1 SDC2 TRAPPC4 SDC3 ITGAV SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF BAIAP2 ABI2 ABI1 RICTOR ROCK1 ROCK2 PRKACG PRKACA PRKACB SPHK1 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 NOS3 PRR5 CRK PXN HSP90AA1 JUP PLCG1 SHB SH2D2A PIK3CB AXL NCK2 NCK1 RASA1 AKT2 PRKCZ PAK3 PRKCB RAC1 HRAS WASF3 BCAR1 VAV3 PDPK1 NRP1 PIK3CA ITGB3 VAV1 VAV2 TRIB3 MAPKAP1 ITGAV PIK3R2 PIK3R1 NRAS THEM4 RHOA CTNNB1 ELMO2 CDC42 MLST8 MTOR SHC2 HSPB1 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA FLT1 FLT4 NCF2 KDR NCF4 VEGFB PTK2B VEGFC VEGFD PGF BRK1 VEGFA MAPKAPK2 CTNND1 CTNNA1 CYBB CYBA MAPKAPK3 NRP2 CDH5 AAMP MAPK14 MAPK11 PAK1 AHCYL1 FYN NCKAP1L WASF1 PAK2 PTK2 WASF2 CAV1 AKT3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ARIH1 FURIN NPM1 OAS2 EIF2AK2 SPHK1 ISG15 MAP2K6 STAT1 FANCC PRKRA IRF3 TARBP2 MAVS RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 CENPX NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 FLNA PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 KPNB1 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B EIF4E2 FNTA FLNB MX2 DNAJC3 MX1 EIF4G3 EIF4G2 NCK1 EIF4A2 EIF4A1 UBE2L6 EIF4A3 HERC5 UBE2N ADAR PPP2R5A STAT3 HSPA1L DHX9 PIN1 HSPA2 CHUK MAPK3 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB PPP2CA PPP2CB EIF4E UBE2I SNCA GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 CASP1 NUP214 CENPS SFN ABCE1 UBE2E1 UBA52 CDK1 ILF3 JAK1 ACTB IKBKG UBB UBC PTPN2 RPS27A FAAP100 HSPA8 FAAP24 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation FGFR4 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B CHMP4A GABARAP CHMP2B CHMP2A UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A CHMP3 ATG12 ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B DYNLL2 TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 WIPI1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC25A10 SLC5A8 SLC5A12 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions COL4A2 COL18A1 COL4A1 ITGA5 ITGA3 ITGA9 COL16A1 ITGA1 ITGB8 COL13A1 ITGB5 ITGA6 JAM2 TNC JAM3 COMP IBSP SPP1 FBN1 ITGAX ITGB6 ITGA2 COL23A1 HSPG2 ITGA8 COL4A4 ITGA7 ITGAL COL4A3 VCAM1 LUM CD47 ITGA11 ITGA4 CD44 COL9A1 ITGAE COL9A3 PECAM1 COL9A2 AGRN ITGB7 CDH1 ITGAD KDR THBS1 FN1 VTN ITGA10 FGB FGA ITGAM ITGB2 FGG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 F11R BSG ITGB3 ITGB1 ITGA2B ITGAV PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening CACNB4 CACNG2 CACNA2D2 CACNG4 CACNA1B CACNA1A CACNA1E CACNB2 CACNA2D1 CACNA2D3 CACNB1 CACNB3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation FCGR1BP SEC61A2 SEC61A1 TIRAP TAPBP SEC22B B2M HLA-A TLR1 S100A9 PSMB10 S100A8 TLR2 FCGR1A STX4 CD14 TLR4 LY96 HMGB1 ITGAV HLA-H ITGB5 HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 CHUK LNPEP IKBKB MYD88 CD207 CALR CTSS MRC2 MRC1 VAMP8 PSMD8 PSMD6 TLR6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 NCF1 NCF2 PSMA5 NCF4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 CYBB FGA PSMB4 TAP2 CYBA FGG PSMB5 IKBKG TAP1 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSV CTSL FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGFBP3 FGFBP1 FGFBP2 FGF23 FGF22 FGF16 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis PCNA UBA52 POLH USP10 PCLAF USP43 REV1 ISG15 POLI UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling AKT2 PDE3B NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling OTUD5 ATG5 ATG12 UBE2D1 TRAF3 UBA52 UBE2K CYLD ITCH PIN1 IFIH1 ISG15 TRIM4 PCBP2 UBB UBC RPS27A NLRX1 TBK1 IRF3 NLRC5 UBA7 MAVS RNF125 RNF135 TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 UBE2L6 TRIM25 IKBKE HERC5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 CASP10 TP53 CASP6 ATM CASP1 CASP2 PIDD1 APAF1 NLRC4 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT6A CCT7 CCT4 CCT3 TCP1 ACTB CCT2 CCT8 CCT6B FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I POLR2J POLR2K POLR2L RBFOX2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 NCBP1 NCBP2 HNRNPA1 PTBP1 HNRNPM HNRNPF HNRNPH1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation PRKCB PRKCA STX4 PRKCG STXBP3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL11B SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A BCL7A DPF2 BCL7C BCL7B SMARCA4 SMARCC1 SMARCC2 ARID1A SMARCE1 ACTB RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling CREBBP RBPJ MAML2 MAML1 KAT2B KAT2A HES1 SNW1 EP300 JAG1 RUNX3 MAMLD1 MAML3 NOTCH1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand LIG1 PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression RXRA SP1 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B MYF5 TCF3 HELLS TCF12 KLF16 RARA SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM ADRM1 OAZ3 PAOX AZIN2 AZIN1 PSMC5 AGMAT PSMC6 SEM1 PSMC3 SMS PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNAT3 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 GNG12 GNG11 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A PIK3CA IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 PLD4 V2-19 V1-11 PLD3 V1-16 V1-13 PLD2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 PRKCD PLPP5 PLPP4 SYK AHCYL1 PRKCE DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses AP2A1 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 ARHGEF9 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 BCHE PRKCA SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT SLC6A1 CPLX1 RIMS1 ALDH5A1 DNAJC5 GIT1 HSPA8 VAMP2 CAMKK1 CAMKK2 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 SYN3 SYN2 HRAS SLC6A11 PDPK1 ARL6IP5 CACNA2D1 CACNA2D3 NRAS CHAT GRIP1 MAPK1 GNAT3 SLC6A4 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 SLC18A3 CHRNA1 CHRNA3 SLC17A7 CHRNA2 MAPK3 CHRNA5 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 GRIK4 GRIK1 GRIK2 GRIA1 GABRR3 CAMK2B GABRR2 GRIA2 GABRR1 CAMK2D NPTN SRC ACTN2 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B PICK1 NRGN GRIN2D GNAI3 AKAP5 GRIN1 GNAI1 DLG1 GRIN2A NCALD GNAI2 DLG2 CHRND DLG3 LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption MGAM SLC5A1 SLC2A5 SLC2A2 SI CLPS LCT PNLIP ALPI RSC1A1 PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF PIR PNLIPRP3 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLL1 DYNLL2 IFT172 KIFAP3 IFT52 IFT57 DYNC2H1 IFT140 WDR35 IFT88 KIF3A TTC21B WDR19 IFT122 KIF3B KIF3C DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 KIF17 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 TNPO1 CLUAP1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MTIF2 MRPS25 MTIF3 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MRPS17 MRPS15 MRPS16 MTFMT MRPS14 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME PON3 ABCB1 UGT1A3 SLCO1B1 SLCO1B3 PON1 ABCC2 CYP3A4 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA DDX21 ETF1 GSPT2 GSPT1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B UPF3A CNOT10 SMG1 SMG9 SMG7 SMG8 SMN2 SMG5 CNOT11 SMG6 UPF2 UPF1 PNRC2 NOP58 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 TYW5 GEMIN8 TYW3 TRMT5 DDX20 TYW2 TYW1 LCMT2 ADAR ADARB1 TNKS1BP1 RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPLP0 RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 LTV1 RRP1 GTF2H4 GTF2F2 FTSJ3 GTF2H5 EBNA1BP2 ISG20L2 CDK7 ERI1 ERCC3 LAS1L ERCC2 MNAT1 NOL12 RBM28 NOB1 RIOK2 RIOK1 TEX10 SENP3 GNL3 C1D NIP7 NOL9 EXOSC10 PES1 RIOK3 WDR18 WDR12 BYSL APOBEC1 BOP1 TSR1 APOBEC3C APOBEC2 MPHOSPH6 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B XRN2 HBS1L NT5C3B SKIC3 DCPS SKIC2 SLIRP MTPAP LRPPRC CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 NOP56 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PPP2R1A TP53RK STEEP1 TCERG1 EIF4A3 GPATCH1 RPS27 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 PRMT5 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 WDR77 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 PPP2CA ZRSR2 PRPF38A UPF3B NOP2 MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 TENT4A PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA LSM10 SNIP1 NCBP1 LSM11 MTREX NCBP2 TXNL4A PPP2R2A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 SEM1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 PHAX SNRNP27 PPIE TRUB2 SRSF3 MTERF3 SNRPE NSUN4 SRSF4 FASTKD2 PPIH MTERF4 PPIG SNRNP25 TFB1M SNRPF MRM1 SRSF5 MRM2 SNRNP200 MRM3 SRSF6 RCC1L SNRPC RPUSD4 SRSF7 NGRN SRSF8 RPUSD3 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 RPS4Y2 SNRNP48 RPS27L BUD13 RPS4Y1 TRMT10C PPIL3 PRORP PPIL4 RPS4X ELAC2 RPS15 FAM50A RPS14 TRNT1 HSD17B10 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 PAN2 PAN3 FASTKD5 POP5 TBRG4 POP7 CLNS1A OSGEPL1 SNUPN POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 DDX39B RPP38 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU EIF4E QNG1 EIF4B TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 GRSF1 NSUN6 DUS2 YWHAB QTRT1 HSPB1 GON7 ELAVL1 PSMD8 QTRT2 PSMD6 CTU2 ZFP36 CTU1 PSMD7 TSEN34 URM1 XPO1 PSMD2 LAGE3 KHSRP RPP14 PSMD3 TRDMT1 AKT1 RTRAF PSMD1 TRMT10A ADAT1 TNPO1 NUP214 TPRKB TRMT1 DIS3 PRKCD ADAT3 PRKCA TRIT1 ADAT2 YWHAZ PSMA5 XPOT PSMA6 TRMT6 PSMA3 FAM98B PSMA4 TRMT61A PSMA1 TRMT61B XRN1 RAN PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 CSNK1D EXOSC5 PSMB5 CSNK1E EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ZNF473 IGF2BP1 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 GAR1 NHP2 NOP10 DKC1 PELP1 ZC3H4 ZC3H3 EIF4A2 REXO2 IGF2BP3 EIF4A1 DDX49 TUT7 IGF2BP2 DDX47 TUT4 WDR3 DXO FCF1 ZCCHC7 NAT10 YTHDC1 THUMPD1 YTHDC2 PWP2 ZC3H18 WDR46 PNPT1 WDR43 RBM27 RRP9 RBM26 FBL TENT4B BUD23 SUPV3L1 UTP14A ZFC3H1 UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 PAIP1 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 RPLP1 DHX37 RPL34 RRP36 RPL10L UTP20 RPL8 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 UTP3 RPL18A PNO1 RPL36AL RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A WDR82 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 SKIC8 ZCCHC8 NCL TGS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP ACVRL1 BMPR2 AMHR2 GDF2 UBE2D1 SMAD9 SMAD5 GREM2 ZFYVE16 CER1 BMPR1B BMPR1A AMH NOG ACVR2B ACVR2A INHBA INHA CHRDL1 SKI SMAD1 SMAD4 SMURF2 SMAD7 SMURF1 SMAD6 TGFBR3 BMP2 UBE2D3 FSTL1 BMP10 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay ZFC3H1 PABPN1 SRRT TENT4A EXOSC7 EXOSC6 EXOSC5 EXOSC4 PAPOLG ZCCHC8 EXOSC9 NCBP1 MTREX NCBP2 C1D EXOSC8 EXOSC10 EXOSC3 EXOSC2 EXOSC1 RBM7 MPHOSPH6 ZC3H4 ZC3H3 WDR82 XRN2 DXO ZCCHC7 YTHDC1 YTHDC2 ZC3H18 RBM27 RBM26 TENT4B DIS3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis FTH1 FTL BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN AP3S1 TPD52 CLINT1 DNM2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 IGF2R DTNBP1 ARF1 GOLGB1 NAPA RAB5C TGOLN2 AP3B1 TXNDC5 OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SAE1 SUMO3 SUMO2 SUMO1 UBA2 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes HVCN1 KCNU1 CATSPERB CATSPER1 CATSPERD CATSPER3 CATSPERG CATSPER2 CATSPER4 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis CYP11B1 HSD3B2 HSD3B1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYP11B2 POMC SERPINA6 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP5 GP9 F9 F10 GGCX F8 GP1BA GP1BB F11 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex GPS2 NCOR2 NCOR1 TBL1XR1 TBL1X HDAC3 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes TLE1 TLE5 TLE3 TCF7L2 TCF7L1 CTBP2 HDAC1 CTBP1 LEF1 TLE4 TCF7 TLE2 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD OPLAH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNG13 GNB2 GNAQ GNB1 ADCY9 GNB4 PIK3R2 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB PECAM1 MLST8 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 PIK3CB CALCRL ADM TLN1 CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PIK3CA P2RY2 MMP14 GNG12 MAPKAP1 GNG11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MMGT1 ADD3 DMTN RHCG ADD2 ADD1 TUSC3 CTNS MAGT1 PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 RHAG AZGP1 ANKH MRS2 SLC66A1 NIPA1 NIPA2 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions IQGAP1 PIK3CB NCK2 PIK3R2 NCK1 PIK3R1 ACTN3 KIRREL3 ACTN2 KIRREL1 KIRREL2 ACTN1 MAGI2 FYN CD2AP SPTAN1 NPHS1 CASK WASL PIK3CA ACTN4 SPTBN1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX2 EHHADH ACBD5 AMACR ACOX3 SLC27A2 ACOT4 ACOXL NUDT7 CROT CRAT PECR HSD17B4 HACL1 ABCD1 DECR2 NUDT19 HAO2 ACBD4 ACAA1 PHYH ACOT8 SLC25A17 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling RELA MAP3K7 MAP2K6 IL1R1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 USP14 BTRC NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N NFKB1 CHUK IKBKB SQSTM1 MYD88 IRAK3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL1R2 PSMD13 NFKB2 TOLLIP PSMA7 PSMB6 PSMB7 PSMB4 MAP3K3 NKIRAS1 NKIRAS2 PSMB5 MAP3K8 IKBKG UBB IKBIP RIPK2 PSMB2 MAP2K4 PSMB3 IRAK4 UBC PSMB1 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism DMGDH CHDH SARDH ALDH7A1 BHMT SLC44A1 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) GP5 GP9 SERPING1 KLKB1 GP1BA F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression CXCL8 DCP2 HSPA5 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EIF2S2 EXOSC4 EIF2S1 EIF2S3 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP EIF2AK3 DIS3 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage IL18 CASP5 IL1B GSDMD CASP3 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis TPH2 DDC ASMT AANAT TPH1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs H2BC9 H2AZ2 POLR2A H4C9 POLR2B H2BC8 POLR2C H2BC5 POLR2D H2BC3 POLR2E RAN POLR2F H2BC1 POLR2G POLR2H POLR2I POLR2J H2AC20 POLR2K POLR2L IPO8 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B AGO1 H3C8 AGO2 H2AC8 TNRC6A H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling YWHAE NGFR NGF CASP2 BEX3 CASP3 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 SEPHS2 SECISBP2 EEFSEC RPS4Y2 SEPSECS RPS27L PSTK RPS4Y1 RPS4X RPS15 RPS14 RPS17 SARS1 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 PNPLA2 DGAT2 MGLL DGAT1 DGAT2L6 AWAT2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism PRSS1 TCN2 CD320 ABCC1 LDLRAP1 CTRB2 CUBN CBLIF MMAB CTRB1 AMN MMACHC MMADHC ABCD4 MTR MTRR LRP2 PRSS3 MMAA MMUT TCN1 LMBRD1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling CBL UBA52 FGF20 ANOS1 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET SOS1 ITGA3 STAT3 USP8 PIK3R1 NRAS PTPRJ RAP1B ITGA2 RAP1A STAM2 MET PTPN1 PTPN11 GGA3 SPINT1 HPN SPINT2 SRC HGFAC LRIG1 CRK LAMA5 SH3KBP1 LAMA2 LAMB3 LAMC3 CBL LAMB2 LAMA1 LAMA4 UBA52 LAMA3 LAMB1 STAM LAMC2 LAMC1 ARF6 RAB4A RAB4B DOCK7 HGS RANBP9 UBB RANBP10 RAPGEF1 UBC PTPN2 MUC20 RPS27A SH3GL3 EPS15 TNS4 SH3GL2 TNS3 SH3GL1 RAC1 HRAS GAB1 HGF PTK2 CRKL PIK3CA ITGB1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX CYP27A1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling GNG13 GNB2 GNAQ GNB1 PPP2R5D ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 MAPK1 GNGT2 GNAT3 PRKACG PRKACA PRKACB PLA2G4A PPP2CA PPP2CB GNA14 PPP1R1B PDE1B GNG3 PDE1A GNA15 CDK5 ITPR1 ITPR2 GNG2 CAMK2B ITPR3 GNG5 GNG4 CAMK2D GNG7 GNA11 GNG8 PDYN CAMK2A PDE4A PDE4D PDE4C GNAI3 GNAI1 GNAI2 OPRM1 CALM1 CAMK2G PRKCD PRKCA PLCB4 POMC PPP3CC PPP1CA PPP2R1B PPP2R1A PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX PPP3CA CAMKK1 PPP3CB CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 GNG10 NBEA PPP3R1 GNG12 GNG11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 FLRT1 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FLRT3 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FLRT2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis MBOAT7 MBOAT1 DDHD2 AGPAT2 MBOAT2 DDHD1 LPGAT1 PITPNB CPNE7 CPNE6 GPAM CPNE1 CPNE3 MFSD2A PISD PLA2G4A PLA1A PGS1 PTDSS2 PTDSS1 TMEM86B PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLA2G2A PLAAT5 PLAAT4 PNPLA8 LIPI LIPH ETNPPL PNPLA3 STARD7 PLB1 PLBD1 MIGA2 MIGA1 PLA2G3 PLA2G15 PHOSPHO1 PLA2G5 PLA2G10 PLA2G6 GPD1 PTPMT1 CHAT PLD4 PLD6 PLD3 CHKB CHKA STARD10 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 ACHE LPCAT1 PLD2 OSBPL10 ALPI GPD2 GNPAT PCTP LPIN1 LPIN2 MGLL PLA2G4F LPIN3 PLA2G4D PLA2G4E GPAT4 PLA2G4B PLA2G4C GPAT3 GPCPD1 CEPT1 AGPAT5 BCHE AGK PLA2G1B LPCAT4 AGPAT1 ETNK2 SELENOI LPCAT3 AGPAT3 ETNK1 AGPAT4 LPCAT2 LCLAT1 PLA2G2F PLA2G2D PLA2G2E PCYT2 PGP PLA2R1 CHPT1 GPD1L ABHD4 ABHD3 OSBPL8 CDS1 PITPNM1 PITPNM3 PNPLA2 OSBPL5 PITPNM2 CDIPT ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B AWAT2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 RXRB MYLIP REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors PHF20 AKT2 POU4F1 POU4F2 TP63 TP73 PPP1R13B TP53 PPP1R13L AKT1 TP53BP2 BANP AKT3 ZNF385A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling SOS1 PIK3R2 PIK3R1 KLRK1 NRAS PLCG1 BTK HLA-E GRAP2 LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 MYD88 TLR7 IRAK1 UBE2V1 TRAF6 IRF7 TLR9 UBE2N MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling RELA NGF SMPD2 IRAK1 ADAM17 NFKBIA ARHGDIA YWHAE TRAF6 PRDM4 BEX3 PRKCI TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ECT2 ITGB3BP ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 LINGO1 MAG OMG RTN4 HDAC2 CASP2 UBA52 UBB RIPK2 UBC RPS27A CASP3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling ATP5MC2 ATP5MC3 ATP5PB ATP5F1C ATP5MK ATP5F1D MT-ATP8 ATP5MJ ATP5F1E MT-ATP6 ATP5MC1 ATP5MG ATP5PO ATP5MF ATP5ME DMAC2L ATP5F1A ATP5F1B ATP5PF ATP5PD MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling PIK3CB SOS1 ANGPT4 SHC1 ANGPT2 ANGPT1 PIK3R2 PIK3R1 TEK DOK2 NRAS HRAS GRB7 PIK3CA PTPN11 GRB14 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER PREB STX5 LMAN2 FOLR1 CTSZ SEC24D CTSC SEC24C COL7A1 SAR1B MIA3 TMED10 SEC22B TMED2 SEC23A SERPINA1 AREG GRIA1 GOSR2 LMAN1 LMAN1L LMAN2L CD59 TGFA F5 F8 CNIH1 SEC24B CNIH2 CNIH3 MCFD2 SEC24A MIA2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A UPF1 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 NCBP1 RPS19 NCBP2 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants ERBIN SOS1 HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants KIT PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion UBC RPS27A RAB7A VPS33B CORO1A HGS RAB5A UBA52 UBB LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis AKR1B15 HSD17B14 HSD17B11 HSD17B1 HSD17B2 CYP19A1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC APPL1 DCC UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 CASP3 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 STAT5A STAT5B CBL CDKN1A PIK3R1 GRB2 NRAS UBA52 GOLGB1 MYO18A FLT3 ETV6 UBB PTPN11 UBC RPS27A BCL2L1 TRIP11 PIM1 HRAS ZMYM2 FLT3LG GAB2 PIK3CA SPTBN1 NOX4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 PTGR1 CYP4A22 CYP4B1 ALOX5AP MAPKAPK2 DPEP2 DPEP1 GGT1 ABCC1 ALOX15 CYP4F22 ALOX5 LTA4H LTC4S CYP4F3 CYP4F8 CYP4F2 CYP4A11 CYP4F11 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 RHOC CDKN1B PPP1R12A RHOA RHOB RAC1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 PPP1R12B DLG4 PPP1CB PRC1 CIT CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage IL18 IL1B CASP4 GSDMD CASP3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 GLTP CPTP CLN3 ESYT1 ARF1 ESYT3 ESYT2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC26A2 SLC22A5 GCKR SLC5A1 GCK SLC5A2 SLCO1B1 SLCO1B3 CP SLC6A5 SLC2A9 SLC67A1 SLC26A4 SLC26A3 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH AVPR1B SLC2A10 AVPR2 AVPR1A SLC24A4 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C SLC5A5 NUP42 NUP85 TPR NUP62 SLC35C1 NUP88 NUP43 RAE1 NDC1 SLC20A2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC24A1 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC17A5 SLC35A2 SLC35A3 SLC9A6 SLC33A1 AVP SLC9A9 SLC35A1 SLC29A3 SLC6A19 SLC4A1 SLC36A2 SLC27A4 SLC4A4 BSG SLC6A14 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC7A7 SLC5A7 SLC7A9 SLCO2A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 CSK HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 PTPRC HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 PAG1 HLA-DQB2 HLA-DQB1 LCK P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR NGF PRDM4 HDAC1 HDAC2 HDAC3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC5 HDAC1 HDAC3 HDAC8 HDAC9 HDAC6 HDAC7 MAMLD1 TBL1X RBPJ CREBBP MAML2 NCOR2 MAML1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 SNW1 HDAC11 HDAC4 HDAC2 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate TST ETHE1 SLC25A10 TSTD1 SQOR SUOX DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 APOA1 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 TLR4 HNRNPA1 STAT2 LY96 MAPKAP1 PDCD6IP FASN C4BPA C4BPB ATG14 HSP90AB1 CTNNB1 C4B_2 SDC4 SDC2 SDC3 RPTOR MLST8 GPC1 GPC3 UBE2I GPC2 GPC5 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H2AC25 NEK2 H2AC21 GTF2F1 GTF2F2 IFIH1 HSPA8 UBR4 NRBP1 PEX19 HNRNPA0 CD2BP2 HNRNPUL1 AUP1 PPIL6 ELAVL2 RICTOR H2AC1 CPSF7 SRRM1 VIM HNRNPC RIPK1 RBMX STING1 NFKBIA MAVS CLEC5A HSP90AA1 H2BC18 BECN1 DAXX H2AC19 H2BC26 H2AC14 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 CDC40 H2AC20 DHX9 HSPG2 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 SF3A1 SF3A2 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN WBP11 PRPF6 SNRPG SRSF2 PPIE NFKBIB SRSF3 F2 SNRPE SRSF4 SNRPF SRSF5 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNG13 GNB2 GNAQ GNB1 KCNJ11 ABCC8 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ACACB ADCY6 ADCY5 GNGT2 RAP1A PRKACG SLC2A1 SLC2A2 PRKACA PRKACB RAPGEF3 FFAR1 RAPGEF4 GNA14 GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 IQGAP1 GNAS GCGR GCG CHRM3 PPP2R1B PPP2R1A ACACA PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 CACNB2 PLCB3 PLCB1 PLCB2 ACSL4 ACSL3 ACLY CACNA1D FASN PPP2R5D STXBP1 INS ADRA2C SYT5 MLX ADRA2A PRKAA2 CACNB3 PRKAG2 PPP2CA STK11 PPP2CB CACNA1A CACNA1E STX1A TKT PRKAB2 KCNG2 AKAP5 GNAI1 GNAI2 AGPAT1 PRKCA CD36 SNAP25 KCNC2 CACNA1C PFKFB1 GLP1R ADIPOQ MLXIPL ADIPOR1 ADIPOR2 TALDO1 KCNB1 KCNS3 VAMP2 AHCYL1 MARCKS GNG10 GNG12 GNG11 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation PSMB3 PSMA5 PSMA6 PSMB1 PSMA3 PSMA4 PSMA1 PSMA2 PSME2 PSMB10 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB8 PSMB9 PSMB5 PSMB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC12 MUC17 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD TBXAS1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CBLL1 CTNNB1 RPS27A CDH1 CTNND1 UBA52 SRC UBB ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A4 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis SEL1L IHH VCP DERL2 ERLEC1 OS9 ADAM17 GPC5 P4HB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 DISP2 PSMC2 SCUBE2 NOTUM SYVN1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins ISCU RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants HRAS NF1 SPRED3 SPRED2 SPRED1 NRAS DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS NCAN CSPG4 CHSY1 BGN DCN BCAN VCAN CSPG5 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 PRSS3 CTRB2 CUBN TCN1 CBLIF CTRB1 AMN LMBRD1 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL HADHB HADHA PLA2G6 PLA2G4A LCLAT1 TAFAZZIN LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism ALDH4A1 PRODH PRODH2 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) VAMP2 SV2C SV2B SV2A VAMP1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism ADA2 SFTPB SFTA3 SFTPA1 ZDHHC2 SFTPA2 CTSH ADRA2C TTF1 ADRA2A DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 ADORA2B ABCA3 GATA6 ADORA2A CKAP4 SFTPD P2RY2 SLC34A2 SFTPC SLC34A1 CSF2RB CSF2RA ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide CA4 AQP1 HBA2 SLC4A1 CA1 RHAG CA2 HBB DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE ABCC6 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 FPR1 FPR3 APP SAA1 FPR2 HEBP1 ANXA1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 TGFB1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SMURF2 EP300 SMURF1 ADRM1 SRC MDM2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 RUNX3 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 CBFB IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 TRAV29DV5 IGLC3 TRBV7-9 TRBC1 IGLC1 IGLC2 IGKV3D-20 TRAV19 IGKV2-30 IGLV3-19 IGHV2-70 TRAV8-4 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 HLA-H HLA-B V2-11 HLA-C V3-4 HLA-F V3-3 V2-17 HLA-G HLA-E V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 CD19 V2-8 V1-20 TREM2 V1-9 V5-4 V1-7 V5-1 CDH1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD40LG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 C3 VCAM1 SIGLEC9 CXADR ITGB7 B2M HLA-A CD8B SIGLEC5 FCGR1A JAML CD99 ITGB2 COLEC12 ITGB1 CD33 ITGAL ITGA4 LILRA3 IFITM1 CD226 CD1D CD1C CD1B cd21 LAIR1 CD1A SLAMF7 LILRB2 SLAMF6 LILRB3 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD22 CD200 CD300A NCR1 NCR3 CD200R1 OSCAR HCST TYROBP LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 SELL KLRK1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 NCR2 SIGLEC1 SIGLEC8 KIR2DS2 SIGLEC7 SIGLEC6 PVR CD96 CD300LB CD8A TREM1 KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 CD300E KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 KLRD1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 CLEC2B FCGR2B CLEC2D NECTIN2 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRND CHRNA3 CHRNA4 CHRNG CHRNE PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UCK1 PUDP TK2 TK1 CDA DCK UPP2 UPP1 TYMP UCKL1 UCK2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCK ZAP70 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM12 ADAM19 SH3PXD2A TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 TICAM1 TLR3 RIPK3 CASP8 FADD SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin PRKCA HRAS SOS1 MMP3 HBEGF EGFR NRAS PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNQ1 CACNG4 KCNE5 AKAP9 CACNG6 CACNG7 CACNA1C CACNA2D2 CACNB2 CACNG8 CACNB1 KCNE1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 SPTAN1 POMT2 FYB1 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 ACTN3 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 CASK FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A IQGAP1 JUP RB1 RBBP4 WASL RBBP7 H2AX PIK3CB KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L NCK2 H2BC21 NCK1 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 SIRPG SKAP2 PIK3CA BANP SPTBN1 ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 H2AC20 KIRREL3 KIRREL1 KDM1A KIRREL2 MAPK1 MAGI2 CD2AP NPHS1 MAPK3 PTPN11 CD47 HDAC2 SRC ACTN2 SUZ12 SIRPA ARID1A TYROBP PTK2B PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 SIRPB1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 PTPN6 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 FYN SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 PTK2 CTSL NECTIN1 ACTN4 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 GUCY1B2 KCNMB4 GUCY1B1 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE5A NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis IMPDH1 ADSL IMPDH2 PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS CAD DHODH UMPS ATIC SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants FLT3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand ACD PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 RPA3 WRN DNA2 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin STAT5A STAT5B JAK2 LEP STAT3 SOCS3 IRS1 PTPN11 IRS2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors ZFP36L2 PAIP1 PABPC1 CNOT4 CNOT6 CNOT7 EIF4E EIF4B DICER1 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 BTG4 CNOT6L CNOT11 EIF4A2 EIF4A1 EIF4G1 PABPN1L EIF4A3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 STAM2 STON1 GPS1 STON2 COPS4 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 SGIP1 AP2S1 AGTR1 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 APOB SNAP91 M6PR SYT2 ARRB1 ARRB2 SCARB2 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 TGOLN2 CHRM2 HGS CD4 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 SLC18A3 DAB2 EPS15L1 EPN1 SYT9 GRK3 PICALM VAMP8 IL7R TFRC CFTR SYT1 IGF2R UBA52 STAM UBB UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG BTC EPGN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9 CYP2C8 CYP2J2 CYP1A2 CYP1A1 CYP1B1 EPHX2 CYP2C19 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GCGR ADCY7 ADCY6 GCG ADCY5 PRKACG PRKACA PRKACB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling APOA1 APOA4 APOB APOA5 GPIHBP1 APOE APOC2 APOC3 LPL APOA2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 CDH11 AGO1 AGO2 TNRC6A TNRC6B CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia CITED2 CA9 ARNT HIF1AN UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 VEGFA PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC HIGD1A PSMB1 RPS27A EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EPO DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) FMOD PRELP B4GALT1 OMD KERA ACAN OGN LUM SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants FLT3 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CSNK2A1 CLOCK DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l ALG9 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 GYG2 GYS2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system JUN TRIM6 IFNA2 TRIM5 TRIM2 IFNA8 TRIM3 CSH1 XAF1 ARIH1 RELA IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 TRIM45 NPM1 TRIM35 TRIM38 TRIM31 OAS2 TRIM34 IFITM3 IFNA10 IFITM2 IFIT5 IFNA21 IFI35 IFI30 IFIT3 IFNB1 EIF2AK2 IFIT2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR IRF8 IRAK1 IRF6 IRF9 SAMHD1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A KPNB1 IL1B KRAS PELI1 MMP1 FNTA MMP2 DNAJC3 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N ADAR IRF1 IRF2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 HSPA1L HSPA2 MAPK8 ATF6 BCL2L11 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 FCER2 CANX UBE2I PTGS2 SUMO1 ALOX5 UBE2D2 UBE2D3 ELOB ELOC RBX1 TRIM25 SDC1 HIF1A GH1 SNAP25 GATA3 LYN INPP5D TNFRSF12A TNFSF12 TNFRSF13C ARF1 TNFRSF11A CD40LG RALA RPLP0 LTBR IL1RN PITPNA LTB BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IFIH1 IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ACTB ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA KPNA2 TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 KPNA7 FKBP5 KPNA4 KPNA5 CSF1R GBP1 KPNA3 MAP3K7 FPR1 SPHK1 MAP2K6 TCP1 MT2A FANCC BCL6 SMAD3 SMAD7 ADAM17 NFKBIA MAVS TAB1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TRAF2 NUP43 RAE1 KPNA1 ILF2 NDC1 TRAF3 RANBP2 TEC TRAF6 SEC13 BIRC2 NUP155 NUP133 NUP210 BIRC3 NUP153 NUP93 USP14 BECN1 NUP50 NUP35 NUP54 NUP37 NOD1 ITGAM ITGB2 ACTG1 FLT3 NOD2 IRS1 USP18 PPP2R1B IRS2 EIF4E3 PPP2R1A PIK3CB IFIT1 PPM1B PML EIF4E2 FLNB FGF2 TNFRSF1B MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 SOX2 TNIP2 GRB10 HRAS PTPN13 INPPL1 FLT3LG TWIST1 IRF5 EIF4A3 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5A SHC1 PPP2R5D PIK3R2 PIK3R1 BST2 NRAS RHOU ALOX15 PTPRJ MAPK1 BIRC5 DHX9 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CDC42 LIFR CD44 PPP2CA PPP2CB CAMK2B HNRNPF CAMK2D SRC CAMK2A CASP1 OPRM1 EIF2AK3 CAMK2G CENPS IFNG UBE2E1 MCL1 CD86 PTK2B UBE2D1 CD80 VEGFA CDK1 IL22 POMC CXCL1 NFKB2 CSK JAK2 HNRNPA2B1 ILF3 IL2RG MMP9 FBXW11 THOC5 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B HSPA5 CCL3L3 CCR5 RAF1 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 YBX1 PRKRA TARBP2 IFNAR1 P4HB PRTN3 TIMP1 POU2F1 PLCG2 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FLNA FN1 BRWD1 BLNK GRAP2 HLA-DQA2 BTRC S1PR1 HLA-DQA1 JAK3 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCN2 STAT2 MMP3 UBE2L6 HERC5 IL23R IL13RA2 IL13RA1 HLA-H IL4R IL23A CDKN1A FSCN1 HLA-B NDN HLA-C LIF NANOG HLA-F HLA-G IGHE HLA-E OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 EIF2S2 ATF2 STX3 EIF2S1 IL10RB EIF2S3 CLCF1 EGR1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C EIF4E IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 GBP5 IL11 PIM1 IL19 IL16 DUS2 PGGT1B IL17RE GBP2 OSMR GBP4 PSMD8 IL17RB GBP3 PSMD6 HMOX1 IL31 SLA IL17C SLA2 PSMD7 IL11RA SOCS2 IL7 PSMD2 SOCS6 IL7R SH2B3 IFNL2 PSMD3 IFNL1 AKT1 IRF7 IFNL3 PSMD1 PSMB8 NUP214 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A FAAP100 UBE2V1 FAAP24 HSPA8 VAMP2 CUL5 ICAM1 TNFSF13 FAAP20 FANCM ADRM1 UBA7 FANCL MAPK14 FANCA MAPK11 PSMC5 FANCB PSMC6 FANCE PSMC3 FANCG PSMC4 FANCF PSMC1 PSMC2 ABL2 HSPA1A EIF4G1 PAK2 RAG2 RAG1 IL32 CASP3 FURIN UBA3 IL34 IL1RL1 GAB3 IL33 TGFB1 UBE2M FCGR1BP LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 B2M RELB IRF3 MAP3K14 HLA-A RNF7 TRIM21 GBP6 RORC RORA TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A FCGR1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 CENPX TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 HSP90AA1 NEDD4 TNFSF4 LTA CBL CD27 TNFSF9 PLCG1 TNFRSF25 TNFSF8 CDKN1B PDE12 OASL OAS1 FNTB OAS3 RNASEL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 EIF4A2 EIF4A1 MAP2K1 HSP90B1 H3C15 NCAM1 STAT3 NFKB1 ITGAX PIN1 FASLG TNFRSF18 PRL IFITM1 PIAS1 SNCA IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 ABCE1 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 AKT3 TRIM8 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CUBN CBLIF AMN HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) ABL1 RAD52 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 RAD50 RAD51 RPA3 RAD17 RAD1 ATM ERCC4 DNA2 ERCC1 RAD9B RHNO1 ATR RAD9A TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins PRKCSH UBA52 GANAB ST6GALNAC3 ST6GALNAC4 MGAT1 GALNT1 MOGS UBB UBC ST3GAL4 CANX RPS27A ST3GAL1 ST3GAL2 UBE2I ST3GAL3 SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 PARP14 PARP8 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle TFRC KIF14 KIDINS220 DSG1 NUDC VANGL1 ARHGAP1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 PLXND1 PRAG1 TXNL1 ALDH3A2 PKP4 ANKRD26 LEMD3 DEPDC1B RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 BLTP3B TNFAIP1 RND2 PTPN13 NISCH GOLGA3 KTN1 CKAP4 FNBP1 KCTD13 FRS2 SCRIB VANGL2 LRRC1 CAV1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 NECTIN2 CADM3 CADM1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation PLK3 PIN1 CDK2 PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 PRKAG2 PRKAG3 NOC2L STK11 TAF7L CDK5 PRKAB2 TP53INP1 MDM2 PRKAB1 MDM4 TAF4B DYRK2 TBP UBA52 TAF9 TAF1L AURKA TAF15 HIPK1 TAF12 BLM TAF13 MRE11 MAPKAPK5 HIPK2 BRCA1 TAF11 WRN BRIP1 TAF8 KAT5 TAF7 EXO1 CHEK1 TAF6 RBBP8 TAF5 NBN UBB TAF4 TOPBP1 TAF3 SUPT16H ATRIP TAF2 BARD1 TAF1 RFC5 UBC RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TAF10 TP53RK TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CHEK2 CSNK2A2 TAF9B RAD50 CSNK2B RPA3 RAD17 CCNA2 TP53 RAD1 CCNA1 ATM DNA2 NUAK1 RAD9B RHNO1 ATR RAD9A TPX2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 ATP6V0D1 TFRC HFE ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 TF TCIRG1 STEAP3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 MCOLN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols RXRA CYP51A1 NCOA2 CYP19A1 POMC ARNT2 CYP7B1 CYP11A1 NCOA1 CYP7A1 CYP1B1 CYP27A1 CYP39A1 CYP11B2 CYP11B1 ARNT CYP21A2 AHRR FDXR CYP8B1 NR1H4 CYP46A1 CYP4V2 FDX1 FDX2 AHR RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 TAX1BP3 RHPN2 RTKN RHOC LIN7B ROPN1 RHOA RHOB DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription KLF4 SP1 TFAP2A ZEB2 FOXP2 FOXJ2 STRAP KLF9 ARID1A FOXA2 RB1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 IL25 TAB1 IL17RE IL17RB IL17C IL17RC IL17RA IL17F IL17A MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts RXRA OSBP NCOA2 AMACR SLC27A2 SLC27A5 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 NCOA1 CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 OSBPL1A ABCB11 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 ESPL1 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A PTTG1 KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMD8 CENPI PSMD6 TAOK1 CENPK PSMD7 CENPL XPO1 CENPM PSMD2 CENPN B9D2 PSMD3 CENPO CENPP PSMD1 CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PSMA5 PLK1 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CLIP1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling ITGA3 LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 SRC LAMB1 LAMC2 LAMC1 ITGA2 MET HGF PTK2 ITGB1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation SOX17 TBX6 POU3F1 YAP1 POU5F1 PAX6 MAMLD1 FOXC2 CXCR4 FOXC1 IHH PAX2 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD4 GSC SMAD3 MIXL1 PAX3 ZNF521 FOXA2 FGFR1 MAML2 DLX5 MAML1 FGF2 FGF4 MYB EP300 SOX2 GATA6 TBXT EOMES MAML3 NOTCH1 BMP4 TCF7L2 TCF7L1 NANOG LEF1 TCF7 ZIC1 CTNNB1 RBPJ TFAP2A TFAP2B CDH1 SNW1 TFAP2C EPHA4 TEAD2 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TBPL2 GATA4 MSX1 PSMA5 OSR1 PSMA6 PSMA3 ZIC2 PSMA4 PSMA1 TRIM33 PSMA2 PAX8 PAX7 PSMD12 PSMD11 NOG PSMD14 NOTO FOXH1 PSMD13 FOXF1 WNT3A PSMA7 PSMB6 SHH ZEB2 PSMB7 SNAI1 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP PSMB1 KAT2B KAT2A LFNG ADRM1 LHX1 PSMC5 PSMC6 SEM1 DLL1 PSMC3 PSMC4 PSMC1 FOXA1 PSMC2 FGF8 SOX1 GBX2 OTX2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation CLTC CLTA AP2A1 AP2A2 KIF5C AP2M1 KIFAP3 KLC1 KLC4 KLC3 KLC2 IFI30 SAR1B KIF3A KIF3B AP2S1 AP1G1 AP1S2 KIF3C SEC23A AP1S1 KIF5B AP1S3 KIF5A AP1M2 KIF4B AP1M1 AP2B1 HLA-DOA AP1B1 KIF4A HLA-DOB LAG3 KIF11 CTSO CTSF CTSE HLA-DMA HLA-DMB KIF15 RILP CD74 SEC24B SEC24A KIF22 SEC13 HLA-DQA2 SEC24D HLA-DQA1 HLA-DPA1 HLA-DRB5 SEC24C HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 DYNC1LI1 CAPZB DYNC1LI2 KIF26A CTSD KIF23 KIF20A KIF18A DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A ACTR1B CTSH CTSC KIF2C KIF2B CAPZA3 DNM1 CAPZA2 DNM2 DYNC1I2 LGMN ACTR10 SEC31A CANX DYNC1I1 DYNC1H1 CTSS CENPE DNM3 SPTBN2 ACTR1A ARF1 OSBPL1A RAB7A SH3GL2 DCTN2 CAPZA1 DCTN3 CTSA RACGAP1 CTSB CTSV CTSL CTSK ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A8 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 PTEN AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol PLCB4 INPP5D PLCG1 PLD4 OCRL INPP5B SYNJ1 PLCZ1 INPP5J PLCE1 ITPK1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC25A5 SLC28A3 SLC25A4 SLC25A6 ARL2 ARL2BP SLC29A4 SLC28A2 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation DOHH EIF5A DHPS EIF5A2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 ACADS HADH CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A COPS3 COPS6 COPS5 COPS8 CHMP3 CHMP6 CHMP7 PLA2G6 DCTN6 DCTN5 DCTN1 GJC1 DCTN4 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 MAN2A1 GJA9 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CHM TMED2 CD59 DNM3 CD55 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 COG8 COG7 COG6 COG5 COG4 COG3 RAB27B COG2 COG1 RINT1 RAB30 RAB36 TF KIF16B SAR1B KDELR2 KIF20B COPB2 COPA TMED10 ARL1 AP2S1 KIF3B AGTR1 MAN2A2 VTI1A LDLR SERPINA1 KIF3C RAB6B RAB39A KIF18B KIF4B AP2B1 ALPP KIF4A COPE KIF12 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 MAN1A2 F5 KIF13B F8 TMED3 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 STX4 KIF6 BET1L KIF27 COPZ1 SH3KBP1 SLC2A8 RAB33B KIF9 KIFC2 KIFC1 CD3G NAA35 CD3D NAA38 VAMP4 PAFAH1B3 ARF5 NAPA NAPB NBAS CHRM2 TMF1 STX16 STX18 GOSR1 GOLGA2 NAPG STX10 CYTH3 ARFRP1 CYTH2 CYTH4 CUX1 VPS51 CD4 VPS53 VPS52 MAN1C1 BNIP1 STX6 VPS54 CYTH1 RIC1 MYO1C GALNT2 ARCN1 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 SNX2 FNBP1L SNX9 SNX5 TBC1D8B PUM1 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 KIF20A TMEM115 CNIH2 CNIH3 MCFD2 MIA2 PPP6R1 TRAPPC6A FTH1 TRAPPC6B SEC22A SEC22C FTL STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF PLIN3 GGA2 GGA1 GGA3 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 TGFA EREG BTC EPGN AKT3 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria AUH DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM MMAA MMUT SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAH YWHAZ SFN SP1 SMAD4 SMAD3 EP300 UBE2I YWHAB PSMC6 YWHAE PDPK1 YWHAQ CAV1 YWHAG FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation FGFBP3 FGFBP1 FGFBP2 FGF1 FGF10 FGF2 FGF3 FGF22 FGF7 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 FRS3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 PIK3C2A MTMR9 MTMR4 MTM1 PIK3R4 FIG4 MTMR7 PIKFYVE PIK3C3 VAC14 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium UNC119B ARL3 CYS1 NPHP3 RP2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway TRAF2 TNFSF10 TNFRSF10B UNC5A TNFRSF10A DAPK1 UNC5B DAPK2 DAPK3 FADD CD14 MAGED1 APPL1 FAS FASLG TLR4 RIPK1 TICAM2 DCC TICAM1 LY96 TRADD CASP8 CASP9 CASP3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine MAOA TOMT SLC6A3 COMT REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling XIAP RACK1 STUB1 TRAF1 UBE2L3 TRAF2 UBE2D1 ULK1 MAPKAPK2 FADD USP4 UBA52 BIRC2 USP2 BIRC3 MIB2 CYLD SPPL2B SPPL2A CLIP3 RBCK1 OTUD7B CHUK IKBKG UBB IKBKB RIPK1 UBC RPS27A USP21 SHARPIN TNF TBK1 OTULIN OPTN TAX1BP1 UBE2D2 UBE2D3 TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA AREG EGF EGFR EREG BTC EPGN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin FST FSTL3 INHBB INHBA SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins RANGAP1 UBE2I SUMO1 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOA1 APOE APOC2 APOC3 LIPG ALB CETP ABCG1 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB SESN2 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SEC13 SZT2 SAMTOR SEH1L NPRL2 NPRL3 TCIRG1 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 ATP6V1E1 FNIP2 KICS2 ATP6V1E2 CASTOR1 CASTOR2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 HRAS FGF18 SOS1 FGF1 FGF2 FGF23 FGF4 FGF9 NRAS FGF20 FGF16 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency TCN2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase CEP41 TUBGCP4 CEP43 TUBA1A PRKACA SMC4 SMC2 YWHAE TUBB4B TUBB4A NUP107 EML4 CDCA5 NUP160 NCAPG YWHAG NCAPH NUP85 NUP43 HSP90AA1 NCAPD2 RANBP2 SEC13 NUP133 NUMA1 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 CPAP KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PRKAR2B PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CCP110 CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 TUBG1 HAUS2 HAUS1 MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 CSNK2A1 DCTN3 HAUS8 HAUS7 CSNK2A2 CEP70 CEP72 CEP192 TUBA4A PCNT CSNK2B CEP76 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 NEK7 MZT1 NEDD1 ALMS1 TUBGCP5 CLIP1 TUBGCP6 TUBGCP3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDKN1A POT1 TERF2IP H2AC20 HMGA2 H1-1 H1-0 H1-3 CDK2 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A RB1 CDKN1B HMGA1 MRE11 KAT5 CCNE2 CCNE1 H2AX NBN H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 CCNA2 TP53 CCNA1 H2BC11 ATM HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation GUSB CD44 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HYAL2 HEXB HEXA CHP1 SPAM1 HYAL1 HYAL3 HYAL4 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion F8 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) GGPS1 RXRA SCD CYP51A1 FASN LSS SREBF2 SQLE MTF1 DHCR7 ACACB GPAM NFYA NFYB NFYC TBL1X NCOA1 SAR1B SEC23A TBL1XR1 MBTPS1 SCAP MBTPS2 SEC24B SEC24A NCOA2 NCOA6 RAN INSIG2 SMARCD3 INSIG1 SEC24D MVD SEC24C CARM1 KPNB1 HELZ2 CREBBP CHD9 SP1 ACACA MED1 TGS1 IDI1 ELOVL6 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses C4A CLEC5A C4BPA C4BPB CDC73 EXOC1 HSP90AA1 SKIC8 DDX3X HSP90AB1 CTR9 CLU RTF1 VTN APOA1 LEO1 PAF1 IFIH1 C4B_2 CGAS RBM10 STAT2 STING1 MAVS UBR4 C1QA C1S MBL2 TRIM25 IKBKE PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 PAX4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI TRPC7 TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport TTPA RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H HDAC1 POLR2K POLR2L MTA2 GTF2H1 ERCC6 GTF2H2 GTF2H3 RBBP4 MTA1 GTF2H4 MBD3 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 RRN3 ERCC2 MNAT1 EHMT2 GATAD2B GATAD2A CHD3 KAT2B KAT2A HDAC2 UBTF POLR1A POLR1B CHD4 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism GNG13 CGA GNB1 TCF7L2 GNB3 KIF5C INS CTSZ SLC30A8 PCSK1 GNAT3 GPR119 SLC30A5 PAX6 CPB2 ISL1 GIP CTSG FSHB DPP4 CTNNB1 INHBB IGF1 SPCS3 INHBA SPCS2 SPCS1 INHA FFAR1 INHBC SEC11A INHBE SEC11C ACHE LHB ACE2 STX1A KIF5B KIF5A P4HB BCHE PCSK2 ERO1B CGB8 CPA3 MME CDX2 ENPEP AGT LEP EXOC8 CPB1 FFAR4 EXOC7 CLTRN ACE UCN CES1 CPE GATA4 MBOAT4 REN PLA2G7 CRHR2 GH1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GRP TSHB CMA1 GCG POMC ATP6AP2 KLF4 MYO5A RAB27A VAMP2 MYRIP CTSD ANPEP GZMH PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism PAH ASRGL1 KYAT1 QDPR IL4I1 PCBD1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription RUNX3 SMAD4 SMAD3 TP53 CDKN1A ZFHX3 TGFB1 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 CLTC RPS6KA1 CLTA AP2A1 AP2A2 AP2M1 RDX MAPK1 NUMB DNM1 DNM2 MSN AP2S1 SH3GL2 RPS6KA4 KIF4B AP2B1 KIF4A SHTN1 DNM3 RPS6KA6 EZR RPS6KA3 RPS6KA5 L1CAM DPYSL2 RPS6KA2 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins HERC2 XRCC4 PARP1 CDKN2A RAD52 MDC1 SP100 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 PIAS4 NSMCE3 NSMCE2 NUP88 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 CETN2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 BLM BRCA1 NUP37 WRN PML RPA1 SMC1A XPC SMC3 STAG1 STAG2 RAD21 TDG SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions SLCO4A1 SLCO2B1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A1 SLC25A10 SLC13A2 SLC22A12 SLC13A3 SLCO1C1 SLC5A12 SLC16A7 SLCO1A2 SLC16A8 EMB SLC13A5 SLC16A3 SLC17A5 SLC16A1 AVP SLC22A7 SLC22A6 SLC22A8 SLC10A6 SLC5A8 SLCO4C1 BSG SLC44A5 SLC44A3 SLC22A11 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLCO2A1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 CRY2 CRY1 ADRM1 FBXL21P PSMC5 PSMC6 PER2 SEM1 PSMC3 PER1 PSMC4 PER3 PSMC1 PSMC2 SKP1 CUL1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland PRL FGF10 TGFA AREG EGF FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 SGF29 NCOA6 KANSL1 PHF20L1 KANSL2 SETD1B KANSL3 SETD1A RBBP5 KMT2D PHF20 BOD1L1 ASH2L MBIP TASP1 KMT2C DR1 KMT2B BOD1 KAT2B KAT2A YEATS2 AKAP8L MEN1 TADA3 PAGR1 KAT8 OGT HCFC2 WDR82 PAXIP1 KDM6A DPY30 KAT14 MCRS1 WDR5 KMT2A PSIP1 ZZZ3 HCFC1 TADA2A DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 GALM CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane F8 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis PCSK1 CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE POMC RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants HRAS NRAS KRAS MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development RPS6KA1 EDNRB ASAH1 DICER1 TRPM1 PAX3 YWHAE SNAI2 TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 PXN SMARCD1 SMARCD2 SMARCD3 RARS1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 SMARCE1 MC4R DARS1 EEF1E1 LIG1 MC3R KARS1 GMPR IARS1 EP300 MC5R SOX2 AKT2 ATP6V1E1 SOX9 ATP6V1G1 ATP6V0B ATP6V0E1 KIT DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H ZIC1 FOXD3 MAPK1 TBX2 HINT1 TFE3 CCND1 MITF ITGA2 SIN3A TFEC ALX3 CDK2 TBX3 CTNNB1 MET ATP6V1C1 GPR143 MAPK3 EPRS1 TNRC6C MOV10 ID1 TFAP2A AGO3 STT3B AGO4 CDH1 UBE2I AGO1 AGO2 DPF1 SUMO1 TNRC6A TNRC6B DPF2 YWHAB DPF3 XPO1 SS18L1 ARID1A GSK3B ARID1B YWHAZ PPARGC1A PLK1 SS18 SMARCB1 CCNB1 POMC WNT3A SOX10 SMARCC1 BRCA1 SMARCC2 MARK3 ACTB ACTL6A CREBBP GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TFEB TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 AKT3 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK2 PANK3 PANK1 DCAKD DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex FRAT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 TCF7L1 HDAC1 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 PPP2CA PPP2CB PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 TLE5 APC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CTBP2 CTBP1 PSMB5 PPP2R1B UBB PPP2R1A PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TLE3 SKP1 CUL1 FRAT1 PPP2R5E MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling CRK ARF6 RAB4A RAB4B MET GAB1 GGA3 HGF CRKL IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA PPIA PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation SMAD2 SMAD4 GSC SMAD3 MIXL1 TRIM33 BMP4 POU5F1 SOX2 TBXT NANOG LEF1 TCF7 EOMES FOXH1 CTNNB1 TBPL2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot PLAT SERPINE1 SERPINB8 SERPINB6 S100A10 PLAU PLAUR SERPINE2 SERPINF2 SERPINB2 PLG ANXA2 HRG PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi ST3GAL4 TMED2 SEL1L RFNG MFNG B4GALT1 FURIN LFNG ST3GAL6 ST3GAL3 ATP2A3 RAB6A ATP2A2 ATP2A1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo YAP1 TJP2 WWC1 STK4 SAV1 WWTR1 STK3 MOB1B YWHAB LATS1 MOB1A LATS2 DVL2 AMOTL2 AMOTL1 YWHAE TJP1 NPHP4 CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA AREG EGF PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK2 CDK4 CCNE1 CDKN1B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) IDH3B CS ISCA2 IDH3A MDH2 ISCA1 ACO2 ACAT1 LYRM4 SUCLG2 KGD4 SUCLG1 CSKMT SDHC TRAP1 SDHD SDHA SDHB OGDH FXN NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH IDH2 SIRT3 DLST IDH3G DLD INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling STAT5A STAT5B UBE2D1 LYN STAT3 UBA52 JAK2 JAK1 STAT1 SOCS1 UBB CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins AQP1 GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 RAB11A PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 AVP GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A RAB11FIP2 MYO5B GNG10 AQP4 AQP2 GNG12 AQP3 GNG11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling NTRK1 CLTC AP2S1 CLTA AP2A1 AP2A2 SH3GL2 NGF AP2B1 AP2M1 DNAL4 DNM3 DNM1 DNM2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation MMP15 COL18A1 COL17A1 MMP19 COL15A1 COL16A1 TMPRSS6 COL13A1 COL14A1 FURIN COL12A1 COL19A1 ELANE COL26A1 COL25A1 COL23A1 ADAM10 ADAM9 PRSS2 MMP8 MMP9 COL9A1 MMP1 COL9A3 MMP2 COL9A2 ADAM17 PHYKPL CTSD MMP3 CTSB MMP20 CTSL MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation IKBKB TASL CHUK IRF5 SLC15A4 IKBKG TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling GNG13 ITGA5 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 SRC GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNAI3 GNAI1 GNAI2 GNG10 ITGB1 GNG12 GPER1 GNG11 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation TRAF2 RELA NFKB1 TRAF6 NFKB2 CHUK IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG IKBKB NFKBIA AGER MAVS RNF135 S100A12 MAP3K1 RIGI APP S100B SAA1 HMGB1 NFKBIB TRIM25 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE NPL NEU2 NEU3 NEU4 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA ST6GALNAC1 CMAS SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 NANP ST8SIA3 NANS GLB1 ST6GAL1 ST6GAL2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL PGM1 GYG1 PYGM PHKG1 PHKG2 GYG2 AKR1E2 AGL PHKA1 PHKB PHKA2 GAA CALM1 PYGB METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins ACE2 CMA1 CTSZ CTSD CPB2 CTSG CPA3 MME ANPEP ENPEP AGT CPB1 GZMH ATP6AP2 ACE CES1 REN REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 VCP TMPRSS2 CTSL HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation CREBBP RPTOR MLST8 HSP90AA1 HSPA8 EP300 CAMK2B CAMK2D HSPB8 HSP90AB1 CAMK2A MTOR DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A CRYAB AKT1S1 FKBP4 HSPA1B CAMK2G INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling STAT5A STAT5B STAT3 PIK3R2 PIK3R1 BRWD1 JAK3 JAK1 CISH TSLP IL2RG SOCS1 IRS1 IRS2 CRLF2 H3C8 SMARCA4 SOCS2 IL7 IL7R RAG2 RAG1 HGF PIK3R3 H3C15 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 FURIN HSPA8 CSNK2A1 HSP90AB1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RXRA CYCS HDAC3 NR1D1 TBL1X NCOA1 ESRRA ATF2 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 TWNK SSBP1 HCFC1 CALM1 PPARGC1A NCOA2 PPARGC1B NCOA6 SMARCD3 NRF1 GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HELZ2 CREBBP CHD9 ALAS1 MTERF1 GABPA MED1 SIRT5 TGS1 PPRC1 MEF2D PERM1 CAMK4 IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 PPARA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK STAT3 PIK3R2 PIK3R1 HDAC1 PLCG1 HDAC3 JAK3 SIN3A ALKAL2 ALKAL1 PRDM1 CD274 IL2RG PTPRZ1 IRS1 DNMT1 PIK3CB PTN MYCN MDK EP300 MYC PTPN6 HDAC2 ALK FRS2 HIF1A PIK3CA NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs NEIL3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MT-ND4L GFM1 GFM2 MRRF MT-CYB MTFMT MTRF1 TSFM MTRF1L MTIF2 MTIF3 MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation FCN3 FCN1 COLEC10 MBL2 MASP1 COLEC11 FCN2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism PAH ASRGL1 KYAT1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PCBD1 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia IVD TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host HBA2 HBB REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels ATP2A3 ATP2A2 ATP2A1 ATP2B4 SLC8A1 ATP2B3 SLC8A2 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors PARK7 PPARGC1A PIAS4 NCOA2 DDX5 NPM1 TRIM28 SIN3A NRIP1 HIPK2 DAXX ZNF131 UHRF2 NCOA1 DDX17 CASP8AP2 CTBP1 MBD1 SAFB TOPORS CREBBP MRTFA NCOR2 BMI1 PIAS3 ING2 SUMO3 SUMO2 EP300 RING1 UBE2I PIAS1 SUMO1 RNF2 CBX8 PHC2 PHC1 CBX4 PCGF2 CBX2 PHC3 ZNF350 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system UBC RPS27A TLR2 B2M UBA52 MRC1 UBB ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria E2F1 PMAIP1 TP53 TFDP1 TFDP2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B2 SLC26A2 SLC26A11 SLC26A1 PAPSS2 PAPSS1 SLC35B3 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2E1 CYP2F1 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2S1 CYP2D6 CYP2A7 CYP2A6 CYP2C19 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling TIAM1 LYN ARPC1B ARPC1A KALRN RHOA ROCK1 ROCK2 ARPC4 CFL1 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ARHGEF28 ACTG1 SDC2 ACTB CDC42 ITSN1 RASA1 YES1 PAK1 LIMK2 RAC1 HRAS LIMK1 FYN GRIN2B GRIN1 PTK2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PCNA AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA ELL CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XPA COPS7B COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 PPIE COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 ERCC5 COPS8 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GRIK5 GRIK3 GNG3 GRIK4 GRIK1 GRIK2 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD PLCB3 PLCB1 GNG10 DLG3 PLCB2 DLG4 CALM1 GNG12 GNG11 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LRP1 RETSAT APOA2 APOM APOA1 BCO2 APOA4 BCO1 HSPG2 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 RUNX3 ITGAL CBFB SPP1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS CYP19A1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis CAD DHODH UMPS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence CDKN2D CDKN2C CDKN2B UBA52 CDKN2A RB1 MAPK1 E2F1 E2F2 E2F3 CDK6 TFDP1 MAPK3 TFDP2 ETS1 CDK4 ETS2 UBB UBC SP1 TNRC6C ERF RPS27A MOV10 ID1 AGO3 AGO4 AGO1 MDM2 TNRC6A MDM4 TNRC6B TP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin MAOA ALDH2 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB14 RHOQ KIFAP3 RALGAPA2 RALGAPB RAB13 PRKAA2 KIF3A PRKAG1 PRKAG2 LNPEP PRKAG3 KIF3B PRKAB2 PRKAB1 YWHAB YWHAE C2CD5 EXOC8 EXOC7 AKT1 YWHAQ CALM1 YWHAG ASPSCR1 YWHAH EXOC4 YWHAZ EXOC3 SFN EXOC6 STX4 TBC1D1 EXOC5 SNAP23 TBC1D4 EXOC2 EXOC1 RALA RAB11A RAB4A MYO1C MYO5A VAMP2 AKT2 SLC2A4 RAB8A RAB10 RAC1 MYH9 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly GJB6 GJB5 GJB7 GJC1 GJC2 GJA3 GJA1 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJB2 GJD4 GJB1 GJD3 GJB4 GJB3 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF22 TGFBR3 GIPC1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling CXCL8 CD86 CD80 IL10RA PTAFR CXCL2 STAT3 LIF IL1RN CXCL1 FPR1 CCL3L3 IL1R2 CCR5 CCL5 IL12B IL12A CCL4 IL18 CCL3 JAK1 IL1A CCL2 IL1B CCL19 IL10 CCR2 IL10RB CSF2 CCR1 IL1R1 CSF3 CCL22 TYK2 CCL20 TNFRSF1B FCER2 CXCL10 TNF ICAM1 PTGS2 IL6 TIMP1 TNFRSF1A CSF1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 GP9 VWF GP1BA GP1BB TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct WFDC2 MECOM OSR1 FGF2 GATA3 HOXB4 ID4 BMP4 HOXA6 PAX8 LHX1 PLAC8 CTNNB1 NPNT PAX2 RET EMX2 PCDH19 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 MET GAB1 HGF PTPN11 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle SEL1L PRKCSH UBA52 RNF185 GANAB PDIA3 EDEM2 UBB UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN ITGA2 GXYLT2 CDH2 PXN SERPINE1 STT3B CDH1 SOX2 EDIL3 ZEB1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants FLT3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX12 PEX3 ACBD5 GDAP1 PEX13 PEX14 PXMP2 PXMP4 ABCD2 PEX11B ABCD3 PEX26 ABCD1 PEX2 ATAD1 PEX16 FIS1 PEX19 SLC25A17 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation B4GALT6 B4GALT4 B4GALT5 MGAT4A ST3GAL4 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 B4GALT2 B4GALT3 MGAT5 ST8SIA3 ST6GAL1 MGAT4C OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions TREM2 PLXNA2 ITGA1 SEMA3E SEMA4A CD72 SEMA5A SEMA4D PLXND1 PLXNC1 SEMA6A PLXNA4 SEMA6D PTPRC SEMA7A ITGB1 PLXNA1 TYROBP PLXNB3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry LY6E TIMD4 AP2A1 TYRO3 FURIN AP2A2 MERTK PIK3R1 UBA3 MAPRE3 EMC4 CD14 AP2M1 UBA1 HSPA5 CD33 HSPG2 CLDN1 CD209 SDC4 ATG7 SDC2 SDC3 AP2S1 AXL AGRN GPC1 AP2B1 UBA7 GPC3 HAVCR1 UBA6 GPC2 UBA5 MRC1 GPC5 GPC4 GPC6 RPSA PROS1 SDC1 CD300A GAS6 RNASEK RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 CDK2 LMNB1 MLH1 UBE2I FIGNL1 TEX12 TEX15 MSH4 MSH5 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B MND1 FIRRM REC8 BLM SYCP3 MRE11 BRCA1 BRCA2 STAG3 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 SPO11 H2BC12L H2BC21 SUN2 SUN1 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 SMC1A RAD50 SMC3 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 STAG1 H2BC11 STAG2 ATM RAD21 ATR H3C15 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS PTDSS2 PTDSS1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 CSNK1A1 PARP14 PARP8 UBA52 ST6GALNAC3 ST6GALNAC4 SRPK2 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD ITPR3 WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 PIK3CA VAV1 VAV2 IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 PLD4 V2-19 MAPK1 V1-11 PLD3 V1-16 V1-13 ELMO2 MAPK3 PLD2 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 PRKCD DOCK1 BRK1 LYN BTK CFL1 PLPP5 PLPP4 ACTB MYO5A YES1 HCK SYK PAK1 AHCYL1 FYN NCKAP1L WASF1 PRKCE PTK2 WASF2 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes IFI6 IKBKB IFI44L FKBP5 ARIH1 UBA7 HSPA5 RIGI CHUK ATF6 ISG15 IFIH1 UBE2L6 TRIM25 HERC5 IFI27 EIF2AK3 IKBKG RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors INSL3 INSL5 RXFP4 RXFP1 RLN2 RXFP2 RLN3 RXFP3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PTK6 CDKN1A CCND1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis SLC2A1 B4GALT1 LALBA SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine AMDHD2 GFPT2 GFPT1 PGM3 NAGK GNPNAT1 UAP1 RENBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) MBD4 PCNA SMUG1 PARP1 NEIL2 NEIL1 MPG PNKP LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 OGG1 RFC2 RFC1 PARP2 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLB POLE2 POLE3 PARG NTHL1 APEX1 TDG ADPRS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling HRAS SOS1 HBEGF SHC1 TGFA AREG EGF EGFR NRAS EREG BTC EPGN PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation JUN XIAP RNF146 USP7 MBD3 TNKS GATAD2B GATAD2A PREX2 PTEN CHD4 SNAI2 RCOR1 TRIM27 WWP2 EED NEDD4 MKRN1 FRK HDAC5 USP13 MTA2 HDAC7 RBBP4 MTA1 REST MTA3 RBBP7 TNKS2 PML AKT2 OTUD3 HDAC1 HDAC3 KDM1A MAPK1 MAPK3 ATF2 EGR1 RPTOR TNRC6C MOV10 MLST8 SLC38A9 CHD3 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 HDAC2 TNRC6A TNRC6B MTOR RNF2 PSMD8 RRAGA PSMD6 RRAGC SUZ12 CBX8 PSMD7 PHC2 RHEB RRAGB PHC1 PSMD2 RRAGD NR2E1 CBX4 PSMD3 LAMTOR2 AKT1 CBX2 LAMTOR1 PSMD1 PHC3 LAMTOR4 LAMTOR3 LAMTOR5 MECOM PSMA5 STUB1 PSMA6 PSMA3 PSMA4 ATN1 PSMA1 SALL4 MAF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 SNAI1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 PPARG AKT3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN NOS3 WASL DNM2 CAV1 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes CREBBP MAFK NFE2L2 ABCC3 EP300 ABCF2 ABCC1 ABCG2 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA ASCC2 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBE2D1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 UBB RPS17 RPS15A RPS16 RPS19 UBC RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 ZNF598 RPS24 RPS27 RPS23 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 IPPK ITPK1 IP6K1 NUDT3 NUDT4 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function SOX10 CTNNB1 JUP CDH19 CTNND1 ZC3H12A CTNNA1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ARAP1 UBC PTK6 RPS27A DOK1 CBL AKT1 UBA52 UBB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBIN HSP90AA1 ERBB2 CDC37 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH KGD4 DLST DLD PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing JUN H2BC9 H2AZ2 H4C9 SEL1L H2BC8 H2BC5 H2BC3 FURIN H2BC1 H2AC20 CCND1 ATP2A3 ATP2A2 MAMLD1 ATP2A1 RBPJ TMED2 TNRC6C RFNG MOV10 MFNG B4GALT1 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 ELANE E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 ST3GAL4 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A LFNG EP300 ST3GAL6 H3-3B H3C8 ST3GAL3 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins APBB1IP TLN1 CRK FN1 SRC BCAR1 RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 NTF4 NTRK2 BDNF PLCG1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 GNAS RAB11A AVP PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 CLOCK NPAS2 HELZ2 RAI1 CREBBP CHD9 NCOR1 MEF2C TBL1XR1 EP300 MED1 TGS1 MEF2D RORC RORA RORB SIRT1 PPARA CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNG13 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ABL1 ADCY1 SPP1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PRKACG PRKACA PRKACB STAT1 PECAM1 GNG3 GNG2 NFKBIA GNG5 GNG4 GNG7 GNA11 GNG8 GJA1 NOS3 PRR5 P2RX7 TRPV4 GNAS PKN2 CACNG7 CAPNS1 CAPNS2 CAPN2 RAMP2 PPP2R1B PPP2R1A CALCRL PIK3CB ADM PRKAR1B PRKAR2B PRKAR1A PRKAR2A PDPK1 CACNB2 PIK3CA P2RY2 ITGB3 ITGB1 MAPKAP1 ITGAV ITGA5 CACNA2D1 PIK3R2 NFKB1 PANX1 HSPG2 CTNNB1 CHUK PTPN1 CACNB1 CACNB3 IKBKB PPP2CA MLST8 MTOR IKBKE AKT1 CALM1 FLT4 KDR IKBKG ANXA2 TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD FYN CACNA1H GNG10 PTK2 GNG12 MMP14 GNG11 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 FZR1 SKP2 CCNE2 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 POLD3 POLD4 POLD1 POLE POLD2 RFC1 POLE4 POLE2 POLE3 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes AIM2 BCL2 RELA BCL2L1 NFKB1 HSP90AB1 NLRC4 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 NLRP1 PYCARD NLRP3 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription CREBBP RBPJ MAML2 FABP7 MAML1 KAT2B HEY1 KAT2A HES1 SNW1 EP300 WWC1 HEY2 DLGAP5 HES5 PTCRA PLXND1 PBX1 HEYL MAMLD1 MAML3 STAT1 NOTCH3 NOTCH1 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing ABHD17C FNTA ABHD17B BCL2L1 ABHD17A RCE1 NRAS PDE6D ICMT HRAS FNTB LYPLA1 PRKCQ ARL2 PRKG2 GOLGA7 KRAS USP17L2 CALM1 ZDHHC9 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism SLC26A2 SLC26A11 SLC26A1 PRKACG SLC2A1 PRKACA PRKACB G6PD B4GALT6 B4GALT5 FUT2 FUT1 TKFC B3GALT4 GALM PCK2 SLC37A1 G6PC2 G6PC3 FBP1 FBP2 SLC35B3 B4GAT1 LALBA SLC35B2 XYLT2 SLC35D2 XYLT1 B4GALNT2 B3GALT2 B3GALT1 FAM20B FUT4 FUT6 FUT5 FUT7 FUT9 B3GALT5 CHPF GALK1 PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 GALE CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 GCKR GCK PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 B3GAT3 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU B4GALT1 NDST4 TKT GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE NUP214 UBA52 MAN2B2 MAN2C1 UBB TALDO1 UBC ABCC5 RPS27A GAPDHS PGD PC GBE1 PYGM CEMIP STAB2 GYS2 LYVE1 PHKG1 HAS1 PHKG2 HYAL2 GYG2 HAS3 EPM2A GNS CHP1 AKR1E2 PHKA1 HAS2 SPAM1 PHKB PHKA2 PPP1R3C NHLRC1 GALT PYGB PYGL B3GALT6 SLC37A4 B4GALT7 ABO IDUA NCAN HEXB HEXA BGN AGL GLB1L3 DCN GLB1L2 BCAN NUP205 POM121 VCAN NUP107 GLB1L HYAL1 NUP188 GLB1 AAAS HYAL3 HYAL4 NUP160 POM121C AKR1B1 IDS CSPG5 NUP42 NUP85 CSPG4 TPR GUSB ARSB NUP62 GYG1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 GYS1 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RHCE PPP2R1B RHD PPP2R1A PGM2 PGM1 FUT3 PPP2R5D DERA G6PC1 B3GNT3 CHST14 DCXR AKR1A1 HSPG2 SORD CRYL1 XYLB MANBA GAA PCK1 ACAN LUM CD44 PPP2CA PPP2CB AGRN FMOD HK1 CALM1 GPI ADPGK ENO1 ENO2 ENO3 HK2 ENO4 HK3 TPI1 PGAM1 PGAM2 MAN2B1 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 ST6GALNAC6 PGK2 PFKL GNPDA1 GNPDA2 PFKM DSEL PFKP DSE UST CHST15 GLYCTK ST3GAL4 KHK SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 ST3GAL2 HMMR ST3GAL3 SLC9A1 UGP2 ALDH1A1 PRPS2 PRPS1 RPEL1 RPE CTSL SHPK PGLS PRPS1L1 RBKS SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 NUP107 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG DNMT1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B CHAT PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC18A3 SLC5A7 TSPOAP1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR2 GNPAT DHRS7B AGPS AWAT1 AWAT2 FAR1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport RHBG RHCG RHAG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases GUCY2C NHERF4 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle ARHGAP26 MPP7 VANGL1 ARHGAP32 ARHGEF7 PIK3R2 PIK3R1 RHOJ ARL13B CDC42 CPNE8 STEAP3 WIPF2 FMNL3 FNBP1L GJA1 FNBP1 SCRIB LAMTOR1 TFRC IQGAP3 SNAP23 ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 SYDE1 OPHN1 GIT1 TMPO DOCK8 WASL OCRL DEPDC1B CDC42EP1 VAMP3 RAB7A TRIO WAS NIPSNAP2 SLC1A5 ARHGAP21 PREX1 STOM PAK1 PAK3 CDC42BPB CDC42BPA PAK2 PAK4 DIAPH3 GIT2 CAV1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 POFUT2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 PSIP1 HMGA1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 RAC1 RAP1B RAPGEF1 RAP1A CRK MET GAB1 DOCK7 HGF CRKL DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events PPP2CA PPP2CB PPP1R1B PPP2R5D CDK5 PRKAR1B PRKAR2B PPP3CC PRKAR1A PDE4A PPP1CA PRKAR2A PDE4D PDE4C PPP3CA PRKACG PPP3CB PRKACA PRKACB PPP3R1 CALM1 PPP2R1B PPP2R1A SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling PRKCA SOS1 HBEGF SHC1 EGF ERBB2 EGFR NRAS NRG1 HRAS PRKCE EREG NRG3 NRG4 PTPN12 NRG2 BTC PRKCD MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer CDKN1A RPS6KB2 CDKN1B RICTOR CHUK FOXO4 BAD MLST8 FOXO6 FOXO1 AKT2 TSC2 MDM2 NR4A1 MTOR PRR5 PDPK1 FOXO3 AKT1S1 GSK3A AKT1 CASP9 GSK3B MAPKAP1 AKT3 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones RUVBL1 KANSL1 KANSL2 KANSL3 H2AC1 EP400 KAT7 ATXN7 SUPT20H ATXN7L3 TADA3 ING4 ING3 PAX3 OGT SUPT3H TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 WDR5 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2BC18 DMAP1 MRGBP TAF9 TADA1 VPS72 MSL2 MSL3 MSL1 TAF12 RBBP7 H2AC19 H2BC26 H2AC14 USP22 H2BC21 TAF10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 H2BC9 BRPF1 H4C9 BRPF3 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 ATF2 PHF20 ING5 SAP130 KAT8 TRRAP H2AC17 BRD1 H2AC12 KAT14 MEAF6 ZZZ3 HCFC1 TADA2A SGF29 NCOA2 TADA2B H2AC25 EPC1 H2AC21 KAT5 ACTB CLOCK ACTL6A CREBBP YEATS4 MBIP DR1 KAT2B KAT2A YEATS2 KAT6A MCRS1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation INS GRB10 IRS1 INSR IRS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells HRAS RASGRP3 NRAS RASGRP1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events CXCL6 CXCL9 CXCL8 TAS2R10 CXCL13 TAS2R13 CXCL3 TAS2R14 CXCL2 TAS2R16 ADCY9 CXCL5 CX3CL1 GNAL ADCY4 CXCL16 ADCY3 CCR9 ADCY2 CCR8 ADCY1 CCR7 ADCY8 KNG1 CCR4 ADCY7 CCR3 ADCY6 CCL13 ADCY5 CX3CR1 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCR6 CCL5 PPBP CXCR3 CCL4 RGSL1 OPN3 CCL1 RRH TAS2R40 CCL19 TAS2R41 CCR2 RGR TAS2R43 CCL16 OPN5 PLA2G4A TAS2R46 CCR10 CCL25 CCR1 CCL21 FPR2 CCL20 CXCL10 PDE1B CXCL11 RXFP4 PDE1A CXCL12 ITPR1 GPR17 ITPR2 ACKR3 TAS2R30 ITPR3 TAS2R31 CCL28 RXFP3 CCL27 PSAP TAS2R38 NMS PDYN NMU AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 SSTR3 GPR37 ANXA1 GPR31 PLCB4 GNAS GPR55 MTNR1A TAS2R50 MTNR1B MCHR1 RLN3 LPAR1 LPAR2 LPAR3 LPAR5 PPP3CC MT-RNR2 CHRM2 INSL5 PENK S1PR3 S1PR2 APLN GPR37L1 CHRM4 S1PR5 TAS2R19 S1PR4 PMCH TAS2R42 RGS4 TAS2R45 RGS5 PPY RGS3 RGS1 TAS2R60 CASR OXGR1 GAL MCHR2 NPB NPW NMUR2 NMUR1 NPY2R NPY1R APLNR PRKAR1B SUCNR1 BDKRB2 PRKAR2B HCAR2 BDKRB1 PRKAR1A HCAR3 PRKAR2A PRKX HCAR1 PPP3CA PPP3CB GNAT2 PYY RGS18 TAS2R9 RGS17 PLCB3 RGS19 PLCB1 HEBP1 RGS13 PLCB2 RGS16 P2RY12 GRM3 PPP3R1 P2RY13 P2RY14 GRM2 GRM7 P2RY4 RGS21 ADORA3 GRM6 ADORA1 GPER1 GRM8 NPY5R SSTR1 SSTR2 HRH4 SSTR4 SSTR5 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 HTR1E CNR2 CNR1 HTR1F OPRD1 HTR1D HTR1B ADRA2C HTR5A ADRA2B C5AR1 ADRA2A C5 TAS2R7 PTGDR2 PTGER3 TAS2R8 AGT GRM4 TAS2R1 TAS2R3 PRKCD TAS2R5 PRKCA TAS2R4 PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG GNG10 NBEA GNG12 GNG11 GNG13 GNB2 GNAQ C3 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 OPN1LW GNAZ GNA14 GNG3 CDK5 GNA15 OXER1 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 OPN1MW RGS11 RHO GNAT1 PPP2R1B PPP2R1A PPP2R5D NPY MAPK1 GNAT3 PPP2CA PPP2CB PPP1R1B CXCR1 CCL4L2 CXCR2 RGS8 CAMK2B PCP2 CAMK2D SRC GPSM1 GPSM2 CAMK2A PDE4A GPSM3 PDE4D PDE4C GNAI3 RGS14 RGS20 GNAI1 RGS22 RGS10 GNAI2 RGS12 OPRM1 SST CALM1 CAMK2G OPN1SW GABBR2 GABBR1 OPRK1 POMC CXCL1 PPP1CA TAS2R20 CAMK4 APP SAA1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 BDH2 BDH1 HMGCL HMGCS2 HMGCLL1 AACS ACAT1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 LYN PLCG2 PLCG1 EPO EPOR IRS2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain F8 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MTA2 ERCC6 RBBP4 MTA1 MBD3 MTA3 TTF1 RBBP7 H2AX EHMT2 GATAD2B GATAD2A H2AB1 H2AC19 H2BC26 H2AC14 CHD3 H2BC12L H2BC21 CBX3 H3-3B H3C8 HDAC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CHD4 H3C15 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD HNMT MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 HSPE1 HSPD1 ESR1 LONP1 CAT NRF1 DEFA5 HSF1 DNAJA1 HSPA1A SOD2 SIRT3 FOXO3 AKT1 HSPA9 HSPA1B HTRA2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH ADHFE1 D2HGDH NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown NUP85 PRKCA TPR NUP62 BANF1 PLK1 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 VRK1 CDK1 NUP153 LEMD2 NUP93 NUP50 NUP35 EMD NUP54 LMNB1 NUP37 LEMD3 CNEP1R1 LPIN1 LPIN2 LPIN3 PRKCB NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 S PHASE%REACTOME%R-HSA-69242.5 S Phase ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 CDCA5 RB1 CDKN1B FZR1 E2F1 RBBP4 SKP2 CABLES1 ESCO1 ESCO2 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 CKS1B MAX POLD3 POLD4 POLD1 POLE POLD2 RFC1 AKT2 PDS5B SMC1A SMC3 PDS5A WAPL POLE4 STAG1 STAG2 RAD21 POLE2 POLE3 PTK6 CDKN1A CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B RBL2 ANAPC15 ANAPC16 ANAPC7 CCNH UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones ATP6V0D1 SRPRB TPP1 PREB CXXC1 HDGF PPP2R5B KDELR3 SHC1 ADD1 DCTN1 HSPA5 SEC31A ERN1 EXTL2 PLA2G4B EXTL3 HYOU1 GSK3A ACADVL PDIA6 DNAJB11 SERP1 WFS1 TLN1 DNAJC3 CUL7 FKBP14 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 CTDSP2 SRPRA MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 TSFM MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 GFM1 MRPS17 MRPS15 MRPS16 MRPS14 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PHF20 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 MDM2 PSMC5 MDM4 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 GNE CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) FZD2 GNG13 FZD5 FZD7 WNT5A FZD4 GNB2 WNT16 FZD6 GNB1 WNT1 FZD1 GNB4 FZD8 GNB3 PTHLH GNB5 GNGT1 GNGT2 GIP IHH SMO PTCH1 GNG3 FZD10 GNG2 GNG5 GNG4 GNG7 CRHBP ADCYAP1 GNG8 ADCYAP1R1 CD55 WNT10A FZD9 UCN PTH1R UCN3 UCN2 PTH2R WNT7B GNAS CRH WNT7A GCGR GCG PTH2 WNT3A ADGRE5 ADGRE3 WNT9A GLP1R SHH VIPR1 DHH VIPR2 CRHR1 SCT WNT3 RAMP2 GIPR CALCA GHRHR GLP2R RAMP3 WNT8A CALCB WNT8B SCTR CALCR GHRH CALCRL VIP ADM2 ADM IAPP RAMP1 PTH WNT10B WNT9B WNT6 WNT4 WNT2 PTCH2 WNT2B ADGRE1 GNG10 ADGRE2 WNT11 GNG12 FZD3 GNG11 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic STX5 BET1L GOLIM4 RAB33B RAB41 GOLGA5 ARF1 NAPA NAPB COG8 COG7 COG6 STX16 NSF COG5 MAN2A1 COG4 GOSR1 COG3 NAPG COG2 COG1 CYTH3 RAB30 CYTH2 RAB36 CYTH4 CUX1 MAN1C1 SNAP29 STX6 MAN2A2 VTI1A CYTH1 RIC1 RAB39A RGP1 ALPP TRIP11 GOSR2 MAN1A2 VPS45 YKT6 MAN1A1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation B3GNT5 B4GALT6 B4GALT5 MMRN1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ADAMTS13 GALNT10 GALNT9 POMT2 GALNT8 B3GALNT2 B3GNT9 QTGAL SLC35A4 B3GNT8 FKRP CRPPA B3GNT6 GALNT1 POMT1 CHST4 POMGNT2 GCNT1 POMGNT1 GCNT3 B4GAT1 GCNT4 MGAT5B GCNT7 CHST10 GALNT7 GALNT6 POMK DAG1 GALNT5 RXYLT1 GALNT4 LARGE1 A4GNT LARGE2 GALNTL5 GALNTL6 FKTN GALNT2 POFUT2 B3GNT7 B3GNT4 B3GNT2 POFUT4 POFUT3 EMID1 MMRN2 MUC13 B3GNT3 GALNT12 SEMA5A SPON2 SEMA5B SPON1 ST6GALNAC2 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 ST6GAL1 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ST6GALNAC3 ADAMTS14 ST6GALNAC4 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification NR5A1 PCNA SEL1L RELA CP NPM1 RNF185 NR3C1 SP100 DERL1 DERL2 RNF5 RAB9A RAB9B OS9 VDR ARF4 IL6 SENP5 SENP2 NOP58 CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 SHISA5 PDIA6 MXRA8 SPARCL1 AURKA SCG2 GBF1 TGOLN2 STC2 PENK RAB11A IGFBP7 NDUFAB1 AMELX POMT2 WFS1 B3GALNT2 AMBN ZNF131 TMEM132A SLC35A4 FUCA2 UHRF2 FKRP HRC CRPPA DDX17 CASP8AP2 POMT1 MELTF MBD1 SERPINA10 POMGNT2 MIA3 SAFB POMGNT1 B4GAT1 MSLN TOPORS PRSS23 MGAT5B CHRDL1 CHST10 BMP15 POMK DAG1 RXYLT1 LARGE1 MEPE LARGE2 DNAJC3 B4GALNT2 RCN1 FKTN PIAS3 VGF ENAM AMTN VWA1 FAM20C FAM20A DDB1 MFGE8 UBE2V2 ITIH2 COPS7B SERPINC1 XPC AFP COPS7A FSTL1 FSTL3 CST3 APOL1 CUL4A TOP2B TOP1 SERPIND1 COPS3 GOLM1 POFUT2 COPS6 COPS5 NUCB1 NOTUM UBE2N POFUT4 COPS8 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGO DCTN6 PIGN DCTN5 PIGP DCTN1 PIGZ DCTN4 PIGW NR3C2 PIGV PIGY PIGX LRRC49 PIGC PIGB CAPZA3 PIGA PIGM PIGL CAPZA2 PIGG PIGF ACTR10 PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 SQSTM1 TTLL1 CHM TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H TFAP2B ING2 SPRN SPACA4 TFAP2C NICN1 UBE2I MDGA2 SUMO1 RECK MDGA1 NRN1 ART3 UBE2D2 ART4 UBE2D3 NTNG1 NTNG2 HIF3A RAB22A CD59 CD52 CD55 ELOB PRND ELOC RBX1 CNTN5 ALPL EPAS1 CNTN3 CNTN4 CUL2 ALPG HIF1A TEX101 VHL RAB40A RAB40B ZNF350 RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 ACTB PTP4A2 DCAF7 RTN4RL1 TTL TUBB6 RAB20 TUBB3 RAB25 TUBB1 RAB26 FBXO4 SVBP RAB23 FBXO6 RAB29 RAB15 RAB19 RAB17 FBXW4 TTLL10 FBXW5 NFU1 FBXW10 TTLL13 MEN1 TTLL11 FBXW7 TTLL12 FBXW9 IGFBP1 UMOD LIAS OTOA FBXW2 RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C TP53 LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FBXL3 EIF5A FBXL5 DHPS FN3KRP EIF5A2 TUBA1C FN3K TUBA1B ICMT DOHH TUBA1A TUBB2B FUCA1 TUBB2A USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 WDR5 RAB3D AAAS NUP160 POM121C NUP42 RAB44 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB31 NUP155 RAB37 NUP133 NUP210 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 HDAC7 NUP54 RAB6A TRAPPC1 RBBP5 RAB4B NUP37 RBBP7 CDC20 FCGR3B MRTFA PML DYNC1LI1 DYNC1LI2 RAB24 CDCA8 RAB10 RAB18 COMMD9 DYNLL1 PARP1 BST1 RANGAP1 VNN1 DYNLL2 CTSZ RHOA INCENP BIRC5 CTSC PRMT3 DYNC1I2 COMMD3 AURKB KCTD6 DYNC1I1 DYNC1H1 NR4A2 THRB TFG COPB1 NR2C1 THBS1 GOLGB1 NFKB2 FGA PLAUR FGG CAND1 ANK1 F7 F9 PROC F10 GGCX SKP1 CCNA2 PROS1 PROZ CCNA1 F2 GAS6 CUL1 DBT PCSK9 APOA2 APOA1 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB LAMB2 FN1 LAMB1 LAMC1 BTRC ADAMTS13 MTA1 RPS2 RPS6 EEF1A1 B4GALT2 B4GALT3 LRR1 CCNF B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B CDC34 PSME1 UBE2J2 SEC31A FBXL8 CALR FBXL4 LRRC41 GAN RRAGA SOCS2 SOCS6 KLHL2 KLHL3 IKBKE UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 CETN2 ACTR1A FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 CSNK1D FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 DCTN2 CUL7 CUL5 UBA6 DCTN3 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F YKT6 UBE2H KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W JMJD6 UBA3 RIOX2 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A ANO8 RNF168 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ANKRD28 ASPH ASB9 ASB6 ASB7 PPP6C PPP6R3 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 TP53BP1 GALNT1 ARFGAP3 ARFGAP2 COP1 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SMC1A SEC31B SMC3 TRAPPC2 SEC16B TRAPPC3 TPST2 KTN1 SEC16A STAG1 TPST1 TRAPPC5 TRAPPC9 STAG2 RAD21 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 TDG CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RAD52 RPL8 DCAF13 MATN3 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 HDAC4 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 AMER1 RPL27A AXIN1 APC CDC73 NCOA2 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PNPLA2 CTBP1 RWDD3 UBA2 DNMT1 SAE1 CREBBP AREG NFE2L2 DNMT3B TGFA DNMT3A EIF2AK2 STS MGAT3 ETF1 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG APOB ARSD UBE2L3 USO1 TUBB8 RAB2A TUBB8B SPTAN1 RAB1A RAB1B HGS RAB5A TOP2A GORASP1 UBE2T OTULIN FDX1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 FUT8 MITF GANAB ADAM10 MAN2A1 MGAT5 MGAT1 FBXL18 FBXL7 MGAT2 OST4 EDEM2 ARF3 MOGS DDOST SDC2 MGAT4C TMEM258 DAD1 OSTC MGAT4A TMED2 CANX MGAT4B STT3A STT3B MAN1B1 GPC3 TRRAP CCP110 KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR DCAF8 RNF128 DCAF5 VDAC3 DCAF4 VDAC2 PIAS4 DCAF6 VDAC1 WSB2 CFTR GATA3 OBSL1 BRCC3 DCUN1D5 SNX3 DCUN1D3 RHOT1 DCUN1D4 RCE1 DCUN1D1 DCUN1D2 ZRANB1 COMMD8 SIAH2 INO80 PUM2 ARF1 NPLOC4 STAM DDA1 TADA2B CYLD ANKRD9 H2AC25 UBXN7 COMMD2 H2AC21 COMMD1 BAP1 COMMD6 WDR48 OTUD7A COMMD7 OTUD7B COMMD4 BABAM1 COMMD5 RAB4A SPSB3 IFIH1 CCDC8 BABAM2 CISH UCHL1 TRIM4 CUL9 UIMC1 DPP3 UFD1 UBD IKBKG NAE1 SOCS5 TOMM70 RIPK2 WDTC1 ACTL6A CCDC22 JOSD2 COMMD10 TULP4 UCHL3 JOSD1 DCAF16 DCAF17 UCHL5 DDB2 FEM1C KAT2B DCAF10 KAT2A DCAF11 PTRH2 FEM1A FEM1B PRKN CAPZA1 WDR20 NEURL2 PSME2 NEDD8 ERCC8 USP17L21 USP17L20 GOSR2 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 USP17L12 ARFGAP1 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 PREB OTUD5 TOMM20 YY1 KDELR3 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS RWDD1 JMJD4 ADRB2 KDM8 FOXO4 VCPIP1 JMJD7 ATXN3 RIOX1 ATXN7 OGFOD1 DRG1 NLRP3 DRG2 RIPK1 RCCD1 SUDS3 CLSPN ZC3H15 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 STX5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 USP26 CAPZB USP20 USP21 RAB32 USP22 TAF10 RAB35 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 SCFD1 SPTBN1 RAB39B PARK7 MUC13 RAB8B INS RAB33A RAB7B FGF23 RAB21 CHML RAB11B RAB12 RAB13 ALPI GRIA1 HNRNPK CKAP4 SENP1 CALM1 UBE2C UBE2E1 UBE2D1 UBE2S CDK1 DLAT BLM PIGS BRCA1 PIGU PGAP1 PIGT WRN GPAA1 PIGK BARD1 CDH2 METTL21A KIN FBXW11 METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT RPA1 EEF1AKMT2 EEF1AKMT1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 DDX5 RAB41 KNG1 COG8 COG7 COG6 COG5 COG4 RAB27B COG3 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG MAN1A2 F5 F8 TMED3 MMRN1 MAN1A1 TMED7 TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B U2AF2 GALNT11 ARF5 GALNT14 NAPA GALNT13 NAPB GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GOSR1 NAPG GALNT8 GOLGA2 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 BPIFB2 GCNT1 GCNT3 GCNT4 GCNT7 MAN1C1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNT2 GALNTL6 ARCN1 COPG2 COPG1 LTBP1 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A COL7A1 MDC1 SPTB B4GALT1 DTL MYC ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 PSMD3 PSMD1 SPTBN2 NUP214 PSMD9 PSMD4 PSMA5 PSMD5 PPARGC1A PSMA6 PSMA3 PAAF1 PSME3 PSMA4 PSME4 PSMA1 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 UBA52 PSMG3 PSMG4 PSMD12 PSMG1 PSMD11 PSMG2 PSMD14 PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FOXL2 PSMC2 HIC1 SP3 PPARG PPARA LY6E PEX10 SRD5A3 PEX12 C3 PEX13 PEX14 FURIN BGLAP SPP1 IL33 RNF20 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC HLA-A RORA DLST VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT H2AC19 H2BC26 H2AC14 H2BC21 EP300 SOCS3 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RARA ETFB RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FBXO32 H2BC1 H2AC20 KDM1B NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 RABGGTB RABGGTA GALNT12 DPAGT1 SEMA5A ST6GALNAC1 SPON2 SEMA5B CMAS ST6GALNAC2 SPON1 THSD7B MPI ADAMTS4 HK1 ADAMTSL1 GMPPB NANP ADAMTS5 C1GALT1C1 FPGT ADAMTS2 GMPPA PGM3 ADAMTS3 ADAMTSL5 GNPNAT1 ADAMTSL4 GFUS NANS ADAMTS1 NUDT14 ADAMTSL3 ALG8 ADAMTSL2 ST6GAL1 MUC12 THSD7A ST6GAL2 ALG9 MUC15 ALG6 ADAMTS8 ALG5 ADAMTS9 ADAMTS6 SLC35C1 ADAMTS7 ALG14 ALG2 SBSPON ALG3 MUCL1 MUC3A ALG13 MUC5AC ALG12 MUC3B ALG11 ADAMTS20 ALG1 B3GLCT ALG10 CFP RENBP TRIM28 DHDDS THBS2 ADAMTS12 DPM1 THSD1 DPM2 THSD4 DPM3 ADAMTS10 RFT1 ADAMTS16 MVD ADAMTS15 ST6GALNAC3 ADAMTS14 ALG10B ST6GALNAC4 MUC1 ST6GALNAC5 MUC2 ADAMTS19 ST6GALNAC6 ADAMTS18 GNE ADAMTS17 UAP1 NPL MUC7 FUOM MUC4 NEU2 MUC6 NEU3 MUC16 NEU4 GALNT3 MUC17 DHRSX C1GALT1 GMDS AMDHD2 MUC19 NEU1 SSPOP MUC5B ST3GAL4 ST8SIA4 MUC20 MUC21 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 DPH1 ST3GAL2 DPH2 FBXL21P ST3GAL3 DPH3 MPDU1 DPH5 CTSA DNAJC24 DPH6 NUS1 SLC35A1 DPH7 PMM1 EEF2 ST8SIA1 UBXN1 ST8SIA2 NGLY1 GFPT2 RNF139 PMM2 MLEC ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor BAX NTRK3 NELFB DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing NTHL1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 FUT2 FUT1 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 ABO FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 RHCE RHD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence LIG1 BRCA1 TERT MCM5 MCM2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR CRLF1 TYK2 IL6ST LIF IL11 OSM OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA CTF1 CLCF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways TAS2R10 SEL1L TAS2R13 TAS2R14 TAS2R16 AVPR1B TAS2R40 AVPR2 TAS2R41 TAS2R43 AVPR1A TAS2R46 DERL2 ERLEC1 OS9 TAS2R30 TAS2R31 TAS2R38 TAS2R39 SSTR3 TAS2R50 MCHR1 PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 DNAJB1 GNA13 FGD3 PTGES3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 FKBP4 NGFR ARHGEF35 ARHGEF37 SOCS1 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 CYP26A1 MYD88 CYP26B1 CYP26C1 WWOX TAS2R7 TAS2R8 UBE2D2 UBE2D3 RBX1 EPAS1 HIF1A GRM4 VHL TAS2R1 TAS2R3 TAS2R5 TAS2R4 FES PIP5K1C POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 ACTB TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 CSNK2A1 CSNK2A2 CSNK2B TP53 ARL2 GNG10 CHD8 CBY1 GNG12 SOX3 GNG11 SOX17 GNG13 SRY CCT6A GNB2 SOX6 GNAQ SOX7 GNB1 SOX4 BCL9L CTNNBIP1 GNB4 SOX13 GNB3 PYGO1 BCL9 GNB5 PYGO2 GNGT1 ICMT TUBA1B GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 NUP107 AAAS NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 HECW1 ERCC6L ZWILCH KLHL12 BUB1B WNT3 ACTG1 CCDC88C CDC20 DACT1 WNT8A PPP1CC WNT8B PPP2R1B PPP2R1A CXXC4 KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B CHUK MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 MTMR4 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE DGKG CENPF DGKE DAGLA FMNL1 DGKD FMNL2 CENPH DGKB CENPI DGKA TAOK1 ABHD6 CENPK ABHD12 CENPL PRKCH CENPM DGKZ CENPN DGKQ DAGLB B9D2 CENPO DGKK CENPP DGKI CENPQ DGKH SPC24 SPC25 MAD2L1 DUSP8 CENPS DUSP9 FLT1 FLT4 MRAS KDR VEGFB PORCN VEGFC VEGFD PGF NF1 VEGFA DUSP10 ESRP1 GNA12 SHOC2 SPRED3 SPRED2 SPRED1 CCNT1 CD274 IL2RG NELFB KANK1 STRN MAP2K5 NCBP1 NRP2 NCBP2 CDH5 CDK9 ADH1C CRABP2 ADH1A LFNG CRABP1 JAG1 SDR16C5 ADH4 RDH11 RDH10 RDH16 WNT9B RDH14 RDH13 DLL1 AKR1C3 DHRS3 WNT4 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 SKP1 ALDH8A1 FGFRL1 CUL1 FLRT2 FLRT1 EVC2 IQCE EFCAB7 EVC BOC GAS1 NTRK3 DRC4 PMEPA1 BAMBI NTF3 CDON STRAP WWC1 NEURL1B DLGAP5 HES5 PTCRA RASGRP2 MIB2 RASGRP1 PBX1 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 TACC3 RAF1 PRKACA PRKACB RAPGEF3 RAPGEF4 CYSLTR1 TRPC7 TRPC6 PLCG2 TRPC3 RCOR1 LAMA5 LAMA2 SH3KBP1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 CHRM2 JAK3 CHRM3 CHRM1 CHRM4 CHRM5 HNRNPA1 LIMK2 RPS6 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GPNMB LRRK2 PTK6 RACK1 HBEGF TRAF1 HSP90AB1 TWF1 OPRD1 MSI2 RHOBTB2 ACTN1 TMOD3 LYPLA1 DDX39B RBCK1 PHIP FSHB INHBB INHBA INHA PRKAA1 PRKAA2 PTPRK EPS15L1 CAB39 EPN1 CAB39L PRKAG1 SPRY1 PRKAG2 PTPN3 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR LRRC41 FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 KBTBD7 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 FST ARHGDIB RAC3 FOXH1 ACVR1B EMD LBR ACVR2B GIT1 ACVR2A DRAP1 TMPO SWAP70 ACVR1C ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 RNF41 GARRE1 AMIGO2 NOXO1 CUL5 ARHGAP17 WDR83 SLC1A5 SYNGAP1 ARHGAP15 PAQR3 ARHGAP21 RGL3 LMAN1 RGL2 PAK1 PEA15 PGRMC2 DUSP5 RACGAP1 DUSP2 SLITRK3 DUSP1 NHS ABL2 IL17RD RAPGEF2 SLITRK5 DAB2IP NCKAP1L SEPTIN7 WASF1 CDC14B PAK2 RAG2 YKT6 RAG1 WASF2 PAK4 RASAL1 IL32 RASAL3 GIT2 RASGRP4 CAV1 RASGEF1A ETV4 MCAM RASA3 ERBIN RASA4 ARHGAP26 RASA2 BAIAP2 MPP7 ABHD17C VANGL1 IGF2BP1 MAPK6 ARHGAP32 MAPK4 ABI2 TAOK3 ANGPT1 NOXA1 ABHD17B ABHD17A ABI1 TEK NOX3 ESYT1 FERMT2 NOX1 TGFB1 UBE2M TGFBR1 TGFBR2 LMNB1 CPNE8 OXER1 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG TAX1BP1 FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 STMN1 ARHGAP33 RBFOX2 ARHGAP31 PDGFD DNMBP SHB ARHGAP30 MAP3K11 FGFBP3 FGFBP1 CDC42SE2 FGFBP2 DOCK6 ARHGAP9 ARF6 ARHGAP11B ALKAL2 ALKAL1 DUSP16 DOCK9 TIA1 DOCK8 TNK2 DOCK7 WASL ADAP1 ARHGAP4 ESRP2 SH3PXD2A PTPRZ1 RAMP2 TAGAP CSN2 CALCA PLEKHG3 TIAL1 RAMP3 PLEKHG4 SH2D2A CALCB PLEKHG1 PAG1 CALCR RANBP10 CALCRL ARAP1 GMIP ADM2 PTPRO ARFGAP3 PTN ADM ARFGAP2 IAPP AXL PLAT RAMP1 ARHGAP10 FAM83D CDC42EP5 FAM83A CDC42EP4 MXD4 CDC42EP3 LTK CDC42EP2 THBS4 WAS THBS3 PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B ITGAV COL4A2 NCAM1 ITGA5 COL4A1 PTPRS SPARC ITGB5 SERPINE1 SPOP ITGB6 ITGA2 ITGA8 TGFB2 TGFB3 COL9A1 COL9A3 COL9A2 CHD3 BMI1 RING1 HDAC4 HDAC2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 AMER1 NPHP4 GSK3B CSNK1A1 AXIN1 APC OPN1SW CDC73 LEO1 HHAT SHH DHH ATF1 CREBBP IRAK4 SP1 MAPKAPK3 BCL2 AREG BCL2L1 MYOG PTPN6 MYOD1 TACR2 MYF6 TACR3 TCF4 TAC3 TACR1 MYF5 TAC1 CAMK4 HHIP NTF4 S100B NTRK2 DISP2 SAA1 BDNF ULK3 SCUBE2 TAB3 DZIP1 TGFA TAB2 FOS SPOPL FOXO3 ELK1 PTK2 EREG UHMK1 BTC MC2R EPGN AKT3 JUN FZD7 WNT5A ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SPPL2B SPPL2A CX3CR1 ATP2A3 CLIP3 NSMAF ATP2A2 ATP2A1 PRKG2 OPN3 RRH PTGIR RGR PLA2G4A OPN5 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 RXFP2 RXFP3 CRHBP PDE11A CMKLR1 PDYN AGTR2 FPR3 GALR3 GALR2 NOS3 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 PTH1R UCN3 UCN2 GPR37 PDE10A GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR CDC14A MTNR1A MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 APLN GPR37L1 TAS2R19 KEL TAS2R42 HGS TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R DUSP4 SSTR1 DUSP3 SSTR2 VRK3 WNT16 DUSP6 SSTR4 DUSP7 SSTR5 CORT MAPK7 NPY4R OPRL1 PTHLH CNR2 CNR1 PIP5K1A TSHR PIP5K1B ACKR1 GOLGA7 ZDHHC9 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR TRRAP CCP110 AGT AR CFTR GATA3 SNX3 RHOT1 CSNK1G2 RCE1 ZRANB1 STAM CYLD OTUD7B RAB4A IKBKG RIPK2 UCHL5 KAT2B PIK3CD KAT2A NEDD8 USP9X USP17L2 RNF146 YY1 RUVBL1 MAP3K7 USP8 CER1 USP7 USP4 USP2 STAM2 VCP TNKS ADRB2 FOXO4 RIPK1 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MDM2 TAB1 USP34 PTEN TNFAIP3 ARRB1 RGL1 ARRB2 TRAF2 AXIN2 TRAF6 BIRC2 BIRC3 USP13 USP15 TNKS2 USP21 OTUD3 CKB GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PPP1R1B PDE3A CCL4L2 HNRNPM RGS8 SNW1 PDE8B PDE8A PCP2 HNRNPF GRK3 GRK6 GPSM1 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 PDE7B PDE7A HNRNPH1 MEMO1 CTNND1 AMH NOG CTNNA1 PPP1CA SNAI1 PPP1CB TERT USF1 DDX5 CCR5 CXCR4 NPFFR2 OXTR NPFFR1 RGSL1 GRPR EDNRA EDNRB PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT YBX1 NTSR1 PTBP1 NTSR2 GPR17 NMB XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GCGR GPR4 GCG MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 KIT RGS17 HTR2B RGS19 HTR2C RGS13 ADRB1 RGS16 P2RY6 ADRA1D HTR2A P2RY2 P2RY1 ADRA1B HTR4 RGS21 CCK ADRA1A HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 COL6A2 ADRA2C HTR5A ADRA2B COL4A4 TAAR1 COL6A1 ADRA2A GPR143 COL4A3 ADRB3 ATF2 COL6A3 RBPJ COL4A5 COL6A6 COL6A5 MEF2C B4GALT1 SPINT1 HPN SPINT2 HGFAC POGLUT1 POFUT1 MYL9 VPS29 VPS35 WLS VPS26A TMED5 TLE5 SFN COL1A2 EZH2 HEY1 CASP10 HEY2 MYLK HELLS KLF16 PPARG PPARD SPP1 RICTOR MBD3 STAT1 GATAD2B GATAD2A SKI CCNT2 CDC25C PRDM4 BEX3 CFLAR MAPKAPK5 KMT2B FOXO6 FOXO1 SOCS3 ACVRL1 BMPR2 AMHR2 GDF2 TNFRSF10B SMAD9 TNFRSF10A SMAD5 GREM2 ZFYVE16 BMPR1B NFKB1 BMPR1A TNFRSF10D PIN1 FASLG E2F4 E2F5 SST IL2RA STUB1 TRIM33 CCNK CCNC THBS2 GALNT3 MUC20 SH3GL3 EPS15 SH3GL2 SH3GL1 WWTR1 YES1 SMARCA4 SYVN1 CLTB YAP1 WNT5B ROR1 ROR2 PRICKLE1 RELA WNT1 FZD1 RYK FZD8 RHOT2 RXRG ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 ITCH KLC1 GPAM KLC4 KLC3 KLC2 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH NF2 ACTR3 PRDM1 ACTR2 NR3C1 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B IRAK1 KIF5A NCKIPSD RAP1GDS1 KDM4C IL2 IL3 IL6 BMP2 TCF3 YWHAE PRR5 LEP DPY30 CHD4 YWHAQ YWHAG YWHAH TGIF1 TBP TGIF2 EED STK4 SAV1 STK3 MOB1B MTA2 LATS1 MOB1A LATS2 AMOTL2 PENK AMOTL1 REST CARM1 KRAS CHRDL1 MMP2 MAML2 MAML1 VGF PIP4K2A PIP4K2B PIP4K2C JUNB RNF111 MED1 PRKCB FSTL1 FSTL3 PRKCQ MAML3 NOTUM CRKL MAPKAP1 NEDD4L SORCS3 CGA C3AR1 C5AR2 C5AR1 C5 RET RARG CD19 ASH2L GLI3 GLI2 RSPO3 CD55 TCF12 RARB CDKN2B WWP1 PTPN18 PF4 PTPN12 CSF2 PTPN7 PTPN2 MEN1 MST1 PGR MST1R FKBP5 ABL1 FPR1 SKIL CDK8 TIMP2 CDK5 WDR5 CRH HDAC5 HDAC8 HDAC9 HDAC6 HDAC7 GPR84 RAB6A RBBP4 RBBP5 RAB4B RBBP7 PML HDAC10 HDAC11 SOX2 SOX9 RUNX3 CITED1 PARP1 PRMT1 SGK1 PTPRJ NPY TJP1 FAS CDK5R1 ATP1B4 KCTD6 CXCR1 CBX6 CXCR2 SMURF1 SMAD6 ESR2 NR4A1 NR2E1 CASP2 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 POMC CXCL1 BAX PHB1 ARAF PEBP1 ADGRE5 CSK JAK2 ADGRE3 MARK3 FGB BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 TNS4 TNS3 SYK LCK FYN F2 DBT DLD CLTC CXCL6 CXCL9 CLTA CXCL8 CXCL13 AP2A1 CXCL3 CXCL2 AP2A2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 AP2M1 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 AP2S1 CCL22 CCL21 CCL20 CXCL10 CXCL11 CXCL12 ACKR4 ACKR3 ACKR2 AP2B1 CCL28 CCL27 P4HB POU2F1 STAT5A PXN FLNA GLI1 GRAP2 SUFU BTRC NUMB MTA1 MTA3 PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 GNAO1 NAB1 NAB2 LYL1 F3 DNM2 ARC TRIB1 TPH1 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 ID1 ID4 FOSB ID3 CDK5R2 TGFBR3 LRIG1 SOCS6 SH2B3 IKBKE BAG4 MATK GIPC1 ANOS1 WNT3A OFD1 LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 CSNK1E SFRP2 WIF1 SOST IRS4 IGF1R CILP KDM4B DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 OPN1LW CGN F11R PRKCZ PARD3 SMC1A SMC3 STAG1 STAG2 RAD21 NRG3 NRG4 NRG2 H3-4 ARL13B PDE6D FABP5 FABP7 PLIN3 MGLL GGA3 PDK4 RASGRP3 PIK3AP1 IL5RA CSF2RB CSF2RA STAT5B NCOA2 IL5 IL3RA IL2RB NCOA3 GRB2 NR5A2 CTBP2 CTBP1 DNMT1 PPP5C TNF WNT10B STAT6 PDGFRB FOXA1 ZDHHC7 TLE3 PPID CAV2 GREB1 CHD1 MMP7 TFF3 TFF1 ZDHHC21 CXXC5 USF2 ZNF217 EBAG9 SMPD3 SMPD2 PSAP GSK3A NTRK1 KIDINS220 CRK UBE2L3 TNFSF10 FADD PPP3CC C1QBP SPTAN1 BCAP31 TJP2 FNTA OTULIN TRADD CASP8 FLOT1 FLOT2 DSP DSG1 UACA GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 TMED2 FCER2 RFNG MFNG MDK ACTA2 LINGO1 MAG OMG RTN4 GPC5 ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 UCN CRHR2 TSHB LYN PIK3CG PIK3R6 PIK3R5 BTK RALA CFL1 JAK1 TYK2 AAMP MKNK1 SPRY2 ALK AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 GIP FFAR1 GNAZ ADORA2B JAG2 ADAM17 RDH5 CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 SNAI2 OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 PTPRU WWP2 WDR11 SH2B2 LETM1 CMA1 TMEM59 FER TEC VMA22 GRAP GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 RNF43 ZNRF3 FAM91A1 RSPO2 TEX2 RSPO1 ARMCX3 LGR6 PKP4 LGR5 RASAL2 KLB RSPO4 STIP1 LGR4 DDRGK1 FLT3 PLXNA1 IRS1 ANKRD26 PDE3B IRS2 NSFL1C CPD PIK3CB PLXNB1 TCIRG1 ARHGAP11A IDE FGF1 ZNF512B FGF2 CAPZB FGF3 EFHD2 NCK2 PTPRF FGF4 WDR6 FGF6 NCK1 FGF7 DST FGF9 PLEKHG6 AKT2 NIPSNAP2 BLTP3B GRB10 ATP6V1E1 PARD6B SH3BP1 CTSD WHAMM ATP6V1E2 HRAS WASF3 ATP6V1G1 NDUFA5 PCDH7 ATP6V0B ATP6V0E1 SEMA4F ATP6V1G2 PTPN13 ATP6AP1 VAPB PDPK1 GOLGA3 GAB1 BAIAP2L2 KCTD13 FLT3LG FRS2 TMEM87A GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 SCFD1 SPTBN1 TLR9 EPO EPOR PIK3C3 CCDC88A TRIB3 FRAT1 ANLN FRAT2 ATP6V0D1 FAF2 KIF14 SOS1 SH3RF1 ATP6V0C AKAP12 ATP6V0D2 ATP6V1B1 GFAP HINT2 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 RHOH PIK3R1 RHOF INS RHOJ NRAS RHOU ATP6V0A2 RHOV FGF20 RHOQ THEM4 SAMM50 EMC3 ATP6V1H MTX1 MAPK1 ATP6V0A4 CAVIN1 MYO9A ATP6V0E2 ATP6V1G3 TRIP10 FGF23 RTKN PRAG1 ATP6V1D FGF22 SYDE2 ATP6V1C1 BASP1 ALDH3A2 ATP6V1F ATP6V1C2 ELMO2 DDX4 ATP6V0A1 MAPK3 ARHGEF28 PTPN1 ARHGAP19 INSR ARHGAP18 TOR1AIP1 PTPN11 FGF16 ARHGAP12 PLD2 FGF19 RHPN1 FGF18 RHPN2 FGFR4 FGF10 FAM83B ACBD5 MACO1 SHARPIN ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 CAMK2B DLG5 PICALM CAMK2D SRC DOCK5 ACTN2 DOCK4 ABCD3 CAMK2A NRG1 DOCK3 SOWAHC GRIN2B MTR TNFAIP1 RND2 GRIN2D GRIN1 RND3 RND1 DLG1 CKAP4 DLG2 SENP1 ZAP70 DLG3 GFOD1 LRRC7 ALS2 DLG4 NEFL PEAK1 CALM1 NDUFS3 DOCK2 CAMK2G DOCK1 CCDC187 IER3 MECOM MOSPD2 FAM169A PHLPP2 ADD3 PLK1 PHLPP1 PTK2B CD86 UBE2D1 CD80 HSPE1 ATN1 SLC4A7 ACTC1 SALL4 MAF1 PDHB TRAT1 RPS6KB2 CDK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 GLP1R VIPR1 VIPR2 RANBP9 SCT KAT5 GIPR GHRHR CHEK1 GLP2R SCTR GHRH VIP OPTN PPP1R12A SEM1 APP HGF CLIP1 PDGFB KNG1 IGF2 IGF1 CCR6 PPBP CCR2 TIMP1 S100A9 S100A8 PLG PLPPR1 PLPPR2 PLPPR3 ELANE PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PDGFRA GTF2A1 GTF2A2 BMP10 LTBP4 P2RY12 P2RY13 P2RY14 P2RY4 LTBP3 ADORA3 ADORA1 LTBP1 SCD FASN ITGB8 ULK1 TCF7L2 CDKN1A TCF7L1 HDAC1 LEF1 TCF7 FLRT3 CCND1 SIN3A CDK2 CTNNB1 MET PPP1R15A PTPRA SPTB TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB HSPB1 PSMD8 PSMD6 PSMD7 SPTBN4 XPO1 SPTBN5 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 ARTN PRKCD PRKCA GFRA1 YWHAZ GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 PSMA4 GFRA4 PSMA1 PSMA2 MAPKAPK2 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 CASP9 MMP14 MMP16 CASP3 XIAP C3 DHRS4 FURIN PCSK6 NGF PCSK5 IL1RL1 IL33 RNF20 SPEN IFT172 CCT2 IFT52 CPSF7 ROCK1 IFT57 ROCK2 DYNC2H1 IFT140 GPS1 ADAM12 RPGRIP1L CUL3 TXNL1 KIF7 WDR35 RHOBTB1 SRRM1 IFT88 SMO COPS4 TRA2B GPR161 COPS2 INTU TULP3 MYO6 STK38 KIF3A TTC21B PDE5A RBBP6 PTCH1 WDR19 VIM HNRNPC IFT122 FUZ CCT7 ADCY10 RBMX MKS1 DBN1 DTX4 TBK1 ELMO1 CD28 OPN1MW RASGRF1 RNF31 SPATA2 TNFRSF1A LIN7B OTUD1 TRIM27 HSP90AA1 NEDD4 MKRN1 EGF FRK CBL EGFR CDC37 PLCG1 CDKN1B CCND3 FNTB E2F1 RHO E2F3 GNAT1 TFDP1 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L PELP1 H2BC21 DOK1 MYB EP300 SFPQ IL6R RASA1 KHDRBS1 H3-3B KHDRBS2 H3C8 KHDRBS3 H2AC8 H2AC6 STAP2 H2AC7 SRMS BCAR1 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RARA CBFB H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CETP KDM3A HDAC3 KDM1A KDM1B GNAT3 GPS2 RXRB NRIP1 APOD GABRG3 UGT1A3 APOE GABRG2 TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 GABRB3 NR1H3 GABRB2 NCOR2 ARL4C GABRB1 EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ABCG1 GNAI3 GNAI1 GNAI2 GABRQ GABBR2 GABRA1 GABBR1 ST3GAL4 ST3GAL6 AVP ST3GAL3 MEF2D TAS2R20 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 NKX2-5 KAT2B WWTR1 TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 CCN2 HIPK2 TBX5 GATA4 NPPA ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 ITGB4 COL15A1 ITGA6 PLEC COL11A1 COL11A2 LOX COL10A1 COL27A1 COL24A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL6A3 BMP1 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CTSS TLL2 TLL1 LAMB3 LAMA3 LAMC2 COL1A1 COL1A2 MMP9 PXDN MMP3 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME ABCC5 GSTA2 NUDT15 IMPDH1 HPRT1 IMPDH2 GMPS GSTA1 SLC28A2 RAC1 SLC29A1 TPMT VAV3 NME1 ABCC4 SLC29A2 SLC28A3 GSTM1 NME2 XDH VAV1 VAV2 GUK1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination YAP1 CYP51A1 POU3F1 MPZ SREBF2 ADGRG6 LAMA2 DRP2 HMGCR PRX LAMB1 LAMC1 PMP22 SOX10 NAB1 NAB2 UTRN EGR2 DAG1 POU3F2 MAG HDAC2 TEAD1 WWTR1 SMARCA4 SCD5 MBP ADGRV1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 TRIM27 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PML UBE2I PIAS1 SUMO1 MDM2 NUP205 POM121 NUP107 NUP188 AAAS VHL NUP160 NUP214 POM121C NUP42 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ1 KCNJ16 KCNJ10 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 CNGA2 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 GNG13 GNB1 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC9 METTL23 H4C9 H2BC8 H2BC26 H2BC5 H2BC3 H2BC12L H2BC21 NPM2 H2BC1 H3-3B SRPK1 H1-8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HIRA H2AX PRM2 PRM1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 HNRNPA2B1 SOD2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 MIF SOD1 MTAP GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 PPIA SNRPA1 PAK2 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 CHMP3 CFTR CHMP6 CHMP7 UBA52 ARL13B HBB HDAC6 PLIN2 IFT88 UBB UBC RPS27A PLIN3 CHMP4C CHMP4B VPS28 TSG101 HSPA8 CHMP4A VPS37C VPS37D VPS37A VPS37B CHMP2B MVB12B PCNT CHMP2A MVB12A UBAP1 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer NTRK3 NTF3 PDGFB RICTOR FOXO4 ESR1 MDM2 CD28 PRR5 PTEN GSK3A EGF EGFR CDKN1B KLB FLT3 IRS1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 PDGFRA RAC1 PDPK1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 MAPKAP1 HBEGF RAC2 RHOG PIK3R2 PIK3R1 CDKN1A FGF20 FGF23 FGF22 CHUK MET BAD PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 MLST8 TSC2 ESR2 SRC NR4A1 MTOR NRG1 AKT1S1 AKT1 PIK3AP1 GSK3B CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 RPS6KB2 PIK3R5 STRN PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA FOXO3 HGF EREG CASP9 BTC EPGN AKT3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism CYP27B1 GC PIAS4 CYP24A1 CYP2R1 LRP2 SUMO2 LGMN UBE2I VDR LDLRAP1 CUBN MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis PPIA HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 PARP1 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 FEN1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A POLQ GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALK1 PGM1 GALE GALM GALT AKR1B1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CCNB1 CDK1 ORC5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF COL4A2 COL4A1 SOS1 FURIN STAT3 PIK3R2 PIK3R1 PDGFB NRAS SPP1 COL6A2 COL4A4 COL6A1 COL4A3 STAT1 PTPN11 COL6A3 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 SRC PLG CRK STAT5A STAT5B THBS1 PLCG1 THBS2 PDGFD PTPN12 PIK3CB RAPGEF1 PLAT NCK2 NCK1 THBS4 RASA1 THBS3 PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis PEX3 ABCA10 ABCG4 ABCA3 ABCD2 ABCA6 ABCA2 ABCA5 ABCG1 ABCA9 ABCD3 ABCA7 APOA1 ABCD1 ABCA12 ABCG8 PEX19 ABCG5 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5PO SAMM50 MTX1 APOOL CHCHD3 DMAC2L HSPA9 ATP5MC2 ATP5MC3 ATP5MK ATP5MJ MICOS13 MT-ATP6 MICOS10 ATP5MC1 CHCHD6 ATP5MG ATP5MF ATP5ME APOO DNAJC11 IMMT TMEM11 ATP5F1A ATP5F1B ATP5PF MTX2 ATP5PD WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 CLTC CLTB PRKCA FZD4 WNT5A AP2S1 CLTA AP2A1 AP2A2 AP2B1 AP2M1 PRKCB DVL2 PRKCG ARRB2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation KDELR1 SEL1L RNF185 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 MGAT3 KDELR2 SAR1B COPB2 COPA TMED10 B4GALT6 DERL1 B4GALT5 DERL2 MAN2A2 SERPINA1 RNF5 OS9 COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 TMED7 TMED9 COPZ2 BET1L COPZ1 USO1 ARF5 NAPA GBF1 NAPB SPTAN1 RAB1A RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 GORASP1 B4GALNT2 ARCN1 COPG2 COPG1 B4GALT2 B4GALT3 B4GALT4 CGA RPN2 TUSC3 PRKCSH DCTN6 RPN1 DCTN5 DCTN1 MAGT1 DCTN4 FUT8 GANAB MAN2A1 MGAT5 CAPZA3 MGAT1 MGAT2 CAPZA2 COL7A1 OST4 EDEM2 ACTR10 MOGS ARF3 SEC31A DDOST MGAT4C TMEM258 DAD1 OSTC TMED2 MGAT4A CALR CANX SPTB MGAT4B STT3A STT3B B4GALT1 MAN1B1 ANK2 ANK3 CD59 CD55 SPTBN4 SPTBN5 SPTBN2 ASGR1 ASGR2 UBA52 ACTR1A ARF1 SPTA1 PDIA3 CSNK1D UBB UBC RPS27A CAPZA1 DCTN2 DCTN3 UMOD LMAN1 GOSR2 PSMC1 YKT6 ARFGAP1 PREB SRD5A3 KDELR3 VCP FUCA1 TRAPPC4 SEC22B LHB SEC23A SEC24B GLB1 SEC24A STX5 RAD23B ANKRD28 SEC13 PPP6C PPP6R3 SEC24D SEC24C TRAPPC1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 CTSZ DYNLL2 NSF CTSC DYNC1I2 DYNC1I1 DYNC1H1 GRIA1 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT TFG GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 COPB1 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS GOLGB1 DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 ANK1 SLC17A5 ST8SIA5 AREG ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 UBXN1 ST8SIA2 NGLY1 RNF139 GFPT2 MLEC PMM2 TGFA ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria BAX CYCS BAK1 GSDMD DIABLO GSDME DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBIN HSP90AA1 ERBB2 CDC37 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGA5 FN1 ITGB1 CEACAM1 CEACAM6 CEACAM8 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation SGSH AGRN NAGLU GPC1 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 HSPG2 SDC1 CTSL HPSE SDC4 HPSE2 SDC2 SDC3 IDS UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria E2F1 BBC3 TP63 TP73 PPP1R13B TP53 TFDP1 TFDP2 TP53BP2 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GUSB ARSB GYG1 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 ALDOB EPM2A DCXR GNS SI PPP1R3C LCT HGSNAT NHLRC1 GAA G6PC3 UBB SGSH UBC TALDO1 KHK RPS27A GALNS NAGLU SLC37A4 RPIA IDUA HYAL1 GLB1 IDS SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF10 LAMA5 FGF2 LAMA2 LAMB3 LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection AP2A1 AP2A2 NPM1 AP2M1 CCR5 CXCR4 AP2S1 AP2B1 TAF4B TBP TAF9 TAF1L NMT1 BTRC TAF15 TAF12 TAF13 TAF11 TAF8 KPNB1 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C CHMP4B CHMP4A RAC1 GTF2A1 CHMP2B GTF2A2 GTF2B CHMP2A GTF2E1 GTF2E2 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 TAF7L FEN1 PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 RNMT CCNH PSMA5 PSMA6 POLR2A PSMA3 POLR2B PSMA4 POLR2C PSMA1 POLR2D POLR2E RAN PSMA2 POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J ARF1 PSMD12 POLR2K PSMD11 POLR2L RNGTT GTF2H1 PSMD14 GTF2H2 GTF2H3 PSMD13 SUPT5H PSMA7 GTF2F1 GTF2H4 PSMB6 GTF2F2 GTF2H5 PSMB7 CDK7 ERCC3 PSMB4 ERCC2 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PPIA PSMC5 PSMC6 PSMC3 TAF9B PSMC4 PSMC1 PSMC2 PAK2 FURIN AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NMT2 LIG1 RCC1 TAF10 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 XRCC6 XRCC4 XRCC5 LIG4 RANGAP1 ATP6V1H DOCK2 CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 HCK SEM1 LCK FYN SKP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 EPB41L1 KCNMA1 KCNMB1 CASK KCNQ4 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A MYH9 TMC2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 USH1C SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters SLC17A1 SLC20A2 SLC34A3 SLC34A2 SLC20A1 SLC34A1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events H2BC9 CHMP3 H4C9 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 H2BC1 H2AC20 H2AC1 HNRNPK H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 H2BC18 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 NUP37 VPS36 VPS25 SNF8 CHMP1A H2AC19 H2BC26 H2AC14 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 CEBPD H2BC17 VPS4A CHMP2B H2BC12 MVB12B CHMP2A H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 H3C15 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport KDELR1 KDELR3 DYNLL1 FOLR1 INS BET1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 COG8 COG7 COG6 NSF COG5 COG4 COG3 CAPZA3 COG2 COG1 CAPZA2 DYNC1I2 ACTR10 ARF3 KDELR2 COPB2 COPA TMED10 TMED2 SPTB DYNC1I1 DYNC1H1 COPE ARF4 ANK2 ANK3 CD59 CD55 SPTBN4 TMED3 SPTBN5 SPTBN2 TMED7 TMED9 COPZ2 COPB1 BET1L STX5 COPZ1 USO1 ACTR1A ARF1 ARF5 GOLGB1 NAPA GBF1 NAPB SPTAN1 SPTA1 RAB1A RAB1B GOSR1 GOLGA2 NAPG ARFGAP3 ARFGAP2 CAPZB DYNC1LI1 GORASP1 ANK1 DYNC1LI2 ARCN1 DCTN2 CAPZA1 DCTN3 COPG2 GOSR2 COPG1 YKT6 TMEM115 ARFGAP1 SPTBN1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis B3GNT5 B4GALT6 B4GALT5 FUT2 FUT1 ST8SIA5 UGCG ST3GAL5 UGT8 ST3GAL2 ST3GAL3 B4GALNT1 GAL3ST1 CERK B3GALNT1 B3GALT4 ST6GALNAC5 ST6GALNAC6 A4GALT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RAPL1 IL1RL2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism GCDH HYKK AADAT PIPOX SLC25A21 CRYM AASS DHTKD1 ALDH7A1 DLST PHYKPL DLD TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR2 ARRB1 ARRB2 TGFBR3 TGFB2 TGFB1 GIPC1 TGFBR1 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease SOS1 CEP43 STAT3 PIK3R1 ERLIN2 NRAS FGF20 FGF23 FGF22 STAT1 FGF16 FGF18 FGFR4 FGF10 ZMYM2 FGFR1OP2 POLR2A BAG4 POLR2B STAT5A STAT5B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRIM24 PLCG1 POLR2I FGFR3 POLR2J POLR2K POLR2L GTF2F1 CPSF6 GTF2F2 FGFR1 MYO18A LRRFIP1 CUX1 BCR NCBP1 NCBP2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 GAB2 PIK3CA SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs RPS6KA1 CLTC CLTA AP2A1 AP2A2 FURIN NTRK3 PCSK6 NTF3 NGF PCSK5 AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB PTPRO VGF EP300 JUNB RAC1 HRAS GAB1 FRS2 MAP2K1 CRKL MAP2K2 PIK3CA TIAM1 SOS1 DUSP4 DUSP3 VRK3 PTPRS DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 PTPN11 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 SRC ADCYAP1 ADCYAP1R1 YWHAB SHC2 DOCK3 SHC3 RALGDS GRIN2B DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA BAX ATF1 NELFB BRAF MAP2K5 RAPGEF1 MAPKAPK3 FRS3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTF4 NTRK2 BDNF FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f MPDU1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS ABCC2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling PRKCA SOS1 SH2B2 LYN CBL PTPN6 YES1 LCK FYN KIT SOCS6 SH2B3 SOCS1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) PTPRO SOS1 PTPRS NTRK3 NTF3 PIK3R1 NRAS PLCG1 SRC BAX HRAS PIK3CA NELFB IRS1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A7 SLC4A4 AHCYL2 SLC4A8 SLC4A9 SLC4A10 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion INMT RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins OCLN APC DSG1 DSG3 PLEC ADD1 BIRC2 ROCK1 SPTAN1 LMNB1 CTNNB1 DBNL TJP1 ACIN1 GAS2 MAPT BCAP31 VIM GSN CLSPN TJP2 FNTA DSG2 PKP1 CDH1 BMX SATB1 STK24 STK26 PRKCQ CASP8 CASP6 PTK2 CASP7 DSP CASP3 PRKCD TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands IGFBP3 TNFRSF10C TP63 TP73 PPP1R13B TNFRSF10B TNFRSF10A FAS TP53 TMEM219 TNFRSF10D TP53BP2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR DLAT PDHX PDHA2 PDHA1 PDHB DLD GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR LYN STAT3 SOCS3 ADAM17 PTPN6 MAPK1 JAK2 SOCS2 CISH STAT1 MAPK3 PTPN1 SOCS1 IRS1 IRS2 GH1 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) SEL1L ERLIN1 ERLIN2 RNF185 VCP PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA1D GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY6 CACNA1C ADCY5 GNGT2 ADRA2C ADRA2A CACNB3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 GNAI1 CACNB2 GNAI2 GNG10 GNG12 GNG11 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA PRKCA ANP32A ELAVL1 XPO1 TNFSF13 NUP214 SET PRKCD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0D1 ATP6V1G1 ATP6V0B ATP6V0C ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V1H LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 CDH1 SH3GL1 CTNND1 UBA52 SRC STAM STAM2 CBLL1 CTNNB1 MET HGS UBB SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 ADCY9 TAS2R16 FZD8 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 PDE11A CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 PDE10A GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH TRIO MAS1 RASGRF2 XK ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 WNT6 VAV3 HCAR1 WNT2 ARHGEF11 PTCH2 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ WNT2B ARHGEF15 PLEKHG5 HEBP1 ADGRE1 ARHGEF17 GRM3 ARHGEF16 ADGRE2 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 WNT16 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN ACKR1 FGD1 FGD2 GNA13 FGD3 ABR FGD4 C5AR2 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 WNT3 WNT8A WNT8B PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 CCL11 CCL3L3 PRKACG CXCR5 CCR5 CXCR6 PRKACA CCL7 CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 RGSL1 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HBEGF HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA WNT3A WNT9A PAK1 C3 ROCK1 ROCK2 SMO PTCH1 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants CEP43 STAT5A STAT5B STAT3 PIK3R1 TRIM24 ZMYM2 CPSF6 FGFR1OP2 GAB2 MYO18A STAT1 PIK3CA LRRFIP1 CUX1 BCR FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 TEC IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 VAV3 PPP3CA PPP3CB PPP3R1 VAV1 VAV2 SOS1 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN BTK NFATC3 TXK SYK AHCYL1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation GCSH DLAT LIPT2 LIPT1 NDUFAB1 DLST FDX1 NFU1 DBT LIAS TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 PCNA UBC RFC3 RFC4 POLK RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly CHMP3 CHMP6 CHMP7 RANGAP1 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 PPP2CA TUBA3E TUBA3D TUBA3C UBE2I SUMO1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 TNPO1 NUP160 NUP85 NUP62 BANF1 SIRT2 NUP43 RAN NDC1 CCNB1 TUBB8 SEC13 NUP155 NUP133 IST1 VRK1 CDK1 LEMD2 NUP93 TUBB8B NUP35 EMD NUP54 LBR NUP37 KPNB1 SPAST CC2D1B LEMD3 PPP2R1A TUBB6 TUBB3 TUBB1 PPP2R2A CHMP4C RCC1 CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A CCNB2 AHCTF1 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 RXRB PLIN1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import PEX10 PEX12 PEX13 PEX14 SLC27A2 DHRS4 NUDT7 CRAT PECR ZFAND6 PEX26 SCP2 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 ECH1 PIPOX GNPAT ACOT2 ACOT4 UBE2D2 UBE2D3 NOS2 HACL1 HAO1 DECR2 HAO2 EPHX2 IDH1 TYSND1 UBE2D1 AMACR DAO CAT CROT UBA52 PEX2 PEX1 BAAT PEX7 UBB ACOX2 ACOX1 IDE UBC EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 AGXT PAOX HSD17B4 DDO HMGCL USP9X TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 PLK3 CNOT1 CNOT2 CNOT3 NPM1 CDC25C RGCC PLAGL1 TNKS1BP1 CNOT10 PLK2 CNOT8 CNOT9 CNOT6L CNOT11 TP53 BTG2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site CANX CALR INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling LCK JAK3 STAT5A STAT5B PTK2B SHC1 IL2RB JAK1 IL2RG IL2RA IL2 SYK BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA PHF1 H2BC9 H2AZ2 H4C9 JARID2 H2BC8 H2BC5 EED H2BC3 H2BC1 EPOP H2AC20 AEBP2 MTF2 RBBP4 EZH2 RBBP7 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EZHIP PHF19 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 EZH1 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 AR CFTR BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 NCOA2 PTK2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NCF1 ATP6V0D1 NCF2 ATP6V0C NCF4 ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H HVCN1 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F NOS1 ATP6V1C2 CYBB ATP6V0A1 CYBA LPO TCIRG1 SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B MPO ATP6V0E1 NOS2 ATP6V1G2 NOS3 ATP6V1B2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins NUP85 TPR PCNA NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 INCENP NUP50 BIRC5 NUP35 NUP54 NUP37 TOP2A AURKB PIAS3 SUMO3 SUMO2 UBE2I CDCA8 SUMO1 TOP2B TOP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle TRAK1 TRAK2 RHOT1 RAP1GDS1 MYO19 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS FMOD HEXB HEXA GNS GLB1L3 PRELP GLB1L2 OMD KERA GLB1L GLB1 ACAN OGN LUM RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 BRK1 ABI2 ABI1 ARPC1B ARPC1A ABL1 BTK MAPK1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ACTG1 MAPK3 ACTB CDC42 NCK1 WAS NCKIPSD WIPF1 WIPF2 CYFIP2 WIPF3 RAC1 WASF3 NCKAP1L WASF1 WASF2 PTK2 CYFIP1 NCKAP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PIP5K1C ARHGAP32 FURIN RPN2 PCSK6 JUP PRKCSH RPN1 GANAB CSNK2A3 PCSK7 CTNNB1 POMT2 SPCS3 SPCS2 SPCS1 OST4 SEC11A POMT1 SEC11C MOGS DDOST TMEM258 DAD1 OSTC CANX STT3A CDH1 CSNK2A1 CSNK2A2 ANK3 CSNK2B TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP BLM CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 CHTF18 RFC2 RFC1 STN1 RPA1 TEN1 RPA2 RPA3 DNA2 CTC1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 HRAS SOS1 NTF4 NTRK2 BDNF FRS3 FRS2 NRAS PTPN11 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism SLC2A1 CYB5R3 SLC2A3 CYB5A SLC23A2 SLC23A1 GSTO2 GSTO1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 PSIP1 PPIA HMGA1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release CANX CALR DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 GALK1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 IGHV3-23 V1-13 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-8 V1-20 IGHV3-33 IGKV1D-39 IGKV1D-33 V1-9 V5-4 IGKV2D-28 V1-7 IGKV4-1 V5-1 IGHV7-81 V1-5 V1-3 IGKV2D-30 V5-6 IGHV4-59 IGHV1-69 C1QB C1QA C1S IGLV2-11 C1R IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 V4-6 V4-2 IGKV3-15 V4-1 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 C1QC IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CRP IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair MBD4 H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 SMUG1 NEIL3 H2BC3 H3-4 PARP1 NEIL2 H2BC1 POT1 TERF2IP NEIL1 H2AC20 MPG FEN1 POLB H2AX PNKP LIG1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLE POLD2 OGG1 H2BC21 RFC2 RFC1 PARP2 LIG3 RPA1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 XRCC1 H2BC14 POLE4 H2AJ RPA3 H2BC15 H2BC11 POLE2 POLE3 PARG NTHL1 APEX1 ADPRS TDG MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 ABL1 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 MYBL2 DHFR TK1 CDKN2D CDKN2C CDKN1C RB1 DYRK1A CDKN1B CCND3 RRM2 CCND2 E2F1 RBBP4 E2F2 E2F3 SKP2 CABLES1 FBXO5 CDK6 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 TOP2A PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDKN2A CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN CCNB1 PSMA2 UBA52 CDKN2B PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 JAK2 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PPP2R2A PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBIN HSP90AA1 ERBB2 CDC37 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR FLRT1 SOS1 PIK3R1 NRAS FGF20 MAPK1 FLRT3 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 PTBP1 HNRNPM TGFBR3 HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L GIPC1 ANOS1 FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 SPRED2 SPRED1 ESRP2 KLB TIAL1 BRAF UBB GALNT3 PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 FMOD PRELP CHST6 OMD KERA ACAN OGN LUM ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions GJA10 PANX1 PANX2 GJD2 GJC1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation ARHGDIA NGFR NGF RHOA REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression CREBBP MAFK RELA NFE2L2 EP300 NFKB1 MYC NOTCH1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation ALDH1B1 ADH7 ACSS1 ADH5 ADH6 ADH1C ALDH1A1 ALDH2 ADH1A ADH4 ACSS2 ADH1B EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA1A XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGEF1 ARHGAP32 RHOC ARHGEF5 PIK3R1 RHOA ROCK1 CAVIN1 ROCK2 ABR RTKN ARHGEF28 ARHGAP18 MCF2 ACBD5 MACO1 FMNL3 ABCD3 FMNL2 ARHGDIA CIT ARHGEF25 CCDC187 PKN3 IQGAP1 TFRC IQGAP3 STX5 ARHGAP1 ARHGAP39 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK C1QBP LBR TMPO BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 LMAN1 STOM MCF2L ARHGEF40 RACGAP1 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 VAPB DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants HRAS NRAS KRAS SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border MSX1 DLX5 TFAP2A FGF4 TFAP2B BMP4 MYB TCF7L1 TFAP2C PAX7 POU5F1 SOX2 PAX3 ZIC1 WNT3A CTNNB1 GBX2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 TF CALU SERPINA1 MBTPS1 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 LAMB2 PDIA6 MXRA8 SPARCL1 FN1 LAMB1 SCG2 LAMC1 TGOLN2 STC2 PENK IGFBP7 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC GAS6 APLP2 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC22A5 PPARD CYP4B1 FAAH NUDT7 ACSM3 PCCA CRAT ECI1 PCCB THRSP ACSM6 PTGDS ACAD11 ACAD10 PLA2G4A GGT5 PTGES GGT1 DECR1 ALOX15B LTC4S GPX2 ACADL HADHB HADHA ACADVL ACADM ACADS CBR1 CYP2C9 NDUFAB1 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 SLC27A1 HACD1 TECR HSD17B3 PTGES2 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ACOT9 ELOVL1 OLAH CYP8B1 ELOVL4 ACOT7 ACSL1 MECR ELOVL5 ELOVL2 ACAA2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 HADH ACSL3 ACOT1 TECRL ACSF3 ACLY RXRA SCD FASN ACOT11 PPT1 ACOT12 ACSBG1 ACOT13 PPT2 SLC27A3 ACSBG2 SLC27A2 DPEP2 DPEP1 ALOX15 PECR THEM4 LTA4H PTGES3 CYP4F3 CYP4F8 SCP2 MCAT CYP2J2 NUDT19 ACBD7 PRXL2B ACBD6 ACOT7L ACAA1 ACBD4 PRKAA2 PHYH ACOT8 ACSF2 PRKAG2 MCEE ACBD5 PTGR1 ACOT2 CYP4A22 PTGR2 DBI ACOT4 PCTP ACOXL PRKAB2 ECHS1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 HACL1 PON3 HPGD DECR2 PON2 HAO2 PON1 EPHX2 FADS2 HPGDS FADS1 AMACR ALOX5AP MAPKAPK2 CROT CYP4F22 CPT2 MID1IP1 THEM5 SLC25A20 CPT1B ABCD1 CPT1A CYP4F11 SLC25A17 ACOX2 TBXAS1 EHHADH ACOX3 GPX1 GPX4 FAAH2 AKR1C3 HSD17B4 MMAA MMUT AWAT1 ALOXE3 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP3A7 CYP2E1 CYP2F1 ARNT AHRR CYP2W1 CYP2D6 ARNT2 CYP3A5 CYP2C18 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2J2 CYP2S1 CYP3A4 CYP1A2 CYP3A43 CYP2A7 CYP1A1 CYP2A6 AHR CYP2C19 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry AGRN ACE2 FURIN GPC1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 HSPG2 VCP TMPRSS2 NRP1 SDC1 CTSL SDC4 SDC2 SDC3 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus SQSTM1 UBC RPS27A NGF TRAF6 UBA52 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 MAPK8 ITGB3BP NGFR UBB FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 FGF23 FGF22 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B REST SRF NR3C1 KCNIP3 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members PMEPA1 FURIN BAMBI CER1 STRAP TGFB1 UBE2M TGFBR1 TGFBR2 SKIL SKI CDK8 SMAD2 TIMP2 SMAD1 SMAD4 SMAD3 YBX1 SMURF2 SMAD7 BMP2 TIMP1 CCNT2 TCF3 ARRB1 ARRB2 TGIF1 TGIF2 CBL USP15 TFDP1 TFDP2 PPP1CC CHRDL1 FGF2 EP300 JUNB PARD6A CGN F11R RNF111 PRKCZ PARD3 FSTL1 FSTL3 BMP10 LTBP4 RARA ITGB3 ARHGEF18 LTBP3 ITGB1 LTBP1 ITGAV NEDD4L RXRA ACVRL1 BMPR2 AMHR2 GDF2 SMAD9 ITGB8 SMAD5 ITGB5 SERPINE1 GREM2 ZFYVE16 PARP1 BMPR1B BMPR1A HDAC1 APH1A RHOA ITGB6 PSENEN MAPK1 NCSTN APH1B PSEN2 PSEN1 ITGA8 INHBB INHBA PPP1R15A INHA MAPK3 TGFB2 ATP1B4 TGFB3 NCOR2 TNRC6C MTMR4 MOV10 MYCN NCOR1 AGO3 AGO4 SNW1 MYC SMURF1 SMAD6 AGO1 TGFBR3 AGO2 TNRC6A TNRC6B E2F4 FKBP1A PPM1A E2F5 UBE2D3 TCF12 XPO1 RBL1 STUB1 UBE2D1 TRIM33 CCNK CCNC UBA52 AMH CDKN2B GIPC1 NOG COL1A2 FST PPP1CA FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C CCNT1 PPP1CB UBB UBC SP1 UCHL5 CDK9 RPS27A MYOG NEDD8 MEN1 MYOD1 WWTR1 MYF6 TCF4 MYF5 HELLS KLF16 USP9X MMP14 MMP16 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 CYP11A1 FDX1 FDX2 FDXR STARD3 STARD3NL AKR1B1 TSPOAP1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 MDC1 WEE1 YWHAB YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 YWHAZ SFN PIAS4 BRCC3 CCNB1 CDC25C CDK1 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 H2BC26 RFC3 RFC4 H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 CHEK2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 TP53 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase CDK2 BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants FLT3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis GAD1 GAD2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 RAD50 XRCC1 MRE11 BRCA2 FEN1 PARP1 PARP2 LIG3 RBBP8 NBN POLQ VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation PRKCA KDR ITPR1 ITPR2 ITPR3 RASA1 NRAS PLCG1 PRKCZ PRKCB HRAS AHCYL1 PDPK1 SPHK1 CALM1 PRKCD DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism SFTPA2 ABCA3 SFTPD SLC34A2 SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I VWF TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35A1 SLC35B2 SLC35B4 SLC35D1 SLC35C1 SLC35D2 SLC35A2 SLC35A3 SLC35B3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3 CREB3L4 CREB3L1 CREB3L2 MBTPS1 CREB3L3 CREBRF DCSTAMP MBTPS2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism TCN2 CD320 CUBN CBLIF MMAB AMN MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA AREG EGF EGFR PLCG1 EREG BTC EPGN LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations UGT2B7 CYP51A1 GSTA3 GSTA1 COMT CES3 HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CES1 FMO3 MAT1A CYP2C9 NNMT CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 AHCY SLC35D1 SLC35D2 CYP2D6 CMBL ALDH3A1 FDXR POR SULT2A1 CES2 MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 GSTM4 PTGES3 CYP4F3 CYP4F8 GSTK1 CHAC1 PODXL2 CYP27B1 ABHD14B SULT1A1 CYP26A1 SULT1C2 CYP26B1 SULT1B1 CYP24A1 SULT1E1 CYP26C1 CYP21A2 CYP2R1 BPNT2 AHRR BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 CYP4F12 PTGS1 NR1H4 AHR HPGDS CYP4F22 CYP19A1 GSTO1 CYP4F11 AIP NAT1 NAT2 TBXAS1 GSTA2 PAOX SULT1A3 GLYATL3 GLYATL2 ALDH2 GLYATL1 ACSM2A CYP3A4 ACSM5 GLYAT ACSM4 UGT1A9 CYB5B CYP4B1 CYB5R3 CYP27A1 CYP39A1 GSTP1 AOC1 MTRR CYP7B1 CYP7A1 MAT2B CYP8B1 TPST2 TPST1 CYP46A1 RXRA DPEP2 DPEP1 ARNT2 TPMT AS3MT AKR1A1 GSTT2 GSTT1 CYP11A1 ESD GSTT2B UGT1A3 GSTM3 CYP2J2 GSTM2 GSTM1 GSTM5 NCOA1 GSTO2 MAT2A GSTA5 GSTA4 CYP11B2 ARNT CYP4A22 ACSM1 ACSM2B PTGIS MTR NCOA2 POMC GSTZ1 CYP11B1 ADH1C ADH1A UGT1A10 UXS1 ADH4 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 ALDH1A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT2B17 UGDH UGT2B4 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A S100A9 LCN2 S100A8 LTF S100A7 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis ST3GAL4 FUT2 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism SLC26A2 SLC22A5 ABCB4 SLCO1B1 SLCO1B3 ABCD4 SLC2A1 SLC2A2 ABCC2 LMBRD1 ABCB11 OXA1L KGD4 NDUFAB1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 B4GAT1 TIAM2 CHST3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 PTGES3 B3GAT3 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UBE2I PIP5K1C ERCC2 GBA1 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GLYATL3 TP53 GLYATL2 GLYATL1 ACSM2A GNG10 ACSM5 GLYAT ACSM4 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 XDH GNA14 GNG3 GNA15 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 NUP37 PPP1CC PPP2R1B PPP2R1A PPA2 PPA1 RPS27 PPP2R5D DCXR AKR1A1 SORD CRYL1 XYLB IPPK IPMK ISYNA1 IP6K1 INPP1 IP6K2 NUDT3 NUDT4 VAC14 PI4K2B INPP5B MTMR10 NUDT11 PPP2CA NUDT10 PPP2CB MTMR2 MTMR12 INPP5A PIK3C2A IMPA1 PPIP5K1 MTMR4 MTM1 PLCZ1 IMPA2 INPP4A PPIP5K2 FIG4 PLCE1 INPP4B IP6K3 PIKFYVE MIOX INPP5F PI4K2A ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 ATIC OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS CPT2 GLUD1 MID1IP1 GLUD2 KYAT1 SLC25A20 CPT1B RIMKLA GLUL RIMKLB CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ADH1C ADH1A ADH4 RDH11 SIRT5 AKR1C3 MARCKS PRPS2 ALDH1A1 PRPS1 RPEL1 IDI1 MVK RPE SHPK TM7SF2 PGLS PMVK PRPS1L1 SC5D FDFT1 RBKS FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 NQO1 GSTA3 GSTA1 RAP1A PRKACG PRKACA PRKACB RAPGEF3 COMT BLVRB RAPGEF4 BLVRA CA12 CA1 CA3 CA5B CA2 CA5A CA4 CA7 CA6 CA9 CA14 CA13 PLCG2 GCHFR CHRM3 GCH1 SPR PTS PCK2 SLC37A1 G6PC2 G6PC3 RPS4Y2 FBP1 RPS27L FBP2 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 RPS24 B3GNT7 RPS23 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 GCKR GCK HSP90AB1 LYPLA1 CYGB DDAH1 PRKAA2 PRKAG2 PODXL2 ABHD14B SULT1A1 STK11 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 PRKAB2 SULT1A4 SULT4A1 SULT1A2 SULT1C4 MAN2B2 MAN2C1 LBR OCRL NAT1 NAT2 GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM ITPA CAV1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 HAS2 SPAM1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L SEC23A ASPA B3GALT6 B4GALT7 PNMT DDC TH DBH SEC24B SEC24A IQGAP1 PLD1 SEC24D SEC24C WASL TCN2 CD320 FUT3 TPST2 TPST1 NOSIP B3GNT3 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 AS3MT RPL32 GSTT2 HSPG2 RPL31 GSTT1 RPLP1 RPL34 ESD RPL10L GSTT2B GSTM3 RPL8 GSTM2 RPL10A GSTM1 RPL6 GSTM5 RPL7 GSTO2 RPL7A RPL18A MAT2A ACAN RPL36AL GSTA5 GSTA4 LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD RPL23 RPL22 RPL13A RPL9P9 SUMO2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 GPI ADPGK RPL26L1 ENO1 ENO2 ENO3 MRI1 ENOPH1 HK2 BHMT2 ENO4 HK3 BHMT ADI1 TPI1 PGAM1 PGAM2 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 PGK2 PFKL ECSIT GNPDA1 GNPDA2 PFKM PFKP CREBBP SP1 GLYCTK KHK GPT MED19 MED18 MED11 KCNJ11 ABCC8 ADCY9 ADCY4 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 MED21 ADCY6 ADCY5 CDK19 MED13L PRKG2 HEMK2 PLA2G4A GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC ITPR1 CHAC2 GGT3P ITPR2 GGT1 ITPR3 GCLM LRP8 APOB NOS3 CES1 DHFR TK1 GNAS HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC RAB5A KPNB1 TYMS SLC3A2 NSDHL LIPI CYP2D6 LIPH FDXR SULT2A1 STARD3 SLC36A4 ACOT9 STARD4 STARD5 ACOT7 MECR STARD6 STARD7 RUFY1 CH25H PRKD3 SLC6A12 FDX1 SLC7A5 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 CYP2E1 FAR2 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 HSD11B1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA CYP4F3 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE TSPO SPHK2 PTGR1 PTGR2 CYP21A2 AHRR SLC46A1 SAMD8 ECHS1 SGMS1 SGMS2 PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIAS4 VDAC1 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 ABHD4 ABHD3 INSIG2 INSIG1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 PLA2G12A CERS5 GPX1 ALDH1L1 CERS6 DHFR2 GPX4 FAAH2 MTHFR TNFRSF21 MTHFS ALDH1L2 CERS1 MTHFD1 CERS2 MTHFD1L PPM1L MTHFD2 HSD17B14 TPTE MTHFD2L LRP2 SLC25A32 CYP3A4 FOLR2 HSD17B11 SLC19A1 AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 TPH2 MBOAT1 ASMT DDHD2 AANAT MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PITPNB GBE1 CPNE7 PYGM ECI1 GYS2 PHKG1 CPNE6 PHKG2 GDE1 GYG2 ACSM6 CPNE1 EPM2A CPNE3 AKR1E2 PHKA1 PTGDS MFSD2B PHKB PHKA2 ACAD11 ACAD10 PPP1R3C MFSD2A NHLRC1 SACM1L SLC51A SLC51B PISD GALT CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS PANK4 CBR1 PCYT1B PANK2 PCYT1A PANK3 PANK1 STARD3NL DCAKD PLAAT1 PLAAT3 COASY PLAAT2 PPCDC CYP7B1 SLC25A16 NUDT8 PLAAT5 VNN2 PLAAT4 PPCS AKR1D1 ENPP2 GDPD1 ENPP3 ALOX12B GDPD3 SLC25A42 GDPD5 AASDHPPT HSD17B7 CYP7A1 MAT2B ORMDL2 HSD17B1 ORMDL3 HSD17B2 SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CKMT2 CYP8B1 GAMT GATM ETNPPL PLEKHA8 SLC6A7 PNPLA3 SLC6A8 PNPLA6 CKM CKMT1B ACAA2 INPPL1 SLC6A11 MSMO1 CKB CYP46A1 PLB1 ENPP6 SBF1 HADH SBF2 TPTE2 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PLA2G10 GPD1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 CHAT PLD4 PLD6 PLD3 ALDH3B2 EBP CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 ACBD6 ARG2 ACBD4 DGAT2L6 SLC25A2 CRLS1 ACSF2 CYP11B2 PI4KA DEGS1 ALPI DEGS2 PI4KB TNFAIP8 CYP4A22 DBI PCTP ACOXL ABCC3 PLA2G4F ABCC1 PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L PPP1CA NME1 PPP1CB MLXIPL FECH ACADSB ADIPOR1 ADIPOR2 NADK2 ACAD8 TYR UCKL1 DCT UCK2 UCK1 PUDP TK2 TYRP1 SLC5A8 SLC26A11 SLC26A1 ACO1 PLCB4 GCGR GCG SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLC5A6 COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ADSL PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS ADRA2C ADRA2A MT-CO1 B4GALT1 TKT SCO2 KCNG2 MT-CO2 MT-CO3 PPARGC1A PPARGC1B KCNC2 MED16 MED15 MED17 MED12 KCNB1 MED14 MED13 MED10 KCNS3 MED27 MED26 SIRT3 ALDH2 MED23 MED25 MED24 MED20 PPARG PPARA PPARD MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 RORA L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ODC1 ATP5MK COX11 AMD1 ATP5MJ OAZ1 COX14 SAT1 OAZ2 NDUFV3 SRM NDUFV2 ATP5MG OAZ3 MED30 NDUFV1 AZIN2 ATP5MF AZIN1 MED31 AGMAT ATP5ME SMS COA3 COA1 GOT1 UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 G6PC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 DMGDH NDUFB7 NDUFB6 CHDH SARDH COX4I1 NDUFB5 COX4I2 NDUFB4 ALDH7A1 SYT5 NDUFB3 NDUFB2 MLX ETFDH ALDH4A1 NDUFB1 PRODH FOXRED1 PRODH2 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 ARNT NDUFA6 FAHD1 NDUFA3 RRM2B NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 CCNC COX7B COX7C CTSL CAD COX8A DHODH SREBF1 UMPS COX8C COX5B COX5A COX6C GPAM COX6A1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C SAMHD1 VDR ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 PPM1K AUH QDPR IVD IL4I1 HIBCH PCBD1 ASRGL1 GALM RRM2 HGD TAT FAH HPD CARM1 LALBA NOSTRIN PNPO AOX1 XYLT2 XYLT1 B4GALNT2 NAMPT B3GALT2 PIP4K2A B3GALT1 PIP4K2B PIP4K2C FAM20B FUT4 FUT6 FUT5 FUT7 MED1 FUT9 B3GALT5 GALK1 PXYLP1 MED8 B3GAT2 B3GAT1 GALE MED4 MED6 MED7 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD CGA NR1D1 PIP4P1 GCSH SNAP25 GUK1 PAH GCDH HYKK AADAT SLC25A21 CRYM AASS CDA DHTKD1 CYB5A SLC23A2 SLC23A1 CIAO3 CIAO1 AFMID RIDA UROD NUDT13 NUDT12 NDOR1 NADK GNS UROS ALAS2 BCAT1 CYB5R3 DCTPP1 BCAT2 SLC45A2 ALDH6A1 KYAT3 ESRRA HIBADH THTPA NMRK2 TCN1 NMRK1 KMO PYGB COX10 NAXE PYGL PPOX CDK8 RRM1 NAXD HMBS ACMSD LHPP MMS19 MOCS2 MOCS3 RNLS TPK1 MOCOS CIAO2B SLC22A13 GSTP1 DTYMK HAAO GRHPR AOC1 TDO2 AGL IDO2 IDO1 QPRT SLC25A44 SLC25A51 SLC25A19 SLC25A28 SLC25A37 NUBP1 NUBP2 ENTPD2 GPX2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 GYG1 CD38 CPOX GPHN GLRX5 GLDC HOGA1 SLC19A3 SLC19A2 OCA2 SMARCD3 NMNAT3 NMNAT2 NMNAT1 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMT GLRX NADSYN1 NME3 NME4 ALAD DCTD TXNRD1 CMPK1 PGM2 KYNU CTPS2 CTPS1 PGM1 TTR COX7A2L TXN DERA BST1 VNN1 ARNT2 NFYA NFYB NFYC MANBA GAA NME2 BMAL1 CD44 COXFA4 COX7A2 COX7A1 SLC2A3 MAN2B1 POMC NAPRT PDXK GALNS UGT1A10 UXS1 UGT2B28 SLC9A1 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 BCKDK UGT2B15 BCKDHA UGT2B17 BCKDHB UGDH DBT UGT2B4 DLD UGT2B7 LDLRAP1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL LDLR GPIHBP1 MBTPS1 APOC3 ALB MBTPS2 FLAD1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 SERINC4 UCP1 HSD17B10 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA ALOX12 PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 PLCB3 CACNB2 PLCB1 PLCB2 CACNA1D DNM2 TPH1 EPRS1 TRMT112 CYP4F12 RAN ABCC5 ABCB7 NT5E ENTPD1 ENTPD5 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP RBP4 RBP1 LRAT ABO MMAB MTRR RTEL1 CBLIF MMACHC MMADHC INPP5E MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 LPIN2 MGLL LPIN3 PDK4 PEX11A CD36 NCOA2 NCOA6 NCOA3 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 PLIN2 BCO1 VKORC1 AKR1B10 CLPS PNPLA2 RBP2 LRP10 LRP12 PNLIP ADIPOQ DSEL DSE UST CHST15 ZDHHC21 ACSS3 AGPAT2 THRSP GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH TKFC ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 FMO3 NMT1 HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 SEPSECS QARS1 PSTK MARS1 INMT DARS1 SARS1 EEF1E1 AHCY KARS1 CBS IARS1 GNMT CTH SCLY CMBL ALDH3A1 POR CES2 BMX MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 APIP CYP2B6 EPHX1 CYP2S1 CYP4V2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 DUOX2 TSHB INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RPLP0 HSPA9 GSTO1 AIP TALDO1 MTAP GSTA2 AHCYL1 SULT1A3 MMAA MMUT PGD MCCC2 BTD PC PCCA HLCS MCCC1 PCCB ACACB FFAR1 TMLHE SHMT1 BBOX1 ALDH9A1 MTMR1 SHMT2 HMOX2 LETM1 GYS1 RHCE RHD PIK3CB NDUFA5 PTPN13 VAPB PIK3CA PIK3R3 PIK3C3 TRIB3 PIK3R4 PIK3R2 PIK3R1 STXBP1 INS THEM4 CACNB3 PLD2 CACNA1A ACBD5 CACNA1E ACSM1 ACSM2B MTR CALM1 NDUFS3 WDR26 PDHB RMND5B LDHA MPST TSTD1 MAEA SQOR PDPR GADL1 RMND5A SUOX ME1 NEK1 ADO CSAD PDK3 TXN2 DLAT TST PDK2 PDK1 ETHE1 PDHX SLC25A10 PDHA2 CDO1 PDHA1 GLP1R SIRT4 BRIP1 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 CYP11B1 HMMR SEM1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC PRSS3 PDZD11 PLA2G2A HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 CHPF OLAH CHSY1 ELOVL4 CHST11 ACSL1 ELOVL5 CHST12 CHSY3 ELOVL2 CHST13 SCD5 CSGALNACT1 ELOVL3 CHST7 ACSL6 CHPF2 ACSL5 CSGALNACT2 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 GSTK1 ASNS PHYH ACOT8 CHAC1 PIPOX BCS1L GNPAT ACOT2 STX1A ACOT4 COX19 COX17 ATP5MC1 PSMD8 HMOX1 PSMD6 HACL1 PSMD7 HAO1 CYC1 DECR2 PSMD2 HAO2 PSMD3 AKT1 PSMD1 NUP214 EPHX2 IDH1 PRKCA CS PSMA5 PSMA6 COQ2 PSMA3 AMACR PSMA4 DAO PSMA1 PXMP2 PSMA2 ACO2 MAPKAPK2 CROT UBA52 HSCB PSMD12 PSMD11 CACNA1C PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 TIMM21 BAAT UBB PSMB2 SLC25A17 ACOX2 PSMB3 UBC PSMB1 EHHADH AGPS PRSS1 RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PHYKPL ADRM1 CTRB2 PAOX CTRB1 NDUFB8 PSMC5 TAFAZZIN PSMC6 PSMC3 PSMC4 HSD17B4 PSMC1 PSMC2 DDO HMGCL ATP5F1A ATP5F1B IDH3G CYCS SRD5A3 NUDT7 VAPA CRAT IDUA NCAN HEXB HEXA LTC4S BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB HADHB HADHA ACADVL HSP90AA1 CYP17A1 PLCG1 NMT2 POLD1 EP300 RXRA HDAC3 GPS2 RXRB UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 NR1H2 NR1H3 NCOR2 NCOR1 TBL1XR1 FABP6 APOC2 PLIN1 HK1 AKAP5 GNAI1 GNAI2 MVD ST6GALNAC5 ST6GALNAC6 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 NEU1 CHD9 ST3GAL4 SLC17A5 ST8SIA5 ST3GAL5 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 TGS1 CTSA APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins OCLN DSG1 TJP2 DSG2 DSG3 CTNNB1 TJP1 PKP1 CDH1 DSP CASP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model SLC25A14 UCP1 UCP3 SLC25A27 UCP2 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm FOXF1 SHH IHH BMP4 GATA4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis CLTC CLTB CLTA DNASE2 CLVS2 CLVS1 ARF1 CTSZ BLOC1S1 GNS TXNDC5 HGS DNM2 AP4S1 AP4M1 AP1G2 DNAJC6 AP1G1 AP1S2 AP1S1 AP1S3 VAMP7 SH3GL2 AP1M2 HSPA8 AP1M1 VAMP2 AP1B1 VAMP8 APP CHMP2A AP4E1 M6PR ARRB1 AP4B1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SGTA STX5 STX1A VAPA VAMP2 BAG6 SERP1 SEC61G GET1 APP OTOF SEC61B HMOX1 GET3 EMD GET4 CAMLG UBL4A PRNP DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions ZNF217 STRAP HEYL ANGPTL4 TCF3 TGIF2 EED POMT2 POMT1 RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ANG RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ EML4 SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 NEK9 ZWINT NEK6 NEK7 KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 BTK GNGT1 GNG8 GNGT2 GNG10 GNG12 GNG11 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 ADORA2B GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B IL6 PRKAR1A PRKAR2A PRKX GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 DHFR TK1 RB1 CDKN1B RRM2 E2F1 RBBP4 SKP2 CABLES1 FBXO5 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 SOS1 YAP1 HBEGF GFAP SPARC SHC1 PIK3R1 NRAS APH1A ITCH PSENEN NCSTN APH1B PSEN2 PSEN1 GABRG3 APOE GABRG2 GABRB3 GABRB2 GABRB1 NCOR1 CXCL12 ESR1 WWOX ADAM17 SRC NRG1 DLG4 STAT5A NEDD4 GABRQ EGF EGFR GABRA1 UBA52 STMN1 WWP1 ADAP1 CSN2 UBB UBC RPS27A MXD4 HRAS S100B TAB2 EREG NRG3 PIK3CA PGR NRG4 NRG2 BTC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly COL17A1 ITGB4 LAMB3 CD151 ITGA6 PLEC DST LAMA3 LAMC2 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm OSR1 FGF2 FOXC2 FOXC1 BMP4 PAX8 PAX2 LHX1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 GSTZ1 PDP2 DLD FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway CENPX UBA52 MUS81 WDR48 SLX4 EME1 EME2 SLX1B FANCI UBB ATRIP FANCC UBC FANCD2 RPS27A DCLRE1B DCLRE1A FAAP100 UBE2T FAAP24 USP1 POLN FAAP20 FAN1 FANCM RPA1 FANCL FANCA RPA2 FANCB FANCE FANCG FANCF RPA3 ERCC4 ERCC1 ATR CENPS UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HBEGF HSP90AA1 CD9 HSP90AB1 TXNRD1 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family MUC15 MUC13 MUCL1 LYN MUC3A MUC5AC CLEC4C MUC3B CLEC4D MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 CLEC10A CLEC4A CLEC4E CLEC6A SYK FYN PLCG2 MUC12 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs CDC42 CTTN FLNA PPP1R12A PAK1 PAK3 LIMK1 RAC1 MYL12B MYL6 MYH9 MYLK MYH14 MYH11 MYH10 MYL9 NF2 PAK2 PPP1R12B PPP1CB CALM1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 DOCK3 RAC1 NTRK2 BDNF DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD SLC35D1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery SNRPD2 SNRPD1 SNRPD3 SNRPB SMN2 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 SNRPG RPS25 RPS28 RPS29 RPS20 FAU SNRPE RPS21 RPS24 RPS27 RPS23 SNRPF G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase E2F1 CDK2 E2F3 CCNA2 CCNA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes FMO3 CYP17A1 CYP4F22 CYP19A1 TPMT CYP7B1 MAT1A CYP11A1 CYP2U1 CYP1B1 CYP27A1 CYP11B2 AHCY CYP27B1 CYP11B1 TBXAS1 SLC35D1 CYP26B1 GSS OPLAH CYP24A1 CYP26C1 CYP2R1 CYP21A2 GCLC GGT1 GCLM FDXR ACY1 MAOA UGT1A4 FDX1 FDX2 UGT1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1 LHPP SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK PIK3CB SOS1 ALKAL2 ALKAL1 LTK TNK2 PIK3R2 PIK3R1 GRB2 PIK3CA IRS1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 GNG13 CDC42 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 ARHGEF6 GNG7 GNGT1 GNG8 PAK1 GNGT2 GNG10 GNG12 GNG11 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly NDOR1 RTEL1 POLD1 ABCB7 MMS19 BRIP1 ERCC2 CIAO3 CIAO1 NUBP1 NUBP2 CIAO2B VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways RELA NPM1 ITCH NR3C1 IRAK1 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 MED4 MED6 MED7 UBE2N VAV1 MAPKAP1 NEDD4L C4BPA C4BPB PTGES3 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB TAF7L FEN1 UBE2I SUMO1 C1QA C1S ELOB ELOC RBX1 VHL RNMT CCNH POLR2A ISCU POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 KPNA7 KPNA4 KPNA5 GBP1 KPNA3 CDK8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 PPP1CC PML DYNC1LI1 DYNC1LI2 RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 CD33 CHUK TJP1 DYNC1I2 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 BRD4 RPS18 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A TLR6 IKBKE IRF7 RAN NEK2 PDIA3 TUBB VPS36 VPS25 CBX1 SNF8 CHMP1A UBE2V1 CUL5 UBA7 UBA6 UBA5 UBR4 PAK2 IGF1R CAV1 UBA3 UBA1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A FXYD4 FXYD3 HYOU1 FXYD2 FXYD1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 NRP1 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 ARID4B SAP30 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD TAB3 TAB2 NFKBIB ELK1 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 SAP30L IFNA17 BAG2 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 PARP8 TUFM GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 DNAJC10 NMT1 VPS33B RIPK3 RAB5A KPNB1 TLR4 BCAP31 FNTA CHMP4C CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TAF9B KPNA2 MAP3K7 H2AC1 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA SCAP MAVS TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 CRNKL1 CDC40 ATP6V1H DHX9 CSTF3 CSTF2 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 DOCK2 CAMK2G HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 EFTUD2 PPP1CB CWC22 PAPOLA TXNL4A SNRPN ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 ACOT2 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B HSP90AA1 EGFR RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 CTSL ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 ATP7A ATP8B4 ATP8B3 ATP8B2 CAMK2B ATP8B1 SRI ATP4B CAMK2D ATP4A FXYD4 FXYD3 CAMK2A FXYD2 FXYD1 FXYD7 FXYD6 ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP7B CALM1 CAMK2G PDZD11 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants FLT3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GNAI3 GNAI1 GNAI2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development CLTB YAP1 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 MAG TEAD1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 POU3F1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 MBP ADGRV1 TYROBP DOCK1 MPZ ADGRG6 HMGCR ERBB2 PRX PMP22 SOX10 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM POU3F2 ANK1 SEM1 FYN CLTC CYP51A1 CLTA SREBF2 AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA2 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 SCD5 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 NAB1 MSI1 COL6A2 NAB2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 EGR2 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 DRP2 ROCK1 ROCK2 CNTN1 UTRN DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 HDAC2 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 WWTR1 YES1 SMARCA4 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CD4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism SLC26A2 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC CUBN AMN ABCD4 LMBRD1 GSS OPLAH GCLC GGT1 GCLM ACY1 SFTPD PPM1K AUH IVD HIBCH FMO3 GALM ADAMTS13 MAT1A POMT2 CYP2U1 G6PC3 POMT1 CYP1B1 POMGNT1 B4GAT1 AHCY DAG1 SLC35D1 LARGE1 APRT PNP ACACA HPRT1 FDXR ADA MAOA GALK1 CHSY1 GALE PRELP CHST6 OMD FDX1 KERA FDX2 NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 ACAT1 SFTPA2 MGAT2 PAPSS2 MOGS SDC4 SDC2 SDC3 B3GAT3 CYP27B1 SGSH CYP26B1 CYP24A1 CYP26C1 CYP21A2 CYP2R1 NAGLU B4GALT1 MAN1B1 ECHS1 GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 IDH1 UBA52 CYP4F22 CYP19A1 UBB TALDO1 UBC TBXAS1 RPS27A MMAA MMUT SFTPC PAH SRD5A3 MCCC2 BTD PC GBE1 PCCA HLCS MCCC1 GYS2 PCCB GYG2 EPM2A GNS PPP1R3C NHLRC1 CYP27A1 GALT B3GALT6 SLC37A4 B4GALT7 MMAB IDUA NCAN HEXB HEXA BGN DCN BCAN MTRR VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB GYG1 CYP17A1 GYS1 CYP7B1 PGM1 TCN2 CD320 CBLIF MMACHC MMADHC MUC13 G6PC1 SFTPB SFTA3 CHST14 SFTPA1 TPMT DCXR HSPG2 CYP11A1 GAA ACAN CYP11B2 LUM AGRN FMOD ABCA3 GALNT12 SEMA5A DPAGT1 SPON2 SEMA5B SPON1 THSD7B MPI MTR ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 CSF2RB THSD7A CSF2RA ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 ADAMTS12 DPM1 DPM2 THSD1 POMC ALDOB DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 SI MUC1 LCT MUC2 ADAMTS19 HGSNAT GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 CYP11B1 NEU1 SSPOP KHK MUC5B MUC20 MUC21 GALNS LFNG ST3GAL3 MPDU1 CTSA NUS1 UGT1A4 PMM2 GFPT1 DOLK SLC34A2 UGT1A1 BCKDK BCKDHA BCKDHB MC2R DBT DLD SLC25A15 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling LIFR CRLF1 TYK2 IL6ST STAT3 CBL SOCS3 IL6R LIF IL11 OSM IL6 OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA STAT1 CTF1 PTPN11 CLCF1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling FGF18 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 SPRED2 SPRED1 FGFRL1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding CLTC CLTB FTH1 CLTA FTL CTSZ BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 GNS SNAPIN AP3S1 TPD52 CLINT1 DNM2 AP4S1 AP4M1 AP1G2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 M6PR GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 STX4 SNAP23 DNASE2 CLVS2 IGF2R CLVS1 DTNBP1 ARF1 GOLGB1 NAPA RAB5C GBF1 TGOLN2 AP3B1 TXNDC5 HGS OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 APP CHMP2A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NEDD4L SERPINE1 FURIN PARP1 HDAC1 MAPK1 SKIL MAPK3 ATP1B4 SKI CDK8 NCOR2 SMAD2 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC E2F4 CCNT2 PPM1A E2F5 UBE2D3 RBL1 TGIF1 UBE2D1 TGIF2 TRIM33 CCNK CCNC UBA52 CDKN2B COL1A2 CCNT1 TFDP1 TFDP2 UBB UBC SP1 RPS27A CDK9 EP300 JUNB RNF111 MEN1 WWTR1 USP9X BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT FKBP1A NFATC2 NFATC3 PPP3CA PPP3CB NFATC1 PPP3R1 CALM1 PPIA GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI3 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 MCRIP1 SNAI2 KMT5A TGIF2 EED RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB CANX MGAT1 PRKCSH MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SNAPC5 SNAPC1 SNAPC2 SNAPC3 CCNT2 SNAPC4 ZNF143 PCF11 POU2F1 POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E SRRT POLR2F POLR2G POLR2H TAF9 POLR2I POLR2J POLR2K POLR2L TAF13 SUPT5H GTF2F1 TAF11 GTF2F2 ELL CDK7 CCNT1 TAF8 SUPT4H1 TAF6 TAF5 NCBP1 NCBP2 SP1 INTS1 INTS3 INTS2 CDK9 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 GTF2A1 ICE1 GTF2A2 ICE2 GTF2B SSU72 GTF2E1 GTF2E2 NABP2 NABP1 PHAX ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB1 DEFB104B DEFB109B DEFB136 DEFB135 DEFB134 CCR6 DEFB133 DEFB132 DEFB108B DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion CACNA1D GNG13 GNB2 GNAQ KCNJ11 GNB1 ABCC8 GNB4 GNB3 STXBP1 INS GNB5 ADCY8 GNGT1 ADCY6 ADCY5 GNGT2 RAP1A SLC2A1 PRKACG SLC2A2 PRKACA ADRA2C PRKACB RAPGEF3 SYT5 FFAR1 ADRA2A RAPGEF4 CACNB3 GNA14 CACNA1A CACNA1E STX1A GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 KCNG2 AKAP5 GNAI1 GNAI2 PRKCA IQGAP1 CD36 SNAP25 GNAS KCNC2 GCG CACNA1C CHRM3 GLP1R KCNB1 KCNS3 VAMP2 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CACNA2D2 MARCKS CACNB2 PLCB3 PLCB1 PLCB2 GNG10 ACSL4 ACSL3 GNG12 GNG11 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones HSPA5 MBTPS1 ATF6B MBTPS2 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM6 IRF1 NCAM1 TRIM5 IRF2 TRIM2 TRIM3 GBP1 CIITA HLA-H TRIM68 TRIM62 HLA-B TRIM46 HLA-C TRIM48 TRIM45 HLA-F TRIM35 HLA-G TRIM38 HLA-E OAS2 TRIM31 TRIM34 MAPK1 FCGR1BP IFI30 RAF1 TRIM29 TRIM26 TRIM22 MAPK3 MT2A TRIM17 SOCS1 PTPN1 IFNGR1 TRIM14 VCAM1 IFNGR2 TRIM10 PTPN11 SP100 CD44 MID1 YBX1 IRF8 B2M IRF6 IRF3 IRF9 SMAD7 CAMK2B PIAS1 HLA-A CAMK2D SUMO1 TRIM21 GBP5 CAMK2A GBP2 GBP6 GBP4 GBP3 TRIM25 IRF7 FCGR1A CAMK2G PRKCD IFNG PTAFR OASL OAS1 OAS3 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 JAK2 HLA-DRB4 JAK1 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 PML HLA-DQB1 ICAM1 SOCS3 PTPN6 IRF4 IRF5 GBP7 TRIM8 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) ATP6V0D1 SRPRB TPP1 PREB CXXC1 CXCL8 HDGF PPP2R5B KDELR3 SHC1 CREB3L3 ADD1 DCTN1 HSPA5 NFYA NFYB NFYC ATF6 CEBPB HERPUD1 CEBPG CCL2 ASNS SEC31A EIF2S2 EIF2S1 ERN1 EIF2S3 DDIT3 CREB3 CREB3L4 CREB3L1 ATF3 CREB3L2 ATF4 CALR EXTL2 MBTPS1 CREBRF DCSTAMP ATF6B MBTPS2 PLA2G4B EXTL3 HYOU1 KHSRP GSK3A EIF2AK3 DIS3 ACADVL PDIA6 DNAJB11 DCP2 SERP1 PARN WFS1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 TLN1 EXOSC8 DNAJC3 EXOSC3 EXOSC2 EXOSC1 CUL7 FKBP14 IGFBP1 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 HSP90B1 CTDSP2 SRPRA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema KLKB1 F2 F12 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A CPSF4 CHTOP CPSF7 CPSF1 FUS ALYREF CPSF3 CPSF2 SRRM1 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 CDC40 DDX39A ZC3H11A SARNP DHX9 DDX39B CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 UPF3B MAGOHB HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SLU7 SF3B4 FYTTD1 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 CASC3 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG13 GNB2 GNB1 GRIK3 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) YAP1 CREBBP DPPA4 DPPA2 LEUTX KDM4E EP300 TPRX1 TPRX2 ZSCAN4 TEAD4 TUT7 TUT4 DUX4 TP53 TPRXL DUXA DUXB AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC NQO1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 PPM1K SDSL AUH IVD QDPR SERINC2 IL4I1 PSPH HIBCH SERINC5 PCBD1 ASRGL1 SERINC4 HNMT SEPHS2 KGD4 RARS1 SECISBP2 MAT1A LARS1 HGD NNMT TAT FAH EEFSEC HPD AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 RPS17 SARS1 HSD17B10 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT SLC3A2 RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 SLC36A4 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 APIP RPS20 SLC6A12 HAL FAU RPS21 CARNMT1 RPS24 SLC7A5 UROC1 RPS23 AMDHD1 HDC CARNS1 FTCD CGA FMO1 ACAT1 PAPSS2 PAPSS1 ASNS TPH1 PIPOX EPRS1 ECHS1 PSMD8 PSMD6 PSMD7 HAO1 PSMD2 PSMD3 PSMD1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO GCSH PSMA5 IYD PSMA6 DUOXA1 PSMA3 DUOXA2 PSMA4 DUOX2 PSMA1 DAO TSHB PXMP2 PSMA2 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A MTAP SLC25A12 AGXT PHYKPL SLC25A13 ADRM1 PAOX PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DDO TP53 CAV1 GCDH PAH HYKK TPH2 AADAT ASMT SLC25A21 AANAT CRYM AASS DHTKD1 MCCC2 AFMID MCCC1 RIDA BCAT1 AGXT2 BCAT2 SLC45A2 ALDH6A1 KYAT3 HIBADH KMO OGDH FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA ACMSD TMLHE SHMT1 BBOX1 ALDH9A1 PNMT HAAO GRHPR DDC TDO2 TH IDO2 DBH IDO1 SLC25A44 MTRR DLST SLC44A1 GLDC HOGA1 OCA2 AMT TXNRD1 KYNU ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM OAZ3 AZIN2 AZIN1 AGMAT CKMT2 GAMT SMS GATM SLC6A7 GOT1 SLC6A8 CKM CKMT1B SLC6A11 CKB RPS27 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 DMGDH RPLP1 RPL34 CHDH RPL10L SARDH RPL8 ALDH7A1 RPL10A RPL6 RPL7 ARG2 ALDH4A1 PRODH SLC25A2 RPL7A RPL18A PRODH2 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 MTR RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MRI1 ENOPH1 BHMT2 BHMT OAT ADI1 GLS2 GOT2 PYCR1 MPST TSTD1 PYCR2 PYCR3 SQOR GLS GADL1 GLUD1 SUOX GLUD2 ADO KYAT1 CSAD RIMKLA TXN2 GLUL TST ETHE1 RIMKLB SLC25A10 CDO1 GSTZ1 ACADSB ACAD8 TYR SIRT5 DCT SEM1 TYRP1 GPT BCKDK BCKDHA BCKDHB DBT DLD SLC25A15 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) OPN1MW OPN1LW DHRS3 OPN1SW RBP3 AWAT2 RLBP1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle CS ISCA2 ISCA1 ACO2 FXN ACAT1 LYRM4 SDHAF2 SDHAF3 SDHAF1 CSKMT SDHAF4 IDH2 SDHC SDHD SIRT3 SDHA SDHB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation MAPKAPK3 MAP3K7 IRAK1 UBE2V1 MAPKAPK2 TRAF6 MAPK14 MAPK11 IRAK2 TAB1 TAB3 TAB2 NOD1 MAP2K6 NOD2 UBE2N IKBKG MAP2K3 RIPK2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs HACD1 ACSBG1 TECR HSD17B3 SLC27A3 HSD17B12 ACSBG2 HACD3 HACD2 HACD4 ELOVL1 ELOVL4 ACSL1 ELOVL5 ELOVL2 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER PCNA PARP1 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 DDB2 POLD2 POLE RFC2 RFC1 PARP2 RPA1 CHD1L RPA2 DDB1 XPA POLE4 CUL4A RPA3 RBX1 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 GCN1 RPS19 RPS18 EIF2AK4 RPS3 RPS2 RPS11 IMPACT RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 TRIB3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A CEBPB RPL6 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPL37 ATF3 ATF4 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking WNT5B WNT5A PORCN WNT7B WNT16 WNT1 WNT7A SNX3 WNT3A WNT9A WNT3 WNT8A WNT8B WNT10B WNT9B WNT6 WNT4 WNT2 WNT2B WNT10A VPS29 WNT11 VPS35 WLS VPS26A TMED5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB2 VDAC1 MAIP1 PARL AFG3L2 LETM1 SMDT1 YME1L1 PMPCB PMPCA MICU3 AKAP1 MICU2 MICU1 MCU PHB1 SLC8B1 SLC8A3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PDE6G GNB1 GNGT1 APOA2 APOA1 APOA4 HSPG2 APOE SDC4 SDC2 SDC3 LPL RBP4 RDH12 OPN1LW RBP1 LRAT LDLR AGRN STRA6 GPIHBP1 GPC1 APOC3 APOC2 RDH5 GPC3 RLBP1 LRP8 GPC2 GPC5 GPC4 GPC6 OPN1MW APOB RPE65 SDC1 CALM1 PRKCA RDH8 OPN1SW GUCY2D GUCA1B GUCA1A GUCA1C LRP1 GUCY2F NMT1 RETSAT GRK1 APOM GRK7 FNTB RHO BCO2 CNGA1 BCO1 GNAT1 RCVRN AKR1B10 CAMKMT CLPS RBP2 RGS9BP SLC24A1 SAG LRP10 NMT2 LRP12 RBP3 PPEF1 PNLIP HSD17B6 METAP1 METAP2 CNGB1 HSD17B1 FNTA AKR1C1 TTR RDH11 RDH10 ABCA4 AKR1C4 RDH16 AKR1C3 SDR9C7 DHRS3 MYO7A DHRS9 PRKCQ LRP2 PLB1 CYP4V2 AWAT2 PDE6B PDE6A CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CALM1 CAMK2G ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS PLA2G2D OSBPL10 PLA2G2E MBOAT1 PLA1A PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLAAT3 PLA2G2A OSBPL8 PLA2G1B OSBPL5 LPCAT4 LPCAT3 PLA2G2F PLA2G4A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS SOS1 HBEGF TGFA AREG EGF EGFR NRAS EREG BTC EPGN DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 MAP3K7 IRAK1 UBE2V1 TRAF6 MAPK9 IRAK2 TAB1 MAP2K7 MAPK10 MAPK8 TAB3 TAB2 NOD1 NOD2 UBE2N IKBKG RIPK2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 RUVBL1 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 POLR2A POLR2B POLR2C POLR2D NHP2 POLR2E POLR2F ANKRD28 POLR2G NOP10 POLR2H POLR2I POLR2J POLR2K PPP6C POLR2L PPP6R3 BLM RTEL1 CHTF8 DAXX ATRX WRN PRIM2 PRIM1 H2AX POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC2 TERT RFC1 H3-3B STN1 RPA1 TEN1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ RPA3 H2BC15 CCNA2 CCNA1 H2BC11 DNA2 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BRD7 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SMARCE1 ACTB ARID2 PBRM1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 BCL2L1 NLRP1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors PRKCA TSPAN7 AP2A1 GRIA1 GRIA2 PRKCB GRIP1 NSF PICK1 PRKCG GRIP2 GRIA3 GRIA4 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia F9 F10 F8 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 RPS6KA2 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle ARHGAP26 AKAP12 HINT2 VANGL1 ARHGAP32 PIK3R2 PIK3R1 RHOD ESYT1 ACTN1 LMNB1 TOR1AIP1 ARHGAP12 DBN1 CPNE8 STEAP3 ANKFY1 GOLGA8R MOSPD2 ADD3 ARHGAP1 SLC4A7 ARHGAP39 ARHGAP5 ARHGAP35 FILIP1 STBD1 EMD LBR TMPO VRK2 PLXNA1 LEMD3 DEPDC1B PLXNB1 CAPZB VAMP3 EFHD2 RAB7A ARHGAP17 ARHGAP21 PAK6 LMAN1 WHAMM PGRMC2 PAK5 RACGAP1 VAPB DIAPH1 DIAPH3 CAV1 MCAM CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway RELA MALT1 CASP8 NFKB1 IL1B PYCARD INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLST DLD SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function CDH24 ADAM33 ADAM19 CTNNB1 CDH11 JUP ANGPTL4 CTNND1 CDH8 CTNNA1 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance APOA1 HDLBP CUBN AMN MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase LMNB1 NCAPG2 SMC4 SMC2 NCAPH2 NCAPD3 MCPH1 NUP205 POM121 NUP107 NUP188 KMT5A AAAS NUP160 POM121C ARPP19 NUP42 NUP85 TPR ENSA NUP62 BANF1 NUP88 USO1 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB2A NUP155 NUP133 RB1 NUP210 VRK1 LEMD2 NUP153 NUP93 NUMA1 NUP50 NUP35 NUP54 RAB1A RAB1B GOLGA2 NUP37 BLZF1 PPP2R1B H2AX CNEP1R1 PPP2R1A H2AB1 MASTL H2AC19 GORASP2 H2BC26 GORASP1 H2AC14 PPP2R2D H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 MAPK1 PPP2CA PPP2CB LPIN1 LPIN2 LPIN3 NUP214 PRKCA PLK1 CCNB1 CDK1 SET EMD LEMD3 CCNB2 NEK9 NEK6 NEK7 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency OTC TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes PCNA PLK3 CDKN1A PRMT1 PLAGL1 NPM1 RGCC PLK2 CDK2 BTG2 CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 E2F4 CNOT9 CNOT11 E2F7 E2F8 RBL2 ZNF385A RBL1 SFN CCNB1 CDC25C CDKN1B AURKA ARID3A CDK1 BAX E2F1 CARM1 TFDP1 CCNE2 TFDP2 CCNE1 CPAP PCBP4 EP300 CNOT6L CCNA2 TP53 CCNA1 GADD45A CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CDC6 ORC5 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 UBE2W H2BC3 PEX14 H2BC1 USP7 HLA-B USP5 UBA1 RNF20 UBE2K CDC34 VCP UBE2J2 UBE2Q2 UBE2R2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA UBE2G1 UBE2G2 UBE2C CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS UBE2S WAC UBA52 PRKDC CTR9 RTF1 BCL10 UBE2Z TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 UBE2E3 PEX2 UBB UCHL3 UBC RPS27A UBE2T OTULIN UBA6 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP9X H2BC11 UBE2H UBE2B UBE2N RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 PAX5 ELF1 ELF2 CBFB BLK HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly APOA1 PRKACG A2M PRKACA PRKACB ABCA1 ZDHHC8 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 SOS1 PIK3R1 NRAS FGF20 MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 PPP2CA FGF18 PPP2CB FGF10 PTBP1 HNRNPM HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 BRAF UBB PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling SOS1 STAT5A STAT5B CBL PIK3R1 NRAS UBA52 CDKN1B GRAP2 PTPRJ CSK BCL2L11 FLT3 UBB PTPN11 UBC RPS27A AKT2 GRB10 HCK SYK HRAS LCK FYN SLA ABL2 SLA2 SOCS2 SOCS6 FOXO3 SH2B3 FLT3LG AKT1 GAB2 PIK3CA AKT3 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions HHIP BOC GAS1 SHH IHH DHH CDON PTCH1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle TRAK1 TRAK2 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol RXRA NCOA2 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 HSD3B7 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) LTC4S PTGR1 HPGD ALOX5AP ALOX12 ALOX5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 FCGR1BP PSMD13 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CD207 MRC2 ADRM1 PSME2 MRC1 PSMC5 PSMC6 SEM1 PSMC3 PSMB10 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 FCGR1A PSMD1 PSMB8 PSMB9 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing FURIN PCSK6 NGF PCSK5 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases ARSB ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD STS ARSA SUMF2 SUMF1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD GCLC GCLM PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PIP5K1C CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 DISEASE%REACTOME%R-HSA-1643685.19 Disease SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L SLC5A1 SLC5A2 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 RNF185 SLC26A3 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 EXOC1 GBF1 POMT2 CYP2U1 POMT1 CYP1B1 POMGNT1 B4GAT1 DAG1 LARGE1 FGFR2 OGG1 RAC1 VAV3 UBE2N VAV1 VAV2 CHST3 ACAT1 DCTN1 PTGES3 MAPK8 BCL2L11 DNAJA2 FKBP4 HSPA1B BAD IFNGR1 IFNGR2 B3GAT3 IKBKB SQSTM1 CYP27B1 MYD88 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FEN1 UBE2I SUMO1 UBE2D2 ELOB ELOC RBX1 VHL RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B TP53 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 ACTG1 PPP1CC PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DVL1 DVL2 DVL3 RPS27 ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CARS1 DYNLL1 RANGAP1 DYNLL2 EEF1G DCXR CHUK DYNC1I2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 TAOK1 TFG MPRIP FGFR1OP2 SND1 ZC3HAV1 EIF2AK3 NOX4 ATIC DUSP8 DUSP9 MRAS KDR FAM114A2 PORCN MCL1 QKI NF1 KIAA1549 DUSP10 ESRP1 BIRC6 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 AGTRAP AP3B1 SHOC2 AGGF1 NFKB2 CPSF6 SI TENT4A LCT SPRED3 CTDP1 SPRED2 ELL SPRED1 CCNT1 MYO18A SUPT4H1 ELOA LRRFIP1 NELFB KANK1 RRBP1 ETV6 WDCP NELFCD NELFA FAM131B GOLGA4 NELFE BIN2 STRN SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 LFNG JAG1 DLL1 SKP1 CUL1 NTRK3 NTF3 NEURL1B HES5 MIB2 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 RAF1 IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 JAK3 SIGMAR1 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 G6PC3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X RPS15 IGLV3-25 RPS14 IGLV3-27 IGKC RPS17 IGKV1-39 RPS15A RPS16 IGLV3-21 IGKV1-33 RPS19 RPS18 BRD4 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 RPS10 STAT2 RPS13 IGLC6 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 UBE2L6 RPS24 HERC5 RPS23 OGN NOTCH2 NOTCH3 NOTCH1 NOTCH4 HBEGF GCKR GCK HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E SFTPA2 RNF213 ATG7 SEC31A RPTOR CALR MLST8 EIF4E TSC2 MRC1 GRSF1 MTOR FKBP1A TLR6 AKT1S1 CYFIP1 NCKAP1 BRK1 PDIA3 S100A1 VPS36 CYBA VPS25 CBX1 SNF8 BCR CHMP1A LMO7 RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 NCKAP1L WASF1 PAK2 WASF2 CAV1 ERBIN BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 TGFB1 TGFBR1 TGFBR2 LMNB1 TIRAP SEC23A B3GALT6 B4GALT7 WIPF1 WIPF2 WIPF3 FCGR1A SEC24B SEC24A IQGAP1 MAP3K11 SEC24D SEC24C DUSP16 FGFR1 TMPRSS2 WASL SRPK2 GALNT1 AXL TCN2 CD320 RCC1 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 TPST2 TPST1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B MASP1 XRCC6 XRCC4 XRCC5 LIG4 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A ACAN RPL36AL LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 HDAC4 RPL27 HDAC2 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 AMER1 RPL35A RPL23A GSK3B CSNK1A1 RPL3L AXIN1 RPL27A RPL22L1 APC RPL26L1 OPN1SW ENO1 CDC73 SKIC8 CTR9 RTF1 ALDOB LEO1 PAF1 HHAT SHH PGK1 DHH MAP2K4 CGAS CREBBP IRAK4 SP1 KHK TLR10 TLR5 AREG NFE2L2 BCL2L1 PTPN6 MAPK9 IRAK2 MAP2K7 CAMK4 NTF4 NTRK2 BDNF TAB3 TGFA TAB2 NFKBIB FOXO3 ELK1 PTK2 IFNA5 EREG IFNA4 BTC IFNA7 MC2R EPGN IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 KCNJ11 ARIH1 ABCC8 IFNA13 ABCC9 IFNA14 ADCY9 IFNA16 IFNA17 ADCY4 BAG2 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 FGR GGT5 GSS OPLAH GCLC ITPR1 ITPR2 GGT1 ITPR3 GCLM NOS2 P2RX7 EML4 P2RX4 GNAS VPS33B CORO1A HGS RAB5A KPNB1 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 UPK1A EPCAM FDXR SLC6A19 SLC36A2 SLC6A14 FDX1 FDX2 SLC7A7 SLC7A9 DUSP6 DUSP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B CYP21A2 STT3A STT3B MAN1B1 ECHS1 RETREG1 KEAP1 H2AC17 AGK H2AC12 TRIM25 CFTR STAM CYP4F22 CYP19A1 H2AC25 H2AC21 WDR48 IFIH1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TBXAS1 KAT2B PIK3CD KAT2A RNF135 TAF9B SFTPC MAP3K7 GBE1 GYS2 H2AC1 CDC25A GYG2 EPM2A STAM2 PPP1R3C VCP NHLRC1 CLINT1 TNKS FOXO4 GALT CYP27A1 NLRP3 RIPK1 SUDS3 SMAD2 SMAD4 SMAD3 ESR1 NFKBIA SCAP MAVS MDM2 TAB1 RIGI PTEN ARRB1 ARRB2 TRAF2 MERTK H2BC18 TRAF3 TRAF6 BECN1 CYP7B1 NOD1 NOD2 TNKS2 TAF10 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 AQR CRNKL1 DPEP2 CDC40 DPEP1 DHX9 CSTF3 CYP11A1 CSTF2 PCBP1 PCBP2 CSTF1 CYP11B2 DHX38 SYMPK RBM10 HNRNPL HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 IRF4 PRPF6 BCL2A1 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CPSF4 CPSF1 FUS ALYREF CPSF3 CCR5 CPSF2 CXCR4 CWC15 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 SLC35D1 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC27A4 KIT RBPJ B4GALT1 TXNIP SFN EZH2 CLDN1 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 PMS2 RICTOR MBD3 STAT1 GATAD2B GATAD2A CCNT2 CDC25C MSH2 KMT2D FOXO6 FOXO1 MED30 MED31 G6PC1 NFKB1 SFTPB SFTA3 SFTPA1 FASLG ITGA4 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A CCNK MUC5AC MUC3B CCNC ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 SH3GL3 EPS15 SH3GL2 SH3GL1 YES1 EEF2 CTSL SYVN1 RELA FZD8 ARPC1B ARPC1A NPM1 ITCH KLC1 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH ACTR3 ACTR2 NR3C1 TRAK1 KIF5B IRAK1 NCKIPSD ACY1 IL6 TAF4B YWHAE PRR5 DPY30 CHD4 PPM1K YWHAQ AUH IVD YWHAG HIBCH C4A YWHAH TBP EED GALM TAF9 TAF1L MTA2 TAF15 TAF12 TAF13 TAF11 SOD2 REST TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 MAML2 MAML1 DNAJC3 JUNB MED1 GALK1 MED8 GALE MED4 MED6 MED7 MAML3 MAPKAP1 NEDD4L PRDX2 PRDX1 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 PLK2 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 CD19 V2-8 V1-20 ASH2L V1-9 TAF7L V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QA C1S V4-6 V4-2 V4-1 ISCU SNAP25 SYT1 MSH3 PTPN12 NRBP1 TLR8 PAH KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ABL1 GNS CDK8 CDK5 WDR5 PYCARD CLEC5A GYG1 HDAC5 RAB5B RAB5C HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 RBBP5 RBBP7 TXNRD1 PML PGM1 HDAC10 TTR HDAC11 FCGR2A TWIST1 TXN PARP1 BST2 PRMT1 GP1BA HBB CD33 MLH1 TJP1 GAA CDK5R1 ESR2 NR4A1 CASP1 CD300A THBS1 ERBB2 HES1 DDX3X POMC PHB1 ARAF PEBP1 CSK JAK2 MARK3 HGSNAT FGB DYNLT1 BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 GALNS SLC9A6 SLC9A9 HCK SYK LCK UGT1A4 FYN F9 F10 GGCX PROS1 F2 GAS6 UGT1A1 BCKDK BCKDHA BCKDHB DBT DLD CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 CUBN AMN APOA1 SAR1B AP2S1 AP2B1 P4HB PRF1 ICOS STAT5A IL10RA ZC3HC1 CD3G BTRC ADAMTS13 MTA1 MTA3 FCGR3A MYH2 MYO10 MYO1C APRT PNP HPRT1 ADA PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX FZD5 FZD4 FZD6 PIM1 GBP2 GBP4 IKBKE IRF7 GP1BB F12 F11 GP5 GP9 KLKB1 BAG4 RAN SLC20A2 NEK2 WNT3A LRP5 KREMEN1 TUBB KREMEN2 DKK1 DKK2 LRP6 DKK4 AKAP9 ABCA4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 SUGT1 IGF1R CALM3 CALM2 CEP43 KDM7A ATP1B3 ATP1B2 ATP1B1 RBP4 RDH12 OPN1LW RBP1 NAPEPLD LRAT STRA6 FXYD4 MMAB FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 MTRR ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ANO10 CLCN6 SUN2 CBLIF MMACHC MMADHC NRG3 NRG4 NRG2 NTHL1 NEIL3 NEIL1 PIK3AP1 SIKE1 CSF2RB CSF2RA CD36 STAT5B GRB2 ARID4B CTBP2 CTBP1 SAP30 DNMT1 NCL CEBPD PDGFRB DNMT3B DNMT3A SAP30L RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 PARP9 IL17F IL17A PARP14 PARP8 GEMIN2 TUFM GEMIN4 CRK GEMIN5 GEMIN6 FMO3 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 FADD P4HA3 CD14 GSDMD DNAJC10 NMT1 GSDME C1QBP MAT1A RIPK3 IL18 IL1A IL1B TLR4 BCAP31 AHCY FNTA TICAM1 CHMP4C CHMP4B CHMP4A LY96 MLKL MAOA CHMP2B CHMP2A TRADD HMGB1 CASP8 CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 PAPSS2 PAPSS1 SDC4 SDC2 SDC3 SGSH NAGLU GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 SLC5A5 LYN PIK3CG PIK3R6 PIK3R5 BTK ARF1 NPLOC4 RPLP0 JAK1 IL10 MSN TALDO1 TYK2 PPIA ALK AHCYL1 LMNA KPNA2 MMAA MMUT MCCC2 BTD PC PCCA HLCS MCCC1 PCCB SPCS3 SPCS2 SPCS1 SEC11A SEC11C FOXM1 GNAZ CD163 RHBDF2 ADORA2B JAG2 ADAM17 RDH5 RLBP1 CYFIP2 GJA1 ZMYM2 FGFR3 GYS1 TPM4 TPM3 RNF43 KLB FLT3 IRS1 IRS2 EIF4E3 PIK3CB PPM1B FGF1 FGF2 FGF3 EIF4G3 FGF4 EIF4G2 FGF6 NCK1 FGF7 FGF9 AKT2 HRAS WASF3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 TLR9 PIK3C3 SOS1 RAC2 SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 NRAS FGF20 PPFIBP1 ATP6V1H MAPK1 FGF23 FGF22 ELMO2 MAPK3 PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 UNC93B1 TLR3 ABCA3 CAMK2B CAMK2D SRC CAMK2A NRG1 MTR ZAP70 CALM1 DOCK2 CAMK2G ANAPC15 DOCK1 ANAPC16 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CCNB1 CDC23 TRAT1 UBE2S RPS6KB2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 CYP11B1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 APP RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 HGF RAD9B RHNO1 ATR RAD9A CLIP1 SLC25A15 CPS1 ARG1 ASL NAGS KDELR1 SERPING1 ASS1 GCC2 NMRAL1 OTC PDGFB CLU HSPA5 CTSG COG1 TLR1 S100A9 S100A8 LTF TLR2 F8 CD9 S1PR1 GOLGA2 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST PRIM2 CUX1 CD4 PRIM1 POLA1 POLA2 ACACA TRIP11 PDGFRA GTF2A1 CHSY1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN TCF7L2 CDKN1A HDAC1 CDKN2A CDC25B CCND1 SIN3A CDK2 CTNNB1 MET CEBPB TNRC6C MOV10 ACOT2 STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 GRPEL1 YWHAB ELAVL1 PSMD8 HMOX1 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 IDH1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 PEX19 SRD5A3 C3 FURIN SLC67A1 CPSF7 ROCK1 ROCK2 CUL3 SRRM1 VIM HNRNPC RBMX AP1G1 ZBP1 AP1S2 AP1S1 AP1S3 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 HLA-A CD8B PACS1 IDUA ELMO1 NCAN CD28 HEXB OPN1MW HEXA BGN PALS1 DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB UVRAG MAP1LC3B TRIM27 HSP90AA1 EGF CBL EGFR CYP17A1 CDC37 PLCG1 CDKN1C RB1 CDKN1B CCND3 FZR1 FNTB CCND2 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 NMT2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX LIG1 MSH6 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 SFPQ IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 TAL1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ABCA1 ABCG8 ABCG5 NCOR2 NCOR1 TBL1XR1 DPAGT1 ST6GALNAC2 MPI HK1 GNAI3 GNAI1 GNAI2 ALG8 ST6GAL1 ALG9 ALG6 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 DHDDS DPM1 DPM2 DPM3 RFT1 ST6GALNAC3 ST6GALNAC4 SLC24A1 GNE NEU1 ST3GAL4 SLC17A5 ST3GAL1 AVP ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 SLC4A1 PMM2 ABCA12 SLC4A4 BSG GFPT1 SLC12A6 DOLK SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling TYK2 CANX IL6ST STAT4 JAK2 IL27RA EBI3 STAT3 IL12A JAK1 IL12RB2 STAT1 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions SLCO4A1 SLCO1A2 SLCO2B1 SLCO4C1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 AVP SLCO2A1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling JUN RELA RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 VAV3 PPP3CA PPP3CB PRKCQ PPP3R1 VAV1 UBE2N VAV2 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 NFATC2 V1-11 V1-16 V1-13 MAPK8 IKBKB V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 PSMD14 NFATC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 PSMC3 AHCYL1 PSMC4 PSMC1 PSMC2 PAK2 RASGRP4 MAP3K7 CARD11 MALT1 NFKBIA TAB1 TEC TRAF6 PLCG1 PIK3CB HRAS PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 NFKB1 NRAS MAPK1 CHUK FCER1G MAPK3 CALM1 UBE2D1 FCER1A LAT2 BCL10 MS4A2 TXK MAP2K4 FBXW11 MAPK9 SYK MAP2K7 SEM1 MAP3K1 FYN MAPK10 TAB3 SKP1 TAB2 FOS CUL1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NEDD4L TGIF1 UBE2D1 TGIF2 TRIM33 PARP1 HDAC1 UBA52 MAPK1 SKIL MAPK3 UBB ATP1B4 SKI UBC SMAD2 NCOR2 RPS27A SMAD4 SMAD3 NCOR1 SMURF2 SMAD7 SNW1 RNF111 WWTR1 PPM1A UBE2D3 USP9X RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF RUNX1 CCND1 BRD2 RUNX3 EP300 KRAS HDAC4 CBFB TGFB1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response MYH9 CD163 RHBDF2 FURIN ADAM17 IL10 MAPK14 PLK2 IL6 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle TFRC KIF14 KIDINS220 VANGL1 MUC13 PIK3R2 ARHGAP5 TMEM59 PIK3R1 ARHGAP35 TXNL1 ALDH3A2 PKP4 RASAL2 STIP1 PLXNA1 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 STMN2 EPSTI1 PTPN13 RND1 PLEKHG5 FRS2 FAM135A GRB7 VANGL2 FLOT2 DSP CAV1 RRAS2 CCDC88A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere H2BC9 ACD H2AZ2 TINF2 POLR2A H4C9 TERF1 POLR2B H2BC8 TERF2 POLR2C H2BC5 POLR2D H2BC3 POLR2E H3-4 POLR2F H2BC1 POLR2G POT1 POLR2H TERF2IP POLR2I POLR2J H2AC20 POLR2K POLR2L DAXX ATRX H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle CUL3 PLIN3 RAB9A RAB9B HGS VHL CCNE1 RHOBTB3 LRRC41 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLRMT POLG2 RNASEH1 TOP3A POLG TWNK MGME1 EXOG SSBP1 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance ALDOB COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 COL17A1 ITGB4 COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 PLEC COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 LOX COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 CTSS PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB LAMB3 P4HA1 LAMA3 P4HA2 P4HA3 LAMC2 COL1A1 COL1A2 ADAMTS14 MMP9 P3H2 P3H1 P3H3 PXDN MMP3 SERPINH1 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis GGPS1 LSS SQLE IDI2 ACAT2 MVD IDI1 MVK PMVK FDFT1 FDPS PLPP6 HMGCS1 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome TAF7L CCNT2 TAF4B ELOB ELOC RNMT CCNH POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L RNGTT GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 SUPT5H GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 TAF10 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 CD8B ATP6V1H TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion TRIT1 YRDC TRMU TRMT61B OSGEPL1 GTPBP3 TRMT10C MTO1 PRORP HSD17B10 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 POMT2 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs RBM8A ISL1 ETF1 GSPT2 GSPT1 UPF3A USP33 UPF2 LDB1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH HOXA2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 ZSWIM8 RPL34 MSI1 RPL10L RPL8 RPL10A RPL6 RPL7 LHX3 RPL7A RPL18A RPL36AL LHX2 RPL36 LHX4 RPLP2 RPL35 LHX9 RPL38 RPL37 COL4A5 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A ROBO2 RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CASC3 PSMB4 PSMB5 UBB PSMB2 PSMB3 NCBP1 SLIT1 UBC NCBP2 PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 BTK CFL1 ACTB MYO5A SYK PAK1 NCKAP1L WASF1 PTK2 WASF2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion PPIA CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA RELA XRCC6 XRCC5 NFKB1 DHX9 CTNNB1 CHUK IKBKB RIPK1 MYD88 ZBP1 TLR3 TREX1 DDX41 DTX4 TBK1 IRF3 NFKBIA STING1 NLRP4 TRIM32 TRIM21 TRIM56 IRF7 NLRC3 IFI16 CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F UBA52 POLR3G PRKDC DHX36 POLR3H POLR2K POLR2L POLR3K MRE11 NFKB2 RIPK3 NKIRAS1 LRRFIP1 NKIRAS2 IKBKG UBB CGAS AIM2 CREBBP UBC TICAM1 RPS27A EP300 STAT6 NFKBIB POLR1C POLR1D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways RELA MAP3K7 NFKB1 HSP90AB1 ITCH PANX1 CHUK MAP2K6 NLRP3 IKBKB IRAK1 CARD9 TAB1 TXNIP HMOX1 TNFAIP3 MAPK12 MAPK13 CASP1 CASP2 P2RX7 PYCARD TRAF6 BIRC2 BIRC3 NLRC4 CYLD NFKB2 NOD1 NOD2 IKBKG NLRP1 RIPK2 AIM2 BCL2 UBE2V1 BCL2L1 AAMP MAPK14 IRAK2 MAPK11 APP MEFV PSTPIP1 TAB3 TAB2 SUGT1 CASP8 TXN CASP4 CASP9 UBE2N BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport KIF28P KDELR1 KDELR3 KIF5C KIF21A KIF21B KIFAP3 KLC1 KLC4 KLC3 KLC2 RINT1 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 KIF3B SEC22B KIF3C RAB6B KIF5B KIF5A KIF18B KIF4B KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 BICD2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 PAFAH1B3 ARF5 NAPA GBF1 NAPB NBAS RAB6A RAB1A STX18 RAB1B NAPG GALNT1 BNIP1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 GALNT2 ARCN1 ZW10 KIF26A KIF26B RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 ACTR1A ARF1 DCTN2 CAPZA1 DCTN3 RACGAP1 ARFGAP1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 TUBB2B TUBB2A TCP1 CCT6B TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 UBC TICAM1 RPS27A TLR3 TBK1 IRF3 TRAF3 OPTN UBA52 IKBKE IRF7 TANK UBB ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP CHTF8 PRIM2 PRIM1 POLA1 DSCC1 POLA2 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 CHTF18 RFC2 RFC1 STN1 TEN1 CTC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis MAPK1 CTSG TRIM27 SFPQ RNF213 GSK3A MAPK3 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CREBBP BHLHE40 RBM4 DBP TFEB CRY2 CRY1 CIPC PER2 PER1 RORC PER3 RORA NR1D1 BMAL1 CRTC1 KMT2A SIK1 CLOCK NPAS2 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R4 GNG13 KCNJ2 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 SCNN1G SCNN1D SCNN1B SCNN1A TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 OTOP1 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis CHST15 CSPG4 CHST3 CHPF NCAN CHSY1 CHST11 BGN CHST12 CHSY3 DCN CHST13 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 UST CSPG5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs MON1A TRAPPC6A MON1B DENND1C TRAPPC6B DENND1B GDI1 DENND1A ULK1 RAB8B DENND2D TRAPPC10 RAB14 DENND2C DENND2B DENND2A RAB3IL1 GDI2 RAB7B DENND3 RAB21 ALS2CL RAB27B CHML RAB12 RAB13 TRAPPC4 CHM RAB9A RAB6B RAB9B RAB39A YWHAE AKT1 ALS2 RAB3A RAB31 RAB5B RAB5C RAB3IP RAB6A RAB1A RAB1B TRAPPC1 RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 GAPVD1 RAB7A RIC1 RAB32 RAB35 RGP1 RAB27A RAB38 AKT2 DENND6B RIN3 RAB3GAP2 RAB8A TRAPPC2L DENND6A RAB10 RIN1 RIN2 RAB3GAP1 RAB18 TRAPPC2 TRAPPC3 ANKRD27 DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B AKT3 TRAPPC8 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling TNFSF10 TNFRSF10B TNFRSF10A CASP10 CASP8 TNFRSF10D FADD CFLAR INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling TYK2 IL6ST JAK2 STAT3 CBL JAK1 SOCS3 IL6R STAT1 PTPN11 IL6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network SCOC SYS1 GCC2 GCC1 RAB43 GOLGA1 ARFIP2 RHOBTB3 COG8 COG7 COG6 NSF COG5 COG4 COG3 COG2 COG1 ARL1 VTI1A PLIN3 RAB9A RAB6B RAB9B RABEPK M6PR NAA30 IGF2R NAA35 NAA38 VAMP4 NAPA NAPB TGOLN2 TMF1 STX16 RAB6A NAPG STX10 ARFRP1 VPS51 GOLGA4 VPS53 VPS52 STX6 VPS54 VAMP3 RIC1 RGP1 USP6NL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY2 LEFTY1 SMAD4 SMAD3 CRIPTO3 FURIN DAND5 PCSK6 CFC1 CER1 NODAL GDF1 CRIPTO MAPK1 FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C FOXO3 MAPK3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MT1G MT1H MT1X MT4 MT1B MT3 MTF1 MT1E CSRP1 SNCB MT2A MT1A MT1M MT1F DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines SAT1 PAOX PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 POLE FEN1 RFC2 RFC1 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 APEX1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis ARV1 GGPS1 CYP51A1 LSS SREBF2 SQLE DHCR7 IDI2 ACAT2 MVD EBP LBR HSD17B7 DHCR24 PLPP6 NSDHL MSMO1 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC6A20 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling IFNA2 ADAR IRF1 IRF2 IFNA8 XAF1 IFNA13 HLA-H IFNA14 IFNA16 IFNA17 HLA-B BST2 HLA-C HLA-F HLA-G HLA-E OAS2 IFITM3 IFITM2 IFNA10 IFIT5 IFI35 IFNA21 IFIT3 IFNB1 IFIT2 EIF2AK2 ISG15 RSAD2 IFI27 STAT1 SOCS1 PTPN1 IP6K2 PTPN11 EGR1 IFI6 IFITM1 ISG20 IRF8 IRF6 IRF3 IRF9 IFNAR1 SAMHD1 HLA-A GBP2 IRF7 PSMB8 ABCE1 KPNA1 UBA52 OASL OAS1 OAS3 RNASEL JAK1 KPNB1 USP18 UBB IFIT1 UBC TYK2 MX2 RPS27A MX1 STAT2 SOCS3 PTPN6 IRF4 IRF5 IFNA5 IFNA4 IFNA7 IFNA6 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ACE2 FURIN ANO1 TMPRSS2 ANO10 ANO8 ANO9 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib ERBIN HSP90AA1 ERBB2 CDC37 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT SLC24A1 RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL3 PSMA7 PSMB6 PSMB7 HECW1 KLHL12 PSMB4 PSMB5 DACT1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 DVL1 PSMC4 PSMD8 DVL2 PSMC1 PSMD6 DVL3 PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis TYRP1 SLC45A2 TYR OCA2 DCT SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants FLT3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN APH1A FGD1 PSENEN FGD2 GNA13 NCSTN FGD3 APH1B PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ITGB3BP ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 SQSTM1 YWHAE CASP2 TRAF6 UBA52 BEX3 UBB UBC RPS27A TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 CASP3 TIAM2 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G2D PLA2G2E PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 PLAAT3 PLA2G2A LPCAT1 PLA2G4A PNPLA8 PLA2G4F PLA2G12A TMEM86B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 PLB1 LPCAT3 PLBD1 LPCAT2 PLA2G2F MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation YAP1 GLI3 HEY1 HES1 BGLAP HEY2 ABL1 RB1 WWTR1 SRC YES1 MAF HDAC3 COL1A1 SATB2 MAPK1 HDAC6 SP7 UCMA MAPK3 CBFB ZNF521 AR CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins EPB41L3 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 EPB41L1 STX1A SHARPIN SYT9 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 CASK NRXN2 GRIN2A LIN7A DLG2 LIN7C DLG3 LIN7B DLG4 PDLIM5 NLGN4Y NLGN4X SYT10 SYT12 APBA1 SYT1 DBNL GRM1 GRM5 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 FGF18 FGF1 FGF2 FGF4 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs CDC42 RAC1 IQGAP1 IQGAP2 IQGAP3 CTNNB1 CDH1 MEN1 CALM1 CLIP1 CTNNA1 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling CLTC CLTB TIAM1 CLTA AP2A1 AP2A2 ARHGEF7 ARPC1B NGEF ARPC1A AP2M1 RHOA KALRN APH1A PSENEN ROCK1 NCSTN ROCK2 APH1B PSEN2 CLTCL1 ARPC4 ADAM10 ARPC5 PSEN1 ARPC2 ARPC3 DNM1 ACTR3 ACTR2 ARHGEF28 SDC2 CDC42 AP2S1 AP2B1 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 GRIN2B EPHA1 EPHA3 GRIN1 MYL9 EPHA10 EPHB6 EFNB2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 EFNA5 EFNA4 CFL1 GIT1 EFNA1 EFNA3 WASL EFNA2 ACTG1 MMP9 ACTB MMP2 NCK2 EPHA2 ITSN1 RASA1 SDCBP YES1 PAK1 PAK3 LIMK2 RAC1 HRAS LIMK1 MYL12B FYN VAV3 MYL6 MYH9 MYL12A MYH14 MYH11 MYH10 PAK2 PTK2 VAV2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE5A MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 SLC35A1 CHST10 DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A4 FKRP CRPPA POMGNT1 B4GAT1 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs ALK HIP1 PRKAR1A CLTC STRN PPM1B BIRC6 NPM1 EML4 FN1 EIF2AK3 BCL11A SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) TIAM1 SOS1 FRS3 CDK5 NTF3 PIK3R1 NRAS PLCG1 SRC DOCK3 RAC1 HRAS GRIN2B NTF4 NTRK2 BDNF GAB1 FRS2 PIK3CA CDK5R1 PTPN11 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CB JAK2 PIK3CD LYN GAB1 PIK3R1 PIK3CG PIK3CA PIK3R5 EPO EPOR IRS2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS HRAS RAPGEF1 SOS1 JAK2 SHC1 LYN NRAS CRKL EPO VAV1 EPOR IRS2 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases UBC GYG1 RPS27A SLC37A4 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 EPM2A PPP1R3C NHLRC1 GAA G6PC3 UBB GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism GCKR GCK PPP2R5D G6PC1 PC PRKACG PRKACA PRKACB PCK1 PPP2CA PPP2CB SLC37A4 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK2 PGK1 SLC37A1 NUP37 PGK2 G6PC2 PFKL G6PC3 FBP1 GNPDA1 FBP2 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP CITED2 ARNT CA9 HIGD1A VEGFA EPAS1 EP300 HIF1A EPO ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MRAS PPP2R5B PPP2R5A PPP2R5D PPP2R5C NRAS PHB1 MAP3K11 ARAF SHOC2 RAF1 JAK2 MARK3 BRAP KSR1 PPP1CB PPP1CC BRAF PPP2R1B PPP2R1A PPP2CA PPP2CB CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS MAP2K1 MAP2K2 CALM1 CAMK2G PPP2R5E ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism CYP4B1 FAAH DPEP2 DPEP1 ALOX15 LTA4H PTGES3 PTGDS CYP4F3 CYP4F8 CYP2J2 PRXL2B PLA2G4A GGT5 PTGES PTGR1 CYP4A22 PTGR2 GGT1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 ALOX15B LTC4S PON3 HPGD PON2 PON1 EPHX2 GPX2 HPGDS ALOX5AP MAPKAPK2 CBR1 CYP4F22 CYP2C9 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 CYP4F11 SLC27A1 TBXAS1 PTGES2 ALOX12 GPX1 GPX4 CYP8B1 FAAH2 AKR1C3 AWAT1 ALOXE3 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 MAPK1 MAPK8 IFNB1 MAP3K5 MAP2K6 MINK1 MAPK3 TNRC6C TNIK MOV10 BMI1 AGO3 CBX6 AGO4 RING1 MAP4K4 AGO1 MDM2 TNRC6A MDM4 TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 EED CDKN2D CDKN2C MAPKAPK2 UBA52 CDKN2B E2F1 RBBP4 E2F2 MAPKAPK5 E2F3 EZH2 CDK6 TFDP1 RBBP7 TFDP2 CDK4 H2AX MAP2K3 UBB MAP2K4 H2AB1 MAPKAPK3 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 MAPK9 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 H2BC17 MAP2K7 H2BC12 H2BC13 MAPK10 H2BC14 H2AJ H2BC15 FOS TP53 H2BC11 TXN KDM6B H3C15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors APOA1 SSC5D S100A9 PRDX1 CD5L APOB CD36 SAA1 HMGB1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin TPGS1 TPGS2 TUBB8 AGBL5 AGBL4 AGBL1 AGBL3 TUBA1C AGBL2 TUBA1B TUBB8B TUBA1A LRRC49 VASH2 VASH1 TUBB2B TUBB2A TTLL7 TTLL6 TTLL5 TTL TTLL4 TUBB6 TTLL3 TUBB3 TTLL2 TUBA3E TUBB1 TTLL1 SVBP TTLL9 TTLL8 TUBA3D AGTPBP1 TUBA3C TTLL10 NICN1 TTLL13 TTLL11 TTLL12 TUBB4B TUBB4A DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions CLEC5A SOS1 SIGLEC14 PIK3R2 PIK3R1 HLA-B KLRK1 HLA-C KIR3DS1 NRAS PLCG1 BTK HLA-E GRAP2 NCR2 KIR2DS2 SIRPB1 KIR2DS4 KIR2DS5 CD300LB TREM1 SIGLEC16 SIGLEC15 CD300E LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 PRIM2 PRIM1 POLA1 H2AX POLA2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L POLE H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 CDC45 KPNA6 MCM10 DBF4 RPA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors STAB1 APOB SPARC STAB2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCB6 ABCB4 SEL1L KCNJ11 ABCC8 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 ABCD4 VCP ABCC2 ABCA1 ABCG8 ABCC6 ABCG5 LMBRD1 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 ABCA3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ABCA12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora EPM2A UBC GYG1 RPS27A PPP1R3C NHLRC1 UBA52 GYS1 UBB THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism SDS SDSL RIDA P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway HLA-H CTSV B2M HLA-B CTSL HLA-C CTSS HLA-A HLA-F HLA-G HLA-E LNPEP GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TOPORS SUMO2 UBE2I SUMO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling CBL UBA52 FGF20 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF7 FGF9 MKNK1 SPRY2 FRS2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence RPS6KA1 JUN CXCL8 RELA HMGA2 H1-1 H1-0 H1-3 LMNB1 IFNB1 CABIN1 H1-2 MAP2K6 H1-5 H1-4 HIRA UBN1 EP400 ASF1A MDM2 MDM4 IL6 EED CDKN2D CDKN2C RB1 HMGA1 CDKN1B FZR1 E2F1 IGFBP7 RBBP4 E2F2 MAPKAPK5 E2F3 CDK6 IL1A TFDP1 RBBP7 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TXN KDM6B H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 VENTX TERF2 H2BC8 H2BC5 H2BC3 MAPK7 STAT3 H3-4 H2BC1 NFKB1 CDKN1A POT1 TERF2IP H2AC20 CDKN2A MAPK1 CDK2 MAPK8 MAP3K5 CEBPB MINK1 MAPK3 ETS1 ETS2 EHMT2 EHMT1 ERF TNRC6C TNIK MOV10 ID1 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 MAP4K4 TNRC6A TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 MAPKAPK2 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 EZH2 KAT5 NBN MAP2K3 UBB MAP2K4 MAPKAPK3 UBC SP1 RPS27A MAPK9 MAPK14 MAPK11 MAP2K7 RAD50 MAPK10 TP53 FOS CCNA2 ATM CCNA1 RPS6KA3 RPS6KA2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease HRAS SOS1 FGFR4 GAB1 FRS2 PIK3R1 NRAS PIK3CA PLCG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 PRDX1 RELA MAFG PGD NFKB1 ABCG2 NQO1 CDKN2A GSTA3 GSTA1 SRXN1 CHD6 CCL2 ABCF2 PRKAA2 SOD3 G6PD SQSTM1 ATF4 GCLC TKT ABCC3 MYC ABCC1 GCLM PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B IDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF PSMA2 UBA52 PSMD12 PSMD11 ME1 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 BACH1 UBB TXNRD1 PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 PSMB1 BCL2 PDGFA RPS27A MAFK SLC7A11 AREG NFE2L2 BCL2L1 EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TXN NOTCH1 CUL1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane MTMR3 MTMR8 MTMR9 RAB14 PIK3R2 MTMR6 PIK3R1 PIP5K1A PIP5K1B MTMR14 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B INPP5J INPP5K PI4K2A PTEN MTMR1 PIP5K1C INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RAB4A RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 INPPL1 RUFY1 PIK3CA PIK3R3 SBF2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate CHIA AMY2A AMY1A MGAM AMY2B TREH AMY1B SI AMY1C LCT CHIT1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) GP5 SERPINA5 GP9 SERPING1 KLKB1 CD177 THBD GP1BA KNG1 C1QBP FGB F3 FGA VWF FGG PF4 F2R A2M PRCP TFPI F13B PRTN3 SERPINC1 F7 F13A1 F9 PROC F10 SERPIND1 F5 PROS1 PF4V1 F8 F2 SERPINE2 GP1BB F12 F11 PROCR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination SRSF6 CLP1 SRSF7 MAGOH ZNF473 SNRPD3 SNRPB SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF7 CPSF1 ALYREF DDX39B CPSF3 CSTF3 CSTF2 CPSF2 SRRM1 CSTF1 DHX38 SYMPK UPF3B MAGOHB RNPS1 PCF11 WDR33 LUZP4 POLDIP3 SRSF1 SLU7 CSTF2T U2AF1 FYTTD1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SRSF11 NUDT21 CASC3 PAPOLA LSM10 NCBP1 LSM11 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SNRPG SRSF2 SRSF3 SNRPE EIF4A3 SRSF4 SNRPF SRSF5 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 SLIT1 SLIT3 DCC NTN1 NELL2 SLIT2 ROBO1 SRC DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling AIP ARNT2 PTGES3 ARNT AHRR HSP90AB1 AHR STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 RAF1 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 TRPM1 SRI TRPM2 TRPM7 TRPM8 TRPM5 WNK1 TRPM6 TRPM3 WNK2 TRPM4 WNK3 TRPC7 TRPC5 MCOLN3 TRPC6 RYR1 TRPA1 RYR2 TRPC3 RYR3 TRPC4 UNC80 TRPC1 TRPV2 TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 STOM NEDD4L SGK1 CALM1 UBA52 WWP1 UBB UBC RPS27A OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System SEL1L ERLIN1 ERLIN2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 UBE2V2 RAC1 VAV3 COPS5 UBE2N VAV1 VAV2 ADAR SOS2 DCTN6 DCTN5 DCTN1 DCTN4 HSPA1L HSPA2 CAPZA3 MAPK8 BCL2L11 CAPZA2 ACTR10 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 UBE2I SUMO1 UBE2D2 UBE2D3 ELOB ELOC RBX1 EPAS1 CUL2 HIF1A VHL POLR2E POLR2F POLR2H POLR2K POLR2L KRT1 ACTB FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B TP53 FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 SPHK1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 TCP1 BTNL2 XDH MT2A CCT8 TUBB4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 DSC1 NUP50 NUP35 NUP54 NUP37 ACTG1 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DSN1 DIAPH1 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 RHOA KIF2A BIRC5 EVL KIF2C KIF2B CHUK DYNC1I2 IP6K2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE EIF2AK3 CENPS CRCP MCL1 POLR3GL POLR3A POLR3B VEGFA POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IL22 NFKB2 CD274 IL2RG LRRFIP1 FCN2 BIN2 FCN3 CRP COLEC10 SKP1 CUL1 SLC15A4 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 CA1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 PRKRA IGKV4-1 TARBP2 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM LAMA5 SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 BRWD1 IGLC3 BLNK IGLC1 VTN IGLC2 JAK3 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 BRD4 IGLC7 IGHV3-53 IGKV5-2 STAT2 IGLC6 IGKV1-5 IMPDH1 IMPDH2 PDCD1 LIMK1 EEF1A1 MYH9 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 IL23R FBXO9 IL13RA2 IL13RA1 HLA-H IL4R WSB1 FBXO2 IL23A HLA-B FSCN1 HLA-C NDN ATG14 LIF NANOG HLA-F IGHE HLA-G HSP90AB1 HLA-E OPRD1 OSM RNF126 CDC34 BATF HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 PRKAA1 ATG7 PRKAA2 CAB39 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 CD207 CALR FBXL4 MLST8 DZIP3 RNF220 EIF4E DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 MTOR LRRC41 VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 LAMTOR2 UBE2G2 LAMTOR1 PSMB8 PSMB9 LAMTOR3 KLHL9 SPSB2 CYFIP1 NCKAP1 SPSB1 KBTBD6 NCF1 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 BRK1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z STBD1 FBXO22 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 RAPGEF1 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 RAB7A TRAIP RNF41 KLHL42 UBE2V1 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 ABL2 FBXO40 NCKAP1L BTBD1 LONRF1 WASF1 UBE2F PAK2 RAG2 UBE2H RAG1 KLHL25 WASF2 UBE2B IL32 ZBTB16 RASGRP4 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 BAIAP2 FBXO31 KLHL20 UBE2W UBOX5 ABI2 UBE2U RNF182 UBA3 ABI1 UBE2O TPP2 UBA1 BLMH UBE2K TGFB1 UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 LMNB1 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP IL1RL2 PJA1 IL36A TAPBP IL36B TRAF7 IL36G UBE2R2 IL36RN SEC22B IL1F10 THOP1 TRIM50 SEC23A MGRN1 ASB13 ASB14 ASB11 CLEC10A RNF6 CLEC4A ASB12 WIPF1 CLEC4E RNF7 WIPF2 CLEC6A ASB17 WIPF3 DHX58 RNF4 RNF125 TAX1BP1 ASB18 RNF216 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 TNFRSF6B HECTD1 EDA HECTD2 TNFRSF13B HECTD3 TNFRSF11B ASB10 EDA2R TNFSF13B FCGR1A TNFRSF17 SEC24B TNFRSF8 TRIM41 ARHGAP45 TNFSF11 SEC24A TNFRSF4 ERAP2 EDARADD RNF25 TNFSF18 FBXL19 IQGAP1 TNFSF14 PLD1 ERAP1 TNFSF15 FBXL15 IQGAP2 FBXL16 CD70 TNFRSF9 FBXL13 EDAR FBXL14 FBXL12 TNFSF6 TRIM39 TNFSF4 LTA ASB8 JUP CD27 ASB9 LNX1 TNFSF9 TNFRSF25 ASB6 ASB7 TNFSF8 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 ARHGAP9 SEC24C ASB1 WASL PTPRZ1 PAG1 WAS STOM PAK3 MYO9B COLEC12 MAP2K1 COLEC11 HSP90B1 ITGAV NCAM1 FTH1 MASP1 FTL ITGB5 XRCC6 XRCC5 PDCD1LG2 B3GNT3 SPOP ITGAX PIAS1 SUZ12 GSK3B GPI ABCE1 HK3 KLRK1 PGAM1 KIR3DS1 PRKDC DHX36 FCER1A LAT2 BCL10 NCR2 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E LPO NKIRAS2 MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 BCL2 TLR10 TLR5 ALPK1 LRRC14 NLRX1 NFE2L2 BCL2L1 PELI3 BTLA PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 JUN IFNA2 IFNA8 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 OAS2 IFNA10 IFNA21 IFNB1 PTPN22 EIF2AK2 ISG15 CD209 NOS1 APEH FGR STIM1 ORAI2 PECAM1 ORAI1 ITPR1 ITPR2 ITPR3 APOB NOS2 NOS3 MME P2RX7 P2RX1 IST1 KPNB1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 RPN2 TUSC3 PRKCSH RPN1 MAGT1 LTA4H ATF6 GOLGA7 OST4 LGMN DDOST LPCAT1 TMEM258 DAD1 OSTC CANX STT3A STT3B PTGS2 ALOX5 KEAP1 TRIM25 RNF123 GATA3 TNFRSF12A TNFSF12 SIAH2 TNFRSF13C TNFRSF11A CD40LG CYLD LTBR LTB IFIH1 TRIM4 IKBKG TOMM70 RIPK2 OSBPL1A PIK3CD PRKN RNF135 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 SMAD3 CXADR SMURF2 SMAD7 NFKBIA MAVS TAB1 RIGI PTEN TNFAIP3 CD74 SLC44A2 GLIPR1 JAML CD99 TRAF2 TRAF3 TRAF6 BIRC2 BIRC3 USP14 BECN1 NOD1 NOD2 USP18 ORMDL3 PTGES2 TNIP2 INPPL1 EIF4A3 ALOX15 PLD4 PLD3 DHX9 ALDH3B1 PCBP2 DEGS1 HNRNPF HNRNPA2B1 ILF3 MYO5A RAB27A THOC5 CEACAM1 ZEB1 IRF4 PPIE CCR5 FPR2 YBX1 SNRPA1 ANXA1 PTAFR MMP3 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA IRAK3 EBI3 MEF2C IFNLR1 B4GALT1 IL20 IL25 IL26 IL24 IL27 IL11 IL19 IL16 IL17RE OSMR IL17RB TXNIP IL31 IL17C IL11RA IL7 IL7R IFNL2 IFNL1 IFNL3 SFN COL1A2 EZH2 KCNAB2 CASP10 FAAP100 FAAP24 FAAP20 FANCM CTLA4 FANCL FANCA FANCB FANCE FANCG FANCF RICTOR STAT1 RORC RORA PDE12 OASL OAS1 OAS3 RNASEL BLK KMT2C FOXO1 SOCS3 NDUFC2 FBXO32 NFKB1 PIN1 FASLG ITGAL TRIM63 ITGA4 TNFRSF18 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 IL2RA NCR3 CD200R1 HCST MUC12 LILRA6 MUC15 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 PTPN4 NCR3LG1 LAIR2 MICA MUCL1 MUC3A MICB MUC5AC NPDC1 MUC3B GLYCAM1 LILRB1 KIR3DL1 LGALS3 KIR3DL2 CFP LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 MUC1 CD8A MUC2 KLRF1 CD300C CLEC4G KLRB1 MUC7 KIR2DL1 MUC4 KIR2DL2 MUC6 KIR2DL3 MUC16 KIR2DL4 CD300LD MUC17 KLRC1 CD300LF MUC19 CD300LG CD160 CRTAM MUC5B MUC20 ULBP1 MUC21 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 WWTR1 YES1 EEF2 SMARCA4 MLEC CTSV CTSL CTSK GBP7 TRIM8 TRIM6 YAP1 TRIM5 TRIM2 TRIM3 CSH1 RELA XAF1 CIITA TRIM68 TRIM62 TRIM46 TRIM48 ARPC1B TRIM45 ARPC1A NPM1 TRIM35 TRIM38 TRIM31 TRIM34 ITCH KLC1 IFITM3 KLC4 IFITM2 KLC3 IFIT5 KLC2 ARPC4 IFI35 ARPC5 IFI30 ARPC2 IFIT3 ARPC3 IFIT2 TRIM29 NF2 ACTR3 TRIM26 ACTR2 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR RAB9B KIF5B IRF8 IRAK1 KIF5A IRF6 NCKIPSD IRF9 SAMHD1 HLA-DOA HLA-DOB LAG3 IL2 CTSO IL3 CTSF IL6 MGST1 CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG CSF1 C4A EED CAT RETN SOD2 FUCA2 KRAS MMP1 MMP2 DNAJC3 JUNB RNF111 PRKCB CST3 PRKCQ CRKL MAPKAP1 NEDD4L CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 NFATC2 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI CDK13 C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A ASH2L C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 CD46 C1QB TEAD2 C1QA C1S C1R TEAD3 TEAD4 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC ICOSLG SNAP25 RAB3A DNAJC5 IL1RN WWP1 IL18RAP IL1R2 IL4 TOLLIP PTPN20 PTPN23 IL18BP IL13 IL1RAPL1 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 CSF2 PTPN7 PTPN5 IL18R1 PTPN2 CNPY3 TLR8 CTSB FKBP5 KPNA7 KPNA4 KPNA5 GBP1 CSF1R KPNA3 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 FANCC PYGL MMP25 TIMP2 OLR1 SERPINB3 BCL6 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 GSTP1 AGA AOC1 AGL ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B WDR5 RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RNF34 RAB5B NLRC4 RAB5C BRI3 HVCN1 GPR84 RAB6A RBBP4 TXNDC5 TRAPPC1 RBBP5 RAB4B PTPRB PTPRC NIT2 RBBP7 ITGAM ITGB2 FCAR ALAD FCGR3B PGM2 ACP3 SNAP29 PML PGM1 RNASET2 TNFRSF1B PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 SOX2 CPPED1 RAB10 NFASC TSPAN14 FCGR2A RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 TWIST1 TXN CHIT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PRG3 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 LIFR CD47 CD44 KCTD6 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 LAIR1 SMURF1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CASP1 CD93 CASP2 CD300A IRAG2 OPRM1 ATAD3B OSCAR TYROBP DOK3 COPB1 IFNG ADGRG3 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 POMC CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 CSK JAK2 NAPRT ADGRE3 HGSNAT FGB DYNLT1 ATP6AP2 FGA PLAUR MMP8 MMP9 FGG CHI3L1 PDXK CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN PROS1 F2 CLTC CLTA CXCL8 AP2A1 CXCL2 AP2A2 AP2M1 CCL11 CCL3L3 CCL5 NPC2 CCL4 CCL3 CCL2 SAR1B CCL19 CCR1 AP2S1 CCL22 CCL20 CXCL10 AP2B1 P4HB POU2F1 LBP VASP STAT5A IL10RA ITK TRAC CD3G FLNA CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 FCGR3A MYH2 MYO10 MYO1C AMPD3 APRT PNP PPP3CA PPP3CB PPP3R1 NFATC1 DNM2 EGR1 JUND FOSB GBP5 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 SLA SLA2 SOCS2 SOCS6 SH2B3 IKBKE IRF7 TANK ACTR1A NEK2 CEP290 NFATC3 TUBB DCTN2 DCTN3 MEFV PSTPIP1 SUGT1 CALM3 CALM2 ATP8A1 IL34 GAB3 ATP11B ATP11A CARD11 MALT1 ATP8B4 RELB CLEC7A CARD9 MAP3K14 GBP6 ANO6 CENPX KIF23 KIF20A DGAT1 FABP5 PRL SNCA DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 SIKE1 IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R TNF CEBPD STAT6 POLR1C POLR1D AGPAT2 GM2A ARSA ASAH1 PSAP TKFC MBL2 GLA IL17RC IL17RA IL17F IL17A CRK UBE2L3 FADD CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 IL1A IL1B PELI1 TLR4 GSN FNTA TICAM2 TICAM1 PKP1 LY96 SDCBP MAOA HMGB1 CASP8 CASP5 CASP4 DSP IRF1 IRF2 DSG1 NCSTN ADAM10 PSEN1 FBXL18 FBXL7 DNM1 FCER2 DNM3 MAPK12 MAPK13 SDC1 HPSE GH1 LYN INPP5D PIK3CG PIK3R6 PIK3R5 BTK ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 JAK1 CISH IL12RB2 HSPA9 IL10 SERPINB2 SOCS5 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 AAMP PPIA AHCYL1 KPNA2 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ADAM17 CYFIP2 HMOX2 TEC STK10 FLT3 IRS1 IRS2 EIF4E3 IFIT1 PIK3CB TCIRG1 PPM1B EIF4E2 FLNB FGF2 CAPZB MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS WASF3 ATP6V1G1 ATP6V0B ATP6V0E1 CD180 LY86 ATP6V1G2 PTPN13 EEA1 PDPK1 TASL RBSN FLT3LG IRF5 GAB2 PIK3CA PIK3R3 ATP6V1B2 TLR9 PIK3C3 TRIB3 ATP6V0D1 FAF2 SOS1 SH3RF1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS RHOU ATP6V0A2 THEM4 ATP6V1H MAPK1 ATP6V0A4 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PTPN1 PTPN11 PLD2 UNC93B1 TLR3 CAMK2B CAMK2D SRC CAMK2A CKAP4 ZAP70 LRRC7 CALM1 DOCK2 CAMK2G DOCK1 ANAPC7 MOSPD2 UBE2C PTK2B UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 ARMC8 FBXW11 OPTN SEM1 APP F13A1 LAMP2 HGF ARG1 SERPING1 PGLYRP4 PGLYRP3 STXBP2 DEFB105B PGLYRP2 KIF5C LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B KIFAP3 S100A7A HSPA5 HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 KIF3B SERPINA3 DEFB117 ORM1 DEFB116 SLC11A1 KIF3C SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 KIF4B DEFB112 ORM2 RNASE3 KIF4A DEFB110 TLR1 DEFB130A BPI KIF11 PRTN3 QSOX1 TIMP1 DEFB130B S100A9 CAP1 DEFB4B S100A8 KIF15 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 KIF22 DEFB123 STX4 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A S1PR1 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 KIF26A ACLY ATG5 ATG12 SLC27A2 TCF7L2 CDKN1A TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ACAA1 EIF2S2 EIF2S1 EIF2S3 ATF3 TREM2 TNRC6C MOV10 MYCN STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 HMOX1 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 NUP214 IDH1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 HSPA8 ICAM1 TNFSF13 VAMP2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 APAF1 CASP3 CFD C3 GZMM CFB FURIN VAPA IL1RL1 IL33 CCT2 ROCK1 CUL3 KIF3A VCAM1 RBBP6 VIM AP1G1 ZBP1 AP1S2 TREX1 AP1S1 DDX41 ITGB7 AP1S3 DTX4 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 NLRP4 TRIM32 HLA-A TRIM21 CD8B TRIM56 ELMO1 CD28 HEXB TNFRSF1A GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 NEDD4 MKRN1 FRK CBL PLCG1 CDKN1B FZR1 FNTB SKP2 CDK4 H2AX CSF3R H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CHRNB4 MYLIP NEU1 FBXL21P CTSA REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 F9 PROC F10 PROS1 FURIN PROZ F2 BGLAP GAS6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R5D PPP2R1B MLXIPL PPP2R1A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases SERPINB1 IL18 CASP5 IL1B CASP4 CALM3 CALM2 GSDMD CALM1 CASP3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 OAZ1 OAZ2 ADRM1 OAZ3 AZIN1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants FLT3 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR7 SC5D DHCR24 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA NGFR LINGO1 MAG OMG RTN4 MCF2 RHOA NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism CD38 BST1 NMNAT3 NMNAT2 NMNAT1 NUDT12 NADK NNMT NAPRT NADSYN1 NMRK2 NMRK1 NAXE NADK2 NAXD NAMPT RNLS SLC22A13 NT5E QPRT SLC5A8 PARP10 SLC25A51 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle ARL6IP5 GAD1 GAD2 CHAT SLC18A3 SLC17A7 NAAA STX1A CASK LIN7A LIN7C LIN7B APBA1 SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT GLS2 SLC6A1 CPLX1 RIMS1 UNC13B ALDH5A1 GLS DNAJC5 SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC1A1 SLC1A2 SLC1A3 SYN3 SLC1A6 SYN2 SLC1A7 HSPA8 VAMP2 SLC38A2 MAOA SYN1 SLC6A11 SLC6A12 SLC5A7 TSPOAP1 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle CLTC IQGAP1 PTK2B VANGL1 WWP2 ARHGEF7 PIK3R2 PIK3R1 RHOU ARHGEF6 STAM ARHGAP31 ARHGAP30 SPTAN1 STAM2 GIT1 TXNL1 HGS MYO6 CDC42 DEPDC1B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 SRC ITSN2 PAK1 PAK3 SRGAP2 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair PCNA ERCC6 PCLAF REV1 ISG15 USP43 SPRTN MAD2L2 REV3L ISY1 FIRRM SIRT6 PNKP POLK POLE OGG1 PIAS3 UBE2T RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 UBE2L6 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 HERC2 ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 CDK2 MAPK8 MDC1 FEN1 USP1 DTL UBE2I SUMO1 RBX1 TRIM25 NFRKB CCNH PIAS4 POLR2A POLR2B POLR2C BRCC3 POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J NPLOC4 POLR2K POLR2L MSH3 GTF2H1 GTF2H2 BAP1 GTF2H3 WDR48 GTF2H4 BABAM1 GTF2H5 BABAM2 CDK7 ERCC3 POLI ERCC2 UIMC1 MNAT1 UFD1 ACTB UBB ACTL6A UBC DDB2 RPS27A FAAP100 FAAP24 FAAP20 UBA7 FANCM ERCC8 FANCL FANCA FANCB FANCE FANCG FANCF KPNA2 TP53 DCLRE1C RIF1 MCRS1 POLL NHEJ1 UBE2B POLM TDP2 TDP1 PARG APEX1 ADPRS POLQ KDM4B YY1 RUVBL1 USP7 ABL1 PMS2 MPG MUS81 GPS1 SLX4 EME1 INO80C EME2 INO80B GEN1 INO80E SLX1B VCP INO80D COPS4 SPIDR FANCI COPS2 FANCC CLSPN RNF4 FIGNL1 POLB RNF168 NSD2 CENPX ACTR5 RAD23A ACTR8 RAD23B MSH2 RTEL1 ABRAXAS1 USP10 TP53BP1 UVSSA H2AX TFPT LIG1 H2AB1 MSH6 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 DCLRE1B H2BC21 DCLRE1A POLN FAN1 RNF8 H2AC8 H2AC6 CHEK2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG MBD4 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 MGMT TERF2 H2BC8 H2BC5 SMUG1 NEIL3 XRCC6 H2BC3 AQR XRCC4 H3-4 NEIL2 XRCC5 PARP1 H2BC1 POT1 LIG4 TERF2IP PPP4R2 NEIL1 TIPIN H2AC20 TIMELESS ZNF830 PPP4C POLH RAD52 MLH1 KDM4A FANCD2 SUMO3 SUMO2 PIAS1 PRPF19 PAXIP1 SMARCA5 CENPS PRKDC BAZ1B XAB2 BLM MRE11 RAD18 BRCA1 BRCA2 RAD51AP1 ELL WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 APBB1 RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 EYA4 PPP5C RMI1 TCEA1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 PPIE CCNA2 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR KANK1 ETV6 GOLGA4 BIN2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INS ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 PTPN1 INSR TCIRG1 IDE PTPRF ATP6V1E1 CTSD ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs RASA3 RASA4 RASA2 NRAS CUL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 KBTBD7 PSMA4 PSMA1 NF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 SPRED3 SPRED2 PSMB7 SPRED1 RASAL2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RASA1 ADRM1 SYNGAP1 PSMC5 PSMC6 HRAS SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DAB2IP RASAL1 RASAL3 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 SEC61A2 SEC61A1 CHUK TIRAP TAPBP IKBKB SEC22B MYD88 CALR B2M HLA-A TLR1 VAMP8 S100A9 PSMB10 PSMD8 PSMD6 TLR6 S100A8 PSMD7 TLR2 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMA5 STX4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK CD14 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 FGA PSMB4 TAP2 FGG PSMB5 IKBKG TAP1 TLR4 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A LY96 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 HMGB1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB ACADL HADHA ECHS1 HADH SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 SENP5 NUP107 SENP2 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 SENP1 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG RWDD3 UBA2 DNMT1 SAE1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency OTC BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A2 CYP1A1 ALOX15 LTA4H MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 TAB1 MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PTK6 CDKN1A CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 NUMA1 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events PRKCA PLCB4 GNAQ ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 NBEA PLCB2 CALM1 CAMK2G PRKCD INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling IFNA2 TRIM6 TRIM5 IFNA8 TRIM2 TRIM3 ARIH1 XAF1 IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 NPM1 TRIM45 TRIM35 TRIM38 OAS2 TRIM31 TRIM34 IFITM3 IFITM2 IFNA10 HSPA5 IFIT5 IFI35 IFNA21 IFI30 RAF1 IFIT3 IFNB1 IFIT2 EIF2AK2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 ISG20 YBX1 PRKRA IRF8 IRF6 TARBP2 IRF9 IFNAR1 SAMHD1 PTAFR FLNA HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 KPNB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 FNTA DNAJC3 STAT2 UBE2L6 HERC5 UBE2N ADAR IRF1 IRF2 HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E HSPA1L HSPA2 ATF6 HSPA1B SOCS1 EIF2S2 IFNGR1 EIF2S1 IFNGR2 EIF2S3 EGR1 IKBKB EIF4E UBE2I GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 IRF7 PSMB8 NUP214 PRKCD SFN UBA52 IFIH1 JAK1 ACTB IKBKG UBB UBC TYK2 PTPN2 RPS27A FAAP100 FAAP24 HSPA8 ICAM1 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 KPNA7 FKBP5 KPNA4 KPNA5 GBP1 KPNA3 FURIN FCGR1BP SPHK1 MAP2K6 STAT1 MT2A VCAM1 FANCC B2M SMAD7 IRF3 MAVS HLA-A TRIM21 GBP6 RIGI NUP205 POM121 NUP107 NUP188 FCGR1A AAAS NUP160 POM121C NUP42 NUP85 TPR CENPX NUP62 NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B PML EIF4E2 FLNB MX2 MX1 EIF4G3 EIF4G2 NCK1 SOCS3 EIF4A2 EIF4A1 IRF5 EIF4A3 NCAM1 PPP2R5A STAT3 BST2 MAPK1 DHX9 PIN1 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CD44 PPP2CA PPP2CB IFITM1 CAMK2B PIAS1 CAMK2D SNCA CAMK2A CASP1 EIF2AK3 CAMK2G CENPS IFNG ABCE1 UBE2E1 CDK1 JAK2 ILF3 PTPN6 IRF4 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 TRIM8 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CLPS CEL LIPF PNLIP PNLIPRP3 PNLIPRP1 PNLIPRP2 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors AP2A1 AP2A2 NPM1 AP2M1 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 BTRC NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 KPNB1 CD4 RCC1 RAC1 RANBP1 RANGAP1 ATP6V1H PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 DOCK2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 ARF1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNT1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDK9 RPS27A CUL5 ADRM1 PPIA HCK PSMC5 PSMC6 SEM1 LCK PSMC3 FYN PSMC4 PSMC1 PSMC2 SKP1 PAK2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis XIAP CYCS STAT3 DYNLL1 UACA BAK1 GZMB CDKN2A DYNLL2 MAPK1 BID PPP1R13B MAPK8 BCL2L11 MAPK3 BAD PMAIP1 YWHAB YWHAE AKT1 YWHAQ YWHAG YWHAH YWHAZ SFN GSDMD NMT1 GSDME PPP3CC BAX C1QBP E2F1 TP63 TFDP1 TFDP2 CARD8 BBC3 BCL2 BCL2L1 AKT2 BMF AVEN TP73 APIP TP53 CASP8 CASP9 PPP3R1 TP53BP2 CASP7 APAF1 DIABLO CASP3 AKT3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species NCF1 PRDX2 CYCS NCF2 PRDX1 NCF4 NUDT2 CAT PRDX3 NOX5 ERO1A TXN2 GPX3 GPX6 GPX5 GPX8 SOD2 GPX7 ATP7A CYBB TXNRD2 CYBA PRDX6 ATOX1 SOD3 CCS TXNRD1 SOD1 P4HB GPX1 GSTP1 AQP8 TXN NOX4 GPX2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) MSH6 MLH1 PMS2 MSH2 MSH3 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i ALG2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CAMK2D CALM1 CAMK2G CAMK2A REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements ATF7IP ZNF547 ZNF224 MBD3 GATAD2B GATAD2A ZNF778 RBM7 ZNF454 CHD4 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 MTA1 MTA3 RBBP7 SMARCE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MORC2 H2AC6 H2AC7 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ZNF141 HDAC1 ZNF382 H2AC20 ZNF418 ZNF354A ZNF136 ZNF649 EHMT2 EHMT1 CHD3 SUMO2 UBE2I DPF1 HDAC2 DPF2 DPF3 ZNF28 CBX5 ZNF273 SETDB1 SS18L1 ARID1A ARID1B ZNF816 ZNF610 SS18 SMARCB1 ZNF264 PPHLN1 TRIM28 ZNF30 ZNF257 SMARCC1 SMARCC2 ZNF33A MPHOSPH8 ACTB SPOCD1 ZNF331 ZNF93 ZCCHC8 ACTL6A MTREX TASOR ZNF708 ZNF324 ZNF534 PIWIL4 DNMT3L BCL7A ZNF320 BCL7C SMARCA2 BCL7B SMARCA4 ZNF765 DNMT3A ZNF317 C19orf84 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 MIB2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRR5 DPY30 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 BRD4 PDCD1 RAC1 COPS5 VAV1 MAPKAP1 IRF1 RPN2 TCF7L2 TUSC3 TCF7L1 RPN1 LEF1 MAGT1 TCF7 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MLST8 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 MTOR TEAD3 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 AKT1 PSMD1 HIF1A ICOSLG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 JAK1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PAK2 RICTOR CUL3 VCP STAT1 MAP3K14 CD28 WDR5 RBBP4 RBBP5 RBBP7 CDK4 PPP2R1B H2AX PPP2R1A PIK3CB H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 AKT2 H3-3B H3C8 H2AC8 H2AC6 PAK3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PDPK1 H2BC15 H2BC11 PIK3R3 KMT2A PIK3CA TRIB3 H3C15 PPP2R5E H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D STAT3 PPP2R5C PIK3R2 H2BC1 PIK3R1 NFKB1 PDCD1LG2 B3GNT3 H2AC20 SPOP THEM4 PTPN11 CDC42 PPP2CA PPP2CB SUZ12 GSK3B CD86 CD80 NFKB2 CSK CD274 MAP3K8 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 WWTR1 YES1 SEM1 LCK FYN SKP1 FOS CUL1 AKT3 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy MAP1LC3A CETN1 FUNDC1 PARK7 ATG5 TOMM20 ATG9A ATG12 ULK1 DYNLL1 TOMM7 ARL13B MFN1 TOMM5 DYNLL2 MFN2 TOMM6 TOMM22 HSF1 IFT88 VCP DYNC1I2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 SQSTM1 PLIN3 DYNC1I1 TBK1 PRKAB2 DYNC1H1 PRKAB1 UBE2D2 UBE2D3 EPAS1 PINK1 USP30 VDAC3 VDAC2 VDAC1 UBE2L3 MAP1LC3B CFTR HSP90AA1 UBA52 HDAC6 PLIN2 TOMM70 UBB UBC DYNC1LI1 PEX5 RPS27A NBR1 DYNC1LI2 UBE2V1 OPTN PRKN HSPA8 CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 UBE2N PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly APOC4 A2M APOC3 APOC2 APOC1 P4HB APOA2 ZDHHC8 APOA1 APOA4 APOB PRKACG PRKACA PRKACB APOE ABCA1 SAR1B MTTP CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling CD86 CD80 PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 RICTOR MAP3K8 PIK3CB MLST8 PIK3CD AKT2 MAP3K14 MTOR LCK CD28 FYN PRR5 PDPK1 AKT1 PIK3R3 PIK3CA MAPKAP1 AKT3 TRIB3 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B1 SLCO1B3 ABCC1 ABCG2 ALB GSTA1 UGT1A4 HMOX1 BLVRB HMOX2 ABCC2 BLVRA UGT1A1 FABP1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B2 SRD5A3 CGA HSD3B1 CYP17A1 HSD11B1 HSD11B2 STARD3NL CYP19A1 POMC CYP11A1 STS SRD5A2 SRD5A1 HSD17B1 CYP11B2 SERPINA6 HSD17B2 CYP11B1 TSPO LHB HSD17B3 HSD17B12 CYP21A2 FDXR STARD3 STARD4 STAR STARD6 AKR1B15 HSD17B14 FDX1 HSD17B11 FDX2 AKR1B1 TSPOAP1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation RPS6KA1 ATF1 MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 RPA1 ERCC8 DDB1 RPA2 XPA POLE4 CUL4A RPA3 PPIE ERCC4 ERCC1 POLE2 POLE3 ERCC5 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGAP32 ROCK1 ROCK2 ARHGAP44 PREX2 ARHGAP40 ARHGDIA HMOX2 STARD8 ARHGAP8 ARHGAP45 AAAS ARHGEF25 CIT IQGAP1 PKN3 PLD1 IQGAP3 STX5 ARHGAP22 ARHGAP20 SRGAP1 STARD13 JUP VMA22 ARHGAP29 ARHGAP24 PKN2 PKN1 ARHGAP31 FAM13A STK10 ARHGAP30 SLK C1QBP ARHGAP9 ARHGAP11B TEX2 ARHGAP4 DDRGK1 TAGAP PLEKHG3 PLEKHG4 BCAP31 ARAP1 GMIP ARHGAP11A TJP2 ARHGAP10 DAAM1 TRIO RASGRF2 PLEKHG6 ARHGEF10L AKAP13 PREX1 STOM MCF2L ARHGEF40 FARP1 VAV3 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 DEF6 VAPB KTN1 ARHGEF15 PLEKHG5 DLC1 TMEM87A DIAPH1 ARHGEF17 FLOT1 ARHGEF19 SCFD1 DIAPH3 FLOT2 ARHGEF18 VAV1 VAV2 ANLN TIAM1 FAF2 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF KALRN RHOA EMC3 CAVIN1 MYO9A ABR RTKN ECT2 ARHGEF28 ARHGAP19 ARHGAP18 MCF2 NET1 RHPN1 RHPN2 ACBD5 MACO1 ARHGAP28 ARHGAP23 FMNL3 ABCD3 SOWAHC DOCK2 TFRC SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP42 OPHN1 STBD1 ARHGDIB LBR TMPO ARAP2 ARAP3 BCR DEPDC1B VAMP3 ARHGAP21 LMAN1 PGRMC2 RACGAP1 YKT6 CAV1 MCAM ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SLC39A2 SLC39A1 SLC39A3 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis IRF1 XIAP IRF2 CYCS CHMP3 CHMP6 TNFRSF10B CHMP7 TNFRSF10A BAK1 GZMB ITCH FAS FASLG RIPK1 OGT CASP1 STUB1 UBE2L3 TRAF2 TNFSF10 HSP90AA1 CDC37 UBA52 BIRC2 FADD ELANE BIRC3 GSDMD GSDME BAX TP63 RIPK3 IL18 IL1A IL1B PELI1 UBB UBC RPS27A CHMP4C CHMP4B CHMP4A PRKN SDCBP MLKL CHMP2B CHMP2A TRADD HMGB1 TP53 CASP8 CASP5 CASP4 FLOT1 FLOT2 CASP3 PDCD6IP ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 SEC22B SERPINA1 SEC23A COPE ARF4 F5 TMED3 F8 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 NSF CTSC CAPZA3 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A TMED2 SPTB DYNC1I1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ANK1 AREG DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 TGFA YKT6 ARFGAP1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RXRA CREBBP CHD9 PPARGC1A NCOA2 NCOR1 NCOA6 TBL1XR1 EP300 SMARCD3 MED1 TGS1 HDAC3 RORC RORA NR1D1 NRIP1 CARM1 TBL1X NCOA1 CPT1A SREBF1 HELZ2 PPARA REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 UBC TICAM2 TICAM1 RPS27A TBK1 TRAF3 OPTN LY96 UBA52 CD14 IKBKE TANK UBB TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation RELA MAP3K7 RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CARD11 IGKV2D-28 MALT1 IGKV4-1 IGHV7-81 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 TAB1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV TRAF6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 PRKCQ UBE2N NFKB1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 V1-11 V1-16 V1-13 CHUK V2-8 IKBKB V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 LYN PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 RASGRP4 CUL1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors LDLRAP1 CUBN AMN APOA2 ACO1 APOA1 ABCD4 APOA4 SLC2A1 PRKG2 PRSS3 LPL LMBRD1 LDLR GPIHBP1 APOC3 LRP8 FLAD1 RFK SLC52A2 APOB SLC52A3 ACP5 SLC52A1 NOS3 ENPP1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR PDZD11 GCHFR GCH1 SPR PTS NNMT PNPO AOX1 NAMPT SLC5A6 ACACA STARD7 FASN COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A SDC4 SDC2 SDC3 SLC46A1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 AKT1 IDH1 COQ2 GSTO1 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC PCCA HLCS MCCC1 PCCB ACACB NUDT12 NADK CYB5R3 THTPA TCN1 NMRK2 NMRK1 RBP4 NAXE RBP1 LRAT NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MOCOS MMAB SLC22A13 QPRT SHMT2 MTRR SLC25A51 SLC25A19 CD38 GPHN HSP90AA1 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 NMNAT1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 TCN2 CD320 AKR1C1 TTR CBLIF AKR1C4 MMACHC MMADHC PLB1 BST1 VNN1 HSPG2 APOE GSTO2 AGRN APOC2 ABCC1 MTR SLC2A3 CALM1 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 BCO1 VKORC1 AKR1B10 NAPRT CLPS RBP2 LRP10 LRP12 PNLIP PDXK NADK2 RDH11 AKR1C3 SLC5A8 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation YARS1 EEF1E1 KARS1 EPRS1 NARS1 IARS1 PPA1 TARS1 AARS1 CARS1 HARS1 FARSA FARSB RARS1 LARS1 AIMP1 AIMP2 WARS1 QARS1 MARS1 GARS1 DARS1 SARS1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP9 DUSP4 TYK2 DUSP6 DUSP7 DUSP10 IL6R CDK1 IL6 PEA15 MAPK1 DUSP5 DUSP2 DUSP1 JAK2 DUSP16 JAK1 MAP2K1 MAP2K2 MAPK3 PTPN11 DUSP8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 SLC19A3 SLC19A2 THTPA TPK1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA1 GRIA2 GRIA3 GRIA4 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C CDK2 MDC1 CLSPN SUMO2 UBE2I RNF4 RNF168 NSD2 PIAS4 BRCC3 UBA52 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN UBB TOPBP1 SIRT6 ATRIP BARD1 RFC5 UBC RMI2 H2BC26 RFC3 RFC4 RPS27A H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB DCP1A ZFP36L1 EXOSC7 EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway CHST8 CHST10 FUT3 FUT8 MAN2A2 CGA MAN2A1 LHB MGAT2 FUCA1 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion F9 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development ROBO2 WFDC2 MECOM GFRA1 OSR1 GATA3 HOXA6 BMP4 PAX8 PLAC8 FOXC2 ITGA8 CTNNB1 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 GREM1 SALL1 SIX2 EYA1 FGF2 HOXB4 IRX1 ID4 LFNG IRX2 JAG1 SLIT2 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 POU3F3 WNT4 WNT11 ITGB1 EMX2 PCDH19 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 CLTC CLTB FZD5 WNT5A AP2S1 ROR1 CLTA ROR2 AP2A1 AP2A2 AP2B1 AP2M1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils PXDN LOXL1 PCOLCE LOXL2 TLL2 TLL1 LOX LOXL3 LOXL4 BMP1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAH SFN YWHAZ YWHAE PDPK1 AKT1 AKT2 YWHAQ CAV1 YWHAG YWHAB AKT3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility ITGA3 CRK LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 RAP1B RAP1A ITGA2 MET DOCK7 RAPGEF1 TNS4 TNS3 SRC RAC1 GAB1 HGF PTK2 CRKL ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 HBB APOA1 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 BACH1 CLOCK NPAS2 TLR4 HELZ2 RAI1 CREBBP CHD9 MAFK NCOR1 SLC46A1 MEF2C TBL1XR1 NFE2L2 EP300 LY96 CLEC1B MED1 TGS1 MEF2D PGRMC2 APOB HBA2 RORA HMOX1 SIRT1 XPO1 PPARA CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway CDC42 LCK CD28 RAC1 FYN CD86 CD80 PAK2 VAV1 PAK1 PAK3 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 ARPC1A LDLRAP1 AP2M1 BIN1 STAM2 ARPC4 STON1 GPS1 ARPC5 STON2 ARPC2 ARPC3 SNX18 COPS4 ACTR3 ACTR2 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 CTTN SGIP1 AP2S1 AGTR1 DNAJC6 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 HIP1R AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 FNBP1L SNX9 APOB SNAP91 M6PR SYT2 GAK ARRB1 FNBP1 ARRB2 SCARB2 AMPH PACSIN2 PACSIN3 PACSIN1 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 RAB5B RAB5C TGOLN2 CHRM2 ARF6 HGS RAB5A WASL CD4 GAPVD1 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 TRIP10 DNM1 SLC18A3 DNM2 DAB2 EPS15L1 EPN1 PIK3C2A SYT9 GRK3 PICALM VAMP8 DNM3 IL7R TFRC PIP5K1C CFTR SYT1 IGF2R UBA52 STAM HIP1 OCRL UBB SYNJ2 SYNJ1 UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 HSPA8 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG ARFGAP1 BTC EPGN HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON SPOP ITCH CUL3 KIF7 IHH SMO GPR161 KIF3A PTCH1 GLI3 GLI2 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 ARRB1 PSMD2 RBX1 ARRB2 PSMD3 PSMD1 CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 NUMB PSMD13 PSMA7 PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 PSMC2 ULK3 GRK2 DZIP1 SPOPL REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway FYN SH3KBP1 VLDLR RELN DAB1 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LDLR APOE LIPC LDLRAP1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation RXRA MED19 MED18 SREBF2 MED11 RELA WNT1 NFKB1 MED9 MED29 KLF5 MED28 MED22 TGFB1 MED21 HDAC3 CDK19 CEBPB TBL1X MED13L ANGPTL4 PCK1 NCOA1 LPL EGR2 FABP4 CDK8 NCOR2 NCOR1 TBL1XR1 PLIN1 THRAP3 LEP FAM120B CD36 PPARGC1A NCOA2 NCOA6 NCOA3 CCNC SMARCD3 CCND3 CARM1 ADIPOQ CDK4 MED16 HELZ2 MED15 KLF4 MED17 CREBBP CHD9 MED12 MED14 MED13 TNF MED10 EP300 EBF1 WNT10B NR2F2 ADIRF SLC2A4 MED1 MED30 ZNF638 TGS1 CEBPD MED31 ZNF467 MED8 MED4 MED27 MED6 MED26 MED7 MED23 MED25 CEBPA MED24 MED20 PPARG PPARA DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CREBBP BMAL1 KMT2A CLOCK TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 YAP1 SERPINB13 ABL1 ITCH GPAM ARID2 ESR1 AUTS2 IL2 IL3 TCF3 LDB1 SIN3B DPY30 WDR5 CR1 ELF1 ELF2 SMARCD1 SMARCD2 FOXP3 SMARCD3 CCND3 CCND2 RBBP5 CDK6 BLK SMARCE1 KMT2D H2AX SPI1 PML H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 MYB EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ ZFPM1 H2BC15 PRKCQ TAL1 H2BC11 KMT2A CBFB ITGA2B SOCS4 GATA2 H3C15 OCLN H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 GP1BA SETD1B SETD1A NFATC2 CCND1 SIN3A TJP1 LMO1 YAF2 LMO2 PTPN11 LIFR KCTD6 TNFRSF18 ASH2L TNRC6C MOV10 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 RSPO3 SRC TNRC6A TNRC6B CLDN5 NR4A3 RNF2 PSMD8 PSMD6 CBX8 PSMD7 PHC2 TCF12 MYL9 PHC1 PAX5 PSMD2 CBX4 PSMD3 CBX2 PSMD1 PHC3 ARID1A IL2RA ARID1B GATA1 AXIN1 IFNG CCNH PSMA5 PSMA6 PSMA3 GATA3 PSMA4 THBS1 PSMA1 SMARCB1 PSMA2 LGALS3 UBA52 PSMD12 PSMD11 PCGF5 PSMD14 PSMD13 PSMA7 HIPK2 SMARCC1 SMARCC2 PSMB6 RYBP CDK7 PSMB7 PSMB4 MNAT1 PSMB5 PF4 UBB PSMB2 CSF2 ACTL6A PSMB3 CREBBP UBC PSMB1 RPS27A KAT2B CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 SMARCA2 PSMC4 SMARCA4 ACTL6B PSMC1 CSNK2B PSMC2 TP73 CTSV CTSL CTSK PBRM1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KPNA6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins DEFA5 DEFA3 ART1 DEFA1B PRSS3 PRSS2 CD4 DEFA6 DEFA4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNA6 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor RASGRF2 CAMK2B NRAS CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism MTR MTRR MMAA MMUT MMAB MMACHC MMADHC DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF1 ALYREF DDX39B CPSF3 CPSF2 SRRM1 DHX38 NXF2B SYMPK NXT1 UPF3B MAGOHB EIF4E RNPS1 NUP205 WDR33 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG GALE DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide VCP TCF25 ANKZF1 KLHDC10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism ACADSB ACAD8 MCCC2 ECHS1 ACAT1 MCCC1 BCAT1 SLC25A44 BCAT2 ALDH6A1 HIBADH PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH HSD17B10 DLD GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation OGDH KGD4 GCSH GLDC AMT DLST DLD CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly CEP41 CEP43 IFT172 KIFAP3 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 RPGRIP1L CCT3 PRKACA WDR35 IFT88 SMO TCP1 KIF3A TTC21B WDR19 IFT122 KIF3B MKS1 KIF3C ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CEP97 YWHAE CNGA4 TUBB4B KIF17 BBS5 TUBB4A BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 YWHAG BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B HSP90AA1 ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 HDAC6 RHO RAB11A ATAT1 TTC8 CNGB1 PPP2R1A CPAP DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 PDE6D MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 TNPO1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DDX21 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway UBC TAB3 RPS27A ALPK1 TAB2 MAP3K7 TRAF6 UBA52 UBB TIFA TAB1 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 NGF PLCG1 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events HRAS MAPKAPK3 RALGDS RALB MAPK12 MAPK13 MAPKAPK2 NRAS MAPK14 MAPK11 RALA SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL3 ITGA1 RHOC HSP90AB1 RHOA RHOB ROCK1 ROCK2 PLXNC1 MET SEMA6A PLXNA4 SEMA6D SEMA7A CDK5R1 PLXNB3 TREM2 SEMA3E SEMA4A CDK5 SEMA5A RND1 MYL9 GSK3B TYROBP SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 FARP2 HSP90AA1 ERBB2 CD72 ARHGAP35 PLXND1 CFL1 PTPRC PLXNA1 PLXNB1 TLN1 SEMA4D PAK1 PAK3 LIMK2 RAC1 LIMK1 MYL12B FYN MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 MYH10 PAK2 NRP1 CRMP1 ITGB1 DPYSL4 DPYSL5 DPYSL2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism CYB5B VAPA GAL3ST1 CERK GBA3 GBA2 MFSD2B SMPD3 SMPD2 SPHK1 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLPP3 SUMF1 PLPP2 B3GNT5 PLPP1 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 SGPL1 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG ACER2 HEXB ARSD ACER1 HEXA B3GALNT1 GLB1L3 B3GALT4 M6PR ACER3 GLB1L2 GALC GLA GLB1L GLB1 SPTLC1 ARSB SPTLC2 SPTLC3 ORMDL2 ORMDL3 SPTSSB SPTSSA ORMDL1 VAPB PRKD3 PRKD2 PRKD1 SPNS2 ABCG2 ALDH3B2 ALDH3B1 FA2H DEGS1 DEGS2 SPHK2 SAMD8 SGMS1 ABCC1 SGMS2 OSBP SGPP2 SGPP1 CSNK1G2 KDSR ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CERS3 ST3GAL2 CERS4 ST3GAL3 CERS5 CTSA CERS6 CERS1 CERS2 PPM1L SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 GNAQ GNA15 PLCB3 PLCB1 FFAR1 PLCB2 GNA11 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A3 SLC26A9 SLC26A6 SLC26A11 SLC26A1 SLC26A4 SLC26A7 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly APOC4 APOB APOC1 MTTP P4HB M PHASE%REACTOME%R-HSA-68886.5 M Phase PRKACA YWHAE EML4 CDCA5 NCAPG YWHAG ARPP19 NCAPH ENSA SIRT2 USO1 NCAPD2 TUBB8 RAB2A IST1 VRK1 LEMD2 TUBB8B NUMA1 FIRRM ESPL1 RAB1A RAB1B GOLGA2 FBXO5 BLZF1 KPNB1 SPAST CC2D1B CNEP1R1 PTTG1 MASTL GORASP2 GORASP1 PPP2R2D CHMP4C CHMP4B CHMP4A PRKAR2B PRKCB CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 TUBB PSMB6 CEP131 PSMB7 HAUS4 HAUS3 CSNK1D PSMB4 HAUS6 PSMB5 HAUS5 CSNK1E TUBG2 LEMD3 UBB TUBG1 PSMB2 PSMB3 TUBB6 HAUS2 TUBB3 HAUS1 MZT2B TUBB1 UBC MZT2A PSMB1 NME7 AKAP9 RPS27A CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 ADRM1 CSNK2A1 DCTN3 HAUS8 PSMC5 HAUS7 CSNK2A2 CEP70 PSMC6 CEP72 PSMC3 TUBA4B CEP192 PSMC4 PCNT PSMC1 TUBA4A CSNK2B CEP76 PSMC2 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS KMT5A NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 HSP90AA1 NDC1 RANBP2 SEC13 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 CPAP KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 RCC1 H2BC21 ZW10 MAD1L1 H3-3B CDCA8 H3C8 H2AC8 PMF1 SKA1 H2AC6 SKA2 KIF23 H2AC7 DSN1 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 RCC2 STAG1 H2BC15 NIPBL NDC80 ZWINT STAG2 H2BC11 RAD21 KIF20A KIF18A RPS27 AHCTF1 H3C15 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 H2AC20 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 LPIN1 CENPT LPIN2 DYNC1H1 CENPU LPIN3 NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 TIAM1 RAC1 NTRK2 BDNF CDK5 CDK5R1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 PSEN1 UBB NOTCH2NLA UBC NOTCH2NLC NOTCH2NLB RPS27A MDK JAG2 JAG1 DLL1 NOTCH2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA AREG EGF MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CLIP1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G2D PLA2G2E MBOAT1 PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 ABHD4 PLAAT1 PLAAT3 PLA2G2A PLAAT2 PLAAT5 PLAAT4 PLA2G4A PNPLA8 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 LPCAT3 PLBD1 PLA2G2F REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A11 SLC6A13 SLC6A12 SLC6A1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 LIPC LDLRAP1 UBA52 AP2M1 CUBN AMN APOA1 LSR NPC1 SOAT1 SOAT2 APOE NPC2 CES3 UBB MYLIP NR1H2 APOC4 UBC AP2S1 NR1H3 LDLR RPS27A APOBR AP2B1 APOC1 NCEH1 APOB BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import TOMM20 GFER OTC TOMM7 TOMM5 TOMM6 SAMM50 TOMM22 MTX1 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX19 COX17 ATP5MC1 TIMM50 PITRM1 GRPEL1 GRPEL2 LDHD CYC1 DNAJC19 COA4 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 HSPD1 ACO2 HSCB TIMM17A TIMM17B COA6 SLC25A4 SLC25A6 TIMM23 TIMM22 HSPA9 TIMM21 TOMM70 SLC25A12 PMPCB FXN PMPCA SLC25A13 NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B VPS28 CHMP4A TSG101 VPS37C VPS37D VPS37A VPS37B GABARAP CHMP2B CHMP2A MVB12B EEF1A1 MVB12A UBAP1 UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A RNASE1 CHMP3 ATG12 GFAP ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B HSP90AB1 DYNLL2 HBB TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B LAMP2 ATM MTERF3 WIPI1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates NUDT13 AK1 RRM2 AK2 AK4 NME1 AK5 AK6 AK7 AK8 DCTPP1 AK9 GLRX NME2 NME3 NME4 DCTD TXNRD1 CMPK1 TYMS CTPS2 CTPS1 RRM1 RRM2B DTYMK TXN GUK1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate SRD5A3 MVD DOLK DOLPP1 DHDDS NUS1 DHRSX DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k ALG1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling DUSP6 DUSP7 KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G DUSP8 DUSP9 IQGAP1 MRAS FAM114A2 QKI NF1 KIAA1549 DUSP10 ESRP1 TRIM24 FXR1 FN1 PHB1 AGTRAP MAP3K11 ARAF AP3B1 PEBP1 SHOC2 CSK AGGF1 JAK2 TENT4A DUSP16 MARK3 SPRED3 FGB SPRED2 BRAP SPRED1 FGA VWF KSR1 KRAS PPP1CB FGG PPP1CC BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes ACSS3 CXXC1 AGPAT2 ABL1 KANSL1 KANSL2 KANSL3 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 TADA3 OGT DPY30 WDR5 PSIP1 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA KMT2A H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 SETD1B SETD1A HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 PHF20 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 KAT8 HCFC2 WDR82 PAXIP1 PEX11A AJUBA KAT14 ZZZ3 HCFC1 TADA2A SGF29 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC PHF20L1 NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 BOD1L1 CREBBP MED17 MBIP MED12 TASP1 MED14 DR1 MED13 BOD1 KAT2B KAT2A YEATS2 MED10 MEN1 AKAP8L PAGR1 MED27 KDM6A SIRT1 MED23 MCRS1 MED24 MED20 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED1 CITED2 CITED4 CGA YY1 HSPD1 ERBB2 VEGFA CDKN1A EGFR DEK NPM1 APOE ATAD2 CREBBP YEATS4 NOP2 TFAP2A TFAP2B ESR1 EP300 WWOX MYC TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 KDM5B CGB8 TGFA KIT MYBL2 PITX2 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly APOA1 APOA4 APOB APOE APOC2 APOC3 SAR1B MTTP P4HB APOA2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant F9 F10 F8 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway BAIAP2 ABI2 PIK3R2 PIK3R1 ABI1 NRAS RHOA THEM4 RICTOR ROCK1 ROCK2 PRKACG PRKACA CTNNB1 PRKACB SPHK1 ELMO2 CDC42 MLST8 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 MTOR HSPB1 SHC2 NOS3 PRR5 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA NCF2 KDR CRK NCF4 PTK2B PXN BRK1 HSP90AA1 MAPKAPK2 JUP CTNND1 PLCG1 CTNNA1 SHB CYBB CYBA SH2D2A PIK3CB MAPKAPK3 CDH5 AXL NCK2 NCK1 RASA1 AKT2 MAPK14 PRKCZ MAPK11 PAK1 PAK3 RAC1 HRAS PRKCB WASF3 BCAR1 AHCYL1 FYN VAV3 PDPK1 NCKAP1L WASF1 PAK2 WASF2 PTK2 PIK3CA ITGB3 VAV1 VAV2 CAV1 AKT3 ITGAV TRIB3 MAPKAP1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair PCNA KDM4B ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 CHEK2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 PARP1 H2BC1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MAPK8 MDC1 KDM4A FEN1 SUMO2 UBE2I SUMO1 PAXIP1 SMARCA5 PIAS4 BRCC3 UBA52 PRKDC BAZ1B BAP1 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 APBB1 UBC RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 RPS27A EYA4 PPP5C RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 KPNA2 RAD17 DCLRE1C TP53 CCNA2 RAD1 RIF1 ATM CCNA1 DNA2 POLL NHEJ1 RAD9B RHNO1 POLM TDP2 ATR TDP1 RAD9A POLQ METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors COQ9 DHFR COQ7 COQ6 COQ5 COQ2 COQ4 HSP90AA1 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ACO1 GCHFR GCH1 SPR PTS PRKG2 NOS3 STARD7 AKT1 CALM1 IDH1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells EOMES SOX17 CXCR4 BMP4 PDPN PRDM1 TET2 TFAP2C POU5F1 NANOG NANOS3 CBFA2T2 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism CPOX SLCO1B1 SLCO1B3 ABCG2 UROD GSTA1 UROS ALAS2 BLVRB ABCC2 BLVRA COX15 ALAD FABP1 FECH COX10 PPOX ALAS1 HMBS ABCC1 ALB UGT1A4 HMOX1 HMOX2 UGT1A1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication HDLBP KPNA7 NACA FASN KPNA4 KPNA5 KPNA3 BTF3 RPN2 BAG2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 VCP SPCS2 DNAJA2 PRKG2 SPCS1 OST4 SEC11A RTN3 SEC11C HSPA1B DDOST VIM TMEM258 DAD1 OSTC CANX CALR ACOT2 YBX1 STT3A EIF4E STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 MAP1LC3B KPNA1 XRN1 IPO7 DNAJB11 PABPC1 P4HA1 UBA52 P4HA2 P4HA3 NPLOC4 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UFD1 RRBP1 UBB EIF4E3 UBC DNAJC3 RPS27A EIF4G3 EIF4G2 SUN2 HSPA8 EIF4A2 EIF4A1 HSPA1A KPNA2 EIF4G1 EIF4A3 ATL2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism MAPDA NT5C2 ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling CAPZA1 PRKCSH AGER LGALS3 S100A12 MAPK1 APP S100B SAA1 HMGB1 CAPZA2 MAPK3 DDOST ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria DCXR NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PCNA YY1 RUVBL1 USP7 ERCC6 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ISY1 ACTR5 RAD23A ACTR8 RAD23B UVSSA TFPT LIG1 POLD3 POLD4 POLK POLD1 POLE POLD2 PIAS3 RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 AQR PARP1 ZNF830 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 PRPF19 RBX1 NFRKB CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 CDK7 ELL ERCC3 ERCC2 MNAT1 ACTB UBB ACTL6A UBC RFC5 RFC3 RFC4 DDB2 RPS27A TCEA1 RFC2 RPA1 ERCC8 RPA2 RPA3 PPIE MCRS1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription IRF1 JUN YAP1 H2BC9 H2AZ2 H4C9 H2BC8 RELA H2BC5 H2BC3 STAT3 TCF7L2 H2BC1 NFKB1 TCF7L1 H2AC20 LEF1 TCF7 CTNNB1 STAT1 ATF3 JUND ASH2L MYCN FOSB MYC TEAD1 TEAD2 TEAD3 TEAD4 SUZ12 DPY30 EPAS1 WDR5 HIF1A EED RBBP4 NFKB2 EZH2 RBBP5 RBBP7 H2AX CREBBP H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 NFE2L2 EP300 H3-3B H3C8 H2AC8 WWTR1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS H2BC11 KMT2A H3C15 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism AADAT SLC3A2 ACMSD AFMID SLC36A4 HAAO KYAT1 TDO2 IDO2 IDO1 SLC7A5 KYAT3 KMO KYNU PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease TALDO1 RPIA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW DPM2 PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions ITGB4 DDR2 DRP2 ITGB5 DMD ITGA6 TNC PDGFB TGFB1 ACTN1 ITGA2 HSPG2 UTRN SNTG2 SDC4 SDC2 SDC3 TRAPPC4 SGCE SGCD AGRN SGCA NTN4 SGCB SGCG SNTA1 SGCZ NRXN1 SNTB1 CASK SNTB2 SDC1 PRKCA LAMA5 LAMA2 THBS1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN DAG1 FGF2 PDGFA TTR DTNA DTNB SSPN DDR1 ITGB3 ITGB1 ITGAV DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes KLF4 FOXG1 SMAD2 SMAD4 SMAD3 PCBP4 FOXO1 CDKN1A CDKN1B CCNG2 MSTN FOXO3 FOXO4 GADD45A CAV1 RBL2 BTG1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ZNF420 CREBBP BBC3 BNIP3L PRELID3A PMAIP1 PRELID1 STEAP3 AIFM2 TP53AIP1 TP53INP1 BAX BID TP63 TP73 PPP1R13B TP53 ATM TRIAP1 TP53BP2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome DDX5 ZCRB1 VHL RB1 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism PLPP2 ACER2 PLPP1 ACER1 ALDH3B2 SGPP2 ACER3 SGPP1 ALDH3B1 SGPL1 PLPP3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation SLC26A2 SRD5A3 GALT B3GALT6 B4GALT7 NCAN HEXB HEXA BGN DCN BCAN VCAN GLB1 CSPG5 CSPG4 GALM ADAMTS13 POMT2 POMT1 POMGNT1 B4GAT1 DAG1 PGM1 LARGE1 GALK1 CHSY1 GALE PRELP CHST6 OMD KERA NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 MUC13 CHST14 HSPG2 MGAT2 PAPSS2 MOGS SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B4GALT1 MAN1B1 GPC1 GPC3 GPC2 GALNT12 GPC5 DPAGT1 SEMA5A GPC4 SPON2 SEMA5B GPC6 SPON1 THSD7B MPI ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 EXT1 ADAMTS3 SDC1 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 THSD7A ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 DPM1 ADAMTS12 DPM2 THSD1 DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 NEU1 SSPOP MUC5B MUC20 MUC21 LFNG ST3GAL3 MPDU1 CTSA NUS1 PMM2 GFPT1 DOLK BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DBT DLD ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense UBC GBP1 RPS27A UBA52 GBP2 GBP6 UBE2D2 GBP4 CASP4 CALM3 CALM2 CALM1 UBB DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants FLT3 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels HCN4 HCN3 HCN2 HCN1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 NEURL1B GZMB UBA52 HES5 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 UBB RBPJ NOTCH2NLA UBC NOTCH2NLC MAML2 NOTCH2NLB MAML1 FCER2 RPS27A MDK EP300 JAG2 JAG1 DLL1 MAML3 NOTCH2 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 HDAC2 KAT8 KDM5B SUZ12 KAT14 SETDB1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SMARCB1 AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 SMARCA2 SMARCA4 KDM6A DNMT3A PBRM1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM SLC34A2 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation HBA2 HBB RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway UBA3 UBE2M CHUK TNFRSF18 RELB MAP3K14 PSMD8 PSMD6 TNFRSF6B PSMD7 EDA TNFRSF13B PSMD2 TNFRSF11B EDA2R PSMD3 TNFSF13B TNFRSF1A PSMD1 TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 PSMA5 TNFSF15 PSMA6 CD70 TRAF2 PSMA3 TNFRSF9 EDAR PSMA4 PSMA1 TNFSF6 TNFSF4 PSMA2 LTA TRAF3 CD27 TNFRSF12A TNFSF9 TNFRSF25 UBA52 BIRC2 TNFSF12 TNFRSF13C TNFSF8 BIRC3 PSMD12 TNFRSF11A PSMD11 CD40LG LTBR LTB PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 TNFRSF1B RPS27A TNF FBXW11 TNFSF13 TNFRSF14 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 APOD SLC27A4 LCN12 LCN1 SLC27A6 LCN9 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 OMA1 PHB2 YME1L1 EIF2AK1 DELE1 EIF2S2 EIF2S1 EIF2S3 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 FURIN IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 SPCS3 ISG15 SPCS2 MED13L SPCS1 CD209 SEC11A SEC11C CDK8 IRF3 IFNAR1 MAVS RIGI TLR2 HSP90AA1 EGFR CD14 RAB5B RAB5C BECN1 TLR7 RAB5A KPNB1 PPP1CC TLR4 BCAP31 STAT2 EP300 LY96 MED1 MED30 MED31 MED8 MED4 MED6 MED7 H2BC15 UBE2L6 HERC5 HSP90AB1 HSPG2 SDC4 SDC2 SDC3 AGRN TLR3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TLR6 ELOB XPO1 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 PPP1CA IFIH1 JAK1 PPP1CB UBB MED16 MED15 CREBBP MED17 UBC MED12 TYK2 MED14 MED13 RPS27A NCL MED10 HSPA8 CUL5 CSNK2A1 CSNK2A2 CSNK2B MED27 MED26 MED23 IGF1R MED25 IFNA5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 CUBN CBLIF AMN LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs FLT3 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBIN HSP90AA1 ERBB2 CDC37 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 GNB5 GNGT1 CCT2 GNGT2 CCT3 TCP1 CCT6B CCT7 GNA14 GNG3 RGS9 GNA15 RGS6 RGS7 GNG2 GNG5 GNG4 GNG7 CSNK2A1 GNA11 GNG8 CCT8 CSNK2A2 CCT5 CCT4 CSNK2B RGS11 GNG10 GNG12 GNG11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER PCNA UBA52 UBB LIG1 UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLE2 POLE3 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 YAP1 HBEGF STAT5A GFAP SPARC STMN1 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 APOE ADAP1 CSN2 NCOR1 CXCL12 MXD4 ESR1 WWOX ADAM17 SRC NRG1 S100B TAB2 EREG NRG3 PGR NRG4 NRG2 BTC ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System YAP1 SEL1L RELA ERLIN1 ERLIN2 ITCH KLC1 RNF185 KLC4 KLC3 KLC2 IFI30 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 KIF5B KIF5A HLA-DOA HLA-DOB LAG3 CTSO CTSF CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG EED RNF111 UBE2V2 RAC1 PRKCB PRKCQ COPS5 UBE2N VAV1 MAPKAP1 NEDD4L CD81 V2-11 DCTN6 V3-4 DCTN5 V3-3 V2-17 DCTN1 DCTN4 V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 CAPZA3 CAPZA2 ACTR10 SOCS1 CD19 IKBKB V2-8 V1-20 MYD88 ASH2L V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 TEAD2 UBE2D2 TEAD3 UBE2D3 TEAD4 ELOB V4-6 ELOC V4-2 RBX1 V4-1 EPAS1 CUL2 HIF1A VHL ICOSLG WWP1 FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B CTSB FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 XDH SIGLEC9 SIGLEC5 WDR5 SEC13 RNF34 RBBP4 RBBP5 PTPRC RBBP7 ITGB2 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 PTPRJ KIF2A ACTR1B CTSH CD33 EVL CTSC KIF2C KIF2B CHUK DYNC1I2 CDC42 PPP2CA KCTD6 PPP2CB LILRA3 DYNC1I1 DYNC1H1 LAIR1 SMURF1 LILRB2 CENPE LILRB3 CD300A OSCAR TYROBP SELL NFKB2 CSK FGB FGA CD274 FGG SYK LCK FYN SKP1 CUL1 CLTC CLTA AP2A1 AP2A2 AP2M1 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 VASP IGHM SH3KBP1 IGHV4-34 IGHV1-2 ITK IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 IGLC3 TRAV29DV5 TRBV7-9 BLNK GRAP2 TRBC1 IGLC1 IGLC2 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 IGKV3D-20 IGHD TRAV19 HLA-DRB4 FYB1 IGKV2-30 ENAH IGLV3-19 HLA-DPB1 IGHV2-70 TRAV8-4 IGHV2-5 HLA-DRA IGLV3-1 LCP2 IGHV3-48 HLA-DRB3 IGLV3-25 HLA-DRB1 IGLV3-27 IGKC HLA-DQB2 IGKV1-39 LAT IGLV3-21 CD101 IGKV1-33 HLA-DQB1 FCGR3A BRD4 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDCD1 PPP3CA PPP3CB LRR1 CCNF UBE2L6 CBLB HERC5 PPP3R1 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 FBXO9 NFATC1 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 DNM2 RNF217 PRKAA1 ATG7 PRKAA2 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 JUND CD207 CALR FBXL4 MLST8 DZIP3 RNF220 FOSB DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 LRRC41 MTOR VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 NCF1 KBTBD6 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 ACTR1A RNF19B UBE3A UBE3B FBXO21 NEK2 UBE2Z FBXO22 NFATC3 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 TRAIP RAB7A RNF41 KLHL42 UBE2V1 DCTN2 CUL7 CUL5 UBA7 UBA6 DCTN3 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 PAK2 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 CARD11 MALT1 ASB13 ASB14 ASB11 RNF6 ASB12 MAP3K14 RNF7 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 PAG1 WAS KIF23 PAK3 COLEC12 KIF20A ITGAV ITGB5 PDCD1LG2 B3GNT3 SPOP SUZ12 DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 GSK3B CD36 KLRK1 NCR2 BCL10 KIR2DS2 CD300LB TREM1 CD300E MAP3K8 KLRD1 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 TAB2 FOS NFKBIB AKT3 JUN PTPN22 CD209 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 UBE2L3 CD14 TLR4 LY96 HMGB1 IRF1 RPN2 TUSC3 RPN1 MAGT1 FBXL18 FBXL7 DNM1 OST4 LGMN DDOST TMEM258 DAD1 OSTC CANX STT3A STT3B KEAP1 DNM3 RNF123 LYN INPP5D PIK3CG PIK3R6 PIK3R5 SIAH2 BTK ARF1 CD40LG JAK1 TRIM4 IKBKG RIPK2 OSBPL1A PIK3CD PRKN CAPZA1 PSME2 PPIA AHCYL1 MAP3K7 VCP CXADR SMURF2 NFKBIA PTEN CD74 JAML CD99 TRAF6 BECN1 PIK3CB CAPZB NCK1 AKT2 CTSD HRAS PDPK1 PIK3CA PIK3R3 PIK3C3 TRIB3 SOS1 SH3RF1 PIK3R4 PIK3R2 PIK3R1 NRAS THEM4 PTPN11 ZAP70 CALM1 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 SEM1 KIF5C KIFAP3 HSPA5 KIF3B KIF3C KIF4B KIF4A TLR1 KIF11 S100A9 S100A8 KIF15 TLR2 KIF22 STX4 CD4 KIF26A TCF7L2 TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ATF3 TREM2 TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 SPTBN2 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CTLA4 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 C3 RICTOR CUL3 STAT1 KIF3A VCAM1 RBBP6 AP1G1 AP1S2 AP1S1 ITGB7 AP1S3 B2M AP1M2 AP1M1 AP1B1 TRIM32 HLA-A TRIM21 CD8B CD28 NEDD4 MKRN1 PLCG1 FZR1 SKP2 CDK4 BLK H2AX H2AB1 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 FBXO32 H2BC1 NFKB1 H2AC20 ITGAL MYLIP TRIM63 ITGA4 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 NCR3 CD200R1 HCST LILRA6 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 CD8A KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 FBXL21P WWTR1 CTSA YES1 CTSV CTSL CTSK DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 IL6 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 IL6R RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway DUSP9 DUSP4 PPP2R5B PPP2R5A DUSP6 PPP2R5D DUSP7 PPP2R5C DUSP10 NRAS UBA52 MAPK1 ARAF PEBP1 RAF1 DUSP16 MARK3 BRAP MAPK3 KSR1 BRAF UBB PPP2R1B PPP2R1A PTPN3 PTPN7 PPP2CA PPP2CB UBC RPS27A PPP5C PAQR3 YWHAB HRAS DUSP5 DUSP2 DUSP1 MAPK12 MAP2K1 MAP2K2 PPP2R5E DUSP8 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling IKBKB UBC TRAF2 RPS27A LRRC14 NLRX1 NLRC5 TRAF6 UBA52 USP14 CHUK TP53 CASP8 USP18 IKBKG UBB IKBIP MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 CPSF4 CPSF7 CPSF1 FUS CPSF3 CPSF2 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 CDC40 DHX9 CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 SYMPK RBM10 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants KIT CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression FASN MLX AGPAT1 ACACA ACLY MLXIPL ACACB EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells CLTC CLTB TIAM1 CLTA AP2A1 EPHB6 EFNB2 AP2A2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 AP2M1 EPHB3 APH1A PSENEN EFNA5 NCSTN EFNA4 APH1B PSEN2 CLTCL1 ADAM10 PSEN1 DNM1 EFNA1 EFNA3 EFNA2 MMP9 AP2S1 MMP2 EPHA2 AP2B1 EPHA5 EPHA4 EPHA7 YES1 EPHA6 RAC1 EPHA8 FYN VAV3 EPHA1 EPHA3 EPHA10 VAV2 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding NTHL1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2BC9 H4C9 H2BC8 H2BC5 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 H2AC1 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 SUZ12 H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 TRIM28 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 RBBP4 EZH2 DAXX NUP37 RBBP7 CBX1 PML H2AC19 H2BC26 DYNC1LI1 H2AC14 DYNC1LI2 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ELK1 ITGB1 H3C15 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type MMAA MMUT IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs IFNG MAPK1 RAF1 JAK2 JAK1 MAPK3 IFNGR1 IFNGR2 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n RFT1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SNAP25 RAB3A ARL6IP5 STX1A SYT1 SLC1A6 GLS2 SLC1A7 VAMP2 CPLX1 RIMS1 UNC13B GLS SLC38A2 PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC17A7 SLC1A1 TSPOAP1 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 RXRB NRIP1 PCK1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway CYP26A1 CYP26B1 CYP26C1 ADH1C DHRS4 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 ALDH8A1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN YES1 HCK SYK FYN ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A8 SLC22A12 SLC22A11 SLC22A7 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOF APOB LPA CETP MTTP P4HB SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea CACNA1D CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 TMIE USH1G STRC MYO15A CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation REXO2 FASTKD5 TBRG4 SLIRP PNPT1 FASTKD2 LRPPRC GRSF1 SUPV3L1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 DYNLL1 DCTN6 DCTN5 ACTR1A DCTN1 DYNLL2 PAFAH1B3 DCTN4 RAB6A CAPZA3 CAPZA2 PAFAH1B1 DYNC1I2 GALNT1 ACTR10 PLA2G4A CAPZB DYNC1LI1 DYNC1I1 RAB6B GALNT2 DYNC1LI2 DCTN2 DYNC1H1 CAPZA1 DCTN3 RAB3GAP2 PAFAH1B2 RAB3GAP1 BICD1 RAB18 BICD2 AGPAT3 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation YARS1 YARS2 NARS1 NARS2 RARS2 CARS1 CARS2 VARS2 MARS2 DARS2 RARS1 SARS2 LARS1 AIMP1 AIMP2 IARS2 QARS1 WARS1 WARS2 MARS1 DARS1 SARS1 EEF1E1 PARS2 KARS1 EARS2 LARS2 EPRS1 IARS1 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 FARSA FARSB FARS2 GARS1 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions CNTNAP1 CNTN1 NRCAM ANK1 SDCBP NFASC DCX TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 HMMR DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TPX2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED BTRC RBBP4 RBBP5 RBBP7 CDK4 H2AX H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DBT DLD DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA PAN3 PAIP1 PABPC1 PARN CNOT4 CNOT6 CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT6L CNOT11 EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 EIF4A3 PAN2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC LDLRAP1 PCCA HLCS CUBN MCCC1 AMN PCCB ACACB NUDT12 ABCD4 NADK SLC2A1 CYB5R3 PRSS3 THTPA TCN1 NMRK2 NMRK1 LMBRD1 NAXE NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MMAB MOCOS FLAD1 SLC22A13 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 QPRT SHMT2 MTRR SLC25A51 PARP10 PARP6 SLC25A19 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR CD38 GPHN PDZD11 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 DCAKD NMNAT1 COASY PPCDC SLC25A16 NUDT8 VNN2 NNMT PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 PNPO AOX1 TCN2 NAMPT CD320 SLC5A6 ACACA CBLIF MMACHC MMADHC FASN BST1 VNN1 GSTO2 SLC46A1 ABCC1 MTR SLC2A3 NAPRT PDXK GSTO1 NADK2 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L SLC5A8 MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP7 PIK3R4 FURIN DDX5 RB1 BECN1 HSPG2 VCP TMPRSS2 SDC4 SDC2 SDC3 AGRN ACE2 CHMP4C CHMP4B GPC1 CHMP4A ZCRB1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 CHMP2B CHMP2A NRP1 SDC1 CTSL VHL PIK3C3 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ILK PARVA ITGB1 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration ACO1 IDH1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes PRDX2 CYCS PRDX1 COX5B COX5A COX6C COX4I1 COX4I2 COX6A1 PRKAA1 COX6A2 PRKAA2 MT-CO1 PRKAG1 G6PD PRKAG2 PRKAG3 RPTOR COX6B2 COX6B1 COXFA4 TNRC6C MLST8 COX7A2 MOV10 RRM2B COX7A1 SLC38A9 HIGD1C AGO3 AGO4 PRKAB2 AGO1 TSC2 AGO2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC YWHAE MT-CO2 PTEN SESN3 MT-CO3 RHEB RRAGB SESN2 RRAGD LAMTOR2 AKT1 LAMTOR1 LAMTOR4 YWHAQ LAMTOR3 LAMTOR5 YWHAG GPX2 YWHAH GPI YWHAZ SFN GLS2 GLS TIGAR TP63 TXNRD1 AKT2 COX7A2L COX7B TP53 COX7C TXN COX8A COX8C AKT3 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CCNH PLK1 CCNB1 CDC25C CDK1 CDC25B FZR1 CDC25A CDK2 CDK7 MNAT1 PPP2R1B PKMYT1 PPP2R1A FOXM1 PPP2CA WEE1 HJURP PPP2CB PPP2R2A SGO1 PPME1 BORA OBI1 MIS18BP1 LCMT1 PPP2R3B TICRR XPO1 CCNB2 CCNA2 CCNA1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 F3 TFPI SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation ACD TINF2 TERF1 TERF2 POT1 TERF2IP STN1 TEN1 CTC1 PRIM2 PRIM1 POLA1 POLA2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB3 KCNN2 KCNMA1 KCNMB4 KCNN1 KCNN3 KCNN4 KCNMB1 KCNMB2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses PTPRS EPB41L3 HOMER3 NTRK3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN RTN3 LRFN3 APBA3 PTPRD APBA2 LRFN2 LRFN4 EPB41L1 LRFN1 STX1A SHARPIN LRRC4B SYT9 GRIA1 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 IL1RAPL2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 DLG1 CASK NRXN2 GRIN2A LIN7A SLITRK2 DLG2 LIN7C SLITRK1 DLG3 SLITRK4 LIN7B SLITRK6 DLG4 PDLIM5 GRIA3 NLGN4Y GRIA4 NLGN4X SYT10 SYT12 APBA1 SYT1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DBNL IL1RAPL1 PTPRF GRM1 GRM5 SLITRK3 SLITRK5 FLOT1 FLOT2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism MCCC2 BTD PC ACACA PCCA HLCS MCCC1 PCCB SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins PIAS4 NFKB2 RELA EIF2AK2 PIAS3 SUMO3 IKBKE NFKBIA UBE2I SUMO1 IKBKG TOPORS UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins HBEGF SNAP25 HSP90AA1 FURIN SYT1 CD9 HSP90AB1 SV2C SV2B SV2A TXNRD1 VAMP1 MAP2K4 STX1A VAMP2 MAP2K7 EEF2 STX1B GUCY2C SYT2 NHERF4 MAP2K1 MAP2K2 CALM1 PDCD6IP DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 NEU1 ALG14 ALG2 ALG3 B4GALT1 ALG13 ALG12 MAN1B1 ALG11 ALG1 MPDU1 DPAGT1 CTSA RFT1 MGAT2 MOGS GLB1 ALG8 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis CSPG4 HSPG2 SDC4 SDC2 SDC3 B3GAT3 XYLT2 AGRN XYLT1 B3GALT6 B4GALT7 GPC1 FAM20B UXS1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 PXYLP1 B3GAT2 B3GAT1 BGN DCN BCAN VCAN SDC1 CSPG5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed SENP5 SUMO3 SENP1 SUMO2 SENP2 SUMO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C8G C5 C6 C7 CLU C9 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism SLC26A2 SLC26A11 SLC26A1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 GNS HAS2 SPAM1 B4GALT6 B4GALT5 B3GALT6 B4GALT7 IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB SLC35B3 B4GAT1 SLC35B2 XYLT2 SLC35D2 XYLT1 FAM20B CHPF PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 B3GNT3 CHST14 HSPG2 PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 ACAN SDC2 SDC3 LUM HS6ST1 B3GAT3 HS6ST2 SGSH CD44 HS2ST1 HS6ST3 NDST2 AGRN NDST1 FMOD EXTL2 NAGLU B4GALT1 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DSEL DSE UST CHST15 ABCC5 ST3GAL4 SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 HMMR ST3GAL2 ST3GAL3 SLC9A1 CTSL CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer HBEGF RAC2 RHOG NTRK3 PIK3R2 NTF3 PIK3R1 PDGFB FGF20 FGF23 MET FGF22 PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 ESR1 ESR2 SRC NRG1 CD28 PIK3AP1 CD86 CD80 ERBB2 EGF PIK3CG EGFR TRAT1 PIK3R6 PIK3R5 KLB FLT3 IRS1 IRS2 PIK3CB STRN FGF1 FGF2 FGF3 PIK3CD AREG FGF4 FGF6 FGF7 FGF9 PDGFRA RAC1 LCK FYN PDGFRB NTF4 NTRK2 BDNF KIT TGFA GAB1 FLT3LG FRS2 HGF GAB2 EREG NRG3 PIK3CA PIK3R3 NRG4 NRG2 VAV1 BTC EPGN NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM SAMHD1 PNP ITPA NT5E ENTPD1 ENTPD5 ENTPD2 ENTPD3 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP3 CHMP6 CHMP7 UBA52 STAM STAM2 HGS VPS36 VPS25 UBB SNF8 UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer SOS1 UBC HBEGF RPS27A HSP90AA1 SHC1 AREG EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN UBB SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE TLR3 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport CYGB MB NGB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses GJA10 PANX1 PANX2 GJD2 GJC1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX ANAPC16 ANAPC7 UBE2C CSF1R VENTX UBE2E1 UBE2D1 RELA ANAPC10 ANAPC11 TCF7L2 CDC23 NFKB1 UBE2S CDC26 CDC27 CDKN2A LEF1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 CCND1 ANAPC2 CTNNB1 CEBPB EHMT2 EHMT1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B IL6 TP53 ANAPC15 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 FGF18 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FGF16 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport TRAPPC6A TRAPPC6B PREB SEC22A SEC22C STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 CTSZ NSF CTSC COL7A1 SAR1B SEC31A TRAPPC4 TMED10 SEC22B TMED2 SERPINA1 SEC23A GRIA1 CD59 F5 TFG F8 SEC24B SEC24A STX5 USO1 ANKRD28 SEC13 PPP6C PPP6R3 NAPA NAPB SEC24D RAB1A SEC24C RAB1B TRAPPC1 GOLGA2 NAPG CSNK1D GORASP1 AREG TRAPPC2L LMAN1L GOSR2 LMAN1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 TGFA SEC16A TRAPPC5 TRAPPC9 YKT6 CNIH1 CNIH2 SCFD1 CNIH3 MCFD2 PPP6R1 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME CYP2E1 ABCG2 GSTT1 GSTM1 ABCC2 GGT5 NAT1 GGT7 NAT2 SULT1A1 GGT6 ABCC5 CNDP2 SULT1E1 SULT1A4 ABCC3 GGT3P UGT1A10 GGT1 ABCC1 SULT1C4 ACY1 SULT2A1 GSTP1 ABCC4 SULT1A3 UGT1A6 UGT1A1 UGT2B15 UGT1A9 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling CSF3 STX4 TYK2 TXLNA CSF1R SNAP25 STX1A IFNLR1 STXBP2 VAMP2 IL34 IL16 PRTN3 IFNL1 SDC1 JAK1 PTPRZ1 IL32 CD4 STX3 IL10RB CSF3R CSF1 CASP3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 INS KIF5C SLC30A8 PCSK1 SLC30A5 STX1A KIF5B KIF5A MYO5A RAB27A VAMP2 MYRIP P4HB PCSK2 ERO1B EXOC8 CLTRN EXOC7 CPE DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 SPAM1 ZP1 B4GALT1 ZP3 ADAM21 ZP2 ADAM20 ZP4 OVGP1 ADAM30 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2E1 PTGR1 ALOX5AP CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions RPS6KA1 CLTC CLTA AP2A1 ITGA1 AP2A2 AP2M1 CNTN1 AP2S1 KIF4B AP2B1 KIF4A NCAN RPS6KA6 LAMA1 EGFR LAMB1 LAMC1 SPTAN1 NUMB SDCBP NFASC RAC1 NRP1 MAP2K1 MAP2K2 EZR ITGB3 ITGA2B SPTBN1 ITGB1 L1CAM VAV2 DPYSL2 ITGAV NCAM1 ITGA5 ITGA9 ALCAM SCN11A RDX SCN10A MAPK1 CHL1 ITGA2 LYPLA2 DNM1 DNM2 MAPK3 CNTNAP1 SPTB RPS6KA4 SCN1B SCN1A ANK2 ANK3 SHTN1 DNM3 SPTBN4 DLG1 SPTBN5 SCN3B DLG3 SCN3A SPTBN2 DLG4 CD24 SCN2A SCN2B KCNQ2 KCNQ3 SCN9A EPHB2 SCN8A ITGA10 SPTA1 CNTN6 RANBP9 SCN5A GAP43 DCX SCN4A SCN4B MSN NRP2 SCN7A CNTN2 NRCAM ANK1 SH3GL2 HSPA8 CSNK2A1 CSNK2A2 PAK1 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 PRKACA SLC8A1 SLC8A2 NOS1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D FXYD4 FXYD3 CAMK2A FXYD2 DMPK FXYD1 FXYD7 FXYD6 ATP2B4 RYR1 ATP2B3 RYR2 ATP2B2 RYR3 ATP2B1 TRPC1 SLC8A3 CLIC2 CALM1 CAMK2G TRDN ASPH ATP1A4 ATP1A3 ATP1A2 TNNI3 ATP1A1 PLN FKBP1B AHCYL1 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 OGG1 NEIL2 POLB LIG3 NEIL1 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation GP5 GP9 F9 GP1BA GP1BB F11 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PRKCA GFRA1 SOS1 GFRA3 GFRA2 SHC1 GFRA4 MAPK7 PIK3R2 PIK3R1 NRTN PLCG1 DOK2 DOK4 DOK5 DOK6 RAP1GAP PRKACG PRKACA PSPN PRKACB GDNF RET PTPN11 IRS2 PIK3CB PDLIM7 PIK3CD DOK1 GRB10 SHANK3 SHC3 GAB1 FRS2 GRB7 GAB2 PIK3R3 PIK3CA ARTN G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG GIP PRKACA PRKACB ADRB2 PTGIR AVPR2 GNAZ LHB PDE1B ADORA2B GNG3 PDE1A GNG2 RXFP1 GNG5 RXFP2 GNG4 GNG7 PDE11A GNG8 PDE2A ARRB1 ARRB2 PTH1R GPR39 PDE10A PTH2R GPHA2 GNAS NPSR1 CRH NPS GPHB5 LHCGR RLN2 RLN3 P2RY11 GCGR GCG INSL3 GPR84 PTH2 CRHR1 CYSLTR2 RAMP2 CALCA MC1R RAMP3 CALCB PDE3B MC4R CALCR CALCRL GPBAR1 MC3R ADM2 ADM IAPP FSHR GRK5 RAMP1 PTH MC5R PRKAR1B PRKAR2B PRKAR1A PRKAR2A ADRB1 HTR4 ITGB1 GPER1 HTR6 TAAR3P ITGA5 HTR7 CGA HRH2 DRD1 DRD5 PTHLH TAAR8 TSHR TAAR9 TAAR6 GNAT3 TAAR5 TAAR2 FSHB TAAR1 ADRB3 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PDE3A PDE8B PTGER4 PDE8A GRK3 GRK6 SRC ADCYAP1 PTGER2 ADCYAP1R1 PTGDR PDE4A PDE4D PDE4C GNAI3 ADORA2A GNAI1 GNAI2 PDE7B PDE7A CRHR2 TSHB POMC GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP AVP GRK2 GNG10 MC2R GNG12 GNG11 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) STAT5A STAT5B UBE2D1 SHC1 LYN STAT3 GRB2 UBA52 JAK2 JAK1 STAT1 KRAS SOCS1 UBB PTPN11 CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC GAB2 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNQ1 KCNE5 AKAP9 KCNH2 KCNE1 KCNA5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 FGF6 FGF9 PLCG1 FGF20 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 PPP2CA PPP2CB CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C AKT2 CTLA4 YES1 LCK FYN AKT1 PTPN11 PPP2R1B PPP2R1A PPP2R5E AKT3 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels STIM1 P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 P2RX4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling FGF2 TGFBR3 GIPC1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB ENSA MASTL PPP2R2D CCNB1 PPP2R1B CDK1 PPP2R1A ARPP19 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 SFTPD IL17RC IL17RA NLRP12 YWHAQ IL17F IL17A YWHAG GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 STAT2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E IKBKB YWHAB TRIM25 IKBKE AKT1 IRF7 NUP214 SFN YWHAZ IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C NUP42 NUP85 TPR NUP62 UVRAG NUP88 MAP1LC3B NUP43 RAE1 HSP90AA1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 NOD1 NOD2 AKT2 PDPK1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 TJP1 CHUK PTPN11 SIKE1 CREBBP PTPN6 IRAK2 SNRPG TAB3 TAB2 SNRPE IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria KHK MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT11 ACADL ACOT12 HADHB ACOT13 HADHA ACADVL ACADM ACSM3 ACADS PCCA ECI1 THEM4 PCCB ACSM6 THEM5 ACAD11 NDUFAB1 ACAD10 MCAT ACBD7 ACBD6 ACOT7L ACSF2 MCEE ACOT2 DBI PCTP ECHS1 DECR1 ACOT9 ACOT7 MECR ACAA2 MMAA MMUT HADH ACOT1 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 LMNB1 UBE2I TEX12 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B REC8 SYCP3 BRCA1 STAG3 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L H2BC21 SUN2 SUN1 H2AC8 H2AC6 H2AC7 H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 STAG1 H2BC11 STAG2 RAD21 ATR DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis RIPK1 TRADD TRAF2 RIPK3 CASP8 FADD MLKL DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) RELA NFATC1 MAP3K7 NFKB1 NRAS RASGRP1 NFATC2 CHUK IKBKB CARD11 MALT1 NFKBIA FKBP1A PSMD8 PSMD6 PSMD7 RASGRP3 PSMD2 REL NFKBIE PSMD3 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PPIA PSMC5 PSMC6 HRAS PRKCB SEM1 PSMC3 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB SKP1 NFKBIB PPP3R1 CUL1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2BC9 H2AZ2 H4C9 H2BC8 PIWIL2 H2BC5 TDRKH H2BC3 PIWIL1 HENMT1 H2BC1 ASZ1 MAEL MOV10L1 MYBL1 H2AC20 TDRD9 TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 DGCR8 TNRC6C TSNAX AGO3 PRKRA DICER1 AGO4 TARBP2 TSN AGO1 AGO2 TNRC6A TNRC6B POLR2A POLR2B POLR2C HSP90AA1 POLR2D POLR2E RAN POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L IPO8 ELAC2 H2AX H2AB1 H2AC19 H2BC26 ANG H2AC14 BCDIN3D H2BC12L XPO5 H2BC21 DROSHA PIWIL4 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 POU3F2 TNRC6C MOV10 AGO3 DICER1 AGO4 HDAC1 TRPM1 AGO1 AGO2 TNRC6A TNRC6B HINT1 BIRC7 BCL2A1 SIN3A PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 PLCG1 FGF20 FGF23 KLB FGF16 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs MAP1LC3B ULK1 RAB8B RAB33B RAB33A TBC1D2 RAB5B RABEP1 RAB5C TBC1D3 TBC1D7 RAB7B RABGAP1 RAB11A RAB6A ARF6 RAB4A RAB11B RAB5A RABGEF1 TBC1D10A TBC1D10B GABARAPL2 SYTL1 RAB7A RAB6B RAB35 GGA2 TBC1D24 GGA1 TBC1D25 OPTN GGA3 TSC2 RAB8A TSC1 TBC1D20 GABARAP TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 TBC1D10C CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC2A6 SLC2A7 SLC5A1 SLC2A8 SLC5A2 FGF21 SLC50A1 SLC2A4 SLC2A9 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A10 SLC2A11 SLC2A12 SLC5A10 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D GRIN1 RPS6KA6 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 RPS6KA3 RPS6KA2 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion UBC RPS27A FURIN VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A PPIA VPS37B MVB12B MVB12A UBAP1 NMT2 UBB PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG CETP APOA2 APOA1 APOA4 APOA5 APOE ANGPTL8 ANGPTL4 LPA MTTP LPL LMF2 LMF1 APOF GPIHBP1 FGF21 MBTPS1 APOC3 APOC2 ANGPTL3 ALB P4HB ABCG1 MBTPS2 APOB PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL PPP2CA PPP2CB PECAM1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PTPN6 MAPK14 LRP8 APOB PLA2G4A PTPN11 PPP2R1B FGR PPP2R1A PPP2R5E BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 ABCA3 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases RNF128 APC OTUD5 UBE2D1 TRAF3 ZRANB1 TRAF6 UBA52 OTUB1 RHOA CDK1 OTUB2 OTUD7A OTUD7B VCP IFIH1 NOD1 TRIM4 NOD2 VCPIP1 IKBKG UBB RIPK2 RIPK1 UBC RPS27A ESR1 TNIP1 MAVS TNIP2 TNIP3 OTUD3 RNF135 RIGI PTEN TNFAIP3 TP53 TRIM25 YOD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CYP51A1 SREBF2 MSMO1 NSDHL HSD17B7 TM7SF2 SREBF1 DHCR24 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome RELA NFKB1 HSP90AB1 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 PYCARD NLRP3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 PIP4K2C IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport ATP6V0D1 FTH1 ATP6V0C ATP6V0D2 ATP6V1B1 FTL ATP6V1A IREB2 ABCG2 CP FBXL5 ATP6V0A2 CYBRD1 ATP6V1H ACO1 ATP6V0A4 SLC40A1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HEPH ATP6V1F ATP6V1C2 ATP6V0A1 TF SLC46A1 STEAP3 HMOX1 HMOX2 SLC22A17 FTMT MCOLN1 STEAP4 TFRC HFE GLRX3 UBA52 UBB TCIRG1 CAND1 UBC LCN2 RPS27A NEDD8 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 SKP1 TFR2 ATP6V1B2 SLC11A2 CUL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 CRK PXN ARHGAP35 RASA1 NRAS RHOA ELMO1 RAC1 HRAS BCAR1 ELMO2 DOCK1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling CCND1 RUNX3 CTNNB1 TCF7L2 TCF7L1 MYC LEF1 TCF7 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 GRAP2 RICTOR MAP3K8 PPP2R1B PPP2R1A PIK3CB CDC42 PPP2CA PPP2CB MLST8 PIK3CD AKT2 CTLA4 MAP3K14 YES1 PAK1 PAK3 MTOR RAC1 LCK CD28 FYN PRR5 PDPK1 PAK2 AKT1 PIK3R3 PIK3CA VAV1 MAPKAP1 PPP2R5E AKT3 TRIB3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA RPS6KA1 SOS1 CCKBR HBEGF MAPK7 EGFR NRAS MAPK1 HRAS MMP3 MAPK3 GAST RPS6KA3 RPS6KA2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants FZD5 FZD4 WNT3A FZD6 LRP5 RNF43 FZD8 LRP6 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle LIG1 BANF1 XRCC6 FEN1 XRCC4 KPNA1 XRCC5 LIG4 PPIA HMGA1 CCR5 CXCR4 PSIP1 CD4 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E UBC RPS27A UBA52 UBB MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling RANBP10 HRAS SOS1 MUC20 MET RANBP9 HGF NRAS CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA1 NRAS MAPK1 MAPK3 RASGRF2 CAMK2B CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 RPS6KA6 PDPK1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RPS6KA3 CALM1 CAMK2G RPS6KA2 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX10 PPOX ALAS1 CPOX HMBS ABCG2 ALB UROD UROS ALAS2 COX15 ALAD FECH ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase CREBBP HSP90AA1 HSPA8 EP300 HSP90AB1 DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A FKBP4 HSPA1B SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins SOS1 STAT5A STAT5B CDKN1A PIK3R1 NRAS TRIP11 GOLGB1 PIM1 HRAS ZMYM2 GAB2 MYO18A PIK3CA ETV6 NOX4 SPTBN1 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH GNMT DAO PXMP2 GLDC AGXT HOGA1 GOT2 KGD4 GRHPR DDO HAO1 AGXT2 AMT DLST ALDH4A1 PRODH2 DLD FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate POU3F1 PAX6 ZIC2 ZEB2 SOX2 POU5F1 NANOG ZNF521 SOX1 GBX2 OTX2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN RNF146 PSMA5 PSMA6 PSMA3 PSMA4 AXIN2 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 TNKS PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A SMURF2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 AXIN1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT5 NUDT16 NUDT15 ADPRM NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling RGMB RGMA UNC5A UNC5B PLCG1 SIAH2 UNC5C UNC5D PITPNA AGAP2 WASL HJV SIAH1 PTPN11 CDC42 SLIT1 SLIT3 NEO1 DSCAM NTN4 MYO10 DCC DSCAML1 NTN1 TRIO NCK1 SLIT2 ROBO1 SRC RAC1 TRPC7 TRPC5 TRPC6 PRKCQ ABLIM1 TRPC3 ABLIM2 TRPC4 ABLIM3 TRPC1 PTK2 EZR DOCK1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A SS18 SMARCB1 SMARCD1 DPF1 BCL7A DPF2 BCL7C SMARCA2 BCL7B DPF3 SMARCA4 SMARCC1 SS18L1 ARID1A SMARCE1 ARID1B ACTB SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane SRPRB SEC61A2 SEC61A1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TRAM1 RPS3A RPS26 SRP54 RPS25 RPS28 SSR4 RPS29 SSR2 RPS20 SSR3 SRP9 FAU RPS21 RPS24 RPS27 RPS23 SRP72 SRP68 SRP19 RPN2 RPN1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL DDOST RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 SRP14 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 SEC61G RPLP0 SEC61B RPS27A SSR1 SRPRA SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A2 SLC17A1 SLC26A11 SLC4A7 SLC26A1 SLC20A2 SLC4A8 SLC4A10 SLC4A9 SLC26A4 SLC26A7 SLC26A3 SLC26A9 SLC26A6 SLC13A1 SLC13A4 AHCYL2 SLC12A3 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC4A2 SLC12A7 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 SLC12A6 SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC5A5 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin MAOA SLC6A4 ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME MAPDA NT5C2 ABCB1 ADH1A PCK1 ABCG2 SLC22A2 SLC22A3 SLC22A1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism CDA ADSL PPAT GMPS NUDT13 ADSS1 ADSS2 GART PAICS PFAS NT5C DCTPP1 AGXT2 NT5C1A DPYS NME2 DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP RRM1 RRM2B SAMHD1 DTYMK ATIC ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 TK1 ENTPD8 AK1 RRM2 AK2 NME1 AK4 AK5 AK6 AK7 AK8 AK9 GLRX NME3 NME4 DCTD CMPK1 TXNRD1 TYMS CTPS2 MAPDA CTPS1 GMPR2 GDA ADK AMPD1 NT5C2 NUDT5 GMPR DNPH1 AMPD2 AMPD3 NT5C1B NUDT16 DCK NUDT15 APRT ADPRM DGUOK PNP ITPA HPRT1 IMPDH1 IMPDH2 ADA UCKL1 UCK2 UCK1 PUDP TK2 NT5E ENTPD1 ENTPD5 TXN CAD DHODH UMPS GUK1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 STX1A SYT1 VAMP2 SV2C SV2B SV2A VAMP1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival IKBKB SQSTM1 UBC RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR UBB HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 MFN1 MFN2 KLC1 KLC4 IFNA10 KLC3 GUCY1B2 KLC2 GUCY1B1 IFNA21 ATP2A3 ATP2A2 IFNB1 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PLA2G4A FGR STIM1 KCNMA1 ORAI2 SLC16A8 PECAM1 ORAI1 SLC16A3 PDE9A PDE1B PDE1A KIF5B ITPR1 KIF5A ITPR2 SLC16A1 ITPR3 SRI PSAP LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS2 NOS3 PDE2A ATP2B4 VPS45 ATP2B3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 P2RX4 PDE10A P2RX3 CRK P2RX2 P2RX1 GNAS SERPINB8 S100A10 C1QBP CABLES1 RAB5A MMP1 SLC3A2 SLC7A11 EPCAM SLC7A10 PRKCB SERPINC1 RAC1 VAV3 SERPIND1 PRKCQ SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 VAV2 SLC7A9 IRF1 IRF2 NFE2 V2-11 V3-4 V3-3 MPL V2-17 THPO V3-2 V2-15 V2-19 V1-11 GNA13 V1-16 V1-13 CAPZA2 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 TBXA2R V4-6 V4-2 V4-1 SDC1 GATA3 LYN INPP5D PIK3CG PIK3R6 PIK3R5 CFL1 PF4 SERPINB2 ANXA2 MIF SOD1 CAPZA1 AAMP PPIA TUBA4A PRKCG TP53 PRKCE GNG10 GNG12 GNG11 GNG13 ITGA3 GNB2 GNAQ ITGA1 GNB1 MAFG ITGA6 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 WEE1 GNA14 OLR1 SPN VPREB3 VPREB1 GNG3 CXADR CDK5 GNA15 PSG1 PDPN PSG3 MPIG6B GNG2 SERPINB6 CLEC1B PSG2 GNG5 PSG9 GNG4 FCAMR GNG7 PSG8 GNA11 PSG5 GNG8 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 ARRB1 ARRB2 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD SH2B2 ANGPT4 ANGPT2 MERTK CD2 CD244 ITGAM ITGB2 PPP2R1B PPP2R1A PIK3CB CAPZB PRCP PFN1 GATA6 TFPI F13B HRAS PCDH7 ZFPM1 PDPK1 RBSN SIRPG GRB7 KIF18A PIK3CA PIK3R3 ITGB1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 NRAS GP1BA RHOA HBB RHOB KIF2A MAPK1 KIF2C KIF2B FCER1G CEACAM3 MAPK3 PTPN1 PTPN11 CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA PPP2CB CD58 ITPK1 CENPE DGKG SRC DOCK5 DGKE ACTN2 DOCK4 DAGLA DGKD DOCK3 DGKB DGKA ABHD6 ABHD12 PLAU PRKCH DGKZ SIRPA DGKQ DAGLB DGKK DGKI DGKH CALM1 DOCK2 DOCK1 VEGFB VEGFC VEGFD THBS1 VEGFA SELL GNA12 CSK JAK2 FGB FGA VWF PLAUR FGG APBB1IP TLN1 VCL CEACAM1 SYK RAD51B LCK FYN F7 APP F9 F13A1 RAD51C POTEKP PROC ISLR F10 LAMP2 PROS1 HABP4 FAM3C CHID1 F2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 KIF28P TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 KIF5C PDGFB A1BG CLU KNG1 KIF21A CYB5R1 KIF21B RASGRP2 KIFAP3 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A PRKACG RARRES2 IGF2 RAF1 IGHV3-23 PRKACA RAB27B PRKACB IGF1 RAPGEF3 PPBP IGLV CYRIB RAPGEF4 IGLV2-8 MANF SELP IGKV1-16 TF KIF16B IGKV1-17 SCCPDH IGKV1-12 KIF20B CALU IGHV3-7 MAGED2 IGHV3-9 HRG IGHV3-30 FERMT3 LGALS3BP IGHV3-33 SERPINA3 KIF3B IGKV1D-39 A2M ORM1 IGKV1D-33 ECM1 SERPINA1 KIF3C WDR1 IGKV2D-28 PLEK IGKV4-1 OLA1 KIF18B IGHV7-81 CTSW KIF4B ORM2 SERPINA4 IGKV2D-30 KIF4A TMSB4X IGHV4-59 ALB IGHV1-69 PHACTR2 KIF12 TIMP3 PHF21A KIF11 QSOX1 PRTN3 TIMP1 IGLV2-11 SRGN IGLV1-40 CAP1 IGLV1-47 TRPC7 KIF15 ABCC4 AHSG KIF19 IGLV6-57 ANXA5 IGLV2-14 F5 IGLV1-44 TRPC6 KIF13B PLCG2 F8 TRPC3 KIF1C IGKV3-15 MMRN1 KIF1B TOR4A IGKV3-11 IGKV2D-40 CD63 IGHV3-11 ITIH4 KIF1A IGHV3-13 ITIH3 PLG IGLV7-43 IGKV1D-16 TTN IGKV1D-12 CLEC3B KIF25 IGLV1-51 CDC37L1 SPP2 IGLV2-23 KIF22 STX4 RCOR1 KIF6 LEFTY2 IGKV3-20 IGHM KIF27 LY6G6F LHFPL2 PCYOX1L IGHV4-34 IGHV1-2 KIF9 CD9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 FLNA IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 HMG20B PPIL2 IGLC1 IGLC2 F2RL2 ADAMTS13 F2RL3 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 F2R IGKC LAT IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 KIF26A IGLC6 IGKV1-5 KIF26B PRKAR1B PRKAR2B PRKAR1A PRKAR2A P2RY12 P2RY1 HDAC1 ACTN1 SIN3A CDK2 ADRA2C ADRA2B F3 ADRA2A SH2B3 AKT1 SERPINE2 GATA4 JMJD1C GP1BB GATA1 F12 HBE1 PRKCD F11 ZFPM2 PRKCA GATA5 GP5 SERPINA5 AK3 YWHAZ GP9 MICAL1 KLKB1 CARMIL1 HBG2 HBG1 EHD1 EHD2 EHD3 MAFF HBD AKAP10 DOCK10 DOK2 AKAP1 SH2B1 CABLES2 GP6 ITGA10 MAPK14 RACGAP1 CAV1 CFD JAM2 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 KIF3A PDE5A DOCK11 EGF PLCG1 DOCK6 DOCK9 DOCK8 DOCK7 PLAT MYB H3-3B F11R H3C8 PRKCZ KIF23 BCAR1 KIF20A ITGB3 ITGA2B GATA2 L1CAM H3C15 ITGAV ITGA5 BRPF3 TNFRSF10B SPARC TNFRSF10A SERPINE1 TNFRSF10D ITGAX KDM1A GNAT3 ITGA2 ITGAL TGFB2 TGFB3 ITGA4 TSPAN7 MGLL HDAC2 PICK1 GNAI3 GNAI1 CBX5 GNAI2 CD36 ALDOA TREM1 MAFK PTPN6 YES1 BSG IGHA1 PTK2 IGHA2 IFNA5 IFNA4 IFNA7 JCHAIN IFNA6 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress JUN CCAR2 DNAJC2 DNAJC7 CXXC1 COX5B RPS19BP1 HSPA4L COX5A HSPA14 RELA HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 COX6C HSPA7 HSPA12A HSPA12B IFNB1 COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM IL6 APOB YWHAE GSK3A CDKN2D EED CDKN2C PDIA6 DNAJB11 CAT IGFBP7 WFS1 SOD2 CARM1 IL1A FBXL17 BACH1 PRKCI TLR4 DNAJC3 SLC7A11 LY96 MED1 OMA1 PRDX2 PRDX1 MAPK7 ADD1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 ATF6 DNAJA4 CRYAB DNAJA2 MAP3K5 CAPZA2 FKBP4 DELE1 HERPUD1 ACTR10 HSPA1B MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 SQSTM1 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 UBE2D2 UBE2D3 HIF3A KEAP1 LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 AR EGLN2 WTIP CDKN2B NPLOC4 NRF1 RPLP0 UBXN7 DPP3 HSPA9 UFD1 TALDO1 SOD1 CAPZA1 CSNK2A1 FKBP14 IGFBP1 GPX1 GOSR2 CSNK2A2 MYDGF EXTL1 TATDN2 LMNA SSR1 CSNK2B DNAJB9 SULT1A3 TSPYL2 ZBTB17 TP53 KLHDC3 DDX11 WIPI1 PGR YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB FKBP5 TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP MAP2K6 PRDX6 NLRP3 ESR1 CLEC1B MDM2 MDM4 GSTP1 NUP205 POM121 HMOX2 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 SMARCD3 NUP133 NUP210 HMGA1 NUP153 NUP93 HDAC6 NUP50 NUP35 RBBP4 NUP54 NUP37 RBBP7 STIP1 TXNRD1 TCIRG1 DYNC1LI1 CAPZB DYNC1LI2 AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 COX7A2L TXN RPS27 ATP6V1B2 EPO TRIB3 ATP6V0D1 CITED2 ATP6V0C ATP6V0D2 VENTX PPP2R5B ATP6V1B1 ATP6V1A SHC1 DYNLL1 ABCG2 DYNLL2 HBB ATP6V1H MAPK1 ATP6V0E2 NFYA ATP6V1G3 NFYB NFYC ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 DYNC1I2 BMAL1 MAPK3 COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A HM13 EIF2AK3 NOX4 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 HSPA6 UBE2D1 HSPE1 ANAPC10 HSPD1 ANAPC11 VEGFA CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN TLN1 RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 SKP1 CCNA2 ATM CCNA1 ATR CUL1 CXCL8 CREB3L3 NUDT2 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 HSPA5 HSBP1 CHD6 GPX3 HSF1 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 DEFA5 BTRC RPS4Y2 RPS27L RPS4Y1 ATOX1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A STOML2 RPS16 GCN1 WDR59 RPS19 PHB2 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT YME1L1 RPS10 DEPDC5 RPS13 KPTN WDR24 RPS12 RPS9 SH3BP4 RPS7 FNIP1 RPS8 FNIP2 RPS5 KICS2 CASTOR1 RPS6 CASTOR2 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 CDKN1A CDKN2A HSP90AB1 SIN3A CDK2 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS PRKAA2 SEC31A EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 RPTOR ATF3 ATF4 TNRC6C CALR MOV10 MLST8 SLC38A9 ID1 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 TXNIP HMOX1 RRAGC MT-CO2 PSMD7 MT-CO3 RHEB RRAGB XPO1 PSMD2 RRAGD KHSRP AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 NUP214 LAMTOR5 DIS3 IDH1 PRKCD NCF1 PSMA5 NCF2 PPARGC1A PSMA6 NCF4 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 ACTR1A DCP2 SERP1 PSMD12 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 CYBB PSMB4 EXOSC5 CYBA PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 CUL7 HSPA8 DCTN2 ADRM1 DCTN3 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PGRMC2 PSMC4 PSMC1 PSMC2 SIRT1 HSPA1A SIRT3 PPARA CYCS HMGA2 H1-1 H1-0 H1-3 CUL3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A TRIM21 HSPH1 HYOU1 HBA2 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 HIGD1A H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 HSP90B1 KDM6B H3C15 RXRA ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 STAT3 H3-4 H2BC1 POT1 NFKB1 TERF2IP H2AC20 RPL4 RPL5 HDAC3 RPL30 RPL3 RPL32 RPL31 RPLP1 NRIP1 RPL34 RPL10L COX4I1 RPL8 COX4I2 RPL10A TBL1X RPL6 RPL7 NCOA1 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 NCOR2 ARNT RPL39 RPL21 RPL23 NCOR1 RPL22 BMI1 TBL1XR1 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RNF2 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 CRTC2 CRTC3 CRTC1 CLOCK MAP2K3 NPAS2 HELZ2 MAP2K4 RAI1 CREBBP MAPKAPK3 SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 TGS1 MEF2D MAP2K7 MAPK10 COX7B FOS GFPT1 FOXO3 COX7C EDEM1 SYVN1 COX8A COX8C AKT3 HIKESHI KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB MECR HADHA ECHS1 ACADM HADH SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs NTRK1 KIDINS220 SOS1 CRK SHC1 NGF MAPKAPK2 NRAS RALA MAPK1 RAP1A MAPK3 BRAF RAPGEF1 MAPKAPK3 MAPK14 MAPK11 YWHAB SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 FRS2 RIT1 MAP2K1 RIT2 CRKL MAP2K2 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection SNRNP200 HDLBP SRSF6 KDELR1 SRSF7 AP2A1 SNRPB AP2A2 SRSF9 DDX5 BAG2 PRPF8 AP2M1 CLU CPSF4 CPSF1 APOA1 HSPA5 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 PRKG2 CD209 RTN3 CHERP ISY1 AP2S1 DDX46 DDX42 YBX1 PTBP1 AP2B1 HAVCR1 BCAS2 P4HB RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 IPO7 PUF60 DNAJB11 U2AF2 P4HA1 P4HA2 SNRPB2 CD14 P4HA3 SMNDC1 DNAJC10 NMT1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 KPNB1 PPIL3 PPIL4 TLR4 DNAJC3 HNRNPA1 STAT2 LY96 RPSA MAPKAP1 PDCD6IP FASN C4BPA C4BPB RPN2 TUSC3 ATG14 RPN1 HSP90AB1 MAGT1 CTNNB1 DNAJA2 C4B_2 OST4 SDC4 ATG7 HSPA1B SDC2 DDOST SDC3 TMEM258 RPTOR DAD1 OSTC CALR CANX ACOT2 MLST8 STT3A STT3B EIF4E GPC1 GPC3 UBE2I GPC2 MRC1 GPC5 SUMO1 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 XPO1 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D XRN1 LYN POLR2E POLR2F POLR2G PABPC1 POLR2H UBA52 POLR2I POLR2J NPLOC4 POLR2K POLR2L H2AC25 NEK2 H2AC21 PDIA3 GTF2F1 CLDN1 GTF2F2 IFIH1 UFD1 UBB UBC RPS27A HSPA8 UBA7 UBA6 UBA5 UBR4 NRBP1 HSPA1A KPNA2 EIF4G1 PEX19 RNASEK ATL2 LY6E KPNA7 NACA KPNA4 HNRNPA0 TIMD4 KPNA5 CD2BP2 KPNA3 HNRNPUL1 TYRO3 BTF3 FURIN AUP1 UBA3 PPIL6 MAPRE3 EMC4 UBA1 ELAVL2 RICTOR H2AC1 CPSF7 SPCS3 SRRM1 SPCS2 VCP CLINT1 SPCS1 SEC11A SEC11C VIM HNRNPC RIPK1 RBMX STING1 NFKBIA SCAP MAVS HYOU1 CLEC5A MAP1LC3B HSP90AA1 KPNA1 H2BC18 MERTK BECN1 DAXX EIF4E3 H2AC19 AXL H2BC26 H2AC14 EIF4G3 EIF4G2 H2BC21 SUN2 TSG101 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 PIK3R1 CDC40 H2AC20 DHX9 HSPG2 CD33 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 CD300A HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 DPM1 SF3A1 DPM2 SF3A2 DPM3 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 RRBP1 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN NCL WBP11 PRPF6 SNRPG SRSF2 PROS1 PPIE NFKBIB SRSF3 F2 SNRPE GAS6 SRSF4 SNRPF SRSF5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases MMP15 COL18A1 MMP17 KLKB1 FURIN CMA1 ELANE CTSG PRSS2 MMP8 MMP9 KLK2 MMP25 MMP1 TIMP2 MMP2 PRSS1 CTRB2 SPOCK3 CTRB1 TIMP1 MMP3 CTSV MMP24 TPSAB1 MMP7 MMP13 CTSK MMP10 PLG MMP11 MMP14 MMP16 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling SOS1 CRK SHC1 FN1 RASGRP2 RASGRP1 RAP1B RAP1A CSK FGB RAPGEF3 FGA RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 AKT1 PTK2 ITGB3 ITGA2B METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY CBS MAT1A NNMT GNMT CTH SCLY HNMT SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport SLC10A6 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C CAMK4 GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL CALM1 CAMK2G ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D GNS CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CYSLTR1 CCL2 EDNRA OPN3 CCL1 RRH EDNRB CCL19 PTGIR PROK2 CCR2 RGR CCL17 AVPR2 PROK1 AVPR1A CCL16 OPN5 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 LPAR4 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 GPR17 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP LPAR6 CMKLR1 NMS PDYN NMU AGTR2 GNRH2 FPR3 GNRH1 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 GPR132 CCKAR GNRHR GPR183 FFAR4 PNOC FFAR3 GPR18 FFAR2 SSTR3 GPR39 EDN1 GPR37 ANXA1 EDN2 GPR35 EDN3 GPR31 CCKBR GPHA2 NPSR1 GRP GPR55 PTAFR NPS GPHB5 PLPPR1 PROKR1 LHCGR PLPPR2 PROKR2 MTNR1A PLPPR3 KISS1R MTNR1B MCHR1 PLPPR4 P2RY10 RLN2 PLPPR5 P2RY11 RLN3 LPAR1 ECE1 LPAR2 GPR4 ECE2 LPAR3 PRLHR LPAR5 MT-RNR2 INSL3 F2RL1 CHRM2 INSL5 S1PR1 PENK F2RL2 CHRM3 S1PR3 F2RL3 CHRM1 S1PR2 APLN GPR37L1 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 KEL PMCH NLN CYSLTR2 PPY MC1R GHSR MC4R OXGR1 F2R GPBAR1 LTB4R2 MC3R UTS2 GAL NTS FSHR MCHR2 NPB OPN4 NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R LTB4R NPY1R APLNR SUCNR1 BDKRB2 HCAR2 BDKRB1 HCAR3 QRFPR GNRHR2 HCAR1 XCL2 XCL1 PYY HTR2B HTR2C HEBP1 ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 ADORA3 ADRA1A CCK ADORA1 HRH1 GPER1 HCRTR2 HTR6 HCRTR1 TAAR3P NPY5R KISS1 HTR7 SSTR1 CGA HRH3 SSTR2 HRH2 HRH4 SSTR4 DRD1 SSTR5 DRD2 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 DRD5 HTR1E CNR2 TAAR8 CNR1 HTR1F TSHR TAAR9 OPRD1 ACKR1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 FSHB ADRA2C C5AR2 HTR5A ADRA2B TAAR1 C5AR1 ADRA2A GPR143 C5 ADRB3 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR ADORA2A AGT TSHB PF4 C3 FPR1 FFAR1 ADRB2 OPN1LW LHB ADORA2B OXER1 OPN1MW RHO NPY CXCR1 CXCR2 OPRM1 SST OPN1SW OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis MUC15 MUC13 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC3 MUC1 ST6GALNAC4 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 MUC12 ST6GAL1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX F9 F10 F8 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria BID CASP8 GZMB NMT1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling RPTOR EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B YWHAB RPS6 MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation KPNA1 H1-1 H1-0 DFFB H1-3 DFFA HMGB2 HMGB1 H1-2 H1-5 H1-4 KPNB1 CASP3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) PCNA POLH MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR FIGNL1 UBA52 FIRRM BLM MRE11 RTEL1 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 RFC5 UBC RMI2 POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE RMI1 POLD2 RFC2 RFC1 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C POLE4 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 POLE2 POLE3 ATR RAD9A RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy MAP1LC3A FUNDC1 ATG5 CSNK2B MAP1LC3B ATG12 ULK1 CSNK2A1 CSNK2A2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH12 RDH8 RBP1 LRAT STRA6 TTR RDH5 RLBP1 RDH11 ABCA4 RDH10 RDH16 SDR9C7 RPE65 RHO MYO7A DHRS9 CYP4V2 RBP3 HSD17B6 HSD17B1 RBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 HSP90AB1 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSBP1 PTGES3 HSF1 HSPA2 CRYAB VCP FKBP4 MAPK3 HSPA1B RPTOR MLST8 CAMK2B HSPB8 CAMK2D HSPH1 CAMK2A MTOR YWHAE NUP205 AKT1S1 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C CAMK2G NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 HSP90AA1 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 NUP37 HSPA9 CREBBP EP300 HSPA8 RPA1 RPA2 EEF1A1 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes NCAPH CSNK2B SMC4 SMC2 CCNB2 CCNB1 NCAPD2 CSNK2A1 CDK1 NCAPG CSNK2A2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G IQGAP1 FAM114A2 QKI KIAA1549 ESRP1 TRIM24 FXR1 FN1 AGTRAP ARAF AP3B1 PEBP1 CSK AGGF1 JAK2 TENT4A MARK3 FGB FGA VWF KSR1 FGG BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation NR1H2 CLTC PCSK9 NR1H3 UBC AP2S1 CLTA AP2A1 VLDLR RPS27A AP2A2 AP2B1 UBA52 AP2M1 MYLIP UBB DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME UGT2B7 SLCO1B1 SLCO1B3 GSTA1 ABCC2 XDH GGT5 GGT7 GGT6 CNDP2 GGT3P GGT1 SLC16A1 ALB ACY1 SLC22A3 GSTP1 ABCC4 CES1 SLC22A2 SLC22A1 CYP2C9 CYP2C8 CYP2C19 MAPDA ADK AKR1C1 PNP CYP2D6 HPRT1 SLC22A7 IMPDH1 ADA IMPDH2 SULT2A1 CES2 SLC28A2 RAC1 SLC29A1 VAV3 SLC29A3 SLC29A2 SLC28A3 VAV1 VAV2 CYP2E1 HSD11B1 ABCG2 HSD11B2 GMPS TPMT GSTT1 UGT1A3 PCK1 GSTM1 NME2 SERPINA6 SULT1A1 SULT1E1 ACSM2B SULT1A4 ABCC3 ABCC1 SULT1C4 BCHE PON3 PON1 NME1 NAT1 NAT2 SLCO1A2 ABCC5 NT5C2 ABCB1 NUDT15 ADH1A GSTA2 UGT1A10 ITPA UGT2B28 UGT1A5 UGT1A4 UGT3A2 SLC22A8 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 BSG GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A CYP3A4 ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 GUK1 UGT2B4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi MAN1C1 MAN1A2 MGAT1 MAN1A1 MANEA RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCA NCF2 NCF4 RAC2 PIK3R4 NOXA1 NOXO1 NOX3 MAPK14 PRKCZ MAPK11 NOX1 PRKCB MAPK1 RAC1 S100A9 PIN1 S100A8 CYBB CYBA MAPK3 PIK3C3 PRKCD NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 RPS27A FGF4 CBL FGF9 UBA52 FGF20 MKNK1 SPRY2 MAPK1 FGF23 FRS2 MAPK3 BRAF PTPN11 UBB FGF16 PPP2R1A KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway MAFG RELA PGD NQO1 GSTA3 MUL1 GSTA1 SESN1 SRXN1 CHD6 CUL3 VCP CCL2 ABCF2 SOD3 G6PD GCLC GCLM TRIM21 SESN2 MAP1LC3B EGF BTRC SKP2 FBXL17 BACH1 PRKCI TXNRD1 SLC7A11 EP300 AKT2 TXN NOTCH1 PRDX1 NFKB1 CDKN1A ABCG2 CDKN2A PRKAA2 SQSTM1 ATF4 TKT ABCC3 MYC ABCC1 PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 EIF2AK3 AMER1 GSK3B IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 NPLOC4 PSMD11 ME1 PSMD14 UBXN7 PSMD13 PSMA7 BRCA1 PSMB6 PSMB7 PSMB4 DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 BCL2 PSMB1 PDGFA MAFK RPS27A AREG NFE2L2 BCL2L1 ADRM1 CSNK2A1 PALB2 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 CUL1 AKT3 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CREBBP PER3 CRY2 CRY1 BMAL1 CSNK1D KMT2A CSNK1E CLOCK NPAS2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency GSS RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle TFRC VANGL1 WDR11 SLC4A7 UACA RHOH TMEM59 JUP TUBA1B ROCK1 ARHGDIB ROCK2 CSK RALGAPA1 FAM91A1 VCP NSFL1C DBN1 VAMP3 RAB7A SLC1A5 NIPSNAP2 PAK6 ARHGDIG STOM PAK1 PAK5 LCK MTR ARHGDIA PAK2 ZAP70 LAMTOR1 PAK4 OSBPL11 DBT CAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A PACS1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLCO4A1 SLC26A2 SLC22A5 SLC17A1 SLC24A2 SLC24A3 SLCO2B1 SLC41A2 SLC5A1 SLC26A11 SLC41A1 SLC5A2 SLC30A10 SLC16A2 SLC39A6 SLCO1B1 SLC39A5 SLC26A1 SLCO1B3 SLC39A8 SLC15A1 SLC39A7 SLC14A1 CTNS CP SLC39A2 SLC15A3 SLC14A2 SLC6A5 SLC39A1 SLC15A4 SLC4A10 SLC39A3 SLC2A9 SLC30A8 SLC26A4 SLC30A3 SLC26A7 SLC30A2 SLC26A3 SLC31A1 SLC26A9 SLC30A5 SLC26A6 SLC40A1 SLC39A10 SLC25A1 SLC2A1 SLC30A1 SLC2A2 SLC6A2 SLC39A14 SLC13A1 SLC6A3 SLC8B1 SLC8A1 SLC13A2 SLC22A12 SLC8A2 SLC13A3 HEPH SLC13A4 SLCO1C1 SLC2A10 SLC47A2 SLC47A1 SLC5A12 SLC5A10 SLC25A26 SLC24A4 SLC16A7 SLC16A8 EMB SLC11A1 SLC16A3 SLC13A5 FGF21 RSC1A1 AHCYL2 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 SLC24A5 SLC22A4 SLC22A3 SLC22A6 SLC45A3 SLC10A6 SLC22A15 SLC22A16 SLC22A11 SLC20A1 SLC8A3 SLC2A6 SLC2A7 SLC2A8 PDZD11 SLC50A1 SLC4A8 SLC4A9 SLC6A20 SLC35B3 SLC43A2 LCN9 SLC1A1 SLC35B2 SLC43A1 SLC27A1 SLC1A2 SLC35B4 SLC3A1 SLC35D1 SLC1A3 SLC35D2 SLC1A4 LCN15 SLC3A2 LCN12 SLC7A11 SLC7A10 SLC35A2 SLC1A6 SLC35A3 SLC33A1 SLC1A7 SLC5A6 SLC7A1 ARL2BP SLC7A3 LCN1 SLC25A29 SLC29A4 SLC38A3 SLC27A6 SLC38A2 SLC28A2 SLC36A4 SLC29A1 SLC38A5 SLC2A13 SLC28A1 SLC38A4 SLC29A3 SLC36A1 SLC5A11 SLC6A19 SLC5A3 SLC29A2 SLC28A3 SLC38A1 SLC27A4 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC5A5 SLC32A1 SLC6A13 SLC20A2 SLC6A1 SLC6A9 SLC17A6 SLCO1A2 SLC1A5 ARL2 SLC67A1 SLCO4C1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 SLC22A7 SLC12A2 RUNX1 SLC12A4 SLC6A7 SLC12A5 SLC12A7 SLC6A11 SLC25A18 SLC25A11 SLC6A4 APOD SLC17A7 SLC25A22 SLC2A3 CALM1 SLC35C1 SLC4A7 SLC25A10 SLC24A1 SLC17A5 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 AVP SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC2A4 SLC35A1 SLC22A8 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 BSG SLC5A9 SLC12A6 SLC60A2 SLC39A4 SLC34A3 SLC5A4 SLC34A2 SLC2A14 SLC34A1 SLC2A11 SLC11A2 SLC2A12 SLC5A7 SLCO2A1 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 CDK2 MLH1 FIGNL1 TEX15 MSH4 MSH5 MND1 FIRRM BLM MRE11 BRCA1 BRCA2 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 H2AC19 H2BC26 H2AC14 SPO11 H2BC12L H2BC21 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 H2BC11 ATM H3C15 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation JUN IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 HRAS VAV3 VAV1 VAV2 SOS1 V2-11 V3-4 NRAS V3-3 V2-17 IGHE V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 MAPK8 MAPK3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN MAP2K4 MAPK9 SYK PAK1 MAP2K7 MAP3K1 MAPK10 FOS PAK2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 HES5 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 TACC3 MAMLD1 PSEN1 RBPJ SMAD3 ACTA2 SNW1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 FLT4 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A HEY1 KAT2B KAT2A EP300 HEY2 JAG1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 MAML3 NOTCH2 NOTCH1 CUL1 NOTCH4 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EED UXT PCGF6 RRM2 EPC1 CDC7 E2F1 RBBP4 EZH2 BRCA1 RYBP RBBP7 TFDP1 TFDP2 CHEK1 RBBP8 YAF2 EHMT2 EHMT1 MAX BMI1 CBX3 RING1 L3MBTL2 RNF2 E2F6 SUZ12 RAD51 PHC1 CBX5 MGA PCGF2 PHC3 APAF1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 GLRX5 FDX1 FXN SLC25A28 FDX2 SLC25A37 LYRM4 FDXR HSCB RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport CYCS MT-ND6 COX5B COX5A MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 COX6C TMEM126A UQCRC2 TMEM126B TRAP1 SURF1 COX6A1 COX6A2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 COX6B2 NDUFAF2 SFXN4 COX6B1 NDUFAF3 NDUFAF1 HIGD1C HCCS TMEM186 RAB5IF OXA1L ACAD9 COQ10B COQ10A TMEM177 DMAC1 DMAC2 UQCR11 UQCR10 PET117 TIMMDC1 PET100 MDH1 MDH2 NUBPL LETM1 LYRM2 LYRM4 LYRM7 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 NDUFAB1 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 COX18 HIGD1A UQCRH COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 UQCRFS1 COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 MT-CO1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 BCS1L COXFA4 NDUFA6 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 COX19 TTC19 COX17 UQCRHL SCO2 MT-CO2 MT-CO3 CYC1 NDUFS3 GOT2 HSCB ECSIT HSPA9 TIMM21 SLC25A12 FXN SLC25A13 NDUFB8 COX7B COX7C COX8A COX8C FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm TBX6 BMP4 LEF1 MAMLD1 CTNNB1 MESP2 DLL3 HES7 MSGN1 RBPJ RIPPLY2 SNW1 EPHA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 NOG PSMD11 PSMD14 PSMD13 WNT3A PSMA7 PSMB6 FGFR1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP MAML2 PSMB1 MAML1 KAT2B KAT2A LFNG EP300 ADRM1 TBXT PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 MAML3 NOTCH1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 SEL1L MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 CP MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 RNF185 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 DERL1 MRPL45 DERL2 MRPS6 RNF5 MRPL46 MRPS5 OS9 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 ARF4 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 EXOC8 EXOC7 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 EXOC4 MRPL12 EXOC3 MRPL57 EXOC6 MRPL13 EXOC5 MRPL54 EXOC2 MRPL10 EXOC1 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 GBF1 MRPL21 MRPL22 KGD4 RAB11A MRPL30 MTRES1 MTRFR NDUFAB1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN PIAS3 DDB1 UBE2V2 COPS7B XPC COPS7A CUL4A COPS3 COPS6 COPS5 UBE2N COPS8 BDH1 OXCT1 HMGCS2 ACAT1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 CAPZA3 CAPZA2 ACTR10 SQSTM1 TFAP2B TFAP2C TWNK UBE2I SUMO1 SSBP1 EIF1AX EIF4H UBE2D2 EIF3M UBE2D3 EIF3K HIF3A EIF3L EIF3I ELOB EIF3J ELOC EIF3G RBX1 EIF3H EIF3E EPAS1 EIF3F CUL2 EIF3C HIF1A EIF3D VHL EIF3A EIF3B GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 EIF5A FBXL5 DHPS WRAP53 FN3KRP TUBA8 GNGT1 EIF5A2 TUBA1C FN3K ICMT TUBA1B GNGT2 DOHH TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 KLK13 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 NUP37 CDC20 MT-ND4L PARS2 MRTFA EARS2 LARS2 PPA2 DYNC1LI1 PPA1 TARS2 DYNC1LI2 TARS1 AARS1 AARS2 HARS1 HARS2 CDCA8 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 TCF25 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 DYNLL1 CARS2 VARS2 RANGAP1 ANKZF1 KLHDC10 DYNLL2 TSFM EIF5B RHOA MARS2 DARS2 INCENP EEF1G BIRC5 SARS2 NEMF EEF1D MTRF1L EEF1A1P5 MTIF2 PRMT3 MTIF3 DYNC1I2 IARS2 WARS1 WARS2 AURKB DYNC1I1 DYNC1H1 TFG GOLGB1 GLUD1 NFKB2 ANK1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ACE2 LAMB2 FN1 LAMB1 LAMC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 RPS20 LRR1 CCNF FAU RPS21 UBE2L6 RPS24 B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B ASCC2 ASCC3 CDC34 SFTPA2 PSME1 FSHB INHBB UBE2J2 INHBA INHA INHBC INHBE SEC31A SIAH1 FBXL8 EIF4EBP1 CALR FBXL4 EIF4E EIF4B LRRC41 GAN RRAGA KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 CUL7 CUL5 UBA6 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H YKT6 KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 SEC61A2 SEC61A1 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 GALNT1 CALCA ARFGAP3 ARFGAP2 IAPP MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 TPST2 SEC16A KTN1 TPST1 TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RPL4 RPL5 RPL30 RAD52 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A MATN3 RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 CHD3 RPL23 BMI1 RPL22 RPL13A SUMO3 RPL9P9 SUMO2 RING1 RPL37A PIAS1 RPL24 HDAC4 RPL27 HDAC2 RPL26 L3MBTL2 RPL29 SATB1 RPL28 SATB2 RPL10 RNF2 RPL12 ZBED1 RPL11 RPL36A SUZ12 CBX8 RPL14 PHC2 RPL13 PHC1 RPL15 CBX5 RPL18 CBX4 RPL17 PCGF2 RPL19 CBX2 RPL39L PHC3 RPL41 AMER1 RPL35A RPL23A RPL3L AXIN1 RPL27A RPL22L1 APC ABCE1 RPL26L1 CDC73 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 RWDD3 UBA2 SAE1 CREBBP AREG NFE2L2 SAA1 TGFA EIF2AK2 MGAT3 APEH HEMK2 ETF1 GSPT2 GSPT1 APOB MME CES1 USO1 TUBB8 RAB2A TUBB8B EIF2B5 EIF2B4 EIF2B3 EIF2B2 RAB1A EIF2B1 RAB1B HGS RAB5A TOP2A GORASP1 STARD7 FDX1 OMA1 OPA1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 FUT8 MITF GANAB MAN2A1 MGAT5 MGAT1 MGAT2 OST4 EDEM2 MOGS ARF3 ACHE DDOST MGAT4C HTRA2 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 LONP1 TRRAP CCP110 BCHE KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 AGT USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PIAS4 VDAC1 CFTR GATA3 BRCC3 SNX3 RHOT1 RCE1 ZRANB1 SIAH2 INO80 STAM TADA2B CYLD H2AC25 H2AC21 BAP1 WDR48 OTUD7A OTUD7B RAB4A BABAM1 IFIH1 BABAM2 UCHL1 TRIM4 UIMC1 UFD1 IKBKG TOMM70 RIPK2 ACTL6A JOSD2 UCHL3 JOSD1 ALAS1 UCHL5 DDB2 KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 USP17L21 USP17L20 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 SFTPC USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 ECI1 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 CLSPN SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 STAR USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 USP25 USP26 USP20 USP21 RAB32 USP22 RAB35 TAF10 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 HADH RAB39B RAB8B RAB33A RAB7B RAB21 CHML RAB11B RAB12 RAB13 ARG2 ALPI HNRNPK PIGS PIGU PGAP1 PIGT GPAA1 PIGK OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 CDH2 METTL21A KIN MYO5A METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT MYRIP EEF1AKMT2 EEF1AKMT1 DDX5 FFAR4 GRP U2AF2 GALNT11 GALNT14 GCG GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNTL6 P2RY2 ADRA2C COL7A1 ADRA2A MDC1 MT-CO1 B4GALT1 DTL MT-CO2 MT-CO3 GATA4 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 FOXL2 HIC1 SP3 ALDH2 PPARG PPARA LY6E MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 BGLAP SPP1 SUCLG2 UQCRC2 OGDH MT-ATP6 RORA FH DLST ATP5PF ATP5PD MDH2 ATP5F1C MT-ATP8 ATP5PO NDUFA13 SOCS3 NDUFV3 ATP5MG NDUFV1 IDH2 UQCRQ MT-CYB ETFB ME2 IDH3A FBXO32 SFTPB SFTA3 SFTPA1 NDUFS1 NDUFB6 COX4I1 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 RABGGTB ADGRF5 RABGGTA NDUFA2 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 EEF2 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NR5A1 PCNA COX5B COX5A RELA NPM1 NR3C1 NPPA KLK3 SP100 KLK2 RAB9A RAB9B KIF5B KIF5A VDR IL6 PCSK2 ERO1B CPA3 CDX2 LEP ENPEP CPB1 SENP5 CLTRN SENP2 NOP58 TRIAP1 ACE CPE REN CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 IGFBP2 SHISA5 PDIA6 PAPPA MXRA8 SPARCL1 IGFALS AURKA SCG2 KLK1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A ZNF131 FUCA2 UHRF2 DDX17 HRC CASP8AP2 MELTF MBD1 SERPINA10 SAFB MIA3 MSLN TOPORS PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 B4GALNT2 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 TOP2B TOP1 SERPIND1 GOLM1 POFUT2 GZMH NUCB1 NOTUM POFUT4 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 PRELID1 LYPD8 LYPD6B PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CPB2 LRRC49 PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 CHM TTLL1 TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H ING2 SPRN SPACA4 NICN1 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 RAB22A CD59 CD52 CD55 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 RAB40A ZNF350 RAB40B RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 RAB29 RAB15 RAB19 RAB17 TTLL10 NFU1 TTLL13 MEN1 TTLL11 TTLL12 IGFBP1 UMOD LIAS OTOA RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FUCA1 WDR5 RAB3D RAB44 RAB31 RAB37 RAB5B RAB5C HDAC7 RAB6A TRAPPC1 RBBP5 RAB4B RBBP7 FCGR3B KLF4 PML MSRA PCMT1 MSRB2 MSRB3 MSRB1 TTR RAB24 RAB10 TSPAN14 RAB18 ANPEP TXN COMMD9 PARP1 BST1 VNN1 CTSZ CTSH CTSC COMMD3 KCTD6 NR4A2 SRP14 THRB CGB8 COPB1 NR2C1 THBS1 HSPD1 ADA2 POMC ATP6AP2 FGA PLAUR FGG CAND1 F7 F9 PROC F10 GGCX PROS1 PROZ F2 GAS6 DBT DLD PCSK9 APOA2 APOA1 APOA4 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB BTRC ADAMTS13 MTA1 HSD17B10 EPRS1 TRMT112 SOCS2 SOCS6 IKBKE CETN2 ACTR1A CSNK1D DCTN2 DCTN3 JMJD6 RIOX2 ANO8 RNF168 ANKRD28 ASPH PPP6C PPP6R3 TP53BP1 COP1 SMC1A SMC3 STAG1 STAG2 RAD21 TDG DCAF13 PRL CALB1 NAT8B BACE1 APCS TSPAN33 GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI ITM2B CSF2RB CSF2RA NCOA2 PNPLA2 TTF1 CTBP1 DNMT1 DNMT3B DNMT3A SLC30A8 SLC30A5 STS ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD SFTPD TUFM UBE2L3 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MARS1 DARS1 SARS1 EEF1E1 GSN KARS1 IARS1 UBE2T OTULIN ALDH1B1 APH1A PSENEN NCSTN APH1B ADAM10 FBXL18 FBXL7 SDC2 TMED2 GPC3 ADORA2A UCN MBOAT4 PLA2G7 CRHR2 GH1 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 TSHB DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF1 NPLOC4 DDA1 RPLP0 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CISH CUL9 DPP3 HSPA9 UBD NAE1 SOCS5 WDTC1 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B CAPZA1 NEURL2 ERCC8 PSME2 GOSR2 SSR1 ARFGAP1 SRPRA SRPRB PREB KDELR3 PCCB PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 RWDD1 SEC11A JMJD4 KDM8 SEC11C JMJD7 RIOX1 OGFOD1 DRG1 DRG2 RCCD1 ZC3H15 ADORA2B SHMT2 STX5 CMA1 IDE CAPZB GATA6 CTSD TFAM SCFD1 SPTBN1 PARK7 MUC13 INS FGF23 ABCA3 GRIA1 CKAP4 SENP1 CALM1 NDUFS3 UBE2C UBE2E1 UBE2D1 PDHB UBE2S CDK1 DLAT BLM PDK1 BRCA1 PDHA1 WRN BARD1 FBXW11 RPA1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 RAB41 KIF5C KNG1 COG8 COG7 COG6 COG5 IGF2 COG4 RAB27B COG3 CTSG IGF1 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG LTF MAN1A2 F5 TMED3 F8 MMRN1 MAN1A1 TMED7 PLG TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B ARF5 NAPA NAPB GOSR1 NAPG GOLGA2 LYZ BPIFB2 MAN1C1 SEMG1 SPG7 GALNT2 AFG3L2 ARCN1 SMDT1 YME1L1 PMPCA MICU2 COPG2 COPG1 LTBP1 TCF7L2 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A CHCHD2 CTNNB1 EIF2S2 EIF2S1 EIF2S3 ECH1 SPTB ACOT2 STX1A MYC LDHD ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 SPTBN5 PSMD2 PSMD3 SPTBN2 PSMD1 NUP214 CS PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ACO2 PABPC1 UBA52 PSMD12 SEC61G PSMD11 TIMM17A PSMD14 SEC61B PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 TIMM22 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 PSMC5 PSMC6 TIMM9 PSMC3 PSMC4 PSMC1 PSMC2 TIMM10 EIF4G1 ATP5F1A ATP5F1B PEX10 PEX12 SRD5A3 C3 PEX13 PEX14 FURIN IL33 RNF20 CCT2 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC CCT7 B2M HLA-A VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT CCNE2 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 H2BC11 RARA H3C15 RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 HDAC3 KDM1B GNAT3 NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 FBXL21P ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 SLC34A2 MRPS17 SLC34A1 MRPS15 MRPS16 MRPS14 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR BTRC JAK2 SKP1 RBX1 CUL1 PTPN11 GH1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 ALOX15B PTGS2 ALOX15 GPX2 GPX1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix MMP15 COL18A1 MMP17 MMP19 TMPRSS6 NID1 FURIN CAPN8 SPP1 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 CTSG HTRA1 SCUBE3 PRSS2 SCUBE1 BMP1 KLK2 MMP25 A2M TIMP2 ADAM17 SPOCK3 CAPN13 TIMP1 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 DCN TLL1 BCAN PLG LAMA5 LAMB3 CMA1 ELANE LAMA3 ADAM8 LAMB1 LAMC2 LAMC1 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST MMP1 MMP2 CTSD MMP3 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 NCSTN COL23A1 HSPG2 ADAM10 PSEN1 ACAN COL9A1 CD44 COL9A3 COL9A2 CDH1 CTSS ADAMTS4 ADAMTS5 ADAMTS1 ADAMTS8 ADAMTS9 KLKB1 ADAMTS16 ADAMTS18 MMP8 MMP9 PRSS1 PHYKPL CTRB2 CTRB1 OPTC KLK7 CTSB BSG CTSV MMP20 MMP24 CTSL TPSAB1 MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 CASP3 MMP16 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT5A STAT5B STAT3 IL22 JAK3 STAT4 JAK2 IL20RA IL20RB IL22RA2 JAK1 STAT1 IL22RA1 IL10RB PTPN11 TYK2 IFNLR1 IL20 STAT2 IL26 IL24 IL19 IFNL2 IFNL1 IFNL3 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers JUN ADCY9 NTRK3 NTF3 ADCY4 ADCY3 PDGFB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 IRAK1 ITPR2 ITPR3 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PRKAR1B PRKAR2B PDGFRA PRKAR1A RAC1 PRKAR2A PRKX KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PRKCD PRKCA PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 AHCYL1 PSMC4 PDE1C PSMC1 CSNK2B CAMKK1 PSMC2 CAMKK2 GRK2 KPNA2 PRKCG TP53 PRKCE NBEA CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 PLCG1 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 CAMK2B ESR2 CAMK2D HDAC2 SRC NR4A1 CAMK2A NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 CALM1 GSK3B CAMK2G IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK CAMK4 FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 TGIF2 EED POMT2 POMT1 PRKCI RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures MUS81 FIRRM BLM SLX4 RTEL1 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 PGM1 GALM DHDDS DPM1 NUS1 DPM2 DPM3 GALK1 MPI GALE PMM2 GFPT1 DOLK GNE GALT POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events PRKCA GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 ADRA2C RGS4 ADRA2B RGSL1 ADRA2A GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCB GNAI3 RGS20 PRKCH RGS17 GNAI1 RGS19 PRKCG PRKCQ GNAI2 PRKCE RGS16 GNG10 GNG12 PRKCD GNG11 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G2D PLA2G2E PLA2G3 PLA2G5 PLA2R1 PLA2G10 LPGAT1 PLA2G4F PLA2G12A PLA2G4D PLA2G4B PLA2G2A PLA2G1B LPCAT4 CRLS1 PLA2G2F LPCAT1 PLA2G4A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse PLXNB1 ERBB2 RHOC SEMA4D RHOA LIMK2 RHOB LIMK1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MYH10 MYL9 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 PTEN EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 AKT2 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 TRIB3 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A THEM4 PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PHLPP2 PIP5K1C PHLPP1 CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN AKT3 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism ALDOB GLYCTK SORD KHK ALDH1A1 TKFC AKR1B1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria ASL KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF28P KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIF5C KIF21A KIF21B KLC1 KIFAP3 KLC4 KIF2A KLC3 KLC2 KIF2C KIF2B KIF16B KIF3A KIF20B KIF3B KIF3C KIF5B KIF5A KIF18B KIF26A KIF4B KIF26B KIF4A KIF12 CENPE KIF11 KIF23 RACGAP1 KIF15 KIF19 KIF13B KIF1C KIF1B KIF18A KIF20A KIF1A KIF25 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes CREBBP PRDX1 ATF4 MAFK SLC7A11 GCLC NFE2L2 EP300 GCLM NQO1 GSTA3 GSTA1 SRXN1 CHD6 HMOX1 TXN SOD3 BACH1 TXNRD1 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease SOS1 CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 NRAS TRIM24 PLCG1 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 HRAS ZMYM2 GAB1 FGFR1OP2 FRS2 GAB2 PIK3CA SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC PHOSPHO1 CHPT1 ABHD3 PCYT1B PCYT1A CHAT CHKB CHKA STARD10 MFSD2A ACHE LPCAT1 PCTP LPIN1 LPIN2 LPIN3 CSNK2A1 CSNK2A2 CEPT1 BCHE CSNK2B STARD7 PEMT SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PLCG1 FGF20 FGF23 FGF22 FGF16 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency CPS1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CHTOP ALYREF DDX39B SRRM1 DHX38 NXF2B NXT1 UPF3B MAGOHB RNPS1 NUP205 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency BTD LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs RHOC PPP1R12A RHOA LIMK2 RHOB PAK1 LIMK1 ROCK1 MYL12B ROCK2 MYL6 MYH9 CFL1 MYH14 MYH11 MYH10 MYL9 PPP1R12B PPP1CB DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) UBC TICAM2 TICAM1 RPS27A TBK1 IRF3 TRAF3 OPTN LY96 UBA52 CD14 IKBKE IRF7 TANK PTPN11 UBB TLR4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription HES1 HDAC5 CCNC HDAC1 UBA52 HES5 TLE4 HDAC3 HDAC8 TLE2 HDAC9 TLE1 HDAC6 HDAC7 HEYL MAMLD1 TBL1X UBB RBPJ CREBBP UBC CDK8 MAML2 NCOR2 MAML1 RPS27A HEY1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 EP300 SNW1 HDAC11 MYC HEY2 HDAC4 HDAC2 SKP1 RBX1 MAML3 NBEA HIF1A NOTCH1 CUL1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines NSD2 KMT5C SUV39H1 MECOM H4C9 RELA EED SMYD3 NFKB1 ATF7IP SETD1B SETD1A AEBP2 RBBP4 NFKB2 EZH2 RBBP5 PRDM16 RBBP7 KMT2D PRDM9 EHMT2 EHMT1 ASH2L KMT2C KMT2B SETDB2 SUV39H2 SETD2 SETD3 SETD6 SETD7 H3C8 ASH1L DOT1L SMYD2 NSD3 SUZ12 NSD1 DPY30 SETDB1 WDR5 KMT2A KMT5A H3C15 KMT5B METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway GOT1 MRI1 MTAP APIP ENOPH1 ADI1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes JUN PMS2 MLH1 CDK12 CDK13 FANCI MDC1 ATF2 FANCC FANCD2 CCNT2 ELOB ELOC CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L MSH2 GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 BRCA1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 CHEK1 NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 DDB2 CDK9 TCEA1 RAD51D FOS TP53 ATM ATR FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation SERPINA5 CD177 THBD F13B PRTN3 SERPINC1 F13A1 PROC F10 SERPIND1 F5 FGB PROS1 F8 PF4V1 FGA F2 SERPINE2 FGG PF4 F2R PROCR RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB8B RAB43 RAB14 RAB41 RAB33A RAB7B RAB21 RAB27B CHML RAB11B RAB12 RAB30 RAB13 RAB36 CHM RABGGTB RABGGTA RAB9A RAB6B RAB9B RAB39A RAB22A RAB3D RAB40A RAB40B RAB44 RAB40C RAB3A RAB33B RAB31 RAB2A RAB37 RAB5B RAB5C RAB3B RAB3C RAB42 RAB11A RAB6A RAB1A RAB2B RAB1B RAB4A RAB4B RAB34 RAB5A PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB7A RAB29 RAB32 RAB15 RAB35 RAB19 RAB17 RAB27A RAB38 RAB24 RAB8A RAB10 RAB18 RAB39B 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4F3 CYP4A22 CYP4B1 CYP2U1 CYP2S1 CYP4F2 CYP2W1 CYP2D6 CYP4A11 CYP3A43 CYP4F22 CYP4F11 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle ARHGEF9 ARHGAP26 OBSCN MPP7 VANGL1 ARHGAP32 ARHGEF7 ARL13B RHOQ TRIP10 CDC42 CPNE8 STEAP3 GJA1 FNBP1 SCRIB GFOD1 LAMTOR1 IQGAP1 TFRC IQGAP3 SNAP23 CFTR ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 GOPC SYDE1 ARHGAP33 OPHN1 GIT1 WASL PLEKHG3 DEPDC1B CDC42EP1 VAMP3 RAB7A CDC42EP4 CDC42EP3 CDC42EP2 ITSN1 ARHGAP17 SLC1A5 ARHGAP21 PREX1 STOM PAK1 CDC42BPB SRGAP2 CDC42BPA PAK2 DLC1 PAK4 DIAPH3 GIT2 CAV1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol TRIT1 ADAT2 TRMT6 TYW5 TRMT61A TYW3 TRMT5 TYW2 TYW1 LCMT2 ALKBH8 THG1L TRMT44 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B EPRS1 TRMT13 TRMT11 QNG1 TP53RK WDR4 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 URM1 LAGE3 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress CXCL8 DCP2 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EXOSC4 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP DIS3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome HBEGF PXN AREG EGF PIK3R1 EGFR SRC CSK TGFA GAB1 EREG PIK3CA BTC PTPN11 EPGN PAG1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 RBX1 NOTCH1 CUL1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A3 SLC22A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints PLK3 CDKN1A CDKN2A CDC25A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 CHEK1 PSMB5 CSNK1E CCNE1 NEK11 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 TP53 CCNA1 ATM CUL1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB ACADL HADHA SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAP2K1 MAP2K2 MAPK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN DOCK3 RAC1 GRIN2B NTRK2 BDNF SRC MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN PRP4K ZCRB1 WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina PRKCB PRKCA EMD LMNB1 LPIN1 CCNB1 LPIN2 LPIN3 CNEP1R1 CDK1 LEMD3 LEMD2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response OAS1 OAS3 ABCE1 RIGI RNASEL FLNA OAS2 PDE12 OASL PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane TMEM258 DAD1 OSTC STT3A STT3B RPN2 TUSC3 PDCD1LG2 B3GNT3 RPN1 PDCD1 MAGT1 MIB2 OST4 JAK1 CD274 DDOST RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 CDC42 KLC4 RAC1 KLC3 KLC2 KTN1 KIF5B RHOG KIF5A RHOA KLC1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins LY6E CD109 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 BST1 LYPD6B PIGO VNN1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH ALPI LY6K GPIHBP1 LY6D LY6H SPRN SPACA4 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 CD52 PRND CNTN5 CEACAM5 ALPL CNTN3 CNTN4 ALPG TEX101 GPLD1 GP2 PRSS21 PRSS41 DPM1 DPM2 DPM3 TECTA TECTB VNN2 PIGS PIGU PGAP1 PIGT GPAA1 PLET1 CPM PLAUR PIGK PSCA MELTF RTN4RL2 MSLN FCGR3B RTN4RL1 OTOA RAET1G RAET1L IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM FOLR2 ULBP2 OPCML NEGR1 XPNPEP2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 MYO6 AP2M1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation CYB5B NOSTRIN HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NOSIP WASL DNM2 NMT2 AKT1 ZDHHC21 CALM1 CAV1 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB PDHX FH SUCLA2 MPC1 SUCLG2 HEL-S-133P SUCLG1 GPT DHTKD1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN3 COMP MATN1 COL9A1 COL9A3 COL9A2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 TGFB1 STAT3 ENPP2 RHO LPA CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC4 TUBA2 PSMC1 STUB1 TUBA8 UBE2L6 PARK2 UBE2L3 HEL-S-89n TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD5 PSMD2 RNF19A TUBB1 PSMD3 PSMD1 GPR37 FBXW7 HEL-S-103 TUBB HEL-S-72p CASK SEPT5 TUBA4B TUBA4A TUBB2A CCNE1 PSMD10 PSMD12 PSMD11 HEL-S-91n TUBAL3 PSMD13 HSPA14 UBE2J2 UBE2J1 TUBA3E SNCA HSPA4 SIAH2 SIAH1 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B TUBB4A PSMC6 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 INSR PDX1 PDGFA BRAF IGF1 FOXM1 TGFBR1 FOXO1 IGF1R INS RAB43 RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways RGS16 CAMK2A ADCY3 ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G CORIN GUCA2B GUCA2A RGS10 ACKR3 RGS11 RAMP1 ACKR5 ACTA2 ATF1 ATF2 MYLK2 HEL2 OXTR CRCP GABPB1 ETS2 SLC8A1 RXFP2 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 IGFBP1 PRKCH IGFBP5 PRKCB IGFBP4 PRKCE IGFBP2 PRKCA DGKZ MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA LPAR1 HEL-S-14 ITPR2 PRKCZ CRHR1 CNN2 GRK5 GRK4 CALD1 PLCG2 SFN PLCG1 IGFBP6 JUN GNG12 GNG11 NFKB1 GNG13 PKIB IL6 SP1 PKIA GNB2 MAFF GNB1 GNAS GNB4 GNB3 RLN1 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADM OXT ARRB2 RYR3 GNGT1 YWHAQ PS1TP5BP1 PDE4B HEL-S-1 YWHAG GABPA HEL-S-21 PDE4D FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 RGS17 CAMK2D RAMP2 RAMP3 RGS14 ATF6B 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2I2 HEL-S-71 NRROS TFRC CEP19 HFE SLC40A1 PIGX H2BC21 UBXN7 SMCO1 DYNC2H1 NCBP1 DYNLT1 NCBP2 DYNLT3 ADAM10 SLC51A SLC51B SIRT1 DYNLL2 FNDC8 RNF168 PIGM MFI2 DYNLT2B PXN MYCBP2 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 ZDHHC19 BRINP1 STAT5B TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP WDR53 ZNF76 TF DYNLRB2 NF2 DNCL1 HAMP TGFB1 JUN FBXW7 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 E2F3 MYC PIK3R1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 PARP1 NAMPT TFAM HIF1A PPARG FOXO3A ROS1 SIRT1 SIRT3 FOXO1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 MAPK1 MAPK3 PIK3R1 SLBP CBL FGF2 ERI1 NSD2 TMEM129 CLTCL1 NELFB UBE2J2 FAM53A NELFCD NELFA POLN H3F3B FRS2 CKAP5 LETM1 NICOL1 TACC3 GRB2 NAT8L SOS1 FGFR3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2C MEF2B CCND2 NKX2-5 KLF4 MEF2D CAMK2D MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers ADM CRP PBR GRN CCL23 CCL11 BDNF TREM2 DBI S100B TREM1 CX3CL1 IL6 GFAP CCL5 IL1B OLR1 TNF CHI3L1 NEFL CCL2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 APOB LDLR PLTP USF1 GPIHBP1 LPL GHR LIPC EPHX2 APOA2 PCSK9 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies IL6 C1QB C1QA CD40 IL25 CD80 C4B_2 C2 C4A CD19 IL12B TNLG7A IL12A IL6R HEL-S-62p CD40LG IFNG IL23A IL17F IL17D IL17C MS4A1 IL17B CD22 IL17A C1QC EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1H1 DYNC2H1 DCTN1 TRAK1 ATAT1 DYNC1LI2 RHOT1 SYPL1 CASP3 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A SNCA DYNC2I2 CASP8 RAB3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome VCP IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 E2F4 CIMAP3 SNAPIN PTCH1 CEP19 RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 DNM3 TFDP2 SMO RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 STX5A IFT25 RABL2B SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 SMAD4 HEL113 TNC RUNX2 CDH6 CDH2 ID1 SNAI1 SNAI2 CDH16 AKT3 MAPK1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR2 TPH2 TPH1 KDM3A GRIN1 CHRM1 KDM1A KDM1B CYP27B1 CALB1 RXRA KDM6B NR1i1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 HEL-75 CYP27A1 GCLC KCNQ2 BCL2 SLC8A1 KCNQ3 PVALB NFE2L2 CACNA1C GRIN2B VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway HADHB CYP2C9 CYP2A6 HSD17B10 CYP2B6 HDAC1 EHHADH IVD ABAT ACADSB FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis TFRC SLC40A1 CYBB GCLC STEAP3 CISD1 SAT2 SLC7A11 BACH1 MAP1LC3A MAP1LC3C AIFM2 FTH1 SLC39A8 HEL-S-64p HEL-S-102 SLC38A1 GPX4 ACSL1 SLC11A2 ACSL6 FACL4 ACSL5 ACSL3 TF SLC39A14 POR DKFZp762B153 CHMP6 CHMP5 FTL IREB2 ALOX15 SLC3A2 HMGCR DPP4 FTMT CBS PCBP1 PHKG2 HMOX1 FDFT1 ATG5 PRNP AKR1C1 AKR1C2 CP COQ2 LPCAT3 VDAC3 CTH GCLM NOX4 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX1A SLC25A4 NAPA SNAP25 SLC22A3 STXBP1 CLTC DNM3 CACNA1B CLTA SLC1A3 CACNA1A AP2A1 CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 AP2S1 SLC17A6 SLC17A7 SLC17A8 CLTCL1 STX2 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B UNC13C UNC13A SYT1 SLC32A1 SLC38A1 SYP SYN2 SYN1 STX1B STX3A VAMP2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IFITM3 ANKRD13C CREBBP HDAC2 CADM1 IRS1 TET2 EP300 PIP4K2A HDAC1 NOL9 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG GATA3 GATA2 KLF15 KLF2 PPARG DDIT3 CEBPA CEBPB EGR2 KLF5 CEBPD ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins DKFZp762B153 RB1CC1 RAB7A ATG5 PRKAA2 CALCOCO2 HEL-S-30 PPP1R9A RPTOR LARP1 MTOR ULK1 DEPTOR LAMP2 MLST8 VPS11 APOB VPS39 EIF4B VPS16 ATG3 VPS18 GABARAPL2 VPS33A RPS6 ATG9A ATG12 VAMP8 TMEM59 RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 NBR1 LAMTOR1 SQSTM1 ATG2B OPTN INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 GRN SIRT1 RHEB MYCBP2 RB1 SMEK1 ZMYND8 NAB1 DHTKD1 MAP3K7CL AHR STK11 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 CSNK1D TSC1 ARAF PPP4R3B BAX MYT1 RHO CCNB1IP1 CDC25B PIAS1 MSH6 EDAR MSH2 LGALS13 BLM MAX RASGRP3 RAP1A RRAS NUP85 TPR BARD1 CASP8 UBE2F SMAD1 PLK3 APOBEC3G GADD45A PIK3R2 XRCC3 PLK1 ERAL1 SMAD6 SMARCA4 FADD FOSL2 FOSL1 FER CDK7 NOXA1 NF1 MDM2 ATM ZNF655 MAP3K13 CERK BMPR1A ATR PIGR GSK3A BMPR2 GDI1 TRADD PTEN BRCA1 BRCA2 RASGEF1A RAC1 JAK1 ANXA1 DCAKD TGFBR2 ITPKC USP15 RALA USP16 SELENOK TFPI SMAD2 EGFR SMAD4 AURKA PAK1 BAK1 STAT1 USP21 MRE11A BRAF PML HIPK2 VEGFA TGFBR1 MAP3K7IP1 FOXO1 WEE1 RAD50 RAD51 FILIP1 CTNNB1 FAU CDK4 MYC IRS1 CDK2 MAPK1 KRAS ATF1 BCL2 HDAC1 BACH1 CASP9 CASP3 CHUK HMGCR JUN NFKB1 SP1 PKIA BAD MTOR CDC42 CREB1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP9 CASP3 APAF1 BAX TNFRSF1A NEF3 TOMM40 SLC1A2 DERL1 HEL-S-2 TNF NEFH NEFL MAP2K6 MAP3K5 GPX1 BAD HEL-S-44 MAPK14 MAP2K2 CCS SMIM40 RAB5A BCL2L1 BCL2 PPP3CA CASP12 RAC1 PPP3CC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism RELA INSR CRP CBS INS NFKB1 IL6 CCL5 TNF CCL2 CTH HEL-S-44 SCARB1 APOB SERPINA3 LDLR MTRR SAA4 HBB APOE MTR PLAT PLG HEL-S-51e MPO MCEE ABCA1 FGA CUBN CBLIF HBA2 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG TCN2 TCN1 IL1B ALB SAA1 SAA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 HEL-S-30 HEL-75 EHHADH PDHX FH HEL-S-133P SUCLG1 HEL-S-64p PNMT HEL-S-32 HEL-S-61p DBH FTCD GLS TDO2 HEL-S-53e PDK4 ACADM PIG59 HEL-S-4 ARG2 RARS1 ARG1 GPT2 MCCC1 CAD SDHA HEL-S-26 CBS ACLY LARS2 SMS BCAT1 ALDH7A1 DLD DDC ADH1C PPM1L MAOA HDC ADH7 CTH ADH5 GCLM SRM HMGCL TPO PCK1 ACSS1 PDHA1 MDH2 GOT2 ASNS ASS1 CS GLUD1 G6PC2 HAL PC TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 IARS OTC FARSB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 TDO2 IDO1 FOXO1 KLF5 CDKN1A IFNB1 IFNG AADAT HEL-S-90n HAAO TNF IL1R2 EIF2AK1 AHR EIF2AK4 KMO KYNU AFMID IDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling ITGB1 HEL-S-130P PRL HEL-S-69p PAK1 RPS6KA2 SIRPA RELA STAT1 NEK3 CISH GAB2 PRLR VAV1 VAV2 ZAP70 PPIB SRC SHC1 AGAP2 SOCS2 MYC SOCS3 SOCS1 IRS1 ERBB2 EIF4EBP1 MAPK1 FLNA FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 NFKBIB RAF1 RPS6 RPS6KB1 PXN STAT5B GSK3B MAPK9 MAPK8 CASP3 STAT3 JUN PIK3CA NFKB1 MTOR PIK3R2 PIK3R1 CBL YWHAG FOS YWHAZ RAC1 JAK1 HRAS GRB2 SOS1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap ETHE1 MAT1A SQOR SUOX CDO1 MTR HEL-S-64p CTH HEL-S-61p CBS GCLC COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system CRP CSNK1A1 FCN1 FCN2 CLEC4M CD40 ITGB3 PLG PROS1 ITGA2B ICAM2 F13A1 C2 C4BPA C4A FGA LAMC1 CD19 C8A FCGR3A IBSP RPS19 C1QBP PRKCA HEL-S-62p HEL-S-78p C3AR1 VSIG4 MBL2 CR2 CR1 ALB CD93 ITGA2 HEL-S-92n PLAUR DCN FCER2 SERPING1 MASP2 MASP1 CD46 CFD LAMA5 FKBP2 SELPLG SFTPA2 CFH C5AR2 CFI C5AR1 WAS FPR1 GNAI3 TXN HEL-S-99n CFP THBS1 CPN1 VTN PRNP GNA15 C6 C7 C9 SPP1 CD59 CD55 ELANE F10 F11 LAMB1 SELE SELP SELL CFHR2 ADM CFHR4 PTX3 ARRB2 SFTPA1 KLKB1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC34A3 ATP6V1G1 SLC6A19 ATP6V0B ABCC2 SLC6A18 SLC36A2 ATP6V0E1 SLC34A1 SLC16A10 SLC3A2 ATP1B1 SLC9A3 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ABCG2 ATP6V1B1 SLC47A2 ATP6V1A SLC22A6 ABCB1 SLC47A1 SLC22A2 SLC1A1 SLC2A2 SLC3A1 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 SLC5A5 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1D ATP6V1C1 ATP6V1F SLC22A11 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACTA2 COL1A1 RAF1 SMAD4 TGFB1 CTGF TGFBR1 NOX4 HIF1A RRAS SP1 IL11 JUND MAPK1 IL11RA MGRA MAP2K6 ACE2 PTPN11 COL1A2 TGFBR2 PDGFD AGTR1 IL6ST OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH3 NOTCH1 DMP1 HNF1A BMP7 KLF4 DSPP ALPL RUNX2 SP7 SOST CTNNB1 DKK1 NOTCH2 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies GSK3B SMAD2 CREBBP TGFB1 RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 WNT7B CEBPD CTNNB1 CDK4 MAOA SPP1 APC CSNK1A1L NOTCH1 PPARG WNT10B HDAC1 LEF1 TNFRSF11B PS1TP5BP1 ZMPSTE24 FNTA CTSK LMNA HES1 EMD JUNB HES5 TCF7L2 CDKN1A TCF7L1 ICMT RB1 HMGA2 DICER1 LEMD3 TARBP2 GDF8 KAT2B BMP2 MYOD1 AGO2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG MAFK COX1 NFE2L2 PTGS2 CYP2A6 VEGFA JUN FOS NFKB1 IKBKB NFKBIA KEAP1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members GSK3B CREBBP EP300 CHUK ZC3HAV1 RELB TBK1 IKBKG BTRC SKP1 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CLDN6 MAVS MAP3K14 RIGI NFKBIA ERN1 PARP1 NFKB2 IKBKB LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS TLR4 ICOSLG CD40 CD80 TNLG7A IL6 CD40LG IFNA2 TNFRSF13C BCR TLR9 IL17A TLR7 PDCD1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 TGFBR1 IL10RA SLC7A7 LHFPL2 HIMAP2 GAPT NRROS GPX1 RGS1 HEL-S-62p C1QC SPP1 CD84 ITGAM FKBP15 NCF2 PLEK LOXL3 TCIRG1 PPP1R18 CXCL16 PYCARD LYL1 RPS6KA1 CREB3L2 ITGAX CD37 GAL3ST4 IL13RA1 RNASE6 IL18 HEL-S-66 TNFRSF1B RUNX3 LGALS9C APBB1IP MAF TYROBP BIN2 ELF4 NPC2 DPYD EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance EGFR PDGFA NRAS BRAF IGF1 VEGFA IGF1R SRC KDR SHC1 PDGFRA PDPK1 MYC HGF AKT3 RRAS2 NRG1 ERBB2 NRG2 EIF4EBP1 MAPK1 SOS2 KRAS MET MAPK3 SHC4 SHC2 MAP2K1 SHC3 PDGFD MAP2K2 TGFA BCL2L11 ERBB3 PDGFC BCL2L1 EIF4E BCL2 EGF RAF1 AXL RPS6KB2 FGFR2 RPS6 RPS6KB1 PRKCB IL6R PRKCA PIK3R3 CCND1 GSK3B PIK3CD STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA IL6 RRAS BAD MTOR PIK3R2 PIK3R1 FOXO3A NF1 FGF2 PTEN JAK1 HRAS GRB2 SOS1 FGFR3 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGS2 PPARG PTGFR HEL-S-298 EHHADH HPGD PTGDR2 CYP4A22 AKR1B1 PLA2G5 PLA2G6 NR1C2 PTGS1 TBXA2R PTGDR PTGIR PTGIS PLA2G4B CYP4F2 CYP4A11 PTGR1 CYP4F12 ACOX1 PRXL2B ACOX3 PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IF2B1 TLR4 IL23R RORC RORA SMAD2 NOD2 IL2RG IL-21 TGFB1 HLA-DMA STAT1 STAT3 IL18RAP TBX21 STAT4 IL21R IL12RB1 IL10 JUN IFNGR1 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL2 IL4 IL6 IL5 TLR5 TNF IL12A IL18 IFNG IL23A IL17F MAF IL1A IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling PIK3CD MAPK8 TGFB1 STAT3 GAB2 VAV1 JUN SRC SHC1 CXCL8 IL5RA MAPK1 CSF2RB CRKL FYN MAPK3 INPP5D BAD ENPP3 PTPN11 CCR3 MAP2K1 LYN PIK3R2 SYK PTPN6 PIK3R1 IL3 IL3RA BCL2L1 BCL2 RAPGEF1 CD69 RAF1 YWHAQ CBL HEL-S-1 FOS JAK1 STAT5B HRAS GRB2 SOS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NFKB1 SP1 MAOA GPX1 HEL-S-44 MAPK14 HEL-75 CYBB GCLC MGST1 GSTT2 NFE2L2 TXN2 UGT1A3 XDH NQO1 GPX3 TXNRD2 NOX3 CYP1A1 NOX5 JUNB FOS NOX4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 FABP6 SLC10A2 ABCB11 ABCC2 SLC51A SLC51B ABCB1 ABCC3 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI LATS1 TEAD4 LATS2 HDAC3 NF1 HDAC1 SIN3A MERTK SKIL TEAD2 TEAD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ECHS1 ACSF3 ACAT1 PCCA PCCB DBT MLYCD BCAT2 MCCC1 IVD ACADSB BCAT1 DLD HSD17B10 ACAD8 MCCC2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development NOTCH1 EGFR SMAD4 MAPK9 FGFR2 FOXC2 FOXC1 MAP3K1 INHBB BMP4 JUN SHH SFRP1 DKFZp781O1323 PITX2 FGF10 DKK2 MAPK3 SMAD1 TGFA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 MAPK10 MAPK9 MAPK8 RPS6KA2 MAP3K1 JUN IFITM1 IFITM2 RPS6KA3 MAP2K3 MAPK1 MAP2K4 MAPK12 DDIT3 MAP2K6 MAPK3 MAPK13 BST2 ATF2 MAPK11 MAP2K1 MAPK14 IFI27 MAP2K2 MAP3K10 MAP3K11 EIF4E BCL2 RAF1 RPS6KA1 JUNB FOS FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway GSTM2 MTTP APOB ACACA MLXIPL ABCC2 FASN PPARGC1B SLC27A5 FOXA2 FOXO1 ABCC3 INS SLCO1B1 IRS1 FOXA1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B1 ABCC2 ABCG2 BCHE CYP3A4 CES2 UGT1A10 CES1 ABCC1 UGT1A1 UGT1A9 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 WNT3 LRP6 FZD3 WNT3A NEUROD1 CCND1 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 TICAM1 PARP1 TRADD FADD MAPK8 FTL CASP8 TNF RIPK3 TNFRSF1A CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2 SMAD4 RELA EP300 CHUK STAT3 RELB IGF1 CEBPB IKBKG IGF1R TNFRSF1A NFKB1 IL6 TNF RPTOR MAPK11 MTOR NFKBIA MLST8 FOXO3A AKT1S1 TWEAK IL6R MAP1LC3A TRIM63 TNFRSF12A NFKB2 IL1R1 IKBKB FBXO32 ACVR2A IL1B REL JAK1 GDF8 IL1A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment BDNF SHC1 PDPK1 EIF4EBP1 PTPN11 NFKBIA BCL2L11 EIF4E RPS6KB2 RPS6KB1 MAPK8 STAT3 BAX CASP8 RAPGEF1 FADD TRADD IKBKB RAC1 SMPD1 HRAS PAK1 NRAS MAP3K1 CTNNB1 MYC IRS1 MAP2K4 MAPK1 KRAS MAPK3 MAP3K5 MAPK11 MAP2K1 HEL2 MAP2K2 BCL2 RAF1 BMP7 LEF1 PRKCH PRKCB PRKCE PRKCA TCF7L2 TCF7L1 ARHGAP35 CFL2 PRKCI TIAM1 PARD3 MAPKAPK2 CYCS RTN4R IQGAP3 GSK3B HEL-S-15 NPTX2 PIK3CD MAP2K5 PRKCZ NGFR CASP9 EEF2 TP73 DOCK7 CHUK WASL APAF1 EEF2K TRAF6 CRK PLCG1 IKBKG ROCK1 ROCK2 JUN HEL-S-47e PARD6B PIK3CA PARD6A MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 LIMK1 ARHA BAD MTOR CDC42 FOXO3A YWHAQ HEL-S-1 YWHAG YWHAZ CREB1 FRS2 GRB2 SOS1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FGFR2 PIK3R3 MAPK10 MAPK9 MAPK8 FZD10 PTCH1 SMAD1 PIK3R4 PIK3R2 PIK3R1 SMO FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 SMAD4 RUNX2 STAT1 FGFR4 BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 WNT5B NOTCH2 NOTCH3 NOTCH1 PRKCH PRKCB PRKCE PRKCA WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PRKD1 BMP2 MYOD1 WNT2B PIK3CD PRKCZ WNT16 PIK3CA MAPK7 LRP5 LRP6 IHH RBPJ FGF7 FGF8 FGF9 SOX9 HES6 PRKDC PIK3R5 JAG2 FZD4 SMAD9 FGF18 FGFR1 PPARG PIK3C2G PIK3C2A GLI3 PIK3C2B HEY2 FGF2 WNT9B FGF7B WNT9A FGF7A WNT8A WNT8B DLL3 DLL4 HES3 MAPK6 HES2 MAPK4 FGF5C FGFR3 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling NLRP3 MMP9 IRF7 KLRD1 TGFB1 CCR2 VEGFA NFKB1 IL6 CSF1 CXCL8 TNF CCL2 PYCARD IL12A IFNG IL1B IL17F PTGER4 CXCL9 IFNA1 AHR PTGER2 CXCL1 IL17A AREG CCL3 IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP ASCL1 CXCL2 MBP MYT1 SOX8 SOX6 IGF1 SOX5 NKX2-2 BMP4 SHH NKX2-6 MOG LIF OMG OLIG1 OLIG2 SOX10 TNF SOX9 FGF2 IL1B BMP2 CXCL1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A FAN1 CREBBP CHRNA7 ARHGAP11B GOLGA8R CCL5 MTMR10 KLF13 OTUD7A FYN GPR75 GOLGA8O KAT2B GOLGA8Q TRPM1 FANCD2 GRM6 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKB1 MUC1 IL6 IKBKB CHUK RELA TNF NFKBIA IKBKG MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CCNG1 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER1 ADCY3 PTGER3 ALOX12 LTC4S PTGS2 GNAI1 ALOX5 ALOX15B ALOX15 ALOX5AP NRAS KRAS GNAS MAPK11 SIRT1 IGFBP5 PTGS1 CDKN1A RB1 PTGIS PTGER4 HRAS PTGER2 PRXL2B PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes ADCY1 HDAC2 EP300 EZH2 PRKAA2 SIRT1 AHR RORC MAPK10 RORA MAPK9 MAPK8 CSNK1D C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC HTR7 CSNK1E PROK2 HEL-S-80p AgRP PROK1 CHRNB2 UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CARTPT MTNR1A CLDN4 MTNR1B PSPC1 TIMELESS UTS2 SIK1 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM TNFRSF11A NPAS2 RAI1 AANAT UBC NKX2-1 DRD1 PTEN DRD2 DRD3 PPARGC1A DRD4 HDAC3 EGR1 SIN3A ZFHX3 OPN4 OPN3 HOMER1 NONO GFPT1 NR1D2 NR1D1 BTBD9 NR2F6 SETX STAR ID2 ID4 HNRNPD ID3 FBXL3 PML SLC9A3 TCF2 OGT ADA TPH2 TOP2A TPH1 KDM5A SUV39H2 CHRM1 SUV39H1 FAS BHLHE41 CDK4 NR1C1 HEBP1 RBM4 DBP JUND SIX3 HEL-S-2 KLF10 KCND2 SFTPC PAX4 MC3R SFPQ NCOR1 ADORA2A THRAP3 MTTP CRY2 KCNMA1 CRY1 AVP NLGN1 PRKAA1 PHLPP1 CIPC HDAC1 CRX RBM4B TYMS NPS PROX1 ATOH7 PROKR1 NFIL3 GNA11 NOCT RPS27A NTRK1 ARNT2 F7 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HS3ST2 HCRTR1 PER2 ATF5 PER1 PER3 ATF4 MYBBP1A GSK3B GHRH LEP KLF9 GHRL NGFR BMAL2 RELB BTRC ROCK2 SKP1 JUN IL6 DDC NOS2 PRKDC NAMPT PPARG TH CREB1 CRH GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other GPR17 P2RY11 HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 CCR2 OR2A5 LGR6 OR2A4 ADGRL2 GPR18 ADGRL3 OR7E24 ADORA2A GPR83 PTGFR CHRM2 CHRM3 OR1G1 OR2M4 GPR61 C5AR2 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 HTR7 EDNRA GPR176 GPR132 GNRHR CCR5 GPR135 UTS2R ADGRV1 ALG6 OR1F1 F2R OR2H1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 SMO GPR162 CCKBR OR5AC2 FSHR ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 ADRB2 IL8RB MCHR2 GHRHR DRD3 FY CXCR1 DRD4 CNR1 CXCR3 S1PR1 OR2B6 NTSR1 OR5D3 P2RY13 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p RB1 PRKAA1 HEL-S-133P HEL-S-30 HEL-S-162eP RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism HEL-S-53e CYP2A6 CYP1A1 ADH1A RPE65 DHRS4 CYP3A7 SDR16C5 CYP2W1 RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT BCO1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PLCB1 CRTC2 INSR PRKAA2 EIF4EBP1 RPTOR PRKAG1 PRKAG2 SLC2A4 ADRA1B ACACA ELAVL1 ADRA1A FASN RPS6KB2 PRKAG3 PPARGC1B NR2A1 PRKAA1 GYS2 GYS1 LIPE PRKACG LEPR PRKAB2 STRADA RPS6KB1 STRADB CPT1C PRKAB1 CCNA2 CAB39 PIK3R3 ADIPOR1 ACACB ADIPOR2 CAMKK1 CCNB1 CAMKK2 INS-IGF2 SLC2A4RG STK11 LEP PIK3CD TSC2 EEF2 TSC1 EEF2K HMGCR PIK3CA CPT1A MTOR PIK3R2 PIK3R1 CDKN1A IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG STAT1 STAT3 CISH GAB2 SHC1 IL2 SOCS3 MAPK1 CRKL FYN MAPK3 PTPN11 MAP2K1 MAP2K2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 CBL RPS6KB1 JAK1 STAT5B PTK2B HRAS JAK3 NMI GRB2 LCK IL2RA SOS1 IL2RB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL15 F2RL1 IL2 ITGB7 EGFR DHODH IFNG IL-21 TNF NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF2S1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway STAR RUNX2 CXCL2 FOXO1 DKFZp781O1323 PDPK1 SLC1A2 EIF4EBP1 MAPK1 TNF MAPK3 PTPN11 MAP2K1 MAPK14 MAP2K2 SLC2A4 EIF4B DYNLT1 BMP7 NFE2L2 DYNLT3 PRKAA1 RPS6 RPS6KB1 PRKCB GNA11 PRKCE PRKCA HIF1A CAMKK2 HCRTR2 HCRTR1 PRKD1 LEP GHRL CASP9 PRKCZ MAPK9 MAPK8 CASP3 GNAI1 STAT3 IL10 MAPK7 IL4 NPFFR1 IL6 DAGLA CXCL8 FSHB SGK1 LHB BGLAP NPY SMAD1 GNAS NPVF VHL MTOR CGA PIK3R2 HCRT PIK3R1 OPRK1 GCG CCK POMC GH1 IL9 GNRH1 ARRB2 TH RPS6KA1 BMPR1A NOX4 CREB1 IL1B MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP16 MMP9 PRKD3 MMP15 MMP23B PRKCZ SCN8A MMP17 MMP19 BDNF NOS2 SNAP25 AGER SLC2A3 PRKCH MMP21 MMP20 PRKCB MMP25 MMP24 PRKCE MMP27 SCN9A HEL-S-62p PRKCA MMP28 MMP7 TRPA1 MMP2 MMP3 SORD TRPV1 PRKCI MMP10 PRKCQ MMP12 MMP11 SCN10A MMP14 CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR TXN AMD1 APIP MAT1A SMS MRI1 IL4I1 MSRA MTAP ADI1 CHDH MSRB2 MSRB3 ENOPH1 SRM HEL-S-61p HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA TFAP2A ARHGAP29 ARHGEF2 IRF6 TP63 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KDR PDGFRA PDPK1 HGF PRKAA2 MET RPTOR MLST8 PDGFC SLC2A4 EIF4E EIF4B EGF ELAVL1 RPS6KB2 FGFR2 GYS2 GYS1 RPS6 LIPE STRADA RPS6KB1 RHEB AKT1S1 CAB39 HIF1A JAK3 STK11 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 ULK1 PIK3R4 PIK3R2 PIK3R1 IL3RA MDM2 SLC2A3 PTEN IKBKB JAK1 HRAS EGFR FGFR4 NRAS VEGFA FGF10 CSF1 IRS1 IRS4 MAP2K1 MAP2K2 FOXA1 HEL-S-125m TCL1B TCL1A ACACA PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 PELO CDC37 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 HIF3A GNGT2 FGF8A RAB8A OSMR COL2A1 KIT PHLPP2 COL11A2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD RAB11B NGFR COL3A1 CASP9 KITLG GHB3 CSF3 CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 PFKFB2 PFKFB1 CSF1R PFKFB4 EFNA5 EFNA4 CHAD FGF20 NOS2 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 FGF16 EFNA3 FGF14 EFNA2 PIK3R5 COL5A3 COL5A2 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 ITGB4 PIK3C2A FLT4 LAMC2 PIK3C2B ITGAE FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C ANGPT4 ANGPT2 ITGB1 LAMB3 ANGPT1 PRL LAMB2 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PRLR PPP2R2B PPP2R2D EIF4EBP1 GHR CDKN1B ITGB3 ITGA2B LAMC1 IBSP IL6R ITGA2 COMP COL1A1 LAMA5 THBS1 VTN SPP1 LAMB1 SLC2A2 PPARGC1A CRTC2 TNC FLT1 INSR PDGFA IGF1 FOXO1 IGF1R INS CHRM1 AKT3 MAPK1 KRAS MAPK3 ATF2 COL1A2 PDGFD PRKAA1 PHLPP1 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 F2R GNB3 ITGAM GNGT1 CREB3L2 ITGAX CREB3 CREB1 ATF6B INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 AKT3 SNCA APP STAT1 CEBPB SRPK2 BACE1 SET BDNF TARDBP MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 BRAF JUN ALK KSR1 SHC1 FOS GAREM2 MYC KRAS SOS2 MAPK3 MAP2K1 MAP2K2 SOS1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR CREBBP HDAC2 RELA EP300 NFATC1 NFKB1 HDAC5 SUPT4H1 HDAC8 SP1 HDAC9 HDAC7 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 NFKBIA CDK9 PPP3R1 PPP3R2 HDAC1 NELFB NELFCD NELFA PPP3CA HDAC3 PPP3CC TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 TDO2 NMNAT1 IDO1 NMRK2 NMRK1 NAPRT NAMPT AADAT HEL-S-90n HAAO KMO KYNU NMNAT3 AFMID NMNAT2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RPS6KA2 SHC1 PDPK1 SOCS3 SOCS1 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 PTPN11 SHC3 SLC2A4 EIF4E RPS6KB2 INPPL1 CBLC RPS6KA4 GYS2 RPS6KA6 GYS1 LIPE RPS6KA5 GRB14 GRB10 ENPP1 MAP3K8 RPS6KB1 MAP3K6 RHEB GYG1 MAP3K7 INPP4A TRIB3 STXBP3 PIK3R3 STXBP4 RRAD PPP1R3A KIF3A STX4A RAB4A EHD1 EHD2 MAP3K12 ARF1 HEL-S-31 SNAP23 PTPRF FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 TBC1D4 SGK2 ARF6 SNX26 MAP4K3 MAP3K2 HEL-S-42 PFKL MYO1C PFKM SGK1 PIK3R4 PIK3R2 PIK3R1 RAPGEF1 XBP1 MAP3K13 GSK3A PTEN IKBKB RAC1 EGR1 HRAS INSR MAP3K1 FOXO1 IGF1R RPS6KA3 IRS1 MAP2K3 IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 HEL-S-61 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 PRKAA1 PRKCH PRKCB PRKCA PRKCI PRKCQ GSK3B PIK3CD MAP2K5 PRKCZ CRK JUN PIK3CA MAPK7 SH2B2 MAP3K14 MTOR SNAP25 STXBP1 FOXO3A PIK3C2G PIK3C2A CBL RPS6KA1 FOS MAPK6 MAPK4 GRB2 SOS1 VAMP2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 TSC2 TSC1 EEF2K NRAS BRAF GAB2 PLCG1 BDNF GRIN1 SHC1 TRPC6 TRPC3 ARC NTRK2 DLG4 EIF4EBP1 MAPK1 KRAS MAP2K1 MTOR RPS6KA1 RPS6KB1 RHEB CREB1 HRAS GRB2 HOMER1 SOS1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades TFPI APOA2 C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 NR1C1 SP1 GPAM STAT3 CYP1A2 CYP1B1 NR0B2 ACOX1 CYP1A1 JUN PCK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2A CAMK2G GRIN1 ARC MAPK1 MAPK3 RYR2 NLGN1 NLGN3 CYFIP1 NLGN2 YWHAG NRXN1 FMR1 NRXN3 NRXN2 GRIN2B RPH3A SYNGAP1 DLGAP1 TJP1 DLG2 SHANK1 CAMK2D HOMER1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 NFKB1 IL18 IL6 MAVS IL1B CSF2 TNF CGAS RIGI CXCL9 MITA CCL2 IFIH1 CXCL11 IRF3 TLR8 TLR7 TLR3 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT1A8 UGT2B7 ABCC2 UGT1A3 UGT1A10 UGT1A1 ABCB1 UGT1A9 ABCC3 SLCO1B1 CYP3A4 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling GSK3B TRAF3IP2 IL17RC IL17RB RELA STAT3 IL17RA TRAF3 TRAF6 CEBPB IKBKG CEBPD PIK3CA NFKB1 SP1 MAPK1 MAP3K14 MAPK3 NFKBIB IL25 MAP3K7 IKBKB IL17F IL17D JAK1 IL17C IL17B IL17A ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 UGT1A3 NQO1 CYP1A2 GSTM1 CYP1B1 UGT1A1 SULT1A1 STS UGT1A9 SULT1E1 CYP1A1 ARSL CYP3A4 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTX1 SPRYD4 CDKN2A AP3D1 TRMT1 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 TRIP13 LAMTOR3 LAMTOR5 LY6K PLXND1 TUSC2 GEMIN2 LTN1 CPOX ARID4B CALCOCO2 MSI2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 VPS39 KPNA3 EIF4E FADS1 AXL MYLIP ATG3 TNLG5A TPM3 TPM1 STX7 GYS1 UBE4A ATG9A CDKAL1 RAB30 GPD2 TMEM59 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 RAB5C CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP NPRC GAS2L1 SAC3D1 MCL1 CCND1 MPDU1 CD164 VCAM1 BRPF3 HMGA1 SLC4A10 TNFRSF10A NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 BCL6 TRPV6 UBE2S CHMP2A SRPRB MENT DKFZp761E1322 PICALM SLC25A1 DOCK5 ADPGK TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 PTBP1 SMAD1 DNMT3B TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 PPP3R1 UTP15 HSDL1 RBM19 SIGMAR1 ARID1A TXN2 NT5C3A RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 UNC93B1 NXN UHRF1 PLAG1 HSD17B12 MRM1 AURKB GNA13 DNAJB1 CAND1 PPP3CA POLR2C RAB23 TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT ABCF2 SLC25A22 PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 IRS1 MAPK12 MAPK14 TCL1A PPIF MTRR LPL RTN4 KIT PRKCI IQGAP3 DOCK7 RARS1 COL4A2 HEL-S-26 HEL-S-47e MAPK7 CDK6 E2F3 LAMC2 FGF2 P4HA2 NELFCD CDKN1A PPP2R5C PPIB BDNF CDKN1B MAP3K8 LAMC1 SMC1A C1QBP SUCLG2 TNFRSF10B ITGA2 SNAP23 PTPRF CAP1 ATAT1 SYPL1 TUBA1A FBXW11 GPAM DDX5 CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 ATP6V1F GFPT1 ATP6V0E1 CPNE8 VEZT SERPINE2 TMEM41B EHMT1 CLDN1 PWP1 ABCG2 DCAF7 RRP8 PNP DHX57 KRAS LOC541469 CHORDC1 RAVER2 MYB CIAO2A SEC62 GOLGA7 NOTCH2 CDK5RAP3 HOXA5 NOTCH1 BCL2 ARL10 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 OTULINL POM121 HACD3 MRPL20 BACH1 FXR2 COMMD9 TERT RDH10 GRPEL2 CEP72 KCNN4 VTI1B SNX6 SLC38A1 GSTM4 PHC2 HARS1 RAB27B BRI3BP PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B FERMT2 HOXD8 RNP24 RCOR1 CDKN1C NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MEOX2 MRC2 PANX1 COIL CHAF1A SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC ANXA2 MRPS24 ELOVL5 ATP2A2 ELMOD2 AP2A1 TMT1A AP3B1 PRPF40A RHOB SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN PTRH1 VAMP3 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG HEL-S-66 PTPA PURA NT5E PGRMC1 PPP1R7 USP1 SHOC2 TAF9B SRSF10 MPZL1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation TLR4 IL10 CCL11 TMPRSS2 IL12A FURIN IL2 HMGB1 IL4 IL18 IL6 GFAP IFNG CXCL8 IL1B MAPK1 TNF IFNA2 ACE2 TLR8 TLR7 IL1A TLR3 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling GSK3B IL7R IL2RG STAT1 STAT3 IL7 MAPK1 STAT5B FYN MAPK3 JAK1 BAD PTK2B JAK3 MAP2K1 MAP2K2 PIK3R2 PIK3R1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 KLKB1 BDKRB1 SERPING1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development ID2 ASCL1 ID4 MBP MYT1 SOX8 SOX6 NFIA SOX5 NKX2-2 EGR2 BMP4 SHH NKX2-6 PDGFRA OLIG1 OLIG2 SOX10 MYRF CHD8 PTN ZNF24 SMAD1 NFATC2 DUSP15 SOX2 NKX6-1 SOX9 ZNF488 LGI1 OPALIN SOX11 ZBTB33 ZEB2 BMP1 TMEM98 CNTN1 CSPG4 WNT10A FGF2 HES5 TCF7L2 PRKCA RELN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 MTOR FOXO1 IGF1R NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC18A2 DDC MAOA SLC6A3 PNMT TH TPH2 DBH TPH1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 ALPL HEL-S-302 PLPBP ALPI HEL-S-1a PIGV DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CSNK1A1 FOXO1 CDK4 DCAF7 RPTOR DEPTOR MLST8 CRY2 NOTCH1 CDKN1B SIRT1 PSEN1 LIN54 NEUROG2 GMNN HES1 DNER AKT1S1 LIN52 RBL2 HES5 RBL1 TFDP1 TFDP3 AMPH LIN37 LIN9 RBBP4 E2F5 EIF2B5 REST CCND1 TFAP4 SPRY2 GSK3B CASP9 TSC2 APP CASP3 TSC1 NFATC1 E2F4 MTOR DYRK1A TFDP2 CDK6 FGF2 CREB1 H3F3B LATS2 PSENEN BACE1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK1 IRAK2 IRAK4 MAPK10 IRF7 SAFB MAPK9 TAB3 MAPK8 MYD88 RELA CHUK MBP TRAF6 MAP3K1 MAP3K7IP1 NFKB1 MYC MAP2K3 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB EIF4E RPS6KA5 MAP3K8 MAP3K7 FOS IL1R1 IKBKB MAPKAPK2 TANK IL1A GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 EGFR OTUD5 DGIC AHCTF1 LBR DSCC1 CHTF18 MTDH CHTF8 BRIX1 TOP2A RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 MYC RNF144B LMNB2 UBE2T SNURF S100A6 CD48 CEBPZ COL9A1 COL9A3 RAD17 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 ITGB1 SMAD2 HEL113 FLT1 RELA CXCL2 CDH2 VEGFA SNAI2 IGF1R DKFZp781O1323 SRC KDR SHC1 PDGFRA CTNNB1 CLDN1 PDPK1 SOCS3 RPS6KA3 SOCS1 PRKAA2 MAPK1 TNF MAPK3 CCL2 MAP2K1 MAPK14 MAP2K2 ACACA ZEB2 RAF1 RPS6KA4 SP7 RPS6 RPS6KA5 RPS6KB1 PRKCB IBSP HEL-S-133P HEL-S-102 GSK3B ACTA2 MAPK9 MAPK8 TGFB1 CSF3 PLCG1 IL10 COL4A1 JUN NFKB1 IL6 CXCL8 CRKL CPT1A BGLAP SIX1 SMAD1 CXCL5 HK2 MTOR DUSP4 CLDN5 SLPI PIK3R1 PCNA MST1R SMAD6 KLK15 PARP1 SMAD9 FZD1 FGFR1 WNT10B NR0B2 RPS6KA1 FOS PTEN IFNB1 TJP1 IL1B PPARGC1A CSF2 EGR1 GRB2 CXCL1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders HIST1H2BE TERF2IP TPP1 H2BC21 H2AC19 H2AX H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 ACD H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 TINF2 H2BC1 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H3-4 H2BC15 H2AC20 H2BC11 POT1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP FPGS UPP2 TDG TK1 RRM1 RRM2 ABCC5 GGH SMUG1 DHFR UCK2 UCK1 ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 XRCC3 CYP2A6 CES2 CES1 TYMS ABCC3 DPYD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination SOX8 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 WNT4 SRY RSPO1 AMH FGF9 SOX9 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway MAPK8 PAK1 CHUK STAT1 STAT3 WASL PDGFA MAP3K1 PLCG1 VAV1 VAV2 JUN SRC SHC1 NFKB1 MAPK1 MAP2K4 ARHA MAPK3 PTPN11 MAP2K1 NFKBIA COX2 PIK3R1 CDC42 RAF1 FOS RAC1 JAK1 HRAS TIAM1 GRB2 SOS1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease NOTCH3 HEL25 MEF2C HP1BP3 HSPB3 HSPB2-C11orf52 tmp_locus_29 LBR H2AZ1 LMNA ACTA1 MYOD1 MYOG DMPK AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 GLUD1 HAL GPT2 FTCD MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids PIK3CA CERS1 NFKB1 HIF1A ASAH2 TSC1 S1PR3 S1PR1 MTOR CERK SPHK2 IGF1R TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 MEF2C MEF2B CDKN2A CCND2 STAT3 BCL6 ID3 EZH2 IL21R NFKB1 MYC IL6 TLR5 TNFRSF13C BCR LYN TLR9 SYK TLR7 BCL2L1 ICOSLG CDKN1B CD40 SPI1 CD79B SPIB CCND3 CD79A POU2F2 TLR1 IRF4 POU2AF1 IRF8 TCF4 TLR10 TCF3 CDKN1A TLR8 TLR3 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD MAPK8 PAK1 STAT3 STRN ARAF NRAS BRAF CRK PLCG1 JUN ALK SRC PIK3CA RAP1A HGF AKT3 MAPK1 KRAS SOS2 CRKL MAPK3 MET BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 PIK3R1 CDC42 RAPGEF1 RAF1 CBL PIK3R3 CDKN1A PRCC RPL11 ELOA PAK6 RAC1 INSL3 PAK4 HRAS C8orf34 JAK3 GRB2 SOS1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R11 PPP1R10 PPP1R2 PPP1R8 PPP1R16B MAPK8 MBTPS1 PPP1R14A PPP1R14B PPP1R14C PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B HEL-S-89n PPP1R3E PPP1R1C PPP1CC PPP1R1B PPP1R3D PPP1R12B HEL-S-80p PPP1R14D PPP1R12C MBTPS2 DDIT3 PPP1R9A ERN1 BCL2 XBP1 EIF2AK2 MAP1LC3A PPP1R3A PPP1R7 EIF2AK1 EIF2S1 PPP1R15A PPP1R15B PPP1R13B ATF4 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOB LDLR APOE APOC2 LPL APOC3 APOA2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway FASN RXRA CYP3A4 NR1H3 CYP2B6 ABCG8 ABCG5 SCD CYP7A1 IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling IL9 IL2RG STAT1 STAT3 MAPK1 STAT5B MAPK3 JAK1 JAK3 MAP2K1 GRB2 MAP2K2 CDK9 IL9R PIK3R2 PIK3R1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway CDKN2A KLF4 CEBPA TREM1 CYP3A4 NFATC2 SLC2A4 ADRA1B CDKN1B TPM1 CD40 CDKAL1 IL25 IRF4 IRF8 IL12A NR1C2 HIF1A CCND1 TRAK1 TGFB1 ALOX5 BCL6 TRPV6 THBD BDKRB1 BGLAP SPP1 CYP7A1 GADD45A STEAP4 LPGAT1 CCNC GXYLT2 PRDM1 KNG1 CLDN2 SALL4 TNFSF11 LGALS9 EPHB4 SULT2A1 KRT71 SLC34A2 CCNE1 S100A2 ABCB1 MED9 CYP1A1 LCE1F LCE1D LCE2B CDC34 NINJ1 S100A4 S100A9 S100A8 TNLG2B COL13A1 CLEC16A KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 FGF23 HLA-DQA2 HLA-DQA1 KL SLC37A2 KRTAP12-2 KRTAP8-1 BMP6 CYP2S1 ID4 TRPV5 PNOC ID1 CLPTM1L STS MXD1 ALPG ZNF257 FOXO1 SPRR1B SFRP1 CD200 HLA-DRB1 ORM1 HILPDA TNFAIP3 MYC CYP27B1 ORM2 ADAMTS5 CDK2 SULT1C2 RXRA CASP14 DUSP10 NR1i1 ADGRE5 CASP5 DACT2 TIMP3 ATP2B1 CTLA4 SOSTDC1 KRTAP5-1 CA9 ABCD1 SLC8A1 CAMP HNF1A KRTAP5-4 KRT34 CEACAM1 CYP2C9 KRT38 DEFB4B CYP2B6 COLEC11 SATB1 TNFRSF11B PTH ALPI HEL57 IGFBP1 SEMA3B ASAP2 IGFBP5 CST6 PTHLH DNER IL1RL1 JUNB CST1 CLMN CREG2 HSD17B2 CDKN2D LRRC25 S100G KRTAP10-2 CDKN2B KRTAP10-4 PRKCQ CDKN2C CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CYP24A1 KRT16 CD9 CBS LRP5 EFNA5 S100A6 ITGAM ADRB2 CDKN1A PTGER4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins PLCB4 TERF2IP PRKCZ MAPK9 CADM1 CSN3 GRIK2 GPHN CDH2 RAP1GAP CHL1 EPB41L3 NCDN CAMK2G MAP4 NEO1 CLASP1 GRIN1 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 EFNA5 GABRG2 SNW1 DAB1 AGRN ATP2B1 KCNQ2 KCNMA1 CASK STX2 GRIN2B MAPK4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PPARGC1A SIRT1 IGF1 PRKAB2 MTOR EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling MEF2C CAMK2A RPS6KA2 MEF2D GAB2 VAV1 NEDD4 VAV2 SRC SHC1 PDPK1 ERBB2 EIF4EBP1 SOS2 PTPN11 COX2 EGF INPPL1 CBLC RPS6KA5 GRB10 RPS6KB1 STAT5B PTK2B MAP4K1 MAPK9 MAPK8 STAT3 ARF6 MAP3K2 RAP1A CRKL INPP5D PIK3R2 PIK3R1 PTEN RAC1 JAK1 HRAS RALA EGFR PAK1 STAT1 BRAF MAP3K1 FOXO1 RPS6KA3 JUND MAPK1 KRAS ATF1 MAP2K1 MAPK14 MAP2K2 RAB5A RAF1 GJA1 PRKCB PRKCA PRKCI SPRY2 HEL-S-15 MAP2K5 PRKCZ CRK PLCG1 ROCK1 JUN MAPK7 CAV2 SP1 USP6NL SH3GL3 ERRFI1 MTOR NDUFA13 PLCE1 SH3GL2 STXBP1 RALBP1 PCNA CDC42 HGS STAMBP RIN1 STAM2 SH2D2A AP2A1 IQGAP1 FOXO4 PLD2 ATXN2 TNK2 PIK3C2B PTK6 CBL SYNJ1 AP2S1 RPS6KA1 HEL-S-34 PXDN NCK2 NCK1 VAV3 EPS15L1 FOS EPN1 AP2M1 PLSCR1 ARHGEF1 RALB CREB1 ASAP1 NEDD8 MAPK4 REPS2 RICTOR CSK LIMK2 GRB2 ITCH FOSB SOS1 PTPN5 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 CALM1 PDE3B RYR2 ADCY3 ADRA1B MYLK ADCY1 ADORA2B ADCY8 ADRA1A PDE4A ADCY6 PDE3A RYR3 ADRA1D PDE4B PDE4D HEL-S-80p PPP1R12C ADCY9 ADORA2A NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation ITGB1 HDAC2 HDAC10 HDAC11 DMBX1 ASCL1 CDH6 MPZ CDH2 ZIC1 MBP HOXA1 ID1 FOXD3 SNAI1 SOX5 MSX2 SNAI2 MIA BMP4 OLIG3 PAX3 ISL1 DCT OLIG1 PAX7 CTNNB1 OLIG2 HAND1 HDAC5 MYC SOX10 HOXB1 CTBP2 HDAC8 GFAP DLX5 HDAC9 TWIST1 HDAC7 HDAC6 PRTG GBX2 MSX1 TFAP2A MYB TFAP2B ZIC5 TBX6 NOTCH2 PHOX2B NOTCH3 GJB1 NOTCH1 TLX2 LHX1 PMP22 BMP7 LHX5 NEUROG1 FGFR2 HDAC1 HES1 TCF4 DVL1 HES5 FGF8A DVL2 DVL3 TCF7L1 NFKB2 COL2A1 WNT1 COL11A2 WNT3A GSK3B AXIN1 AXIN2 NFKB1 RBPJ SMAD1 FGF8 SOX9 FGFR1 RHOB FZD3 HEY2 FGF2 WNT8A DLL3 DLL4 HDAC3 FGFR3 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN1 GRIN2B DLG4 NLGN1 GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 NLGN3 NLGN2 NRXN1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCB4 PLCH1 PLCH2 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 PIP4K2A PLCG2 PLCG1 PIK3CA MTMR10 INPP5D PIK3R4 PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 IL2 SPN CD27 CD3G CD3E CD3D CD80 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 RAD9A CDKN2A CASP9 CASP3 BAK1 TP73 APAF1 BAX YAP1 MRE11A MDC1 TRAF6 RIF1 SMC3 KAT5 TRIM28 HSF1 RAD50 TP53BP1 RAD51 BLM ACTL6A RASSF1 NABP2 MCPH1 ATF2 FANCD2 PCNA PRKDC PARP1 H2AX MDM2 ATM NBN ATR SMC1A RNF8 BRCA1 TERF2 LATS1 BRCA2 RAD52 CDK5 CHEK2 RAD17 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production HMGCR FDFT1 PDIA2 DGAT1 APOA5 SQLE APOC2 APOC3 SOAT1 ABCG8 APOC1 ABCG5 CYP7A1 LIPC APOA2 ACSS1 APOA4 SCARB1 MTTP APOB LDLR PLTP APOE LPL ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EP300 ACKR3 HGF CYP2C19 CYP3A7 NRG1 CYP3A4 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 AHR CYP4F12 ACOX1 CCND1 IL2 APOA5 GCC1 TNS4 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 MGST1 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 ABCB4 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 CYP1A1 SLC19A2 SLC2A3 GSTM3 PLK2 ABCC3 SMARCA1 SLCO1B1 HEL-S-128m SLC6A5 SLC6A7 ABCB11 SLC6A8 SLC6A9 DNAJB1 CPEB4 GSTM5 SLC6A1 SLC6A2 EPB41L4B ENC1 ANKRD1 TGFBR2 NCOA1 SLC2A14 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 EGFR SLC2A10 TSC22D3 SLC2A13 PTGS2 SLC2A12 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 BAAT POU5F1 SLC7A5 B3GNT5 CDC42EP3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF NR1I3 FGD4 TNF SRPX2 GPR153 SERTAD2 CAP2 CCL20 CAVIN2 PTGES3 GSTM2 NR1i2 NR1H4 CYP8B1 KTN1 FASN FABP1 GSTA5 GSTA4 SLC27A5 GSTA3 SLC6A3 SLC27A1 CDC37 NR3C1 SLC39A9 UGT1A1 EPHA2 SLCO2B1 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 DNER SLC39A3 AIP ALDH3A1 FGF8A SCNN1A FKBP5 NFKB2 SLC26A2 ABHD2 IP6K3 DNAJC15 SLC2A9 ALAS1 SRXN1 SLC2A6 SLC2A7 SLC2A8 ARL5B CPT2 ZIC2 ME1 PDK4 POLK ACADM SRGN GPX2 HEL-S-25 HEL-S-22 TGFBR3 DNAJC7 NAV3 ADGRF4 BIRC2 BIRC3 SLC5A12 SLC5A10 PRRG4 UGT1A4 STOM UGT1A7 TXNRD3 S100P SPRY1 ADH7 PCK1 KLK15 FGF13 HSP90AB1 ABCC5 SRC DBI CCL2 APOA2 PLTP CDKN1B IL12B SMC1A IL12A IFNG GADD45B CDC2 IL17B TGFB1 STAT3 PPP1R14C BAX ALOX5AP TXN SERPINA1 THBD APOC3 CPT1A ABCG8 ABCG5 SCD CYP7A1 GPAM SULT2A1 CYP1A2 CYP1B1 NR0B2 ABCB1 BHLHB2 SLC2A2 SLC5A1 SLC5A2 SLC6A20 SLC5A5 PPARGC1A EGR1 UGT2B4 SLC6A19 UGT2B7 ABCC2 SLC6A18 GSTM1 SULT1A1 SNAI2 SLC5A8 FOXO1 CDK4 TNFAIP3 NR1C1 MYC IL11 RXRA JUND NR1i1 HEL-75 GCLC NFE2L2 CYP2C9 RGS2 CYP2A6 CYP2B6 EHHADH IGFBP1 HES1 JUNB SLC7A11 FTH1 NR1H3 SLC39A8 GSTM4 KAT2B KEAP1 MAFG SLC39A14 FTL CDKN1C JUN HMOX1 SP1 MAFF GCLM PDE4B AMIGO2 PTPA IL1B NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling GSK3B HDAC2 EP300 STAT3 SKP1 SRC NFKB1 MAML2 SNW1 MAML1 FHL1 DTX1 RBPJ MAGEA1 CIRSR MTOR SPEN PIK3R2 SAP30 NCOR1 NOTCH2 PIK3R1 HES6 NCOR2 NOTCH3 NUMB NOTCH1 APH1B FBXW7 ADAM17 MAML3 JAG2 PSEN2 HDAC1 PSEN1 HEY2 HES1 DLL3 HES5 DLL4 PSENEN ITCH LCK DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MARCHF5 DNAJC19 TIMM8A TIMMDC1 USP9X STAT2 PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 C1QBP AIFM1 MCL1 TRAK1 MFN2 PARK2 VCP UFD1L MIPEP UBXN1 CLPB TXN2 PLEK FLJ10842 MICOS13 OPA1 OPA3 GDAP1L1 TXNRD2 LONP1 SACS PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CDKN2A RELA ZAP70 IRF2BPL GRAP2 HLA-DRB1 TYK2 LTA PDPK1 LCP2 CARD11 BCL10 CCL19 MAPK1 PTPRC TNF HLA-DRA FYN MAPK3 CCL28 LAT RPTOR IL18R1 MAP2K1 NFKBIA DEPTOR CTLA4 MAP2K2 MLST8 BCL2L1 RAF1 CD80 RHEB IL12B IL12A IFNG IL23A PRKCQ CCND1 LCK IL17A GSK3B IL23R PIK3CD TSC2 MYD88 CD3G CD3E CHUK TSC1 CD3D BAX STAT4 IFNAR2 IKBKG PLCG1 IL12RB1 JUN NFATC1 IFNAR1 NFKB1 IL2 IL4 MTOR PIK3R1 ICOS FOXO3A FOS CDKN1A PTEN IFNB1 IKBKB PPP3CC RICTOR HRAS GRB2 SOS1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG2 PRKAG3 PRKAA1 RHOB YAP1 RHO HMGCR CTGF PRKAB2 PRKAB1 LATS1 TEAD4 CYR61 PRKAA2 LATS2 ARHA STK4 TEAD2 RHOD TEAD3 MOB1A PRKAG1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 ACE2 AGTR1 AVPR1B ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer EGFR BAK1 NRAS BRAF CTNNB1 PDPK1 MYC AKT3 ERBB2 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 HEL-S-28 CTNNA1 CTNNA3 EGF RAF1 CTNNA2 FGFR2 LEF1 DDB2 PIK3R3 TCF7L2 TCF7L1 GADD45B GADD45G CCND1 GSK3B PIK3CD POLK CASP9 ARAF BAX AXIN1 AXIN2 PIK3CA BAD GADD45A APC PIK3R2 PIK3R1 FGFR1 FOXO3A FGF2 FOS CDKN1A PTEN HRAS APC2 GRB2 SOS1 FGFR3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 STAT2 MYD88 CHUK STAT1 TRAF3 TRAF6 TBK1 IFNAR2 IKBKG JUN TYK2 NFKB1 IFNAR1 MAVS RIGI MAPK14 NFKBIA TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 RIPK1 MAP3K7 FOS TICAM1 IKBKB JAK1 IFIH1 IRF3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDKN2A EGFR SMAD2 SMAD4 PAK1 BAK1 RELA STAT1 BRAF VEGFA TGFBR1 RAD51 CDK4 AKT3 ERBB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 TGFA BCL2L1 EGF RAF1 RPS6KB2 dik RAC3 E2F2 RPS6KB1 DDB2 PIK3R3 RB1 PAK6 PAK4 GADD45B TIAM1 GADD45G CCND1 PIK3CD MAPK10 POLK CASP9 MAPK9 MAPK8 TGFB1 CHUK STAT3 ARAF BAX IKBKG PIK3CA NFKB1 ARHA BAD MTOR GADD45A PIK3R2 PIK3R1 RALBP1 CDC42 CDK6 E2F3 HEL-S-34 CDKN1A RALB BRCA2 IKBKB RAC1 JAK1 TGFBR2 RALA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 IDO1 GOT2 IFNA6 KYAT3 KYAT1 IL6 DDC IFNB1 IFNG AADAT IL1B HAAO TNF KMO KYNU AFMID IDO2 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development MEF2C NKX2-5 SMAD4 FOXC2 FOXC1 VEGFA BMP4 SHH NFATC1 ISL1 PITX2 CTNNB1 FGF10 HAND1 GATA4 MAPK1 NFATC3 SMAD1 NFATC2 PTPN11 FGF8 NFATC4 ERBB3 NOTCH1 FOXA2 HEY2 BHLHB2 BMPR1A BMP10 GATA6 BMPR2 TBX20 SMYD1 TBX1 FOXH1 IRX4 TBX5 TBX2 HAND2 BMP2 VEGFB VEGFC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 LAMB3 LAMB2 PTGS2 BAK1 RELA TRAF3 CDK4 MYC AKT3 RXRA CDK2 NFKBIA NFKBIB BCL2L1 BCL2 CDKN1B ITGA2B E2F2 LAMC1 DDB2 CCNE2 PIK3R3 RB1 CKS1B CDKN2B GADD45B ITGA2 TRAF1 TRAF4 COL4A3 GADD45G CCND1 TRAF5 CKS2 CYCS RARB COL4A5 BIRC7 PIK3CD FHIT POLK RXRB CASP9 LAMA5 RXRG LAMB4 CASP3 CHUK APAF1 BAX TRAF2 TRAF6 IKBKG COL4A2 BIRC2 CDKN1C COL4A1 BIRC3 SKP1 COL4A4 PIK3CA COL4A6 NFKB1 MAX CASP8 NOS2 GADD45A PIK3R2 PIK3R1 LAMB1 CDK6 E2F3 LAMC2 CCNE1 ITGAV CDKN1A PTEN IKBKB ITGA6 LAMA1 LAMA4 LAMA3 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MMP9 MEF2D EZH2 SHC1 TWIST1 SOS2 PIK3R3 HIF1A COL4A3 COL4A5 MAPK8 SPARC TGFB1 TUSC3 HEL-S-79 FOXQ1 FZD10 CDKL2 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 JUP PALS1 VTN NRP2 PKD1 CLDN22 CLDN20 CLDN24 CLDN23 EED CLDN11 CLDN10 CLDN15 PIK3R2 CTDSP1 PIK3R1 CLDN14 CLDN19 STRAP CLDN4 CLDN18 CLDN2 CLDN17 CLDN16 TMPRSS4 FZD1 NR2C2 WNT10B SUZ12 WNT10A GDF15 FZD3 NUBPL CRB3 FZD2 FZD5 FZD7 FZD9 FZD8 TJP1 MMP2 LATS2 HRAS TGFBR2 MMP15 SMAD2 SMAD4 PAK1 ID2 CDH2 FOXC2 ID1 SNAI1 FMNL2 SNAI2 FOXM1 TGFBR1 WNT7B WNT7A CTNNB1 CLDN1 AKT3 MAP2K3 MAP2K4 MAPK1 MAPK12 KRAS MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 RAF1 ZEB2 PROX1 WNT1 WNT3 WNT4 RBBP4 WNT3A GSK3B WNT2B PIK3CD TRAF6 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA LRP5 CLDN6 LRP6 RBPJ CLDN5 JAG2 FZD4 WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 GRB2 SOS1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 CYB TTC19 UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MAP1B BIRC5 TUBA2 MYH9 ERG EGFR SMAD2 STUB1 MAPRE1 AURKA HEL113 CFTR HDAC11 ITIH4 EP300 NEDD9 HTT KALRN ATXN3 ADRBK1 EP400 CCDC141 SHH POU5F1 FUS BDNF MIIP TARDBP ARID3A ISG15 BBIP1 CTNNB1 GARS1 CNOT6 HEL-S-2a HDAC9 TWIST1 MAPK1 HDAC6 MAPK3 MAP3K5 HEL-S-44 CYBB BCL2 GRIA2 NR3C1 PXN PRKCE MAP1LC3A SQSTM1 OPTN HIF1A HEL-S-102 PTK2B HEL-S-32 MIF GSK3B DCTN1 PRKCZ MAPK8 RHOT1 MYD88 BAX PARK2 KAT5 VCP HSF1 CSNK2A2 FOXP3 TUBA1C DLG4 SP1 SGK1 CSNK2B VHL APC TUBB HEL-S-72p APOE TUBA4A HEL-S-67p GSK3A SNCA HSPA4 DLG2 RAC1 IKBKAP CDC20 FREP1 SNCAIP CD133 FAT10 SIRT2 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EGFR PRL CHUK CEBPA PRLR NFIA CEBPB TFPI2 MYC CSN2 ERBB2 NRG1 CLDN6 YY1 ERBB4 DLGAP4 PTPN1 USF2 TTC9 NR3A2 GJB2 GAL ERBB3 NFIB ELF5 BCL2L1 EIF4E ORAI1 PGR HDGFL2 USF1 EIF4G1 TNFSF11 TPM3 NR3C1 TNFRSF11A STAT5B CCND1 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 CDKN2A SUMO1 TNFSF10 TP73 BBC3 OTX2 BAX BOK MDM2 ATM CDKN1A MYC PMAIP1 GADD45A TP63 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 SP1 MAPK1 MAPK3 RBPJ TLR9 CYBB CDC42 NOTCH1 NCF2 DOCK6 CYBC1 NCF1 NOX3 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 KCNN3 C4orf54 DLL4 GTF2I BEND6 EFL1 CYBA SHCBP1 RAC1 IBTK ARHGAP31 EIF6 SBDS BTK TLR8 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ADCY3 ADCY8 SLC16A10 SHH FOXO1 SRC KDM1A CTNNB1 AKT3 RXRA MAPK1 ATF2 RPTOR MAP2K1 MAPK14 MLST8 NOTCH1 RAF1 ITGB3 RPS6KA6 RPS6 RPS6KB1 RHEB AKT1S1 WNT4 THRA AQP7 GSK3B TRH TTF2 TTF1 NPPB ITPR2 MC4R CASP9 NHSL1 TSC2 DUOXA2 SLC16A2 TSC1 TBC1D4 TSHB ACTL6B SECISBP2L DIO1 SIRT6 SLCO1C1 ADRB3 PAX8 PIK3CA MAPKAPK3 ZNF516 PLIN1 PFKFB2 MGLL KDM3B AgRP UCP1 NR1A2 PRDM16 DUOX2 DEHAL1 NPY BAD MAFA FGF21 TSHR MTOR TG SLC26A4 TPO PNPLA2 POMC PPARG FGFR1 MDM2 ITGAV CREB3 FRS2 SLC5A5 PPARGC1A HRAS GRB2 SOS1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK10 MAP2K5 MAPK9 MAPK8 RPS6KA2 CSNK2A1 PIK3CA AKT3 MAP2K3 EIF4EBP1 MAPK1 MAP2K4 MAP2K6 MAPK3 RPTOR MAP2K1 MAPK14 MTOR MAP2K2 PIK3R2 EIF4A2 PIK3R1 EIF4A1 PIM1 EIF4E PIM2 EIF4B RPS6KB2 EIF4G1 RPS6KA4 RPS6 RPS6KA5 RPS6KA1 RPS6KB1 PIK3R3 PRKCA THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK9 MAPK8 RELA STAT1 STAT3 RELB STAT4 GAB2 SRC NFKB1 EIF4EBP1 MAPK1 FYN MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA LYN MAP2K2 TEC YES1 IL7R TSLP FES CRLF2 RPS6 NFKB2 JAK1 STAT5B BTK LCK SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida MAT1A MTRR MTR AHCYL2 MTHFD1 SHMT1 DNMT3B 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome SLC35G3 RPL23 SRCIN1 SLFN12 CACNB1 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 TCF2 SLFN5 CCL13 GRB7 CCL11 GGNBP2 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 CCL5 ERBB2 CCL7 ZNHIT3 LYZB C17orf78 CCL2 CCL4 CCL1 ASIC2 TEC CCL18 RFFL GAS2L2 SOCS7 ACACA CCL16 LHX1 HEATR9 CCL15 TAF15 TMEM132E RASL10B PCGF2 SYNRG EPOP FNDC8 PEX12 PLXDC1 NLE1 ARHGAP23 TBC1D3K STAC2 TCAP CDK12 SPMAP1 PIP4K2B PNMT PPP1R1B DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I MRM1 AATF IKZF3 MMP28 CISD3 DUSP14 TBC1D3H CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 UNC45B MED1 CCL3 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 HEL-S-130P PDX1 CTNNB1 MSRA GATA4 MAPK1 MAPK3 NKX6-1 SLC2A4 RAF1 BMP1 MTMR8 MTMR9 NUMA1 MTMR6 TERT PINX1 HEPACAM2 TBX5 SOX7 SLC35G5 PRSS55 NEIL2 BLK CSTA MCRS1 TNKS PRSS51 S100A10 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 FAM167A FCGR2A FCGR2B AXIN1 XKR6 PPP1R3B FDFT1 CLDN23 SLBP ERI1 TERF1 SGPL1 CGAS HSPD1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA VEGFA ERBB4 MGRA ADAM10 SMC1A MAT1A BMP2 SH2D4B FAM25A BUB1B SMC3 ADIRF LDB3 GHITM IQUB WAPAL NFKB1 ROPN1L RSPH6A ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 SH3GL3 DYDC2 DYDC1 ZMYND11 RGR RSPH9 PDS5B PDS5A GPR15LG RAD21 SNCG TNFSF11 GPR15 PPARG SUSD2 RSPH3 GLUD1 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 BMPR1A LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 OPN4 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 RPE PRPS1L1 DERA OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP9 CNTF CXCL2 CCL14 CCL13 CCL23 CCL11 CCL3L3 LIF LTA CX3CL1 CCL8 CCL5 CCL19 CCL7 CCL28 CCL2 CCL4 CCL1 CCL18 CCL16 CCL15 IL25 IFNA6 IL12B TNLG7A IL12A IFNG IL23A IL17F IL17D IL17C IL17B IL17A IF2B1 IL15 IL-21 TGFB1 CXCL12 IL10 IL13 IL2 IL4 IL5 CXCL8 SPP1 IL3 IL9 CSF2 MMP3 IL1RN CXCL17 CXCL13 IF2D CXCL11 CXCL14 IF2G IL36A IL1A IL36B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 EBI3 IL36RN IFNA21 IF1AA9 TNFSF13 IL36G PPBP VEGFA IFNW1 IL1F10 CXCL6 IL24 IF1IB1 IL27 CXCL3 IL7 IFNA8 CSF1 PF4V1 IL11 IL19 XCL2 TNF IFNK XCL1 CTF1 IFNL2 IFNL3 CCL17 CCL20 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 IFNA7 OSM CSF3 EPO NFKB1 IL6 IFNA2 CXCL5 TSLP CXCL16 CCL4L2 IL18 IFNB1 IL1B CXCL9 IFNA1 CXCL1 AREG CCL3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 FADD CASP9 CASP3 BAK1 APAF1 DIABLO BAX TNFSF6 CASP6 PRF1 FAS HTRA2 CASP8 AIFM1 CYCS TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors EIF1AX EEF2 EIF2S2 SUI1 EIF3S3 EEF2K EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF4EBP1 EIF4A2 EIF4A1 EIF4E EIF4B EIF4G1 GSPT2 EEF1B2 EIF4H EIF4EBP2 EIF4EBP3 EIF2AK2 EIF2B1 PAIP1 EIF5A EIF5B EIF2B3 CLUH EIF2B2 EIF1AY EEF1A1 EEF1G EIF2AK1 EIF6 EEF1A2 EIF2B5 ETF1 EIF2S1 PABPC1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E PIK3CD RAF1 TSC2 PRKAA1 TSC1 PIK3CA PIK3R3 MAP2K3 EIF4EBP1 MAPK1 MAP2K6 MAPK3 MAP3K5 MAP2K1 MTOR MAP2K2 HEL164 PIK3R2 MAP3K11 PIK3R1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y2 DUX4 MYF5 EP300 VEGFA PAX7 TRIM63 ADRB2 CDKN1A MYC FBXO32 PPARGC1A NR3A2 MYOD1 MYOG RET H3Y1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation TAF5 MIXL1 HOXA1 EZH2 PAX3 RGS10 CTBP2 GATA4 ZIC5 LHX1 ELAVL1 SESN1 LAMC1 GATA6 TCF4 C1QBP FOXH1 SOX7 PLCH1 APP TGFB1 TBX21 CRTC1 PIAS1 NABP2 DKK1 DNMT3B MAD2L2 BMPR1A NKX2-1 CAND1 SIAH2 SMAD2 SMAD4 SLC2A12 STAT1 TET1 TCF2 FOXO1 POU5F1 SFRP1 CUL4B CTNNB1 MAP2K3 SOX2 FOXA1 NOTCH1 ACACA BMP7 OTX2 FOXA2 NR3C1 LEF1 PTHLH TCF7L1 WNT3 PABPC1 WWC1 SOX21 SOX17 CEP250 CER1 WDHD1 SFMBT1 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF CEBPZ ATP8B2 PBX3 FOXN3 GDF3 DUSP4 APC ZFHX4 TRERF1 PBX1 EXT1 SP4 PAF1 TAF4B NODAL TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 JARID2 DUSP5 VAV3 DUSP2 WNT8A NOG PARP8 NR1B3 TOX3 AEBP2 Pax9 AHDC1 BTAF1 TCEAL2 LEO1 KDM4A ZNF462 ELP4 LRPPRC TNRC6C ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway PLAGL1 EGFR CD36 KLF6 NCOA7 PTGS2 RELA EP300 NRAS VEGFA SRC NFKB1 AHRR MYC CDK2 MAPK1 TNF KRAS FGF21 CCL1 MAP2K1 NCOR2 GCLC RAF1 NFE2L2 CDKN1B LPL NQO1 CYP1A2 NF1 CYP1B1 CDC37 CYP1A1 AIP CDKN1A RB1 HRAS AHR RET GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG INS IL6R IL6 GLP1R SLC2A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP INSR STAT3 LEPR INS PDPK1 PIK3R3 SOCS2 DGKZ SOCS3 SOCS1 IRS1 IRS4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 REN MGRA ACE2 AGTR1 DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SCN8A PRR5 MAPKAP1 KCNA2 CHD2 PCDH19 SCN3B SCN3A SCN1B SCN1A PIK3CA SNTA1 NFKB1 SCN2A SCN4B SCN2B HCN1 TNF MAPK11 MTOR STXBP1 MLST8 CALM1 FGF13 PRKCA RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB1 PLCB2 GNAI1 S1PR3 PIK3C2B GNAI3 SPHK2 SPHK1 MAPK7 PLCB3 AKT3 MAPK6 SMPD2 MAPK1 S1PR2 MAPK4 MAPK12 S1PR5 MAPK3 S1PR1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MEF2C CAMK2A TET2 CNP CTCF TET1 MBP EZH2 IGF1 FUS IGF1R CEBPD BDNF TARDBP GRIN1 DLX5 PSIP1 YBX1 CDON RBFOX1 HEL-S-20 TAP1 NCOR1 POU3F2 HNRNPH1 GPRIN1 TET3 DLX6 FOXG1 NREP FUT8 PRPF38A RPS6 GAD1 HDAC1 GRIA3 IGF2 GRIA4 POU4F1 SST HNRNPF TAF1 FKBP5 REST SP3 BCL6 MYT1 SMC3 UBE3A SP1 SGK1 APOC2 MTOR OPRK1 NF1 FGF2 FGF7A PTEN CREB1 FGF5C SIN3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SC5D DHCR7 HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB COL5A3 COL5A2 LAMB2 COL3A1 ITGB5 COL4A2 COL4A1 LAMC1 ITGB6 THBS1 SDC2 ITGA1 COL6A1 LAMA4 COL1A2 THBS2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling GSK3B PDHA1 CYP24A1 TSC2 TSC1 RELA CD80 IL10 SLC2A3 PIK3CA IL12A MYC PFKFB4 HEL-S-133P RXRA PRKAA2 NR1i1 HK3 HLA-DRA MTOR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling CIP2A RGMA DCSTAMP MYF5 COL1A1 CASP3 YAP1 CTGF IL10 JUN NEO1 SRC PIK3CA KDR AGAP2 MAPK1 TNF ARHA FYN MAPK3 INPP5D CCL2 PTPN11 MAP2K1 MAPK14 MAP2K2 SELE PPP2R1B RAF1 ALPL ITGB4 PRKCA PTPA RAC1 ROBO4 NTN1 PTK2B RLF NTN3 PLEKHH1 ARHGEF12 VCAM1 UNC5B IL1A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5 NRF CD8B1 CD3G PRG3 CD3E CD2 IGLL1 CD8A CRP LBP ZAP70 MMP25 HLA-DRB1 IL6 CXCL8 HLA-DRA FYN LCK FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia EGFR MRE11A DCLRE1B CTDP1 UHRF2 FAAP24 CEBPD BRIP1 RAD50 SLX4 RAD51 MEN1 FANCM CENPX FANCL REV1 UBE2T FANCA FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C FANCD2 RFWD3 ERCC1 HEL-S-125m CENPS MCM2 SMARCA4 FAN1 MAD2L2 ATM NBN ATR UHRF1 PTEN BRCA1 BRCA2 USP1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IRAK1 PDLIM7 MAPK8 CHUK RELA TRAF6 IKBKG MAP3K7 NFKB1 TRADD NFKB2 IFNB1 CXCL8 IKBKB CCL5 MAPK1 TNF MAP3K14 TRAF1 NFKBIA CCL20 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA MAFG FBL CREBBP IRF2 SMAD4 HEL23 DDX21 CREB1 FOXO1 NPAS2 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling MEF2D STAT1 TRAF2 MAP3K1 TGFBR1 SHC1 MAX MYC MAP2K4 DDIT3 MAP2K6 MAP3K5 ATF2 MAPK14 SMIM40 CDC42 RASGRF1 HMGN1 MAPKAPK5 RPS6KA5 RIPK1 MAP3K7 TRADD CREB1 RAC1 HEL-S-102 HRAS GRB2 MAPKAPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHS1 ACSL5 ACSL3 ACACA FASN PECR MECR PC ACSS2 ECHDC1 ECHDC2 DECR1 ACLY ACACB SCD ACSL1 ACSL6 FACL4 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway MASP2 HEL-S-62p C3AR1 FCN1 C6 C7 COLEC11 C9 ACE2 C5AR1 C8A ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP IL2RG CRLF2 STAT3 IL25 FCER1G IL13 IL1RL1 FCER1A TYK2 MS4A2 IL13RA1 IL4 IL5 OSMR JAK3 IL33 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways MAT1A NNMT TPMT INMT PNMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ME1 BCAT2 HMGCR PFKL ACLY SLC7A5 DLD SOAT1 KRAS HEL-S-30 HK2 GNPNAT1 PDHA1 LDLR GOT2 FASN CS GLUD1 PDHX RPIA GLS2 RPE PGM3 HEL-S-133P DLAT GPT SLC16A4 CARM1 HEL-S-32 GFPT1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG2 PDHA1 ACACA FASN PRKAG3 PRKAA1 LIPE PRKACG ACSS2 PRKAB2 ACLY PRKAB1 HILPDA PLIN1 AKT3 PRKAA2 PRKAR1B PRKAR1A ABHD5 PNPLA2 PRKAG1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR4 IRAK4 IL2RG TGFB1 STAT3 CD80 TRAF6 NFKB1 IL4 NFKB2 SOCS1 CCL5 CCL2 TGFBR2 CTLA4 IL2RA TLR8 TLR7 IL2RB PDCD1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA PRKDC CHAF1B NASP MCM2 HAT1 ASF1A ASF1B H4C9 HIST1H4L CHAF1A RBBP4 SUPT16H XRCC5 SMIM40 SSRP1 CHEK2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP2A6 XDH CYP1A2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TLR4 MMP9 IRF7 CREBBP STAT2 EP300 EGR2 SRC TYK2 SOS2 NFATC3 NFATC2 NFATC4 IKBKE IFNA6 MAP3K7 DDB2 PIK3R3 STAT5B PTK2B JAK3 MAPK10 MAPK9 MAPK8 TGFB1 STAT3 ARAF BAX STAT4 NFATC1 CXCL8 CASP8 VDAC3 PIK3R2 PIK3R1 FADD IKBKB CASP12 JAK1 HRAS IFIH1 TGFBR2 IRF3 TLR3 IFNA13 BIRC5 IFNA14 IFNA16 SMAD2 IFNA17 SMAD4 IFNA10 TICAM2 HSPG2 RELA STAT1 IFNA21 DDX3X TRAF3 IF1AA9 CASP10 BRAF TIRAP NRAS DDB1 MAP3K1 TGFBR1 MAP3K7IP1 FAS MYC IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 KRAS MAP2K6 MAPK3 MAPK13 ATF2 MAPK11 MAP2K1 MAPK14 MAP2K2 BCL2 RAF1 CREB3L3 CREB3L4 TNFSF6 PRKCB IFNA7 TICAM1 PRKCA CYCS ATF4 IRAK1 PIK3CD IRAK4 CASP9 MYD88 CASP3 CHUK APAF1 TRAF6 TBK1 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD PCNA YWHAQ HEL-S-1 CREB3L2 FOS YWHAZ CREB3 CDKN1A IFNB1 CREB1 CREB5 IFNA1 GRB2 SOS1 ATF6B NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A5 MYH9 LAMB2 MYO1E SCARB2 SMARCAL1 CD151 HEL-S-47e PTPRO COL4A4 GPC5 APOL1 TRPC6 SYNPO YARS EMP2 ALG1 WDR73 COQ6 ARHGAP24 COQ2 PAX2 WT1 CD2AP INF2 NPHS1 CTLA4 CYP11B2 PLCE1 ACTN4 NPHS2 COQ8B LMX1B E2F3 ITGB4 ZMPSTE24 LMNA CUBN COL4A3 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 THRAP3 MORC3 ELL BCLAF1 SETX STK38 TRIM35 RBBP7 SUZ12 EZH1 EZH2 JARID2 AEBP2 RBBP4 EED COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 HEL-S-78p F13B PLG F13A1 FGA BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage TNC REN TCF2 BMP4 SFRP1 DKFZp781O1323 KDR PAX2 WT1 RSPO1 NPHS1 NPHS2 NOTCH2 NOTCH1 LHX1 HNF1A tmp_locus_29 BMP7 NR2A1 CITED1 TCF21 SALL1 SIX2 RSPO3 DACT1 EMX2 FOXD1 OSR1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 WNT4 TBX18 NTN1 GDNF TLX1 FAT4 DCN VSX2 ACTA2 EPO AXIN2 SIX1 SMAD1 FGF7 FGF8 PBX1 NT5E IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 IDO1 GOT2 IFNG AADAT TNF KMO KYNU KYAT3 KYAT1 IDO2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF PGR FOSL1 MYC HEL113 ERBB2 CCND1 TIMP1 AREG HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC RBX1 CBFB NAE1 UBA3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B PTPRN CAMK2A SCN11A PDCD10 SCN7A SCN8A SCN5A PRRT2 MAPK8IP2 SCNM1 SCN4A RNF121 NEDD4 SCN3B SCN3A WEE1 SCN1B SCN1A SCN2A SCN4B SCN2B TNF FYN FGF14 CALM1 FGF13 FGF12 PSEN1 SCN9A BACE1 SCN10A ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC5 CDKN2A BAK1 TRAF3 CASP10 FAS MAPK3 MAP3K5 NFKBIA BCL2L11 SMIM40 BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO PIDD1 TNFSF6 CASP6 RIPK1 AIFM2 IL1R1 PMAIP1 TNFRSF10B AIFM1 BLK PRKD1 MCL1 CYCS IRAK1 BIRC7 TNFRSF10A CASP9 MAPK8 MYD88 CASP3 APAF1 BAX TRAF6 HRK TNFRSF6B BIRC2 CAPNS1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 PTRH2 MADD TNFRSF25 NAIP BCL2A1 BCL2L10 CASP8 BAG3 MAP3K14 BMF CRADD BAD BIK BNIP3 TNFRSF10C SEPTIN4 PTPN13 TNFRSF10D BCL2L2 FADD FOS TRADD IKBKB TNFRSF1B HTRA2 IL1R2 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling CREBBP HDAC2 CTBP2 MAML1 DTX1 RBPJ NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 APH1B ADAM17 MAML3 RBPJL JAG2 CTBP1 DTX2 DTX3 PSEN2 DTX4 LFNG KCNJ5 HDAC1 DTX3L PSEN1 KAT2A MFNG HES1 DLL3 DVL1 HES5 DLL4 DVL2 DVL3 KAT2B METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX12 PTGS2 ALOX5 ALOX15 FADS2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 RPTOR MAPK11 MAP2K1 MAPK14 MAP2K2 PRKAG1 MLST8 PRKAG2 PRKAG3 PRKAA1 PRKAB2 RPS6KB1 PRKAB1 CDC2 EEF2 EEF2K MTOR CALM1 UQCRB COX7C RPS6KA1 RAB5IF MOSMO UQCR11 NDUFS8 UQCR10 CYB NDUFS3 COXFA4 CDH18 UQCRH COX5A UQCRQ TRPM7 UQCRC1 PDZD9 UQCRFS1 CDR2 CYC1 NDUFA9 SDR42E2 UQCRC2 VWA3A POLR3E FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 RPS6KB2 TSC2 FSHR RPS6 RPS6KB1 FOXO1 RHEB SRC PRKCA FSHB CREB1 EIF4EBP1 MAPK1 SGK1 MAPK3 H3-4 APPL1 MAPK14 MTOR CGA PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 BIRC5 PTGS2 RELA CHUK CXCL2 RELB TRAF6 VEGFA BIRC2 BIRC3 TNFRSF1A NFKB1 IL2 IL6 CXCL8 BCL2A1 TNF SELE BCL2L2 NFKB2 CD40LG IKBKB EGLN2 MMP2 IL1B CSF2 MMP3 REL CCND1 VCAM1 IL1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C8 NR1C1 PPARG CYP4F2 CYP4A11 CYP4F12 CYP2C18 EPHX2 CYP4A22 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C2 NR1C1 CD36 CYP2C9 NR1i1 NPC1L1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A ADCY1 ADCY8 GNAI1 ARAF PPP1R1A GRIN1 PPP1CC RAP1A HEL-S-80p MAPK1 MAPK3 GNAS MAP2K1 MAP2K2 GJB1 CALM1 RAF1 ACTG1 GRIA2 GRIA3 PS1TP5BP1 PRKACG GRIA4 PRKCB PRKCA DRD1 DRD2 CREB1 DRD4 ACTG2 CAMK4 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 UGT2B7 AKR1D1 AKR1C1 AKR1C4 AKR1C2 UGT1A10 CYP11B2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB4 PLCB1 CACNA1A PLCB2 GRIA2 GNA14 RYR3 HOMER3 CA8 GRIA3 GRIA4 GNA11 TRPC3 GNA15 PLCB3 ATP2B2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 NFKB1 TGFB1 RASGRF1 STAT3 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling GSK3B MAPK9 MAPK8 CASP3 RELA CHUK TRAF3 RELB TRAF2 BIRC2 BIRC3 JUN NFKB1 CTNNB1 MAPK1 TNF CASP8 MAP3K14 MAPK3 MAPK14 NFKBIA NFKBIB FADD RAF1 HDAC1 RIPK1 MAP3K7 TWEAK TRIM63 TNFRSF12A NFKB2 IKBKB RAC1 TRAF1 TRAF5 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP9 SMAD2 CACNB1 SMAD4 MCUB SCX TOMM20 SLN TGFBR1 SGCA CAPN3 TRPC1 TRDN STIM1 CASQ1 TNNI1 DMD CACNG1 PRKAA2 PLA2G2A TNF FKBP1A SSPN SNTB1 NFKBIA AGTR1 CYBB ORAI1 PPIF CACNA2D1 PRKAA1 MPO CACNA1F FGA HEL-S-78p CACNA1S MCU DAG1 ATP2A1 ITPR2 CASP9 TGFB1 PRG3 CTGF IL10 TRPC6 SLC25A5 NFKB1 TRPC3 IL6 SPP1 NOS2 ELANE RYR1 SIGMAR1 NOX4 MMP2 IL1B CAMK2D TGFBR2 IL1A CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2C TLX2 MEF2B KLF4 ID2 MEF2D STAT3 RUNX2 EZH2 PAX7 HDAC5 LEFTY1 TLX1 SOX2 TLX3 MYOD1 LEFTY2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway RAF1 MAPK8 STAT1 STAT3 MAP3K1 PLCG1 JUN PRKCB EIF2AK2 PIK3CA SHC1 FOS PRKCA MAP2K4 STAT5B MAPK3 JAK1 HRAS MAP2K1 GRB2 SOS1 PIK3R1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT2B MAPK10 MAPK9 MAPK8 WNT7B WNT16 WNT7A CTNNB1 LRP5 LRP6 ARHA INVS WNT5B NPHP3 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT9B FZD7 FZD9 FZD8 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A ID2 ARCN1 ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B FLT3 ZBTB16 PYGO1 BCL9 WIF1 SALL4 RARA RUNX1T1 LEF1 PML CSNK1A1 AXIN2 NR1C2 JUP CTNNB1 TCF3 DKK1 MYC LRP5 WNT1 LRP6 CCND1 APC SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK GPX2 RELA DIO1 JUN NFKB1 TXNRD3 SP1 GPX1 CTH FABP1 NFE2L2 RPL30 HEL-S-134P SELENOF GPX3 SELENOI TXNRD2 SELENOH SEPHS1 CREM SEPHS2 PSTK EEFSEC POU2F1 GPX6 FOS TRNAU1AP SELENOO SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SELENOW GPX4 SELENOV SELENOT SP3 MSRB1 SELS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias FECH UROD UROS HMBS CPOX ALAS1 ALAS2 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EGFR ADAP2 HOXA1 MAP3K1 RAD51 OMG MAPK1 MAPK3 SUPT5H BCL2 EGF CRY1 RAF1 RBBP7 EZH1 CCNA2 CCNE2 SDC2 MCL1 PER1 RTN4R HEL-S-15 RAD9A WDR48 NGFR HOXA9 H3C8 EXOC8 EXOC7 RFC2 MYT1 ARF6 POLRMT EXOC4 EXOC3 MAP3K2 EXOC6 ROCK2 RFC3 EVL RFC4 EXOC5 EXOC2 EXOC1 H3C15 INPP5A E2F6 RAB11FIP4 TEFM UTP6 LIMK1 MAVS ATAD5 ARHA RAB11A RIGI EED COPRS EVI2A CRLF3 EVI2B METAP2 PCNA TUBB SUZ12 NF1 CCNE1 JARID2 H4C9 ATR HIST1H4L NGF IFNB1 USP1 SYN1 SOS1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 LEP ACACA ADIPOR1 ADIPOR2 PRKAA1 CPT1A LEPR PRKAG1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 NUP107 NOTCH1 HCTP4 GATD3 KIF15 AURKA SMOC2 CENPF ESM1 RUVBL1 MYBL2 ECT2 KIF20B E2F7 TOP2A H4C9 UBE2C ACTL6A S100P CEP192 H3F3B LIN9 APC INO80D VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 F7 PROC AIFM2 NQO1 PROS1 VKORC1 UBIAD1 F10 F9 GGCX PROZ 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation DAG1 MAPK9 MAPK8 TRAF3 TRAF2 SGCA SNTA1 LINGO1 DMD ARHA SSPN SNTB1 CDC42 MIPEP SACS RTN4 C1QTNF9 SGCD ATXN1 SGCB SGCG TNFRSF19 C1QTNF9B SPATA13 RAC1 TRAF1 TRAF5 RTN4R TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling CREBBP NRAS MAP3K1 MAP3K7IP1 KSR1 TNFAIP3 SMPD2 MAP2K3 MAP2K4 MAPK1 TNF KRAS MAPK3 MAP2K6 MAP3K5 NFKBIA RFFL NFKBIB BCL2L1 RAF1 DIABLO CDC37 MAP3K8 RIPK3 MAP3K7 RIPK1 NFKB2 CYBA REL TRAF1 PPP2CA TANK CASP9 PRKCZ MAPK9 TAB3 PIG59 MAP4K2 MAPK8 CASP3 CHUK APAF1 BAX TRAF2 TBK1 IKBKG BIRC2 BTRC BIRC3 SKP1 JUN CSNK2A1 TNFRSF1A TXN NFKB1 MADD CASP8 MAP3K14 FBXW11 BAD PSMD2 PLK1 FADD TRADD IKBKB TNFRSF1B OTUD7B RAC1 PYGL HRAS KSR2 PTPRCAP NSMAF GRB2 NFKBIE SOS1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence CYP4F8 SLCO2A1 HEL-S-53e DPEP2 ALOX12 LTC4S NAT2 PTGS2 ALOX5 HEL-S-22 ALOX15B ALOX15 ALOX5AP GPX1 FADS2 MAPK11 EPHX2 PTGES3 FADS1 ELOVL5 SIRT1 HEL-S-298 HPGD AKR1B1 DECR1 PTGS1 CDKN1A RB1 PTGIS PRXL2B ALOXE3 ELOVL2 PTGES PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway WNT2B TF NTF4 FST CNTF FLT3LG KITLG TGFB1 INHBA GDF5 EPO PDGFA IGF1 VEGFA BMP4 SHH WNT7B ALK INS FGF10 CSF1R HGF DKK1 IL6 CSF1 IL11 LEFTY1 FGF8 TPO IL3 NOTCH1 EGF TNFSF11 NODAL FGF2 FGF7A NOG IL6R WNT1 KIT NT5E CXCR1 WNT3A FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IRAK1 TLR4 IRAK2 IRAK4 MYD88 TICAM2 RELA CHUK LY96 LBP TIRAP TRAF6 IKBKG SRC PIK3CA NFKB1 CXCL3 IL6 TNF ARHA NOS2 CCL2 SYK ITGAM PLAT PLG FGA IL12B FCER1G TICAM1 HEL-S-78p IFNB1 IKBKB REL TYROBP IRF3 CD14 TLR3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYS2 GYS1 HEL-S-19 PYGL AKR1B1 SLC2A2 GYG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BIRC5 SMAD2 SMAD4 PTGS2 BAK1 DCC BRAF MSH3 TGFBR1 CSNK1A1 CTNNB1 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 BCL2L11 BCL2 RAF1 BBC3 LEF1 RAC3 DDB2 TCF7L2 TCF7L1 PMAIP1 REL GADD45B NTN1 GADD45G CCND1 CYCS GSK3B MAPK10 POLK CASP9 MAPK9 MAPK8 CASP3 TGFB1 ARAF BAX AXIN1 TBK1 AXIN2 MSH6 JUN MSH2 EXOC2 ARHA BAD GADD45A APC CSNK1A1L FOS CDKN1A RALB RAC1 APPL1 APC2 TGFBR2 RALA PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1A2 CAMK2A PDE3B ADCY3 ADCY1 ADCY8 PDE4A ADCY6 PDE3A GUCY1B1 PDE1C PDE1B PDE1A HEL-S-7a GRIN1 PDE11A PPP1R1B PDE6D PDE6C PDE6A PDE8A PRKG1 PDE6H PDE6G PDE2A PDE10A PDE12 PDE5A PDE7B PDE7A ADORA2A PDE9A CHRNA7 PDE4B PDE4D GRIN2B DRD1 DRD2 CREB1 ADCY9 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway CERS5 PLPP1 ACER1 SPTLC3 CERS2 SERINC1 CERT1 ASAH2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 PPP2CA KDSR VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREBBP HLX TRPC1 KDR HEL-S-68p GATA2 ACKR3 PDPK1 PRKAA2 SHC2 MLST8 VPS39 EIF4E TPM3 ADAM10 RPS6 NCL RPS6KB1 PTMAP7 PLA2G5 PXN AKT1S1 ACACB SARS1 CAMKK2 SDCBP PTK2B CCND1 OCRL TBCA EIF3S3 HEL-S-162eP NFATC1 EIF3F EIF3D DKK1 RAP1A CXCL8 CYR61 RAB11A MMRN2 PIK3R2 PIK3R1 RAPGEF1 FADD MDM2 HEL-S-128m NOX4 TEAD4 PPP3CA MMP2 RAC1 HRAS ANXA1 MMP10 SLC2A14 MMP14 ABCF2 PAK1 PTGS2 RELA STAT1 VEGFA FAS CTNNB1 HMGB1 HBEGF MAP2K3 PRKG1 MAP2K4 MAPK12 MAP2K6 MAP3K5 GPX1 MAP2K1 MAPK14 MAP2K2 CYBB RAB5A ERN1 BCL2L1 ACACA RAF1 RPL5 HEL114 RPL7 RPL18A LUC7L UBAP2L CHAC1 EPHA2 EPHB2 RPS11 FGA IER5 EIF2A ACOT9 TMEM170A SND1 INPP4B HEL-S-78p hEMMPRIN KATNAL2 EWSR1 BIN1 TXNIP ALB RPL27 PRKD2 PRKCI RPL26 PPP2CA PFN1 PABPC1 EZR HEL164 ATP6V0D1 MAPKAPK2 CYCS FLII GIGYF2 GSK3B HEL-S-15 DHX36 XB MYO6 MICAL2 PRRC2C LARP7 SRPK1 CALU HYOU1 DHX29 FAF1 KCNC3 CRK CCDC124 ROCK1 SRP54 ROCK2 HBD SHB EEA1 PIK3CA CSRP2 TMSB4X RPLP2 CGNL1 SSR4 SSR3 FJX1 LIMK1 ENG ARHA KANK1 HEL-S-87p CRIP2 SLC7A1 MTOR APOLD1 FGD5 GPC1 FLNB NUMB CDC42 CCT7 BRD4 AAG1 PRKRA TFAM TAOK2 COPG1 FOXO3A GLUD1 FHOD1 ITGB5 CTNND1 PLOD3 RPL10A AMOT CBL EPRS1 tal-1 CCRL2 P4HA2 TMSB10 ITGAV DUSP5 TMOD1 TMOD3 SEMA6D DPM1 FARSB DOK1 DLL4 ARMCX1 RAB37 ADAM9 FRS2 ZNF555 DSC1 LRRC59 HTRA1 FUT1 GRB2 QK3 IGFBP7 ZC3H15 HEL-S-94n SDF2L1 MEF2C HEL-S-84 BMX TPP1 ITGB1 AFDN RCAN1 TFCP2 CNP NR4A3 SPIRE1 GRSF1 MAPKAP1 C15orf39 FHL2 NRARP LDB2 VAV2 RND1 SET CAPZB LRRFIP2 ADAMTS9 SRC SHC1 ARHGEF15 SHROOM2 RPL13A HDAC5 SLC25A11 PPM1G HDAC9 DNAJB4 HDAC7 FAM120A DNAJB9 FYN WASF1 NFATC2 CCL2 SLC25A25 PTPN1 PDE4DIP PTPN11 NFKBIA CDC42BPB FMNL3 PTPN9 PTPN6 CTNNA1 ITGB3 RPS6KA5 GRB10 BMP10 ELOA HEL-S-133P RAB4A PLAUR MAPK9 MAPK8 STAT3 ARF6 CTGF TXN MYO1C HEL-S-99n TUBB8 TUBA1C TRPC3 NRP2 PSMD4 FBXW11 F3 SELE LMAN1 MAPKAPK5 PSMD11 DECR1 SIAH2 EGR1 HEL107 ATP6V1E1 CYP2C8 BIRC5 KL MYH9 ERG TRAF3IP2 FLT1 FOXO1 HEL-S-2a PNP MAPK1 MAPK3 ATF2 HEL2 BCL2 SLC8A1 ACTG1 EIF4G1 CACNA2D1 PRKAA1 GJA1 HDAC1 NCF1 PRKCB PRKCE FXR2 PRKCA HEL-S-102 MYL2 PRKD1 BMP2 ATF4 ELOC MOV10 PRKCZ PLCG1 JUN ARF4 NFKB1 TNFRSF25 NAPA TNFRSF10C SH3BGRL3 CLTC HGS SH2D2A AP2A1 NCF2 IQGAP1 ARRB2 FOXO4 AP2S1 SYNJ1 NCK1 EPN1 ADRB2 PLCB3 CREB1 RICTOR CSK S1PR1 ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 AGTR2 REN ACE2 AGTR1 CYP2R1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HEL-S-53e HAT1 HDAC2 HDAC10 DHFR ADH1A HDAC5 HDAC8 ADH1C HDAC9 HDAC7 HDAC6 ATF2 HEL-S-117 ALDH2 SLC19A1 ALDH1A3 MTR HDAC1 ACSS2 TYMS CYP2E1 MAT1A ALDH1A2 HDAC3 KAT2B SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 TRAF3 IF1AA9 TBK1 IFNAR2 TYK2 IFNAR1 IFNA8 MAVS RIGI IFNA2 ACE2 IKBKE IRF9 IFNA6 IFNA7 TICAM1 IFNB1 JAK1 IFNA1 IFIH1 IRF3 TLR3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 NFKB1 MAP1LC3A IFNG IFNB1 MYD88 TNF TRAF6 IRF3 TLR9 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 CD36 LAMB2 CXCL12 FOXC2 FOXC1 TCF2 VEGFA SHH KDR CTNNB1 PAX2 WT1 SIX1 CD2AP FGF8 NPHS1 NPHS2 NOTCH2 HEL-S-28 LMX1B LHX1 ROBO2 CXCR4 FGFR2 HOXD11 HOXA11 SLIT2 TCF21 GLI3 KIRREL1 ETV4 MAFB NCK2 EMX2 NCK1 FOXD1 EYA1 WNT4 GDNF RET INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 IF1AA9 IFNAR2 IFNW1 IFNGR1 PIK3CA IF1IB1 TYK2 IFNAR1 IFNA8 IFNK IFNA2 IFNL2 IFNL3 PIK3R1 IRF9 IFNA6 IFNL4 IL10RB IFNGR2 IFNLR1 IFNA7 IFNE PRKCA IFNB1 IFNG JAK1 IFNA1 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling GSK3B CREBBP NR2F6 STAT1 STAT3 CRP VAV1 SHC1 TYK2 SOCS3 IL6 NLK MAPK1 MAP2K4 MAPK3 BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2L1 PRDM1 HDAC1 RPS6KB1 MAP3K7 JUNB IRF1 IL6R VIP RAC1 JAK1 GRB2 NCOA1 TIMP1 SOS1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG INS PCSK2 PCSK1 GLP1R NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NKX2-1 FOXG1 TGIF1 NODAL TGIF2 GLI3 FGF8 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PLCB4 ITGB1 EGFR PAK1 FLT1 INSR CDH6 FGFR4 CDH2 NRAS DDB1 FOXM1 CDH16 IGF1R KDR PDGFRA CTNNB1 MYC KRAS MET FLT3 CTNNA1 FGFR2 ITGB3 ITGA2B PRKACG EPHA2 NTRK1 ITGA1 CDH9 KIT PAK6 CDH8 PRKAR1B DCAF1 PRKAR1A PAK4 CDH4 ITGA2 CDH10 CDH11 CCND1 CDH12 CDH15 AJUBA ITGA4 CDH17 VGLL4 CD44 ITGB7 CDH19 NF2 CDH24 NGFR WWTR1 PPP1R14A CUL4A LIN28B YAP1 CTGF PPP1CC HEL-S-80p RBX1 CSF1R NTRK2 ITGAM FGFR1 ITGB5 ITGB4 FLT4 ITGAE AMOT ITGB8 ITGAV ITGAX ITGB6 CDH18 LATS1 TEAD4 ITGA7 LATS2 ITGA6 HRAS TEAD2 TEAD3 FGFR3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G6 ACSL3 FADS1 ELOVL5 PLA2G4B FADS2 ACOX1 ACSL1 ACOX3 ELOVL2 FACL4 PLA2G5 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome TUBA2 STAT3 AMER3 STMN2 MZT2A FAM168B CCDC74A CDC27 CCDC42 ARHGEF4 POTEE GPR148 ARHA RAC1 APC PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 ITGB1 MYH9 LAMB2 HEL113 CDH2 MYO1E SCARB2 SMARCAL1 CD151 PTPRO SYNPO CTNNB1 CLDN1 PAX2 FYN WT1 CD2AP INF2 NPHS1 IRF6 NPHS2 HEL-S-28 LMX1B NOTCH1 CDKN1B HEL114 ITGB3 CD80 WNT1 CR1 PLAUR COL4A3 COL4A5 DAG1 LAMA5 TGFB1 PLCG1 CDKN1C COL4A4 TRPC6 MKI67 CTSL KIRREL3 DKK1 VTN KIRREL2 LRP5 TLN1 PARVA LRP6 FAT1 AGRN LIMS1 PLCE1 ACTN4 PCNA ITGB4 YWHAQ ITGAV NCK1 CDKN1A MME EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways LIF PDGFRA PTPN11 EGF FGFR2 SELENOP STAT3 ARAF ACVR1 SMAD1 ACTR2 ERAS ACVR2B PIK3R2 SMAD6 FZD1 WNT10B WNT10A FZD3 MDM2 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 PTEN JAK1 HRAS FGF23 EGFR SMAD4 FGFR4 PDGFA BRAF BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 AKT3 MAP2K3 MAPK1 MAPK12 MAP2K6 MAP2K1 MAP2K2 WNT5B IL6ST HNF1A RAF1 DVL1 DVL2 FGF8A DVL3 WNT1 WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD MAP2K5 AXIN1 JUN WNT16 MAPK7 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC FGF14 FZD4 SMAD9 FGF13 FGF18 FGF12 FGFR1 FGF2 WNT9B FGF7B FGF7A NOG FOS MAPK6 MAPK4 FGF5C GRB2 SOS1 FGFR3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CYP11A1 MAPK10 STAR HEL-S-2a CASP3 BAX HSD3B2 PARP2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A FHL2 GUCY1B1 MAPK1 FHL1 MAP2K1 MAP2K2 ADRB1 MYPN TTN RAF1 CSRP3 NUP62 ANKRD2 HEL-S-101 ANKRD23 C22orf13 MDM2 PRKACG TRIM55 TCAP NBR1 ADRB2 TRIM63 PRKCA PRKAR1A ANKRD1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 SOX17 FOXC2 FOXC1 TCF2 BMP4 GATA3 CTNNB1 SPRY1 PAX2 WT1 SOX11 LHX1 ROBO2 HOXD11 HOXA11 HOXC11 SLIT2 IFT27 GLI3 SALL1 IFT25 ROBO1 SIX2 GREM1 ALDH1A2 EYA1 GDNF FAT4 RET BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs ACACA PCCA PCCB ACACB PC MCCC1 BTD HLCS MCCC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety GCG LEP POMC GHRL MC4R AgRP NPY PYY ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis TLR4 MMP9 STAT1 SGCA SRC SOCS1 DMD MAPK1 TNF FYN MAPK3 HEL-S-28 BCL2L1 BCL2 EIF4G1 CXCR4 CD80 CASP6 RAC3 IL12B IL12A TICAM1 NFKB2 CD40LG IFNG PABPC1 CCND1 CYCS GSK3B DAG1 CASP9 NOD2 CASP3 TGFB1 HLA-DMA STAT3 BAX IL10 CASP2 DFFB DFFA IL2 IL6 TLR5 CCR5 CASP8 CD55 CCR3 PIK3R1 PARP1 AAG1 PS1TP5BP1 PYCARD CAAP1 SGCD EDN1 CXADR SGCB MYH6 SGCG AIF1 CHRAC1 CREB1 BNIP2 ABL2 MICA JAK1 SOS1 TLR3 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NLRP3 IKBKE CHUK RELA FCGR2A TBK1 IKBKG NFKB1 IFNB1 IKBKB IL1B REL GSDMD CGAS NLRX1 MITA F3 NFKBIA IRF3 NFKBIE LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G1B PLA2G4E SLCO2A1 PLA2G4C PLA2G3 PLA2G7 PLA2G10 PTGS2 ALOX5 PLA2G5 PLA2G6 CDKN1A HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYLK EGFR PAK1 ACTR3 DAAM1 MYL1 PFN4 PFN3 PFN2 CAMK1 SRC SHC1 CTNNB1 NEF3 MYC ERBB2 MAP2K4 MAPK1 NEFH ERBB4 NEFL GPX1 HEL-S-44 MAP2K1 TGFA RAF1 CDKN1B DVL1 PPP2CA PFN1 GSK3B MAPK8 AXIN1 FZD10 PLCG1 ROCK2 WNT16 JUN TMSB4X ARHA ACTR2 APC FZD4 FZD1 FZD3 CBL FZD2 FZD5 FZD7 FZD9 NCK1 FZD8 CDKN1A ACTA1 GRB2 SOS1 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 CALM1 STX1A PPP1R10 KCNQ3 PLCG2 AKAP5 P2RY1 CSNK2A1 SCN1B CHRM1 PRKCA BDKRB2 PPP3CC AGTR1 BACE1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A ADCY3 ADCY1 ADCY8 CNTF CAMK2G IL10RA BDNF LIF LTA SOCS3 GFAP GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 IL10RB IFNGR2 IL12B IL12A IL6R IFNG SLC1A4 CAMKK1 CAMKK2 TRAF5 TGFB1 STAT3 IL10 IFNGR1 IL13 PPP1CC ARC IL4 HEL-S-80p SLC2A3 SLC1A1 GRIN2B SLC6A9 GLS2 DLAT JAK1 TGFBR2 IL1A PLCB4 SMAD2 PLCB1 SMAD4 PLCB2 INSR STAT1 IGF1 PSAT1 TGFBR1 PSPH NELF GRIN1 SLC38A3 SLC38A5 DAO GRIK5 SLC1A2 GRIK3 IRS1 GRIK1 SLC7A10 MAPK1 TNF GRM2 GRM4 MAPK3 GRM8 PHGDH SRR LRRC8C IL6ST LRRC8D DISC1 LRRC8E BCL2 HEL-S-51e PRKCB PRKCA NFKB2 IL1R1 SLC38A1 GLS HEL-S-15 PIG59 GRIK2 TGFBR3 TNFRSF1A NFKB1 IL6 DLD CALM1 PDHA1 SLC1A3 SHMT1 FGF2 SLC17A6 SLC17A7 FOS IL13RA1 NGF PLCB3 TNFRSF1B CREB1 IL1B IL1R2 CAMK2D CAMK4 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 ADAMTSL2 EGF ZEB2 LTBP1 ZNF423 pp6425 BAMBI FBN1 LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency CCND2 CREBBP PPP2R3A EP300 PPP2R2C FOXD3 PPP2R2B POU5F1 WNT7B WNT7A CTNNB1 MYC CTBP2 MAP2K4 SOX2 WNT5B ZBTB33 LDLR PPP2R1B PPP2R1A LRRK2 PPP2R2A LEF1 CCND3 FBXW2 PAFAH1B1 PPM1J PRKCH NKD1 NKD2 PRKCB NFYA MAP3K7 ESRRB NR1C2 PRKCE PPP2R3B DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PPP2CA PRKD1 CCND1 GSK3B WNT2B CD44 MAPK10 PRKCZ MAPK9 AXIN1 FZD10 FRAT1 AXIN2 WNT16 JUN CSNK1E LRP5 NLK LRP6 ARHA APC CTBP1 FZD4 FOSL1 FZD1 WNT10B CTNND1 WNT10A FZD3 FZD2 PPP2R5E WNT9B FZD5 FZD7 FZD9 FZD8 PPP2R5C MMP7 PTPA SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway EMC7 MICOS13 OPA1 MFN2 APOOL MMGT1 IMMT EMC10 TMEM85 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 MFN1 EMC6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways SLC25A15 MDH2 ASL GOT2 NAGS SLC25A12 ASS1 GLUD1 ARG1 SLC25A13 LDHB FH OTC GLS2 GPT NOS2 HEL-S-32 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 ARHGEF1 ARHA 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation STX1A CREBBP NECAB3 APP SPEF1 SMC5 RELA SMC6 LYPD6 ENTREP2 UBN1 MLSN2 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J CXNO CGN CCL5 GOLGA8R GJD3 MTMR10 CANX KLF13 MYZAP OTUD7A TJP3 GOLGA8O CDC42BPB GOLGA8Q TRPM1 FANCD2 STXBP1 GOLGA8H CALM1 FAN1 CHRNA7 ANKRD2 GJA1 HDAC1 CXADR TJP1 SIN3A KAT2B STX1B IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta TF HAMP IREB2 TFRC HEPHL1 TFR2 SLC40A1 MCOLN1 SLC11A2 HEL60 STEAP3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 NR1C2 FFAR3 PYY FFAR2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 SGPL1 PEMT CHPT1 CEPT1 PISD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL OTC NAGS F7 GLS2 ASS1 GPT ARG1 F10 HEL-S-20 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling PIK3CD IL2RG RELA EP300 CHUK STAT1 STAT3 GAB2 CEBPA CEBPB PIK3CA SHC1 TYK2 NFKB1 IL4 SOCS3 SOCS1 IRS1 MAPK1 FLNA MAPK3 INPP5D BAD ATF2 PTPN11 MAPK11 MAPK14 NFKBIA PIK3R2 PTPN6 PIK3R1 FES SOCS5 CBL RPS6KB1 FOS IKBKB JAK1 STAT5B JAK3 GRB2 SOS1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CAP1 ELOVL5 IGF2R LPL CYP1B1 CEBPB PICALM SRSF9 TMED10 TMEM43 PHC2 TGFBR2 SRSF10 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling GSK3B ITGB1 SMAD2 WASL MAPKAP1 IGF1 IGF1R TNFRSF1A NFKB1 IRS1 RPTOR MTOR DEPTOR ACVR2B MLST8 HEL-S-28 EIF4E TNLG5A RPS6KB1 IGFBP5 PRKAB1 AKT1S1 MAP1LC3A TRIM63 PTEN EIF2B2 FBXO32 PPARGC1A RICTOR GDF8 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR STAT3 ROCK1 PLCG1 BDNF PIK3CA SHC1 NTRK2 GABRG2 ARHA PIK3R2 PIK3R1 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 CREM GABRE GABRQ GABRA2 GABRP SLC12A5 PIK3R3 GABRA6 PTEN GABRA5 GABRA4 GABRA3 CREB1 GABRG3 GABRG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PLCB4 POMC PLCB1 PLCB2 ARRB2 GPR143 PRKACG VEGFA PRKCB DCT GNA15 PLCB3 CREB1 ADCY9 PMEL ASIP GNAS TYRP1 TYR MC1R FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 APOB NR1C1 ACADM HADHB PPARGC1B STK11 ESRRA ACLY MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation GSK3B SPRED1 MAP1B MARK1 TAOK1 PHLDB2 MAPRE1 F2RL2 PAK1 STAT3 RHO ROCK1 SRC PARD6A CLASP1 NTRK2 LIMK1 APC CDC42 EPHB2 DVL1 AURKB NTRK1 PRKCA PTEN NTRK3 RAC1 CFL2 WNT3A CDC2 FREP1 TIAM1 MAPKAPK2 TRIO CAMK4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 RORC EBP AKR1D1 INSIG1 AKR1C4 CYP46A1 THEM5 DHCR7 HSD3B7 GPR183 ACOT8 LBP ACOT7 NR1H2 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 SULT2B1 CH25H AMACR ACOT6 SLC27A2 ACOT4 CYP3A4 DBP CYP7A1 NR3A2 EPHX2 CYP27A1 NR1i2 CYP8B1 SLC27A5 SULT2A1 IL25 ACOT9 IL17F IL17D IL17C IL17B IL17A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR SPHK2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation STX1A TDO2 TSC2 TPH2 ACHE TGFB1I1 TNF HRH3 NECTIN2 MAPK14 ADORA2A SLC5A7 ITGB3 SLC6A3 TNFRSF11B TH RBL2 UNC13B IL1R1 FBXO32 AMPH IL1B SLC6A1 SLC6A2 SYN1 DBH ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR SLIT2 RAC1 ROBO4 VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 ESD PON1 LIPA HEL126 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL1 LOXL2 LOX SMAD2 SMAD4 MAPK9 BMP1 MAPK8 TGFB1 GREM1 TGFBR1 BMPR1A BMPR2 MAPK14 TGFBR2 LOXL4 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GOT2 GAD2 AGXT ASPA ASS1 GAD1 GPT PC ABAT MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 PMVK MVD ACAT2 HMGCR FDPS SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 DLL3 MESP2 LFNG HES7 EPHA4 RIPPLY2 TBX6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 DHCR7 LBR HMGCR NR1H2 CH25H FDFT1 SQLE SOAT1 FADS2 SCD CYP27A1 FADS1 MYLIP ELOVL5 FASN ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK SREBF2 HMGCS1 SOAT2 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 FACL4 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP1 HDAC2 RBX1 STAT1 STAT3 HDAC3 DTX3L BTRC SKP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling SMO SUFU DHH PTCH2 SAP18 KIF7 SIN3A PTCH1 IHH GLI3 ADRBK1 SHH ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 IFNAR1 TNF ACE2 IFNA1 TNFRSF1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS5 PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN2A CCND2 SMAD4 BAK1 INSR NRAS MAP3K1 WNT7B WNT7A SHC1 CTNNB1 HMGB1 MYC AKT3 IRS1 ERBB2 MAPK1 SOS2 KRAS WNT5B BCL2L11 BCL2 LDLR CDKN1B BBC3 LEF1 TNFSF6 CCND3 RAC3 MAP3K7 RBL2 DVL1 PIK3R3 DVL2 TCF7L2 DVL3 TCF7L1 NFKB2 PMAIP1 WNT1 WNT3 MLKL WNT4 G6PC1 PCK2 WNT3A CCNG2 CCND1 GSK3B WNT2B PIK3CD MAPK10 MAPK9 MAPK8 TGFB1 TP73 BCL6 BAX AXIN1 FRAT1 WNT16 JUN PIK3CA NFKB1 ARHA BAD BIK PIK3R4 APC PIK3R2 PIK3R1 CDC42 PIK3R5 FOSL1 PIK3C2G FOXO3A WNT10B PIK3C2A WNT10A MDM2 PIK3C2B ATM PPP2R5E CDKN1A PTEN PPP2R5C RAC1 HRAS GRB2 SOS1 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing TLR4 MMP9 FST KLF4 TNC INHBA FGFR4 VEGFA SNAI2 HMGB1 HGF ACHE TNF CCL2 COL1A2 BCL2 EGF CHRNA7 CXCR4 FGFR2 FBN1 F13A1 PECAM1 FOXE1 HEXD DKFZp686P11128 DCN TIMP1 KRT6A KRT222 FLG IL15 PCTK1 SCEL HEL-S-43 COL1A1 AMBP SLURP1 MYD88 CASP3 LIN28A CD3E CXCL12 TPT1 BAX NFKB1 IL6 CXCL8 S100A6 IFNA2 BRD4 FGFR1 S100A9 NOX4 MMP28 ACTA1 IL8RB IFNB1 MMP2 IL1B CXCL1 FGFR3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p C7orf24 OPLAH GCLC HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 CDK7 RUVBL1 GTF2H2C_2 KARS1 CCNH GTF2H2 JUN GTF2H3 GTF2H5 SH3RF1 FOS NFKB1 HINT1 ERCC2 TCF4 RUVBL2 CTNNB1 MNAT1 NFATC2 USF2 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 AKR1C4 AKR1C2 CYP3A4 CYP1B1 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA ERI1 AGO2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 MAP4K1 MAP4K2 WWTR1 MINK1 YAP1 MAP4K3 RASSF1 LATS1 TEAD4 LATS2 STK38L TNIK TEAD2 TEAD3 HEL-S-31 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 MAPK8 TNFSF11 ITGB3 TRPV5 TNFRSF11B CTSK TNFRSF11A IFNAR1 IFNB1 SPP1 GPR68 AIMP2 ACP5 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB1 CACNB1 CDH2 SGCA CTNNB1 DMD CACNG1 CTNNA1 SLC8A1 CTNNA3 CTNNA2 ACTG1 tmp_locus_29 CACNA2D1 ITGB3 GJA1 LEF1 CACNA1C ITGA2B CACNA1F LMNA EMD TCF7L2 TCF7L1 ITGA1 CACNB3 CACNA1S ITGA2 ITGA4 DAG1 ITGB7 PKP2 JUP ACTN2 ACTN1 ACTN4 CACNA2D3 CACNA2D2 CACNA2D4 RYR2 CACNB4 ATP2A2 DSG2 DSC2 CACNG6 CACNG7 ITGB5 CACNG8 ITGB4 CACNG2 CACNG3 PS1TP5BP1 CACNG4 CACNG5 ITGB8 ITGAV ITGB6 SGCD SGCB SGCG ITGA7 ITGA6 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GSK3B PIK3CD TSC2 TSC1 NRAS UBE3A BDNF GRIN1 PIK3CA ARC NTRK2 DLG4 AKT3 PRKAA2 EIF4EBP1 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 PRKAA1 GRIN3B GRIN3A NF1 CACNA1C PRKAB2 SHANK3 RPS6KB1 RHEB PRKAB1 GRIN2B PIK3R3 SYNGAP1 PTEN HRAS HOMER1 CAMK4 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MEF2C ARAF NRAS BRAF GAB2 CRK MAP3K2 VAV1 SRC PIK3CA SHC1 AKT3 MAPK1 KRAS CRKL MAPK3 SHC4 INPP5D ATF2 SHC2 MAPK11 SHC3 MAPK14 BCR PIK3R1 BCL2 EIF4B HSPB2-C11orf52 BCLAF1 BCL9 RAF1 CBL RPS6KA1 SPAG1 PXN DOK1 HEL-S-102 HRAS GRB2 SOS1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 ANGPT2 PRKD3 PPP3R2 PRKCZ RCAN1 PRKCH PKN3 PKN2 PRKCB PKN1 NFATC1 PRKCE PRKCA PLCB3 PPP3CA PPP3CC PRKD2 PRKCI PRKCQ PRKD1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling IFITM3 CEBPB CCL8 RPTOR CCL4 LARP1 CCL1 DEPTOR MLST8 VPS11 EIF4E VPS16 CCL15 VPS18 GABARAPL2 VPS33A RPS6 RHEB AKT1S1 VPS41 HIF1A AHR LCK IF2B1 TF CD3G IL-21 CD3E CXCL12 IL18RAP PIAS1 IL10 IL13 IL4 IL5 RRAS CXCL8 APOC1 SMAD1 ULK1 SIGMAR1 IL9 HEL117 MMP25 IFIT1 GTSE1 VPS36 WDR74 CD226 TRPM2 APOH APOD RAC1 HEL103 JAK1 INTS4 HRG CXCL13 CTSZ TGFBR2 SERPINA10 SDF2 CCR6 IL1A TOMM70 GP1BA IL16 HMFT1766 IFI6 OS9 PTGS2 MIB1 STAT1 SRP19 HEL-S-81p HP IFI44L CLCC1 TLE3 GTF2F2 UGCGL2 G3BP2 CXCL6 NLRP1 DKFZp781O1323 NPTX1 MDN1 IFITM1 FAM83A CXCL3 NEK9 IL7 CD163 TP53I3 LGALS3BP TNF TRO TRIM59 BST2 ITIH3 ATE1 IFI27 MX1 CCL20 TBKBP1 ATP13A3 IL33 FAM98A CCL22 CCL21 HBB CCL27 PF4 CCL26 DDIT4 RTN4 FGA HEL-S-78p NFKB2 ALB SAA1 SAA2 IRAK1 CASP9 MYD88 CASP3 TRAF2 TRAF6 SRP54 HBD CXCL5 MTOR TPO FGF2 PMPCB IFNB1 ADAM9 IL1R2 CXCL9 PITRM1 CXCL1 CCL3 NLRP3 HEL-S-130P CXCL2 CRP RRM2 GGH CCL11 ZAP70 CARD11 CCL5 EIF4EBP1 HLA-DRA NFATC3 FYN CCL2 APOA2 PTPN6 OAS2 IRF9 C8A IL12A C1QBP CCNB2 IFNG CCNB1 CDC2 IL17A HLA-DRB5 NRF CD8B1 MAPK8 PRG3 CD2 CFH IGLL1 CD8A CFI LBP CFP CTSL CPN1 CASP8 PARP2 C1R SELP HEL-S-72p EGR1 IFIH1 IRF3 CD14 BIRC5 ITIH4 TRAF3 HLA-DRB1 APOL1 ACE2 CASP5 COQ8B ACTG1 TNFSF10 STEAP3 JUNB NTRK1 PRKCQ MOV10 DKFZp762B153 TBK1 IKBKG JUN IL6 CCR5 MAVS RIGI EIF4A2 PS1TP5BP1 CXCL16 FOS IL8RB IL18 IL1B CXCR1 ITCH CAMK4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling GSK3B RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 CEBPD CTNNB1 SPP1 APC CSNK1A1L TOR1AIP1 SLC2A4 CDK6 PPARG WNT10B LEF1 ZMPSTE24 FNTA LMNA HES1 EMD HES5 TCF7L2 TCF7L1 ICMT HMGA2 DICER1 TARBP2 CCND1 AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 SMARCC1 SMARCA4 MBD5 NCOA6 SMARCD2 ARID1A PAXIP1 SMARCC2 SMARCD3 KMT2C ACTL6B DPY30 ARID1B PAGR1 ASXL1 WDR5 BAP1 ACTL6A EHMT1 ASH2L H3F3B RXRA NR1I3 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways OSTM1 PLEKHM1 NFKB1 SNX10 TNFSF11 IKBKB TCIRG1 TRAF6 RAB7A TNFRSF11A CLCN7 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 CYP24A1 AGTR2 REN KLKB1 ROCK1 NFKB1 CPN1 KLNA1 BDKRB2 CYP3A4 PRKG1 IL1B MAPK1 NR1i1 TNF ARHA BDKRB1 ACE2 AGTR1 IL1A SERPING1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome USP9X PDE6D BBIP1 DYNC2I2 INVS NPHP3 DYNC2H1 CRX DYNLT2B TRAF3IP1 SUFU CEP164 FLCN DYNC2LI1 IFT52 KIF7 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 OCRL CEP290 SCAPER ZIC2 BBS4 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK IFT172 TMEM216 EFHC1 WDPCP EFHC2 IFT74 CNGB1 SDCCAG8 PKD1 CEP104 ARL6 ARL3 PKD1L1 PKHD1 PTCH1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 PCARE SMO SCLT1 DCDC2 IFT81 FUZ TTC8 GPR161 MKS1 CEP41 IFT27 TRIM32 GLI3 CLUAP1 RAB23 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1A2 NAA50 CYP2J2 GATF-C CYP21A2 GLYATL2 AKR1D1 CYP4F11 AKR1C4 CYP46A1 CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 LOC51064 CYP7B1 SULT2B1 HS2ST1 SULT1C3 CYP26B1 CYP4V2 HYAL3 CYP2C19 UGT2A2 CYP3A7 UGT2A1 CYP3A4 GAL3ST2 CYP2W1 GAL3ST3 SULT1C4 CHST8 HS3ST3B1 CHST9 EPHX2 CHST6 CHST7 CYP2R1 CYP3A43 KCNAB1 KCNAB3 CYP2A7 CYP26C1 CHST1 CHST4 CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 CYP17A1 CYP2A13 UGT1A5 AKR1B1 CYP2F1 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 GSTZ1 CYP20A1 CYP4F2 CYP4F12 HEL-S-165mP EPHX1 CYP7A1 CYP11A1 MGST1 GSTT2 UGT1A3 SULT2A1 CYP1A2 CYP1B1 MGST3 GPX3 MGST2 CYP1A1 CYP2E1 GSTM3 NNMT TPMT INMT GSTM5 CYP4F8 CYP2C8 UGT2B4 UGT2B7 NAT2 CYP2S1 GSTM1 SULT1A1 SULT1E1 BAAT CYP27B1 SULT1C2 CYP11B2 HEL-75 CYP27A1 GSTM2 CYP8B1 GSTA5 CYP2C9 GSTA4 CYP2A6 GSTA3 UGT1A10 CYP2B6 UGT1A1 UGT1A9 HEL-S-64p HS3ST2 GSTM4 GPX4 CYP51A1 CYP24A1 GPX2 HEL-S-22 UGT1A4 UGT1A7 AKR1C1 AKR1C2 HEL-S-75 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 HEL-S-21 HEL-S-166mP UGT2B11 GAL3ST4 UGT2B15 UGT2B17 CYP2U1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP2C18 CHST13 CHST14 NAT8L GSTT2B SULT1A4 CYP4F3 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CDKN2A EGFR MAPK8 BAK1 BAX TRAF2 TRAF6 JUN TNFRSF1A FAS PDGFRA IL2 IL6 MAP2K3 HBEGF MAP2K4 TNF MAPK12 BMF MAP2K6 MAPK13 MAP3K5 ATF2 FGF7 MAPK11 MAPK14 BCL2L11 BCL2L1 BCL2 NFE2L2 TNFSF10 TNFSF6 CCNE1 JUNB FOS CCNA2 CDKN1A IFNG RB1 MMP2 MCL1 CCND1 TRAF5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 ATG3 TSC2 INSR TSC1 ATG12 ATG16L1 INS ATG14 MAP1LC3A ATG5 AMBRA1 SH3GLB1 CHAF1A UVRAG ATG9B ATG10 ULK2 VMP1 ULK1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 GCK ACSS1 MTTP LMF1 LDLR PLTP GPIHBP1 LPL FAS PDIA2 APOA5 APOC2 LIPC GCKR DGAT2 APOA2 SEL1L COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SGOL1 PTTG1 ESCO1 ESCO2 REC8 SMC1B MAU2 STAG2 SMC3 STAG3 ESPL1 WAPAL HDAC8 APC PLK1 PDS5B PDS5A PPP2R1B RAD21 PPP2R1A PPP2R5E SMC1A PPP2R5B PPP2R5A AURKB PPP2R5D PPP2R5C PTPA PPP2CA CDC2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation PDLIM7 SLC34A1 FGFR4 PFN3 IGF1R CAPN3 SRC GRIN1 MYC KDM6B HEL-S-273 COX2 GPRIN1 ARL10 H2AX CXCR4 ADAM10 PTH FGF8A TMED10 HK3 NTN1 COX1 MAPK10 MAPK9 MAPK8 GNAI1 RNP24 PLCG1 PRR7 EIF4E1B GNAI3 JUN COX7B KIAA1191 COX4I1 FAF2 MAX CLTB DDX41 TRIAP1 COX6A1 BABAM1 BABAM2 BARD1 UIMC1 COX8A EED INPP5D TMED9 RNF44 CYP7A1 UNC5A MYO7B PNPLA2 COX6B1 PIK3R1 ARFGAP2 FBXW7 HIC2 DOK3 CDHR2 FAM193B DBN1 ABRAXAS1 USH1C BRCC3 COX7A1 LMAN2 MAGED1 RAB24 COX7C COX3 ZNF346 SNCB PRELID1 PTPRN2 NELFB NOP16 GRIN2B MUPCDH COX5A HIGD2A TSPAN17 BRCA1 DRD2 SNCA ANKS4B H3F3B MXD3 FRS2 ABHD5 GRB2 SOS1 RGS14 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis DHRS7B AGMO AGPS LPIN1 LPIN2 LPIN3 CEPT1 FAR1 UGT8 PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L PEX3 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation MIXL1 ITGB1 KLF4 CNP HOMER3 MBP FOXD3 MSX2 PAX3 MOG S100B OLIG2 SOX10 GFAP ACHE TWIST1 GATA4 NEFL MSX1 LHX1 GAD2 NR2A1 TPM1 GAD1 GATA6 MAP2 TWIST2 DLG4 CLDN11 ERAS CASK CACNG2 ROBO1 SHANK3 GRIN2B SLC6A5 SLC6A9 DLG2 SHANK1 SLC6A1 SLC6A2 HOMER1 TNC AQP4 RIMS2 BSN CDH2 RBFOX3 FBXO15 TBR1 SNAI1 ZFP42 SNAI2 LIN7A BMP4 FUT4 POU5F1 TPH1 ChAT HOMER2 GRIN1 FEV CD24 NEF3 PCLO ERC1 SLC1A2 CD34 PAX6 ADRA2C ADRA2B ADRA2A DPPA3 DPPA2 SOX2 DCX TBXT GLRA1 GLRA2 LMX1B GLRA3 NOTCH1 GABBR1 HTR5A GLRB RIMBP2 NLGN1 5HT1A CSPG4 FOXA2 SLC6A3 LEF1 HES1 ESRRB HES5 PECAM1 GLS NGFR SOX17 PIG59 GPHN GABBR2 KCNJ6 SNAP25 SOX9 SLC1A3 NODAL AP2A1 AP2A2 TH SLC17A6 SLC17A7 FGF7A SLC18A3 HES3 UNC13A ITGA6 SYP CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 ADCY1 MAPK9 MAPK8 DAGLA CYP2C19 CYP3A4 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 ADORA2A FAAH CYP2C9 CNR2 NAPEPLD DAGLB PRKACG CYP1A1 PRKAR1B CNR1 PRKAR1A AHR TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R5 PIK3CD EGFR RAF1 PIK3C2G PIK3C2A PIK3C2B NRAS PIK3CA PIK3R3 AKT3 ERBB2 MAPK1 ERBB4 KRAS MAPK3 HRAS PIK3R4 PIK3R2 PIK3R1 ERBB3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IF2B1 IL15 RORC RORA ID2 TBX21 IL13 GATA3 TOX IL4 IL6 IL5 IL7 TNF IL33 ZBTB16 HNF1A TSLP IL9 IL25 GFI1 ATL1 NFIL3 IL12B IL12A IL18 IFNG IL23A IL1B AHR IL17A AREG MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TAOK1 CACNB1 LAMTOR3 RRAS2 CACNG1 SOS2 EGF FGFR2 PRKACG PLA2G4B ARAF CDC25B NFATC1 MAX RASGRP3 RAP1A RRAS DDIT3 CRKL GADD45A CACNA2D3 CACNA2D2 PPP3R1 CACNA2D4 PPP3R2 CACNB4 CACNG6 CACNG7 CACNG8 NF1 CACNG2 CACNG3 CACNG4 CACNG5 MAP3K13 IKBKB PPP3CA RAC1 PPP3CC HRAS TGFBR2 IL1A EGFR NTF4 PAK1 RELA FGFR4 NRAS MAP3K1 MAP3K7IP1 FAS FGF10 RPS6KA3 MAP2K3 MAP2K4 TNF MAPK12 MAP2K6 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K11 SMIM40 RAF1 TNFSF6 CACNA1C CACNA1F FGF8A NFKB2 IL1R1 CACNA1S FGF6B MAPKAPK2 MAP2K5 CASP3 CHUK TRAF2 TRAF6 CRK TNFRSF1A MAPK7 NTRK2 NLK FGF20 FGF22 FGF7 FGF21 FGF8 DUSP4 FGF9 FGF16 FGF14 FLNB CDC42 FGF13 TAOK2 FGF18 FGF12 FGFR1 FGF2 FGF7B FGF7A DUSP2 NGF FGF5C IL1R2 GRB2 SOS1 FGFR3 MEF2C BDNF FLNA NFATC3 STK4 RPS6KA4 RPS6KA5 RAC3 MAP3K8 MAP3K6 MAP3K7 MAP3K12 HEL-S-31 MAPK10 MAP4K1 MAPK9 MAP4K2 MAPK8 TGFB1 MAP4K3 MAP3K2 HEL-S-103 HEL-S-72p RASGRF1 MAPKAPK5 HSPA2 PLA2G4F CD14 FGF23 PLA2G4D PLA2G4E PLA2G4C PDGFA BRAF TGFBR1 MYC AKT3 JUND MAPK1 DUSP10 KRAS MAPK3 ATF2 CACNA2D1 LRRK2 MAPK8IP3 MAPK8IP1 ECSIT DUSP3 DUSP8 DUSP9 DUSP7 PRKCA RAPGEF2 NTRK1 NTF3 TAOK3 CACNB3 RASGRP4 CACNA1H CACNA1G CACNA1I HEL-S-102 RASGRF2 DUSP16 PPM1B RASA2 pk ATF4 PPP5C MAPK8IP2 RELB IKBKG JUN GNG12 MAPKAPK3 NFKB1 MAP3K14 CACNA1B CACNA1A ARRB2 FOS IL1B PTPN5 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABBR2 GABRG2 SLC6A11 GABBR1 GAD2 AP2A1 GAD1 AP2A2 GABRB3 GABRB2 ABAT AP2S1 GABRB1 GABRE GABRQ GABRA2 GABRP AP2M1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 SLC6A1 GABRG1 SLC32A1 ALDH9A1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HEL25 CBX3 MBD2 CBX1 CHD4 HDAC2 CHD3 MTA2 H3C8 RBBP7 MTA3 MBD3 HDAC1 LEF1 SUV39H1 KDM1A H3C15 RB1 H3F3B RBBP4 KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome TMEM98 GNRH1 NEUROG1 FGFR1 SEMA3E ASCL1 OTX2 ANOS1 PIK3CA PLXND1 OLIG2 PROK2 SOX10 MYRF FRS2 MAPK1 LHB PTPN11 FGF8 GRB2 MAP2K2 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma DKFZp762B153 NFE2L2 STAT3 TFEB MDM2 IPO8 PINK1 AGER PARK2 NFKB1 HMGB1 SQSTM1 KRAS VMP1 SHOC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP2C8 FADS1 ELOVL5 ALOX12 LTC4S PTGS2 CYP2C9 HEL-S-22 ALOX5 ALOX15B CYP1A2 ALOX15 HPGD GPR32 FPR2 CYP2E1 PTGS1 PTGIS CYP3A4 GSTM4 FADS2 EPHX2 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 RPS6KA5 BRAF HTR4 HTR6 HTR7 RAP1A CREB1 MAPK1 EGR1 MAPK3 ATF1 GNAS MAP2K1 MAP2K2 MAPKAPK2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome AFDN F11R GJA3 GJA5 ACP6 CTNNB1 GJA8 AMELX NBPF12 CHD1L PRKAA2 PYGO2 TJP3 PRKAG1 PRKAG2 PYGO1 BCL9 PRKAG3 PRKAA1 GJA1 KIRREL1 PRKAB2 PRKAB1 FMO5 TJP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex HIST1H2BE HAT1 ASF1A CREBBP ASF1B HDAC2 EP300 MBD3 EP400 MAPK3 H2BC21 H2AX HDAC1 TLK2 RBBP4 KAT2B MBD2 CHD4 CHD3 MTA2 H3C8 H3C15 PWWP2B UBTF PWWP2A TBP SIRT7 POLR1A POLR1C POLR1D RRN3 SRCAP TAF1D H2AC19 TAF1B H2AB1 TAF12 H2AC14 GATAD2B H2BC26 GATAD2A H2BC12L CDK2AP1 HIST1H2AB H2BC9 KAT2A H2AZ1 H2AZ2 H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 H2BC1 H2BC17 H3F3B H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2AC20 H2BC11 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PLA2G1B PTDSS2 PTDSS1 CHKB PCYT2 ETNK1 GPAM PEMT CDS1 CHPT1 CRLS1 PISD AGPAT4 GPAT4 PNPLA3 DGKZ DGAT1 DGAT2 CDIPT PNPLA2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP EPHX1 CYP3A4 CYP1A2 GSTM1 CYP2A13 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle MCM5 MCM6 TTK CDKN2A CCND2 FZR1 HDAC2 CDC45 WEE2 EP300 CDKN1B CCND3 E2F2 ANAPC1 SMC1A CCNA2 CCNE2 CCNB3 CCNB2 RB1 CCNB1 GADD45B CDC2 GADD45G CCND1 CHEK2 CHEK1 PTTG1 TGFB1 SMC1B CDC25B STAG2 CCNH SMC3 CDC27 ESPL1 E2F4 GADD45A PLK1 TFDP2 MCM2 RAD21 CDK7 MAD2L2 STAG1 MDM2 CCNE1 ATM ATR CDC20 SMAD2 SMAD4 WEE1 CDK4 MYC CDK2 HEL2 HDAC1 RBL2 RBL1 TFDP1 CDKN2D CDKN2B E2F5 CDKN2C GSK3B SFN CDKN1C SKP1 RBX1 PRKDC PCNA CDK6 E2F3 YWHAQ HEL-S-1 CDC14B YWHAG CDC23 PTTG2 SKP2 ANAPC7 ANAPC5 YWHAZ MAD1L1 ANAPC2 CDKN1A ANAPC13 PKMYT1 ANAPC11 ORC6 ORC3 ORC2 CDC6 MCM7 ORC1L DBF4 MCM3 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23 HEL-S-310 RPS6KA2 RPL4 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPS15 FAU RPS14 RPL13A RPL7A RPS6KA3 RPS17 RPS16 RPS18 RPL36 RPL35 RPL38 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPS6KB2 RPL5 RPL22 RPS3A RPL30 RPL7 RPSA RPS6KA6 RPL18A RPS6 RPL37A RPL29 RPL28 RPL10 RPL12 RPS11 MRPL19 RPS6KB1 RPL36A RPS4Y1 RPS15A RPL14 RPS19 RPS3 RPS27A RPL13 RPS2 RPL11 RPL15 RPL18 RPL17 RPL19 RPL27 RPL41 RPL35A RPL26 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP2 RPL10A RPS6KA1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation HDAC10 FHL2 LDB2 PAX3 SOCS2 DMD HDAC6 FYN CCL2 CDON PRKAG2 ZBTB16 LHX1 CTNNA2 FGFR2 MAFB POU2F2 ELOVL4 GATA6 NR1C2 TCF3 NUMA1 CDH8 SDCBP GAS2L1 KRT6A RGMA NF2 CTNND2 ARHGDIG KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E ARX STC1 NFATC1 ARHGAP15 ZBTB2 JUP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B TFAP2C SMURF1 GREB1 NR2F2 CLDN11 PAN2 PTPRB PPFIBP2 SCHIP1 HMGB2 WDR44 SIX6 AHI-1 BOC RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 FZD5 ARHGEF9 BMPR1A KIFC3 RUTBC3 STX16 FZD8 RRBP1 TBL1X CLVS1 TTC14 TNLG7C SNCA C1GALT1 TRPM2 VAX2 RIT1 GLB1 ZNF219 BCOR SKIL MYORG ELOVL2 SMAD4 CDH6 OGT BMP4 SHH CTNNB1 MYC PAX6 TFAP2A SOX2 CAP2 PDE7A NLGN1 FOXA2 TNFRSF11B TCF7L1 WNT1 SPRY2 CELSR2 NLK UBTF ZFHX4 PTPN13 PIM1 CTBP1 FZD4 MKS1 GLI3 H2BC9 TOX3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway GALNT9 MAMDC2 ATP1B2 MID1 ERAF CRTC2 SPINT1 PAK1 C1QTNF12 EPOR EP300 FAM20C RELA SPIRE1 ARHGEF7 SFI1 IFI44L ATP10D TSPAN33 RHD CAMK1 ENHO CYB5R3 TSPAN8 SLC25A21 NLRP1 KDR FIS1 STIM1 SLC38A5 WFS1 KLF1 LR8 SLCO3A1 CCL5 TRPV4 CPOX MAPK1 RHAG TNF MAPK3 NFATC2 HFE RPTOR TBXT SLC2A4 ACACA RAF1 FASN NFE2L2 RPS6 SIRT1 ABCA1 RPS6KB1 SMC1A MAP1LC3A SQSTM1 HIF1A CAMKK2 PCK2 CCND1 MX2 KEAP1 VCAM1 GCK IL15 HMBS DKFZp762B153 CHRM3 TSC1 WDR35 DGIC HMOX1 PFKFB2 HK2 ULK1 MTOR CALM1 SELL PARP1 ASNS CCNE1 S100A8 AQP1 CREB1 RAC1 MAF MS4A3 CXCL11 IFGGE OASL ERMAP CAMK4 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CHRNB4 CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA EGFR PTEN RPL11 AKT3 FOXO3A MAPKAP1 RICTOR RIOK2 RIOK1 MTOR MLST8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 MAVS RIGI IFIH1 MR1 IRF3 TLR8 TLR7 TNFRSF11A TLR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion GNA11 PLCH1 PLCD3 PLCB1 PLCB2 PLCB3 PKD1 PLCG2 PLCG1 PLCL1 PLCE1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 ARID5B TBX1 UCP1 PRDM16 PPARGC1A IRX5 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC RBX1 CBFB CUL5 UBB RUNX1 APOBEC3G NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B3GNT5 NEU2 FUT5 B4GALT1 FUCA1 FUT1 NAGA FUT2 SIAT4C B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NFE2L2 TGFB1 NQO1 SIRT1 CDC37 EXOC6 ECSIT DDR1 SUV39H1 NRF1 HEL-S-7 PKD1 COL2A1 FGF7 BMP2 IGFBP7 LOXL4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC1A RAD21 RAD18 PAXIP1 BRCA1 MRE11A MDC1 ATM SMC3 NBN RAD50 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELE TLR4 SELP TGFB1 SELPLG PF4 CD40 CD40LG CCL5 IL1B CCL2 TLR7 VCAM1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism CD36 STAR PBR LIPC LIPA APOA2 CYP27A1 PCSK9 APOA4 SCARB1 MTTP APOB LDLR MYLIP PLTP ACAT2 LPL HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK LIPG MVD NPC1 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 CIDEB FABP2 VAPA EBP CYP51A1 SC5D DHCR24 DHCR7 LBR LPA HMGCR FDFT1 DGAT1 SORT1 SQLE APOC2 SOAT1 APOC3 ABCG8 APOC1 ABCG5 CYP7A1 APOE ABCB11 APOH STARD3 NPC1L1 NPC2 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DROSHA MRE11A ATM NBN RAD50 DDX1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 NFE2L2 SLC3A2 SLC7A5 KEAP1 ATF4 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling HHIP SPOP CSNK1G3 CCND2 SMURF2 FBXL17 SPOPL CSNK1D GAS1 CSNK1G2 CSNK1G1 EVC ADRBK1 CSNK1A1 SHH CSNK1E DHH IHH SMURF1 PTCH1 CDON EVC2 CSNK1A1L BCL2 SMO BOC ARRB2 GPR161 GLI3 PRKACG SUFU PTCH2 KIF3A KIF7 CCND1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL5 ACE2 FADS2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PHGDH PSAT1 PSPH ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling RELA STAT1 CEBPB VEGFA SRC TYK2 SHC1 SOCS3 IRS1 CDK2 MAPK1 JUND KRAS MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 IL6ST RAF1 CDKN1B RPS6 PRKCH PRKCB PXN JUNB PRKCE PRKCA OSMR HIF1A STAT5B PTK2B JAK3 OSM MAPK9 MAPK8 CASP3 STAT3 NFKB1 MTOR PIK3R1 FOS CREB1 JAK1 RICTOR EGR1 HRAS GRB2 SOS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 MAPK1 RYR3 ITGB3 MFAP5 MAPK3 TNNC1 PRKCQ PLCG1 JUN ITGAV GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis NOTCH1 MESP2 LFNG HES7 EPHA4 RIPPLY2 WNT3A FGF8 TBX6 HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC1H1 DCTN1 ADCY3 RAB11B DYNC1LI2 DNCL1 ADCY6 AQP4 ARHGDIG DCTN6 DCTN5 DYNC1I1 RAB5B DCTN4 HEL-S-47e HEL-S-77 AQP2 AQP3 ARHGDIB AVPR2 DYNC1LI1 RAB11A GNAS RAB5A DYNC2H1 CREB3L3 AVP CREB3L4 PRKACG DYNLL2 CREB3L2 CREB3 RAB5C DYNC2LI1 CREB1 ADCY9 STX4A CREB5 VAMP2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling BCL2 MAPK9 CHUK GNGT1 BRAF IKBKG JUN PIK3CA FOS NFKB1 SP1 GPER IKBKB CREB1 MAPK1 GNB1 GNAS MAP2K1 MAPK14 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle INS SLC2A4 HEL-S-68p PGAM1 HEL-S-133P PFKP GPT HEL-S-49 HEL-S-87p HEL-S-162eP SLC2A2 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK1 TLR4 IRAK4 MYD88 TRAF6 AGER NFKB1 TREM1 IL6 IFNB1 CXCL8 IL1B MAPK1 TNF HEL110 IFNA1 CD14 IL1A TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 SMAD4 WWTR1 SPARC TGFBR3 POSTN CTGF TGFBR2 TGFBR1 YWHAG RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling AFDN GNG3 GNG2 GNG5 GNG4 GAB2 GNG7 GNG8 ZAP70 KDR SHC1 KSR1 PDGFRA RRAS2 PLA2G2A SOS2 MET SHC4 LAT SHC2 PTPN11 SHC3 STK4 FLT3 FGFR2 PRKACG RAC3 PLA2G5 PLA2G6 PIK3R3 RAB5C PLA2G4B PAK6 PAK4 MAPK10 MAPK9 MAPK8 CALML6 CALML3 ARF6 CALML4 EXOC2 HTR7 RASGRP3 RAP1A RRAS PIK3R2 PIK3R1 RASGRF1 NF1 GRIN2B SYNGAP1 IKBKB ABL2 RAC1 HRAS KSR2 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D RALA PLA2G1B PLA2G4E PLA2G4C PLA2G3 EGFR PLA2G10 PAK1 FLT1 INSR RELA FGFR4 NRAS IGF1R GRIN1 RASSF1 AKT3 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAB5A BCL2L1 ETS2 RAF1 TNFSF6 EPHA2 PRKCB GNG10 GNGT2 PRKCA NTRK1 RASGRP4 KIT REL RASGRF2 TIAM1 RASA2 PIK3CD NGFR CHUK PLCG2 PLCG1 IKBKG RAB5B GNG12 GNG11 PIK3CA NFKB1 GNG13 CSF1R NTRK2 GNB2 ARHA GNB1 BAD PLA1A GNB4 RASAL1 GNB3 RASAL3 PLCE1 TTBK1 GNB5 RASA4B RALBP1 CALM1 PLAAT3 CDC42 RASA3 RASA4 RIN1 RAPGEF5 PLA2G2F PLA2G2E FGFR1 PLA2G2C FOXO4 PLD2 GNGT1 FLT4 RALB GRB2 SHOC2 SOS1 FGFR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CHST7 EXT1 CHST1 CHPF CHST3 XYLT2 XYLT1 EXTL2 HS6ST1 EXTL1 HS6ST2 CHSY1 HS6ST3 CHSY3 CSGALNACT1 NDST3 CHPF2 B3GAT3 GLCE B3GAT2 B3GAT1 CSGALNACT2 B3GALT6 HS3ST1 HS3ST3A1 EXT2 UST CHST11 CHST12 HS3ST2 CHST13 CHST14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 SMAD2 CASP9 CASP3 STAT1 BAX MRE11A CDC25B MSH6 RAD50 MSH2 BLM CDK4 MYC CDK2 CASP8 BARD1 ATF1 MAP3K5 BAD PLK1 BCL2 CDKN1B BBC3 NOXA1 MDM2 ATM ATR POU2F1 BACH1 CDKN1A PTEN BRCA1 RB1 JAK1 CDKN2B CDC2 CHEK2 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell SPRYD4 AP3D1 PHLDB2 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 LAMTOR3 LAMTOR5 TUSC2 LTN1 CPOX ARID4B CALCOCO2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ERBB3 POGLUT3 VPS39 KPNA3 EIF4E AXL MYLIP TPM3 TPM1 GRIA2 STX7 UBE4A ATG9A CDKAL1 RAB30 GPD2 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP MCL1 CCND1 CD164 BRPF3 HMGA1 SLC4A10 NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 CHMP2A SRPRB DKFZp761E1322 PICALM SLC25A1 DOCK5 TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 HSDL1 DSG2 ARID1A TXN2 RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 NXN UHRF1 HSD17B12 GNA13 DNAJB1 CAND1 PPP3CA POLR2C TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 CSF1 IRS1 MAPK12 MAPK14 PPIF MTRR LPL RTN4 KIT PRKCI COL3A1 DOCK7 RARS1 HEL-S-47e MAPK7 CDK6 E2F3 ITGB4 LAMC2 FGF2 P4HA2 NELFCD CDKN1A TMEM87A VSNL1 FSTL1 CA12 CAMTA1 ACVR1B PPIB HYAL3 ERBB2 CDKN1B LAMC1 C1QBP TNFRSF10B ITGA2 CCNG1 SNAP23 PTPRF COL1A1 SPARC SYPL1 THBS1 GPAM CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 GFPT1 ERG ATP6V0E1 CPNE8 VEZT TMEM41B EHMT1 SLC38A5 CLDN1 PWP1 ABCG2 KRAS CHORDC1 RAVER2 COL1A2 CIAO2A SEC62 NOTCH2 CDK5RAP3 NOTCH1 BCL2 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B GJA1 FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 HES1 HACD3 MRPL20 SLC7A11 BACH1 COMMD9 RDH10 GRPEL2 SNX6 SLC38A1 GSTM4 RAB27B MOV10 POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B RNP24 NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MRC2 PANX1 COIL SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC MRPS24 ATP2A2 ELMOD2 TMT1A AP3B1 SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN SSNA1 AMIGO2 NAPG HEL-S-66 PTPA NT5E PGRMC1 PPP1R7 USP1 SHOC2 SRSF10 MPZL1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS IL12A VIP IL2 IL4 IL5 IFNG TGFB1 CD80 IL10 CTLA4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 POMC CDKN1B PPARG YAP1 CRP VEGFA CDKN1C INS FOS CDKN1A IL6 CREB1 BCL2L11 VAMP2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 EGFR RAF1 SMAD4 TGFB1 TGFBR3 AXIN1 NRAS TGFBR1 TSPAN8 CTNNB1 HGF MFGE8 DKK4 ERBB2 KRAS MET WNT3A HRAS MTOR TGFBR2 TGFA APC CD133 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion MYL11 MYL5 MYLK MYL7 ITGB1 LAMB3 CCND2 TLN2 TXK LAMB2 MYL12A MYL12B MYL10 VASP SRMS CAV3 TNK1 PARVB VAV1 PARVG VAV2 ARHGAP5 DOCK1 SRC STYK1 KDR SHC1 c-fgr PDGFRA ZYX PDPK1 HGF ERBB2 FLNA MET FYN SHC4 SHC2 SHC3 PDGFC HEL-S-28 EGF ITGB3 ITGA2B CCND3 RAC3 LAMC1 PXN IBSP PIK3R3 ITGA1 PAK6 PAK4 PIP5K1C ITGA2 COMP BLK CCND1 ITGA4 MAPK10 COL1A1 ITGB7 LAMA5 MAPK9 MAPK8 PPP1CC THBS1 PPP1R12B HEL-S-80p VTN RAP1A PPP1R12C TLN1 PARVA CRKL SPP1 ACTN1 ACTN4 PIK3R2 PIK3R1 LAMB1 RAPGEF1 RASGRF1 PTEN RAC1 HRAS EGFR PAK1 TNC FLT1 PDGFA BRAF IGF1 VEGFA IGF1R CTNNB1 EMP2 AKT3 MAPK1 MAPK3 COL1A2 MYLK2 MAP2K1 PDGFD BCL2 RAF1 ACTG1 HEL114 PRKCB PRKCA COL2A1 ARHGAP35 MYL2 RELN VEGFB VEGFC GSK3B VEGFD XB PIK3CD TNR CRK COL4A2 BIRC2 ROCK1 COL4A1 BIRC3 ROCK2 JUN COL4A4 COL4A6 PIK3CA CAV2 CHAD ARHA BAD CDC42 FLNB COL5A3 COL5A2 ITGB5 ITGB4 TNK2 LAMC2 PS1TP5BP1 PTK6 ITGB8 ITGAV ITGB6 VAV3 VWF ITGA7 ITGA6 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 MYLK3 SOS1 THBS3 MYLK4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation AP3D1 TM6SF1 HTT SPCS3 HOMER2 AGAP2 RAMAC ZNF592 PDE8A RNMT WDR73 BNC1 BTBD1 GOLGA6L4 ADAMTSL3 SH3GL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB DNM3 RYR1 NMBR RYR2 EGF AP3B2 SPCS2 RAF1 SPCS1 ALPK3 ZSCAN2 SYNJ1 SHANK3 SHANK1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 CYP11A1 HSD11B2 SRD5A2 POR CYP21A2 STAR H6PD HSD3B1 HSD17B3 CYP17A1 CYP11B2 HSD3B2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair TDG POLE4 SMUG1 HMGB1 PARP2 PCNA PARP1 FEN1 MPG PNKP OGG1 UNG POLD3 POLD4 NTHL1 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 POLD2 NEIL2 APEX1 POLE3 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling ACTA2 COL1A1 CXCR4 MAPK8 TGFB1 STAT1 STAT3 SOCS5 CCL11 TNFRSF1A NFKB1 IL4 SOCS1 IL19 CCNB1 MAPK1 TNF RAC1 MAPK3 JAK1 IL20RA MAPK14 IL20RB MUC5AC G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling RHPN2 HEL-S-15 MYBPH PIK3CD CIT MAPK10 ARHGDIG WASL PIP4K2A MYL1 ROCK1 WAS ROCK2 SH3RF1 PIK3CA ARHGDIB HEL-S-80p LIMK1 ARHA PIK3R2 CDC42 CALM1 IQGAP1 TNK2 CYFIP1 RPS6KB1 PKN1 GNA13 ARHGEF1 RAC1 CFL2 PFN1 RTKN 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation LEP POMC GHSR GHRL MC4R SIM1 INSR LEPR BDNF INS NTRK2 AgRP NPY CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE HSD3B2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT2 GALNT16 GALNT1 B3GALT2 B3GALT1 B4GALNT1 B4GALT1 CERS3 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 KDSR T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFD IDO1 TGFB1 CXCL12 PDGFA ARG1 VTCN1 VSIR TIGIT VEGFA B2M IL10 SHH TNFRSF4 HAVCR2 IL13 ENTPD1 TNFRSF9 FAS HLA-A PDCD1LG2 IL4 IL6 FAP NR1i1 PDGFD CTLA4 CCL17 PDCD1 PDGFC ICOS CCL22 TNLG5A CXCR4 LGALS9 CD40 TNFSF6 CD80 CD40LG TNLG2B CD226 NT5E VEGFB VEGFC NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining PRKDC POLL WRN POLM NHEJ1 XRCC5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome MMP9 CAMK2A CDKN2A BDNF SRC SHC1 AGAP2 HCN1 FYN RPTOR PTPN11 DEPTOR MLST8 EIF4E GRIA2 GAD1 EPHA4 RPS6KB1 RHEB AKT1S1 DAG1 TSC2 APP TSC1 ARAF ARC CLTB DLG4 CYFIP2 GRIP1 CPT1A SH3GL1 GRIP2 ARHGAP32 ABCD3 KCNC1 DLGAP3 TTI1 ALDH5A1 TBC1D7 PICK1 EPS8L1 NF1 CYFIP1 FMR1 GRIN2B SYNGAP1 PTEN PPP3CA SHANK1 SLC6A1 ALDH3A2 HOMER1 MAP1B PLCB1 BRAF CAMK1 AKAP5 GRIN1 MAPK1 KRAS KCND2 MAP2K1 MAP2K2 RAF1 EIF4G1 ABAT EIF4EBP2 DUSP3 PRKCA DICER1 EEF1A1 PRKAR1A TARBP2 AGO2 DKFZp762B153 GPHN RAP1GAP PLCG1 NTRK2 GABRG2 SH3GL3 MTOR EIF4A1 CLTC CLTA AP2A1 GABRB2 AP2S1 CLTCL1 PPP2R5B AP2M1 CREB1 CNR1 GRB2 SOS1 PTPN5 CAMK4 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism EBP CD36 CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR FDFT1 DGAT1 SQLE ABCG8 ABCG5 APOA4 MTTP APOB LDLR ACAT2 HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK MVD SLC27A4 SAR1B MGAT1 NPC1L1 FABP2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 PTGS1 NR1C1 MVD PTGS2 WNT1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CREBBP HDAC10 SRC STIM1 NRG1 GRM6 GRIA2 GRIN3B GRIN3A GAD1 GRIA3 GRIA4 SDCBP STAT3 CRTC1 HEL-S-162eP ARC PDIA2 DLG4 GRIP1 SLC6A13 DLGAP3 SLC6A11 PICK1 FRMPD3 ADARB1 CACNG8 SLC6A12 CACNG2 EFNB2 NETO2 CPEB3 CABIN1 ARHGEF9 GABRR3 SLC1A1 GRM3 GABRR1 NPTN NRXN3 GRIN2B ADIJ ADII NWD1 SLC6A8 SNX27 GLS2 ATAD1 SYVN1 LHFPL4 SLC6A1 SNX14 HOMER1 PLCB1 STAT1 CDH2 GRIN1 GRIK5 SLC1A2 GRIK3 GRIK1 MAPK1 GRM2 ERBB4 GRM4 MAPK3 GRM8 MAP2K1 FFAR1 ORAI1 MBD5 SUMO1 HDAC1 ABAT GNA11 SLC7A11 PRKCA PPP2CA DKFZp762B153 PIG59 GRIK2 GABRG2 SH3GL2 SLC1A3 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG1 SLC32A1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 CS ALDH3A2 ACSS2 ACO2 ALDH9A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT PRF1 FOXO1 GATA2 MYC CCL5 TNF CCL2 CCL4 CCL1 ADAM17 ADAM10 FCGR3A IFNG CD226 CSF2 MICA BMI1 KLRK1 NCR3LG1 MICB CD96 NCR1 CCL3 NCR3 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAP3K21 MAPK9 MAPK8 ARAF BRAF MAP3K1 PARP14 MAP2K3 MAPK1 MAP2K4 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 PARP1 RAF1 MAP3K8 MAP3K7 MAP3K12 TNKS ATF4 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA LAG3 TGFB1 CXCL12 CCR2 VEGFA NRP1 HLA-DRB1 KDR FAS CSF1R IFITM2 CSF1 CCL5 CCR5 BAG3 HLA-DRA CCL2 CTLA4 CXCR4 TNFSF6 CD80 ITGB6 CSF2 CXCR3 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN1 PLAGL1 PCM1 ACTR1B KIAA0753 CEP170 BMERB1 DCTN6 OFD1 NDE1 ABCC6 DCTN4 MARF1 CEP20 DCP1A GATA3 ACTR10 DCP2 RAPGEF4 RAP1A DISC1 PLK1 ABCC1 PAFAH1B1 PLAG1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 PIK3R5 CACNA1A PRKCZ MAPK8 INSR PDX1 SLC2A2 SURF1 PHKA2 IRS1 IKBKB SOCS4 MAPK1 TNF INS-IGF2 MAFA MTOR FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 FOXP3 IL6R IL2 IL7R IL6 IL2RG STAT3 STAT5B CD80 IL2RA IL6ST IL2RB CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 IKBKB CHUK RELA REL NFKBIA IKBKG NFKBIE ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 LMF1 LDLR PLTP GPIHBP1 LPL ANGPTL4 APOA5 ANGPTL8 APOC2 ANGPTL3 LIPC APOA2 SEL1L RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 RALBP1 EXOC2 EXOC8 YBX3 KRAS RAC1 NRAS RAC3 HRAS RALA WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath GSK3B MAPK9 MAPK8 TSC2 CSNK1D TSC1 CSNK1G1 AXIN1 ROR2 FRAT1 CSNK1A1 CSNK1E CTNNB1 LRP5 NLK MAPK1 LRP6 SOX1 ARHA RYK NFATC2 ROR1 PI4K2A MTOR APC CDK6 CTBP1 BCL9 ARRB2 PPARG LEF1 PRKCB GSK3A MAP3K7 TCF4 DVL1 STM7 DVL2 TCF7L2 PRKCA TCF3 DVL3 RAC1 CCND1 GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RAD1 RAD9B CHEK1 RAD9A ATRIP RPA3 RPA1 HUS1 ATR TOPBP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis GPC6 COL1A1 COL3A1 SPARC YAP1 SNAI2 EDNRA TEAD4 TWIST1 PBX3 THBS2 TEAD2 TEAD3 NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway ABCC5 HGF NRG1 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 TGFB1 TXN SERPINA1 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 SLC2A3 GSTM3 SLC2A2 ABCC3 SLC5A1 HEL-S-128m SLC6A5 SLC5A2 SLC6A7 SLC6A20 SLC6A8 SLC6A9 DNAJB1 SLC5A5 GSTM5 SLC6A1 EGR1 SLC6A2 TGFBR2 SLC2A14 SLC6A19 SLC2A11 UGT2B7 ABCC2 SLC2A10 SLC6A18 SLC2A13 SLC2A12 GSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A8 HBEGF RXRA HEL-75 GCLC GSTM2 NFE2L2 GSTA5 GSTA4 CYP2A6 GSTA3 SLC6A3 SLC39A9 UGT1A1 EPHA2 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC7A11 ALDH3A1 FTH1 SLC39A8 SLC2A9 GSTM4 SRXN1 SLC2A6 SLC2A7 SLC2A8 KEAP1 MAFG ME1 SLC39A14 GPX2 HEL-S-25 FTL HEL-S-22 SLC5A12 SLC5A10 HMOX1 UGT1A4 UGT1A7 TXNRD3 MAFF ADH7 GCLM FGF13 HSP90AB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 APP PSEN2 SIRT1 PSEN1 GDF8 PSENEN BACE1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 ID2 ID3 CCNE1 ID1 PAX8 RBL2 RBL1 RB1 CDK2 PAX2 MYOD1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGV PIGY PIGM PIGC DPM2 PIGB PIGW PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index TLX2 HDAC5 STAT3 LEFTY1 TLX1 TLX3 LEFTY2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 LTC4S PTGS2 ALOX5 ALOX15B ALOX15 ALOX5AP PLA2G5 PLA2G6 PTGS1 PTGIS PLA2G4B PRXL2B PTGES OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response MAPK10 CASP9 CASP3 BAK1 APAF1 TRAF3 TRAF2 TRAF6 C5AR1 MAP3K1 CDKN1C NFKB1 MAP2K4 TNF MAPK13 BAD GADD45A PCNA C1R CDC42 BCL2 CDKN1B C1QB C1QA TNK2 C4B_2 C2 CDKN1A C3AR1 TNFRSF1B BAG4 CR2 TRAF1 NFKBIE CYCS C1QC HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PLCB4 PRKD3 PLCB1 EGFR SMAD2 PLCB2 FLT1 INSR CDH6 FGFR4 CDH2 CDH16 IGF1R KDR PDGFRA CTNNB1 PRKAA2 MET PRKAG1 FLT3 PRKAG2 PRKAG3 FGFR2 PRKAA1 LEF1 PRKACG EPHA2 PRKAB2 PRKCH PRKCB PRKAB1 GNA11 PRKCE PRKCA NTRK1 TCF7L2 TCF7L1 CDH9 KIT CDH8 PRKAR1B GNAL PRKAR1A CDH4 PRKCI CDH10 PRKCQ CDH11 CDH12 CDH15 CDH17 CDH19 NF2 PRKCZ CDH24 NGFR WWTR1 YAP1 GNAI3 CSF1R NTRK2 ARHA GNAS MTOR CDC42 FGFR1 FLT4 CDH18 LATS1 PLCB3 TEAD4 LATS2 RAC1 TEAD2 TEAD3 FGFR3 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CCND2 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 TFAP2A WNT5B WIF1 SOST LEF1 CCND3 NKD1 NKD2 MAP3K7 DVL1 DVL2 TCF7L2 TCF3 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 MACROH2A2 ATF3 CXXC4 PORCN GSK3B CDK8 WNT2B HNRNPK NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 FRAT1 FRAT2 AXIN2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CDK6 CTBP1 FOSL1 FZD1 RUVBL1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 APC2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders TF PANK2 CYBRD1 HFE2 HAMP HEPH FTL STEAP3 FTH1 UQCRFS1 CP TFRC HFE TFR2 SLC40A1 SLC11A2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 PPP5C TSC2 PPM1D RBBP8 RNF20 MRE11A MDC1 ATMIN RIF1 CEP63 IKBKG KAT5 TRIM28 RAD50 TP53BP1 NFKB1 LMNB2 CDK2 NHEJ1 MAPK12 MAPK13 ATF2 MAPK11 MAPK14 MTOR PRKDC HMGN1 ATM RNF168 NBN ATR SMC1A RNF8 AURKB HEL-S-102 PPP2CA STK11 CDK5 CHEK2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2B P2RY6 P2RY4 P2RY2 P2RY1 LPAR4 ADORA2A LTB4R SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer SERPINB2 IRF7 CDKN2A SMAD4 INHBA BRAF IGF1 CEBPB IGF1R IL24 SRC INS MAP2K3 MAPK1 MAP2K1 MAPK14 LAMP2 IL6ST MLST8 BCL2 RAF1 ATG3 CDKN1B GABARAPL2 PLAT ATG12 SLC39A2 IGFBP5 SLC39A1 ATG16L1 SLC39A3 AKT1S1 IRF1 IL6R MAP1LC3A MAP1LC3C SQSTM1 IFNG RB1 SH3GLB1 UVRAG ATG10 BMP2 GSK3B HMGA1 CD44 COL1A1 DKFZp762B153 COL3A1 RB1CC1 SPARC TGFB1 CDC25B JUN ING1 COL10A1 GABARAPL1 THBS1 TNLG1B ATG14 ATG5 RNASEL VTN IL6 GABARAP CXCL8 AMBRA1 IFI16 CREG1 RSL1D1 ULK1 MTOR IL3 PCNA MDM2 KMT2A CDKN1A PTEN IFNB1 IL1B BMI1 HRAS CXCL1 CXCL14 IGFBP7 IL1A MMP14 CCL3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling PAK1 RELA HEL-S-81p GAB2 VAV1 SH2B3 ZAP70 GRAP2 SHC1 PDPK1 LCP2 CARD11 BCL10 MAPK1 FYN MAPK3 NFATC2 LAT ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 RAF1 MAP3K8 MAP3K7 REL PTK2B PRKCQ LCK MAP4K1 MAPK9 MAPK8 CD3G CD3E CHUK CD3D CD8A TRAF6 CRK IKBKG WAS PLCG1 JUN NFATC1 NFKB1 MAP3K14 ITK CRKL PSTPIP1 RIPK2 FYB1 PIK3R2 PIK3R1 CDC42 ICOS CBL NCK1 VAV3 FOS IKBKB CREB1 HRAS GRB2 SOS1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GCK GLS UGDH LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 CD36 BMP1 FGFR1 GLUD1 FGFR4 PSAT1 PLCG1 P4HA2 PSPH ALDH18A1 HEL-S-133P ARHA PHGDH P3H4 P3H3 PLOD1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR AGXT GLYCTK AQP9 KHK GPD1 LIPE ALDOB PC FBP1 GPD2 PFKL HEL-S-162eP ENO1 HEL-S-68p MGLL HEL-S-165mP PGAM1 HEL-S-49 G6PC1 HEL-S-87p PNPLA2 AQP7 PCK1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling OXTR PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP9 CASP3 APAF1 PINK1 UBE2L6 PARK2 UBE2L3 CASP2 DDC MAPK12 MAPK13 MAPK11 MAPK14 GPR37 UBB SEPT5 LRRK2 SLC6A3 ATXN2 HEL-S-67p CASP6 CCNE1 UBA7 TH EPRS1 SYT11 HEL-117 UBE2J2 CCNE2 UBE2J1 SNCA HTRA2 UBE2G1 UBE2G2 SNCAIP CYCS IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFD MMP9 TGFB1 CXCL12 VEGFA IL10 IL13 IL2 IL4 IL6 IL5 CXCL8 CCL5 TNF CCL28 CCL2 CXCL5 CCL20 LGALS9 IL25 REG4 IL12B IL12A IFNG IL23A IL1B IL17F CSF2 IL17D IL17C IL17B CXCL1 VEGFB IL17A VEGFC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 YES1 WWTR1 H4C9 SRRT FGF7A HIST1H4L SOX12 POU3F1 UTF1 SOX15 ZSCAN10 SOX4 SOX2 TEAD2 POU3F2 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair PCNA POLE4 RFC2 MSH6 RFC3 RFC4 RFC1 POLD3 MSH2 POLD4 POLE LIG1 PMS2 POLE2 POLD2 POLE3 RPA3 RPA1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP8 ATP6 COX17 ATP5MC2 ATP5J ATP5MC3 COX7A2 ATP5H COX11 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 SLC25A14 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HEL-S-123m SLC25A27 UCP3 UCP2 NDUFA7 NDUFA6 NDUFA5 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX4I1 COX6A1 COX8A COX6B1 COX7A1 SDHC SDHD UQCRB SDHB COX3 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 UQCRC2 SURF1 COX1 SDHA SLC25A5 SLC25A4 SLC25A6 UCP1 NDUFA13 COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 NDUFA9 NDUFA12 NDUFA10 COX6A2 HEL-S-271 ATP5IF1 COX7A2L SCO1 ND1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ACTA2 ITGB1 MAPK10 ITGB7 NF2 MAPK9 MAP4K1 MAPK8 PAK1 MAP4K2 WWTR1 YAP1 MAP4K3 SRC CTNNB1 CTNNA1 ACTG1 ITGB5 ITGB4 ITGB3 YWHAQ PS1TP5BP1 ITGB8 SGMS1 ITGB6 ACTA1 LATS1 LIMD1 TEAD4 PAK6 PAK4 TEAD2 TEAD3 HEL-S-31 ACTG2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 EGF ZEB2 LTBP1 ZNF423 BAMBI LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway SHC1 ERBB2 SOS2 SHC4 SHC2 SHC3 EGF RPS6KB2 E2F2 RPS6KB1 NBN DDB2 PIK3R3 RB1 CETN3 GADD45B GADD45G CCND1 ARAF BAX FZD10 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B GADD45A PIK3R2 PIK3R1 TNFSF11 FZD1 WNT10B WNT10A FZD3 ATM FZD2 FZD5 FZD7 FZD9 ATR FZD8 PTEN BRCA1 BRCA2 HRAS APC2 NCOA1 FGF23 EGFR BAK1 MRE11A BRAF NRAS IGF1 CSNK1A1 WNT7B IGF1R WNT7A RAD50 RAD51 FGF10 CTNNB1 CDK4 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 NR3A2 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 PGR RAF1 LEF1 HES1 DVL1 HES5 DVL2 FGF8A TCF7L2 DVL3 NFKB2 TCF7L1 WNT1 KIT WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD POLK AXIN1 AXIN2 SKP1 JUN WNT16 PIK3CA SP1 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC CSNK1A1L CDK6 JAG2 E2F3 PARP1 FGF18 FGFR1 FLT4 HEY2 FGF2 FGF7B FGF7A FOS DLL3 DLL4 CDKN1A FGF5C GRB2 SOS1 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes MMP9 SMAD2 ANGPT1 MAPK9 MAPK8 KITLG TGFB1 RELA CXCL12 RELB TGFBR1 DKFZp781O1323 KDR NFKB1 MAPK1 MAPK3 SMAD1 NOTCH3 NOTCH1 SMAD9 CXCR4 EPHB4 FLT4 EPHB2 DLL4 NFKB2 HIF1A KIT ACVRL1 REL CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYL11 TNNT1 ACTA2 MYL3 TNNT3 MYH8 MYH4 MYH7 MYL1 TNNC1 TNNI1 HEL-S-273 HEL-S-108 RYR1 RYR2 ACTG1 TPM3 TPM1 RYR3 PS1TP5BP1 MYH6 ACTA1 MYH13 TNNI2 MYL2 TNNI3 TNNC2 MYH1 ACTG2 MYH2 MYL6 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine AANAT SPR PAH MAOA ASMT JDP1 PTS PNMT TH DHFR DBH NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 RELA DDX3X TRAF3 CASP10 MAP3K1 ISG15 TNF IFNK MAPK12 MAPK13 MAPK11 MAPK14 NFKBIA TBKBP1 NFKBIB IKBKE ATG12 MAP3K7 IFNE RIPK1 IFNG TANK MAPK10 MAPK9 MAPK8 OTUD5 CHUK CXCL12 TRAF2 TRAF6 DDX3Y TBK1 DHX58 IKBKG TRIM25 AZI2 SIKE1 RNF125 NFKB1 CYLD PIN1 ATG5 CXCL8 MAVS SNW1 CASP8 RIGI FADD TRADD IFNB1 IKBKB MITA NLRX1 IFNA1 IFIH1 IRF3 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 LBR HMGCR NR1H2 CH25H FDFT1 IDI2 PLPP6 FADS2 SCD CYP7A1 CYP27A1 MYLIP ELOVL5 ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK HMGCS1 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP6 ATP5MC2 ATP5J ATP5MC3 ATP5H NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 HEL-S-123m NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COXFA4L2 ATP6AP2 NDUFS8 NDUFS3 COXFA4 NDUFA11 NDUFA9 NDUFA10 HEL-S-271 ND1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 NF1 KRAS NRAS BRAF HRAS PTPN11 GRB2 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling GSK3B CREBBP CASP9 PDGFA IKBKG FOXO1 PIK3CA NFKB1 CTNNB1 AKT3 KLK3 MAPK1 KRAS BAD MAP2K1 MTOR NFKBIA MAP2K2 BCL2 RAF1 CDKN1B MDM2 CDKN1A GRB2 CCND1 SOS1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IF2B1 IL23R IL17RC STAT3 IL12RB1 IL12B TYK2 CXCL8 IL23A IL1B IL17F HLA-C TNF CCL20 CXCL1 IL17A CCR6 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM1 RYR1 MYLK PLCB1 PPP1R14A MYL1 ROCK1 ROCK2 IL13 GDI1 ADRB2 HEL-S-80p ARHA OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 NFKB1 IKBKB CHUK MAPK1 RELA ITGB3 MAP3K14 SPP1 MAPK3 MAP2K1 ITGAV HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG3 RB1CC1 ATG12 WIPI1 ATG16L1 MAP1LC3A ATG5 ZFYVE1 ATG16L2 ATG10 ULK2 MTOR ULK1 PIK3R4 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 ABCC2 AKR1D1 AKR1C4 SLC27A5 SLC51A HSD3B7 ABCB4 SLC51B ABCB1 BAAT ABCC3 CYP7B1 SLCO1B1 FABP6 SLC10A2 AMACR ABCB11 SLC27A2 ATP8B1 HSD17B4 CYP7A1 ABCD3 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 HSD17B2 F13B HSD3B1 HSD17B3 HSD17B7 CYP17A1 HSD17B4 HSD17B1 HSD3B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB4 PIK3CD PLCB1 PLCB2 TSC2 TSC1 YAP1 ROCK1 PKN2 PIK3CA AKT3 MAPK1 ARHA MTOR PIK3R2 MOB1A PIK3R1 PKN3 PKN1 PIK3R3 LATS1 PLCB3 TEAD4 LATS2 TEAD2 TEAD3 TRIO SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways CALCA HEL-S-14 MYLK PLCB1 GNAI1 MYL1 CAD HEL-S-7a GNG13 EDNRA RAMP1 GNA15 MAPK1 NPY GNAS MAP2K1 COX2 CALCRL GNB5 ECE1 EDNRB CALM1 ADRB1 NPY1R RIIAD1 ATP2A2 RAF1 ADRA1A EDN1 PRKCA PTGIR LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 CS SLC19A2 NONO SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B CYP2C8 CYP8B1 COX1 PLCB1 ALOX12 LTC4S PTGS2 CYP2C9 ALOX5 CYP2B6 ALOX15 HPGD CYP7B1 CYP4F2 GPX4 FADS2 PLA1A CYP7A1 EPHX2 PRXL2B CYP27A1 PTGES VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism HEL-S-53e RXRB CD36 RXRG HEL-S-4 CYP26A1 SULT1A1 SULT2B1 ADH1A CYP26B1 RLBP1 RPE65 DGAT1 SDR16C5 RXRA MAPK1 RDH12 ABCG8 AWAT2 ABCG5 LRAT BCO1 SCARB1 RDH8 ALDH1A3 CRABP2 RETSAT RARA CRABP1 LPL DHRS3 RBP7 RBP4 RBP2 RBP1 RDH5 CYP2E1 ALDH1A2 NR1B3 RDH10 NPC1L1 RARB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 ST3GAL5 A3GALT2 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 TNLG7C DKK1 EDARADD DKK4 LTB WNT3 PTCH1 RELB EDAR SHH SOSTDC1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH GH1 GNRH1 SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 HEL-S-53e GLYCTK KHK HEL-S-49 SORD ALDOB G6PC1 FBP1 PFKL SLC2A2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI NEDD4 TGFBR2 TGFBR1 ATG16L1 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing SRPK2 PPM1G RNMT YBX1 SUPT5H HNRNPH1 NCBP1 NCBP2 SMC1A SRSF9 TMED10 PTBP1 METTL3 SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A NONO PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 HNRNPD SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA FUS SNRPB DHX8 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 WDR57 SFRS3 CLK4 SFPQ LSM2 CLK2 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 DICER1 CSTF2T U2AF1 PABPN1 POLR2A U2AF2 TRA2B SNRPB2 SF3B1 DDX1 SF3A1 SF3A2 HNRNPK SPOP HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRPK1 SRP54 DHX15 PRPF40A SRSF10 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB4 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 RETN RELA CHUK PLCG2 PLCG1 IKBKG PIK3CA NFKB1 IL6 AKT3 CXCL8 MAPK1 TNF MAPK3 MAPK14 NFKBIA PLCE1 IL12B IL12A PLCB3 IKBKB LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis MMP9 CXCL2 CCR2 PDGFA IGF1 CEBPB CCL11 HGF CCL5 TNF SFTPC CCL2 CCL4 TGFA EGF BMP7 NFE2L2 IL12B TERT TIMP1 CALCA TGFB1 CSF3 FAM13A SFTPA2 MT2A KPG_011 ATP11A CTGF RTEL1 DPP9 STN1 CMA1 IL13 MUC5B HMOX1 IL4 IL6 IL5 SERPINA1 CXCL8 SPP1 FGF7 CCR3 ELMOD2 PTX3 SFTPA1 FGF2 GREM1 EDN1 MMP2 IL1B CSF2 SKIL CCL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK HEL-S-162eP PFKL ENO1 ENO2 PFKM ENO3 HEL-S-68p MPC2 PGAM2 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-30 HEL-S-87p HK2 PCK1 SLC2A4 PDHA1 MDH2 GOT2 PKLR ALDOB PC FBP1 SLC2A3 SLC2A2 LDHB MPC1 HEL-S-133P DLAT HK3 G6PC1 HEL-S-32 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO GOT2 AGXT SLC26A1 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FBP1 VEGFA FOXO1 PIK3CA HEL-S-68p KDR MYC HIF1A PGAM1 HEL-S-133P OTUD7B G6PC1 OTUB2 USP37 U2AF2 USP44 SIRT7 MTOR HK2 VHL USP28 USP19 OTUD6B ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 KCNQ2 BRSK1 SEMA3A ANK2 L1CAM SCN5A SPTAN1 PRRT2 CSNK2A1 EIF2A CSNK2A2 SCN2A DDIT3 CSNK2B SNAP25 ATF4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap MTR CTH GCLM CBS METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 ANXA2 MTTP APOB LDLR APOE LPL ABCA1 LIPG APOC2 LIPC APOA2 PCSK9 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BIRC5 HEL113 APP AXIN1 HEL-S-89n NFKB1 THBS1 SOCS3 NRG1 YBX3 MAPK1 JUND TNF RIPK2 F2R ERBB3 GCLC ERN1 CTNNA1 IL7R CDKN1B CUL5 APOE BEX3 RNF7 NQO1 HELLS HDAC1 NET1 CARD14 TNFRSF21 RPS6KB1 PKN1 VAV3 HEL-S-7 CDKN1A SQSTM1 HEL-S-102 PTK2B TNFRSF10B TRAF1 HSPD1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DCTN1 YWHAQ DCTN6 TH PAFAH1B1 DCTN5 DCTN3 HEL-S-1 YWHAG NDEL1 DCTN4 HEL-S-77 YWHAZ DDC PPP2CA HEL2 CDK5 DBH DISC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MYLK PIP4K2A VAV1 DOCK1 PDGFRA RRAS2 SOS2 WASF1 EGF FGFR2 RAC3 PXN PIK3R3 STM7 ITGA1 PAK6 PIP5K1A PIP4K2B PAK4 PIP5K1C MYL3 WAS ARHGEF4 RRAS CYFIP2 BDKRB1 PIK3R4 ACTN1 PIK3R2 PIK3R1 GNA13 RAC1 APC2 CD14 FGF23 EGFR PAK1 MYL1 FGFR4 ARHGEF7 PDGFA BRAF NRAS CHRM1 FGF10 BDKRB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAF1 ACTG1 HEL114 F2 FGF8A ARHGAP35 CFL2 FGF6B PFN1 EZR HEL-S-15 PIK3CD CHRM2 CHRM3 CRK ROCK1 ROCK2 GNG12 PIK3CA TMSB4X LIMK1 ARHA FGF20 FGF22 FGF7 FGF21 FGF8 F2R FGF9 FGF16 APC FGF14 CDC42 PIK3R5 FGF13 FGF18 FGF12 IQGAP1 FGFR1 PIK3C2G PIK3C2A PIK3C2B PS1TP5BP1 FGF2 FGF7B NCKAP1 CHRM4 FGF7A CHRM5 HEL70 MYH10 RDX RASSF7 ARHGEF1 ARPC5 MAPK6 SSH2 SSH3 MAPK4 BRK1 FGF5C PIP5KL1 FGD1 CSK WASF2 BAIAP2 MOS SOS1 ABI2 FGFR3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 NFE2L2 MAPK8 HEL-S-22 NQO1 CES1 ABCC6 JUN ABCC3 FOS HMOX1 ABCG2 EPHX1 MAPK12 MAPK13 SRXN1 MAPK11 GCLM MAPK14 NQO2 KEAP1 GCLC IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling MMP9 ACTA2 RORC DCSTAMP SMAD2 MAPK9 MAPK8 CASP3 RELA STAT1 STAT3 BAX IL10 JUN NFATC1 PIK3CA TYK2 ATP6V0D2 SOCS3 IL6 CXCL8 MAPK1 TNF DDIT3 MAPK3 MAPK14 NFKBIA COX2 CCL20 IL33 TNFSF11 EPHA3 DEFB4B MPO CTSK IL10RB IL1B CSF2 JAK1 IL20RA IL17A IF2G MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IRAK1 TIFA TLR4 UBE2V1 MYD88 TRAF6 TLR1 JUN NFKB1 TLR10 TLR5 HEL-S-71 TLR9 TLR8 TLR7 IL1A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells KIR2DL1 KIR2DL3 ELF3 NLRP7 NLRP2 VAV1 PLCG1 PRKCA LCP2 IFNG CSF2 HLA-C TNF RAC1 FYN LAT TYROBP PRKCQ SYK PTPN6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR1D2 RORC RORA RXRB NR2F6 RXRG NR2E1 NR2F1 NR0B1 NR5A2 NR1H2 NR1C1 NR1A2 RXRA NR1I3 NR1i1 NR5A1 ROR1 NR2F2 NR3A2 NR1i2 PGR RARA NR2C2 NR2A1 PPARG NR3C1 ESRRB NR1C2 NR1B3 NR1H3 THRA ESRRA RARB FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 LMF1 LDLR PLTP GPIHBP1 APOA5 APOC2 LPL LIPC APOA2 SEL1L SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network SELENOK PTGS2 RELA INSR CRP HEL-S-97n FLAD1 PRDX3 PRDX5 INS HEL-S-2a TNF GPX1 CCL2 HEL-S-44 HEL-75 SCARB1 APOB SERPINA3 LDLR SAA4 HBB MTR PLAT PLG HEL-S-302 SELENOF MPO SELENOI SELENOH ABCA1 SEPHS2 FGA HBA2 GPX6 F2 PTGS1 SELENOO HEL-S-78p NFKB2 F7 SELENON IFNG SELENOM ALB SELENOP SAA1 SELENOW SAA2 GPX4 SELENOV SELENOT MSRB1 SELS GPX2 ALOX5 ALOX15B ALOX5AP DIO1 CBS TXN NFKB1 TXNRD3 IL6 CTH XDH GPX3 TXNRD2 IL1B KMO KYNU DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis OXCT1 HMGCS1 ACAT1 ACAT2 BDH1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 HFE2 HAMP BMP6 ID1 HFE TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma ELOC BIRC7 CREBBP TGFB1 EP300 TFEB VEGFA CTSK SETD2 FH CADM2 DVL2 ARNT2 CDKN1A PRCC RBX1 COL21A1 EGLN1 HIF1A EGLN3 EGLN2 VHL TGFA SFPQ BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 GSTM1 MPO CYP2E1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders XDH ADA DGUOK HPRT1 TPMT RRM2B ADSL HEL-S-70p PNP MOCOS AMPD1 PFAS PAICS APRT AOX1 IMPDH1 ADSS 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV SDF2L1 CAMK2A NEDD4 PPIB RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RNF19B RPS12 VPREB1 RPS9 CWC22 AQR RPS7 RPS8 CRNKL1 RPS5 PDIA4 RAB36 DNAJB11 RPSA PPIE RPS6 SNRNP200 GNAZ CD79B UBA6 CABP1 CD79A AK8 CWC15 TDRD3 GGTLC2 ZNF280A RPS15A HEL-S-107 RPS19 ARIH1 RPS3 CCDC116 BUD31 RPS2 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A RILP UGGT1 RPS26 PPIL1 CDC5L RPS28 IGLL5 XAB2 CHEK1 RPS29 YPEL1 PPIL4 RPS20 PPIL6 RPS21 RPS24 RPS23 IGLL1 PARK2 UBE3A UBE2L3 HEL-S-89n IQUB HEL-S-99n ROPN1L RSPH6A PDIA2 DNAJB13 NME5 DYDC1 RSPH9 RSPH3 MDM2 XBP1 RSPH14 SNRPD2 SNRPD1 SNRPD3 PAK1 SNRPG SNRPE SNRPF CAMK1 SNRPB FAU PRPF8 MAPK1 WDR57 HEL-S-125m DHX16 RPS11 RPS27A SNRPA1 SF3B5 SF3B2 SNRPB2 SF3B1 SF3A1 ELOC SF3A2 PHF5A HYOU1 RBX1 SNW1 CANX BCR SOX9 CBL PTPA CAMK4 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy STX1A CAMK2A DAG1 RAB1A SCN8A ZNF547 TRAPPC3 PRRT2 GIGYF1 TRAPPC6B KCNQ5 NEDD4 AKAP5 SCN2A SCN4B RAB11A SNAP25 KCNQ2 CALM1 KCNQ3 FGF13 FGF12 PRKCE BACE1 VAMP2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 HSD17B2 HSD3B1 HSD17B3 SULT1A1 UGT1A1 CYP17A1 HSD3B2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation NCKAP1L VAV1 GATA2 KLF1 CSF1 CD34 NFATC2 MYB NOTCH1 MUC1 CXCR4 RUNX1 SPI1 ITGB3 LEF1 ITGA2B XB KITLG CSF3 EPO TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 GATA1 ABO MXI1 NFE2 IL6 IL5 RIOK3 NR1A2 MHC2TA FLI1 ARHH GP9 TPO HES6 IL3 PIM1 LYL1 FOS IL1B CSF2 ACVR1B FOSB IL1A EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 IL1B PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CSRP2 CTNNB1 CDK4 SOX4 RB1 PMAIP1 MACROH2A1 CCND1 MED1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease HBA2 TLR4 IL18 HBB IL1B BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 LDLR FGF8A ABCB11 MAPK1 FGFR4 ABCG8 MAPK3 ABCG5 FXR1 CYP7A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling RAF1 EPOR STAT1 STAT3 CISH EPO SRC SHC1 SOCS1 IRS1 PTPRC MAPK1 STAT5B MAPK3 PTPRU MAP2K1 GRB2 MAP2K2 SOS1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PIK3CD PTGER3 EGFR PTGS2 BRAF NRAS SRC PIK3CA AKT3 MAPK1 KRAS PTGER4 MAPK3 HRAS PLA1A PTGER2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR STAT3 MAPK1 MAPK3 JAK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL6 STAT2 HEL-S-10 STAT1 STAT3 JAK1 IL10 IL10RB IL10RA IL1A CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR NRAS IGF1R INS PIK3CA CDK4 AKT3 IRS1 ERBB2 CDK2 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 PIK3R5 CDK6 RAF1 CDKN1B PIK3C2G PIK3C2A PIK3C2B CCNE1 PIK3R3 CDKN1A HRAS CCND1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis HEL-S-53e TGFB1 ASCL1 STAT3 CDKN1C NKX2-2 SHH DDC GBX2 MSX1 SOX2 FGF8 NKX6-1 PITX3 EN2 EN1 LMX1A LMX1B OTX2 FOXA2 SLC6A3 TH NEUROD1 NEUROG2 SLC18A2 WNT1 RET GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling CDKN2A CCND2 EGFR EP300 NRAS BRAF FOXO1 IGF1R SRC PDGFRA PDPK1 CDK4 AKT3 IRS1 MAP2K3 ERBB2 CDK2 MAP2K4 MAPK1 KRAS MET MAPK3 MAP2K6 MAP2K1 MAP2K2 ERBB3 RAF1 CDKN1B FGFR2 PRKCH PRKCB PRKCA RB1 CDKN2B PRKCI PRKCQ CDKN2C CCND1 SPRY2 PIK3CD MAP2K5 PRKCZ TSC2 TSC1 ARAF PLCG2 PLCG1 MSH6 PIK3CA ERRFI1 PIK3R2 PIK3R1 CDK6 MDM4 FGFR1 PIK3C2G FOXO3A FOXO4 PIK3C2A NF1 MDM2 PIK3C2B CCNE1 ATM CBL CDKN1A PTEN BRCA1 BRCA2 HRAS GRB2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A1 SLC6A19 SLC6A20 SLC36A2 CLTRN SLC3A2 SLC7A7 SLC1A1 SLC7A9 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome PCM1 MRE11A OFD1 SHH RAD50 PDE6D PDE6A FLNA PDE6G INVS NPHP3 ZNF423 RHEB DVL1 SUFU RAB8A DVL3 CEP164 BBS9 BBS7 BBS5 CEP290 ATF4 BBS4 MYO6 KAT5 RP2 TMEM216 CEP104 ARL3 ARHA ARL13B TMEM67 INPP5E MTOR BBS2 NEK8 BBS1 CETN2 CCP110 AHI-1 PARP1 ARR3 TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP41 CEP97 CC2D2A ARMC9 ATM RPGRIP1L TMEM138 ARL2 NPHP1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 B9D1 B9D2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ASL OTC NAGS GLS2 ASS1 ARG1 SLC25A13 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GALT1 B4GALNT1 B4GALT4 B3GNT5 ST3GAL5 A3GALT2 GBA2 UGT8 UGCG NEU3 NEU4 A4GALT GLA B4GALT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 GSK3B PDE4A TFAM PDE4B GUCY1B1 PARK2 HEL-S-162eP PDE4D NRF1 AKT3 PRKG1 PPARGC1A NOS2 PDE5A ZNF746 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TLR4 MMP9 CXCL2 MBP CCR2 BDNF OMG GFAP PLA2G2A FKBP1A CCL2 CDKN1B C1QB SLIT2 EPHA4 PLA2G5 PLA2G6 TNLG7A IFNG RB1 NTN1 APEX1 CDC2 MIF CCND1 CCNG1 RGMA TGFB1 FCGR2A IL2 PLXNA2 IL4 CXCL8 GADD45A SELP EFNB2 NOX4 AIF1 AQP1 LTB PPP3CA RAC1 EGR1 ANXA1 MMP12 ZFP36 IL1A SEMA6A PDYN BCAN KLK8 EGFR BTG2 HEL113 NCAN AQP4 PRB1 PTGS2 PRB2 TACR1 VCAN TNFSF13 GAP43 CD47 ACAN SLIT1 SLIT3 LILRB3 GRIN1 CDK4 MYC CDK2 MAPK1 TNF MAPK3 CSPG4 GJA1 RTN4 PRKCA IL1R1 COL2A1 GDNF E2F5 RTN4R LEP NGFR CASP3 ARG1 COL4A1 ROCK2 LTB4R IL6 ARHA NOS2 SOX9 CDC42 FOXO3A ROS1 RHOB XYLT1 FOS IL1B CHST11 CXCL1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A PPP2R2C PPP2R2B PYGB PHKG2 PYGM AGL PHKB PHKA1 PHKA2 HK2 CALM1 PPP2R1B PPP2R1A GYS2 GYS1 PPP2R2A PPP2R5E GYG1 GSK3A PPP2R5B PPP2R3B PPP2R5A PPP2R5D PPP2R5C PTPA HK3 PYGL PPP2CA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 COA3 AS3MT UQCRFS1 HEL-S-44 SDHA HEL-S-21 ND1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 PTGS2 EPHX2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A ITGB1 PAK1 CTNND2 ARHGEF7 GRIN1 RAP1A DLG4 HCN1 SPAAR ARHGAP44 SHARPIN LZTS3 ADGRL1 CDC42 SPTAN1 GRIA2 PS1TP5BP1 SHANK3 MAP3K7 GRIN2B SYNGAP1 DLGAP1 HRAS BAIAP2 HOMER1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TOMM70 IRF7 AGTR2 REN TRAF3 TRAF6 TBK1 TMPRSS2 NFKB1 CTSL MAVS RIGI ACE2 PHB2 NDUFB9 ACAD9 AGTR1 TLR7 NDUFAF1 IKBKE ECSIT TICAM1 NFKB2 CGAS NLRX1 MITA IFIH1 IRF3 TLR3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection TLR4 IRF7 CCND2 STAT2 TYK2 NFKBIA NFKBIB IKBKE CDKN1B OAS1 OAS2 CLEC4M BBC3 OAS3 IRF9 CCND3 IFNA6 IL12B MAP3K7 IL12A CCNE2 PIK3R3 STAT5B JAK3 CCND1 IL2RA IL2RB CD46 MAPK10 MAPK9 IL2RG MAPK8 CD3G CD3E STAT3 CD3D EIF3S3 BAX FCGR2B CSNK2A1 CSNK2A3 CSNK2A2 IL2 ADAR CASP8 CSNK2B PIK3R2 PIK3R1 HEL-S-103 FADD HEL-S-72p CCNE1 EIF2AK2 TRADD IKBKB JAK1 HSPA2 IFIH1 IRF3 IL1A IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 BAK1 RELA STAT1 IFNA21 TRAF3 IF1AA9 FAS CDK4 TNFAIP3 IFNA8 CDK2 MX1 LNIR CD209 BCL2L1 BCL2 RCHY1 RAB9A RAB9B TNFSF6 IFNA7 NFKB2 EIF2S1 CYCS IRAK1 PIK3CD IRAK4 CASP9 MYD88 TP73 CASP3 CHUK APAF1 TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD TLR9 TLR7 CDK6 HEL70 FOS IFNB1 IL1B EIF2AK1 EIF2AK4 IFNA1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB SLC16A7 SLC1A2 SLC4A4 SLC16A3 HEL-S-133P NUDT14 CA4 HEL-76 SLC2A3 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAP2K5 YAP1 AMOT PIK3CA NFKB1 MAP2K3 MAP2K4 MAPK1 ARHA RAC1 MAP2K6 MAPK3 MAP2K1 MTOR MAP2K2 TRIO MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYLK HEL114 LPP ITGB3 MFAP5 PLCG1 JUN ITGAV PXN TJP1 CREB1 MAPK1 MAPK3 MYL2 PRKCQ ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway KHK SORD ALDOB AKR1B1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway SLC12A2 CFTR ADCY6 FLT1 NRAS BRAF IGF1 WNT7B IGF1R PDE1A WNT7A SRC KDR CTNNB1 MYC ERBB2 PRKAA2 TNF KRAS MAPK3 MAP2K2 WNT5B PRKAG1 PRKAG2 EGF PRKAG3 PRKAA1 PRKACG PRKAB2 RHEB PRKAB1 GNA11 DVL1 DVL2 DVL3 WNT1 KCNN4 WNT3 WNT4 WNT3A STK11 CCND1 VEGFB GSK3B WNT2B TSC2 GNAI1 TSC1 FZD10 PLCG2 WNT16 GNAI3 JUN PKD1 SFRP4 GNAS MTOR SSTR2 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT9B FZD5 RPS6KA1 FZD7 WNT9A FZD9 WNT8A FZD8 FOS WNT8B IKBKB HRAS EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 LTC4S ALOX5 ALOX15B ALOX15 KPG_011 HEL-S-298 EHHADH HPGD FPR2 CYP4A22 LTB4R NR1C2 NR1C1 TRPA1 CYP4F2 CYP4A11 TRPV1 PTGR1 CYP4F12 ACOX1 ACOX3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH3 NOTCH1 MAML3 JAG2 PSEN2 ADAM10 CHUK DLK2 LEF1 MFAP1 PSEN1 MFAP2 HES1 DNER DLL3 DLL4 RRAS MAML2 MAML1 RBPJ NOTCH2 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 EBI3 GPR183 CRP TNFSF13 FOXO1 ISG15 IFITM1 MFGE8 CCL19 PTPRC TNF PAX5 ZEB2 CCL21 CXCR4 CD40 CD80 CD82 CD79A BACH2 IFIT2 C4A BLNK IRF4 CD19 CCR7 FCRL5 IRF8 TNLG7A IL12A CXCR5 CD1D SLAMF7 HEL-S-62p SH2D1A CD40LG IFNG CR2 CR1 MS4A1 CD22 IL-21 CXCL12 BCL6 TBX21 IFNAR2 IL10 IL2 IL4 IL6 BCR SYK TLR7 PDCD1 ICOS ICOSLG PRDM1 SELL CD69 HEL-S-72p XBP1 TMSB10 ITGAX MAF CXCL13 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 SELP ITGB1 KNG1 SELPLG HEL-S-62p IL6 CXCL8 C6 C7 TNF VCAM1 IL1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders UMPS RRM2B DPYS DHODH NT5C3A HEL74 TYMP HEL-S-29 RRM1 RRM2 TYMS DPYD GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GABBR2 CASR GRM2 GPRC5A GRM4 GPRC5D GRM8 GPRC5C GRM3 GRM6 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C1R MASP2 MASP1 CFD C1QB C1QA C4B_2 C2 C4A C8A CFP HEL-S-62p C6 C7 C8G C9 CD55 C1QC ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B MEF2C MEF2B MEF2D EP300 CAMK2G FOXO1 NR1C1 RXRA PRKAA2 ATF2 MAPK14 PRKAG1 PRKAG2 PPP3R1 PPP3R2 PRKAG3 PPARGC1B TFAM PRKAA1 PPARG FOXO3A UCP3 HDAC1 UCP2 SIRT1 SIRT3 PRKAB2 GABPA PRMT1 PRKAB1 NRF1 NR1C2 CREB1 PPP3CA PPARGC1A PPP3CC TFB1M TFB2M NCOA1 PPRC1 ESRRA MED1 MYBBP1A CAMK4 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNJ2 HCN2 TMSB4X ERG GJA1 HAND2 IGF1 HCN4 KCNE1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling ANGPT2 BIRC5 HIF1AN BNIP3L ANGPT1 PTGS2 BAK1 BAX EPO VEGFA PFKL HEL-S-68p BCL2A1 HEL-S-30 NOS2 BNIP3 TGFA BCL2L1 PDHA1 IGFBP1 SLC2A3 EDN1 IGFBP2 HIF1A EGLN1 HEL-S-133P PMAIP1 MCL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA NTRK2 AKT3 SORT1 KIDINS220 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 TDO2 NMNAT1 HEL-S-90n HAAO KMO KYNU AFMID T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling GSK3B CALM1 CD8B1 DYRK2 CD8A PLCG1 CSNK1A1 ZAP70 GSK3A NFKB1 IL2 PRKCA PTEN PPP3CA ITK FYN NFATC2 NFKBIA LCK CTLA4 DYRK1A PTPN6 PDCD1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO3A1 SLC16A2 SLCO4A1 SLCO1A2 SLC16A10 SLCO1C1 SLC7A5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation TAF5 GTF2B GTF2H2C_2 TAF9 CCNH GTF2E1 GTF2E2 GTF2H2 GTF2F2 POLR2B GTF2H3 POLR2F POLR2G POLR2H ERCC2 POLR2I POLR2J MNAT1 POLR2K TAF13 POLR3B POLR3D TAF7 TAF6 POLR3H TBP POLR3K POLR1A POLR1D HEL-S-28 TAF12 CDK7 POLR2C POLR2A POLR3E ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway SERPINB2 EGFR POLK TGFB1 EP300 MYOF BAX JUN SLC7A5 SRC UGT1A4 IL2 AHRR UGT1A7 JUND TNF CAP2 PTGES3 MGST1 NFE2L2 CDKN1B CES3 UGT1A3 NQO1 CYP1A2 CYP1B1 CDC37 UGT1A1 UGT1A9 IGFBP1 CYP1A1 IL12B HES1 IL12A JUNB AIP ALDH3A1 IFNG IL1B AHR IL17B NCOA1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 ACADS ACSL3 ACADM PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 BATF CD8B1 CD3G STAT3 CD3E CD3D CD8A JUN ZAP70 NFATC1 HLA-DRB1 NFKB1 HLA-A PDCD1LG2 IFNG NFATC3 NFATC2 PTPN11 NFATC4 LCK PDCD1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling HCLS1 CAMK2A RELA GAB2 BRAF VAV1 VAV2 FOXO1 SHC1 PDPK1 MYC CARD11 BCL10 MAPK1 PTPRC FYN MAP2K6 NFATC3 NFATC2 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 RAF1 CD79B CD79A BLNK CD19 PRKCB MAP3K7 STM7 GTF2I CR2 PIP5K1A REL PIP5K1C BLK BTK CD22 LCK GSK3B MAP4K1 MAPK9 MAPK8 CHUK BCL6 PLCG2 CRK IKBKG PLCG1 JUN NFKB1 MAX RASGRP3 CRKL INPP5D LYN SYK PIK3R2 PIK3R1 CDC42 RAPGEF1 CD81 LAT2 DAPP1 PTPN18 TIEG2 PIK3AP1 CBL RPS6KA1 NCK1 GSK3A IKBKB CREB1 MAPK4 RAC1 HRAS GRB2 SOS1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ITPR2 CYP21A2 AGTR2 PLCB2 STAR CALML6 REN CALML3 CALML4 CAMK1 CAMK2G CMA1 ATF1 ATF2 CYP11B2 AGTR1 HSD3B2 CYP11A1 CALM1 CREB3L3 CREB3L4 HSD3B1 CTSG CAMK1D CAMK1G CREB3L2 CREB3 CREB1 CREB5 CAMK2D ATF6B CAMK4 ATF4 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF RAF1 TSC2 STAT3 TSC1 NRAS EREG BTC RHEB TYK2 PTEN AKT3 KRAS SOS2 JAK1 HRAS RPTOR JAK3 MTOR GRB2 TGFA SOS1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKB1 RAF1 RRAS IKBKB CHUK MAPK1 MAP3K14 MAP2K6 TRAF6 MAP3K1 NFKBIA IKBKG SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events FOS ARC PLCD4 NLGN1 5HT1A CRHR1 PLEK PPP3CA CRH HTR2A PRKCB SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 NLRP3 TERF2IP REN TRAF3 TRAF6 SIRT6 RPS6KA1 ECSIT NDUFAF2 NFKB1 IL18 IL6 TERF2 MAVS TNF NLRX1 MITA ACE2 ACAD9 NDUFAF1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4E IFRD1 ADAM10 NR4A3 VEGFA HEL-S-52 IL18 IL1R1 IFNG CYR61 DUSP14 HBEGF JUND EIF4EBP1 GDF8 ANKRD1 MYOG ATF3 IL1A OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CCND2 TSC2 TSC1 PRLR CEBPB RAD51 CDK4 SYNE2 NR1i1 NR5A1 TBP MTOR NR3A2 NCOR1 PGR CDKN1B FSHR ATM FMR1 GJA4 LHCGR FIGLA DAZL GDF9 DMC1 CREB1 ZP3 ZP2 EGR1 SMPD1 PTGER2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG ID2 STAT3 RUNX2 SPI1 IKZF1 IRF4 IRF8 TCF4 CSF1 BATF3 CSF2 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDKN2A ACTL6B EZH2 ACTL6A CDK4 PTCH1 EED SMARCD1 CDK6 SMARCC1 SMARCA4 SMO SMARCD2 ARID1A SMARCC2 SMARCD3 SUZ12 GLI3 ARID1B RB1 H3F3B GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAP3K7 MAPK8 IKBKB CHUK RELA CD40 IKBKG EPHB2 ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CDKL5 MEF2C FRS3 CAMK2A DOK5 KCNN2 DOCK3 KCNA3 NCAM1 ARHG SIRPA SH2B1 RANBP9 MARCKS VAV2 BDNF SRC SHC1 KSR1 PDPK1 EIF4EBP1 PRKAA2 FYN SHC4 YBX1 SHC2 PTPN11 SHC3 NFATC4 NFKBIA EIF4E GRIA2 RPS6 RPS6KA5 GRIA3 RPS6KB1 SQSTM1 ACACB STAT5B PTK2B PTPRF MAPK10 MAPK9 TSC2 MAPK8 EIF2S2 STAT3 CRTC1 MAP3K2 CSNK2A1 RAP1A GRIP1 PIK3R2 PIK3R1 RASGRF1 CYFIP1 GRIN2B IKBKB RAC1 HRAS IGF2BP1 RELA STAT1 CDH2 MAP3K1 CAMK1 GRIN1 CTNNB1 CDK5R1 RPS6KA3 IRS1 MAPK1 MAPK3 MAP2K1 MAPK14 MAP2K2 ADAM17 RAF1 PRKAA1 NCF1 NTRK1 NTF3 NTRK3 PPP2CA TIAM1 EIF2S1 CDK5 GSK3B HEL-S-15 MAP2K5 NGFR EEF2 CASP3 CHUK TRAF6 PLCG1 IKBKG JUN NFKB1 MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 BAD MTOR APC CDC42 NCF2 FOXO3A GABRB3 RPS6KA1 NCK2 NCK1 VAV3 NGF CREB1 FRS2 CNR1 GRB2 SYN1 CAMK4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2L1 BCL2 FADD CASP9 CASP3 BBC3 APAF1 BAX TNFSF6 TNF MAPK12 CASP8 MAPK13 BAD MAPK11 MAPK14 MCL1 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP2C8 PTGS2 CYP2C9 CYP1A2 ALOX15 EPHX3 ALOX12B PTGS1 CYP2C19 CYP3A4 CYP4A11 GPX4 ALOXE3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 MCL1 ZAP70 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLC34A3 ITGB1 EGFR HDAC2 CFTR ANKRD35 EIF4A3 GPR89B AKAP10 SLK SUMO2 MAGOH FURIN NUDT17 HEL-S-76p HLA-B HLA-F HLA-G HLA-E RBCK1 MET SLC22A4 PEX11B CLCN3 BCL2L13 TNFRSF14 FARP2 FLT3 NHERF1 UBE2I POLR3GL CD160 PYM1 CXCR4 PDZK1IP1 POLR3C POLR3F POLR3G SIRT1 MITD1 DDIT4 LAMTOR1 IFNG LCK HFE2 HAMP STAT3 CD3D TXN CCAR2 NFKB1 HLA-A HLA-C PEX19 ZFHX3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR17 P2RY11 HTR1F ADORA2B OR2F1 F2RL2 OR2A4 GPR18 ACKR3 HRH3 ADRA1B ADRA1A PTGFR NPFFR2 RRH GPR174 PTGDR2 GPR173 GPR171 CMKLR2 CMKLR1 GPR37L1 FPRL2 TRHR TBXA2R PTGDR OR1I1 MC2R PTGIR GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 F2RL1 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW CCR8 CCR4 GPR39 OR5F1 GPR34 GPR31 NPFFR1 AVPR1A OR5V1 OPN1MW OR3A2 OPRD1 OR10H1 OR10H3 GPR45 GPR68 CCR3 OR10H2 GPR42 OR2AG1 CHML OPRK1 EDNRB P2RY10 P2RY14 NPY1R GPR52 GPR50 GPR4 GPR15 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 OR2B2 CCR6 HTR1E HTR1D HTR1B NMUR2 NMUR1 OR7A10 OR14J1 MLNR HTR2B PRLHR OR8D2 OR7A17 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 CX3CR1 OR1E2 NPY4R BDKRB2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OPN1SW ACKR4 FFAR1 ACKR2 OR11A1 KPG_010 GPR83 LPAR4 KPG_011 AVPR2 GPER CCRL2 CHRM4 CHRM5 PTGER4 PTGER2 AGTR2 CCR2 GPR75 AVPR1B NMBR CXCR4 C3AR1 PTGER1 PTGER3 GHSR RHO C5AR2 NPY2R FPR1 HTR7 BDKRB1 GPR37 MTNR1A ADRB1 MTNR1B GPR161 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 P2RY1 CHRM1 ADRA2C ADRA2B MGRA ADRA2A MC3R AGTR1 OXTR ADORA2A HTR5A 5HT1A CNR2 CCR7 CXCR5 HCRTR2 HCRTR1 MC4R CHRM2 CHRM3 OR1G1 ADRA1D GPR32 HTR2A FPR2 P2RY6 HTR4 P2RY4 GRPR HTR6 ADRB3 P2RY2 LTB4R EDNRA CCR5 OR1F1 F2R OR2H1 FFAR3 FFAR2 SSTR2 CCKBR FSHR OR3A3 OR10A5 OR3A1 OR1E1 LHCGR ADRB2 IL8RB CXCR1 CNR1 CXCR3 OR2B6 NTSR1 MC1R P2RY13 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK NFE2L2 MAPK8 SP1 MAFF MAP2K1 MAP2K2 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 PHF19 CD40 STAT4 ITGAV HLA-DRB1 MHC2TA SLC22A4 TRAF1 BLK CTLA4 IL2RA IL6ST CCR6 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 COX1 MB HBB XDH NOS2 AOX1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDKN2A EGFR SMAD4 RELA TRAF3 MAPKAP1 NRAS VEGFA IGF1R CTNNB1 PDPK1 CDK4 AKT3 ERBB2 PRKAA2 EIF4EBP1 FKBP1A KRAS RPTOR IRF6 MLST8 TP63 NOTCH2 NOTCH1 EIF4E RPS6KB2 NFE2L2 FGFR2 SESN2 PRKAA1 CSMD3 RPS6 DDIT4 SESN1 RHEB TERT NFKB2 RB1 REL STK11 CCND1 KEAP1 AJUBA TSC2 TSC1 BIRC2 PIK3CA NFKB1 MAML1 CASP8 FAT1 MTOR PIK3R2 PIK3R1 NUMB PIK3R5 CDK6 FADD FGFR1 CDKN1A PTEN RICTOR HRAS TGFBR2 FGFR3 SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism SHMT1 HEL-S-51e PHGDH TYMS SRR PSAT1 DHFR PSPH CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 RELA IFNA21 CASP10 IF1AA9 ISG15 IFNA8 CCL5 CCL4 NFKBIA IL33 NFKBIB POLR3GL IKBKE POLR3C POLR3F ZBP1 POLR3G AIM2 ATG12 POLR2L TREX1 IFNA6 POLR3A RIPK3 IFNA7 RIPK1 CHUK TBK1 IKBKG TRIM25 POLR2F RNF125 POLR2H NFKB1 CYLD ATG5 ADAR POLR2K IL6 POLR3B MAVS POLR3D CASP8 RIGI IFNA2 POLR3H POLR3K POLR1C POLR1D FADD PYCARD CCL4L2 TRADD IL18 IFNB1 IKBKB IL1B CGAS MITA NLRX1 POLR3E IFNA1 IRF3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 CHD3 HBB GATAD2B MTA2 NR2C2 HDAC1 tal-1 HBG2 LDB1 LMO2 HBD BCL11A HBG1 HBE1 GATA1 KDM1A ZFPM1 KLF1 ZBTB7A PPARGC1A MYB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA DPYS TYMP TK1 POLE4 RRM1 RRM2 UCK2 UCK1 UMPS POLR3GL POLR3C POLR3F POLR3G POLR2L TYMS ENPP1 POLR3A POLD3 POLD4 POLE RRM2B ZNRD1 HEL74 ENTPD3 NME2 NME3 CTPS2 CTPS1 POLE2 NME4 POLR2A DCTD POLE3 NME6 NME7 CMPK1 CMPK2 POLR1F UPRT DCTPP1 PRIM2 POLA2 DTYMK DHODH POLR2D NT5M POLR2J3 DUT PNPT1 POLR2J2 POLA1 CAD POLR2B ENTPD1 POLR2G POLR2H POLR2I POLR2J POLR2K POLR3B POLR3D POLR3H ENPP3 POLR3K POLR1A POLR1C POLR1D PRIM1 POLR2C POLD2 POLR3E DPYD GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG SLC5A1 PCSK1 SLC2A2 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 PTGS1 5HT1A FAAH TRPA1 PTGS2 CACNA1H TRPV1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 ETS2 BIRC5 EGF CD81 EGFR STAT3 IGF1 CD63 KDR PTEN IL6 GATA4 HEL-S-102 SPP1 HEL-S-44 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis MEF2C MIXL1 MEF2B KLF6 STAT2 CYP26A1 MEF2D NR2F1 PRLR CEBPA CEBPB EGR2 KLF5 CEBPD LIF GATA3 GATA2 CYP26B1 KLF15 SOCS3 SOCS1 TWIST1 GATA4 SLC2A4 RARA LIPE NR1C2 TRIB3 HIF1A RB1 PTGIS STAT5B GADD45B PCK2 AHR MIF HMGA1 RORA CFD RXRG WWTR1 TGFB1 STAT3 E2F4 SFRP4 DDIT3 SCD GADD45A GH1 FZD1 WNT10B PPARGC1A NCOA1 LPIN1 LPIN2 LPIN3 STAT1 ID3 FOXC2 IGF1 BMP4 FOXO1 INS FAS CTNNB1 NR1C1 IRS1 RXRA IRS4 TNF WNT5B IL6ST NCOR1 MBNL1 HNF1A BMP1 LPL NR3C1 CELF1 ZMPSTE24 LMNA CISD1 DVL1 RBL2 RBL1 WNT1 NR1H3 BMP2 OSM LEP RETN CNTFR GTF3A BSCL2 ADFP NDN BMP3 PLIN1 FRZB IL6 SPOCK1 SP1 UCP1 GDF10 KLF7 PCK1 NCOR2 NAMPT PPARG PNPLA3 CDKN1A CREB1 ASIP SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs LPAR1 MTNR1A PTGER1 PTGER3 GPR50 MTNR1B CNR2 S1PR3 PTGFR TBXA2R PTGDR PTGIR S1PR2 S1PR4 PTGER4 CNR1 S1PR1 PTGER2 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs HTR1D HTR1B HTR1F CHRM2 CHRM3 HTR2B ADRA1D HTR2A HTR4 HTR6 ADRB3 CHRM1 HTR7 ADRA2C ADRA2B ADRA2A ADRB1 ADRA1B HTR5A ADRA1A 5HT1A CHRM4 CHRM5 ADRB2 DRD1 DRD2 DRD3 DRD4 HRH1 HRH2 DRD5 HTR1E ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 AGTR2 TGFB1 REN CTSG CMA1 BDKRB2 ATP6AP2 NR3C2 MGRA BDKRB1 ACE2 CYP11B2 AGTR1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 SELE ITGB1 ITGB7 SELPLG ITGA2 MADCAM1 VCAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation GHRH BTBD9 GHRL STAR HTR2A NPY2R ADA SLC29A1 IL6 HEL-S-2 CHRNB2 UTS2R MRGPRX2 OXTR ADORA2A MTNR1B NLGN1 OXT UTS2 TH NPS NPAS2 FOS DRD1 PTGDR IL18 DRD2 DRD3 DLAT CRH CACNA1I HCRTR2 HCRTR1 PER3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway MEF2C CASP3 NCAM1 CTCF EP300 STAT3 CHD2 SMC3 HEL-S-89n NFKB1 PRNP RXRA MAPK1 FYN MAPK3 TBP HEL-S-269 RFX5 HEL-S-125m BCL2 PAX5 BATF RAD21 FGFR1 SPI1 POU2F2 IRF4 BCL11A CREB1 CASP12 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation TACI TLR4 SMCR8 IFT46 C9orf72 IFT70B WDR26 GPS1 MIEF2 RAB10 RASD1 RANBP9 RMND5A FNIP1 FNIP2 NR1H2 MYO16 MKLN1 GID4 MYO15A DRG2 RPTOR BCL2L11 MLST8 PRKAG2 PRKAB1 IRF8 HEL-S-133P G6PC1 CDC2 MYH2 WWTR1 APP PPP1R14A STAT3 BCL6 BAX YAP1 PARK2 IFT172 BLM IFT74 CLTB GRIP1 ULK1 PRDM1 IFT81 IFT27 IFT25 MED9 RAI1 GPR85 PTEN CLEC16A CARM1 RELA TNFSF13 MYC TNF FOXA1 CRY2 CRY1 PRKAA1 FOXA2 ATG101 TRAF3IP1 RAB8A FLCN IFT52 NR1H3 CFL2 PRKCI PARD3 IFT57 PER1 FLII IFT80 MYD88 RB1CC1 NT5M ARG2 TFEB BIRC2 ROCK1 JUN PARD6B NFKB1 LIMK1 MAP3K14 ARHA MTOR FERD3L HES6 PCK1 ALKBH5 CLTC MAEA DENR CLTA MIGA1 ARMC8 RNF41 TOM1L2 FHOD1 RRAGA PEMT LLGL1 DRC5 SHMT1 CLUAP1 DRC7 DRC8 COPS7A PLD6 RAB39B COPS4 IFT20 COPS6 IFT22 COPS5 DRC1 COPS8 GDI2 CREB1 WDR41 IL1B IFT56 ATPAF2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 LIPT2 LIPT1 GLDC AMT DLD HSCB LIAS GCSH NFU1 BOLA3 ISCU PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PKN2 KDR PDGFRA PDPK1 HGF PRKAA2 SOS2 MET RPTOR TGFA BCL2L11 MLST8 PDGFC FLT3 EIF4E EIF4B EGF RPS6KB2 FGFR2 GYS2 GYS1 RPS6 RPS6KB1 RHEB PIK3R3 G6PC1 JAK3 STK11 MCL1 CCND1 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 IL4 SGK1 PIK3R2 SYK PIK3R1 IL3 IL3RA GH1 MDM2 PKN3 PKN1 PTEN BRCA1 IKBKB RAC1 JAK1 HRAS IFNA13 IFNA14 EGFR NTF4 IFNA16 IFNA17 FLT3LG IFNA10 RELA IFNA21 FGFR4 IF1AA9 NRAS VEGFA FGF10 IFNA8 IL7 CSF1 IRS1 MAP2K1 MAP2K2 HEL-S-125m BCL2L1 TCL1B TCL1A PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 CDC37 TNFSF6 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 GNGT2 RBL2 FGF8A OSMR COL2A1 KIT PHLPP2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD NGFR CASP9 KITLG GHB3 CSF3 CHUK CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 CSF1R NTRK2 EFNA5 EFNA4 CHAD FGF20 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 EFNA3 PCK1 FGF14 EFNA2 PIK3R5 CDK6 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 G6PC2 ITGB4 FLT4 LAMC2 FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 IFNA1 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C TLR4 ANGPT4 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 PRL LAMB2 PPP2R3A EPOR PPP2R2C PRLR PPP2R2B PPP2R2D BDNF EIF4EBP1 GHB2 GHR CSH2 G6PC3 COL6A6 COL6A5 CDKN1B ITGB3 IGF2 ITGA2B CCND3 IFNA6 CD19 LAMC1 IBSP IL6R CCNE2 ITGA1 COL6A1 PCK2 ITGA2 COMP COL4A3 COL9A1 COL9A3 COL9A2 COL4A5 COL1A1 LAMA5 LAMB4 SGK2 THBS1 VTN SPP1 LAMB1 CCNE1 FGF23 TNC FLT1 INSR PDGFA IGF1 IGF1R INS CHRM1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 ATF2 COL1A2 MYB PDGFD BCL2 PRKAA1 PHLPP1 PPP2R2A PPP2R3B PRKCA NTRK1 NTF3 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 NFKB1 GNG13 IL6 GNB2 GNB1 IFNA2 GNB4 F2R GNB3 GNB5 GNGT1 PIK3AP1 CREB3L2 CREB3 CREB1 ATF6B HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis SYT2 HNRNPL CALM1 CAMK2A BCL2 CCND2 PRL NCAM1 RPS6KA5 RPS6KA1 NRXN1 BDNF NRXN3 NRXN2 PRKCA DRD1 NGF CAMKK1 CREB1 CAMKK2 MAPK1 PPARGC1A MAPK14 CAMK4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 RYR1 CCK RYR2 PLCB1 CCKBR DAGLA GNAI1 RYR3 CNR1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PANK2 RB1CC1 TSC2 TSC1 FTL WIPI1 WIPI2 ATG5 ATG14 CP RPTOR MTOR ULK1 PIK3R4 DEPTOR MLST8 WDR45 ACACA DCAF17 C19orf12 ATG3 COASY FA2H PRKAA1 ATG12 RHEB ATG16L1 PLA2G6 AKT1S1 ATG101 ATG2A MAP1LC3A SPTLC1 ATG10 STK11 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P REN CTSG CMA1 PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs AGTR2 TACR1 CCR2 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 CX3CR1 NPY4R BDKRB2 MC3R AGTR1 OXTR AVPR1B NMBR CXCR4 ATP8A1 TACR2 TACR3 CXCR6 TAC4 CCR7 CXCR5 FPRL2 TRHR C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 CCR10 HCRTR1 NTSR2 CCR1 GHSR MC4R BRS3 C5AR1 NPY2R CCKAR FPR2 FPR1 GRPR CCR8 CCR4 EDNRA AVPR2 AVPR1A GNRHR CCR5 OPRD1 BDKRB1 TSHR CCR3 OPRK1 EDNRB NPY1R SSTR2 CCKBR FSHR MC5R LHCGR IL8RB FY CXCR1 CXCR3 NTSR1 MC1R CCR6 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3 RNF8 NIPBL H2AX MDC1 ATM RNF168 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer GLS PYCR2 PSAT1 HEL-S-162eP PFKL PSPH ACLY ENO1 HEL-S-68p PGAM1 HEL-S-30 PAICS PDHA1 MDH2 GOT2 FASN SLC16A3 GLUD1 HEL-S-51e ALDOB TIGAR SDHB ACO2 FH RPIA SUCLG2 HEL-S-133P HK3 HEL107 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 SMAD4 CHUK RELA NR3C1 MAP3K1 MED14 IKBKG NFATC1 NFKB1 IL6 MAP2K3 IKBKB RXRA PPP3CA NR1i1 TNF MAP2K6 MAPK14 NFKBIA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA AKT3 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling MAPK8 KITLG EP300 STAT1 STAT3 GAB2 CRK PLCG1 VAV1 GRB7 SRC SHC1 SH2B2 RPS6KA3 SOCS1 MAPK1 CRKL FYN MAPK3 INPP5D BAD PTPN11 MAP2K1 MAPK14 LYN MAP2K2 TEC PIK3R2 PTPN6 PIK3R1 RAF1 FOXO3A RPS6 CBL GRB10 RPS6KA1 SOCS6 RPS6KB1 MATK PRKCB PRKCA DOK1 KIT STAT5B HRAS BTK GRB2 SOS1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2 UGT1A4 NAT2 CYP1A2 SULT1A1 UGT1A9 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo KLF4 ZFP36L2 SOX8 MXD1 ZFP42 POU5F1 GATA3 GATA2 SIX3 DPPA3 SOX2 TFAP2B IRX5 SOX11 ELAVL1 IRF4 NANOGNB FOXD1 DNMT3L KHSRP MYBL1 ZAR1 ARGFX TCF7L1 DLX2 PADI6 BARX2 LEUTX TPRX1 E2F5 TBX3 DPRX CDX2 ZSCAN4 MACROH2A2 HMGA1 HNRNPAB MTA3 FOXQ1 AQP3 NR3C2 DDIT3 PBX1 SMARCA4 AQP9 ATP1A1 NKX2-1 TEAD4 BATF3 EGR1 MOS FOSB ESRRA ZFP36 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 SCARB1 LDLR PLTP APOE LPL LIPC VLDLR APOA2 DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RPA4 MCM5 MCM6 PRIM2 POLA2 CDC45 RFC2 POLA1 RFC3 RFC4 CDK2 RPA3 RPA1 PCNA MCM2 GMNN POLD3 RFC1 PRIM1 POLD4 UBC POLE ORC6 ORC3 POLE2 ORC2 POLD2 CDC6 MCM7 ORC1L MCM10 DBF4 CDT1 MCM3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways HDAC2 CYP46A1 MBP NR1H2 BDNF EIF4EBP1 PRKAA2 RPTOR DEPTOR BCL2L11 PRKAG1 MLST8 PRKAG2 EIF4E EGF PRKAG3 C1QA RPS6KA5 PRKAB2 RPS6KB1 RHEB PRKAB1 SREBF2 AKT1S1 HMGCS1 ABCG1 PIK3R3 ABCG4 PI3 MAPK10 HAP1 MAPK9 RAB3GAP1 TSC2 MAPK8 TSC1 BAX CASP8 PIK3R4 PIK3R2 PIK3R1 AHI-1 APOE PTEN IKBKB PPARGC1A SIN3A HRAS EGFR SLC12A2 HTT AKT3 MAP2K4 MAPK1 KIF5A MAPK3 MAP2K1 MAP2K2 MAP3K10 BCL2L1 BCL2 RAF1 PRKAA1 HDAC1 NEUROD1 ABCA1 HEL-S-29 REST PIK3CD CYP51A1 CASP3 DHCR7 HMGCR PIK3CA NFKB1 IL6 NTRK2 SP1 GABRG2 BAD BNIP3 MTOR PIK3R5 PIK3C2G PIK3C2A OPA1 PIK3C2B GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 CREB1 GABRA3 GABRG3 IL1B GABRG1 RICTOR SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2 PAPSS2 PAPSS1 SULT1B1 SULT2A1 SULT1A1 SULT1E1 SULT2B1 SULT1C3 SULT6B1 SULT1C2 SULT1C4 HEL-75 SULT1A4 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity MARK1 BAK1 CASP10 MBP FAS CX3CR1 CX3CL1 MFGE8 AXL FCN1 FCN2 C1QB C1QA ITGB3 COLEC11 DIABLO PROS1 TNFSF6 C4B_2 C2 C4BPA C4A C8A HEL-S-62p C3AR1 IFNG MBL2 CR2 CR1 PRKCI PARD3 CYCS C1QC SERPING1 MASP2 MASP1 CD46 CAP1 CFD CASP9 PRKCZ CASP3 TGFB1 PATJ FCN3 APAF1 CFH BAX C4BPB C5AR2 DLGAP5 ATP11A CFI ATP11C C5AR1 SCRIB PLSCR3 PLSCR4 TYRO3 PARD6B LLGL2 PARD6A CRB2 CFP COLEC12 CRB1 PALS1 COLEC10 VTN PARD6G CLU ATP10A C6 C7 DEDD C8G CASP8 C9 ATP8B3 CD59 ATP8B2 CD55 ATP8B1 C1R ITGAM ITGAV ITGAX PLSCR1 HTRA2 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling TLR4 CAMK2A CYP21A2 STAR RELA BRAF CTNNB1 PRKAA2 MAPK1 JUND MAPK3 MAP3K5 TFAP2A MAP2K1 MAPK14 NFKBIA ERN1 BCL2 ACACA RAF1 GJA1 HSD3B1 GNAZ PRKCB GNA11 JUNB TCF4 PRKCA CACNA1H PRKCI PRKCQ GSK3B CASP9 MAPK9 CRHR1 MAPK8 CASP3 GNAI1 TGFB1 PLCG2 PLCG1 TRIM28 NFKB1 JUP IL2 SP1 CXCL8 GNB2 ARHA CRHBP GNB1 KRT1 GNAS IVL CRHR2 GNB3 GNAO1 HSD3B2 KRT14 GNB5 ECE1 CYP11A1 POMC PARP1 FOSL2 FOSL1 ARRB2 SULT2A1 FOS IL18 CREB1 CASP12 CRH FOSB SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety POMC PLCD4 ADRA1A 5HT1A PLEK EEF2K HTR2A PRKCB FMR1 FOS ARC PPP3CA CRH TRPV1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling IRAK1 IRAK2 UBE2V1 IRAK4 PRKCZ MAPK9 TAB3 MAPK8 MYD88 RELA CHUK TRAF6 MAP3K1 PLCG1 IKBKG MAP3K2 MAP3K7IP1 JUN NFKB1 MAP2K3 HEL-S-71 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 PIK3R2 PIK3R1 IRAK3 NFKBIB PELI1 HSPB2-C11orf52 ECSIT MAP3K7 SQSTM1 IL1R1 IKBKB IL1B REL MAPKAPK2 IL1A PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYS DHODH TYMP NT5C3A RRM1 RRM2 TYMS CAD ABAT UMPS OTC RRM2B GLS2 HEL74 DPYD OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL1 FADS1 ELOVL5 SCD5 ELOVL6 FASN ELOVL3 FADS2 SCD ACSL1 ELOVL2 FACL4 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 CS PC SDHA HEL-S-26 OGDH ACLY FH DLD SUCLG2 DLAT HEL-S-32 HEL60 PCK1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36B IL36RN STAT1 IL36G IL1F10 GATA3 SOCS3 CSF1 SOCS1 MAPK1 BCL2L11 IL37 POLR2L ANAPC1 ZNRD1 IL1R1 IL23A POLR1F ARF6 PLCG2 POLR2F POLR2H IL2 POLR2K IL6 POLR1A POLR1C POLR1D CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 TTL IL1RL2 NT5DC4 IL1B CSF2 RAC1 IL1RN MERTK CXCL13 GRB2 IL36A IL1A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling EGFR FLT1 RELA INSR FGFR4 BRAF PML CSNK1A1 FOXO1 IGF1R SRC KDR KSR1 SHC1 PDGFRA GAREM2 CTNNB1 MYC AKT3 MAPK1 SOS2 KRAS MET MAPK3 RPTOR MAP2K1 NFKBIA DEPTOR MAP2K2 MLST8 FLT3 ZBTB16 PYGO1 RAF1 BCL9 RARA FGFR2 RUNX1T1 LEF1 EPHA2 RHEB AKT1S1 NR1C2 IL6R NTRK1 TCF3 KIT WNT1 REL CCND1 GSK3B PIK3CD NGFR TSC2 RETN CHUK TSC1 STAT3 IKBKG AXIN2 JUN PIK3CA NFKB1 JUP CSF1R NTRK2 IL6 LRP5 LRP6 ULK2 MTOR APC TTI1 SALL4 FGFR1 FLT4 MDM2 FOS CDKN1A PTEN IKBKB HRAS GRB2 NFKBIE SOS1 FGFR3 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma CDKN2A PAK1 BAK1 NRAS BRAF KDR CDK4 AKT3 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC2 PTPN11 MAP2K1 PDE5A MAP2K2 RAF1 HEL114 E2F2 DDB2 PIK3R3 RB1 KIT GADD45B GADD45G CCND1 PIK3CD POLK CALML6 ARAF EXOC7 BAX CALML3 CALML4 PIK3CA ARHA BAD GADD45A PIK3R2 PIK3R1 CALM1 CDK6 E2F3 RHOB NF1 MDM2 GRM3 PREX2 CDKN1A PTEN RAC1 HRAS GRB2 SOS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia RELA NRAS BRAF PML CEBPA MYC AKT3 EIF4EBP1 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 FLT3 ZBTB16 RAF1 RPS6KB2 RARA RUNX1T1 RUNX1 SPI1 LEF1 MPO RPS6KB1 NR1C2 CCNA2 PIK3R3 TCF7L2 TCF7L1 KIT STAT5B PER2 CCND1 PIK3CD CHUK STAT3 ARAF IKBKG PIK3CA NFKB1 JUP CSF1R BCL2A1 BAD MTOR PIK3R2 PIK3R1 IL3 PIM1 PIM2 ITGAM CEBPE FCGR1A IKBKB CSF2 HRAS GRB2 SOS1 CD14 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TEDC1 TEDC2 IFT46 FBF1 KATNB1 IFT70B TUBD1 KIF3B CEP76 MIB1 TUBE1 KIAA0753 CPLANE2 SASS6 CEP162 OFD1 CIBAR1 CEP44 CEP20 DYNC2I2 CEP19 DYNC2H1 DYNLT1 DYNLT2B TRAF3IP1 DYNC2LI1 IFT52 KIF3A TMEM107 BBS9 BBS7 IFT57 RABL2B BBS5 BBS4 IFT140 DNCL1 IFT80 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 IFT172 TMEM216 WDPCP IFT74 CEP104 CEP192 ARL6 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 SCLT1 IFT81 FUZ TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP97 IFT27 CC2D2A CLUAP1 ARMC9 IFT25 RPGRIP1L PIBF1 IFT20 CPLANE1 TMEM231 TMEM17 TTC23 C2CD3 B9D1 CBY1 IFT56 RAB23 EFCAB7 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 CCDC41 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis GSK3B ATP7B SLC31A1 ATP7A APP CASP3 COX17 MT2A SLC31A2 FOXO1 COX11 JUN COMMD1 MT4 MT3 PIK3CA ATOX1 MT1A MTF1 PRNP MT1F SP1 MT1G MT1B XAF1 STEAP1 STEAP2 MT1E HEL-S-44 CCS APC STEAP4 ADAM17 ADAM10 FOXO3A MDM2 STEAP3 PTEN ADAM9 CCND1 SLC11A2 BACE1 SCO1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence HMGA1 SLC2A4 MDH2 PARP1 GOT2 ELAVL1 NAMPT CCL27 PRKAA1 RELA SIRT1 SIRT3 IL6 IL1B SIRT5 HEL-S-32 NMNAT2 SIRT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 HBA2 HBE1 GATA1 HBB HBZ tal-1 HBG2 LDB1 LMO2 HBD RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MCM6 TTK CDC45 RRM1 RRM2 TOP2A DHFR WEE1 SUV39H1 HMGB1 CDK4 MYC CDK2 MAPK13 RPA3 SMC2 RPA1 NPAT HLTF PLK4 CCDC6 RAF1 CDKN1B RBBP7 HDAC1 CCND3 TYMS E2F2 PRMT2 POLD3 SMC1A CCNA2 CCNE2 POLE TFDP1 CCNB2 RB1 CCNB1 RBBP4 POLE2 CDC2 CCND1 CDT1 CHEK1 FAF1 CDC25B POLA1 SMC3 MSH6 RFC3 RFC4 BARD1 FANCG SAP30 HMGB2 PCNA PRKDC TFDP2 CDK6 E2F3 MDM2 CCNE1 H2AZ1 RBP1 ZNF655 SKP2 PRIM1 CDKN1A SIN3A MCM7 ORC1L MCM3 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA MMACHC MMADHC TCN2 MTR CD320 TCN1 CUBN CBLIF OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy COL1A1 COL3A1 RELA STAT3 RUNX2 FGFR4 RELB CTGF CEBPB ACAN VEGFA JUN PIK3CA KDR COL10A1 NFKB1 AKT3 MAPK1 JUND SPP1 MAPK3 VHL SOX9 FOSL2 FOSL1 FGFR2 FGFR1 CNMD P4HTM GANC DDR2 IBSP JUNB FOS NTRK1 PRKCA LAMTOR1 HIF1A NGF COL2A1 FOSB FGF23 FGFR3 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 ST3GAL5 ST3GAL1 NEU3 B4GALNT1 NEU4 HEXB HEXA ST8SIA1 ST8SIA6 SIAT4C B3GALT4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 FOXL2 BNC1 NR5A1 WT1 AMH DCAF17 ATG9A CYP17A1 NBN LAMC1 ZAR1 ALOX12 STAG3 SLX4 BLM FANCM FANCL WRN FANCA FANCC HSD17B4 HSD17B1 RFWD3 NUP107 ERAL1 PRDM1 SALL4 ATM BMPR1A FMR1 BMPR2 BRCA2 POLR2C PCCA PCCB STAR BMP6 RAD51 NR3A2 TP63 NOTCH2 AMHR2 LMNA PRORP ANTXR1 EIF2B1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 EIF2B2 PREPL MSH4 NOBOX KHDRBS1 AARS2 EIF2B5 AIRE PPM1B HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 TGFBR3 HROB LHX8 MCMDC2 MCM9 ELAVL2 BMP15 POLG LARS2 C1orf146 MRPS22 SIX6OS1 HAX1 PSMC3IP RECQL4 CCDC185 MGME1 C10orf2 MND1 GNAS CENPE POLR3H NLRP11 XPNPEP2 SPATA33 MST1R FSHR FIGLA DAZL CLPP GDF9 DMC1 ZP3 PGRMC1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 PLCB1 RPP38 PRKCB SPHK1 SGMS2 PRKCA CDK4 CDKN1A SGPP1 TERT RB1 UGCG CDK2 MAPK1 S1PR2 SPTLC1 GLB1 S1PR5 S1PR1 DEGS1 MTOR KDSR MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 H2AX CDKN1A MYC CDKN1B CREB1 CCND3 CCNE1 ATM RAD52 CCND1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3C8 EZH2 SET SUV39H2 SUV39H1 SETD2 EHMT1 H3C15 EED KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L EZH1 KMT2C SETD7 PRDM2 KMT2A SMYD2 KMT5B SMYD4 SMYD3 H4C7 H4C9 MLL2 SETDB1 HIST1H4L KMT5C SMYD1 SETD1B SETD1A SETDB2 SETMAR AEBP2 H3F3B ASH1L SETBP1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DICER1 DROSHA RAN TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer MMP9 CDKN2A EGFR TYMP ARAF NRAS BRAF VEGFA SRC THBS1 RASSF1 CDK4 MYC CXCL8 ERBB2 HBEGF MAPK1 KRAS MAP2K1 MAP2K2 PIK3R2 PIK3R1 EGF RAF1 RPS6KA5 MDM2 CDKN1A RB1 MMP2 DAPK2 HRAS UPK3A CCND1 FGFR3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN HIF1A VEGFA VEGFB VEGFC HES1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX14 COA6 COX1 CSRP2BP PET100 FAM36A COX10 CMC1 TMEM177 PNKD COX17 SMIM20 COX7A2 COX11 COX7B COX4I1 SURF1 COA3 COX6A1 COX8A COX2 COX6B1 COX7C COX3 COXFA4 COX5A COX19 COX16 COX18 TACO1 HIGD1A PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway HEL70 RDX ARHA SEPTIN2 MYL2 RAB35 KIF23 EZR OCRL EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects RGS16 PRL KLF2 CXCL12 ERBB4 MYB 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MEF2C PRL ASCL1 SEPTIN2 MROH2A DGKD HJURP ERFE KLHL30 THAP4 RRAGB ACKR3 RRAGD AGAP1 RAMP1 OR6B3 TRPM8 OR6B2 GAL3ST2 MTERF4 RAB27A COPS9 GBX2 SNED1 NFKBIA RTP5 RNPEPL1 PRH MYOG ING5 FARP2 SEPT6 HEL-S-28 KIF1A ILKAP AQP12B AQP12A AGXT DUSP28 CXCR4 GABARAPL2 ANO7 OTOS RPS6 ITGB3 GYS1 ARL4C USP40 ARF5 ASB18 CENPA CYTH2 SPP2 D2HGDH IRF8 ANKMY1 CYTH1 MLPH CAPN10 RAB17 ASB1 ARF1 HAMP CXCL12 TWIST2 UBE2F CALCRL UGT1A3 RAC1 NEU4 CXCL11 SH3BP4 UGT1A8 EGFR TRAF3 PDX1 PDGFA TNF DISC1 UGT1A10 BOK UGT1A1 UGT1A9 ABCA1 HES1 MAP1LC3A TRAF3IP1 MAP1LC3C EEF1A1 PER2 MYOD1 CALCA DKFZp762B153 DTYMK MAP4 JUN UGT1A4 GABARAPL1 UGT1A7 GABARAP SEPTIN4 HES6 GPC1 PDCD1 CALM1 RRAGA IL13RA1 COPS8 IL1B NEDD8 NDUFA10 PPP1R7 ITPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 ZEB2 HDAC2 ELF3 TGFB1 SUZ12 FOXC2 HDAC1 SIRT1 EZH2 SNAI1 SNAI2 SUV39H1 TCF4 KDM1A PRRX1 TWIST1 KLF8 GSC2 SIX1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway CPT2 KLK15 CYP8B1 PLTP FABP1 ACADM SLC27A1 EHHADH UGT1A9 DBI NR1C1 CDK4 MYC APOA5 RXRA NR1H3 APOC3 CPT1A CYP4A11 CDC2 CYP7A1 CCND1 APOA2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 CYP2A6 UGT1A10 CYP1A2 SULT2A1 CYP1B1 SULT1A1 SULT1E1 CYP1A1 CYP2E1 UGT1A4 UGT2B15 CYP2C19 CYP3A4 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2C8 CYP2J2 COX5A CYP2C9 HEL-S-22 COX8A EPHX2 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 HEL-S-68p H2AX H3F3B STAT3 KHK HEL-S-30 MYL2 SNAP23 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GTPBP4 GJB6 ITGB1 CCND2 LAMA5 NCAM1 INHBA RUNX2 PDGFA SNAI1 BMP4 SHH EDAR NFKB1 PDGFRA CTNNB1 MYC LRP5 PTCH1 TP63 SMO FGFR2 FZD1 LEF1 TNLG7C CCND1 FOXI3 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis IL3RA TF GDF11 HBB KITLG EPOR EPO TNFSF6 CD79A HBG2 HBD HBG1 HBA2 HBE1 GATA1 FAS GATA2 CD34 PTPRC KIT TFRC HBZ IL3 ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MMP9 CREBBP ANGPT1 FGFR2 FLT1 FGF2 VEGFA PLCG1 SRC PIK3CA KDR PDGFRA HIF1A MAPK1 SMAD1 MAPK14 TIMP3 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 MAPK10 MAPK9 MAPK8 CRP ACLY SLC27A2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 G6PC3 PRKAG1 PRKAG2 ACACA PRKAG3 PRKAA1 G6PC2 PRKAB2 PRKAB1 ACACB G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC CUL4A ERCC5 POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 GTF2H5 CUL4B ERCC2 MNAT1 RBX1 RPA3 RPA1 ERCC1 PCNA CETN2 CDK7 POLD3 RFC1 POLD4 DDB2 POLE LIG1 POLE2 POLD2 POLE3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL5 ACSL3 CD36 FABP1 FABP9 FABP4 FABP5 DBI FABP6 SLC27A4 ACSL1 FABP2 ACSL6 FACL4 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL10 TMPRSS2 IL2 IL6 IL7 CXCL8 IL1B TNF ACE2 CCL2 IL2RA CCL3 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects GSK3B IRAK1 CAMK2A CSNK1D MAP2 ASMT SULT1A1 TRAF6 FOXO1 NFKB1 CSNK1E CYP2C19 ACHE MAOA ECE1 CALM1 ADRB1 MTNR1A CRY2 MTNR1B CRY1 APOE CYP1A2 CYP1B1 SIRT1 CYP1A1 AANAT EDN1 PRKCA PER2 PER1 PER3 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB4 MMP9 PIK3CD PLCB1 PLCB2 STAR NRAS KISS1R KISS1 BMP15 PIK3CA NFKB1 MAPK1 KRAS MAPK3 AMH MAP2K1 MAP2K2 CYP11A1 RAF1 ARRB2 FSHR HSD3B1 PRKCH PRKCB PRKCE PRKCA GDF9 PLCB3 HRAS PRKCQ THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis ADCY3 ADCY1 ADCY8 ADCY6 RPS6KA2 NRAS KDM3A HEL-S-7a KDM1A RPS6KA3 PRKG1 MAP2K3 PRKAA2 SOS2 MAPK12 KRAS MAPK13 MAP3K5 ATF2 RPTOR MAPK11 MAPK14 PRKAG1 MLST8 PRKAG2 SMARCD1 SMARCC1 ACTG1 CREB3L3 SMARCD2 RPS6KB2 PRKAG3 CREB3L4 SMARCC2 PRKAA1 SMARCD3 RPS6KA6 RPS6 LIPE PRKACG ARID1B PRKAB2 RPS6KB1 RHEB CPT1C PRKAB1 AKT1S1 ADCY9 ACSL1 ACSL6 FACL4 CPT2 ACSL5 ACSL3 TSC2 TSC1 ACTL6B SIRT6 SLC25A29 ADRB3 BMP8A BMP8B ACTL6A ZNF516 PLIN1 MGLL KDM3B UCP1 PRDM16 CPT1A GNAS FGF21 MTOR PNPLA2 SLC25A20 GCG SMARCA4 ARID1A PPARG FGFR1 PS1TP5BP1 RPS6KA1 CREB3L2 CREB3 CREB1 FRS2 PPARGC1A CREB5 CNR1 DPF1 HRAS DPF3 GRB2 SMARCE1 SOS1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy LPIN1 LPIN2 LPIN3 ITGB4 BSCL2 CAVIN1 INS PIK3CA HMFN0839 DGAT1 HIF1A IRS1 FYN GRB2 DGAT2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation RORA KLF4 CEBPA CEBPB TLE3 EGR2 FOXO1 KLF5 CEBPD INS GATA3 GATA2 EVI1 KLF15 KLF2 DDIT3 NR2F2 CTNNA1 ZNF423 RARA PPARG WNT10B NR3C1 IRF4 TCF7L1 CREB1 NR1H3 STAT5B IRF3 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PLCB4 MYL3 ADCY3 ADCY1 PLCB1 ADCY8 PLCB2 ADCY6 MYL1 NR3C1 ADRB2 MYL4 PLCB3 CREB1 ADCY9 PRKAR1B PRKAR1A MYL2 GNAS STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 STAR HSD3B1 CYP17A1 HSD17B1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COL1A1 MBTPS1 PPIB PLOD2 MIA3 LRP5 TMEM38B COLGALT1 MBTPS2 IFITM5 LRP6 CRTAP P3H2 P3H1 COL1A2 PLOD1 ADAMTS2 LOX P4HA1 BMP1 TNFSF11 FZD1 SP7 TNFRSF11B P4HA2 TNFRSF11A WNT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS5 CERS1 CERS2 tmp_locus_29 B4GALNT1 B4GALT1 CERS3 CERS6 CERK SGMS1 SPHK1 B3GNT5 SGMS2 A3GALT2 DGAT1 UGT8 UGCG SPTLC1 A4GALT KDSR MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B FGFR2 AXIN1 MAP3K1 ROCK1 FRAT1 CTNNB1 FOXL2 MAPK1 ARHA WNT4 SRY MAPK11 GADD45G FGF9 SOX9 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling NOD2 IL2RG TGFB1 HLA-DMA IL10 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL4 IL5 IFNG TNF MAF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IF2B1 TLR4 RORC STAT1 STAT3 STAT4 IL12RB1 IL12B TYK2 IFNG IL23A IL17F CSF2 TNF STAT5B IL17A ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA2 MAPKAP1 SHC1 PDPK1 CYP3A4 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 RPTOR SHC3 PRKAG1 MLST8 PRKAG2 SLC2A4 EIF4E RPS6KB2 PRKAG3 CBLC RPS6KA4 RPS6KA6 GYS1 RPS6KA5 PRKAB2 MAP3K8 RPS6KB1 MAP3K6 RHEB MAP3K7 PRKAB1 SREBF2 PIK3R3 G6PC1 MAP3K12 HEL-S-31 FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 EXOC7 MAP4K3 MAP3K2 HEL-S-42 ABCG8 ABCG5 SCD CYP7A1 PIK3R4 SESN3 PIK3R2 PIK3R1 TRIP10 RAPGEF1 MAP3K13 GSK3A HRAS INSR MAP3K1 FOXO1 INS RPS6KA3 IRS1 MAP2K3 RXRA IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 MLXIPL FASN PRKAA1 LPL CYP2B6 ANGPTL8 NR1H3 THRA GSK3B PIK3CD MAP2K5 SLC16A2 CRK SLCO1C1 PIK3CA MAPK7 NR1A2 MAP3K14 MTOR PCK1 FOXO3A PIK3C2G PIK3C2A FBP1 CBL RPS6KA1 MAPK6 MAPK4 RICTOR SOS1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape MCM5 MCM6 CAMK2A IFT46 CREBBP IFT70B HDAC2 WDR26 RANBP9 RMND5A RAB14 XPNPEP3 MKLN1 GID4 CTBP2 DYNC2I2 NEFL TFAP2B DYNLT1 DYNLT3 DYNLL2 NDUFA5 DYNLT2B RB1 MCM10 MYL6 DYNC1H1 DYNLRB2 EXOSC4 DNCL1 EXOC8 TBC1D4 EXOC7 YAP1 EXOC4 EXOC3 EXOC6 IFT172 MSH2 EXOC5 EXOC2 DOCK5 EXOC1 IFT74 PSMD7 TFAP2C SNAP29 DGKE UBE2D2 MCM2 SMC4 APMAP IFT81 TIPRL ERF ARL8B INTU USH1C CEP97 DDX5 HEL-S-296 IFT27 CDH23 NUP88 IFT25 AAR2 PSMD12 CTSA UBE2H TFAP2D HEL-S-91n TFAP2E PSMD13 RHBDD2 EXOC6B CNOT10 GDI1 LSM4 EHD3 CNOT1 WNK1 LCN2 RANBP10 RAC1 UQCC GLB1 ZMYND19 MYL6B RPGR TMED1 GLA DFNB31 NINL RBM14 PSMC6 NUDC ECHS1 PSMC4 CNOT6L NUP133 EIPR1 RAB3IL1 HEL113 ARFGAP3 RABEP2 CD2BP2 NME8 MAPRE2 CEP170 CCDC40 IFT70A ANKS3 VPS4A RAB21 RQCD1 RMND5B WEE1 DNPEP PGRMC2 VAPB BBIP1 GID8 CTNNB1 NEF3 YPEL5 DCAF7 TFAP2A HDAC1 MFAP1 PAFAH1B1 POM121 EIF5B TRAF3IP1 DVL3 RAB8A IFT52 BBS9 BBS7 IFT57 SNRPB2 BBS5 CEP290 IQGAP3 ACSL3 BBS4 IQCB1 IFT140 IFT80 LZTFL1 IFT43 MCM9 HEL-S-47e CBS NFKB1 EFHC2 STOM DYNC1LI1 APC BBS2 NEK8 BBS1 CALM1 MAEA ARMC8 FUZ TTC8 IQGAP1 MKS1 CLUAP1 COPS7A COPS4 IFT20 COPS6 IFT22 SSNA1 COPS5 COPS8 RALB CDR2 H3F3B NDUFA9 HTRA2 IFT56 MCM7 LRPPRC MCM3 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis OXCT1 ACAT1 HMGCL BDH1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members GSK3B PIK3CD TSC2 TSC1 MAPKAP1 IKBKG FOXO1 PIK3CA PARP3 AKT3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 MLST8 PARP2 PIK3R5 PARP1 PHLPP1 PIK3C2G PIK3C2A SIRT1 PIK3C2B ATM PIK3R3 RICTOR STK11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC2 TSC1 PRR5 MAPKAP1 HMGCR RRAGB RRAGD DDIT4L PRKAA2 EIF4EBP1 FKBP1A RPTOR ULK2 MTOR ULK1 PRKAG1 MLST8 PRKAG2 CDC42 PRKAG3 PRKAA1 RRAGA DDIT4 PRKAB2 RPS6KB1 IDI1 RHEB PRKAB1 AKT1S1 PRKCA RAC1 RICTOR EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host TLR4 ITGB1 IRF7 CREBBP EP300 CAV3 NEDD4 VAV2 SOCS3 HLA-B HLA-F HLA-G HLA-E HLA-DRA FLNA VPS11 VPS39 VPS16 AXL IKBKE VPS18 CLEC4M VPS33A ITGB3 ICAM2 RFC1 VPS41 PIK3R3 C1QBP MBL2 ITGA1 ITGA2 SCIN ITGA4 HLA-DRB5 HLA-DMA RAB7A TYRO3 HAVCR2 HLA-A IL4 CLTB CTSL HLA-C ACTN1 ACTN4 PIK3R2 PIK3R1 EIF2AK2 RAC1 MERTK IRF3 HLA-DQA2 HLA-DQA1 EGFR PAK1 RELA STAT1 VPS4A IGF1R HLA-DRB1 MFGE8 CLEC10A ICAM3 MAPK1 HLA-DOA HLA-DOB MAPK3 KPNA1 BST2 CD300A TFAP2A TIMD4 TSG101 CLEC6A RAB5A ASGR1 CD209 HAVCR1 ADAM17 HLA-DPA1 HLA-DQB2 RAB9A HLA-DQB1 ACTG1 HLA-DMB DAB2IP HLA-DPB1 FOLR1 NFKB2 NPC1 REL TIAM1 EIF2S1 RASA2 PIK3CD RELB TBK1 PIK3CA NFKB1 CAV2 ARHA RIGI CLTC CDC42 FLNB CLTA PRKRA IQGAP1 RHOB PS1TP5BP1 ITGAV CLTCL1 ITGA6 NPC2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAPK8 STAT3 MYEF2 JUN PRKCB EDN1 PRKCE FOS MAP2K3 GATA4 PPP3CA MAPK1 ARHA RAC1 CTF1 CAMK2D MAPK11 MAPK14 NFATC4 IL6ST FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 CPT2 ACSL5 ACSL3 ACAT1 ACADM DLD HEL-S-49 CPT1A ACADVL LIPC ACADL PNPLA2 SLC25A20 ACADS CHKB HADHB LPL GCDH LIPF LIPE CRAT ACSS2 GPD2 DECR1 ACSL1 ACSL6 FACL4 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling MEF2C MEF2B ITGB1 CDKN2A KLF4 MEF2D SRC LAMTOR3 SHC1 EIF4EBP1 HDAC7 FYN PTPN11 NFKBIA RHOD ELAVL1 CDKN1B RPS6 RPS6KB1 PXN TCF4 PIK3R3 CCND1 CD44 MAPK9 MAPK8 STAT3 KAT5 IL2 CXCL8 PIK3R2 PIK3R1 MMP7 TJP1 IKBKB RAC1 EGR1 HRAS SERPINB2 BIRC5 EGFR PAK1 PTGS2 RELA SLC9A3 VEGFA FOXO1 CTNNB1 CLDN1 MYC IRS1 MAPK1 KRAS MAPK3 ATF2 MAP2K1 MAPK14 MAP3K11 BCL2L1 RAF1 ARHGEF28 GAS PRKCH TFF2 PRKCE PRKCA KIT PRKD2 PRKCQ PRKD1 BMP2 GSK3B CASP3 CHUK CRK PLCG1 BIRC2 ROCK1 BIRC3 JUN PIK3CA NFKB1 SP1 ARHA HDC BAD MTOR CDC42 ANXA2 YES1 CCKBR ARRB2 PPARG FOXO3A RHOB FOS CDKN1A CREB1 GRB2 SOS1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 DNAJB1 CRTC2 CREB1 SIK1 HDAC7 GNAS SIK3 SIK2 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 CD68 LYZ CD163 F3 CD14 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer GSK3B RB1CC1 TSC2 MAPKAP1 TFEB NRAS FOXO1 PIK3CA EIF4EBP1 KRAS BAD RPTOR MTOR ULK1 PIK3R2 PIK3R1 MLST8 CDKN1B FOXO4 FOXO3A GRB10 RHEB PIK3R3 PTEN RICTOR HRAS GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CCK VIP SCT PGA3 PGC PGA5 MUC6 GAS CBLIF MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3CD PLCG2 NCKAP1L VAV1 VAV2 TREM2 PIK3CA TREM1 LAT LYN PIK3R2 SYK PTPN6 PIK3R1 CYBB ITGAM NCF2 C1QB C1QA PIK3C2A RAC3 NCF1 NCF4 FCER1G VAV3 PIK3R3 FCGR1A CYBA RAC1 ARPC1B SIGLEC7 TYROBP C1QC MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 STK11 CTDSP1 STRADB GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P PFKP HEL-S-30 PPM2C 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 TRAF2 ATG16L1 ATG101 GABARAPL1 GABARAP RB1 TNF PTK2B MAP3K5 ULK1 WDR45B TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NR1D1 SMAD2 STAT1 TGFBR1 ZAP70 TYK2 GATA3 IL27 SOCS3 RXRA MAPK1 LAT MAPK14 NFKBIA CRY1 RARA RUNX1 IRF4 NFIL3 IL6R IFNG HIF1A IL23A IL17F AHR PRKCQ LCK PER1 IL17A IL27RA IL2RA IF2B1 IL23R RORC RORA MAPK8 CD3G IL-21 TGFB1 CD3E HLA-DMA STAT3 CD3D TBX21 IL21R PLCG1 IFNGR1 JUN NFATC1 FOXP3 NFKB1 IL2 IL4 IL6 MTOR FOS IKBKB PPP3CA IL1B JAK1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RBP3 RDH11 RDH8 RHO RBP1 RDH5 OPN1LW RLBP1 RPE65 RDH10 OPN1MW RDH12 OPN1SW LRAT ABCA4 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCB4 PI4K2B PIK3CD PLCD3 TPTE2 PLCB1 PLCD4 IPMK PLCB2 FIG4 PI4KB PIP4K2A PLCG2 PLCG1 PIK3CA INPP5D PI4K2A INPP5E PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR8 INPP4A STM7 INPP4B PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SACM1L OCRL PIKFYVE MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 FST FGFR2 RBFOX2 CBX2 SOX8 EMX2 AMHR2 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 INSL3 WT1 WNT4 SRY MAPK11 RSPO1 AMH FGF9 SOX9 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 FIS1 MIB1 OPA1 BAX MTFP1 MFN2 BNIP3 MFN1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 PFKM HEL-S-68p PGAM2 HEL-S-133P GPT HEL-S-49 HEL-S-30 HEL-S-87p HEL-S-162eP FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 ORAI1 KL DMP1 CYP24A1 FGFR2 ALPL FAM20C SLC34A1 ROS1 GALNT3 PTH ENPP1 NFKB1 CDKN1A NFKB2 CYP27B1 SPP1 CCND1 CYP11B2 FGF23 FGFR3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling ADCY3 ADCY1 ADCY8 ADCY6 STAT2 GNG3 GNG2 GNG5 CCR2 GNG4 GNG7 VAV1 GNG8 VAV2 CCL11 SHC1 c-fgr CX3CL1 CCL5 CCL19 CCL7 SOS2 CCL28 SHC4 SHC2 CCL4 SHC3 NFKBIA CCL1 NFKBIB CCL15 CXCR4 CXCR6 PRKACG PXN PIK3R3 STAT5B PTK2B CCR10 JAK3 CCR1 XCR1 GNAI1 CXCL12 STAT3 WAS CCR8 GNAI3 CCR4 RAP1A CRKL CCR3 LYN PIK3R2 PIK3R1 IKBKB RAC1 HRAS CXCL13 CXCL11 CXCL14 CCR6 PLCB4 PLCB1 PLCB2 PAK1 RELA STAT1 BRAF NRAS ADRBK1 PPBP CX3CR1 CXCL3 AKT3 MAPK1 KRAS XCL1 MAPK3 MAP2K1 CCL17 CCL20 CCL25 CCL24 CCL22 RAF1 CCL21 CCL27 PF4 CCL26 NCF1 PRKCB GNG10 CCR7 CXCR5 GNGT2 ADCY9 TIAM1 PARD3 GSK3B PIK3CD PRKCZ GRK5 CHUK GRK4 WASL PREX1 CRK ELMO1 IKBKG ROCK1 GRK1 ROCK2 DOCK2 GNG12 PRKX GNG11 PIK3CA NFKB1 GNG13 GNB2 GNB1 ITK GNB4 CXCL5 GNB3 GNB5 CDC42 PIK3R5 ARRB2 FOXO3A GNGT1 CXCL16 VAV3 IL8RB PLCB3 CXCL9 CXCR3 CSK GRB2 SOS1 CCL3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 CYFIP1 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP9 EGFR SMAD2 COL1A1 SMAD4 FLT1 RELA TGFBR3 RELB CHD2 CTGF SNAI1 VEGFA SNAI2 TGFBR1 NRP1 SRC KDR NFKB1 PLXNA2 HGF AKT3 PLXNA1 PLXNA4 CDK2 MAPK1 MAPK3 MET COL1A2 MAP2K1 MAP2K2 SEMA3A EGF CDKN1B CCNE1 GSK3A CCNE2 PECAM1 NFKB2 MMP2 RAC1 REL TGFBR2 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CDKN2A DOCK1 HGF EIF4EBP1 RPTOR PTPN11 CDKN1B HSD3B1 HSD17B3 ETV4 HSD17B7 CYP17A1 RHEB PXN RB1 PTK2B CDC2 CCND1 CHEK2 CHEK1 MAP4K1 TSC2 MAPK8 TSC1 STAT3 BAX CDC25B MSH6 MSH2 BLM ACTL6A CPN1 RAP1A KLK3 BARD1 CASP8 CRKL HSD17B4 HSD17B1 HSD3B2 PLK1 RAPGEF1 SMARCA4 ARID1A F13B NOXA1 MDM2 ATM ATR PTEN BRCA1 JAK1 HRAS ERG SMAD2 PAK1 STAT1 MRE11A RAD50 CDK4 MYC CDK2 MAPK1 MAPK3 ATF1 MAP2K1 MAPK14 MAP2K2 FOXA1 BCL2 SMARCD1 SMARCC1 RAF1 SMARCD2 SMARCC2 SMARCD3 ARID1B FKBP5 HSD17B2 CDKN2B SPRY2 CASP9 CASP3 ACTL6B CRK EIF4E1B JUN PIK3CA SP1 SPRY1 SPINK1 BAD MTOR PRKDC FOS CDKN1A RICTOR GRB2 SOS1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR FASN PRKAA1 SIRT1 HMGCR ABCA1 SIRT6 SREBF2 HMGCS1 NR1C1 NR1H3 PPARGC1A MED15 SCD MTOR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK1 IRAK2 MAPK8 MYD88 TGFB1 RELA CHUK TRAF6 MAP3K1 MAP3K7IP1 JUN NFKB1 IL6 MAP2K3 TNF MAP3K14 MAP2K6 MAPK14 NFKBIA IRAK3 ECSIT MAP3K7 IFNB1 IL1R1 IKBKB IL1B IL1RN IFNA1 IL1A FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR3 S1PR4 S1PR5 HEL-S-171mP MS4A1 S1PR1 BTK EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3 NR1D2 G0S2 PSMA4 KLF9 HLA-DMA HEL-S-22 CEBPB PPP1R3C DAZAP2 BTG1 TOB1 STBD1 CLDN5 SUMO3 ERC2 RBPMS CRY2 ZFR ETV6 AAG1 CRY1 HEL-S-72p MYF6 SUMO1 UCP3 IDI1 NCKAP1 GSTM3 PIGF PURA QK3 PER2 H2BC15 PER1 VAPA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 IKBKE IFNB1 MAVS TRAF3 RIGI TRAF6 TBK1 IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CDH17 SCEL PLA2G10 SPRR1B TSPAN8 FAM83A CYP3A7 DHRS9 TNS4 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 KRT20 LGALS4 VSIG2 S100A2 AGR2 AGR3 TFF2 CST6 FAM3D REG4 KRT6C SERPINB3 BTNL8 KRT7 GPR87 ANXA10 LYZ LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 AREG KRT6A FGFBP1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IRAK1 NLRP3 MMP9 PLA2G7 MYD88 HEL-S-134P TLR1 PIK3CA FCER1A NFKB1 F2 S100A9 IL18 IL1R1 IFNG HBEGF IL1B CCL2 F2R CCR3 TIMP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R2 PPP4R4 PARP4 HEL-S-69 ASPHD1 TCP1 KCTD13 ZG16 INO80E MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 MAP2K3 MAPK3 MAP2K6 TBX6 CCDC6 PPP2R1A PAXIP1 KMT2C NR3C1 PAGR1 SMEK1 REL PPP2CA EZR SPN PRRT2 PPP4R3B TRAF2 TRAF6 NFKB1 CASP8 BPTF HEL-S-87p PCNA CCT7 TAOK2 PPARG MLL2 HEL70 PPP2R5D PTEN UNC13B UNC13A HEL-S-90n CCT6B HDAC3 SIAH1 DOC2A FAM57B FIMP CDIPT PPP4R1 CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-29 HEL-S-20 NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B YES1 NFE2L2 MAPK8 INSR NQO1 CEBPB EPHB2 SRC PIK3CA SLC7A11 HMOX1 PRKCA RBX1 PGAM5 FYN MAF GCLM AIMP2 KEAP1 GCLC CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways CAMK2A ADCY3 CDKN2A ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CAMK2G PDGFRA HGF SOS2 MET TGFA BCL2L11 EGF RPS6KB2 TPM3 FGFR2 NR1C2 PIK3R3 SUFU HIF1A PTCH2 KIF7 STAT5B IL2RG CXCL12 CALML6 ARAF CALML3 FZD10 STAT4 CALML4 IL12RB1 FRAT1 FRAT2 IFNGR1 IL13 EVI1 IL2 IL4 IL5 CXCL8 IL5RA KLK3 CSF2RB CRKL PIK3R2 PIK3R1 IL3 IL3RA EDNRB MGST1 FADD GSTT2 FZD1 WNT10B WNT10A NQO1 FZD3 TXNRD2 FZD2 FZD5 FZD7 FZD9 FZD8 GNA13 IKBKB HRAS APC2 PLCB4 IFNA13 IFNA14 PLCB1 IFNA16 PLCB2 IFNA17 IFNA10 PTGS2 RELA IFNA21 FGFR4 IF1AA9 NRAS BMP4 SHH WNT7B WNT7A FAS CTNNB1 IFNA8 IL7 BDKRB2 MAP2K1 MAP2K2 WNT5B GSTM2 RAF1 TNFSF6 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A RET CYCS GSK3B WNT2B PIK3CD CASP9 CASP3 CHUK APAF1 AXIN1 TRAF2 TRAF6 CRK ROCK1 ROCK2 AXIN2 WNT16 PIK3CA LRP5 ARHA LRP6 NOS2 BAD MTOR APC CDK6 JAG2 E2F3 FZD4 PPARG FGFR1 GLI3 HEY2 CBL WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 PTGER4 IFNA1 GRB2 PTGER2 SOS1 GSTT2B FGFR3 CCND2 TFG EML4 NKX3-1 PLEKHG5 IL15RA ARHGEF11 CDKN1B BBC3 SPI1 IGF2 CCND3 IL12B DDB2 IL12A IL6R CCNE2 IFNG IL23A PMAIP1 GADD45B GADD45G ARHGEF12 PTGER1 PTGER3 GNAI1 BAX PTCH1 SMO SMAD2 SMAD4 RXRA BCL2 NFE2L2 HDAC1 GNA11 NTRK1 ARNT2 EGLN1 EGLN3 RASGRP4 EGLN2 CDKN2B ELOC HMOX1 EDNRA F2R RALBP1 CTBP1 PLD2 SKP2 ARHGEF1 RALB APPL1 CREBBP HDAC2 EP300 CEBPA CTBP2 FLT3 ZBTB16 RARA RUNX1T1 PRKACG RPS6KB1 CCNA2 RB1 JAK3 CCND1 IL2RA IL2RB IL15 MSH6 MSH2 MAX RASGRP3 TPR VHL GADD45A F2RL3 MDM2 MGST3 MGST2 GSTM3 PTEN BRCA2 GSTM5 MMP2 RAC1 MMP3 JAK1 TGFBR2 NCOA1 RALA EGFR FLT3LG BAK1 STAT1 PML DCC MSH3 VEGFA RAD51 HEL-S-125m BCL2L1 GSTA5 GSTA4 KPG_010 RUNX1 GSTA3 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 F2 GNGT2 NFKB2 KIT VEGFB VEGFC HHIP VEGFD POLK KITLG HEL-S-22 CSF3R EPO IFNAR2 BIRC2 COL4A2 BIRC3 COL4A1 COL4A4 COL4A6 IFNAR1 CSF1R TXNRD3 IL7R HSP90AB1 FLT4 LAMC2 ITGAV CDKN1A ITGA6 LAMA1 LAMA4 LAMA3 ITGB1 LAMB3 LAMB2 STAT2 EPOR ALK ERBB2 NFKBIA CTNNA1 CTNNA3 CTNNA2 CXCR4 RPS6KA5 ITGA2B RAC3 E2F2 IFNA6 IFNGR2 LAMC1 FH CKS1B ITGA2 TRAF1 TRAF4 COL4A3 TRAF5 RARB COL4A5 BIRC7 MAPK10 RXRB RXRG LAMA5 MAPK9 MAPK8 LAMB4 TGFB1 STAT3 CCDC42 GNAI3 JUP CASP8 BDKRB1 LAMB1 KNG1 CCNE1 EDN1 BIRC5 CSF2RA TRAF3 PDGFA GSTM1 BRAF IGF1 TGFBR1 FOXO1 IGF1R RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 NR3A2 AGTR1 IL6ST NOTCH2 NOTCH3 CCDC6 NOTCH1 LEF1 PRKCB HES1 HES5 PRKCA TCF7L2 TERT TCF7L1 ADCY9 GSTM4 BMP2 KEAP1 LPAR1 PLCG2 PLCG1 IKBKG JUN SKP1 PAX8 GNG12 GNG11 NFKB1 GNG13 RBX1 IL6 SP1 GNB2 GNB1 IFNA2 GNAS GNB4 BCR GNB3 GNB5 PIM1 PIM2 GNGT1 HEL-S-21 FOS IL13RA1 PLCB3 DAPK2 CAMK2D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 LEP LPIN1 MAPK8 PPARG INSR NR3C1 CEBPA CEBPB FOXO1 CEBPD IL6 IRS1 RXRA CREB1 TWIST1 PPARGC1A TNF PCK2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 CREB3L3 CREB3L4 RELA RELB IL10 CREB3L2 NFKB1 CREB3 NFKB2 IL6 CREB1 IL1B MAPK12 REL CREB5 MAPK13 CCL2 MAPK11 MAPK14 CD14 ATF4 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CDC45 MRE11A PML FOXM1 SMARCAL1 RAD50 RAD51 CDK2 DCLRE1A RPA1 UBE2D3 HUS1 FANCD2 HERC2 TOPBP1 CLK2 RECQL EEF1E1 CLSPN TDP1 H2AX SMARCC2 FEN1 NBN SMC1A RNF8 CEP164 ATRIP SHFM1 CDC2 RAD52 CHEK2 RAD17 RAD1 CHEK1 RAD9A XPA PPM1D RBBP8 BCL6 MDC1 IKBKG TRIM28 MSH2 BRIP1 TP53BP1 MCPH1 RECQL4 WRN SP1 FANCA BARD1 UIMC1 PALB2 RFWD3 PLK1 PCNA PRKDC MCM2 PARP1 ABRAXAS1 BRCC3 MDM2 ATM ATR BRCA1 POLN BRCA2 RMI1 USP1 TOP3A XRCC5 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 ACADS ACSL3 SLC22A5 ACADM HADHB PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 SRD5A2 CYP21A2 AKR1D1 AKR1C1 HSD3B1 CYP17A1 HSD3B2 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma CDKN2A EZH2 KIF23 KDR PDGFRA HGF CTBP2 PRKAA2 MET RPTOR CCL4 TGFA DEPTOR PRKAG1 MLST8 PDGFC PRKAG2 FLT3 EIF4B EGF WIF1 RPS6KB2 PRKAG3 FGFR2 RPS6 PRKAB2 RPS6KB1 RHEB PRKAB1 AKT1S1 HIF1A LIMD1 MCL1 CCND1 TNNT1 ITGA4 NF2 TSC2 TSC1 CXCL12 YAP1 FABP4 FZD10 ROR2 FRAT1 FRAT2 IL10 CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E MAX DKK1 DKK2 DKK4 SFRP4 DDIT3 BARD1 CSNK2B STK38L TNIK ULK2 ULK1 FOSL1 FZD1 CDK7 WNT10B WNT10A FZD3 MDM2 ATM FZD2 FZD5 FZD7 FZD9 UHRF1 FZD8 PTEN BRCA1 LATS1 TEAD4 MMP2 LATS2 MMP3 JAK1 HRAS TEAD2 TEAD3 MMP14 PLCB4 EGFR NTF4 FLT3LG PAK1 BAK1 STAT1 FGFR4 MAP3K1 VEGFA CSNK1A1 WNT7B SFRP1 SLC7A5 WNT7A CTNNB1 FGF10 HMGB1 RPS6KA3 CSF1 HBEGF MAP2K3 MAP2K4 CHD8 MAP2K6 MAP3K5 MAP2K1 MAPK14 MAP2K2 MAP3K10 WNT5B MAP3K11 RAF1 KMT2C EPHA2 AGER ASXL1 WDR5 BAP1 DVL1 FGF8A DVL2 DVL3 KIT WNT1 WNT3 WNT4 RBBP4 FGF6B WNT3A VEGFB MAPKAPK2 CYCS VEGFC MCU VEGFD GSK3B WNT2B PIK3CD WWC1 MAP2K5 NGFR SOX17 KITLG RB1CC1 CER1 CSF3 AXIN1 TRAF2 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA MAPK7 CSF1R NTRK2 LRP5 EFNA5 EFNA4 LRP6 FGF20 FGF22 FGF7 FGF21 CXCL5 FGF8 EFNA1 MTOR FGF9 APC EFNA3 FGF14 CSNK1A1L EFNA2 FGF13 FGF18 FGF12 FGFR1 ITGB4 FLT4 LAMC2 AMOT FGF2 FGF7B ITGAV FGF7A RASSF7 CDKN1A NGF ITGA6 FGF5C LAMA1 LAMA4 LAMA3 GRB2 CXCL1 AREG SOS1 FGFR3 NLRP3 ANGPT4 IDO1 MMP9 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 LAMB2 MEF2D BDNF SRC SHC1 SETD2 CCL5 EIF4EBP1 CCL2 MOB1A CTNNA1 CTNNA3 CTNNA2 RASSF2 RASSF3 RASSF4 BBC3 RASSF6 ITGB3 RPS6KA5 HCFC1 IGF2 PHC1 CCND3 PRSS23 IL34 MAD2L1 MAP3K6 DSC3 LAMC1 BAG2 MDK RNF2 CTHRC1 MOBKL1A ITGA1 PAK6 CDH9 CDH8 PAK4 CDH4 ITGA2 CDH10 COL4A3 CDH11 CDH12 HEL-S-31 CDH15 AJUBA COL4A5 CDH17 VGLL4 ACTA2 CIT CD44 MAPK10 CDH19 MAP4K1 CDH24 LAMA5 MAPK9 WWTR1 MAP4K2 MAPK8 SPARC MINK1 TGFB1 LIN28B BAX MAP4K3 CTGF MAP3K2 EED LAMB1 SELE TTI1 MDM4 LGALS9 SUZ12 HMGN1 CCNE1 PPARGC1A CSF2 BMI1 FGF23 FLT1 PRB1 INSR PRB2 CDH6 PDGFA CDH2 IGF1 CD47 OGT FOXM1 CDH16 FOXO1 IGF1R INS RASSF1 CDK4 MYC AKT3 CDK2 YY1 MAPK1 RYK MAPK3 ROR1 ATF2 PDGFD BCL2 ACTG1 EIF4G1 PRKAA1 SOST LEF1 NTRK1 TCF7L2 TERT NTF3 TCF7L1 PIGF KREMEN1 SENP2 SFRP5 ATF3 CXXC4 PORCN NOTUM SLC3A2 BTRC JUN NFKB1 IL6 SP1 SETD5 CTBP1 PS1TP5BP1 HEL-S-1 RPS6KA1 BTC GABPA SETDB1 CDH18 MAD1L1 ACTA1 CREB1 IL1B ACTG2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling TLR4 IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 TRAF3 LY96 IFNA21 IF1AA9 TIRAP MAP3K7IP1 IFNA8 AKT3 MAP2K3 CCL5 MAP2K4 MAPK1 TNF MAPK12 MAPK3 MAP2K6 MAPK13 CCL4 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B IFNA7 MAP3K7 RIPK1 IL12A TICAM1 IRAK1 IRAK4 MAPK10 MAPK9 TAB3 MAPK8 MYD88 CHUK LBP TRAF6 TBK1 IFNAR2 IKBKG JUN IFNAR1 NFKB1 IL6 TLR5 CXCL8 CASP8 SPP1 IFNA2 TLR9 TLR7 FADD FOS IFNB1 IKBKB IL1B RAC1 CXCL9 IFNA1 CXCL11 IRF3 TLR8 CD14 TLR3 CCL3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2 EPHX2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway KIR2DL1 KIR2DL3 VAV1 PLCG1 PRKCA LCP2 IFNG CD34 CSF2 HLA-C TNF RAC1 FYN HRAS LAT TYROBP PRKCQ GRB2 SYK PTPN6 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX H2AB1 H3C8 SUZ12 BCL6 H2AZ1 EZH2 H2AZ2 RNF2 H3C15 H2AB3 PCGF1 H3F3B MAPK1 H2AJ MAPK3 EED MACROH2A1 BCOR MACROH2A2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH COQ6 COQ2 SLC52A1 PDSS1 ETFA COQ8A FLAD1 COQ9 APTX COQ7 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMB3 LAMA5 LAMB2 SRC SHC1 IRS1 EIF4EBP1 MAPK1 ARHA MAPK3 PTPN11 MAPK14 MTOR PIK3R2 PIK3R1 LAMB1 ITGB4 LAMC2 LAMC1 PRKCA ITGA6 RAC1 LAMA1 HRAS LAMA3 GRB2 SOS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HEL-68 HCLS1 TLR4 KRT18 TUBA2 ITGB1 ARPC2 ARPC3 TUBA8 LY96 WASL ROCK1 WAS ROCK2 TUBB8 TUBA1C CTNNB1 CLDN1 TUBB6 TUBA1B TLR5 TUBA1A ARHA FYN TUBB1 ARHGEF2 CDC42 TUBB ACTG1 TUBA4A YWHAQ TUBB2A PS1TP5BP1 NCL NCK2 TUBAL3 NCK1 YWHAZ PRKCA TUBA3E ARPC5 ARPC1B TUBB4B EZR CD14 TUBB4A ARPC4 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 MTARC2 MOCS1 XDH GPHN AOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds GSK3B FZD1 MBOAT1 DKK3 LEF1 AXIN1 CSNK1A1 FZD7 FZD8 TCF4 CTNNB1 DVL2 SFRP4 WNT1 TNKS APC CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells RGS16 CAMK2A ADCY3 ADCY1 CACNB1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G RGS10 CASQ1 RGS11 FKBP1A GJB1 ADRA1B ADRA1A GNAZ GJB6 GNAI1 GJA9 ATP1B3 STIM2 GJC1 GJB4 GJB3 GNAI3 ANXA6 GJD2 HEL-S-99n CASQ2 ATP1A4 PLN KCNJ3 KCNB1 CXNA GNAO1 ADRB1 ATP1B2 ATP1B1 CAMK1 FXYD2 CHRM1 ATP2B3 ATP2B2 ATP2B1 HEL2 GJB2 ORAI1 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 CACNA1C RGS6 RGS7 PRKCH PRKCB GNA11 PRKCE PRKCA CACNB3 CACNA1S ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ CHRM2 CHRM3 GRK5 GRK4 ADRA1D SFN ADRB3 GNG12 GJA3 GNG11 GJA5 GNG13 GJA8 PKIB CXNO PKIA GNB2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 CACNA1B RYR1 RYR2 ATP2A2 CACNA1A ARRB2 RYR3 GNGT1 KCNJ5 YWHAQ HEL-S-1 YWHAG CHRM4 CHRM5 GJA4 YWHAZ ADRB2 PLCB3 RGS18 RGS17 CAMK2D RGS14 CAMK4 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling EGFR CREBBP AGTR2 CSF2RA F2RL2 MAPKAP1 IL10RA SRC TYK2 PDGFRA SOCS3 MAPK1 PTPRC IL11RA MAPK12 MAPK3 MAPK13 CTF1 RPTOR GHR IL15RA MAPK11 MAPK14 DEPTOR AGTR1 IL6ST MLST8 IL10RB IFNGR2 PRKCB IFNLR1 AKT1S1 IL6R OSMR JAK3 IL20RA IL20RB IL27RA IL2RA IL2RB MAPK10 MAPK9 IL2RG MAPK8 STAT3 CSF3R IFNAR2 IL21R CNTFR TRIM28 IFNGR1 IFNAR1 MAPK7 PTPRT IL5RA MPL CSF2RB MAPK15 IL22RA1 F2R MTOR IL9R IL3RA IL7R SETD7 F2RL3 DUSP2 MAPK6 MAPK4 JAK1 RICTOR DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism DDC NQO1 MAOA PRKACG PPP2CA TH HEL-S-44 TYR HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC5 CD44 CASP9 SMAD4 MAPK8 PTGS2 CASP3 TGFB1 STAT3 MYOF RRM2 VEGFA COL4A2 TGFBR1 VAV2 BIRC3 JUN NFKB1 FRZB MYC IL6 CXCL8 MAPK3 NOS2 PTPN11 MAPK14 BCL2L1 HNF1A LEF1 TNFSF6 E2F2 HEL-117 IL6R CDKN1A BRCA1 HIF1A CXCR1 RAC1 JAK1 GRB2 CCND1 SOS1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders ECHS1 ACAT1 PSAT1 PSPH ENO1 HEL-S-68p GLDC AMT HEL-S-30 PHGDH HEL-S-20 SLC2A4 ETHE1 SQOR SUOX SPCS1 CDO1 GCDH HEL-S-51e LDHB MPC1 HEL-S-133P GPT HK3 DHTKD1 G6PC1 HEL-S-32 GCK SLC25A15 ASL MOCS2 MOCS1 SFXN1 GPHN ARG1 HEL-S-162eP CBS PFKL SLC25A1 ENO2 PFKM ENO3 SLC25A5 MPC2 PGAM2 ALDH7A1 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-87p CTH MOCS3 HK2 AASS SLC7A2 HEL60 PCK1 PDHA1 MDH2 GOT2 PKLR ASS1 XDH GLUD1 ALDOB SHMT1 FBP1 PC SLC2A3 BTD HLCS SLC2A2 OTC GLS2 AADAT DLAT MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes AP3D1 ARHG ARCN1 WDR11 CEBPB PPIB LAMTOR3 PLXND1 TUSC2 ARID4B HEL-S-30 VPS39 FADS1 TNLG5A TPM3 GYS1 RAB34 MAP3K8 ANAPC1 TMED10 RAB5C ADIPOR2 SLC1A4 CORO1C SAC3D1 MCL1 MPDU1 CD164 SNAP23 BRPF3 HMGA1 CAP1 TBCA IGF2R BCL6 MENT SLC25A1 ADPGK THBS1 TNFAIP2 ADAR LMNB2 TUBA1A TMEM109 ACP2 PRSS21 SCYL1 TXN2 RFT1 DDX5 UNC93B1 GNA13 DNAJB1 POLR2C SPTLC1 ATP6V1F CDIPT ATP6V0E1 POLE4 FMNL2 SERPINE2 CTNNB1 DCAF7 PNP CHORDC1 MAPK14 GOLGA7 CDK5RAP3 BCL2 PPIF IFRD1 LPL PISD MTHFD2 TYMS RTN4 POM121 MRPL20 SLC7A11 RDH10 KCNN4 SNX6 PHC2 SFXN1 HEL-S-26 HEL-S-47e ARF4 TRAM1 HMOX1 MRC2 TMEM43 TMED3 SH3BGRL3 CTSC CDK6 ANXA2 ATP2A2 PRPF40A YWHAQ SLC7A6 CDCP1 FRG1 PTRH1 NELFCD HEL-S-66 PTPA USP1 CA12 SHOC2 SRSF10 APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis BIRC5 IRF7 CDKN2A BAK1 RELA TRAF3 CASP10 MAP3K1 IGF1 IGF1R FAS LTA MYC MAP2K4 TNF NFKBIA IRF6 BCL2L11 TP63 NFKBIB BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO IGF2 TNFSF6 CASP6 IRF4 RIPK1 IRF1 PMAIP1 TRAF1 TNFRSF10B MCL1 CYCS MAPK10 BNIP3L CASP9 CASP3 TP73 CHUK APAF1 BAX TRAF2 HRK IKBKG BIRC2 PRF1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 TNFRSF25 CASP8 CRADD BAD SCAF11 PIK3R1 BCL2L2 IRF2 FADD HELLS MDM2 TNFRSF21 TRADD IKBKB TNFRSF1B IRF3 NFKBIE OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F8 CYP2C8 CYP2J2 CYP4F11 CYP46A1 CYP26A1 CYP2S1 CYP27C1 CYB5R3 CYP7B1 CYP26B1 CYP4V2 CYP27B1 CYP2C19 CYP3A7 CYP3A4 CYP2W1 CYP11B2 CYP27A1 CYP2R1 CYP3A43 CYP2A7 CYP8B1 CYP26C1 CYP2C9 CYP2A6 CYP2B6 CYP17A1 CYP2A13 CYP4A22 CYP2F1 CYP4B1 CYP20A1 CYP4F2 CYP4A11 CYP4F12 POR CYP51A1 CYP24A1 CYP7A1 CYB5R1 CYP11A1 CYB5R4 CYB5B CYP1A2 CYP1B1 CYP1A1 CYP4Z1 CYP2E1 CYP2U1 CYP4F22 CYP4X1 CYP2C18 CYP4F3 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CREBBP EP300 FGFR4 CEBPA SETD2 MYC ERBB2 KDM6B ARID4B MYB MAP2K2 NCOR1 NFIB ARID5B NOTCH1 RAF1 KMT2C TLK1 SMC1A MYBL1 CHEK2 CHEK1 PIK3CA BCORL1 MAX FGF16 PRKDC FBXW7 MAML3 SRCAP JMJD1C CTBP1 HIST1H1E ARID1A CMTR2 MAGI1 DTX4 FOXO3A HIST1H2AK INSRR FOXP2 MORF4L1 ATM KAT6A MYCBP MGA KANSL1 UHRF1 PTEN BRCA1 HRAS BCOR SMARCE1 ERBIN MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MYLK PLCB2 RCAN1 CISH MYEF2 IGF1 MAP3K7IP1 IGF1R LIF CTNNB1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 GATA4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 CTF1 MAP2K1 MAPK14 NFATC4 MAP2K2 CDK9 IL6ST EGF RAF1 IKBKE FGFR2 PRKCB DVL1 PIK3R3 WNT3A EIF2B5 GSK3B PIK3CD NPPB MAP2K5 MAPK8 TGFB1 CHUK STAT3 IKBKG ROCK1 ROCK2 PIK3CA MAPK7 NFKB1 LRP5 LRP6 ARHA MAP3K14 MTOR PIK3R2 PIK3R1 CALM1 FZD1 CDK7 FZD2 FGF2 NPPA EDN1 IKBKB PPP3CA MAPK4 RAC1 CAMK2D MYLK3 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 SLC19A3 DKFZp667O1614 HEL107 SLC19A2 OGDH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IFI6 STAT2 STAT1 IFNGR1 ISG15 SOCS3 SOCS1 HLA-B MHC2TA NOS2 IFNA2 PTPN11 TAP1 CYBB IRF2 OAS1 SPI1 IRF9 IFIT2 H4C9 IFNGR2 IRF4 EIF2AK2 IRF8 IRF1 GBP1 IFNB1 IFNG IL1B JAK1 CXCL9 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 ITGB1 CDKN2A EGFR HEL113 IGF2R STAT1 BAX IGF1 CLDN7 JUN IGF1R SRC NFKB1 CTNNB1 CLDN1 CDK4 CDK2 TLN1 PIK3R1 NOTCH1 BCL2 CDKN1B PSEN2 ABCC1 IGF2 CCNE1 MDK PRKCA PECAM1 PTEN TACSTD2 RB1 ACVRL1 RAC1 PAK4 CCND1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 LPAR1 JAG2 ALPL PLAT CALU SOX6 VEGFA GJA5 DLL3 DLL4 ITGA1 MGP FGFR3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT1 ACAT2 HMGCR GGPS1 IDI1 FDPS MVK HMGCS1 FDFT1 IDI2 PMVK MVD HMGCL FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP STAT1 SNAI1 BMP4 ATG5 MAPK1 MAPK12 IHH MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 FGF9 MAP2K2 SOX9 RAF1 FGF18 PTHLH RBL1 CDKN1A NPR2 PTH1R PPP2CA BMP2 THRA FGFR3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades TFPI C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PAK1 ZAP70 GRAP2 LCP2 CDK4 CARD11 BCL10 PTPRC TNF FYN MAPK3 NFATC2 LAT MAP2K1 NFKBIA CTLA4 MAP2K2 PTPN6 RAF1 MAP3K8 MAP3K7 CD40LG IFNG PRKCQ LCK GSK3B DAG1 MAPK9 CHUK CD3D CD8A IKBKG PLCG1 IL10 JUN PIK3CA NFKB1 IL2 IL4 IL5 RRAS MAP3K14 ITK PDCD1 ICOS CALM1 CBL NCK1 FOS IKBKB CHP1 CSF2 AHSA1 GRB2 SOS1 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP SMAD9 BMP7 ZNF423 PPARGC1B PPARG DGIC ZIC1 CEBPA CEBPB BMP4 CEBPG DKFZp781O1323 SLC7A10 PRDM16 PPARGC1A HSPB7 SMAD1 CIDEA EBF3 BMP2 HOXC9 HOXC8 MPZL2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer CDKN2A EGFR BAK1 NRAS BRAF ALK RASSF1 PDPK1 CDK4 HGF AKT3 RXRA ERBB2 MAPK1 EML4 SOS2 KRAS KIF5A MET MAPK3 HEL-S-61 MAP2K1 STK4 MAP2K2 TGFA EGF RAF1 E2F2 PRKCB DDB2 PRKCA RB1 STAT5B GADD45B JAK3 GADD45G CCND1 RET CYCS RARB PIK3CD FHIT POLK RXRB CASP9 RXRG CASP3 STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA CASP8 BAD GADD45A CDK6 E2F3 CRABP2 CRABP1 FOXO3A CDKN1A HRAS GRB2 SOS1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 RPH3A MLPH UNC13D MADD TBC1D10A SYTL2 EXPH5 RAB27A RAB27B SYTL1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MCM5 MCM6 CDKN2A CCND2 CDC45 WEE1 CDK4 MYC CDK2 RPA3 RPA1 CREB3L3 CDKN1B CREB3L4 CCND3 E2F2 CCNE2 POLE TFDP1 CDKN2D RB1 CCNB1 CDKN2B POLE2 CCNG2 CDKN2C CDC2 CCND1 PRIM2 POLA2 MYT1 CCNH CDKN1C MNAT1 GADD45A PCNA TFDP2 MCM2 CDK6 E2F3 CDK7 MDM2 CCNE1 ATM PRIM1 CREB3 CDKN1A CREB1 ORC6 ORC3 ORC2 MCM7 ORC1L MCM3 ATF6B DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 HDAC2 LAG3 STAT2 EP300 STAT1 CXCL2 TRAF3 AP1G1 NUP98 RAE1 PPBP CXCL6 IFITM1 CXCL3 CCL5 TP53I3 TNF ACE2 CCL2 CCL4 TFAP2A LARP1 MX1 CD160 PF4 IFIT2 RIPK1 IL6R hEMMPRIN TRAF5 TANK TGFB1 CXCL12 TRAF2 TRAF6 TBK1 IFNAR2 DHX58 TRIM25 IL10 HAVCR2 IFNAR1 NFKB1 IL6 CXCL8 MAVS CASP8 RIGI CXCL5 TLR7 FADD TRADD IL8RB IFNB1 CSF2 JAK1 CXCL9 CXCL17 CXCL13 CXCL11 CXCL1 IRF3 CCL3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP9 CASP3 BBC3 APAF1 TP53AIP1 BAX MDM2 ATM EI24 SHISA5 CYS1 ZMAT3 PERP DDB2 PTEN PMAIP1 SIAH1 CASP8 TNFRSF10B SESN3 CHEK2 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP LRP5 LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ECHS1 TDO2 IDO1 ACAT1 STAT1 ASMT TPH2 TPH1 AOC1 ALDH8A1 IL4I1 DLD DDC MAOA AOX1 ALDH2 GOT2 GCDH CYP1A1 KYAT3 KYAT1 AANAT INMT AADAT HAAO AHR KMO KYNU AFMID IDO2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 MAPK8 PTGS2 TSC1 PINK1 IKBKG FOXO1 PIK3CA HMOX1 NFKB1 GSX1 IPCEF1 IL6 PIP CXCL8 MAP2K3 CDK2 MAP2K4 TNF NOS2 MAP3K5 ATF2 MAPK14 MTOR BCL2L1 BCL2 NFE2L2 NQO1 RPS6KA5 SIRT1 MDM2 CCNE1 RHEB ATR NRF1 FOS CDKN1A PTEN IKBKB CREB1 KEAP1 IL1A UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP9 CAMK2A EGFR SMAD2 CREBBP EP300 RELA CTNNB1 HDAC5 TRPC4 CDK2 MAPK1 TNF MAPK3 PTPN11 MAPK14 AGTR1 CYBB BCL2 NCF1 NCF4 ABCA1 AIFM2 CYBA COL2A1 CDC2 VCAM1 GSK3B ACTA2 NPPB COL1A1 CASP9 MAPK9 COL3A1 MAPK8 CASP3 TGFB1 CHUK ALOX5 STAT3 BAX ESPL1 HMOX1 NFKB1 PLN IL6 UTS2R DDIT3 ARHA PCNA NCF2 UTS2 CCNE1 NPPA GSK3A NOX4 PTEN IKBKB MMP2 IL1B HSPA2 IRF3 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL5 ACSL3 STAR FABP4 LPA DBI SLC27A2 SORT1 APOC2 SLC27A3 SOAT1 APOC1 LIPA PCSK9 APOA4 SCARB1 APOB LDLR MYLIP FABP1 APOE SLC27A1 ABCA1 SOAT2 SLC27A4 ACSL1 STARD3 FABP2 ACSL6 NPC2 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis BMP7 TCF21 SIX2 WNT9B RSPO3 FOXD1 OSR1 ALDH1A2 GREB1L PAX2 MEIS1 FGF20 WNT4 WNT3A RSPO1 FGF8 NOTCH2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 CCL13 IL10RA ACKR3 CCL8 CCL7 CCL4 CCL1 CCL18 TNFRSF14 CCL15 TNLG5A LEPR ACVRL1 CCR10 CCR1 XCR1 IL2RA IL2RB IF2B1 IL23R IL15 GDF11 TNFRSF10A CD27 IL2RG IL-21 CXCL12 IL18RAP IL21R IL12RB1 IL10 CCR8 IFNGR1 EDAR CCR4 IL13 BMP8B IL2 IL4 IL5 CXCL8 IL5RA CSF2RB CCR3 IL3 IL3RA GH1 IL9 BMPR1A BMPR2 TNLG7C TNFRSF19 LTB IL1RN CXCL17 CXCL13 IF2D TGFBR2 CXCL14 IF2G IL36A CCR6 IL1A IL36B INHBA GDF5 IL36RN IL36G PPBP INHBB IFNW1 BMP4 IL1F10 CXCL6 IL24 FAS IF1IB1 IL27 CX3CR1 CXCL3 IL7 PF4V1 CSF1 IL19 XCL2 TNF IFNK XCL1 IFNL2 IFNL3 CCL20 ACKR4 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 TNFSF6 TWEAK TNFRSF12A IL1R1 ACVR2A IL27RA NGFR CSF3 CSF3R EPO IFNAR2 CNTFR TNFRSF1A IFNAR1 BMP3 CSF1R GDF10 CXCL5 GDF3 TPO IL7R NODAL TNFRSF21 IFNB1 NGF IL1R2 CXCL9 CXCL1 ACVR1B CCL3 TACI PRL CNTF EPOR CXCL2 CCR2 PRLR CCL23 CCL11 LIF LTA CX3CL1 CCL19 CCL5 CCL28 CCL2 IL15RA GHB2 IL18R1 GHR AMH CXCR4 CD40 IL25 CXCR6 IL34 IL10RB IFNGR2 IFNLR1 BMP10 TNLG7A IL6R CD40LG IFNG IL23A IL17F IL17D IL17C TNFRSF10B IL17B IL20RA IL20RB IL17A TGFB1 TNFRSF4 TNFRSF9 MPL ACVR1 IL22RA1 IL9R ACVR2B TNFSF11 GDF15 TNFRSF11A IL1RL2 TNLG2B CSF2 CXCL11 CSF2RA IL17RC IL17RB BMP6 IL17RA TGFBR1 IL11 IL11RA gdf7 TNFSF14 GDF1 GDF6 RELT IL6ST CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 BMP7 INHBC BMP5 TNFSF10 INHBE TNFRSF18 ACVR1C LTBR TNFRSF11B AMHR2 CCR7 IL1RL1 CXCR5 GDF8 LEP ANP32B BMP15 TNLG1B IL6 TNFRSF25 CCR5 IFNA2 TNFRSF13C TNFRSF10C TSLP CXCL16 CCL4L2 IL13RA1 IL8RB GDF9 IL18 TNFRSF1B CXCR1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNAI1 GNG2 KCNK9 CHRNA5 TH CHRNA6 KCNK3 PPP1R1B SLC18A2 DDC DRD2 DRD3 CHRNB2 CHRNA3 DRD4 GNB1 CDK5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA4 ITGB1 HLA-DMA CD63 CD151 SHH HBEGF LGALS3BP HLA-DRA CHST6 EXT1 CRY2 ALKBH3 HLA-DMB CHST1 LEF1 GLI3 CD82 MAPK8IP1 IGSF8 NRXN1 CD19 SPPL2C B4GALT4 PRDM11 ACCS PHF21A C11orf96 ALX4 TP53I11 LARGE2 EXT2 PEX16 IZUMO1 ITGA6 SDCBP SLC35C1 SYT13 VANGL1 MS4A1 FREY1 REST SLC25A17 B4GAT1 TIMP1 B3GNT7 PEX3 TSPAN18 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 TGFB1 CCR2 IL12RB1 IFNGR1 IFNGR2 IL12B CCR7 CCR4 IL12A IL2 IL4 IL5 CD40LG IFNG CCR5 CSF2 CXCR3 CCL4 IL18R1 CCR3 CCR1 CCL3 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA2 PDHA1 CHKA ACHE PEMT ChAT MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 SOCS3 MYC STAT3 CHI3L1 BAX IL6ST AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG2 CSN1S1 EIF4E EIF4G1 TSC2 EEF2 PRKAG3 PRKAA1 CSN3 EEF2K PRKAB2 RPS6KB1 PRKAB1 CSN2 PRKAA2 RPTOR MTOR EIF4A2 PRKAG1 MLST8 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 NFKB2 APOE RELA SPI1 TRAF6 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway EDN2 TSC22D3 PTGS2 SNAI2 POU5F1 B3GNT5 CDC42EP3 ACKR3 TNFAIP3 PMP2 ANGPTL4 MFGE8 IL11 RXRA NR1I3 FGD4 GPR153 CCL2 SERTAD2 CCL20 CAVIN2 PTGES3 NR1i2 KTN1 RGS2 NR3C1 DNER SCNN1A NFKB2 SLC26A2 ABHD2 DNAJC15 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 PPP1R14C ALOX5AP NAV3 ADGRF4 BIRC2 CDKN1C BIRC3 JUN PRRG4 STOM S100P SPRY1 THBD TNS4 PDE4B BHLHB2 SLC19A2 PLK2 AMIGO2 CPEB4 EPB41L4B ENC1 ANKRD1 FGFBP1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NDUFB10 MEF2D RELA VAV1 SH2B3 ZAP70 GRAP2 TNFAIP3 PDPK1 LCP2 CARD11 BCL10 SOCS1 LAT NFKBIA PTPN6 CDKN1B CUL5 MAP3K8 DGKZ SH2D1A REL PRKCQ LCK RASA2 DGKA TMEM222 MAP4K1 ARIH2 CD3G UBASH3A CD3E CHUK RPRD1B CD3D FIBP CD8A CD5 TRAF6 AGO1 IKBKG PLCG1 NFKB1 ARHH MAP3K14 ITK PIK3R2 PIK3R1 RNF7 GNA13 IKBKB GRB2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling IBSP PDGFRA COL1A1 TNFSF11 ITGB3 BGLAP PTH1R PTH TNFRSF11B SLC17A2 ITGAV FGF23 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 HEXB SCARB2 HEXA GM2A PSAP NEU1 NPC1 GLB1 NEU3 NEU4 GLA LIPA NPC2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits SRC NOTCH1 TCF7L2 TCF7L1 CXCR4 TNC LEF1 POSTN VHL VEGFA VCAM1 CYTIP GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GSTM2 GSTT2 GPX2 GSTA5 GSTM1 GPX3 OPLAH HEL-S-26 HEL-S-64p GPX1 GPX4 GCLM HEL-75 GCLC STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 INSIG1 NR1H2 INS DBI YY1 PRKAA2 PRKAG1 PRKAG2 SCARB1 CAMP ACACA LDLR FASN PRKAG3 PPARGC1B PRKAA1 LPL SIRT1 PRKAB2 IDI1 FDPS NFYA PRKAB1 SREBF2 HMGCS1 MVD SAR1B HEL-S-32 CDK8 CYP51A1 MBTPS1 HMGCR ACLY PIK3CA SAR1A RNF139 SEC23B FDFT1 SEC31B SEC31A AMFR SP1 SEC24C MBTPS2 SQLE MED15 FGF21 SCD MTOR ACSS1 PPARG GPAM RBP4 SEC23A GSK3A CREB1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 IRAK4 IRF7 STAT2 MYD88 STAT1 TRAF3 TRAF6 TBK1 IFNAR2 TMPRSS2 TYK2 IFNAR1 MAVS TREML4 RIGI ACE2 TLR9 TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 JAK1 IFIH1 IRF3 TLR3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GLS RPS6KA2 ARAF BRAF PFKFB2 DLD RPS6KA3 MAPK1 HEL-S-30 MAPK3 CPT1A RPTOR MAP2K1 MTOR MAP2K2 HEL-75 MLST8 ACSS1 PDHA1 RAF1 NAMPT PKLR SLC16A3 RPS6KA1 LDHB HEL-S-304 HEL-S-133P DLAT PPARGC1A GPX4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview PLA2G1B MMP9 BMX ANGPT1 PAK1 VEGFA GRB7 SRC KDR SHC1 PLXND1 PDPK1 MAP2K4 MAPK1 KRAS MAP2K6 ATF2 PTPN11 MAPK11 MAP2K1 MAPK14 RAF1 SLIT2 GRB14 MAP3K7 PXN F2 PRKCA ROBO4 PTK2B PIK3CD DAG1 MAPK8 CRK WAS PLCG1 NRP1 SHB TIMP4 BAD VHL MTOR APC CDC42 SEMA3A IQGAP1 FGFR1 ROBO1 NCK1 NOX4 MMP2 FRS2 RAC1 GRB2 SOS1 MMP14 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 CDH2 AK4 PTK2B CCR8 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 UGT1A10 CYP1A2 HSD17B3 CYP1B1 HSD17B7 SULT1E1 HSD17B2 CYP2C19 CYP3A7 UGT2A2 CYP3A4 HSD17B10 HSD17B4 HSD17B1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 MAD1L1 PTTG1 STAG1 CENPE CDC20 BUB1B SMC3 APC ESPL1 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GPR64 PTH2R CALCR ADGRL4 CRHR1 GLP1R ADGRL2 ADGRL3 ADGRE2 GHRHR PTH1R ADGRE5 ADCYAP1R1 ADGRL1 VIPR2 CRHR2 GIPR CALCRL GCGR SCTR TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways BCAT2 PSAT1 BAAT DHFR PSPH AMT CHDH GPX1 PHGDH HEL-S-44 HEL-75 GCLC pcap GAD2 CDO1 MTR HEL-S-75p GAD1 HEL-S-51e MTHFD2 TYMS DNMT3L GPX6 MAT1A HEL-S-64p GPX4 HEL-S-61p GPX2 CBS BCAT1 ALDH7A1 DNMT3B CTH GCLM AGXT2 PCYT1B CHKB AHCYL1 PCYT2 SLC25A48 CHKA BHMT2 ETNK1 AHCYL2 GPX7 PEMT MTHFD1 MTHFD2L CHPT1 GPX3 SHMT1 MTHFD1L CEPT1 HEL-S-182mP 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NLRP3 GDF5 ChAT DKFZp781O1323 JUND ATF2 BCL2 CUL5 SMARCC2 SIRT1 EIF4ENIF1 ELOA BMP2 SF3B1 MYBBP1A MAPK8 ERCC5 RIF1 SIRT6 NEO1 HSF1 MYO1C MEN1 DLD SMAD1 PCNA SMAD9 DDX21 OGDHL FAM170B CEFIP BMPR1A VSTM4 RGMB BAZ1B NOG WDFY4 PARG LRRC18 SLC18A3 ARHGAP22 HSF4 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 ITCH UVSSA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway ARL4A WDCP MIXL1 C9orf72 KLF4 KLF5 GATA3 RGS10 SETD2 HAND1 CTBP2 RPL38 LEFTY1 AMH LEFTY2 ZIC5 TBX6 NR2A1 HES7 SESN1 GATA6 TCF4 C1QBP TBX1 FOXH1 TBX3 CCND1 RARB PLCH1 YAP1 CRTC1 PIAS1 TRIM28 NABP2 DKK1 ACVR1 SMAD1 DNMT3B ACVR2B SCHIP1 SMAD6 BHLHB2 FZD5 BMPR1A FZD8 BMPR2 LATS1 TEAD2 SMAD2 SMAD4 INHBA SLC2A12 HTT TET1 FOXC2 FOXC1 SNAI1 BMP4 POU5F1 CUL4B PITX2 PAX6 MEIS1 SOX2 FOXA1 ARID5B CCDC6 ACACA BMP7 NFE2L2 FOXA2 LEF1 TCF7L1 HMGA2 ACVR2A WNT3 PRKAR1A WNT3A PPP2CA ZIC2 SOX21 SOX17 CEP250 WDHD1 AXIN1 EMSY AXIN2 WDFY2 HPRT1 BCORL1 TOX CSRP2 NLK MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 FGF8 GDF3 ZFHX4 TRERF1 PBX1 EXT1 FZD4 NODAL FGFR1 TRIM71 PHF6 ZIC3 TRIM5 JARID2 VAV3 NOG PARP8 NR1B3 TOX3 AEBP2 EXT2 AHDC1 ZNF462 ADAM19 ELP4 TWSG1 MSGN1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TAF13 TBP H4C9 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD4 RAD51 RAD54B BRCA2 MRE11A POLD2 ATM RAD52 RPA1 NBN POLD3 RAD50 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IF1IB1 TYK2 STAT2 STAT1 IRF9 JAK1 IFNL2 IFNL3 IL10RB IFNLR1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND2 ND5 ND4 TIMMDC1 ND6 NDUFB10 TMEM186 C3orf60 TMEM126B DMAC1 NDUFB11 DMAC2 COA1 NDUFAF6 NDUFAF4 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ACAD9 NDUFB9 NDUFB8 NDUFAF1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 ECSIT NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFA13 NUBPL NDUFAF2 NDUFS3 NDUFA12 NDUFA10 ND1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TSC2 TSC1 ARAF MAPKAP1 NRAS BRAF PIK3CA AKT3 IRS1 EIF4EBP1 MAPK1 KRAS SOS2 MAPK3 RPTOR MAP2K1 MTOR DEPTOR MAP2K2 PIK3R1 MLST8 PARP2 PARP1 RAF1 RPS6KB1 AKT1S1 INPP4B PTEN RICTOR HRAS GRB2 SOS1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R5 PIK3CD PIK3R3 PIK3C2G PIK3C2A PIK3C2B PIK3R4 PIK3R2 PIK3R1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A IL1R1 TGFB1I1 IL1B MAOA ITGB3 TPH2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum XAB2 POLK XPA GPS1 XPC CUL4A POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 SLX4IP GTF2H5 CUL4B SLX4 ERCC2 MNAT1 RBX1 CHD1L RPA3 RPA1 ERCC1 PCNA CETN2 PARP1 CDK7 HMGN1 H4C9 POLD3 H2AC6 RFC1 POLD4 HIST1H4L DDB2 POLE RAD18 BRCA1 H3F3B LIG1 POLE2 POLD2 POLE3 UVSSA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B SMAD2 SMAD4 C1QTNF12 VEGFA COMMD1 PANK4 INTS11 ISG15 INTS13 INTS14 INTS10 GDE1 TMEM52 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK SSU72 TNFRSF14 PEX2 ATAD3C GLTPD1 ACAP3 ELAVL1 RER1 CD160 SCNN1D PEX5 MXRA8 TNFRSF18 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 PEX12 MEPCE PUSL1 TAS1R3 NADK HES4 MRPL20 OR4F5 DVL1 HES5 OR4F3 CDK11A CFAP74 MIB2 PEX10 RNF223 LRP4 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 TRAF5 INTS9 SLC35E2B C1orf159 PLCH2 PRKCZ TGFB1 CALML6 GRIK2 DKK3 ARF6 TRAF2 TRIM25 TNFRSF4 PARD6B PHKG2 RBX1 VTN GNB1 AGRN MCM2 HEL-S-72p IFIT1 ATAD3A UBE2J2 SKI TNLG2B B3GALT6 INTS4 IFIH1 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 OMA1 LONP2 TSC2 SESN2 TSC1 GDF15 LONP1 FOXO1 SLC7A7 EIF2A CLPP MYC IRS1 PHB2 MTOR HSPD1 ATF4 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map TOMM70 SLC6A19 AQR UPF2 IGHMBP2 GDAP2 NLRP12 UBB MACROD1 HEL97 MACROD2 CMTR1 MAP3K7IP1 NRP1 ISG15 PAIP1 PARP14 UBC PALS1 MACROH2A1 ACE2 MACROH2A2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling ITGB1 PIK3CD MAPK10 EGFR COL1A1 MAPK9 MAPK8 NRAS SRC AKT3 TLN1 MAPK1 MAPK12 KRAS MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RAF1 PXN ITGA1 HRAS GRB2 AREG SOS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ERN1 SLC2A4 CD36 PRKCZ PRKAG3 MAPK8 INSR PDX1 RPS6KB1 EIF2AK2 TNFRSF1A INS IRS1 TNF TRAF1 MAFA PPP2CA ACSL1 PIK3R1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 IL1B RELA TRAF3 PYCARD NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CCND2 KLF4 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 WNT5B ELAVL1 WIF1 SOST LEF1 CCND3 NKD1 NKD2 DVL1 DVL2 TCF7L2 DVL3 TCF7L1 SOX7 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 MTDH FRAT1 FRAT2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CTBP1 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response ERN1 BCL2 NFE2L2 MBTPS1 BBC3 XBP1 RTCB HEL-S-89n CASP2 MBTPS2 IL1B PMAIP1 DDIT3 TXNIP TNFRSF10B EIF2S1 PPP1R15A BCL2L11 ATF4 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair PRKDC NASP MDC1 ATM H1-1 RNF168 H4C9 NBN HIST1H4L RAD51 TP53BP1 SETD2 RNF8 SUPT16H XRCC5 SSRP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 FADD CASP9 CASP3 BAX TRAF2 BIRC3 RIPK3 TNFRSF1A RIPK1 TRADD TNF CASP8 CYCS MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 CASP9 CHKA CASP3 PEMT ASMT CHPT1 GRIN1 EHMT1 ALDH7A1 CHDH DNMT3B HEL-S-61p CYCS 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome ATP2A1 RABEP2 SH2B1 INSR TRAF2 SLN NFATC2IP VAV2 TUFM ATXN2L SPNS1 KDR IFITM1 PLN IL4 SDCCAG8 MPL NFATC2 LAT RAB5A CD81 CD82 CD19 PRMT1 HEL-S-62p CR2 RAB4A TRAF1 GRB2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMPR2 NOG SMAD6 TOB2 SMAD4 RUNX2 SMURF1 SMAD1 BMP2 TOB1 BMPR1A RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling MAPK9 PAPSS2 MAPK8 RELA CHUK STAT1 TRAF3 FHL2 RELB TRAF2 GAB2 TRAF6 PLCG1 IKBKG MAP3K7IP1 JUN SRC NFATC1 NFKB1 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 MTOR NFKBIA LYN PIK3R2 SYK PIK3R1 CDC42 TNFSF11 SPI1 TNFRSF11B CBL TNFRSF11A MAP3K7 FOS NFKB2 SQSTM1 IKBKB RAC1 TRAF1 TRAF5 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NFE2L2 MAPK8 NQO1 CEBPB EPHB2 PIK3CA SLC7A11 HMOX1 PRKCA MAF GCLM AIMP2 KEAP1 GCLC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11B PMP22 FIG4 MPZ MFN2 KIF1B RABAC1 MTMR2 EGR2 RAB7A LRSAM1 RAB4B HSPB8 LITAF GDAP1 SH3TC2 FGD4 RAB25 HEL-S-102 RAB4A RAB11A NEFL SBF2 RAB3B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR AHCYL2 MTHFD1 SHMT1 HEL-S-51e MTHFD1L TYMS MTHFD2 DHFR MAT1A AMT TCN2 HEL-S-70p CHDH MTFMT GLRX DNMT3B MTHFS FOLH1 HEL-S-61p FTCD NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK1 FLNA MAPK3 PTK2B RPGRIP1L INVS NPHP1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DOLPP1 MGAT4B STT3A STT3B ALG1 FUT8 B4GALT1 DPM2 MGAT1 MPDU1 B4GALT2 TUSC3 ALG6 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 RFT1 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B DPM1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions FOXO6 WWTR1 KNSTRN RAB13 FERMT3 YAP1 FOXO1 FOXP3 RAP1A ARHA STK38L FYB1 MAPK14 MOB1A PRDM1 LPL FOXO4 FOXO3A YWHAQ CD19 CCR7 LATS1 TEAD4 LATS2 RAC1 TEAD2 TEAD3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 TLR4 IRAK4 IRF7 MYD88 TICAM2 RELA CHUK TRAF3 RELB TIRAP TRAF6 TBK1 IKBKG NFKB1 TLR5 MAPK1 TLR9 TLR7 IKBKE TLR1 TICAM1 NFKB2 IKBKB REL IRF3 TLR8 TLR3 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling TLR4 TIFA IRF7 CISH TREM1 SOCS1 CCL5 RBCK1 CCL4 NFKBIA PTPN6 MLST8 IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B MAP3K7 IL12A PIK3R3 SQSTM1 MBL2 MAPK10 MAPK9 MAPK8 SFTPA2 LBP CYLD TLR5 CXCL8 CASP8 SPP1 ZMYND11 PIK3R2 SYK PIK3R1 PLK1 IRAK3 PELI1 SMAD6 FADD IKBKB RAC1 CXCL11 IRF3 CD14 TLR8 TLR3 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 FBXW5 LY96 IFNA21 TRAF3 CD180 IF1AA9 TRAFD1 TIRAP SIGIRR CUEDC2 SFTPD MAP3K7IP1 RNF31 PELI3 SARM1 TNFAIP3 IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RIPK1 IFNA7 TICAM1 NFKB2 BTK IRAK1 IRAK2 PIK3CD IRAK4 TAB3 MYD88 OTUD5 CHUK TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 IFNA2 TLR9 TLR7 TMED7 PIK3R5 RNF41 FOS IFNB1 IL1B CXCL9 IFNA1 CCL3 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response IL15 TGFB1 CSF3 CXCL2 PDGFA IL10 IL13 HLA-DRB1 IL2 IL4 IL6 IL5 IL7 CSF1 IL11 TNF HLA-DRA IL3 IL12B IFNB1 IFNG IL1B CSF2 CXCL1 IL1A PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA4 PSMA2 PSMC1 PSMB6 PSMB2 PSMB3 NEDD4 UBE2D1 PSMD9 PSMB10 HLA-A UBE2B HEL-S-276 PSMD6 PSMB8 HLA-B HEL-S-283 PSMD7 HLA-F PSME2 HLA-G HLA-C HLA-E PSMD4 PSMD5 PSMD2 UBE2D3 PSMD3 PSMD1 UBE2D2 H2AX UBB HIST1H2AB H2AZ1 PSMD10 UBA7 PSMD12 PSMD11 HEL-117 HEL-S-91n PSMD13 RPN2 UBC RPN1 IFNG PSMC6 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA NR1i1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways MEF2C CREBBP EP300 CTCF ASCL1 CAV3 CEBPB SCN3B NKX2-2 BDNF GATA3 SNTA1 GATA2 SCN4B HDAC9 NKX3-1 YBX1 TLX3 POU3F2 PHOX2B C4B_2 SST POU2F2 C4A IL6R TCF3 DLX2 HIF1A G6PC1 GCK TF RORA MAP2 PAH IL10 HEL-S-162eP IL13 CXCL8 CHRNB2 CPT1A ECE1 EN1 BHLHB2 CREM PPARGC1A IL1RN EGR1 FREP1 IL1A AQP4 TACR1 SLC9A3 FOXM1 VEGFA TPH2 POU5F1 TPH1 ChAT GRIN1 FEV CTNNB1 PKNOX1 TNF TSPYL1 CHRNB4 DEAF1 SPTBN1 PHOX2A SOX2 MYB NR3A2 CC2D1A HEL2 NOS1AP KCNJ8 GPD1L HEL-S-125m LMX1B AVP CHRNA7 PPARGC1B HADHB 5HT1A GJA1 NR3C1 HDAC1 NEUROD1 HES1 NFYA HES5 NFKB2 PRKAR1B PRKAR1A REST SP3 RET ACADM CHRM2 SCN5A TP73 CASP3 HTR2A JUN NFKB1 SLC25A4 IL6 NTRK2 SP1 DDC NR1A2 MAOA HEL-S-87p ADCYAP1R1 VIPR2 GNB3 SNAP25 PBX1 SSTR2 RYR2 SLC1A3 YWHAQ TH HEL-S-1 YWHAG YWHAZ NGF CREB1 RUNX3 IL1B HSPD1 VAMP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2C19 CYP2C9 CYP2B6 CYP2C18 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 TMEM120B MDH2 TMEM120A SSC4D POR RAF1 STYXL1 HEL163 PTPMT1 KIF1C SFN EPB41L3 YWHAG LMNA RHBDD2 ZP3 ZP2 HEL-S-102 DAPK2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling STAT2 STAT1 MAPKAP1 GAB2 MAP3K1 VAV1 ZAP70 TYK2 SOCS3 SOCS1 IRS1 MAP2K3 EIF4EBP1 PTPRC FYN MAP2K6 RPTOR PTPN11 MAPK14 PTPN6 MLST8 EIF4E EIF4B RPS6KA4 RPS6 IRF9 RPS6KA5 RPS6KB1 PRMT1 REL LCK PIK3CD STAT3 STAT4 IFNAR2 CRK PIAS1 IFNAR1 RAP1A CRKL MTOR PIK3R2 PIK3R1 EIF4A1 RAPGEF1 CBL CREB1 RAC1 JAK1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD AGPS LPIN1 IPMK LPIN2 PIK3CA HMFN0839 PLA2G2A PI4K2A PTDSS1 CHKB PCYT2 PTPMT1 GPAM PEMT MOGAT3 GPD1 CHPT1 PGS1 CEPT1 CRLS1 GPAT2 GPAT4 CDS2 PIP5K1A GNPAT CDIPT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA CMKLR1 PIK3CD FPR2 EPHB2 MTOR GRK1 LTB4R HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 CD36 HIF1A HEL-S-133P PPARG GPD1 HEL-S-49 HEL-S-162eP NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2 POLA1 MTHFD2 OAZ1 DHFR HPRT1 POLG RRM2B ADSL NME2 SRM IMPDH1 ADSS FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 FABP4 CEBPA KLF5 INS PIK3CA GATA3 GATA2 PLIN1 NR1C1 MGLL KLF2 LMNB2 PNPLA2 PPARG LPL LIPE ZMPSTE24 FNTA BANF1 LMNA CIDEC ICMT PRRX1 STAT5B CIDEA SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 SLC6A19 FURIN ACAT1 CTSL TMPRSS4 ACE2 NRP1 TLR7 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP1 AGPS LPL GPAM MOGAT3 GPD1 LIPF LIPE AGPAT4 AGPAT5 MOGAT2 MOGAT1 AGPAT3 DGAT1 GNPAT LIPC DGAT2 PLPP3 PNPLA2 PLPP2 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 TIFA UBE2V1 NFKB1 SQSTM1 PRKCZ HEL-S-71 TRAF6 IL1A AJUBA SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RAF1 RASGRF1 HTR2B NRAS HTR2A GATA4 MAPK1 KRAS MAPK3 HRAS MAP2K1 MAP2K2 MAPKAPK2 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade MAPK10 MAP2 ARAF MBP NRAS BRAF MAP3K1 MAP3K2 JUN LAMTOR3 RRAS MAP2K3 MAPK1 MAP2K4 MAPK12 KRAS SOS2 MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 RASA3 RAF1 SIPA1 PLCB3 HRAS GRB2 MAP3K12 SOS1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 PIK3CD PTGS2 BAX CRP CCND3 COL4A1 HMOX1 PTGS1 IL6 NFRKB AKT3 CXCL8 TNF LAMA3 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing OAS1 TREX1 RNASEL ADAR RNASEH2C IFNB1 RNASEH2B RNASEH2A MAVS RNASET2 CGAS RIGI MITA IFIH1 IRF3 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies USP9X ADCY6 XPNPEP3 DYNC2I2 CEP19 INVS NPHP3 DYNC2H1 DYNLT2B SUFU DYNC2LI1 KIF7 OCRL RP1L1 IFT172 PKD1 DNAJB13 PIK3R4 RSPH9 SMO AHI-1 IFT81 TCTN3 CENPF GPR161 TCTN2 INTU TCTN1 RSPH3 ALMS1 HEL-S-296 IFT27 CC2D2A RPGRIP1L RSPH1 TMEM138 SPAG1 NPHP1 TULP1 PIBF1 CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 C2CD3 B9D1 RAB23 B9D2 CCDC41 KIAA0753 CCDC40 OFD1 ANKS3 BBIP1 PDE6D NEK9 PLK4 ZNF423 CRX TRAF3IP1 CEP164 FLCN IFT52 TMEM107 ODAD1 CNGA1 ODAD3 NEK1 ODAD4 BBS9 CCDC28B BBS7 MCIDAS IFT57 NME7 TBC1D32 BBS5 NEK2 CEP290 DNAAF3 DNAAF2 ZIC2 BBS4 DNAAF6 IQCB1 CFAP418 FAM161A CCNQ IFT140 IFT80 CCNO CFAP410 AK7 CEP78 WDR35 LZTFL1 DNAAF19 ARL2BP EVC DNAL1 BBS10 DNAAF11 IFT43 HYDIN BBS12 CCDC39 RP2 MAK CFAP52 DNAI2 TMEM216 TOPORS EFHC1 WDPCP RP1 NME9 WDR51B CNGB1 ZMYND10 SDCCAG8 CEP104 KIZ ARL6 CFAP53 ARL3 KATNIP DNAH6 PKD1L1 PKHD1 CFAP298 ARL13B POC1A TMEM67 RAB28 INPP5E DNAI1 EVC2 TUB BBS2 DYX1C1 NEK8 RPGRIP1 BBS1 TTLL5 PCARE HYLS1 SCLT1 ATXN10 DCDC2 TTC8 MKS1 CEP41 TRIM32 GLI3 CLUAP1 DRC1 CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis SCARB1 NR1H4 LDLR SLC22A1 ABCC2 ABCB4 SLCO1A2 HMGCR ABCC3 ABCB11 EPHX1 RXRA NR1I3 ABCG8 ABCG5 ATP8B1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 GOT2 SLC25A12 GLUD1 SLC25A13 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYP11A1 SRD5A2 POR HSD17B6 STAR AKR1C4 AKR1C2 HSD17B3 CYP17A1 HSD3B2 FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism RELA INSR CRP FLAD1 DHFR INS CSF1 TNF GPX1 CCL2 HEL-S-44 SCARB1 APOB SERPINA3 LDLR SLC19A1 MTRR SAA4 HBB MTR PLAT FOLR1 PLG HEL-S-51e MPO MTHFD2 ABCA1 FGA HBA2 GPX6 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG ALB SAA1 SAA2 GPX4 GPX2 CBS NFKB1 IL2 IL4 IL6 CTH MTHFS SLC46A1 IZUMO1R FOLR3 MTHFD1 FOLR2 GPX3 SHMT1 IL1B INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB1 PAK1 ARHGEF7 VASP CAV3 BRAF VAV2 CAPN3 DOCK1 SRC SHC1 ZYX PDPK1 AKT3 MAP2K3 MAPK1 MAPK12 FYN MAP2K6 MYLK2 MAP2K1 SHC3 MAP2K2 HEL-S-28 RAF1 HEL114 ITGB3 ITGA2B RAC3 PXN CAPN10 ITGA1 PAK6 SELENOP PAK4 ITGA2 ITGA4 MAPK10 ITGB7 MAP2K5 ARAF RHO CRK ROCK1 CAPNS1 ROCK2 MAPK7 RAP1A CAV2 TLN1 PIK3R2 CDC42 RAPGEF1 MYPN ITGAM ITGB5 ITGB4 CAPN9 CAPN6 ITGAE CAPN7 CAPN5 ITGB8 TNS1 ITGAV GIT2 ITGAX ITGB6 CAPN11 VAV3 MAPK6 ITGA7 ITGA6 MAPK4 RAC1 HRAS CSK GRB2 SOS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIST1H4L H2BC12 CHAF1A RBBP4 HIRA H4C9 SMIM40 IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling TICAM2 RELA CEBPB FAS CTNNB1 CSN2 MAPK1 TNF MAPK3 IL18R1 NFATC4 NFKBIA ELAVL1 IL37 PRKAA1 TNFSF6 NCF1 RPS6KB1 PRKCB MAP3K7 IRF1 PRKCA ACACB HEL-S-102 LCK CYCS GSK3B IRAK1 MAPK9 MYD88 CASP3 CHUK IL18RAP BAX TRAF6 TNFRSF1A GATA1 NFKB1 SP1 CASP8 PIK3R1 PARP1 NCF2 IMP3 SLC12A3 GRIN2B PTEN IL18 IKBKB NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium GSK3B MAP1B MEF2C GHRL NGFR APP ID2 ASCL1 MAP2 STAT3 CXCL12 MRE11A ID1 BDNF KDM1A PLXND1 CDK5R1 MYC NTRK2 PAX6 NRG1 ERBB4 DAB1 AGRN SOX2 DISC1 NUMB NOTCH1 PSEN1 PAFAH1B1 NEUROD1 RTN4 NDEL1 HES1 TCF4 LRP8 NTRK1 TCF3 NEUROG3 FAIM NTRK3 NGF RELN VLDLR CDK5 IL17A RET RTN4R CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K1 IGF1 TGFBR1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 NFATC2 MAP2K1 MAPK14 MAP2K2 CDK9 EGF RAF1 IKBKE FGFR2 MAP3K7 PRKCA PRKD1 GSK3B MAP2K5 MAP4K1 MAPK8 TGFB1 CHUK IKBKG TNFRSF1A MAPK7 NFKB1 MAP3K14 MTOR CALM1 CDK7 FGF2 NPPA GUCA1A IKBKB PPP3CA RAC1 CAMK2D 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome METTL27 STX1A FKBP6 VPS28 ATPAF1 TRIM50 HDAC2 FBLN2 ATP8 FBLN5 ATP6 MVB12A CLASP2 ATP5MC2 TMEM270 TBL2 ATP5MC3 GTF2IRD1 FAS CTNNB1 CLDN1 MYC ATP5G1 PRKG1 NRG1 HDAC6 MAPK3 ABHD11 TSG101 ACACA MLXIPL H2AX USF1 HEL-S-123m FBN1 EIF4H ATP5PB EIF2A ATP5F1D GTF2I ATP5F1E SQSTM1 ACACB ATP5PO RB1 BTK SF3B1 ATF4 MYBBP1A HEL-S-15 HMGA1 RFC2 CHTF18 CLDN3 UBE2L6 CDKN1C HEL-S-162eP MYO1C CLASP1 DLD LIMK1 GRIP1 ULK1 SNAP25 CLDN5 CLTC PCNA CLDN4 BRD4 LAT2 PKLR NUP62 DDX21 UBIAD1 FZD9 OGDH BAZ1B BCL7B BUD23 VPS9D1 HDAC3 ATPAF2 UBE2E3 SMARCA5 VPS37C HSPA2 DEK HEL-S-271 UBE2E1 VPS37D GRB2 VPS37A HOXC8 VPS37B CLIP2 VAMP2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB4 TLR4 CAMK2A PLCB1 PLCB2 STAT2 STAT1 IFI44L NRAS IFI27L2 CAMK2G RSAD2 TYK2 ISG15 CYP27B1 RXRA MAPK1 TNF NR1i1 MAPK12 KRAS MAPK3 MAPK13 CCL2 MAPK11 MAPK14 CAMP OAS2 DEFB4B CD40 PRKCH IFNGR2 PRKCB PRKCE PRKCA NFKB2 CD40LG IFNG PRKCQ SP3 RXRB NOD2 PRKCZ MAPK9 RXRG CYP24A1 MAPK8 RELB PLCG2 IFNAR2 IFNGR1 JUN TNFRSF1A MAPK7 NFKB1 IL6 SP1 CXCL8 IFNA2 PLCE1 PLCB3 IKBKB JAK1 HRAS CAMK2D TLR8 MED1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17RA IL17A SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 HMGB1 IKBKB THBD CHUK RELA NFKBIA IKBKG AGER MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression GABPB1 TFAM PPARGC1B MYEF2 HCFC1 POLRMT GABPA MTERF3 MTERF1 NRF1 SP1 CREB1 PPP3CA PPARGC1A TFB1M TFB2M PPRC1 ESRRA CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network RAD54B SMUG1 REV3L ERCC2 POLI FANCD2 FAN1 H2AX FEN1 MPG PNKP OGG1 NBN UNG RFC1 POLD3 POLD4 NTHL1 DDB2 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 NEIL2 APEX1 POLE3 RAD52 CHEK1 WDR48 XPA XPC CUL4A ERCC5 RFC2 GTF2H2C_2 CCNH MSH6 GTF2H2 FAAP24 GTF2H3 MSH2 BRIP1 GTF2H5 FANCM MNAT1 CENPX RAP1A FANCL REV1 WRN FANCA POLM NHEJ1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C PARP2 ERCC1 CENPS CETN2 CDK7 ATM ATR BRCA1 BRCA2 POLD2 XRCC5 TDG POLE4 MRE11A MSH3 DDB1 RAD50 CUL4B RAD51 HMGB1 RPA3 RPA1 MGMT POLK RFC3 RFC4 RBX1 PRKDC PCNA PARP1 TERF2 PMS2 USP1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF5 MED23 TAF8 MED27 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 MED30 MED31 POLR2M POLR2L TAF10 TAF11 MED14 TRFP CRSP9 TAF1 TAF4 TAF3 POLR2A THRA CDK8 POLR2D GTF2B TAF9 CTDP1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TAF13 MED15 TAF7 TAF6 TBP CCNC TAF12 MED9 NELFB NELFCD NELFA POLR2C MED1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1D HTR1B HTR1F GNAI1 STAT3 BRAF HTR2A MAP3K1 GNAI3 PIK3CA MAPKAPK3 PDPK1 RAP1A MAP2K3 MAPK1 ARHA MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 GNAO1 5HT1A RASGRF1 RPS6KA5 FOS CREB1 MAPKAPK2 HTR1E GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS ALDH5A1 GAD2 GLS2 GAD1 PON3 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 PARP1 NAMPT SIRT1 SIRT3 SIRT6 NADK NRK SIRT4 NT5E SIRT5 SIRT7 NMNAT3 NMNAT2 SIRT2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GCK UXS1 PGM3 HK3 HK2 GFPT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB GC CYP27B1 CYP24A1 RXRA DHCR7 NR1i1 PTH CYP27A1 CYP2R1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH RAF1 PRKAA1 NFKB1 PRKCA DUOX1 RAP1A CLCN5 CREB1 HEL-S-5 PRKAA2 SLC5A5 MAPK1 DUOX2 MAPK3 TSHR MAP2K1 TG MAP2K2 CGA TPO NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6R IL6 SOX4 IL11 STAT3 RELA IL11RA JAK1 JAK3 IL6ST PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 PTGER1 PTGER3 PRL PTGS2 ANXA6 EDNRA AKR1C1 AKR1C2 S100A6 SOX9 EDNRB CYP11A1 ANXA2 PPARGC1B PPARG PTGFR HPGD AKR1B1 EDN1 PTGS1 HEL-S-7 TBXA2R PTGDR PTGIR PTGIS PTGFRN PPARGC1A ANXA3 PTGER4 ANXA4 ANXA1 SCGB1A1 PTGER2 S100A10 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A8 SLC30A2 SLC30A5 SLC39A14 SLC30A4 SLC30A1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC39A8 MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACSL3 HSD17B10 EHHADH ACADSB ACADL DECR1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling ADCY3 PLCB1 MYL12B GNG2 STAT1 BRAF IGF1R SRC PDPK1 CDK4 MAP2K3 CDK2 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 RAF1 CDKN1B RPS6 CCND3 RPS6KB1 RBL2 RB1 APEX1 KCNIP3 GNAI1 STAT3 TSHB RAP1GAP SCRIB GNAI3 PIK3CA RAP1A GNB1 GNAS TSHR MTOR CGA GNAO1 PIK3R2 PIK3R1 CCNE1 RPS6KA1 PDE4D GNA13 CREB1 JAK1 HRAS PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NOTCH1 RBPJL CTNNB1 FGF10 PTF1A PDX1 RBPJ KAT2B PROX1 NKX6-1 HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MMP9 SRD5A2 CREBBP SIRPA EP300 CHD2 SOX5 TRIP13 ERCC2 CYP26B1 HLA-DRA PON2 CDK9 PON1 APOB TMEM132E CYP17A1 RFC1 PEX10 AHR HMGA1 XPC CCNK PRDM9 REC8 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 SPATA17 TSSK4 DDX4 DAZ4 THBS1 DAZ3 VCX DAZ2 CLU MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 FOLH1 PIWIL4 GNAO1 SPO11 XRCC3 HORMAD2 MSMB ERCC1 PRMT6 PACRG TEX15 CXXC1 ABLIM1 OR2W3 P1 USP26 NQO1 CDC42BPA MDM2 MLH3 ATM CTCFL ABCB1 SEMG1 CYP1A1 BRDT BRCA2 MMP2 DND1 FAT10 XRCC5 INSR PSAT1 KDM3A FAS AHRR UBE2B TNF MAS1L GPX1 NR3A2 BCL2 MTRR SLC16A7 NFE2L2 MTR TNFSF6 TCN2 MSH4 HEL-S-61p AGO2 STRA8 POLG HEL110 NOS2 PARP1 SLC46A1 PEMT MTHFD1 SHMT1 H4C9 DAZL PMS2 H3-4 ETV5 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease ANGPT2 SMAD2 LTBP1 SMAD4 MAPK8 NR2C2 RUNX2 FBN1 TGFBR3 CTGF FBN2 TGFBR1 FBN3 LTBP2 SHC1 MAPK1 FLNA ENG MAPK3 POSTN MAPK14 TGFBR2 AGTR1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 CS SDHC SDHD SDHB SDHA OGDH ACO2 IDH3B FH SUCLA2 DLD SUCLG2 SUCLG1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN ACE2 VEGFA NRP1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 HSD11B2 EBP SLC27A5 THEM5 DHCR7 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 ACOT9 AMACR ACOT6 SLC27A2 NPC1 ACOT4 DBP CYP7A1 EPHX2 CYP27A1 NPC2 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway MMP9 EGFR SMAD2 RELA STAT1 INSR TIRAP INHBB FOXO1 SRC INS SHC1 IRS1 MAPK1 MAPK3 ATF2 HEL-S-44 MAP2K1 MAPK14 NFKBIA RAF1 ALPL NCF1 AGER PRKCB PRKCA HIF1A STAT5B EZR CYCS IRAK4 CASP9 PRKCZ MAPK9 MAPK8 MYD88 CASP3 CHUK STAT3 ROCK1 JUN NFKB1 SP1 CASP8 ARHA NOS2 CDC42 FOXO4 DDOST HEL70 MSR1 MMP7 IKBKB MMP2 RAC1 MMP14 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 ABCC2 SLC51A SLC51B SULT2A1 ABCB1 BAAT ABCC3 SLCO1B1 ABCB11 CYP3A4 NR1I3 NR1i1 CYP7A1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 CDKN1A HIF1A ABCB1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation HEL70 CNP MBP GAP43 FREP1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome NKX2-5 CDC45 CYP26A1 HIRA HIRIP3 PAX3 CYP26B1 GBX2 HEL25 SLC2A4 CYP26C1 FGFR2 SREBF2 TBX1 GSC2 HAND2 PAK4 CDH15 ACTA2 RORC CLDN3 PARK2 SLC25A1 HEL-S-80p DGCR8 DROSHA CRKL GP9 SNAP29 PLK1 SERPIND1 SEPT5 TXNRD2 TSKS ZDHHC8 RCC1 C22orf39 DRD2 THAP7 TSSK2 RTL10 HDAC3 NPRL2 TRMT2A ESS2 KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L GP1BA TNPO1 ASF1A SCARF2 EGFR DGCR2 GP1BB C16orf35 SLC7A4 GNB1L DEPDC5 FOXC2 CCDC188 FOXC1 ARVCF RANBP1 P2RX6 SHH ZNF74 PITX2 FGF10 CLDN1 NCOR1 BCL2 RAF1 FOXA2 RTN4 HES1 ALDH1A2 EMC10 POLR2A RELN RTN4R RBX1 MED15 FGF8 CLDN5 CDC42 UFD1L FGFR1 GLUD1 H4C9 CLTCL1 VWF RAN SHOC2 PRODH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling EGFR CREBBP STUB1 SMAD4 EP300 RUNX2 RELA FHL2 FOXO1 EFCAB6 HEL32 SRC KAT7 KDM1A PIAS2 CTNNB1 ZNF318 FKBP4 RNF6 RNF4 TGFB1I1 BAG1 FLNA PATZ1 NCOR1 SMIM40 UBE2I SUMO1 SIRT1 HDAC1 TGIF1 RB1 PAK6 KAT2B CCND1 ZMIZ1 GSK3B RAD9A STAT3 TLE5 PIAS1 ROCK1 KAT5 ROCK2 UBE3A JUN HEL-S-99n PSMC3IP SP1 ARHA RLN1 PIK3R2 NCOR2 PIK3R1 CDC42 NR2C2 RHOB MDM2 CCNE1 HEL-S-67p NR0B2 PTEN BRCA1 CREB1 RAC1 RAN SIN3A CARM1 LIMK2 NCOA1 SMARCE1 ETV5 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFD HEL-S-62p ICMT LMNB2 RCE1 FNTA LMNA CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 MDH2 ALDH7A1 HEL-S-5 GCDH L2HGDH D2HGDH APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3B BCL2L1 BCL2 BCL2L2 BAK1 ITGB4 BAX BOK PTHLH GSK3A MYC AKT3 BCL2A1 BCL2L10 ITGA6 BCL2L12 BCL2L14 MCL1 BCL2L13 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis GAD2 PAH GAD1 ASMT TH TPH1 ChAT AANAT DDC ACHE MAOA HDC PNMT DBH LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 TRIM71 EGR1 SOX2 POU5F1 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ITGB1 MYL12B DCC SLIT1 SHH SLIT3 TRPC1 SRC PDPK1 MAPK1 MET FYN RYK gdf7 SEMA5B RHOD ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 RAF1 ABLIM3 ROBO2 LRIG2 CXCR4 SRGAP2 NTNG2 NGL1 SLIT2 EPHA2 PRKCA WNT4 NTN3 PARD3 CDK5 ARHGEF12 GSK3B RGMA HEL-S-15 PRKCZ EPHB1 GNAI1 CXCL12 ROCK1 NRP1 PARD6A RRAS PLXNA1 PTCH1 EFNA1 CDC42 SEMA3A BOC L1CAM FES FZD3 ROBO1 NCK1 BMPR2 RAC1 HRAS CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NCOA6 ABCC2 DNAJC7 SULT1A1 FOXO1 UGT1A4 CYP2C19 SP1 CYP3A4 RXRA NR1I3 UGT1A3 CYP2C9 CYP2A6 CYP2B6 SULT2A1 UGT1A1 EHHADH ABCB1 UGT1A9 ABCC3 SMC1A PTPA PPARGC1A CYP4A11 ALAS1 NCOA1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 OAS1 STAT1 IFI35 IRF9 IFIT3 IFNAR2 PIAS1 IFNGR1 IFNGR2 TYK2 IFIT1 IRF1 IFNAR1 IFITM1 PSMB8 SOCS1 IFNG JAK1 MX1 TAP1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FST SMAD4 KRTAP8-1 BMP6 IGF1 MSX2 EGR2 BMP4 SFRP1 CD200 PERP GATA3 CTNNB1 CD34 CASP14 MSX1 SOX2 SOSTDC1 TP63 NOTCH2 ADAM17 NOTCH1 ZBTB16 WIF1 NR3C1 LEF1 HR Nbla10317 ATL1 HOXC12 KRTAP3-3 PHLDA1 IGFBP5 KRTAP15-1 SPINK6 SPINK5 TCF4 ADAMTS20 DSG1 TCF3 DSG4 IFNG GPR49 DLX3 KLK5 KLK4 GPRC5D LRIG1 KRTAP6-1 FOXE1 KRTAP2-4 GSDMA KLK13 KLK14 FOXN1 GTPBP4 KRT19 GJB6 KITLG GAS1 DKK3 FOXQ1 CTGF JUN NFATC1 NFKB1 DKK1 DKK4 RBPJ SMAD1 ELANE SOX9 DSC2 FZD1 BMPR1A FOS S100A4 RUNX3 KLK6 CD133 FOSB ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1A2 RELA CHUK GUCY1B1 IKBKG TMPRSS2 HMOX1 NFKB1 IL6 CXCL8 RXRA TNF CCL2 ACE2 GCLM NFKBIA GCLC NFE2L2 NQO1 SLC7A11 IL12A IKBKB IL1B MMP3 IRF3 KEAP1 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B10 UGT2B4 PGM2 UGT1A8 PGM5 UGT2B7 UGT1A3 UGT1A10 UGT1A1 UGT2B28 UGT1A9 UGT1A5 UGT2B11 UGT1A4 UGT2B15 UGT2B17 UGT1A7 UGT2A2 PGM3 UGT2A1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 MTR FOLR1 MTHFD1 MTHFD2L SHMT1 HEL-S-51e TYMS MTHFD2 DHFR HEL-S-70p MTHFS FTCD IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 HSCB ABCB7 FDX1 NFU1 FDXR CIAO2B FXN ISCU NUBP1 NUBP2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF EGFR RAF1 CASP3 HTT RPS6KA5 BDNF NTRK2 CREB1 MAPK1 MAPK3 HRAS MAP2K1 MAP2K2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND2 PRL EPOR STAT1 STAT3 EPO CISH NRAS PRLR FOXM1 IFNGR1 SOCS2 CDK4 SOCS3 IL6 SOCS1 AKT3 KRAS RPTOR GHR MTOR MLST8 GH1 CCND3 IFNGR2 AKT1S1 IL6R IFNG STAT5B HRAS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH ME1 BRAF HEL-S-32 PDP2 ME2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 UGT2B4 CYP8B1 SLC27A5 ABCB4 SULT2A1 NR0B2 SLCO2B1 BAAT ABCB11 FGF8A FKBP5 CYP3A4 RXRA PPARGC1A IP6K3 CYP7A1 NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation TLR4 COX1 MAPK8 CHUK RELA JUN ASCC1 FOS NOS2 MAPK14 MTOR NFKBIA COX2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CREB1 MTR ADH5 CEBPB CBS CYP2E1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ASS1 ARG2 GLUD1 ARG1 ALDH18A1 SMS OTC HEL-S-29 HEL-S-5 SRM HEL-S-20 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFB10 NDUFB11 CEBPA COX7A2 NDUFV3 NDUFV2 SOCS3 NDUFC2 NDUFC1 PRKAA2 NDUFS6 NDUFS5 NDUFS4 CCL2 NDUFS1 COX2 NDUFB9 BCL2L11 NDUFB8 PRKAG1 NDUFB7 PRKAG2 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 PRKAG3 NDUFB1 BBC3 NDUFA7 LEPR NDUFA6 PRKAB2 NDUFA5 ZNF183 NDUFA3 PRKAB1 NDUFA2 IL6R PIK3R3 ADIPOR1 NDUFAB1 ADIPOR2 VCAM1 MAPK9 MAPK8 TGFB1 BAX COX7B COX4I1 COXFA4L2 COX6A1 CXCL8 DDIT3 CASP8 COX8A PIK3R2 COX6B1 PIK3R1 COX7A1 SDHC XBP1 SDHD UQCRB SDHB COX3 CYP2E1 UQCR11 UQCR10 GSK3A CYB UQCRH UQCRQ UQCRC1 IKBKB UQCRFS1 CYC1 RAC1 UQCRC2 IL1A BAK1 INSR RELA INS FAS NR1C1 AKT3 IRS1 RXRA TNF MAP3K5 MAP3K11 ERN1 NR1H4 MLXIPL PRKAA1 TNFSF6 COX4I2 NR1H3 EIF2S1 CYCS ATF4 GSK3B LEP COX1 PIK3CD CASP3 TRAF2 SDHA JUN TNFRSF1A NDUFC2-KCTD14 PIK3CA COX6B2 NFKB1 COX7B2 MLX IL6 COX8C MLXIP UQCRHL NDUFA13 CDC42 PKLR COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 IL1B NDUFA9 NDUFA12 NDUFA10 COX6A2 ITCH COX7A2L SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B2 SLCO4C1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 NR3A2 SULT1E1 HSD17B1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 B3GALT2 B3GALT1 FUT3 FUT1 FUT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin ANGPT2 ANGPT1 VEGFA GATA2 CX3CL1 CCL8 CCL5 MAP2K4 HLA-G CCL7 TNF MAPK3 CCL2 IL15RA CCL4 MAPK11 NR3A2 BCL2 PGR CXCR4 NR3C1 IFNG STAT5B JAK3 MCL1 VCAM1 IL2RB ITGA4 IL15 IL2RG CXCL12 IL10 IL4 IL6 CXCL8 GAB3 NCR2 MADCAM1 KIR2DL4 IL3 SELL CD69 PIBF1 JAK1 CXCR3 CXCL11 NCR1 NCR3 CCL3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 CHDH SLC44A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ITGB1 CLDN4 ZEB2 TGFB1 ALPL SFRP1 TERT MYC ITGA6 TNF NRG3 ERBB4 CCND1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK1 TLR4 IRAK4 IRF7 MYD88 CHUK TRAF3 TIRAP TRAF6 TBK1 IKBKG MAP3K7IP1 TRAM1 NFKB1 IL6 CXCL8 TNF INPP5D NFKBIA IRAK3 IKBKE RIPK1 MAP3K7 TICAM1 IFNB1 IKBKB IRF3 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell AP3D1 ARCN1 SPCS3 NEDD4 LAMTOR5 HEL-S-30 MET POGLUT3 AXL TPM3 TPM1 GYS1 RAB34 TMEM59 MAP3K8 NCL PTMAP7 RHEB LAMC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 SDCBP GAS2L1 TNFRSF10B VCAM1 HMGA1 SLC4A10 NF2 TBCA CHMP2A SRPRB DKFZp761E1322 PICALM THBS1 ADAR SYNE2 TUBA1A FBXW11 SMAD1 CTDSP1 SIGMAR1 SEC23A HSD17B12 UBE2J1 DNAJB1 POLR2C SPTLC1 POLD2 TGFBR2 SH3BP4 ATP6V1C1 ATP6V1F GFPT1 PDLIM7 SLC12A2 GALNT7 GALNT1 ATP6V0E1 FMNL2 CPNE8 VEZT CUL4B BET1 PWP1 PNP DHX57 CIAO2A GOLGA7 FNDC3B FNDC3A PISD RTN4 POM121 HES1 MRPL20 COMMD9 SLC38A1 PEDS1-UBE2V1 MOV10 RARS1 ANP32B RNP24 NRP1 HEL-S-26 ARF4 TRAM1 HMOX1 MAGT1 MRC2 TMEM43 HOXA7 SH3BGRL3 TMED7 ANXA2 E2F3 ATP2A2 ELOVL5 AP2A1 PRPF40A YWHAQ CSDE1 FGF2 P4HA2 PXDN MRPS33 AKAP8 PPP1R7 MPZL1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MCAT HSD17B12 ACACA MECR OXSM HTD2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-117 ADH6 ALDH2 HEL-S-53e HEL-S-4 CYP2A6 CYP1A2 CYP1A1 CYP2E1 ADH1A ADH1C CYP3A4 CYP4A11 ADH7 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB NR1B3 RXRG RARA RXRA RARB DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 FST TGFB1 ANOS1 CELSR1 BMP4 SHH SPRY1 GRIP1 PAX2 SIX1 SMAD1 BMPER SMO GPC3 CRIM1 BMP7 BMP5 CTDNEP1 RARA HOXD11 FRAS1 HOXA11 FREM1 FREM2 GLI3 SALL1 ETV4 SIX2 BMPR1A BMPR2 NR1B3 EYA1 GDNF BMP2 CCND1 DCN RET ETV5 RARB HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis FECH UROD UROS HMBS CPOX ALAS1 ALAS2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex FLT3 GABPB1 BCL2L1 BCL2 SMARCA4 CREBBP ETV6 SMAD4 EP300 FOXO3A ZFX ATM GABPA PTEN TERF2 DNMT3B MCL1 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism ADSL PNP HEL-S-70p XDH AMPD1 APRT IMPDH1 ADA ADSS DGUOK HPRT1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling ITGB1 MAP4K1 MAPK8 PAK1 PTGS2 STAT3 CRK JUN DOCK1 SRC PIK3CA RAP1A HGF MAPK1 CRKL MAPK3 MET PTPN11 MAP2K1 MAP2K2 RAPGEF1 RAF1 PXN FOS PTEN ITGA1 PTK2B HRAS GRB2 SOS1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK1 TLR4 IRAK4 IRF7 MAPK8 MYD88 RELA CHUK TRAF3 RELB TRAF6 IKBKG IL10 MAP3K7IP1 NFKB1 IL6 CXCL8 TNF CCL4 ELANE MAPK14 NFKBIA TLR7 MAP3K7 IRF1 NFKB2 IKBKB LCN2 REL TLR8 CCL3 VCAM1 IL1A AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy DKFZp762B153 RB1CC1 WIPI2 ATG5 ATG14 AMBRA1 PRKAA2 RPTOR MTOR ULK1 PIK3R4 DEPTOR PRKAG1 MLST8 PRKAG2 ATG3 PRKAG3 PRKAA1 ATG9A ATG12 PRKAB2 ATG16L1 PRKAB1 AKT1S1 ATG101 UVRAG PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling P2RY11 ADORA2B GNAI1 P2RY6 P2RY4 P2RX6 GNAI3 P2RY2 P2RY1 PANX1 GNAS GNAO1 ADORA2A P2RY10 P2RY14 GNAZ P2RY8 GNAT2 GNAT3 GNAT1 LPAR4 P2RX7 P2RX5 GNA11 P2RX4 P2RX3 P2RX2 P2RX1 P2RY13 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions TLR4 NLRP3 MMP9 EGFR SMAD2 CNP EBI3 SIRPA FAM20C STAT1 PDGFA MBP CD47 IGF1 VEGFA TGFBR1 NKX2-2 IL10RA FOXO1 IGF1R MOG TYK2 PDGFRA OLIG1 CX3CR1 OLIG2 SOCS3 TNF CCL1 MAPK14 CTLA4 NKX6-1 CCL20 IL33 CSPG4 ITGB3 CD80 HEXB IL10RB IL12A CD68 NFKB2 IFNG STAT5B ITGA2 JAK3 OSM IL2RA IL2RB CD44 IL2RG MYD88 TGFB1 STAT3 CXCL12 TGFBR3 STAT4 IL12RB1 IL10 CCR8 FOXP3 NFKB1 HTR7 IL2 IL4 IL6 SPP1 NOS2 SOX9 PDCD1 CDC42 SSTR2 FOXO3A FOXO4 ROS1 ITGAV IKZF2 IL18 AIF1 CCN3 NKX6-2 TNFRSF1B IL1B KLRG1 RAC1 APOD MCAM JAK1 GSDMD TMEM119 TGFBR2 CXCL1 AREG CCR6 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome CDKL5 KCNJ10 XAB2 MEF2C TBL1XR1 IMPDH2 CHD4 HAP1 SCN8A HTT ACTL6B BRAF CRK SCN1A GABBR2 SCN2A HDAC5 HDAC8 SYNE2 GNAO1 NCOR1 STXBP1 NCOR2 SRRM3 SMARCA4 TAF1B FOXG1 HDAC1 SHANK3 SMARCA1 SMC1A TBL1X GRIN2B TCF4 SYNGAP1 EIF2B2 GABRA3 KDM5B TRRAP GPS2 RHOBTB2 CECR2 HIVEP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MEF2C MIXL1 MESP1 THY1 NKX2-5 NCAM1 INHBA SIRPA IGF1 ZFP42 BMP4 POU5F1 ISL1 INS KDR PDGFRA PAX6 NRG1 GATA4 SOX1 SOX2 MAPK14 TBXT NOTCH1 BMP1 CXCR4 MESP2 FOXA2 IGF2 TBX20 IRX4 TBX5 KIT MYL2 WNT3A TNNI3 GSK3B SOX17 SCN5A TGFB1 LIN28A LIN28B ROR2 DKK1 NODAL FGF2 NOG MYH6 MYLK3 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade SERPINB2 F13B PLAT KLKB1 PLG FGA VWF F2 HEL-S-78p KLNA1 F7 SERPINF2 F3 F5 F10 F8 F11 F9 WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling CAMK2A CCND2 DAAM2 PRICKLE2 GPC4 CAMK2G CTBP2 NFATC3 NFATC2 NFATC4 INVS WIF1 CCND3 MAP3K7 CCND1 MAPK9 MAPK8 FZD10 ROR2 FRAT1 FRAT2 CSNK2A1 CSNK2A3 NFATC1 CSNK2A2 CSNK1E DKK1 DKK2 DKK4 SFRP4 CSNK2B PPP3R1 PPP3R2 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 PPP3CA RAC1 PPP3CC PLCB4 PLCB1 PLCB2 DAAM1 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CHD8 RYK ROR1 WNT5B SOST LEF1 NKD1 NKD2 PRKCB DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 WNT3A VANGL1 KREMEN1 SENP2 SFRP5 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 ROCK2 JUN WNT16 NLK LRP5 LRP6 ARHA APC CTBP1 PLCB3 CAMK2D ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling CPT2 ME1 RXRB CD36 RXRG FABP4 DBI PLIN1 NR1C1 PDPK1 ANGPTL4 UCP1 RXRA APOA5 OLR1 APOC3 FADS2 SCD CYP7A1 APOA2 CYP27A1 PCK1 HEL-S-28 CYP8B1 PLTP FABP1 PPARG SLC27A5 LPL SLC27A1 EHHADH CPT1C NR1C2 UBC NR1H3 SLC27A4 CYP4A11 PCK2 ACSL1 ACOX1 AQP7 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling CAMK2A EGFR PAK1 NRG4 NRAS BRAF CAMK2G FOXO1 SRC SHC1 PDPK1 MYC AKT3 NRG1 HBEGF ERBB2 MAP2K4 NRG2 EIF4EBP1 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC4 SHC2 MAP2K1 SHC3 MAP2K2 TGFA BCL2L11 ERBB3 EGF RAF1 RPS6KB2 CDKN1B RPS6KB1 PRKCB PRKCA PIK3R3 PAK6 PAK4 STAT5B CCND1 GSK3B PIK3CD MAPK10 MAPK9 MAPK8 ARAF PLCG2 CRK JUN PIK3CA NRG3 CRKL BAD MTOR PIK3R2 PIK3R1 MDM2 CBL EREG BTC NCK2 NCK1 CDKN1A ABL2 HRAS CAMK2D GRB2 AREG SOS1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNT1 ACTA2 MYL3 TNNT3 MYH8 HEL113 MYL1 MYOM1 MYBPC3 TNNC1 TNNI1 ACTN2 DMD HEL-S-273 HEL-S-108 ACTN4 TTN ACTG1 tmp_locus_29 TPM3 TPM1 TMOD1 TCAP MYH6 ACTA1 MYL4 TNNI2 MYL2 TNNI3 TNNC2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 OXCT1 ACAT1 UCP2 BDH1 SLC25A20 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 SRD5A2 POR AKR1D1 AKR1C4 HSD3B1 SULT2A1 HSD17B3 CYP17A1 HSD17B2 AKR1C1 CYP3A7 AKR1C2 CYP3A4 HSD17B4 HSD17B1 HSD3B2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology HEL-S-15 ADCY3 ADCY1 SMAD2 ADCY8 SMAD4 ADCY6 WWTR1 TGFB1 LBR NRAS SYNE4 CTGF SYNE3 SUN1 YY1AP1 PLEC HEL-S-7a SYNE2 MAPK1 SYNE1 ARHA KRAS SOS2 MAPK3 TMEM43 HEL-S-61 MAP2K1 MAP2K2 BANF1 EMD ADCY9 LEMD3 HRAS GRB2 SOS1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m ERN1 ASNS NFE2L2 DNAJB11 BBC3 XBP1 SULT1E1 HEL-S-89n EIF2A EDEM1 HEL-S-99n DNAJC3 ERP27 TRIB3 DDIT3 DNAJB9 UBE2E1 PPP1R15A BCL2L11 NARS1 ATF3 ATF4 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL SMAD2 PARP1 SMAD4 TGFB1 PPARG FBN1 ZMPSTE24 FNTA BANF1 LMNA INS KCNJ6 MUCL3 SPRTN ICMT LMNB2 WRN FFAR3 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1A2 CAMK2A NPPB CASP9 PDE3A RELA PBR GUCY1B1 CAMK2G GRIN1 NFKB1 CNGB1 ACTN2 DLG4 CNGA3 CNGA4 AKAP9 TNF CNGB3 NEFL NOS2 PDE2A BAD NFKBIA CALM1 BCL2 NPPA GRIN2B IFNG CREB1 IL1B CNGA1 CAMK2D CYCS AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG2 PRKAG3 PRKAA1 SIRT1 PRKAB2 RPS6KB1 PRKAB1 PRKAA2 PMAIP1 PPARGC1A MAPK3 RPTOR HEL-S-32 MTOR PARP2 PRKAG1 MLST8 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA ACTA2 SMAD2 CASP9 SMAD4 CASP3 BAK1 TGFB1 APAF1 TRPV5 BAX BRAF TGFBR1 PDE1B TNFRSF1A PIK3CA MAPK1 CASP8 SEC16B MAP3K5 HEL-S-41 MTOR FFAR3 PPP3R1 RAF1 TNFSF11 PTH MCU FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP9 MAPK8 PAK1 CASP3 APAF1 CASP10 FAF1 MAP3K1 JUN DFFB MAPKAPK3 DFFA FAS ARHGDIB LMNB2 MAP2K4 TNF CASP8 RIPK2 NFX1 SMIM40 PRKDC BCL2 FADD PARP1 ACTG1 SPTAN1 TNFSF6 CASP6 PS1TP5BP1 LMNA MAP3K7 ACTA1 RB1 HEL-S-102 MAPKAPK2 CYCS IL1A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network ADORA2B BTG2 AURKA PML ZMAT3 PERP LIF ISG15 FAS CX3CL1 TP53I3 CDK2 PRKAA2 TNF GPX1 CCL2 RPTOR SMR3B DEPTOR ACAD11 SERPINB5 PRKAG1 MLST8 SCO2 PRKAG2 ADGRB1 NOTCH1 DRAM1 RPRM SIVA1 MGMT ULBP2 PRKAG3 ULBP1 SESN2 PRKAA1 BBC3 TP53AIP1 IRF9 PIDD1 TNFSF6 DDIT4 SESN1 TIGAR FUCA1 PRKAB2 CPT1C PRKAB1 AKT1S1 SLC7A11 DDB2 RRM2B PMAIP1 TNFRSF10B TRAF4 CCNG1 POLK TSC2 XPC ERCC5 APAF1 BAX SFN MSH2 THBS1 FANCC ULK2 ULK1 MTOR GADD45A PCNA TNFRSF10D NCF2 CCNE1 E2F7 CDKN1A PTEN GLS2 TP53INP1 XRCC5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap MAT1A CDO1 ADK MTR CTH HEL-S-182mP HEL-S-61p CBS BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 SST FOXO1 SFRP1 DKFZp781O1323 CTNNB1 DKK1 WNT4 SMAD1 BMP2 DCN LEFTY2 BCL2L11 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CA HLA-DRB1 PIK3CD PIK3R3 CD80 PPP2CA PTPN11 CTLA4 PTPN6 PIK3R2 PIK3R1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT1 HEL-S-277 PRMT7 NOS2 CARM1 PRMT3 PRMT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 HGS RAF1 ARAF PDCD6IP BRAF NRAS RAB5B RAB5C RRAS2 RRAS MAPK1 KRAS RAB27A MAPK3 HRAS RAB5A IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BIRC5 TGFB1 RELA CHUK STAT1 STAT3 RUNX2 PIAS1 SRC TYK2 PDPK1 SOCS3 IL11 MAPK1 IL11RA BGLAP FYN MAPK3 ATF1 PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2 YES1 RAF1 FES RPS6 RPS6KA1 RPS6KB1 IBSP PTPA IKBKB CREB1 JAK1 HRAS ITGA2 GRB2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COX11 ERBB2 MAPK1 ADRA2B ARHA MAPK3 CIAO2A ANKRD23 SNRNP200 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 DUSP2 CNNM4 FER1L5 STARD7 SEMA4C ARID5A COL2A1 ASTL NEURL3 ZP2 KANSL3 PLXNB2 MMS19 IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling GSK3B SPRED1 STAT1 STAT3 JUN SHC1 IL2 IL5RA MAPK1 CSF2RB KRAS MAPK3 PTPN11 MAP2K1 LYN MAP2K2 PIK3R2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 RPS6KA1 RPS6KB1 GSK3A JAK1 STAT5B BTK GRB2 SOS1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP3 CARD9 CARD6 ACAP1 NLRP10 NOD2 CASP9 NLRP7 NLRP2 NLRP12 RELA CHUK IKBKG NLRP1 NAIP CASP8 DUOX2 CASP5 RIPK2 NFKBIA NDUFA13 PRDM1 AIM2 PYCARD COPS6 IL18 IKBKB IL1B RAC1 NOD1 NLRC4 MEFV AAMP CARD8 ERBIN LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PDE3B RELA SH2B1 STAT1 CISH FOXO1 SRC SHC1 SOCS2 SOCS3 IRS1 ERBB2 PRKAA2 EIF4EBP1 MAPK1 FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 MAP2K2 EIF4E SOCS7 ACACA RAF1 PRKAA1 RPS6 LEPR RPS6KB1 ACACB REL STAT5B CFL2 KHDRBS1 GSK3B LEP KPNA4 MAPK8 CHUK STAT3 PLCG2 IKBKG ROCK1 PLCG1 ROCK2 NFKB1 SP1 ARHA BAD MTOR PIK3R2 PIK3R1 CDC42 RPS6KA1 GSK3A PTEN IKBKB CREB1 RAC1 JAK1 HRAS GRB2 NCOA1 SOS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC1H1 DYNC2H1 DYNLRB2 IFT46 DYNLT1 IFT140 DYNC1LI2 IFT81 DNCL1 DYNLT3 IFT80 WDR35 IFT27 DYNLL2 IFT25 IFT43 DYNC1I1 DYNLT2B IFT22 DYNC1LI1 DYNC2I2 DYNC2LI1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine HEL-S-7a ADRB1 ADCY3 ADCY1 ADRB2 ADCY8 ADCY6 ADCY9 ADRA2C ADRA2B ADRA2A ADRA1D PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCC2 CYP24A1 ABCD2 CYP26A1 NR1C1 CYP27B1 CYP3A4 NR1I3 NR1i1 ABCG5 CYP7A1 ABCD3 NR1i2 NR1H4 CYP8B1 RARA CYP2C9 PPARG ABCB4 CYP2B6 CYP1A2 ABCB1 ABCA1 CYP2E1 ABCC3 CYP4B1 NR1C2 ABCG1 ABCB11 NR1B3 NR1H3 CYP4A11 RARB HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA2 PDHA1 ACACA NFE2L2 PRKAA1 RPS6 VEGFA PRKAB1 ACACB EGLN1 HIF1A HEL-S-133P SLC11A2 PRKAG1 KEAP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 AKR1D1 AKR1C1 AKR1C4 AKR1C2 CYP3A4 CYP11B2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTC4S DECR2 ALOX5 ABCC1 ALOX5AP PTGR1 DECR1 CYP4F3 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX VLDLR NDEL1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP HIST1H2BE CDKN2A FZR1 RPS6KA2 RELA CEBPB UBE2D1 EHMT1 CDK4 RPS6KA3 CDK2 MAPK1 MAPK3 H2BC21 H2AX CDKN1B UBB ANAPC1 CCNA2 RPS27A CDKN2D CDKN2B CDKN2C H3C8 CDC26 STAT3 VENTX ANAPC15 C10orf104 UBE2S CDC27 JUN UBE2C MAPK7 NFKB1 H3C15 IL6 CXCL8 CDK6 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 RPS6KA1 H2BC8 CDC23 H4C9 H2AC6 HIST1H4L ANAPC7 FOS H2BC3 ANAPC5 UBC H2BC1 CDKN1A ANAPC2 H2BC17 H3F3B H2BC12 ANAPC11 H2BC13 H2AJ H2BC14 UBE2E1 H2BC15 IGFBP7 H2AC20 H2BC11 IL1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways NADSYN1 TDO2 NMNAT1 IDO1 PARP4 PARP1 NAPRT NAMPT BST1 SIRT1 SIRT3 TNKS2 SIRT6 SIRT4 HEL-S-90n SIRT5 SIRT7 TNKS PARP2 SIRT2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HEXA HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB GLB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases MMP16 MMP9 MMP15 MMP23B MMP17 MMP19 TCF20 MMP26 TNF TIMP4 TIMP3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 hEMMPRIN MMP7 MMP2 MMP3 MMP10 MMP12 MMP11 TIMP1 MMP14 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 SMAD4 BMP6 RUNX2 IGF1 BMP4 DKFZp781O1323 BHLHE41 HMGB1 CSF1 PRKAA2 CTF1 LAMP2 NOTCH1 BCL2 CRY1 ATG3 BMP5 SP7 SOST ATG12 PTH TNFRSF11B CTSK ATG16L1 ATG101 PLEKHM1 CTHRC1 MAP1LC3A SQSTM1 ATG10 BMP2 PER1 CALCA LEP DKFZp762B153 RB1CC1 TGFB1 TRAF6 WNT16 VCP RORB NFATC1 BMP3 ATG5 DKK1 IL6 LRP5 AMBRA1 ARHGAP4 FYCO1 DRAM2 SMAD1 SEMA4D ULK1 MTOR IL3 SEMA3A SMAD9 TNFSF11 WNT10B EFNB2 BHLHB2 TNFRSF11A NPAS2 BMPR2 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity PCNA KDR BDKRB2 CYP3A4 MAPK1 PTK2B HEL-S-44 MAP2K1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 ABCC2 CYP2C9 UGT1A3 CYP2A6 CYP2B6 SULT2A1 DNAJC7 UGT1A1 ABCB1 UGT1A9 FOXO1 ABCC3 SRC SLCO1B1 UGT1A4 CYP2C19 CYP3A7 CYP3A4 RXRA PPARGC1A SRPX2 CYP4F12 NCOA1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKD3 ADCY3 ADCY1 PDE4A ADCY8 ADCY6 GNA14 GNG3 GNG5 GNG4 NRAS GNG7 GNG8 PDE1C AKAP5 PDE1B AKAP10 PDE1A PDE8A AKAP9 KRAS PDE7B PDE7A GNAZ PRKACG PRKCH PRKCB GNG10 GNA11 PRKCE GNGT2 PRKCA ADCY9 PRKAR1B GNAL PRKAR1A PRKCI PRKCQ PRKD1 PRKCZ GNAI1 GNAI3 GNG12 GNG11 GNG13 KCNJ3 GNA15 RRAS GNB2 ARHA GNB1 GNAS HEL159 GNB3 AKAP12 GNAO1 AKAP11 GNB5 AKAP7 AKAP6 CALM1 AKAP4 GNGT1 PDE4B PDE4D ARHGEF1 AKAP8 GNA13 PLCB3 PPP3CA PPP3CC HRAS ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling CHEK1 RAD9A MAPK9 TP73 MRE11A MDC1 IKBKG JUN CASP2 RAD50 TP53BP1 RAD51 CDK2 CRADD ATF2 GADD45A MDM4 H2AX PIDD1 MDM2 CCNE1 ATM TLK1 NBN RIPK1 SMC1A CDKN1A BRCA1 CCNB1 CREB1 CDC2 CHEK2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 FADD CASP9 CASP3 APAF1 TNFSF6 CASP6 MAP3K1 TNFRSF1A CASP2 RIPK1 NFKB1 FAS CASP8 AIFM1 CYCS PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC35B2 CANT1 BPNT2 PAPSS2 CHST3 XYLT2 XYLT1 CHSY1 CSGALNACT1 B3GAT3 SLC26A2 B3GALT6 EXT2 CHST14 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP1 AXIN1 TNK2 TNK1 BTRC SKP1 DVL1 CTNNB1 DVL2 RBX1 DVL3 PARP10 APC PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection HLA-DQA2 HLA-DQA1 HEL113 STAT1 VEGFA HLA-DRB1 FAS PDGFRA HLA-B HLA-F CCL19 HLA-G TNF HLA-DOA HLA-E HLA-DRA HLA-DOB CTLA4 AGTR1 HLA-DPA1 HLA-DQB1 CCL21 HLA-DMB C1QB HLA-DPB1 C1QA CD40 LRRK2 TNFSF6 CD80 C4B_2 C2 C4A C8A IL12B IL12A CXCR5 HEL-S-62p CD40LG IFNG GDNF HARS1 IL17A IL2RA C1QC IF2B1 HLA-DRB5 CASP9 PRKCZ IL-21 CASP3 TGFB1 HLA-DMA CXCL12 PRF1 IL10 IL13 CSNK2A2 FOXP3 HLA-A IL2 IL4 IL5 TUBA1B CXCL8 C6 C7 CASP8 HLA-C C9 CD55 GNLY BHMT2 PECR ABCB1 GABPA IL1B MICA CXCL9 CXCL13 CXCL11 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome SNRPN NUP133 CDKN2A CCND2 PCM1 NUP98 RAE1 BDNF INS CDK4 DLX5 HEL-S-71 MSX1 HERC2 EIF4E TACR3 POM121 RNF8 PCSK1 RB1 CDKN2B CDKN2C CCND1 GHRH BBS4 GHRL PRKCZ AHCTF1 KISS1 UBE3A TUBGCP5 NIPA1 NDN TUBGCP6 TUBGCP4 NIPA2 FSHB GABRG2 SNURF ATP10A NUP85 TPR LHB CGA NUP107 CDK6 MDM4 POMC OXT NUP62 GNRH1 NUP188 NPAP1 NUP214 NDC1 MAGEL2 MDM2 GOLGA8S NUP88 GABRB3 NUP210 CYFIP1 GOLGA6L2 GABRR3 NUP93 FEZ1 FMR1 GABRR1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 GABRA5 NGF SEH1L AAAS GABRG3 NUP160 GABRG1 NHLH2 NUP42 RANBP2 NUP155 CDC6 NUP153 TYR NUP35 MKRN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway COL1A1 LAMA5 LAMB2 COL3A1 IL2RG ZAP70 TNFRSF1A THBS1 IL2 IL4 VTN IL5 IL5RA COL1A2 LAMB1 CD40 CD80 LAMC2 LAMC1 CD40LG IFNG TNFRSF1B LCK THBS3 IL2RA IL2RB GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG8 ALG9 ALG2 TUSC3 ALG14 ALG13 ALG3 B4GALT1 ALG12 ALG11 DPM3 DPM2 GCS1 DPM1 MAGT1 ALG1 ALG6 MGAT2 SRD5A3 DOLK DPAGT1 MPDU1 GMPPB CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CALM1 ATP2A1 HDAC2 CD8B1 MEF2D EP300 HDAC1 CD8A CABIN1 PLCG1 ZAP70 PPP3CA PPP3CC NFATC2 LCK ITPRIP RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway RS1 ANGPT4 BIRC5 ANGPT2 TNIP2 ITGB1 TNIP3 EGFR ANGPT1 PAK1 RELA NRAS GRB7 FOXO1 SRC RAD51 CTNNB1 MYC ERBB2 EIF4EBP1 MAPK1 MAPK12 KRAS MAPK3 MAPK13 PTPN11 MAPK11 MAPK14 NFKBIA GRB14 PXN STAT5B CASP9 MAPK9 MAPK8 CHUK STAT3 BAX YAP1 CRK IKBKG MSH2 PIK3CA NFKB1 NOS2 BAD PIK3R1 NCK1 IKBKB MMP2 RAC1 HRAS GRB2 SOS1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 NOP2 CDKN1B FLT1 FOXO3A GAB2 ABCB1 LYL1 SKP2 PDGFRA CSF1R MYC ABCG2 KIT BCR GADD45A CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EGFR CREBBP KDM5C EFCAB3 FLT1 PBRM1 EP300 SDSL PGBD5 LDHD VEGFA PSAT1 CAMK1 PSPH ENO1 KDR KSR1 HEL-S-68p SETD2 BHLHE41 PDGFRA HEL-S-30 SSPN RPTOR PHGDH DEPTOR MLST8 ACACA FASN HEL-S-51e GRB10 RHEB BAP1 AKT1S1 LDHB SQSTM1 ACACB HIF1A HEL-S-133P HK3 HEL-S-32 CEP290 KCNJ2 ME1 PGM2 MAP2K5 TSC2 TSC1 STAT3 HEL-S-162eP PFKL ACLY ENO2 PFKM ENO3 PLOD2 PFKP HEL-S-49 HEL-S-87p ENPP3 HK2 VHL MTOR RAPGEF5 PKLR ALDOB SHMT1 PTEN HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 FGF20 THEM4 ATP6V1H MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 MAPK3 PTPN1 INSR PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 KLB FLT3 IRS1 PDE3B IRS2 PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 PTPRF FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 TRIB3 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 ABCA3 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2C GRIN2B NRGN GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer MAPK1 PIK3CB PIK3R2 PIK3R1 PIK3CA MAPK3 CLIP1 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC25A15 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 DEFB4B S100A8 LTF TLR2 S100A7 DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation PLK1 TCF7L2 CCNB1 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B TBX2 HINT1 CCND1 SIN3A CDK2 CTNNB1 MET RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 ATF5 ATF3 ATF4 GRB10 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements YWHAB HSPB1 ELAVL1 PSMD8 PSMD6 ZFP36 PSMD7 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 CCNB2 NEK9 CCNB1 NEK6 NEK7 CDK1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle HNRNPC CCT7 RBMX DBN1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA UBC ZBP1 TREX1 RPS27A DDX41 DTX4 TBK1 IRF3 STING1 NLRP4 UBA52 TRIM32 TRIM21 TRIM56 UBB CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG4 GUSB ARSB IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 CDKN1A DEK FLI1 KLF5 H2AC20 LEF1 CDK2 CEBPB MYC E2F1 TFDP1 TFDP2 CDK4 H2AX CSF3R SPI1 GFI1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TAL1 H2BC11 RARA CEBPA KMT2A CBFB CEBPE GATA2 H3C15 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling RXRA SCD FASN CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 FABP6 EP300 APOC2 APOC1 AGO1 ANGPTL3 AGO2 PLIN1 TNRC6A ABCG1 TNRC6B BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SRD5A3 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage XIAP CYCS CASP9 CASP7 APAF1 CASP3 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 CCNE1 STAT3 HDAC3 GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 RAC1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 ACTB CLIP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS GLUD1 GLUD2 KYAT1 RIMKLA GLUL RIMKLB PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 PLCG1 FGF20 FGF16 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development DLL1 POU3F3 WNT4 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling NTRK3 NTF3 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 YWHAB RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB RAPGEF3 SIPA1 RAPGEF4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide CA4 CA7 CA6 CA9 CA14 CA13 CA12 CA1 CA3 CA5B CA2 CA5A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 DICER1 TARBP2 TSN AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HBEGF EGFR HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia ARG1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CCT6A HSP90AA1 CDC37 HSP90AB1 RNF20 TWF1 SPEN MSI2 CCT2 RHOBTB2 CPSF7 ROCK1 ACTN1 ROCK2 TMOD3 GPS1 DDX39B CUL3 PHIP TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 ACTG1 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS1 GINS2 CDC45 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA AKT2 STRADB TSC2 TSC1 PRKAB1 YWHAB RPS6 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 AKT1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle TIAM1 ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 PIK3R2 NOXA1 PIK3R1 ABI1 NOX3 ESYT1 FERMT2 NOX1 ABR MCF2 CDC42 LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SRGAP2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 DIAPH3 ITGB1 GIT2 VAV2 CAV1 MCAM LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR2 TGFB1 TGFBR1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 HMGA1 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 TP53 H1-5 H1-4 HIRA UBN1 EP400 ASF1A INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway IL36B IL36G IL36RN IL1F10 IL1RL2 IL36A DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions DSCAM DCC DSCAML1 NTN1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle ARHGAP26 BAIAP2 VANGL1 ARHGAP32 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 DAAM1 CDC42EP3 TRIO CDC42EP2 RASGRF2 WAS ITSN1 PARD6A PLEKHG4B CHN1 PAK6 PREX1 STOM MCF2L PAK3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 CDC42BPB SRGAP2 ARHGEF10 CDC42BPA ARHGEF12 DEF6 PLEKHG2 KTN1 ARHGEF15 SHKBP1 DLC1 ARHGEF16 ARHGEF19 DIAPH3 VAV2 TIAM1 ARHGEF9 ARHGEF4 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF ARHGEF6 ARHGEF26 FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 MCF2 CDC42 FMNL3 FMNL1 FMNL2 LAMTOR1 TFRC SNAP23 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 SYDE1 ARHGAP42 OPHN1 ARHGDIB LBR GIT1 TMPO ARAP2 ARAP3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A ARHGAP17 ARHGAP21 PAK1 RACGAP1 PAK2 YKT6 PAK4 GIT2 CAV1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 NCAM1 ITGA5 ITGA9 EGFR CSNK2A1 CSNK2A2 PAK1 MAPK1 RAC1 CSNK2B NRP1 MAP2K1 MAP2K2 MAPK3 ITGB3 ITGB1 ITGA2B L1CAM VAV2 ITGAV MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal MGMT MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBC RPS27A UBA52 UBB ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans NCAM1 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TGFB1 TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 TNXB LRP4 ACAN TGFB2 LUM TGFB3 DSPP COL9A1 COL9A3 COL9A2 AGRN FMOD NCAN BGN DCN BCAN VCAN LAMA5 LAMA2 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN DAG1 ITGB3 ITGB1 ITGA2B ITGAV SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins H4C9 HDAC1 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I HDAC4 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 NUP205 CBX5 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis GCKR GCK PPP2R5D PRKACG PRKACA PRKACB PPP2CA PPP2CB HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 NUP37 PGK2 PFKL GNPDA1 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1 SUMO3 SUMO2 UBE2I SUMO1 RWDD3 UBA2 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes CREBBP SP1 BCL2 PDGFA MAFK AREG EGF NFE2L2 BCL2L1 EP300 NOTCH1 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN6 TNFRSF14 PTPN11 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR3 TAC3 TACR1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K NTF4 NTRK2 BDNF GAB1 PIK3R1 PIK3CA ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism GPT ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 HBEGF AREG EGF EGFR AKT2 CDKN1B MAPK1 CCND1 TGFA XPO1 FOS FOXO3 ELK1 SRF PTK2 AKT1 EREG MAPK3 UHMK1 BTC EPGN AKT3 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway ADCY5 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis GNG13 GNB2 PPP2R5B GNB1 PPP2R5A PPP2R5D PPP2R5C GNB4 GNB3 GNB5 GNGT1 GUCY1B2 GNGT2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PDE5A PLA2G4A PTPN11 FGR STIM1 KCNMA1 PPP2CA ORAI2 PPP2CB PECAM1 ORAI1 PDE9A PDE1B GNG3 PDE1A ITPR1 ITPR2 GNG2 ITPR3 GNG5 SRI GNG4 LRP8 GNG7 PDE11A KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 APOB TRPC7 NOS2 NOS3 PDE2A TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 PDE10A P2RX3 P2RX2 P2RX1 GNAS PPP2R1B PPP2R1A PTPN6 MAPK14 GNG10 GNG12 PPP2R5E GNG11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TRMT5 TYW2 TYW1 LCMT2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization CIDEC HILPDA CIDEA FITM1 HSD17B13 FITM2 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation UBC RPS27A RAB7A KPNA1 UBA52 ATP6V1H NOS2 VPS33B CORO1A HGS RAB5A KPNB1 UBB VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity UBC MAFK SKP2 RPS27A SKP1 RBX1 UBA52 FBXL17 BACH1 UBB CUL1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis OMA1 OPA1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ARHGAP10 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPK1 MAPK3 PPP2R1B PPP2R1A MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB ST6GALNAC3 MAN2A1 MGAT5 ST6GALNAC4 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC ST3GAL4 MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 ST6GAL1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors PTGDR PTGER4 PTGFR PTGER1 PTGIR TBXA2R PTGDR2 PTGER2 PTGER3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination HGS MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 TRIM25 NFRKB PSMD1 USP17L30 HIF1A YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 BRCC3 PSMA1 SNX3 RHOT1 PSMA2 RCE1 ZRANB1 UBA52 SIAH2 INO80 STAM PSMD12 TADA2B PSMD11 CYLD H2AC25 PSMD14 H2AC21 BAP1 PSMD13 WDR48 OTUD7A PSMA7 OTUD7B BABAM1 PSMB6 IFIH1 BABAM2 PSMB7 UCHL1 TRIM4 PSMB4 UIMC1 UFD1 PSMB5 ACTB IKBKG TOMM70 UBB RIPK2 PSMB2 ACTL6A PSMB3 JOSD2 UCHL3 UBC JOSD1 PSMB1 UCHL5 DDB2 RPS27A KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 RNF135 PSMC6 STAMBPL1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 MBD5 PSMC2 USP17L18 MBD6 USP17L17 TP53 USP9X USP17L19 MCRS1 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 IL33 USP3 USP2 MUL1 TGFB1 H2AC1 TGFBR1 CDC25A TGFBR2 FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 ABRAXAS1 SKP2 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B CDC20 NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 EP300 ASXL1 TNIP1 TNIP2 TNIP3 H2AC8 ASXL2 H2AC6 OTUD3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RHOA KDM1B AXIN1 APC UBE2D1 CDK1 BRCA1 BARD1 SEM1 CCNA2 CCNA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations POMK DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism GAMT GATM SLC6A7 SLC6A8 CKM CKMT1B SLC6A11 CKB SLC6A12 CKMT2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B EIF4E NUP214 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 UBB UBC RPS27A HSPA8 XRN2 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35C1 PDZD11 SLC25A5 APOD SLC25A4 SLC25A6 SLC35B3 LCN9 SLC35B2 SLC27A1 SLC35B4 SLC35D1 SLC35D2 LCN15 LCN12 SLC35A2 SLC35A3 SLC33A1 SLC5A6 ARL2BP LCN1 SLC29A4 SLC27A6 SLC28A2 SLC35A1 SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC27A4 ARL2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D CHRM2 HTR1A CHRM3 TAAR5 CHRM1 HTR1B CHRM4 TAAR2 CHRM5 ADRA2C HTR5A ADRA2B TAAR1 ADRA2A ADRB2 GPR143 ADRB3 HTR2B HTR2C ADRB1 ADRA1D HTR2A ADRA1B HTR4 ADRA1A HRH1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 INS MAPK1 MAPK3 PTPN1 PTPN11 SNW1 CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51D RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A YBX1 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 FGF16 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases LCK FYN FLT3LG FLT3 HCK SYK GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 F9 PROC F10 GGCX PROS1 FURIN PROZ F2 BGLAP GAS6 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA BCKDHB DBT DLD LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG LDLRAP1 AP2M1 CUBN CETP AMN ZDHHC8 APOA2 APOA1 LSR APOA4 PRKACG APOA5 NPC1 PRKACA SOAT1 PRKACB SOAT2 NPC2 APOE ANGPTL8 ANGPTL4 LPA CES3 ABCA1 SAR1B MTTP MYLIP LPL LMF2 LMF1 NR1H2 APOF APOC4 AP2S1 NR1H3 A2M LDLR GPIHBP1 FGF21 MBTPS1 APOBR APOC3 APOC2 AP2B1 APOC1 ANGPTL3 NCEH1 ALB ABCG1 P4HB MBTPS2 APOB UBA52 UBB UBC RPS27A VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 FLAD1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP1 MIP AQP11 AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions VASP FBLIM1 PXN TESK1 ILK PARVA PARVB FLNA FLNC ARHGEF6 RSU1 FERMT2 LIMS2 LIMS1 ACTN1 ITGB1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 ITCH PSMD14 SUFU BTRC PSMD13 NUMB PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP ELAC2 TRNT1 HSD17B10 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB ADCY1 ADCY8 CALM1 PRKAR1B PRKAR2B DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a MGAT2 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway FZD2 GNG13 FZD5 WNT5A FZD4 GNB2 PDE6G FZD6 GNB1 NFATC1 GNAO1 MAP3K7 GNB4 TCF7L2 GNB3 TCF7L1 GNB5 LEF1 GNGT1 TCF7 GNGT2 CTNNB1 PRKG2 TNRC6C MOV10 GNG3 AGO3 ITPR1 AGO4 ITPR2 GNG2 ITPR3 GNG5 GNG4 AGO1 GNG7 AGO2 TNRC6A GNG8 TNRC6B CAMK2A CALM1 PRKCA PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 GNG10 NLK PPP3R1 WNT11 PDE6B PDE6A GNG12 FZD3 GNG11 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing CPSF4 CPSF1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TYW5 NUP43 TYW3 RAE1 TRMT5 TYW2 NDC1 TYW1 RANBP2 SEC13 LCMT2 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TRMT10C PRORP ELAC2 TRNT1 HSD17B10 TP53RK CLP1 POP5 POP7 OSGEPL1 POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 RPP38 PUS3 METTL1 CSTF2 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU QNG1 TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 TSEN34 URM1 LAGE3 RPP14 TRDMT1 RTRAF TRMT10A ADAT1 NUP214 TPRKB TRMT1 ADAT3 TRIT1 ADAT2 XPOT TRMT6 FAM98B TRMT61A TRMT61B RAN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS HRAS SOS1 NTRK3 NTF3 NRAS ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 ATP2A3 SLC9B2 RAF1 ATP2A2 SCNN1G ATP2A1 SCNN1D SCNN1B SCNN1A ATP7A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPM1 ATP4B SRI TRPM2 ATP4A TRPM7 FXYD4 TRPM8 FXYD3 TRPM5 WNK1 TRPM6 FXYD2 TRPM3 WNK2 TRPM4 FXYD1 WNK3 TRPC7 FXYD7 TRPC5 FXYD6 MCOLN3 CUTC TRPC6 ATP2B4 RYR1 TRPA1 ATP2B3 RYR2 TRPC3 ATP2B2 RYR3 TRPC4 ATP2B1 UNC80 TRPC1 TRPV2 ATP7B TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN PDZD11 ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 TCIRG1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 ATP6V1E1 STOM ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 NEDD4L ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 SGK1 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 CAMK2B CAMK2D CAMK2A CALM1 CAMK2G UBA52 WWP1 UBB UBC RPS27A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBC RPS27A SMURF1 PARD6A CGN UBA52 F11R PRKCZ TGFB1 RHOA PARD3 TGFBR1 TGFBR2 FKBP1A ARHGEF18 UBB CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division PLK1 KIF23 PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 KIF20A ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling NRG1 PTK6 HBEGF EGF ERBB2 EGFR NRG3 EREG NRG4 BTC NRG2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism MOGAT3 MOGAT2 GPAM MOGAT1 PPP1CA ABHD5 FABP12 PRKACG GK3 GK2 PRKACA LIPE PRKACB AGMO GPAT2 DGAT2 GK DGAT1 PPP1CB FABP9 PPP1CC FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 FABP6 LPIN2 MGLL LPIN3 PLIN1 CAV1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP CITED1 CITED2 YEATS4 CITED4 TFAP2A TFAP2B WWOX EP300 TFAP2C TFAP2D TFAP2E ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP GPAM ERCC6 ANGPTL4 LPL RBM7 DPY30 CHD4 TBP EED SAP18 MTA2 CIDEC MTA1 MTA3 MED1 MORC2 ACSL1 ELOVL5 MED4 MED6 MED7 SCD ZNF141 HDAC1 ZNF382 SETD1B SETD1A SIN3A ZNF136 EHMT2 EHMT1 PHF20 ASH2L UBE2I ZNF28 AJUBA ZNF273 HCFC1 CCNH PPARGC1A PPARGC1B POLR2E ZNF264 POLR2F POLR2H POLR2K POLR2L GTF2H1 ZNF30 GTF2H2 ZNF257 GTF2H3 EZH2 GTF2H4 ZNF33A GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB ZNF331 MED16 ACTL6A MED17 MED12 MED14 MED13 KAT2B KAT2A MED10 ZNF324 MEN1 ZNF320 MED27 SIRT1 ZNF317 MED23 MCRS1 MED24 MED20 ABL1 ZNF547 ZNF224 MBD3 GATAD2B GATAD2A SUDS3 CDK8 CDK5 ZNF778 TADA3 ZNF454 OGT SIN3B WDR5 PSIP1 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 RB1 RBBP4 RBBP5 RBBP7 SMARCE1 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 CEBPA KMT2A H3C15 TDG RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 DEK H2AC20 ZNF418 HDAC3 GPS2 LIPE TBL1X ZNF354A DGAT2 NCOA1 ZNF649 FABP4 NCOR2 NCOR1 CHD3 TBL1XR1 LPIN1 MGLL CBX3 SUMO2 RRP8 SAP130 PLIN1 DPF1 HDAC2 PDK4 DPF2 KAT8 DPF3 SAP30BP HCFC2 SUZ12 WDR82 PAXIP1 PEX11A BAZ2A CBX5 KAT14 SETDB1 SS18L1 SMARCA5 ZZZ3 ARID1A TADA2A GSK3B ARID1B ZNF816 EZH1 PHF1 SUV39H1 SGF29 CD36 JARID2 NCOA2 ZNF610 SS18 NCOA6 SMARCB1 NCOA3 CCNC TET2 TET1 SF3B1 PPHLN1 BAZ1B TRIM28 PHF20L1 NR5A2 AEBP2 MTF2 TET3 PLIN4 PLIN2 MBD2 SMARCC1 MYBBP1A SMARCC2 MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 MTREX TASOR MBIP ZNF708 TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C SMARCA2 BCL7B SMARCA4 DNMT3B UBTF ZNF765 KDM6A DNMT3A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes PPARGC1A GCK FBXO32 G6PC1 CAT INS ABCA6 HDAC1 RETN POMC NPY SIN3A SOD2 PLXNA4 PCK1 NR3C1 FOXO4 ATXN3 TRIM63 SMAD2 SMAD4 AGRP SMAD3 FOXO6 FOXO1 HDAC2 IGFBP1 SIRT3 FOXO3 SREBF1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB AKT2 TSC2 TSC1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 HEXB ARSG HEXA ARSD B3GALNT1 GLB1L3 B3GALT4 M6PR GLB1L2 GALC GLA GLB1L GLB1 ARSB ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein PARP10 PARP6 GSK3A UBE2I PARP4 PARP16 GSK3B SUMO1 PARP9 PARP14 PARP8 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation NTRK1 KIDINS220 RAP1A CRK NGF BRAF YWHAB DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU FMO3 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death ITCH YWHAE YWHAQ YWHAG YWHAH UBE2L3 TNFSF10 UNC5A DAPK1 UNC5B DAPK2 DAPK3 FADD ELANE CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 APPL1 DFFB DFFA DBNL RIPK3 IL18 ACIN1 IL1A IL1B KPNB1 GAS2 PELI1 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 TICAM1 CHMP4C PKP1 CHMP4B CHMP4A LY96 SDCBP BMF MLKL BMX STK24 STK26 CHMP2B CHMP2A AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 CASP5 CASP4 PPP3R1 FLOT1 FLOT2 DNM1L DSP PDCD6IP OMA1 IRF1 OPA1 IRF2 DSG1 CHMP3 DSG3 CHMP6 CHMP7 PLEC UACA ADD1 BAK1 GZMB CDKN2A MAGED1 CTNNB1 MAPK8 BCL2L11 BAD CDH1 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 BBC3 UBC PSMB1 DSG2 RPS27A PRKN ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 PAK2 CASP9 CASP7 APAF1 DIABLO CASP3 XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC OGT TRAF2 HSP90AA1 KPNA1 CDC37 BIRC2 BIRC3 E2F1 TFDP1 TFDP2 ARHGAP10 AKT2 TP53BP2 OCLN TNFRSF10B TNFRSF10A STAT3 DYNLL1 DYNLL2 MAPK1 PPP1R13B TJP1 FAS FASLG MAPK3 PMAIP1 SATB1 CASP6 CASP1 APC STUB1 BAX TP63 BCL2 BCL2L1 SEM1 TP73 PTK2 AKT3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IFNG NFATC2 RUNX1 TNFRSF18 CTLA4 CBFB IL2RA FOXP3 IL2 CR1 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SRD5A3 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ST6GAL1 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 MVD ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1 AKT1 AKT2 AKT3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN NCSTN YWHAZ APH1B PSEN2 ADAM10 PSEN1 JAG1 APH1A DLL4 NOTCH4 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 AURKA PSMD14 PSMD13 PSMA7 PSMB6 FBXL18 FBXL7 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism HSPG2 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 IDUA EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 CTSL HPSE IDS THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOX1 TPO IYD DUOXA1 CGA DUOXA2 DUOX2 TSHB DIO1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 YAP1 TCF7L2 CDKN1A TCF7L1 SPP1 CDKN2A LEF1 TCF7 TGFB1 CCND1 MAMLD1 CTNNB1 BCL2L11 ITGAL RBPJ ITGA4 SMAD4 SMAD3 SMURF2 ZFHX3 SNW1 MYC SMURF1 HDAC4 TEAD1 SRC MDM2 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 BRD2 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 CCN2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 KRAS PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A KAT2B KAT2A EP300 JAG1 ADRM1 WWTR1 PSMC5 PSMC6 SEM1 PSMC3 RUNX1 PSMC4 PSMC1 RUNX3 PSMC2 TP53 MAML3 FOXO3 CBFB NOTCH1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions LCK FYN PECAM1 LYN INPP5D PTPN6 PLCG1 ITGB3 YES1 PTPN11 ITGAV LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants FLT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 ARHGEF6 BTK GNGT1 RHOA GNGT2 CDC42 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PAK1 PDPK1 PLCB3 PLCB1 GNG10 PLCB2 AKT1 GNG12 AKT3 GNG11 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 JAK2 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 P4HB PPIA SNRPA1 PAK2 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling CBL UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling PRKCA ADCY9 ADCY4 ADCY3 ADCY2 PLCG1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA CALM1 CAMK2G PRKCD DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets RPS6KA1 PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MEF2C MAPK7 MAPK14 MAPK11 MAPK1 ELK1 MAPK3 MEF2A RPS6KA3 RPS6KA5 PPP2R1B PPP2R1A RPS6KA2 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy PRKAG3 PLIN2 PLIN3 HSPA8 PRKAB2 PRKAA2 PRKAG1 PRKAB1 PRKAG2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions COL18A1 ITGA3 ITGB4 LAMA5 ITGA1 LAMA2 NID1 LAMB3 NID2 LAMC3 ITGA6 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 ITGA2 HSPG2 ITGA7 ITGB1 ITGAV BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism PDZD11 MCCC2 BTD SLC5A6 PC ACACA PCCA HLCS MCCC1 PCCB ACACB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 SEC11A SEC11C GATA4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events FOXM1 WEE1 LIN52 PLK1 CCNB1 EP300 CDC25C CENPF CDC25A RBBP4 CCNB2 LIN54 LIN37 MYBL2 LIN9 PKMYT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes H2BC9 H2AZ2 H4C9 PLK1 H2BC8 H2BC5 H2BC3 H3-4 CCNB1 H2BC1 H2AC20 RB1 CDK1 SET H2AX H2AB1 NCAPG2 H2AC19 SMC4 H2BC26 SMC2 H2AC14 H2BC12L NCAPH2 H2BC21 NCAPD3 MCPH1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT5A H3C15 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT6A STAT3 FBXL3 FBXL5 WRAP53 HDAC3 CCT2 KIF13A CCT3 SPHK1 SKIC2 CCNE2 TCP1 GBA1 CCNE1 DCAF7 CCT6B USP11 CCT7 FBXO4 AP3M1 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CCT8 CCT5 CCT4 FBXW2 NOP56 ARFGEF2 XRN2 GAPDHS FKBP9 TP53 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity PML TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 SRC TNRC6A TNRC6B CCND3 RUNX1 CCND2 CCND1 CDK6 CBFB PTPN11 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 CFTR STAM ACTB USP9X CCT6A TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 WWP2 WDR11 LETM1 TMEM59 VMA22 GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 ARMCX3 PKP4 RASAL2 STIP1 ACTG1 DDRGK1 PLXNA1 ANKRD26 NSFL1C CPD PLXNB1 ARHGAP11A ZNF512B CAPZB EFHD2 NCK2 DAAM1 WDR6 NCK1 DST PLEKHG6 NIPSNAP2 BLTP3B PARD6B SH3BP1 WHAMM WASF3 NDUFA5 PCDH7 SEMA4F SRGAP2 PTPN13 VAPB ATP6AP1 GOLGA3 CKB BAIAP2L2 KCTD13 FRS2 TMEM87A DIAPH1 GRB7 PIK3CA PIK3R3 SCFD1 DIAPH3 ITGB1 SPTBN1 CCDC88A ANLN FAF2 SOS1 KIF14 SH3RF1 NUDC AKAP12 HINT2 RAC2 MUC13 RHOG PIK3R2 RHOH PIK3R1 RHOF RHOC RHOJ RHOD RHOU RHOV RHOQ RHOA SAMM50 RHOB EMC3 MTX1 CAVIN1 MYO9A TRIP10 RTKN PRAG1 SYDE2 BASP1 ALDH3A2 ELMO2 DDX4 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 CDC42 PLD2 RHPN1 RHPN2 FAM83B ACBD5 MACO1 ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 DLG5 PICALM FMNL3 SRC DOCK5 DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 SOWAHC MTR TNFAIP1 RND2 RND3 RND1 CKAP4 SENP1 ZAP70 GFOD1 ALS2 PEAK1 NDUFS3 DOCK2 DOCK1 CCDC187 MOSPD2 FAM169A ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CSK FRS3 JAG1 LCK DBT CLTC HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 ARHGAP21 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 WAS PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 ARL13B RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 PRKCB CREBBP RUNX1 LGALS3 CBFB REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism WDR26 PDHB RMND5B LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GID4 GID8 UBC RPS27A PDK4 DLD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 CYP11B1 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC E2F1 RBBP4 E2F3 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PRKCB PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 PRKCA CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 PRKCG FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death JUN PRDX2 H2BC9 PRDX1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 CDC25B CDC25A LMNB1 BCL2L11 FASLG CDK5R1 RIPK1 CDK5 SUZ12 YWHAE TRAF2 EED CDC25C FADD GSDME C1QBP RBBP4 EZH2 GOLGA2 SOD2 CAPNS1 RIPK3 CAPNS2 CAPN2 RBBP7 CAPN1 CAST PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MLKL H2AC6 H2AC7 H2BC17 APP DNMT3B H2BC12 H2BC13 TRADD H2BC14 H2AJ DNMT3A H2BC15 TP53 CASP8 H2BC11 FOXO3 H3C15 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU PHB1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGF ERBB2 EGFR PLCG1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation FBLN5 LOXL1 ITGA5 LOXL2 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 FURIN MFAP5 BMP4 MFAP4 LOX MFAP3 MFAP2 FBN1 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization SGTA PEX10 PEX12 TOMM20 GFER GDAP1 PEX13 PEX14 OTC DHRS4 NUDT7 VAPA TOMM7 CRAT TOMM5 TOMM6 NOS2 STX5 CAT SLC25A4 SLC25A6 IDE PMPCB PMPCA SLC27A2 PECR SAMM50 ZFAND6 TOMM22 MTX1 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 SCP2 CHCHD7 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 CMC4 CMC2 PAM16 ECH1 PIPOX BCS1L GNPAT ACBD5 ACOT2 STX1A ACOT4 COX19 COX17 PEX11B ATP5MC1 TIMM50 BAG6 PITRM1 GRPEL1 ABCD3 GRPEL2 UBE2D2 LDHD UBE2D3 OTOF HMOX1 HACL1 HAO1 CYC1 DECR2 HAO2 DNAJC19 COA4 PRNP FIS1 EPHX2 IDH1 TYSND1 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 UBE2D1 AMACR DAO HSPD1 PXMP2 PXMP4 ACO2 ABCD2 UBA52 CROT HSCB SERP1 SEC61G TIMM17A TIMM17B GET1 SEC61B GET3 EMD ABCD1 COA6 GET4 CAMLG TIMM23 PEX2 TIMM22 HSPA9 PEX1 TIMM21 BAAT UBB TOMM70 PEX7 SLC25A17 ACOX2 ACOX1 UBC PEX3 EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PAOX NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 APP HSD17B4 TIMM10 DDO HMGCL ATP5F1A ATP5F1B USP9X UBL4A TIMM8B ATAD1 PEX16 TIMM8A PEX19 MTX2 IDH3G DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors F7 F9 PROC F10 GGCX PROS1 PROZ F2 BGLAP GAS6 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L PRKACA KIF7 PRKACB WDR35 IFT88 SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 GLI3 GLI2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 GNAS PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 BTRC NUMB PSMD13 OFD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PRKAR1B PSMC5 PRKAR2B PSMC6 PRKAR1A SEM1 PSMC3 PRKAR2A PSMC4 PSMC1 PSMC2 SKP1 CUL1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis AP2A1 AP2A2 AP2M1 ARF1 ATP6V1H CD4 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B HCK PACS1 ELMO1 RAC1 LCK CD28 FYN PAK2 DOCK2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction LCK RAC1 FYN PAK2 HCK DOCK2 ELMO1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 JUN PCNA COX5B COX5A PERP NPM1 COX6C TTC5 CCNG1 PRDM1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 NDRG1 HIGD1C CNOT10 CNOT11 TAF4B YWHAE PRR5 DYRK2 CHD4 TRIAP1 PIDD1 YWHAQ YWHAG ZNF385A YWHAH TBP TMEM219 TAF9 TAF1L AURKA MTA2 TAF15 TAF12 TAF13 TAF11 CARM1 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 PRDX2 PRDX1 PLK3 PRELID1 CDKN1A HDAC1 CDKN2A PLK2 CDK2 CDK12 CDK13 PRKAA1 PRKAA2 MDC1 ATF2 BTG2 MT-CO1 PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 RPTOR NOC2L CHM STK11 TNRC6C MOV10 MLST8 TAF7L SLC38A9 AGO3 ING5 AGO4 ING2 PRKAB2 PIP4P1 AIFM2 AGO1 TNKS1BP1 AGO2 TSC2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC MT-CO2 BRD1 MT-CO3 ELOB RHEB RRAGB ELOC RRAGD LAMTOR2 AKT1 MEAF6 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SFN BRD7 YWHAZ CCNH POLR2A POLR2B PRELID3A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K TIGAR POLR2L GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 POU4F2 SUPT5H HIPK2 GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB BBC3 UBC DDB2 RPS27A CASP10 CSNK2A1 MAPK14 MAPK11 CSNK2A2 CNOT6L TAF9B CSNK2B IGFBP3 KAT6A TP53 APAF1 CYCS USP7 PLAGL1 PMS2 USP2 RICTOR BID MBD3 MAP2K6 FANCI GATAD2B GATAD2A FANCC CNOT4 CNOT6 CNOT7 BCL6 CDK5 CNOT1 STEAP3 CNOT2 CNOT3 MDM2 MDM4 CNOT8 CNOT9 CCNT2 SESN3 PTEN SESN2 KMT5A GPX2 BNIP3L CDC25C RNF34 CDKN1B NLRC4 MSH2 E2F1 RBBP4 MAPKAPK5 DAXX TFDP1 RBBP7 CCNE2 TFDP2 RFFL CCNE1 PPP2R1B TXNRD1 PPP2R1A CPAP PML TAF10 TP53RK EP300 AKT2 TP53AIP1 CHEK2 SMYD2 COX7A2L PDPK1 TXN NUAK1 TP53BP2 BANP GADD45A BCL2L14 TPX2 ZNF420 BRPF1 BRPF3 TNFRSF10C TNFRSF10B PRMT5 TNFRSF10A PPP2R5C PRMT1 TNFRSF10D RGCC SGK1 PIN1 BIRC5 MLH1 PPP1R13B COX4I1 FAS COX4I2 PPP1R13L CDK5R1 AURKB PPP2CA PPP2CB FANCD2 COXFA4 RABGGTB COX7A2 RABGGTA COX7A1 CHD3 RRM2B PMAIP1 TP53INP1 HDAC2 TP53I3 E2F4 JMY E2F7 E2F8 CASP6 CASP1 CASP2 RBL2 RBL1 GPI CCNK CCNB1 GLS2 GLS CDK1 ARID3A BAX BLM TP63 MRE11 BRCA1 CTDP1 ELL WRN BRIP1 CCNT1 KAT5 SUPT4H1 ELOA EXO1 CHEK1 NELFB NELFCD RBBP8 NELFA NBN NELFE TOPBP1 L3MBTL1 ATRIP SUPT16H BARD1 CREBBP RFC5 RMI2 ELOA2 RFC3 SSRP1 CDK9 RFC4 RMI1 TCEA1 PCBP4 RFC2 TOP3A RPA1 HUS1 RPA2 CRADD RAD50 RAD51D TP73 COX7B RPA3 RAD17 FOS RAD1 CCNA2 ATM CCNA1 DNA2 COX7C RAD9B RHNO1 ATR COX8A RAD9A COX8C AKT3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D KIF17 GRIN1 RPS6KA6 DLG1 CASK GRIN2A LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIA3 CALM1 CAMK2G GRIA4 GRIN3B GRIN3A APBA1 CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 NBEA RPS6KA3 RPS6KA2 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity USP7 USP2 RICTOR TTC5 CCNG1 MBD3 PRDM1 MAP2K6 GATAD2B GATAD2A CDK5 MDM2 MDM4 TAF4B PRR5 DYRK2 CHD4 KMT5A ZNF385A TBP TAF9 TAF1L RNF34 AURKA MTA2 TAF15 TAF12 RBBP4 TAF13 MAPKAPK5 TAF11 DAXX RBBP7 TAF8 TAF7 RFFL TAF6 TAF5 PPP2R1B TAF4 PPP2R1A TAF3 TAF2 PML TAF1 PIP4K2A TAF10 TP53RK PIP4K2B EP300 PIP4K2C AKT2 CHEK2 SMYD2 PDPK1 NUAK1 TP53BP2 BANP MAPKAP1 TPX2 BRPF1 BRPF3 PRMT5 PLK3 PPP2R5C HDAC1 CDKN2A SGK1 PIN1 CDK2 PPP1R13B PPP1R13L PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 PPP2CA NOC2L STK11 PPP2CB MLST8 CHD3 TAF7L ING5 ING2 PRKAB2 PIP4P1 TP53INP1 HDAC2 PRKAB1 MTOR JMY BRD1 AKT1 MEAF6 BRD7 UBA52 CDK1 HIPK1 POU4F1 BLM POU4F2 MRE11 TP63 HIPK2 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 SUPT16H L3MBTL1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CSNK2A2 TAF9B RAD50 CSNK2B TP73 KAT6A RPA3 RAD17 TP53 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A AKT3 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation LTF REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity XIAP RNF146 TNKS PREX2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 STUB1 PSMA6 PSMA3 TRIM27 PSMA4 WWP2 PSMA1 NEDD4 MKRN1 PSMA2 FRK UBA52 PSMD12 USP13 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A AKT2 ADRM1 CSNK2A1 PSMC5 OTUD3 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 AKT3 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 CYP17A1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants FLT3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 GIT1 CALM1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMA1 KCNMB1 CHRNA9 CHRNA10 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MLH1 RPA3 EXO1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) STPG4 METTL23 YAP1 UHRF1 H2BC9 DPPA4 H2AZ2 DPPA3 H4C9 DPPA2 H2BC8 ZFP36L2 H2BC5 LEUTX H2BC3 PAIP1 NPM2 H2BC1 KDM4E TPRX1 AICDA SRPK1 H2AC20 H1-8 TPRX2 ZSCAN4 HIRA CNOT4 CNOT6 CNOT7 EIF4E DICER1 EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 CNOT11 KDM5B TEAD4 PABPN1 PABPC1 TET3 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 BTG4 CNOT6L EIF4A2 H2BC12 KDM5A H2BC13 EIF4A1 H2BC14 TUT7 KDM6A H2AJ TUT4 H2BC15 EIF4G1 DUX4 TP53 PABPN1L H2BC11 TPRXL EIF4A3 DUXA DUXB DIS3L2 KDM6B PRM2 PRM1 H3C15 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA1 GNG13 GNB2 GNB1 AP2A1 ADCY9 GNB4 GNAL GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 CHRNA9 RASGRF2 PRKAR1B PRKAR2B PRKCB PRKAR1A RAC1 HRAS PRKAR2A PRKX PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF9 NRAS GRIP1 MAPK1 GNAT3 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 CHRNA1 CHRNA3 PRKAA1 CHRNA2 PRKAA2 MAPK3 CHRNA5 CHRNA4 CHRNA7 PRKAG1 CHRNA6 PRKAG2 EPB41L1 PRKAG3 TSPAN7 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK4 GRIK1 PRKAB2 GRIA1 GRIK2 GABRR3 CAMK2B GRIA2 GABRR2 GABRR1 CAMK2D NPTN SRC ACTN2 PRKAB1 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B NRGN PICK1 GRIN2D GNAI3 AKAP5 GRIN1 DLG1 GNAI1 GRIN2A NCALD DLG2 GNAI2 DLG3 CHRND LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE PRKCA CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 GIT1 KCNJ16 GLRB CAMK4 CAMKK1 CAMKK2 KPNA2 PRKCG GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade RHO PDE6G CNGA1 GNB1 GNAT1 SLC24A1 SAG PDE6B CNGB1 GNGT1 PDE6A DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 EED H2BC3 H2BC1 H2AC20 GSDME RBBP4 EZH2 RBBP7 PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock FBXL3 CDK5 RORC RORA RORB SMARCD3 BTRC CARM1 PPP1CC NAMPT EP300 MED1 KMT2A RXRA SERPINE1 HDAC3 NR1D1 NRIP1 TBL1X BMAL1 NCOA1 ATF2 NCOR1 MEF2C TBL1XR1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PPARGC1A PSMA6 PSMA3 UBE2D1 NCOA2 PSMA4 PSMA1 NCOA6 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PPP1CA PSMD13 PSMA7 PSMB6 CRTC2 PSMB7 CRTC3 CRTC1 CSNK1D PSMB4 CPT1A PPP1CB SIK1 PSMB5 CSNK1E CLOCK NPAS2 UBB HELZ2 PSMB2 RAI1 PSMB3 CREBBP BHLHE40 UBC CHD9 BHLHE41 PSMB1 RBM4 DBP RPS27A TFEB KLF15 FBXW11 CRY2 CRY1 AVP CIPC ADRM1 CSNK2A1 FBXL21P NOCT TGS1 PSMC5 CSNK2A2 MEF2D PSMC6 SEM1 PER2 PSMC3 PER1 PSMC4 F7 PER3 PSMC1 CSNK2B PSMC2 BMAL2 SIRT1 SKP1 SREBF1 CUL1 PPARA REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity GJA1 TJP1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 PIK3R1 PIK3CA SRC IRS1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L KCNJ11 SLC5A1 ABCC8 SLC5A2 ABCC9 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 SLC67A1 RNF185 SLC26A3 APOA1 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 VCP SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC6A19 SLC27A4 SLC36A2 SLC6A14 SLC7A7 SLC7A9 GCKR GCK ABCA1 ABCG8 ABCG5 ABCA3 PSMD8 PSMD6 HK1 PSMD7 PSMD2 PSMD3 PSMD1 NUP214 SLC5A5 PSMA5 SLC35C1 PSMA6 CFTR PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 SLC24A1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SLC17A5 RPS27A SLC9A6 AVP ADRM1 SLC9A9 PSMC5 PSMC6 SEM1 SLC35A1 PSMC3 PSMC4 PSMC1 PSMC2 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes CREBBP ATF4 MAFK NFE2L2 EP300 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARL13B INPP5E PDE6D CCT2 CCT3 SMO TCP1 ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP HDAC6 BBIP1 RHO RAB11A ATAT1 TTC8 CNGB1 RAB8A SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CCND1 MAMLD1 RBPJ TNRC6C MOV10 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B ELANE E2F1 E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation BRD7 BRPF1 BRPF3 HDAC1 MTA2 PIN1 RBBP4 MBD3 MAP2K6 RBBP7 GATAD2B GATAD2A PML CHD3 ING5 PIP4K2A ING2 PIP4K2B PIP4P1 EP300 PIP4K2C AKT2 HDAC2 BRD1 KAT6A TP53 CHD4 MEAF6 AKT1 AKT3 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM NCBP1 NCBP2 FGF1 POLR2A FGF2 POLR2B FGFR2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB ZFP36 DCP1A EXOSC7 EXOSC6 EXOSC5 TNPO1 EXOSC4 DIS3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) PCNA YY1 RUVBL1 PARP1 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 RBX1 NFRKB CCNH ACTR5 RAD23A ACTR8 RAD23B CETN2 UBA52 INO80 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB UBB TFPT ACTL6A LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 DDB2 POLD1 RPS27A POLE POLD2 PIAS3 RFC2 RFC1 PARP2 USP45 LIG3 RPA1 RNF111 CHD1L DDB1 RPA2 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 COPS6 COPS5 MCRS1 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD NCAN CSPG4 CHST3 BGN DCN BCAN VCAN CSPG5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID BBC3 BCL2 BCL2L11 STAT3 PMAIP1 BCL2L1 BAD BMF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism ACSS3 BDH2 BDH1 HMGCL OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development YAP1 RBM14 HES1 BGLAP ABL1 RB1 MAF HDAC3 COL1A1 MAPK1 HDAC6 SP7 IHH UCMA MAPK3 GLI3 SMAD1 GLI2 SMAD4 HEY1 HEY2 SMAD6 HDAC4 SRC WWTR1 YES1 SATB2 CBFB ZNF521 AR OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency OTC HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs FKBP5 HSP90AA1 DYNLL1 DCTN6 DCTN5 ACTR1A HSP90AB1 DCTN1 DYNLL2 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 CAPZA3 DNAJA4 DNAJA2 CAPZA2 DYNC1I2 FKBP4 NR3C1 ACTR10 STIP1 HSPA1B CAPZB DYNC1LI1 DYNC1I1 DYNC1LI2 DCTN2 HSPA8 DYNC1H1 CAPZA1 DCTN3 HSPA1A PGR AR REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling IFNG JAK2 JAK1 SOCS3 PTPN6 PIAS1 PTPN1 SOCS1 SUMO1 IFNGR1 IFNGR2 PTPN11 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD CSPG4 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 B3GAT3 CSPG5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 YAP1 BGLAP ABL1 IHH NR3C1 ESRRA STAT1 MSX2 SMAD1 SMAD4 ESR1 BMP2 ZNF521 RBM14 RB1 MAF HDAC6 SKP2 CDK4 DLX5 DLX6 AKT2 SOX9 RUNX1 TWIST2 TWIST1 CBFB ITGA5 CDKN1A HDAC3 MAPK1 CCND1 SP7 MAPK3 NKX3-2 GLI3 GLI2 HAND2 PPM1D SMURF1 SMAD6 HDAC4 SRC SATB2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B AR PSMA5 STUB1 PPARGC1A PSMA6 PSMA3 PSMA4 PPARGC1B PSMA1 CCNB1 PSMA2 HES1 LGALS3 UBA52 PSMD12 PSMD11 CDK1 COL1A1 PSMD14 WWP1 BAX PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UCMA PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 HEY2 HIVEP3 ADRM1 WWTR1 YES1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 ITGBL1 PSMC2 SKP1 MMP13 CUL1 AKT3 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB IKBKB SQSTM1 UBC MYD88 RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR PRKCI UBB RIPK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 SKP2 CCNE2 KPNB1 PRIM2 CCNE1 PRIM1 POLA1 H2AX POLA2 LIG1 H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 KPNA6 POLRMT POLG2 RNASEH1 FEN1 MCM10 POLG TWNK DBF4 MGME1 EXOG RPA4 SSBP1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 TOP3A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation PCNA GINS1 GINS2 CDC45 GINS3 GINS4 PRIM2 PRIM1 POLA1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 MCM7 MCM8 RPA3 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RRAS FES PLXNA2 TLN1 PIP5K1C FARP2 PLXNA3 RAC1 FYN RND1 PLXNA4 NRP1 PLXNA1 SEMA3A ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization PERP PI3 CAPNS1 CAPN1 PKP1 DSP DSG1 DSG3 LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G DSG2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 FURIN PCSK6 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KRT12 KLK14 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 JUP KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PKP4 LELP1 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 CELA2A KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate DCXR AKR1A1 SORD CRYL1 XYLB IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AZ2 H4C9 PRMT6 PRMT5 SMARCB1 SMARCD1 PRMT1 SMARCD2 SMARCD3 H2AC20 H2AC1 H2AC25 H2AC21 CCND1 JAK2 SMARCC1 SMARCC2 PRMT7 PRMT3 CARM1 RBBP7 WDR77 COPRS CDK4 ARID2 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2AC14 RPS2 H3C8 H2AC8 H2AC6 H2AC7 SMARCA2 ACTL6B SMARCA4 H2AC17 H2AC12 H2AJ DNMT3A WDR5 ARID1A ARID1B H3C15 PBRM1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IPPK IPMK IP6K1 IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR10 MTMR2 MTMR12 PIK3C2A MTMR4 MTM1 PIK3R4 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3C3 VAC14 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation PTK6 PTPN1 SRMS EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis RASGRP2 RASGRP1 ITPR1 ITPR2 MGLL ITPR3 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 TRPC7 ABHD12 PRKCH TRPC6 DGKZ DGKQ PRKCQ TRPC3 PRKCE DAGLB DGKK DGKI DGKH PRKCD RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle RXRA MID1IP1 SLC22A5 SLC25A20 CPT1B PPARD PRKAB2 CPT1A PRKAA2 CPT2 PRKAG2 THRSP G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events TIAM1 GNG13 ARHGEF9 SOS1 OBSCN GNB2 ARHGEF3 ARHGEF4 GNB1 ARHGEF1 ARHGEF2 ARHGEF7 GNB4 SOS2 GNB3 RHOC ARHGEF5 NGEF GNB5 ARHGEF6 ARHGEF26 GNGT1 RHOA KALRN RHOB FGD1 FGD2 GNGT2 ROCK1 GNA13 ROCK2 FGD3 ABR FGD4 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 GNG3 GNG2 GNG5 GNG4 TBXA2R GNG7 GNG8 BTK GNA12 PLXNB1 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 GNG10 ADRA1D ARHGEF16 ARHGEF19 ADRA1B ARHGEF18 VAV1 ADRA1A VAV2 GNG12 TIAM2 GNG11 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID IKBKB NFKB2 RELA CHUK NFKB1 NFKBIA IKBKG SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 EHHADH ABCD1 DECR2 SLC27A2 ACOT4 ACAA1 ACOT8 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling DNMT1 SIN3A STAT3 PRDM1 EP300 CD274 HDAC1 IL2RG HIF1A HDAC2 HDAC3 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PIK3CB STRN SOS1 KDR FIP1L1 STAT3 PIK3R2 PIK3R1 NRAS PDGFRA HRAS WDR48 STAT1 PIK3CA KANK1 ETV6 GOLGA4 BIN2 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 MAP2K5 MAPK7 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid RXRA PPARD DHRS4 PDHB RXRG PDK3 DLAT RXRB PDK2 PDK1 PDHX PDHA2 PDHA1 RARG FABP5 CYP26A1 CYP26B1 CYP26C1 ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 PDK4 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 RARB ALDH8A1 RARA DLD ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) RXRA GGPS1 SCD CYP51A1 FASN LSS SREBF2 SQLE NCOA2 MTF1 DHCR7 NCOA6 SMARCD3 ACACB GPAM NFYA MVD NFYB NFYC TBL1X CARM1 NCOA1 HELZ2 CREBBP CHD9 SP1 TBL1XR1 ACACA MED1 TGS1 IDI1 MVK ELOVL6 TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling NEDD4L STUB1 PMEPA1 BAMBI STRAP UBA52 TGFB1 TGFBR1 TGFBR2 PPP1CA USP15 PPP1R15A PPP1CB PPP1CC UBB UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD3 SMURF2 SMAD7 SMURF1 XPO1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism ARSB GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 GBA1 NEU2 ENPP7 NEU3 ARSA SUMF2 SUMF1 NEU1 ASAH1 ASAH2 ARSL ARSJ ARSK PSAP ARSH ARSI CTSA ARSF HEXB ARSG HEXA ARSD GLB1L3 M6PR GLB1L2 GALC GLA GLB1L GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 EGF HES1 EGFR WWC1 NEURL1B UBA52 DLGAP5 HES5 PLXND1 APH1A PTCRA DLL4 MIB2 PSENEN PBX1 NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 TACC3 MAMLD1 PSEN1 STAT1 UBB RBPJ CREBBP UBC MAML2 FABP7 MAML1 RPS27A YBX1 HEY1 KAT2B KAT2A EP300 JAG2 SNW1 HEY2 JAG1 DLL1 MAML3 NOTCH3 NOTCH1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS AP2A1 AP2A2 FURIN SAP30L AP2M1 ATP1B3 ATP1B2 ROCK1 ATP1B1 ROCK2 CUL3 IGHV3-23 ARID4A IGLV MBD3 COMT IGLV2-8 NR3C1 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 GATAD2B IGHV3-30 RIPK1 GATAD2A IL1R1 SUDS3 IGHV3-33 AP2S1 IGKV1D-39 ZBP1 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 FXYD4 PHF21A FXYD3 CD79B IGLV2-11 FXYD2 CD79A IGLV1-40 FXYD1 IGLV1-47 IGLV6-57 FXYD7 IGLV2-14 FXYD6 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CHD4 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV SAP18 IGKV2-29 IGKV2-28 IGLC3 ATP1A4 BLNK ATP1A3 HMG20B MTA2 IGLC1 ATP1A2 FNTB IGLC2 S1PR1 JAK3 ATP1A1 SIGMAR1 RBBP4 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 REST IGLV3-19 MTA3 IGHV2-70 RBBP7 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FNTA BRD4 CRBN IGLC7 IGHV3-53 IGKV5-2 NCK1 STAT2 IGLC6 IL6R IGKV1-5 IMPDH1 IMPDH2 PDCD1 ITGB1 VAV1 TLR9 SOS1 HDAC1 HSP90AB1 KDM1A PTGES3 FKBP4 IFNGR1 IFNGR2 ITGA4 CHD3 HDAC2 FKBP1A KEAP1 RBX1 BTK JAK2 TUBB ARID4B JAK1 SAP30 TYK2 NFE2L2 SYK SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling RRAS PLXNB1 ERBB2 RHOC ARHGAP35 SEMA4D RHOA LIMK2 RHOB LIMK1 RAC1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MET MYH10 MYL9 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 FKBP5 HTT HDAC1 GAD1 SGK1 GAD2 HDAC3 GPS2 SIN3A PRKACA MET TBL1X DGCR8 PTPN1 AURKB NCOR2 TNRC6C GPRIN1 MOV10 NCOR1 MEF2C TBL1XR1 AGO3 IRAK1 AGO4 RBFOX1 CAMK2B GRIA2 AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A GRIN2B PTEN SLC2A3 GRIN2A TRPC3 OPRM1 SST CALM1 CAMK2G PTPN4 CRH OPRK1 LBR HIPK2 PVALB FOXG1 SOX2 MOBP GAMT DLL1 CAMK4 BDNF PPARG CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation MIB2 ITCH HSPA5 SAR1B TLR1 S100A9 S100A8 TLR2 STX4 UBE2L3 CD14 BTRC TLR4 LY96 RNF111 UBE2V2 LRR1 HMGB1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SEC31A SOCS1 HACE1 SIAH1 LNPEP MEX3C IKBKB UBAC1 FBXL8 MYD88 CD207 CALR CANX FBXL4 DZIP3 RNF220 DET1 LRSAM1 CTSS MRC2 TRIM9 MRC1 ARIH2 LRRC41 VAMP8 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 TLR6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 PSMB8 PSMB9 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 NCF1 KLHL5 PSMA5 RLIM NCF2 PSMA6 TRIP12 NCF4 PSMA3 KBTBD7 SNAP23 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 BTK RNF19B UBE3A PSMD12 SEC61G UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 SEC61B NPEPPS PSMD13 RNF19A PSMA7 PDIA3 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 S100A1 UBE2E3 CYBB TRIM4 PSMB4 FBXO17 TAP2 CYBA PSMB5 FBXO15 IKBKG UBE2E2 TAP1 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 VAMP3 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 PSME2 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 CUL3 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 RBBP6 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 SMURF2 ASB13 B2M ASB14 ASB11 RNF6 ASB12 HLA-A RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 SEC13 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 BECN1 SEC24D ASB2 ASB3 SEC24C SKP2 ASB1 CDC20 SOCS3 PIK3C3 ITGAV SH3RF1 ITGB5 PIK3R4 FBXO32 CHUK MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 CD36 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FGB FGA FGG FBXW11 FBXL21P SEM1 SKP1 CTSV CTSL CUL1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis ENO1 TRIM27 KPNA1 UBA52 ATP6V1H MAPK1 CTSG DUSP16 VPS33B CORO1A PGK1 HGS RNF213 RAB5A KPNB1 MAPK3 UBB UBC RPS27A RAB7A B2M SFPQ MRC1 NOS2 LTF TLR2 GSK3A INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA AREG EGF EGFR EREG BTC EPGN SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF23 FGF4 FGFR1 FGF6 FGF9 FGF20 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events FURIN RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX ACE2 MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 ANO8 CSNK1A1 PARP14 ANO9 PARP8 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 UBA52 ST6GALNAC3 ST6GALNAC4 TMPRSS2 SRPK2 ANO10 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors CALCRL ADM2 ADM IAPP RAMP1 RAMP2 CALCA RAMP3 CALCB CALCR DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC TCN2 CD320 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle FURIN CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TBP NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 RANGAP1 TAF7L ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A F9 F10 TPST2 TPST1 F8 F2 VWF NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COL4A2 COL4A1 FTH1 SCGB3A2 MASP1 CALR FTL COL1A1 APOA1 COL1A2 APOB APOE COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus BANF1 XRCC6 XRCC4 KPNA1 XRCC5 LIG4 PSIP1 PPIA HMGA1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MKRN1 CDKN1A AKT2 TSC2 MDM2 CDKN1B CHUK AKT1S1 GSK3A AKT1 CASP9 BAD GSK3B AKT3 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones H2BC9 H4C9 H2BC8 H2BC5 H2BC3 SAP30L H2BC1 HDAC1 H2AC20 H2AC1 HDAC3 KDM1A GPS2 ARID4A MBD3 TBL1X GATAD2B GATAD2A SUDS3 NCOR2 CHD3 BRMS1 NCOR1 TBL1XR1 HDAC2 PHF21A H2AC17 H2AC12 CHD4 RCOR1 H2BC18 SAP18 HMG20B HDAC8 MTA2 H2AC25 H2AC21 RBBP4 MTA1 REST ARID4B MTA3 RBBP7 SAP30 H2AC19 H2BC26 H2AC14 H2BC21 HDAC10 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 EGFR CDC37 NRAS PLCG1 NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification SEL1L RPN2 ERLIN1 TUSC3 PDCD1LG2 ERLIN2 B3GNT3 RPN1 SPOP MAGT1 MIB2 RNF185 CCND1 CUL3 VCP OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 DERL3 DERL1 OSTC DERL2 RNF5 ERLEC1 STT3A OS9 STT3B PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B YWHAG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PDCD1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 COPS5 CUL1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN CSPG4 BGN DCN BCAN VCAN CHST14 CSPG5 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function OPN1SW E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 H2BC3 PEX14 H2BC1 HLA-B RNF20 VCP UBE2J2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC UBA52 PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PEX2 UBB UBC RPS27A UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2B UBE2N PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 CRY2 CRY1 CSNK2A1 CSNK2A2 PER2 PPP1CA PER1 PER3 CSNK2B CSNK1D PPP1CB CSNK1E PPP1CC HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT SHH IHH DHH TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling CDC42 DCC NTN1 TRIO NCK1 SRC RAC1 ABLIM1 WASL ABLIM2 PTK2 ABLIM3 DOCK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 HSPG2 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L CD209 SDC4 SDC2 SDC3 CDK8 AGRN TLR3 IRF3 GPC1 IFNAR1 GPC3 MAVS GPC2 GPC5 GPC4 GPC6 RIGI TLR6 ELOB TLR2 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 CD14 BECN1 TLR7 IFIH1 JAK1 TLR4 UBB MED16 BCAP31 MED15 MED17 CREBBP UBC MED12 TYK2 MED14 MED13 RPS27A MED10 STAT2 EP300 CUL5 LY96 MED1 MED30 MED31 MED8 MED4 MED27 MED6 MED26 MED7 H2BC15 MED23 UBE2L6 MED25 IFNA5 HERC5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 HSPD1 TFAP2A NPM1 MYBL2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 APEH RPL7A RPL18A HEMK2 RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 TRMT112 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 CHAC1 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux RXRA CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB APOD APOE TBL1X NCOA1 ABCA1 ABCG8 KDM4A ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 EP300 APOC2 APOC1 AGO1 AGO2 TNRC6A ABCG1 TNRC6B NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors NKX2-5 KAT2B WWTR1 HIPK1 HIPK2 MME NPR1 NPR2 TBX5 NPPC CORIN CES1 GATA4 NPPA CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic PCNA YWHAE EML4 CDCA5 MYBL2 NCAPG YWHAG ARPP19 NCAPH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 CHMP3 CHMP6 CHMP7 CDC7 FBXL18 FBXL7 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH LYN CDKN2B CDK7 MNAT1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 ABL1 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 JAK2 PPP1CB HJURP RFC5 PPP2R2A RFC3 PPME1 GTSE1 RFC4 BORA FKBPL RFC2 FBXW11 OPTN OBI1 HMMR RPA1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B TICRR MCM7 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MYC PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 HAUS8 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 KMT5A HSP90AA1 CDC25C CDKN1C RB1 CDKN1B CCND3 FZR1 CCND2 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX CPAP LIG1 MAX H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 RCC1 H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 GSK3B PHLDA1 AKT3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation UPK1A EPCAM METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids ACSS3 MED19 SLC22A5 ABCB4 MED18 MED11 AGPAT2 SLCO1B1 SLCO1B3 MED9 MED29 MED28 MED22 MED21 THRSP GPAM GAL3ST1 CERK GBA3 CDK19 GBA2 SMPD3 SMPD2 STS SMPD4 MED13L GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLA2G4A SUMF1 B3GNT5 GGT5 B4GALT6 B4GALT5 ASAH1 ASAH2 ABCB11 FUT2 FUT1 UGCG UGT8 ARSL ARSJ GGT1 ARSK VDR PSAP ARSH ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC CYP2C9 NDUFAB1 CYP2C8 CYP2U1 CYP4F2 CARM1 CYP1A2 RAB5A KPNB1 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PIP4K2A NSDHL PIP4K2B LIPI PIP4K2C CYP2D6 LIPH FDXR SULT2A1 MED1 STARD3 BMX ACOT9 STARD4 STARD5 ACOT7 MED8 MECR STARD6 MED4 STARD7 MED6 MED7 RUFY1 CH25H PRKD3 FDX1 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 TIAM2 CYP2E1 FAR2 MTMR3 MTMR8 CGA BDH2 PLA2G3 BDH1 MTMR9 OXCT1 PLA2G5 OXCT2 PLA2G6 HMGCS2 MTMR6 HMGCLL1 MTMR7 AACS HSD11B1 ACAT1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA PTGES3 CYP4F3 NR1D1 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE CYP27B1 TSPO SPHK2 PTGR1 CYP24A1 PTGR2 CYP21A2 CYP2R1 AHRR SAMD8 PIP4P1 ECHS1 SGMS1 SGMS2 UBE2I PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIP5K1C PIAS4 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 INPP5D ABHD4 PIK3CG ABHD3 PIK3R6 INSIG2 PIK3R5 INSIG1 ARF1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 GBA1 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 CSNK2A1 PLA2G12A CERS5 GPX1 CSNK2A2 CERS6 GPX4 FAAH2 TNFRSF21 CERS1 CSNK2B CERS2 PPM1L HSD17B14 TPTE LRP2 CYP3A4 HSD17B11 MMAA MMUT AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 MBOAT1 DDHD2 MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PCCA PITPNB CPNE7 ECI1 PCCB CPNE6 GDE1 ACACB ACSM6 CPNE1 CPNE3 PTGDS MFSD2B ACAD11 SPHK1 ACAD10 MFSD2A SACM1L SLC51A ESRRA SLC51B PISD CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 CDK8 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 MTMR1 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPX2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS CBR1 SMARCD3 PCYT1B PCYT1A STARD3NL PLAAT1 PLAAT3 PLAAT2 CYP7B1 PLAAT5 PLAAT4 AKR1D1 GDPD1 ALOX12B GDPD3 GDPD5 HSD17B7 CYP7A1 ORMDL2 PPP1CC HSD17B1 TXNRD1 ORMDL3 HSD17B2 PIK3CB SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CYP8B1 ETNPPL PLEKHA8 PNPLA3 PTPN13 PNPLA6 VAPB ACAA2 INPPL1 MSMO1 CYP46A1 PLB1 ENPP6 PIK3CA PIK3R3 SBF1 HADH SBF2 PIK3C3 TPTE2 TRIB3 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 THEM4 CHAT PLD4 PLD6 ARNT2 PLD3 NFYA ALDH3B2 NFYB EBP NFYC CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 BMAL1 ACBD6 ACBD4 DGAT2L6 CRLS1 ACSF2 CYP11B2 PI4KA VAC14 PI4K2B PLD2 DEGS1 MTMR10 ALPI MTMR2 DEGS2 MTMR12 PI4KB PIK3C2A ACBD5 TNFAIP8 MTMR4 CYP4A22 MTM1 DBI INPP4A PCTP FIG4 ACOXL INPP4B ABCC3 PLA2G4F PIKFYVE INPP5F ABCC1 PI4K2A PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L ME1 CPT2 POMC MID1IP1 SLC25A20 PPP1CA CPT1B CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT PPP1CB CYP11B1 AKR1C3 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 LDLRAP1 CUBN APOA2 APOA1 PRKACG APOA5 PRKACA PRKACB ANGPTL4 SAR1B MBTPS1 ALB MBTPS2 PLA2G2A SLC27A1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 PRKAA2 PHYH ACOT8 PRKAG2 GNPAT ACOT2 ACOT4 PRKAB2 HACL1 DECR2 HAO2 EPHX2 PPARGC1A AMACR PPARGC1B RAN MAPKAPK2 CROT LBR ABCD1 OCRL BAAT MED16 SLC25A17 MED15 ACOX2 MED17 MED12 EHHADH MED14 MED13 AGPS ACOX3 MED10 TAFAZZIN HSD17B4 MED27 HMGCL MED26 MED23 MED25 MED24 MED20 PPARG CAV1 PPARA SRD5A3 PPARD NUDT7 VAPA CRAT SEC23A HEXB HEXA LTC4S RORA GLB1L3 GLB1L2 GLB1L SEC24B GLB1 SEC24A PLD1 ARSB HADHB HADHA ACADVL CYP17A1 SEC24D SEC24C EP300 MED30 MED31 RXRA INPP5E HDAC3 MOGAT3 MOGAT2 MOGAT1 GPS2 ABHD5 FABP12 RXRB GK3 GK2 LIPE AGMO GPAT2 TBL1X DGAT2 GK NCOA1 ABCA1 DGAT1 FABP9 FABP1 FABP2 FABP3 NR1H2 FABP4 FABP5 NR1H3 GPD2 NCOR2 FABP7 ARNT PNPLA4 PLIN3 NCOR1 PNPLA5 TBL1XR1 LPIN1 FABP6 LPIN2 MGLL SUMO2 LPIN3 PLIN1 PEX11A CD36 NCOA2 NCOA6 NCOA3 CCNC MVD PLIN2 ST6GALNAC5 ST6GALNAC6 PNPLA2 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 CREBBP SP1 NEU1 CHD9 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA TGS1 SREBF1 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGF ERBB2 MEMO1 EGFR RHOA NRG1 DIAPH1 EREG NRG3 NRG4 NRG2 BTC REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins JUP PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 SOX10 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 CDH19 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 SV2C SV2B SV2A VAMP1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 PRKAB2 PRKAA2 ADIPOQ MLXIPL PRKAG2 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression ASAH1 DICER1 TRPM1 PXN SMARCD1 SMARCD2 SMARCD3 SMARCE1 LIG1 GMPR SOX2 AKT2 ATP6V1E1 ATP6V1G1 ATP6V0B ATP6V0E1 DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H TBX2 HINT1 CCND1 ITGA2 SIN3A CDK2 CTNNB1 MET ATP6V1C1 GPR143 TNRC6C MOV10 TFAP2A AGO3 STT3B AGO4 CDH1 AGO1 AGO2 DPF1 TNRC6A TNRC6B DPF2 DPF3 SS18L1 ARID1A ARID1B PPARGC1A PLK1 SS18 SMARCB1 CCNB1 SOX10 SMARCC1 BRCA1 SMARCC2 ACTB ACTL6A GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CCND1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 GSK3B RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 TRMT10C FASTKD2 PRORP MTERF4 ELAC2 TFB1M MRM1 HSD17B10 MRM2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing NFKB2 CTSG RELA IL18 IL1A CASP1 NFKB1 IL1B GSDMD PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B PIWIL2 POLR2C TDRKH POLR2D HSP90AA1 PIWIL1 POLR2E HENMT1 POLR2F ASZ1 POLR2G MAEL POLR2H MOV10L1 POLR2I POLR2J MYBL1 POLR2K TDRD9 POLR2L TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 PIWIL4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation HDAC6 HSBP1 PTGES3 EEF1A1 HSF1 YWHAE RPA3 HSP90AA1 VCP RPA1 HSP90AB1 RPA2 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 OGG1 NEIL1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 CTNNB1 AXIN2 TCF7L2 TCF7L1 MYC LEF1 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle FURIN CCR5 CXCR4 CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 TBP NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 HMGA1 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 LIG1 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 XRCC6 CHMP7 XRCC4 XRCC5 LIG4 RANGAP1 TAF7L FEN1 ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events KNG1 RASGRP2 RASGRP1 NPFFR2 OXTR NPFFR1 RGSL1 GRPR AVPR1B CYSLTR1 EDNRA EDNRB PROK2 PROK1 AVPR1A UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT NTSR1 NTSR2 ITPR1 GPR17 ITPR2 NMB ITPR3 XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN TRPC7 BRS3 GPRC6A GPR132 TRPC6 CCKAR GNRHR TRPC3 FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R MCHR1 P2RY10 P2RY11 LPAR1 GCGR LPAR2 GPR4 LPAR3 GCG LPAR5 MT-RNR2 F2RL1 F2RL2 CHRM3 F2RL3 CHRM1 GPR68 GPR65 CHRM5 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 TRIO MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 PRKCQ PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 RGS16 ADRA1D P2RY6 HTR2A P2RY2 ADRA1B P2RY1 RGS21 ADRA1A CCK HRH1 HCRTR2 HCRTR1 KISS1 HBEGF MAPK7 KALRN GPR143 PTGFR PTGER1 TBXA2R AGT PRKCD PRKCA BTK GRK2 PRKCE GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 FFAR1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARHGEF25 EGFR HRAS PIK3R3 PIK3CA SOS1 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 MGLL DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ DAGLB DGKK DGKI DGKH AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL1A1 COL25A1 COL1A2 COL22A1 COL23A1 COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL20A1 COL4A6 COL6A3 COL21A1 COL9A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COL3A1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 DCP2 MAPK11 PARN EXOSC7 KHSRP EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 FGF20 FGF16 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions OCLN RUNX1 TJP1 CBFB CLDN5 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex PCNA UBA52 WDR48 RAD18 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2B POLE2 POLE3 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACSM6 ECHS1 ACSM3 ACADS HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) STPG4 UHRF1 H2BC9 METTL23 H2AZ2 H4C9 DPPA3 H2BC8 H2BC5 H2BC3 H2BC1 AICDA H2AC20 TET3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KDM5B H2BC12 KDM5A H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 KDM6B H3C15 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6C MOV10 AGO3 AGO4 CD274 AGO1 AGO2 TNRC6A TNRC6B RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G POLR3H POLR2K POLR3K POLR2L POLR1C POLR1D MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation MET HGF SPINT1 HPN SPINT2 HGFAC PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade PIK3R4 PIK3R2 PIK3R1 FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis PARP1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum POFUT1 NOTCH2 NOTCH3 NOTCH1 POGLUT1 NOTCH4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events AKT2 PDE3B POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels GNG13 GNB2 KCNJ8 GNB1 KCNJ11 ABCC8 ABCC9 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNMA1 GNG3 GNG2 GNG5 GNG4 GNG7 KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK1 KCNN2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ2 KCNJ2 KCNQ3 KCNJ3 KCNQ4 KCNJ4 KCNQ5 KCNV1 KCNV2 GABBR2 KCNN1 KCNJ5 KCNN3 KCNN4 KCNJ6 KCNF1 GABBR1 KCNC1 KCNJ10 KCNK9 KCNC2 KCNJ12 KCNC3 KCNJ9 KCNC4 KCND1 KCND2 KCND3 KCNJ15 KCNAB1 KCNJ16 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 KCNK4 HCN1 GNG10 GNG12 GNG11 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction SORBS3 MYL5 MYL7 ITGA1 PXN ITGB5 GUCY1B2 GUCY1B1 TPM4 TPM3 GUCY1A2 GUCY1A1 PDE5A ANXA2 TLN1 VCL TRIM72 DYSF PAK1 LMOD1 MYL6B MYL12B CACNA1H MYL6 MYL12A MYLK CACNA1G MYH11 CACNA1I MYL9 ALDH2 CALD1 PAK2 ANXA6 MYL10 CAV3 TPM2 MYL11 CALM1 TPM1 ANXA1 SORBS1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C OXA1L KGD4 UCP1 NDUFAB1 ACAT1 MT-CO1 BCS1L COX19 COX17 ATP5MC1 SCO2 MT-CO2 MT-CO3 CYC1 CS VDAC1 ACO2 UBA52 HSCB HSPA9 TIMM21 UBB UBC RPS27A SLC25A12 FXN SLC25A13 NDUFB8 ATP5F1A SIRT3 ATP5F1B IDH3G CYCS MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 PC CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D LETM1 MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SLC25A4 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ATP5MK COX11 ATP5MJ COX14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5MF ATP5ME COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 COXFA4 NDUFA6 FAHD1 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 PDK4 NDUFS3 WDR26 PDHB GOT2 RMND5B LDHA MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 ECSIT PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 COX7B GPT COX7C COX8A COX8C DLD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A IK SNRPN PRP4K WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response XIAP CARD8 CYCS UACA MAPK1 AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells FGF10 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K4 IKBKB UBC RPS27A FBXW11 NFKB1 TNIP2 UBA52 BTRC CHUK SKP1 MAP2K1 MAP3K8 IKBKG CUL1 UBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins MUC13 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 MUC1 POMT2 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 POMT1 MUC4 MUC6 POMGNT1 MUC16 GALNT3 B4GAT1 MUC17 C1GALT1 MUC19 DAG1 SSPOP MUC5B LARGE1 MUC20 MUC21 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 SH3GL1 UBA52 STAM STAM2 MET HGS UBB SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 DPH7 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEL1L RAD23B PRKCSH UBA52 RNF185 GANAB PDIA3 VCP EDEM2 MOGS UBB DERL1 UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 UBXN1 PSMC1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects PNP PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway CLTC CLTB FZD2 WNT5B FZD5 FZD7 WNT5A ROR1 FZD4 CLTA ROR2 AP2A1 PRICKLE1 FZD6 RAC2 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 RHOA AP2S1 SMURF2 SMURF1 AP2B1 PSMD8 PSMD6 PSMD7 PSMD2 ARRB2 PSMD3 SCRIB VANGL2 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DAAM1 PFN1 PARD6A ADRM1 PSMC5 PSMC6 RAC1 PRKCB SEM1 PSMC3 DVL1 PSMC4 DVL2 WNT4 PSMC1 DVL3 PSMC2 PRKCG WNT11 FZD3 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOT2 ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B KIF5A NCKIPSD RAP1GDS1 KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 VHL AR CFTR RHOT1 BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 LRRC41 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 CCNE1 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 PLIN3 NCOA2 PTK2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT5 GGT7 GGT6 DPEP2 GGT3P DPEP1 GGT1 ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CYP3A4 CYP1A2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R3B E2F1 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B POLA2 PPP2R1A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin F8 F2 VWF INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 ISL1 GIP DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C GATA4 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO SAE1 SENP5 SUMO3 SENP1 SUMO2 SENP2 UBE2I SUMO1 RWDD3 UBA2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HNRNPC BMI1 SUMO2 RING1 HNRNPK UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 NOP58 CBX2 PHC3 AAAS NUP160 NUP214 POM121C NUP42 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 KLB FGF16 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 ECHS1 ACAT1 MCCC1 PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A CSK RAF1 JAK2 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 IGF2 CTSG IGF1 TF CALU KLK3 KLK2 SERPINA1 MBTPS1 KLK13 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN PLG ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 LAMB2 PDIA6 PAPPA MXRA8 SPARCL1 FN1 IGFALS LAMB1 SCG2 KLK1 LAMC1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 GZMH NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC F2 GAS6 APLP2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling IFNA2 IFNA8 TYK2 IFNA13 IFNA14 IFNA16 STAT2 IFNA17 SOCS3 PTPN6 IFNAR1 IFNA10 IFNA21 IFNB1 JAK1 IFNA5 IFNA4 PTPN1 SOCS1 IFNA7 USP18 IFNA6 PTPN11 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CB RAPGEF1 CRK PIK3CD LYN PIK3R2 CBL PIK3R1 YES1 HCK BLNK SYK FYN PIK3R3 CRKL PIK3CA VAV1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling DPYSL3 FES PLXNA2 PLXNA3 CDK5 FYN PLXNA4 NRP1 CDK5R1 CRMP1 GSK3B DPYSL4 PLXNA1 DPYSL5 SEMA3A DPYSL2 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade SOS1 SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS FGF20 THEM4 MAPK1 FGF23 FGF22 KLB MAPK3 FLT3 IRS1 INSR PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade SERPING1 C3 CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PROS1 F2 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PFKFB1 PRKACA PRKACB MLXIPL ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells UPK1A EPCAM FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation FGF23 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism PNPLA7 PNPLA6 GDPD1 GDPD3 GDPD5 ENPP6 GDE1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3CA PIK3R3 PIK3R5 ICOSLG FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription CITED2 GCK FBXO32 G6PC1 CDKN1A INS HDAC1 NPY NFYA CCNG2 SIN3A NFYB NFYC BCL2L11 PLXNA4 FASLG PCK1 NR3C1 FOXO4 ATXN3 BTG1 DDIT3 TRIM63 STK11 SMAD2 SMAD4 AGRP SMAD3 BCL6 HDAC2 YWHAB TXNIP PINK1 AKT1 YWHAQ YWHAG RBL2 YWHAZ SFN PPARGC1A CAT ABCA6 RETN CDKN1B POMC SOD2 KLF4 CREBBP BBC3 FOXG1 KAT2B FOXO6 PCBP4 FOXO1 EP300 AKT2 IGFBP1 SIRT1 MSTN SIRT3 FOXO3 TXN SREBF1 GADD45A CAV1 AKT3 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex BICRAL ACTL6A BICRA BRD9 SS18 SMARCD1 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SS18L1 ACTB TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation SNAP25 RAB3A SLC32A1 STX1A SYT1 SLC6A13 HSPA8 ABAT SLC6A1 VAMP2 CPLX1 GAD1 RIMS1 GAD2 ALDH5A1 DNAJC5 SLC6A11 SLC6A12 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase OCLN DSG1 DSG3 PLEC ADD1 ROCK1 H1-1 H1-0 H1-3 LMNB1 CTNNB1 TJP1 H1-2 H1-5 H1-4 VIM CLSPN CDH1 SATB1 CASP6 PRKCD APC KPNA1 BIRC2 SPTAN1 DFFB DFFA DBNL ACIN1 KPNB1 GAS2 MAPT BCAP31 GSN TJP2 FNTA DSG2 PKP1 BMX STK24 STK26 HMGB2 HMGB1 PRKCQ CASP8 PAK2 PTK2 CASP7 DNM1L DSP CASP3 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants ALK DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair NEIL3 NEIL1 PMS2 MLH1 MSH2 MSH3 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 MSH6 RMI2 RFC3 RFC4 RMI1 OGG1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A NTHL1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling RELA MAP3K7 IL1RL1 IL33 CTSG MAP2K6 IL1RL2 IL36A IL36B IL1R1 IL36G IL36RN IL1F10 SMAD3 TBK1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 GSDMD USP14 BTRC IL18 NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 PTPN13 HMGB1 CASP8 MAP2K1 UBE2N STAT3 NFKB1 MAPK8 CHUK PTPN11 IKBKB SQSTM1 MYD88 SIGIRR IRAK3 ALOX5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 CASP1 PSMD1 PSMA5 PSMA6 PSMA3 PTPN4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL18RAP IL1R2 PSMD13 IL4 NFKB2 TOLLIP PSMA7 PTPN20 PTPN23 PSMB6 IL18BP IL13 PSMB7 IL1RAPL1 PSMB4 MAP3K3 NKIRAS1 PTPN18 NKIRAS2 PSMB5 IL37 MAP3K8 IKBKG PTPN12 UBB PTPN14 IKBIP RIPK2 PSMB2 PTPN9 MAP2K4 PSMB3 PTPN7 IRAK4 PTPN5 UBC IL18R1 PSMB1 PTPN2 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 PTPN6 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 ELAC2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG ABHD6 ABHD12 DAGLB MGLL DAGLA MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR3 CTSS CNPY3 TLR8 TLR7 CTSB CTSV CTSL LGMN CTSK HSP90B1 TLR9 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 HBS1L EXOSC7 NT5C3B EXOSC6 SKIC2 SKIC3 DCPS EXOSC5 EXOSC4 DIS3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 VCP SHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA PARP1 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 RFC2 RFC1 PARP2 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 PARG APEX1 ADPRS PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria PAH NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways NUP85 TPR KPNA7 NUP62 KPNA4 KPNA5 NUP88 GBP1 NUP43 KPNA3 RAE1 PABPN1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 EIF2AK2 ISG15 NUP37 KPNB1 MLKL KPNA2 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 GP1BA H2AC20 SETD1B SETD1A SIN3A ASH2L TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B NR4A3 MYL9 SIN3B DPY30 WDR5 GATA1 THBS1 RBBP5 PF4 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KAT2B KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 ZFPM1 PRKCQ H2BC11 KMT2A CBFB ITGA2B H3C15 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA CYP26B1 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation AGPAT2 ARPC5 GM2A ACTR2 APEH ARSA FGR ASAH1 PECAM1 RAB9B PSAP MGST1 MME GLA P2RX1 CAT IST1 CD14 GSDMD RETN SPTAN1 DBNL FUCA2 KPNB1 GSN TICAM2 DNAJC3 PKP1 SDCBP RAC1 CST3 HMGB1 DSP DSG1 C3AR1 MAGT1 LTA4H NCSTN ADAM10 PSEN1 CDK13 GOLGA7 C5AR1 ACTR10 HSPA1B DDOST LPCAT1 ALOX5 CD59 CD55 HPSE SNAP25 RAB3A DNAJC5 KRT1 CNN2 TOLLIP ANXA2 MIF PPIA CSNK2B CTSB CDA FRMPD3 RAB14 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 RNASE2 UNC13D FLG2 PADI2 FPR1 CPNE1 GNS CPNE3 PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 VCP FUCA1 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 HMOX2 SIGLEC5 GHDC TMEM179B RAB3D HP EPX SLC44A2 PYCARD RAB44 CR1 GLIPR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B RAB5C STK10 BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 FCAR ALAD FCGR3B ORMDL3 PGM2 ACP3 TCIRG1 SNAP29 PGM1 RNASET2 DYNC1LI1 TNFRSF1B PKM PTGES2 TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC CTSD TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 FAF2 PTPRN2 SIGLEC14 ATP6V0C STK11IP SURF4 PRG2 NBEAL2 PRG3 RHOG DYNLL1 DERA BST2 RHOF BST1 NRAS VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ MAPK1 ACTR1B CTSH CD33 CTSC CD53 ATP6V1D MANBA ALDH3B1 FCER1G GAA NME2 ATP6V0A1 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CD47 DEGS1 CD44 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 CKAP4 OSTF1 CD93 LRRC7 CD300A IRAG2 ATAD3B OSCAR TYROBP DOCK2 DOK3 COPB1 ADGRG3 MOSPD2 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 NAPRT ADGRE3 HGSNAT DYNLT1 ATP6AP2 ARMC8 PLAUR MMP8 MMP9 CHI3L1 PDXK BIN2 CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 RAB27A CEACAM1 LAMP2 PPIE ARG1 AP2A2 A1BG SLC15A4 RAP1B RAP1A CTSG NPC2 PPBP PRSS3 PGLYRP1 PRSS2 CAMP SERPINA3 ORM1 FPR2 SLC11A1 SERPINA1 RNASE3 ORM2 TRPM2 BPI QSOX1 PRTN3 S100A9 CAP1 S100A8 AHSG LTF TLR2 S100A7 CD63 PTAFR DEFA1B ELANE DEFA4 LYZ CAPN1 LCN2 AMPD3 APRT PNP IMPDH1 IMPDH2 EEF1A1 ACLY HLA-H SLC27A2 HLA-B HLA-C HSP90AB1 ACAA1 ATG7 CAB39 B4GALT1 CTSS VAMP8 PSMD6 PSMD7 HUWE1 PSMD2 PSMD3 LAMTOR2 LAMTOR1 PSMD1 LAMTOR3 CYFIP1 IDH1 PRKCD PSMA5 SNAP23 PSMA2 PSMD12 PSMD11 STBD1 PSMD14 CEP290 PSMD13 KCNAB2 TUBB PSMB7 CYBB CYBA PSMB1 RAB7A HSPA8 MAPK14 UBR4 PSMC3 PSMC2 HSPA1A NCKAP1L APAF1 CFD C3 ATP8A1 VAPA ATP11B CCT2 ATP11A ROCK1 ATP8B4 B2M STING1 AP1M1 HEXB GLB1 ARHGAP45 IQGAP1 ANO6 PLD1 GUSB IQGAP2 ARSB HSP90AA1 FRK JUP ARHGAP9 STOM ITGAV FTH1 FTL NDUFC2 XRCC6 XRCC5 NFKB1 ITGAX CHRNB4 ITGAL DGAT1 FABP5 GPI CD36 HK3 PGAM1 LGALS3 CFP ALDOC ALDOA PFKL NEU1 PTPN6 CTSA S100A12 EEF2 MLEC TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP PML UBC PTEN RPS27A NEDD4 USP7 UBA52 UBB MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins MET TNS4 TNS3 HGF ITGB1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling HBEGF EGF ERBB2 PIK3R1 EGFR NRG1 GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion PDS5B SMC1A SMC3 PDS5A WAPL STAG1 STAG2 ESCO1 RAD21 ESCO2 CDCA5 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation UGT2B7 UGT1A3 SLC35D1 SLC35D2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT1A9 UGT2B17 UGDH UGT2B4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CX3CR1 CCL3L3 CXCR5 CCR5 CXCR6 CXCR4 CCL7 CCR6 CCL5 CXCR3 PPBP CCL4 CCL3 CCL2 CCL1 CCL19 CCR2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 CXCL10 CXCR1 CXCL11 CXCL12 CXCR2 ACKR4 ACKR3 ACKR2 XCR1 CCL28 CCL27 CXCL1 PF4 XCL2 XCL1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism SERINC4 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 LBP CD14 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse LYN NGEF YES1 RHOA ROCK1 MYL12B FYN ROCK2 MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2S1 AP2A1 AP1G1 AP1S2 AP1S1 AP2A2 AP1S3 B2M AP1M2 AP2B1 AP1M1 AP1B1 HLA-A AP2M1 ARF1 CD8B PACS1 ATP6V1H LCK CD28 CD4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events NTRK1 KIDINS220 RAPGEF1 CRK NGF YWHAB MAPK1 RAP1A FRS2 MAP2K1 MAP2K2 CRKL MAPK3 BRAF NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR FLT1 NRP2 KDR NRP1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer PRF1 ICOS STAT5A IL10RA ZC3HC1 STAT3 CCNB1 HDAC1 NPM1 GZMB RB1 MAPK1 CEBPB MAPK3 DNMT1 FOXM1 TNRC6C MOV10 AGO3 AGO4 JUNB PTPN6 AGO1 AGO2 RPS6 IRF4 BCL2A1 SKP1 RBX1 TWIST1 ZAP70 CUL1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX4 ALOX12B ALOX15 ALOX12 GPX2 GPX1 ALOXE3 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) CYP51A1 EBP LBR DHCR7 MSMO1 NSDHL HSD17B7 TM7SF2 SC5D DHCR24 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules VASP ITK TRAC CD3G CD3E CD3D PLCG1 TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 EVL HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 NCK1 WAS PAK1 PAK3 LCK PLCG2 PAK2 ZAP70 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CACNA1D CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) RPS6KA1 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 SGK1 MAPK1 NAB1 NAB2 LYL1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 PPP2CA EGR3 PPP2CB JUND EGR4 FOSL1 ID2 ID1 MEF2C CDK5 ID4 FOSB ID3 CDK5R2 TCF12 CHD4 MAPKAPK2 REST ATF1 PPP2R1B PPP2R1A SH3GL3 VGF EP300 JUNB MAPK14 MAPK11 MEF2D FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs NEDD4L STUB1 ITGB8 ITGB5 FURIN PMEPA1 CBL BAMBI STRAP UBA52 TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 PPP1CA USP15 ITGA8 PPP1R15A PPP1CB PPP1CC TGFB2 UBB TGFB3 UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD4 SMAD3 SMURF2 SMAD7 SMURF1 NEDD8 TGFBR3 FKBP1A XPO1 LTBP4 ITGB3 ITGB1 LTBP3 LTBP1 ITGAV DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG1 UBC RPS27A RNF41 ERBB2 USP8 AKT1 AKT2 UBA52 NRG2 UBB AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors OXTR OXT AVPR1B AVP AVPR2 AVPR1A EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP8B1 TBXAS1 CYP4F3 CYP4A22 CYP4B1 CYP4F8 CYP4F2 CYP4A11 PTGIS CYP4F12 CYP4F22 CYP4F11 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment IKBKB RIPK1 UBC UBE2D1 TICAM1 RPS27A TLR3 UBE2V1 TRAF6 UBA52 BIRC2 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense SFN FNTA GBP1 FURIN GBP5 PIM1 PGGT1B GBP2 FNTB GBP4 GBP3 CASP1 ACTG1 ACTB PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 HEXB NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 RRP8 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 SUV39H1 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 SIRT1 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes PCBP4 TP53 CDKN1A ZNF385A RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 TEAD3 TEAD4 CCN2 RUNX3 WWTR1 TEAD1 TEAD2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity UBC PTPN2 SH3KBP1 RPS27A SH3GL3 EPS15 USP8 CBL SH3GL2 SH3GL1 UBA52 STAM PTPRJ LRIG1 STAM2 MET HGS HGF PTPN1 UBB NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 UBC RPS27A CBL UBA52 PTPRJ SLA ABL2 CSK SLA2 SOCS2 SOCS6 FLT3LG SH2B3 FLT3 UBB FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER CCNH RAD23A RAD23B PARP1 CETN2 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A DDB2 PIAS3 SUMO3 SUMO2 PARP2 USP45 UBE2I RPA1 PIAS1 RNF111 CHD1L SUMO1 RPA2 DDB1 UBE2V2 XPA XPC CUL4A RPA3 RBX1 ERCC4 ERCC1 UBE2N ERCC5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TICAM2 TICAM1 RIPK3 CASP8 LY96 FADD CD14 TLR4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 SLBP CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 PTPN12 NRG2 BTC TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation GP5 SERPINA5 GP9 SERPING1 A2M KLKB1 PRCP GP1BA KNG1 SERPINC1 C1QBP F9 PROC F10 SERPIND1 PROS1 F8 F2 VWF SERPINE2 GP1BB F12 F11 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions BAG4 FGFR1 ERLIN2 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling EPHB6 EFNB2 NCK2 EFNB1 ARHGEF7 EFNB3 EPHB2 EPHB1 SDCBP EPHB4 EPHB3 PAK1 PAK3 RAC1 FYN MYL12A GIT1 PAK2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation RIPK1 TICAM2 TRAF2 TNFRSF10B TICAM1 TNFSF10 TNFRSF10A LY96 FADD CD14 TRADD FAS FASLG CASP8 TLR4 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 ERBIN PRKCA SOS1 PTK6 STUB1 HBEGF SHC1 HSP90AA1 ERBB2 EGF USP8 PIK3R1 EGFR MEMO1 CDC37 NRAS PLCG1 UBA52 MATK RHOA PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 SRC YES1 HRAS NRG1 FYN GAB1 PRKCE DIAPH1 GRB7 AKT1 EREG NRG3 PIK3CA NRG4 NRG2 BTC AKT3 PRKCD DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN IL10 YES1 HCK SYK AHCYL1 FYN FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen GP5 GP9 ITGA1 LYN GP1BA GP6 ITGA10 FYN ITGA2 ADAMTS13 FCER1G VWF ITGB1 GP1BB PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs PAPOLA SYMPK NCBP1 CSTF2T NCBP2 CLP1 FIP1L1 PABPN1 CPSF4 CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 PCF11 CPSF2 CSTF2 WDR33 CSTF1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors NR1H2 NR5A1 RXRA PIAS4 NR2C1 PIAS3 ESR1 SUMO3 SUMO2 UBE2I VDR PIAS1 HDAC4 NR4A2 SUMO1 NR3C2 THRB RORA RARA NR3C1 PGR PPARG AR PPARA DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K POLR2L GTF2H1 CAVIN1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 TTF1 ERCC3 ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations DAG1 POMT2 POMT1 POMGNT1 MGAT5B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation NFATC2 AHCYL1 NFATC3 PPP3CA PPP3CB NFATC1 ITPR1 ITPR2 ITPR3 PPP3R1 CALM1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 CYSLTR1 CYSLTR2 DPEP1 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PTK6 CDKN1A CDC25B CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 FZR1 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT4 WNT3A LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WIF1 SOST TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand LBP CD36 LY96 TLR1 CD14 GSDMD GSDME S100A9 APOB TLR6 S100A8 TLR2 TLR7 FGB HMGB1 S100A1 FGA FGG TLR4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport ABCB6 ABCB4 SEL1L KCNJ11 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 VCP ABCC2 ABCG8 ABCC6 EIF2S2 EIF2S1 EIF2S3 ABCG5 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 ABCA3 ABCC3 ABCC1 ABCG1 ABCD3 PSMD8 PSMD6 ABCC4 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 ABCD2 ABCA6 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 ABCC5 PEX3 UBC ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 SEM1 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 ABCA12 PEX19 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 GFPT1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 CILP PIK3CA TLR9 PIK3C3 TRIB3 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly SERPINB1 CASP4 CALM3 CALM2 CALM1 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand TLR7 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin FDX1 FDX2 FDXR HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM5D PHF8 UTY KDM4B H4C9 KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 KDM7A KDM3A KDM1A KDM1B KDM4A KDM4C H3C8 KDM5B KDM5A KDM6A PHF2 KDM6B KDM5C KDM3B H3C15 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 FZR1 PLK1 FBXO5 CCNB1 CDC20 CDK1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle CLTC IQGAP1 SH3RF1 VANGL1 ARHGEF7 PIK3R1 RHOV MAP3K11 SPTAN1 MYO9A TPM4 GIT1 TPM3 TXNL1 WASL ARHGAP12 CDC42 DEPDC1B ZNF512B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 PARD6B PAK6 PAK1 CCP110 CEP97 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle DSG1 VANGL1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 ROCK1 TMOD3 TXNL1 PKP4 DDX4 RASAL2 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B EPHA2 WDR6 DST UBXN11 DLG5 PICALM ARHGAP21 TNFAIP1 SEMA4F PTPN13 RND3 NISCH KTN1 CKB CKAP4 PLEKHG5 KCTD13 SCRIB VANGL2 FLOT2 DSP CAV1 CCDC88A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 GPAM MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab ERBIN HSP90AA1 ERBB2 CDC37 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP3 CHMP6 CHMP7 TUBB8 IST1 TUBA8 TUBA1C LEMD2 TUBA1B TUBB8B TUBA1A TUBB2B TUBB2A SPAST CC2D1B TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D CHMP4C TUBA3C CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A TUBB4B TUBB4A SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 CSF1R SHC1 LYN STAT3 CBL INPP5D PIK3R1 IL34 UBA52 GAB3 GRAP2 STAT1 KRAS UBB PTPN11 PIK3CB UBC RPS27A PIK3CD THOC5 SRC YES1 HCK FYN INPPL1 PLCG2 GAB2 PIK3CA CSF1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 BBS2 BBS1 CCT2 CCT8 RAB3IP CCT5 BBIP1 BBS9 CCT4 BBS7 CCT3 TTC8 BBS5 BBS4 MKKS SMO TCP1 SSTR3 LZTFL1 BBS10 BBS12 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACSM6 HADHB MECR ACADL HADHA ACADVL ECHS1 ACADM ACSM3 ACADS HADH SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 HDAC1 NEURL1B DNER HES5 TLE4 APH1A TLE2 HDAC3 DLL4 MIB2 ITCH PSENEN TLE1 DTX1 NCSTN MIB1 DTX2 APH1B HEYL PSEN2 DLK1 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 DTX4 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 ARRB1 RBX1 ARRB2 HIF1A HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 NUMB HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NBEA NOTCH1 CUL1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib ERBIN HSP90AA1 ERBB2 CDC37 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FPGT FCSK GFUS FUOM MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) MYD88 TLR5 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5E NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation FGF19 FGF18 FGFR4 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 KLB FGF20 FGF16 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG1 HRAS SOS1 HBEGF SHC1 NRAS NRG3 EREG NRG4 BTC NRG2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CDKN1A CDKN1B ARID3A E2F1 CDK2 E2F7 E2F8 CCNA2 TP53 CCNA1 CCNE2 CCNE1 ZNF385A CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling RELA NFATC1 MAP3K7 NFKB1 UBA3 UBE2M CDC34 NFATC2 CHUK IKBKB CARD11 MALT1 ITPR1 RELB ITPR2 CLEC7A ITPR3 CARD9 NFKBIA MAP3K14 TAB1 UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PLCG2 PSMD3 PSMD1 CALM1 PYCARD PRKCD PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 TRAF6 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 NFKB2 PSMB6 PSMB7 IL1B PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB TAB3 SKP1 PDPK1 TAB2 CASP8 PPP3R1 UBE2N CUL1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UXS1 UGDH UGP2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events GNAQ ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 GNAT3 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 CAMK2A GNAI3 GNAI1 GNAI2 CALM1 CAMK2G PRKCD PRKCA PLCB4 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 NBEA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle ERBIN ARHGAP26 ARHGEF3 VANGL1 ARHGEF1 ARHGAP32 ARHGEF2 PIK3R2 ARHGEF5 PIK3R1 RHOB ROCK1 CAVIN1 ROCK2 MYO9A ABR RTKN ECT2 ARHGEF28 MCF2 NET1 RHPN2 ARHGDIG SOWAHC STARD8 CIT ARHGEF25 PKN3 TFRC IQGAP3 SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 STOM MCF2L RACGAP1 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis FUT2 FUT1 ABO NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAP2K1 MAP2K2 MAPK3 BRAF DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type MMAB SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors SCARF1 APOB CALR HSP90AA1 HSPH1 HYOU1 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways HBEGF GBP1 FURIN HSP90AB1 HBB ATP6V1H MAPK1 STAM2 CTSG CTNNB1 MET RNF213 MAPK3 STX1A B2M CDH1 MRC1 SRC GBP2 UBE2D2 GBP6 GBP4 HBA2 STX1B NOS2 CBLL1 LTF TLR2 GUCY2C SYT2 NHERF4 GSK3A CALM1 ENO1 SNAP25 SH3KBP1 TRIM27 HSP90AA1 KPNA1 SYT1 CD9 CBL CTNND1 UBA52 STAM DUSP16 VPS33B CORO1A PGK1 HGS RAB5A KPNB1 SV2C SV2B SV2A VAMP1 UBB TXNRD1 MAP2K4 UBC RAB7A RPS27A SH3GL3 UPK1A EPCAM EPS15 SH3GL2 SH3GL1 SFPQ VAMP2 MAP2K7 EEF2 CASP4 MAP2K1 MAP2K2 CALM3 CALM2 PDCD6IP MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB RABGGTA NDRG1 BCL6 PERP TP53I3 BIRC5 TP63 TP73 PPP1R13B TP53 TP53BP2 BCL2L14 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE MTR MTRR SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 PI4KA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K7 FURIN MAP2K1 MAP2K2 CALM1 PDCD6IP CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle PCNA NPM1 YWHAE EML4 YWHAQ CDCA5 MYBL2 NCAPG YWHAG ARPP19 ZNF385A NCAPH YWHAH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A UBE2V2 PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 UBE2N CHMP3 CHMP6 CHMP7 PLK3 CDC7 HSPA2 FBXL18 FBXL7 PHF20 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH PIAS4 POLR2A POLR2B POLR2C POLR2D BRCC3 LYN POLR2E POLR2F POLR2G POLR2H CDKN2B POLR2I POLR2J POLR2K POLR2L BABAM1 CDK7 BABAM2 MNAT1 UIMC1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 RUVBL1 ABL1 WRAP53 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E CLSPN NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 MDM2 MDM4 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 ABRAXAS1 NUP37 ERCC6L RBBP7 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 CHEK2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MLH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 JAK2 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 PPP1CB CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 HJURP RFC5 RMI2 PPP2R2A RFC3 PPME1 GTSE1 RFC4 RMI1 BORA TERT FKBPL RFC2 FBXW11 OPTN TOP3A OBI1 HMMR RPA1 HUS1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B RAD50 TICRR MCM7 RAD51 MCM8 RAD51C GMNN RPA3 RAD17 SKP1 RAD1 CCNA2 ATM CCNA1 MCM3 DNA2 RAD9B MCM4 RHNO1 MCM5 MCM6 ATR RAD9A MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 FKBP6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B HERC2 PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MDC1 MYC YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 PIF1 FIGNL1 GAR1 CTC1 KMT5A TEX12 TEX15 RNF168 NSD2 CENPW CENPX RUVBL2 OIP5 MSH4 MSH5 HSP90AA1 NHP2 ANKRD28 NOP10 SYCP2 CDC25C SYCP1 CDKN1C SYNE2 RB1 SYNE1 CDKN1B PPP6C PPP6R3 CCND3 SMC1B FZR1 MND1 CCND2 E2F1 REC8 E2F2 SYCP3 E2F3 RTEL1 SKP2 CHTF8 DAXX TP53BP1 ATRX STAG3 CDK6 RSF1 TFDP1 DMC1 PSMC3IP CCNE2 TFDP2 MLH3 CDK4 MIS18A NEK11 CCNE1 H2AX PRDM9 DSCC1 SHQ1 CPAP LIG1 DKC1 MAX H2AB1 SYCE3 H2AC19 SYCE2 POLD3 COP1 H2BC26 POLD4 H2AC14 SYCE1 POLD1 H2BC12L SPO11 POLD2 RCC1 CHTF18 H2BC21 SUN2 EP300 SUN1 RNF8 H3-3B STN1 H3C8 TEN1 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 SMARCA5 GSK3B CSNK1A1 PHLDA1 PCBP4 AKT3 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP ZNF141 HDAC1 ZNF382 H2AC20 ZNF547 ZNF418 ZNF224 MBD3 ZNF354A ZNF136 ZNF649 GATAD2B GATAD2A CHD3 SUMO2 UBE2I ZNF778 HDAC2 ZNF454 ZNF28 CBX5 CHD4 ZNF273 SETDB1 ZNF816 ZNF519 ZNF610 ZNF264 ZNF680 TRIM28 MTA2 ZNF30 ZNF257 RBBP4 MTA1 ZNF33A MTA3 RBBP7 ZNF331 H2AX ZNF93 H2AB1 H2AC19 H2BC26 ZNF708 H2AC14 H2BC12L H2BC21 ZNF324 ZNF534 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ZNF320 H2BC17 H2BC12 H2BC13 ZNF669 ZNF765 H2BC14 H2AJ H2BC15 ZNF317 H2BC11 ZNF425 H3C15 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism TCN2 CD320 MCCC2 BTD ACACA PC PCCA HLCS CUBN CBLIF MMAB MCCC1 AMN PCCB MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 PABPN1 EIF4E PAIP1 EIF4B EIF4A3 PABPC1 DIS3L2 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH PECR SLC25A17 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A6 SLC12A3 SLC12A1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 SNU13 DCAF13 NOP14 UTP6 UTP4 KRR1 UTP3 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP2 TRMT112 NOP56 NOP58 GAR1 NHP2 NOP10 RPS14 DKC1 RPS2 RPS9 RPS7 RPS6 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FURIN H2BC1 INS H2AC20 APH1A PSENEN APOA1 NCSTN APOA4 APH1B HSPG2 ADAM10 APOE NPPA SIAH1 PRL CALB1 NAT8B BACE1 APCS TSPAN33 B2M GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI LTF ITM2B UBA52 SIAH2 LYZ FGA CALCA H2AX UBB GSN SEMG1 H2AB1 UBC H2AC19 IAPP H2BC26 H2AC14 RPS27A H2BC12L H2BC21 PRKN TTR H3-3B H3C8 H2AC8 MFGE8 H2AC6 H2AC7 TSPAN14 H2BC17 APP H2BC12 H2BC13 H2BC14 CST3 SAA1 H2BC15 USP9X H2BC11 UBE2L6 H3C15 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB NBEA CALM1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation RELA MAP3K7 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 CARD11 IGKV2D-28 MALT1 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 TRPC1 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK IGLC1 BTRC IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PRKCB HRAS PPP3CA PPP3CB PPP3R1 VAV1 SOS1 NFATC1 PIK3R1 NFKB1 NRAS NFATC2 CHUK CD19 IKBKB FKBP1A PSMD8 PSMD6 PSMD7 DAPP1 RASGRP3 PSMD2 REL NFKBIE PSMD3 CD22 PIK3AP1 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD FBXW11 PTPN6 ADRM1 PPIA PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation IFNA2 IFNA8 TRAF2 IFNA13 IFNA14 IFNA16 IFNA17 TRAF6 IFNA10 IFNA21 IFNB1 IFIH1 TRIM4 CREBBP TBK1 EP300 IRF3 MAVS RNF135 RIGI TRIM25 IKBKE IRF7 IFNA5 TANK SIKE1 IFNA4 IFNA7 IFNA6 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t PGM1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis HSD3B2 HSD3B1 CGA LHB CYP21A2 CYP11B2 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 HHAT VCP IHH SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 DTX4 TBK1 NFKB1 IRF3 NFKBIA NLRP4 DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling IL21R LGALS9 SOS1 HAVCR2 IL15RA PTK2B STAT5A STAT5B IL15 SHC1 IL5 STAT3 IL3RA PIK3R2 INPP5D IL2RB SOS2 PIK3R1 IL9 GRB2 IL9R JAK3 STAT4 JAK2 JAK1 IL2RG STAT1 CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 SYK LCK INPPL1 GAB2 PIK3R3 PIK3CA IL21 IL2RA IL5RA CSF2RB CSF2RA METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins VKORC1L1 UBIAD1 LRP1 RETSAT APOA2 APOM APOA1 TTPA BCO2 APOA4 BCO1 HSPG2 VKORC1 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation LCK AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 ARF1 CD4 ATP6V1H ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors GRIN3A APBA1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D KIF17 GRIN1 DLG1 GRIN2A CASK LIN7A DLG2 LIN7C NBEA DLG3 LRRC7 LIN7B DLG4 NEFL CAMK2G GRIN3B DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation UHRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 DNMT3L H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DBT DLD DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis NCAN CHST15 CSPG4 BGN DCN BCAN VCAN DSEL CHST14 DSE UST CSPG5 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 KPNA2 H2BC15 TP53 H2BC11 ATM UBE2N PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CDK2 CCNE2 RB1 CCNE1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration ITGA5 ITGBL1 MMP13 AKT1 AKT2 CBFB AKT3 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry AGRN FURIN NCL EGFR GPC1 LY96 GPC3 GPC2 CD14 GPC5 RAB5B GPC4 RAB5C GPC6 CX3CR1 HSPG2 IGF1R SDC1 RAB5A SDC4 SDC2 SDC3 TLR4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED19 MED18 SREBF2 MED11 WNT1 RELA MED9 MED29 MED28 MED22 TGFB1 MED21 CDK19 MBD3 MED13L ANGPTL4 LPL GATAD2B GATAD2A CDK8 SMAD1 SMAD4 LEP CHD4 CIDEA SMARCD3 CCND3 MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MTA3 CARM1 EBF2 RBBP7 BMP7 CDK4 KLF4 EP300 MED1 MED30 MED31 MED8 MED4 MED6 MED7 ELOVL3 CEBPA HNRNPU RXRA NFKB1 HDAC1 KLF5 HDAC3 CEBPB TBL1X PCK1 NCOA1 EGR2 FABP4 NCOR2 COX7A1 CHD3 NCOR1 TBL1XR1 PLIN1 HDAC2 THRAP3 FAM120B PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC ADIPOQ HELZ2 MED16 MED15 CREBBP MED17 CHD9 MED12 MED14 MED13 TNF MED10 EBF1 WNT10B NR2F2 ADIRF SLC2A4 ZNF638 TGS1 CEBPD ZNF467 MED27 MED26 MED23 MED25 MED24 MED20 PPARG PPARA DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction SOS1 CRK STAT5A STAT5B STAT3 PIK3R2 PIK3R1 PDGFB NRAS PLCG1 STAT1 PTPN11 PIK3CB RAPGEF1 NCK2 NCK1 RASA1 SRC PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling JUN GNG13 ZNF217 FKBP5 EBAG9 GNB2 KDM4B YY1 GNB1 GNB4 DDX5 GNB3 GNB5 GNGT1 GPAM GNGT2 SPHK1 GNG3 CXCL12 ESR1 GNG2 GNG5 GNG4 GNG7 GNG8 POU2F1 NOS3 TBP HSP90AA1 EGF EGFR CDKN1B S1PR3 CARM1 H2AX H2AB1 H2AC19 MMP2 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 MED1 H2AC8 PRKCZ H2AC6 CTSD H2AC7 HRAS H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 MMP3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 PIK3R3 PIK3CA CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 HBEGF H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 HDAC1 NRAS H2AC20 HSP90AB1 KDM1A MAPK1 GNAT3 CCND1 PTGES3 NRIP1 FKBP4 NCOA1 SRF MAPK3 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 ESR2 AGO2 SRC TNRC6A TNRC6B GNAI3 XPO1 GNAI1 GNAI2 AKT1 CALM1 AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 MMP9 KANK1 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG KAT2B FOXA1 ZDHHC7 TLE3 KPNA2 PPID TGFA USF1 CAV2 FOS FOXO3 GREB1 ELK1 IGF1R GNG10 CHD1 PTK2 MMP7 EREG PGR TFF3 UHMK1 TFF1 BTC ZDHHC21 CAV1 GNG12 CXXC5 EPGN AKT3 GNG11 USF2 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors HRH3 HRH2 HRH4 HRH1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters SLC24A2 SLC24A3 SLC41A2 SLC41A1 SLC30A10 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 CP SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC40A1 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC8A1 SLC8B1 SLC24A1 SLC8A2 HEPH SLC24A4 SLC11A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SRI SLC9A8 SLC9A9 SLC9A1 SLC24A5 SLC39A4 SLC8A3 SLC11A2 CALM1 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation POLE4 POLE POLE2 PRIM2 POLE3 PRIM1 POLA1 POLA2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 CAVIN1 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules LRFN1 PTPRS PTPRF GRIA1 GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG3 RTN3 DLG4 FLOT1 LRFN3 FLOT2 PTPRD GRIA3 LRFN2 GRIA4 LRFN4 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA PLA2G2D MIGA1 PLD1 PLA2G2E DDHD2 AGPAT2 PLA2G5 DDHD1 PLA2R1 PLA2G10 GPD1 GPD1L PLD6 GPAM PLA2G2A GPAT2 LPCAT1 PLA2G4A PLD2 ALPI GPD2 GNPAT LIPI ACP6 LIPH PLA2G12A PLA2G4D GPAT4 PLA2G4B GPAT3 AGPAT5 PLA2G1B LPCAT4 AGPAT1 AGPAT3 AGPAT4 LCLAT1 PLA2G2F MIGA2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism ACSL1 FADS1 ELOVL5 ELOVL2 ABCD1 ELOVL3 ELOVL1 FADS2 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity HTT HDAC1 HDAC3 GPS2 SIN3A LBR HIPK2 PRKACA TBL1X AURKB FOXG1 NCOR2 TNRC6C MOV10 NCOR1 AGO3 TBL1XR1 AGO4 CAMK2B AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A CAMK4 CALM1 CAMK2G SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections IFNA2 IFNA8 RELA IFNA13 IFNA14 IFNA16 SAP30L IFNA17 NPM1 ITCH IFNA10 IFNA21 IFNB1 ISG15 NR3C1 PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP YWHAE VPS41 NPIPB3 VPS45 NMI PARP10 PARP6 SFTPD CHD4 IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 MTA2 VPS33B RIPK3 REST KPNB1 FNTA CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A VAV1 UBE2N CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 PTGES3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 FKBP4 OST4 EDEM2 MOGS SDC4 ZDHHC11 IFNGR1 DDOST SDC2 IFNGR2 MGAT4C SDC3 ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 SUMO1 GPC5 GPC4 GPC6 KEAP1 RBX1 TRIM25 SDC1 VHL ISCU BTK IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TLR8 KPNA2 MAP3K7 VCP NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA MAVS TAB1 GJA1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C PYCARD NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 TRAF3 RANBP2 TRAF6 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 BECN1 NUP50 NUP35 RBBP4 NUP54 NUP37 NOD1 RBBP7 NOD2 NCK1 AKT2 PDPK1 RPS27 ITGB1 TLR9 PIK3C3 SOS1 SNRPD2 SNRPD1 SNRPD3 PIK3R4 BST2 PRMT1 CHUK TJP1 PCBP2 PTPN11 CASP1 JAK2 ZCRB1 SYK SNRPG SNRPE PPIH PPIG SNRPF AP2A1 SNRPB AP2A2 DDX5 AP2M1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 SAR1B IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 TLR1 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 TLR2 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 SAP18 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 IGLC2 S1PR1 JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 IGLV3-19 MTA3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 RPS4Y1 IGLV3-1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 RPS17 IGKC RPS15A IGKV1-39 IGLV3-21 RPS16 RPS19 IGKV1-33 BRD4 RPS18 RPS3 CRBN RPS2 IGLC7 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 RPS13 IGLC6 RPS12 IGKV1-5 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 PDCD1 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 HLA-H HLA-B HLA-C ATG14 HDAC1 HLA-F HSP90AB1 HLA-G HLA-E YWHAB FKBP1A IKBKE AKT1 IRF7 NUP214 SFN YWHAZ UBA52 TUBB UBB UBC RPS27A UBE2V1 PSMC6 CAV1 FURIN ATP1B3 ROCK1 ATP1B2 ROCK2 ATP1B1 CUL3 MBD3 STAT1 GATAD2B GATAD2A ZBP1 SEC23A TBK1 B2M IRF3 STING1 HLA-A FXYD4 FXYD3 FXYD2 FXYD1 PALS1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 UVRAG ANO5 MAP1LC3B ANO2 ANO3 HSP90AA1 ANO1 RB1 ATP1A4 ATP1A3 ATP1A2 FNTB SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 EP300 IL6R RUNX1 NRP1 MASP1 NFKB1 SRPK1 KDM1A HSPG2 ITGA4 AGRN CHD3 HDAC2 ST6GALNAC2 SIKE1 GSK3B CSNK1A1 ST6GAL1 ST6GALNAC3 ST6GALNAC4 ARID4B SAP30 CREBBP SP1 ST3GAL4 NFE2L2 BCL2L1 ST3GAL1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 TAB3 TAB2 CTSL IFNA5 IFNA4 IFNA7 IFNA6 AKT3 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib ERBIN HSP90AA1 ERBB2 CDC37 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines STAT6 TBK1 STING1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A GALNS BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins KPNA7 KPNA4 KPNA5 KPNA3 RPN2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 SPCS2 PRKG2 SPCS1 OST4 SEC11A SEC11C DDOST TMEM258 DAD1 OSTC CANX CALR ACOT2 STT3A STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 KPNA1 IPO7 DNAJB11 P4HA1 UBA52 P4HA2 P4HA3 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UBB UBC DNAJC3 RPS27A KPNA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling CAP1 ABL2 CLASP1 CLASP2 SLIT2 ABL1 ROBO1 CAP2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 LEF1 SOX10 SMARCC1 CTNNB1 SMARCC2 GPR143 ACTB SMARCE1 ACTL6A SYTL2 PMEL TFAP2A MYO5A RAB27A TYR AKT2 MYRIP MAPK14 DPF1 BCL7A DPF2 DCT BCL7C IRF4 BCL7B DPF3 SMARCA2 SMARCA4 TYRP1 MLANA USF1 MLPH SS18L1 ARID1A ARID1B ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs PRKAG3 CAMKK2 PRKAB2 PRKAA1 PRKAA2 CALM1 PRKAG1 PRKAB1 PRKAG2 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 TXNRD1 RPS17 SARS1 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A PAPSS2 RPL6 PAPSS1 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 EPRS1 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2A UBE2C UBE2L3 UBE2E1 UBE2D1 UBE2W USP7 USP5 UBE2S UBA52 UBA1 UBE2K UBE2Z CDC34 UBE2Q2 UBE2E3 UBB UBE2R2 UBC UCHL3 RPS27A UBE2T OTULIN UBA6 UBE2D2 USP9X UBE2H UBE2G1 UBE2G2 UBE2B PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds CYB5B CYP51A1 CYP4B1 CYB5R3 CES3 CYP27A1 CYP39A1 CYP3A5 AOC1 CYP2A13 CES1 FMO3 CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP7A1 CYP1B1 CYP2C19 CYP2D6 CMBL ALDH3A1 FDXR POR CES2 MAOB MTARC2 MAOA CYP8B1 MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP46A1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 RXRA ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 ARNT2 PTGES3 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR CYP4F12 PTGIS PTGS1 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP4F11 AIP CYP11B1 TBXAS1 ADH1C ADH1A ADH4 PAOX ALDH1A1 ALDH2 CYP3A4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR2 TGFB1 TGFBR1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) GP5 SOS1 GP9 CRK SHC1 MPL FN1 GP1BA THPO RASGRP2 RASGRP1 RAP1B RAP1A CSK ADRA2C FGB ADRA2B RAPGEF3 FGA ADRA2A RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 F2 AKT1 PTK2 ITGB3 ITGA2B GP1BB SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R HRAS SOS1 IGF2 IGF1 IGF1R NRAS GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 TJP1 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose DPM3 DPM1 DPM2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH JUN SEL1L WWC1 NEURL1B DLGAP5 HES5 PTCRA MIB2 ITCH PBX1 MIB1 HEYL ATP2A3 NEURL1 TACC3 MAMLD1 ATP2A2 ATP2A1 YBX1 ELANE NUMB PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC MAML2 NOTCH2NLB MAML1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC1 GZMB APH1A DLL4 PSENEN NCSTN APH1B CCND1 PSEN2 ADAM10 PSEN1 RBPJ TMED2 FCER2 TNRC6C MOV10 RFNG MFNG AGO3 B4GALT1 MDK AGO4 ACTA2 MYC AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 HIF1A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 KAT2B KAT2A HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 NBEA FURIN DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 STAT1 CDK8 SMAD3 DTX4 JAG2 ADAM17 ARRB1 ARRB2 WWP2 EGF EGFR HDAC5 PLXND1 HDAC8 HDAC9 HDAC6 HDAC7 E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 HDAC10 EP300 HDAC11 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 TBL1X NCOR2 FABP7 NCOR1 TBL1XR1 SNW1 HDAC4 HDAC2 FLT4 HES1 CCNC CREBBP ST3GAL4 LFNG ST3GAL6 JAG1 ST3GAL3 SEM1 DLL1 SKP1 CUL1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA NGFR LINGO1 NGF MAG OMG RTN4 MCF2 RHOA DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis JUN PRDX2 PRDX1 CDK5 CDC25C CDKN2A CDC25B CDC25A C1QBP APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 TP53 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) RPS6KA1 CLTC CLTA AP2A1 AP2A2 NGF AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB VGF EP300 JUNB HRAS FRS2 MAP2K1 CRKL MAP2K2 PIK3CA SOS1 DUSP4 DUSP3 VRK3 DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 ADCYAP1 ADCYAP1R1 YWHAB SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA ATF1 BRAF MAP2K5 RAPGEF1 MAPKAPK3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTRK2 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin KLF4 INS GCG PCSK1 BCHE IGF1 SPCS3 SPCS2 LEP SPCS1 SEC11A UCN SEC11C ACHE MBOAT4 PLA2G7 CRHR2 GH1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation BTRC DDB1 COPS7B COPS7A CUL4A COPS3 LRR1 COPS6 CCNF COPS5 COPS8 FBXO7 FBXO9 WSB1 FBXO2 CDKN1A FBXL18 FBXL7 SQSTM1 FBXL8 FBXL4 DTL LRRC41 UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 HIF3A PSMD7 ELOB ELOC SOCS2 PSMD2 KLHL2 RBX1 SOCS6 KLHL3 PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL KLHL9 SPSB2 SPSB1 DCAF8 KBTBD6 DCAF5 KLHL5 DCAF4 PSMA5 DCAF6 PSMA6 WSB2 PSMA3 KBTBD7 OBSL1 PSMA4 KBTBD8 DCUN1D5 PSMA1 SPSB4 DCUN1D3 DCUN1D4 PSMA2 DCUN1D1 DCUN1D2 FBXO27 UBA52 COMMD8 PUM2 NPLOC4 PSMD12 DDA1 PSMD11 ANKRD9 FBXO21 UBXN7 PSMD14 COMMD2 FBXO22 COMMD1 PSMD13 COMMD6 COMMD7 PSMA7 COMMD4 FBXW12 COMMD5 PSMB6 SPSB3 FBXW8 PSMB7 CCDC8 CISH PSMB4 FBXO17 CUL9 DPP3 UFD1 PSMB5 FBXO15 UBD NAE1 DCAF7 UBB SOCS5 PSMB2 WDTC1 PSMB3 LMO7 CCDC22 FBXO10 COMMD10 UCHL3 FBXO11 UBC TULP4 FBXO4 PSMB1 KLHL41 DCAF16 KCTD7 DCAF17 FBXO6 DDB2 RPS27A FEM1C DCAF10 KLHL42 DCAF11 FEM1A FBXW4 CUL7 FEM1B FBXW5 CUL5 NEURL2 NEDD8 FBXW10 ADRM1 ERCC8 FBXW7 PSMC5 FBXW9 PSMC6 KLHL11 PSMC3 PSMC4 FBXW2 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 FBXL3 UBA3 FBXL5 MUL1 UBE2M GPS1 KBTBD13 CUL3 VCP COPS4 COPS2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 ASB16 FBXL20 ASB10 WDR5 SENP8 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 SKP2 RBBP5 ASB1 RBBP7 COP1 SOCS3 COMMD9 FBXO32 BIRC5 DCAF13 COMMD3 KCTD6 AMER1 UBE2D1 BRCA1 CAND1 NFE2L2 FBXW11 FBXL21P PALB2 SEM1 SKP1 CUL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC MMACHC RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle HNRNPC CCT6A CCT7 RBMX DBN1 HSP90AA1 CDC37 HSP90AB1 TWF1 CCT2 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B CUL3 PHIP TXNL1 SRRM1 TRA2B ACTG1 MYO6 STK38 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation TRAF2 RELA MAP3K7 NFKB1 TRAF6 UBA52 USP14 NFKB2 CHUK NOD1 NKIRAS1 NOD2 NKIRAS2 USP18 IKBKG UBB IKBIP RIPK2 IKBKB UBC RPS27A ALPK1 LRRC14 NLRX1 IRAK1 UBE2V1 NLRC5 NFKBIA AGER IRAK2 TIFA S100A12 TAB1 APP S100B SAA1 TAB3 TAB2 HMGB1 TP53 NFKBIB CASP8 UBE2N THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 TBXA2R GNG7 AAMP GNA11 GNGT1 GNG8 GNA13 GNGT2 GNG10 GNG12 GNG11 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes SRPRB ATP6V0D1 TPP1 CXXC1 PREB HDGF PPP2R5B KDELR3 ACADVL SHC1 ADD1 PDIA6 DNAJB11 DCTN1 SERP1 WFS1 SEC31A TLN1 DNAJC3 EXTL2 CUL7 FKBP14 GOSR2 MYDGF EXTL3 PLA2G4B HYOU1 EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 GSK3A EDEM1 WIPI1 YIF1A SYVN1 ARFGAP1 PDIA5 CTDSP2 SRPRA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 FGF18 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A TP53 ING2 PIP4K2B MAP2K6 PIP4P1 EP300 PIP4K2C ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B PPP2R1A TICAM1 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA PPP2CB TLR3 MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes CREBBP TALDO1 MAFG PGD NFE2L2 TKT EP300 G6PD CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL STAT3 GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 HDAC3 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 GBA1 ACTB CCNE1 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 GNG10 GNG12 GNG11 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells FGF10 ONECUT3 ONECUT1 PDX1 NKX6-1 PTF1A HNF1B RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G NFIX POLR3H SSB POLR2K NFIA POLR3K POLR2L NFIB NFIC POLR1C POLR1D ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription DHFR PCNA ORC1 TK1 CDT1 CDC6 HDAC1 CDK1 RRM2 E2F1 RBBP4 CDC45 FBXO5 TFDP1 TFDP2 LIN54 LIN37 CCNE1 LIN9 POLA1 TYMS LIN52 E2F4 E2F5 E2F6 CCNA1 RBL2 RBL1 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids CYP2F1 CYP4A22 CYP4B1 CYP2D6 CYP4F12 CYP4F22 CYP4F3 CYP4F8 CYP2A13 CYP2B6 CYP2J2 CYP4F2 CYP4A11 CYP2A7 CYP4F11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates MUS81 FIRRM BLM SLX4 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS HRAS SOS1 NTF4 NTRK2 BDNF NRAS DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency MCCC2 PC ACACA PCCA HLCS MCCC1 PCCB CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants ALK VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly CASP5 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO3 FMO1 FMO2 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation DRG2 RCCD1 ZC3H15 JMJD6 ASPH U2AF2 RIOX2 RPS6 F9 RPL8 RWDD1 JMJD4 KDM8 RPS23 JMJD7 RIOX1 ETF1 OGFOD1 RPL27A DRG1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR2 TGFB1 TGFBR1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP RBPJ MAML2 MAML1 KAT2B ONECUT3 KAT2A ONECUT1 HES1 SNW1 EP300 NEUROG3 HNF1B MAMLD1 MAML3 NOTCH1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 TACC3 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 CUL1 NOTCH4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN52 HDAC1 CDK1 E2F4 E2F5 E2F1 RBBP4 CCNA2 TFDP1 TFDP2 LIN54 LIN37 MYBL2 LIN9 RBL2 RBL1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2E1 CYP3A7 RXRA CYP51A1 CYP2F1 CYP4B1 CYP2W1 ARNT2 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP27A1 CYP39A1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR PTGIS CYP4F12 CYP3A5 CYP2A13 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP7A1 CYP1A1 CYP1B1 CYP2C19 CYP4F11 CYP11B1 TBXAS1 CYP2D6 FDXR POR CYP8B1 CYP2C18 CYP2B6 CYP46A1 CYP2S1 CYP4V2 FDX1 CYP3A4 CYP3A43 FDX2 CYP2A7 CYP2A6 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions CACNG2 CACNG3 CACNG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 STX1B CACNG8 DLG4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI PLA2G2D PLA2G2E MBOAT7 PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4C PLAAT3 PLA2G2A PLA2G1B PLBD1 PLA2G2F PLA2G4A DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus RB1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME3 ME2 VDAC1 WDR26 PDHB RMND5B PC LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 LDHC MPC1 PDK1 LDHB MPC2 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GLO1 GID4 GID8 UBC FAHD1 MPC1L RPS27A LDHAL6A LDHAL6B PDK4 GPT DLD SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT KIT DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 STRAP HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 TFAP2A HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A ARID1A FOXA2 TGIF2 EED RB1 RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX KLF4 H2AB1 SP1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis CYB5B SPTLC1 OSBP SPNS2 SPTLC2 SPTLC3 CSNK1G2 VAPA ABCG2 KDSR MFSD2B SPHK1 FA2H ORMDL2 ORMDL3 SPTSSB DEGS1 SPTSSA DEGS2 SPHK2 SAMD8 SGMS1 CERS3 ORMDL1 SGMS2 CERS4 ABCC1 CERS5 CERS6 CERS1 CERS2 PPM1L VAPB PRKD3 PRKD2 PRKD1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development HNF1A MAFA RFX6 INSM1 FOXA3 GCK ONECUT3 ONECUT1 HES1 PDX1 INS NKX6-1 PTF1A PAX6 SLC2A2 MAMLD1 RBPJ CREBBP MAML2 IAPP FGF10 MAML1 KAT2B KAT2A FOXO1 EP300 SNW1 AKT2 NEUROG3 HNF1B HNF4G MAML3 AKT1 FOXA2 NEUROD1 NOTCH1 NKX2-2 AKT3 PAX4 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PRKCA FES SOS1 STAT5A STAT5B PTPRU SH2B2 LYN CMA1 STAT3 PIK3R2 CBL FER PIK3R1 TEC GRAP NRAS GRAP2 JAK2 STAT1 SOCS1 CHEK1 MMP9 PTPN11 PTPN6 GRB10 YES1 RAC1 HRAS LCK FYN KIT SOCS6 SH2B3 GRB7 GAB2 PIK3R3 PIK3CA VAV1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 YWHAE YWHAQ YWHAG ZNF385A YWHAH BTRC UBE2V2 UBE2N HERC2 PLK3 CDKN1A CDKN2A CDC7 CDK2 CDC45 MDC1 PHF20 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 PSMD1 SFN YWHAZ PSMA5 PSMA6 PIAS4 PSMA3 PSMA4 BRCC3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 BABAM1 PSMB6 BABAM2 PSMB7 PSMB4 UIMC1 PSMB5 CSNK1E UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 CCNB2 CDC25A PKMYT1 WEE1 CLSPN MDM2 MDM4 NUP107 NUP160 RNF168 NUP85 NSD2 NUP43 RANBP2 SEC13 CDC25C NUP133 CDKN1B ABRAXAS1 TP53BP1 NUP37 ERCC6L ZWILCH BUB1B CCNE2 CDC20 NEK11 PPP1CC CCNE1 PPP2R1B H2AX PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 COP1 H2BC26 SGO2 H2BC12L DYNC1LI2 H2BC21 ZW10 MAD1L1 RNF8 CDCA8 PMF1 SKA1 CHEK2 SKA2 DSN1 H2BC17 H2BC12 H2BC13 H2BC14 RCC2 H2BC15 NDC80 ZWINT H2BC11 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 GSK3B CSNK1A1 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 GTSE1 RFC4 RMI1 PCBP4 RFC2 FBXW11 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 MCM7 MCM8 RPA3 SKP1 RAD17 RAD1 CCNA2 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 CLIP1 CUL1 ORC5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25C CDC25A CDC7 CDK2 CDC45 CHEK1 ATRIP CLSPN RFC5 RFC3 RFC4 RFC2 MCM10 RPA1 DBF4 HUS1 RPA2 MCM7 MCM8 RPA3 RAD17 RAD1 MCM3 MCM4 RAD9B MCM5 MCM6 ATR MCM2 RAD9A ORC5 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B SLC22A2 SLC22A1 MAOA PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination FZD5 FZD4 UBC FZD6 RPS27A USP8 FZD8 UBA52 RSPO3 WNT3A LRP5 RNF43 ZNRF3 RSPO2 RSPO1 LGR6 LRP6 LGR5 RSPO4 LGR4 UBB RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c ALG6 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest SFN PCNA CCNB1 EP300 PRMT1 CDC25C AURKA CDK1 E2F4 BAX TP53 CARM1 TFDP1 TFDP2 GADD45A RBL2 RBL1 ZNF385A OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism PM20D1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 MMR%REACTOME%R-HSA-5358508.3 MMR LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB NBEA CALM1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 KPNA5 ARIH1 KPNA3 PIN1 EIF2AK2 ISG15 MAPK3 STAT1 EIF4E IRF3 RIGI NUP205 POM121 NUP107 TRIM25 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 UBE2E1 NUP88 NUP43 RAE1 NEDD4 KPNA1 NDC1 RANBP2 SEC13 UBA52 PLCG1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 NUP35 NUP54 NUP37 JAK1 KPNB1 USP18 UBB EIF4E3 IFIT1 PPM1B EIF4E2 UBC FLNB MX2 RPS27A MX1 EIF4G3 EIF4G2 UBA7 EIF4A2 EIF4A1 KPNA2 EIF4G1 UBE2L6 EIF4A3 HERC5 UBE2N MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 HSPB1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 HSPA1A EIF4G1 PSMD2 PSMD3 PSMD1 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors LTB4R2 GPR17 CYSLTR1 CYSLTR2 LTB4R NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants ALK CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes CREBBP CITED2 BBC3 STK11 BCL6 FOXO1 EP300 NFYA NFYB NFYC BCL2L11 FASLG FOXO3 PINK1 FOXO4 DDIT3 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 TSPOAP1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus NEURL1B UBA52 DNER APH1A DLL4 MIB2 ITCH PSENEN DTX1 NCSTN MIB1 DTX2 APH1B NUMB PSEN2 DLK1 NEURL1 ADAM10 CNTN1 PSEN1 UBB UBC RPS27A DTX4 JAG2 JAG1 ADAM17 DLL1 ARRB1 ARRB2 NOTCH1 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis NKX2-5 LEF1 ISL1 CTNNB1 SRF KAT5 FOXO4 SMAD1 SMAD4 HEY1 MEF2C KAT2A HAND2 MESP1 HEY2 GATA6 TBXT TBX20 SMYD1 TBX1 EOMES MYOCD HAND1 LDB1 TBX5 WDR5 GATA4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 SERPINB13 CTSV SOCS3 CTSL CTSK CBFB SOCS4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 APOB S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 GSDMD BIRC3 GSDME USP14 BTRC TLR7 RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 HSP90B1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 LGMN MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB UNC93B1 SIGIRR TLR3 IRAK3 MEF2C CTSS UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 CNPY3 SAA1 TAB3 TLR8 SKP1 TAB2 CTSB TP53 NFKBIB FOS CTSV ELK1 CTSL CTSK MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 ABCB6 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 EGF EGFR NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 TACC3 PSEN1 UBB UBC RPS27A YBX1 JAG2 JAG1 DLL1 NOTCH3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose PMM1 MPI HK1 GMPPB PMM2 GMPPA PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 RBBP4 HLA-DRB5 TRAV19 RBBP5 HLA-DRB4 RBBP7 HLA-DPB1 TRAV8-4 HLA-DRA CDK4 HLA-DRB3 CD4 HLA-DRB1 H2AX HLA-DQB2 H2AB1 HLA-DQB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PTPN11 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 CSK PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 PTPN6 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions CD47 SIRPB1 PTK2B SIRPA FYB1 SIRPG PTPN6 PTK2 SKAP2 TYROBP PTPN11 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFAM TFB2M NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 GNGT1 RHOA GNGT2 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PDPK1 GNG10 AKT1 GNG12 AKT3 GNG11 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ2 KCNJ4 KCNJ14 KCNJ12 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP TXNIP SIRT1 KAT2B SIRT3 FOXO3 FOXO1 EP300 TXN FOXO4 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PALS1 PATJ TJP1 CRB3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 LYN EPO EPOR IRS2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP1 HLA-H PIK3R4 HLA-B SEC13 HLA-C ATG14 HLA-F HLA-G HLA-E BECN1 HSPA5 SEC24D PDIA3 SEC24C TAP2 SAR1B SEC31A TAP1 TAPBP CANX CALR SEC23A B2M HLA-A SEC24B SEC24A ERAP2 PIK3C3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade FRAT2 APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 FRAT1 PPP2R1A PPP2R5E PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 PTK6 STAT3 SOCS3 STAP2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy CETN1 PARK7 UBC RNASE1 GFAP CFTR PLIN3 RPS27A HSP90AA1 HSPA8 UBA52 ARL13B HSP90AB1 HBB HDAC6 PCNT EEF1A1 PLIN2 LAMP2 IFT88 UBB SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome DDX5 ZCRB1 VHL RB1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System KCNJ8 AP2A1 KCNJ11 ABCC8 ABCC9 ADCY9 NTRK3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT RTN3 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 DBNL KCNK6 KCNK7 KCNK1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 GRM1 GRM5 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 FLOT1 FLOT2 ARHGEF9 EPB41L3 GJC1 GJA10 GJD2 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 KCNG1 KCNG2 BCHE KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 PRKCA KCNK17 KCNK18 KCNQ1 KCNQ2 KCNQ3 SNAP25 KCNQ4 RAB3A KCNQ5 SLC32A1 KCNV1 SYT1 SLC6A13 KCNV2 ABAT KCNN1 KCNN3 SLC6A1 KCNN4 CPLX1 RIMS1 KCNF1 KCNC1 ALDH5A1 KCNK9 DNAJC5 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 GIT1 KCNAB1 KCNAB2 KCNAB3 KCNA10 IL1RAPL1 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 HSPA8 KCNK2 VAMP2 KCNK3 HCN2 KCNK4 HCN1 SLITRK3 CAMKK1 CAMKK2 SLITRK5 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 SYT2 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 KCNN2 PTPRF SYN3 SYN2 HRAS SLC6A11 PDPK1 PTPRS ARL6IP5 HOMER3 CACNA2D1 CACNA2D3 EPB41 STXBP1 EPB41L5 NRAS EPB41L2 HOMER1 HOMER2 CHAT PPFIBP1 PPFIBP2 GRIP1 MAPK1 GNAT3 SLC6A4 PANX1 CHRNB2 PANX2 NSF SIPA1L1 CHRNB4 DLGAP1 CHRNB3 GABRG3 DLGAP3 DLGAP2 GRIP2 GABRG2 SLC18A3 DLGAP4 CHRNA1 BEGAIN CHRNA3 SLC17A7 CHRNA2 MAPK3 APBA3 CHRNA5 APBA2 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 SHARPIN GRIK4 LRRC4B GRIK1 SYT9 GRIK2 GRIA1 SYT7 GABRR3 LRRTM3 CAMK2B GABRR2 GRIA2 LRRTM4 GABRR1 LRRTM1 CAMK2D LRRTM2 NPTN SRC ACTN2 HTR3E IL1RAPL2 HTR3C SHANK3 CAMK2A HTR3D NRG1 SHANK2 GRIN2C HTR3A SHANK1 GRIN2B HTR3B NLGN3 PICK1 NRGN NLGN1 GRIN2D GNAI3 NLGN2 AKAP5 GRIN1 NRXN1 GNAI1 DLG1 NRXN3 GRIN2A NRXN2 NCALD GNAI2 DLG2 SLITRK2 CHRND DLG3 SLITRK1 LRRC7 GLRA1 SLITRK4 DLG4 CACNG8 SLITRK6 NEFL GLRA2 PDLIM5 CALM1 GLRA3 NLGN4Y CHRNG CAMK2G NLGN4X SYT10 CHRNE SYT12 CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling JUN NTRK3 NTF3 PDGFB IRAK1 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PDGFRA RAC1 KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 ESR2 HDAC2 SRC NR4A1 NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 GSK3B IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis IRF1 IRF2 CYCS CHMP3 CHMP6 CHMP7 BAK1 ELANE GZMB GSDMD GSDME BAX TP63 IL18 IL1A IL1B CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A HMGB1 TP53 CASP5 CASP1 CASP4 CASP3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein BID BAK1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 POLB LIG3 APEX1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine CTH FMO1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 TST ETHE1 SLC25A10 CDO1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 GCGR GNGT1 GCG GNGT2 GIP GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCYAP1 ADCYAP1R1 GNG10 GNG12 GNG11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TFAP2A CDKN1A TFAP2C MYC DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG3 PPARGC1A MAPK12 PRKAB2 PRKAA2 MAPK14 MAPK11 PRKAG1 PRKAB1 PRKAG2 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 FAM13B WIPF1 WIPF2 CYFIP2 WIPF3 ARHGAP44 PREX2 DOCK11 ARHGDIA NISCH RALBP1 ARHGAP45 SPATA13 ARHGEF25 CIT IQGAP1 PLD1 FGD5 IQGAP2 CHN2 IQGAP3 ARHGAP22 FARP2 ARHGAP20 SRGAP3 SRGAP1 ARHGAP29 ARHGAP27 ARHGAP24 PKN2 ARHGAP33 PKN1 ARHGAP31 FAM13A ARHGAP30 DOCK6 ARHGAP9 DOCK9 DOCK8 DOCK7 WASL ARHGAP4 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARHGAP10 CDC42EP4 TRIO RASGRF2 WAS PLEKHG6 PARD6A CHN1 PAK6 PREX1 SH3BP1 MCF2L PAK3 RAC1 WASF3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 SRGAP2 ARHGEF10 CDC42BPA DEF6 PLEKHG2 KTN1 ARHGEF15 DLC1 PIK3R3 ARHGEF19 PIK3CA DIAPH3 ARHGEF18 ITGB1 VAV1 VAV2 TIAM2 TIAM1 SOS1 ARHGEF4 ARHGEF7 PIK3R2 SOS2 PIK3R1 ARHGEF5 NGEF ARHGEF6 KALRN GNA13 ABR SYDE2 ECT2 ARHGEF39 MCF2 ARHGAP12 PLD2 CDC42 ARHGAP25 ARHGAP23 DOCK5 DOCK4 FMNL1 DOCK3 LAMTOR1 ALS2 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 ARHGAP42 BAIAP2L1 OPHN1 ARHGDIB EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PAK1 RACGAP1 NHS ABL2 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 GIT2 CAV1 MCAM SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 POU2F1 TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP MAPK1 CSTF3 CSTF2 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 SNRPB SRSF9 RBM8A CPSF4 CHTOP CPSF1 ALYREF CPSF3 CPSF2 YBX1 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants FLT3 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC YWHAE YWHAQ YWHAG YWHAH TRAF2 TNFSF10 UNC5A KPNA1 DAPK1 UNC5B DAPK2 DAPK3 FADD BIRC2 CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 E2F1 APPL1 DFFB DFFA DBNL ACIN1 TFDP1 KPNB1 TFDP2 GAS2 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 ARHGAP10 TICAM1 PKP1 LY96 AKT2 BMF BMX STK24 STK26 AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 PPP3R1 TP53BP2 DNM1L DSP OMA1 OCLN OPA1 DSG1 DSG3 TNFRSF10B TNFRSF10A PLEC STAT3 DYNLL1 UACA ADD1 BAK1 GZMB CDKN2A MAGED1 DYNLL2 MAPK1 PPP1R13B MAPK8 CTNNB1 BCL2L11 TJP1 FAS FASLG MAPK3 BAD PMAIP1 CDH1 YWHAB SATB1 PSMD8 PSMD6 PSMD7 PSMD2 CASP6 PSMD3 AKT1 PSMD1 PRKCD APC SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BAX PSMD13 TP63 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC BBC3 BCL2 DSG2 PSMB1 RPS27A BCL2L1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TP73 TP53 PAK2 PTK2 CASP9 CASP7 APAF1 DIABLO AKT3 CASP3 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 CYP2U1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CD36 ITGB5 CYBB CYBA ITGAV INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF28P SCOC SYS1 KDELR1 GOLIM4 KDELR3 GCC2 GCC1 RAB43 RAB41 GOLGA5 KIF5C GOLGA1 ARFIP2 KIF21A KIF21B RHOBTB3 KIFAP3 KLC1 COG8 KLC4 COG7 KLC3 COG6 KLC2 COG5 COG4 COG3 COG2 COG1 RINT1 RAB30 RAB36 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 ARL1 KIF3B SEC22B MAN2A2 VTI1A KIF3C RAB9A RAB6B RAB9B KIF5B RAB39A KIF5A KIF18B KIF4B ALPP KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 M6PR MAN1A2 KIF13B TMED3 VPS45 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 KIF6 BET1L STX5 KIF27 COPZ1 RAB33B KIF9 KIFC2 KIFC1 NAA35 NAA38 VAMP4 PAFAH1B3 ARF5 NAPA GBF1 TGOLN2 NAPB NBAS TMF1 RAB6A STX16 RAB1A STX18 RAB1B GOSR1 NAPG STX10 CYTH3 ARFRP1 CYTH2 GALNT1 CYTH4 CUX1 VPS51 VPS53 VPS52 MAN1C1 SNAP29 BNIP1 ARFGAP3 STX6 ARFGAP2 VPS54 DYNC1LI1 CAPZB CYTH1 RIC1 DYNC1LI2 GALNT2 ARCN1 ZW10 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF MAN2A1 KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 PLIN3 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 IGF2R ACTR1A ARF1 GOLGA4 VAMP3 DCTN2 CAPZA1 DCTN3 GOSR2 RACGAP1 YKT6 ARFGAP1 USP6NL HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 HS6ST1 HS6ST2 HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function JUP PRDM8 CTNND1 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism CSPG4 GUSB ARSB CHST3 CHST14 DSEL DSE UST CHST15 IDUA CHPF NCAN HEXB CHSY1 HEXA CHST11 CHST12 BGN GLB1L3 CHSY3 CHST13 DCN GLB1L2 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b MPI NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors LPAR4 ADORA2B GPR17 P2RY10 P2RY11 LPAR6 ADORA2A P2RY12 P2RY6 P2RY13 P2RY2 P2RY14 P2RY1 P2RY4 ADORA3 ADORA1 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy MAP1LC3A FUNDC1 VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 ULK1 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN CSNK2A1 TOMM40 CSNK2A2 UBE2D2 UBE2D3 CSNK2B MTERF3 PINK1 UBE2N NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes CREBBP GEM ARNT NAMPT CDK5 RBFOX3 INS PLK2 NPAS4 MDM2 IQSEC3 MAPK1 ARNT2 BDNF XPO1 FOS BMAL1 CDK5R1 MAPK3 RET SYT10 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling JAK3 STAT5A STAT5B STAT3 IL9 JAK1 STAT1 IL2RG IL9R SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNA13 GNGT2 GNAT3 PLA2G4A GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 TBXA2R GNG7 AAMP MAPK14 GNA11 GNG8 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 P2RY1 GNG12 GNG11 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 GPRIN1 GRIA2 HDAC1 HDAC2 OPRK1 GRIN2B SIN3A SLC2A3 MET GRIN2A TRPC3 OPRM1 PTPN1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin PIK3CB RAPGEF1 SOS1 STAT5A STAT5B SHC1 PIK3CD LYN PIK3R1 PIK3CG PIK3R5 NRAS PLCG1 HRAS JAK2 GAB1 PLCG2 CRKL PIK3CA EPO VAV1 EPOR IRS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis UBC ENO1 TRIM27 RPS27A RAB7A KPNA1 SFPQ UBA52 ATP6V1H MAPK1 NOS2 CTSG VPS33B DUSP16 CORO1A PGK1 HGS RNF213 RAB5A GSK3A KPNB1 MAPK3 UBB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ACADL HADHA ACADM DECR1 ECI1 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNG13 ARHGEF9 GNB2 GNB1 ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 GNAT3 GABRG3 GABRG2 GABRB3 GABRB2 GABRB1 GNG3 GNG2 GABRR3 GNG5 GABRR2 GNG4 GABRR1 GNG7 NPTN GNG8 GNAI3 GNAI1 GNAI2 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u DPM3 DPM1 DPM2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IQGAP1 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 ADCY8 GNGT1 KCNC2 ADCY6 GCG ADCY5 GNGT2 RAP1A PRKACG PRKACA PRKACB GLP1R RAPGEF3 RAPGEF4 KCNB1 GNG3 ITPR1 KCNS3 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A KCNG2 AKAP5 GNG10 GNG12 GNG11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRA2C ADRA2B ADRB1 ADRA2A ADRA1D ADRB2 ADRB3 ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CREBBP MAFK NFE2L2 EP300 CCL2 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME UGT2B7 ABCB1 UGT1A3 AKR1C1 CYP3A4 HSD11B1 HSD11B2 ALB UGT2B17 SERPINA6 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC TAB3 RPS27A TICAM1 TLR3 TAB2 MAP3K7 TRAF6 UBA52 UBB TAB1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex NEDD4L ITGB8 ITGB5 SERPINE1 PMEPA1 FURIN PARP1 BAMBI STRAP HDAC1 RHOA TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 MAPK1 ITGA8 SKIL PPP1R15A MAPK3 TGFB2 ATP1B4 TGFB3 SKI CDK8 NCOR2 SMAD2 MTMR4 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC SMURF1 TGFBR3 E2F4 FKBP1A CCNT2 PPM1A E2F5 UBE2D3 XPO1 RBL1 TGIF1 STUB1 UBE2D1 TGIF2 TRIM33 CCNK CBL CCNC UBA52 CDKN2B COL1A2 PPP1CA USP15 CCNT1 TFDP1 TFDP2 PPP1CB PPP1CC UBB UBC SP1 UCHL5 RPS27A CDK9 EP300 JUNB PARD6A NEDD8 CGN F11R RNF111 MEN1 PRKCZ WWTR1 PARD3 USP9X LTBP4 ITGB3 ARHGEF18 ITGB1 LTBP3 ITGAV LTBP1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 C4A C3 CFB C4B_2 C2 C5 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 LTC4S PON3 ALOX5AP PON2 PON1 GPX2 GPX1 ALOX5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins FZD2 FZD5 FZD7 WNT5A FZD4 PRICKLE1 FZD1 FZD8 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 SCRIB VANGL2 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PARD6A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 DVL2 PSMC1 PSMC2 FZD3 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance CLTB ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 TYROBP DOCK1 ERBB2 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM ANK1 SEM1 FYN CLTC CLTA AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 MSI1 COL6A2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 ROCK1 ROCK2 CNTN1 DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 YES1 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PDGFB CTSG PRSS2 KLK2 A2M PECAM1 P4HB TIMP1 BMP2 PLG LAMA5 LAMA2 PPIB LAMB3 LAMC3 LAMB2 LAMA1 P4HA1 LAMA4 ELANE P4HA2 LAMA3 FN1 P4HA3 LAMB1 LAMC2 LAMC1 VTN CAPNS1 CAPNS2 CAPN2 CAPN1 BMP7 CAST DAG1 MMP1 MMP2 MMP3 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 FBLN1 LTBP3 FBLN2 LTBP1 FBLN5 LOXL1 LOXL2 COL17A1 EFEMP2 COL15A1 COL16A1 EFEMP1 COL13A1 ITGB8 GDF5 COL14A1 COL11A1 PLEC MFAP5 COL11A2 BMP4 COL12A1 MFAP4 COL19A1 LOX COL10A1 MFAP3 COL28A1 MFAP2 FBN1 COL26A1 COL27A1 COL24A1 COL25A1 ACTN1 NCSTN COL22A1 COL23A1 COL2A1 ADAM10 COL5A1 PSEN1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 SDC4 COL5A2 COL8A2 SDC2 COL20A1 SDC3 COL4A6 COL6A3 COL21A1 COL8A1 COL4A5 COL6A6 COL6A5 NTN4 CDH1 CTSS SDC1 PRKCA KLKB1 COL1A1 COL1A2 ITGA10 PRSS1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 PHYKPL CTRB2 CTRB1 P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 DTNA DTNB SSPN CTSB DDR1 MMP20 MMP24 TPSAB1 MMP13 MMP10 MMP12 MMP11 MMP14 MMP16 CASP3 MMP15 COL18A1 MMP17 MMP19 ITGA3 DDR2 ITGB4 TMPRSS6 ITGA1 DRP2 NID1 DMD NID2 JAM2 ITGA6 FURIN JAM3 PLOD3 PLOD2 PLOD1 SPP1 CAPN8 CAPN9 CAPN6 TGFB1 CAPN7 CAPN5 CAPN3 PCOLCE ADAM15 ADAM12 ADAM9 UTRN CD151 HTRA1 SCUBE3 SNTG2 SCUBE1 CRTAP VCAM1 TRAPPC4 BMP1 ITGA11 COLGALT2 MMP25 ITGAE TIMP2 SGCE SGCD SGCA SGCB ITGB7 COLGALT1 SGCG ADAM17 SNTA1 ITGAD PCOLCE2 SPOCK3 SGCZ CAPN13 NCAN CAPN14 CAPN11 CAPN12 BGN CAPN10 TLL2 DCN TLL1 SNTB1 BCAN CASK SNTB2 VCAN CMA1 ADAM8 ITGAM SH3PXD2A ITGB2 FGF2 TTR F11R CTSD ITGB3 ITGA2B ITGB1 COL3A1 ITGAV COL4A2 NCAM1 COL4A1 ITGA5 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 ITGAL TNXB LRP4 ACAN TGFB2 CEACAM6 LUM CEACAM8 TGFB3 CD47 DSPP COL9A1 CD44 ITGA4 COL9A3 COL9A2 AGRN FMOD ADAMTS4 ADAMTS5 NRXN1 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 KDR ADAMTS9 THBS1 ADAMTS16 ADAMTS14 ADAM19 FGB ADAMTS18 FGA MMP8 FGG MMP9 PDGFA CEACAM1 PXDN BSG CTSV CTSL MMP7 CTSK TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling XIAP TRAF2 FADD USP4 BIRC2 USP2 BIRC3 MIB2 CYLD RBCK1 OTUD7B RIPK1 USP21 SHARPIN TNF TBK1 OPTN TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 NEK2 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 COPS5 PSMD3 PSMD1 GSK3B CUL1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT2 GPAM PLA2G4A PLA2G2A RAB5A PIP4K2A PIP4K2B LIPI PIP4K2C LIPH BMX STARD7 RUFY1 PLBD1 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 PTPMT1 PIP5K1A PIP5K1B CHKB CHKA STARD10 ARF3 ACHE MTMR14 LPCAT1 OSBPL10 GNPAT PIP4P1 GPAT4 GPAT3 CEPT1 BCHE AGK LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 LCLAT1 PIP5K1C PCYT2 PGP PLA2R1 INPP5D ABHD4 PIK3CG PIK3R6 ABHD3 PIK3R5 ARF1 OSBPL8 RAB4A OSBPL5 OCRL SYNJ2 SYNJ1 PIK3CD PIK3C2G PIK3C2B ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B TPTE AWAT2 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 RAB14 LPGAT1 PITPNB CPNE7 CPNE6 GDE1 CPNE1 CPNE3 MFSD2A SACM1L PISD PLA1A PGS1 PTDSS2 PTDSS1 INPP5J INPP5K TMEM86B PTEN MTMR1 PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 GDPD1 GDPD3 GDPD5 PIK3CB PNPLA7 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 ETNPPL PLEKHA8 PNPLA3 PNPLA6 PTPN13 INPPL1 PLB1 ENPP6 PIK3R3 SBF1 PIK3CA SBF2 TPTE2 PIK3C3 MIGA2 MIGA1 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 INPP5E CHAT PLD4 PLD6 PLD3 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 PI4KA VAC14 PI4K2B PLD2 MTMR10 ALPI MTMR2 GPD2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A PCTP LPIN1 FIG4 LPIN2 INPP4B MGLL PLA2G4F PIKFYVE LPIN3 INPP5F PI4K2A PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 AGPAT5 PLA2G1B AGPAT1 SELENOI AGPAT3 AGPAT4 PLA2G2F PLA2G2D PLA2G2E CHPT1 GPD1L CDS1 PITPNM1 PITPNM3 PNPLA2 PITPNM2 CDIPT SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC MRE11 NLRC3 IFI16 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions ITGA10 CHL1 ITGA2 ITGA1 ANK1 CNTN6 HSPA8 NRP1 ITGB1 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKAR2A PRKACG PPP3CB AKAP5 PRKACA PRKACB OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF QRFPR HCRTR1 QRFP NPFFR2 HCRT NPFFR1 HCRTR2 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis RXRA NR1H2 NR1H3 RXRB NCOR2 NCOR1 UGT1A3 FABP6 NCOA1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks RAD50 MRE11 KPNA2 ATM KAT5 NBN MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR5AL1 OR8H3 OR8H2 OR8H1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 KCNMA1 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 SLC17A8 OR2A25 OR51I2 ITPR3 TAS2R30 TAS2R31 LRP8 OR10S1 TAS2R38 KCNMB1 OR52K2 OR51I1 TAS2R39 OR52K1 CNGA2 APOB RPE65 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 ATP2B1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 TAS2R50 OR4D1 OR5F1 OR10Z1 NMT1 OR52R1 OR4C6 OR4C5 OR3A3 SPTAN1 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 HSD17B6 OR4C45 OR5AN1 OR4B1 OR4C46 GSN OR8J3 OR6F1 OR8J2 FNTA OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 PRKCQ OR5H14 OR2D3 OR52A4P CYP4V2 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 CALHM1 OR6K2 CALHM3 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 CAPZA2 OR5H6 OR4F5 OR2B3 SDC4 OR4F4 OR2B2 SDC2 OR10K2 SDC3 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 GPC1 OR51A7 OR2A2 GPC3 TAS2R7 GPC2 OR52J3 GPC5 RTP2 GPC4 OR51H1 TAS2R8 GPC6 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 SDC1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 OR51G2 OR51G1 OR52I2 SNAP25 OR52I1 RAB3A OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 DNAJC5 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 MSN OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 CAPZA1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LRP2 AWAT2 GNG13 GNB1 GNB3 GNGT1 RDH5 RLBP1 HSD17B1 CAPZB AKR1C1 TTR AKR1C4 PLB1 SPTBN1 CALM1 RDH11 RDH10 RDH16 AKR1C3 DHRS3 DHRS9 APOA2 APOA1 APOA4 LPL LDLR GPIHBP1 APOC3 TRPM5 TRPM4 MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 GRM1 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B PLCB2 MYO3A FSCN2 EZR TWF2 PCDH15 PDE6B CABP2 PDE6A USH1C CACNA1D CABP1 LRRC52 ESPNL PDE6G EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 LHX2 STX1A SCN1B OTOF SCN3A SCN2A SCN2B PRKCA KCNQ4 SCN9A SCN4B VAMP2 ABCA4 SCNN1G SCNN1D SCNN1B SCNN1A RBP4 RDH12 OPN1LW RBP1 LRAT STRA6 OPN1MW CASK OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 GUCY2D OR2AE1 GUCA1B OR11H6 GUCA1A OR11H7 GUCA1C OR2L8 GUCY2F OR1J4 GRK1 OR2L5 GRK7 OR11G2 FNTB OR1J2 RHO OR2L3 CNGA1 GNAT1 OR4P4 OR1J1 RCVRN OR2L2 CAMKMT OR10AD1 RGS9BP OR6T1 SAG OR4K15 NMT2 RBP3 PPEF1 OR4K14 METAP1 OR4K13 METAP2 OR13J1 CNGB1 OR7A2P CHRNA9 OR2K2 CHRNA10 OR1I1 KCNN2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 GNAT3 OR1L1 OR5T3 HSPG2 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOE OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P EPB41L1 OR5AS1 OR2T8 OR2T7 OR2T6 AGRN OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 APOC2 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 KCNJ2 OPN1SW OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 LRP1 RETSAT OR6C74 OR14I1 APOM OR10A7 OR56A5 BCO2 OR7A5 BCO1 OR10A2 OR56A4 AKR1B10 CLPS OR10A4 RBP2 OR56A3 SLC24A1 OR10A3 LRP10 OR10A6 LRP12 OR56A1 PNLIP OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL SRC YWHAB HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex XIAP SOX17 APC SRY YWHAZ SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 TCF7L2 PYGO1 BCL9 TCF7L1 PYGO2 HDAC1 UBA52 LEF1 TCF7 TLE4 TLE2 TLE1 BTRC RBBP5 CTNNB1 CTBP1 UBB UBC ASH2L RPS27A KMT2B SOX2 AKT2 MEN1 SOX9 TLE3 XPO1 DPY30 WDR5 AKT1 CHD8 CBY1 SOX3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CDK1 CCNB2 CLIP1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN JMJD6 RIOX2 BGLAP EIF5A DHPS FN3KRP EIF5A2 FN3K ICMT DOHH RPL8 STS RWDD1 JMJD4 KDM8 JMJD7 ARSA ETF1 RIOX1 OGFOD1 SUMF2 SUMF1 DRG1 DRG2 RCCD1 ZC3H15 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD F8 RPL27A ARSB ASPH U2AF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 RPS6 DPH6 DPH7 EEF2 F7 F9 PROC F10 TPST2 GGCX PROS1 TPST1 PROZ F2 GAS6 RPS23 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 CD209 BTN3A2 BTNL2 PPL XDH INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals MT1G MT1H MT1X MT4 MT1B MT3 MT1E MT2A MT1A MT1M MT1F GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib SLC37A4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib ERBIN HSP90AA1 ERBB2 CDC37 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 RASGRP2 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A RARRES2 IGF2 RAF1 RAB27B IGF1 PPBP RAPGEF3 CYRIB MANF RAPGEF4 SELP TF SCCPDH CALU MAGED2 PLA2G4A HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 ITPR1 CTSW ITPR2 ORM2 ITPR3 SERPINA4 TMSB4X PSAP ALB PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 TRPC7 ABCC4 AHSG ANXA5 F5 TRPC6 PLCG2 F8 TRPC3 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 CRK LEFTY2 LY6G6F LHFPL2 PCYOX1L CD9 FLNA FN1 F2RL2 F2RL3 LCP2 F2R LAT PRKCB RAC1 VAV3 PRKCQ P2RY12 P2RY1 VAV1 VAV2 MPL THPO ACTN1 GNA13 ADRA2C ADRA2B ADRA2A TBXA2R AKT1 GP1BB PRKCD PRKCA GP5 YWHAZ GP9 LYN PIK3CG PIK3R6 PIK3R5 GP6 CFL1 PF4 SOD1 AAMP MAPK14 PPIA TUBA4A PRKCG PRKCE GNG10 GNG12 GNG11 GNG13 GNB2 CFD GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TGFB1 GNGT2 GNA14 GNG3 GNA15 PDPN MPIG6B GNG2 CLEC1B GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 EGF PIK3CB PFN1 PRKCZ BCAR1 PCDH7 PDPK1 PIK3R3 PIK3CA ITGB3 ITGA2B SOS1 BRPF3 SPARC RAC2 SHC1 SERPINE1 RHOG PIK3R2 PIK3R1 GP1BA RHOA RHOB MAPK1 GNAT3 FCER1G MAPK3 PTPN1 TGFB2 PTPN11 TGFB3 CDC42 MGLL DGKG SRC ACTN2 DGKE DAGLA DGKD DGKB DGKA ABHD6 GNAI3 ABHD12 PRKCH GNAI1 DGKZ DGKQ GNAI2 DAGLB DGKK DGKI DGKH CALM1 CD36 VEGFB VEGFC VEGFD THBS1 VEGFA ALDOA GNA12 CSK FGB FGA VWF FGG APBB1IP TLN1 VCL PTPN6 SYK LCK FYN APP F13A1 POTEKP ISLR LAMP2 HABP4 PROS1 FAM3C CHID1 F2 PTK2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 TREX1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction KCNJ11 ABCC9 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 GUCY1A2 GUCY1A1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MME ATP2B4 NPR1 ATP2B3 NPR2 ATP2B2 NPPC ATP2B1 CORIN TRPC1 CES1 SLC8A3 TTN ANXA1 PXN KCNK6 KCNK7 KCNK1 MYL12B CACNA2D2 MYL6 MYH11 CACNB2 NKX2-5 SCN11A SCN10A TMOD3 SCN1B SCN1A MYL9 KCNH2 SCN3B SCN3A KCNK10 GATA4 KCNK13 SCN2A KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 SCN9A KCNK9 SCN8A CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A ANXA2 KCNA5 SCN4A SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 TRIM72 PAK1 DYSF LMOD1 AHCYL1 MYL6B CACNA1H MYL12A MYLK CACNA1G CACNA1I ALDH2 PAK2 CALD1 ANXA6 MYL10 CAV3 TPM2 MYL11 TPM1 SORBS1 SORBS3 MYL5 MYL7 ITGA1 DMD SLN ATP1B3 ATP1B2 ATP1B1 PDE5A VIM ACTN3 KCNK12 KCNK15 FXYD4 MYL4 FXYD3 MYL1 MYL2 FXYD2 MYL3 DMPK FXYD1 MYBPC3 FXYD7 MYBPC1 FXYD6 MYBPC2 TNNC1 RYR1 TNNC2 RYR2 TNNT1 RYR3 TNNT2 TNNT3 TCAP CLIC2 TMOD1 TMOD4 TMOD2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 MYH3 MYH8 MYH6 ATP1A4 CACNG6 ATP1A3 CACNG7 TNNI1 ATP1A2 TNNI2 TNNI3 ATP1A1 KCNIP1 TPM4 KCNIP2 KCNIP4 TPM3 DES RANGRF PLN KCNIP3 FKBP1B ITGB5 CACNB1 CAMK2B CAMK2D ACTN2 CAMK2A TBX5 CACNG8 CALM1 CAMK2G CACNG4 KCNJ2 KCNJ4 KCNJ12 TLN1 VCL WWTR1 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A TCEA1 ERCC8 DDB1 XPA COPS7B COPS7A CUL4A COPS3 PPIE COPS6 COPS5 COPS8 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication ORC4 ORC6 H2BC9 ORC1 H2AZ2 ORC3 H4C9 ORC2 H2BC8 H2BC5 H2BC3 KPNA1 H2BC1 H2AC20 KPNB1 H2AX H2AB1 H2AC19 KPNA6 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ORC5 H3C15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT SOX17 XIAP SRY RNF146 SOX6 WNT5A SOX7 SOX4 WNT1 BCL9L RUVBL1 CTNNBIP1 FZD1 SOX13 RYK USP8 PYGO1 FZD8 BCL9 PYGO2 TLE4 TLE2 TLE1 CUL3 TNKS SMURF2 USP34 DPY30 WDR5 AXIN2 BTRC RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 KLHL12 LGR6 WNT3 LGR5 CCDC88C RSPO4 DACT1 LGR4 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 EP300 SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 PPP2R5E H3C15 FRAT2 FZD2 FZD5 H2BC9 FZD4 H2AZ2 H4C9 FZD6 PPP2R5B H2BC8 PPP2R5A H2BC5 PPP2R5D H2BC3 PPP2R5C H3-4 TCF7L2 H2BC1 TCF7L1 HDAC1 H2AC20 LEF1 TCF7 PIP5K1B CTNNB1 PPP2CA PPP2CB ASH2L MYC RSPO3 TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 APC YWHAZ PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 CSNK1G2 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 LEO1 WNT3A LRP5 PSMA7 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 KAT5 LRP6 PSMB4 DKK4 SFRP1 CTBP1 PSMB5 CSNK1E SFRP2 UBB WIF1 SOST PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A TERT ADRM1 MEN1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 WNT4 SMARCA4 PSMC1 CSNK2B PSMC2 TLE3 CHD8 CAV1 CBY1 SOX3 TRANSLATION%REACTOME%R-HSA-72766.7 Translation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 APEH HEMK2 MRPS18B MRPS18A ETF1 GSPT2 MRPS21 GSPT1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 TUFM MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 RARS1 EIF2B5 MRPL30 EIF2B4 EIF2B3 MTRES1 LARS1 EIF2B2 MTRFR NDUFAB1 EIF2B1 AIMP1 AIMP2 RPS4Y2 QARS1 RPS27L RPS4Y1 RPS4X MARS1 RPS15 RPS14 DARS1 RPS17 SARS1 EEF1E1 RPS15A RPS16 RPS19 KARS1 RPS18 RPS3 IARS1 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPN2 ASCC2 RPN1 ASCC3 EIF2S2 EIF2S1 DDOST MT-CO1 EIF2S3 EPRS1 EIF4EBP1 EIF4E EIF4B TRMT112 EIF1AX UBE2D2 EIF4H PSMD8 UBE2D3 EIF3M PSMD6 EIF3K MT-CO2 EIF3L PSMD7 MT-CO3 ELOB EIF3I ELOC EIF3J PSMD2 RBX1 EIF3G EIF3H PSMD3 EIF3E CUL2 EIF3F PSMD1 EIF3C EIF3D EIF3A EIF3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 LTN1 NPLOC4 PSMD12 SEC61G PSMD11 RPLP0 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SSR1 PSMC2 EIF4G1 SRPRA SRPRB MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 SEC61A2 SPCS3 SEC61A1 SPCS2 VCP SPCS1 SEC11A SEC11C MT-ATP6 MT-ATP8 MT-ND4L PARS2 EARS2 LARS2 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 EIF4A2 TCF25 SRP54 EIF4A1 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 MT-CYB SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 CARS2 VARS2 ANKZF1 KLHDC10 TSFM RPL4 EIF5B RPL5 MARS2 RPL30 DARS2 RPL3 EEF1G RPL32 SARS2 RPL31 NEMF RPLP1 EEF1D RPL34 MTRF1L RPL10L EEF1A1P5 RPL8 MTIF2 RPL10A MTIF3 RPL6 IARS2 RPL7 WARS1 RPL7A WARS2 RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 SRP14 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBE2D1 SEM1 EEF2 MRPS17 MRPS15 MRPS16 MRPS14 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2B GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 GRIA3 CAMK2G GRIA4 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO2 SLIT1 NCK2 ROBO1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism PLCB4 MTMR9 INPP5D MTMR7 PLCG1 PLD4 IPPK ISYNA1 IPMK OCRL INPP1 IP6K1 NUDT3 IP6K2 NUDT4 INPP5B SYNJ1 NUDT11 NUDT10 INPP5A IMPA1 PPIP5K1 PLCZ1 IMPA2 INPP4A PPIP5K2 INPP5J PLCE1 INPP4B IP6K3 MIOX ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers JUN SEL1L FZD8 ERLIN2 NPM1 KLC1 MAMLD1 IHH DERL2 TRAK1 ERLEC1 OS9 KIF5B PRR5 GSK3A EML4 KRAS MAML2 MAML1 FGFR2 JUNB RAC1 MAML3 VAV1 MAPKAP1 DUSP6 DUSP7 GZMB DCTN1 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 MAPK8 BCL2L11 PAPSS1 BAD CD19 SQSTM1 AGK RBX1 POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F PIK3CG POLR2G POLR2H PIK3R6 POLR2I PIK3R5 POLR2J POLR2K POLR2L WDR48 GTF2F1 GTF2F2 IL10 PTPN12 MSN TYK2 KAT2B PIK3CD KAT2A ALK LMNA TP53 VCP TNKS FOXO4 FOXM1 CDK8 SMAD2 SMAD4 SMAD3 ESR1 JAG2 ADAM17 MDM2 ZMYM2 PTEN ARRB1 ARRB2 TPR HDAC5 RANBP2 FGFR3 HDAC8 HDAC9 HDAC6 HDAC7 TPM4 RNF43 TPM3 KLB FLT3 IRS1 PPP1CC PPP2R1B IRS2 PPP2R1A PIK3CB TNKS2 PPM1B FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 HDAC10 FGF9 HDAC11 AKT2 HRAS PDPK1 GAB1 FLT3LG TWIST1 FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 CARS1 PIK3R1 NRAS FGF20 PPFIBP1 MAPK1 EEF1G FGF23 CHUK FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 SNW1 CAMK2B ESR2 CAMK2D SRC NR4A1 CAMK2A NRG1 TFG MPRIP FGFR1OP2 ZAP70 SND1 ZC3HAV1 EIF2AK3 NOX4 CALM1 ATIC CAMK2G DUSP8 DUSP9 MRAS FAM114A2 KDR PORCN MCL1 CD86 QKI CD80 NF1 KIAA1549 ERBB2 DUSP10 CCNB1 HES1 ESRP1 TRAT1 BIRC6 RPS6KB2 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 PHB1 AGTRAP ARAF AP3B1 SHOC2 PEBP1 CSK AGGF1 JAK2 CPSF6 MARK3 TENT4A SPRED3 FGB BRAP SPRED2 SPRED1 FGA VWF MYO18A KSR1 LRRFIP1 KANK1 PPP1CB FGG RRBP1 BRAF ETV6 WDCP KSR2 GOLGA4 FAM131B BIN2 CNKSR2 STRN APBB1IP CNKSR1 NCBP1 TLN1 NCBP2 VCL FRS3 JAG1 LCK SEM1 IRF4 DLL1 FYN BCL2A1 SKP1 HGF CLIP1 CUL1 CLTC GCC2 NTRK3 NTF3 PDGFB NEURL1B HES5 MIB2 RAP1B MIB1 HEYL RAP1A NEURL1 RAF1 PRF1 ICOS STAT5A IL10RA ZC3HC1 FIP1L1 FN1 CUX1 TRIP11 RPS6 PDGFRA PRKAR1A MYH9 KIT NOTCH1 FZD5 FZD4 HBEGF FZD6 TCF7L2 CDKN1A HDAC1 CTNNB1 MET CEBPB RNF213 ATG7 SEC31A RBPJ TNRC6C MOV10 MLST8 AGO3 AGO4 MYC AGO1 AGO2 TSC2 PIM1 MTOR YWHAB FKBP1A PSMD8 PSMD6 PSMD7 PSMD2 AKT1S1 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 PSMB5 UBB BCR PSMB2 PSMB3 LMO7 UBC PSMB1 RPS27A AKAP9 HEY1 HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CASP9 ERBIN CEP43 KDM7A TGFB1 RICTOR TGFBR1 TGFBR2 STAT1 CD28 IQGAP1 HSP90AA1 EGF CBL EGFR CDC37 PLCG1 RB1 CDKN1B MAP3K11 DUSP16 FGFR1 CLCN6 FOXO6 FOXO1 EP300 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 ITGA2B NRG2 STAT3 HDAC3 TBL1X NCOR2 NCOR1 TBL1XR1 HDAC4 HDAC2 PIK3AP1 AMER1 GSK3B CSNK1A1 AXIN1 APC STAT5B CCNC GRB2 HHAT SHH DHH CTBP2 CTBP1 DNMT1 CREBBP AREG BCL2L1 PTPN6 MAPK9 YES1 NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 EREG SYVN1 BTC EPGN AKT3 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP PPHLN1 H2AC20 MPHOSPH8 H2AX ZCCHC8 EHMT2 EHMT1 H2AB1 TASOR MTREX H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B RBM7 H3C8 MORC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SETDB1 H3C15 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK10 MAPK8 FOS MAPK3 MAPK9 MAPK14 ATF2 MAPK11 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 ALOX5 LTA4H DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 NEIL1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 C2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress GNG13 ITGA5 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 PIK3R2 GNB3 ADCY4 NFKB1 ADCY3 GNB5 ADCY2 ADCY1 ABL1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB CHUK STAT1 PTPN1 IKBKB PPP2CA PECAM1 MLST8 GNG3 GNG2 GNG5 NFKBIA GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 IKBKE AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 IKBKG PPP2R1B ANXA2 PPP2R1A PIK3CB CALCRL ADM TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PTK2 PIK3CA P2RY2 ITGB3 ITGB1 MMP14 GNG12 ITGAV MAPKAP1 GNG11 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor F8 VWF MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2A POLR2B BCDIN3D POLR2C XPO5 POLR2D AGO3 PRKRA POLR2E DROSHA RAN DICER1 AGO4 POLR2F TARBP2 POLR2G POLR2H AGO1 POLR2I AGO2 POLR2J POLR2K POLR2L DGCR8 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly HSP90AA1 IPO5 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis RXRA CYCS SAMM50 HDAC3 MTX1 APOOL NR1D1 CHCHD3 DMAC2L TBL1X NCOA1 ESRRA PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 MT-ATP6 PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 MAPK12 HCFC1 CALM1 ATP5PF ATP5PD PPARGC1A ATP5PB NCOA2 PPARGC1B ATP5F1C NCOA6 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 NRF1 ATP5PO GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HSPA9 HELZ2 ATP5MC2 CREBBP CHD9 ATP5MC3 ALAS1 ATP5MK ATP5MJ MICOS13 MICOS10 CHCHD6 MTERF1 ATP5MG MAPK14 GABPA MED1 MAPK11 SIRT5 TGS1 ATP5MF PPRC1 MEF2D ATP5ME PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 ATP5F1A IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 MTX2 PPARA ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion PRKCA CHRM3 GNA14 GNAQ MARCKS GNA15 PLCB3 PLCB1 PLCB2 GNA11 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors MEF2C RBFOX1 PPARG RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 H2BC15 TP53 H2BC11 ATM UBE2N MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase SHQ1 ACD DKC1 TINF2 TERF1 RUVBL2 TERF2 RUVBL1 TERT NHP2 ANKRD28 POT1 NOP10 TERF2IP WRAP53 PPP6C PPP6R3 RTEL1 CDK2 CCNA2 CCNA1 PIF1 GAR1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RIPK1 CASP10 MAVS FADD RNF135 RIGI CHUK IFIH1 CASP8 TRIM25 TRIM4 IKBKG CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions CDH24 CTNNB1 CDH11 JUP CTNND1 CDH8 CTNNA1 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 FCN1 MASP1 FCN2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway TALDO1 PGD DERA TKT RPIA PRPS2 PRPS1 RPEL1 RPE SHPK PGLS PRPS1L1 RBKS G6PD PGM2 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 FLRT1 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 GIPC1 ANOS1 MAPK1 FLRT3 FGF23 FGF22 SPRED2 SPRED1 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FRS3 FGF3 RPS27A FGF4 FGF6 FGF9 TGFBR3 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 SEL1L PSMA3 CFTR PSMA4 PSMA1 PSMA2 ERLIN1 ERLIN2 UBA52 PSMD12 PSMD11 RNF185 PSMD14 PSMD13 PSMA7 PSMB6 VCP PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 DERL3 DERL1 UBC DERL2 PSMB1 RNF5 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein PRMT1 UBE2I SRPK1 SUMO1 PARP10 SRPK2 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 CSNK1A1 PARP14 PARP8 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB RIPK1 UBC TICAM2 UBE2D1 TICAM1 RPS27A UBE2V1 LY96 TRAF6 UBA52 BIRC2 CD14 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB TLR4 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON GRK2 IHH ARRB1 SHH DHH ARRB2 SMO KIF3A CSNK1A1 PTCH1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress COX5B COX5A RELA NUDT2 PRDX3 NOX5 NQO1 GSTA3 COX6C GSTA1 ERO1A SESN1 SRXN1 CHD6 GPX3 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB COX6A1 BLVRA CCL2 ABCF2 COX6A2 TXNRD2 SOD3 CCS G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM ALB P4HB AQP8 CAT BTRC SOD2 CARM1 ATOX1 FBXL17 BACH1 PRKCI SLC7A11 MED1 NOTCH1 PRDX2 PRDX1 PTK6 CDKN1A CDKN2A SIN3A PRKAA2 MT-CO1 SQSTM1 ATF4 TKT MYC PSMD8 KEAP1 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 PSMD2 RBX1 PSMD3 AKT1 PSMD1 IDH1 PRKCD NCF1 PSMA5 NCF2 PSMA6 NCF4 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 NPLOC4 PSMD12 PSMD11 UBXN7 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CYBB PSMB4 CYBA DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 TALDO1 UBC PSMB1 RPS27A SOD1 ADRM1 CSNK2A1 PSMC5 GPX1 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PPARA CYCS MAFG PGD MUL1 CUL3 VCP PRDX6 NLRP3 TRIM21 GSTP1 HBA2 SESN2 HMOX2 GPX2 MAP1LC3B EGF SMARCD3 SKP2 TXNRD1 EP300 AKT2 STAP2 COX7A2L TXN RXRA STAT3 NFKB1 ABCG2 HBB HDAC3 COX4I1 COX4I2 TBL1X NCOA1 FABP1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 ABCC3 ABCC1 HM13 EIF2AK3 AMER1 NOX4 GSK3B NCOA2 NCOA6 ME1 TXN2 BRCA1 HELZ2 CREBBP SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 PALB2 TGS1 SEM1 COX7B SKP1 COX7C COX8A COX8C CUL1 AKT3 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 BCL11B SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 PHF10 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 BICRAL BRD7 BICRA BRD9 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 DPF1 HDAC2 DPF2 KAT8 DPF3 KDM5B SUZ12 KAT14 SETDB1 SS18L1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SS18 SMARCB1 BCL11A AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 KDM6A DNMT3A PBRM1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 AP2M1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA CSTF2T CLP1 ZNF473 SNRPD3 FIP1L1 SNRPB PABPN1 CPSF4 SLBP CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 CSTF2 CPSF2 CSTF1 PAPOLA SYMPK LSM10 NCBP1 LSM11 NCBP2 PCF11 SNRPG WDR33 SNRPE SNRPF TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR GCHFR GCH1 SPR NOS3 PTS HSP90AA1 PRKG2 AKT1 CALM1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion FES PLXNA2 PLXNA3 HSP90AA1 HSP90AB1 PAK1 PAK3 LIMK1 RAC1 FYN CFL1 PLXNA4 PAK2 NRP1 PLXNA1 SEMA3A CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAH YWHAZ WEE1 SFN CCNB1 CDC25C CDK1 YWHAB CHEK2 YWHAE CCNA2 CCNA1 YWHAQ CHEK1 YWHAG TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN TIMP1 NCSTN APH1B PSEN2 TIMP2 PSEN1 TGFBR3 APH1A MMP14 MMP16 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP5 GP9 VWF GP1BA GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 FABP6 MGLL PLIN1 PPP1CA ABHD5 FABP12 PRKACG PRKACA LIPE PRKACB FABP9 PPP1CB FABP1 PPP1CC CAV1 FABP2 FABP3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling IL21R JAK3 STAT5A STAT5B STAT4 STAT3 JAK1 STAT1 IL2RG IL21 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine CBS CTH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly PET100 COX5B COX5A COA5 CMC1 SCO1 COX6C TACO1 SMIM20 COX4I1 COX4I2 SURF1 COX6A1 COX6A2 COX16 TIMM21 COX15 MT-CO1 COX18 COX6B2 HIGD1A COX6B1 COXFA4 COX7A2 COX7A1 COX11 COX19 COX17 COX14 RAB5IF COQ10B COQ10A TMEM177 COA3 SCO2 COA1 COX7A2L MT-CO2 COX7B MT-CO3 COX7C HIGD2A PET117 COX8A COX20 COX8C TMEM223 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM RTEL1 MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PIK3R1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 CD19 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CD22 TRPC1 IGKV2D-40 PIK3AP1 IGHV3-11 IGHV3-13 IGLV7-43 CALM1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 BTK IGLC3 BLNK IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 PIK3CD IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PTPN6 SYK AHCYL1 FYN VAV1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB P4HA1 P4HA2 P4HA3 COL1A1 COL1A2 ADAMTS14 P3H2 P3H1 P3H3 SERPINH1 COL3A1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC9 H2AZ2 H4C9 H2BC8 NCOA2 H2BC5 H2BC3 H2BC1 H2AC20 PKN1 KDM1A H2AX KLK3 KLK2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B KDM4C H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 AR KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling CASP10 FAS CASP8 FASLG FADD SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins DNMT1 BMI1 RING1 UBE2I SUMO1 RNF2 DNMT3B CBX8 PHC2 PHC1 DNMT3A CBX4 PCGF2 CBX2 PHC3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FRS2 KLB PTPN11 FGF16 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus CLP1 POP5 POP7 POP1 RPP30 POP4 RTCB CPSF4 TSEN2 TSEN54 CPSF1 RPP38 CSTF2 RPP21 RPP25 DDX1 C2orf49 RPP40 TSEN15 ZBTB8OS TSEN34 NUP205 POM121 RPP14 NUP107 NUP188 RTRAF AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 XPOT NUP88 FAM98B NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ELAC2 TRNT1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) UBC DERL2 SEL1L RNF5 RPS27A OS9 MAN1B1 UBA52 RNF185 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 EDEM2 AMFR SYVN1 RNF103 UBB TRIM13 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1 OXCT2 ACAT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis GPI ENO1 ENO2 ENO3 ENO4 G6PC1 TPI1 PGAM1 PC PGAM2 ALDOC ALDOB ALDOA GAPDH PCK2 PGK1 SLC37A1 PGK2 G6PC2 PCK1 G6PC3 FBP1 FBP2 SLC37A4 GAPDHS CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SESN1 SESN2 SEC13 RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X RPS15 SAMTOR RPS14 SEH1L RPS17 NPRL2 NPRL3 RPS15A RPS16 GCN1 TCIRG1 RPS19 WDR59 RPS18 EIF2AK4 FLCN RPS3 MIOS RPS2 RPS11 ITFG2 IMPACT RPS10 DEPDC5 RPS13 KPTN RPS12 WDR24 RPS9 SH3BP4 RPS7 FNIP1 ATP6V1E1 RPS8 FNIP2 RPS5 KICS2 ATP6V1E2 RPS6 CASTOR1 RPSA CASTOR2 ATP6V1G1 RPS3A RPS26 ATP6V0B ATP6V0E1 ATP6V1G2 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ATP6V1B2 TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A RPL4 RPL5 ATP6V1H RPL30 RPL3 RPL32 ATP6V0E2 RPL31 ATP6V1G3 RPLP1 RPL34 ATP6V1D RPL10L RPL8 ATP6V1C1 RPL10A ATP6V1F CEBPB RPL6 ATP6V1C2 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPTOR RPL37 ATF3 ATF4 RPL39 RPL21 MLST8 RPL23 SLC38A9 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 MTOR RPL10 RPL12 RRAGA RPL11 RRAGC RPL36A RPL14 RHEB RPL13 RRAGB RPL15 RRAGD RPL18 RPL17 RPL19 LAMTOR2 RPL39L LAMTOR1 RPL41 LAMTOR4 RPL35A LAMTOR3 RPL23A LAMTOR5 RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism CHST2 B4GALT4 CHST3 B3GNT3 GNS ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 GALNS FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 HEXB HEXA B4GALT2 GLB1L3 B4GALT3 PRELP GLB1L2 CHST6 OMD KERA GLB1L B3GNT7 GLB1 B3GNT4 OGN CHST1 B3GNT2 CHST5 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway XIAP RACK1 TRAF1 TRAF2 MAP3K7 USP4 BIRC2 USP2 BIRC3 CYLD RBCK1 OTUD7B CHUK IKBKG IKBKB RIPK1 USP21 SHARPIN TNF OPTN TAB1 TRADD TAB3 TNFAIP3 TAB2 RNF31 SPATA2 TNFRSF1A OTUD1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 TGFB1 CCL11 CCL2 STAT1 VCAM1 VIM CCL22 BCL6 IL6 TIMP1 RORC RORA NOS2 POU2F1 IL17F IL17A ANXA1 LBP LAMA5 HSP90AA1 FN1 S1PR1 JAK3 IL18 IL1A ITGAM IL1B ITGB2 LCN2 MMP1 MMP2 FGF2 TNFRSF1B FOXO1 IL6R JUNB SOCS3 SOX2 MAOA MMP3 TWIST1 HSP90B1 ITGB1 IL23R IL13RA2 IGHG4 IL13RA1 IGHG1 IL4R STAT3 IL23A FSCN1 PIK3R1 CDKN1A NDN LIF RHOU NANOG ALOX15 IGHE ITGAX OPRD1 OSM BATF CCND1 BIRC5 FASLG SOCS1 FCER2 MYC PTGS2 PIM1 ALOX5 HMOX1 AKT1 HIF1A OPRM1 CD36 MCL1 GATA3 VEGFA POMC COL1A2 IL4 JAK2 MUC1 IL12B IL12A IL13 JAK1 IL2RG IL10 MMP9 SOCS5 BCL2 TYK2 TNF BCL2L1 HSPA8 ICAM1 ZEB1 CEBPD IRF4 STAT6 F13A1 SAA1 TP53 FOS FOXO3 HGF SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN NTRK1 RIT1 NGF RIT2 BRAF VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis NUP85 TPR NUP62 POLR2A POLR2B NUP88 POLR2C NUP43 POLR2D RAE1 POLR2E POLR2F NDC1 POLR2G RANBP2 POLR2H SEC13 POLR2I NUP155 POLR2J NUP133 POLR2K NUP210 POLR2L NUP153 NUP93 NUP50 NUP35 NUP54 GTF2F1 GTF2F2 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids GGPS1 CYP51A1 SRD5A3 LSS SREBF2 SQLE MTF1 DHCR7 SLCO1B1 SLCO1B3 LDLRAP1 CUBN ACACB GPAM STS SLC51A SLC51B CYP27A1 SAR1B CYP39A1 PLPP6 LHB ABCB11 SEC23A MBTPS1 SCAP VDR ALB SLC10A1 MBTPS2 SLC10A2 STAR AKR1B15 SEC24B SEC24A AKR1B1 ARV1 CYP17A1 SMARCD3 STARD3NL SEC24D CYP7B1 SEC24C AKR1D1 CARM1 KPNB1 HSD17B7 CYP7A1 HSD17B1 HSD17B2 HSD17B3 HSD17B12 AKR1C1 NSDHL AKR1C2 ACACA FDXR MED1 AKR1C4 STARD3 STARD4 CYP8B1 STARD5 STARD6 MSMO1 CH25H CYP46A1 FDX1 ELOVL6 FDX2 RXRA SCD FASN CGA SLC27A2 HSD11B1 HSD11B2 IDI2 NFYA EBP NFYB CYP11A1 NFYC TBL1X LGMN NCOA1 ACOT8 CYP11B2 SERPINA6 CYP27B1 TSPO CYP24A1 CYP2R1 CYP21A2 TBL1XR1 FABP6 SUMO2 ABCC3 UBE2I GC NR1H4 HSD3B7 OSBP HSD3B2 PIAS4 HSD3B1 AMACR NCOA2 SLC27A5 NCOA6 RAN INSIG2 INSIG1 CYP19A1 POMC ACAT2 MVD OSBPL9 LBR OSBPL7 OSBPL6 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 BAAT HELZ2 ACOX2 CREBBP CYP11B1 SLCO1A2 SP1 CHD9 OSBPL1A TGS1 AKR1C3 HSD17B4 HSD17B14 IDI1 LRP2 MVK TM7SF2 HSD17B11 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 PPARA TSPOAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer APC FZD5 FZD4 PORCN FZD6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 FZD8 WNT3A LRP5 RNF43 KREMEN1 CTNNB1 KREMEN2 DKK1 TNKS DKK2 LRP6 CTBP2 DKK4 CTBP1 PPP2R1B PPP2R1A TNKS2 PPP2CA PPP2CB AMER1 GSK3B CSNK1A1 PPP2R5E AXIN1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation CYB5B HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NMT2 AKT1 ZDHHC21 CALM1 CAV1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation HBEGF SH3KBP1 EGF ARHGEF7 CBL EGFR UBA52 STAM STAM2 HGS PTPRK EPS15L1 PTPN12 EPN1 UBB SPRY1 PTPN3 CDC42 UBC RPS27A SH3GL3 AREG EPS15 SH3GL2 SH3GL1 SPRY2 TGFA EREG BTC EPGN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis MT-ND6 MT-ND4 NDUFC2 MT-ND5 NDUFC1 MT-ND2 MT-ND3 NDUFS8 MT-ND1 NDUFS7 NDUFS6 PYURF NDUFS5 NDUFS4 NDUFS2 TMEM126A NDUFS1 TMEM126B NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFAF8 FOXRED1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFA9 NDUFA8 NDUFAF2 NDUFA7 SFXN4 NDUFA6 NDUFAF3 NDUFAF1 NDUFA3 NDUFA2 NDUFA1 TMEM186 ACAD9 OXA1L DMAC1 DMAC2 NDUFS3 TIMMDC1 NUBPL LYRM2 HSCB NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 ECSIT NDUFB10 HSPA9 NDUFB11 NDUFV3 NDUFV2 NDUFB8 NDUFV1 COA1 NDUFA5 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling SLC25A14 UCP1 SLC25A4 PM20D1 UCP3 SLC25A27 UCP2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer SKP1 RBX1 NOTCH1 CUL1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TIAM1 ERBIN ARHGAP26 MPP7 VANGL1 RAC2 ARHGAP32 ABI2 TAOK3 PIK3R2 PIK3R1 ABI1 ESYT1 SAMM50 MTX1 ABR MCF2 PLD2 CDC42 DOCK4 ANKLE2 DOCK3 ARHGDIA LAMTOR1 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 IQGAP1 TFRC NCF2 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 EMD LBR GIT1 TMPO SWAP70 ARMCX3 CYBB CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 DSG2 VAMP3 RAB7A CDC42EP4 EPHA2 GARRE1 TRIO ARHGAP17 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 VAV3 NHS SLITRK5 DEF6 VAPB NCKAP1L PAK2 WASF2 PIK3CA PIK3R3 PAK4 DIAPH3 ITGB1 VAV1 GIT2 VAV2 CAV1 MCAM TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 INS PLK2 NPAS4 MAPK1 ARNT2 REST BMAL1 SRF NR3C1 MAPK3 CDK5R1 RET KCNIP3 CREBBP GEM ARNT TNRC6C MOV10 NAMPT CDK5 AGO3 AGO4 RBFOX3 AGO1 AGO2 MDM2 TNRC6A TNRC6B IQSEC3 BDNF XPO1 FOS SYT10 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B GALNT12 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 SULT1C4 SULT2A1 SULT1A3 TPST2 TPST1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression JUN ZNF217 EBAG9 KDM4B YY1 DDX5 GPAM CXCL12 ESR1 POU2F1 TBP HSP90AA1 CARM1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 H3-3B H3C8 MED1 H2AC8 H2AC6 CTSD H2AC7 H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 HSP90AB1 KDM1A CCND1 PTGES3 NRIP1 FKBP4 NCOA1 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 KANK1 CREBBP SP1 BCL2 CDK9 KAT2B FOXA1 TLE3 KPNA2 TGFA USF1 FOS GREB1 CHD1 PGR TFF3 TFF1 CXXC5 USF2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation BANF1 XRCC6 XRCC4 XRCC5 LIG4 PSIP1 HMGA1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PARS2 YARS2 KARS1 EARS2 LARS2 PPA2 NARS2 RARS2 TARS2 AARS2 CARS2 VARS2 HARS2 MARS2 DARS2 SARS2 FARS2 IARS2 QARS1 WARS2 GARS1 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 MET STAT3 HGF VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 STAT5A STAT5B BCL2L1 CDKN1A PIK3R1 GRB2 NRAS PIM1 HRAS GAB2 PIK3CA FLT3 NOX4 PTPN11 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion ALPI MGAM PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B SI AMY1C CLPS LCT GUCA2B CEL GUCA2A CHIT1 LIPF PNLIP PIR PNLIPRP3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production KIF28P IFNA2 IFNA8 MAFG IFNA13 IFNA14 IFNA16 IFNA17 KIF5C ABL1 MFN1 KIF21A MFN2 KIF21B KIFAP3 KLC1 KLC4 IFNA10 KLC3 KLC2 PRKACG IFNA21 PRKACA IFNB1 PRKACB KIF16B KIF3A KIF20B WEE1 KIF3B KIF3C KIF5B CDK5 KIF5A KIF18B KIF4B KIF4A KIF12 PHF21A KIF11 DOCK11 KIF15 KIF19 KIF13B VPS45 KIF1C KIF1B KIF1A KIF25 KIF22 RCOR1 KIF6 KIF27 SH2B2 KIF9 KIFC2 KIFC1 HMG20B DOCK6 DOCK9 CABLES1 DOCK8 DOCK7 RAB5A CAPZB MYB KIF26A KIF26B GATA6 H3-3B H3C8 PRKAR1B PRKAR2B KIF23 PRKAR1A RAC1 PRKAR2A ZFPM1 RBSN KIF20A KIF18A GATA2 H3C15 IRF1 IRF2 NFE2 HDAC1 HBB KDM1A KIF2A SIN3A CDK2 KIF2C KIF2B CAPZA2 CDC42 ITPK1 DOCK5 HDAC2 CENPE DOCK4 DOCK3 CBX5 SH2B3 GATA4 JMJD1C HBE1 GATA1 DOCK2 ZFPM2 DOCK1 GATA5 AK3 MICAL1 CARMIL1 HBG2 GATA3 HBG1 EHD1 EHD2 EHD3 MAFF HBD DOCK10 AKAP10 AKAP1 SH2B1 CABLES2 JAK2 MAFK CAPZA1 RAD51B RACGAP1 RAD51C TP53 IFNA5 IFNA4 IFNA7 IFNA6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism MAN2C1 MANBA MAN2B1 MAN2B2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease FGF18 SOS1 FGF1 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGFR3 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA FGF16 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis GP5 GP9 SERPING1 KLKB1 GP1BA ADAMTS13 F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 MAPK1 FST FOXH1 ACVR1B FSTL3 ACVR2B ACVR2A INHBB DRAP1 INHBA ACVR1C INHA MAPK3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs YAP1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ABL1 H2AC20 ITCH LMO1 LMO2 PSMD8 PSMD6 TCF3 PSMD7 TCF12 LDB1 PSMD2 PSMD3 PSMD1 GATA1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 GATA3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CDK7 PSMB4 MNAT1 PSMB5 H2AX UBB PSMB2 SPI1 PSMB3 H2AB1 UBC H2AC19 PSMB1 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 MYB H3-3B ADRM1 H3C8 H2AC8 H2AC6 PSMC5 H2AC7 PSMC6 H2BC17 SEM1 PSMC3 RUNX1 PSMC4 H2BC12 PSMC1 H2BC13 PSMC2 H2BC14 TP73 H2AJ H2BC15 TAL1 H2BC11 KMT2A CBFB GATA2 H3C15 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1D HTR1A HTR7 HTR1B HTR5A HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NTRK1 SOS1 MAPKAPK3 SHC1 NGF MAPKAPK2 NRAS MAPK14 MAPK11 RALA SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A13 SLC25A18 SLC17A8 SLC6A1 SLC6A5 SLC22A2 SLC22A1 SLC6A4 SLC6A7 SLC6A19 SLC6A2 SLC6A15 SLC6A11 SLC6A3 SLC6A14 SLC6A9 SLC17A6 SLC6A20 SLC17A7 SLC25A22 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR CYP11A1 FDX1 FDX2 FDXR RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 BCL2L11 FOXO3 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation TLL2 TLL1 LAMB3 COL7A1 LAMA3 LAMC2 BMP1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L POLI UBB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC14A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 CDC20 ANAPC15 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF28P KDELR1 KDELR3 SURF4 KIF5C KIF21A KIF21B KIFAP3 KLC1 KIF2A KLC4 KLC3 KLC2 NSF KIF2C KIF2B RINT1 ARF3 KIF16B KDELR2 KIF3A KIF20B COPB2 COPA TMED10 SEC22B KIF3B TMED2 KIF3C KIF5B KIF5A KIF18B KIF4B KIF4A COPE KIF12 CENPE ARF4 KIF11 USE1 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 COPB1 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 ARF1 ARF5 NAPA GBF1 NAPB NBAS RAB1A STX18 RAB1B NAPG BNIP1 ARFGAP3 ARFGAP2 ARCN1 ZW10 KIF26A KIF26B COPG2 COPG1 KIF23 RACGAP1 KIF20A KIF18A ARFGAP1 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 RBBP4 DAXX NUP37 RBBP7 PML H2AC19 DYNC1LI1 H2BC26 H2AC14 DYNC1LI2 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 H2BC17 CHMP2B VPS4A CHMP2A H2BC12 MVB12B H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 ITGB1 H3C15 H2BC9 H4C9 CHMP3 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 HNRNPK SUZ12 H2AC17 H2AC12 NUP214 TRIM28 H2AC25 H2AC21 EZH2 VPS36 VPS25 CBX1 SNF8 CHMP1A CEBPD ELK1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 ESR1 CBFB RSPO3 FOXP3 AXIN1 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX PRDM1 RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM PNP ITPA NT5E NT5C NT5C1A XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades JUN PDGFB RASGRP1 RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB PRKG2 IL2 IL3 IL6 CDC14A FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA RAC1 KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 KALRN DNAJB1 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB SHC2 HSPB1 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 XPO1 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PAK1 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP SEPTIN7 PAK2 CDC14B ARL2 RAG2 RAG1 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A ETV4 RASA3 RASA4 RASA2 ABHD17C IGF2BP1 MAPK6 MAPK4 ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR CCND3 FNTB MAP3K11 MAPKAPK5 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 CDC42EP5 FGF3 CDC42EP3 FGF4 CDC42EP2 FGF6 FOXO1 FGF7 FGF9 IL6R RASA1 PAK3 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 CDC42 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 NCOA3 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA FOXO3 PTK2 HGF EREG BTC EPGN UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases USP17L1 RNF146 TOMM20 RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 USP3 IL33 USP2 MUL1 H2AC1 TGFBR1 CDC25A FKBP8 STAM2 TNKS ADRB2 FOXO4 ATXN7 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 NFKBIA TADA3 MDM2 MDM4 TAB1 RIGI USP37 USP33 USP34 PTEN ARRB1 ARRB2 POLB USP30 USP47 USP48 USP49 USP42 USP44 TRAF2 AXIN2 H2BC18 TRAF6 BIRC2 OTUB1 BIRC3 USP13 USP14 BECN1 USP15 USP16 SKP2 USP10 USP12 HGS MAT2B CDC20 USP18 USP19 TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 PSMD1 USP17L30 HIF1A RNF123 AR AXIN1 RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 PSMA1 SNX3 RHOT1 PSMA2 RCE1 UBA52 SIAH2 PSMD12 PSMD11 TADA2B CYLD PSMD14 H2AC25 H2AC21 PSMD13 WDR48 PSMA7 PSMB6 IFIH1 PSMB7 PSMB4 UFD1 PSMB5 IKBKG UBB TOMM70 PSMB2 PSMB3 UBC PSMB1 DDB2 RPS27A KAT2A PTRH2 WDR20 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 PSMC6 SEM1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 PSMC2 USP17L18 USP17L17 TP53 CCNA2 USP9X CCNA1 USP17L19 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 POU5F1 NANOG INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNG13 GNB2 KCNJ2 KCNJ8 KCNJ3 KCNJ11 GNB1 KCNJ4 ABCC8 ABCC9 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 KCNJ1 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression PTK6 PELP1 EPAS1 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism GUSB CD44 ABCC5 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HAS1 HYAL2 HEXB HAS3 HEXA CHP1 HAS2 SPAM1 HYAL1 HYAL3 HYAL4 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud ROBO2 GFRA1 EYA1 BMP4 SLIT2 FOXC2 ITGA8 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 WNT11 ITGB1 GREM1 SALL1 SIX2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism FOLH1 FOLH1B GOT1 ASPG NAALAD2 NAT8L ASPA SLC25A12 GOT2 ASNS SLC25A13 GADL1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX2 HSD17B4 AMACR ACOX3 ACOXL CROT CRAT ACOT8 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism SLC26A2 CSPG4 CHST3 CHST14 HSPG2 PAPSS2 SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B3GALT6 B4GALT1 B4GALT7 GPC1 GPC3 GPC2 ST3GAL3 GPC5 GPC4 NCAN GPC6 HEXB CHSY1 HEXA BGN DCN PRELP CHST6 BCAN OMD EXT1 VCAN KERA SDC1 OGN CSPG5 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A4 TOMT BCHE SLC6A3 ALDH2 COMT ACHE SLC22A2 SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 GORASP2 GORASP1 USO1 CCNB1 RAB2A CDK1 MAPK1 RAB1A RAB1B GOLGA2 CCNB2 BLZF1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 EPHX2 ALOX5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 NRAS PRKCZ SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 DDX5 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ ACE2 VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 HAVCR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 PARP10 PARP6 SFTPD IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C RPS10 STAT2 CHMP4B RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CHMP2B RPS3A RPS26 CHMP2A RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N CHMP3 CHMP6 HLA-H CHMP7 RPN2 HLA-B ZDHHC20 HLA-C TUSC3 ATG14 PRKCSH HLA-F RPN1 ZDHHC5 HLA-G HSP90AB1 HLA-E MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 SDC2 DDOST SDC3 MGAT4C ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 GPC5 SUMO1 GPC4 YWHAB GPC6 TRIM25 SDC1 IKBKE AKT1 IRF7 VHL NUP214 SFN YWHAZ ISCU UBA52 IFIH1 JAK1 TRIM4 IKBKG TOMM70 UBB RIPK2 UBC TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 FURIN VCP STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C ANO8 ANO9 NUP42 NUP85 ANO6 ANO7 TPR ANO4 NUP62 ANO5 UVRAG NUP88 MAP1LC3B ANO2 ANO3 NUP43 RAE1 HSP90AA1 ANO1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 TMPRSS2 NOD1 SRPK2 ANO10 GALNT1 NOD2 AKT2 PDPK1 NRP1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 PRMT1 SRPK1 HSPG2 TJP1 CHUK PTPN11 AGRN ST6GALNAC2 SIKE1 GSK3B ST6GAL1 CSNK1A1 ST6GALNAC3 ST6GALNAC4 CREBBP ST3GAL4 ST3GAL1 ZCRB1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 SNRPG TAB3 TAB2 SNRPE CTSL IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors JUN ZNF217 EBAG9 DDX5 RXRG GPAM CXCL12 POU2F1 NOS3 TBP S1PR3 CARM1 MMP2 MED1 GTF2A1 GTF2A2 MMP3 SCD FASN HBEGF HDAC1 HSP90AB1 PTGES3 CCND1 FKBP4 ATF2 RARG JUND CYP26A1 CYP26B1 TNRC6C MOV10 CYP26C1 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B XPO1 RARB AKT1 POLR2A POLR2B GATA3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 KAT2B KPNA2 GNG10 IGF1R PGR GNG12 CAV1 GNG11 GNG13 FKBP5 GNB2 PPARD KDM4B YY1 GNB1 DHRS4 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNG3 ESR1 GNG2 GNG5 RDH5 GNG4 GNG7 GNG8 HSP90AA1 EGF EGFR CDKN1B H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 PRKCZ H2AC8 CTSD H2AC6 H2AC7 HRAS H2BC17 RUNX1 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 RARA PIK3R3 PIK3CA CBFB H3C15 RXRA CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 NRAS H2AC20 CETP KDM3A HDAC3 KDM1A MAPK1 GNAT3 KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 SRF ABCA1 MAPK3 ABCG8 KDM4A MYLIP ABCG5 NR1H2 FABP5 KCTD6 APOC4 NR1H3 NCOR2 ARL4C EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ESR2 ABCG1 SRC PDK4 GNAI3 GNAI1 GNAI2 CALM1 AXIN1 NCOA2 NCOA3 PDHB NR5A2 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 CCNT1 KAT5 KANK1 MMP9 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 FOXA1 ALDH1A3 ZDHHC7 DHRS9 TLE3 ALDH1A2 TGFA PPID ALDH1A1 USF1 FOS CAV2 ALDH8A1 GREB1 FOXO3 ELK1 CHD1 PTK2 MMP7 EREG TFF3 UHMK1 TFF1 BTC ZDHHC21 EPGN CXXC5 AKT3 DLD USF2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors LTB4R2 OXER1 PTGER4 GPR17 PTGFR PTGER1 LTB4R TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR CYSLTR1 CYSLTR2 PTGIR C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RELA MAP3K7 UBA3 UBE2M PRKACG RAF1 PRKACA PRKACB CD209 CARD11 MALT1 ITPR1 RELB CLEC10A ITPR2 CLEC7A CLEC4A ITPR3 NFKBIA CARD9 CLEC4E MAP3K14 CLEC6A TAB1 PLCG2 PYCARD CLEC4C CLEC4D TRAF6 BTRC IL1B EP300 PAK3 HRAS PPP3CA PPP3CB PDPK1 CASP8 PPP3R1 UBE2N NFATC1 MUC13 NFKB1 NRAS CDC34 NFATC2 CHUK FCER1G IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 MUC12 PRKCD MUC15 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 MUCL1 PSMA1 MUC3A LYN MUC5AC PSMA2 MUC3B UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 NFKB2 PSMA7 MUC1 PSMB6 MUC2 PSMB7 PSMB4 MUC7 MUC4 PSMB5 MUC6 MUC16 IKBKG UBB MUC17 PSMB2 PSMB3 CREBBP MUC19 UBC PSMB1 MUC5B MUC20 MUC21 RPS27A ICAM2 ICAM3 FBXW11 UBE2V1 ADRM1 PSMC5 SYK PAK1 PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 PAK2 RPS6KA5 CUL1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A EIF4G1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IFNA2 OTUD5 IFNA8 ATG5 ATG12 RELA IFNA13 IFNA14 IFNA16 IFNA17 NFKB1 HSP90AB1 UBE2K ITCH IFNA10 PIN1 IFNA21 IFNB1 CHUK ISG15 PCBP2 IKBKB RIPK1 TBK1 IRF3 NFKBIA MAVS DHX58 RNF125 TKFC TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 TRIM25 IKBKE IRF7 SIKE1 TANK TRAF2 UBE2D1 HSP90AA1 TRAF3 TRAF6 UBA52 FADD CYLD NFKB2 IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG TOMM70 UBB CREBBP UBC RPS27A CASP10 NLRX1 EP300 NLRC5 UBA7 AGER RNF135 S100A12 MAP3K1 APP S100B SAA1 HMGB1 NFKBIB CASP8 UBE2L6 IFNA5 HERC5 IFNA4 IFNA7 IFNA6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR RUNX1 ELF1 CBFB IL3 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis PNMT DDC TH DBH DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts RXRA SLCO1A2 ABCB11 NCOA2 SLCO1B1 SLC27A5 FABP6 SLCO1B3 ABCC3 ALB SLC10A1 SLC10A2 STARD5 NR1H4 SLC51A NCOA1 SLC51B BAAT DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI2 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF18 TNFRSF1B TNFSF13 TNFRSF14 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells YAP1 ITGA5 GNAQ RELA NFKB1 ABL1 CHUK CAPNS1 CAPNS2 CAPN2 STAT1 PTPN1 IKBKG PPP2R1B ANXA2 PPP2R1A IKBKB PPP2CA PPP2R2A VCL PIEZO1 NFKBIA GNA11 IKBKE PTK2 ITGB3 ITGB1 ITGAV DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NFE2L2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR PSENEN NCSTN APH1B PSEN2 PSEN1 RELA NGFR NFKB1 ADAM17 TRAF6 APH1A SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 RELA PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 MAPK1 GNA13 GNGT2 F2RL2 GNA12 F2RL3 MAPK3 F2R GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 GNG10 F2 GNG12 GNG11 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling ERBIN STUB1 HBEGF HSP90AA1 ERBB2 EGF USP8 EGFR CDC37 UBA52 MATK PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 NRG1 AKT1 EREG NRG3 NRG4 NRG2 BTC AKT3 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases YAP1 ITCH PRDM1 ITPR1 ITPR2 ITPR3 NOS3 PRR5 CHD4 NTRK1 KIDINS220 CRK REST HGS VGF JUNB PRKCB RAC1 VAV3 CRKL VAV1 VAV2 MAPKAP1 TIAM1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ARHGEF7 MAPK7 APH1A PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 SOCS1 MDK WWOX ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 HIF1A FES POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K STAM POLR2L RALA WWP1 GTF2F1 GTF2F2 RAB4A PTPN18 PTPN12 PTPN2 AAMP MKNK1 SPRY2 ALK AHCYL1 PRKCE PGR MST1 MEF2A MST1R RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 USP8 STAM2 SPHK1 CDK5 ESR1 ADAM17 CYFIP2 PTPRU SH2B2 CMA1 FER TEC GRAP RAB4B KLB FLT3 IRS1 PPP2R1B PDE3B IRS2 PPP2R1A PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 NCK2 PTPRF FGF4 FGF6 NCK1 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 DIAPH1 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 ITGB1 TLR9 PIK3C3 TRIB3 ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 GFAP ATP6V1B1 ATP6V1A SHC1 PPP2R5D PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 SGK1 FGF20 THEM4 RHOA ATP6V1H PTPRJ MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 SRF ATP6V0A1 CDK5R1 MAPK3 PTPN1 INSR PTPN11 FGF16 CDC42 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FAM83B FGF10 HNRNPM HNRNPF SRC NRG1 DOCK3 GRIN2B HNRNPH1 DLG4 CALM1 DOCK1 FLT1 FLT4 KDR VEGFB VEGFC PTK2B VEGFD THBS1 PGF VEGFA ERBB2 ESRP1 MEMO1 CTNND1 CTNNA1 BAX CSK JAK2 SPRED2 RANBP9 SPRED1 CD274 IL2RG NELFB CHEK1 MMP9 BRAF MAP2K5 NCBP1 NRP2 NCBP2 CDH5 FRS3 TNS4 TNS3 LCK FYN HGF FGFRL1 FLRT2 FLRT1 CLTC CLTA AP2A1 NTRK3 AP2A2 NTF3 PDGFB AP2M1 RAP1B RAP1A PRKACG IGF2 PRKACA PRKACB IGF1 AP2S1 CXCL12 PTBP1 AP2B1 PLG STAT5A LAMA5 SH3KBP1 PXN LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 GRAP2 LAMC1 JAK3 HNRNPA1 PDGFRA KIT PTK6 HBEGF HDAC1 FLRT3 SIN3A NAB1 CTNNB1 COL6A2 NAB2 MET COL4A4 LYL1 F3 DNM2 COL6A1 ARC COL4A3 TRIB1 PTPRK TPH1 EPS15L1 ATF2 RRAD EPN1 ASCL1 SPRY1 PTPN3 EGR1 COL6A3 EGR2 EGR3 JUND COL4A5 EGR4 COL6A6 FOSL1 COL6A5 ID2 MLST8 ID1 MYCN MEF2C ID4 FOSB ID3 MYC CDK5R2 SPINT1 TGFBR3 HPN SPINT2 HGFAC MTOR YWHAB HSPB1 LRIG1 SOCS6 SH2B3 AKT1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 NCF2 NCF4 BRK1 MAPKAPK2 UBA52 MATK GIPC1 ANOS1 CYBB CYBA UBB RAPGEF1 UBC RPS27A RNF41 CUL5 MAPK14 MAPK11 PAK1 NCKAP1L WASF1 IRS4 PAK2 IGF1R CILP WASF2 CAV1 ERBIN BAIAP2 ABI2 FURIN PCSK6 ABI1 NGF PCSK5 SPP1 RICTOR ROCK1 ROCK2 ADAM12 STAT1 ELMO1 HSP90AA1 NEDD4 EGF CBL JUP EGFR CDC37 PLCG1 STMN1 RBFOX2 PDGFD SHB FGFBP3 FGFBP1 FGFBP2 ARF6 ALKAL2 ALKAL1 TIA1 TNK2 DOCK7 ADAP1 ESRP2 PTPRZ1 CSN2 TIAL1 SH2D2A PAG1 RANBP10 PTPRO PTN AXL PLAT FAM83D FAM83A MXD4 LTK EP300 THBS4 RASA1 THBS3 PRKCZ PAK3 BCAR1 NRP1 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 NRG2 ITGAV COL4A2 COL4A1 PTPRS SPARC STAT3 HDAC3 ITGA2 GABRG3 APOE GABRG2 COL9A1 GABRB3 COL9A3 GABRB2 COL9A2 GABRB1 NCOR1 GGA3 HDAC2 STUB1 STAT5B GABRQ GABRA1 GRB2 THBS2 ATF1 GALNT3 DNMT1 MAPKAPK3 MUC20 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 PTPN6 YES1 MEF2D STAT6 NTF4 PDGFRB S100B NTRK2 BDNF TGFA TAB2 FOS ELK1 PTK2 EREG BTC EPGN AKT3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HPGDS TBXAS1 PTGES PTGES2 PTGR2 CBR1 PTGIS PTGS2 PTGS1 CYP8B1 AKR1C3 PTGES3 PTGDS HPGD PRXL2B ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX BAX BID CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 CD22 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PTPN6 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME CYP2E1 UGT2B7 CYP2C9 UGT1A3 CYP2C8 ABCC2 CYP2C19 ACSM2B ABCC3 CYP2D6 SLC16A1 SLC22A7 UGT2B28 ALB CES2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 BCHE UGT3A1 UGT2A1 UGT1A8 GLYATL3 BSG UGT1A7 GLYATL2 UGT1A6 GLYATL1 ACSM2A CYP3A4 UGT2B10 ACSM5 UGT2B11 GLYAT UGT1A1 CES1 ACSM4 UGT2B15 UGT1A9 UGT2B17 UGT2B4 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer TP53 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection CLTC KPNA7 KPNA4 KPNA5 CLTA GBP1 KPNA3 CPSF4 TGFB1 EIF2AK2 ISG15 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 KPNA1 PABPN1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 NUP37 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 MLKL RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 CALR CANX RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 XPO1 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 HSPA1A KPNA2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNG13 CLTC CLTB WNT5B FZD7 WNT5A ROR1 GNB2 ROR2 CLTA GNB1 AP2A1 PRICKLE1 WNT1 FZD1 MAP3K7 GNB4 AP2A2 RYK FZD8 GNB3 GNB5 AP2M1 GNGT1 GNGT2 PRKG2 AP2S1 GNG3 SMURF2 ITPR1 ITPR2 GNG2 ITPR3 GNG5 AP2B1 GNG4 GNG7 GNG8 ARRB2 SCRIB VANGL2 DAAM1 PFN1 PARD6A PRKCB RAC1 DVL1 DVL2 DVL3 PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 RAC2 GNAO1 TCF7L2 TCF7L1 LEF1 TCF7 RHOA CTNNB1 TNRC6C MOV10 AGO3 AGO4 SMURF1 AGO1 AGO2 TNRC6A TNRC6B CAMK2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RAC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 WNT4 PSMC1 PSMC2 PRKCG GNG10 GNG12 GNG11 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 RB1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 SKP2 ANAPC15 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 FUCA1 MGAT3 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 B4GALT6 SEC22B B4GALT5 MAN2A2 LHB SERPINA1 SEC23A COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 MANEA TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B B4GALT2 TRAPPC3 B4GALT3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A B4GALT4 TRAPPC6B CGA SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 FUT8 NSF MAN2A1 CTSC MGAT5 CAPZA3 MGAT1 MGAT2 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A MGAT4C TMED2 MGAT4A SPTB DYNC1I1 MGAT4B B4GALT1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 ST6GAL1 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ST3GAL4 ANK1 AREG ST8SIA6 DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 ST8SIA2 TGFA ST8SIA3 YKT6 ARFGAP1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation MAPK1 RAPGEF1 RAP1A FRS2 NGF MAP2K1 MAP2K2 CRKL MAPK3 BRAF YWHAB RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MBD2 MAPK3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants UBC RPS27A FLT3LG CBL UBA52 FLT3 UBB MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN CSNK2A1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects APRT HPRT1 ADA TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs KIT HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 RNF8 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e DPM3 DPM1 DPM2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope DSG1 DSG3 FURIN PERP PCSK6 LCE6A IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KLK13 KLK14 LCE3E KLK12 LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A LCE1B KAZN LIPJ LIPN LIPM JUP PRSS8 PI3 LIPK PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 LCE1E LCE1F LCE1C CAPNS1 LCE1D LCE2B PKP4 LELP1 CAPN1 LCE2C LCE2A LORICRIN FLG SPRR2E SPRR2F DSG2 SPRR2G TCHH PKP1 KLK5 KLK8 PPL CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN SPRR1A SPRR1B DSG4 CASP14 LCE5A DSP PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds UGT2B7 GSTA3 GSTA1 COMT HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM MGST3 MGST1 MGST2 GSTP1 MTRR MAT1A NNMT CYP1A2 MAT2B AHCY SLC35D1 SLC35D2 SULT2A1 TPST2 TPST1 GSTM4 TPMT AS3MT AKR1A1 GSTT2 GSTT1 ESD GSTT2B UGT1A3 GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 MAT2A GSTA5 GSTA4 CHAC1 PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 ACSM1 BPNT2 ACSM2B BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 MTR HPGDS GSTZ1 GSTO1 NAT1 NAT2 GSTA2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 UGDH UGT2B4 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 MFAP5 BMP4 MFAP4 MFAP3 MFAP2 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 BMP10 LTBP4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP41 CEP43 DYNLL1 CKAP5 TUBA1A RPGRIP1L PRKACA MAPRE1 PAFAH1B1 DYNC1I2 MKS1 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 YWHAE CEP97 CC2D2A TUBB4B IQCB1 TUBB4A KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 YWHAG SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 RAB3IP CEP290 NINL RAB11A CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins ACOX1 HSD17B4 AGPS SCP2 ACAA1 PHYH TYSND1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria YWHAH YWHAZ SFN BCL2 AKT2 YWHAB PPP3CC BID YWHAE AKT1 PPP3R1 BAD YWHAQ YWHAG AKT3 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b MOGS STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B BCL2L1 CDKN1A GRB2 GAB2 FLT3 NOX4 PIM1 PTPN11 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP5B SYNJ1 INPP5A IMPA1 MTMR9 INPP4A IMPA2 MTMR7 INPP4B INPP5J MIOX ISYNA1 OCRL INPP1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 GLYAT VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance APOC4 LSR APOB VLDLR APOBR APOC1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism MRI1 ENOPH1 BHMT2 FMO1 BHMT ADI1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 MAT1A TST ETHE1 SLC25A10 CDO1 AHCY CBS MTAP CTH MTR GOT1 APIP MTRR TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 F9 PROC F10 PROS1 PROZ F2 BGLAP GAS6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System RELA ARPC1B ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 RAB9B IRAK1 NCKIPSD MGST1 C4A CAT RETN FUCA2 DNAJC3 RAC1 VAV3 CST3 PRKCQ UBE2N VAV1 VAV2 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 NFATC2 V1-11 CPB2 CFH V1-16 V1-13 MAPK8 C5AR2 CFI CDK13 CAPZA2 C5AR1 C4B_2 C2 ACTR10 C5 HSPA1B C6 SOCS1 C7 C9 CD19 IKBKB V2-8 V1-20 MYD88 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S UBE2D2 C1R UBE2D3 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 RAB3A POLR2E POLR2F POLR2H POLR2K DNAJC5 POLR2L KRT1 TOLLIP ACTB CSNK2B CNPY3 TLR8 CTSB TP53 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B NLRC4 RAB5C BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 ACTG1 FCAR ALAD FCGR3B PPP2R1B PGM2 PPP2R1A ACP3 SNAP29 PGM1 RNASET2 TNFRSF1B DYNC1LI1 PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 TXN DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PPP2R5D PRG3 DYNLL1 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 CHUK MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA DNASE1L1 PPP2CB CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CD93 CASP1 CD300A CASP2 IRAG2 ATAD3B OSCAR TYROBP DOK3 CRCP COPB1 ADGRG3 DPP7 MGAM POLR3GL HSPA6 GGH POLR3A POLR3B DNAJC13 ADA2 POLR3C IGF2R POLR3D POLR3E SELL TARM1 POLR3F POLR3G MAN2B1 MS4A3 POLR3H DDX3X TNFAIP6 POLR3K CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 NFKB2 ADGRE5 NAPRT ADGRE3 FGB HGSNAT DYNLT1 ATP6AP2 FGA PLAUR LRRFIP1 MMP8 MMP9 FGG CHI3L1 PDXK BIN2 FCN2 CLEC12A MVP FCN3 CAND1 CRP COLEC10 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN SKP1 PROS1 F2 CUL1 AP2A2 SLC15A4 RASGRP2 RASGRP1 RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB NPC2 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 LBP IGKV3-20 IGHV4-34 IGHV1-2 ITK IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 VTN IGLC2 BTRC IGKV3D-20 TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C AMPD3 IGKV5-2 APRT IGLC6 IGKV1-5 PNP IMPDH1 IMPDH2 LIMK1 PPP3CA EEF1A1 MYH9 PPP3CB UBE2L6 HERC5 PPP3R1 NFATC1 HLA-H HLA-B HLA-C HSP90AB1 IGHE HLA-E CDC34 DNM2 ATG7 CAB39 CTSS VAMP8 TLR6 HUWE1 IKBKE LAMTOR2 IRF7 LAMTOR1 TANK LAMTOR3 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 STBD1 CEP290 NFATC3 TUBB S100A1 CYBB CYBA RAB7A UBE2V1 UBA7 UBR4 PAK1 MEFV PSTPIP1 NCKAP1L SUGT1 WASF1 PAK2 WASF2 CALM3 CALM2 RASGRP4 BAIAP2 ATP8A1 ABI2 UBA3 ABI1 UBE2K ATP11B UBE2M ATP11A TIRAP CARD11 MALT1 ATP8B4 RELB CLEC10A CLEC7A CARD9 CLEC4A WIPF1 CLEC4E MAP3K14 WIPF2 CLEC6A DHX58 WIPF3 RNF125 TAX1BP1 RNF216 FCGR1A ARHGAP45 IQGAP1 ANO6 PLD1 IQGAP2 JUP ARHGAP9 WASL WAS STOM PAK3 MYO9B MAP2K1 COLEC11 HSP90B1 ITGAV FTH1 MASP1 FTL XRCC6 XRCC5 ITGAX DGAT1 FABP5 SIKE1 GPI CD36 HK3 KLRK1 PGAM1 KIR3DS1 DHX36 PRKDC FCER1A LAT2 NCR2 BCL10 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E NKIRAS2 LPO MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 TLR10 BCL2 TLR5 ALPK1 LRRC14 NLRX1 PELI3 BCL2L1 PELI2 PTPN6 NLRC5 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 STAT6 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB ELK1 POLR1C PTK2 POLR1D IFNA5 IFNA4 IFNA7 IFNA6 JUN IFNA2 IFNA8 AGPAT2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 CD209 GM2A NOS1 APEH ARSA FGR ASAH1 PECAM1 ITPR1 ITPR2 ITPR3 PSAP TKFC APOB MBL2 NOS2 NOS3 MME GLA P2RX7 CRK P2RX1 FADD IST1 CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 KPNB1 IL1B PELI1 TLR4 GSN TICAM2 TICAM1 PKP1 LY96 SDCBP HMGB1 CASP8 CASP5 CASP4 DSP DUSP4 DSG1 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 PRKCSH MAGT1 LTA4H NCSTN ADAM10 PSEN1 DNM1 GOLGA7 LGMN DDOST LPCAT1 ALOX5 DNM3 MAPK12 MAPK13 TRIM25 HPSE LYN BTK CYLD CNN2 CFL1 IFIH1 TRIM4 IKBKG ANXA2 TOMM70 RIPK2 MIF CAPZA1 AAMP PPIA RNF135 AHCYL1 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 NFKBIA MAVS CYFIP2 TAB1 RIGI TNFAIP3 HMOX2 SLC44A2 GLIPR1 TRAF2 TEC TRAF3 TRAF6 BIRC2 BIRC3 STK10 USP14 NOD1 NOD2 USP18 ORMDL3 PIK3CB TCIRG1 PTGES2 NCK1 TNIP2 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B CD180 ATP6V0E1 LY86 ATP6V1G2 EEA1 PDPK1 TASL RBSN IRF5 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 ATP6V0D1 FAF2 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS ATP6V0A2 PLD4 ATP6V1H MAPK1 PLD3 ATP6V0A4 PANX1 DHX9 ATP6V0E2 ATP6V1G3 ATP6V1D ALDH3B1 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PCBP2 PTPN11 PLD2 DEGS1 UNC93B1 TLR3 CKAP4 LRRC7 CALM1 DOCK2 DOCK1 MOSPD2 UBE2D1 MRE11 ARMC8 MYO5A FBXW11 OPTN RAB27A CEACAM1 SEM1 APP LAMP2 PPIE ARG1 SERPING1 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 SERPINA3 DEFB117 DEFB116 ORM1 FPR2 SLC11A1 SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 ORM2 DEFB110 TLR1 DEFB130A BPI QSOX1 PRTN3 DEFB130B S100A9 CAP1 DEFB4B S100A8 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PTAFR PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 ACLY ATG5 ATG12 SLC27A2 CTNNB1 ACAA1 ATF2 TREM2 SIGIRR IRAK3 MEF2C B4GALT1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 KCNAB2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 CASP10 ICAM3 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A CASP9 APAF1 CASP3 CFD C3 GZMM CFB VAPA CCT2 ROCK1 ZBP1 TREX1 DDX41 DTX4 TBK1 B2M IRF3 STING1 AP1M1 NLRP4 TRIM32 TRIM21 TRIM56 ELMO1 HEXB GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 FRK PLCG1 EP300 NDUFC2 NFKB1 PIN1 CHRNB4 ITGAL MUC12 MUC15 PTPN4 MUCL1 MUC3A MUC5AC MUC3B LGALS3 CFP MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 NEU1 MUC5B MUC20 MUC21 CTSA YES1 EEF2 MLEC CTSV CTSL CTSK MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 TYK2 JAK2 JAK1 IL6R MAP2K2 PTPN11 IL6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability HSP90AA1 JUP CTNND1 THEM4 CTNNA1 RICTOR CTNNB1 CDH5 MLST8 AKT2 PAK1 PAK3 MTOR RAC1 VAV3 NOS3 PRR5 PDPK1 PAK2 AKT1 VAV1 CALM1 CAV1 VAV2 MAPKAP1 AKT3 TRIB3 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB GLYCTK KHK ALDH1A1 TKFC REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC VCL PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis CDON ABL1 CTNNA1 CTNNB1 MAP2K6 CDC42 CDH2 NEO1 NTN3 CDH4 BNIP2 MEF2C CTNNA2 MYOG SPAG9 MEF2B MAPK14 MYOD1 MAPK11 MYF6 TCF4 MEF2D CDH15 MYF5 TCF3 TCF12 MAPK12 MEF2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SMARCB1 SMARCD1 SMARCD2 SMARCD3 PCGF5 HIPK2 SMARCC1 SMARCC2 RYBP ARID2 YAF2 SMARCE1 ACTL6A BMI1 CBX6 EP300 RING1 AUTS2 CSNK2A1 CSNK2A2 RNF2 SMARCA2 RUNX1 ACTL6B SMARCA4 CSNK2B CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 CBFB ARID1A ARID1B PBRM1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PLK1 PSMA6 PSMA3 PSMA4 HSP90AA1 PSMA1 CCNB1 PSMA2 CDKN1A UBA52 PSMD12 HSP90AB1 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 MAPRE1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A GTSE1 FKBPL ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 CCNB2 PSMD2 TP53 PSMD3 PSMD1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation GLI2 IHH HDAC4 CBFB BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion NEDD4L CHMP3 CHMP6 CHMP7 UBA52 UBB UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A PPIA VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 PDCD6IP MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MT-ND4L GFM2 MRRF MT-CYB MTRF1 MTRF1L MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 UBA52 IFNA10 IFNA21 IFNB1 EIF2AK2 IFIH1 JAK1 UBB CREBBP UBC TYK2 RPS27A STAT2 EP300 IRF3 CUL5 IFNAR1 MAVS RIGI ELOB ELOC RBX1 TRIM25 IFNA5 IFNA4 IFNA7 IFNA6 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNJ2 KCNJ4 KCNJ14 KCNK5 KCNK2 KCNK3 KCNK12 KCNK4 KCNK15 KCNK9 KCNJ12 KCNK6 KCNK7 KCNK1 KCNK10 KCNK13 KCNK16 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 PHOSPHO1 LPIN1 LPIN2 LPIN3 CHKB ETNPPL CEPT1 CHKA ETNK2 SELENOI PISD ETNK1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME SLCO1A2 SLC22A8 ABCG2 ALB SLC22A1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling NRG1 HBEGF PIK3R1 PIK3CA NRG3 EREG NRG4 BTC NRG2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling GNAS ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System PRL FGF10 TGFA AREG EGF MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 MAPK3 BRAF UBB GALNT3 PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 FRS3 RPS27A FGF4 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling SOS1 IL15RA STAT5A STAT5B IL15 SHC1 STAT3 IL2RB SOS2 GRB2 JAK3 JAK1 GAB2 IL2RG PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation CACNG4 FGF14 FGF13 FGF12 FGF11 SCN9A SCN11A CACNG6 CACNG7 SCN10A SCN8A CACNA1C RANGRF SCN5A CACNB1 SCN4A SCN4B SCN7A CAMK2B SCN1B SCN1A CAMK2D CAMK2A CACNA2D2 CACNB2 SCN3B SCN3A CACNG8 CALM1 CAMK2G SCN2A SCN2B SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog EVC2 IQCE EFCAB7 SEL1L EVC BOC GAS1 ADCY9 DRC4 CDON ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L CUL3 PRKACA KIF7 PRKACB WDR35 IHH IFT88 VCP SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 DERL2 ERLEC1 SMURF2 OS9 ADAM17 P4HB ARRB1 ARRB2 GNAS GLI1 SUFU BTRC NUMB PRKAR1B PRKAR2B PRKAR1A PRKAR2A NOTUM SPOP GLI3 GLI2 SMURF1 GPC5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 OFD1 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 DISP2 PSMC2 ULK3 SCUBE2 GRK2 SKP1 DZIP1 SPOPL SYVN1 CUL1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 TRIM24 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 ZMYM2 FGFR1OP2 GAB2 PIK3CA MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A AJUBA YWHAG PLK1 HSP90AA1 CCNB1 CEP57 CETN2 CEP164 UBA52 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 BTRC CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 PPP1CB HAUS5 CSNK1E UBB PPP2R1A TUBG1 HAUS2 HAUS1 CPAP UBC AKAP9 RPS27A BORA CEP63 SFI1 FBXW11 SDCCAG8 OPTN DCTN2 SSNA1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 SKP1 CCNB2 ODF2 CEP152 NEDD1 ALMS1 CUL1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes ZNF420 TNFRSF10C PRELID3A BNIP3L TNFRSF10B TNFRSF10A PERP PRELID1 TNFRSF10D TMEM219 NLRC4 BAX BID BIRC5 TP63 PPP1R13B FAS CREBBP CHM BBC3 RABGGTB RABGGTA NDRG1 BCL6 CASP10 PMAIP1 STEAP3 AIFM2 TP53AIP1 TP53INP1 CRADD TP53I3 IGFBP3 TP73 TP53 CASP6 ATM CASP1 TRIAP1 CASP2 PIDD1 TP53BP2 APAF1 BCL2L14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 IGLV2-11 IGLV1-40 HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LRP1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4C GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D PLA2G4E PLA2G4A PLA2G4B CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD MC2R POMC DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins GSN SPTAN1 DBNL PLEC CASP8 CASP6 ADD1 GAS2 CASP7 MAPT CASP3 VIM REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSF1 HSPA2 MAPK3 HSPA1B HSPH1 YWHAE NUP205 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA8 RPA1 RPA2 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation MIB2 ITCH UBE2L3 BTRC RNF111 UBE2V2 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF126 CDC34 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SOCS1 HACE1 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 LRRC41 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 KLHL5 PSMA5 RLIM PSMA6 TRIP12 PSMA3 KBTBD7 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 RNF19B UBE3A PSMD12 UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 NPEPPS PSMD13 RNF19A PSMA7 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 UBE2E3 TRIM4 PSMB4 FBXO17 PSMB5 FBXO15 UBE2E2 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 RNF14 KBTBD13 CUL3 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 RBBP6 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 SMURF2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 ASB2 ASB3 SKP2 ASB1 CDC20 SOCS3 SH3RF1 FBXO32 MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 FBXL21P SEM1 SKP1 CUL1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RRAS RAC1 PLXNB1 MET RND1 ARHGAP35 SEMA4D RHOA PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling XIAP RACK1 TRAF1 ULK1 MAP3K7 USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 RBCK1 NSMAF SMPD3 SMPD2 CHUK IKBKB RIPK1 SHARPIN TBK1 ADAM17 TAX1BP1 TAB1 UBE2D2 UBE2D3 TNFAIP3 RNF31 IKBKE SPATA2 TNFRSF1A OTUD1 STUB1 UBE2L3 TRAF2 BAG4 UBE2D1 MAPKAPK2 UBA52 BIRC2 FADD BIRC3 CYLD OTUD7B IKBKG UBB UBC RPS27A USP21 TNF OPTN OTULIN TRADD TAB3 TAB2 CASP8 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK6 KCNK7 KCNK1 KCNK2 KCNK3 KCNK10 KCNK4 KCNK9 KCNK13 KCNK16 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling RELA MAP3K7 PTPN22 CARD11 MALT1 NFKBIA PTEN PLCG2 VASP ITK TRAC CD3G CD3E TRAF6 PLCG1 CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 PTPRC ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 CD4 HLA-DRB1 PAG1 HLA-DQB2 LAT PIK3CB CD101 HLA-DQB1 NCK1 WAS PAK3 PDPK1 PRKCQ PIK3CA UBE2N PIK3R2 PIK3R1 NFKB1 CDC34 PTPRJ EVL CHUK IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 ZAP70 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 INPP5D PSMA2 TRAT1 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 CSK PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB RIPK2 PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TAB2 PAK2 CUL1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE MMAA PCCA MMUT PCCB AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production RACK1 NSMAF SMPD3 SMPD2 TNF TNFRSF1A DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade RAC2 LYN RHOG PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 RHOA RHOB GP6 FCER1G LCP2 PTPN11 PIK3CB CDC42 LAT PDPN MPIG6B CLEC1B PTPN6 PRKCZ SYK RAC1 LCK FYN VAV3 PDPK1 PLCG2 PIK3R3 PIK3CA VAV1 VAV2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template PCNA UBA52 NPLOC4 POLH USP10 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1 TGIF2 CCNK SERPINE1 FURIN CCNC HDAC1 CDKN2B UBA52 MAPK1 COL1A2 CCNT1 TFDP1 MAPK3 TFDP2 UBB UBC CDK8 SP1 SMAD2 RPS27A SMAD4 CDK9 YBX1 SMAD3 EP300 SMAD7 MYC JUNB RNF111 MEN1 WWTR1 E2F4 CCNT2 E2F5 RBL1 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD MAT1A MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation TYK2 JAK2 JAK1 MAP2K1 IL6R MAPK3 CDK1 PTPN11 IL6 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis NEU1 GLB1 CTSA FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation FGF18 FGF1 FGF9 FGF20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism RXRA OSBP NCOA2 AMACR SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 SLC51A NCOA1 SLC51B CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 SLCO1A2 OSBPL1A ABCB11 AKR1C1 FABP6 ABCC3 AKR1C2 ALB AKR1C4 SLC10A1 SLC10A2 CYP8B1 STARD5 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2E1 CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 PSIP1 HMGA1 OPSINS%REACTOME%R-HSA-419771.3 Opsins OPN1MW OPN1LW RHO OPN1SW OPN4 OPN3 RRH RGR OPN5 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type CSPG4 AGRN B4GALT7 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 PATL1 EDC3 EDC4 DCP1B XRN1 DCP2 DCP1A LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DDX6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells HNF1A MAFA RFX6 IAPP FOXA3 GCK FOXO1 PDX1 INS NKX6-1 AKT2 PAX6 SLC2A2 HNF4G AKT1 FOXA2 NEUROD1 NKX2-2 AKT3 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing SNRNP200 SNRPD2 SRSF6 SNRPD1 SRSF7 SNRPD3 SNRPB PRPF8 ZMAT5 RNPC3 ZRSR2 DDX42 YBX1 SRSF1 DDX23 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E POLR2F POLR2G POLR2H SF3B1 POLR2I POLR2J POLR2K POLR2L GTF2F1 SNRNP40 GTF2F2 PDCD7 SNRNP48 EFTUD2 NCBP1 NCBP2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRPG SRSF2 SNRPE SNRNP25 SNRPF CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN TNKS2 TNKS FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm SOX17 SMAD2 SMAD4 GSC SMAD3 MIXL1 TCF7L2 CDH1 GATA6 TBXT EOMES CXCR4 CTNNB1 GATA4 FOXA2 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway MAP3K7 TRAF6 BIRC2 BIRC3 CYLD ITCH CHUK NOD1 MAP2K6 NOD2 IKBKG RIPK2 IKBKB IRAK1 UBE2V1 CARD9 AAMP MAPK14 IRAK2 MAPK11 TAB1 TAB3 TNFAIP3 TAB2 MAPK12 CASP8 MAPK13 CASP1 CASP4 CASP2 CASP9 UBE2N GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 TAS2R16 FZD8 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 TAS2R46 RXFP4 MRGPRD FZD10 RXFP1 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R SSTR1 CGA SSTR2 WNT16 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 PTHLH CNR2 CNR1 TSHR ACKR1 C5AR2 C5AR1 C5 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 TSHB PF4 TAS1R2 TAS1R1 TAS1R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 LHB ADORA2B GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CRH WNT3 WNT8A WNT8B NPY CXCR1 CXCR2 OPRM1 OPRK1 POMC CXCL1 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CCR5 CXCR6 CCL7 CXCR4 CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 EDN1 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH CYSLTR2 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 HTR2B HTR2C ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 WNT3A WNT9A C3 SMO PTCH1 OPN1LW OXER1 OPN1MW RHO RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 SAA1 MC2R DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth COL4A2 CACNA1D NCAM1 COL4A1 SOS1 NRAS MAPK1 COL6A2 COL4A4 COL6A1 COL4A3 MAPK3 PTPRA CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 SPTB COL6A5 AGRN NCAN SPTBN4 SPTBN5 SPTBN2 PRNP ARTN GFRA1 GFRA2 GFRA4 NRTN CACNA1C SPTAN1 SPTA1 CACNA1S PSPN GDNF CNTN2 ST8SIA4 HRAS FYN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PTK2 SPTBN1 RPS6KA5 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses IFNA2 IFNA8 IFNA13 MAP3K7 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 STAT1 SAR1B NLRP3 SEC23A TBK1 B2M LARP1 IRAK1 IRF3 IFNAR1 STING1 MAVS HLA-A TLR1 TKFC G3BP1 TAB1 G3BP2 RIGI MBL2 CNBP TLR2 NUP205 POM121 NUP107 SFTPD NUP188 IL17RC IL17RA SEC24B AAAS NLRP12 NUP160 SEC24A IL17F POM121C IL17A NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 TRAF3 RANBP2 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C TLR7 NUP37 NOD1 NOD2 STAT2 UBE2N PIK3C3 MASP1 HLA-H PIK3R4 HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E CHUK PTPN11 IKBKB TRIM25 IKBKE IRF7 SIKE1 NUP214 IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 CREBBP TYK2 UBE2V1 PTPN6 IRAK2 RNF135 TAB3 TLR8 KPNA2 TAB2 IFNA5 IFNA4 IFNA7 IFNA6 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R2A BANF1 SIRT2 CCNB1 VRK1 CDK1 ANKLE2 LEMD2 EMD LBR LMNB1 CCNB2 KPNB1 LEMD3 PPP2R1A SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy TUFM UVRAG MAP1LC3B VPS41 VPS33B VPS39 VPS18 VPS45 VPS11 VPS16 VPS33A ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity RPS6KA1 HDAC1 LEF1 ZIC1 FOXD3 MAPK1 HINT1 TFE3 MITF TFEC ALX3 TBX3 CTNNB1 MAPK3 EDNRB EPRS1 ID1 CDH1 UBE2I SUMO1 PAX3 YWHAB YWHAE XPO1 SNAI2 GSK3B TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 YWHAZ POMC RARS1 WNT3A SOX10 LARS1 MARK3 AIMP1 AIMP2 QARS1 MARS1 MC1R MC4R DARS1 EEF1E1 MC3R CREBBP KARS1 POU3F2 IARS1 TFEB EP300 MC5R SOX2 SOX9 SIRT1 KIT AKT3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 DVL3 CCDC88C CXXC4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing OGG1 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli YAP1 COX5B COX5A RELA COX6C COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C IL6 YWHAE PRR5 EED CAT PDIA6 IGFBP7 SOD2 WFS1 CARM1 PRKCI DNAJC3 MED1 MAPKAP1 PRDX2 PRDX1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 DNAJA4 DNAJA2 CAPZA2 FKBP4 ACTR10 HSPA1B IKBKB SQSTM1 UBE2D2 UBE2D3 HIF3A LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP CDKN2B CSNK2A1 IGFBP1 CSNK2A2 CSNK2B TP53 GNG10 PGR GNG12 GNG11 GNG13 FKBP5 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 MAP2K6 PRDX6 MT2A MT1A MT1M MT1F MT1G MT1H MT1X MT4 MT1B MT3 MT1E GNG3 GNG2 GNG5 CLEC1B GNG4 GNG7 GNA11 GNG8 GSTP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 SMARCD3 NUP210 HMGA1 CACNG7 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 RBBP4 NUP37 RBBP7 TXNRD1 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 COX7A2L TXN RPS27 ITGB1 CITED2 VENTX PPP2R5B DYNLL1 DYNLL2 HBB NFYA NFYB NFYC CHUK DYNC1I2 BMAL1 PPP2CA COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 HM13 EIF2AK3 NOX4 FLT4 KDR HSPA6 HSPD1 VEGFA TLN1 VCL CDH5 PIEZO1 FYN SKP1 CCNA2 CCNA1 CUL1 CXCL8 MTF1 NUDT2 CREB3L3 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 CHD6 PRKACG GPX3 GPX6 PRKACA GPX5 PRKACB GPX8 GPX7 BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 TRPV4 BTRC RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A GCN1 RPS16 WDR59 RPS19 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT DEPDC5 RPS10 RPS13 KPTN WDR24 RPS12 SH3BP4 RPS9 RPS7 FNIP1 RPS8 FNIP2 PRKAR1B KICS2 RPS5 PRKAR2B CASTOR1 RPS6 PRKAR1A CASTOR2 RPSA PRKAR2A RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 CACNB2 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 HSP90AB1 PRKAA2 SEC31A RPTOR CALR MLST8 SLC38A9 ID1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD AKT1S1 IKBKE LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NCF1 NCF2 NCF4 BAG4 ACTR1A CYBB CYBA DCTN2 CUL7 DCTN3 PGRMC2 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A HSPH1 HYOU1 HBA2 RAMP2 CALCRL ADM ITGB3 HSP90B1 ITGAV ITGA5 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 BMI1 RPL22 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RNF2 RPL12 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 MAP2K3 MAP2K4 CREBBP MAPKAPK3 SP1 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 MAP2K7 MAPK10 FOS FOXO3 PTK2 AKT3 HIKESHI JUN CCAR2 DNAJC2 CXXC1 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 ADCY9 BAG5 DNAJB6 ADCY4 BAG2 ADCY3 BAG3 ADCY2 BAG1 ADCY1 HSPA4 ST13 ADCY8 ADCY7 HSPA7 HSPA12A ADCY6 HSPA12B ADCY5 IFNB1 CSRP1 SNCB PECAM1 GCLC GCLM APOB NOS3 GSK3A P2RX7 GNAS CDKN2D CDKN2C DNAJB11 IL1A FBXL17 BACH1 TLR4 SLC7A11 LY96 OMA1 MAPK7 ADD1 ATF6 CRYAB MAP3K5 DELE1 HERPUD1 MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 KEAP1 AR NRF1 NPLOC4 RPLP0 UBXN7 DPP3 HSPA9 UFD1 IKBKG ANXA2 TALDO1 SOD1 PIK3CD CAPZA1 FKBP14 GOSR2 GPX1 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 KLHDC3 DDX11 WIPI1 YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP NLRP3 ESR1 NFKBIA MDM2 MDM4 GJA1 HMOX2 PKN2 STIP1 PIK3CB TCIRG1 CAPZB AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 PDPK1 PIK3CA ATP6V1B2 EPO TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 CACNA2D1 PIK3R2 ABCG2 ATP6V1H MAPK1 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MAPK3 PTPN1 CACNB1 CACNB3 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 HSPE1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN PPP2R2A RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 ATM ATR HSPA5 HSBP1 HSF1 ATP7A DEFA5 CAPNS1 CAPNS2 CAPN2 ATOX1 STOML2 PHB2 YME1L1 P2RY2 CDKN1A CDKN2A SIN3A CDK2 CTNNB1 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 ATF3 ATF4 TNRC6C MOV10 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B PSMD8 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 NUP214 DIS3 IDH1 PRKCD PSMA5 PPARGC1A PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 DCP2 PSMD12 SERP1 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 SIRT1 HSPA1A SIRT3 MMP14 PPARA CYCS SPP1 RICTOR CUL3 STAT1 TRIM21 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 HIGD1A H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KDM6B H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 NFKB1 H2AC20 HDAC3 NRIP1 COX4I1 COX4I2 TBL1X NCOA1 ARNT NCOR2 NCOR1 TBL1XR1 CRTC2 CRTC3 CRTC1 CLOCK NPAS2 HELZ2 RAI1 CHD9 TGS1 MEF2D COX7B GFPT1 COX7C EDEM1 COX8A SYVN1 COX8C INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling SOS1 SHC1 IL5 IL3RA PIK3R2 INPP5D IL2RB PIK3R1 JAK3 JAK2 JAK1 IL2RG CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 INPPL1 GAB2 PIK3R3 PIK3CA IL2RA IL5RA CSF2RB CSF2RA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex UBC TAB3 RPS27A TAB2 MAP3K7 TRAF6 UBA52 IRAK2 UBB TAB1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors HCAR3 HCAR1 HCAR2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants ERBIN HSP90AA1 ERBB2 CDC37 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor GNG13 GNB2 GNB1 GNAS GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNG10 PTGIR GNG12 GNG11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD MMACHC MMADHC DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis RIPK1 RPTOR MLST8 PIK3R4 NFKBIA ATG14 RETREG1 MTOR RICTOR BECN1 TAOK1 PRR5 DAXX NFKBIB PIK3C3 MAPKAP1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK H2AC20 ERCC6 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MYBBP1A ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs BRCC3 UBA52 H2AC20 STAM H2AC1 PSMD14 H2AC25 H2AC21 STAMBP ABRAXAS1 BRCA1 BABAM1 BABAM2 ABRAXAS2 UIMC1 UBB NLRP3 BARD1 UBC H2AC19 H2AC14 RPS27A KAT2B EP300 H2AC8 H2AC6 H2AC7 STAMBPL1 H2AC17 H2AC12 MYSM1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells KLF4 NR5A1 DPPA4 SMAD2 FGF2 SMAD4 STAT3 SALL4 POU5F1 SOX2 NANOG PRDM14 FOXD3 CRIPTO PBX1 LIN28A ZIC3 HIF3A ZSCAN10 EPHA1 EPAS1 SALL1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM KCTD6 RUNX1 ESR1 CBFB AXIN1 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors FSHR CGA GPHA2 LHB TSHB GPHB5 LHCGR TSHR GNRH2 GNRHR2 GNRH1 FSHB GNRHR DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands DLL1 SIN3A BDNF CRH HDAC1 SST SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 NTRK1 STAT3 NGF NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 PDYN POMC GNGT2 GNG10 OPRM1 GNG12 GNG11 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 CD9 ZP3 ZP2 ZP4 HVCN1 SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors LPAR4 GPR17 P2RY12 P2RY6 P2RY13 P2RY10 P2RY2 P2RY11 P2RY14 P2RY1 P2RY4 LPAR6 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 FGF9 NRAS FGF20 HRAS FGF23 FRS2 PTPN11 FGF16 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB PDPK1 AKT2 THEM4 TRIB3 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMA5 LAMA2 DRP2 DMD LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 UTRN SNTG2 DAG1 SGCE SGCD AGRN SGCA SGCB SGCG SNTA1 SGCZ DTNA DTNB SSPN SNTB1 SNTB2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBC GBP1 RPS27A UPK1A EPCAM UBA52 HBB GBP2 GBP6 UBE2D2 GBP4 HBA2 CASP4 CALM3 CALM2 CALM1 UBB TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TRAF2 LTA TRAF3 TNFRSF12A TNFSF12 MAP3K14 BIRC2 TNFRSF13C TNFRSF11A BIRC3 CD40LG LTBR LTB TNFSF13B TNFSF11 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression RXRA NCOA2 SERPINE1 NCOA6 SMARCD3 TBL1X CARM1 BMAL1 NCOA1 CLOCK NPAS2 HELZ2 CREBBP BHLHE40 CHD9 BHLHE41 NAMPT KLF15 TBL1XR1 AVP NOCT MED1 TGS1 F7 BMAL2 PPARA REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors SFN YWHAZ FOXO6 FOXO3 FOXO1 AKT1 AKT2 FOXO4 YWHAQ YWHAG YWHAB AKT3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation MET HGF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency ACAT1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis CHST2 B4GALT4 CHST3 B3GNT3 ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 PRELP CHST6 OMD KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis PPIA BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol DDX21 NOP56 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 PELP1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 DDX49 RPS28 DDX47 RPS29 WDR3 FCF1 RPS20 FAU RPS21 PWP2 RPS24 RPS27 RPS23 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 RPP30 UTP25 HEATR1 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 RPP38 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 RPP21 UTP4 RPP25 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 RPP40 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPP14 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L DIS3 RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EBNA1BP2 EXOSC7 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E NOB1 EXOSC4 RIOK2 RIOK1 TEX10 SENP3 EXOSC9 MTREX GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 NCL PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines DHFR SLC46A1 SHMT1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 MTHFD1L MTHFD2 SHMT2 MTHFD2L SLC25A32 FOLR2 SLC19A1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins APBB1IP SOS1 TLN1 FN1 SRC RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate TBX6 POU3F1 WNT3A ZEB2 SOX2 FGF8 ZNF521 SOX1 GBX2 OTX2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD PRELP OMD KERA ACAN OGN ST3GAL3 LUM GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XRCC1 POLE4 CUL4A RPA3 PPIE POLE2 POLE3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex H2BC9 H2AZ2 H4C9 H2BC8 BCL9L H2BC5 RUVBL1 H2BC3 H3-4 PYGO1 TCF7L2 H2BC1 BCL9 PYGO2 TCF7L1 HDAC1 H2AC20 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 ASH2L MYC TRRAP DPY30 WDR5 CDC73 AXIN2 LEO1 RBBP5 KAT5 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 TERT EP300 H3-3B MEN1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 SMARCA4 RUNX3 H2BC13 H2BC14 TLE3 H2AJ H2BC15 H2BC11 H3C15 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF NTRK3 LRRC4B IL1RAPL2 PPFIBP1 PPFIBP2 PPFIA1 PPFIA4 SLITRK3 PPFIA3 PPFIA2 SLITRK5 SLITRK2 SLITRK1 IL1RAPL1 SLITRK4 SLITRK6 PTPRD DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA ABAT ALDH5A1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 MAPK14 GNG7 GNA11 GNGT1 GNG8 GNGT2 GNG10 P2RY1 PLA2G4A GNG12 GNG11 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones DUOX1 TPO TPH2 IYD ASMT DUOXA1 CGA AANAT DUOXA2 DUOX2 TSHB PNMT DDC TH DBH DIO1 TPH1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy ACY1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) GUSB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) GRM8 TAS2R4 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GABBR2 TAS2R50 GABBR1 TAS2R19 TAS2R42 TAS2R45 TAS2R40 TAS2R60 TAS2R41 TAS2R43 CASR TAS2R46 TAS1R2 TAS1R1 TAS1R3 TAS2R30 TAS2R7 TAS2R31 GRM1 GRM5 TAS2R38 TAS2R8 TAS2R39 TAS2R20 GPRC6A TAS2R9 GRM3 GRM2 GRM4 GRM7 TAS2R1 GRM6 TAS2R3 TAS2R5 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER ACTR5 RAD23A YY1 ACTR8 RUVBL1 RAD23B PARP1 CETN2 UBA52 INO80 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ACTB UBB TFPT ACTL6A UBC RPS27A DDB2 PARP2 DDB1 COPS7B XPC COPS7A CUL4A COPS3 RBX1 COPS6 COPS5 MCRS1 NFRKB COPS8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations DAG1 POMT2 POMT1 POMGNT1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling ERBIN HSP90AA1 ERBB2 CDC37 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling YWHAZ SOS1 CRK STAT5A STAT5B SHC1 IL5 LYN IL3RA PIK3R2 CBL INPP5D IL2RB PIK3R1 TEC BLNK JAK3 JAK2 PRKACA JAK1 IL2RG PTPN11 CSF2 PIK3CB RAPGEF1 PIK3CD PTPN6 IL2 YES1 HCK IL3 SYK FYN INPPL1 GAB2 PIK3R3 CRKL PIK3CA IL2RA IL5RA VAV1 CSF2RB CSF2RA EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation EEF1B2 EEF1A2 RPL4 RPL5 RPL30 RPL3 EEF1G RPL32 RPL31 RPLP1 EEF1D RPL34 RPL10L EEF1A1P5 RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DBT DLD REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL CRIPTO ACVR1B LEFTY2 ACVR2B LEFTY1 ACVR2A CRIPTO3 ACVR1C DAND5 CFC1 CER1 NODAL SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR EIF2AK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages PRL FGF10 LAMA5 FGF2 LAMA2 LAMB3 AREG LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN TGFA REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 EHMT1 SETD9 UBC RPS27A PRMT5 EP300 UBA52 MDM2 MDM4 CHEK2 TTC5 JMY SMYD2 TP53 ATM KMT5A UBB EHMT2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FZR1 BTRC PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPOP PSMD12 PSMD11 PSMD14 PSMD13 CCND1 CUL3 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 CSNK2B PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 YWHAG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 RIPK3 CASP8 MLKL WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 DVL2 CSNK2B DVL3 CSNK2A1 CSNK1E PIP5K1B CSNK2A2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling WWP1 UBC RPS27A NEDD4 UBA52 SRC UBB ITCH SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R4 GNG13 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism GYG1 GBE1 UBA52 PYGM GYS1 GYS2 PHKG1 PHKG2 GYG2 EPM2A AKR1E2 PHKA1 PHKB PHKA2 PPP1R3C NHLRC1 GAA UBB PYGB PYGL UBC PGM1 RPS27A UGP2 AGL CALM1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling GNG13 GNB2 HBEGF GNB1 GNB4 PIK3R2 GNB3 PIK3R1 PRMT1 GNB5 NRAS GNGT1 MAPK1 GNGT2 GNAT3 CCND1 SPHK1 SRF MAPK3 GNG3 ESR1 GNG2 GNG5 GNG4 GNG7 ESR2 SRC GNG8 GNAI3 NOS3 XPO1 GNAI1 GNAI2 AKT1 CALM1 HSP90AA1 EGF EGFR CDKN1B S1PR3 MMP9 STRN MMP2 BCL2 AREG AKT2 PRKCZ HRAS MMP3 ZDHHC7 PDPK1 TGFA FOS CAV2 FOXO3 ELK1 IGF1R GNG10 MMP7 PTK2 EREG PIK3CA PIK3R3 UHMK1 BTC ZDHHC21 CAV1 GNG12 EPGN AKT3 GNG11 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling PITPNA TRPC7 TRPC5 DCC TRPC6 NTN1 TRPC3 TRPC4 TRPC1 PLCG1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction NEB DMD MYH3 MYH8 MYH6 TNNI1 TNNI2 TNNI3 TMOD3 TPM4 TPM3 DES VIM ACTN3 ACTN2 MYL4 MYL1 MYL2 MYL3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TPM2 TMOD4 TTN TPM1 TMOD2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA YY1 TFAP2A VEGFA ERBB2 TFAP2B ESR1 EGFR TFAP2C CGB8 TGFA KIT ATAD2 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RBM8A PRKACG PRKACA CXCR4 PRKACB ETF1 GSPT2 GSPT1 CXCL12 UPF3A CAP1 UPF2 LDB1 VASP CAP2 ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RAC1 RPSA PRKAR2A RPS3A RPS26 RPS25 PPP3CB RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 SOS2 HOXA2 FLRT3 ZSWIM8 MSI1 LHX3 LHX2 LHX4 LHX9 COL4A5 NELL2 GPC1 PSMD8 PSMD6 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 CUL2 PSMD1 PRKCA ROBO2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ARHGAP39 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SLIT1 UBC PSMB1 SLIT3 RPS27A ADRM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABL2 EIF4G1 PAK2 PAK4 ABL1 ISL1 DCC NTN1 USP33 SRGAP3 SRGAP1 NCK2 NCK1 PFN1 PFN2 PAK6 PAK3 PAK5 MYO9B SRGAP2 NRP1 EIF4A3 RPS27 SOS1 MAGOH RPL4 RHOA RPL5 RPL30 RPL3 RPL32 RPL31 EVL RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 CDC42 RPL38 RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 CLASP1 RPL22 CLASP2 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 SRC RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 AKAP5 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 CASC3 NCBP1 NCBP2 SEM1 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g ALG12 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 PSMD1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions KDELR1 YBX1 LYN NCL FURIN CLINT1 TSG101 GBF1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L CCNT2 TAF4B ELOB ELOC CCNH POLR2A CDC73 TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 TAF15 GTF2H2 LEO1 TAF12 GTF2H3 TAF13 SUPT5H PAF1 GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 TAF10 SUPT6H IWS1 EAF1 EAF2 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair LIG1 FEN1 PARP1 PARP2 POLB PARG APEX1 ADPRS FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion GNA14 GNAQ CD36 GNA15 PLCB3 PLCB1 FFAR1 PLCB2 ACSL4 ACSL3 GNA11 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification RCC1L RPUSD4 NGRN RPUSD3 TRMT61B TRUB2 MTERF3 SLIRP MTPAP FASTKD2 LRPPRC INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 CDC42 RAC1 SRGAP2 SRGAP3 ARHGAP39 SRGAP1 SLIT2 ROBO1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 NPLOC4 POLH RPA3 VCP SPRTN UFD1 UBB DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT GALT SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis TBX6 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 LEF1 PSMD11 PSMD14 PSMD13 PSMA7 CTNNB1 PSMB6 PSMB7 PSMB4 PSMB5 MESP2 DLL3 PSMB2 HES7 PSMB3 MSGN1 RBPJ RIPPLY2 PSMB1 LFNG ADRM1 EPHA4 PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 NOTCH1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F PIK3R1 POLR2G POLR2H NRAS PLCG1 POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 PIK3CA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription CREBBP FLT4 RBPJ MAML2 MAML1 SMAD3 KAT2B HEY1 KAT2A ACTA2 HES1 SNW1 EP300 HEY2 HES5 MAMLD1 MAML3 NOTCH2 NOTCH1 NOTCH4 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RELA MAP3K7 PIK3R2 PIK3R1 NFKB1 CDC34 CHUK IKBKB CARD11 MALT1 NFKBIA UBE2D2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 TRAC PSMA2 INPP5D CD3G TRAT1 CD3E TRAF6 CD3D UBA52 TRBV12-3 PSMD12 TRAV29DV5 PSMD11 TRBV7-9 BCL10 TRBC1 PSMD14 BTRC HLA-DQA2 PSMD13 HLA-DQA1 HLA-DPA1 PSMA7 HLA-DRB5 TRAV19 PSMB6 HLA-DRB4 PSMB7 HLA-DPB1 PSMB4 TRAV8-4 HLA-DRA PSMB5 IKBKG CD4 HLA-DRB3 UBB HLA-DRB1 RIPK2 HLA-DQB2 PSMB2 PIK3CB PSMB3 HLA-DQB1 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 LCK SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 PDPK1 TAB2 PRKCQ PIK3CA UBE2N CUL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription JUN HDAC1 HDAC3 KDM1A MAPK1 MBD3 MAPK3 ATF2 EGR1 GATAD2B GATAD2A RPTOR MLST8 CHD3 SLC38A9 BMI1 CBX6 RING1 HDAC2 MTOR RNF2 RRAGA RRAGC SUZ12 CBX8 PHC2 RHEB RRAGB PHC1 NR2E1 RRAGD CBX4 CHD4 LAMTOR2 CBX2 LAMTOR1 PHC3 SNAI2 LAMTOR4 LAMTOR3 LAMTOR5 MECOM RCOR1 ATN1 EED SALL4 MAF1 HDAC5 MTA2 HDAC7 RBBP4 EZH2 MTA1 REST MTA3 RBBP7 SNAI1 TP53 PPARG CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 RXRA CYCS PTK6 COX5B COX5A STAT3 COX6C HBB HDAC3 SIN3A COX4I1 COX4I2 BLVRB TBL1X COX6A1 BLVRA NCOA1 COX6A2 FABP1 MT-CO1 NLRP3 COX6B2 COX6B1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 HIGD1C ABCC1 ALB HBA2 TXNIP HMOX1 MT-CO2 MT-CO3 HM13 HMOX2 NCOA2 NCOA6 SMARCD3 CARM1 BACH1 HELZ2 CREBBP CHD9 MAFK NFE2L2 MED1 TGS1 STAP2 COX7A2L COX7B COX7C COX8A COX8C PPARA PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNG CHRNE CHRNA6 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions ITGA3 ITGA6 ATP1B3 PPIL2 ATP1B2 ATP1B1 SLC16A8 MMP1 SPN SLC16A3 SLC3A2 SLC7A11 SLC7A10 SLC16A1 MAG PPIA BSG SLC7A5 SLC7A6 ITGB1 SLC7A7 CAV1 L1CAM SLC7A8 SLC7A9 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling TYK2 IL23R STAT4 JAK2 IL12B STAT3 IL23A IL12RB1 P4HB DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage APRT DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PFKFB2 PRKACG PFKFB1 PFKFB4 PRKACA PFKFB3 PPP2R5D PRKACB PPP2R1B PPP2R1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RHOC H2AC20 RHOA RHOB KDM1A PPP1R12B PPP1R14A KLK3 KLK2 KDM4C YWHAB YWHAE MYL9 YWHAQ YWHAG AR YWHAH PKN3 YWHAZ SFN NCOA2 CDC25C PKN2 PKN1 PPP1CB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 PPP1R12A H2AC6 H2AC7 PAK1 RAC1 H2BC17 MYL12B H2BC12 MYL6 H2BC13 MYH9 H2BC14 MYH14 H2AJ MYH11 PDPK1 H2BC15 MYH10 H2BC11 H3C15 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis UBC PGM1 GYG1 RPS27A GBE1 UBA52 GYS1 GYS2 UGP2 GYG2 EPM2A PPP1R3C NHLRC1 UBB APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC16 ANAPC7 UBE2C UBC UBE2E1 UBE2D1 RPS27A ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC20 UBB ANAPC15 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions CACNA1D NCAM1 COL4A2 GFRA1 COL4A1 GFRA2 GFRA4 NRTN CACNA1C CACNA1S PSPN COL6A2 COL4A4 COL6A1 GDNF COL4A3 CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 CNTN2 COL6A6 COL9A2 ST8SIA4 COL6A5 AGRN NCAN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PRNP ARTN GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP5 YWHAZ GP9 RAF1 PIK3R1 VWF FLNA GP1BA GP1BB SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol RXRA ACOX2 ABCB11 NCOA2 AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 ACOT8 BAAT HSD3B7 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall IGHV3-23 IGLV IGLV2-8 SELP IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 SLC16A8 IGKV1D-39 PECAM1 SLC16A3 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SLC16A1 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 APOB IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 IGLC1 PPIL2 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MMP1 IGKV1-33 SLC3A2 IGLC7 SLC7A11 IGHV3-53 SLC7A10 EPCAM IGKV5-2 IGLC6 IGKV1-5 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 SDC1 LYN INPP5D DOK2 GP6 PF4 MIF PPIA CAV1 ITGA3 JAM2 ITGA6 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 OLR1 SPN VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 PSG9 FCAMR PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD ANGPT4 ANGPT2 MERTK CD2 CD244 PLCG1 ITGAM ITGB2 PIK3CB F11R HRAS SIRPG GRB7 PIK3CA ITGB3 ITGB1 L1CAM ITGAV ITGA5 SOS1 TNFRSF10B SHC1 TNFRSF10A PIK3R2 PIK3R1 TNFRSF10D NRAS ITGAX FCER1G ITGAL CEACAM3 CEACAM6 PTPN11 CEACAM8 CD47 TSPAN7 CD44 ITGA4 CD58 PICK1 SIRPA SELL TREM1 PTPN6 CEACAM1 YES1 LCK FYN PROC BSG PROS1 F2 IGHA1 GAS6 IGHA2 JCHAIN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 SOS1 NCK2 SOS2 NCK1 SLIT2 ROBO1 PAK6 PAK1 PAK3 RAC1 PAK5 PAK2 PAK4 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling ACVR2A INHBA INHA TGFBR3 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling PTPN7 PTPN5 IL18R1 PTPN2 PTPN4 SIGIRR SMAD3 STAT3 TBK1 PTPN6 PTPN13 PTPN20 PTPN23 IL18BP CASP1 PTPN18 IL37 PTPN12 PTPN11 PTPN14 PTPN9 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle ERBIN MPP7 VANGL1 ARHGAP32 RHOG ARHGEF5 PIK3R1 ESYT1 ARHGEF26 KALRN ELMO2 MCF2 CDC42 DOCK5 DOCK4 ARHGDIG ANKLE2 DOCK3 ARHGDIA SHMT2 LAMTOR1 NDUFS3 CYFIP1 DOCK2 DOCK1 TFRC PLD1 IQGAP2 STX5 ARHGAP1 HSPE1 ARHGAP39 LETM1 ARHGAP5 ARHGAP35 OPHN1 STBD1 ARHGDIB MAP3K11 EMD LBR TMPO PLEKHG3 VRK2 LEMD3 DEPDC1B ARFGAP3 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO ITSN1 ARHGAP21 PREX1 LMAN1 MCF2L PGRMC2 NDUFA5 VAV3 VAPB KTN1 PAK2 YKT6 ARHGEF16 PAK4 DIAPH3 ITGB1 VAV1 VAV2 CAV1 MCAM REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 SIN3A RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RELA DDX5 NPM1 ITCH VCP NLRP3 ACE2 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 MAVS TKFC RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI PARP10 PARP6 SFTPD GSK3A PARP4 PARP16 YWHAQ PARP9 PYCARD PARP14 YWHAG PARP8 YWHAH UVRAG MAP1LC3B PPIB TRAF3 TRAF6 RB1 BECN1 TLR7 RIPK3 TMPRSS2 RPS4Y2 KPNB1 RPS27L GALNT1 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C HNRNPA1 RPS10 CHMP4B EP300 RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RUNX1 CHMP2B RPS3A RPS26 CHMP2A EEF1A1 RPS25 RPS28 RPS29 PDPK1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PIK3C3 CHMP3 CHMP6 CHMP7 PIK3R4 NFKB1 BST2 PRKCSH GANAB MGAT1 MOGS PCBP2 CANX UBE2I SUMO1 YWHAB FKBP1A ST6GALNAC2 TRIM25 CASP1 IKBKE SIKE1 VHL GSK3B ST6GAL1 SFN YWHAZ UBA52 ST6GALNAC3 ST6GALNAC4 IFIH1 UBB TOMM70 UBC SP1 ST3GAL4 RPS27A BCL2L1 ZCRB1 ST3GAL1 ST3GAL2 ST3GAL3 PPIA IRAK2 PSMC6 KPNA2 CTSL PPIH PPIG CAV1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals DCC UNC5A NTN1 UNC5B SRC UNC5C PTPN11 UNC5D REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBC RPS27A TICAM1 TLR3 TBK1 TRAF3 IKBKE OPTN UBA52 TANK UBB PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy MAP1LC3A VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN TOMM40 UBE2D2 UBE2D3 MTERF3 PINK1 UBE2N VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism FASN PDZD11 SLC5A6 PANK4 VNN1 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP1 ENPP2 ENPP3 SLC25A42 AASDHPPT RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking RAB14 RAB27B TRAPPC4 RAB9A RAB6B RAB9B RAB39A YWHAE MAP1LC3B RAB33B RAB31 RAB5B RAB5C RAB3IP RAB11A RAB6A ARF6 RAB1A TRAPPC1 RAB1B RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 SYTL1 GAPVD1 RIC1 RAB32 RAB35 TBC1D24 RGP1 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB3GAP2 TRAPPC2L DENND6A RAB10 RIN1 TBC1D20 RIN2 RAB3GAP1 GABARAP TBC1D13 RAB18 TBC1D14 TBC1D17 TRAPPC2 TBC1D15 TBC1D16 TRAPPC3 ANKRD27 TBC1D10C DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B TRAPPC8 MON1A MON1B TRAPPC6A DENND1C TRAPPC6B DENND1B GDI1 ULK1 DENND1A RAB8B DENND2D TRAPPC10 DENND2C DENND2B DENND2A RAB3IL1 RAB33A TBC1D2 GDI2 RABEP1 TBC1D3 TBC1D7 RAB7B RABGAP1 DENND3 RAB21 ALS2CL CHML RAB11B RAB12 RAB13 CHM GGA2 GGA1 GGA3 TSC2 TSC1 AKT1 ALS2 RAB3A RAB4A RAB7A OPTN RAB27A RAB8A AKT3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation EOMES FGFR1 SNAI1 TBXT SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2BC9 H2AZ2 H4C9 H2BC8 TBP TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 RRP8 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 H2BC11 H3C15 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters POLRMT TFAM MTERF1 TFB2M G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC RBBP4 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism ENO1 PGK1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal MGMT ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 FBXO5 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis FAR2 AWAT1 AWAT2 FAR1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases YY1 RUVBL1 H2AC20 TGFB1 H2AC1 TGFBR1 TGFBR2 KDM1B INO80C INO80B INO80E INO80D SMAD7 OGT PSMD8 PSMD6 H2AC17 H2AC12 PSMD7 PSMD2 PSMD3 NFRKB SENP8 PSMD1 HCFC1 ACTR5 PSMA5 PSMA6 PSMA3 ACTR8 PSMA4 PSMA1 PSMA2 UBA52 INO80 PSMD12 PSMD11 PSMD14 H2AC25 H2AC21 USP15 PSMD13 BAP1 PSMA7 PSMB6 FOXK2 PSMB7 UCHL1 FOXK1 PSMB4 PSMB5 ACTB UBB TFPT PSMB2 ACTL6A PSMB3 BARD1 UCHL3 UBC H2AC19 PSMB1 UCHL5 H2AC14 RPS27A ASXL1 NEDD8 ADRM1 H2AC8 ASXL2 H2AC6 PSMC5 H2AC7 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MBD5 PSMC2 MBD6 MCRS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling JUN IGF2BP1 MAPK6 MAPK4 KALRN DNAJB1 PRKACG PRKACA PRKACB CDC42 TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B HSPB1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 NCOA3 PSMA2 CDC14A UBA52 PSMD12 PSMD11 CDK1 CCND3 PSMD14 PSMD13 MAPKAPK5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDC42EP5 RPS27A CDC42EP3 CDC42EP2 FOXO1 ADRM1 PSMC5 PAK1 PAK3 PSMC6 RAC1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SEPTIN7 CDC14B FOXO3 PAK2 RAG2 RAG1 ETV4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFB105B DEFA1B DEFB1 DEFB104B DEFA6 DEFB109B DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 CCR6 DEFB133 DEFB132 PRSS3 DEFB108B DEFB108C PRSS2 CCR2 CD4 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC TP53 ARG2 SLC25A2 SIRT5 SLC25A15 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling TAS2R10 TAS2R13 TAS2R14 ADCY9 TAS2R16 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A ITPR1 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP TAS2R38 PDE11A PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 GPR183 PNOC GPR18 SSTR3 PTH1R GPR37 PDE10A GPR31 PTH2R GPHA2 GNAS GPR55 GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 TAS2R42 TAS2R45 CRHR1 PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW TRIO RASGRF2 ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 VAV3 HCAR1 ARHGEF11 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ ARHGEF15 PLEKHG5 HEBP1 ARHGEF17 GRM3 ARHGEF16 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A AGT GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP APP F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 RGSL1 GRPR CYSLTR1 CCL1 EDNRA CCL19 EDNRB PROK2 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 GPR17 ACKR3 NMB CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK ADORA1 HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HBEGF HRH2 HRH4 DRD1 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA PAK1 C3 ROCK1 ROCK2 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology NR5A1 CLTB YAP1 RELA WNT1 PERP ARPC1B ARPC1A ARPC4 ARPC5 MAMLD1 SLC2A2 ARPC2 ARPC3 IHH ACTR3 ACTR2 CNOT10 CNOT11 TCF3 YWHAE LDB1 LEP DPY30 CHD4 YWHAG CSF1 YWHAH EED MTA2 CARM1 DAG1 MMP2 MAML2 MAML1 TRIO ITSN1 MED1 RAC1 MED8 VAV3 ARHGEF11 MED4 ARHGEF12 MED6 MED7 PRKCQ MAML3 CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 NKX2-5 ARHGEF7 SOS2 NGEF KALRN RET RARG ASH2L TFAP2A TFAP2B TFAP2C UBE2I TNKS1BP1 SUMO1 TEAD1 TEAD2 TEAD4 HIF3A ELOB TCF12 ELOC RBX1 RARB AJUBA EPAS1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C POLR2A PLXNA3 POLR2B LCE1A POLR2C LCE1B POLR2D LIPJ POLR2E LIPN POLR2F LIPM POLR2G PRSS8 POLR2H LIPK POLR2I POLR2J KRT4 POLR2K KRT3 POLR2L KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ACTB LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL CSNK2A1 KRT33B KRTAP5-10 KRT33A CSNK2A2 KRTAP5-11 SPRR2A SPRR2B SPRR2D CSNK2B ST14 CDSN KRTAP16-1 KRTAP8-1 TP53 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 SOX17 KRT27 SRY KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 ABL1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 PLAC8 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A PLXNA4 MAP2K6 KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B CNOT4 KRTAP2-4 CDK8 KRTAP2-3 KRTAP2-2 CNOT6 KRTAP2-1 CNOT7 KRT13 KLK13 CDK5 CNOT1 KRT12 KLK14 CNOT2 CNOT3 KRT10 LCE3E KLK12 KRT19 CNOT8 KRT18 KRT17 CNOT9 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 WDR5 KRT6C KRT6B RPTN ZNF521 KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 KRT76 SMARCD1 KRT75 SMARCD2 KRT74 SMARCD3 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 RBBP4 KRTAP23-1 RBBP5 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PTPRC LELP1 RBBP7 KRTAP4-1 ACTG1 KRTAP12-1 KRTAP12-3 KRTAP12-2 SMARCE1 KRTAP4-9 KRTAP4-8 KRTAP12-4 KLF4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 PFN1 KRTAP11-1 CELA2A SOX2 PFN2 KRTAP5-9 KRTAP5-8 KRTAP5-7 NFASC KRTAP5-6 KRTAP5-5 KRTAP5-4 SOX9 KRTAP19-2 KRTAP19-1 RUNX3 SRGAP2 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DIAPH1 DSG4 RPS27 KRT82 KRT81 ITGB1 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 RHOC KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 RHOA KRTAP6-3 RHOB KRTAP21-1 EVL SRF CDK5R1 CDC42 COX7A1 CLASP1 CLASP2 KDM5B ARID1A ARID1B TYROBP IFNG ERBB2 HES1 POMC MARK3 MMP9 NCBP1 NRP2 NCBP2 TLN1 CNTN2 NRCAM ANK1 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 FYN POU3F3 WNT4 MCM5 MCM2 CLTC CYP51A1 SREBF2 CLTA AP2A1 VLDLR AP2A2 CDON AP2M1 PBX1 RAP1GAP PRKACG PRKACA PRKACB CCL3 ANGPTL4 LPL AP2S1 CXCL12 DICER1 AP2B1 TRPM1 PAX3 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP LAMA5 LAMA2 SH3KBP1 PXN LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NUMB UCP1 MTA1 PRDM16 ZNF423 ENAH MTA3 RPS4Y2 EBF2 RPS27L BMP7 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 GMPR RPS3 MYO10 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 PPP3CB RPS25 MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 WNT11 NOTCH1 CACNA1D GCK NFATC1 NANOG HSP90AB1 RDX NAB1 NAB2 DNM2 SIAH1 EGR2 EPRS1 ID1 EIF4E ID4 EIF4B ZFPM2 EPHB6 EFNB2 ARHGAP39 EFNB1 EFNB3 EPHB2 EPHB1 ARHGAP35 EPHB4 EPHB3 ITGA10 FOXH1 ACVR1B WNT3A ACVR2B GIT1 ACVR2A DRAP1 ACVR1C DSG2 EPHA2 PAK1 ABL2 PAK2 PAK4 POU5F1 TGFB1 CNTN1 FOXC2 FOXC1 SIX1 HOXD11 NPNT HOXC11 HIRA PAX2 HOXA11 GREM1 SALL1 SIX2 DSCAM DCC DSCAML1 NTN1 STX1B TNFSF11 SRGAP3 SRGAP1 JUP FGFR1 WASL IAPP PAK6 PAK3 PAK5 MYO9B TPST2 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 SERPINE1 RPL4 RPL5 RPL30 RPL3 ITGA2 RPL32 RPL31 RPLP1 ITGA8 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 CTCF RPLP2 FABP4 HOXA3 RPL35 COL9A1 RPL38 HOXA1 PKNOX1 COL9A3 RPL37 PRL COL9A2 HOXA4 AGRN PIAS2 RPL39 RPL21 HOXB4 CHD3 RPL23 HOXB3 RPL22 HOXB2 HOXB1 RPL13A HOXD1 RPL9P9 HOXC4 RPL37A RPL24 MEIS1 RPL27 MAFB RPL26 HOXD4 HDAC2 DPF1 RPL29 HOXD3 RPL28 ZNF335 DPF2 RPL10 RPL12 DPF3 RPL11 RPL36A SUZ12 RPL14 PAXIP1 RPL13 RPL15 RPL18 RPL17 RPL19 PCGF2 RPL39L SS18L1 RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 CD36 NCOA2 SS18 NCOA6 NCOA3 TET3 SHH DHH ADIPOQ CREBBP EYA1 BCL2 NTN3 AREG CDH4 BNIP2 TNF CTNNA2 MYOG EBF1 WNT10B SPAG9 MEF2B NR2F2 MYOD1 ADIRF PAGR1 MYF6 SLC2A4 ZNF638 TCF4 BCL7A CEBPD CDH15 ZNF467 BCL7C MYF5 BCL7B FOXA1 KDM6A TGFA FOXO3 ABLIM1 ABLIM2 PTK2 ABLIM3 AKT3 JUN MED19 UHRF1 MED18 MED11 MED9 MED29 MED28 MED22 MED21 CDK19 MED13L ETF1 GSPT2 GSPT1 ASAH1 GSC MIXL1 UPF3A UPF2 UNC5A UNC5B CIDEA CAP2 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 MC4R DARS1 EEF1E1 MC3R KARS1 IARS1 PKP1 MC5R SDCBP DSP DSG1 DSG3 MAPK7 APH1A ZIC1 FOXD3 PSENEN NCSTN TFE3 APH1B MITF CLTCL1 PSEN2 TFEC ADAM10 ALX3 TBX3 PSEN1 DNM1 SDC2 STT3B GPC1 MAG PRDM14 CRIPTO SHC3 LIN28A ZIC3 ZSCAN10 DNM3 MAPK12 GATA3 LYN SIAH2 RPLP0 PITPNA CFL1 STAT4 IL12RB2 ACTL6A MSN PIK3CD KAT2B KAT2A MEF2A FGF8 RPS6KA3 SOX1 GBX2 RPS6KA5 RPS6KA2 OTX2 TBX6 RPS6KA1 POU3F1 YY1 ITGA1 LEFTY1 CRIPTO3 ONECUT3 DAND5 ONECUT1 CFC1 CER1 PDX1 NKX6-1 NODAL PTF1A PAX6 ISL1 PTGDS FOXO4 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD1 SMAD4 SMAD3 NEUROG3 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 USP33 SNAI2 FOXA2 NEUROD1 NKX2-2 PAX4 HNF1A MAFA RFX6 INSM1 FOXA3 FARP2 PLXND1 PKP4 PLXNA1 IRS2 PIK3CB PLXNB1 FGF2 NCK2 FGF4 NCK1 FGF7 MESP1 FGF9 AKT2 GATA6 TBXT GRB10 ATP6V1E1 TBX20 SMYD1 TBX1 EOMES HRAS ATP6V1G1 MYOCD HAND1 ATP6V0B ATP6V0E1 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 HNRNPU SPTBN1 ATP6V0D1 SOS1 ATP6V0C MAGOH ATP6V1A SHC1 PIK3R2 PIK3R1 INS NRAS ATP6V1H MAPK1 ATP6V1C1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 FGF10 UPF3B MAGOHB SNW1 SRC RNPS1 SHANK3 GRIN2B THRAP3 GRIN1 RND1 DLG1 DLG3 TBPL2 DLG4 MBP EMX2 FAM120B ADGRV1 PCDH19 DOCK1 WFDC2 MECOM MSX1 MPZ OSR1 PLK1 ADGRG6 ZIC2 HMGCR TBX21 SALL4 CCNB1 HOXA6 PAX8 PAX7 AMH GDF1 PRX NOG CTNNA1 DMRT1 NOTO PMP22 FOXF1 SOX10 BRCA1 ZEB2 CASC3 SNAI1 RANBP9 KAT5 GXYLT2 CDH2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP CEACAM1 ZEB1 DCT IRF4 SEM1 PXDN BIRC7 BCL2A1 TYRP1 MLANA USF1 MLPH RBM8A CXCR4 EDNRB KIF4B KIF4A CAP1 EDN1 EDN3 LEFTY2 PABPN1 PI3 CAPNS1 CAPN1 SCD5 ELOVL3 KIT BMP4 TCF7L2 CDKN1A ALCAM TCF7L1 SCN11A HDAC1 HOXA2 CDKN2A UNC5C LEF1 UNC5D TCF7 CDC25B SCN10A AGAP2 TBX2 FLRT3 HINT1 CCND1 CHL1 LYPLA2 SIN3A ZSWIM8 CDK2 MSI1 CTNNB1 COL6A2 MET PLXNC1 SEMA6A COL4A4 SEMA6D CEBPB SEMA7A COL6A1 GPR143 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 LHX4 COL6A3 LHX9 RBPJ CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB TNRC6C COL6A5 MOV10 NTN4 STX1A SEMA3E MEF2C AGO3 SEMA4A AGO4 NELL2 CDH1 RPS6KA4 SCN1B MYC AGO1 SCN1A AGO2 EPHA5 EPHA4 TNRC6A EPHA7 TNRC6B EPHA6 YWHAB EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 XPO1 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B AKT1 SCN3A PSMD1 PRNP SPTBN2 GATA4 ARTN CD24 SCN2A SCN2B PRKCA ROBO2 YWHAZ GFRA1 PSMA5 GFRA3 PPARGC1A PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 RGMA PPARGC1B PSMA1 GFRA4 RELN PSMA2 CD72 SCN9A PABPC1 NRTN DOK2 UBA52 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C EFNA5 PSMD13 EFNA4 SPTA1 EZH2 PSMA7 CACNA1S PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX MED16 PSMB2 SCN4A MED15 PSMB3 SCN4B MED17 SLIT1 SCN7A UBC MED12 PSMB1 SLIT3 MED14 PDLIM7 MED13 RPS27A HEY1 MED10 HSPA8 HEY2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 CACNA1H PSMC2 MYL12A MED27 SIRT1 CACNA1G MED26 CACNA1I EIF4G1 MED23 MED25 MED24 MED20 PPARG PPARA DRP2 FURIN PCSK6 ROCK1 ROCK2 UTRN MBD3 GATAD2B GATAD2A NCAN RPS6KA6 HSP90AA1 EGF EGFR PLCG1 CCND3 E2F1 TFDP1 TFDP2 CDK4 KMT2D H2AX CSF3R SPI1 GFI1 LIG1 H2AB1 DLX5 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 FOXO1 DOK1 MYB EP300 IL6R RASA1 H3-3B H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 BTG4 RUNX1 EIF4A2 H2BC12 H2BC13 KDM5A EIF4A1 H2BC14 TUT7 H2AJ TUT4 H2BC15 DUX4 TAL1 H2BC11 PABPN1L RARA TPRXL DUXA CEBPA KMT2A DUXB DIS3L2 CBFB CEBPE KDM6B GATA2 PRM2 H3C15 PRM1 RXRA STPG4 H2BC9 METTL23 H2AZ2 DPPA4 DPPA3 H4C9 H2BC8 DPPA2 H2BC5 ZFP36L2 H2BC3 LEUTX STAT3 PAIP1 NPM2 H2BC1 NFKB1 KDM4E DEK FLI1 TPRX1 AICDA KLF5 H2AC20 SRPK1 H1-8 TPRX2 HDAC3 ZSCAN4 TBL1X PCK1 NCOA1 NCOR2 NCOR1 HAND2 TBL1XR1 SLIT2 PLIN1 ROBO1 SEMA5A AKAP5 TBX5 CACNG8 CACNG2 CACNG3 CACNG4 TRIM33 SMARCB1 CCNC SMARCC1 SMARCC2 HELZ2 CHD9 ST8SIA4 TFEB SH3GL2 WWTR1 YES1 TGS1 MEF2D SMARCA2 SMARCA4 ST8SIA2 HNF4G DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 MAN1B1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR SOS1 HBEGF SHC1 ARHGEF7 PIK3R1 NRAS STAM2 ADAM10 ADAM12 PTPRK EPS15L1 EPN1 PTPN11 SPRY1 PTPN3 CDC42 FAM83B ADAM17 SRC LRIG1 SH3KBP1 PXN EGF CBL EGFR UBA52 PLCG1 STAM CSK HGS PTPN12 UBB PAG1 UBC RPS27A FAM83D SH3GL3 AREG FAM83A EPS15 SH3GL2 SH3GL1 AAMP SPRY2 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV GYG2 GBE1 GYS2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication ORC4 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 CCNB1 RB1 CDK1 PPP2R3B E2F1 MCM8 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B ORC5 POLA2 PPP2R1A NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway RXRA NR5A1 NR2C2 PPARD NR2C1 NR2C2AP RXRG NR2F1 NR0B2 NR2F6 NR1D2 RXRB NR1D1 ESRRA RARG ESRRB ESRRG NR1H2 NCOR2 NCOR1 ESR1 VDR ESR2 HNF4A MED1 NR4A2 NR4A1 RORC THRB RORA THRA RORB NRBP1 HNF4G NR2E1 RARB RARA PGR PPARG AR PPARA RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME SLC29A1 ADK SLC29A3 NME1 NT5C2 SLC28A3 NME2 PNP ITPA ADA SLC28A2 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PLD6 PLD2 PLD1 PLD3 PGS1 CDS2 PTPMT1 PLD4 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle FAM169A ADD3 AKAP12 SNAP23 VANGL1 ARHGAP1 ARHGAP32 SLC4A7 ARHGAP39 PIK3R2 ARHGAP5 PIK3R1 RHOF ESYT1 SYDE1 BAIAP2L1 ACTN1 POTEE LMNB1 TMPO BASP1 ACTB TOR1AIP1 ARHGAP12 DEPDC1B CAPZB VAMP3 RAB7A STEAP3 DIAPH2 ARHGAP21 SOWAHC FARP1 MYO9B SRGAP2 MTMR1 BAIAP2L2 SENP1 DIAPH1 DIAPH3 CAV1 MCAM DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology ASH2L NCOR2 NCOR1 TBL1XR1 HDAC1 HDAC3 CAMK4 GPS2 SIN3A RBBP5 PRKACA DPY30 TBL1X WDR5 CALM1 KMT2D IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly UQCRFS1 BCS1L UQCRH LETM1 TTC19 UQCRHL FXN LYRM4 HSCB LYRM7 UQCRC1 UQCRC2 UQCC3 UQCC2 UQCC1 CYC1 UQCC6 UQCC5 UQCR11 UQCR10 UQCRQ HSPA9 UQCRB MT-CYB RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 RRN3 CBX3 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 MBD4 MPG SMUG1 OGG1 NTHL1 APEX1 TDG REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 HEYL SPCS3 SPCS2 SPCS1 ANGPTL4 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRDM8 CTNND1 UBA52 BHLHE22 CDH8 PSMD12 ZC3H12A PSMD11 CTNNA1 PSMD14 CDH24 HOXC8 PSMD13 FOXF1 CSNK2A3 ADAM33 SOX10 EZH2 PCSK7 PSMA7 ADAM19 ILF3 PSMB6 MPHOSPH8 ZEB2 CDH11 PSMB7 SNAI1 CDH19 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity NR3C1 ESRRA STAT1 NKX3-2 MSX2 ESR1 SMURF1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B PSMA5 STUB1 PSMA6 PPARGC1A PSMA3 PSMA4 PSMA1 PPARGC1B PSMA2 UBA52 PSMD12 PSMD11 PSMD14 WWP1 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DLX5 PSMB1 DLX6 RPS27A HIVEP3 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TWIST1 CBFB CUL1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT GPAA1 PLAUR PIGK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 TPMT MTR AS3MT MAT1A NNMT MTRR COMT CYP1A2 MAT2B HEMK2 MAT2A GSTO1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle APBA1 SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 CASK LIN7A LIN7C LIN7B TSPOAP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L POLRMT GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB AJUBA ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ACTB ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ANG AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 PSIP1 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 GTF3C1 ARID1A GTF3C2 ARID1B GTF3C3 RBL2 GTF3C4 RBL1 CRCP IFNG GTF3C5 ZNF197 GTF3C6 ZNF195 BRF1 NR2C2 POLR3GL NR2C1 POLR3A THBS1 POLR3B HSPD1 VEGFA POLR3C ERBB2 POLR3D HES1 GLS2 POLR3E ZNF189 POLR3F ZNF286A POLR3G ZNF184 POLR3H ZNF180 BDP1 OPRK1 GLS POLR3K ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 BCDIN3D CDK9 TCEA1 XPO5 DROSHA JAG1 MTERF1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ANGPTL4 LPL TSNAX PRKRA DICER1 TARBP2 TSN SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A TRPC3 MTA1 MTA3 ELAC2 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAN LBR CAV1 TGFB1 STEAP3 ITGA2B TDG ITGA5 SERPINE1 LIPE DGAT2 FABP4 CHD3 BMI1 LPIN1 SUMO2 MGLL RING1 RRP8 HDAC4 SAP130 HDAC2 DPF1 L3MBTL2 PDK4 DPF2 SATB2 KAT8 RNF2 DPF3 SAP30BP HCFC2 SUZ12 WDR82 CBX8 PAXIP1 PHC2 PEX11A PHC1 BAZ2A CBX5 KAT14 CBX4 PCGF2 SETDB1 SS18L1 CBX2 SMARCA5 PHC3 ZZZ3 GSK3B TADA2A ZNF816 EZH1 AXIN1 PHF1 SUV39H1 GPI SGF29 CD36 CDC73 JARID2 NCOA2 SS18 NCOA6 NCOA3 TET2 SKIC8 TET1 PPHLN1 BAZ1B PHF20L1 CTR9 RTF1 NR5A2 AEBP2 MTF2 TET3 LEO1 PLIN4 PAF1 PLIN2 MBD2 MYBBP1A MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 SP1 TASOR MBIP TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C BCL7B CAMK4 DNMT3B UBTF BDNF ZNF765 KDM6A TGFA DNMT3A FOS POLR1A FOXO3 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H AKT3 C19orf84 JUN ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP ERCC6 RRN3 CIDEC HCFC1 AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X MCRS1 YY1 USP7 NFIX SSB USP2 NFIA NFIB NFIC FOXO4 ATXN3 SUDS3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 TADA3 MDM2 MDM4 OGT PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 TFAM TFB2M CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP PLD6 MAPK1 CAVIN1 CSTF3 CSTF2 DDX4 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S SF3B1 CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 IPO8 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 MTREX RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 PIWIL2 TDRKH SNRPB SRSF9 PIWIL1 HENMT1 RBM8A ASZ1 MAEL MOV10L1 MYBL1 CPSF4 TDRD9 CHTOP TDRD6 TDRD1 TDRD12 CPSF1 FKBP6 ALYREF CPSF3 CPSF2 YBX1 RBM7 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SAP18 MORC2 GTF2A1 GTF2A2 GTF2B ACSL1 ELOVL5 GTF2E1 GTF2E2 KIT SCD TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 HSP90AA1 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 CEBPA KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L NCOA1 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 PLIN1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 PCBP4 TP53 CDKN1A ZNF385A MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation MT-ND6 COX5B MRPS10 COX5A MT-ND5 MT-ND2 MRPL32 MT-ND1 ECI1 PCCB SUCLG2 UQCRC2 PRKACA MRPS2 OGDH MT-ATP6 STAR FH SHMT2 TRIAP1 ATP5PF ATP5PD MRPL12 MDH2 ATP5F1C ATP5PO NDUFA13 SLC25A5 SLC25A6 HSD17B10 SPG7 AFG3L2 SMDT1 YME1L1 PMPCA NDUFV3 ATP5MG MICU2 NDUFV1 STARD7 IDH2 UQCRQ TFAM HADH OMA1 OPA1 ALDH1B1 ME2 IDH3A BDH1 OXCT1 HMGCS2 PRELID1 ACAT1 NDUFS1 CHCHD2 NDUFB6 COX4I1 IARS2 ARG2 MT-CO1 HTRA2 ECH1 ACOT2 NDUFA2 LONP1 TWNK SSBP1 LDHD MT-CO2 NDUFS3 CS HSPD1 ACO2 PDHB GLUD1 TIMM17A PDK1 PDHA1 TIMM22 HSPA9 OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 ALAS1 TIMM9 TIMM10 ATP5F1A ALDH2 ATP5F1B DBT DLD PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy SQSTM1 UBC MAP1LC3B PEX5 NBR1 RPS27A ATM EPAS1 UBA52 USP30 UBB RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 NFKB1 NFKBIA DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP62 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 CDK1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C CCT2 TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBB6 TUBB3 CCT7 TUBB1 TUBA3D TUBA3C CCT8 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PXN TESK1 PARVA PARVB ARHGEF6 RSU1 LIMS1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 HBEGF EGF ERBB2 EGFR NRAS NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi CHST8 B4GALT4 CGA FUT8 MAN2A1 MGAT5 MGAT2 FUCA1 MGAT3 MGAT4C CHST10 B4GALT6 B4GALT5 MAN2A2 ST3GAL4 MGAT4A LHB MGAT4B B4GALT1 ST8SIA6 FUT3 ST8SIA2 B4GALT2 B4GALT3 ST8SIA3 ST6GAL1 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism MTMR3 MTMR8 MTMR9 PIK3R4 RAB14 PIK3R2 MTMR6 PIK3R1 MTMR7 PITPNB INPP5E PIP5K1A PIP5K1B GDE1 SACM1L ARF3 MTMR14 VAC14 PI4KA PI4K2B MTMR10 MTMR2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A FIG4 PIP4P1 INPP4B INPP5J INPP5K PIKFYVE INPP5F PI4K2A PTEN MTMR1 PIP5K1C TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 GDPD1 RAB4A GDPD3 GDPD5 RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PNPLA7 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 PNPLA6 INPPL1 RUFY1 TPTE ENPP6 SBF1 PIK3CA PIK3R3 SBF2 TPTE2 PIK3C3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated APC MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle SLC25A11 MDH1 GOT1 MDH2 SLC25A12 SLC25A18 GOT2 SLC25A13 SLC25A22 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX9 MYD88 NFKB2 RELA NFKB1 IRF7 DHX36 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation RPS2 METTL21A KIN METTL22 HSPA8 EEF2KMT VCPKMT ETFBKMT EEF1AKMT2 EEF1AKMT1 EEF2 EEF1A1 CAMKMT VCP PRMT3 CALM1 ETFB TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 SLBP NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass PCNA UBA52 NPLOC4 POLH WDR48 USP10 RAD18 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL UBA7 RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2L6 TRIM25 UBE2B POLE2 POLE3 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KCNK12 KCNK15 FXYD4 FXYD3 FXYD2 DMPK FXYD1 FXYD7 FXYD6 MME ATP2B4 NPR1 RYR1 ATP2B3 NPR2 RYR2 ATP2B2 NPPC RYR3 ATP2B1 TRPC1 CORIN CES1 SLC8A3 CLIC2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 ATP1A4 CACNG6 ATP1A3 CACNG7 ATP1A2 TNNI3 ATP1A1 KCNIP1 KCNIP2 KCNIP4 KCNK6 RANGRF KCNK7 PLN KCNK1 KCNIP3 FKBP1B CACNA2D2 CACNB2 NKX2-5 SCN11A SCN10A CACNB1 SCN1B CAMK2B SCN1A CAMK2D CAMK2A KCNH2 TBX5 SCN3B SCN3A KCNK10 CACNG8 GATA4 CALM1 KCNK13 SCN2A CAMK2G KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 CACNG4 KCNJ2 KCNJ4 SCN9A KCNK9 SCN8A KCNJ12 CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A SCN4A KCNA5 SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 WWTR1 AHCYL1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors GPR31 FFAR4 FFAR1 FFAR3 FFAR2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PI4KB PIK3C2A PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2A ARF1 INPP5E TPTE SACM1L ARF3 OCRL TPTE2 PIK3C3 VAC14 PI4KA INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins KCNQ2 KCNQ3 SCN9A SCN11A SCN10A SCN8A SPTAN1 SPTA1 SCN5A SCN4A SCN4B SCN7A NRCAM SPTB ANK1 SCN1B SCN1A NFASC ANK2 ANK3 SPTBN4 SPTBN5 SCN3B SCN3A SPTBN2 SPTBN1 L1CAM SCN2A SCN2B CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 ERBIN HRAS SOS1 HSP90AA1 SHC1 ERBB2 CDC37 NRAS PTPN12 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN NCSTN APH1B PSEN2 PSEN1 YBX1 NOTCH3 APH1A ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage MAPDA GMPR2 ADK AMPD1 TK1 GMPR AMPD2 CDA AMPD3 DCK APRT DGUOK PNP HPRT1 ADA UCKL1 UCK2 UCK1 PUDP TK2 UPP2 UPP1 TYMP TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC26A2 SLC22A5 ABCB6 SLC24A2 ABCB4 SLC24A3 KCNJ11 SLC41A2 SEL1L SLC5A1 SLC41A1 SLC5A2 SLC30A10 ABCC9 ADCY9 SLC39A6 SLCO1B1 SLC39A5 SLCO1B3 ERLIN1 ADCY4 SLC39A8 ERLIN2 ADCY3 SLC39A7 CP ADCY2 SLC39A2 SLC6A5 ADCY1 SLC39A1 ADCY8 SLC39A3 SLC2A9 ADCY7 SLC26A4 SLC30A8 ADCY6 RNF185 SLC30A3 ADCY5 SLC26A3 SLC30A2 SLC31A1 SLC30A5 SLC40A1 SLC39A10 SLC2A1 ATP2A3 SLC30A1 SLC2A2 ATP2A2 SLC6A2 SLC39A14 ATP2A1 SLC6A3 SLC8B1 SLC8A1 SLC8A2 SLC22A12 HEPH ABCC2 SLC2A10 ABCC6 AVPR2 SLC24A4 SLC16A7 DERL3 SLC16A8 DERL1 EMB DERL2 SLC16A3 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 RHAG SLC24A5 APOB ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 GNAS RAB11A SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 NEDD4L ADD1 TUSC3 MAGT1 ZDHHC8 SLC46A1 SLC5A5 VDAC3 VDAC2 VDAC1 CFTR SLC32A1 SLC6A13 SLC6A1 ARF1 WWP1 CYB5R2 CYB5R4 CYB5RL SLCO1A2 NEDD8 ARL2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 VCP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SLCO4C1 HMOX2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 LETM1 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC6A7 ATP6V0B PLEKHA8 ATP6V0E1 ATP6V1G2 ATP6AP1 SLC6A11 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ABCG2 ATP6V0A2 SGK1 HBB ATP6V1H SLC6A4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 SLC17A7 ABCA3 ABCC3 CAMK2B ABCC1 CAMK2D ABCD3 CAMK2A SLC2A3 CALM1 CAMK2G ADD3 SLC4A7 PHB1 SLC25A10 CAND1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SEM1 SLC4A2 SLC4A3 SLC4A5 SLC5A8 SKP1 SLC5A9 TFR2 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A12 NIPA1 CUL1 NIPA2 CLTC SLCO4A1 SLC17A1 HDLBP RHBG PCSK9 CLTA DMTN SLCO2B1 AP2A1 SLC26A11 VLDLR LIPA SLC16A2 RHCG AP2A2 LIPC SLC26A1 CREB3L3 SLC15A1 IREB2 LIPG SLC14A1 CTNS LDLRAP1 SLC15A3 SLC14A2 AP2M1 SLC15A4 SLC4A10 CUBN CYBRD1 CYB5R1 PIP AMN SLC26A7 APOA2 ACO1 APOA1 SLC26A9 LSR SLC26A6 APOA4 PRKACG SLC25A1 APOA5 MB NPC1 RAF1 PRKACA SLC13A1 SOAT1 PRKACB SLC13A2 SOAT2 SLC13A3 NPC2 ANGPTL8 ATP7A SLC13A4 ANGPTL4 NGB SLCO1C1 LPA SLC47A2 CES3 TF CA1 SAR1B SLC47A1 SLC5A12 MTTP SLC5A10 LPL CA2 LMF2 SLC25A26 LMF1 LRRC8C CA4 LRRC8D APOF AP2S1 LRRC8A LRRC8B A2M LDLR SLC13A5 SLC11A1 GPIHBP1 LRRC8E GLTP FGF21 RSC1A1 MBTPS1 APOBR AHCYL2 APOC3 NIPAL4 NIPAL1 AP2B1 NIPAL2 TRPM1 NCEH1 ALB NIPAL3 TRPM2 P4HB AZGP1 TRPM7 SLC22A4 TRPM8 MBTPS2 SLC22A3 TRPM5 SLC22A6 TRPM6 SLC45A3 TRPM3 ANKH TRPM4 TRPC7 RAB11FIP2 ABCC4 TRPC5 SLC10A6 MCOLN3 MYO5B TRPC6 MRS2 AQP12A TRPA1 SLC22A15 AQP10 TRPC3 AQP8 SLC22A16 TRPC4 AQP9 SLC22A17 TRPC1 AQP6 SLC22A11 AQP7 SLC20A1 TRPV2 AQP4 SLC66A1 TRPV3 AQP5 FTMT TRPV1 MCOLN1 AQP2 ESYT3 MCOLN2 AQP3 ESYT2 AQP1 STEAP4 TRPC4AP MIP HFE TRPV6 MMGT1 TRPV4 AQP11 TRPV5 SLC2A6 SLC2A7 SLC2A8 PDZD11 GLRX3 CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 SLC35B3 LCN9 SLC35B2 STOML2 SLC27A1 MCUB LCN2 SLC35B4 SPG7 PHB2 SLC35D1 MAIP1 SLC35D2 LCN15 PARL AFG3L2 LCN12 SMDT1 SLC35A2 YME1L1 SLC35A3 PMPCB SLC33A1 SLC5A6 PMPCA ARL2BP MICU3 LCN1 MICU2 SLC29A4 MICU1 PRKAR1B SLC27A6 MCU PRKAR2B SLC28A2 PRKAR1A SLC29A1 PRKAR2A SLC2A13 SLC28A1 SLC29A3 SLC5A11 SLC5A3 SLC29A2 SLC28A3 SLC27A4 CYGB EIF2S2 EIF2S1 EIF2S3 PSMD8 PSMD6 HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 TFRC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 ABCA6 ABCD2 UBA52 AKAP1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 SLC6A9 PSMB7 SLC17A6 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 UBC ABCC5 PEX3 ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 SLC1A5 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 PEX19 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 FURIN BEST3 PCSK6 SLC9C2 BEST1 PCSK5 BEST4 ESYT1 SLN ATP11C SLC67A1 ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 STEAP3 ATP8B1 ATP4B ATP4A FXYD4 FXYD3 WNK1 FXYD2 WNK2 FXYD1 HBA2 WNK3 FXYD7 FXYD6 CUTC RYR1 RYR2 RYR3 UNC80 ATP7B CLIC2 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 SLC22A7 STOM SLC12A2 SLC12A4 RUNX1 SLC12A5 SLC12A7 FTH1 FTL SLC25A18 CETP SLC25A11 APOD APOE ABCA1 ABCG8 MYLIP SLC25A22 ABCG5 NR1H2 APOC4 NR1H3 APOC2 APOC1 ANGPTL3 ABCG1 SLC35C1 SLC24A1 SLC17A5 AVP SLC2A4 SLC35A1 SLC22A8 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling CREBBP RELA ICAM2 LYN ICAM3 RELB NFKB1 EP300 NRAS PAK1 PAK3 HRAS FYN PRKACG RAF1 PRKACA PRKACB PAK2 CD209 RPS6KA5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B RAD50 RAD51D BLM RAD51 MRE11 RAD51C BRCA1 BRCA2 RAD51AP1 WRN ATM BRIP1 DNA2 KAT5 EXO1 RBBP8 NBN MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DBT DLD VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 PCNA CDC6 HDAC1 DYRK1A CDK1 CDC25A E2F1 RBBP4 CDK2 TFDP1 CCNE2 TFDP2 LIN54 TOP2A LIN37 CCNE1 LIN9 MAX LIN52 MYC E2F4 E2F5 CCNA2 CCNA1 MYBL2 RBL2 RBL1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO6 FOXO3 FOXO1 RPS6KB2 AKT1 AKT2 FOXO4 NR4A1 AKT3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis RXRA SCD NR1H2 FASN NR1H3 RXRB NRIP1 ANGPTL3 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 HSP90B1 DDIT3 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25A PKMYT1 WEE1 CLSPN YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 CDC25C ABRAXAS1 TP53BP1 H2AX H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDC7 CDK2 CDC45 MDC1 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SFN YWHAZ PSMA5 PIAS4 PSMA6 PSMA3 PSMA4 BRCC3 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 BLM MRE11 PSMA7 BRCA1 BABAM1 PSMB6 BABAM2 PSMB7 WRN BRIP1 KAT5 PSMB4 EXO1 UIMC1 CHEK1 PSMB5 RBBP8 NBN UBB TOPBP1 PSMB2 ATRIP PSMB3 BARD1 UBC RFC5 RMI2 PSMB1 RFC3 GTSE1 RFC4 RPS27A RMI1 RFC2 TOP3A ADRM1 RPA1 HUS1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 RAD50 PSMC4 PSMC1 MCM7 PSMC2 MCM8 RPA3 RAD17 TP53 CCNB2 CCNA2 RAD1 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 ORC5 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription REST SRF NR3C1 KCNIP3 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling MET GAB1 PIK3R1 HGF PIK3CA G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint WEE1 CCNA2 CCNB2 CCNA1 CCNB1 CDK1 PKMYT1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells RELA MAP3K7 NFKB1 CHUK IKBKB CARD11 MALT1 NFKBIA PSMD8 PSMD6 PSMD7 PSMD2 REL NFKBIE PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PSMC5 PSMC6 PRKCB SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 RAB11FIP3 RAB8A ARF4 GBF1 PKD2 RAB3IP PKD1 RAB11A RHO CNGA2 CNGA4 EXOC8 EXOC7 CNGB1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG MTR MTRR INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 FZD2 APC FZD5 PPP2R5B WNT1 PPP2R5A FZD1 PPP2R5D PPP2R5C CSNK1G2 WNT3A LRP5 CTNNB1 LRP6 WNT8A WNT8B PPP2R1B PPP2R1A PPP2CA PPP2CB DVL1 DVL2 DVL3 AMER1 GSK3B CSNK1A1 CAV1 FRAT1 PPP2R5E AXIN1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT DHRS7B AGPS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins MUC13 B3GNT3 B3GNT5 B4GALT6 B4GALT5 GALNT12 ST6GALNAC2 C1GALT1C1 MUC12 ST6GAL1 MUC15 MUCL1 MUC3A MUC5AC MUC3B GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ST6GALNAC3 GALNT10 GALNT9 ST6GALNAC4 MUC1 GALNT8 MUC2 B3GNT9 QTGAL B3GNT8 B3GNT6 MUC7 GALNT1 CHST4 MUC4 GCNT1 MUC6 GCNT3 MUC16 GCNT4 GALNT3 GCNT7 MUC17 GALNT7 C1GALT1 GALNT6 MUC19 GALNT5 ST3GAL4 GALNT4 MUC5B A4GNT MUC20 GALNTL5 MUC21 GALNT2 GALNTL6 ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT4 B3GNT2 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL WDR83 SRC YWHAB HRAS IL17RD ARRB1 ARRB2 LAMTOR2 MAP2K1 MAP2K2 ITGB3 LAMTOR3 ITGA2B RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell DISP2 SCUBE2 SHH IHH DHH ADAM17 NOTUM GPC5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance KIFAP3 APOOL PRKACA KIF3B KIF3C ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 YWHAE CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 YWHAG RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 RAB11A ATAT1 TTC8 SOD2 CARM1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 MED1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 ACSS2 NR1D1 CHCHD3 PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 MEF2C PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 CCP110 MAPK12 TNPO1 HCFC1 PPARGC1A PPARGC1B CEP57 CETN2 CEP164 ACTR1A PCM1 NRF1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HSPA9 HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 ALAS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 HAUS7 CEP70 CEP72 CEP192 PCNT TUBA4A CEP76 CEP78 PLK4 ATP5F1A SIRT3 ATP5F1B ODF2 CEP152 NEDD1 ALMS1 MTX2 PPARA CEP41 CYCS CEP43 IFT172 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 CCT3 RPGRIP1L DMAC2L WDR35 IFT88 SMO TCP1 ESRRA KIF3A TTC21B WDR19 IFT122 MKS1 MT-ATP6 CCT8 CCT5 CCT4 CEP97 TUBB4B KIF17 TUBB4A ATP5PF ATP5PD ATP5PB ATP5F1C HSP90AA1 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 ATP5PO HDAC6 RHO CNGB1 PPP2R1A CPAP ATP5MC2 ATP5MC3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 TFAM TFB2M RXRA DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 SAMM50 PDE6D HDAC3 MTX1 MAPRE1 PAFAH1B1 TBL1X DYNC1I2 NCOA1 NCOR1 CLASP1 TBL1XR1 DYNC1H1 NDE1 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 CALM1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 NCOA2 NCOA6 CDK1 GLUD1 GLUD2 SIRT4 CRTC2 CRTC3 CRTC1 HELZ2 CREBBP CHD9 MICOS13 MICOS10 CHCHD6 MTERF1 RAB8A GABPA SIRT5 TGS1 PPRC1 MEF2D PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 TFB1M RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MRM3 RCC1L RPUSD4 NGRN DDX21 RPUSD3 NOP58 RPS4Y2 RPS27L RPS4Y1 TRMT10C PRORP RPS4X RPS15 ELAC2 RPS14 RPS17 HSD17B10 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction SOX17 POU5F1 FKBP6 SPAM1 LMNB1 CXCR4 PRDM1 PDPN FIGNL1 TEX12 TEX15 MSH4 MSH5 CD9 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B HVCN1 MND1 FIRRM REC8 SYCP3 STAG3 DMC1 PSMC3IP MLH3 CDK4 PRDM9 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L SPO11 H2BC21 SUN2 SUN1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 EOMES H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 NANOS3 CBFA2T2 H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 BMP4 H2BC1 POT1 TERF2IP H2AC20 NANOG HSPA2 CDK2 MLH1 B4GALT1 TFAP2C UBE2I CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 ZP3 ZP2 TET2 ZP4 BLM MRE11 BRCA1 BRCA2 RBBP8 NBN TOP3A RPA1 RPA2 RAD50 RAD51 RAD51C RPA3 ATM ATR DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN3 PAIP1 LSM5 LSM4 SKIC2 LSM3 LSM2 LSM7 LSM6 DDX6 LSM1 PATL1 CNOT4 EDC3 EDC4 CNOT6 DCP1B CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT11 DIS3 XRN1 SKIC8 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 CNOT6L EIF4A2 EIF4A1 DCP1A TUT7 TUT4 EIF4G1 HBS1L NT5C3B SKIC3 EIF4A3 DCPS PAN2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes IKBKB SQSTM1 UBC MYD88 RPS27A IRAK1 NGF TRAF6 UBA52 NGFR PRKCI UBB RIPK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription RBPJ MAML2 FCER2 MAML1 MAMLD1 HES1 MAML3 EP300 GZMB NOTCH2 HES5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPKAPK2 MAPK1 MAPK8 ATF1 MAPK3 ATF2 PPP2R1B PPP2R1A PPP2CA PPP2CB MEF2C MAPK9 MAPK14 MAPK11 MAPK10 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK HDAC1 H2AC20 ERCC6 MBD3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MTA2 RBBP4 MTA1 MYBBP1A MTA3 TTF1 RBBP7 ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP85 NUP62 NUP43 RCC1 RAN NDC1 SEC13 RANGAP1 UBE2I NUP155 NUP133 SUMO1 NUP93 NUP35 NUP54 NUP205 NUP37 POM121 NUP107 NUP188 KPNB1 TNPO1 NUP160 AHCTF1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere ACD LIG1 PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 BLM RPA3 WRN DNA2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 AKR1D1 CYP46A1 CYP27A1 CYP39A1 HSD3B7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 ANAPC4 NEK2 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 UBB UBC BUB3 RPS27A MAD2L1 ANAPC15 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation HPGDS GSTA3 GSTA1 GSTM4 AKR1A1 GSTT2 GSTT1 ESD GSTT2B GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 GSTZ1 GSTA5 GSTA4 GSTO1 CHAC1 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GSTA2 GGT3P GGT1 GCLM MGST3 MGST1 GSTP1 MGST2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance CLTC PCSK9 AP2S1 CLTA AP2A1 LDLR LIPA AP2A2 AP2B1 NCEH1 LDLRAP1 AP2M1 LSR APOB NPC1 SOAT1 SOAT2 NPC2 CES3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes ITGA5 PIEZO1 CACNA2D1 SPP1 CACNG7 GJA1 CACNA1H PANX1 HSPG2 CACNB2 AKT1 ITGB3 P2RX7 ITGB1 CACNB1 CACNB3 ITGAV SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants MAPK1 DUSP9 DUSP6 DUSP16 DUSP7 DUSP10 DUSP8 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis COQ9 COQ7 COQ6 COQ5 COQ2 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A STARD7 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN LAT2 SYK FYN BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs HPGD PTGS2 ALOX15 ALOX5 LTA4H PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis ADSS2 GART PAICS PFAS IMPDH1 ADSL IMPDH2 PPAT ATIC GMPS ADSS1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins JUN RELA IRAK1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A IL1B PELI1 MMP1 MMP2 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 MAPK8 SOCS1 IKBKB SQSTM1 MYD88 FCER2 CANX PTGS2 ALOX5 RBX1 SDC1 HIF1A SNAP25 GATA3 LYN INPP5D ARF1 RALA RPLP0 IL1RN PITPNA BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CSF1R MAP3K7 FPR1 MAP2K6 TCP1 BCL6 SMAD3 NFKBIA TAB1 TRAF2 TEC TRAF6 USP14 NOD1 ITGAM ITGB2 NOD2 IRS1 USP18 PPP2R1B IRS2 PPP2R1A PIK3CB FGF2 TNFRSF1B SOX2 TNIP2 PTPN13 INPPL1 TWIST1 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 SHC1 PPP2R5D PIK3R2 PIK3R1 RHOU ALOX15 MAPK1 BIRC5 CHUK MAPK3 PTPN11 CDC42 LIFR PPP2CA PPP2CB HNRNPF CASP1 OPRM1 IFNG MCL1 CD86 PTK2B CD80 VEGFA IL22 POMC CXCL1 NFKB2 JAK2 HNRNPA2B1 IL2RG MMP9 FBXW11 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B CCL3L3 CCR5 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 P4HB PRTN3 TIMP1 POU2F1 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FN1 BRWD1 BLNK BTRC S1PR1 JAK3 CD4 LCN2 STAT2 MMP3 IL23R IL13RA2 IL13RA1 IL4R IL23A CDKN1A FSCN1 NDN LIF NANOG IGHE OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 IL11 PIM1 IL19 IL16 IL17RE OSMR PSMD8 IL17RB PSMD6 HMOX1 IL31 IL17C PSMD7 IL11RA SOCS2 IL7 PSMD2 IL7R IFNL2 PSMD3 IFNL1 AKT1 IFNL3 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A UBE2V1 HSPA8 VAMP2 ICAM1 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 RAG2 RAG1 IL32 CASP3 IL34 IL1RL1 IL33 TGFB1 LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 RORC RORA TNFRSF1A HSP90AA1 CBL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 MAP2K1 HSP90B1 H3C15 STAT3 NFKB1 ITGAX FASLG IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs JOSD2 UBC RAD23A JOSD1 ATXN3L RPS27A VCP RAD23B PRKN UBA52 ATXN3 UBB SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT CLTC CLTB FZD7 WNT5B WNT5A ROR1 CLTA ROR2 AP2A1 PRICKLE1 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 PRKG2 AP2S1 ITPR1 ITPR2 AP2B1 ITPR3 WNT10A DPY30 WNT7B WNT7A BTRC PRKCB RAC1 WNT6 PPP3CA WNT2 PPP3CB GNAT2 PRKG1 PLCB3 WNT2B PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 WNT16 NFATC1 GNAO1 TCF7L2 TCF7L1 HDAC1 LEF1 PIP5K1B TCF7 CTNNB1 ASH2L TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 RSPO3 TNRC6A TNRC6B TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 VPS29 PSMD1 VPS35 WLS VPS26A TMED5 PRKCA TLE5 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SNX3 PSMA2 CSNK1G2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 SFRP1 PSMB5 CSNK1E SFRP2 WIF1 UBB PSMB2 SOST PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 MEN1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PRKCG GNG10 CHD8 GNG12 CAV1 CBY1 SOX3 GNG11 SOX17 GNG13 XIAP RNF146 SRY SOX6 GNB2 SOX7 SOX4 GNB1 BCL9L RUVBL1 CTNNBIP1 SOX13 MAP3K7 GNB4 USP8 PYGO1 GNB3 BCL9 PYGO2 GNB5 GNGT1 TLE4 TLE2 TLE1 GNGT2 CUL3 TNKS GNG3 SMURF2 GNG2 GNG5 GNG4 GNG7 GNG8 USP34 ARRB2 SCRIB VANGL2 WDR5 AXIN2 RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 LGR6 KLHL12 LGR5 WNT3 CCDC88C RSPO4 LGR4 DACT1 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B DAAM1 H2BC21 PFN1 EP300 PARD6A SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 H3C15 PPP2R5E FRAT2 H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 H2BC1 H2AC20 RHOA PPP2CA PPP2CB SMURF1 CAMK2A AMER1 CALM1 GSK3B CSNK1A1 AXIN1 APC PORCN CDC73 LEO1 KAT5 CTBP2 CTBP1 CREBBP TERT WNT10B WNT9B SEM1 SMARCA4 WNT4 TLE3 SKP1 CUL1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4 AGRN B3GALT6 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MBD3 GATAD2B GATAD2A CHD3 DPF1 HDAC2 DPF2 DPF3 CHD4 SS18L1 ARID1A ARID1B SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 SMARCC1 MTA1 SMARCC2 MTA3 RBBP7 ACTB SPOCD1 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 PIWIL4 H3-3B H3C8 H2AC8 DNMT3L H2AC6 BCL7A H2AC7 BCL7C H2BC17 BCL7B SMARCA2 H2BC12 SMARCA4 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 C19orf84 H3C15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 MBTPS1 HSP90B1 MBTPS2 DDIT3 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control VCP RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 TCF25 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 ZNF598 RPS27 RPS23 ANKZF1 ASCC2 KLHDC10 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling CRLF1 TYK2 CANX IL6ST JAK2 IL27RA EBI3 STAT3 JAK1 STAT1 IL27 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o DPM3 DPM1 DPM2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport SLC22A5 RSC1A1 SLC14A1 SLC14A2 SLC22A4 SLC67A1 SLC22A2 SLC22A3 SLC22A1 RUNX1 SLC22A15 SLC22A16 SLC47A2 SLC47A1 SLC25A26 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RELA NFKB1 BST2 NPM1 ITCH PCBP2 NLRP3 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 UBE2I MAVS TKFC YWHAB FKBP1A RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 YWHAQ PYCARD YWHAG YWHAH YWHAZ SFN PPIB TRAF3 TRAF6 UBA52 TLR7 IFIH1 RIPK3 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 TOMM70 UBB RPS17 RPS15A RPS16 RPS19 UBC SP1 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 BCL2L1 EP300 RPS13 RPS12 RPS9 RPS7 RPS8 PPIA IRAK2 RPS5 RPS6 PSMC6 RPSA RPS3A RUNX1 RPS26 EEF1A1 RPS25 RPS28 KPNA2 PDPK1 RPS29 RPS20 FAU RPS21 RPS24 PPIH RPS27 RPS23 PPIG CAV1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSME1 PSMB10 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMD9 PSMD4 PSMA5 PSMD5 PSMA6 PAAF1 PSMA3 PSMA4 PSME3 PSMA1 PSME4 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMD12 PSMG4 PSMD11 PSMG1 PSMG2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBC RPS27A CBL UBA52 MKNK1 SPRY2 MAPK1 MAPK3 BRAF PTPN11 UBB PPP2R1A BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors STAB2 APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 HSPH1 HYOU1 IGLV2-11 SCARF1 S100A9 IGLV1-40 APOB HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 HMGB1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 COL4A2 COL4A1 FTH1 PRDX1 SCGB3A2 MASP1 SPARC FTL V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 APOE V2-8 V1-20 CALR V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD36 LRP1 COL1A1 SSC5D COL1A2 STAB1 CD5L SAA1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CCL2 EDNRA CCL1 EDNRB CCL19 PROK2 CCR2 CCL17 AVPR2 PROK1 AVPR1A CCL16 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP NMS PDYN NMU AGTR2 FPR3 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 CCKAR PNOC SSTR3 EDN1 GPR37 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR MT-RNR2 INSL3 F2RL1 INSL5 PENK F2RL2 F2RL3 APLN GPR37L1 KEL PMCH NLN PPY MC1R GHSR MC4R F2R MC3R UTS2 GAL NTS MCHR2 NPB NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R NPY1R APLNR BDKRB2 BDKRB1 QRFPR XCL2 XCL1 PYY HEBP1 CCK GPER1 HCRTR2 HCRTR1 NPY5R KISS1 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 OPRD1 ACKR1 C5AR2 C5AR1 C5 AGT PF4 C3 FPR1 NPY CXCR1 CXCR2 OPRM1 SST OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling IL18RAP IL18R1 IL4 IL18BP IL13 IL18 IL37 ALOX5 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants HRAS NRAS KRAS ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins YWHAH SFN YWHAZ DYNLL1 DYNLL2 PPP3CC E2F1 BID TP63 PPP1R13B MAPK8 BCL2L11 TFDP1 TFDP2 BAD BBC3 BCL2 PMAIP1 AKT2 BMF YWHAB YWHAE TP73 TP53 AKT1 PPP3R1 TP53BP2 YWHAQ YWHAG AKT3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions PARD6G CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 PRKCI CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 PATJ CLDN18 CLDN17 CLDN16 PARD6A F11R CRB3 PARD6B PARD3 CLDN5 PALS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C S100A9 S100A8 YWHAE YWHAQ YWHAG YWHAH FLNA LIMK2 PRKCB RAC1 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 CTNNB1 CDH1 YWHAB MYL9 XPO1 CYFIP1 NCKAP1 PRKCD AR PRKCA NCF1 SFN YWHAZ NCF2 NCF4 CFTR BRK1 BTK CFL1 CYBB CYBA ACTB NOXO1 MEN1 MAPK14 MAPK11 PAK1 MYLK NCKAP1L WASF1 PAK2 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX3 ABL1 NOX1 ROCK1 ROCK2 WIPF1 WIPF2 CYFIP2 WIPF3 NUP107 LIN7B NUP160 CIT IQGAP1 NUP85 PKN3 IQGAP2 IQGAP3 NUP43 RANBP2 SEC13 GOPC CDC25C PKN2 NUP133 PKN1 CDKN1B NUP37 ERCC6L WASL ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 MRTFA KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 DAAM1 H2BC21 ZW10 NCK1 PFN1 WAS MAD1L1 PFN2 H3-3B CDCA8 H3C8 PRKCZ H2AC8 PMF1 SKA1 H2AC6 SKA2 PAK3 H2AC7 DSN1 H2BC17 WASF3 DVL1 DVL2 H2BC12 DVL3 H2BC13 SRGAP2 H2BC14 SCAI H2AJ RCC2 KTN1 PDPK1 H2BC15 NDC80 ZWINT H2BC11 DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PIK3C3 H3C15 PPP2R5E NUF2 KIF14 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 H2BC1 RHOC RANGAP1 RHOD H2AC20 CKAP5 DYNLL2 RHOQ RHOA RHOB KIF2A KDM1A MAPK1 INCENP PIN1 BIRC5 EVL KIF2C RTKN KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 MAPK3 CENPA AURKB NSL1 CENPC CDC42 PPP2CA RHPN1 PPP2CB RHPN2 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ DLG4 SPC24 CALM1 SPC25 MAD2L1 CENPS PLK1 NCOA2 CTNNA1 PPP1CB PPP1R12A PTK2 CLIP1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation MAPK1 SOS1 SHC1 INS MAPK3 GRB10 IRS1 INSR IRS2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) RPS6KA1 JUN H2BC9 H2AZ2 CXCL8 H4C9 VENTX H2BC8 RELA H2BC5 H2BC3 MAPK7 STAT3 H2BC1 CDKN1A NFKB1 CDKN2A H2AC20 MAPK1 CDK2 CEBPB MAPK3 EHMT2 EHMT1 IL6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDKN2D ANAPC11 CDKN2C CDC23 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 CDKN1B ANAPC4 ANAPC5 FZR1 ANAPC1 ANAPC2 IGFBP7 CDK6 IL1A CDK4 H2AX UBB H2AB1 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS CCNA2 CCNA1 H2BC11 RPS6KA3 RPS6KA2 H3C15 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription HOXC8 HEYL FOXF1 SP1 ILF3 ZEB2 SNAI1 PRDM8 BHLHE22 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses CGAS TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC TRIM21 STAT6 MRE11 NLRC3 IFI16 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling ADAR ARIH1 PPP2R5A STAT3 NPM1 HSPA1L DHX9 HSPA2 CHUK SPHK1 EIF2AK2 ISG15 MAP2K6 STAT1 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB FANCC PPP2CA PPP2CB PRKRA TARBP2 UBE2I MAVS SNCA SUMO1 DUS2 TRIM25 CENPS CENPX ILF2 CDK1 ILF3 IKBKG PPP2R1B PPP2R1A PTPN2 DNAJC3 NCK1 FAAP100 FAAP24 HSPA8 FAAP20 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A TP53 UBE2L6 HERC5 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF10 FGF2 EGF FGF4 FGF7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LMF1 GPIHBP1 FGF21 MBTPS1 FURIN PCSK6 LIPC CREB3L3 APOC2 PCSK5 ANGPTL3 MBTPS2 APOA4 APOA5 ANGPTL8 ANGPTL4 LPL LMF2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response XIAP CARD8 CYCS UACA BAK1 CDKN2A GSDMD GSDME BAX MAPK1 C1QBP AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance PCNA RUVBL1 NPM1 WRAP53 PIF1 GAR1 CTC1 CENPW CENPX RUVBL2 OIP5 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 RBBP4 RTEL1 CHTF8 DAXX ATRX RSF1 RBBP7 PRIM2 MIS18A PRIM1 POLA1 H2AX DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 KNL1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC1 H3-3B STN1 TEN1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 CDK2 ITGB3BP CENPA CENPC FEN1 CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L BLM WRN HJURP RFC5 RFC3 RFC4 TERT RFC2 RPA1 MIS18BP1 RPA2 RPA3 CCNA2 CCNA1 DNA2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors PIAS4 PIAS3 TFAP2B SUMO3 SUMO2 TFAP2C UBE2I PIAS1 CDKN2A SUMO1 MDM2 FOXL2 MITF HIC1 SP3 MTA1 TP53BP1 TP53 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3 CRIPTO DPPA4 ZIC3 EPHA1 FGF2 SALL4 STAT3 SOX2 POU5F1 NANOG SALL1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B2 SRD5A3 HSD3B1 CGA LHB HSD17B3 HSD17B12 SRD5A2 CYP17A1 SRD5A1 POMC SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 RXRA APH1A TGFB1 GIPC1 TGFBR1 PSENEN TGFBR2 NCSTN APH1B PSEN2 PSEN1 ACVR2A INHBA INHA TGFB2 SP1 TIMP2 FGF2 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B TIMP1 MYF5 TCF3 HELLS TCF12 KLF16 ARRB1 ARRB2 RARA MMP14 MMP16 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression TP53 PRDM1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 GP9 ADAMTS13 VWF GP1BA GP1BB AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation NTRK1 PIK3CB PIK3R2 PIK3R1 NGF PIK3CA IRS1 RHOA IRS2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 H2BC1 LIG4 MDC1 PAXIP1 RNF168 NSD2 PIAS4 BRCC3 PRKDC MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN BARD1 H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2BC15 DCLRE1C RIF1 H2BC11 ATM POLL NHEJ1 POLM TDP2 TDP1 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy CETN1 PARK7 UBC DYNC1LI1 CFTR RPS27A DYNC1I1 HSP90AA1 DYNC1LI2 DYNLL1 UBE2V1 PRKN DYNC1H1 UBA52 ARL13B DYNLL2 HDAC6 PCNT HSF1 VCP IFT88 DYNC1I2 UBE2N UBB RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter CRCP TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 POLR1C POLR1D INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease RELA ARPC1B NPM1 ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 NR3C1 IRAK1 NCKIPSD IL6 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 VAV3 MED4 MED6 MED7 UBE2N VAV1 VAV2 MAPKAP1 NEDD4L C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 V1-11 PTGES3 V1-16 V1-13 MAPK8 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB V2-8 V1-20 V1-9 TAF7L V5-4 FEN1 V1-7 V5-1 V1-5 UBE2I V1-3 V5-6 SUMO1 C1QA C1S UBE2D2 ELOB V4-6 ELOC V4-2 RBX1 V4-1 VHL RNMT CCNH POLR2A ISCU SNAP25 POLR2B POLR2C POLR2D SYT1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 GNG10 GNG12 GNG11 GNG13 KPNA7 KPNA4 GNB2 KPNA5 GNB1 GBP1 KPNA3 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 CDK8 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 ACTG1 PPP1CC TXNRD1 PML DYNC1LI1 DYNC1LI2 FCGR2A DVL1 DVL2 DVL3 TXN RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 HBB CD33 CHUK TJP1 DYNC1I2 CDC42 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X NFKB2 JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 PRKACG IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 FCGR3A BRD4 RPS18 CRBN RPS3 MYH2 MYO10 IGLC7 RPS2 IGHV3-53 MYO1C RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 PRKAR1B RPS5 PRKAR2B RPS6 PRKAR1A RPSA PRKAR2A RPS3A PRKX RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HBEGF HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E RNF213 ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A GBP2 GBP4 TLR6 IKBKE IRF7 CYFIP1 NCKAP1 BRK1 RAN NEK2 PDIA3 TUBB CYBA VPS36 VPS25 CBX1 SNF8 CHMP1A RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L SUGT1 WASF1 PAK2 IGF1R WASF2 CALM3 CALM2 CAV1 BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A WIPF1 WIPF2 FXYD4 WIPF3 FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 FCGR1A SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C DUSP16 TMPRSS2 WASL SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 NRP1 MAP2K1 MAP2K2 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 ENO1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 PGK1 ARID4B SAP30 MAP2K4 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD MAP2K7 TAB3 TAB2 NFKBIB ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 ARIH1 IFNA13 IFNA14 ADCY9 IFNA16 SAP30L IFNA17 ADCY4 BAG2 MED9 ADCY3 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 FGR GGT5 PATJ VPS39 VPS18 LARP1 ITPR1 VPS11 ITPR2 GGT1 VPS16 ITPR3 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 NOS2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 P2RX7 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 P2RX4 PARP8 TUFM GEMIN4 GEMIN5 CRK GEMIN6 GEMIN7 GNAS GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 GSDMD DNAJC10 NMT1 VPS33B RIPK3 CORO1A IL18 HGS IL1A RAB5A KPNB1 IL1B TLR4 BCAP31 FNTA CHMP4C UPK1A EPCAM CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 STAM RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IL10 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 AHCYL1 TAF9B KPNA2 MAP3K7 H2AC1 STAM2 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 GNAZ CD163 SMAD4 RHBDF2 ADORA2B SMAD3 ADAM17 NFKBIA SCAP MAVS CYFIP2 TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 WASF3 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 DPEP2 CRNKL1 CDC40 DPEP1 ATP6V1H MAPK1 DHX9 CSTF3 CSTF2 ELMO2 MAPK3 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D SRC RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 CALM1 DOCK2 CAMK2G HNRNPH2 DOCK1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CTSG CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 LTF TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 CD9 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 MET ACOT2 STX1A CDH1 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 C3 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B TRIM27 HSP90AA1 CBL EGFR PLCG1 RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 SFPQ IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 GNAI3 GNAI1 GNAI2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 SH3GL3 EPS15 SH3GL2 SH3GL1 ST3GAL1 ST3GAL2 ST3GAL3 YES1 EEF2 CTSL SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses RELA PPIB NFKB1 BST2 TRAF3 TRAF6 UBA52 ITCH TLR7 IFIH1 RIPK3 KPNB1 PCBP2 UBB TOMM70 NLRP3 UBC RPS27A TBK1 IRF3 NFKBIA STING1 MAVS IRAK2 PPIA TKFC FKBP1A RUNX1 RIGI RCAN3 KPNA2 NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 PPIH PPIG PYCARD PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A APOL1 COPS3 COPS6 HMGB1 COPS5 COPS8 PRDX1 CHMP3 CHMP6 CHMP7 PLA2G6 V2-11 V3-4 DCTN6 V3-3 DCTN5 V2-17 DCTN1 GJC1 V3-2 DCTN4 GJC2 V2-15 GJA3 V2-19 V1-11 GJA10 GJA5 CLTCL1 GJA4 V1-16 MAN2A1 GJA9 V1-13 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 V2-8 GJB5 V1-20 GJB7 CHM TMED2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 CD59 DNM3 CD55 V4-6 V4-2 V4-1 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 CD163 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 HP STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 HBB TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 APOA1 COG8 COG7 COG6 COG5 COG4 IGHV3-23 COG3 RAB27B COG2 COG1 IGLV RINT1 RAB30 IGLV2-8 RAB36 IGKV1-16 TF KIF16B IGKV1-17 SAR1B KDELR2 IGKV1-12 KIF20B IGHV3-7 COPB2 IGHV3-9 COPA IGHV3-30 TMED10 ARL1 IGHV3-33 AP2S1 KIF3B AGTR1 IGKV1D-39 MAN2A2 VTI1A LDLR IGKV1D-33 SERPINA1 KIF3C RAB6B IGKV2D-28 RAB39A IGKV4-1 KIF18B IGHV7-81 KIF4B AP2B1 ALPP IGKV2D-30 KIF4A IGHV4-59 ALB COPE IGHV1-69 KIF12 KIF11 USE1 IGLV2-11 BICD1 S100A9 RABEPK IGLV1-40 BICD2 IGLV1-47 KIF15 KIF19 IGLV6-57 IGLV2-14 MAN1A2 F5 IGLV1-44 KIF13B F8 TMED3 KIF1C IGKV3-15 KIF1B IGKV3-11 IGKV2D-40 MAN1A1 IGHV3-11 KIF1A IGHV3-13 TMED7 TMED9 IGLV7-43 IGKV1D-16 NAA30 IGKV1D-12 KIF25 COPZ2 IGLV1-51 IGLV2-23 KIF22 STX4 KIF6 BET1L IGKV3-20 KIF27 COPZ1 SH3KBP1 SLC2A8 IGHV4-34 RAB33B IGHV1-2 KIF9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 CD3G IGHV NAA35 CD3D IGKV2-29 NAA38 VAMP4 IGKV2-28 PAFAH1B3 IGLC3 ARF5 NAPA NAPB IGLC1 NBAS CHRM2 IGLC2 TMF1 STX16 IGKV3D-20 STX18 GOSR1 GOLGA2 NAPG STX10 IGKV2-30 IGLV3-19 CYTH3 ARFRP1 IGHV2-70 IGHV2-5 CYTH2 IGLV3-1 CYTH4 IGHV3-48 CUX1 IGLV3-25 VPS51 CD4 IGLV3-27 VPS53 VPS52 IGKC IGKV1-39 MAN1C1 IGLV3-21 BNIP1 STX6 IGKV1-33 VPS54 CYTH1 RIC1 IGLC7 IGHV3-53 MYO1C GALNT2 ARCN1 IGKV5-2 RGP1 KIF26A IGLC6 IGKV1-5 KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB CALR PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A COL1A1 COL1A2 SSC5D STAB1 CD5L SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 STAB2 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 HSPH1 SNX2 FNBP1L HYOU1 SNX9 SNX5 SCARF1 TBC1D8B PUM1 HBA2 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 HSP90AA1 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 COLEC12 KIF20A MSR1 TMEM115 CNIH2 COLEC11 CNIH3 SCARA5 HSP90B1 MCFD2 MARCO MIA2 COL3A1 PPP6R1 COL4A2 COL4A1 TRAPPC6A FTH1 TRAPPC6B SCGB3A2 SEC22A SEC22C MASP1 FTL SPARC STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF APOE PLIN3 GGA2 GGA1 GGA3 CD36 LRP1 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 SAA1 TGFA HPR HPX IGHA1 IGHA2 EREG AMBP BTC JCHAIN EPGN AKT3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDC7 CDK2 CDC45 PRIM2 PRIM1 POLA1 POLA2 POLE MCM10 RPA1 DBF4 RPA2 RPA4 MCM7 MCM8 POLE4 GMNN RPA3 MCM3 MCM4 POLE2 MCM5 POLE3 MCM6 MCM2 ORC5 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle TRAK1 TRAK2 RHOT1 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SLBP LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants LRP5 KREMEN1 KREMEN2 DKK1 DKK2 DKK4 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade SERPING1 CFD C3 GZMM CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 CD81 C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S FCN1 C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC FCN2 FCN3 CRP COLEC10 PROS1 F2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription SGK1 NAB1 NAB2 LYL1 REST F3 ATF1 DNM2 SRF ARC TRIB1 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 SH3GL3 ID1 CDK5 VGF ID4 FOSB EP300 ID3 JUNB CDK5R2 MEF2D TCF12 FOS CHD4 ELK1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding OGG1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency NAGS TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway CREBBP TBK1 IRF3 TRAF3 EP300 MAVS RNF135 RIGI IFNB1 IFIH1 TRIM25 IKBKE TRIM4 IRF7 SIKE1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCD4 TCN2 CD320 LRP2 ABCC1 LDLRAP1 TCN1 LMBRD1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres ACD TINF2 PCNA TERF1 TERF2 RUVBL1 POT1 TERF2IP WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 BLM RTEL1 CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 RFC5 POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 CHTF18 RFC2 TERT RFC1 STN1 RPA1 TEN1 RPA2 RPA3 CCNA2 CCNA1 DNA2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GUSB SGSH GNS ARSB GALNS HGSNAT NAGLU HYAL1 GLB1 IDS IDUA DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm YAP1 SMAD2 SMAD3 TBXT LEF1 TCF7 TEAD2 NOTO TEAD4 FOXH1 FOXA1 CTNNB1 SHH FOXA2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D TBCE TUBA3C TUBA8 TUBA1C TUBA4B TUBA1B TUBA4A TUBA1A TUBB4B TUBB4A TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SLC24A2 SLC24A3 SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SRI CALM1 SLC24A5 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling XIAP RELA MAP3K7 NGF USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 NSMAF SMPD3 SMPD2 RIPK1 TBK1 IRAK1 ADAM17 NFKBIA TAB1 TAX1BP1 ARHGDIA YWHAE TNFAIP3 RNF31 SPATA2 TNFRSF1A OTUD1 UBE2L3 TRAF2 TNFSF10 TRAF6 PRDM4 FADD BIRC2 BEX3 BIRC3 CFLAR PRKCI USP21 TRIO RASGRF2 OTULIN ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 TRADD ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 CASP8 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN RACK1 TRAF1 ARHGEF3 ARHGEF4 ULK1 TNFRSF10B ARHGEF1 TNFRSF10A ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF TNFRSF10D ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 RBCK1 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 CHUK ECT2 ITGB3BP FAS ARHGEF33 FASLG NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 SHARPIN LINGO1 MAG OMG RTN4 HDAC2 UBE2D2 UBE2D3 IKBKE CASP2 STUB1 BAG4 UBE2D1 MAPKAPK2 UBA52 CYLD OTUD7B IKBKG UBB RIPK2 UBC RPS27A CASP10 TNF OPTN TAB3 TAB2 CASP3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 TASL HMGB1 CASP8 IRF5 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 TLR8 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling IL23R STAT3 IL23A RAP1B LMNB1 TCP1 CA1 STAT1 CDC42 CRLF1 CANX IL6ST IL27RA EBI3 HNRNPF IL27 P4HB SNRPA1 IFNG ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 JAK2 STAT4 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA PAK2 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP CTNNB1 IRF3 EP300 LRRFIP1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense SFN GBP1 CASP1 PIM1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation NR5A1 SRY SOX9 PTGDS DHH FGF9 WT1 AMH GATA4 DMRT1 ZFPM2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex PCNA MAX LIN52 CDC6 MYC HDAC1 E2F4 CDC25A E2F5 E2F1 RBBP4 TFDP1 TFDP2 LIN54 TOP2A LIN37 LIN9 RBL2 RBL1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB4 FGF2 THBS1 ITGB5 ITGA6 TNC TGFB1 VTN ACTN1 ITGA2 CASK SDC1 SDC4 ITGB3 ITGB1 SDC2 TRAPPC4 SDC3 ITGAV SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF BAIAP2 ABI2 ABI1 RICTOR ROCK1 ROCK2 PRKACG PRKACA PRKACB SPHK1 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 NOS3 PRR5 CRK PXN HSP90AA1 JUP PLCG1 SHB SH2D2A PIK3CB AXL NCK2 NCK1 RASA1 AKT2 PRKCZ PAK3 PRKCB RAC1 HRAS WASF3 BCAR1 VAV3 PDPK1 NRP1 PIK3CA ITGB3 VAV1 VAV2 TRIB3 MAPKAP1 ITGAV PIK3R2 PIK3R1 NRAS THEM4 RHOA CTNNB1 ELMO2 CDC42 MLST8 MTOR SHC2 HSPB1 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA FLT1 FLT4 NCF2 KDR NCF4 VEGFB PTK2B VEGFC VEGFD PGF BRK1 VEGFA MAPKAPK2 CTNND1 CTNNA1 CYBB CYBA MAPKAPK3 NRP2 CDH5 AAMP MAPK14 MAPK11 PAK1 AHCYL1 FYN NCKAP1L WASF1 PAK2 PTK2 WASF2 CAV1 AKT3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ARIH1 FURIN NPM1 OAS2 EIF2AK2 SPHK1 ISG15 MAP2K6 STAT1 FANCC PRKRA IRF3 TARBP2 MAVS RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 CENPX NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 FLNA PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 KPNB1 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B EIF4E2 FNTA FLNB MX2 DNAJC3 MX1 EIF4G3 EIF4G2 NCK1 EIF4A2 EIF4A1 UBE2L6 EIF4A3 HERC5 UBE2N ADAR PPP2R5A STAT3 HSPA1L DHX9 PIN1 HSPA2 CHUK MAPK3 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB PPP2CA PPP2CB EIF4E UBE2I SNCA GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 CASP1 NUP214 CENPS SFN ABCE1 UBE2E1 UBA52 CDK1 ILF3 JAK1 ACTB IKBKG UBB UBC PTPN2 RPS27A FAAP100 HSPA8 FAAP24 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation FGFR4 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B CHMP4A GABARAP CHMP2B CHMP2A UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A CHMP3 ATG12 ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B DYNLL2 TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 WIPI1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC25A10 SLC5A8 SLC5A12 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions COL4A2 COL18A1 COL4A1 ITGA5 ITGA3 ITGA9 COL16A1 ITGA1 ITGB8 COL13A1 ITGB5 ITGA6 JAM2 TNC JAM3 COMP IBSP SPP1 FBN1 ITGAX ITGB6 ITGA2 COL23A1 HSPG2 ITGA8 COL4A4 ITGA7 ITGAL COL4A3 VCAM1 LUM CD47 ITGA11 ITGA4 CD44 COL9A1 ITGAE COL9A3 PECAM1 COL9A2 AGRN ITGB7 CDH1 ITGAD KDR THBS1 FN1 VTN ITGA10 FGB FGA ITGAM ITGB2 FGG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 F11R BSG ITGB3 ITGB1 ITGA2B ITGAV PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening CACNB4 CACNG2 CACNA2D2 CACNG4 CACNA1B CACNA1A CACNA1E CACNB2 CACNA2D1 CACNA2D3 CACNB1 CACNB3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation FCGR1BP SEC61A2 SEC61A1 TIRAP TAPBP SEC22B B2M HLA-A TLR1 S100A9 PSMB10 S100A8 TLR2 FCGR1A STX4 CD14 TLR4 LY96 HMGB1 ITGAV HLA-H ITGB5 HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 CHUK LNPEP IKBKB MYD88 CD207 CALR CTSS MRC2 MRC1 VAMP8 PSMD8 PSMD6 TLR6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 NCF1 NCF2 PSMA5 NCF4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 CYBB FGA PSMB4 TAP2 CYBA FGG PSMB5 IKBKG TAP1 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSV CTSL FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGFBP3 FGFBP1 FGFBP2 FGF23 FGF22 FGF16 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis PCNA UBA52 POLH USP10 PCLAF USP43 REV1 ISG15 POLI UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling AKT2 PDE3B NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling OTUD5 ATG5 ATG12 UBE2D1 TRAF3 UBA52 UBE2K CYLD ITCH PIN1 IFIH1 ISG15 TRIM4 PCBP2 UBB UBC RPS27A NLRX1 TBK1 IRF3 NLRC5 UBA7 MAVS RNF125 RNF135 TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 UBE2L6 TRIM25 IKBKE HERC5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 CASP10 TP53 CASP6 ATM CASP1 CASP2 PIDD1 APAF1 NLRC4 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT6A CCT7 CCT4 CCT3 TCP1 ACTB CCT2 CCT8 CCT6B FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I POLR2J POLR2K POLR2L RBFOX2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 NCBP1 NCBP2 HNRNPA1 PTBP1 HNRNPM HNRNPF HNRNPH1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation PRKCB PRKCA STX4 PRKCG STXBP3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL11B SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A BCL7A DPF2 BCL7C BCL7B SMARCA4 SMARCC1 SMARCC2 ARID1A SMARCE1 ACTB RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling CREBBP RBPJ MAML2 MAML1 KAT2B KAT2A HES1 SNW1 EP300 JAG1 RUNX3 MAMLD1 MAML3 NOTCH1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand LIG1 PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression RXRA SP1 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B MYF5 TCF3 HELLS TCF12 KLF16 RARA SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM ADRM1 OAZ3 PAOX AZIN2 AZIN1 PSMC5 AGMAT PSMC6 SEM1 PSMC3 SMS PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNAT3 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 GNG12 GNG11 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A PIK3CA IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 PLD4 V2-19 V1-11 PLD3 V1-16 V1-13 PLD2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 PRKCD PLPP5 PLPP4 SYK AHCYL1 PRKCE DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses AP2A1 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 ARHGEF9 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 BCHE PRKCA SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT SLC6A1 CPLX1 RIMS1 ALDH5A1 DNAJC5 GIT1 HSPA8 VAMP2 CAMKK1 CAMKK2 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 SYN3 SYN2 HRAS SLC6A11 PDPK1 ARL6IP5 CACNA2D1 CACNA2D3 NRAS CHAT GRIP1 MAPK1 GNAT3 SLC6A4 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 SLC18A3 CHRNA1 CHRNA3 SLC17A7 CHRNA2 MAPK3 CHRNA5 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 GRIK4 GRIK1 GRIK2 GRIA1 GABRR3 CAMK2B GABRR2 GRIA2 GABRR1 CAMK2D NPTN SRC ACTN2 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B PICK1 NRGN GRIN2D GNAI3 AKAP5 GRIN1 GNAI1 DLG1 GRIN2A NCALD GNAI2 DLG2 CHRND DLG3 LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption MGAM SLC5A1 SLC2A5 SLC2A2 SI CLPS LCT PNLIP ALPI RSC1A1 PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF PIR PNLIPRP3 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLL1 DYNLL2 IFT172 KIFAP3 IFT52 IFT57 DYNC2H1 IFT140 WDR35 IFT88 KIF3A TTC21B WDR19 IFT122 KIF3B KIF3C DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 KIF17 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 TNPO1 CLUAP1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MTIF2 MRPS25 MTIF3 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MRPS17 MRPS15 MRPS16 MTFMT MRPS14 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME PON3 ABCB1 UGT1A3 SLCO1B1 SLCO1B3 PON1 ABCC2 CYP3A4 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA DDX21 ETF1 GSPT2 GSPT1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B UPF3A CNOT10 SMG1 SMG9 SMG7 SMG8 SMN2 SMG5 CNOT11 SMG6 UPF2 UPF1 PNRC2 NOP58 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 TYW5 GEMIN8 TYW3 TRMT5 DDX20 TYW2 TYW1 LCMT2 ADAR ADARB1 TNKS1BP1 RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPLP0 RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 LTV1 RRP1 GTF2H4 GTF2F2 FTSJ3 GTF2H5 EBNA1BP2 ISG20L2 CDK7 ERI1 ERCC3 LAS1L ERCC2 MNAT1 NOL12 RBM28 NOB1 RIOK2 RIOK1 TEX10 SENP3 GNL3 C1D NIP7 NOL9 EXOSC10 PES1 RIOK3 WDR18 WDR12 BYSL APOBEC1 BOP1 TSR1 APOBEC3C APOBEC2 MPHOSPH6 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B XRN2 HBS1L NT5C3B SKIC3 DCPS SKIC2 SLIRP MTPAP LRPPRC CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 NOP56 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PPP2R1A TP53RK STEEP1 TCERG1 EIF4A3 GPATCH1 RPS27 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 PRMT5 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 WDR77 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 PPP2CA ZRSR2 PRPF38A UPF3B NOP2 MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 TENT4A PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA LSM10 SNIP1 NCBP1 LSM11 MTREX NCBP2 TXNL4A PPP2R2A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 SEM1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 PHAX SNRNP27 PPIE TRUB2 SRSF3 MTERF3 SNRPE NSUN4 SRSF4 FASTKD2 PPIH MTERF4 PPIG SNRNP25 TFB1M SNRPF MRM1 SRSF5 MRM2 SNRNP200 MRM3 SRSF6 RCC1L SNRPC RPUSD4 SRSF7 NGRN SRSF8 RPUSD3 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 RPS4Y2 SNRNP48 RPS27L BUD13 RPS4Y1 TRMT10C PPIL3 PRORP PPIL4 RPS4X ELAC2 RPS15 FAM50A RPS14 TRNT1 HSD17B10 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 PAN2 PAN3 FASTKD5 POP5 TBRG4 POP7 CLNS1A OSGEPL1 SNUPN POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 DDX39B RPP38 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU EIF4E QNG1 EIF4B TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 GRSF1 NSUN6 DUS2 YWHAB QTRT1 HSPB1 GON7 ELAVL1 PSMD8 QTRT2 PSMD6 CTU2 ZFP36 CTU1 PSMD7 TSEN34 URM1 XPO1 PSMD2 LAGE3 KHSRP RPP14 PSMD3 TRDMT1 AKT1 RTRAF PSMD1 TRMT10A ADAT1 TNPO1 NUP214 TPRKB TRMT1 DIS3 PRKCD ADAT3 PRKCA TRIT1 ADAT2 YWHAZ PSMA5 XPOT PSMA6 TRMT6 PSMA3 FAM98B PSMA4 TRMT61A PSMA1 TRMT61B XRN1 RAN PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 CSNK1D EXOSC5 PSMB5 CSNK1E EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ZNF473 IGF2BP1 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 GAR1 NHP2 NOP10 DKC1 PELP1 ZC3H4 ZC3H3 EIF4A2 REXO2 IGF2BP3 EIF4A1 DDX49 TUT7 IGF2BP2 DDX47 TUT4 WDR3 DXO FCF1 ZCCHC7 NAT10 YTHDC1 THUMPD1 YTHDC2 PWP2 ZC3H18 WDR46 PNPT1 WDR43 RBM27 RRP9 RBM26 FBL TENT4B BUD23 SUPV3L1 UTP14A ZFC3H1 UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 PAIP1 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 RPLP1 DHX37 RPL34 RRP36 RPL10L UTP20 RPL8 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 UTP3 RPL18A PNO1 RPL36AL RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A WDR82 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 SKIC8 ZCCHC8 NCL TGS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP ACVRL1 BMPR2 AMHR2 GDF2 UBE2D1 SMAD9 SMAD5 GREM2 ZFYVE16 CER1 BMPR1B BMPR1A AMH NOG ACVR2B ACVR2A INHBA INHA CHRDL1 SKI SMAD1 SMAD4 SMURF2 SMAD7 SMURF1 SMAD6 TGFBR3 BMP2 UBE2D3 FSTL1 BMP10 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay ZFC3H1 PABPN1 SRRT TENT4A EXOSC7 EXOSC6 EXOSC5 EXOSC4 PAPOLG ZCCHC8 EXOSC9 NCBP1 MTREX NCBP2 C1D EXOSC8 EXOSC10 EXOSC3 EXOSC2 EXOSC1 RBM7 MPHOSPH6 ZC3H4 ZC3H3 WDR82 XRN2 DXO ZCCHC7 YTHDC1 YTHDC2 ZC3H18 RBM27 RBM26 TENT4B DIS3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis FTH1 FTL BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN AP3S1 TPD52 CLINT1 DNM2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 IGF2R DTNBP1 ARF1 GOLGB1 NAPA RAB5C TGOLN2 AP3B1 TXNDC5 OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SAE1 SUMO3 SUMO2 SUMO1 UBA2 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes HVCN1 KCNU1 CATSPERB CATSPER1 CATSPERD CATSPER3 CATSPERG CATSPER2 CATSPER4 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis CYP11B1 HSD3B2 HSD3B1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYP11B2 POMC SERPINA6 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP5 GP9 F9 F10 GGCX F8 GP1BA GP1BB F11 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex GPS2 NCOR2 NCOR1 TBL1XR1 TBL1X HDAC3 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes TLE1 TLE5 TLE3 TCF7L2 TCF7L1 CTBP2 HDAC1 CTBP1 LEF1 TLE4 TCF7 TLE2 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD OPLAH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNG13 GNB2 GNAQ GNB1 ADCY9 GNB4 PIK3R2 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB PECAM1 MLST8 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 PIK3CB CALCRL ADM TLN1 CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PIK3CA P2RY2 MMP14 GNG12 MAPKAP1 GNG11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MMGT1 ADD3 DMTN RHCG ADD2 ADD1 TUSC3 CTNS MAGT1 PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 RHAG AZGP1 ANKH MRS2 SLC66A1 NIPA1 NIPA2 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions IQGAP1 PIK3CB NCK2 PIK3R2 NCK1 PIK3R1 ACTN3 KIRREL3 ACTN2 KIRREL1 KIRREL2 ACTN1 MAGI2 FYN CD2AP SPTAN1 NPHS1 CASK WASL PIK3CA ACTN4 SPTBN1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX2 EHHADH ACBD5 AMACR ACOX3 SLC27A2 ACOT4 ACOXL NUDT7 CROT CRAT PECR HSD17B4 HACL1 ABCD1 DECR2 NUDT19 HAO2 ACBD4 ACAA1 PHYH ACOT8 SLC25A17 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling RELA MAP3K7 MAP2K6 IL1R1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 USP14 BTRC NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N NFKB1 CHUK IKBKB SQSTM1 MYD88 IRAK3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL1R2 PSMD13 NFKB2 TOLLIP PSMA7 PSMB6 PSMB7 PSMB4 MAP3K3 NKIRAS1 NKIRAS2 PSMB5 MAP3K8 IKBKG UBB IKBIP RIPK2 PSMB2 MAP2K4 PSMB3 IRAK4 UBC PSMB1 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism DMGDH CHDH SARDH ALDH7A1 BHMT SLC44A1 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) GP5 GP9 SERPING1 KLKB1 GP1BA F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression CXCL8 DCP2 HSPA5 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EIF2S2 EXOSC4 EIF2S1 EIF2S3 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP EIF2AK3 DIS3 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage IL18 CASP5 IL1B GSDMD CASP3 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis TPH2 DDC ASMT AANAT TPH1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs H2BC9 H2AZ2 POLR2A H4C9 POLR2B H2BC8 POLR2C H2BC5 POLR2D H2BC3 POLR2E RAN POLR2F H2BC1 POLR2G POLR2H POLR2I POLR2J H2AC20 POLR2K POLR2L IPO8 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B AGO1 H3C8 AGO2 H2AC8 TNRC6A H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling YWHAE NGFR NGF CASP2 BEX3 CASP3 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 SEPHS2 SECISBP2 EEFSEC RPS4Y2 SEPSECS RPS27L PSTK RPS4Y1 RPS4X RPS15 RPS14 RPS17 SARS1 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 PNPLA2 DGAT2 MGLL DGAT1 DGAT2L6 AWAT2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism PRSS1 TCN2 CD320 ABCC1 LDLRAP1 CTRB2 CUBN CBLIF MMAB CTRB1 AMN MMACHC MMADHC ABCD4 MTR MTRR LRP2 PRSS3 MMAA MMUT TCN1 LMBRD1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling CBL UBA52 FGF20 ANOS1 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET SOS1 ITGA3 STAT3 USP8 PIK3R1 NRAS PTPRJ RAP1B ITGA2 RAP1A STAM2 MET PTPN1 PTPN11 GGA3 SPINT1 HPN SPINT2 SRC HGFAC LRIG1 CRK LAMA5 SH3KBP1 LAMA2 LAMB3 LAMC3 CBL LAMB2 LAMA1 LAMA4 UBA52 LAMA3 LAMB1 STAM LAMC2 LAMC1 ARF6 RAB4A RAB4B DOCK7 HGS RANBP9 UBB RANBP10 RAPGEF1 UBC PTPN2 MUC20 RPS27A SH3GL3 EPS15 TNS4 SH3GL2 TNS3 SH3GL1 RAC1 HRAS GAB1 HGF PTK2 CRKL PIK3CA ITGB1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX CYP27A1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling GNG13 GNB2 GNAQ GNB1 PPP2R5D ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 MAPK1 GNGT2 GNAT3 PRKACG PRKACA PRKACB PLA2G4A PPP2CA PPP2CB GNA14 PPP1R1B PDE1B GNG3 PDE1A GNA15 CDK5 ITPR1 ITPR2 GNG2 CAMK2B ITPR3 GNG5 GNG4 CAMK2D GNG7 GNA11 GNG8 PDYN CAMK2A PDE4A PDE4D PDE4C GNAI3 GNAI1 GNAI2 OPRM1 CALM1 CAMK2G PRKCD PRKCA PLCB4 POMC PPP3CC PPP1CA PPP2R1B PPP2R1A PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX PPP3CA CAMKK1 PPP3CB CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 GNG10 NBEA PPP3R1 GNG12 GNG11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 FLRT1 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FLRT3 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FLRT2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis MBOAT7 MBOAT1 DDHD2 AGPAT2 MBOAT2 DDHD1 LPGAT1 PITPNB CPNE7 CPNE6 GPAM CPNE1 CPNE3 MFSD2A PISD PLA2G4A PLA1A PGS1 PTDSS2 PTDSS1 TMEM86B PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLA2G2A PLAAT5 PLAAT4 PNPLA8 LIPI LIPH ETNPPL PNPLA3 STARD7 PLB1 PLBD1 MIGA2 MIGA1 PLA2G3 PLA2G15 PHOSPHO1 PLA2G5 PLA2G10 PLA2G6 GPD1 PTPMT1 CHAT PLD4 PLD6 PLD3 CHKB CHKA STARD10 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 ACHE LPCAT1 PLD2 OSBPL10 ALPI GPD2 GNPAT PCTP LPIN1 LPIN2 MGLL PLA2G4F LPIN3 PLA2G4D PLA2G4E GPAT4 PLA2G4B PLA2G4C GPAT3 GPCPD1 CEPT1 AGPAT5 BCHE AGK PLA2G1B LPCAT4 AGPAT1 ETNK2 SELENOI LPCAT3 AGPAT3 ETNK1 AGPAT4 LPCAT2 LCLAT1 PLA2G2F PLA2G2D PLA2G2E PCYT2 PGP PLA2R1 CHPT1 GPD1L ABHD4 ABHD3 OSBPL8 CDS1 PITPNM1 PITPNM3 PNPLA2 OSBPL5 PITPNM2 CDIPT ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B AWAT2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 RXRB MYLIP REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors PHF20 AKT2 POU4F1 POU4F2 TP63 TP73 PPP1R13B TP53 PPP1R13L AKT1 TP53BP2 BANP AKT3 ZNF385A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling SOS1 PIK3R2 PIK3R1 KLRK1 NRAS PLCG1 BTK HLA-E GRAP2 LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 MYD88 TLR7 IRAK1 UBE2V1 TRAF6 IRF7 TLR9 UBE2N MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling RELA NGF SMPD2 IRAK1 ADAM17 NFKBIA ARHGDIA YWHAE TRAF6 PRDM4 BEX3 PRKCI TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ECT2 ITGB3BP ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 LINGO1 MAG OMG RTN4 HDAC2 CASP2 UBA52 UBB RIPK2 UBC RPS27A CASP3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling ATP5MC2 ATP5MC3 ATP5PB ATP5F1C ATP5MK ATP5F1D MT-ATP8 ATP5MJ ATP5F1E MT-ATP6 ATP5MC1 ATP5MG ATP5PO ATP5MF ATP5ME DMAC2L ATP5F1A ATP5F1B ATP5PF ATP5PD MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling PIK3CB SOS1 ANGPT4 SHC1 ANGPT2 ANGPT1 PIK3R2 PIK3R1 TEK DOK2 NRAS HRAS GRB7 PIK3CA PTPN11 GRB14 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER PREB STX5 LMAN2 FOLR1 CTSZ SEC24D CTSC SEC24C COL7A1 SAR1B MIA3 TMED10 SEC22B TMED2 SEC23A SERPINA1 AREG GRIA1 GOSR2 LMAN1 LMAN1L LMAN2L CD59 TGFA F5 F8 CNIH1 SEC24B CNIH2 CNIH3 MCFD2 SEC24A MIA2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A UPF1 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 NCBP1 RPS19 NCBP2 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants ERBIN SOS1 HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants KIT PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion UBC RPS27A RAB7A VPS33B CORO1A HGS RAB5A UBA52 UBB LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis AKR1B15 HSD17B14 HSD17B11 HSD17B1 HSD17B2 CYP19A1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC APPL1 DCC UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 CASP3 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 STAT5A STAT5B CBL CDKN1A PIK3R1 GRB2 NRAS UBA52 GOLGB1 MYO18A FLT3 ETV6 UBB PTPN11 UBC RPS27A BCL2L1 TRIP11 PIM1 HRAS ZMYM2 FLT3LG GAB2 PIK3CA SPTBN1 NOX4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 PTGR1 CYP4A22 CYP4B1 ALOX5AP MAPKAPK2 DPEP2 DPEP1 GGT1 ABCC1 ALOX15 CYP4F22 ALOX5 LTA4H LTC4S CYP4F3 CYP4F8 CYP4F2 CYP4A11 CYP4F11 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 RHOC CDKN1B PPP1R12A RHOA RHOB RAC1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 PPP1R12B DLG4 PPP1CB PRC1 CIT CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage IL18 IL1B CASP4 GSDMD CASP3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 GLTP CPTP CLN3 ESYT1 ARF1 ESYT3 ESYT2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC26A2 SLC22A5 GCKR SLC5A1 GCK SLC5A2 SLCO1B1 SLCO1B3 CP SLC6A5 SLC2A9 SLC67A1 SLC26A4 SLC26A3 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH AVPR1B SLC2A10 AVPR2 AVPR1A SLC24A4 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C SLC5A5 NUP42 NUP85 TPR NUP62 SLC35C1 NUP88 NUP43 RAE1 NDC1 SLC20A2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC24A1 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC17A5 SLC35A2 SLC35A3 SLC9A6 SLC33A1 AVP SLC9A9 SLC35A1 SLC29A3 SLC6A19 SLC4A1 SLC36A2 SLC27A4 SLC4A4 BSG SLC6A14 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC7A7 SLC5A7 SLC7A9 SLCO2A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 CSK HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 PTPRC HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 PAG1 HLA-DQB2 HLA-DQB1 LCK P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR NGF PRDM4 HDAC1 HDAC2 HDAC3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC5 HDAC1 HDAC3 HDAC8 HDAC9 HDAC6 HDAC7 MAMLD1 TBL1X RBPJ CREBBP MAML2 NCOR2 MAML1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 SNW1 HDAC11 HDAC4 HDAC2 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate TST ETHE1 SLC25A10 TSTD1 SQOR SUOX DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 APOA1 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 TLR4 HNRNPA1 STAT2 LY96 MAPKAP1 PDCD6IP FASN C4BPA C4BPB ATG14 HSP90AB1 CTNNB1 C4B_2 SDC4 SDC2 SDC3 RPTOR MLST8 GPC1 GPC3 UBE2I GPC2 GPC5 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H2AC25 NEK2 H2AC21 GTF2F1 GTF2F2 IFIH1 HSPA8 UBR4 NRBP1 PEX19 HNRNPA0 CD2BP2 HNRNPUL1 AUP1 PPIL6 ELAVL2 RICTOR H2AC1 CPSF7 SRRM1 VIM HNRNPC RIPK1 RBMX STING1 NFKBIA MAVS CLEC5A HSP90AA1 H2BC18 BECN1 DAXX H2AC19 H2BC26 H2AC14 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 CDC40 H2AC20 DHX9 HSPG2 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 SF3A1 SF3A2 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN WBP11 PRPF6 SNRPG SRSF2 PPIE NFKBIB SRSF3 F2 SNRPE SRSF4 SNRPF SRSF5 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNG13 GNB2 GNAQ GNB1 KCNJ11 ABCC8 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ACACB ADCY6 ADCY5 GNGT2 RAP1A PRKACG SLC2A1 SLC2A2 PRKACA PRKACB RAPGEF3 FFAR1 RAPGEF4 GNA14 GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 IQGAP1 GNAS GCGR GCG CHRM3 PPP2R1B PPP2R1A ACACA PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 CACNB2 PLCB3 PLCB1 PLCB2 ACSL4 ACSL3 ACLY CACNA1D FASN PPP2R5D STXBP1 INS ADRA2C SYT5 MLX ADRA2A PRKAA2 CACNB3 PRKAG2 PPP2CA STK11 PPP2CB CACNA1A CACNA1E STX1A TKT PRKAB2 KCNG2 AKAP5 GNAI1 GNAI2 AGPAT1 PRKCA CD36 SNAP25 KCNC2 CACNA1C PFKFB1 GLP1R ADIPOQ MLXIPL ADIPOR1 ADIPOR2 TALDO1 KCNB1 KCNS3 VAMP2 AHCYL1 MARCKS GNG10 GNG12 GNG11 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation PSMB3 PSMA5 PSMA6 PSMB1 PSMA3 PSMA4 PSMA1 PSMA2 PSME2 PSMB10 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB8 PSMB9 PSMB5 PSMB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC12 MUC17 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD TBXAS1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CBLL1 CTNNB1 RPS27A CDH1 CTNND1 UBA52 SRC UBB ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A4 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis SEL1L IHH VCP DERL2 ERLEC1 OS9 ADAM17 GPC5 P4HB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 DISP2 PSMC2 SCUBE2 NOTUM SYVN1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins ISCU RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants HRAS NF1 SPRED3 SPRED2 SPRED1 NRAS DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS NCAN CSPG4 CHSY1 BGN DCN BCAN VCAN CSPG5 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 PRSS3 CTRB2 CUBN TCN1 CBLIF CTRB1 AMN LMBRD1 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL HADHB HADHA PLA2G6 PLA2G4A LCLAT1 TAFAZZIN LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism ALDH4A1 PRODH PRODH2 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) VAMP2 SV2C SV2B SV2A VAMP1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism ADA2 SFTPB SFTA3 SFTPA1 ZDHHC2 SFTPA2 CTSH ADRA2C TTF1 ADRA2A DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 ADORA2B ABCA3 GATA6 ADORA2A CKAP4 SFTPD P2RY2 SLC34A2 SFTPC SLC34A1 CSF2RB CSF2RA ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide CA4 AQP1 HBA2 SLC4A1 CA1 RHAG CA2 HBB DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE ABCC6 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 FPR1 FPR3 APP SAA1 FPR2 HEBP1 ANXA1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 TGFB1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SMURF2 EP300 SMURF1 ADRM1 SRC MDM2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 RUNX3 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 CBFB IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 TRAV29DV5 IGLC3 TRBV7-9 TRBC1 IGLC1 IGLC2 IGKV3D-20 TRAV19 IGKV2-30 IGLV3-19 IGHV2-70 TRAV8-4 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 HLA-H HLA-B V2-11 HLA-C V3-4 HLA-F V3-3 V2-17 HLA-G HLA-E V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 CD19 V2-8 V1-20 TREM2 V1-9 V5-4 V1-7 V5-1 CDH1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD40LG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 C3 VCAM1 SIGLEC9 CXADR ITGB7 B2M HLA-A CD8B SIGLEC5 FCGR1A JAML CD99 ITGB2 COLEC12 ITGB1 CD33 ITGAL ITGA4 LILRA3 IFITM1 CD226 CD1D CD1C CD1B cd21 LAIR1 CD1A SLAMF7 LILRB2 SLAMF6 LILRB3 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD22 CD200 CD300A NCR1 NCR3 CD200R1 OSCAR HCST TYROBP LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 SELL KLRK1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 NCR2 SIGLEC1 SIGLEC8 KIR2DS2 SIGLEC7 SIGLEC6 PVR CD96 CD300LB CD8A TREM1 KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 CD300E KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 KLRD1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 CLEC2B FCGR2B CLEC2D NECTIN2 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRND CHRNA3 CHRNA4 CHRNG CHRNE PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UCK1 PUDP TK2 TK1 CDA DCK UPP2 UPP1 TYMP UCKL1 UCK2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCK ZAP70 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM12 ADAM19 SH3PXD2A TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 TICAM1 TLR3 RIPK3 CASP8 FADD SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin PRKCA HRAS SOS1 MMP3 HBEGF EGFR NRAS PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNQ1 CACNG4 KCNE5 AKAP9 CACNG6 CACNG7 CACNA1C CACNA2D2 CACNB2 CACNG8 CACNB1 KCNE1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 SPTAN1 POMT2 FYB1 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 ACTN3 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 CASK FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A IQGAP1 JUP RB1 RBBP4 WASL RBBP7 H2AX PIK3CB KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L NCK2 H2BC21 NCK1 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 SIRPG SKAP2 PIK3CA BANP SPTBN1 ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 H2AC20 KIRREL3 KIRREL1 KDM1A KIRREL2 MAPK1 MAGI2 CD2AP NPHS1 MAPK3 PTPN11 CD47 HDAC2 SRC ACTN2 SUZ12 SIRPA ARID1A TYROBP PTK2B PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 SIRPB1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 PTPN6 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 FYN SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 PTK2 CTSL NECTIN1 ACTN4 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 GUCY1B2 KCNMB4 GUCY1B1 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE5A NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis IMPDH1 ADSL IMPDH2 PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS CAD DHODH UMPS ATIC SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants FLT3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand ACD PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 RPA3 WRN DNA2 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin STAT5A STAT5B JAK2 LEP STAT3 SOCS3 IRS1 PTPN11 IRS2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors ZFP36L2 PAIP1 PABPC1 CNOT4 CNOT6 CNOT7 EIF4E EIF4B DICER1 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 BTG4 CNOT6L CNOT11 EIF4A2 EIF4A1 EIF4G1 PABPN1L EIF4A3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 STAM2 STON1 GPS1 STON2 COPS4 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 SGIP1 AP2S1 AGTR1 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 APOB SNAP91 M6PR SYT2 ARRB1 ARRB2 SCARB2 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 TGOLN2 CHRM2 HGS CD4 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 SLC18A3 DAB2 EPS15L1 EPN1 SYT9 GRK3 PICALM VAMP8 IL7R TFRC CFTR SYT1 IGF2R UBA52 STAM UBB UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG BTC EPGN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9 CYP2C8 CYP2J2 CYP1A2 CYP1A1 CYP1B1 EPHX2 CYP2C19 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GCGR ADCY7 ADCY6 GCG ADCY5 PRKACG PRKACA PRKACB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling APOA1 APOA4 APOB APOA5 GPIHBP1 APOE APOC2 APOC3 LPL APOA2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 CDH11 AGO1 AGO2 TNRC6A TNRC6B CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia CITED2 CA9 ARNT HIF1AN UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 VEGFA PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC HIGD1A PSMB1 RPS27A EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EPO DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) FMOD PRELP B4GALT1 OMD KERA ACAN OGN LUM SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants FLT3 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CSNK2A1 CLOCK DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l ALG9 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 GYG2 GYS2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system JUN TRIM6 IFNA2 TRIM5 TRIM2 IFNA8 TRIM3 CSH1 XAF1 ARIH1 RELA IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 TRIM45 NPM1 TRIM35 TRIM38 TRIM31 OAS2 TRIM34 IFITM3 IFNA10 IFITM2 IFIT5 IFNA21 IFI35 IFI30 IFIT3 IFNB1 EIF2AK2 IFIT2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR IRF8 IRAK1 IRF6 IRF9 SAMHD1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A KPNB1 IL1B KRAS PELI1 MMP1 FNTA MMP2 DNAJC3 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N ADAR IRF1 IRF2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 HSPA1L HSPA2 MAPK8 ATF6 BCL2L11 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 FCER2 CANX UBE2I PTGS2 SUMO1 ALOX5 UBE2D2 UBE2D3 ELOB ELOC RBX1 TRIM25 SDC1 HIF1A GH1 SNAP25 GATA3 LYN INPP5D TNFRSF12A TNFSF12 TNFRSF13C ARF1 TNFRSF11A CD40LG RALA RPLP0 LTBR IL1RN PITPNA LTB BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IFIH1 IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ACTB ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA KPNA2 TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 KPNA7 FKBP5 KPNA4 KPNA5 CSF1R GBP1 KPNA3 MAP3K7 FPR1 SPHK1 MAP2K6 TCP1 MT2A FANCC BCL6 SMAD3 SMAD7 ADAM17 NFKBIA MAVS TAB1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TRAF2 NUP43 RAE1 KPNA1 ILF2 NDC1 TRAF3 RANBP2 TEC TRAF6 SEC13 BIRC2 NUP155 NUP133 NUP210 BIRC3 NUP153 NUP93 USP14 BECN1 NUP50 NUP35 NUP54 NUP37 NOD1 ITGAM ITGB2 ACTG1 FLT3 NOD2 IRS1 USP18 PPP2R1B IRS2 EIF4E3 PPP2R1A PIK3CB IFIT1 PPM1B PML EIF4E2 FLNB FGF2 TNFRSF1B MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 SOX2 TNIP2 GRB10 HRAS PTPN13 INPPL1 FLT3LG TWIST1 IRF5 EIF4A3 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5A SHC1 PPP2R5D PIK3R2 PIK3R1 BST2 NRAS RHOU ALOX15 PTPRJ MAPK1 BIRC5 DHX9 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CDC42 LIFR CD44 PPP2CA PPP2CB CAMK2B HNRNPF CAMK2D SRC CAMK2A CASP1 OPRM1 EIF2AK3 CAMK2G CENPS IFNG UBE2E1 MCL1 CD86 PTK2B UBE2D1 CD80 VEGFA CDK1 IL22 POMC CXCL1 NFKB2 CSK JAK2 HNRNPA2B1 ILF3 IL2RG MMP9 FBXW11 THOC5 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B HSPA5 CCL3L3 CCR5 RAF1 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 YBX1 PRKRA TARBP2 IFNAR1 P4HB PRTN3 TIMP1 POU2F1 PLCG2 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FLNA FN1 BRWD1 BLNK GRAP2 HLA-DQA2 BTRC S1PR1 HLA-DQA1 JAK3 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCN2 STAT2 MMP3 UBE2L6 HERC5 IL23R IL13RA2 IL13RA1 HLA-H IL4R IL23A CDKN1A FSCN1 HLA-B NDN HLA-C LIF NANOG HLA-F HLA-G IGHE HLA-E OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 EIF2S2 ATF2 STX3 EIF2S1 IL10RB EIF2S3 CLCF1 EGR1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C EIF4E IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 GBP5 IL11 PIM1 IL19 IL16 DUS2 PGGT1B IL17RE GBP2 OSMR GBP4 PSMD8 IL17RB GBP3 PSMD6 HMOX1 IL31 SLA IL17C SLA2 PSMD7 IL11RA SOCS2 IL7 PSMD2 SOCS6 IL7R SH2B3 IFNL2 PSMD3 IFNL1 AKT1 IRF7 IFNL3 PSMD1 PSMB8 NUP214 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A FAAP100 UBE2V1 FAAP24 HSPA8 VAMP2 CUL5 ICAM1 TNFSF13 FAAP20 FANCM ADRM1 UBA7 FANCL MAPK14 FANCA MAPK11 PSMC5 FANCB PSMC6 FANCE PSMC3 FANCG PSMC4 FANCF PSMC1 PSMC2 ABL2 HSPA1A EIF4G1 PAK2 RAG2 RAG1 IL32 CASP3 FURIN UBA3 IL34 IL1RL1 GAB3 IL33 TGFB1 UBE2M FCGR1BP LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 B2M RELB IRF3 MAP3K14 HLA-A RNF7 TRIM21 GBP6 RORC RORA TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A FCGR1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 CENPX TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 HSP90AA1 NEDD4 TNFSF4 LTA CBL CD27 TNFSF9 PLCG1 TNFRSF25 TNFSF8 CDKN1B PDE12 OASL OAS1 FNTB OAS3 RNASEL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 EIF4A2 EIF4A1 MAP2K1 HSP90B1 H3C15 NCAM1 STAT3 NFKB1 ITGAX PIN1 FASLG TNFRSF18 PRL IFITM1 PIAS1 SNCA IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 ABCE1 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 AKT3 TRIM8 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CUBN CBLIF AMN HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) ABL1 RAD52 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 RAD50 RAD51 RPA3 RAD17 RAD1 ATM ERCC4 DNA2 ERCC1 RAD9B RHNO1 ATR RAD9A TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins PRKCSH UBA52 GANAB ST6GALNAC3 ST6GALNAC4 MGAT1 GALNT1 MOGS UBB UBC ST3GAL4 CANX RPS27A ST3GAL1 ST3GAL2 UBE2I ST3GAL3 SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 PARP14 PARP8 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle TFRC KIF14 KIDINS220 DSG1 NUDC VANGL1 ARHGAP1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 PLXND1 PRAG1 TXNL1 ALDH3A2 PKP4 ANKRD26 LEMD3 DEPDC1B RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 BLTP3B TNFAIP1 RND2 PTPN13 NISCH GOLGA3 KTN1 CKAP4 FNBP1 KCTD13 FRS2 SCRIB VANGL2 LRRC1 CAV1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 NECTIN2 CADM3 CADM1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation PLK3 PIN1 CDK2 PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 PRKAG2 PRKAG3 NOC2L STK11 TAF7L CDK5 PRKAB2 TP53INP1 MDM2 PRKAB1 MDM4 TAF4B DYRK2 TBP UBA52 TAF9 TAF1L AURKA TAF15 HIPK1 TAF12 BLM TAF13 MRE11 MAPKAPK5 HIPK2 BRCA1 TAF11 WRN BRIP1 TAF8 KAT5 TAF7 EXO1 CHEK1 TAF6 RBBP8 TAF5 NBN UBB TAF4 TOPBP1 TAF3 SUPT16H ATRIP TAF2 BARD1 TAF1 RFC5 UBC RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TAF10 TP53RK TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CHEK2 CSNK2A2 TAF9B RAD50 CSNK2B RPA3 RAD17 CCNA2 TP53 RAD1 CCNA1 ATM DNA2 NUAK1 RAD9B RHNO1 ATR RAD9A TPX2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 ATP6V0D1 TFRC HFE ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 TF TCIRG1 STEAP3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 MCOLN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols RXRA CYP51A1 NCOA2 CYP19A1 POMC ARNT2 CYP7B1 CYP11A1 NCOA1 CYP7A1 CYP1B1 CYP27A1 CYP39A1 CYP11B2 CYP11B1 ARNT CYP21A2 AHRR FDXR CYP8B1 NR1H4 CYP46A1 CYP4V2 FDX1 FDX2 AHR RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 TAX1BP3 RHPN2 RTKN RHOC LIN7B ROPN1 RHOA RHOB DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription KLF4 SP1 TFAP2A ZEB2 FOXP2 FOXJ2 STRAP KLF9 ARID1A FOXA2 RB1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 IL25 TAB1 IL17RE IL17RB IL17C IL17RC IL17RA IL17F IL17A MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts RXRA OSBP NCOA2 AMACR SLC27A2 SLC27A5 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 NCOA1 CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 OSBPL1A ABCB11 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 ESPL1 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A PTTG1 KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMD8 CENPI PSMD6 TAOK1 CENPK PSMD7 CENPL XPO1 CENPM PSMD2 CENPN B9D2 PSMD3 CENPO CENPP PSMD1 CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PSMA5 PLK1 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CLIP1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling ITGA3 LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 SRC LAMB1 LAMC2 LAMC1 ITGA2 MET HGF PTK2 ITGB1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation SOX17 TBX6 POU3F1 YAP1 POU5F1 PAX6 MAMLD1 FOXC2 CXCR4 FOXC1 IHH PAX2 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD4 GSC SMAD3 MIXL1 PAX3 ZNF521 FOXA2 FGFR1 MAML2 DLX5 MAML1 FGF2 FGF4 MYB EP300 SOX2 GATA6 TBXT EOMES MAML3 NOTCH1 BMP4 TCF7L2 TCF7L1 NANOG LEF1 TCF7 ZIC1 CTNNB1 RBPJ TFAP2A TFAP2B CDH1 SNW1 TFAP2C EPHA4 TEAD2 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TBPL2 GATA4 MSX1 PSMA5 OSR1 PSMA6 PSMA3 ZIC2 PSMA4 PSMA1 TRIM33 PSMA2 PAX8 PAX7 PSMD12 PSMD11 NOG PSMD14 NOTO FOXH1 PSMD13 FOXF1 WNT3A PSMA7 PSMB6 SHH ZEB2 PSMB7 SNAI1 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP PSMB1 KAT2B KAT2A LFNG ADRM1 LHX1 PSMC5 PSMC6 SEM1 DLL1 PSMC3 PSMC4 PSMC1 FOXA1 PSMC2 FGF8 SOX1 GBX2 OTX2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation CLTC CLTA AP2A1 AP2A2 KIF5C AP2M1 KIFAP3 KLC1 KLC4 KLC3 KLC2 IFI30 SAR1B KIF3A KIF3B AP2S1 AP1G1 AP1S2 KIF3C SEC23A AP1S1 KIF5B AP1S3 KIF5A AP1M2 KIF4B AP1M1 AP2B1 HLA-DOA AP1B1 KIF4A HLA-DOB LAG3 KIF11 CTSO CTSF CTSE HLA-DMA HLA-DMB KIF15 RILP CD74 SEC24B SEC24A KIF22 SEC13 HLA-DQA2 SEC24D HLA-DQA1 HLA-DPA1 HLA-DRB5 SEC24C HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 DYNC1LI1 CAPZB DYNC1LI2 KIF26A CTSD KIF23 KIF20A KIF18A DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A ACTR1B CTSH CTSC KIF2C KIF2B CAPZA3 DNM1 CAPZA2 DNM2 DYNC1I2 LGMN ACTR10 SEC31A CANX DYNC1I1 DYNC1H1 CTSS CENPE DNM3 SPTBN2 ACTR1A ARF1 OSBPL1A RAB7A SH3GL2 DCTN2 CAPZA1 DCTN3 CTSA RACGAP1 CTSB CTSV CTSL CTSK ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A8 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 PTEN AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol PLCB4 INPP5D PLCG1 PLD4 OCRL INPP5B SYNJ1 PLCZ1 INPP5J PLCE1 ITPK1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC25A5 SLC28A3 SLC25A4 SLC25A6 ARL2 ARL2BP SLC29A4 SLC28A2 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation DOHH EIF5A DHPS EIF5A2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 ACADS HADH CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A COPS3 COPS6 COPS5 COPS8 CHMP3 CHMP6 CHMP7 PLA2G6 DCTN6 DCTN5 DCTN1 GJC1 DCTN4 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 MAN2A1 GJA9 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CHM TMED2 CD59 DNM3 CD55 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 COG8 COG7 COG6 COG5 COG4 COG3 RAB27B COG2 COG1 RINT1 RAB30 RAB36 TF KIF16B SAR1B KDELR2 KIF20B COPB2 COPA TMED10 ARL1 AP2S1 KIF3B AGTR1 MAN2A2 VTI1A LDLR SERPINA1 KIF3C RAB6B RAB39A KIF18B KIF4B AP2B1 ALPP KIF4A COPE KIF12 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 MAN1A2 F5 KIF13B F8 TMED3 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 STX4 KIF6 BET1L KIF27 COPZ1 SH3KBP1 SLC2A8 RAB33B KIF9 KIFC2 KIFC1 CD3G NAA35 CD3D NAA38 VAMP4 PAFAH1B3 ARF5 NAPA NAPB NBAS CHRM2 TMF1 STX16 STX18 GOSR1 GOLGA2 NAPG STX10 CYTH3 ARFRP1 CYTH2 CYTH4 CUX1 VPS51 CD4 VPS53 VPS52 MAN1C1 BNIP1 STX6 VPS54 CYTH1 RIC1 MYO1C GALNT2 ARCN1 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 SNX2 FNBP1L SNX9 SNX5 TBC1D8B PUM1 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 KIF20A TMEM115 CNIH2 CNIH3 MCFD2 MIA2 PPP6R1 TRAPPC6A FTH1 TRAPPC6B SEC22A SEC22C FTL STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF PLIN3 GGA2 GGA1 GGA3 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 TGFA EREG BTC EPGN AKT3 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria AUH DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM MMAA MMUT SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAH YWHAZ SFN SP1 SMAD4 SMAD3 EP300 UBE2I YWHAB PSMC6 YWHAE PDPK1 YWHAQ CAV1 YWHAG FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation FGFBP3 FGFBP1 FGFBP2 FGF1 FGF10 FGF2 FGF3 FGF22 FGF7 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 FRS3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 PIK3C2A MTMR9 MTMR4 MTM1 PIK3R4 FIG4 MTMR7 PIKFYVE PIK3C3 VAC14 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium UNC119B ARL3 CYS1 NPHP3 RP2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway TRAF2 TNFSF10 TNFRSF10B UNC5A TNFRSF10A DAPK1 UNC5B DAPK2 DAPK3 FADD CD14 MAGED1 APPL1 FAS FASLG TLR4 RIPK1 TICAM2 DCC TICAM1 LY96 TRADD CASP8 CASP9 CASP3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine MAOA TOMT SLC6A3 COMT REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling XIAP RACK1 STUB1 TRAF1 UBE2L3 TRAF2 UBE2D1 ULK1 MAPKAPK2 FADD USP4 UBA52 BIRC2 USP2 BIRC3 MIB2 CYLD SPPL2B SPPL2A CLIP3 RBCK1 OTUD7B CHUK IKBKG UBB IKBKB RIPK1 UBC RPS27A USP21 SHARPIN TNF TBK1 OTULIN OPTN TAX1BP1 UBE2D2 UBE2D3 TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA AREG EGF EGFR EREG BTC EPGN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin FST FSTL3 INHBB INHBA SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins RANGAP1 UBE2I SUMO1 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOA1 APOE APOC2 APOC3 LIPG ALB CETP ABCG1 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB SESN2 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SEC13 SZT2 SAMTOR SEH1L NPRL2 NPRL3 TCIRG1 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 ATP6V1E1 FNIP2 KICS2 ATP6V1E2 CASTOR1 CASTOR2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 HRAS FGF18 SOS1 FGF1 FGF2 FGF23 FGF4 FGF9 NRAS FGF20 FGF16 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency TCN2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase CEP41 TUBGCP4 CEP43 TUBA1A PRKACA SMC4 SMC2 YWHAE TUBB4B TUBB4A NUP107 EML4 CDCA5 NUP160 NCAPG YWHAG NCAPH NUP85 NUP43 HSP90AA1 NCAPD2 RANBP2 SEC13 NUP133 NUMA1 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 CPAP KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PRKAR2B PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CCP110 CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 TUBG1 HAUS2 HAUS1 MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 CSNK2A1 DCTN3 HAUS8 HAUS7 CSNK2A2 CEP70 CEP72 CEP192 TUBA4A PCNT CSNK2B CEP76 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 NEK7 MZT1 NEDD1 ALMS1 TUBGCP5 CLIP1 TUBGCP6 TUBGCP3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDKN1A POT1 TERF2IP H2AC20 HMGA2 H1-1 H1-0 H1-3 CDK2 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A RB1 CDKN1B HMGA1 MRE11 KAT5 CCNE2 CCNE1 H2AX NBN H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 CCNA2 TP53 CCNA1 H2BC11 ATM HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation GUSB CD44 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HYAL2 HEXB HEXA CHP1 SPAM1 HYAL1 HYAL3 HYAL4 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion F8 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) GGPS1 RXRA SCD CYP51A1 FASN LSS SREBF2 SQLE MTF1 DHCR7 ACACB GPAM NFYA NFYB NFYC TBL1X NCOA1 SAR1B SEC23A TBL1XR1 MBTPS1 SCAP MBTPS2 SEC24B SEC24A NCOA2 NCOA6 RAN INSIG2 SMARCD3 INSIG1 SEC24D MVD SEC24C CARM1 KPNB1 HELZ2 CREBBP CHD9 SP1 ACACA MED1 TGS1 IDI1 ELOVL6 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses C4A CLEC5A C4BPA C4BPB CDC73 EXOC1 HSP90AA1 SKIC8 DDX3X HSP90AB1 CTR9 CLU RTF1 VTN APOA1 LEO1 PAF1 IFIH1 C4B_2 CGAS RBM10 STAT2 STING1 MAVS UBR4 C1QA C1S MBL2 TRIM25 IKBKE PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 PAX4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI TRPC7 TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport TTPA RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H HDAC1 POLR2K POLR2L MTA2 GTF2H1 ERCC6 GTF2H2 GTF2H3 RBBP4 MTA1 GTF2H4 MBD3 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 RRN3 ERCC2 MNAT1 EHMT2 GATAD2B GATAD2A CHD3 KAT2B KAT2A HDAC2 UBTF POLR1A POLR1B CHD4 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism GNG13 CGA GNB1 TCF7L2 GNB3 KIF5C INS CTSZ SLC30A8 PCSK1 GNAT3 GPR119 SLC30A5 PAX6 CPB2 ISL1 GIP CTSG FSHB DPP4 CTNNB1 INHBB IGF1 SPCS3 INHBA SPCS2 SPCS1 INHA FFAR1 INHBC SEC11A INHBE SEC11C ACHE LHB ACE2 STX1A KIF5B KIF5A P4HB BCHE PCSK2 ERO1B CGB8 CPA3 MME CDX2 ENPEP AGT LEP EXOC8 CPB1 FFAR4 EXOC7 CLTRN ACE UCN CES1 CPE GATA4 MBOAT4 REN PLA2G7 CRHR2 GH1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GRP TSHB CMA1 GCG POMC ATP6AP2 KLF4 MYO5A RAB27A VAMP2 MYRIP CTSD ANPEP GZMH PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism PAH ASRGL1 KYAT1 QDPR IL4I1 PCBD1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription RUNX3 SMAD4 SMAD3 TP53 CDKN1A ZFHX3 TGFB1 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 CLTC RPS6KA1 CLTA AP2A1 AP2A2 AP2M1 RDX MAPK1 NUMB DNM1 DNM2 MSN AP2S1 SH3GL2 RPS6KA4 KIF4B AP2B1 KIF4A SHTN1 DNM3 RPS6KA6 EZR RPS6KA3 RPS6KA5 L1CAM DPYSL2 RPS6KA2 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins HERC2 XRCC4 PARP1 CDKN2A RAD52 MDC1 SP100 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 PIAS4 NSMCE3 NSMCE2 NUP88 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 CETN2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 BLM BRCA1 NUP37 WRN PML RPA1 SMC1A XPC SMC3 STAG1 STAG2 RAD21 TDG SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions SLCO4A1 SLCO2B1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A1 SLC25A10 SLC13A2 SLC22A12 SLC13A3 SLCO1C1 SLC5A12 SLC16A7 SLCO1A2 SLC16A8 EMB SLC13A5 SLC16A3 SLC17A5 SLC16A1 AVP SLC22A7 SLC22A6 SLC22A8 SLC10A6 SLC5A8 SLCO4C1 BSG SLC44A5 SLC44A3 SLC22A11 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLCO2A1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 CRY2 CRY1 ADRM1 FBXL21P PSMC5 PSMC6 PER2 SEM1 PSMC3 PER1 PSMC4 PER3 PSMC1 PSMC2 SKP1 CUL1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland PRL FGF10 TGFA AREG EGF FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 SGF29 NCOA6 KANSL1 PHF20L1 KANSL2 SETD1B KANSL3 SETD1A RBBP5 KMT2D PHF20 BOD1L1 ASH2L MBIP TASP1 KMT2C DR1 KMT2B BOD1 KAT2B KAT2A YEATS2 AKAP8L MEN1 TADA3 PAGR1 KAT8 OGT HCFC2 WDR82 PAXIP1 KDM6A DPY30 KAT14 MCRS1 WDR5 KMT2A PSIP1 ZZZ3 HCFC1 TADA2A DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 GALM CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane F8 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis PCSK1 CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE POMC RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants HRAS NRAS KRAS MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development RPS6KA1 EDNRB ASAH1 DICER1 TRPM1 PAX3 YWHAE SNAI2 TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 PXN SMARCD1 SMARCD2 SMARCD3 RARS1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 SMARCE1 MC4R DARS1 EEF1E1 LIG1 MC3R KARS1 GMPR IARS1 EP300 MC5R SOX2 AKT2 ATP6V1E1 SOX9 ATP6V1G1 ATP6V0B ATP6V0E1 KIT DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H ZIC1 FOXD3 MAPK1 TBX2 HINT1 TFE3 CCND1 MITF ITGA2 SIN3A TFEC ALX3 CDK2 TBX3 CTNNB1 MET ATP6V1C1 GPR143 MAPK3 EPRS1 TNRC6C MOV10 ID1 TFAP2A AGO3 STT3B AGO4 CDH1 UBE2I AGO1 AGO2 DPF1 SUMO1 TNRC6A TNRC6B DPF2 YWHAB DPF3 XPO1 SS18L1 ARID1A GSK3B ARID1B YWHAZ PPARGC1A PLK1 SS18 SMARCB1 CCNB1 POMC WNT3A SOX10 SMARCC1 BRCA1 SMARCC2 MARK3 ACTB ACTL6A CREBBP GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TFEB TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 AKT3 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK2 PANK3 PANK1 DCAKD DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex FRAT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 TCF7L1 HDAC1 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 PPP2CA PPP2CB PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 TLE5 APC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CTBP2 CTBP1 PSMB5 PPP2R1B UBB PPP2R1A PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TLE3 SKP1 CUL1 FRAT1 PPP2R5E MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling CRK ARF6 RAB4A RAB4B MET GAB1 GGA3 HGF CRKL IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA PPIA PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation SMAD2 SMAD4 GSC SMAD3 MIXL1 TRIM33 BMP4 POU5F1 SOX2 TBXT NANOG LEF1 TCF7 EOMES FOXH1 CTNNB1 TBPL2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot PLAT SERPINE1 SERPINB8 SERPINB6 S100A10 PLAU PLAUR SERPINE2 SERPINF2 SERPINB2 PLG ANXA2 HRG PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi ST3GAL4 TMED2 SEL1L RFNG MFNG B4GALT1 FURIN LFNG ST3GAL6 ST3GAL3 ATP2A3 RAB6A ATP2A2 ATP2A1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo YAP1 TJP2 WWC1 STK4 SAV1 WWTR1 STK3 MOB1B YWHAB LATS1 MOB1A LATS2 DVL2 AMOTL2 AMOTL1 YWHAE TJP1 NPHP4 CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA AREG EGF PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK2 CDK4 CCNE1 CDKN1B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) IDH3B CS ISCA2 IDH3A MDH2 ISCA1 ACO2 ACAT1 LYRM4 SUCLG2 KGD4 SUCLG1 CSKMT SDHC TRAP1 SDHD SDHA SDHB OGDH FXN NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH IDH2 SIRT3 DLST IDH3G DLD INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling STAT5A STAT5B UBE2D1 LYN STAT3 UBA52 JAK2 JAK1 STAT1 SOCS1 UBB CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins AQP1 GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 RAB11A PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 AVP GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A RAB11FIP2 MYO5B GNG10 AQP4 AQP2 GNG12 AQP3 GNG11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling NTRK1 CLTC AP2S1 CLTA AP2A1 AP2A2 SH3GL2 NGF AP2B1 AP2M1 DNAL4 DNM3 DNM1 DNM2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation MMP15 COL18A1 COL17A1 MMP19 COL15A1 COL16A1 TMPRSS6 COL13A1 COL14A1 FURIN COL12A1 COL19A1 ELANE COL26A1 COL25A1 COL23A1 ADAM10 ADAM9 PRSS2 MMP8 MMP9 COL9A1 MMP1 COL9A3 MMP2 COL9A2 ADAM17 PHYKPL CTSD MMP3 CTSB MMP20 CTSL MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation IKBKB TASL CHUK IRF5 SLC15A4 IKBKG TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling GNG13 ITGA5 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 SRC GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNAI3 GNAI1 GNAI2 GNG10 ITGB1 GNG12 GPER1 GNG11 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation TRAF2 RELA NFKB1 TRAF6 NFKB2 CHUK IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG IKBKB NFKBIA AGER MAVS RNF135 S100A12 MAP3K1 RIGI APP S100B SAA1 HMGB1 NFKBIB TRIM25 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE NPL NEU2 NEU3 NEU4 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA ST6GALNAC1 CMAS SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 NANP ST8SIA3 NANS GLB1 ST6GAL1 ST6GAL2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL PGM1 GYG1 PYGM PHKG1 PHKG2 GYG2 AKR1E2 AGL PHKA1 PHKB PHKA2 GAA CALM1 PYGB METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins ACE2 CMA1 CTSZ CTSD CPB2 CTSG CPA3 MME ANPEP ENPEP AGT CPB1 GZMH ATP6AP2 ACE CES1 REN REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 VCP TMPRSS2 CTSL HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation CREBBP RPTOR MLST8 HSP90AA1 HSPA8 EP300 CAMK2B CAMK2D HSPB8 HSP90AB1 CAMK2A MTOR DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A CRYAB AKT1S1 FKBP4 HSPA1B CAMK2G INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling STAT5A STAT5B STAT3 PIK3R2 PIK3R1 BRWD1 JAK3 JAK1 CISH TSLP IL2RG SOCS1 IRS1 IRS2 CRLF2 H3C8 SMARCA4 SOCS2 IL7 IL7R RAG2 RAG1 HGF PIK3R3 H3C15 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 FURIN HSPA8 CSNK2A1 HSP90AB1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RXRA CYCS HDAC3 NR1D1 TBL1X NCOA1 ESRRA ATF2 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 TWNK SSBP1 HCFC1 CALM1 PPARGC1A NCOA2 PPARGC1B NCOA6 SMARCD3 NRF1 GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HELZ2 CREBBP CHD9 ALAS1 MTERF1 GABPA MED1 SIRT5 TGS1 PPRC1 MEF2D PERM1 CAMK4 IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 PPARA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK STAT3 PIK3R2 PIK3R1 HDAC1 PLCG1 HDAC3 JAK3 SIN3A ALKAL2 ALKAL1 PRDM1 CD274 IL2RG PTPRZ1 IRS1 DNMT1 PIK3CB PTN MYCN MDK EP300 MYC PTPN6 HDAC2 ALK FRS2 HIF1A PIK3CA NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs NEIL3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MT-ND4L GFM1 GFM2 MRRF MT-CYB MTFMT MTRF1 TSFM MTRF1L MTIF2 MTIF3 MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation FCN3 FCN1 COLEC10 MBL2 MASP1 COLEC11 FCN2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism PAH ASRGL1 KYAT1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PCBD1 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia IVD TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host HBA2 HBB REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels ATP2A3 ATP2A2 ATP2A1 ATP2B4 SLC8A1 ATP2B3 SLC8A2 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors PARK7 PPARGC1A PIAS4 NCOA2 DDX5 NPM1 TRIM28 SIN3A NRIP1 HIPK2 DAXX ZNF131 UHRF2 NCOA1 DDX17 CASP8AP2 CTBP1 MBD1 SAFB TOPORS CREBBP MRTFA NCOR2 BMI1 PIAS3 ING2 SUMO3 SUMO2 EP300 RING1 UBE2I PIAS1 SUMO1 RNF2 CBX8 PHC2 PHC1 CBX4 PCGF2 CBX2 PHC3 ZNF350 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system UBC RPS27A TLR2 B2M UBA52 MRC1 UBB ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria E2F1 PMAIP1 TP53 TFDP1 TFDP2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B2 SLC26A2 SLC26A11 SLC26A1 PAPSS2 PAPSS1 SLC35B3 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2E1 CYP2F1 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2S1 CYP2D6 CYP2A7 CYP2A6 CYP2C19 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling TIAM1 LYN ARPC1B ARPC1A KALRN RHOA ROCK1 ROCK2 ARPC4 CFL1 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ARHGEF28 ACTG1 SDC2 ACTB CDC42 ITSN1 RASA1 YES1 PAK1 LIMK2 RAC1 HRAS LIMK1 FYN GRIN2B GRIN1 PTK2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PCNA AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA ELL CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XPA COPS7B COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 PPIE COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 ERCC5 COPS8 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GRIK5 GRIK3 GNG3 GRIK4 GRIK1 GRIK2 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD PLCB3 PLCB1 GNG10 DLG3 PLCB2 DLG4 CALM1 GNG12 GNG11 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LRP1 RETSAT APOA2 APOM APOA1 BCO2 APOA4 BCO1 HSPG2 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 RUNX3 ITGAL CBFB SPP1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS CYP19A1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis CAD DHODH UMPS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence CDKN2D CDKN2C CDKN2B UBA52 CDKN2A RB1 MAPK1 E2F1 E2F2 E2F3 CDK6 TFDP1 MAPK3 TFDP2 ETS1 CDK4 ETS2 UBB UBC SP1 TNRC6C ERF RPS27A MOV10 ID1 AGO3 AGO4 AGO1 MDM2 TNRC6A MDM4 TNRC6B TP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin MAOA ALDH2 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB14 RHOQ KIFAP3 RALGAPA2 RALGAPB RAB13 PRKAA2 KIF3A PRKAG1 PRKAG2 LNPEP PRKAG3 KIF3B PRKAB2 PRKAB1 YWHAB YWHAE C2CD5 EXOC8 EXOC7 AKT1 YWHAQ CALM1 YWHAG ASPSCR1 YWHAH EXOC4 YWHAZ EXOC3 SFN EXOC6 STX4 TBC1D1 EXOC5 SNAP23 TBC1D4 EXOC2 EXOC1 RALA RAB11A RAB4A MYO1C MYO5A VAMP2 AKT2 SLC2A4 RAB8A RAB10 RAC1 MYH9 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly GJB6 GJB5 GJB7 GJC1 GJC2 GJA3 GJA1 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJB2 GJD4 GJB1 GJD3 GJB4 GJB3 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF22 TGFBR3 GIPC1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling CXCL8 CD86 CD80 IL10RA PTAFR CXCL2 STAT3 LIF IL1RN CXCL1 FPR1 CCL3L3 IL1R2 CCR5 CCL5 IL12B IL12A CCL4 IL18 CCL3 JAK1 IL1A CCL2 IL1B CCL19 IL10 CCR2 IL10RB CSF2 CCR1 IL1R1 CSF3 CCL22 TYK2 CCL20 TNFRSF1B FCER2 CXCL10 TNF ICAM1 PTGS2 IL6 TIMP1 TNFRSF1A CSF1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 GP9 VWF GP1BA GP1BB TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct WFDC2 MECOM OSR1 FGF2 GATA3 HOXB4 ID4 BMP4 HOXA6 PAX8 LHX1 PLAC8 CTNNB1 NPNT PAX2 RET EMX2 PCDH19 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 MET GAB1 HGF PTPN11 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle SEL1L PRKCSH UBA52 RNF185 GANAB PDIA3 EDEM2 UBB UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN ITGA2 GXYLT2 CDH2 PXN SERPINE1 STT3B CDH1 SOX2 EDIL3 ZEB1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants FLT3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX12 PEX3 ACBD5 GDAP1 PEX13 PEX14 PXMP2 PXMP4 ABCD2 PEX11B ABCD3 PEX26 ABCD1 PEX2 ATAD1 PEX16 FIS1 PEX19 SLC25A17 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation B4GALT6 B4GALT4 B4GALT5 MGAT4A ST3GAL4 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 B4GALT2 B4GALT3 MGAT5 ST8SIA3 ST6GAL1 MGAT4C OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions TREM2 PLXNA2 ITGA1 SEMA3E SEMA4A CD72 SEMA5A SEMA4D PLXND1 PLXNC1 SEMA6A PLXNA4 SEMA6D PTPRC SEMA7A ITGB1 PLXNA1 TYROBP PLXNB3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry LY6E TIMD4 AP2A1 TYRO3 FURIN AP2A2 MERTK PIK3R1 UBA3 MAPRE3 EMC4 CD14 AP2M1 UBA1 HSPA5 CD33 HSPG2 CLDN1 CD209 SDC4 ATG7 SDC2 SDC3 AP2S1 AXL AGRN GPC1 AP2B1 UBA7 GPC3 HAVCR1 UBA6 GPC2 UBA5 MRC1 GPC5 GPC4 GPC6 RPSA PROS1 SDC1 CD300A GAS6 RNASEK RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 CDK2 LMNB1 MLH1 UBE2I FIGNL1 TEX12 TEX15 MSH4 MSH5 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B MND1 FIRRM REC8 BLM SYCP3 MRE11 BRCA1 BRCA2 STAG3 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 SPO11 H2BC12L H2BC21 SUN2 SUN1 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 SMC1A RAD50 SMC3 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 STAG1 H2BC11 STAG2 ATM RAD21 ATR H3C15 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS PTDSS2 PTDSS1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 CSNK1A1 PARP14 PARP8 UBA52 ST6GALNAC3 ST6GALNAC4 SRPK2 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD ITPR3 WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 PIK3CA VAV1 VAV2 IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 PLD4 V2-19 MAPK1 V1-11 PLD3 V1-16 V1-13 ELMO2 MAPK3 PLD2 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 PRKCD DOCK1 BRK1 LYN BTK CFL1 PLPP5 PLPP4 ACTB MYO5A YES1 HCK SYK PAK1 AHCYL1 FYN NCKAP1L WASF1 PRKCE PTK2 WASF2 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes IFI6 IKBKB IFI44L FKBP5 ARIH1 UBA7 HSPA5 RIGI CHUK ATF6 ISG15 IFIH1 UBE2L6 TRIM25 HERC5 IFI27 EIF2AK3 IKBKG RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors INSL3 INSL5 RXFP4 RXFP1 RLN2 RXFP2 RLN3 RXFP3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PTK6 CDKN1A CCND1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis SLC2A1 B4GALT1 LALBA SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine AMDHD2 GFPT2 GFPT1 PGM3 NAGK GNPNAT1 UAP1 RENBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) MBD4 PCNA SMUG1 PARP1 NEIL2 NEIL1 MPG PNKP LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 OGG1 RFC2 RFC1 PARP2 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLB POLE2 POLE3 PARG NTHL1 APEX1 TDG ADPRS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling HRAS SOS1 HBEGF SHC1 TGFA AREG EGF EGFR NRAS EREG BTC EPGN PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation JUN XIAP RNF146 USP7 MBD3 TNKS GATAD2B GATAD2A PREX2 PTEN CHD4 SNAI2 RCOR1 TRIM27 WWP2 EED NEDD4 MKRN1 FRK HDAC5 USP13 MTA2 HDAC7 RBBP4 MTA1 REST MTA3 RBBP7 TNKS2 PML AKT2 OTUD3 HDAC1 HDAC3 KDM1A MAPK1 MAPK3 ATF2 EGR1 RPTOR TNRC6C MOV10 MLST8 SLC38A9 CHD3 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 HDAC2 TNRC6A TNRC6B MTOR RNF2 PSMD8 RRAGA PSMD6 RRAGC SUZ12 CBX8 PSMD7 PHC2 RHEB RRAGB PHC1 PSMD2 RRAGD NR2E1 CBX4 PSMD3 LAMTOR2 AKT1 CBX2 LAMTOR1 PSMD1 PHC3 LAMTOR4 LAMTOR3 LAMTOR5 MECOM PSMA5 STUB1 PSMA6 PSMA3 PSMA4 ATN1 PSMA1 SALL4 MAF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 SNAI1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 PPARG AKT3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN NOS3 WASL DNM2 CAV1 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes CREBBP MAFK NFE2L2 ABCC3 EP300 ABCF2 ABCC1 ABCG2 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA ASCC2 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBE2D1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 UBB RPS17 RPS15A RPS16 RPS19 UBC RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 ZNF598 RPS24 RPS27 RPS23 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 IPPK ITPK1 IP6K1 NUDT3 NUDT4 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function SOX10 CTNNB1 JUP CDH19 CTNND1 ZC3H12A CTNNA1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ARAP1 UBC PTK6 RPS27A DOK1 CBL AKT1 UBA52 UBB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBIN HSP90AA1 ERBB2 CDC37 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH KGD4 DLST DLD PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing JUN H2BC9 H2AZ2 H4C9 SEL1L H2BC8 H2BC5 H2BC3 FURIN H2BC1 H2AC20 CCND1 ATP2A3 ATP2A2 MAMLD1 ATP2A1 RBPJ TMED2 TNRC6C RFNG MOV10 MFNG B4GALT1 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 ELANE E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 ST3GAL4 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A LFNG EP300 ST3GAL6 H3-3B H3C8 ST3GAL3 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins APBB1IP TLN1 CRK FN1 SRC BCAR1 RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 NTF4 NTRK2 BDNF PLCG1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 GNAS RAB11A AVP PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 CLOCK NPAS2 HELZ2 RAI1 CREBBP CHD9 NCOR1 MEF2C TBL1XR1 EP300 MED1 TGS1 MEF2D RORC RORA RORB SIRT1 PPARA CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNG13 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ABL1 ADCY1 SPP1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PRKACG PRKACA PRKACB STAT1 PECAM1 GNG3 GNG2 NFKBIA GNG5 GNG4 GNG7 GNA11 GNG8 GJA1 NOS3 PRR5 P2RX7 TRPV4 GNAS PKN2 CACNG7 CAPNS1 CAPNS2 CAPN2 RAMP2 PPP2R1B PPP2R1A CALCRL PIK3CB ADM PRKAR1B PRKAR2B PRKAR1A PRKAR2A PDPK1 CACNB2 PIK3CA P2RY2 ITGB3 ITGB1 MAPKAP1 ITGAV ITGA5 CACNA2D1 PIK3R2 NFKB1 PANX1 HSPG2 CTNNB1 CHUK PTPN1 CACNB1 CACNB3 IKBKB PPP2CA MLST8 MTOR IKBKE AKT1 CALM1 FLT4 KDR IKBKG ANXA2 TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD FYN CACNA1H GNG10 PTK2 GNG12 MMP14 GNG11 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 FZR1 SKP2 CCNE2 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 POLD3 POLD4 POLD1 POLE POLD2 RFC1 POLE4 POLE2 POLE3 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes AIM2 BCL2 RELA BCL2L1 NFKB1 HSP90AB1 NLRC4 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 NLRP1 PYCARD NLRP3 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription CREBBP RBPJ MAML2 FABP7 MAML1 KAT2B HEY1 KAT2A HES1 SNW1 EP300 WWC1 HEY2 DLGAP5 HES5 PTCRA PLXND1 PBX1 HEYL MAMLD1 MAML3 STAT1 NOTCH3 NOTCH1 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing ABHD17C FNTA ABHD17B BCL2L1 ABHD17A RCE1 NRAS PDE6D ICMT HRAS FNTB LYPLA1 PRKCQ ARL2 PRKG2 GOLGA7 KRAS USP17L2 CALM1 ZDHHC9 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism SLC26A2 SLC26A11 SLC26A1 PRKACG SLC2A1 PRKACA PRKACB G6PD B4GALT6 B4GALT5 FUT2 FUT1 TKFC B3GALT4 GALM PCK2 SLC37A1 G6PC2 G6PC3 FBP1 FBP2 SLC35B3 B4GAT1 LALBA SLC35B2 XYLT2 SLC35D2 XYLT1 B4GALNT2 B3GALT2 B3GALT1 FAM20B FUT4 FUT6 FUT5 FUT7 FUT9 B3GALT5 CHPF GALK1 PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 GALE CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 GCKR GCK PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 B3GAT3 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU B4GALT1 NDST4 TKT GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE NUP214 UBA52 MAN2B2 MAN2C1 UBB TALDO1 UBC ABCC5 RPS27A GAPDHS PGD PC GBE1 PYGM CEMIP STAB2 GYS2 LYVE1 PHKG1 HAS1 PHKG2 HYAL2 GYG2 HAS3 EPM2A GNS CHP1 AKR1E2 PHKA1 HAS2 SPAM1 PHKB PHKA2 PPP1R3C NHLRC1 GALT PYGB PYGL B3GALT6 SLC37A4 B4GALT7 ABO IDUA NCAN HEXB HEXA BGN AGL GLB1L3 DCN GLB1L2 BCAN NUP205 POM121 VCAN NUP107 GLB1L HYAL1 NUP188 GLB1 AAAS HYAL3 HYAL4 NUP160 POM121C AKR1B1 IDS CSPG5 NUP42 NUP85 CSPG4 TPR GUSB ARSB NUP62 GYG1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 GYS1 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RHCE PPP2R1B RHD PPP2R1A PGM2 PGM1 FUT3 PPP2R5D DERA G6PC1 B3GNT3 CHST14 DCXR AKR1A1 HSPG2 SORD CRYL1 XYLB MANBA GAA PCK1 ACAN LUM CD44 PPP2CA PPP2CB AGRN FMOD HK1 CALM1 GPI ADPGK ENO1 ENO2 ENO3 HK2 ENO4 HK3 TPI1 PGAM1 PGAM2 MAN2B1 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 ST6GALNAC6 PGK2 PFKL GNPDA1 GNPDA2 PFKM DSEL PFKP DSE UST CHST15 GLYCTK ST3GAL4 KHK SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 ST3GAL2 HMMR ST3GAL3 SLC9A1 UGP2 ALDH1A1 PRPS2 PRPS1 RPEL1 RPE CTSL SHPK PGLS PRPS1L1 RBKS SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 NUP107 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG DNMT1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B CHAT PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC18A3 SLC5A7 TSPOAP1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR2 GNPAT DHRS7B AGPS AWAT1 AWAT2 FAR1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport RHBG RHCG RHAG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases GUCY2C NHERF4 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle ARHGAP26 MPP7 VANGL1 ARHGAP32 ARHGEF7 PIK3R2 PIK3R1 RHOJ ARL13B CDC42 CPNE8 STEAP3 WIPF2 FMNL3 FNBP1L GJA1 FNBP1 SCRIB LAMTOR1 TFRC IQGAP3 SNAP23 ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 SYDE1 OPHN1 GIT1 TMPO DOCK8 WASL OCRL DEPDC1B CDC42EP1 VAMP3 RAB7A TRIO WAS NIPSNAP2 SLC1A5 ARHGAP21 PREX1 STOM PAK1 PAK3 CDC42BPB CDC42BPA PAK2 PAK4 DIAPH3 GIT2 CAV1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 POFUT2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 PSIP1 HMGA1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 RAC1 RAP1B RAPGEF1 RAP1A CRK MET GAB1 DOCK7 HGF CRKL DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events PPP2CA PPP2CB PPP1R1B PPP2R5D CDK5 PRKAR1B PRKAR2B PPP3CC PRKAR1A PDE4A PPP1CA PRKAR2A PDE4D PDE4C PPP3CA PRKACG PPP3CB PRKACA PRKACB PPP3R1 CALM1 PPP2R1B PPP2R1A SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling PRKCA SOS1 HBEGF SHC1 EGF ERBB2 EGFR NRAS NRG1 HRAS PRKCE EREG NRG3 NRG4 PTPN12 NRG2 BTC PRKCD MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer CDKN1A RPS6KB2 CDKN1B RICTOR CHUK FOXO4 BAD MLST8 FOXO6 FOXO1 AKT2 TSC2 MDM2 NR4A1 MTOR PRR5 PDPK1 FOXO3 AKT1S1 GSK3A AKT1 CASP9 GSK3B MAPKAP1 AKT3 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones RUVBL1 KANSL1 KANSL2 KANSL3 H2AC1 EP400 KAT7 ATXN7 SUPT20H ATXN7L3 TADA3 ING4 ING3 PAX3 OGT SUPT3H TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 WDR5 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2BC18 DMAP1 MRGBP TAF9 TADA1 VPS72 MSL2 MSL3 MSL1 TAF12 RBBP7 H2AC19 H2BC26 H2AC14 USP22 H2BC21 TAF10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 H2BC9 BRPF1 H4C9 BRPF3 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 ATF2 PHF20 ING5 SAP130 KAT8 TRRAP H2AC17 BRD1 H2AC12 KAT14 MEAF6 ZZZ3 HCFC1 TADA2A SGF29 NCOA2 TADA2B H2AC25 EPC1 H2AC21 KAT5 ACTB CLOCK ACTL6A CREBBP YEATS4 MBIP DR1 KAT2B KAT2A YEATS2 KAT6A MCRS1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation INS GRB10 IRS1 INSR IRS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells HRAS RASGRP3 NRAS RASGRP1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events CXCL6 CXCL9 CXCL8 TAS2R10 CXCL13 TAS2R13 CXCL3 TAS2R14 CXCL2 TAS2R16 ADCY9 CXCL5 CX3CL1 GNAL ADCY4 CXCL16 ADCY3 CCR9 ADCY2 CCR8 ADCY1 CCR7 ADCY8 KNG1 CCR4 ADCY7 CCR3 ADCY6 CCL13 ADCY5 CX3CR1 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCR6 CCL5 PPBP CXCR3 CCL4 RGSL1 OPN3 CCL1 RRH TAS2R40 CCL19 TAS2R41 CCR2 RGR TAS2R43 CCL16 OPN5 PLA2G4A TAS2R46 CCR10 CCL25 CCR1 CCL21 FPR2 CCL20 CXCL10 PDE1B CXCL11 RXFP4 PDE1A CXCL12 ITPR1 GPR17 ITPR2 ACKR3 TAS2R30 ITPR3 TAS2R31 CCL28 RXFP3 CCL27 PSAP TAS2R38 NMS PDYN NMU AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 SSTR3 GPR37 ANXA1 GPR31 PLCB4 GNAS GPR55 MTNR1A TAS2R50 MTNR1B MCHR1 RLN3 LPAR1 LPAR2 LPAR3 LPAR5 PPP3CC MT-RNR2 CHRM2 INSL5 PENK S1PR3 S1PR2 APLN GPR37L1 CHRM4 S1PR5 TAS2R19 S1PR4 PMCH TAS2R42 RGS4 TAS2R45 RGS5 PPY RGS3 RGS1 TAS2R60 CASR OXGR1 GAL MCHR2 NPB NPW NMUR2 NMUR1 NPY2R NPY1R APLNR PRKAR1B SUCNR1 BDKRB2 PRKAR2B HCAR2 BDKRB1 PRKAR1A HCAR3 PRKAR2A PRKX HCAR1 PPP3CA PPP3CB GNAT2 PYY RGS18 TAS2R9 RGS17 PLCB3 RGS19 PLCB1 HEBP1 RGS13 PLCB2 RGS16 P2RY12 GRM3 PPP3R1 P2RY13 P2RY14 GRM2 GRM7 P2RY4 RGS21 ADORA3 GRM6 ADORA1 GPER1 GRM8 NPY5R SSTR1 SSTR2 HRH4 SSTR4 SSTR5 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 HTR1E CNR2 CNR1 HTR1F OPRD1 HTR1D HTR1B ADRA2C HTR5A ADRA2B C5AR1 ADRA2A C5 TAS2R7 PTGDR2 PTGER3 TAS2R8 AGT GRM4 TAS2R1 TAS2R3 PRKCD TAS2R5 PRKCA TAS2R4 PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG GNG10 NBEA GNG12 GNG11 GNG13 GNB2 GNAQ C3 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 OPN1LW GNAZ GNA14 GNG3 CDK5 GNA15 OXER1 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 OPN1MW RGS11 RHO GNAT1 PPP2R1B PPP2R1A PPP2R5D NPY MAPK1 GNAT3 PPP2CA PPP2CB PPP1R1B CXCR1 CCL4L2 CXCR2 RGS8 CAMK2B PCP2 CAMK2D SRC GPSM1 GPSM2 CAMK2A PDE4A GPSM3 PDE4D PDE4C GNAI3 RGS14 RGS20 GNAI1 RGS22 RGS10 GNAI2 RGS12 OPRM1 SST CALM1 CAMK2G OPN1SW GABBR2 GABBR1 OPRK1 POMC CXCL1 PPP1CA TAS2R20 CAMK4 APP SAA1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 BDH2 BDH1 HMGCL HMGCS2 HMGCLL1 AACS ACAT1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 LYN PLCG2 PLCG1 EPO EPOR IRS2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain F8 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MTA2 ERCC6 RBBP4 MTA1 MBD3 MTA3 TTF1 RBBP7 H2AX EHMT2 GATAD2B GATAD2A H2AB1 H2AC19 H2BC26 H2AC14 CHD3 H2BC12L H2BC21 CBX3 H3-3B H3C8 HDAC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CHD4 H3C15 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD HNMT MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 HSPE1 HSPD1 ESR1 LONP1 CAT NRF1 DEFA5 HSF1 DNAJA1 HSPA1A SOD2 SIRT3 FOXO3 AKT1 HSPA9 HSPA1B HTRA2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH ADHFE1 D2HGDH NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown NUP85 PRKCA TPR NUP62 BANF1 PLK1 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 VRK1 CDK1 NUP153 LEMD2 NUP93 NUP50 NUP35 EMD NUP54 LMNB1 NUP37 LEMD3 CNEP1R1 LPIN1 LPIN2 LPIN3 PRKCB NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 S PHASE%REACTOME%R-HSA-69242.5 S Phase ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 CDCA5 RB1 CDKN1B FZR1 E2F1 RBBP4 SKP2 CABLES1 ESCO1 ESCO2 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 CKS1B MAX POLD3 POLD4 POLD1 POLE POLD2 RFC1 AKT2 PDS5B SMC1A SMC3 PDS5A WAPL POLE4 STAG1 STAG2 RAD21 POLE2 POLE3 PTK6 CDKN1A CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B RBL2 ANAPC15 ANAPC16 ANAPC7 CCNH UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones ATP6V0D1 SRPRB TPP1 PREB CXXC1 HDGF PPP2R5B KDELR3 SHC1 ADD1 DCTN1 HSPA5 SEC31A ERN1 EXTL2 PLA2G4B EXTL3 HYOU1 GSK3A ACADVL PDIA6 DNAJB11 SERP1 WFS1 TLN1 DNAJC3 CUL7 FKBP14 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 CTDSP2 SRPRA MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 TSFM MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 GFM1 MRPS17 MRPS15 MRPS16 MRPS14 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PHF20 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 MDM2 PSMC5 MDM4 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 GNE CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) FZD2 GNG13 FZD5 FZD7 WNT5A FZD4 GNB2 WNT16 FZD6 GNB1 WNT1 FZD1 GNB4 FZD8 GNB3 PTHLH GNB5 GNGT1 GNGT2 GIP IHH SMO PTCH1 GNG3 FZD10 GNG2 GNG5 GNG4 GNG7 CRHBP ADCYAP1 GNG8 ADCYAP1R1 CD55 WNT10A FZD9 UCN PTH1R UCN3 UCN2 PTH2R WNT7B GNAS CRH WNT7A GCGR GCG PTH2 WNT3A ADGRE5 ADGRE3 WNT9A GLP1R SHH VIPR1 DHH VIPR2 CRHR1 SCT WNT3 RAMP2 GIPR CALCA GHRHR GLP2R RAMP3 WNT8A CALCB WNT8B SCTR CALCR GHRH CALCRL VIP ADM2 ADM IAPP RAMP1 PTH WNT10B WNT9B WNT6 WNT4 WNT2 PTCH2 WNT2B ADGRE1 GNG10 ADGRE2 WNT11 GNG12 FZD3 GNG11 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic STX5 BET1L GOLIM4 RAB33B RAB41 GOLGA5 ARF1 NAPA NAPB COG8 COG7 COG6 STX16 NSF COG5 MAN2A1 COG4 GOSR1 COG3 NAPG COG2 COG1 CYTH3 RAB30 CYTH2 RAB36 CYTH4 CUX1 MAN1C1 SNAP29 STX6 MAN2A2 VTI1A CYTH1 RIC1 RAB39A RGP1 ALPP TRIP11 GOSR2 MAN1A2 VPS45 YKT6 MAN1A1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation B3GNT5 B4GALT6 B4GALT5 MMRN1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ADAMTS13 GALNT10 GALNT9 POMT2 GALNT8 B3GALNT2 B3GNT9 QTGAL SLC35A4 B3GNT8 FKRP CRPPA B3GNT6 GALNT1 POMT1 CHST4 POMGNT2 GCNT1 POMGNT1 GCNT3 B4GAT1 GCNT4 MGAT5B GCNT7 CHST10 GALNT7 GALNT6 POMK DAG1 GALNT5 RXYLT1 GALNT4 LARGE1 A4GNT LARGE2 GALNTL5 GALNTL6 FKTN GALNT2 POFUT2 B3GNT7 B3GNT4 B3GNT2 POFUT4 POFUT3 EMID1 MMRN2 MUC13 B3GNT3 GALNT12 SEMA5A SPON2 SEMA5B SPON1 ST6GALNAC2 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 ST6GAL1 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ST6GALNAC3 ADAMTS14 ST6GALNAC4 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification NR5A1 PCNA SEL1L RELA CP NPM1 RNF185 NR3C1 SP100 DERL1 DERL2 RNF5 RAB9A RAB9B OS9 VDR ARF4 IL6 SENP5 SENP2 NOP58 CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 SHISA5 PDIA6 MXRA8 SPARCL1 AURKA SCG2 GBF1 TGOLN2 STC2 PENK RAB11A IGFBP7 NDUFAB1 AMELX POMT2 WFS1 B3GALNT2 AMBN ZNF131 TMEM132A SLC35A4 FUCA2 UHRF2 FKRP HRC CRPPA DDX17 CASP8AP2 POMT1 MELTF MBD1 SERPINA10 POMGNT2 MIA3 SAFB POMGNT1 B4GAT1 MSLN TOPORS PRSS23 MGAT5B CHRDL1 CHST10 BMP15 POMK DAG1 RXYLT1 LARGE1 MEPE LARGE2 DNAJC3 B4GALNT2 RCN1 FKTN PIAS3 VGF ENAM AMTN VWA1 FAM20C FAM20A DDB1 MFGE8 UBE2V2 ITIH2 COPS7B SERPINC1 XPC AFP COPS7A FSTL1 FSTL3 CST3 APOL1 CUL4A TOP2B TOP1 SERPIND1 COPS3 GOLM1 POFUT2 COPS6 COPS5 NUCB1 NOTUM UBE2N POFUT4 COPS8 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGO DCTN6 PIGN DCTN5 PIGP DCTN1 PIGZ DCTN4 PIGW NR3C2 PIGV PIGY PIGX LRRC49 PIGC PIGB CAPZA3 PIGA PIGM PIGL CAPZA2 PIGG PIGF ACTR10 PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 SQSTM1 TTLL1 CHM TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H TFAP2B ING2 SPRN SPACA4 TFAP2C NICN1 UBE2I MDGA2 SUMO1 RECK MDGA1 NRN1 ART3 UBE2D2 ART4 UBE2D3 NTNG1 NTNG2 HIF3A RAB22A CD59 CD52 CD55 ELOB PRND ELOC RBX1 CNTN5 ALPL EPAS1 CNTN3 CNTN4 CUL2 ALPG HIF1A TEX101 VHL RAB40A RAB40B ZNF350 RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 ACTB PTP4A2 DCAF7 RTN4RL1 TTL TUBB6 RAB20 TUBB3 RAB25 TUBB1 RAB26 FBXO4 SVBP RAB23 FBXO6 RAB29 RAB15 RAB19 RAB17 FBXW4 TTLL10 FBXW5 NFU1 FBXW10 TTLL13 MEN1 TTLL11 FBXW7 TTLL12 FBXW9 IGFBP1 UMOD LIAS OTOA FBXW2 RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C TP53 LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FBXL3 EIF5A FBXL5 DHPS FN3KRP EIF5A2 TUBA1C FN3K TUBA1B ICMT DOHH TUBA1A TUBB2B FUCA1 TUBB2A USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 WDR5 RAB3D AAAS NUP160 POM121C NUP42 RAB44 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB31 NUP155 RAB37 NUP133 NUP210 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 HDAC7 NUP54 RAB6A TRAPPC1 RBBP5 RAB4B NUP37 RBBP7 CDC20 FCGR3B MRTFA PML DYNC1LI1 DYNC1LI2 RAB24 CDCA8 RAB10 RAB18 COMMD9 DYNLL1 PARP1 BST1 RANGAP1 VNN1 DYNLL2 CTSZ RHOA INCENP BIRC5 CTSC PRMT3 DYNC1I2 COMMD3 AURKB KCTD6 DYNC1I1 DYNC1H1 NR4A2 THRB TFG COPB1 NR2C1 THBS1 GOLGB1 NFKB2 FGA PLAUR FGG CAND1 ANK1 F7 F9 PROC F10 GGCX SKP1 CCNA2 PROS1 PROZ CCNA1 F2 GAS6 CUL1 DBT PCSK9 APOA2 APOA1 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB LAMB2 FN1 LAMB1 LAMC1 BTRC ADAMTS13 MTA1 RPS2 RPS6 EEF1A1 B4GALT2 B4GALT3 LRR1 CCNF B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B CDC34 PSME1 UBE2J2 SEC31A FBXL8 CALR FBXL4 LRRC41 GAN RRAGA SOCS2 SOCS6 KLHL2 KLHL3 IKBKE UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 CETN2 ACTR1A FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 CSNK1D FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 DCTN2 CUL7 CUL5 UBA6 DCTN3 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F YKT6 UBE2H KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W JMJD6 UBA3 RIOX2 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A ANO8 RNF168 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ANKRD28 ASPH ASB9 ASB6 ASB7 PPP6C PPP6R3 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 TP53BP1 GALNT1 ARFGAP3 ARFGAP2 COP1 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SMC1A SEC31B SMC3 TRAPPC2 SEC16B TRAPPC3 TPST2 KTN1 SEC16A STAG1 TPST1 TRAPPC5 TRAPPC9 STAG2 RAD21 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 TDG CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RAD52 RPL8 DCAF13 MATN3 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 HDAC4 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 AMER1 RPL27A AXIN1 APC CDC73 NCOA2 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PNPLA2 CTBP1 RWDD3 UBA2 DNMT1 SAE1 CREBBP AREG NFE2L2 DNMT3B TGFA DNMT3A EIF2AK2 STS MGAT3 ETF1 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG APOB ARSD UBE2L3 USO1 TUBB8 RAB2A TUBB8B SPTAN1 RAB1A RAB1B HGS RAB5A TOP2A GORASP1 UBE2T OTULIN FDX1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 FUT8 MITF GANAB ADAM10 MAN2A1 MGAT5 MGAT1 FBXL18 FBXL7 MGAT2 OST4 EDEM2 ARF3 MOGS DDOST SDC2 MGAT4C TMEM258 DAD1 OSTC MGAT4A TMED2 CANX MGAT4B STT3A STT3B MAN1B1 GPC3 TRRAP CCP110 KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR DCAF8 RNF128 DCAF5 VDAC3 DCAF4 VDAC2 PIAS4 DCAF6 VDAC1 WSB2 CFTR GATA3 OBSL1 BRCC3 DCUN1D5 SNX3 DCUN1D3 RHOT1 DCUN1D4 RCE1 DCUN1D1 DCUN1D2 ZRANB1 COMMD8 SIAH2 INO80 PUM2 ARF1 NPLOC4 STAM DDA1 TADA2B CYLD ANKRD9 H2AC25 UBXN7 COMMD2 H2AC21 COMMD1 BAP1 COMMD6 WDR48 OTUD7A COMMD7 OTUD7B COMMD4 BABAM1 COMMD5 RAB4A SPSB3 IFIH1 CCDC8 BABAM2 CISH UCHL1 TRIM4 CUL9 UIMC1 DPP3 UFD1 UBD IKBKG NAE1 SOCS5 TOMM70 RIPK2 WDTC1 ACTL6A CCDC22 JOSD2 COMMD10 TULP4 UCHL3 JOSD1 DCAF16 DCAF17 UCHL5 DDB2 FEM1C KAT2B DCAF10 KAT2A DCAF11 PTRH2 FEM1A FEM1B PRKN CAPZA1 WDR20 NEURL2 PSME2 NEDD8 ERCC8 USP17L21 USP17L20 GOSR2 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 USP17L12 ARFGAP1 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 PREB OTUD5 TOMM20 YY1 KDELR3 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS RWDD1 JMJD4 ADRB2 KDM8 FOXO4 VCPIP1 JMJD7 ATXN3 RIOX1 ATXN7 OGFOD1 DRG1 NLRP3 DRG2 RIPK1 RCCD1 SUDS3 CLSPN ZC3H15 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 STX5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 USP26 CAPZB USP20 USP21 RAB32 USP22 TAF10 RAB35 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 SCFD1 SPTBN1 RAB39B PARK7 MUC13 RAB8B INS RAB33A RAB7B FGF23 RAB21 CHML RAB11B RAB12 RAB13 ALPI GRIA1 HNRNPK CKAP4 SENP1 CALM1 UBE2C UBE2E1 UBE2D1 UBE2S CDK1 DLAT BLM PIGS BRCA1 PIGU PGAP1 PIGT WRN GPAA1 PIGK BARD1 CDH2 METTL21A KIN FBXW11 METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT RPA1 EEF1AKMT2 EEF1AKMT1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 DDX5 RAB41 KNG1 COG8 COG7 COG6 COG5 COG4 RAB27B COG3 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG MAN1A2 F5 F8 TMED3 MMRN1 MAN1A1 TMED7 TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B U2AF2 GALNT11 ARF5 GALNT14 NAPA GALNT13 NAPB GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GOSR1 NAPG GALNT8 GOLGA2 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 BPIFB2 GCNT1 GCNT3 GCNT4 GCNT7 MAN1C1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNT2 GALNTL6 ARCN1 COPG2 COPG1 LTBP1 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A COL7A1 MDC1 SPTB B4GALT1 DTL MYC ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 PSMD3 PSMD1 SPTBN2 NUP214 PSMD9 PSMD4 PSMA5 PSMD5 PPARGC1A PSMA6 PSMA3 PAAF1 PSME3 PSMA4 PSME4 PSMA1 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 UBA52 PSMG3 PSMG4 PSMD12 PSMG1 PSMD11 PSMG2 PSMD14 PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FOXL2 PSMC2 HIC1 SP3 PPARG PPARA LY6E PEX10 SRD5A3 PEX12 C3 PEX13 PEX14 FURIN BGLAP SPP1 IL33 RNF20 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC HLA-A RORA DLST VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT H2AC19 H2BC26 H2AC14 H2BC21 EP300 SOCS3 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RARA ETFB RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FBXO32 H2BC1 H2AC20 KDM1B NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 RABGGTB RABGGTA GALNT12 DPAGT1 SEMA5A ST6GALNAC1 SPON2 SEMA5B CMAS ST6GALNAC2 SPON1 THSD7B MPI ADAMTS4 HK1 ADAMTSL1 GMPPB NANP ADAMTS5 C1GALT1C1 FPGT ADAMTS2 GMPPA PGM3 ADAMTS3 ADAMTSL5 GNPNAT1 ADAMTSL4 GFUS NANS ADAMTS1 NUDT14 ADAMTSL3 ALG8 ADAMTSL2 ST6GAL1 MUC12 THSD7A ST6GAL2 ALG9 MUC15 ALG6 ADAMTS8 ALG5 ADAMTS9 ADAMTS6 SLC35C1 ADAMTS7 ALG14 ALG2 SBSPON ALG3 MUCL1 MUC3A ALG13 MUC5AC ALG12 MUC3B ALG11 ADAMTS20 ALG1 B3GLCT ALG10 CFP RENBP TRIM28 DHDDS THBS2 ADAMTS12 DPM1 THSD1 DPM2 THSD4 DPM3 ADAMTS10 RFT1 ADAMTS16 MVD ADAMTS15 ST6GALNAC3 ADAMTS14 ALG10B ST6GALNAC4 MUC1 ST6GALNAC5 MUC2 ADAMTS19 ST6GALNAC6 ADAMTS18 GNE ADAMTS17 UAP1 NPL MUC7 FUOM MUC4 NEU2 MUC6 NEU3 MUC16 NEU4 GALNT3 MUC17 DHRSX C1GALT1 GMDS AMDHD2 MUC19 NEU1 SSPOP MUC5B ST3GAL4 ST8SIA4 MUC20 MUC21 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 DPH1 ST3GAL2 DPH2 FBXL21P ST3GAL3 DPH3 MPDU1 DPH5 CTSA DNAJC24 DPH6 NUS1 SLC35A1 DPH7 PMM1 EEF2 ST8SIA1 UBXN1 ST8SIA2 NGLY1 GFPT2 RNF139 PMM2 MLEC ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor BAX NTRK3 NELFB DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing NTHL1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 FUT2 FUT1 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 ABO FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 RHCE RHD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence LIG1 BRCA1 TERT MCM5 MCM2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR CRLF1 TYK2 IL6ST LIF IL11 OSM OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA CTF1 CLCF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways TAS2R10 SEL1L TAS2R13 TAS2R14 TAS2R16 AVPR1B TAS2R40 AVPR2 TAS2R41 TAS2R43 AVPR1A TAS2R46 DERL2 ERLEC1 OS9 TAS2R30 TAS2R31 TAS2R38 TAS2R39 SSTR3 TAS2R50 MCHR1 PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 DNAJB1 GNA13 FGD3 PTGES3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 FKBP4 NGFR ARHGEF35 ARHGEF37 SOCS1 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 CYP26A1 MYD88 CYP26B1 CYP26C1 WWOX TAS2R7 TAS2R8 UBE2D2 UBE2D3 RBX1 EPAS1 HIF1A GRM4 VHL TAS2R1 TAS2R3 TAS2R5 TAS2R4 FES PIP5K1C POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 ACTB TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 CSNK2A1 CSNK2A2 CSNK2B TP53 ARL2 GNG10 CHD8 CBY1 GNG12 SOX3 GNG11 SOX17 GNG13 SRY CCT6A GNB2 SOX6 GNAQ SOX7 GNB1 SOX4 BCL9L CTNNBIP1 GNB4 SOX13 GNB3 PYGO1 BCL9 GNB5 PYGO2 GNGT1 ICMT TUBA1B GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 NUP107 AAAS NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 HECW1 ERCC6L ZWILCH KLHL12 BUB1B WNT3 ACTG1 CCDC88C CDC20 DACT1 WNT8A PPP1CC WNT8B PPP2R1B PPP2R1A CXXC4 KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B CHUK MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 MTMR4 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE DGKG CENPF DGKE DAGLA FMNL1 DGKD FMNL2 CENPH DGKB CENPI DGKA TAOK1 ABHD6 CENPK ABHD12 CENPL PRKCH CENPM DGKZ CENPN DGKQ DAGLB B9D2 CENPO DGKK CENPP DGKI CENPQ DGKH SPC24 SPC25 MAD2L1 DUSP8 CENPS DUSP9 FLT1 FLT4 MRAS KDR VEGFB PORCN VEGFC VEGFD PGF NF1 VEGFA DUSP10 ESRP1 GNA12 SHOC2 SPRED3 SPRED2 SPRED1 CCNT1 CD274 IL2RG NELFB KANK1 STRN MAP2K5 NCBP1 NRP2 NCBP2 CDH5 CDK9 ADH1C CRABP2 ADH1A LFNG CRABP1 JAG1 SDR16C5 ADH4 RDH11 RDH10 RDH16 WNT9B RDH14 RDH13 DLL1 AKR1C3 DHRS3 WNT4 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 SKP1 ALDH8A1 FGFRL1 CUL1 FLRT2 FLRT1 EVC2 IQCE EFCAB7 EVC BOC GAS1 NTRK3 DRC4 PMEPA1 BAMBI NTF3 CDON STRAP WWC1 NEURL1B DLGAP5 HES5 PTCRA RASGRP2 MIB2 RASGRP1 PBX1 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 TACC3 RAF1 PRKACA PRKACB RAPGEF3 RAPGEF4 CYSLTR1 TRPC7 TRPC6 PLCG2 TRPC3 RCOR1 LAMA5 LAMA2 SH3KBP1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 CHRM2 JAK3 CHRM3 CHRM1 CHRM4 CHRM5 HNRNPA1 LIMK2 RPS6 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GPNMB LRRK2 PTK6 RACK1 HBEGF TRAF1 HSP90AB1 TWF1 OPRD1 MSI2 RHOBTB2 ACTN1 TMOD3 LYPLA1 DDX39B RBCK1 PHIP FSHB INHBB INHBA INHA PRKAA1 PRKAA2 PTPRK EPS15L1 CAB39 EPN1 CAB39L PRKAG1 SPRY1 PRKAG2 PTPN3 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR LRRC41 FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 KBTBD7 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 FST ARHGDIB RAC3 FOXH1 ACVR1B EMD LBR ACVR2B GIT1 ACVR2A DRAP1 TMPO SWAP70 ACVR1C ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 RNF41 GARRE1 AMIGO2 NOXO1 CUL5 ARHGAP17 WDR83 SLC1A5 SYNGAP1 ARHGAP15 PAQR3 ARHGAP21 RGL3 LMAN1 RGL2 PAK1 PEA15 PGRMC2 DUSP5 RACGAP1 DUSP2 SLITRK3 DUSP1 NHS ABL2 IL17RD RAPGEF2 SLITRK5 DAB2IP NCKAP1L SEPTIN7 WASF1 CDC14B PAK2 RAG2 YKT6 RAG1 WASF2 PAK4 RASAL1 IL32 RASAL3 GIT2 RASGRP4 CAV1 RASGEF1A ETV4 MCAM RASA3 ERBIN RASA4 ARHGAP26 RASA2 BAIAP2 MPP7 ABHD17C VANGL1 IGF2BP1 MAPK6 ARHGAP32 MAPK4 ABI2 TAOK3 ANGPT1 NOXA1 ABHD17B ABHD17A ABI1 TEK NOX3 ESYT1 FERMT2 NOX1 TGFB1 UBE2M TGFBR1 TGFBR2 LMNB1 CPNE8 OXER1 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG TAX1BP1 FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 STMN1 ARHGAP33 RBFOX2 ARHGAP31 PDGFD DNMBP SHB ARHGAP30 MAP3K11 FGFBP3 FGFBP1 CDC42SE2 FGFBP2 DOCK6 ARHGAP9 ARF6 ARHGAP11B ALKAL2 ALKAL1 DUSP16 DOCK9 TIA1 DOCK8 TNK2 DOCK7 WASL ADAP1 ARHGAP4 ESRP2 SH3PXD2A PTPRZ1 RAMP2 TAGAP CSN2 CALCA PLEKHG3 TIAL1 RAMP3 PLEKHG4 SH2D2A CALCB PLEKHG1 PAG1 CALCR RANBP10 CALCRL ARAP1 GMIP ADM2 PTPRO ARFGAP3 PTN ADM ARFGAP2 IAPP AXL PLAT RAMP1 ARHGAP10 FAM83D CDC42EP5 FAM83A CDC42EP4 MXD4 CDC42EP3 LTK CDC42EP2 THBS4 WAS THBS3 PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B ITGAV COL4A2 NCAM1 ITGA5 COL4A1 PTPRS SPARC ITGB5 SERPINE1 SPOP ITGB6 ITGA2 ITGA8 TGFB2 TGFB3 COL9A1 COL9A3 COL9A2 CHD3 BMI1 RING1 HDAC4 HDAC2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 AMER1 NPHP4 GSK3B CSNK1A1 AXIN1 APC OPN1SW CDC73 LEO1 HHAT SHH DHH ATF1 CREBBP IRAK4 SP1 MAPKAPK3 BCL2 AREG BCL2L1 MYOG PTPN6 MYOD1 TACR2 MYF6 TACR3 TCF4 TAC3 TACR1 MYF5 TAC1 CAMK4 HHIP NTF4 S100B NTRK2 DISP2 SAA1 BDNF ULK3 SCUBE2 TAB3 DZIP1 TGFA TAB2 FOS SPOPL FOXO3 ELK1 PTK2 EREG UHMK1 BTC MC2R EPGN AKT3 JUN FZD7 WNT5A ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SPPL2B SPPL2A CX3CR1 ATP2A3 CLIP3 NSMAF ATP2A2 ATP2A1 PRKG2 OPN3 RRH PTGIR RGR PLA2G4A OPN5 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 RXFP2 RXFP3 CRHBP PDE11A CMKLR1 PDYN AGTR2 FPR3 GALR3 GALR2 NOS3 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 PTH1R UCN3 UCN2 GPR37 PDE10A GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR CDC14A MTNR1A MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 APLN GPR37L1 TAS2R19 KEL TAS2R42 HGS TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R DUSP4 SSTR1 DUSP3 SSTR2 VRK3 WNT16 DUSP6 SSTR4 DUSP7 SSTR5 CORT MAPK7 NPY4R OPRL1 PTHLH CNR2 CNR1 PIP5K1A TSHR PIP5K1B ACKR1 GOLGA7 ZDHHC9 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR TRRAP CCP110 AGT AR CFTR GATA3 SNX3 RHOT1 CSNK1G2 RCE1 ZRANB1 STAM CYLD OTUD7B RAB4A IKBKG RIPK2 UCHL5 KAT2B PIK3CD KAT2A NEDD8 USP9X USP17L2 RNF146 YY1 RUVBL1 MAP3K7 USP8 CER1 USP7 USP4 USP2 STAM2 VCP TNKS ADRB2 FOXO4 RIPK1 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MDM2 TAB1 USP34 PTEN TNFAIP3 ARRB1 RGL1 ARRB2 TRAF2 AXIN2 TRAF6 BIRC2 BIRC3 USP13 USP15 TNKS2 USP21 OTUD3 CKB GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PPP1R1B PDE3A CCL4L2 HNRNPM RGS8 SNW1 PDE8B PDE8A PCP2 HNRNPF GRK3 GRK6 GPSM1 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 PDE7B PDE7A HNRNPH1 MEMO1 CTNND1 AMH NOG CTNNA1 PPP1CA SNAI1 PPP1CB TERT USF1 DDX5 CCR5 CXCR4 NPFFR2 OXTR NPFFR1 RGSL1 GRPR EDNRA EDNRB PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT YBX1 NTSR1 PTBP1 NTSR2 GPR17 NMB XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GCGR GPR4 GCG MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 KIT RGS17 HTR2B RGS19 HTR2C RGS13 ADRB1 RGS16 P2RY6 ADRA1D HTR2A P2RY2 P2RY1 ADRA1B HTR4 RGS21 CCK ADRA1A HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 COL6A2 ADRA2C HTR5A ADRA2B COL4A4 TAAR1 COL6A1 ADRA2A GPR143 COL4A3 ADRB3 ATF2 COL6A3 RBPJ COL4A5 COL6A6 COL6A5 MEF2C B4GALT1 SPINT1 HPN SPINT2 HGFAC POGLUT1 POFUT1 MYL9 VPS29 VPS35 WLS VPS26A TMED5 TLE5 SFN COL1A2 EZH2 HEY1 CASP10 HEY2 MYLK HELLS KLF16 PPARG PPARD SPP1 RICTOR MBD3 STAT1 GATAD2B GATAD2A SKI CCNT2 CDC25C PRDM4 BEX3 CFLAR MAPKAPK5 KMT2B FOXO6 FOXO1 SOCS3 ACVRL1 BMPR2 AMHR2 GDF2 TNFRSF10B SMAD9 TNFRSF10A SMAD5 GREM2 ZFYVE16 BMPR1B NFKB1 BMPR1A TNFRSF10D PIN1 FASLG E2F4 E2F5 SST IL2RA STUB1 TRIM33 CCNK CCNC THBS2 GALNT3 MUC20 SH3GL3 EPS15 SH3GL2 SH3GL1 WWTR1 YES1 SMARCA4 SYVN1 CLTB YAP1 WNT5B ROR1 ROR2 PRICKLE1 RELA WNT1 FZD1 RYK FZD8 RHOT2 RXRG ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 ITCH KLC1 GPAM KLC4 KLC3 KLC2 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH NF2 ACTR3 PRDM1 ACTR2 NR3C1 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B IRAK1 KIF5A NCKIPSD RAP1GDS1 KDM4C IL2 IL3 IL6 BMP2 TCF3 YWHAE PRR5 LEP DPY30 CHD4 YWHAQ YWHAG YWHAH TGIF1 TBP TGIF2 EED STK4 SAV1 STK3 MOB1B MTA2 LATS1 MOB1A LATS2 AMOTL2 PENK AMOTL1 REST CARM1 KRAS CHRDL1 MMP2 MAML2 MAML1 VGF PIP4K2A PIP4K2B PIP4K2C JUNB RNF111 MED1 PRKCB FSTL1 FSTL3 PRKCQ MAML3 NOTUM CRKL MAPKAP1 NEDD4L SORCS3 CGA C3AR1 C5AR2 C5AR1 C5 RET RARG CD19 ASH2L GLI3 GLI2 RSPO3 CD55 TCF12 RARB CDKN2B WWP1 PTPN18 PF4 PTPN12 CSF2 PTPN7 PTPN2 MEN1 MST1 PGR MST1R FKBP5 ABL1 FPR1 SKIL CDK8 TIMP2 CDK5 WDR5 CRH HDAC5 HDAC8 HDAC9 HDAC6 HDAC7 GPR84 RAB6A RBBP4 RBBP5 RAB4B RBBP7 PML HDAC10 HDAC11 SOX2 SOX9 RUNX3 CITED1 PARP1 PRMT1 SGK1 PTPRJ NPY TJP1 FAS CDK5R1 ATP1B4 KCTD6 CXCR1 CBX6 CXCR2 SMURF1 SMAD6 ESR2 NR4A1 NR2E1 CASP2 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 POMC CXCL1 BAX PHB1 ARAF PEBP1 ADGRE5 CSK JAK2 ADGRE3 MARK3 FGB BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 TNS4 TNS3 SYK LCK FYN F2 DBT DLD CLTC CXCL6 CXCL9 CLTA CXCL8 CXCL13 AP2A1 CXCL3 CXCL2 AP2A2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 AP2M1 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 AP2S1 CCL22 CCL21 CCL20 CXCL10 CXCL11 CXCL12 ACKR4 ACKR3 ACKR2 AP2B1 CCL28 CCL27 P4HB POU2F1 STAT5A PXN FLNA GLI1 GRAP2 SUFU BTRC NUMB MTA1 MTA3 PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 GNAO1 NAB1 NAB2 LYL1 F3 DNM2 ARC TRIB1 TPH1 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 ID1 ID4 FOSB ID3 CDK5R2 TGFBR3 LRIG1 SOCS6 SH2B3 IKBKE BAG4 MATK GIPC1 ANOS1 WNT3A OFD1 LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 CSNK1E SFRP2 WIF1 SOST IRS4 IGF1R CILP KDM4B DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 OPN1LW CGN F11R PRKCZ PARD3 SMC1A SMC3 STAG1 STAG2 RAD21 NRG3 NRG4 NRG2 H3-4 ARL13B PDE6D FABP5 FABP7 PLIN3 MGLL GGA3 PDK4 RASGRP3 PIK3AP1 IL5RA CSF2RB CSF2RA STAT5B NCOA2 IL5 IL3RA IL2RB NCOA3 GRB2 NR5A2 CTBP2 CTBP1 DNMT1 PPP5C TNF WNT10B STAT6 PDGFRB FOXA1 ZDHHC7 TLE3 PPID CAV2 GREB1 CHD1 MMP7 TFF3 TFF1 ZDHHC21 CXXC5 USF2 ZNF217 EBAG9 SMPD3 SMPD2 PSAP GSK3A NTRK1 KIDINS220 CRK UBE2L3 TNFSF10 FADD PPP3CC C1QBP SPTAN1 BCAP31 TJP2 FNTA OTULIN TRADD CASP8 FLOT1 FLOT2 DSP DSG1 UACA GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 TMED2 FCER2 RFNG MFNG MDK ACTA2 LINGO1 MAG OMG RTN4 GPC5 ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 UCN CRHR2 TSHB LYN PIK3CG PIK3R6 PIK3R5 BTK RALA CFL1 JAK1 TYK2 AAMP MKNK1 SPRY2 ALK AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 GIP FFAR1 GNAZ ADORA2B JAG2 ADAM17 RDH5 CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 SNAI2 OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 PTPRU WWP2 WDR11 SH2B2 LETM1 CMA1 TMEM59 FER TEC VMA22 GRAP GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 RNF43 ZNRF3 FAM91A1 RSPO2 TEX2 RSPO1 ARMCX3 LGR6 PKP4 LGR5 RASAL2 KLB RSPO4 STIP1 LGR4 DDRGK1 FLT3 PLXNA1 IRS1 ANKRD26 PDE3B IRS2 NSFL1C CPD PIK3CB PLXNB1 TCIRG1 ARHGAP11A IDE FGF1 ZNF512B FGF2 CAPZB FGF3 EFHD2 NCK2 PTPRF FGF4 WDR6 FGF6 NCK1 FGF7 DST FGF9 PLEKHG6 AKT2 NIPSNAP2 BLTP3B GRB10 ATP6V1E1 PARD6B SH3BP1 CTSD WHAMM ATP6V1E2 HRAS WASF3 ATP6V1G1 NDUFA5 PCDH7 ATP6V0B ATP6V0E1 SEMA4F ATP6V1G2 PTPN13 ATP6AP1 VAPB PDPK1 GOLGA3 GAB1 BAIAP2L2 KCTD13 FLT3LG FRS2 TMEM87A GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 SCFD1 SPTBN1 TLR9 EPO EPOR PIK3C3 CCDC88A TRIB3 FRAT1 ANLN FRAT2 ATP6V0D1 FAF2 KIF14 SOS1 SH3RF1 ATP6V0C AKAP12 ATP6V0D2 ATP6V1B1 GFAP HINT2 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 RHOH PIK3R1 RHOF INS RHOJ NRAS RHOU ATP6V0A2 RHOV FGF20 RHOQ THEM4 SAMM50 EMC3 ATP6V1H MTX1 MAPK1 ATP6V0A4 CAVIN1 MYO9A ATP6V0E2 ATP6V1G3 TRIP10 FGF23 RTKN PRAG1 ATP6V1D FGF22 SYDE2 ATP6V1C1 BASP1 ALDH3A2 ATP6V1F ATP6V1C2 ELMO2 DDX4 ATP6V0A1 MAPK3 ARHGEF28 PTPN1 ARHGAP19 INSR ARHGAP18 TOR1AIP1 PTPN11 FGF16 ARHGAP12 PLD2 FGF19 RHPN1 FGF18 RHPN2 FGFR4 FGF10 FAM83B ACBD5 MACO1 SHARPIN ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 CAMK2B DLG5 PICALM CAMK2D SRC DOCK5 ACTN2 DOCK4 ABCD3 CAMK2A NRG1 DOCK3 SOWAHC GRIN2B MTR TNFAIP1 RND2 GRIN2D GRIN1 RND3 RND1 DLG1 CKAP4 DLG2 SENP1 ZAP70 DLG3 GFOD1 LRRC7 ALS2 DLG4 NEFL PEAK1 CALM1 NDUFS3 DOCK2 CAMK2G DOCK1 CCDC187 IER3 MECOM MOSPD2 FAM169A PHLPP2 ADD3 PLK1 PHLPP1 PTK2B CD86 UBE2D1 CD80 HSPE1 ATN1 SLC4A7 ACTC1 SALL4 MAF1 PDHB TRAT1 RPS6KB2 CDK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 GLP1R VIPR1 VIPR2 RANBP9 SCT KAT5 GIPR GHRHR CHEK1 GLP2R SCTR GHRH VIP OPTN PPP1R12A SEM1 APP HGF CLIP1 PDGFB KNG1 IGF2 IGF1 CCR6 PPBP CCR2 TIMP1 S100A9 S100A8 PLG PLPPR1 PLPPR2 PLPPR3 ELANE PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PDGFRA GTF2A1 GTF2A2 BMP10 LTBP4 P2RY12 P2RY13 P2RY14 P2RY4 LTBP3 ADORA3 ADORA1 LTBP1 SCD FASN ITGB8 ULK1 TCF7L2 CDKN1A TCF7L1 HDAC1 LEF1 TCF7 FLRT3 CCND1 SIN3A CDK2 CTNNB1 MET PPP1R15A PTPRA SPTB TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB HSPB1 PSMD8 PSMD6 PSMD7 SPTBN4 XPO1 SPTBN5 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 ARTN PRKCD PRKCA GFRA1 YWHAZ GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 PSMA4 GFRA4 PSMA1 PSMA2 MAPKAPK2 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 CASP9 MMP14 MMP16 CASP3 XIAP C3 DHRS4 FURIN PCSK6 NGF PCSK5 IL1RL1 IL33 RNF20 SPEN IFT172 CCT2 IFT52 CPSF7 ROCK1 IFT57 ROCK2 DYNC2H1 IFT140 GPS1 ADAM12 RPGRIP1L CUL3 TXNL1 KIF7 WDR35 RHOBTB1 SRRM1 IFT88 SMO COPS4 TRA2B GPR161 COPS2 INTU TULP3 MYO6 STK38 KIF3A TTC21B PDE5A RBBP6 PTCH1 WDR19 VIM HNRNPC IFT122 FUZ CCT7 ADCY10 RBMX MKS1 DBN1 DTX4 TBK1 ELMO1 CD28 OPN1MW RASGRF1 RNF31 SPATA2 TNFRSF1A LIN7B OTUD1 TRIM27 HSP90AA1 NEDD4 MKRN1 EGF FRK CBL EGFR CDC37 PLCG1 CDKN1B CCND3 FNTB E2F1 RHO E2F3 GNAT1 TFDP1 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L PELP1 H2BC21 DOK1 MYB EP300 SFPQ IL6R RASA1 KHDRBS1 H3-3B KHDRBS2 H3C8 KHDRBS3 H2AC8 H2AC6 STAP2 H2AC7 SRMS BCAR1 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RARA CBFB H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CETP KDM3A HDAC3 KDM1A KDM1B GNAT3 GPS2 RXRB NRIP1 APOD GABRG3 UGT1A3 APOE GABRG2 TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 GABRB3 NR1H3 GABRB2 NCOR2 ARL4C GABRB1 EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ABCG1 GNAI3 GNAI1 GNAI2 GABRQ GABBR2 GABRA1 GABBR1 ST3GAL4 ST3GAL6 AVP ST3GAL3 MEF2D TAS2R20 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 NKX2-5 KAT2B WWTR1 TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 CCN2 HIPK2 TBX5 GATA4 NPPA ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 ITGB4 COL15A1 ITGA6 PLEC COL11A1 COL11A2 LOX COL10A1 COL27A1 COL24A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL6A3 BMP1 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CTSS TLL2 TLL1 LAMB3 LAMA3 LAMC2 COL1A1 COL1A2 MMP9 PXDN MMP3 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME ABCC5 GSTA2 NUDT15 IMPDH1 HPRT1 IMPDH2 GMPS GSTA1 SLC28A2 RAC1 SLC29A1 TPMT VAV3 NME1 ABCC4 SLC29A2 SLC28A3 GSTM1 NME2 XDH VAV1 VAV2 GUK1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination YAP1 CYP51A1 POU3F1 MPZ SREBF2 ADGRG6 LAMA2 DRP2 HMGCR PRX LAMB1 LAMC1 PMP22 SOX10 NAB1 NAB2 UTRN EGR2 DAG1 POU3F2 MAG HDAC2 TEAD1 WWTR1 SMARCA4 SCD5 MBP ADGRV1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 TRIM27 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PML UBE2I PIAS1 SUMO1 MDM2 NUP205 POM121 NUP107 NUP188 AAAS VHL NUP160 NUP214 POM121C NUP42 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ1 KCNJ16 KCNJ10 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 CNGA2 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 GNG13 GNB1 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC9 METTL23 H4C9 H2BC8 H2BC26 H2BC5 H2BC3 H2BC12L H2BC21 NPM2 H2BC1 H3-3B SRPK1 H1-8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HIRA H2AX PRM2 PRM1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 HNRNPA2B1 SOD2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 MIF SOD1 MTAP GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 PPIA SNRPA1 PAK2 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 CHMP3 CFTR CHMP6 CHMP7 UBA52 ARL13B HBB HDAC6 PLIN2 IFT88 UBB UBC RPS27A PLIN3 CHMP4C CHMP4B VPS28 TSG101 HSPA8 CHMP4A VPS37C VPS37D VPS37A VPS37B CHMP2B MVB12B PCNT CHMP2A MVB12A UBAP1 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer NTRK3 NTF3 PDGFB RICTOR FOXO4 ESR1 MDM2 CD28 PRR5 PTEN GSK3A EGF EGFR CDKN1B KLB FLT3 IRS1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 PDGFRA RAC1 PDPK1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 MAPKAP1 HBEGF RAC2 RHOG PIK3R2 PIK3R1 CDKN1A FGF20 FGF23 FGF22 CHUK MET BAD PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 MLST8 TSC2 ESR2 SRC NR4A1 MTOR NRG1 AKT1S1 AKT1 PIK3AP1 GSK3B CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 RPS6KB2 PIK3R5 STRN PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA FOXO3 HGF EREG CASP9 BTC EPGN AKT3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism CYP27B1 GC PIAS4 CYP24A1 CYP2R1 LRP2 SUMO2 LGMN UBE2I VDR LDLRAP1 CUBN MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis PPIA HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 PARP1 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 FEN1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A POLQ GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALK1 PGM1 GALE GALM GALT AKR1B1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CCNB1 CDK1 ORC5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF COL4A2 COL4A1 SOS1 FURIN STAT3 PIK3R2 PIK3R1 PDGFB NRAS SPP1 COL6A2 COL4A4 COL6A1 COL4A3 STAT1 PTPN11 COL6A3 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 SRC PLG CRK STAT5A STAT5B THBS1 PLCG1 THBS2 PDGFD PTPN12 PIK3CB RAPGEF1 PLAT NCK2 NCK1 THBS4 RASA1 THBS3 PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis PEX3 ABCA10 ABCG4 ABCA3 ABCD2 ABCA6 ABCA2 ABCA5 ABCG1 ABCA9 ABCD3 ABCA7 APOA1 ABCD1 ABCA12 ABCG8 PEX19 ABCG5 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5PO SAMM50 MTX1 APOOL CHCHD3 DMAC2L HSPA9 ATP5MC2 ATP5MC3 ATP5MK ATP5MJ MICOS13 MT-ATP6 MICOS10 ATP5MC1 CHCHD6 ATP5MG ATP5MF ATP5ME APOO DNAJC11 IMMT TMEM11 ATP5F1A ATP5F1B ATP5PF MTX2 ATP5PD WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 CLTC CLTB PRKCA FZD4 WNT5A AP2S1 CLTA AP2A1 AP2A2 AP2B1 AP2M1 PRKCB DVL2 PRKCG ARRB2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation KDELR1 SEL1L RNF185 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 MGAT3 KDELR2 SAR1B COPB2 COPA TMED10 B4GALT6 DERL1 B4GALT5 DERL2 MAN2A2 SERPINA1 RNF5 OS9 COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 TMED7 TMED9 COPZ2 BET1L COPZ1 USO1 ARF5 NAPA GBF1 NAPB SPTAN1 RAB1A RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 GORASP1 B4GALNT2 ARCN1 COPG2 COPG1 B4GALT2 B4GALT3 B4GALT4 CGA RPN2 TUSC3 PRKCSH DCTN6 RPN1 DCTN5 DCTN1 MAGT1 DCTN4 FUT8 GANAB MAN2A1 MGAT5 CAPZA3 MGAT1 MGAT2 CAPZA2 COL7A1 OST4 EDEM2 ACTR10 MOGS ARF3 SEC31A DDOST MGAT4C TMEM258 DAD1 OSTC TMED2 MGAT4A CALR CANX SPTB MGAT4B STT3A STT3B B4GALT1 MAN1B1 ANK2 ANK3 CD59 CD55 SPTBN4 SPTBN5 SPTBN2 ASGR1 ASGR2 UBA52 ACTR1A ARF1 SPTA1 PDIA3 CSNK1D UBB UBC RPS27A CAPZA1 DCTN2 DCTN3 UMOD LMAN1 GOSR2 PSMC1 YKT6 ARFGAP1 PREB SRD5A3 KDELR3 VCP FUCA1 TRAPPC4 SEC22B LHB SEC23A SEC24B GLB1 SEC24A STX5 RAD23B ANKRD28 SEC13 PPP6C PPP6R3 SEC24D SEC24C TRAPPC1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 CTSZ DYNLL2 NSF CTSC DYNC1I2 DYNC1I1 DYNC1H1 GRIA1 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT TFG GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 COPB1 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS GOLGB1 DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 ANK1 SLC17A5 ST8SIA5 AREG ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 UBXN1 ST8SIA2 NGLY1 RNF139 GFPT2 MLEC PMM2 TGFA ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria BAX CYCS BAK1 GSDMD DIABLO GSDME DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBIN HSP90AA1 ERBB2 CDC37 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGA5 FN1 ITGB1 CEACAM1 CEACAM6 CEACAM8 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation SGSH AGRN NAGLU GPC1 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 HSPG2 SDC1 CTSL HPSE SDC4 HPSE2 SDC2 SDC3 IDS UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria E2F1 BBC3 TP63 TP73 PPP1R13B TP53 TFDP1 TFDP2 TP53BP2 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GUSB ARSB GYG1 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 ALDOB EPM2A DCXR GNS SI PPP1R3C LCT HGSNAT NHLRC1 GAA G6PC3 UBB SGSH UBC TALDO1 KHK RPS27A GALNS NAGLU SLC37A4 RPIA IDUA HYAL1 GLB1 IDS SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF10 LAMA5 FGF2 LAMA2 LAMB3 LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection AP2A1 AP2A2 NPM1 AP2M1 CCR5 CXCR4 AP2S1 AP2B1 TAF4B TBP TAF9 TAF1L NMT1 BTRC TAF15 TAF12 TAF13 TAF11 TAF8 KPNB1 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C CHMP4B CHMP4A RAC1 GTF2A1 CHMP2B GTF2A2 GTF2B CHMP2A GTF2E1 GTF2E2 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 TAF7L FEN1 PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 RNMT CCNH PSMA5 PSMA6 POLR2A PSMA3 POLR2B PSMA4 POLR2C PSMA1 POLR2D POLR2E RAN PSMA2 POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J ARF1 PSMD12 POLR2K PSMD11 POLR2L RNGTT GTF2H1 PSMD14 GTF2H2 GTF2H3 PSMD13 SUPT5H PSMA7 GTF2F1 GTF2H4 PSMB6 GTF2F2 GTF2H5 PSMB7 CDK7 ERCC3 PSMB4 ERCC2 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PPIA PSMC5 PSMC6 PSMC3 TAF9B PSMC4 PSMC1 PSMC2 PAK2 FURIN AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NMT2 LIG1 RCC1 TAF10 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 XRCC6 XRCC4 XRCC5 LIG4 RANGAP1 ATP6V1H DOCK2 CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 HCK SEM1 LCK FYN SKP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 EPB41L1 KCNMA1 KCNMB1 CASK KCNQ4 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A MYH9 TMC2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 USH1C SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters SLC17A1 SLC20A2 SLC34A3 SLC34A2 SLC20A1 SLC34A1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events H2BC9 CHMP3 H4C9 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 H2BC1 H2AC20 H2AC1 HNRNPK H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 H2BC18 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 NUP37 VPS36 VPS25 SNF8 CHMP1A H2AC19 H2BC26 H2AC14 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 CEBPD H2BC17 VPS4A CHMP2B H2BC12 MVB12B CHMP2A H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 H3C15 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport KDELR1 KDELR3 DYNLL1 FOLR1 INS BET1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 COG8 COG7 COG6 NSF COG5 COG4 COG3 CAPZA3 COG2 COG1 CAPZA2 DYNC1I2 ACTR10 ARF3 KDELR2 COPB2 COPA TMED10 TMED2 SPTB DYNC1I1 DYNC1H1 COPE ARF4 ANK2 ANK3 CD59 CD55 SPTBN4 TMED3 SPTBN5 SPTBN2 TMED7 TMED9 COPZ2 COPB1 BET1L STX5 COPZ1 USO1 ACTR1A ARF1 ARF5 GOLGB1 NAPA GBF1 NAPB SPTAN1 SPTA1 RAB1A RAB1B GOSR1 GOLGA2 NAPG ARFGAP3 ARFGAP2 CAPZB DYNC1LI1 GORASP1 ANK1 DYNC1LI2 ARCN1 DCTN2 CAPZA1 DCTN3 COPG2 GOSR2 COPG1 YKT6 TMEM115 ARFGAP1 SPTBN1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis B3GNT5 B4GALT6 B4GALT5 FUT2 FUT1 ST8SIA5 UGCG ST3GAL5 UGT8 ST3GAL2 ST3GAL3 B4GALNT1 GAL3ST1 CERK B3GALNT1 B3GALT4 ST6GALNAC5 ST6GALNAC6 A4GALT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RAPL1 IL1RL2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism GCDH HYKK AADAT PIPOX SLC25A21 CRYM AASS DHTKD1 ALDH7A1 DLST PHYKPL DLD TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR2 ARRB1 ARRB2 TGFBR3 TGFB2 TGFB1 GIPC1 TGFBR1 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease SOS1 CEP43 STAT3 PIK3R1 ERLIN2 NRAS FGF20 FGF23 FGF22 STAT1 FGF16 FGF18 FGFR4 FGF10 ZMYM2 FGFR1OP2 POLR2A BAG4 POLR2B STAT5A STAT5B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRIM24 PLCG1 POLR2I FGFR3 POLR2J POLR2K POLR2L GTF2F1 CPSF6 GTF2F2 FGFR1 MYO18A LRRFIP1 CUX1 BCR NCBP1 NCBP2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 GAB2 PIK3CA SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs RPS6KA1 CLTC CLTA AP2A1 AP2A2 FURIN NTRK3 PCSK6 NTF3 NGF PCSK5 AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB PTPRO VGF EP300 JUNB RAC1 HRAS GAB1 FRS2 MAP2K1 CRKL MAP2K2 PIK3CA TIAM1 SOS1 DUSP4 DUSP3 VRK3 PTPRS DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 PTPN11 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 SRC ADCYAP1 ADCYAP1R1 YWHAB SHC2 DOCK3 SHC3 RALGDS GRIN2B DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA BAX ATF1 NELFB BRAF MAP2K5 RAPGEF1 MAPKAPK3 FRS3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTF4 NTRK2 BDNF FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f MPDU1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS ABCC2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling PRKCA SOS1 SH2B2 LYN CBL PTPN6 YES1 LCK FYN KIT SOCS6 SH2B3 SOCS1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) PTPRO SOS1 PTPRS NTRK3 NTF3 PIK3R1 NRAS PLCG1 SRC BAX HRAS PIK3CA NELFB IRS1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A7 SLC4A4 AHCYL2 SLC4A8 SLC4A9 SLC4A10 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion INMT RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins OCLN APC DSG1 DSG3 PLEC ADD1 BIRC2 ROCK1 SPTAN1 LMNB1 CTNNB1 DBNL TJP1 ACIN1 GAS2 MAPT BCAP31 VIM GSN CLSPN TJP2 FNTA DSG2 PKP1 CDH1 BMX SATB1 STK24 STK26 PRKCQ CASP8 CASP6 PTK2 CASP7 DSP CASP3 PRKCD TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands IGFBP3 TNFRSF10C TP63 TP73 PPP1R13B TNFRSF10B TNFRSF10A FAS TP53 TMEM219 TNFRSF10D TP53BP2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR DLAT PDHX PDHA2 PDHA1 PDHB DLD GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR LYN STAT3 SOCS3 ADAM17 PTPN6 MAPK1 JAK2 SOCS2 CISH STAT1 MAPK3 PTPN1 SOCS1 IRS1 IRS2 GH1 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) SEL1L ERLIN1 ERLIN2 RNF185 VCP PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA1D GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY6 CACNA1C ADCY5 GNGT2 ADRA2C ADRA2A CACNB3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 GNAI1 CACNB2 GNAI2 GNG10 GNG12 GNG11 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA PRKCA ANP32A ELAVL1 XPO1 TNFSF13 NUP214 SET PRKCD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0D1 ATP6V1G1 ATP6V0B ATP6V0C ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V1H LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 CDH1 SH3GL1 CTNND1 UBA52 SRC STAM STAM2 CBLL1 CTNNB1 MET HGS UBB SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 ADCY9 TAS2R16 FZD8 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 PDE11A CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 PDE10A GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH TRIO MAS1 RASGRF2 XK ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 WNT6 VAV3 HCAR1 WNT2 ARHGEF11 PTCH2 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ WNT2B ARHGEF15 PLEKHG5 HEBP1 ADGRE1 ARHGEF17 GRM3 ARHGEF16 ADGRE2 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 WNT16 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN ACKR1 FGD1 FGD2 GNA13 FGD3 ABR FGD4 C5AR2 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 WNT3 WNT8A WNT8B PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 CCL11 CCL3L3 PRKACG CXCR5 CCR5 CXCR6 PRKACA CCL7 CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 RGSL1 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HBEGF HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA WNT3A WNT9A PAK1 C3 ROCK1 ROCK2 SMO PTCH1 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants CEP43 STAT5A STAT5B STAT3 PIK3R1 TRIM24 ZMYM2 CPSF6 FGFR1OP2 GAB2 MYO18A STAT1 PIK3CA LRRFIP1 CUX1 BCR FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 TEC IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 VAV3 PPP3CA PPP3CB PPP3R1 VAV1 VAV2 SOS1 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN BTK NFATC3 TXK SYK AHCYL1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation GCSH DLAT LIPT2 LIPT1 NDUFAB1 DLST FDX1 NFU1 DBT LIAS TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 PCNA UBC RFC3 RFC4 POLK RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly CHMP3 CHMP6 CHMP7 RANGAP1 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 PPP2CA TUBA3E TUBA3D TUBA3C UBE2I SUMO1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 TNPO1 NUP160 NUP85 NUP62 BANF1 SIRT2 NUP43 RAN NDC1 CCNB1 TUBB8 SEC13 NUP155 NUP133 IST1 VRK1 CDK1 LEMD2 NUP93 TUBB8B NUP35 EMD NUP54 LBR NUP37 KPNB1 SPAST CC2D1B LEMD3 PPP2R1A TUBB6 TUBB3 TUBB1 PPP2R2A CHMP4C RCC1 CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A CCNB2 AHCTF1 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 RXRB PLIN1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import PEX10 PEX12 PEX13 PEX14 SLC27A2 DHRS4 NUDT7 CRAT PECR ZFAND6 PEX26 SCP2 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 ECH1 PIPOX GNPAT ACOT2 ACOT4 UBE2D2 UBE2D3 NOS2 HACL1 HAO1 DECR2 HAO2 EPHX2 IDH1 TYSND1 UBE2D1 AMACR DAO CAT CROT UBA52 PEX2 PEX1 BAAT PEX7 UBB ACOX2 ACOX1 IDE UBC EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 AGXT PAOX HSD17B4 DDO HMGCL USP9X TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 PLK3 CNOT1 CNOT2 CNOT3 NPM1 CDC25C RGCC PLAGL1 TNKS1BP1 CNOT10 PLK2 CNOT8 CNOT9 CNOT6L CNOT11 TP53 BTG2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site CANX CALR INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling LCK JAK3 STAT5A STAT5B PTK2B SHC1 IL2RB JAK1 IL2RG IL2RA IL2 SYK BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA PHF1 H2BC9 H2AZ2 H4C9 JARID2 H2BC8 H2BC5 EED H2BC3 H2BC1 EPOP H2AC20 AEBP2 MTF2 RBBP4 EZH2 RBBP7 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EZHIP PHF19 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 EZH1 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 AR CFTR BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 NCOA2 PTK2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NCF1 ATP6V0D1 NCF2 ATP6V0C NCF4 ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H HVCN1 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F NOS1 ATP6V1C2 CYBB ATP6V0A1 CYBA LPO TCIRG1 SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B MPO ATP6V0E1 NOS2 ATP6V1G2 NOS3 ATP6V1B2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins NUP85 TPR PCNA NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 INCENP NUP50 BIRC5 NUP35 NUP54 NUP37 TOP2A AURKB PIAS3 SUMO3 SUMO2 UBE2I CDCA8 SUMO1 TOP2B TOP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle TRAK1 TRAK2 RHOT1 RAP1GDS1 MYO19 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS FMOD HEXB HEXA GNS GLB1L3 PRELP GLB1L2 OMD KERA GLB1L GLB1 ACAN OGN LUM RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 BRK1 ABI2 ABI1 ARPC1B ARPC1A ABL1 BTK MAPK1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ACTG1 MAPK3 ACTB CDC42 NCK1 WAS NCKIPSD WIPF1 WIPF2 CYFIP2 WIPF3 RAC1 WASF3 NCKAP1L WASF1 WASF2 PTK2 CYFIP1 NCKAP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PIP5K1C ARHGAP32 FURIN RPN2 PCSK6 JUP PRKCSH RPN1 GANAB CSNK2A3 PCSK7 CTNNB1 POMT2 SPCS3 SPCS2 SPCS1 OST4 SEC11A POMT1 SEC11C MOGS DDOST TMEM258 DAD1 OSTC CANX STT3A CDH1 CSNK2A1 CSNK2A2 ANK3 CSNK2B TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP BLM CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 CHTF18 RFC2 RFC1 STN1 RPA1 TEN1 RPA2 RPA3 DNA2 CTC1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 HRAS SOS1 NTF4 NTRK2 BDNF FRS3 FRS2 NRAS PTPN11 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism SLC2A1 CYB5R3 SLC2A3 CYB5A SLC23A2 SLC23A1 GSTO2 GSTO1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 PSIP1 PPIA HMGA1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release CANX CALR DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 GALK1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 IGHV3-23 V1-13 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-8 V1-20 IGHV3-33 IGKV1D-39 IGKV1D-33 V1-9 V5-4 IGKV2D-28 V1-7 IGKV4-1 V5-1 IGHV7-81 V1-5 V1-3 IGKV2D-30 V5-6 IGHV4-59 IGHV1-69 C1QB C1QA C1S IGLV2-11 C1R IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 V4-6 V4-2 IGKV3-15 V4-1 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 C1QC IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CRP IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair MBD4 H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 SMUG1 NEIL3 H2BC3 H3-4 PARP1 NEIL2 H2BC1 POT1 TERF2IP NEIL1 H2AC20 MPG FEN1 POLB H2AX PNKP LIG1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLE POLD2 OGG1 H2BC21 RFC2 RFC1 PARP2 LIG3 RPA1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 XRCC1 H2BC14 POLE4 H2AJ RPA3 H2BC15 H2BC11 POLE2 POLE3 PARG NTHL1 APEX1 ADPRS TDG MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 ABL1 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 MYBL2 DHFR TK1 CDKN2D CDKN2C CDKN1C RB1 DYRK1A CDKN1B CCND3 RRM2 CCND2 E2F1 RBBP4 E2F2 E2F3 SKP2 CABLES1 FBXO5 CDK6 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 TOP2A PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDKN2A CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN CCNB1 PSMA2 UBA52 CDKN2B PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 JAK2 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PPP2R2A PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBIN HSP90AA1 ERBB2 CDC37 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR FLRT1 SOS1 PIK3R1 NRAS FGF20 MAPK1 FLRT3 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 PTBP1 HNRNPM TGFBR3 HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L GIPC1 ANOS1 FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 SPRED2 SPRED1 ESRP2 KLB TIAL1 BRAF UBB GALNT3 PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 FMOD PRELP CHST6 OMD KERA ACAN OGN LUM ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions GJA10 PANX1 PANX2 GJD2 GJC1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation ARHGDIA NGFR NGF RHOA REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression CREBBP MAFK RELA NFE2L2 EP300 NFKB1 MYC NOTCH1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation ALDH1B1 ADH7 ACSS1 ADH5 ADH6 ADH1C ALDH1A1 ALDH2 ADH1A ADH4 ACSS2 ADH1B EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA1A XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGEF1 ARHGAP32 RHOC ARHGEF5 PIK3R1 RHOA ROCK1 CAVIN1 ROCK2 ABR RTKN ARHGEF28 ARHGAP18 MCF2 ACBD5 MACO1 FMNL3 ABCD3 FMNL2 ARHGDIA CIT ARHGEF25 CCDC187 PKN3 IQGAP1 TFRC IQGAP3 STX5 ARHGAP1 ARHGAP39 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK C1QBP LBR TMPO BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 LMAN1 STOM MCF2L ARHGEF40 RACGAP1 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 VAPB DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants HRAS NRAS KRAS SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border MSX1 DLX5 TFAP2A FGF4 TFAP2B BMP4 MYB TCF7L1 TFAP2C PAX7 POU5F1 SOX2 PAX3 ZIC1 WNT3A CTNNB1 GBX2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 TF CALU SERPINA1 MBTPS1 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 LAMB2 PDIA6 MXRA8 SPARCL1 FN1 LAMB1 SCG2 LAMC1 TGOLN2 STC2 PENK IGFBP7 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC GAS6 APLP2 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC22A5 PPARD CYP4B1 FAAH NUDT7 ACSM3 PCCA CRAT ECI1 PCCB THRSP ACSM6 PTGDS ACAD11 ACAD10 PLA2G4A GGT5 PTGES GGT1 DECR1 ALOX15B LTC4S GPX2 ACADL HADHB HADHA ACADVL ACADM ACADS CBR1 CYP2C9 NDUFAB1 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 SLC27A1 HACD1 TECR HSD17B3 PTGES2 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ACOT9 ELOVL1 OLAH CYP8B1 ELOVL4 ACOT7 ACSL1 MECR ELOVL5 ELOVL2 ACAA2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 HADH ACSL3 ACOT1 TECRL ACSF3 ACLY RXRA SCD FASN ACOT11 PPT1 ACOT12 ACSBG1 ACOT13 PPT2 SLC27A3 ACSBG2 SLC27A2 DPEP2 DPEP1 ALOX15 PECR THEM4 LTA4H PTGES3 CYP4F3 CYP4F8 SCP2 MCAT CYP2J2 NUDT19 ACBD7 PRXL2B ACBD6 ACOT7L ACAA1 ACBD4 PRKAA2 PHYH ACOT8 ACSF2 PRKAG2 MCEE ACBD5 PTGR1 ACOT2 CYP4A22 PTGR2 DBI ACOT4 PCTP ACOXL PRKAB2 ECHS1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 HACL1 PON3 HPGD DECR2 PON2 HAO2 PON1 EPHX2 FADS2 HPGDS FADS1 AMACR ALOX5AP MAPKAPK2 CROT CYP4F22 CPT2 MID1IP1 THEM5 SLC25A20 CPT1B ABCD1 CPT1A CYP4F11 SLC25A17 ACOX2 TBXAS1 EHHADH ACOX3 GPX1 GPX4 FAAH2 AKR1C3 HSD17B4 MMAA MMUT AWAT1 ALOXE3 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP3A7 CYP2E1 CYP2F1 ARNT AHRR CYP2W1 CYP2D6 ARNT2 CYP3A5 CYP2C18 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2J2 CYP2S1 CYP3A4 CYP1A2 CYP3A43 CYP2A7 CYP1A1 CYP2A6 AHR CYP2C19 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry AGRN ACE2 FURIN GPC1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 HSPG2 VCP TMPRSS2 NRP1 SDC1 CTSL SDC4 SDC2 SDC3 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus SQSTM1 UBC RPS27A NGF TRAF6 UBA52 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 MAPK8 ITGB3BP NGFR UBB FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 FGF23 FGF22 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B REST SRF NR3C1 KCNIP3 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members PMEPA1 FURIN BAMBI CER1 STRAP TGFB1 UBE2M TGFBR1 TGFBR2 SKIL SKI CDK8 SMAD2 TIMP2 SMAD1 SMAD4 SMAD3 YBX1 SMURF2 SMAD7 BMP2 TIMP1 CCNT2 TCF3 ARRB1 ARRB2 TGIF1 TGIF2 CBL USP15 TFDP1 TFDP2 PPP1CC CHRDL1 FGF2 EP300 JUNB PARD6A CGN F11R RNF111 PRKCZ PARD3 FSTL1 FSTL3 BMP10 LTBP4 RARA ITGB3 ARHGEF18 LTBP3 ITGB1 LTBP1 ITGAV NEDD4L RXRA ACVRL1 BMPR2 AMHR2 GDF2 SMAD9 ITGB8 SMAD5 ITGB5 SERPINE1 GREM2 ZFYVE16 PARP1 BMPR1B BMPR1A HDAC1 APH1A RHOA ITGB6 PSENEN MAPK1 NCSTN APH1B PSEN2 PSEN1 ITGA8 INHBB INHBA PPP1R15A INHA MAPK3 TGFB2 ATP1B4 TGFB3 NCOR2 TNRC6C MTMR4 MOV10 MYCN NCOR1 AGO3 AGO4 SNW1 MYC SMURF1 SMAD6 AGO1 TGFBR3 AGO2 TNRC6A TNRC6B E2F4 FKBP1A PPM1A E2F5 UBE2D3 TCF12 XPO1 RBL1 STUB1 UBE2D1 TRIM33 CCNK CCNC UBA52 AMH CDKN2B GIPC1 NOG COL1A2 FST PPP1CA FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C CCNT1 PPP1CB UBB UBC SP1 UCHL5 CDK9 RPS27A MYOG NEDD8 MEN1 MYOD1 WWTR1 MYF6 TCF4 MYF5 HELLS KLF16 USP9X MMP14 MMP16 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 CYP11A1 FDX1 FDX2 FDXR STARD3 STARD3NL AKR1B1 TSPOAP1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 MDC1 WEE1 YWHAB YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 YWHAZ SFN PIAS4 BRCC3 CCNB1 CDC25C CDK1 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 H2BC26 RFC3 RFC4 H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 CHEK2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 TP53 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase CDK2 BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants FLT3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis GAD1 GAD2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 RAD50 XRCC1 MRE11 BRCA2 FEN1 PARP1 PARP2 LIG3 RBBP8 NBN POLQ VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation PRKCA KDR ITPR1 ITPR2 ITPR3 RASA1 NRAS PLCG1 PRKCZ PRKCB HRAS AHCYL1 PDPK1 SPHK1 CALM1 PRKCD DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism SFTPA2 ABCA3 SFTPD SLC34A2 SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I VWF TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35A1 SLC35B2 SLC35B4 SLC35D1 SLC35C1 SLC35D2 SLC35A2 SLC35A3 SLC35B3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3 CREB3L4 CREB3L1 CREB3L2 MBTPS1 CREB3L3 CREBRF DCSTAMP MBTPS2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism TCN2 CD320 CUBN CBLIF MMAB AMN MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA AREG EGF EGFR PLCG1 EREG BTC EPGN LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations UGT2B7 CYP51A1 GSTA3 GSTA1 COMT CES3 HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CES1 FMO3 MAT1A CYP2C9 NNMT CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 AHCY SLC35D1 SLC35D2 CYP2D6 CMBL ALDH3A1 FDXR POR SULT2A1 CES2 MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 GSTM4 PTGES3 CYP4F3 CYP4F8 GSTK1 CHAC1 PODXL2 CYP27B1 ABHD14B SULT1A1 CYP26A1 SULT1C2 CYP26B1 SULT1B1 CYP24A1 SULT1E1 CYP26C1 CYP21A2 CYP2R1 BPNT2 AHRR BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 CYP4F12 PTGS1 NR1H4 AHR HPGDS CYP4F22 CYP19A1 GSTO1 CYP4F11 AIP NAT1 NAT2 TBXAS1 GSTA2 PAOX SULT1A3 GLYATL3 GLYATL2 ALDH2 GLYATL1 ACSM2A CYP3A4 ACSM5 GLYAT ACSM4 UGT1A9 CYB5B CYP4B1 CYB5R3 CYP27A1 CYP39A1 GSTP1 AOC1 MTRR CYP7B1 CYP7A1 MAT2B CYP8B1 TPST2 TPST1 CYP46A1 RXRA DPEP2 DPEP1 ARNT2 TPMT AS3MT AKR1A1 GSTT2 GSTT1 CYP11A1 ESD GSTT2B UGT1A3 GSTM3 CYP2J2 GSTM2 GSTM1 GSTM5 NCOA1 GSTO2 MAT2A GSTA5 GSTA4 CYP11B2 ARNT CYP4A22 ACSM1 ACSM2B PTGIS MTR NCOA2 POMC GSTZ1 CYP11B1 ADH1C ADH1A UGT1A10 UXS1 ADH4 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 ALDH1A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT2B17 UGDH UGT2B4 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A S100A9 LCN2 S100A8 LTF S100A7 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis ST3GAL4 FUT2 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism SLC26A2 SLC22A5 ABCB4 SLCO1B1 SLCO1B3 ABCD4 SLC2A1 SLC2A2 ABCC2 LMBRD1 ABCB11 OXA1L KGD4 NDUFAB1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 B4GAT1 TIAM2 CHST3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 PTGES3 B3GAT3 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UBE2I PIP5K1C ERCC2 GBA1 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GLYATL3 TP53 GLYATL2 GLYATL1 ACSM2A GNG10 ACSM5 GLYAT ACSM4 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 XDH GNA14 GNG3 GNA15 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 NUP37 PPP1CC PPP2R1B PPP2R1A PPA2 PPA1 RPS27 PPP2R5D DCXR AKR1A1 SORD CRYL1 XYLB IPPK IPMK ISYNA1 IP6K1 INPP1 IP6K2 NUDT3 NUDT4 VAC14 PI4K2B INPP5B MTMR10 NUDT11 PPP2CA NUDT10 PPP2CB MTMR2 MTMR12 INPP5A PIK3C2A IMPA1 PPIP5K1 MTMR4 MTM1 PLCZ1 IMPA2 INPP4A PPIP5K2 FIG4 PLCE1 INPP4B IP6K3 PIKFYVE MIOX INPP5F PI4K2A ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 ATIC OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS CPT2 GLUD1 MID1IP1 GLUD2 KYAT1 SLC25A20 CPT1B RIMKLA GLUL RIMKLB CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ADH1C ADH1A ADH4 RDH11 SIRT5 AKR1C3 MARCKS PRPS2 ALDH1A1 PRPS1 RPEL1 IDI1 MVK RPE SHPK TM7SF2 PGLS PMVK PRPS1L1 SC5D FDFT1 RBKS FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 NQO1 GSTA3 GSTA1 RAP1A PRKACG PRKACA PRKACB RAPGEF3 COMT BLVRB RAPGEF4 BLVRA CA12 CA1 CA3 CA5B CA2 CA5A CA4 CA7 CA6 CA9 CA14 CA13 PLCG2 GCHFR CHRM3 GCH1 SPR PTS PCK2 SLC37A1 G6PC2 G6PC3 RPS4Y2 FBP1 RPS27L FBP2 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 RPS24 B3GNT7 RPS23 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 GCKR GCK HSP90AB1 LYPLA1 CYGB DDAH1 PRKAA2 PRKAG2 PODXL2 ABHD14B SULT1A1 STK11 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 PRKAB2 SULT1A4 SULT4A1 SULT1A2 SULT1C4 MAN2B2 MAN2C1 LBR OCRL NAT1 NAT2 GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM ITPA CAV1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 HAS2 SPAM1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L SEC23A ASPA B3GALT6 B4GALT7 PNMT DDC TH DBH SEC24B SEC24A IQGAP1 PLD1 SEC24D SEC24C WASL TCN2 CD320 FUT3 TPST2 TPST1 NOSIP B3GNT3 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 AS3MT RPL32 GSTT2 HSPG2 RPL31 GSTT1 RPLP1 RPL34 ESD RPL10L GSTT2B GSTM3 RPL8 GSTM2 RPL10A GSTM1 RPL6 GSTM5 RPL7 GSTO2 RPL7A RPL18A MAT2A ACAN RPL36AL GSTA5 GSTA4 LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD RPL23 RPL22 RPL13A RPL9P9 SUMO2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 GPI ADPGK RPL26L1 ENO1 ENO2 ENO3 MRI1 ENOPH1 HK2 BHMT2 ENO4 HK3 BHMT ADI1 TPI1 PGAM1 PGAM2 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 PGK2 PFKL ECSIT GNPDA1 GNPDA2 PFKM PFKP CREBBP SP1 GLYCTK KHK GPT MED19 MED18 MED11 KCNJ11 ABCC8 ADCY9 ADCY4 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 MED21 ADCY6 ADCY5 CDK19 MED13L PRKG2 HEMK2 PLA2G4A GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC ITPR1 CHAC2 GGT3P ITPR2 GGT1 ITPR3 GCLM LRP8 APOB NOS3 CES1 DHFR TK1 GNAS HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC RAB5A KPNB1 TYMS SLC3A2 NSDHL LIPI CYP2D6 LIPH FDXR SULT2A1 STARD3 SLC36A4 ACOT9 STARD4 STARD5 ACOT7 MECR STARD6 STARD7 RUFY1 CH25H PRKD3 SLC6A12 FDX1 SLC7A5 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 CYP2E1 FAR2 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 HSD11B1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA CYP4F3 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE TSPO SPHK2 PTGR1 PTGR2 CYP21A2 AHRR SLC46A1 SAMD8 ECHS1 SGMS1 SGMS2 PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIAS4 VDAC1 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 ABHD4 ABHD3 INSIG2 INSIG1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 PLA2G12A CERS5 GPX1 ALDH1L1 CERS6 DHFR2 GPX4 FAAH2 MTHFR TNFRSF21 MTHFS ALDH1L2 CERS1 MTHFD1 CERS2 MTHFD1L PPM1L MTHFD2 HSD17B14 TPTE MTHFD2L LRP2 SLC25A32 CYP3A4 FOLR2 HSD17B11 SLC19A1 AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 TPH2 MBOAT1 ASMT DDHD2 AANAT MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PITPNB GBE1 CPNE7 PYGM ECI1 GYS2 PHKG1 CPNE6 PHKG2 GDE1 GYG2 ACSM6 CPNE1 EPM2A CPNE3 AKR1E2 PHKA1 PTGDS MFSD2B PHKB PHKA2 ACAD11 ACAD10 PPP1R3C MFSD2A NHLRC1 SACM1L SLC51A SLC51B PISD GALT CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS PANK4 CBR1 PCYT1B PANK2 PCYT1A PANK3 PANK1 STARD3NL DCAKD PLAAT1 PLAAT3 COASY PLAAT2 PPCDC CYP7B1 SLC25A16 NUDT8 PLAAT5 VNN2 PLAAT4 PPCS AKR1D1 ENPP2 GDPD1 ENPP3 ALOX12B GDPD3 SLC25A42 GDPD5 AASDHPPT HSD17B7 CYP7A1 MAT2B ORMDL2 HSD17B1 ORMDL3 HSD17B2 SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CKMT2 CYP8B1 GAMT GATM ETNPPL PLEKHA8 SLC6A7 PNPLA3 SLC6A8 PNPLA6 CKM CKMT1B ACAA2 INPPL1 SLC6A11 MSMO1 CKB CYP46A1 PLB1 ENPP6 SBF1 HADH SBF2 TPTE2 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PLA2G10 GPD1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 CHAT PLD4 PLD6 PLD3 ALDH3B2 EBP CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 ACBD6 ARG2 ACBD4 DGAT2L6 SLC25A2 CRLS1 ACSF2 CYP11B2 PI4KA DEGS1 ALPI DEGS2 PI4KB TNFAIP8 CYP4A22 DBI PCTP ACOXL ABCC3 PLA2G4F ABCC1 PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L PPP1CA NME1 PPP1CB MLXIPL FECH ACADSB ADIPOR1 ADIPOR2 NADK2 ACAD8 TYR UCKL1 DCT UCK2 UCK1 PUDP TK2 TYRP1 SLC5A8 SLC26A11 SLC26A1 ACO1 PLCB4 GCGR GCG SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLC5A6 COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ADSL PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS ADRA2C ADRA2A MT-CO1 B4GALT1 TKT SCO2 KCNG2 MT-CO2 MT-CO3 PPARGC1A PPARGC1B KCNC2 MED16 MED15 MED17 MED12 KCNB1 MED14 MED13 MED10 KCNS3 MED27 MED26 SIRT3 ALDH2 MED23 MED25 MED24 MED20 PPARG PPARA PPARD MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 RORA L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ODC1 ATP5MK COX11 AMD1 ATP5MJ OAZ1 COX14 SAT1 OAZ2 NDUFV3 SRM NDUFV2 ATP5MG OAZ3 MED30 NDUFV1 AZIN2 ATP5MF AZIN1 MED31 AGMAT ATP5ME SMS COA3 COA1 GOT1 UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 G6PC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 DMGDH NDUFB7 NDUFB6 CHDH SARDH COX4I1 NDUFB5 COX4I2 NDUFB4 ALDH7A1 SYT5 NDUFB3 NDUFB2 MLX ETFDH ALDH4A1 NDUFB1 PRODH FOXRED1 PRODH2 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 ARNT NDUFA6 FAHD1 NDUFA3 RRM2B NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 CCNC COX7B COX7C CTSL CAD COX8A DHODH SREBF1 UMPS COX8C COX5B COX5A COX6C GPAM COX6A1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C SAMHD1 VDR ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 PPM1K AUH QDPR IVD IL4I1 HIBCH PCBD1 ASRGL1 GALM RRM2 HGD TAT FAH HPD CARM1 LALBA NOSTRIN PNPO AOX1 XYLT2 XYLT1 B4GALNT2 NAMPT B3GALT2 PIP4K2A B3GALT1 PIP4K2B PIP4K2C FAM20B FUT4 FUT6 FUT5 FUT7 MED1 FUT9 B3GALT5 GALK1 PXYLP1 MED8 B3GAT2 B3GAT1 GALE MED4 MED6 MED7 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD CGA NR1D1 PIP4P1 GCSH SNAP25 GUK1 PAH GCDH HYKK AADAT SLC25A21 CRYM AASS CDA DHTKD1 CYB5A SLC23A2 SLC23A1 CIAO3 CIAO1 AFMID RIDA UROD NUDT13 NUDT12 NDOR1 NADK GNS UROS ALAS2 BCAT1 CYB5R3 DCTPP1 BCAT2 SLC45A2 ALDH6A1 KYAT3 ESRRA HIBADH THTPA NMRK2 TCN1 NMRK1 KMO PYGB COX10 NAXE PYGL PPOX CDK8 RRM1 NAXD HMBS ACMSD LHPP MMS19 MOCS2 MOCS3 RNLS TPK1 MOCOS CIAO2B SLC22A13 GSTP1 DTYMK HAAO GRHPR AOC1 TDO2 AGL IDO2 IDO1 QPRT SLC25A44 SLC25A51 SLC25A19 SLC25A28 SLC25A37 NUBP1 NUBP2 ENTPD2 GPX2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 GYG1 CD38 CPOX GPHN GLRX5 GLDC HOGA1 SLC19A3 SLC19A2 OCA2 SMARCD3 NMNAT3 NMNAT2 NMNAT1 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMT GLRX NADSYN1 NME3 NME4 ALAD DCTD TXNRD1 CMPK1 PGM2 KYNU CTPS2 CTPS1 PGM1 TTR COX7A2L TXN DERA BST1 VNN1 ARNT2 NFYA NFYB NFYC MANBA GAA NME2 BMAL1 CD44 COXFA4 COX7A2 COX7A1 SLC2A3 MAN2B1 POMC NAPRT PDXK GALNS UGT1A10 UXS1 UGT2B28 SLC9A1 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 BCKDK UGT2B15 BCKDHA UGT2B17 BCKDHB UGDH DBT UGT2B4 DLD UGT2B7 LDLRAP1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL LDLR GPIHBP1 MBTPS1 APOC3 ALB MBTPS2 FLAD1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 SERINC4 UCP1 HSD17B10 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA ALOX12 PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 PLCB3 CACNB2 PLCB1 PLCB2 CACNA1D DNM2 TPH1 EPRS1 TRMT112 CYP4F12 RAN ABCC5 ABCB7 NT5E ENTPD1 ENTPD5 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP RBP4 RBP1 LRAT ABO MMAB MTRR RTEL1 CBLIF MMACHC MMADHC INPP5E MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 LPIN2 MGLL LPIN3 PDK4 PEX11A CD36 NCOA2 NCOA6 NCOA3 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 PLIN2 BCO1 VKORC1 AKR1B10 CLPS PNPLA2 RBP2 LRP10 LRP12 PNLIP ADIPOQ DSEL DSE UST CHST15 ZDHHC21 ACSS3 AGPAT2 THRSP GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH TKFC ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 FMO3 NMT1 HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 SEPSECS QARS1 PSTK MARS1 INMT DARS1 SARS1 EEF1E1 AHCY KARS1 CBS IARS1 GNMT CTH SCLY CMBL ALDH3A1 POR CES2 BMX MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 APIP CYP2B6 EPHX1 CYP2S1 CYP4V2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 DUOX2 TSHB INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RPLP0 HSPA9 GSTO1 AIP TALDO1 MTAP GSTA2 AHCYL1 SULT1A3 MMAA MMUT PGD MCCC2 BTD PC PCCA HLCS MCCC1 PCCB ACACB FFAR1 TMLHE SHMT1 BBOX1 ALDH9A1 MTMR1 SHMT2 HMOX2 LETM1 GYS1 RHCE RHD PIK3CB NDUFA5 PTPN13 VAPB PIK3CA PIK3R3 PIK3C3 TRIB3 PIK3R4 PIK3R2 PIK3R1 STXBP1 INS THEM4 CACNB3 PLD2 CACNA1A ACBD5 CACNA1E ACSM1 ACSM2B MTR CALM1 NDUFS3 WDR26 PDHB RMND5B LDHA MPST TSTD1 MAEA SQOR PDPR GADL1 RMND5A SUOX ME1 NEK1 ADO CSAD PDK3 TXN2 DLAT TST PDK2 PDK1 ETHE1 PDHX SLC25A10 PDHA2 CDO1 PDHA1 GLP1R SIRT4 BRIP1 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 CYP11B1 HMMR SEM1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC PRSS3 PDZD11 PLA2G2A HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 CHPF OLAH CHSY1 ELOVL4 CHST11 ACSL1 ELOVL5 CHST12 CHSY3 ELOVL2 CHST13 SCD5 CSGALNACT1 ELOVL3 CHST7 ACSL6 CHPF2 ACSL5 CSGALNACT2 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 GSTK1 ASNS PHYH ACOT8 CHAC1 PIPOX BCS1L GNPAT ACOT2 STX1A ACOT4 COX19 COX17 ATP5MC1 PSMD8 HMOX1 PSMD6 HACL1 PSMD7 HAO1 CYC1 DECR2 PSMD2 HAO2 PSMD3 AKT1 PSMD1 NUP214 EPHX2 IDH1 PRKCA CS PSMA5 PSMA6 COQ2 PSMA3 AMACR PSMA4 DAO PSMA1 PXMP2 PSMA2 ACO2 MAPKAPK2 CROT UBA52 HSCB PSMD12 PSMD11 CACNA1C PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 TIMM21 BAAT UBB PSMB2 SLC25A17 ACOX2 PSMB3 UBC PSMB1 EHHADH AGPS PRSS1 RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PHYKPL ADRM1 CTRB2 PAOX CTRB1 NDUFB8 PSMC5 TAFAZZIN PSMC6 PSMC3 PSMC4 HSD17B4 PSMC1 PSMC2 DDO HMGCL ATP5F1A ATP5F1B IDH3G CYCS SRD5A3 NUDT7 VAPA CRAT IDUA NCAN HEXB HEXA LTC4S BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB HADHB HADHA ACADVL HSP90AA1 CYP17A1 PLCG1 NMT2 POLD1 EP300 RXRA HDAC3 GPS2 RXRB UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 NR1H2 NR1H3 NCOR2 NCOR1 TBL1XR1 FABP6 APOC2 PLIN1 HK1 AKAP5 GNAI1 GNAI2 MVD ST6GALNAC5 ST6GALNAC6 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 NEU1 CHD9 ST3GAL4 SLC17A5 ST8SIA5 ST3GAL5 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 TGS1 CTSA APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins OCLN DSG1 TJP2 DSG2 DSG3 CTNNB1 TJP1 PKP1 CDH1 DSP CASP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model SLC25A14 UCP1 UCP3 SLC25A27 UCP2 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm FOXF1 SHH IHH BMP4 GATA4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis CLTC CLTB CLTA DNASE2 CLVS2 CLVS1 ARF1 CTSZ BLOC1S1 GNS TXNDC5 HGS DNM2 AP4S1 AP4M1 AP1G2 DNAJC6 AP1G1 AP1S2 AP1S1 AP1S3 VAMP7 SH3GL2 AP1M2 HSPA8 AP1M1 VAMP2 AP1B1 VAMP8 APP CHMP2A AP4E1 M6PR ARRB1 AP4B1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SGTA STX5 STX1A VAPA VAMP2 BAG6 SERP1 SEC61G GET1 APP OTOF SEC61B HMOX1 GET3 EMD GET4 CAMLG UBL4A PRNP DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions ZNF217 STRAP HEYL ANGPTL4 TCF3 TGIF2 EED POMT2 POMT1 RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ANG RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ EML4 SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 NEK9 ZWINT NEK6 NEK7 KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 BTK GNGT1 GNG8 GNGT2 GNG10 GNG12 GNG11 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 ADORA2B GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B IL6 PRKAR1A PRKAR2A PRKX GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 DHFR TK1 RB1 CDKN1B RRM2 E2F1 RBBP4 SKP2 CABLES1 FBXO5 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 SOS1 YAP1 HBEGF GFAP SPARC SHC1 PIK3R1 NRAS APH1A ITCH PSENEN NCSTN APH1B PSEN2 PSEN1 GABRG3 APOE GABRG2 GABRB3 GABRB2 GABRB1 NCOR1 CXCL12 ESR1 WWOX ADAM17 SRC NRG1 DLG4 STAT5A NEDD4 GABRQ EGF EGFR GABRA1 UBA52 STMN1 WWP1 ADAP1 CSN2 UBB UBC RPS27A MXD4 HRAS S100B TAB2 EREG NRG3 PIK3CA PGR NRG4 NRG2 BTC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly COL17A1 ITGB4 LAMB3 CD151 ITGA6 PLEC DST LAMA3 LAMC2 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm OSR1 FGF2 FOXC2 FOXC1 BMP4 PAX8 PAX2 LHX1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 GSTZ1 PDP2 DLD FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway CENPX UBA52 MUS81 WDR48 SLX4 EME1 EME2 SLX1B FANCI UBB ATRIP FANCC UBC FANCD2 RPS27A DCLRE1B DCLRE1A FAAP100 UBE2T FAAP24 USP1 POLN FAAP20 FAN1 FANCM RPA1 FANCL FANCA RPA2 FANCB FANCE FANCG FANCF RPA3 ERCC4 ERCC1 ATR CENPS UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HBEGF HSP90AA1 CD9 HSP90AB1 TXNRD1 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family MUC15 MUC13 MUCL1 LYN MUC3A MUC5AC CLEC4C MUC3B CLEC4D MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 CLEC10A CLEC4A CLEC4E CLEC6A SYK FYN PLCG2 MUC12 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs CDC42 CTTN FLNA PPP1R12A PAK1 PAK3 LIMK1 RAC1 MYL12B MYL6 MYH9 MYLK MYH14 MYH11 MYH10 MYL9 NF2 PAK2 PPP1R12B PPP1CB CALM1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 DOCK3 RAC1 NTRK2 BDNF DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD SLC35D1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery SNRPD2 SNRPD1 SNRPD3 SNRPB SMN2 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 SNRPG RPS25 RPS28 RPS29 RPS20 FAU SNRPE RPS21 RPS24 RPS27 RPS23 SNRPF G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase E2F1 CDK2 E2F3 CCNA2 CCNA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes FMO3 CYP17A1 CYP4F22 CYP19A1 TPMT CYP7B1 MAT1A CYP11A1 CYP2U1 CYP1B1 CYP27A1 CYP11B2 AHCY CYP27B1 CYP11B1 TBXAS1 SLC35D1 CYP26B1 GSS OPLAH CYP24A1 CYP26C1 CYP2R1 CYP21A2 GCLC GGT1 GCLM FDXR ACY1 MAOA UGT1A4 FDX1 FDX2 UGT1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1 LHPP SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK PIK3CB SOS1 ALKAL2 ALKAL1 LTK TNK2 PIK3R2 PIK3R1 GRB2 PIK3CA IRS1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 GNG13 CDC42 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 ARHGEF6 GNG7 GNGT1 GNG8 PAK1 GNGT2 GNG10 GNG12 GNG11 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly NDOR1 RTEL1 POLD1 ABCB7 MMS19 BRIP1 ERCC2 CIAO3 CIAO1 NUBP1 NUBP2 CIAO2B VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways RELA NPM1 ITCH NR3C1 IRAK1 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 MED4 MED6 MED7 UBE2N VAV1 MAPKAP1 NEDD4L C4BPA C4BPB PTGES3 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB TAF7L FEN1 UBE2I SUMO1 C1QA C1S ELOB ELOC RBX1 VHL RNMT CCNH POLR2A ISCU POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 KPNA7 KPNA4 KPNA5 GBP1 KPNA3 CDK8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 PPP1CC PML DYNC1LI1 DYNC1LI2 RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 CD33 CHUK TJP1 DYNC1I2 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 BRD4 RPS18 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A TLR6 IKBKE IRF7 RAN NEK2 PDIA3 TUBB VPS36 VPS25 CBX1 SNF8 CHMP1A UBE2V1 CUL5 UBA7 UBA6 UBA5 UBR4 PAK2 IGF1R CAV1 UBA3 UBA1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A FXYD4 FXYD3 HYOU1 FXYD2 FXYD1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 NRP1 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 ARID4B SAP30 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD TAB3 TAB2 NFKBIB ELK1 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 SAP30L IFNA17 BAG2 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 PARP8 TUFM GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 DNAJC10 NMT1 VPS33B RIPK3 RAB5A KPNB1 TLR4 BCAP31 FNTA CHMP4C CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TAF9B KPNA2 MAP3K7 H2AC1 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA SCAP MAVS TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 CRNKL1 CDC40 ATP6V1H DHX9 CSTF3 CSTF2 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 DOCK2 CAMK2G HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 EFTUD2 PPP1CB CWC22 PAPOLA TXNL4A SNRPN ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 ACOT2 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B HSP90AA1 EGFR RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 CTSL ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 ATP7A ATP8B4 ATP8B3 ATP8B2 CAMK2B ATP8B1 SRI ATP4B CAMK2D ATP4A FXYD4 FXYD3 CAMK2A FXYD2 FXYD1 FXYD7 FXYD6 ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP7B CALM1 CAMK2G PDZD11 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants FLT3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GNAI3 GNAI1 GNAI2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development CLTB YAP1 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 MAG TEAD1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 POU3F1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 MBP ADGRV1 TYROBP DOCK1 MPZ ADGRG6 HMGCR ERBB2 PRX PMP22 SOX10 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM POU3F2 ANK1 SEM1 FYN CLTC CYP51A1 CLTA SREBF2 AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA2 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 SCD5 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 NAB1 MSI1 COL6A2 NAB2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 EGR2 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 DRP2 ROCK1 ROCK2 CNTN1 UTRN DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 HDAC2 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 WWTR1 YES1 SMARCA4 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CD4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism SLC26A2 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC CUBN AMN ABCD4 LMBRD1 GSS OPLAH GCLC GGT1 GCLM ACY1 SFTPD PPM1K AUH IVD HIBCH FMO3 GALM ADAMTS13 MAT1A POMT2 CYP2U1 G6PC3 POMT1 CYP1B1 POMGNT1 B4GAT1 AHCY DAG1 SLC35D1 LARGE1 APRT PNP ACACA HPRT1 FDXR ADA MAOA GALK1 CHSY1 GALE PRELP CHST6 OMD FDX1 KERA FDX2 NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 ACAT1 SFTPA2 MGAT2 PAPSS2 MOGS SDC4 SDC2 SDC3 B3GAT3 CYP27B1 SGSH CYP26B1 CYP24A1 CYP26C1 CYP21A2 CYP2R1 NAGLU B4GALT1 MAN1B1 ECHS1 GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 IDH1 UBA52 CYP4F22 CYP19A1 UBB TALDO1 UBC TBXAS1 RPS27A MMAA MMUT SFTPC PAH SRD5A3 MCCC2 BTD PC GBE1 PCCA HLCS MCCC1 GYS2 PCCB GYG2 EPM2A GNS PPP1R3C NHLRC1 CYP27A1 GALT B3GALT6 SLC37A4 B4GALT7 MMAB IDUA NCAN HEXB HEXA BGN DCN BCAN MTRR VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB GYG1 CYP17A1 GYS1 CYP7B1 PGM1 TCN2 CD320 CBLIF MMACHC MMADHC MUC13 G6PC1 SFTPB SFTA3 CHST14 SFTPA1 TPMT DCXR HSPG2 CYP11A1 GAA ACAN CYP11B2 LUM AGRN FMOD ABCA3 GALNT12 SEMA5A DPAGT1 SPON2 SEMA5B SPON1 THSD7B MPI MTR ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 CSF2RB THSD7A CSF2RA ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 ADAMTS12 DPM1 DPM2 THSD1 POMC ALDOB DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 SI MUC1 LCT MUC2 ADAMTS19 HGSNAT GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 CYP11B1 NEU1 SSPOP KHK MUC5B MUC20 MUC21 GALNS LFNG ST3GAL3 MPDU1 CTSA NUS1 UGT1A4 PMM2 GFPT1 DOLK SLC34A2 UGT1A1 BCKDK BCKDHA BCKDHB MC2R DBT DLD SLC25A15 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling LIFR CRLF1 TYK2 IL6ST STAT3 CBL SOCS3 IL6R LIF IL11 OSM IL6 OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA STAT1 CTF1 PTPN11 CLCF1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling FGF18 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 SPRED2 SPRED1 FGFRL1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding CLTC CLTB FTH1 CLTA FTL CTSZ BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 GNS SNAPIN AP3S1 TPD52 CLINT1 DNM2 AP4S1 AP4M1 AP1G2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 M6PR GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 STX4 SNAP23 DNASE2 CLVS2 IGF2R CLVS1 DTNBP1 ARF1 GOLGB1 NAPA RAB5C GBF1 TGOLN2 AP3B1 TXNDC5 HGS OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 APP CHMP2A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NEDD4L SERPINE1 FURIN PARP1 HDAC1 MAPK1 SKIL MAPK3 ATP1B4 SKI CDK8 NCOR2 SMAD2 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC E2F4 CCNT2 PPM1A E2F5 UBE2D3 RBL1 TGIF1 UBE2D1 TGIF2 TRIM33 CCNK CCNC UBA52 CDKN2B COL1A2 CCNT1 TFDP1 TFDP2 UBB UBC SP1 RPS27A CDK9 EP300 JUNB RNF111 MEN1 WWTR1 USP9X BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT FKBP1A NFATC2 NFATC3 PPP3CA PPP3CB NFATC1 PPP3R1 CALM1 PPIA GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI3 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 MCRIP1 SNAI2 KMT5A TGIF2 EED RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB CANX MGAT1 PRKCSH MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SNAPC5 SNAPC1 SNAPC2 SNAPC3 CCNT2 SNAPC4 ZNF143 PCF11 POU2F1 POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E SRRT POLR2F POLR2G POLR2H TAF9 POLR2I POLR2J POLR2K POLR2L TAF13 SUPT5H GTF2F1 TAF11 GTF2F2 ELL CDK7 CCNT1 TAF8 SUPT4H1 TAF6 TAF5 NCBP1 NCBP2 SP1 INTS1 INTS3 INTS2 CDK9 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 GTF2A1 ICE1 GTF2A2 ICE2 GTF2B SSU72 GTF2E1 GTF2E2 NABP2 NABP1 PHAX ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB1 DEFB104B DEFB109B DEFB136 DEFB135 DEFB134 CCR6 DEFB133 DEFB132 DEFB108B DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion CACNA1D GNG13 GNB2 GNAQ KCNJ11 GNB1 ABCC8 GNB4 GNB3 STXBP1 INS GNB5 ADCY8 GNGT1 ADCY6 ADCY5 GNGT2 RAP1A SLC2A1 PRKACG SLC2A2 PRKACA ADRA2C PRKACB RAPGEF3 SYT5 FFAR1 ADRA2A RAPGEF4 CACNB3 GNA14 CACNA1A CACNA1E STX1A GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 KCNG2 AKAP5 GNAI1 GNAI2 PRKCA IQGAP1 CD36 SNAP25 GNAS KCNC2 GCG CACNA1C CHRM3 GLP1R KCNB1 KCNS3 VAMP2 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CACNA2D2 MARCKS CACNB2 PLCB3 PLCB1 PLCB2 GNG10 ACSL4 ACSL3 GNG12 GNG11 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones HSPA5 MBTPS1 ATF6B MBTPS2 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM6 IRF1 NCAM1 TRIM5 IRF2 TRIM2 TRIM3 GBP1 CIITA HLA-H TRIM68 TRIM62 HLA-B TRIM46 HLA-C TRIM48 TRIM45 HLA-F TRIM35 HLA-G TRIM38 HLA-E OAS2 TRIM31 TRIM34 MAPK1 FCGR1BP IFI30 RAF1 TRIM29 TRIM26 TRIM22 MAPK3 MT2A TRIM17 SOCS1 PTPN1 IFNGR1 TRIM14 VCAM1 IFNGR2 TRIM10 PTPN11 SP100 CD44 MID1 YBX1 IRF8 B2M IRF6 IRF3 IRF9 SMAD7 CAMK2B PIAS1 HLA-A CAMK2D SUMO1 TRIM21 GBP5 CAMK2A GBP2 GBP6 GBP4 GBP3 TRIM25 IRF7 FCGR1A CAMK2G PRKCD IFNG PTAFR OASL OAS1 OAS3 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 JAK2 HLA-DRB4 JAK1 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 PML HLA-DQB1 ICAM1 SOCS3 PTPN6 IRF4 IRF5 GBP7 TRIM8 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) ATP6V0D1 SRPRB TPP1 PREB CXXC1 CXCL8 HDGF PPP2R5B KDELR3 SHC1 CREB3L3 ADD1 DCTN1 HSPA5 NFYA NFYB NFYC ATF6 CEBPB HERPUD1 CEBPG CCL2 ASNS SEC31A EIF2S2 EIF2S1 ERN1 EIF2S3 DDIT3 CREB3 CREB3L4 CREB3L1 ATF3 CREB3L2 ATF4 CALR EXTL2 MBTPS1 CREBRF DCSTAMP ATF6B MBTPS2 PLA2G4B EXTL3 HYOU1 KHSRP GSK3A EIF2AK3 DIS3 ACADVL PDIA6 DNAJB11 DCP2 SERP1 PARN WFS1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 TLN1 EXOSC8 DNAJC3 EXOSC3 EXOSC2 EXOSC1 CUL7 FKBP14 IGFBP1 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 HSP90B1 CTDSP2 SRPRA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema KLKB1 F2 F12 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A CPSF4 CHTOP CPSF7 CPSF1 FUS ALYREF CPSF3 CPSF2 SRRM1 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 CDC40 DDX39A ZC3H11A SARNP DHX9 DDX39B CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 UPF3B MAGOHB HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SLU7 SF3B4 FYTTD1 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 CASC3 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG13 GNB2 GNB1 GRIK3 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) YAP1 CREBBP DPPA4 DPPA2 LEUTX KDM4E EP300 TPRX1 TPRX2 ZSCAN4 TEAD4 TUT7 TUT4 DUX4 TP53 TPRXL DUXA DUXB AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC NQO1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 PPM1K SDSL AUH IVD QDPR SERINC2 IL4I1 PSPH HIBCH SERINC5 PCBD1 ASRGL1 SERINC4 HNMT SEPHS2 KGD4 RARS1 SECISBP2 MAT1A LARS1 HGD NNMT TAT FAH EEFSEC HPD AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 RPS17 SARS1 HSD17B10 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT SLC3A2 RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 SLC36A4 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 APIP RPS20 SLC6A12 HAL FAU RPS21 CARNMT1 RPS24 SLC7A5 UROC1 RPS23 AMDHD1 HDC CARNS1 FTCD CGA FMO1 ACAT1 PAPSS2 PAPSS1 ASNS TPH1 PIPOX EPRS1 ECHS1 PSMD8 PSMD6 PSMD7 HAO1 PSMD2 PSMD3 PSMD1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO GCSH PSMA5 IYD PSMA6 DUOXA1 PSMA3 DUOXA2 PSMA4 DUOX2 PSMA1 DAO TSHB PXMP2 PSMA2 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A MTAP SLC25A12 AGXT PHYKPL SLC25A13 ADRM1 PAOX PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DDO TP53 CAV1 GCDH PAH HYKK TPH2 AADAT ASMT SLC25A21 AANAT CRYM AASS DHTKD1 MCCC2 AFMID MCCC1 RIDA BCAT1 AGXT2 BCAT2 SLC45A2 ALDH6A1 KYAT3 HIBADH KMO OGDH FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA ACMSD TMLHE SHMT1 BBOX1 ALDH9A1 PNMT HAAO GRHPR DDC TDO2 TH IDO2 DBH IDO1 SLC25A44 MTRR DLST SLC44A1 GLDC HOGA1 OCA2 AMT TXNRD1 KYNU ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM OAZ3 AZIN2 AZIN1 AGMAT CKMT2 GAMT SMS GATM SLC6A7 GOT1 SLC6A8 CKM CKMT1B SLC6A11 CKB RPS27 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 DMGDH RPLP1 RPL34 CHDH RPL10L SARDH RPL8 ALDH7A1 RPL10A RPL6 RPL7 ARG2 ALDH4A1 PRODH SLC25A2 RPL7A RPL18A PRODH2 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 MTR RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MRI1 ENOPH1 BHMT2 BHMT OAT ADI1 GLS2 GOT2 PYCR1 MPST TSTD1 PYCR2 PYCR3 SQOR GLS GADL1 GLUD1 SUOX GLUD2 ADO KYAT1 CSAD RIMKLA TXN2 GLUL TST ETHE1 RIMKLB SLC25A10 CDO1 GSTZ1 ACADSB ACAD8 TYR SIRT5 DCT SEM1 TYRP1 GPT BCKDK BCKDHA BCKDHB DBT DLD SLC25A15 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) OPN1MW OPN1LW DHRS3 OPN1SW RBP3 AWAT2 RLBP1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle CS ISCA2 ISCA1 ACO2 FXN ACAT1 LYRM4 SDHAF2 SDHAF3 SDHAF1 CSKMT SDHAF4 IDH2 SDHC SDHD SIRT3 SDHA SDHB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation MAPKAPK3 MAP3K7 IRAK1 UBE2V1 MAPKAPK2 TRAF6 MAPK14 MAPK11 IRAK2 TAB1 TAB3 TAB2 NOD1 MAP2K6 NOD2 UBE2N IKBKG MAP2K3 RIPK2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs HACD1 ACSBG1 TECR HSD17B3 SLC27A3 HSD17B12 ACSBG2 HACD3 HACD2 HACD4 ELOVL1 ELOVL4 ACSL1 ELOVL5 ELOVL2 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER PCNA PARP1 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 DDB2 POLD2 POLE RFC2 RFC1 PARP2 RPA1 CHD1L RPA2 DDB1 XPA POLE4 CUL4A RPA3 RBX1 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 GCN1 RPS19 RPS18 EIF2AK4 RPS3 RPS2 RPS11 IMPACT RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 TRIB3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A CEBPB RPL6 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPL37 ATF3 ATF4 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking WNT5B WNT5A PORCN WNT7B WNT16 WNT1 WNT7A SNX3 WNT3A WNT9A WNT3 WNT8A WNT8B WNT10B WNT9B WNT6 WNT4 WNT2 WNT2B WNT10A VPS29 WNT11 VPS35 WLS VPS26A TMED5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB2 VDAC1 MAIP1 PARL AFG3L2 LETM1 SMDT1 YME1L1 PMPCB PMPCA MICU3 AKAP1 MICU2 MICU1 MCU PHB1 SLC8B1 SLC8A3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PDE6G GNB1 GNGT1 APOA2 APOA1 APOA4 HSPG2 APOE SDC4 SDC2 SDC3 LPL RBP4 RDH12 OPN1LW RBP1 LRAT LDLR AGRN STRA6 GPIHBP1 GPC1 APOC3 APOC2 RDH5 GPC3 RLBP1 LRP8 GPC2 GPC5 GPC4 GPC6 OPN1MW APOB RPE65 SDC1 CALM1 PRKCA RDH8 OPN1SW GUCY2D GUCA1B GUCA1A GUCA1C LRP1 GUCY2F NMT1 RETSAT GRK1 APOM GRK7 FNTB RHO BCO2 CNGA1 BCO1 GNAT1 RCVRN AKR1B10 CAMKMT CLPS RBP2 RGS9BP SLC24A1 SAG LRP10 NMT2 LRP12 RBP3 PPEF1 PNLIP HSD17B6 METAP1 METAP2 CNGB1 HSD17B1 FNTA AKR1C1 TTR RDH11 RDH10 ABCA4 AKR1C4 RDH16 AKR1C3 SDR9C7 DHRS3 MYO7A DHRS9 PRKCQ LRP2 PLB1 CYP4V2 AWAT2 PDE6B PDE6A CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CALM1 CAMK2G ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS PLA2G2D OSBPL10 PLA2G2E MBOAT1 PLA1A PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLAAT3 PLA2G2A OSBPL8 PLA2G1B OSBPL5 LPCAT4 LPCAT3 PLA2G2F PLA2G4A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS SOS1 HBEGF TGFA AREG EGF EGFR NRAS EREG BTC EPGN DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 MAP3K7 IRAK1 UBE2V1 TRAF6 MAPK9 IRAK2 TAB1 MAP2K7 MAPK10 MAPK8 TAB3 TAB2 NOD1 NOD2 UBE2N IKBKG RIPK2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 RUVBL1 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 POLR2A POLR2B POLR2C POLR2D NHP2 POLR2E POLR2F ANKRD28 POLR2G NOP10 POLR2H POLR2I POLR2J POLR2K PPP6C POLR2L PPP6R3 BLM RTEL1 CHTF8 DAXX ATRX WRN PRIM2 PRIM1 H2AX POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC2 TERT RFC1 H3-3B STN1 RPA1 TEN1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ RPA3 H2BC15 CCNA2 CCNA1 H2BC11 DNA2 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BRD7 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SMARCE1 ACTB ARID2 PBRM1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 BCL2L1 NLRP1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors PRKCA TSPAN7 AP2A1 GRIA1 GRIA2 PRKCB GRIP1 NSF PICK1 PRKCG GRIP2 GRIA3 GRIA4 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia F9 F10 F8 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 RPS6KA2 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle ARHGAP26 AKAP12 HINT2 VANGL1 ARHGAP32 PIK3R2 PIK3R1 RHOD ESYT1 ACTN1 LMNB1 TOR1AIP1 ARHGAP12 DBN1 CPNE8 STEAP3 ANKFY1 GOLGA8R MOSPD2 ADD3 ARHGAP1 SLC4A7 ARHGAP39 ARHGAP5 ARHGAP35 FILIP1 STBD1 EMD LBR TMPO VRK2 PLXNA1 LEMD3 DEPDC1B PLXNB1 CAPZB VAMP3 EFHD2 RAB7A ARHGAP17 ARHGAP21 PAK6 LMAN1 WHAMM PGRMC2 PAK5 RACGAP1 VAPB DIAPH1 DIAPH3 CAV1 MCAM CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway RELA MALT1 CASP8 NFKB1 IL1B PYCARD INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLST DLD SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function CDH24 ADAM33 ADAM19 CTNNB1 CDH11 JUP ANGPTL4 CTNND1 CDH8 CTNNA1 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance APOA1 HDLBP CUBN AMN MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase LMNB1 NCAPG2 SMC4 SMC2 NCAPH2 NCAPD3 MCPH1 NUP205 POM121 NUP107 NUP188 KMT5A AAAS NUP160 POM121C ARPP19 NUP42 NUP85 TPR ENSA NUP62 BANF1 NUP88 USO1 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB2A NUP155 NUP133 RB1 NUP210 VRK1 LEMD2 NUP153 NUP93 NUMA1 NUP50 NUP35 NUP54 RAB1A RAB1B GOLGA2 NUP37 BLZF1 PPP2R1B H2AX CNEP1R1 PPP2R1A H2AB1 MASTL H2AC19 GORASP2 H2BC26 GORASP1 H2AC14 PPP2R2D H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 MAPK1 PPP2CA PPP2CB LPIN1 LPIN2 LPIN3 NUP214 PRKCA PLK1 CCNB1 CDK1 SET EMD LEMD3 CCNB2 NEK9 NEK6 NEK7 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency OTC TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes PCNA PLK3 CDKN1A PRMT1 PLAGL1 NPM1 RGCC PLK2 CDK2 BTG2 CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 E2F4 CNOT9 CNOT11 E2F7 E2F8 RBL2 ZNF385A RBL1 SFN CCNB1 CDC25C CDKN1B AURKA ARID3A CDK1 BAX E2F1 CARM1 TFDP1 CCNE2 TFDP2 CCNE1 CPAP PCBP4 EP300 CNOT6L CCNA2 TP53 CCNA1 GADD45A CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CDC6 ORC5 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 UBE2W H2BC3 PEX14 H2BC1 USP7 HLA-B USP5 UBA1 RNF20 UBE2K CDC34 VCP UBE2J2 UBE2Q2 UBE2R2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA UBE2G1 UBE2G2 UBE2C CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS UBE2S WAC UBA52 PRKDC CTR9 RTF1 BCL10 UBE2Z TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 UBE2E3 PEX2 UBB UCHL3 UBC RPS27A UBE2T OTULIN UBA6 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP9X H2BC11 UBE2H UBE2B UBE2N RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 PAX5 ELF1 ELF2 CBFB BLK HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly APOA1 PRKACG A2M PRKACA PRKACB ABCA1 ZDHHC8 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 SOS1 PIK3R1 NRAS FGF20 MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 PPP2CA FGF18 PPP2CB FGF10 PTBP1 HNRNPM HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 BRAF UBB PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling SOS1 STAT5A STAT5B CBL PIK3R1 NRAS UBA52 CDKN1B GRAP2 PTPRJ CSK BCL2L11 FLT3 UBB PTPN11 UBC RPS27A AKT2 GRB10 HCK SYK HRAS LCK FYN SLA ABL2 SLA2 SOCS2 SOCS6 FOXO3 SH2B3 FLT3LG AKT1 GAB2 PIK3CA AKT3 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions HHIP BOC GAS1 SHH IHH DHH CDON PTCH1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle TRAK1 TRAK2 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol RXRA NCOA2 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 HSD3B7 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) LTC4S PTGR1 HPGD ALOX5AP ALOX12 ALOX5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 FCGR1BP PSMD13 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CD207 MRC2 ADRM1 PSME2 MRC1 PSMC5 PSMC6 SEM1 PSMC3 PSMB10 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 FCGR1A PSMD1 PSMB8 PSMB9 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing FURIN PCSK6 NGF PCSK5 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases ARSB ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD STS ARSA SUMF2 SUMF1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD GCLC GCLM PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PIP5K1C CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 DISEASE%REACTOME%R-HSA-1643685.19 Disease SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L SLC5A1 SLC5A2 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 RNF185 SLC26A3 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 EXOC1 GBF1 POMT2 CYP2U1 POMT1 CYP1B1 POMGNT1 B4GAT1 DAG1 LARGE1 FGFR2 OGG1 RAC1 VAV3 UBE2N VAV1 VAV2 CHST3 ACAT1 DCTN1 PTGES3 MAPK8 BCL2L11 DNAJA2 FKBP4 HSPA1B BAD IFNGR1 IFNGR2 B3GAT3 IKBKB SQSTM1 CYP27B1 MYD88 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FEN1 UBE2I SUMO1 UBE2D2 ELOB ELOC RBX1 VHL RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B TP53 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 ACTG1 PPP1CC PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DVL1 DVL2 DVL3 RPS27 ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CARS1 DYNLL1 RANGAP1 DYNLL2 EEF1G DCXR CHUK DYNC1I2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 TAOK1 TFG MPRIP FGFR1OP2 SND1 ZC3HAV1 EIF2AK3 NOX4 ATIC DUSP8 DUSP9 MRAS KDR FAM114A2 PORCN MCL1 QKI NF1 KIAA1549 DUSP10 ESRP1 BIRC6 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 AGTRAP AP3B1 SHOC2 AGGF1 NFKB2 CPSF6 SI TENT4A LCT SPRED3 CTDP1 SPRED2 ELL SPRED1 CCNT1 MYO18A SUPT4H1 ELOA LRRFIP1 NELFB KANK1 RRBP1 ETV6 WDCP NELFCD NELFA FAM131B GOLGA4 NELFE BIN2 STRN SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 LFNG JAG1 DLL1 SKP1 CUL1 NTRK3 NTF3 NEURL1B HES5 MIB2 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 RAF1 IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 JAK3 SIGMAR1 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 G6PC3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X RPS15 IGLV3-25 RPS14 IGLV3-27 IGKC RPS17 IGKV1-39 RPS15A RPS16 IGLV3-21 IGKV1-33 RPS19 RPS18 BRD4 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 RPS10 STAT2 RPS13 IGLC6 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 UBE2L6 RPS24 HERC5 RPS23 OGN NOTCH2 NOTCH3 NOTCH1 NOTCH4 HBEGF GCKR GCK HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E SFTPA2 RNF213 ATG7 SEC31A RPTOR CALR MLST8 EIF4E TSC2 MRC1 GRSF1 MTOR FKBP1A TLR6 AKT1S1 CYFIP1 NCKAP1 BRK1 PDIA3 S100A1 VPS36 CYBA VPS25 CBX1 SNF8 BCR CHMP1A LMO7 RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 NCKAP1L WASF1 PAK2 WASF2 CAV1 ERBIN BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 TGFB1 TGFBR1 TGFBR2 LMNB1 TIRAP SEC23A B3GALT6 B4GALT7 WIPF1 WIPF2 WIPF3 FCGR1A SEC24B SEC24A IQGAP1 MAP3K11 SEC24D SEC24C DUSP16 FGFR1 TMPRSS2 WASL SRPK2 GALNT1 AXL TCN2 CD320 RCC1 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 TPST2 TPST1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B MASP1 XRCC6 XRCC4 XRCC5 LIG4 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A ACAN RPL36AL LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 HDAC4 RPL27 HDAC2 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 AMER1 RPL35A RPL23A GSK3B CSNK1A1 RPL3L AXIN1 RPL27A RPL22L1 APC RPL26L1 OPN1SW ENO1 CDC73 SKIC8 CTR9 RTF1 ALDOB LEO1 PAF1 HHAT SHH PGK1 DHH MAP2K4 CGAS CREBBP IRAK4 SP1 KHK TLR10 TLR5 AREG NFE2L2 BCL2L1 PTPN6 MAPK9 IRAK2 MAP2K7 CAMK4 NTF4 NTRK2 BDNF TAB3 TGFA TAB2 NFKBIB FOXO3 ELK1 PTK2 IFNA5 EREG IFNA4 BTC IFNA7 MC2R EPGN IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 KCNJ11 ARIH1 ABCC8 IFNA13 ABCC9 IFNA14 ADCY9 IFNA16 IFNA17 ADCY4 BAG2 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 FGR GGT5 GSS OPLAH GCLC ITPR1 ITPR2 GGT1 ITPR3 GCLM NOS2 P2RX7 EML4 P2RX4 GNAS VPS33B CORO1A HGS RAB5A KPNB1 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 UPK1A EPCAM FDXR SLC6A19 SLC36A2 SLC6A14 FDX1 FDX2 SLC7A7 SLC7A9 DUSP6 DUSP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B CYP21A2 STT3A STT3B MAN1B1 ECHS1 RETREG1 KEAP1 H2AC17 AGK H2AC12 TRIM25 CFTR STAM CYP4F22 CYP19A1 H2AC25 H2AC21 WDR48 IFIH1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TBXAS1 KAT2B PIK3CD KAT2A RNF135 TAF9B SFTPC MAP3K7 GBE1 GYS2 H2AC1 CDC25A GYG2 EPM2A STAM2 PPP1R3C VCP NHLRC1 CLINT1 TNKS FOXO4 GALT CYP27A1 NLRP3 RIPK1 SUDS3 SMAD2 SMAD4 SMAD3 ESR1 NFKBIA SCAP MAVS MDM2 TAB1 RIGI PTEN ARRB1 ARRB2 TRAF2 MERTK H2BC18 TRAF3 TRAF6 BECN1 CYP7B1 NOD1 NOD2 TNKS2 TAF10 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 AQR CRNKL1 DPEP2 CDC40 DPEP1 DHX9 CSTF3 CYP11A1 CSTF2 PCBP1 PCBP2 CSTF1 CYP11B2 DHX38 SYMPK RBM10 HNRNPL HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 IRF4 PRPF6 BCL2A1 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CPSF4 CPSF1 FUS ALYREF CPSF3 CCR5 CPSF2 CXCR4 CWC15 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 SLC35D1 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC27A4 KIT RBPJ B4GALT1 TXNIP SFN EZH2 CLDN1 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 PMS2 RICTOR MBD3 STAT1 GATAD2B GATAD2A CCNT2 CDC25C MSH2 KMT2D FOXO6 FOXO1 MED30 MED31 G6PC1 NFKB1 SFTPB SFTA3 SFTPA1 FASLG ITGA4 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A CCNK MUC5AC MUC3B CCNC ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 SH3GL3 EPS15 SH3GL2 SH3GL1 YES1 EEF2 CTSL SYVN1 RELA FZD8 ARPC1B ARPC1A NPM1 ITCH KLC1 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH ACTR3 ACTR2 NR3C1 TRAK1 KIF5B IRAK1 NCKIPSD ACY1 IL6 TAF4B YWHAE PRR5 DPY30 CHD4 PPM1K YWHAQ AUH IVD YWHAG HIBCH C4A YWHAH TBP EED GALM TAF9 TAF1L MTA2 TAF15 TAF12 TAF13 TAF11 SOD2 REST TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 MAML2 MAML1 DNAJC3 JUNB MED1 GALK1 MED8 GALE MED4 MED6 MED7 MAML3 MAPKAP1 NEDD4L PRDX2 PRDX1 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 PLK2 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 CD19 V2-8 V1-20 ASH2L V1-9 TAF7L V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QA C1S V4-6 V4-2 V4-1 ISCU SNAP25 SYT1 MSH3 PTPN12 NRBP1 TLR8 PAH KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ABL1 GNS CDK8 CDK5 WDR5 PYCARD CLEC5A GYG1 HDAC5 RAB5B RAB5C HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 RBBP5 RBBP7 TXNRD1 PML PGM1 HDAC10 TTR HDAC11 FCGR2A TWIST1 TXN PARP1 BST2 PRMT1 GP1BA HBB CD33 MLH1 TJP1 GAA CDK5R1 ESR2 NR4A1 CASP1 CD300A THBS1 ERBB2 HES1 DDX3X POMC PHB1 ARAF PEBP1 CSK JAK2 MARK3 HGSNAT FGB DYNLT1 BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 GALNS SLC9A6 SLC9A9 HCK SYK LCK UGT1A4 FYN F9 F10 GGCX PROS1 F2 GAS6 UGT1A1 BCKDK BCKDHA BCKDHB DBT DLD CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 CUBN AMN APOA1 SAR1B AP2S1 AP2B1 P4HB PRF1 ICOS STAT5A IL10RA ZC3HC1 CD3G BTRC ADAMTS13 MTA1 MTA3 FCGR3A MYH2 MYO10 MYO1C APRT PNP HPRT1 ADA PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX FZD5 FZD4 FZD6 PIM1 GBP2 GBP4 IKBKE IRF7 GP1BB F12 F11 GP5 GP9 KLKB1 BAG4 RAN SLC20A2 NEK2 WNT3A LRP5 KREMEN1 TUBB KREMEN2 DKK1 DKK2 LRP6 DKK4 AKAP9 ABCA4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 SUGT1 IGF1R CALM3 CALM2 CEP43 KDM7A ATP1B3 ATP1B2 ATP1B1 RBP4 RDH12 OPN1LW RBP1 NAPEPLD LRAT STRA6 FXYD4 MMAB FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 MTRR ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ANO10 CLCN6 SUN2 CBLIF MMACHC MMADHC NRG3 NRG4 NRG2 NTHL1 NEIL3 NEIL1 PIK3AP1 SIKE1 CSF2RB CSF2RA CD36 STAT5B GRB2 ARID4B CTBP2 CTBP1 SAP30 DNMT1 NCL CEBPD PDGFRB DNMT3B DNMT3A SAP30L RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 PARP9 IL17F IL17A PARP14 PARP8 GEMIN2 TUFM GEMIN4 CRK GEMIN5 GEMIN6 FMO3 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 FADD P4HA3 CD14 GSDMD DNAJC10 NMT1 GSDME C1QBP MAT1A RIPK3 IL18 IL1A IL1B TLR4 BCAP31 AHCY FNTA TICAM1 CHMP4C CHMP4B CHMP4A LY96 MLKL MAOA CHMP2B CHMP2A TRADD HMGB1 CASP8 CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 PAPSS2 PAPSS1 SDC4 SDC2 SDC3 SGSH NAGLU GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 SLC5A5 LYN PIK3CG PIK3R6 PIK3R5 BTK ARF1 NPLOC4 RPLP0 JAK1 IL10 MSN TALDO1 TYK2 PPIA ALK AHCYL1 LMNA KPNA2 MMAA MMUT MCCC2 BTD PC PCCA HLCS MCCC1 PCCB SPCS3 SPCS2 SPCS1 SEC11A SEC11C FOXM1 GNAZ CD163 RHBDF2 ADORA2B JAG2 ADAM17 RDH5 RLBP1 CYFIP2 GJA1 ZMYM2 FGFR3 GYS1 TPM4 TPM3 RNF43 KLB FLT3 IRS1 IRS2 EIF4E3 PIK3CB PPM1B FGF1 FGF2 FGF3 EIF4G3 FGF4 EIF4G2 FGF6 NCK1 FGF7 FGF9 AKT2 HRAS WASF3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 TLR9 PIK3C3 SOS1 RAC2 SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 NRAS FGF20 PPFIBP1 ATP6V1H MAPK1 FGF23 FGF22 ELMO2 MAPK3 PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 UNC93B1 TLR3 ABCA3 CAMK2B CAMK2D SRC CAMK2A NRG1 MTR ZAP70 CALM1 DOCK2 CAMK2G ANAPC15 DOCK1 ANAPC16 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CCNB1 CDC23 TRAT1 UBE2S RPS6KB2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 CYP11B1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 APP RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 HGF RAD9B RHNO1 ATR RAD9A CLIP1 SLC25A15 CPS1 ARG1 ASL NAGS KDELR1 SERPING1 ASS1 GCC2 NMRAL1 OTC PDGFB CLU HSPA5 CTSG COG1 TLR1 S100A9 S100A8 LTF TLR2 F8 CD9 S1PR1 GOLGA2 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST PRIM2 CUX1 CD4 PRIM1 POLA1 POLA2 ACACA TRIP11 PDGFRA GTF2A1 CHSY1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN TCF7L2 CDKN1A HDAC1 CDKN2A CDC25B CCND1 SIN3A CDK2 CTNNB1 MET CEBPB TNRC6C MOV10 ACOT2 STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 GRPEL1 YWHAB ELAVL1 PSMD8 HMOX1 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 IDH1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 PEX19 SRD5A3 C3 FURIN SLC67A1 CPSF7 ROCK1 ROCK2 CUL3 SRRM1 VIM HNRNPC RBMX AP1G1 ZBP1 AP1S2 AP1S1 AP1S3 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 HLA-A CD8B PACS1 IDUA ELMO1 NCAN CD28 HEXB OPN1MW HEXA BGN PALS1 DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB UVRAG MAP1LC3B TRIM27 HSP90AA1 EGF CBL EGFR CYP17A1 CDC37 PLCG1 CDKN1C RB1 CDKN1B CCND3 FZR1 FNTB CCND2 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 NMT2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX LIG1 MSH6 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 SFPQ IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 TAL1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ABCA1 ABCG8 ABCG5 NCOR2 NCOR1 TBL1XR1 DPAGT1 ST6GALNAC2 MPI HK1 GNAI3 GNAI1 GNAI2 ALG8 ST6GAL1 ALG9 ALG6 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 DHDDS DPM1 DPM2 DPM3 RFT1 ST6GALNAC3 ST6GALNAC4 SLC24A1 GNE NEU1 ST3GAL4 SLC17A5 ST3GAL1 AVP ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 SLC4A1 PMM2 ABCA12 SLC4A4 BSG GFPT1 SLC12A6 DOLK SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling TYK2 CANX IL6ST STAT4 JAK2 IL27RA EBI3 STAT3 IL12A JAK1 IL12RB2 STAT1 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions SLCO4A1 SLCO1A2 SLCO2B1 SLCO4C1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 AVP SLCO2A1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling JUN RELA RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 VAV3 PPP3CA PPP3CB PRKCQ PPP3R1 VAV1 UBE2N VAV2 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 NFATC2 V1-11 V1-16 V1-13 MAPK8 IKBKB V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 PSMD14 NFATC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 PSMC3 AHCYL1 PSMC4 PSMC1 PSMC2 PAK2 RASGRP4 MAP3K7 CARD11 MALT1 NFKBIA TAB1 TEC TRAF6 PLCG1 PIK3CB HRAS PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 NFKB1 NRAS MAPK1 CHUK FCER1G MAPK3 CALM1 UBE2D1 FCER1A LAT2 BCL10 MS4A2 TXK MAP2K4 FBXW11 MAPK9 SYK MAP2K7 SEM1 MAP3K1 FYN MAPK10 TAB3 SKP1 TAB2 FOS CUL1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NEDD4L TGIF1 UBE2D1 TGIF2 TRIM33 PARP1 HDAC1 UBA52 MAPK1 SKIL MAPK3 UBB ATP1B4 SKI UBC SMAD2 NCOR2 RPS27A SMAD4 SMAD3 NCOR1 SMURF2 SMAD7 SNW1 RNF111 WWTR1 PPM1A UBE2D3 USP9X RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF RUNX1 CCND1 BRD2 RUNX3 EP300 KRAS HDAC4 CBFB TGFB1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response MYH9 CD163 RHBDF2 FURIN ADAM17 IL10 MAPK14 PLK2 IL6 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle TFRC KIF14 KIDINS220 VANGL1 MUC13 PIK3R2 ARHGAP5 TMEM59 PIK3R1 ARHGAP35 TXNL1 ALDH3A2 PKP4 RASAL2 STIP1 PLXNA1 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 STMN2 EPSTI1 PTPN13 RND1 PLEKHG5 FRS2 FAM135A GRB7 VANGL2 FLOT2 DSP CAV1 RRAS2 CCDC88A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere H2BC9 ACD H2AZ2 TINF2 POLR2A H4C9 TERF1 POLR2B H2BC8 TERF2 POLR2C H2BC5 POLR2D H2BC3 POLR2E H3-4 POLR2F H2BC1 POLR2G POT1 POLR2H TERF2IP POLR2I POLR2J H2AC20 POLR2K POLR2L DAXX ATRX H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle CUL3 PLIN3 RAB9A RAB9B HGS VHL CCNE1 RHOBTB3 LRRC41 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLRMT POLG2 RNASEH1 TOP3A POLG TWNK MGME1 EXOG SSBP1 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance ALDOB COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 COL17A1 ITGB4 COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 PLEC COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 LOX COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 CTSS PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB LAMB3 P4HA1 LAMA3 P4HA2 P4HA3 LAMC2 COL1A1 COL1A2 ADAMTS14 MMP9 P3H2 P3H1 P3H3 PXDN MMP3 SERPINH1 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis GGPS1 LSS SQLE IDI2 ACAT2 MVD IDI1 MVK PMVK FDFT1 FDPS PLPP6 HMGCS1 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome TAF7L CCNT2 TAF4B ELOB ELOC RNMT CCNH POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L RNGTT GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 SUPT5H GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 TAF10 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 CD8B ATP6V1H TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion TRIT1 YRDC TRMU TRMT61B OSGEPL1 GTPBP3 TRMT10C MTO1 PRORP HSD17B10 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 POMT2 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs RBM8A ISL1 ETF1 GSPT2 GSPT1 UPF3A USP33 UPF2 LDB1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH HOXA2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 ZSWIM8 RPL34 MSI1 RPL10L RPL8 RPL10A RPL6 RPL7 LHX3 RPL7A RPL18A RPL36AL LHX2 RPL36 LHX4 RPLP2 RPL35 LHX9 RPL38 RPL37 COL4A5 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A ROBO2 RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CASC3 PSMB4 PSMB5 UBB PSMB2 PSMB3 NCBP1 SLIT1 UBC NCBP2 PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 BTK CFL1 ACTB MYO5A SYK PAK1 NCKAP1L WASF1 PTK2 WASF2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion PPIA CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA RELA XRCC6 XRCC5 NFKB1 DHX9 CTNNB1 CHUK IKBKB RIPK1 MYD88 ZBP1 TLR3 TREX1 DDX41 DTX4 TBK1 IRF3 NFKBIA STING1 NLRP4 TRIM32 TRIM21 TRIM56 IRF7 NLRC3 IFI16 CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F UBA52 POLR3G PRKDC DHX36 POLR3H POLR2K POLR2L POLR3K MRE11 NFKB2 RIPK3 NKIRAS1 LRRFIP1 NKIRAS2 IKBKG UBB CGAS AIM2 CREBBP UBC TICAM1 RPS27A EP300 STAT6 NFKBIB POLR1C POLR1D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways RELA MAP3K7 NFKB1 HSP90AB1 ITCH PANX1 CHUK MAP2K6 NLRP3 IKBKB IRAK1 CARD9 TAB1 TXNIP HMOX1 TNFAIP3 MAPK12 MAPK13 CASP1 CASP2 P2RX7 PYCARD TRAF6 BIRC2 BIRC3 NLRC4 CYLD NFKB2 NOD1 NOD2 IKBKG NLRP1 RIPK2 AIM2 BCL2 UBE2V1 BCL2L1 AAMP MAPK14 IRAK2 MAPK11 APP MEFV PSTPIP1 TAB3 TAB2 SUGT1 CASP8 TXN CASP4 CASP9 UBE2N BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport KIF28P KDELR1 KDELR3 KIF5C KIF21A KIF21B KIFAP3 KLC1 KLC4 KLC3 KLC2 RINT1 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 KIF3B SEC22B KIF3C RAB6B KIF5B KIF5A KIF18B KIF4B KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 BICD2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 PAFAH1B3 ARF5 NAPA GBF1 NAPB NBAS RAB6A RAB1A STX18 RAB1B NAPG GALNT1 BNIP1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 GALNT2 ARCN1 ZW10 KIF26A KIF26B RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 ACTR1A ARF1 DCTN2 CAPZA1 DCTN3 RACGAP1 ARFGAP1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 TUBB2B TUBB2A TCP1 CCT6B TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 UBC TICAM1 RPS27A TLR3 TBK1 IRF3 TRAF3 OPTN UBA52 IKBKE IRF7 TANK UBB ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP CHTF8 PRIM2 PRIM1 POLA1 DSCC1 POLA2 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 CHTF18 RFC2 RFC1 STN1 TEN1 CTC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis MAPK1 CTSG TRIM27 SFPQ RNF213 GSK3A MAPK3 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CREBBP BHLHE40 RBM4 DBP TFEB CRY2 CRY1 CIPC PER2 PER1 RORC PER3 RORA NR1D1 BMAL1 CRTC1 KMT2A SIK1 CLOCK NPAS2 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R4 GNG13 KCNJ2 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 SCNN1G SCNN1D SCNN1B SCNN1A TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 OTOP1 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis CHST15 CSPG4 CHST3 CHPF NCAN CHSY1 CHST11 BGN CHST12 CHSY3 DCN CHST13 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 UST CSPG5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs MON1A TRAPPC6A MON1B DENND1C TRAPPC6B DENND1B GDI1 DENND1A ULK1 RAB8B DENND2D TRAPPC10 RAB14 DENND2C DENND2B DENND2A RAB3IL1 GDI2 RAB7B DENND3 RAB21 ALS2CL RAB27B CHML RAB12 RAB13 TRAPPC4 CHM RAB9A RAB6B RAB9B RAB39A YWHAE AKT1 ALS2 RAB3A RAB31 RAB5B RAB5C RAB3IP RAB6A RAB1A RAB1B TRAPPC1 RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 GAPVD1 RAB7A RIC1 RAB32 RAB35 RGP1 RAB27A RAB38 AKT2 DENND6B RIN3 RAB3GAP2 RAB8A TRAPPC2L DENND6A RAB10 RIN1 RIN2 RAB3GAP1 RAB18 TRAPPC2 TRAPPC3 ANKRD27 DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B AKT3 TRAPPC8 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling TNFSF10 TNFRSF10B TNFRSF10A CASP10 CASP8 TNFRSF10D FADD CFLAR INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling TYK2 IL6ST JAK2 STAT3 CBL JAK1 SOCS3 IL6R STAT1 PTPN11 IL6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network SCOC SYS1 GCC2 GCC1 RAB43 GOLGA1 ARFIP2 RHOBTB3 COG8 COG7 COG6 NSF COG5 COG4 COG3 COG2 COG1 ARL1 VTI1A PLIN3 RAB9A RAB6B RAB9B RABEPK M6PR NAA30 IGF2R NAA35 NAA38 VAMP4 NAPA NAPB TGOLN2 TMF1 STX16 RAB6A NAPG STX10 ARFRP1 VPS51 GOLGA4 VPS53 VPS52 STX6 VPS54 VAMP3 RIC1 RGP1 USP6NL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY2 LEFTY1 SMAD4 SMAD3 CRIPTO3 FURIN DAND5 PCSK6 CFC1 CER1 NODAL GDF1 CRIPTO MAPK1 FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C FOXO3 MAPK3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MT1G MT1H MT1X MT4 MT1B MT3 MTF1 MT1E CSRP1 SNCB MT2A MT1A MT1M MT1F DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines SAT1 PAOX PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 POLE FEN1 RFC2 RFC1 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 APEX1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis ARV1 GGPS1 CYP51A1 LSS SREBF2 SQLE DHCR7 IDI2 ACAT2 MVD EBP LBR HSD17B7 DHCR24 PLPP6 NSDHL MSMO1 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC6A20 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling IFNA2 ADAR IRF1 IRF2 IFNA8 XAF1 IFNA13 HLA-H IFNA14 IFNA16 IFNA17 HLA-B BST2 HLA-C HLA-F HLA-G HLA-E OAS2 IFITM3 IFITM2 IFNA10 IFIT5 IFI35 IFNA21 IFIT3 IFNB1 IFIT2 EIF2AK2 ISG15 RSAD2 IFI27 STAT1 SOCS1 PTPN1 IP6K2 PTPN11 EGR1 IFI6 IFITM1 ISG20 IRF8 IRF6 IRF3 IRF9 IFNAR1 SAMHD1 HLA-A GBP2 IRF7 PSMB8 ABCE1 KPNA1 UBA52 OASL OAS1 OAS3 RNASEL JAK1 KPNB1 USP18 UBB IFIT1 UBC TYK2 MX2 RPS27A MX1 STAT2 SOCS3 PTPN6 IRF4 IRF5 IFNA5 IFNA4 IFNA7 IFNA6 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ACE2 FURIN ANO1 TMPRSS2 ANO10 ANO8 ANO9 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib ERBIN HSP90AA1 ERBB2 CDC37 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT SLC24A1 RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL3 PSMA7 PSMB6 PSMB7 HECW1 KLHL12 PSMB4 PSMB5 DACT1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 DVL1 PSMC4 PSMD8 DVL2 PSMC1 PSMD6 DVL3 PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis TYRP1 SLC45A2 TYR OCA2 DCT SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants FLT3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN APH1A FGD1 PSENEN FGD2 GNA13 NCSTN FGD3 APH1B PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ITGB3BP ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 SQSTM1 YWHAE CASP2 TRAF6 UBA52 BEX3 UBB UBC RPS27A TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 CASP3 TIAM2 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G2D PLA2G2E PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 PLAAT3 PLA2G2A LPCAT1 PLA2G4A PNPLA8 PLA2G4F PLA2G12A TMEM86B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 PLB1 LPCAT3 PLBD1 LPCAT2 PLA2G2F MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation YAP1 GLI3 HEY1 HES1 BGLAP HEY2 ABL1 RB1 WWTR1 SRC YES1 MAF HDAC3 COL1A1 SATB2 MAPK1 HDAC6 SP7 UCMA MAPK3 CBFB ZNF521 AR CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins EPB41L3 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 EPB41L1 STX1A SHARPIN SYT9 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 CASK NRXN2 GRIN2A LIN7A DLG2 LIN7C DLG3 LIN7B DLG4 PDLIM5 NLGN4Y NLGN4X SYT10 SYT12 APBA1 SYT1 DBNL GRM1 GRM5 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 FGF18 FGF1 FGF2 FGF4 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs CDC42 RAC1 IQGAP1 IQGAP2 IQGAP3 CTNNB1 CDH1 MEN1 CALM1 CLIP1 CTNNA1 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling CLTC CLTB TIAM1 CLTA AP2A1 AP2A2 ARHGEF7 ARPC1B NGEF ARPC1A AP2M1 RHOA KALRN APH1A PSENEN ROCK1 NCSTN ROCK2 APH1B PSEN2 CLTCL1 ARPC4 ADAM10 ARPC5 PSEN1 ARPC2 ARPC3 DNM1 ACTR3 ACTR2 ARHGEF28 SDC2 CDC42 AP2S1 AP2B1 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 GRIN2B EPHA1 EPHA3 GRIN1 MYL9 EPHA10 EPHB6 EFNB2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 EFNA5 EFNA4 CFL1 GIT1 EFNA1 EFNA3 WASL EFNA2 ACTG1 MMP9 ACTB MMP2 NCK2 EPHA2 ITSN1 RASA1 SDCBP YES1 PAK1 PAK3 LIMK2 RAC1 HRAS LIMK1 MYL12B FYN VAV3 MYL6 MYH9 MYL12A MYH14 MYH11 MYH10 PAK2 PTK2 VAV2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE5A MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 SLC35A1 CHST10 DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A4 FKRP CRPPA POMGNT1 B4GAT1 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs ALK HIP1 PRKAR1A CLTC STRN PPM1B BIRC6 NPM1 EML4 FN1 EIF2AK3 BCL11A SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) TIAM1 SOS1 FRS3 CDK5 NTF3 PIK3R1 NRAS PLCG1 SRC DOCK3 RAC1 HRAS GRIN2B NTF4 NTRK2 BDNF GAB1 FRS2 PIK3CA CDK5R1 PTPN11 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CB JAK2 PIK3CD LYN GAB1 PIK3R1 PIK3CG PIK3CA PIK3R5 EPO EPOR IRS2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS HRAS RAPGEF1 SOS1 JAK2 SHC1 LYN NRAS CRKL EPO VAV1 EPOR IRS2 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases UBC GYG1 RPS27A SLC37A4 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 EPM2A PPP1R3C NHLRC1 GAA G6PC3 UBB GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism GCKR GCK PPP2R5D G6PC1 PC PRKACG PRKACA PRKACB PCK1 PPP2CA PPP2CB SLC37A4 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK2 PGK1 SLC37A1 NUP37 PGK2 G6PC2 PFKL G6PC3 FBP1 GNPDA1 FBP2 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP CITED2 ARNT CA9 HIGD1A VEGFA EPAS1 EP300 HIF1A EPO ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MRAS PPP2R5B PPP2R5A PPP2R5D PPP2R5C NRAS PHB1 MAP3K11 ARAF SHOC2 RAF1 JAK2 MARK3 BRAP KSR1 PPP1CB PPP1CC BRAF PPP2R1B PPP2R1A PPP2CA PPP2CB CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS MAP2K1 MAP2K2 CALM1 CAMK2G PPP2R5E ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism CYP4B1 FAAH DPEP2 DPEP1 ALOX15 LTA4H PTGES3 PTGDS CYP4F3 CYP4F8 CYP2J2 PRXL2B PLA2G4A GGT5 PTGES PTGR1 CYP4A22 PTGR2 GGT1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 ALOX15B LTC4S PON3 HPGD PON2 PON1 EPHX2 GPX2 HPGDS ALOX5AP MAPKAPK2 CBR1 CYP4F22 CYP2C9 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 CYP4F11 SLC27A1 TBXAS1 PTGES2 ALOX12 GPX1 GPX4 CYP8B1 FAAH2 AKR1C3 AWAT1 ALOXE3 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 MAPK1 MAPK8 IFNB1 MAP3K5 MAP2K6 MINK1 MAPK3 TNRC6C TNIK MOV10 BMI1 AGO3 CBX6 AGO4 RING1 MAP4K4 AGO1 MDM2 TNRC6A MDM4 TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 EED CDKN2D CDKN2C MAPKAPK2 UBA52 CDKN2B E2F1 RBBP4 E2F2 MAPKAPK5 E2F3 EZH2 CDK6 TFDP1 RBBP7 TFDP2 CDK4 H2AX MAP2K3 UBB MAP2K4 H2AB1 MAPKAPK3 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 MAPK9 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 H2BC17 MAP2K7 H2BC12 H2BC13 MAPK10 H2BC14 H2AJ H2BC15 FOS TP53 H2BC11 TXN KDM6B H3C15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors APOA1 SSC5D S100A9 PRDX1 CD5L APOB CD36 SAA1 HMGB1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin TPGS1 TPGS2 TUBB8 AGBL5 AGBL4 AGBL1 AGBL3 TUBA1C AGBL2 TUBA1B TUBB8B TUBA1A LRRC49 VASH2 VASH1 TUBB2B TUBB2A TTLL7 TTLL6 TTLL5 TTL TTLL4 TUBB6 TTLL3 TUBB3 TTLL2 TUBA3E TUBB1 TTLL1 SVBP TTLL9 TTLL8 TUBA3D AGTPBP1 TUBA3C TTLL10 NICN1 TTLL13 TTLL11 TTLL12 TUBB4B TUBB4A DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions CLEC5A SOS1 SIGLEC14 PIK3R2 PIK3R1 HLA-B KLRK1 HLA-C KIR3DS1 NRAS PLCG1 BTK HLA-E GRAP2 NCR2 KIR2DS2 SIRPB1 KIR2DS4 KIR2DS5 CD300LB TREM1 SIGLEC16 SIGLEC15 CD300E LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 PRIM2 PRIM1 POLA1 H2AX POLA2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L POLE H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 CDC45 KPNA6 MCM10 DBF4 RPA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors STAB1 APOB SPARC STAB2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCB6 ABCB4 SEL1L KCNJ11 ABCC8 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 ABCD4 VCP ABCC2 ABCA1 ABCG8 ABCC6 ABCG5 LMBRD1 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 ABCA3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ABCA12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora EPM2A UBC GYG1 RPS27A PPP1R3C NHLRC1 UBA52 GYS1 UBB THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism SDS SDSL RIDA P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway HLA-H CTSV B2M HLA-B CTSL HLA-C CTSS HLA-A HLA-F HLA-G HLA-E LNPEP GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TOPORS SUMO2 UBE2I SUMO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling CBL UBA52 FGF20 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF7 FGF9 MKNK1 SPRY2 FRS2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence RPS6KA1 JUN CXCL8 RELA HMGA2 H1-1 H1-0 H1-3 LMNB1 IFNB1 CABIN1 H1-2 MAP2K6 H1-5 H1-4 HIRA UBN1 EP400 ASF1A MDM2 MDM4 IL6 EED CDKN2D CDKN2C RB1 HMGA1 CDKN1B FZR1 E2F1 IGFBP7 RBBP4 E2F2 MAPKAPK5 E2F3 CDK6 IL1A TFDP1 RBBP7 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TXN KDM6B H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 VENTX TERF2 H2BC8 H2BC5 H2BC3 MAPK7 STAT3 H3-4 H2BC1 NFKB1 CDKN1A POT1 TERF2IP H2AC20 CDKN2A MAPK1 CDK2 MAPK8 MAP3K5 CEBPB MINK1 MAPK3 ETS1 ETS2 EHMT2 EHMT1 ERF TNRC6C TNIK MOV10 ID1 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 MAP4K4 TNRC6A TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 MAPKAPK2 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 EZH2 KAT5 NBN MAP2K3 UBB MAP2K4 MAPKAPK3 UBC SP1 RPS27A MAPK9 MAPK14 MAPK11 MAP2K7 RAD50 MAPK10 TP53 FOS CCNA2 ATM CCNA1 RPS6KA3 RPS6KA2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease HRAS SOS1 FGFR4 GAB1 FRS2 PIK3R1 NRAS PIK3CA PLCG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 PRDX1 RELA MAFG PGD NFKB1 ABCG2 NQO1 CDKN2A GSTA3 GSTA1 SRXN1 CHD6 CCL2 ABCF2 PRKAA2 SOD3 G6PD SQSTM1 ATF4 GCLC TKT ABCC3 MYC ABCC1 GCLM PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B IDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF PSMA2 UBA52 PSMD12 PSMD11 ME1 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 BACH1 UBB TXNRD1 PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 PSMB1 BCL2 PDGFA RPS27A MAFK SLC7A11 AREG NFE2L2 BCL2L1 EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TXN NOTCH1 CUL1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane MTMR3 MTMR8 MTMR9 RAB14 PIK3R2 MTMR6 PIK3R1 PIP5K1A PIP5K1B MTMR14 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B INPP5J INPP5K PI4K2A PTEN MTMR1 PIP5K1C INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RAB4A RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 INPPL1 RUFY1 PIK3CA PIK3R3 SBF2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate CHIA AMY2A AMY1A MGAM AMY2B TREH AMY1B SI AMY1C LCT CHIT1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) GP5 SERPINA5 GP9 SERPING1 KLKB1 CD177 THBD GP1BA KNG1 C1QBP FGB F3 FGA VWF FGG PF4 F2R A2M PRCP TFPI F13B PRTN3 SERPINC1 F7 F13A1 F9 PROC F10 SERPIND1 F5 PROS1 PF4V1 F8 F2 SERPINE2 GP1BB F12 F11 PROCR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination SRSF6 CLP1 SRSF7 MAGOH ZNF473 SNRPD3 SNRPB SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF7 CPSF1 ALYREF DDX39B CPSF3 CSTF3 CSTF2 CPSF2 SRRM1 CSTF1 DHX38 SYMPK UPF3B MAGOHB RNPS1 PCF11 WDR33 LUZP4 POLDIP3 SRSF1 SLU7 CSTF2T U2AF1 FYTTD1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SRSF11 NUDT21 CASC3 PAPOLA LSM10 NCBP1 LSM11 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SNRPG SRSF2 SRSF3 SNRPE EIF4A3 SRSF4 SNRPF SRSF5 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 SLIT1 SLIT3 DCC NTN1 NELL2 SLIT2 ROBO1 SRC DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling AIP ARNT2 PTGES3 ARNT AHRR HSP90AB1 AHR STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 RAF1 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 TRPM1 SRI TRPM2 TRPM7 TRPM8 TRPM5 WNK1 TRPM6 TRPM3 WNK2 TRPM4 WNK3 TRPC7 TRPC5 MCOLN3 TRPC6 RYR1 TRPA1 RYR2 TRPC3 RYR3 TRPC4 UNC80 TRPC1 TRPV2 TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 STOM NEDD4L SGK1 CALM1 UBA52 WWP1 UBB UBC RPS27A OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System SEL1L ERLIN1 ERLIN2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 UBE2V2 RAC1 VAV3 COPS5 UBE2N VAV1 VAV2 ADAR SOS2 DCTN6 DCTN5 DCTN1 DCTN4 HSPA1L HSPA2 CAPZA3 MAPK8 BCL2L11 CAPZA2 ACTR10 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 UBE2I SUMO1 UBE2D2 UBE2D3 ELOB ELOC RBX1 EPAS1 CUL2 HIF1A VHL POLR2E POLR2F POLR2H POLR2K POLR2L KRT1 ACTB FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B TP53 FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 SPHK1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 TCP1 BTNL2 XDH MT2A CCT8 TUBB4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 DSC1 NUP50 NUP35 NUP54 NUP37 ACTG1 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DSN1 DIAPH1 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 RHOA KIF2A BIRC5 EVL KIF2C KIF2B CHUK DYNC1I2 IP6K2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE EIF2AK3 CENPS CRCP MCL1 POLR3GL POLR3A POLR3B VEGFA POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IL22 NFKB2 CD274 IL2RG LRRFIP1 FCN2 BIN2 FCN3 CRP COLEC10 SKP1 CUL1 SLC15A4 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 CA1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 PRKRA IGKV4-1 TARBP2 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM LAMA5 SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 BRWD1 IGLC3 BLNK IGLC1 VTN IGLC2 JAK3 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 BRD4 IGLC7 IGHV3-53 IGKV5-2 STAT2 IGLC6 IGKV1-5 IMPDH1 IMPDH2 PDCD1 LIMK1 EEF1A1 MYH9 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 IL23R FBXO9 IL13RA2 IL13RA1 HLA-H IL4R WSB1 FBXO2 IL23A HLA-B FSCN1 HLA-C NDN ATG14 LIF NANOG HLA-F IGHE HLA-G HSP90AB1 HLA-E OPRD1 OSM RNF126 CDC34 BATF HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 PRKAA1 ATG7 PRKAA2 CAB39 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 CD207 CALR FBXL4 MLST8 DZIP3 RNF220 EIF4E DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 MTOR LRRC41 VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 LAMTOR2 UBE2G2 LAMTOR1 PSMB8 PSMB9 LAMTOR3 KLHL9 SPSB2 CYFIP1 NCKAP1 SPSB1 KBTBD6 NCF1 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 BRK1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z STBD1 FBXO22 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 RAPGEF1 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 RAB7A TRAIP RNF41 KLHL42 UBE2V1 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 ABL2 FBXO40 NCKAP1L BTBD1 LONRF1 WASF1 UBE2F PAK2 RAG2 UBE2H RAG1 KLHL25 WASF2 UBE2B IL32 ZBTB16 RASGRP4 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 BAIAP2 FBXO31 KLHL20 UBE2W UBOX5 ABI2 UBE2U RNF182 UBA3 ABI1 UBE2O TPP2 UBA1 BLMH UBE2K TGFB1 UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 LMNB1 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP IL1RL2 PJA1 IL36A TAPBP IL36B TRAF7 IL36G UBE2R2 IL36RN SEC22B IL1F10 THOP1 TRIM50 SEC23A MGRN1 ASB13 ASB14 ASB11 CLEC10A RNF6 CLEC4A ASB12 WIPF1 CLEC4E RNF7 WIPF2 CLEC6A ASB17 WIPF3 DHX58 RNF4 RNF125 TAX1BP1 ASB18 RNF216 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 TNFRSF6B HECTD1 EDA HECTD2 TNFRSF13B HECTD3 TNFRSF11B ASB10 EDA2R TNFSF13B FCGR1A TNFRSF17 SEC24B TNFRSF8 TRIM41 ARHGAP45 TNFSF11 SEC24A TNFRSF4 ERAP2 EDARADD RNF25 TNFSF18 FBXL19 IQGAP1 TNFSF14 PLD1 ERAP1 TNFSF15 FBXL15 IQGAP2 FBXL16 CD70 TNFRSF9 FBXL13 EDAR FBXL14 FBXL12 TNFSF6 TRIM39 TNFSF4 LTA ASB8 JUP CD27 ASB9 LNX1 TNFSF9 TNFRSF25 ASB6 ASB7 TNFSF8 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 ARHGAP9 SEC24C ASB1 WASL PTPRZ1 PAG1 WAS STOM PAK3 MYO9B COLEC12 MAP2K1 COLEC11 HSP90B1 ITGAV NCAM1 FTH1 MASP1 FTL ITGB5 XRCC6 XRCC5 PDCD1LG2 B3GNT3 SPOP ITGAX PIAS1 SUZ12 GSK3B GPI ABCE1 HK3 KLRK1 PGAM1 KIR3DS1 PRKDC DHX36 FCER1A LAT2 BCL10 NCR2 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E LPO NKIRAS2 MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 BCL2 TLR10 TLR5 ALPK1 LRRC14 NLRX1 NFE2L2 BCL2L1 PELI3 BTLA PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 JUN IFNA2 IFNA8 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 OAS2 IFNA10 IFNA21 IFNB1 PTPN22 EIF2AK2 ISG15 CD209 NOS1 APEH FGR STIM1 ORAI2 PECAM1 ORAI1 ITPR1 ITPR2 ITPR3 APOB NOS2 NOS3 MME P2RX7 P2RX1 IST1 KPNB1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 RPN2 TUSC3 PRKCSH RPN1 MAGT1 LTA4H ATF6 GOLGA7 OST4 LGMN DDOST LPCAT1 TMEM258 DAD1 OSTC CANX STT3A STT3B PTGS2 ALOX5 KEAP1 TRIM25 RNF123 GATA3 TNFRSF12A TNFSF12 SIAH2 TNFRSF13C TNFRSF11A CD40LG CYLD LTBR LTB IFIH1 TRIM4 IKBKG TOMM70 RIPK2 OSBPL1A PIK3CD PRKN RNF135 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 SMAD3 CXADR SMURF2 SMAD7 NFKBIA MAVS TAB1 RIGI PTEN TNFAIP3 CD74 SLC44A2 GLIPR1 JAML CD99 TRAF2 TRAF3 TRAF6 BIRC2 BIRC3 USP14 BECN1 NOD1 NOD2 USP18 ORMDL3 PTGES2 TNIP2 INPPL1 EIF4A3 ALOX15 PLD4 PLD3 DHX9 ALDH3B1 PCBP2 DEGS1 HNRNPF HNRNPA2B1 ILF3 MYO5A RAB27A THOC5 CEACAM1 ZEB1 IRF4 PPIE CCR5 FPR2 YBX1 SNRPA1 ANXA1 PTAFR MMP3 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA IRAK3 EBI3 MEF2C IFNLR1 B4GALT1 IL20 IL25 IL26 IL24 IL27 IL11 IL19 IL16 IL17RE OSMR IL17RB TXNIP IL31 IL17C IL11RA IL7 IL7R IFNL2 IFNL1 IFNL3 SFN COL1A2 EZH2 KCNAB2 CASP10 FAAP100 FAAP24 FAAP20 FANCM CTLA4 FANCL FANCA FANCB FANCE FANCG FANCF RICTOR STAT1 RORC RORA PDE12 OASL OAS1 OAS3 RNASEL BLK KMT2C FOXO1 SOCS3 NDUFC2 FBXO32 NFKB1 PIN1 FASLG ITGAL TRIM63 ITGA4 TNFRSF18 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 IL2RA NCR3 CD200R1 HCST MUC12 LILRA6 MUC15 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 PTPN4 NCR3LG1 LAIR2 MICA MUCL1 MUC3A MICB MUC5AC NPDC1 MUC3B GLYCAM1 LILRB1 KIR3DL1 LGALS3 KIR3DL2 CFP LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 MUC1 CD8A MUC2 KLRF1 CD300C CLEC4G KLRB1 MUC7 KIR2DL1 MUC4 KIR2DL2 MUC6 KIR2DL3 MUC16 KIR2DL4 CD300LD MUC17 KLRC1 CD300LF MUC19 CD300LG CD160 CRTAM MUC5B MUC20 ULBP1 MUC21 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 WWTR1 YES1 EEF2 SMARCA4 MLEC CTSV CTSL CTSK GBP7 TRIM8 TRIM6 YAP1 TRIM5 TRIM2 TRIM3 CSH1 RELA XAF1 CIITA TRIM68 TRIM62 TRIM46 TRIM48 ARPC1B TRIM45 ARPC1A NPM1 TRIM35 TRIM38 TRIM31 TRIM34 ITCH KLC1 IFITM3 KLC4 IFITM2 KLC3 IFIT5 KLC2 ARPC4 IFI35 ARPC5 IFI30 ARPC2 IFIT3 ARPC3 IFIT2 TRIM29 NF2 ACTR3 TRIM26 ACTR2 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR RAB9B KIF5B IRF8 IRAK1 KIF5A IRF6 NCKIPSD IRF9 SAMHD1 HLA-DOA HLA-DOB LAG3 IL2 CTSO IL3 CTSF IL6 MGST1 CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG CSF1 C4A EED CAT RETN SOD2 FUCA2 KRAS MMP1 MMP2 DNAJC3 JUNB RNF111 PRKCB CST3 PRKCQ CRKL MAPKAP1 NEDD4L CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 NFATC2 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI CDK13 C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A ASH2L C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 CD46 C1QB TEAD2 C1QA C1S C1R TEAD3 TEAD4 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC ICOSLG SNAP25 RAB3A DNAJC5 IL1RN WWP1 IL18RAP IL1R2 IL4 TOLLIP PTPN20 PTPN23 IL18BP IL13 IL1RAPL1 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 CSF2 PTPN7 PTPN5 IL18R1 PTPN2 CNPY3 TLR8 CTSB FKBP5 KPNA7 KPNA4 KPNA5 GBP1 CSF1R KPNA3 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 FANCC PYGL MMP25 TIMP2 OLR1 SERPINB3 BCL6 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 GSTP1 AGA AOC1 AGL ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B WDR5 RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RNF34 RAB5B NLRC4 RAB5C BRI3 HVCN1 GPR84 RAB6A RBBP4 TXNDC5 TRAPPC1 RBBP5 RAB4B PTPRB PTPRC NIT2 RBBP7 ITGAM ITGB2 FCAR ALAD FCGR3B PGM2 ACP3 SNAP29 PML PGM1 RNASET2 TNFRSF1B PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 SOX2 CPPED1 RAB10 NFASC TSPAN14 FCGR2A RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 TWIST1 TXN CHIT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PRG3 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 LIFR CD47 CD44 KCTD6 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 LAIR1 SMURF1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CASP1 CD93 CASP2 CD300A IRAG2 OPRM1 ATAD3B OSCAR TYROBP DOK3 COPB1 IFNG ADGRG3 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 POMC CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 CSK JAK2 NAPRT ADGRE3 HGSNAT FGB DYNLT1 ATP6AP2 FGA PLAUR MMP8 MMP9 FGG CHI3L1 PDXK CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN PROS1 F2 CLTC CLTA CXCL8 AP2A1 CXCL2 AP2A2 AP2M1 CCL11 CCL3L3 CCL5 NPC2 CCL4 CCL3 CCL2 SAR1B CCL19 CCR1 AP2S1 CCL22 CCL20 CXCL10 AP2B1 P4HB POU2F1 LBP VASP STAT5A IL10RA ITK TRAC CD3G FLNA CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 FCGR3A MYH2 MYO10 MYO1C AMPD3 APRT PNP PPP3CA PPP3CB PPP3R1 NFATC1 DNM2 EGR1 JUND FOSB GBP5 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 SLA SLA2 SOCS2 SOCS6 SH2B3 IKBKE IRF7 TANK ACTR1A NEK2 CEP290 NFATC3 TUBB DCTN2 DCTN3 MEFV PSTPIP1 SUGT1 CALM3 CALM2 ATP8A1 IL34 GAB3 ATP11B ATP11A CARD11 MALT1 ATP8B4 RELB CLEC7A CARD9 MAP3K14 GBP6 ANO6 CENPX KIF23 KIF20A DGAT1 FABP5 PRL SNCA DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 SIKE1 IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R TNF CEBPD STAT6 POLR1C POLR1D AGPAT2 GM2A ARSA ASAH1 PSAP TKFC MBL2 GLA IL17RC IL17RA IL17F IL17A CRK UBE2L3 FADD CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 IL1A IL1B PELI1 TLR4 GSN FNTA TICAM2 TICAM1 PKP1 LY96 SDCBP MAOA HMGB1 CASP8 CASP5 CASP4 DSP IRF1 IRF2 DSG1 NCSTN ADAM10 PSEN1 FBXL18 FBXL7 DNM1 FCER2 DNM3 MAPK12 MAPK13 SDC1 HPSE GH1 LYN INPP5D PIK3CG PIK3R6 PIK3R5 BTK ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 JAK1 CISH IL12RB2 HSPA9 IL10 SERPINB2 SOCS5 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 AAMP PPIA AHCYL1 KPNA2 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ADAM17 CYFIP2 HMOX2 TEC STK10 FLT3 IRS1 IRS2 EIF4E3 IFIT1 PIK3CB TCIRG1 PPM1B EIF4E2 FLNB FGF2 CAPZB MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS WASF3 ATP6V1G1 ATP6V0B ATP6V0E1 CD180 LY86 ATP6V1G2 PTPN13 EEA1 PDPK1 TASL RBSN FLT3LG IRF5 GAB2 PIK3CA PIK3R3 ATP6V1B2 TLR9 PIK3C3 TRIB3 ATP6V0D1 FAF2 SOS1 SH3RF1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS RHOU ATP6V0A2 THEM4 ATP6V1H MAPK1 ATP6V0A4 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PTPN1 PTPN11 PLD2 UNC93B1 TLR3 CAMK2B CAMK2D SRC CAMK2A CKAP4 ZAP70 LRRC7 CALM1 DOCK2 CAMK2G DOCK1 ANAPC7 MOSPD2 UBE2C PTK2B UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 ARMC8 FBXW11 OPTN SEM1 APP F13A1 LAMP2 HGF ARG1 SERPING1 PGLYRP4 PGLYRP3 STXBP2 DEFB105B PGLYRP2 KIF5C LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B KIFAP3 S100A7A HSPA5 HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 KIF3B SERPINA3 DEFB117 ORM1 DEFB116 SLC11A1 KIF3C SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 KIF4B DEFB112 ORM2 RNASE3 KIF4A DEFB110 TLR1 DEFB130A BPI KIF11 PRTN3 QSOX1 TIMP1 DEFB130B S100A9 CAP1 DEFB4B S100A8 KIF15 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 KIF22 DEFB123 STX4 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A S1PR1 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 KIF26A ACLY ATG5 ATG12 SLC27A2 TCF7L2 CDKN1A TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ACAA1 EIF2S2 EIF2S1 EIF2S3 ATF3 TREM2 TNRC6C MOV10 MYCN STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 HMOX1 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 NUP214 IDH1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 HSPA8 ICAM1 TNFSF13 VAMP2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 APAF1 CASP3 CFD C3 GZMM CFB FURIN VAPA IL1RL1 IL33 CCT2 ROCK1 CUL3 KIF3A VCAM1 RBBP6 VIM AP1G1 ZBP1 AP1S2 TREX1 AP1S1 DDX41 ITGB7 AP1S3 DTX4 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 NLRP4 TRIM32 HLA-A TRIM21 CD8B TRIM56 ELMO1 CD28 HEXB TNFRSF1A GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 NEDD4 MKRN1 FRK CBL PLCG1 CDKN1B FZR1 FNTB SKP2 CDK4 H2AX CSF3R H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CHRNB4 MYLIP NEU1 FBXL21P CTSA REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 F9 PROC F10 PROS1 FURIN PROZ F2 BGLAP GAS6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R5D PPP2R1B MLXIPL PPP2R1A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases SERPINB1 IL18 CASP5 IL1B CASP4 CALM3 CALM2 GSDMD CALM1 CASP3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 OAZ1 OAZ2 ADRM1 OAZ3 AZIN1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants FLT3 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR7 SC5D DHCR24 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA NGFR LINGO1 MAG OMG RTN4 MCF2 RHOA NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism CD38 BST1 NMNAT3 NMNAT2 NMNAT1 NUDT12 NADK NNMT NAPRT NADSYN1 NMRK2 NMRK1 NAXE NADK2 NAXD NAMPT RNLS SLC22A13 NT5E QPRT SLC5A8 PARP10 SLC25A51 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle ARL6IP5 GAD1 GAD2 CHAT SLC18A3 SLC17A7 NAAA STX1A CASK LIN7A LIN7C LIN7B APBA1 SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT GLS2 SLC6A1 CPLX1 RIMS1 UNC13B ALDH5A1 GLS DNAJC5 SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC1A1 SLC1A2 SLC1A3 SYN3 SLC1A6 SYN2 SLC1A7 HSPA8 VAMP2 SLC38A2 MAOA SYN1 SLC6A11 SLC6A12 SLC5A7 TSPOAP1 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle CLTC IQGAP1 PTK2B VANGL1 WWP2 ARHGEF7 PIK3R2 PIK3R1 RHOU ARHGEF6 STAM ARHGAP31 ARHGAP30 SPTAN1 STAM2 GIT1 TXNL1 HGS MYO6 CDC42 DEPDC1B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 SRC ITSN2 PAK1 PAK3 SRGAP2 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair PCNA ERCC6 PCLAF REV1 ISG15 USP43 SPRTN MAD2L2 REV3L ISY1 FIRRM SIRT6 PNKP POLK POLE OGG1 PIAS3 UBE2T RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 UBE2L6 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 HERC2 ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 CDK2 MAPK8 MDC1 FEN1 USP1 DTL UBE2I SUMO1 RBX1 TRIM25 NFRKB CCNH PIAS4 POLR2A POLR2B POLR2C BRCC3 POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J NPLOC4 POLR2K POLR2L MSH3 GTF2H1 GTF2H2 BAP1 GTF2H3 WDR48 GTF2H4 BABAM1 GTF2H5 BABAM2 CDK7 ERCC3 POLI ERCC2 UIMC1 MNAT1 UFD1 ACTB UBB ACTL6A UBC DDB2 RPS27A FAAP100 FAAP24 FAAP20 UBA7 FANCM ERCC8 FANCL FANCA FANCB FANCE FANCG FANCF KPNA2 TP53 DCLRE1C RIF1 MCRS1 POLL NHEJ1 UBE2B POLM TDP2 TDP1 PARG APEX1 ADPRS POLQ KDM4B YY1 RUVBL1 USP7 ABL1 PMS2 MPG MUS81 GPS1 SLX4 EME1 INO80C EME2 INO80B GEN1 INO80E SLX1B VCP INO80D COPS4 SPIDR FANCI COPS2 FANCC CLSPN RNF4 FIGNL1 POLB RNF168 NSD2 CENPX ACTR5 RAD23A ACTR8 RAD23B MSH2 RTEL1 ABRAXAS1 USP10 TP53BP1 UVSSA H2AX TFPT LIG1 H2AB1 MSH6 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 DCLRE1B H2BC21 DCLRE1A POLN FAN1 RNF8 H2AC8 H2AC6 CHEK2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG MBD4 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 MGMT TERF2 H2BC8 H2BC5 SMUG1 NEIL3 XRCC6 H2BC3 AQR XRCC4 H3-4 NEIL2 XRCC5 PARP1 H2BC1 POT1 LIG4 TERF2IP PPP4R2 NEIL1 TIPIN H2AC20 TIMELESS ZNF830 PPP4C POLH RAD52 MLH1 KDM4A FANCD2 SUMO3 SUMO2 PIAS1 PRPF19 PAXIP1 SMARCA5 CENPS PRKDC BAZ1B XAB2 BLM MRE11 RAD18 BRCA1 BRCA2 RAD51AP1 ELL WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 APBB1 RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 EYA4 PPP5C RMI1 TCEA1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 PPIE CCNA2 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR KANK1 ETV6 GOLGA4 BIN2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INS ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 PTPN1 INSR TCIRG1 IDE PTPRF ATP6V1E1 CTSD ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs RASA3 RASA4 RASA2 NRAS CUL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 KBTBD7 PSMA4 PSMA1 NF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 SPRED3 SPRED2 PSMB7 SPRED1 RASAL2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RASA1 ADRM1 SYNGAP1 PSMC5 PSMC6 HRAS SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DAB2IP RASAL1 RASAL3 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 SEC61A2 SEC61A1 CHUK TIRAP TAPBP IKBKB SEC22B MYD88 CALR B2M HLA-A TLR1 VAMP8 S100A9 PSMB10 PSMD8 PSMD6 TLR6 S100A8 PSMD7 TLR2 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMA5 STX4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK CD14 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 FGA PSMB4 TAP2 FGG PSMB5 IKBKG TAP1 TLR4 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A LY96 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 HMGB1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB ACADL HADHA ECHS1 HADH SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 SENP5 NUP107 SENP2 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 SENP1 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG RWDD3 UBA2 DNMT1 SAE1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency OTC BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A2 CYP1A1 ALOX15 LTA4H MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 TAB1 MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PTK6 CDKN1A CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 NUMA1 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events PRKCA PLCB4 GNAQ ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 NBEA PLCB2 CALM1 CAMK2G PRKCD INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling IFNA2 TRIM6 TRIM5 IFNA8 TRIM2 TRIM3 ARIH1 XAF1 IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 NPM1 TRIM45 TRIM35 TRIM38 OAS2 TRIM31 TRIM34 IFITM3 IFITM2 IFNA10 HSPA5 IFIT5 IFI35 IFNA21 IFI30 RAF1 IFIT3 IFNB1 IFIT2 EIF2AK2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 ISG20 YBX1 PRKRA IRF8 IRF6 TARBP2 IRF9 IFNAR1 SAMHD1 PTAFR FLNA HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 KPNB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 FNTA DNAJC3 STAT2 UBE2L6 HERC5 UBE2N ADAR IRF1 IRF2 HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E HSPA1L HSPA2 ATF6 HSPA1B SOCS1 EIF2S2 IFNGR1 EIF2S1 IFNGR2 EIF2S3 EGR1 IKBKB EIF4E UBE2I GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 IRF7 PSMB8 NUP214 PRKCD SFN UBA52 IFIH1 JAK1 ACTB IKBKG UBB UBC TYK2 PTPN2 RPS27A FAAP100 FAAP24 HSPA8 ICAM1 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 KPNA7 FKBP5 KPNA4 KPNA5 GBP1 KPNA3 FURIN FCGR1BP SPHK1 MAP2K6 STAT1 MT2A VCAM1 FANCC B2M SMAD7 IRF3 MAVS HLA-A TRIM21 GBP6 RIGI NUP205 POM121 NUP107 NUP188 FCGR1A AAAS NUP160 POM121C NUP42 NUP85 TPR CENPX NUP62 NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B PML EIF4E2 FLNB MX2 MX1 EIF4G3 EIF4G2 NCK1 SOCS3 EIF4A2 EIF4A1 IRF5 EIF4A3 NCAM1 PPP2R5A STAT3 BST2 MAPK1 DHX9 PIN1 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CD44 PPP2CA PPP2CB IFITM1 CAMK2B PIAS1 CAMK2D SNCA CAMK2A CASP1 EIF2AK3 CAMK2G CENPS IFNG ABCE1 UBE2E1 CDK1 JAK2 ILF3 PTPN6 IRF4 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 TRIM8 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CLPS CEL LIPF PNLIP PNLIPRP3 PNLIPRP1 PNLIPRP2 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors AP2A1 AP2A2 NPM1 AP2M1 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 BTRC NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 KPNB1 CD4 RCC1 RAC1 RANBP1 RANGAP1 ATP6V1H PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 DOCK2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 ARF1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNT1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDK9 RPS27A CUL5 ADRM1 PPIA HCK PSMC5 PSMC6 SEM1 LCK PSMC3 FYN PSMC4 PSMC1 PSMC2 SKP1 PAK2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis XIAP CYCS STAT3 DYNLL1 UACA BAK1 GZMB CDKN2A DYNLL2 MAPK1 BID PPP1R13B MAPK8 BCL2L11 MAPK3 BAD PMAIP1 YWHAB YWHAE AKT1 YWHAQ YWHAG YWHAH YWHAZ SFN GSDMD NMT1 GSDME PPP3CC BAX C1QBP E2F1 TP63 TFDP1 TFDP2 CARD8 BBC3 BCL2 BCL2L1 AKT2 BMF AVEN TP73 APIP TP53 CASP8 CASP9 PPP3R1 TP53BP2 CASP7 APAF1 DIABLO CASP3 AKT3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species NCF1 PRDX2 CYCS NCF2 PRDX1 NCF4 NUDT2 CAT PRDX3 NOX5 ERO1A TXN2 GPX3 GPX6 GPX5 GPX8 SOD2 GPX7 ATP7A CYBB TXNRD2 CYBA PRDX6 ATOX1 SOD3 CCS TXNRD1 SOD1 P4HB GPX1 GSTP1 AQP8 TXN NOX4 GPX2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) MSH6 MLH1 PMS2 MSH2 MSH3 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i ALG2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CAMK2D CALM1 CAMK2G CAMK2A REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements ATF7IP ZNF547 ZNF224 MBD3 GATAD2B GATAD2A ZNF778 RBM7 ZNF454 CHD4 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 MTA1 MTA3 RBBP7 SMARCE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MORC2 H2AC6 H2AC7 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ZNF141 HDAC1 ZNF382 H2AC20 ZNF418 ZNF354A ZNF136 ZNF649 EHMT2 EHMT1 CHD3 SUMO2 UBE2I DPF1 HDAC2 DPF2 DPF3 ZNF28 CBX5 ZNF273 SETDB1 SS18L1 ARID1A ARID1B ZNF816 ZNF610 SS18 SMARCB1 ZNF264 PPHLN1 TRIM28 ZNF30 ZNF257 SMARCC1 SMARCC2 ZNF33A MPHOSPH8 ACTB SPOCD1 ZNF331 ZNF93 ZCCHC8 ACTL6A MTREX TASOR ZNF708 ZNF324 ZNF534 PIWIL4 DNMT3L BCL7A ZNF320 BCL7C SMARCA2 BCL7B SMARCA4 ZNF765 DNMT3A ZNF317 C19orf84 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 MIB2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRR5 DPY30 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 BRD4 PDCD1 RAC1 COPS5 VAV1 MAPKAP1 IRF1 RPN2 TCF7L2 TUSC3 TCF7L1 RPN1 LEF1 MAGT1 TCF7 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MLST8 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 MTOR TEAD3 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 AKT1 PSMD1 HIF1A ICOSLG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 JAK1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PAK2 RICTOR CUL3 VCP STAT1 MAP3K14 CD28 WDR5 RBBP4 RBBP5 RBBP7 CDK4 PPP2R1B H2AX PPP2R1A PIK3CB H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 AKT2 H3-3B H3C8 H2AC8 H2AC6 PAK3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PDPK1 H2BC15 H2BC11 PIK3R3 KMT2A PIK3CA TRIB3 H3C15 PPP2R5E H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D STAT3 PPP2R5C PIK3R2 H2BC1 PIK3R1 NFKB1 PDCD1LG2 B3GNT3 H2AC20 SPOP THEM4 PTPN11 CDC42 PPP2CA PPP2CB SUZ12 GSK3B CD86 CD80 NFKB2 CSK CD274 MAP3K8 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 WWTR1 YES1 SEM1 LCK FYN SKP1 FOS CUL1 AKT3 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy MAP1LC3A CETN1 FUNDC1 PARK7 ATG5 TOMM20 ATG9A ATG12 ULK1 DYNLL1 TOMM7 ARL13B MFN1 TOMM5 DYNLL2 MFN2 TOMM6 TOMM22 HSF1 IFT88 VCP DYNC1I2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 SQSTM1 PLIN3 DYNC1I1 TBK1 PRKAB2 DYNC1H1 PRKAB1 UBE2D2 UBE2D3 EPAS1 PINK1 USP30 VDAC3 VDAC2 VDAC1 UBE2L3 MAP1LC3B CFTR HSP90AA1 UBA52 HDAC6 PLIN2 TOMM70 UBB UBC DYNC1LI1 PEX5 RPS27A NBR1 DYNC1LI2 UBE2V1 OPTN PRKN HSPA8 CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 UBE2N PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly APOC4 A2M APOC3 APOC2 APOC1 P4HB APOA2 ZDHHC8 APOA1 APOA4 APOB PRKACG PRKACA PRKACB APOE ABCA1 SAR1B MTTP CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling CD86 CD80 PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 RICTOR MAP3K8 PIK3CB MLST8 PIK3CD AKT2 MAP3K14 MTOR LCK CD28 FYN PRR5 PDPK1 AKT1 PIK3R3 PIK3CA MAPKAP1 AKT3 TRIB3 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B1 SLCO1B3 ABCC1 ABCG2 ALB GSTA1 UGT1A4 HMOX1 BLVRB HMOX2 ABCC2 BLVRA UGT1A1 FABP1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B2 SRD5A3 CGA HSD3B1 CYP17A1 HSD11B1 HSD11B2 STARD3NL CYP19A1 POMC CYP11A1 STS SRD5A2 SRD5A1 HSD17B1 CYP11B2 SERPINA6 HSD17B2 CYP11B1 TSPO LHB HSD17B3 HSD17B12 CYP21A2 FDXR STARD3 STARD4 STAR STARD6 AKR1B15 HSD17B14 FDX1 HSD17B11 FDX2 AKR1B1 TSPOAP1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation RPS6KA1 ATF1 MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 RPA1 ERCC8 DDB1 RPA2 XPA POLE4 CUL4A RPA3 PPIE ERCC4 ERCC1 POLE2 POLE3 ERCC5 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGAP32 ROCK1 ROCK2 ARHGAP44 PREX2 ARHGAP40 ARHGDIA HMOX2 STARD8 ARHGAP8 ARHGAP45 AAAS ARHGEF25 CIT IQGAP1 PKN3 PLD1 IQGAP3 STX5 ARHGAP22 ARHGAP20 SRGAP1 STARD13 JUP VMA22 ARHGAP29 ARHGAP24 PKN2 PKN1 ARHGAP31 FAM13A STK10 ARHGAP30 SLK C1QBP ARHGAP9 ARHGAP11B TEX2 ARHGAP4 DDRGK1 TAGAP PLEKHG3 PLEKHG4 BCAP31 ARAP1 GMIP ARHGAP11A TJP2 ARHGAP10 DAAM1 TRIO RASGRF2 PLEKHG6 ARHGEF10L AKAP13 PREX1 STOM MCF2L ARHGEF40 FARP1 VAV3 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 DEF6 VAPB KTN1 ARHGEF15 PLEKHG5 DLC1 TMEM87A DIAPH1 ARHGEF17 FLOT1 ARHGEF19 SCFD1 DIAPH3 FLOT2 ARHGEF18 VAV1 VAV2 ANLN TIAM1 FAF2 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF KALRN RHOA EMC3 CAVIN1 MYO9A ABR RTKN ECT2 ARHGEF28 ARHGAP19 ARHGAP18 MCF2 NET1 RHPN1 RHPN2 ACBD5 MACO1 ARHGAP28 ARHGAP23 FMNL3 ABCD3 SOWAHC DOCK2 TFRC SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP42 OPHN1 STBD1 ARHGDIB LBR TMPO ARAP2 ARAP3 BCR DEPDC1B VAMP3 ARHGAP21 LMAN1 PGRMC2 RACGAP1 YKT6 CAV1 MCAM ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SLC39A2 SLC39A1 SLC39A3 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis IRF1 XIAP IRF2 CYCS CHMP3 CHMP6 TNFRSF10B CHMP7 TNFRSF10A BAK1 GZMB ITCH FAS FASLG RIPK1 OGT CASP1 STUB1 UBE2L3 TRAF2 TNFSF10 HSP90AA1 CDC37 UBA52 BIRC2 FADD ELANE BIRC3 GSDMD GSDME BAX TP63 RIPK3 IL18 IL1A IL1B PELI1 UBB UBC RPS27A CHMP4C CHMP4B CHMP4A PRKN SDCBP MLKL CHMP2B CHMP2A TRADD HMGB1 TP53 CASP8 CASP5 CASP4 FLOT1 FLOT2 CASP3 PDCD6IP ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 SEC22B SERPINA1 SEC23A COPE ARF4 F5 TMED3 F8 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 NSF CTSC CAPZA3 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A TMED2 SPTB DYNC1I1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ANK1 AREG DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 TGFA YKT6 ARFGAP1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RXRA CREBBP CHD9 PPARGC1A NCOA2 NCOR1 NCOA6 TBL1XR1 EP300 SMARCD3 MED1 TGS1 HDAC3 RORC RORA NR1D1 NRIP1 CARM1 TBL1X NCOA1 CPT1A SREBF1 HELZ2 PPARA REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 UBC TICAM2 TICAM1 RPS27A TBK1 TRAF3 OPTN LY96 UBA52 CD14 IKBKE TANK UBB TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation RELA MAP3K7 RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CARD11 IGKV2D-28 MALT1 IGKV4-1 IGHV7-81 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 TAB1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV TRAF6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 PRKCQ UBE2N NFKB1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 V1-11 V1-16 V1-13 CHUK V2-8 IKBKB V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 LYN PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 RASGRP4 CUL1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors LDLRAP1 CUBN AMN APOA2 ACO1 APOA1 ABCD4 APOA4 SLC2A1 PRKG2 PRSS3 LPL LMBRD1 LDLR GPIHBP1 APOC3 LRP8 FLAD1 RFK SLC52A2 APOB SLC52A3 ACP5 SLC52A1 NOS3 ENPP1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR PDZD11 GCHFR GCH1 SPR PTS NNMT PNPO AOX1 NAMPT SLC5A6 ACACA STARD7 FASN COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A SDC4 SDC2 SDC3 SLC46A1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 AKT1 IDH1 COQ2 GSTO1 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC PCCA HLCS MCCC1 PCCB ACACB NUDT12 NADK CYB5R3 THTPA TCN1 NMRK2 NMRK1 RBP4 NAXE RBP1 LRAT NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MOCOS MMAB SLC22A13 QPRT SHMT2 MTRR SLC25A51 SLC25A19 CD38 GPHN HSP90AA1 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 NMNAT1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 TCN2 CD320 AKR1C1 TTR CBLIF AKR1C4 MMACHC MMADHC PLB1 BST1 VNN1 HSPG2 APOE GSTO2 AGRN APOC2 ABCC1 MTR SLC2A3 CALM1 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 BCO1 VKORC1 AKR1B10 NAPRT CLPS RBP2 LRP10 LRP12 PNLIP PDXK NADK2 RDH11 AKR1C3 SLC5A8 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation YARS1 EEF1E1 KARS1 EPRS1 NARS1 IARS1 PPA1 TARS1 AARS1 CARS1 HARS1 FARSA FARSB RARS1 LARS1 AIMP1 AIMP2 WARS1 QARS1 MARS1 GARS1 DARS1 SARS1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP9 DUSP4 TYK2 DUSP6 DUSP7 DUSP10 IL6R CDK1 IL6 PEA15 MAPK1 DUSP5 DUSP2 DUSP1 JAK2 DUSP16 JAK1 MAP2K1 MAP2K2 MAPK3 PTPN11 DUSP8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 SLC19A3 SLC19A2 THTPA TPK1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA1 GRIA2 GRIA3 GRIA4 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C CDK2 MDC1 CLSPN SUMO2 UBE2I RNF4 RNF168 NSD2 PIAS4 BRCC3 UBA52 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN UBB TOPBP1 SIRT6 ATRIP BARD1 RFC5 UBC RMI2 H2BC26 RFC3 RFC4 RPS27A H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB DCP1A ZFP36L1 EXOSC7 EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway CHST8 CHST10 FUT3 FUT8 MAN2A2 CGA MAN2A1 LHB MGAT2 FUCA1 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion F9 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development ROBO2 WFDC2 MECOM GFRA1 OSR1 GATA3 HOXA6 BMP4 PAX8 PLAC8 FOXC2 ITGA8 CTNNB1 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 GREM1 SALL1 SIX2 EYA1 FGF2 HOXB4 IRX1 ID4 LFNG IRX2 JAG1 SLIT2 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 POU3F3 WNT4 WNT11 ITGB1 EMX2 PCDH19 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 CLTC CLTB FZD5 WNT5A AP2S1 ROR1 CLTA ROR2 AP2A1 AP2A2 AP2B1 AP2M1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils PXDN LOXL1 PCOLCE LOXL2 TLL2 TLL1 LOX LOXL3 LOXL4 BMP1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAH SFN YWHAZ YWHAE PDPK1 AKT1 AKT2 YWHAQ CAV1 YWHAG YWHAB AKT3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility ITGA3 CRK LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 RAP1B RAP1A ITGA2 MET DOCK7 RAPGEF1 TNS4 TNS3 SRC RAC1 GAB1 HGF PTK2 CRKL ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 HBB APOA1 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 BACH1 CLOCK NPAS2 TLR4 HELZ2 RAI1 CREBBP CHD9 MAFK NCOR1 SLC46A1 MEF2C TBL1XR1 NFE2L2 EP300 LY96 CLEC1B MED1 TGS1 MEF2D PGRMC2 APOB HBA2 RORA HMOX1 SIRT1 XPO1 PPARA CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway CDC42 LCK CD28 RAC1 FYN CD86 CD80 PAK2 VAV1 PAK1 PAK3 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 ARPC1A LDLRAP1 AP2M1 BIN1 STAM2 ARPC4 STON1 GPS1 ARPC5 STON2 ARPC2 ARPC3 SNX18 COPS4 ACTR3 ACTR2 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 CTTN SGIP1 AP2S1 AGTR1 DNAJC6 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 HIP1R AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 FNBP1L SNX9 APOB SNAP91 M6PR SYT2 GAK ARRB1 FNBP1 ARRB2 SCARB2 AMPH PACSIN2 PACSIN3 PACSIN1 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 RAB5B RAB5C TGOLN2 CHRM2 ARF6 HGS RAB5A WASL CD4 GAPVD1 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 TRIP10 DNM1 SLC18A3 DNM2 DAB2 EPS15L1 EPN1 PIK3C2A SYT9 GRK3 PICALM VAMP8 DNM3 IL7R TFRC PIP5K1C CFTR SYT1 IGF2R UBA52 STAM HIP1 OCRL UBB SYNJ2 SYNJ1 UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 HSPA8 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG ARFGAP1 BTC EPGN HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON SPOP ITCH CUL3 KIF7 IHH SMO GPR161 KIF3A PTCH1 GLI3 GLI2 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 ARRB1 PSMD2 RBX1 ARRB2 PSMD3 PSMD1 CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 NUMB PSMD13 PSMA7 PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 PSMC2 ULK3 GRK2 DZIP1 SPOPL REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway FYN SH3KBP1 VLDLR RELN DAB1 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LDLR APOE LIPC LDLRAP1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation RXRA MED19 MED18 SREBF2 MED11 RELA WNT1 NFKB1 MED9 MED29 KLF5 MED28 MED22 TGFB1 MED21 HDAC3 CDK19 CEBPB TBL1X MED13L ANGPTL4 PCK1 NCOA1 LPL EGR2 FABP4 CDK8 NCOR2 NCOR1 TBL1XR1 PLIN1 THRAP3 LEP FAM120B CD36 PPARGC1A NCOA2 NCOA6 NCOA3 CCNC SMARCD3 CCND3 CARM1 ADIPOQ CDK4 MED16 HELZ2 MED15 KLF4 MED17 CREBBP CHD9 MED12 MED14 MED13 TNF MED10 EP300 EBF1 WNT10B NR2F2 ADIRF SLC2A4 MED1 MED30 ZNF638 TGS1 CEBPD MED31 ZNF467 MED8 MED4 MED27 MED6 MED26 MED7 MED23 MED25 CEBPA MED24 MED20 PPARG PPARA DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CREBBP BMAL1 KMT2A CLOCK TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 YAP1 SERPINB13 ABL1 ITCH GPAM ARID2 ESR1 AUTS2 IL2 IL3 TCF3 LDB1 SIN3B DPY30 WDR5 CR1 ELF1 ELF2 SMARCD1 SMARCD2 FOXP3 SMARCD3 CCND3 CCND2 RBBP5 CDK6 BLK SMARCE1 KMT2D H2AX SPI1 PML H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 MYB EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ ZFPM1 H2BC15 PRKCQ TAL1 H2BC11 KMT2A CBFB ITGA2B SOCS4 GATA2 H3C15 OCLN H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 GP1BA SETD1B SETD1A NFATC2 CCND1 SIN3A TJP1 LMO1 YAF2 LMO2 PTPN11 LIFR KCTD6 TNFRSF18 ASH2L TNRC6C MOV10 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 RSPO3 SRC TNRC6A TNRC6B CLDN5 NR4A3 RNF2 PSMD8 PSMD6 CBX8 PSMD7 PHC2 TCF12 MYL9 PHC1 PAX5 PSMD2 CBX4 PSMD3 CBX2 PSMD1 PHC3 ARID1A IL2RA ARID1B GATA1 AXIN1 IFNG CCNH PSMA5 PSMA6 PSMA3 GATA3 PSMA4 THBS1 PSMA1 SMARCB1 PSMA2 LGALS3 UBA52 PSMD12 PSMD11 PCGF5 PSMD14 PSMD13 PSMA7 HIPK2 SMARCC1 SMARCC2 PSMB6 RYBP CDK7 PSMB7 PSMB4 MNAT1 PSMB5 PF4 UBB PSMB2 CSF2 ACTL6A PSMB3 CREBBP UBC PSMB1 RPS27A KAT2B CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 SMARCA2 PSMC4 SMARCA4 ACTL6B PSMC1 CSNK2B PSMC2 TP73 CTSV CTSL CTSK PBRM1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KPNA6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins DEFA5 DEFA3 ART1 DEFA1B PRSS3 PRSS2 CD4 DEFA6 DEFA4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNA6 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor RASGRF2 CAMK2B NRAS CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism MTR MTRR MMAA MMUT MMAB MMACHC MMADHC DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF1 ALYREF DDX39B CPSF3 CPSF2 SRRM1 DHX38 NXF2B SYMPK NXT1 UPF3B MAGOHB EIF4E RNPS1 NUP205 WDR33 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG GALE DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide VCP TCF25 ANKZF1 KLHDC10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism ACADSB ACAD8 MCCC2 ECHS1 ACAT1 MCCC1 BCAT1 SLC25A44 BCAT2 ALDH6A1 HIBADH PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH HSD17B10 DLD GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation OGDH KGD4 GCSH GLDC AMT DLST DLD CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly CEP41 CEP43 IFT172 KIFAP3 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 RPGRIP1L CCT3 PRKACA WDR35 IFT88 SMO TCP1 KIF3A TTC21B WDR19 IFT122 KIF3B MKS1 KIF3C ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CEP97 YWHAE CNGA4 TUBB4B KIF17 BBS5 TUBB4A BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 YWHAG BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B HSP90AA1 ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 HDAC6 RHO RAB11A ATAT1 TTC8 CNGB1 PPP2R1A CPAP DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 PDE6D MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 TNPO1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DDX21 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway UBC TAB3 RPS27A ALPK1 TAB2 MAP3K7 TRAF6 UBA52 UBB TIFA TAB1 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 NGF PLCG1 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events HRAS MAPKAPK3 RALGDS RALB MAPK12 MAPK13 MAPKAPK2 NRAS MAPK14 MAPK11 RALA SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL3 ITGA1 RHOC HSP90AB1 RHOA RHOB ROCK1 ROCK2 PLXNC1 MET SEMA6A PLXNA4 SEMA6D SEMA7A CDK5R1 PLXNB3 TREM2 SEMA3E SEMA4A CDK5 SEMA5A RND1 MYL9 GSK3B TYROBP SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 FARP2 HSP90AA1 ERBB2 CD72 ARHGAP35 PLXND1 CFL1 PTPRC PLXNA1 PLXNB1 TLN1 SEMA4D PAK1 PAK3 LIMK2 RAC1 LIMK1 MYL12B FYN MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 MYH10 PAK2 NRP1 CRMP1 ITGB1 DPYSL4 DPYSL5 DPYSL2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism CYB5B VAPA GAL3ST1 CERK GBA3 GBA2 MFSD2B SMPD3 SMPD2 SPHK1 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLPP3 SUMF1 PLPP2 B3GNT5 PLPP1 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 SGPL1 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG ACER2 HEXB ARSD ACER1 HEXA B3GALNT1 GLB1L3 B3GALT4 M6PR ACER3 GLB1L2 GALC GLA GLB1L GLB1 SPTLC1 ARSB SPTLC2 SPTLC3 ORMDL2 ORMDL3 SPTSSB SPTSSA ORMDL1 VAPB PRKD3 PRKD2 PRKD1 SPNS2 ABCG2 ALDH3B2 ALDH3B1 FA2H DEGS1 DEGS2 SPHK2 SAMD8 SGMS1 ABCC1 SGMS2 OSBP SGPP2 SGPP1 CSNK1G2 KDSR ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CERS3 ST3GAL2 CERS4 ST3GAL3 CERS5 CTSA CERS6 CERS1 CERS2 PPM1L SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 GNAQ GNA15 PLCB3 PLCB1 FFAR1 PLCB2 GNA11 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A3 SLC26A9 SLC26A6 SLC26A11 SLC26A1 SLC26A4 SLC26A7 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly APOC4 APOB APOC1 MTTP P4HB M PHASE%REACTOME%R-HSA-68886.5 M Phase PRKACA YWHAE EML4 CDCA5 NCAPG YWHAG ARPP19 NCAPH ENSA SIRT2 USO1 NCAPD2 TUBB8 RAB2A IST1 VRK1 LEMD2 TUBB8B NUMA1 FIRRM ESPL1 RAB1A RAB1B GOLGA2 FBXO5 BLZF1 KPNB1 SPAST CC2D1B CNEP1R1 PTTG1 MASTL GORASP2 GORASP1 PPP2R2D CHMP4C CHMP4B CHMP4A PRKAR2B PRKCB CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 TUBB PSMB6 CEP131 PSMB7 HAUS4 HAUS3 CSNK1D PSMB4 HAUS6 PSMB5 HAUS5 CSNK1E TUBG2 LEMD3 UBB TUBG1 PSMB2 PSMB3 TUBB6 HAUS2 TUBB3 HAUS1 MZT2B TUBB1 UBC MZT2A PSMB1 NME7 AKAP9 RPS27A CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 ADRM1 CSNK2A1 DCTN3 HAUS8 PSMC5 HAUS7 CSNK2A2 CEP70 PSMC6 CEP72 PSMC3 TUBA4B CEP192 PSMC4 PCNT PSMC1 TUBA4A CSNK2B CEP76 PSMC2 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS KMT5A NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 HSP90AA1 NDC1 RANBP2 SEC13 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 CPAP KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 RCC1 H2BC21 ZW10 MAD1L1 H3-3B CDCA8 H3C8 H2AC8 PMF1 SKA1 H2AC6 SKA2 KIF23 H2AC7 DSN1 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 RCC2 STAG1 H2BC15 NIPBL NDC80 ZWINT STAG2 H2BC11 RAD21 KIF20A KIF18A RPS27 AHCTF1 H3C15 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 H2AC20 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 LPIN1 CENPT LPIN2 DYNC1H1 CENPU LPIN3 NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 TIAM1 RAC1 NTRK2 BDNF CDK5 CDK5R1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 PSEN1 UBB NOTCH2NLA UBC NOTCH2NLC NOTCH2NLB RPS27A MDK JAG2 JAG1 DLL1 NOTCH2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA AREG EGF MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CLIP1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G2D PLA2G2E MBOAT1 PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 ABHD4 PLAAT1 PLAAT3 PLA2G2A PLAAT2 PLAAT5 PLAAT4 PLA2G4A PNPLA8 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 LPCAT3 PLBD1 PLA2G2F REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A11 SLC6A13 SLC6A12 SLC6A1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 LIPC LDLRAP1 UBA52 AP2M1 CUBN AMN APOA1 LSR NPC1 SOAT1 SOAT2 APOE NPC2 CES3 UBB MYLIP NR1H2 APOC4 UBC AP2S1 NR1H3 LDLR RPS27A APOBR AP2B1 APOC1 NCEH1 APOB BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import TOMM20 GFER OTC TOMM7 TOMM5 TOMM6 SAMM50 TOMM22 MTX1 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX19 COX17 ATP5MC1 TIMM50 PITRM1 GRPEL1 GRPEL2 LDHD CYC1 DNAJC19 COA4 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 HSPD1 ACO2 HSCB TIMM17A TIMM17B COA6 SLC25A4 SLC25A6 TIMM23 TIMM22 HSPA9 TIMM21 TOMM70 SLC25A12 PMPCB FXN PMPCA SLC25A13 NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B VPS28 CHMP4A TSG101 VPS37C VPS37D VPS37A VPS37B GABARAP CHMP2B CHMP2A MVB12B EEF1A1 MVB12A UBAP1 UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A RNASE1 CHMP3 ATG12 GFAP ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B HSP90AB1 DYNLL2 HBB TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B LAMP2 ATM MTERF3 WIPI1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates NUDT13 AK1 RRM2 AK2 AK4 NME1 AK5 AK6 AK7 AK8 DCTPP1 AK9 GLRX NME2 NME3 NME4 DCTD TXNRD1 CMPK1 TYMS CTPS2 CTPS1 RRM1 RRM2B DTYMK TXN GUK1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate SRD5A3 MVD DOLK DOLPP1 DHDDS NUS1 DHRSX DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k ALG1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling DUSP6 DUSP7 KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G DUSP8 DUSP9 IQGAP1 MRAS FAM114A2 QKI NF1 KIAA1549 DUSP10 ESRP1 TRIM24 FXR1 FN1 PHB1 AGTRAP MAP3K11 ARAF AP3B1 PEBP1 SHOC2 CSK AGGF1 JAK2 TENT4A DUSP16 MARK3 SPRED3 FGB SPRED2 BRAP SPRED1 FGA VWF KSR1 KRAS PPP1CB FGG PPP1CC BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes ACSS3 CXXC1 AGPAT2 ABL1 KANSL1 KANSL2 KANSL3 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 TADA3 OGT DPY30 WDR5 PSIP1 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA KMT2A H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 SETD1B SETD1A HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 PHF20 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 KAT8 HCFC2 WDR82 PAXIP1 PEX11A AJUBA KAT14 ZZZ3 HCFC1 TADA2A SGF29 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC PHF20L1 NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 BOD1L1 CREBBP MED17 MBIP MED12 TASP1 MED14 DR1 MED13 BOD1 KAT2B KAT2A YEATS2 MED10 MEN1 AKAP8L PAGR1 MED27 KDM6A SIRT1 MED23 MCRS1 MED24 MED20 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED1 CITED2 CITED4 CGA YY1 HSPD1 ERBB2 VEGFA CDKN1A EGFR DEK NPM1 APOE ATAD2 CREBBP YEATS4 NOP2 TFAP2A TFAP2B ESR1 EP300 WWOX MYC TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 KDM5B CGB8 TGFA KIT MYBL2 PITX2 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly APOA1 APOA4 APOB APOE APOC2 APOC3 SAR1B MTTP P4HB APOA2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant F9 F10 F8 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway BAIAP2 ABI2 PIK3R2 PIK3R1 ABI1 NRAS RHOA THEM4 RICTOR ROCK1 ROCK2 PRKACG PRKACA CTNNB1 PRKACB SPHK1 ELMO2 CDC42 MLST8 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 MTOR HSPB1 SHC2 NOS3 PRR5 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA NCF2 KDR CRK NCF4 PTK2B PXN BRK1 HSP90AA1 MAPKAPK2 JUP CTNND1 PLCG1 CTNNA1 SHB CYBB CYBA SH2D2A PIK3CB MAPKAPK3 CDH5 AXL NCK2 NCK1 RASA1 AKT2 MAPK14 PRKCZ MAPK11 PAK1 PAK3 RAC1 HRAS PRKCB WASF3 BCAR1 AHCYL1 FYN VAV3 PDPK1 NCKAP1L WASF1 PAK2 WASF2 PTK2 PIK3CA ITGB3 VAV1 VAV2 CAV1 AKT3 ITGAV TRIB3 MAPKAP1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair PCNA KDM4B ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 CHEK2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 PARP1 H2BC1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MAPK8 MDC1 KDM4A FEN1 SUMO2 UBE2I SUMO1 PAXIP1 SMARCA5 PIAS4 BRCC3 UBA52 PRKDC BAZ1B BAP1 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 APBB1 UBC RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 RPS27A EYA4 PPP5C RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 KPNA2 RAD17 DCLRE1C TP53 CCNA2 RAD1 RIF1 ATM CCNA1 DNA2 POLL NHEJ1 RAD9B RHNO1 POLM TDP2 ATR TDP1 RAD9A POLQ METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors COQ9 DHFR COQ7 COQ6 COQ5 COQ2 COQ4 HSP90AA1 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ACO1 GCHFR GCH1 SPR PTS PRKG2 NOS3 STARD7 AKT1 CALM1 IDH1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells EOMES SOX17 CXCR4 BMP4 PDPN PRDM1 TET2 TFAP2C POU5F1 NANOG NANOS3 CBFA2T2 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism CPOX SLCO1B1 SLCO1B3 ABCG2 UROD GSTA1 UROS ALAS2 BLVRB ABCC2 BLVRA COX15 ALAD FABP1 FECH COX10 PPOX ALAS1 HMBS ABCC1 ALB UGT1A4 HMOX1 HMOX2 UGT1A1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication HDLBP KPNA7 NACA FASN KPNA4 KPNA5 KPNA3 BTF3 RPN2 BAG2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 VCP SPCS2 DNAJA2 PRKG2 SPCS1 OST4 SEC11A RTN3 SEC11C HSPA1B DDOST VIM TMEM258 DAD1 OSTC CANX CALR ACOT2 YBX1 STT3A EIF4E STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 MAP1LC3B KPNA1 XRN1 IPO7 DNAJB11 PABPC1 P4HA1 UBA52 P4HA2 P4HA3 NPLOC4 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UFD1 RRBP1 UBB EIF4E3 UBC DNAJC3 RPS27A EIF4G3 EIF4G2 SUN2 HSPA8 EIF4A2 EIF4A1 HSPA1A KPNA2 EIF4G1 EIF4A3 ATL2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism MAPDA NT5C2 ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling CAPZA1 PRKCSH AGER LGALS3 S100A12 MAPK1 APP S100B SAA1 HMGB1 CAPZA2 MAPK3 DDOST ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria DCXR NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PCNA YY1 RUVBL1 USP7 ERCC6 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ISY1 ACTR5 RAD23A ACTR8 RAD23B UVSSA TFPT LIG1 POLD3 POLD4 POLK POLD1 POLE POLD2 PIAS3 RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 AQR PARP1 ZNF830 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 PRPF19 RBX1 NFRKB CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 CDK7 ELL ERCC3 ERCC2 MNAT1 ACTB UBB ACTL6A UBC RFC5 RFC3 RFC4 DDB2 RPS27A TCEA1 RFC2 RPA1 ERCC8 RPA2 RPA3 PPIE MCRS1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription IRF1 JUN YAP1 H2BC9 H2AZ2 H4C9 H2BC8 RELA H2BC5 H2BC3 STAT3 TCF7L2 H2BC1 NFKB1 TCF7L1 H2AC20 LEF1 TCF7 CTNNB1 STAT1 ATF3 JUND ASH2L MYCN FOSB MYC TEAD1 TEAD2 TEAD3 TEAD4 SUZ12 DPY30 EPAS1 WDR5 HIF1A EED RBBP4 NFKB2 EZH2 RBBP5 RBBP7 H2AX CREBBP H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 NFE2L2 EP300 H3-3B H3C8 H2AC8 WWTR1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS H2BC11 KMT2A H3C15 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism AADAT SLC3A2 ACMSD AFMID SLC36A4 HAAO KYAT1 TDO2 IDO2 IDO1 SLC7A5 KYAT3 KMO KYNU PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease TALDO1 RPIA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW DPM2 PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions ITGB4 DDR2 DRP2 ITGB5 DMD ITGA6 TNC PDGFB TGFB1 ACTN1 ITGA2 HSPG2 UTRN SNTG2 SDC4 SDC2 SDC3 TRAPPC4 SGCE SGCD AGRN SGCA NTN4 SGCB SGCG SNTA1 SGCZ NRXN1 SNTB1 CASK SNTB2 SDC1 PRKCA LAMA5 LAMA2 THBS1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN DAG1 FGF2 PDGFA TTR DTNA DTNB SSPN DDR1 ITGB3 ITGB1 ITGAV DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes KLF4 FOXG1 SMAD2 SMAD4 SMAD3 PCBP4 FOXO1 CDKN1A CDKN1B CCNG2 MSTN FOXO3 FOXO4 GADD45A CAV1 RBL2 BTG1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ZNF420 CREBBP BBC3 BNIP3L PRELID3A PMAIP1 PRELID1 STEAP3 AIFM2 TP53AIP1 TP53INP1 BAX BID TP63 TP73 PPP1R13B TP53 ATM TRIAP1 TP53BP2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome DDX5 ZCRB1 VHL RB1 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism PLPP2 ACER2 PLPP1 ACER1 ALDH3B2 SGPP2 ACER3 SGPP1 ALDH3B1 SGPL1 PLPP3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation SLC26A2 SRD5A3 GALT B3GALT6 B4GALT7 NCAN HEXB HEXA BGN DCN BCAN VCAN GLB1 CSPG5 CSPG4 GALM ADAMTS13 POMT2 POMT1 POMGNT1 B4GAT1 DAG1 PGM1 LARGE1 GALK1 CHSY1 GALE PRELP CHST6 OMD KERA NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 MUC13 CHST14 HSPG2 MGAT2 PAPSS2 MOGS SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B4GALT1 MAN1B1 GPC1 GPC3 GPC2 GALNT12 GPC5 DPAGT1 SEMA5A GPC4 SPON2 SEMA5B GPC6 SPON1 THSD7B MPI ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 EXT1 ADAMTS3 SDC1 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 THSD7A ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 DPM1 ADAMTS12 DPM2 THSD1 DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 NEU1 SSPOP MUC5B MUC20 MUC21 LFNG ST3GAL3 MPDU1 CTSA NUS1 PMM2 GFPT1 DOLK BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DBT DLD ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense UBC GBP1 RPS27A UBA52 GBP2 GBP6 UBE2D2 GBP4 CASP4 CALM3 CALM2 CALM1 UBB DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants FLT3 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels HCN4 HCN3 HCN2 HCN1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 NEURL1B GZMB UBA52 HES5 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 UBB RBPJ NOTCH2NLA UBC NOTCH2NLC MAML2 NOTCH2NLB MAML1 FCER2 RPS27A MDK EP300 JAG2 JAG1 DLL1 MAML3 NOTCH2 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 HDAC2 KAT8 KDM5B SUZ12 KAT14 SETDB1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SMARCB1 AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 SMARCA2 SMARCA4 KDM6A DNMT3A PBRM1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM SLC34A2 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation HBA2 HBB RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway UBA3 UBE2M CHUK TNFRSF18 RELB MAP3K14 PSMD8 PSMD6 TNFRSF6B PSMD7 EDA TNFRSF13B PSMD2 TNFRSF11B EDA2R PSMD3 TNFSF13B TNFRSF1A PSMD1 TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 PSMA5 TNFSF15 PSMA6 CD70 TRAF2 PSMA3 TNFRSF9 EDAR PSMA4 PSMA1 TNFSF6 TNFSF4 PSMA2 LTA TRAF3 CD27 TNFRSF12A TNFSF9 TNFRSF25 UBA52 BIRC2 TNFSF12 TNFRSF13C TNFSF8 BIRC3 PSMD12 TNFRSF11A PSMD11 CD40LG LTBR LTB PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 TNFRSF1B RPS27A TNF FBXW11 TNFSF13 TNFRSF14 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 APOD SLC27A4 LCN12 LCN1 SLC27A6 LCN9 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 OMA1 PHB2 YME1L1 EIF2AK1 DELE1 EIF2S2 EIF2S1 EIF2S3 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 FURIN IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 SPCS3 ISG15 SPCS2 MED13L SPCS1 CD209 SEC11A SEC11C CDK8 IRF3 IFNAR1 MAVS RIGI TLR2 HSP90AA1 EGFR CD14 RAB5B RAB5C BECN1 TLR7 RAB5A KPNB1 PPP1CC TLR4 BCAP31 STAT2 EP300 LY96 MED1 MED30 MED31 MED8 MED4 MED6 MED7 H2BC15 UBE2L6 HERC5 HSP90AB1 HSPG2 SDC4 SDC2 SDC3 AGRN TLR3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TLR6 ELOB XPO1 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 PPP1CA IFIH1 JAK1 PPP1CB UBB MED16 MED15 CREBBP MED17 UBC MED12 TYK2 MED14 MED13 RPS27A NCL MED10 HSPA8 CUL5 CSNK2A1 CSNK2A2 CSNK2B MED27 MED26 MED23 IGF1R MED25 IFNA5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 CUBN CBLIF AMN LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs FLT3 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBIN HSP90AA1 ERBB2 CDC37 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 GNB5 GNGT1 CCT2 GNGT2 CCT3 TCP1 CCT6B CCT7 GNA14 GNG3 RGS9 GNA15 RGS6 RGS7 GNG2 GNG5 GNG4 GNG7 CSNK2A1 GNA11 GNG8 CCT8 CSNK2A2 CCT5 CCT4 CSNK2B RGS11 GNG10 GNG12 GNG11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER PCNA UBA52 UBB LIG1 UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLE2 POLE3 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 YAP1 HBEGF STAT5A GFAP SPARC STMN1 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 APOE ADAP1 CSN2 NCOR1 CXCL12 MXD4 ESR1 WWOX ADAM17 SRC NRG1 S100B TAB2 EREG NRG3 PGR NRG4 NRG2 BTC ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System YAP1 SEL1L RELA ERLIN1 ERLIN2 ITCH KLC1 RNF185 KLC4 KLC3 KLC2 IFI30 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 KIF5B KIF5A HLA-DOA HLA-DOB LAG3 CTSO CTSF CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG EED RNF111 UBE2V2 RAC1 PRKCB PRKCQ COPS5 UBE2N VAV1 MAPKAP1 NEDD4L CD81 V2-11 DCTN6 V3-4 DCTN5 V3-3 V2-17 DCTN1 DCTN4 V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 CAPZA3 CAPZA2 ACTR10 SOCS1 CD19 IKBKB V2-8 V1-20 MYD88 ASH2L V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 TEAD2 UBE2D2 TEAD3 UBE2D3 TEAD4 ELOB V4-6 ELOC V4-2 RBX1 V4-1 EPAS1 CUL2 HIF1A VHL ICOSLG WWP1 FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B CTSB FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 XDH SIGLEC9 SIGLEC5 WDR5 SEC13 RNF34 RBBP4 RBBP5 PTPRC RBBP7 ITGB2 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 PTPRJ KIF2A ACTR1B CTSH CD33 EVL CTSC KIF2C KIF2B CHUK DYNC1I2 CDC42 PPP2CA KCTD6 PPP2CB LILRA3 DYNC1I1 DYNC1H1 LAIR1 SMURF1 LILRB2 CENPE LILRB3 CD300A OSCAR TYROBP SELL NFKB2 CSK FGB FGA CD274 FGG SYK LCK FYN SKP1 CUL1 CLTC CLTA AP2A1 AP2A2 AP2M1 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 VASP IGHM SH3KBP1 IGHV4-34 IGHV1-2 ITK IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 IGLC3 TRAV29DV5 TRBV7-9 BLNK GRAP2 TRBC1 IGLC1 IGLC2 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 IGKV3D-20 IGHD TRAV19 HLA-DRB4 FYB1 IGKV2-30 ENAH IGLV3-19 HLA-DPB1 IGHV2-70 TRAV8-4 IGHV2-5 HLA-DRA IGLV3-1 LCP2 IGHV3-48 HLA-DRB3 IGLV3-25 HLA-DRB1 IGLV3-27 IGKC HLA-DQB2 IGKV1-39 LAT IGLV3-21 CD101 IGKV1-33 HLA-DQB1 FCGR3A BRD4 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDCD1 PPP3CA PPP3CB LRR1 CCNF UBE2L6 CBLB HERC5 PPP3R1 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 FBXO9 NFATC1 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 DNM2 RNF217 PRKAA1 ATG7 PRKAA2 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 JUND CD207 CALR FBXL4 MLST8 DZIP3 RNF220 FOSB DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 LRRC41 MTOR VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 NCF1 KBTBD6 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 ACTR1A RNF19B UBE3A UBE3B FBXO21 NEK2 UBE2Z FBXO22 NFATC3 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 TRAIP RAB7A RNF41 KLHL42 UBE2V1 DCTN2 CUL7 CUL5 UBA7 UBA6 DCTN3 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 PAK2 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 CARD11 MALT1 ASB13 ASB14 ASB11 RNF6 ASB12 MAP3K14 RNF7 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 PAG1 WAS KIF23 PAK3 COLEC12 KIF20A ITGAV ITGB5 PDCD1LG2 B3GNT3 SPOP SUZ12 DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 GSK3B CD36 KLRK1 NCR2 BCL10 KIR2DS2 CD300LB TREM1 CD300E MAP3K8 KLRD1 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 TAB2 FOS NFKBIB AKT3 JUN PTPN22 CD209 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 UBE2L3 CD14 TLR4 LY96 HMGB1 IRF1 RPN2 TUSC3 RPN1 MAGT1 FBXL18 FBXL7 DNM1 OST4 LGMN DDOST TMEM258 DAD1 OSTC CANX STT3A STT3B KEAP1 DNM3 RNF123 LYN INPP5D PIK3CG PIK3R6 PIK3R5 SIAH2 BTK ARF1 CD40LG JAK1 TRIM4 IKBKG RIPK2 OSBPL1A PIK3CD PRKN CAPZA1 PSME2 PPIA AHCYL1 MAP3K7 VCP CXADR SMURF2 NFKBIA PTEN CD74 JAML CD99 TRAF6 BECN1 PIK3CB CAPZB NCK1 AKT2 CTSD HRAS PDPK1 PIK3CA PIK3R3 PIK3C3 TRIB3 SOS1 SH3RF1 PIK3R4 PIK3R2 PIK3R1 NRAS THEM4 PTPN11 ZAP70 CALM1 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 SEM1 KIF5C KIFAP3 HSPA5 KIF3B KIF3C KIF4B KIF4A TLR1 KIF11 S100A9 S100A8 KIF15 TLR2 KIF22 STX4 CD4 KIF26A TCF7L2 TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ATF3 TREM2 TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 SPTBN2 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CTLA4 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 C3 RICTOR CUL3 STAT1 KIF3A VCAM1 RBBP6 AP1G1 AP1S2 AP1S1 ITGB7 AP1S3 B2M AP1M2 AP1M1 AP1B1 TRIM32 HLA-A TRIM21 CD8B CD28 NEDD4 MKRN1 PLCG1 FZR1 SKP2 CDK4 BLK H2AX H2AB1 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 FBXO32 H2BC1 NFKB1 H2AC20 ITGAL MYLIP TRIM63 ITGA4 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 NCR3 CD200R1 HCST LILRA6 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 CD8A KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 FBXL21P WWTR1 CTSA YES1 CTSV CTSL CTSK DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 IL6 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 IL6R RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway DUSP9 DUSP4 PPP2R5B PPP2R5A DUSP6 PPP2R5D DUSP7 PPP2R5C DUSP10 NRAS UBA52 MAPK1 ARAF PEBP1 RAF1 DUSP16 MARK3 BRAP MAPK3 KSR1 BRAF UBB PPP2R1B PPP2R1A PTPN3 PTPN7 PPP2CA PPP2CB UBC RPS27A PPP5C PAQR3 YWHAB HRAS DUSP5 DUSP2 DUSP1 MAPK12 MAP2K1 MAP2K2 PPP2R5E DUSP8 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling IKBKB UBC TRAF2 RPS27A LRRC14 NLRX1 NLRC5 TRAF6 UBA52 USP14 CHUK TP53 CASP8 USP18 IKBKG UBB IKBIP MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 CPSF4 CPSF7 CPSF1 FUS CPSF3 CPSF2 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 CDC40 DHX9 CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 SYMPK RBM10 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants KIT CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression FASN MLX AGPAT1 ACACA ACLY MLXIPL ACACB EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells CLTC CLTB TIAM1 CLTA AP2A1 EPHB6 EFNB2 AP2A2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 AP2M1 EPHB3 APH1A PSENEN EFNA5 NCSTN EFNA4 APH1B PSEN2 CLTCL1 ADAM10 PSEN1 DNM1 EFNA1 EFNA3 EFNA2 MMP9 AP2S1 MMP2 EPHA2 AP2B1 EPHA5 EPHA4 EPHA7 YES1 EPHA6 RAC1 EPHA8 FYN VAV3 EPHA1 EPHA3 EPHA10 VAV2 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding NTHL1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2BC9 H4C9 H2BC8 H2BC5 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 H2AC1 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 SUZ12 H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 TRIM28 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 RBBP4 EZH2 DAXX NUP37 RBBP7 CBX1 PML H2AC19 H2BC26 DYNC1LI1 H2AC14 DYNC1LI2 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ELK1 ITGB1 H3C15 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type MMAA MMUT IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs IFNG MAPK1 RAF1 JAK2 JAK1 MAPK3 IFNGR1 IFNGR2 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n RFT1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SNAP25 RAB3A ARL6IP5 STX1A SYT1 SLC1A6 GLS2 SLC1A7 VAMP2 CPLX1 RIMS1 UNC13B GLS SLC38A2 PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC17A7 SLC1A1 TSPOAP1 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 RXRB NRIP1 PCK1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway CYP26A1 CYP26B1 CYP26C1 ADH1C DHRS4 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 ALDH8A1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN YES1 HCK SYK FYN ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A8 SLC22A12 SLC22A11 SLC22A7 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOF APOB LPA CETP MTTP P4HB SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea CACNA1D CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 TMIE USH1G STRC MYO15A CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation REXO2 FASTKD5 TBRG4 SLIRP PNPT1 FASTKD2 LRPPRC GRSF1 SUPV3L1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 DYNLL1 DCTN6 DCTN5 ACTR1A DCTN1 DYNLL2 PAFAH1B3 DCTN4 RAB6A CAPZA3 CAPZA2 PAFAH1B1 DYNC1I2 GALNT1 ACTR10 PLA2G4A CAPZB DYNC1LI1 DYNC1I1 RAB6B GALNT2 DYNC1LI2 DCTN2 DYNC1H1 CAPZA1 DCTN3 RAB3GAP2 PAFAH1B2 RAB3GAP1 BICD1 RAB18 BICD2 AGPAT3 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation YARS1 YARS2 NARS1 NARS2 RARS2 CARS1 CARS2 VARS2 MARS2 DARS2 RARS1 SARS2 LARS1 AIMP1 AIMP2 IARS2 QARS1 WARS1 WARS2 MARS1 DARS1 SARS1 EEF1E1 PARS2 KARS1 EARS2 LARS2 EPRS1 IARS1 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 FARSA FARSB FARS2 GARS1 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions CNTNAP1 CNTN1 NRCAM ANK1 SDCBP NFASC DCX TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 HMMR DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TPX2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED BTRC RBBP4 RBBP5 RBBP7 CDK4 H2AX H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DBT DLD DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA PAN3 PAIP1 PABPC1 PARN CNOT4 CNOT6 CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT6L CNOT11 EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 EIF4A3 PAN2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC LDLRAP1 PCCA HLCS CUBN MCCC1 AMN PCCB ACACB NUDT12 ABCD4 NADK SLC2A1 CYB5R3 PRSS3 THTPA TCN1 NMRK2 NMRK1 LMBRD1 NAXE NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MMAB MOCOS FLAD1 SLC22A13 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 QPRT SHMT2 MTRR SLC25A51 PARP10 PARP6 SLC25A19 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR CD38 GPHN PDZD11 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 DCAKD NMNAT1 COASY PPCDC SLC25A16 NUDT8 VNN2 NNMT PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 PNPO AOX1 TCN2 NAMPT CD320 SLC5A6 ACACA CBLIF MMACHC MMADHC FASN BST1 VNN1 GSTO2 SLC46A1 ABCC1 MTR SLC2A3 NAPRT PDXK GSTO1 NADK2 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L SLC5A8 MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP7 PIK3R4 FURIN DDX5 RB1 BECN1 HSPG2 VCP TMPRSS2 SDC4 SDC2 SDC3 AGRN ACE2 CHMP4C CHMP4B GPC1 CHMP4A ZCRB1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 CHMP2B CHMP2A NRP1 SDC1 CTSL VHL PIK3C3 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ILK PARVA ITGB1 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration ACO1 IDH1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes PRDX2 CYCS PRDX1 COX5B COX5A COX6C COX4I1 COX4I2 COX6A1 PRKAA1 COX6A2 PRKAA2 MT-CO1 PRKAG1 G6PD PRKAG2 PRKAG3 RPTOR COX6B2 COX6B1 COXFA4 TNRC6C MLST8 COX7A2 MOV10 RRM2B COX7A1 SLC38A9 HIGD1C AGO3 AGO4 PRKAB2 AGO1 TSC2 AGO2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC YWHAE MT-CO2 PTEN SESN3 MT-CO3 RHEB RRAGB SESN2 RRAGD LAMTOR2 AKT1 LAMTOR1 LAMTOR4 YWHAQ LAMTOR3 LAMTOR5 YWHAG GPX2 YWHAH GPI YWHAZ SFN GLS2 GLS TIGAR TP63 TXNRD1 AKT2 COX7A2L COX7B TP53 COX7C TXN COX8A COX8C AKT3 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CCNH PLK1 CCNB1 CDC25C CDK1 CDC25B FZR1 CDC25A CDK2 CDK7 MNAT1 PPP2R1B PKMYT1 PPP2R1A FOXM1 PPP2CA WEE1 HJURP PPP2CB PPP2R2A SGO1 PPME1 BORA OBI1 MIS18BP1 LCMT1 PPP2R3B TICRR XPO1 CCNB2 CCNA2 CCNA1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 F3 TFPI SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation ACD TINF2 TERF1 TERF2 POT1 TERF2IP STN1 TEN1 CTC1 PRIM2 PRIM1 POLA1 POLA2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB3 KCNN2 KCNMA1 KCNMB4 KCNN1 KCNN3 KCNN4 KCNMB1 KCNMB2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses PTPRS EPB41L3 HOMER3 NTRK3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN RTN3 LRFN3 APBA3 PTPRD APBA2 LRFN2 LRFN4 EPB41L1 LRFN1 STX1A SHARPIN LRRC4B SYT9 GRIA1 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 IL1RAPL2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 DLG1 CASK NRXN2 GRIN2A LIN7A SLITRK2 DLG2 LIN7C SLITRK1 DLG3 SLITRK4 LIN7B SLITRK6 DLG4 PDLIM5 GRIA3 NLGN4Y GRIA4 NLGN4X SYT10 SYT12 APBA1 SYT1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DBNL IL1RAPL1 PTPRF GRM1 GRM5 SLITRK3 SLITRK5 FLOT1 FLOT2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism MCCC2 BTD PC ACACA PCCA HLCS MCCC1 PCCB SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins PIAS4 NFKB2 RELA EIF2AK2 PIAS3 SUMO3 IKBKE NFKBIA UBE2I SUMO1 IKBKG TOPORS UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins HBEGF SNAP25 HSP90AA1 FURIN SYT1 CD9 HSP90AB1 SV2C SV2B SV2A TXNRD1 VAMP1 MAP2K4 STX1A VAMP2 MAP2K7 EEF2 STX1B GUCY2C SYT2 NHERF4 MAP2K1 MAP2K2 CALM1 PDCD6IP DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 NEU1 ALG14 ALG2 ALG3 B4GALT1 ALG13 ALG12 MAN1B1 ALG11 ALG1 MPDU1 DPAGT1 CTSA RFT1 MGAT2 MOGS GLB1 ALG8 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis CSPG4 HSPG2 SDC4 SDC2 SDC3 B3GAT3 XYLT2 AGRN XYLT1 B3GALT6 B4GALT7 GPC1 FAM20B UXS1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 PXYLP1 B3GAT2 B3GAT1 BGN DCN BCAN VCAN SDC1 CSPG5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed SENP5 SUMO3 SENP1 SUMO2 SENP2 SUMO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C8G C5 C6 C7 CLU C9 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism SLC26A2 SLC26A11 SLC26A1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 GNS HAS2 SPAM1 B4GALT6 B4GALT5 B3GALT6 B4GALT7 IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB SLC35B3 B4GAT1 SLC35B2 XYLT2 SLC35D2 XYLT1 FAM20B CHPF PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 B3GNT3 CHST14 HSPG2 PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 ACAN SDC2 SDC3 LUM HS6ST1 B3GAT3 HS6ST2 SGSH CD44 HS2ST1 HS6ST3 NDST2 AGRN NDST1 FMOD EXTL2 NAGLU B4GALT1 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DSEL DSE UST CHST15 ABCC5 ST3GAL4 SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 HMMR ST3GAL2 ST3GAL3 SLC9A1 CTSL CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer HBEGF RAC2 RHOG NTRK3 PIK3R2 NTF3 PIK3R1 PDGFB FGF20 FGF23 MET FGF22 PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 ESR1 ESR2 SRC NRG1 CD28 PIK3AP1 CD86 CD80 ERBB2 EGF PIK3CG EGFR TRAT1 PIK3R6 PIK3R5 KLB FLT3 IRS1 IRS2 PIK3CB STRN FGF1 FGF2 FGF3 PIK3CD AREG FGF4 FGF6 FGF7 FGF9 PDGFRA RAC1 LCK FYN PDGFRB NTF4 NTRK2 BDNF KIT TGFA GAB1 FLT3LG FRS2 HGF GAB2 EREG NRG3 PIK3CA PIK3R3 NRG4 NRG2 VAV1 BTC EPGN NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM SAMHD1 PNP ITPA NT5E ENTPD1 ENTPD5 ENTPD2 ENTPD3 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP3 CHMP6 CHMP7 UBA52 STAM STAM2 HGS VPS36 VPS25 UBB SNF8 UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer SOS1 UBC HBEGF RPS27A HSP90AA1 SHC1 AREG EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN UBB SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE TLR3 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport CYGB MB NGB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses GJA10 PANX1 PANX2 GJD2 GJC1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX ANAPC16 ANAPC7 UBE2C CSF1R VENTX UBE2E1 UBE2D1 RELA ANAPC10 ANAPC11 TCF7L2 CDC23 NFKB1 UBE2S CDC26 CDC27 CDKN2A LEF1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 CCND1 ANAPC2 CTNNB1 CEBPB EHMT2 EHMT1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B IL6 TP53 ANAPC15 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 FGF18 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FGF16 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport TRAPPC6A TRAPPC6B PREB SEC22A SEC22C STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 CTSZ NSF CTSC COL7A1 SAR1B SEC31A TRAPPC4 TMED10 SEC22B TMED2 SERPINA1 SEC23A GRIA1 CD59 F5 TFG F8 SEC24B SEC24A STX5 USO1 ANKRD28 SEC13 PPP6C PPP6R3 NAPA NAPB SEC24D RAB1A SEC24C RAB1B TRAPPC1 GOLGA2 NAPG CSNK1D GORASP1 AREG TRAPPC2L LMAN1L GOSR2 LMAN1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 TGFA SEC16A TRAPPC5 TRAPPC9 YKT6 CNIH1 CNIH2 SCFD1 CNIH3 MCFD2 PPP6R1 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME CYP2E1 ABCG2 GSTT1 GSTM1 ABCC2 GGT5 NAT1 GGT7 NAT2 SULT1A1 GGT6 ABCC5 CNDP2 SULT1E1 SULT1A4 ABCC3 GGT3P UGT1A10 GGT1 ABCC1 SULT1C4 ACY1 SULT2A1 GSTP1 ABCC4 SULT1A3 UGT1A6 UGT1A1 UGT2B15 UGT1A9 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling CSF3 STX4 TYK2 TXLNA CSF1R SNAP25 STX1A IFNLR1 STXBP2 VAMP2 IL34 IL16 PRTN3 IFNL1 SDC1 JAK1 PTPRZ1 IL32 CD4 STX3 IL10RB CSF3R CSF1 CASP3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 INS KIF5C SLC30A8 PCSK1 SLC30A5 STX1A KIF5B KIF5A MYO5A RAB27A VAMP2 MYRIP P4HB PCSK2 ERO1B EXOC8 CLTRN EXOC7 CPE DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 SPAM1 ZP1 B4GALT1 ZP3 ADAM21 ZP2 ADAM20 ZP4 OVGP1 ADAM30 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2E1 PTGR1 ALOX5AP CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions RPS6KA1 CLTC CLTA AP2A1 ITGA1 AP2A2 AP2M1 CNTN1 AP2S1 KIF4B AP2B1 KIF4A NCAN RPS6KA6 LAMA1 EGFR LAMB1 LAMC1 SPTAN1 NUMB SDCBP NFASC RAC1 NRP1 MAP2K1 MAP2K2 EZR ITGB3 ITGA2B SPTBN1 ITGB1 L1CAM VAV2 DPYSL2 ITGAV NCAM1 ITGA5 ITGA9 ALCAM SCN11A RDX SCN10A MAPK1 CHL1 ITGA2 LYPLA2 DNM1 DNM2 MAPK3 CNTNAP1 SPTB RPS6KA4 SCN1B SCN1A ANK2 ANK3 SHTN1 DNM3 SPTBN4 DLG1 SPTBN5 SCN3B DLG3 SCN3A SPTBN2 DLG4 CD24 SCN2A SCN2B KCNQ2 KCNQ3 SCN9A EPHB2 SCN8A ITGA10 SPTA1 CNTN6 RANBP9 SCN5A GAP43 DCX SCN4A SCN4B MSN NRP2 SCN7A CNTN2 NRCAM ANK1 SH3GL2 HSPA8 CSNK2A1 CSNK2A2 PAK1 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 PRKACA SLC8A1 SLC8A2 NOS1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D FXYD4 FXYD3 CAMK2A FXYD2 DMPK FXYD1 FXYD7 FXYD6 ATP2B4 RYR1 ATP2B3 RYR2 ATP2B2 RYR3 ATP2B1 TRPC1 SLC8A3 CLIC2 CALM1 CAMK2G TRDN ASPH ATP1A4 ATP1A3 ATP1A2 TNNI3 ATP1A1 PLN FKBP1B AHCYL1 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 OGG1 NEIL2 POLB LIG3 NEIL1 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation GP5 GP9 F9 GP1BA GP1BB F11 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PRKCA GFRA1 SOS1 GFRA3 GFRA2 SHC1 GFRA4 MAPK7 PIK3R2 PIK3R1 NRTN PLCG1 DOK2 DOK4 DOK5 DOK6 RAP1GAP PRKACG PRKACA PSPN PRKACB GDNF RET PTPN11 IRS2 PIK3CB PDLIM7 PIK3CD DOK1 GRB10 SHANK3 SHC3 GAB1 FRS2 GRB7 GAB2 PIK3R3 PIK3CA ARTN G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG GIP PRKACA PRKACB ADRB2 PTGIR AVPR2 GNAZ LHB PDE1B ADORA2B GNG3 PDE1A GNG2 RXFP1 GNG5 RXFP2 GNG4 GNG7 PDE11A GNG8 PDE2A ARRB1 ARRB2 PTH1R GPR39 PDE10A PTH2R GPHA2 GNAS NPSR1 CRH NPS GPHB5 LHCGR RLN2 RLN3 P2RY11 GCGR GCG INSL3 GPR84 PTH2 CRHR1 CYSLTR2 RAMP2 CALCA MC1R RAMP3 CALCB PDE3B MC4R CALCR CALCRL GPBAR1 MC3R ADM2 ADM IAPP FSHR GRK5 RAMP1 PTH MC5R PRKAR1B PRKAR2B PRKAR1A PRKAR2A ADRB1 HTR4 ITGB1 GPER1 HTR6 TAAR3P ITGA5 HTR7 CGA HRH2 DRD1 DRD5 PTHLH TAAR8 TSHR TAAR9 TAAR6 GNAT3 TAAR5 TAAR2 FSHB TAAR1 ADRB3 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PDE3A PDE8B PTGER4 PDE8A GRK3 GRK6 SRC ADCYAP1 PTGER2 ADCYAP1R1 PTGDR PDE4A PDE4D PDE4C GNAI3 ADORA2A GNAI1 GNAI2 PDE7B PDE7A CRHR2 TSHB POMC GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP AVP GRK2 GNG10 MC2R GNG12 GNG11 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) STAT5A STAT5B UBE2D1 SHC1 LYN STAT3 GRB2 UBA52 JAK2 JAK1 STAT1 KRAS SOCS1 UBB PTPN11 CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC GAB2 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNQ1 KCNE5 AKAP9 KCNH2 KCNE1 KCNA5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 FGF6 FGF9 PLCG1 FGF20 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 PPP2CA PPP2CB CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C AKT2 CTLA4 YES1 LCK FYN AKT1 PTPN11 PPP2R1B PPP2R1A PPP2R5E AKT3 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels STIM1 P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 P2RX4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling FGF2 TGFBR3 GIPC1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB ENSA MASTL PPP2R2D CCNB1 PPP2R1B CDK1 PPP2R1A ARPP19 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 SFTPD IL17RC IL17RA NLRP12 YWHAQ IL17F IL17A YWHAG GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 STAT2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E IKBKB YWHAB TRIM25 IKBKE AKT1 IRF7 NUP214 SFN YWHAZ IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C NUP42 NUP85 TPR NUP62 UVRAG NUP88 MAP1LC3B NUP43 RAE1 HSP90AA1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 NOD1 NOD2 AKT2 PDPK1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 TJP1 CHUK PTPN11 SIKE1 CREBBP PTPN6 IRAK2 SNRPG TAB3 TAB2 SNRPE IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria KHK MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT11 ACADL ACOT12 HADHB ACOT13 HADHA ACADVL ACADM ACSM3 ACADS PCCA ECI1 THEM4 PCCB ACSM6 THEM5 ACAD11 NDUFAB1 ACAD10 MCAT ACBD7 ACBD6 ACOT7L ACSF2 MCEE ACOT2 DBI PCTP ECHS1 DECR1 ACOT9 ACOT7 MECR ACAA2 MMAA MMUT HADH ACOT1 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 LMNB1 UBE2I TEX12 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B REC8 SYCP3 BRCA1 STAG3 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L H2BC21 SUN2 SUN1 H2AC8 H2AC6 H2AC7 H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 STAG1 H2BC11 STAG2 RAD21 ATR DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis RIPK1 TRADD TRAF2 RIPK3 CASP8 FADD MLKL DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) RELA NFATC1 MAP3K7 NFKB1 NRAS RASGRP1 NFATC2 CHUK IKBKB CARD11 MALT1 NFKBIA FKBP1A PSMD8 PSMD6 PSMD7 RASGRP3 PSMD2 REL NFKBIE PSMD3 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PPIA PSMC5 PSMC6 HRAS PRKCB SEM1 PSMC3 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB SKP1 NFKBIB PPP3R1 CUL1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2BC9 H2AZ2 H4C9 H2BC8 PIWIL2 H2BC5 TDRKH H2BC3 PIWIL1 HENMT1 H2BC1 ASZ1 MAEL MOV10L1 MYBL1 H2AC20 TDRD9 TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 DGCR8 TNRC6C TSNAX AGO3 PRKRA DICER1 AGO4 TARBP2 TSN AGO1 AGO2 TNRC6A TNRC6B POLR2A POLR2B POLR2C HSP90AA1 POLR2D POLR2E RAN POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L IPO8 ELAC2 H2AX H2AB1 H2AC19 H2BC26 ANG H2AC14 BCDIN3D H2BC12L XPO5 H2BC21 DROSHA PIWIL4 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 POU3F2 TNRC6C MOV10 AGO3 DICER1 AGO4 HDAC1 TRPM1 AGO1 AGO2 TNRC6A TNRC6B HINT1 BIRC7 BCL2A1 SIN3A PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 PLCG1 FGF20 FGF23 KLB FGF16 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs MAP1LC3B ULK1 RAB8B RAB33B RAB33A TBC1D2 RAB5B RABEP1 RAB5C TBC1D3 TBC1D7 RAB7B RABGAP1 RAB11A RAB6A ARF6 RAB4A RAB11B RAB5A RABGEF1 TBC1D10A TBC1D10B GABARAPL2 SYTL1 RAB7A RAB6B RAB35 GGA2 TBC1D24 GGA1 TBC1D25 OPTN GGA3 TSC2 RAB8A TSC1 TBC1D20 GABARAP TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 TBC1D10C CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC2A6 SLC2A7 SLC5A1 SLC2A8 SLC5A2 FGF21 SLC50A1 SLC2A4 SLC2A9 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A10 SLC2A11 SLC2A12 SLC5A10 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D GRIN1 RPS6KA6 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 RPS6KA3 RPS6KA2 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion UBC RPS27A FURIN VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A PPIA VPS37B MVB12B MVB12A UBAP1 NMT2 UBB PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG CETP APOA2 APOA1 APOA4 APOA5 APOE ANGPTL8 ANGPTL4 LPA MTTP LPL LMF2 LMF1 APOF GPIHBP1 FGF21 MBTPS1 APOC3 APOC2 ANGPTL3 ALB P4HB ABCG1 MBTPS2 APOB PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL PPP2CA PPP2CB PECAM1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PTPN6 MAPK14 LRP8 APOB PLA2G4A PTPN11 PPP2R1B FGR PPP2R1A PPP2R5E BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 ABCA3 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases RNF128 APC OTUD5 UBE2D1 TRAF3 ZRANB1 TRAF6 UBA52 OTUB1 RHOA CDK1 OTUB2 OTUD7A OTUD7B VCP IFIH1 NOD1 TRIM4 NOD2 VCPIP1 IKBKG UBB RIPK2 RIPK1 UBC RPS27A ESR1 TNIP1 MAVS TNIP2 TNIP3 OTUD3 RNF135 RIGI PTEN TNFAIP3 TP53 TRIM25 YOD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CYP51A1 SREBF2 MSMO1 NSDHL HSD17B7 TM7SF2 SREBF1 DHCR24 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome RELA NFKB1 HSP90AB1 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 PYCARD NLRP3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 PIP4K2C IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport ATP6V0D1 FTH1 ATP6V0C ATP6V0D2 ATP6V1B1 FTL ATP6V1A IREB2 ABCG2 CP FBXL5 ATP6V0A2 CYBRD1 ATP6V1H ACO1 ATP6V0A4 SLC40A1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HEPH ATP6V1F ATP6V1C2 ATP6V0A1 TF SLC46A1 STEAP3 HMOX1 HMOX2 SLC22A17 FTMT MCOLN1 STEAP4 TFRC HFE GLRX3 UBA52 UBB TCIRG1 CAND1 UBC LCN2 RPS27A NEDD8 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 SKP1 TFR2 ATP6V1B2 SLC11A2 CUL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 CRK PXN ARHGAP35 RASA1 NRAS RHOA ELMO1 RAC1 HRAS BCAR1 ELMO2 DOCK1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling CCND1 RUNX3 CTNNB1 TCF7L2 TCF7L1 MYC LEF1 TCF7 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 GRAP2 RICTOR MAP3K8 PPP2R1B PPP2R1A PIK3CB CDC42 PPP2CA PPP2CB MLST8 PIK3CD AKT2 CTLA4 MAP3K14 YES1 PAK1 PAK3 MTOR RAC1 LCK CD28 FYN PRR5 PDPK1 PAK2 AKT1 PIK3R3 PIK3CA VAV1 MAPKAP1 PPP2R5E AKT3 TRIB3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA RPS6KA1 SOS1 CCKBR HBEGF MAPK7 EGFR NRAS MAPK1 HRAS MMP3 MAPK3 GAST RPS6KA3 RPS6KA2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants FZD5 FZD4 WNT3A FZD6 LRP5 RNF43 FZD8 LRP6 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle LIG1 BANF1 XRCC6 FEN1 XRCC4 KPNA1 XRCC5 LIG4 PPIA HMGA1 CCR5 CXCR4 PSIP1 CD4 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E UBC RPS27A UBA52 UBB MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling RANBP10 HRAS SOS1 MUC20 MET RANBP9 HGF NRAS CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA1 NRAS MAPK1 MAPK3 RASGRF2 CAMK2B CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 RPS6KA6 PDPK1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RPS6KA3 CALM1 CAMK2G RPS6KA2 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX10 PPOX ALAS1 CPOX HMBS ABCG2 ALB UROD UROS ALAS2 COX15 ALAD FECH ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase CREBBP HSP90AA1 HSPA8 EP300 HSP90AB1 DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A FKBP4 HSPA1B SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins SOS1 STAT5A STAT5B CDKN1A PIK3R1 NRAS TRIP11 GOLGB1 PIM1 HRAS ZMYM2 GAB2 MYO18A PIK3CA ETV6 NOX4 SPTBN1 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH GNMT DAO PXMP2 GLDC AGXT HOGA1 GOT2 KGD4 GRHPR DDO HAO1 AGXT2 AMT DLST ALDH4A1 PRODH2 DLD FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate POU3F1 PAX6 ZIC2 ZEB2 SOX2 POU5F1 NANOG ZNF521 SOX1 GBX2 OTX2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN RNF146 PSMA5 PSMA6 PSMA3 PSMA4 AXIN2 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 TNKS PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A SMURF2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 AXIN1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT5 NUDT16 NUDT15 ADPRM NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling RGMB RGMA UNC5A UNC5B PLCG1 SIAH2 UNC5C UNC5D PITPNA AGAP2 WASL HJV SIAH1 PTPN11 CDC42 SLIT1 SLIT3 NEO1 DSCAM NTN4 MYO10 DCC DSCAML1 NTN1 TRIO NCK1 SLIT2 ROBO1 SRC RAC1 TRPC7 TRPC5 TRPC6 PRKCQ ABLIM1 TRPC3 ABLIM2 TRPC4 ABLIM3 TRPC1 PTK2 EZR DOCK1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A SS18 SMARCB1 SMARCD1 DPF1 BCL7A DPF2 BCL7C SMARCA2 BCL7B DPF3 SMARCA4 SMARCC1 SS18L1 ARID1A SMARCE1 ARID1B ACTB SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane SRPRB SEC61A2 SEC61A1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TRAM1 RPS3A RPS26 SRP54 RPS25 RPS28 SSR4 RPS29 SSR2 RPS20 SSR3 SRP9 FAU RPS21 RPS24 RPS27 RPS23 SRP72 SRP68 SRP19 RPN2 RPN1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL DDOST RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 SRP14 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 SEC61G RPLP0 SEC61B RPS27A SSR1 SRPRA SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A2 SLC17A1 SLC26A11 SLC4A7 SLC26A1 SLC20A2 SLC4A8 SLC4A10 SLC4A9 SLC26A4 SLC26A7 SLC26A3 SLC26A9 SLC26A6 SLC13A1 SLC13A4 AHCYL2 SLC12A3 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC4A2 SLC12A7 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 SLC12A6 SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC5A5 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin MAOA SLC6A4 ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME MAPDA NT5C2 ABCB1 ADH1A PCK1 ABCG2 SLC22A2 SLC22A3 SLC22A1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism CDA ADSL PPAT GMPS NUDT13 ADSS1 ADSS2 GART PAICS PFAS NT5C DCTPP1 AGXT2 NT5C1A DPYS NME2 DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP RRM1 RRM2B SAMHD1 DTYMK ATIC ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 TK1 ENTPD8 AK1 RRM2 AK2 NME1 AK4 AK5 AK6 AK7 AK8 AK9 GLRX NME3 NME4 DCTD CMPK1 TXNRD1 TYMS CTPS2 MAPDA CTPS1 GMPR2 GDA ADK AMPD1 NT5C2 NUDT5 GMPR DNPH1 AMPD2 AMPD3 NT5C1B NUDT16 DCK NUDT15 APRT ADPRM DGUOK PNP ITPA HPRT1 IMPDH1 IMPDH2 ADA UCKL1 UCK2 UCK1 PUDP TK2 NT5E ENTPD1 ENTPD5 TXN CAD DHODH UMPS GUK1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 STX1A SYT1 VAMP2 SV2C SV2B SV2A VAMP1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival IKBKB SQSTM1 UBC RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR UBB HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 MFN1 MFN2 KLC1 KLC4 IFNA10 KLC3 GUCY1B2 KLC2 GUCY1B1 IFNA21 ATP2A3 ATP2A2 IFNB1 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PLA2G4A FGR STIM1 KCNMA1 ORAI2 SLC16A8 PECAM1 ORAI1 SLC16A3 PDE9A PDE1B PDE1A KIF5B ITPR1 KIF5A ITPR2 SLC16A1 ITPR3 SRI PSAP LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS2 NOS3 PDE2A ATP2B4 VPS45 ATP2B3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 P2RX4 PDE10A P2RX3 CRK P2RX2 P2RX1 GNAS SERPINB8 S100A10 C1QBP CABLES1 RAB5A MMP1 SLC3A2 SLC7A11 EPCAM SLC7A10 PRKCB SERPINC1 RAC1 VAV3 SERPIND1 PRKCQ SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 VAV2 SLC7A9 IRF1 IRF2 NFE2 V2-11 V3-4 V3-3 MPL V2-17 THPO V3-2 V2-15 V2-19 V1-11 GNA13 V1-16 V1-13 CAPZA2 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 TBXA2R V4-6 V4-2 V4-1 SDC1 GATA3 LYN INPP5D PIK3CG PIK3R6 PIK3R5 CFL1 PF4 SERPINB2 ANXA2 MIF SOD1 CAPZA1 AAMP PPIA TUBA4A PRKCG TP53 PRKCE GNG10 GNG12 GNG11 GNG13 ITGA3 GNB2 GNAQ ITGA1 GNB1 MAFG ITGA6 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 WEE1 GNA14 OLR1 SPN VPREB3 VPREB1 GNG3 CXADR CDK5 GNA15 PSG1 PDPN PSG3 MPIG6B GNG2 SERPINB6 CLEC1B PSG2 GNG5 PSG9 GNG4 FCAMR GNG7 PSG8 GNA11 PSG5 GNG8 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 ARRB1 ARRB2 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD SH2B2 ANGPT4 ANGPT2 MERTK CD2 CD244 ITGAM ITGB2 PPP2R1B PPP2R1A PIK3CB CAPZB PRCP PFN1 GATA6 TFPI F13B HRAS PCDH7 ZFPM1 PDPK1 RBSN SIRPG GRB7 KIF18A PIK3CA PIK3R3 ITGB1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 NRAS GP1BA RHOA HBB RHOB KIF2A MAPK1 KIF2C KIF2B FCER1G CEACAM3 MAPK3 PTPN1 PTPN11 CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA PPP2CB CD58 ITPK1 CENPE DGKG SRC DOCK5 DGKE ACTN2 DOCK4 DAGLA DGKD DOCK3 DGKB DGKA ABHD6 ABHD12 PLAU PRKCH DGKZ SIRPA DGKQ DAGLB DGKK DGKI DGKH CALM1 DOCK2 DOCK1 VEGFB VEGFC VEGFD THBS1 VEGFA SELL GNA12 CSK JAK2 FGB FGA VWF PLAUR FGG APBB1IP TLN1 VCL CEACAM1 SYK RAD51B LCK FYN F7 APP F9 F13A1 RAD51C POTEKP PROC ISLR F10 LAMP2 PROS1 HABP4 FAM3C CHID1 F2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 KIF28P TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 KIF5C PDGFB A1BG CLU KNG1 KIF21A CYB5R1 KIF21B RASGRP2 KIFAP3 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A PRKACG RARRES2 IGF2 RAF1 IGHV3-23 PRKACA RAB27B PRKACB IGF1 RAPGEF3 PPBP IGLV CYRIB RAPGEF4 IGLV2-8 MANF SELP IGKV1-16 TF KIF16B IGKV1-17 SCCPDH IGKV1-12 KIF20B CALU IGHV3-7 MAGED2 IGHV3-9 HRG IGHV3-30 FERMT3 LGALS3BP IGHV3-33 SERPINA3 KIF3B IGKV1D-39 A2M ORM1 IGKV1D-33 ECM1 SERPINA1 KIF3C WDR1 IGKV2D-28 PLEK IGKV4-1 OLA1 KIF18B IGHV7-81 CTSW KIF4B ORM2 SERPINA4 IGKV2D-30 KIF4A TMSB4X IGHV4-59 ALB IGHV1-69 PHACTR2 KIF12 TIMP3 PHF21A KIF11 QSOX1 PRTN3 TIMP1 IGLV2-11 SRGN IGLV1-40 CAP1 IGLV1-47 TRPC7 KIF15 ABCC4 AHSG KIF19 IGLV6-57 ANXA5 IGLV2-14 F5 IGLV1-44 TRPC6 KIF13B PLCG2 F8 TRPC3 KIF1C IGKV3-15 MMRN1 KIF1B TOR4A IGKV3-11 IGKV2D-40 CD63 IGHV3-11 ITIH4 KIF1A IGHV3-13 ITIH3 PLG IGLV7-43 IGKV1D-16 TTN IGKV1D-12 CLEC3B KIF25 IGLV1-51 CDC37L1 SPP2 IGLV2-23 KIF22 STX4 RCOR1 KIF6 LEFTY2 IGKV3-20 IGHM KIF27 LY6G6F LHFPL2 PCYOX1L IGHV4-34 IGHV1-2 KIF9 CD9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 FLNA IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 HMG20B PPIL2 IGLC1 IGLC2 F2RL2 ADAMTS13 F2RL3 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 F2R IGKC LAT IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 KIF26A IGLC6 IGKV1-5 KIF26B PRKAR1B PRKAR2B PRKAR1A PRKAR2A P2RY12 P2RY1 HDAC1 ACTN1 SIN3A CDK2 ADRA2C ADRA2B F3 ADRA2A SH2B3 AKT1 SERPINE2 GATA4 JMJD1C GP1BB GATA1 F12 HBE1 PRKCD F11 ZFPM2 PRKCA GATA5 GP5 SERPINA5 AK3 YWHAZ GP9 MICAL1 KLKB1 CARMIL1 HBG2 HBG1 EHD1 EHD2 EHD3 MAFF HBD AKAP10 DOCK10 DOK2 AKAP1 SH2B1 CABLES2 GP6 ITGA10 MAPK14 RACGAP1 CAV1 CFD JAM2 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 KIF3A PDE5A DOCK11 EGF PLCG1 DOCK6 DOCK9 DOCK8 DOCK7 PLAT MYB H3-3B F11R H3C8 PRKCZ KIF23 BCAR1 KIF20A ITGB3 ITGA2B GATA2 L1CAM H3C15 ITGAV ITGA5 BRPF3 TNFRSF10B SPARC TNFRSF10A SERPINE1 TNFRSF10D ITGAX KDM1A GNAT3 ITGA2 ITGAL TGFB2 TGFB3 ITGA4 TSPAN7 MGLL HDAC2 PICK1 GNAI3 GNAI1 CBX5 GNAI2 CD36 ALDOA TREM1 MAFK PTPN6 YES1 BSG IGHA1 PTK2 IGHA2 IFNA5 IFNA4 IFNA7 JCHAIN IFNA6 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress JUN CCAR2 DNAJC2 DNAJC7 CXXC1 COX5B RPS19BP1 HSPA4L COX5A HSPA14 RELA HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 COX6C HSPA7 HSPA12A HSPA12B IFNB1 COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM IL6 APOB YWHAE GSK3A CDKN2D EED CDKN2C PDIA6 DNAJB11 CAT IGFBP7 WFS1 SOD2 CARM1 IL1A FBXL17 BACH1 PRKCI TLR4 DNAJC3 SLC7A11 LY96 MED1 OMA1 PRDX2 PRDX1 MAPK7 ADD1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 ATF6 DNAJA4 CRYAB DNAJA2 MAP3K5 CAPZA2 FKBP4 DELE1 HERPUD1 ACTR10 HSPA1B MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 SQSTM1 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 UBE2D2 UBE2D3 HIF3A KEAP1 LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 AR EGLN2 WTIP CDKN2B NPLOC4 NRF1 RPLP0 UBXN7 DPP3 HSPA9 UFD1 TALDO1 SOD1 CAPZA1 CSNK2A1 FKBP14 IGFBP1 GPX1 GOSR2 CSNK2A2 MYDGF EXTL1 TATDN2 LMNA SSR1 CSNK2B DNAJB9 SULT1A3 TSPYL2 ZBTB17 TP53 KLHDC3 DDX11 WIPI1 PGR YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB FKBP5 TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP MAP2K6 PRDX6 NLRP3 ESR1 CLEC1B MDM2 MDM4 GSTP1 NUP205 POM121 HMOX2 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 SMARCD3 NUP133 NUP210 HMGA1 NUP153 NUP93 HDAC6 NUP50 NUP35 RBBP4 NUP54 NUP37 RBBP7 STIP1 TXNRD1 TCIRG1 DYNC1LI1 CAPZB DYNC1LI2 AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 COX7A2L TXN RPS27 ATP6V1B2 EPO TRIB3 ATP6V0D1 CITED2 ATP6V0C ATP6V0D2 VENTX PPP2R5B ATP6V1B1 ATP6V1A SHC1 DYNLL1 ABCG2 DYNLL2 HBB ATP6V1H MAPK1 ATP6V0E2 NFYA ATP6V1G3 NFYB NFYC ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 DYNC1I2 BMAL1 MAPK3 COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A HM13 EIF2AK3 NOX4 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 HSPA6 UBE2D1 HSPE1 ANAPC10 HSPD1 ANAPC11 VEGFA CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN TLN1 RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 SKP1 CCNA2 ATM CCNA1 ATR CUL1 CXCL8 CREB3L3 NUDT2 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 HSPA5 HSBP1 CHD6 GPX3 HSF1 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 DEFA5 BTRC RPS4Y2 RPS27L RPS4Y1 ATOX1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A STOML2 RPS16 GCN1 WDR59 RPS19 PHB2 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT YME1L1 RPS10 DEPDC5 RPS13 KPTN WDR24 RPS12 RPS9 SH3BP4 RPS7 FNIP1 RPS8 FNIP2 RPS5 KICS2 CASTOR1 RPS6 CASTOR2 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 CDKN1A CDKN2A HSP90AB1 SIN3A CDK2 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS PRKAA2 SEC31A EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 RPTOR ATF3 ATF4 TNRC6C CALR MOV10 MLST8 SLC38A9 ID1 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 TXNIP HMOX1 RRAGC MT-CO2 PSMD7 MT-CO3 RHEB RRAGB XPO1 PSMD2 RRAGD KHSRP AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 NUP214 LAMTOR5 DIS3 IDH1 PRKCD NCF1 PSMA5 NCF2 PPARGC1A PSMA6 NCF4 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 ACTR1A DCP2 SERP1 PSMD12 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 CYBB PSMB4 EXOSC5 CYBA PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 CUL7 HSPA8 DCTN2 ADRM1 DCTN3 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PGRMC2 PSMC4 PSMC1 PSMC2 SIRT1 HSPA1A SIRT3 PPARA CYCS HMGA2 H1-1 H1-0 H1-3 CUL3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A TRIM21 HSPH1 HYOU1 HBA2 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 HIGD1A H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 HSP90B1 KDM6B H3C15 RXRA ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 STAT3 H3-4 H2BC1 POT1 NFKB1 TERF2IP H2AC20 RPL4 RPL5 HDAC3 RPL30 RPL3 RPL32 RPL31 RPLP1 NRIP1 RPL34 RPL10L COX4I1 RPL8 COX4I2 RPL10A TBL1X RPL6 RPL7 NCOA1 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 NCOR2 ARNT RPL39 RPL21 RPL23 NCOR1 RPL22 BMI1 TBL1XR1 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RNF2 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 CRTC2 CRTC3 CRTC1 CLOCK MAP2K3 NPAS2 HELZ2 MAP2K4 RAI1 CREBBP MAPKAPK3 SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 TGS1 MEF2D MAP2K7 MAPK10 COX7B FOS GFPT1 FOXO3 COX7C EDEM1 SYVN1 COX8A COX8C AKT3 HIKESHI KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB MECR HADHA ECHS1 ACADM HADH SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs NTRK1 KIDINS220 SOS1 CRK SHC1 NGF MAPKAPK2 NRAS RALA MAPK1 RAP1A MAPK3 BRAF RAPGEF1 MAPKAPK3 MAPK14 MAPK11 YWHAB SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 FRS2 RIT1 MAP2K1 RIT2 CRKL MAP2K2 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection SNRNP200 HDLBP SRSF6 KDELR1 SRSF7 AP2A1 SNRPB AP2A2 SRSF9 DDX5 BAG2 PRPF8 AP2M1 CLU CPSF4 CPSF1 APOA1 HSPA5 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 PRKG2 CD209 RTN3 CHERP ISY1 AP2S1 DDX46 DDX42 YBX1 PTBP1 AP2B1 HAVCR1 BCAS2 P4HB RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 IPO7 PUF60 DNAJB11 U2AF2 P4HA1 P4HA2 SNRPB2 CD14 P4HA3 SMNDC1 DNAJC10 NMT1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 KPNB1 PPIL3 PPIL4 TLR4 DNAJC3 HNRNPA1 STAT2 LY96 RPSA MAPKAP1 PDCD6IP FASN C4BPA C4BPB RPN2 TUSC3 ATG14 RPN1 HSP90AB1 MAGT1 CTNNB1 DNAJA2 C4B_2 OST4 SDC4 ATG7 HSPA1B SDC2 DDOST SDC3 TMEM258 RPTOR DAD1 OSTC CALR CANX ACOT2 MLST8 STT3A STT3B EIF4E GPC1 GPC3 UBE2I GPC2 MRC1 GPC5 SUMO1 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 XPO1 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D XRN1 LYN POLR2E POLR2F POLR2G PABPC1 POLR2H UBA52 POLR2I POLR2J NPLOC4 POLR2K POLR2L H2AC25 NEK2 H2AC21 PDIA3 GTF2F1 CLDN1 GTF2F2 IFIH1 UFD1 UBB UBC RPS27A HSPA8 UBA7 UBA6 UBA5 UBR4 NRBP1 HSPA1A KPNA2 EIF4G1 PEX19 RNASEK ATL2 LY6E KPNA7 NACA KPNA4 HNRNPA0 TIMD4 KPNA5 CD2BP2 KPNA3 HNRNPUL1 TYRO3 BTF3 FURIN AUP1 UBA3 PPIL6 MAPRE3 EMC4 UBA1 ELAVL2 RICTOR H2AC1 CPSF7 SPCS3 SRRM1 SPCS2 VCP CLINT1 SPCS1 SEC11A SEC11C VIM HNRNPC RIPK1 RBMX STING1 NFKBIA SCAP MAVS HYOU1 CLEC5A MAP1LC3B HSP90AA1 KPNA1 H2BC18 MERTK BECN1 DAXX EIF4E3 H2AC19 AXL H2BC26 H2AC14 EIF4G3 EIF4G2 H2BC21 SUN2 TSG101 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 PIK3R1 CDC40 H2AC20 DHX9 HSPG2 CD33 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 CD300A HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 DPM1 SF3A1 DPM2 SF3A2 DPM3 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 RRBP1 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN NCL WBP11 PRPF6 SNRPG SRSF2 PROS1 PPIE NFKBIB SRSF3 F2 SNRPE GAS6 SRSF4 SNRPF SRSF5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases MMP15 COL18A1 MMP17 KLKB1 FURIN CMA1 ELANE CTSG PRSS2 MMP8 MMP9 KLK2 MMP25 MMP1 TIMP2 MMP2 PRSS1 CTRB2 SPOCK3 CTRB1 TIMP1 MMP3 CTSV MMP24 TPSAB1 MMP7 MMP13 CTSK MMP10 PLG MMP11 MMP14 MMP16 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling SOS1 CRK SHC1 FN1 RASGRP2 RASGRP1 RAP1B RAP1A CSK FGB RAPGEF3 FGA RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 AKT1 PTK2 ITGB3 ITGA2B METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY CBS MAT1A NNMT GNMT CTH SCLY HNMT SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport SLC10A6 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C CAMK4 GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL CALM1 CAMK2G ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D GNS CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CYSLTR1 CCL2 EDNRA OPN3 CCL1 RRH EDNRB CCL19 PTGIR PROK2 CCR2 RGR CCL17 AVPR2 PROK1 AVPR1A CCL16 OPN5 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 LPAR4 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 GPR17 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP LPAR6 CMKLR1 NMS PDYN NMU AGTR2 GNRH2 FPR3 GNRH1 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 GPR132 CCKAR GNRHR GPR183 FFAR4 PNOC FFAR3 GPR18 FFAR2 SSTR3 GPR39 EDN1 GPR37 ANXA1 EDN2 GPR35 EDN3 GPR31 CCKBR GPHA2 NPSR1 GRP GPR55 PTAFR NPS GPHB5 PLPPR1 PROKR1 LHCGR PLPPR2 PROKR2 MTNR1A PLPPR3 KISS1R MTNR1B MCHR1 PLPPR4 P2RY10 RLN2 PLPPR5 P2RY11 RLN3 LPAR1 ECE1 LPAR2 GPR4 ECE2 LPAR3 PRLHR LPAR5 MT-RNR2 INSL3 F2RL1 CHRM2 INSL5 S1PR1 PENK F2RL2 CHRM3 S1PR3 F2RL3 CHRM1 S1PR2 APLN GPR37L1 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 KEL PMCH NLN CYSLTR2 PPY MC1R GHSR MC4R OXGR1 F2R GPBAR1 LTB4R2 MC3R UTS2 GAL NTS FSHR MCHR2 NPB OPN4 NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R LTB4R NPY1R APLNR SUCNR1 BDKRB2 HCAR2 BDKRB1 HCAR3 QRFPR GNRHR2 HCAR1 XCL2 XCL1 PYY HTR2B HTR2C HEBP1 ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 ADORA3 ADRA1A CCK ADORA1 HRH1 GPER1 HCRTR2 HTR6 HCRTR1 TAAR3P NPY5R KISS1 HTR7 SSTR1 CGA HRH3 SSTR2 HRH2 HRH4 SSTR4 DRD1 SSTR5 DRD2 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 DRD5 HTR1E CNR2 TAAR8 CNR1 HTR1F TSHR TAAR9 OPRD1 ACKR1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 FSHB ADRA2C C5AR2 HTR5A ADRA2B TAAR1 C5AR1 ADRA2A GPR143 C5 ADRB3 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR ADORA2A AGT TSHB PF4 C3 FPR1 FFAR1 ADRB2 OPN1LW LHB ADORA2B OXER1 OPN1MW RHO NPY CXCR1 CXCR2 OPRM1 SST OPN1SW OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis MUC15 MUC13 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC3 MUC1 ST6GALNAC4 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 MUC12 ST6GAL1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX F9 F10 F8 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria BID CASP8 GZMB NMT1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling RPTOR EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B YWHAB RPS6 MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation KPNA1 H1-1 H1-0 DFFB H1-3 DFFA HMGB2 HMGB1 H1-2 H1-5 H1-4 KPNB1 CASP3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) PCNA POLH MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR FIGNL1 UBA52 FIRRM BLM MRE11 RTEL1 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 RFC5 UBC RMI2 POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE RMI1 POLD2 RFC2 RFC1 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C POLE4 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 POLE2 POLE3 ATR RAD9A RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy MAP1LC3A FUNDC1 ATG5 CSNK2B MAP1LC3B ATG12 ULK1 CSNK2A1 CSNK2A2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH12 RDH8 RBP1 LRAT STRA6 TTR RDH5 RLBP1 RDH11 ABCA4 RDH10 RDH16 SDR9C7 RPE65 RHO MYO7A DHRS9 CYP4V2 RBP3 HSD17B6 HSD17B1 RBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 HSP90AB1 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSBP1 PTGES3 HSF1 HSPA2 CRYAB VCP FKBP4 MAPK3 HSPA1B RPTOR MLST8 CAMK2B HSPB8 CAMK2D HSPH1 CAMK2A MTOR YWHAE NUP205 AKT1S1 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C CAMK2G NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 HSP90AA1 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 NUP37 HSPA9 CREBBP EP300 HSPA8 RPA1 RPA2 EEF1A1 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes NCAPH CSNK2B SMC4 SMC2 CCNB2 CCNB1 NCAPD2 CSNK2A1 CDK1 NCAPG CSNK2A2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G IQGAP1 FAM114A2 QKI KIAA1549 ESRP1 TRIM24 FXR1 FN1 AGTRAP ARAF AP3B1 PEBP1 CSK AGGF1 JAK2 TENT4A MARK3 FGB FGA VWF KSR1 FGG BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation NR1H2 CLTC PCSK9 NR1H3 UBC AP2S1 CLTA AP2A1 VLDLR RPS27A AP2A2 AP2B1 UBA52 AP2M1 MYLIP UBB DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME UGT2B7 SLCO1B1 SLCO1B3 GSTA1 ABCC2 XDH GGT5 GGT7 GGT6 CNDP2 GGT3P GGT1 SLC16A1 ALB ACY1 SLC22A3 GSTP1 ABCC4 CES1 SLC22A2 SLC22A1 CYP2C9 CYP2C8 CYP2C19 MAPDA ADK AKR1C1 PNP CYP2D6 HPRT1 SLC22A7 IMPDH1 ADA IMPDH2 SULT2A1 CES2 SLC28A2 RAC1 SLC29A1 VAV3 SLC29A3 SLC29A2 SLC28A3 VAV1 VAV2 CYP2E1 HSD11B1 ABCG2 HSD11B2 GMPS TPMT GSTT1 UGT1A3 PCK1 GSTM1 NME2 SERPINA6 SULT1A1 SULT1E1 ACSM2B SULT1A4 ABCC3 ABCC1 SULT1C4 BCHE PON3 PON1 NME1 NAT1 NAT2 SLCO1A2 ABCC5 NT5C2 ABCB1 NUDT15 ADH1A GSTA2 UGT1A10 ITPA UGT2B28 UGT1A5 UGT1A4 UGT3A2 SLC22A8 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 BSG GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A CYP3A4 ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 GUK1 UGT2B4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi MAN1C1 MAN1A2 MGAT1 MAN1A1 MANEA RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCA NCF2 NCF4 RAC2 PIK3R4 NOXA1 NOXO1 NOX3 MAPK14 PRKCZ MAPK11 NOX1 PRKCB MAPK1 RAC1 S100A9 PIN1 S100A8 CYBB CYBA MAPK3 PIK3C3 PRKCD NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 RPS27A FGF4 CBL FGF9 UBA52 FGF20 MKNK1 SPRY2 MAPK1 FGF23 FRS2 MAPK3 BRAF PTPN11 UBB FGF16 PPP2R1A KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway MAFG RELA PGD NQO1 GSTA3 MUL1 GSTA1 SESN1 SRXN1 CHD6 CUL3 VCP CCL2 ABCF2 SOD3 G6PD GCLC GCLM TRIM21 SESN2 MAP1LC3B EGF BTRC SKP2 FBXL17 BACH1 PRKCI TXNRD1 SLC7A11 EP300 AKT2 TXN NOTCH1 PRDX1 NFKB1 CDKN1A ABCG2 CDKN2A PRKAA2 SQSTM1 ATF4 TKT ABCC3 MYC ABCC1 PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 EIF2AK3 AMER1 GSK3B IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 NPLOC4 PSMD11 ME1 PSMD14 UBXN7 PSMD13 PSMA7 BRCA1 PSMB6 PSMB7 PSMB4 DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 BCL2 PSMB1 PDGFA MAFK RPS27A AREG NFE2L2 BCL2L1 ADRM1 CSNK2A1 PALB2 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 CUL1 AKT3 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CREBBP PER3 CRY2 CRY1 BMAL1 CSNK1D KMT2A CSNK1E CLOCK NPAS2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency GSS RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle TFRC VANGL1 WDR11 SLC4A7 UACA RHOH TMEM59 JUP TUBA1B ROCK1 ARHGDIB ROCK2 CSK RALGAPA1 FAM91A1 VCP NSFL1C DBN1 VAMP3 RAB7A SLC1A5 NIPSNAP2 PAK6 ARHGDIG STOM PAK1 PAK5 LCK MTR ARHGDIA PAK2 ZAP70 LAMTOR1 PAK4 OSBPL11 DBT CAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A PACS1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLCO4A1 SLC26A2 SLC22A5 SLC17A1 SLC24A2 SLC24A3 SLCO2B1 SLC41A2 SLC5A1 SLC26A11 SLC41A1 SLC5A2 SLC30A10 SLC16A2 SLC39A6 SLCO1B1 SLC39A5 SLC26A1 SLCO1B3 SLC39A8 SLC15A1 SLC39A7 SLC14A1 CTNS CP SLC39A2 SLC15A3 SLC14A2 SLC6A5 SLC39A1 SLC15A4 SLC4A10 SLC39A3 SLC2A9 SLC30A8 SLC26A4 SLC30A3 SLC26A7 SLC30A2 SLC26A3 SLC31A1 SLC26A9 SLC30A5 SLC26A6 SLC40A1 SLC39A10 SLC25A1 SLC2A1 SLC30A1 SLC2A2 SLC6A2 SLC39A14 SLC13A1 SLC6A3 SLC8B1 SLC8A1 SLC13A2 SLC22A12 SLC8A2 SLC13A3 HEPH SLC13A4 SLCO1C1 SLC2A10 SLC47A2 SLC47A1 SLC5A12 SLC5A10 SLC25A26 SLC24A4 SLC16A7 SLC16A8 EMB SLC11A1 SLC16A3 SLC13A5 FGF21 RSC1A1 AHCYL2 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 SLC24A5 SLC22A4 SLC22A3 SLC22A6 SLC45A3 SLC10A6 SLC22A15 SLC22A16 SLC22A11 SLC20A1 SLC8A3 SLC2A6 SLC2A7 SLC2A8 PDZD11 SLC50A1 SLC4A8 SLC4A9 SLC6A20 SLC35B3 SLC43A2 LCN9 SLC1A1 SLC35B2 SLC43A1 SLC27A1 SLC1A2 SLC35B4 SLC3A1 SLC35D1 SLC1A3 SLC35D2 SLC1A4 LCN15 SLC3A2 LCN12 SLC7A11 SLC7A10 SLC35A2 SLC1A6 SLC35A3 SLC33A1 SLC1A7 SLC5A6 SLC7A1 ARL2BP SLC7A3 LCN1 SLC25A29 SLC29A4 SLC38A3 SLC27A6 SLC38A2 SLC28A2 SLC36A4 SLC29A1 SLC38A5 SLC2A13 SLC28A1 SLC38A4 SLC29A3 SLC36A1 SLC5A11 SLC6A19 SLC5A3 SLC29A2 SLC28A3 SLC38A1 SLC27A4 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC5A5 SLC32A1 SLC6A13 SLC20A2 SLC6A1 SLC6A9 SLC17A6 SLCO1A2 SLC1A5 ARL2 SLC67A1 SLCO4C1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 SLC22A7 SLC12A2 RUNX1 SLC12A4 SLC6A7 SLC12A5 SLC12A7 SLC6A11 SLC25A18 SLC25A11 SLC6A4 APOD SLC17A7 SLC25A22 SLC2A3 CALM1 SLC35C1 SLC4A7 SLC25A10 SLC24A1 SLC17A5 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 AVP SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC2A4 SLC35A1 SLC22A8 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 BSG SLC5A9 SLC12A6 SLC60A2 SLC39A4 SLC34A3 SLC5A4 SLC34A2 SLC2A14 SLC34A1 SLC2A11 SLC11A2 SLC2A12 SLC5A7 SLCO2A1 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 CDK2 MLH1 FIGNL1 TEX15 MSH4 MSH5 MND1 FIRRM BLM MRE11 BRCA1 BRCA2 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 H2AC19 H2BC26 H2AC14 SPO11 H2BC12L H2BC21 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 H2BC11 ATM H3C15 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation JUN IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 HRAS VAV3 VAV1 VAV2 SOS1 V2-11 V3-4 NRAS V3-3 V2-17 IGHE V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 MAPK8 MAPK3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN MAP2K4 MAPK9 SYK PAK1 MAP2K7 MAP3K1 MAPK10 FOS PAK2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 HES5 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 TACC3 MAMLD1 PSEN1 RBPJ SMAD3 ACTA2 SNW1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 FLT4 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A HEY1 KAT2B KAT2A EP300 HEY2 JAG1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 MAML3 NOTCH2 NOTCH1 CUL1 NOTCH4 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EED UXT PCGF6 RRM2 EPC1 CDC7 E2F1 RBBP4 EZH2 BRCA1 RYBP RBBP7 TFDP1 TFDP2 CHEK1 RBBP8 YAF2 EHMT2 EHMT1 MAX BMI1 CBX3 RING1 L3MBTL2 RNF2 E2F6 SUZ12 RAD51 PHC1 CBX5 MGA PCGF2 PHC3 APAF1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 GLRX5 FDX1 FXN SLC25A28 FDX2 SLC25A37 LYRM4 FDXR HSCB RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport CYCS MT-ND6 COX5B COX5A MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 COX6C TMEM126A UQCRC2 TMEM126B TRAP1 SURF1 COX6A1 COX6A2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 COX6B2 NDUFAF2 SFXN4 COX6B1 NDUFAF3 NDUFAF1 HIGD1C HCCS TMEM186 RAB5IF OXA1L ACAD9 COQ10B COQ10A TMEM177 DMAC1 DMAC2 UQCR11 UQCR10 PET117 TIMMDC1 PET100 MDH1 MDH2 NUBPL LETM1 LYRM2 LYRM4 LYRM7 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 NDUFAB1 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 COX18 HIGD1A UQCRH COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 UQCRFS1 COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 MT-CO1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 BCS1L COXFA4 NDUFA6 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 COX19 TTC19 COX17 UQCRHL SCO2 MT-CO2 MT-CO3 CYC1 NDUFS3 GOT2 HSCB ECSIT HSPA9 TIMM21 SLC25A12 FXN SLC25A13 NDUFB8 COX7B COX7C COX8A COX8C FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm TBX6 BMP4 LEF1 MAMLD1 CTNNB1 MESP2 DLL3 HES7 MSGN1 RBPJ RIPPLY2 SNW1 EPHA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 NOG PSMD11 PSMD14 PSMD13 WNT3A PSMA7 PSMB6 FGFR1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP MAML2 PSMB1 MAML1 KAT2B KAT2A LFNG EP300 ADRM1 TBXT PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 MAML3 NOTCH1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 SEL1L MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 CP MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 RNF185 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 DERL1 MRPL45 DERL2 MRPS6 RNF5 MRPL46 MRPS5 OS9 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 ARF4 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 EXOC8 EXOC7 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 EXOC4 MRPL12 EXOC3 MRPL57 EXOC6 MRPL13 EXOC5 MRPL54 EXOC2 MRPL10 EXOC1 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 GBF1 MRPL21 MRPL22 KGD4 RAB11A MRPL30 MTRES1 MTRFR NDUFAB1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN PIAS3 DDB1 UBE2V2 COPS7B XPC COPS7A CUL4A COPS3 COPS6 COPS5 UBE2N COPS8 BDH1 OXCT1 HMGCS2 ACAT1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 CAPZA3 CAPZA2 ACTR10 SQSTM1 TFAP2B TFAP2C TWNK UBE2I SUMO1 SSBP1 EIF1AX EIF4H UBE2D2 EIF3M UBE2D3 EIF3K HIF3A EIF3L EIF3I ELOB EIF3J ELOC EIF3G RBX1 EIF3H EIF3E EPAS1 EIF3F CUL2 EIF3C HIF1A EIF3D VHL EIF3A EIF3B GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 EIF5A FBXL5 DHPS WRAP53 FN3KRP TUBA8 GNGT1 EIF5A2 TUBA1C FN3K ICMT TUBA1B GNGT2 DOHH TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 KLK13 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 NUP37 CDC20 MT-ND4L PARS2 MRTFA EARS2 LARS2 PPA2 DYNC1LI1 PPA1 TARS2 DYNC1LI2 TARS1 AARS1 AARS2 HARS1 HARS2 CDCA8 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 TCF25 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 DYNLL1 CARS2 VARS2 RANGAP1 ANKZF1 KLHDC10 DYNLL2 TSFM EIF5B RHOA MARS2 DARS2 INCENP EEF1G BIRC5 SARS2 NEMF EEF1D MTRF1L EEF1A1P5 MTIF2 PRMT3 MTIF3 DYNC1I2 IARS2 WARS1 WARS2 AURKB DYNC1I1 DYNC1H1 TFG GOLGB1 GLUD1 NFKB2 ANK1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ACE2 LAMB2 FN1 LAMB1 LAMC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 RPS20 LRR1 CCNF FAU RPS21 UBE2L6 RPS24 B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B ASCC2 ASCC3 CDC34 SFTPA2 PSME1 FSHB INHBB UBE2J2 INHBA INHA INHBC INHBE SEC31A SIAH1 FBXL8 EIF4EBP1 CALR FBXL4 EIF4E EIF4B LRRC41 GAN RRAGA KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 CUL7 CUL5 UBA6 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H YKT6 KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 SEC61A2 SEC61A1 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 GALNT1 CALCA ARFGAP3 ARFGAP2 IAPP MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 TPST2 SEC16A KTN1 TPST1 TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RPL4 RPL5 RPL30 RAD52 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A MATN3 RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 CHD3 RPL23 BMI1 RPL22 RPL13A SUMO3 RPL9P9 SUMO2 RING1 RPL37A PIAS1 RPL24 HDAC4 RPL27 HDAC2 RPL26 L3MBTL2 RPL29 SATB1 RPL28 SATB2 RPL10 RNF2 RPL12 ZBED1 RPL11 RPL36A SUZ12 CBX8 RPL14 PHC2 RPL13 PHC1 RPL15 CBX5 RPL18 CBX4 RPL17 PCGF2 RPL19 CBX2 RPL39L PHC3 RPL41 AMER1 RPL35A RPL23A RPL3L AXIN1 RPL27A RPL22L1 APC ABCE1 RPL26L1 CDC73 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 RWDD3 UBA2 SAE1 CREBBP AREG NFE2L2 SAA1 TGFA EIF2AK2 MGAT3 APEH HEMK2 ETF1 GSPT2 GSPT1 APOB MME CES1 USO1 TUBB8 RAB2A TUBB8B EIF2B5 EIF2B4 EIF2B3 EIF2B2 RAB1A EIF2B1 RAB1B HGS RAB5A TOP2A GORASP1 STARD7 FDX1 OMA1 OPA1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 FUT8 MITF GANAB MAN2A1 MGAT5 MGAT1 MGAT2 OST4 EDEM2 MOGS ARF3 ACHE DDOST MGAT4C HTRA2 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 LONP1 TRRAP CCP110 BCHE KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 AGT USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PIAS4 VDAC1 CFTR GATA3 BRCC3 SNX3 RHOT1 RCE1 ZRANB1 SIAH2 INO80 STAM TADA2B CYLD H2AC25 H2AC21 BAP1 WDR48 OTUD7A OTUD7B RAB4A BABAM1 IFIH1 BABAM2 UCHL1 TRIM4 UIMC1 UFD1 IKBKG TOMM70 RIPK2 ACTL6A JOSD2 UCHL3 JOSD1 ALAS1 UCHL5 DDB2 KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 USP17L21 USP17L20 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 SFTPC USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 ECI1 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 CLSPN SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 STAR USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 USP25 USP26 USP20 USP21 RAB32 USP22 RAB35 TAF10 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 HADH RAB39B RAB8B RAB33A RAB7B RAB21 CHML RAB11B RAB12 RAB13 ARG2 ALPI HNRNPK PIGS PIGU PGAP1 PIGT GPAA1 PIGK OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 CDH2 METTL21A KIN MYO5A METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT MYRIP EEF1AKMT2 EEF1AKMT1 DDX5 FFAR4 GRP U2AF2 GALNT11 GALNT14 GCG GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNTL6 P2RY2 ADRA2C COL7A1 ADRA2A MDC1 MT-CO1 B4GALT1 DTL MT-CO2 MT-CO3 GATA4 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 FOXL2 HIC1 SP3 ALDH2 PPARG PPARA LY6E MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 BGLAP SPP1 SUCLG2 UQCRC2 OGDH MT-ATP6 RORA FH DLST ATP5PF ATP5PD MDH2 ATP5F1C MT-ATP8 ATP5PO NDUFA13 SOCS3 NDUFV3 ATP5MG NDUFV1 IDH2 UQCRQ MT-CYB ETFB ME2 IDH3A FBXO32 SFTPB SFTA3 SFTPA1 NDUFS1 NDUFB6 COX4I1 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 RABGGTB ADGRF5 RABGGTA NDUFA2 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 EEF2 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NR5A1 PCNA COX5B COX5A RELA NPM1 NR3C1 NPPA KLK3 SP100 KLK2 RAB9A RAB9B KIF5B KIF5A VDR IL6 PCSK2 ERO1B CPA3 CDX2 LEP ENPEP CPB1 SENP5 CLTRN SENP2 NOP58 TRIAP1 ACE CPE REN CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 IGFBP2 SHISA5 PDIA6 PAPPA MXRA8 SPARCL1 IGFALS AURKA SCG2 KLK1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A ZNF131 FUCA2 UHRF2 DDX17 HRC CASP8AP2 MELTF MBD1 SERPINA10 SAFB MIA3 MSLN TOPORS PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 B4GALNT2 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 TOP2B TOP1 SERPIND1 GOLM1 POFUT2 GZMH NUCB1 NOTUM POFUT4 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 PRELID1 LYPD8 LYPD6B PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CPB2 LRRC49 PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 CHM TTLL1 TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H ING2 SPRN SPACA4 NICN1 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 RAB22A CD59 CD52 CD55 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 RAB40A ZNF350 RAB40B RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 RAB29 RAB15 RAB19 RAB17 TTLL10 NFU1 TTLL13 MEN1 TTLL11 TTLL12 IGFBP1 UMOD LIAS OTOA RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FUCA1 WDR5 RAB3D RAB44 RAB31 RAB37 RAB5B RAB5C HDAC7 RAB6A TRAPPC1 RBBP5 RAB4B RBBP7 FCGR3B KLF4 PML MSRA PCMT1 MSRB2 MSRB3 MSRB1 TTR RAB24 RAB10 TSPAN14 RAB18 ANPEP TXN COMMD9 PARP1 BST1 VNN1 CTSZ CTSH CTSC COMMD3 KCTD6 NR4A2 SRP14 THRB CGB8 COPB1 NR2C1 THBS1 HSPD1 ADA2 POMC ATP6AP2 FGA PLAUR FGG CAND1 F7 F9 PROC F10 GGCX PROS1 PROZ F2 GAS6 DBT DLD PCSK9 APOA2 APOA1 APOA4 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB BTRC ADAMTS13 MTA1 HSD17B10 EPRS1 TRMT112 SOCS2 SOCS6 IKBKE CETN2 ACTR1A CSNK1D DCTN2 DCTN3 JMJD6 RIOX2 ANO8 RNF168 ANKRD28 ASPH PPP6C PPP6R3 TP53BP1 COP1 SMC1A SMC3 STAG1 STAG2 RAD21 TDG DCAF13 PRL CALB1 NAT8B BACE1 APCS TSPAN33 GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI ITM2B CSF2RB CSF2RA NCOA2 PNPLA2 TTF1 CTBP1 DNMT1 DNMT3B DNMT3A SLC30A8 SLC30A5 STS ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD SFTPD TUFM UBE2L3 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MARS1 DARS1 SARS1 EEF1E1 GSN KARS1 IARS1 UBE2T OTULIN ALDH1B1 APH1A PSENEN NCSTN APH1B ADAM10 FBXL18 FBXL7 SDC2 TMED2 GPC3 ADORA2A UCN MBOAT4 PLA2G7 CRHR2 GH1 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 TSHB DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF1 NPLOC4 DDA1 RPLP0 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CISH CUL9 DPP3 HSPA9 UBD NAE1 SOCS5 WDTC1 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B CAPZA1 NEURL2 ERCC8 PSME2 GOSR2 SSR1 ARFGAP1 SRPRA SRPRB PREB KDELR3 PCCB PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 RWDD1 SEC11A JMJD4 KDM8 SEC11C JMJD7 RIOX1 OGFOD1 DRG1 DRG2 RCCD1 ZC3H15 ADORA2B SHMT2 STX5 CMA1 IDE CAPZB GATA6 CTSD TFAM SCFD1 SPTBN1 PARK7 MUC13 INS FGF23 ABCA3 GRIA1 CKAP4 SENP1 CALM1 NDUFS3 UBE2C UBE2E1 UBE2D1 PDHB UBE2S CDK1 DLAT BLM PDK1 BRCA1 PDHA1 WRN BARD1 FBXW11 RPA1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 RAB41 KIF5C KNG1 COG8 COG7 COG6 COG5 IGF2 COG4 RAB27B COG3 CTSG IGF1 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG LTF MAN1A2 F5 TMED3 F8 MMRN1 MAN1A1 TMED7 PLG TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B ARF5 NAPA NAPB GOSR1 NAPG GOLGA2 LYZ BPIFB2 MAN1C1 SEMG1 SPG7 GALNT2 AFG3L2 ARCN1 SMDT1 YME1L1 PMPCA MICU2 COPG2 COPG1 LTBP1 TCF7L2 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A CHCHD2 CTNNB1 EIF2S2 EIF2S1 EIF2S3 ECH1 SPTB ACOT2 STX1A MYC LDHD ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 SPTBN5 PSMD2 PSMD3 SPTBN2 PSMD1 NUP214 CS PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ACO2 PABPC1 UBA52 PSMD12 SEC61G PSMD11 TIMM17A PSMD14 SEC61B PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 TIMM22 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 PSMC5 PSMC6 TIMM9 PSMC3 PSMC4 PSMC1 PSMC2 TIMM10 EIF4G1 ATP5F1A ATP5F1B PEX10 PEX12 SRD5A3 C3 PEX13 PEX14 FURIN IL33 RNF20 CCT2 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC CCT7 B2M HLA-A VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT CCNE2 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 H2BC11 RARA H3C15 RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 HDAC3 KDM1B GNAT3 NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 FBXL21P ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 SLC34A2 MRPS17 SLC34A1 MRPS15 MRPS16 MRPS14 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR BTRC JAK2 SKP1 RBX1 CUL1 PTPN11 GH1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 ALOX15B PTGS2 ALOX15 GPX2 GPX1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix MMP15 COL18A1 MMP17 MMP19 TMPRSS6 NID1 FURIN CAPN8 SPP1 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 CTSG HTRA1 SCUBE3 PRSS2 SCUBE1 BMP1 KLK2 MMP25 A2M TIMP2 ADAM17 SPOCK3 CAPN13 TIMP1 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 DCN TLL1 BCAN PLG LAMA5 LAMB3 CMA1 ELANE LAMA3 ADAM8 LAMB1 LAMC2 LAMC1 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST MMP1 MMP2 CTSD MMP3 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 NCSTN COL23A1 HSPG2 ADAM10 PSEN1 ACAN COL9A1 CD44 COL9A3 COL9A2 CDH1 CTSS ADAMTS4 ADAMTS5 ADAMTS1 ADAMTS8 ADAMTS9 KLKB1 ADAMTS16 ADAMTS18 MMP8 MMP9 PRSS1 PHYKPL CTRB2 CTRB1 OPTC KLK7 CTSB BSG CTSV MMP20 MMP24 CTSL TPSAB1 MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 CASP3 MMP16 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT5A STAT5B STAT3 IL22 JAK3 STAT4 JAK2 IL20RA IL20RB IL22RA2 JAK1 STAT1 IL22RA1 IL10RB PTPN11 TYK2 IFNLR1 IL20 STAT2 IL26 IL24 IL19 IFNL2 IFNL1 IFNL3 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers JUN ADCY9 NTRK3 NTF3 ADCY4 ADCY3 PDGFB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 IRAK1 ITPR2 ITPR3 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PRKAR1B PRKAR2B PDGFRA PRKAR1A RAC1 PRKAR2A PRKX KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PRKCD PRKCA PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 AHCYL1 PSMC4 PDE1C PSMC1 CSNK2B CAMKK1 PSMC2 CAMKK2 GRK2 KPNA2 PRKCG TP53 PRKCE NBEA CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 PLCG1 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 CAMK2B ESR2 CAMK2D HDAC2 SRC NR4A1 CAMK2A NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 CALM1 GSK3B CAMK2G IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK CAMK4 FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 TGIF2 EED POMT2 POMT1 PRKCI RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures MUS81 FIRRM BLM SLX4 RTEL1 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 PGM1 GALM DHDDS DPM1 NUS1 DPM2 DPM3 GALK1 MPI GALE PMM2 GFPT1 DOLK GNE GALT POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events PRKCA GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 ADRA2C RGS4 ADRA2B RGSL1 ADRA2A GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCB GNAI3 RGS20 PRKCH RGS17 GNAI1 RGS19 PRKCG PRKCQ GNAI2 PRKCE RGS16 GNG10 GNG12 PRKCD GNG11 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G2D PLA2G2E PLA2G3 PLA2G5 PLA2R1 PLA2G10 LPGAT1 PLA2G4F PLA2G12A PLA2G4D PLA2G4B PLA2G2A PLA2G1B LPCAT4 CRLS1 PLA2G2F LPCAT1 PLA2G4A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse PLXNB1 ERBB2 RHOC SEMA4D RHOA LIMK2 RHOB LIMK1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MYH10 MYL9 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 PTEN EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 AKT2 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 TRIB3 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A THEM4 PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PHLPP2 PIP5K1C PHLPP1 CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN AKT3 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism ALDOB GLYCTK SORD KHK ALDH1A1 TKFC AKR1B1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria ASL KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF28P KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIF5C KIF21A KIF21B KLC1 KIFAP3 KLC4 KIF2A KLC3 KLC2 KIF2C KIF2B KIF16B KIF3A KIF20B KIF3B KIF3C KIF5B KIF5A KIF18B KIF26A KIF4B KIF26B KIF4A KIF12 CENPE KIF11 KIF23 RACGAP1 KIF15 KIF19 KIF13B KIF1C KIF1B KIF18A KIF20A KIF1A KIF25 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes CREBBP PRDX1 ATF4 MAFK SLC7A11 GCLC NFE2L2 EP300 GCLM NQO1 GSTA3 GSTA1 SRXN1 CHD6 HMOX1 TXN SOD3 BACH1 TXNRD1 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease SOS1 CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 NRAS TRIM24 PLCG1 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 HRAS ZMYM2 GAB1 FGFR1OP2 FRS2 GAB2 PIK3CA SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC PHOSPHO1 CHPT1 ABHD3 PCYT1B PCYT1A CHAT CHKB CHKA STARD10 MFSD2A ACHE LPCAT1 PCTP LPIN1 LPIN2 LPIN3 CSNK2A1 CSNK2A2 CEPT1 BCHE CSNK2B STARD7 PEMT SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PLCG1 FGF20 FGF23 FGF22 FGF16 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency CPS1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CHTOP ALYREF DDX39B SRRM1 DHX38 NXF2B NXT1 UPF3B MAGOHB RNPS1 NUP205 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency BTD LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs RHOC PPP1R12A RHOA LIMK2 RHOB PAK1 LIMK1 ROCK1 MYL12B ROCK2 MYL6 MYH9 CFL1 MYH14 MYH11 MYH10 MYL9 PPP1R12B PPP1CB DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) UBC TICAM2 TICAM1 RPS27A TBK1 IRF3 TRAF3 OPTN LY96 UBA52 CD14 IKBKE IRF7 TANK PTPN11 UBB TLR4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription HES1 HDAC5 CCNC HDAC1 UBA52 HES5 TLE4 HDAC3 HDAC8 TLE2 HDAC9 TLE1 HDAC6 HDAC7 HEYL MAMLD1 TBL1X UBB RBPJ CREBBP UBC CDK8 MAML2 NCOR2 MAML1 RPS27A HEY1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 EP300 SNW1 HDAC11 MYC HEY2 HDAC4 HDAC2 SKP1 RBX1 MAML3 NBEA HIF1A NOTCH1 CUL1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines NSD2 KMT5C SUV39H1 MECOM H4C9 RELA EED SMYD3 NFKB1 ATF7IP SETD1B SETD1A AEBP2 RBBP4 NFKB2 EZH2 RBBP5 PRDM16 RBBP7 KMT2D PRDM9 EHMT2 EHMT1 ASH2L KMT2C KMT2B SETDB2 SUV39H2 SETD2 SETD3 SETD6 SETD7 H3C8 ASH1L DOT1L SMYD2 NSD3 SUZ12 NSD1 DPY30 SETDB1 WDR5 KMT2A KMT5A H3C15 KMT5B METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway GOT1 MRI1 MTAP APIP ENOPH1 ADI1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes JUN PMS2 MLH1 CDK12 CDK13 FANCI MDC1 ATF2 FANCC FANCD2 CCNT2 ELOB ELOC CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L MSH2 GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 BRCA1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 CHEK1 NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 DDB2 CDK9 TCEA1 RAD51D FOS TP53 ATM ATR FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation SERPINA5 CD177 THBD F13B PRTN3 SERPINC1 F13A1 PROC F10 SERPIND1 F5 FGB PROS1 F8 PF4V1 FGA F2 SERPINE2 FGG PF4 F2R PROCR RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB8B RAB43 RAB14 RAB41 RAB33A RAB7B RAB21 RAB27B CHML RAB11B RAB12 RAB30 RAB13 RAB36 CHM RABGGTB RABGGTA RAB9A RAB6B RAB9B RAB39A RAB22A RAB3D RAB40A RAB40B RAB44 RAB40C RAB3A RAB33B RAB31 RAB2A RAB37 RAB5B RAB5C RAB3B RAB3C RAB42 RAB11A RAB6A RAB1A RAB2B RAB1B RAB4A RAB4B RAB34 RAB5A PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB7A RAB29 RAB32 RAB15 RAB35 RAB19 RAB17 RAB27A RAB38 RAB24 RAB8A RAB10 RAB18 RAB39B 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4F3 CYP4A22 CYP4B1 CYP2U1 CYP2S1 CYP4F2 CYP2W1 CYP2D6 CYP4A11 CYP3A43 CYP4F22 CYP4F11 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle ARHGEF9 ARHGAP26 OBSCN MPP7 VANGL1 ARHGAP32 ARHGEF7 ARL13B RHOQ TRIP10 CDC42 CPNE8 STEAP3 GJA1 FNBP1 SCRIB GFOD1 LAMTOR1 IQGAP1 TFRC IQGAP3 SNAP23 CFTR ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 GOPC SYDE1 ARHGAP33 OPHN1 GIT1 WASL PLEKHG3 DEPDC1B CDC42EP1 VAMP3 RAB7A CDC42EP4 CDC42EP3 CDC42EP2 ITSN1 ARHGAP17 SLC1A5 ARHGAP21 PREX1 STOM PAK1 CDC42BPB SRGAP2 CDC42BPA PAK2 DLC1 PAK4 DIAPH3 GIT2 CAV1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol TRIT1 ADAT2 TRMT6 TYW5 TRMT61A TYW3 TRMT5 TYW2 TYW1 LCMT2 ALKBH8 THG1L TRMT44 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B EPRS1 TRMT13 TRMT11 QNG1 TP53RK WDR4 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 URM1 LAGE3 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress CXCL8 DCP2 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EXOSC4 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP DIS3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome HBEGF PXN AREG EGF PIK3R1 EGFR SRC CSK TGFA GAB1 EREG PIK3CA BTC PTPN11 EPGN PAG1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 RBX1 NOTCH1 CUL1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A3 SLC22A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints PLK3 CDKN1A CDKN2A CDC25A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 CHEK1 PSMB5 CSNK1E CCNE1 NEK11 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 TP53 CCNA1 ATM CUL1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB ACADL HADHA SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAP2K1 MAP2K2 MAPK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN DOCK3 RAC1 GRIN2B NTRK2 BDNF SRC MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN PRP4K ZCRB1 WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina PRKCB PRKCA EMD LMNB1 LPIN1 CCNB1 LPIN2 LPIN3 CNEP1R1 CDK1 LEMD3 LEMD2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response OAS1 OAS3 ABCE1 RIGI RNASEL FLNA OAS2 PDE12 OASL PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane TMEM258 DAD1 OSTC STT3A STT3B RPN2 TUSC3 PDCD1LG2 B3GNT3 RPN1 PDCD1 MAGT1 MIB2 OST4 JAK1 CD274 DDOST RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 CDC42 KLC4 RAC1 KLC3 KLC2 KTN1 KIF5B RHOG KIF5A RHOA KLC1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins LY6E CD109 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 BST1 LYPD6B PIGO VNN1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH ALPI LY6K GPIHBP1 LY6D LY6H SPRN SPACA4 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 CD52 PRND CNTN5 CEACAM5 ALPL CNTN3 CNTN4 ALPG TEX101 GPLD1 GP2 PRSS21 PRSS41 DPM1 DPM2 DPM3 TECTA TECTB VNN2 PIGS PIGU PGAP1 PIGT GPAA1 PLET1 CPM PLAUR PIGK PSCA MELTF RTN4RL2 MSLN FCGR3B RTN4RL1 OTOA RAET1G RAET1L IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM FOLR2 ULBP2 OPCML NEGR1 XPNPEP2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 MYO6 AP2M1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation CYB5B NOSTRIN HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NOSIP WASL DNM2 NMT2 AKT1 ZDHHC21 CALM1 CAV1 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB PDHX FH SUCLA2 MPC1 SUCLG2 HEL-S-133P SUCLG1 GPT DHTKD1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN3 COMP MATN1 COL9A1 COL9A3 COL9A2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 TGFB1 STAT3 ENPP2 RHO LPA CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC4 TUBA2 PSMC1 STUB1 TUBA8 UBE2L6 PARK2 UBE2L3 HEL-S-89n TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD5 PSMD2 RNF19A TUBB1 PSMD3 PSMD1 GPR37 FBXW7 HEL-S-103 TUBB HEL-S-72p CASK SEPT5 TUBA4B TUBA4A TUBB2A CCNE1 PSMD10 PSMD12 PSMD11 HEL-S-91n TUBAL3 PSMD13 HSPA14 UBE2J2 UBE2J1 TUBA3E SNCA HSPA4 SIAH2 SIAH1 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B TUBB4A PSMC6 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 INSR PDX1 PDGFA BRAF IGF1 FOXM1 TGFBR1 FOXO1 IGF1R INS RAB43 RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways RGS16 CAMK2A ADCY3 ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G CORIN GUCA2B GUCA2A RGS10 ACKR3 RGS11 RAMP1 ACKR5 ACTA2 ATF1 ATF2 MYLK2 HEL2 OXTR CRCP GABPB1 ETS2 SLC8A1 RXFP2 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 IGFBP1 PRKCH IGFBP5 PRKCB IGFBP4 PRKCE IGFBP2 PRKCA DGKZ MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA LPAR1 HEL-S-14 ITPR2 PRKCZ CRHR1 CNN2 GRK5 GRK4 CALD1 PLCG2 SFN PLCG1 IGFBP6 JUN GNG12 GNG11 NFKB1 GNG13 PKIB IL6 SP1 PKIA GNB2 MAFF GNB1 GNAS GNB4 GNB3 RLN1 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADM OXT ARRB2 RYR3 GNGT1 YWHAQ PS1TP5BP1 PDE4B HEL-S-1 YWHAG GABPA HEL-S-21 PDE4D FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 RGS17 CAMK2D RAMP2 RAMP3 RGS14 ATF6B 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2I2 HEL-S-71 NRROS TFRC CEP19 HFE SLC40A1 PIGX H2BC21 UBXN7 SMCO1 DYNC2H1 NCBP1 DYNLT1 NCBP2 DYNLT3 ADAM10 SLC51A SLC51B SIRT1 DYNLL2 FNDC8 RNF168 PIGM MFI2 DYNLT2B PXN MYCBP2 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 ZDHHC19 BRINP1 STAT5B TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP WDR53 ZNF76 TF DYNLRB2 NF2 DNCL1 HAMP TGFB1 JUN FBXW7 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 E2F3 MYC PIK3R1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 PARP1 NAMPT TFAM HIF1A PPARG FOXO3A ROS1 SIRT1 SIRT3 FOXO1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 MAPK1 MAPK3 PIK3R1 SLBP CBL FGF2 ERI1 NSD2 TMEM129 CLTCL1 NELFB UBE2J2 FAM53A NELFCD NELFA POLN H3F3B FRS2 CKAP5 LETM1 NICOL1 TACC3 GRB2 NAT8L SOS1 FGFR3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2C MEF2B CCND2 NKX2-5 KLF4 MEF2D CAMK2D MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers ADM CRP PBR GRN CCL23 CCL11 BDNF TREM2 DBI S100B TREM1 CX3CL1 IL6 GFAP CCL5 IL1B OLR1 TNF CHI3L1 NEFL CCL2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 APOB LDLR PLTP USF1 GPIHBP1 LPL GHR LIPC EPHX2 APOA2 PCSK9 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies IL6 C1QB C1QA CD40 IL25 CD80 C4B_2 C2 C4A CD19 IL12B TNLG7A IL12A IL6R HEL-S-62p CD40LG IFNG IL23A IL17F IL17D IL17C MS4A1 IL17B CD22 IL17A C1QC EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1H1 DYNC2H1 DCTN1 TRAK1 ATAT1 DYNC1LI2 RHOT1 SYPL1 CASP3 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A SNCA DYNC2I2 CASP8 RAB3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome VCP IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 E2F4 CIMAP3 SNAPIN PTCH1 CEP19 RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 DNM3 TFDP2 SMO RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 STX5A IFT25 RABL2B SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 SMAD4 HEL113 TNC RUNX2 CDH6 CDH2 ID1 SNAI1 SNAI2 CDH16 AKT3 MAPK1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR2 TPH2 TPH1 KDM3A GRIN1 CHRM1 KDM1A KDM1B CYP27B1 CALB1 RXRA KDM6B NR1i1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 HEL-75 CYP27A1 GCLC KCNQ2 BCL2 SLC8A1 KCNQ3 PVALB NFE2L2 CACNA1C GRIN2B VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway HADHB CYP2C9 CYP2A6 HSD17B10 CYP2B6 HDAC1 EHHADH IVD ABAT ACADSB FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis TFRC SLC40A1 CYBB GCLC STEAP3 CISD1 SAT2 SLC7A11 BACH1 MAP1LC3A MAP1LC3C AIFM2 FTH1 SLC39A8 HEL-S-64p HEL-S-102 SLC38A1 GPX4 ACSL1 SLC11A2 ACSL6 FACL4 ACSL5 ACSL3 TF SLC39A14 POR DKFZp762B153 CHMP6 CHMP5 FTL IREB2 ALOX15 SLC3A2 HMGCR DPP4 FTMT CBS PCBP1 PHKG2 HMOX1 FDFT1 ATG5 PRNP AKR1C1 AKR1C2 CP COQ2 LPCAT3 VDAC3 CTH GCLM NOX4 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX1A SLC25A4 NAPA SNAP25 SLC22A3 STXBP1 CLTC DNM3 CACNA1B CLTA SLC1A3 CACNA1A AP2A1 CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 AP2S1 SLC17A6 SLC17A7 SLC17A8 CLTCL1 STX2 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B UNC13C UNC13A SYT1 SLC32A1 SLC38A1 SYP SYN2 SYN1 STX1B STX3A VAMP2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IFITM3 ANKRD13C CREBBP HDAC2 CADM1 IRS1 TET2 EP300 PIP4K2A HDAC1 NOL9 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG GATA3 GATA2 KLF15 KLF2 PPARG DDIT3 CEBPA CEBPB EGR2 KLF5 CEBPD ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins DKFZp762B153 RB1CC1 RAB7A ATG5 PRKAA2 CALCOCO2 HEL-S-30 PPP1R9A RPTOR LARP1 MTOR ULK1 DEPTOR LAMP2 MLST8 VPS11 APOB VPS39 EIF4B VPS16 ATG3 VPS18 GABARAPL2 VPS33A RPS6 ATG9A ATG12 VAMP8 TMEM59 RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 NBR1 LAMTOR1 SQSTM1 ATG2B OPTN INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 GRN SIRT1 RHEB MYCBP2 RB1 SMEK1 ZMYND8 NAB1 DHTKD1 MAP3K7CL AHR STK11 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 CSNK1D TSC1 ARAF PPP4R3B BAX MYT1 RHO CCNB1IP1 CDC25B PIAS1 MSH6 EDAR MSH2 LGALS13 BLM MAX RASGRP3 RAP1A RRAS NUP85 TPR BARD1 CASP8 UBE2F SMAD1 PLK3 APOBEC3G GADD45A PIK3R2 XRCC3 PLK1 ERAL1 SMAD6 SMARCA4 FADD FOSL2 FOSL1 FER CDK7 NOXA1 NF1 MDM2 ATM ZNF655 MAP3K13 CERK BMPR1A ATR PIGR GSK3A BMPR2 GDI1 TRADD PTEN BRCA1 BRCA2 RASGEF1A RAC1 JAK1 ANXA1 DCAKD TGFBR2 ITPKC USP15 RALA USP16 SELENOK TFPI SMAD2 EGFR SMAD4 AURKA PAK1 BAK1 STAT1 USP21 MRE11A BRAF PML HIPK2 VEGFA TGFBR1 MAP3K7IP1 FOXO1 WEE1 RAD50 RAD51 FILIP1 CTNNB1 FAU CDK4 MYC IRS1 CDK2 MAPK1 KRAS ATF1 BCL2 HDAC1 BACH1 CASP9 CASP3 CHUK HMGCR JUN NFKB1 SP1 PKIA BAD MTOR CDC42 CREB1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP9 CASP3 APAF1 BAX TNFRSF1A NEF3 TOMM40 SLC1A2 DERL1 HEL-S-2 TNF NEFH NEFL MAP2K6 MAP3K5 GPX1 BAD HEL-S-44 MAPK14 MAP2K2 CCS SMIM40 RAB5A BCL2L1 BCL2 PPP3CA CASP12 RAC1 PPP3CC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism RELA INSR CRP CBS INS NFKB1 IL6 CCL5 TNF CCL2 CTH HEL-S-44 SCARB1 APOB SERPINA3 LDLR MTRR SAA4 HBB APOE MTR PLAT PLG HEL-S-51e MPO MCEE ABCA1 FGA CUBN CBLIF HBA2 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG TCN2 TCN1 IL1B ALB SAA1 SAA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 HEL-S-30 HEL-75 EHHADH PDHX FH HEL-S-133P SUCLG1 HEL-S-64p PNMT HEL-S-32 HEL-S-61p DBH FTCD GLS TDO2 HEL-S-53e PDK4 ACADM PIG59 HEL-S-4 ARG2 RARS1 ARG1 GPT2 MCCC1 CAD SDHA HEL-S-26 CBS ACLY LARS2 SMS BCAT1 ALDH7A1 DLD DDC ADH1C PPM1L MAOA HDC ADH7 CTH ADH5 GCLM SRM HMGCL TPO PCK1 ACSS1 PDHA1 MDH2 GOT2 ASNS ASS1 CS GLUD1 G6PC2 HAL PC TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 IARS OTC FARSB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 TDO2 IDO1 FOXO1 KLF5 CDKN1A IFNB1 IFNG AADAT HEL-S-90n HAAO TNF IL1R2 EIF2AK1 AHR EIF2AK4 KMO KYNU AFMID IDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling ITGB1 HEL-S-130P PRL HEL-S-69p PAK1 RPS6KA2 SIRPA RELA STAT1 NEK3 CISH GAB2 PRLR VAV1 VAV2 ZAP70 PPIB SRC SHC1 AGAP2 SOCS2 MYC SOCS3 SOCS1 IRS1 ERBB2 EIF4EBP1 MAPK1 FLNA FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 NFKBIB RAF1 RPS6 RPS6KB1 PXN STAT5B GSK3B MAPK9 MAPK8 CASP3 STAT3 JUN PIK3CA NFKB1 MTOR PIK3R2 PIK3R1 CBL YWHAG FOS YWHAZ RAC1 JAK1 HRAS GRB2 SOS1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap ETHE1 MAT1A SQOR SUOX CDO1 MTR HEL-S-64p CTH HEL-S-61p CBS GCLC COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system CRP CSNK1A1 FCN1 FCN2 CLEC4M CD40 ITGB3 PLG PROS1 ITGA2B ICAM2 F13A1 C2 C4BPA C4A FGA LAMC1 CD19 C8A FCGR3A IBSP RPS19 C1QBP PRKCA HEL-S-62p HEL-S-78p C3AR1 VSIG4 MBL2 CR2 CR1 ALB CD93 ITGA2 HEL-S-92n PLAUR DCN FCER2 SERPING1 MASP2 MASP1 CD46 CFD LAMA5 FKBP2 SELPLG SFTPA2 CFH C5AR2 CFI C5AR1 WAS FPR1 GNAI3 TXN HEL-S-99n CFP THBS1 CPN1 VTN PRNP GNA15 C6 C7 C9 SPP1 CD59 CD55 ELANE F10 F11 LAMB1 SELE SELP SELL CFHR2 ADM CFHR4 PTX3 ARRB2 SFTPA1 KLKB1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC34A3 ATP6V1G1 SLC6A19 ATP6V0B ABCC2 SLC6A18 SLC36A2 ATP6V0E1 SLC34A1 SLC16A10 SLC3A2 ATP1B1 SLC9A3 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ABCG2 ATP6V1B1 SLC47A2 ATP6V1A SLC22A6 ABCB1 SLC47A1 SLC22A2 SLC1A1 SLC2A2 SLC3A1 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 SLC5A5 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1D ATP6V1C1 ATP6V1F SLC22A11 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACTA2 COL1A1 RAF1 SMAD4 TGFB1 CTGF TGFBR1 NOX4 HIF1A RRAS SP1 IL11 JUND MAPK1 IL11RA MGRA MAP2K6 ACE2 PTPN11 COL1A2 TGFBR2 PDGFD AGTR1 IL6ST OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH3 NOTCH1 DMP1 HNF1A BMP7 KLF4 DSPP ALPL RUNX2 SP7 SOST CTNNB1 DKK1 NOTCH2 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies GSK3B SMAD2 CREBBP TGFB1 RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 WNT7B CEBPD CTNNB1 CDK4 MAOA SPP1 APC CSNK1A1L NOTCH1 PPARG WNT10B HDAC1 LEF1 TNFRSF11B PS1TP5BP1 ZMPSTE24 FNTA CTSK LMNA HES1 EMD JUNB HES5 TCF7L2 CDKN1A TCF7L1 ICMT RB1 HMGA2 DICER1 LEMD3 TARBP2 GDF8 KAT2B BMP2 MYOD1 AGO2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG MAFK COX1 NFE2L2 PTGS2 CYP2A6 VEGFA JUN FOS NFKB1 IKBKB NFKBIA KEAP1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members GSK3B CREBBP EP300 CHUK ZC3HAV1 RELB TBK1 IKBKG BTRC SKP1 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CLDN6 MAVS MAP3K14 RIGI NFKBIA ERN1 PARP1 NFKB2 IKBKB LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS TLR4 ICOSLG CD40 CD80 TNLG7A IL6 CD40LG IFNA2 TNFRSF13C BCR TLR9 IL17A TLR7 PDCD1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 TGFBR1 IL10RA SLC7A7 LHFPL2 HIMAP2 GAPT NRROS GPX1 RGS1 HEL-S-62p C1QC SPP1 CD84 ITGAM FKBP15 NCF2 PLEK LOXL3 TCIRG1 PPP1R18 CXCL16 PYCARD LYL1 RPS6KA1 CREB3L2 ITGAX CD37 GAL3ST4 IL13RA1 RNASE6 IL18 HEL-S-66 TNFRSF1B RUNX3 LGALS9C APBB1IP MAF TYROBP BIN2 ELF4 NPC2 DPYD EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance EGFR PDGFA NRAS BRAF IGF1 VEGFA IGF1R SRC KDR SHC1 PDGFRA PDPK1 MYC HGF AKT3 RRAS2 NRG1 ERBB2 NRG2 EIF4EBP1 MAPK1 SOS2 KRAS MET MAPK3 SHC4 SHC2 MAP2K1 SHC3 PDGFD MAP2K2 TGFA BCL2L11 ERBB3 PDGFC BCL2L1 EIF4E BCL2 EGF RAF1 AXL RPS6KB2 FGFR2 RPS6 RPS6KB1 PRKCB IL6R PRKCA PIK3R3 CCND1 GSK3B PIK3CD STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA IL6 RRAS BAD MTOR PIK3R2 PIK3R1 FOXO3A NF1 FGF2 PTEN JAK1 HRAS GRB2 SOS1 FGFR3 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGS2 PPARG PTGFR HEL-S-298 EHHADH HPGD PTGDR2 CYP4A22 AKR1B1 PLA2G5 PLA2G6 NR1C2 PTGS1 TBXA2R PTGDR PTGIR PTGIS PLA2G4B CYP4F2 CYP4A11 PTGR1 CYP4F12 ACOX1 PRXL2B ACOX3 PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IF2B1 TLR4 IL23R RORC RORA SMAD2 NOD2 IL2RG IL-21 TGFB1 HLA-DMA STAT1 STAT3 IL18RAP TBX21 STAT4 IL21R IL12RB1 IL10 JUN IFNGR1 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL2 IL4 IL6 IL5 TLR5 TNF IL12A IL18 IFNG IL23A IL17F MAF IL1A IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling PIK3CD MAPK8 TGFB1 STAT3 GAB2 VAV1 JUN SRC SHC1 CXCL8 IL5RA MAPK1 CSF2RB CRKL FYN MAPK3 INPP5D BAD ENPP3 PTPN11 CCR3 MAP2K1 LYN PIK3R2 SYK PTPN6 PIK3R1 IL3 IL3RA BCL2L1 BCL2 RAPGEF1 CD69 RAF1 YWHAQ CBL HEL-S-1 FOS JAK1 STAT5B HRAS GRB2 SOS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NFKB1 SP1 MAOA GPX1 HEL-S-44 MAPK14 HEL-75 CYBB GCLC MGST1 GSTT2 NFE2L2 TXN2 UGT1A3 XDH NQO1 GPX3 TXNRD2 NOX3 CYP1A1 NOX5 JUNB FOS NOX4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 FABP6 SLC10A2 ABCB11 ABCC2 SLC51A SLC51B ABCB1 ABCC3 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI LATS1 TEAD4 LATS2 HDAC3 NF1 HDAC1 SIN3A MERTK SKIL TEAD2 TEAD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ECHS1 ACSF3 ACAT1 PCCA PCCB DBT MLYCD BCAT2 MCCC1 IVD ACADSB BCAT1 DLD HSD17B10 ACAD8 MCCC2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development NOTCH1 EGFR SMAD4 MAPK9 FGFR2 FOXC2 FOXC1 MAP3K1 INHBB BMP4 JUN SHH SFRP1 DKFZp781O1323 PITX2 FGF10 DKK2 MAPK3 SMAD1 TGFA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 MAPK10 MAPK9 MAPK8 RPS6KA2 MAP3K1 JUN IFITM1 IFITM2 RPS6KA3 MAP2K3 MAPK1 MAP2K4 MAPK12 DDIT3 MAP2K6 MAPK3 MAPK13 BST2 ATF2 MAPK11 MAP2K1 MAPK14 IFI27 MAP2K2 MAP3K10 MAP3K11 EIF4E BCL2 RAF1 RPS6KA1 JUNB FOS FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway GSTM2 MTTP APOB ACACA MLXIPL ABCC2 FASN PPARGC1B SLC27A5 FOXA2 FOXO1 ABCC3 INS SLCO1B1 IRS1 FOXA1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B1 ABCC2 ABCG2 BCHE CYP3A4 CES2 UGT1A10 CES1 ABCC1 UGT1A1 UGT1A9 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 WNT3 LRP6 FZD3 WNT3A NEUROD1 CCND1 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 TICAM1 PARP1 TRADD FADD MAPK8 FTL CASP8 TNF RIPK3 TNFRSF1A CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2 SMAD4 RELA EP300 CHUK STAT3 RELB IGF1 CEBPB IKBKG IGF1R TNFRSF1A NFKB1 IL6 TNF RPTOR MAPK11 MTOR NFKBIA MLST8 FOXO3A AKT1S1 TWEAK IL6R MAP1LC3A TRIM63 TNFRSF12A NFKB2 IL1R1 IKBKB FBXO32 ACVR2A IL1B REL JAK1 GDF8 IL1A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment BDNF SHC1 PDPK1 EIF4EBP1 PTPN11 NFKBIA BCL2L11 EIF4E RPS6KB2 RPS6KB1 MAPK8 STAT3 BAX CASP8 RAPGEF1 FADD TRADD IKBKB RAC1 SMPD1 HRAS PAK1 NRAS MAP3K1 CTNNB1 MYC IRS1 MAP2K4 MAPK1 KRAS MAPK3 MAP3K5 MAPK11 MAP2K1 HEL2 MAP2K2 BCL2 RAF1 BMP7 LEF1 PRKCH PRKCB PRKCE PRKCA TCF7L2 TCF7L1 ARHGAP35 CFL2 PRKCI TIAM1 PARD3 MAPKAPK2 CYCS RTN4R IQGAP3 GSK3B HEL-S-15 NPTX2 PIK3CD MAP2K5 PRKCZ NGFR CASP9 EEF2 TP73 DOCK7 CHUK WASL APAF1 EEF2K TRAF6 CRK PLCG1 IKBKG ROCK1 ROCK2 JUN HEL-S-47e PARD6B PIK3CA PARD6A MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 LIMK1 ARHA BAD MTOR CDC42 FOXO3A YWHAQ HEL-S-1 YWHAG YWHAZ CREB1 FRS2 GRB2 SOS1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FGFR2 PIK3R3 MAPK10 MAPK9 MAPK8 FZD10 PTCH1 SMAD1 PIK3R4 PIK3R2 PIK3R1 SMO FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 SMAD4 RUNX2 STAT1 FGFR4 BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 WNT5B NOTCH2 NOTCH3 NOTCH1 PRKCH PRKCB PRKCE PRKCA WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PRKD1 BMP2 MYOD1 WNT2B PIK3CD PRKCZ WNT16 PIK3CA MAPK7 LRP5 LRP6 IHH RBPJ FGF7 FGF8 FGF9 SOX9 HES6 PRKDC PIK3R5 JAG2 FZD4 SMAD9 FGF18 FGFR1 PPARG PIK3C2G PIK3C2A GLI3 PIK3C2B HEY2 FGF2 WNT9B FGF7B WNT9A FGF7A WNT8A WNT8B DLL3 DLL4 HES3 MAPK6 HES2 MAPK4 FGF5C FGFR3 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling NLRP3 MMP9 IRF7 KLRD1 TGFB1 CCR2 VEGFA NFKB1 IL6 CSF1 CXCL8 TNF CCL2 PYCARD IL12A IFNG IL1B IL17F PTGER4 CXCL9 IFNA1 AHR PTGER2 CXCL1 IL17A AREG CCL3 IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP ASCL1 CXCL2 MBP MYT1 SOX8 SOX6 IGF1 SOX5 NKX2-2 BMP4 SHH NKX2-6 MOG LIF OMG OLIG1 OLIG2 SOX10 TNF SOX9 FGF2 IL1B BMP2 CXCL1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A FAN1 CREBBP CHRNA7 ARHGAP11B GOLGA8R CCL5 MTMR10 KLF13 OTUD7A FYN GPR75 GOLGA8O KAT2B GOLGA8Q TRPM1 FANCD2 GRM6 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKB1 MUC1 IL6 IKBKB CHUK RELA TNF NFKBIA IKBKG MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CCNG1 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER1 ADCY3 PTGER3 ALOX12 LTC4S PTGS2 GNAI1 ALOX5 ALOX15B ALOX15 ALOX5AP NRAS KRAS GNAS MAPK11 SIRT1 IGFBP5 PTGS1 CDKN1A RB1 PTGIS PTGER4 HRAS PTGER2 PRXL2B PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes ADCY1 HDAC2 EP300 EZH2 PRKAA2 SIRT1 AHR RORC MAPK10 RORA MAPK9 MAPK8 CSNK1D C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC HTR7 CSNK1E PROK2 HEL-S-80p AgRP PROK1 CHRNB2 UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CARTPT MTNR1A CLDN4 MTNR1B PSPC1 TIMELESS UTS2 SIK1 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM TNFRSF11A NPAS2 RAI1 AANAT UBC NKX2-1 DRD1 PTEN DRD2 DRD3 PPARGC1A DRD4 HDAC3 EGR1 SIN3A ZFHX3 OPN4 OPN3 HOMER1 NONO GFPT1 NR1D2 NR1D1 BTBD9 NR2F6 SETX STAR ID2 ID4 HNRNPD ID3 FBXL3 PML SLC9A3 TCF2 OGT ADA TPH2 TOP2A TPH1 KDM5A SUV39H2 CHRM1 SUV39H1 FAS BHLHE41 CDK4 NR1C1 HEBP1 RBM4 DBP JUND SIX3 HEL-S-2 KLF10 KCND2 SFTPC PAX4 MC3R SFPQ NCOR1 ADORA2A THRAP3 MTTP CRY2 KCNMA1 CRY1 AVP NLGN1 PRKAA1 PHLPP1 CIPC HDAC1 CRX RBM4B TYMS NPS PROX1 ATOH7 PROKR1 NFIL3 GNA11 NOCT RPS27A NTRK1 ARNT2 F7 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HS3ST2 HCRTR1 PER2 ATF5 PER1 PER3 ATF4 MYBBP1A GSK3B GHRH LEP KLF9 GHRL NGFR BMAL2 RELB BTRC ROCK2 SKP1 JUN IL6 DDC NOS2 PRKDC NAMPT PPARG TH CREB1 CRH GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other GPR17 P2RY11 HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 CCR2 OR2A5 LGR6 OR2A4 ADGRL2 GPR18 ADGRL3 OR7E24 ADORA2A GPR83 PTGFR CHRM2 CHRM3 OR1G1 OR2M4 GPR61 C5AR2 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 HTR7 EDNRA GPR176 GPR132 GNRHR CCR5 GPR135 UTS2R ADGRV1 ALG6 OR1F1 F2R OR2H1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 SMO GPR162 CCKBR OR5AC2 FSHR ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 ADRB2 IL8RB MCHR2 GHRHR DRD3 FY CXCR1 DRD4 CNR1 CXCR3 S1PR1 OR2B6 NTSR1 OR5D3 P2RY13 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p RB1 PRKAA1 HEL-S-133P HEL-S-30 HEL-S-162eP RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism HEL-S-53e CYP2A6 CYP1A1 ADH1A RPE65 DHRS4 CYP3A7 SDR16C5 CYP2W1 RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT BCO1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PLCB1 CRTC2 INSR PRKAA2 EIF4EBP1 RPTOR PRKAG1 PRKAG2 SLC2A4 ADRA1B ACACA ELAVL1 ADRA1A FASN RPS6KB2 PRKAG3 PPARGC1B NR2A1 PRKAA1 GYS2 GYS1 LIPE PRKACG LEPR PRKAB2 STRADA RPS6KB1 STRADB CPT1C PRKAB1 CCNA2 CAB39 PIK3R3 ADIPOR1 ACACB ADIPOR2 CAMKK1 CCNB1 CAMKK2 INS-IGF2 SLC2A4RG STK11 LEP PIK3CD TSC2 EEF2 TSC1 EEF2K HMGCR PIK3CA CPT1A MTOR PIK3R2 PIK3R1 CDKN1A IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG STAT1 STAT3 CISH GAB2 SHC1 IL2 SOCS3 MAPK1 CRKL FYN MAPK3 PTPN11 MAP2K1 MAP2K2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 CBL RPS6KB1 JAK1 STAT5B PTK2B HRAS JAK3 NMI GRB2 LCK IL2RA SOS1 IL2RB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL15 F2RL1 IL2 ITGB7 EGFR DHODH IFNG IL-21 TNF NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF2S1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway STAR RUNX2 CXCL2 FOXO1 DKFZp781O1323 PDPK1 SLC1A2 EIF4EBP1 MAPK1 TNF MAPK3 PTPN11 MAP2K1 MAPK14 MAP2K2 SLC2A4 EIF4B DYNLT1 BMP7 NFE2L2 DYNLT3 PRKAA1 RPS6 RPS6KB1 PRKCB GNA11 PRKCE PRKCA HIF1A CAMKK2 HCRTR2 HCRTR1 PRKD1 LEP GHRL CASP9 PRKCZ MAPK9 MAPK8 CASP3 GNAI1 STAT3 IL10 MAPK7 IL4 NPFFR1 IL6 DAGLA CXCL8 FSHB SGK1 LHB BGLAP NPY SMAD1 GNAS NPVF VHL MTOR CGA PIK3R2 HCRT PIK3R1 OPRK1 GCG CCK POMC GH1 IL9 GNRH1 ARRB2 TH RPS6KA1 BMPR1A NOX4 CREB1 IL1B MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP16 MMP9 PRKD3 MMP15 MMP23B PRKCZ SCN8A MMP17 MMP19 BDNF NOS2 SNAP25 AGER SLC2A3 PRKCH MMP21 MMP20 PRKCB MMP25 MMP24 PRKCE MMP27 SCN9A HEL-S-62p PRKCA MMP28 MMP7 TRPA1 MMP2 MMP3 SORD TRPV1 PRKCI MMP10 PRKCQ MMP12 MMP11 SCN10A MMP14 CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR TXN AMD1 APIP MAT1A SMS MRI1 IL4I1 MSRA MTAP ADI1 CHDH MSRB2 MSRB3 ENOPH1 SRM HEL-S-61p HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA TFAP2A ARHGAP29 ARHGEF2 IRF6 TP63 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KDR PDGFRA PDPK1 HGF PRKAA2 MET RPTOR MLST8 PDGFC SLC2A4 EIF4E EIF4B EGF ELAVL1 RPS6KB2 FGFR2 GYS2 GYS1 RPS6 LIPE STRADA RPS6KB1 RHEB AKT1S1 CAB39 HIF1A JAK3 STK11 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 ULK1 PIK3R4 PIK3R2 PIK3R1 IL3RA MDM2 SLC2A3 PTEN IKBKB JAK1 HRAS EGFR FGFR4 NRAS VEGFA FGF10 CSF1 IRS1 IRS4 MAP2K1 MAP2K2 FOXA1 HEL-S-125m TCL1B TCL1A ACACA PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 PELO CDC37 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 HIF3A GNGT2 FGF8A RAB8A OSMR COL2A1 KIT PHLPP2 COL11A2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD RAB11B NGFR COL3A1 CASP9 KITLG GHB3 CSF3 CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 PFKFB2 PFKFB1 CSF1R PFKFB4 EFNA5 EFNA4 CHAD FGF20 NOS2 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 FGF16 EFNA3 FGF14 EFNA2 PIK3R5 COL5A3 COL5A2 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 ITGB4 PIK3C2A FLT4 LAMC2 PIK3C2B ITGAE FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C ANGPT4 ANGPT2 ITGB1 LAMB3 ANGPT1 PRL LAMB2 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PRLR PPP2R2B PPP2R2D EIF4EBP1 GHR CDKN1B ITGB3 ITGA2B LAMC1 IBSP IL6R ITGA2 COMP COL1A1 LAMA5 THBS1 VTN SPP1 LAMB1 SLC2A2 PPARGC1A CRTC2 TNC FLT1 INSR PDGFA IGF1 FOXO1 IGF1R INS CHRM1 AKT3 MAPK1 KRAS MAPK3 ATF2 COL1A2 PDGFD PRKAA1 PHLPP1 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 F2R GNB3 ITGAM GNGT1 CREB3L2 ITGAX CREB3 CREB1 ATF6B INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 AKT3 SNCA APP STAT1 CEBPB SRPK2 BACE1 SET BDNF TARDBP MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 BRAF JUN ALK KSR1 SHC1 FOS GAREM2 MYC KRAS SOS2 MAPK3 MAP2K1 MAP2K2 SOS1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR CREBBP HDAC2 RELA EP300 NFATC1 NFKB1 HDAC5 SUPT4H1 HDAC8 SP1 HDAC9 HDAC7 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 NFKBIA CDK9 PPP3R1 PPP3R2 HDAC1 NELFB NELFCD NELFA PPP3CA HDAC3 PPP3CC TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 TDO2 NMNAT1 IDO1 NMRK2 NMRK1 NAPRT NAMPT AADAT HEL-S-90n HAAO KMO KYNU NMNAT3 AFMID NMNAT2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RPS6KA2 SHC1 PDPK1 SOCS3 SOCS1 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 PTPN11 SHC3 SLC2A4 EIF4E RPS6KB2 INPPL1 CBLC RPS6KA4 GYS2 RPS6KA6 GYS1 LIPE RPS6KA5 GRB14 GRB10 ENPP1 MAP3K8 RPS6KB1 MAP3K6 RHEB GYG1 MAP3K7 INPP4A TRIB3 STXBP3 PIK3R3 STXBP4 RRAD PPP1R3A KIF3A STX4A RAB4A EHD1 EHD2 MAP3K12 ARF1 HEL-S-31 SNAP23 PTPRF FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 TBC1D4 SGK2 ARF6 SNX26 MAP4K3 MAP3K2 HEL-S-42 PFKL MYO1C PFKM SGK1 PIK3R4 PIK3R2 PIK3R1 RAPGEF1 XBP1 MAP3K13 GSK3A PTEN IKBKB RAC1 EGR1 HRAS INSR MAP3K1 FOXO1 IGF1R RPS6KA3 IRS1 MAP2K3 IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 HEL-S-61 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 PRKAA1 PRKCH PRKCB PRKCA PRKCI PRKCQ GSK3B PIK3CD MAP2K5 PRKCZ CRK JUN PIK3CA MAPK7 SH2B2 MAP3K14 MTOR SNAP25 STXBP1 FOXO3A PIK3C2G PIK3C2A CBL RPS6KA1 FOS MAPK6 MAPK4 GRB2 SOS1 VAMP2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 TSC2 TSC1 EEF2K NRAS BRAF GAB2 PLCG1 BDNF GRIN1 SHC1 TRPC6 TRPC3 ARC NTRK2 DLG4 EIF4EBP1 MAPK1 KRAS MAP2K1 MTOR RPS6KA1 RPS6KB1 RHEB CREB1 HRAS GRB2 HOMER1 SOS1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades TFPI APOA2 C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 NR1C1 SP1 GPAM STAT3 CYP1A2 CYP1B1 NR0B2 ACOX1 CYP1A1 JUN PCK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2A CAMK2G GRIN1 ARC MAPK1 MAPK3 RYR2 NLGN1 NLGN3 CYFIP1 NLGN2 YWHAG NRXN1 FMR1 NRXN3 NRXN2 GRIN2B RPH3A SYNGAP1 DLGAP1 TJP1 DLG2 SHANK1 CAMK2D HOMER1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 NFKB1 IL18 IL6 MAVS IL1B CSF2 TNF CGAS RIGI CXCL9 MITA CCL2 IFIH1 CXCL11 IRF3 TLR8 TLR7 TLR3 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT1A8 UGT2B7 ABCC2 UGT1A3 UGT1A10 UGT1A1 ABCB1 UGT1A9 ABCC3 SLCO1B1 CYP3A4 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling GSK3B TRAF3IP2 IL17RC IL17RB RELA STAT3 IL17RA TRAF3 TRAF6 CEBPB IKBKG CEBPD PIK3CA NFKB1 SP1 MAPK1 MAP3K14 MAPK3 NFKBIB IL25 MAP3K7 IKBKB IL17F IL17D JAK1 IL17C IL17B IL17A ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 UGT1A3 NQO1 CYP1A2 GSTM1 CYP1B1 UGT1A1 SULT1A1 STS UGT1A9 SULT1E1 CYP1A1 ARSL CYP3A4 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTX1 SPRYD4 CDKN2A AP3D1 TRMT1 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 TRIP13 LAMTOR3 LAMTOR5 LY6K PLXND1 TUSC2 GEMIN2 LTN1 CPOX ARID4B CALCOCO2 MSI2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 VPS39 KPNA3 EIF4E FADS1 AXL MYLIP ATG3 TNLG5A TPM3 TPM1 STX7 GYS1 UBE4A ATG9A CDKAL1 RAB30 GPD2 TMEM59 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 RAB5C CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP NPRC GAS2L1 SAC3D1 MCL1 CCND1 MPDU1 CD164 VCAM1 BRPF3 HMGA1 SLC4A10 TNFRSF10A NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 BCL6 TRPV6 UBE2S CHMP2A SRPRB MENT DKFZp761E1322 PICALM SLC25A1 DOCK5 ADPGK TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 PTBP1 SMAD1 DNMT3B TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 PPP3R1 UTP15 HSDL1 RBM19 SIGMAR1 ARID1A TXN2 NT5C3A RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 UNC93B1 NXN UHRF1 PLAG1 HSD17B12 MRM1 AURKB GNA13 DNAJB1 CAND1 PPP3CA POLR2C RAB23 TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT ABCF2 SLC25A22 PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 IRS1 MAPK12 MAPK14 TCL1A PPIF MTRR LPL RTN4 KIT PRKCI IQGAP3 DOCK7 RARS1 COL4A2 HEL-S-26 HEL-S-47e MAPK7 CDK6 E2F3 LAMC2 FGF2 P4HA2 NELFCD CDKN1A PPP2R5C PPIB BDNF CDKN1B MAP3K8 LAMC1 SMC1A C1QBP SUCLG2 TNFRSF10B ITGA2 SNAP23 PTPRF CAP1 ATAT1 SYPL1 TUBA1A FBXW11 GPAM DDX5 CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 ATP6V1F GFPT1 ATP6V0E1 CPNE8 VEZT SERPINE2 TMEM41B EHMT1 CLDN1 PWP1 ABCG2 DCAF7 RRP8 PNP DHX57 KRAS LOC541469 CHORDC1 RAVER2 MYB CIAO2A SEC62 GOLGA7 NOTCH2 CDK5RAP3 HOXA5 NOTCH1 BCL2 ARL10 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 OTULINL POM121 HACD3 MRPL20 BACH1 FXR2 COMMD9 TERT RDH10 GRPEL2 CEP72 KCNN4 VTI1B SNX6 SLC38A1 GSTM4 PHC2 HARS1 RAB27B BRI3BP PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B FERMT2 HOXD8 RNP24 RCOR1 CDKN1C NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MEOX2 MRC2 PANX1 COIL CHAF1A SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC ANXA2 MRPS24 ELOVL5 ATP2A2 ELMOD2 AP2A1 TMT1A AP3B1 PRPF40A RHOB SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN PTRH1 VAMP3 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG HEL-S-66 PTPA PURA NT5E PGRMC1 PPP1R7 USP1 SHOC2 TAF9B SRSF10 MPZL1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation TLR4 IL10 CCL11 TMPRSS2 IL12A FURIN IL2 HMGB1 IL4 IL18 IL6 GFAP IFNG CXCL8 IL1B MAPK1 TNF IFNA2 ACE2 TLR8 TLR7 IL1A TLR3 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling GSK3B IL7R IL2RG STAT1 STAT3 IL7 MAPK1 STAT5B FYN MAPK3 JAK1 BAD PTK2B JAK3 MAP2K1 MAP2K2 PIK3R2 PIK3R1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 KLKB1 BDKRB1 SERPING1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development ID2 ASCL1 ID4 MBP MYT1 SOX8 SOX6 NFIA SOX5 NKX2-2 EGR2 BMP4 SHH NKX2-6 PDGFRA OLIG1 OLIG2 SOX10 MYRF CHD8 PTN ZNF24 SMAD1 NFATC2 DUSP15 SOX2 NKX6-1 SOX9 ZNF488 LGI1 OPALIN SOX11 ZBTB33 ZEB2 BMP1 TMEM98 CNTN1 CSPG4 WNT10A FGF2 HES5 TCF7L2 PRKCA RELN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 MTOR FOXO1 IGF1R NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC18A2 DDC MAOA SLC6A3 PNMT TH TPH2 DBH TPH1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 ALPL HEL-S-302 PLPBP ALPI HEL-S-1a PIGV DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CSNK1A1 FOXO1 CDK4 DCAF7 RPTOR DEPTOR MLST8 CRY2 NOTCH1 CDKN1B SIRT1 PSEN1 LIN54 NEUROG2 GMNN HES1 DNER AKT1S1 LIN52 RBL2 HES5 RBL1 TFDP1 TFDP3 AMPH LIN37 LIN9 RBBP4 E2F5 EIF2B5 REST CCND1 TFAP4 SPRY2 GSK3B CASP9 TSC2 APP CASP3 TSC1 NFATC1 E2F4 MTOR DYRK1A TFDP2 CDK6 FGF2 CREB1 H3F3B LATS2 PSENEN BACE1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK1 IRAK2 IRAK4 MAPK10 IRF7 SAFB MAPK9 TAB3 MAPK8 MYD88 RELA CHUK MBP TRAF6 MAP3K1 MAP3K7IP1 NFKB1 MYC MAP2K3 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB EIF4E RPS6KA5 MAP3K8 MAP3K7 FOS IL1R1 IKBKB MAPKAPK2 TANK IL1A GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 EGFR OTUD5 DGIC AHCTF1 LBR DSCC1 CHTF18 MTDH CHTF8 BRIX1 TOP2A RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 MYC RNF144B LMNB2 UBE2T SNURF S100A6 CD48 CEBPZ COL9A1 COL9A3 RAD17 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 ITGB1 SMAD2 HEL113 FLT1 RELA CXCL2 CDH2 VEGFA SNAI2 IGF1R DKFZp781O1323 SRC KDR SHC1 PDGFRA CTNNB1 CLDN1 PDPK1 SOCS3 RPS6KA3 SOCS1 PRKAA2 MAPK1 TNF MAPK3 CCL2 MAP2K1 MAPK14 MAP2K2 ACACA ZEB2 RAF1 RPS6KA4 SP7 RPS6 RPS6KA5 RPS6KB1 PRKCB IBSP HEL-S-133P HEL-S-102 GSK3B ACTA2 MAPK9 MAPK8 TGFB1 CSF3 PLCG1 IL10 COL4A1 JUN NFKB1 IL6 CXCL8 CRKL CPT1A BGLAP SIX1 SMAD1 CXCL5 HK2 MTOR DUSP4 CLDN5 SLPI PIK3R1 PCNA MST1R SMAD6 KLK15 PARP1 SMAD9 FZD1 FGFR1 WNT10B NR0B2 RPS6KA1 FOS PTEN IFNB1 TJP1 IL1B PPARGC1A CSF2 EGR1 GRB2 CXCL1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders HIST1H2BE TERF2IP TPP1 H2BC21 H2AC19 H2AX H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 ACD H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 TINF2 H2BC1 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H3-4 H2BC15 H2AC20 H2BC11 POT1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP FPGS UPP2 TDG TK1 RRM1 RRM2 ABCC5 GGH SMUG1 DHFR UCK2 UCK1 ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 XRCC3 CYP2A6 CES2 CES1 TYMS ABCC3 DPYD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination SOX8 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 WNT4 SRY RSPO1 AMH FGF9 SOX9 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway MAPK8 PAK1 CHUK STAT1 STAT3 WASL PDGFA MAP3K1 PLCG1 VAV1 VAV2 JUN SRC SHC1 NFKB1 MAPK1 MAP2K4 ARHA MAPK3 PTPN11 MAP2K1 NFKBIA COX2 PIK3R1 CDC42 RAF1 FOS RAC1 JAK1 HRAS TIAM1 GRB2 SOS1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease NOTCH3 HEL25 MEF2C HP1BP3 HSPB3 HSPB2-C11orf52 tmp_locus_29 LBR H2AZ1 LMNA ACTA1 MYOD1 MYOG DMPK AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 GLUD1 HAL GPT2 FTCD MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids PIK3CA CERS1 NFKB1 HIF1A ASAH2 TSC1 S1PR3 S1PR1 MTOR CERK SPHK2 IGF1R TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 MEF2C MEF2B CDKN2A CCND2 STAT3 BCL6 ID3 EZH2 IL21R NFKB1 MYC IL6 TLR5 TNFRSF13C BCR LYN TLR9 SYK TLR7 BCL2L1 ICOSLG CDKN1B CD40 SPI1 CD79B SPIB CCND3 CD79A POU2F2 TLR1 IRF4 POU2AF1 IRF8 TCF4 TLR10 TCF3 CDKN1A TLR8 TLR3 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD MAPK8 PAK1 STAT3 STRN ARAF NRAS BRAF CRK PLCG1 JUN ALK SRC PIK3CA RAP1A HGF AKT3 MAPK1 KRAS SOS2 CRKL MAPK3 MET BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 PIK3R1 CDC42 RAPGEF1 RAF1 CBL PIK3R3 CDKN1A PRCC RPL11 ELOA PAK6 RAC1 INSL3 PAK4 HRAS C8orf34 JAK3 GRB2 SOS1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R11 PPP1R10 PPP1R2 PPP1R8 PPP1R16B MAPK8 MBTPS1 PPP1R14A PPP1R14B PPP1R14C PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B HEL-S-89n PPP1R3E PPP1R1C PPP1CC PPP1R1B PPP1R3D PPP1R12B HEL-S-80p PPP1R14D PPP1R12C MBTPS2 DDIT3 PPP1R9A ERN1 BCL2 XBP1 EIF2AK2 MAP1LC3A PPP1R3A PPP1R7 EIF2AK1 EIF2S1 PPP1R15A PPP1R15B PPP1R13B ATF4 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOB LDLR APOE APOC2 LPL APOC3 APOA2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway FASN RXRA CYP3A4 NR1H3 CYP2B6 ABCG8 ABCG5 SCD CYP7A1 IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling IL9 IL2RG STAT1 STAT3 MAPK1 STAT5B MAPK3 JAK1 JAK3 MAP2K1 GRB2 MAP2K2 CDK9 IL9R PIK3R2 PIK3R1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway CDKN2A KLF4 CEBPA TREM1 CYP3A4 NFATC2 SLC2A4 ADRA1B CDKN1B TPM1 CD40 CDKAL1 IL25 IRF4 IRF8 IL12A NR1C2 HIF1A CCND1 TRAK1 TGFB1 ALOX5 BCL6 TRPV6 THBD BDKRB1 BGLAP SPP1 CYP7A1 GADD45A STEAP4 LPGAT1 CCNC GXYLT2 PRDM1 KNG1 CLDN2 SALL4 TNFSF11 LGALS9 EPHB4 SULT2A1 KRT71 SLC34A2 CCNE1 S100A2 ABCB1 MED9 CYP1A1 LCE1F LCE1D LCE2B CDC34 NINJ1 S100A4 S100A9 S100A8 TNLG2B COL13A1 CLEC16A KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 FGF23 HLA-DQA2 HLA-DQA1 KL SLC37A2 KRTAP12-2 KRTAP8-1 BMP6 CYP2S1 ID4 TRPV5 PNOC ID1 CLPTM1L STS MXD1 ALPG ZNF257 FOXO1 SPRR1B SFRP1 CD200 HLA-DRB1 ORM1 HILPDA TNFAIP3 MYC CYP27B1 ORM2 ADAMTS5 CDK2 SULT1C2 RXRA CASP14 DUSP10 NR1i1 ADGRE5 CASP5 DACT2 TIMP3 ATP2B1 CTLA4 SOSTDC1 KRTAP5-1 CA9 ABCD1 SLC8A1 CAMP HNF1A KRTAP5-4 KRT34 CEACAM1 CYP2C9 KRT38 DEFB4B CYP2B6 COLEC11 SATB1 TNFRSF11B PTH ALPI HEL57 IGFBP1 SEMA3B ASAP2 IGFBP5 CST6 PTHLH DNER IL1RL1 JUNB CST1 CLMN CREG2 HSD17B2 CDKN2D LRRC25 S100G KRTAP10-2 CDKN2B KRTAP10-4 PRKCQ CDKN2C CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CYP24A1 KRT16 CD9 CBS LRP5 EFNA5 S100A6 ITGAM ADRB2 CDKN1A PTGER4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins PLCB4 TERF2IP PRKCZ MAPK9 CADM1 CSN3 GRIK2 GPHN CDH2 RAP1GAP CHL1 EPB41L3 NCDN CAMK2G MAP4 NEO1 CLASP1 GRIN1 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 EFNA5 GABRG2 SNW1 DAB1 AGRN ATP2B1 KCNQ2 KCNMA1 CASK STX2 GRIN2B MAPK4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PPARGC1A SIRT1 IGF1 PRKAB2 MTOR EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling MEF2C CAMK2A RPS6KA2 MEF2D GAB2 VAV1 NEDD4 VAV2 SRC SHC1 PDPK1 ERBB2 EIF4EBP1 SOS2 PTPN11 COX2 EGF INPPL1 CBLC RPS6KA5 GRB10 RPS6KB1 STAT5B PTK2B MAP4K1 MAPK9 MAPK8 STAT3 ARF6 MAP3K2 RAP1A CRKL INPP5D PIK3R2 PIK3R1 PTEN RAC1 JAK1 HRAS RALA EGFR PAK1 STAT1 BRAF MAP3K1 FOXO1 RPS6KA3 JUND MAPK1 KRAS ATF1 MAP2K1 MAPK14 MAP2K2 RAB5A RAF1 GJA1 PRKCB PRKCA PRKCI SPRY2 HEL-S-15 MAP2K5 PRKCZ CRK PLCG1 ROCK1 JUN MAPK7 CAV2 SP1 USP6NL SH3GL3 ERRFI1 MTOR NDUFA13 PLCE1 SH3GL2 STXBP1 RALBP1 PCNA CDC42 HGS STAMBP RIN1 STAM2 SH2D2A AP2A1 IQGAP1 FOXO4 PLD2 ATXN2 TNK2 PIK3C2B PTK6 CBL SYNJ1 AP2S1 RPS6KA1 HEL-S-34 PXDN NCK2 NCK1 VAV3 EPS15L1 FOS EPN1 AP2M1 PLSCR1 ARHGEF1 RALB CREB1 ASAP1 NEDD8 MAPK4 REPS2 RICTOR CSK LIMK2 GRB2 ITCH FOSB SOS1 PTPN5 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 CALM1 PDE3B RYR2 ADCY3 ADRA1B MYLK ADCY1 ADORA2B ADCY8 ADRA1A PDE4A ADCY6 PDE3A RYR3 ADRA1D PDE4B PDE4D HEL-S-80p PPP1R12C ADCY9 ADORA2A NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation ITGB1 HDAC2 HDAC10 HDAC11 DMBX1 ASCL1 CDH6 MPZ CDH2 ZIC1 MBP HOXA1 ID1 FOXD3 SNAI1 SOX5 MSX2 SNAI2 MIA BMP4 OLIG3 PAX3 ISL1 DCT OLIG1 PAX7 CTNNB1 OLIG2 HAND1 HDAC5 MYC SOX10 HOXB1 CTBP2 HDAC8 GFAP DLX5 HDAC9 TWIST1 HDAC7 HDAC6 PRTG GBX2 MSX1 TFAP2A MYB TFAP2B ZIC5 TBX6 NOTCH2 PHOX2B NOTCH3 GJB1 NOTCH1 TLX2 LHX1 PMP22 BMP7 LHX5 NEUROG1 FGFR2 HDAC1 HES1 TCF4 DVL1 HES5 FGF8A DVL2 DVL3 TCF7L1 NFKB2 COL2A1 WNT1 COL11A2 WNT3A GSK3B AXIN1 AXIN2 NFKB1 RBPJ SMAD1 FGF8 SOX9 FGFR1 RHOB FZD3 HEY2 FGF2 WNT8A DLL3 DLL4 HDAC3 FGFR3 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN1 GRIN2B DLG4 NLGN1 GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 NLGN3 NLGN2 NRXN1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCB4 PLCH1 PLCH2 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 PIP4K2A PLCG2 PLCG1 PIK3CA MTMR10 INPP5D PIK3R4 PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 IL2 SPN CD27 CD3G CD3E CD3D CD80 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 RAD9A CDKN2A CASP9 CASP3 BAK1 TP73 APAF1 BAX YAP1 MRE11A MDC1 TRAF6 RIF1 SMC3 KAT5 TRIM28 HSF1 RAD50 TP53BP1 RAD51 BLM ACTL6A RASSF1 NABP2 MCPH1 ATF2 FANCD2 PCNA PRKDC PARP1 H2AX MDM2 ATM NBN ATR SMC1A RNF8 BRCA1 TERF2 LATS1 BRCA2 RAD52 CDK5 CHEK2 RAD17 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production HMGCR FDFT1 PDIA2 DGAT1 APOA5 SQLE APOC2 APOC3 SOAT1 ABCG8 APOC1 ABCG5 CYP7A1 LIPC APOA2 ACSS1 APOA4 SCARB1 MTTP APOB LDLR PLTP APOE LPL ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EP300 ACKR3 HGF CYP2C19 CYP3A7 NRG1 CYP3A4 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 AHR CYP4F12 ACOX1 CCND1 IL2 APOA5 GCC1 TNS4 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 MGST1 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 ABCB4 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 CYP1A1 SLC19A2 SLC2A3 GSTM3 PLK2 ABCC3 SMARCA1 SLCO1B1 HEL-S-128m SLC6A5 SLC6A7 ABCB11 SLC6A8 SLC6A9 DNAJB1 CPEB4 GSTM5 SLC6A1 SLC6A2 EPB41L4B ENC1 ANKRD1 TGFBR2 NCOA1 SLC2A14 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 EGFR SLC2A10 TSC22D3 SLC2A13 PTGS2 SLC2A12 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 BAAT POU5F1 SLC7A5 B3GNT5 CDC42EP3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF NR1I3 FGD4 TNF SRPX2 GPR153 SERTAD2 CAP2 CCL20 CAVIN2 PTGES3 GSTM2 NR1i2 NR1H4 CYP8B1 KTN1 FASN FABP1 GSTA5 GSTA4 SLC27A5 GSTA3 SLC6A3 SLC27A1 CDC37 NR3C1 SLC39A9 UGT1A1 EPHA2 SLCO2B1 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 DNER SLC39A3 AIP ALDH3A1 FGF8A SCNN1A FKBP5 NFKB2 SLC26A2 ABHD2 IP6K3 DNAJC15 SLC2A9 ALAS1 SRXN1 SLC2A6 SLC2A7 SLC2A8 ARL5B CPT2 ZIC2 ME1 PDK4 POLK ACADM SRGN GPX2 HEL-S-25 HEL-S-22 TGFBR3 DNAJC7 NAV3 ADGRF4 BIRC2 BIRC3 SLC5A12 SLC5A10 PRRG4 UGT1A4 STOM UGT1A7 TXNRD3 S100P SPRY1 ADH7 PCK1 KLK15 FGF13 HSP90AB1 ABCC5 SRC DBI CCL2 APOA2 PLTP CDKN1B IL12B SMC1A IL12A IFNG GADD45B CDC2 IL17B TGFB1 STAT3 PPP1R14C BAX ALOX5AP TXN SERPINA1 THBD APOC3 CPT1A ABCG8 ABCG5 SCD CYP7A1 GPAM SULT2A1 CYP1A2 CYP1B1 NR0B2 ABCB1 BHLHB2 SLC2A2 SLC5A1 SLC5A2 SLC6A20 SLC5A5 PPARGC1A EGR1 UGT2B4 SLC6A19 UGT2B7 ABCC2 SLC6A18 GSTM1 SULT1A1 SNAI2 SLC5A8 FOXO1 CDK4 TNFAIP3 NR1C1 MYC IL11 RXRA JUND NR1i1 HEL-75 GCLC NFE2L2 CYP2C9 RGS2 CYP2A6 CYP2B6 EHHADH IGFBP1 HES1 JUNB SLC7A11 FTH1 NR1H3 SLC39A8 GSTM4 KAT2B KEAP1 MAFG SLC39A14 FTL CDKN1C JUN HMOX1 SP1 MAFF GCLM PDE4B AMIGO2 PTPA IL1B NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling GSK3B HDAC2 EP300 STAT3 SKP1 SRC NFKB1 MAML2 SNW1 MAML1 FHL1 DTX1 RBPJ MAGEA1 CIRSR MTOR SPEN PIK3R2 SAP30 NCOR1 NOTCH2 PIK3R1 HES6 NCOR2 NOTCH3 NUMB NOTCH1 APH1B FBXW7 ADAM17 MAML3 JAG2 PSEN2 HDAC1 PSEN1 HEY2 HES1 DLL3 HES5 DLL4 PSENEN ITCH LCK DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MARCHF5 DNAJC19 TIMM8A TIMMDC1 USP9X STAT2 PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 C1QBP AIFM1 MCL1 TRAK1 MFN2 PARK2 VCP UFD1L MIPEP UBXN1 CLPB TXN2 PLEK FLJ10842 MICOS13 OPA1 OPA3 GDAP1L1 TXNRD2 LONP1 SACS PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CDKN2A RELA ZAP70 IRF2BPL GRAP2 HLA-DRB1 TYK2 LTA PDPK1 LCP2 CARD11 BCL10 CCL19 MAPK1 PTPRC TNF HLA-DRA FYN MAPK3 CCL28 LAT RPTOR IL18R1 MAP2K1 NFKBIA DEPTOR CTLA4 MAP2K2 MLST8 BCL2L1 RAF1 CD80 RHEB IL12B IL12A IFNG IL23A PRKCQ CCND1 LCK IL17A GSK3B IL23R PIK3CD TSC2 MYD88 CD3G CD3E CHUK TSC1 CD3D BAX STAT4 IFNAR2 IKBKG PLCG1 IL12RB1 JUN NFATC1 IFNAR1 NFKB1 IL2 IL4 MTOR PIK3R1 ICOS FOXO3A FOS CDKN1A PTEN IFNB1 IKBKB PPP3CC RICTOR HRAS GRB2 SOS1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG2 PRKAG3 PRKAA1 RHOB YAP1 RHO HMGCR CTGF PRKAB2 PRKAB1 LATS1 TEAD4 CYR61 PRKAA2 LATS2 ARHA STK4 TEAD2 RHOD TEAD3 MOB1A PRKAG1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 ACE2 AGTR1 AVPR1B ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer EGFR BAK1 NRAS BRAF CTNNB1 PDPK1 MYC AKT3 ERBB2 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 HEL-S-28 CTNNA1 CTNNA3 EGF RAF1 CTNNA2 FGFR2 LEF1 DDB2 PIK3R3 TCF7L2 TCF7L1 GADD45B GADD45G CCND1 GSK3B PIK3CD POLK CASP9 ARAF BAX AXIN1 AXIN2 PIK3CA BAD GADD45A APC PIK3R2 PIK3R1 FGFR1 FOXO3A FGF2 FOS CDKN1A PTEN HRAS APC2 GRB2 SOS1 FGFR3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 STAT2 MYD88 CHUK STAT1 TRAF3 TRAF6 TBK1 IFNAR2 IKBKG JUN TYK2 NFKB1 IFNAR1 MAVS RIGI MAPK14 NFKBIA TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 RIPK1 MAP3K7 FOS TICAM1 IKBKB JAK1 IFIH1 IRF3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDKN2A EGFR SMAD2 SMAD4 PAK1 BAK1 RELA STAT1 BRAF VEGFA TGFBR1 RAD51 CDK4 AKT3 ERBB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 TGFA BCL2L1 EGF RAF1 RPS6KB2 dik RAC3 E2F2 RPS6KB1 DDB2 PIK3R3 RB1 PAK6 PAK4 GADD45B TIAM1 GADD45G CCND1 PIK3CD MAPK10 POLK CASP9 MAPK9 MAPK8 TGFB1 CHUK STAT3 ARAF BAX IKBKG PIK3CA NFKB1 ARHA BAD MTOR GADD45A PIK3R2 PIK3R1 RALBP1 CDC42 CDK6 E2F3 HEL-S-34 CDKN1A RALB BRCA2 IKBKB RAC1 JAK1 TGFBR2 RALA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 IDO1 GOT2 IFNA6 KYAT3 KYAT1 IL6 DDC IFNB1 IFNG AADAT IL1B HAAO TNF KMO KYNU AFMID IDO2 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development MEF2C NKX2-5 SMAD4 FOXC2 FOXC1 VEGFA BMP4 SHH NFATC1 ISL1 PITX2 CTNNB1 FGF10 HAND1 GATA4 MAPK1 NFATC3 SMAD1 NFATC2 PTPN11 FGF8 NFATC4 ERBB3 NOTCH1 FOXA2 HEY2 BHLHB2 BMPR1A BMP10 GATA6 BMPR2 TBX20 SMYD1 TBX1 FOXH1 IRX4 TBX5 TBX2 HAND2 BMP2 VEGFB VEGFC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 LAMB3 LAMB2 PTGS2 BAK1 RELA TRAF3 CDK4 MYC AKT3 RXRA CDK2 NFKBIA NFKBIB BCL2L1 BCL2 CDKN1B ITGA2B E2F2 LAMC1 DDB2 CCNE2 PIK3R3 RB1 CKS1B CDKN2B GADD45B ITGA2 TRAF1 TRAF4 COL4A3 GADD45G CCND1 TRAF5 CKS2 CYCS RARB COL4A5 BIRC7 PIK3CD FHIT POLK RXRB CASP9 LAMA5 RXRG LAMB4 CASP3 CHUK APAF1 BAX TRAF2 TRAF6 IKBKG COL4A2 BIRC2 CDKN1C COL4A1 BIRC3 SKP1 COL4A4 PIK3CA COL4A6 NFKB1 MAX CASP8 NOS2 GADD45A PIK3R2 PIK3R1 LAMB1 CDK6 E2F3 LAMC2 CCNE1 ITGAV CDKN1A PTEN IKBKB ITGA6 LAMA1 LAMA4 LAMA3 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MMP9 MEF2D EZH2 SHC1 TWIST1 SOS2 PIK3R3 HIF1A COL4A3 COL4A5 MAPK8 SPARC TGFB1 TUSC3 HEL-S-79 FOXQ1 FZD10 CDKL2 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 JUP PALS1 VTN NRP2 PKD1 CLDN22 CLDN20 CLDN24 CLDN23 EED CLDN11 CLDN10 CLDN15 PIK3R2 CTDSP1 PIK3R1 CLDN14 CLDN19 STRAP CLDN4 CLDN18 CLDN2 CLDN17 CLDN16 TMPRSS4 FZD1 NR2C2 WNT10B SUZ12 WNT10A GDF15 FZD3 NUBPL CRB3 FZD2 FZD5 FZD7 FZD9 FZD8 TJP1 MMP2 LATS2 HRAS TGFBR2 MMP15 SMAD2 SMAD4 PAK1 ID2 CDH2 FOXC2 ID1 SNAI1 FMNL2 SNAI2 FOXM1 TGFBR1 WNT7B WNT7A CTNNB1 CLDN1 AKT3 MAP2K3 MAP2K4 MAPK1 MAPK12 KRAS MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 RAF1 ZEB2 PROX1 WNT1 WNT3 WNT4 RBBP4 WNT3A GSK3B WNT2B PIK3CD TRAF6 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA LRP5 CLDN6 LRP6 RBPJ CLDN5 JAG2 FZD4 WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 GRB2 SOS1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 CYB TTC19 UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MAP1B BIRC5 TUBA2 MYH9 ERG EGFR SMAD2 STUB1 MAPRE1 AURKA HEL113 CFTR HDAC11 ITIH4 EP300 NEDD9 HTT KALRN ATXN3 ADRBK1 EP400 CCDC141 SHH POU5F1 FUS BDNF MIIP TARDBP ARID3A ISG15 BBIP1 CTNNB1 GARS1 CNOT6 HEL-S-2a HDAC9 TWIST1 MAPK1 HDAC6 MAPK3 MAP3K5 HEL-S-44 CYBB BCL2 GRIA2 NR3C1 PXN PRKCE MAP1LC3A SQSTM1 OPTN HIF1A HEL-S-102 PTK2B HEL-S-32 MIF GSK3B DCTN1 PRKCZ MAPK8 RHOT1 MYD88 BAX PARK2 KAT5 VCP HSF1 CSNK2A2 FOXP3 TUBA1C DLG4 SP1 SGK1 CSNK2B VHL APC TUBB HEL-S-72p APOE TUBA4A HEL-S-67p GSK3A SNCA HSPA4 DLG2 RAC1 IKBKAP CDC20 FREP1 SNCAIP CD133 FAT10 SIRT2 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EGFR PRL CHUK CEBPA PRLR NFIA CEBPB TFPI2 MYC CSN2 ERBB2 NRG1 CLDN6 YY1 ERBB4 DLGAP4 PTPN1 USF2 TTC9 NR3A2 GJB2 GAL ERBB3 NFIB ELF5 BCL2L1 EIF4E ORAI1 PGR HDGFL2 USF1 EIF4G1 TNFSF11 TPM3 NR3C1 TNFRSF11A STAT5B CCND1 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 CDKN2A SUMO1 TNFSF10 TP73 BBC3 OTX2 BAX BOK MDM2 ATM CDKN1A MYC PMAIP1 GADD45A TP63 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 SP1 MAPK1 MAPK3 RBPJ TLR9 CYBB CDC42 NOTCH1 NCF2 DOCK6 CYBC1 NCF1 NOX3 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 KCNN3 C4orf54 DLL4 GTF2I BEND6 EFL1 CYBA SHCBP1 RAC1 IBTK ARHGAP31 EIF6 SBDS BTK TLR8 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ADCY3 ADCY8 SLC16A10 SHH FOXO1 SRC KDM1A CTNNB1 AKT3 RXRA MAPK1 ATF2 RPTOR MAP2K1 MAPK14 MLST8 NOTCH1 RAF1 ITGB3 RPS6KA6 RPS6 RPS6KB1 RHEB AKT1S1 WNT4 THRA AQP7 GSK3B TRH TTF2 TTF1 NPPB ITPR2 MC4R CASP9 NHSL1 TSC2 DUOXA2 SLC16A2 TSC1 TBC1D4 TSHB ACTL6B SECISBP2L DIO1 SIRT6 SLCO1C1 ADRB3 PAX8 PIK3CA MAPKAPK3 ZNF516 PLIN1 PFKFB2 MGLL KDM3B AgRP UCP1 NR1A2 PRDM16 DUOX2 DEHAL1 NPY BAD MAFA FGF21 TSHR MTOR TG SLC26A4 TPO PNPLA2 POMC PPARG FGFR1 MDM2 ITGAV CREB3 FRS2 SLC5A5 PPARGC1A HRAS GRB2 SOS1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK10 MAP2K5 MAPK9 MAPK8 RPS6KA2 CSNK2A1 PIK3CA AKT3 MAP2K3 EIF4EBP1 MAPK1 MAP2K4 MAP2K6 MAPK3 RPTOR MAP2K1 MAPK14 MTOR MAP2K2 PIK3R2 EIF4A2 PIK3R1 EIF4A1 PIM1 EIF4E PIM2 EIF4B RPS6KB2 EIF4G1 RPS6KA4 RPS6 RPS6KA5 RPS6KA1 RPS6KB1 PIK3R3 PRKCA THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK9 MAPK8 RELA STAT1 STAT3 RELB STAT4 GAB2 SRC NFKB1 EIF4EBP1 MAPK1 FYN MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA LYN MAP2K2 TEC YES1 IL7R TSLP FES CRLF2 RPS6 NFKB2 JAK1 STAT5B BTK LCK SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida MAT1A MTRR MTR AHCYL2 MTHFD1 SHMT1 DNMT3B 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome SLC35G3 RPL23 SRCIN1 SLFN12 CACNB1 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 TCF2 SLFN5 CCL13 GRB7 CCL11 GGNBP2 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 CCL5 ERBB2 CCL7 ZNHIT3 LYZB C17orf78 CCL2 CCL4 CCL1 ASIC2 TEC CCL18 RFFL GAS2L2 SOCS7 ACACA CCL16 LHX1 HEATR9 CCL15 TAF15 TMEM132E RASL10B PCGF2 SYNRG EPOP FNDC8 PEX12 PLXDC1 NLE1 ARHGAP23 TBC1D3K STAC2 TCAP CDK12 SPMAP1 PIP4K2B PNMT PPP1R1B DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I MRM1 AATF IKZF3 MMP28 CISD3 DUSP14 TBC1D3H CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 UNC45B MED1 CCL3 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 HEL-S-130P PDX1 CTNNB1 MSRA GATA4 MAPK1 MAPK3 NKX6-1 SLC2A4 RAF1 BMP1 MTMR8 MTMR9 NUMA1 MTMR6 TERT PINX1 HEPACAM2 TBX5 SOX7 SLC35G5 PRSS55 NEIL2 BLK CSTA MCRS1 TNKS PRSS51 S100A10 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 FAM167A FCGR2A FCGR2B AXIN1 XKR6 PPP1R3B FDFT1 CLDN23 SLBP ERI1 TERF1 SGPL1 CGAS HSPD1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA VEGFA ERBB4 MGRA ADAM10 SMC1A MAT1A BMP2 SH2D4B FAM25A BUB1B SMC3 ADIRF LDB3 GHITM IQUB WAPAL NFKB1 ROPN1L RSPH6A ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 SH3GL3 DYDC2 DYDC1 ZMYND11 RGR RSPH9 PDS5B PDS5A GPR15LG RAD21 SNCG TNFSF11 GPR15 PPARG SUSD2 RSPH3 GLUD1 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 BMPR1A LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 OPN4 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 RPE PRPS1L1 DERA OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP9 CNTF CXCL2 CCL14 CCL13 CCL23 CCL11 CCL3L3 LIF LTA CX3CL1 CCL8 CCL5 CCL19 CCL7 CCL28 CCL2 CCL4 CCL1 CCL18 CCL16 CCL15 IL25 IFNA6 IL12B TNLG7A IL12A IFNG IL23A IL17F IL17D IL17C IL17B IL17A IF2B1 IL15 IL-21 TGFB1 CXCL12 IL10 IL13 IL2 IL4 IL5 CXCL8 SPP1 IL3 IL9 CSF2 MMP3 IL1RN CXCL17 CXCL13 IF2D CXCL11 CXCL14 IF2G IL36A IL1A IL36B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 EBI3 IL36RN IFNA21 IF1AA9 TNFSF13 IL36G PPBP VEGFA IFNW1 IL1F10 CXCL6 IL24 IF1IB1 IL27 CXCL3 IL7 IFNA8 CSF1 PF4V1 IL11 IL19 XCL2 TNF IFNK XCL1 CTF1 IFNL2 IFNL3 CCL17 CCL20 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 IFNA7 OSM CSF3 EPO NFKB1 IL6 IFNA2 CXCL5 TSLP CXCL16 CCL4L2 IL18 IFNB1 IL1B CXCL9 IFNA1 CXCL1 AREG CCL3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 FADD CASP9 CASP3 BAK1 APAF1 DIABLO BAX TNFSF6 CASP6 PRF1 FAS HTRA2 CASP8 AIFM1 CYCS TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors EIF1AX EEF2 EIF2S2 SUI1 EIF3S3 EEF2K EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF4EBP1 EIF4A2 EIF4A1 EIF4E EIF4B EIF4G1 GSPT2 EEF1B2 EIF4H EIF4EBP2 EIF4EBP3 EIF2AK2 EIF2B1 PAIP1 EIF5A EIF5B EIF2B3 CLUH EIF2B2 EIF1AY EEF1A1 EEF1G EIF2AK1 EIF6 EEF1A2 EIF2B5 ETF1 EIF2S1 PABPC1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E PIK3CD RAF1 TSC2 PRKAA1 TSC1 PIK3CA PIK3R3 MAP2K3 EIF4EBP1 MAPK1 MAP2K6 MAPK3 MAP3K5 MAP2K1 MTOR MAP2K2 HEL164 PIK3R2 MAP3K11 PIK3R1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y2 DUX4 MYF5 EP300 VEGFA PAX7 TRIM63 ADRB2 CDKN1A MYC FBXO32 PPARGC1A NR3A2 MYOD1 MYOG RET H3Y1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation TAF5 MIXL1 HOXA1 EZH2 PAX3 RGS10 CTBP2 GATA4 ZIC5 LHX1 ELAVL1 SESN1 LAMC1 GATA6 TCF4 C1QBP FOXH1 SOX7 PLCH1 APP TGFB1 TBX21 CRTC1 PIAS1 NABP2 DKK1 DNMT3B MAD2L2 BMPR1A NKX2-1 CAND1 SIAH2 SMAD2 SMAD4 SLC2A12 STAT1 TET1 TCF2 FOXO1 POU5F1 SFRP1 CUL4B CTNNB1 MAP2K3 SOX2 FOXA1 NOTCH1 ACACA BMP7 OTX2 FOXA2 NR3C1 LEF1 PTHLH TCF7L1 WNT3 PABPC1 WWC1 SOX21 SOX17 CEP250 CER1 WDHD1 SFMBT1 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF CEBPZ ATP8B2 PBX3 FOXN3 GDF3 DUSP4 APC ZFHX4 TRERF1 PBX1 EXT1 SP4 PAF1 TAF4B NODAL TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 JARID2 DUSP5 VAV3 DUSP2 WNT8A NOG PARP8 NR1B3 TOX3 AEBP2 Pax9 AHDC1 BTAF1 TCEAL2 LEO1 KDM4A ZNF462 ELP4 LRPPRC TNRC6C ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway PLAGL1 EGFR CD36 KLF6 NCOA7 PTGS2 RELA EP300 NRAS VEGFA SRC NFKB1 AHRR MYC CDK2 MAPK1 TNF KRAS FGF21 CCL1 MAP2K1 NCOR2 GCLC RAF1 NFE2L2 CDKN1B LPL NQO1 CYP1A2 NF1 CYP1B1 CDC37 CYP1A1 AIP CDKN1A RB1 HRAS AHR RET GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG INS IL6R IL6 GLP1R SLC2A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP INSR STAT3 LEPR INS PDPK1 PIK3R3 SOCS2 DGKZ SOCS3 SOCS1 IRS1 IRS4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 REN MGRA ACE2 AGTR1 DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SCN8A PRR5 MAPKAP1 KCNA2 CHD2 PCDH19 SCN3B SCN3A SCN1B SCN1A PIK3CA SNTA1 NFKB1 SCN2A SCN4B SCN2B HCN1 TNF MAPK11 MTOR STXBP1 MLST8 CALM1 FGF13 PRKCA RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB1 PLCB2 GNAI1 S1PR3 PIK3C2B GNAI3 SPHK2 SPHK1 MAPK7 PLCB3 AKT3 MAPK6 SMPD2 MAPK1 S1PR2 MAPK4 MAPK12 S1PR5 MAPK3 S1PR1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MEF2C CAMK2A TET2 CNP CTCF TET1 MBP EZH2 IGF1 FUS IGF1R CEBPD BDNF TARDBP GRIN1 DLX5 PSIP1 YBX1 CDON RBFOX1 HEL-S-20 TAP1 NCOR1 POU3F2 HNRNPH1 GPRIN1 TET3 DLX6 FOXG1 NREP FUT8 PRPF38A RPS6 GAD1 HDAC1 GRIA3 IGF2 GRIA4 POU4F1 SST HNRNPF TAF1 FKBP5 REST SP3 BCL6 MYT1 SMC3 UBE3A SP1 SGK1 APOC2 MTOR OPRK1 NF1 FGF2 FGF7A PTEN CREB1 FGF5C SIN3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SC5D DHCR7 HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB COL5A3 COL5A2 LAMB2 COL3A1 ITGB5 COL4A2 COL4A1 LAMC1 ITGB6 THBS1 SDC2 ITGA1 COL6A1 LAMA4 COL1A2 THBS2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling GSK3B PDHA1 CYP24A1 TSC2 TSC1 RELA CD80 IL10 SLC2A3 PIK3CA IL12A MYC PFKFB4 HEL-S-133P RXRA PRKAA2 NR1i1 HK3 HLA-DRA MTOR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling CIP2A RGMA DCSTAMP MYF5 COL1A1 CASP3 YAP1 CTGF IL10 JUN NEO1 SRC PIK3CA KDR AGAP2 MAPK1 TNF ARHA FYN MAPK3 INPP5D CCL2 PTPN11 MAP2K1 MAPK14 MAP2K2 SELE PPP2R1B RAF1 ALPL ITGB4 PRKCA PTPA RAC1 ROBO4 NTN1 PTK2B RLF NTN3 PLEKHH1 ARHGEF12 VCAM1 UNC5B IL1A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5 NRF CD8B1 CD3G PRG3 CD3E CD2 IGLL1 CD8A CRP LBP ZAP70 MMP25 HLA-DRB1 IL6 CXCL8 HLA-DRA FYN LCK FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia EGFR MRE11A DCLRE1B CTDP1 UHRF2 FAAP24 CEBPD BRIP1 RAD50 SLX4 RAD51 MEN1 FANCM CENPX FANCL REV1 UBE2T FANCA FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C FANCD2 RFWD3 ERCC1 HEL-S-125m CENPS MCM2 SMARCA4 FAN1 MAD2L2 ATM NBN ATR UHRF1 PTEN BRCA1 BRCA2 USP1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IRAK1 PDLIM7 MAPK8 CHUK RELA TRAF6 IKBKG MAP3K7 NFKB1 TRADD NFKB2 IFNB1 CXCL8 IKBKB CCL5 MAPK1 TNF MAP3K14 TRAF1 NFKBIA CCL20 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA MAFG FBL CREBBP IRF2 SMAD4 HEL23 DDX21 CREB1 FOXO1 NPAS2 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling MEF2D STAT1 TRAF2 MAP3K1 TGFBR1 SHC1 MAX MYC MAP2K4 DDIT3 MAP2K6 MAP3K5 ATF2 MAPK14 SMIM40 CDC42 RASGRF1 HMGN1 MAPKAPK5 RPS6KA5 RIPK1 MAP3K7 TRADD CREB1 RAC1 HEL-S-102 HRAS GRB2 MAPKAPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHS1 ACSL5 ACSL3 ACACA FASN PECR MECR PC ACSS2 ECHDC1 ECHDC2 DECR1 ACLY ACACB SCD ACSL1 ACSL6 FACL4 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway MASP2 HEL-S-62p C3AR1 FCN1 C6 C7 COLEC11 C9 ACE2 C5AR1 C8A ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP IL2RG CRLF2 STAT3 IL25 FCER1G IL13 IL1RL1 FCER1A TYK2 MS4A2 IL13RA1 IL4 IL5 OSMR JAK3 IL33 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways MAT1A NNMT TPMT INMT PNMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ME1 BCAT2 HMGCR PFKL ACLY SLC7A5 DLD SOAT1 KRAS HEL-S-30 HK2 GNPNAT1 PDHA1 LDLR GOT2 FASN CS GLUD1 PDHX RPIA GLS2 RPE PGM3 HEL-S-133P DLAT GPT SLC16A4 CARM1 HEL-S-32 GFPT1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG2 PDHA1 ACACA FASN PRKAG3 PRKAA1 LIPE PRKACG ACSS2 PRKAB2 ACLY PRKAB1 HILPDA PLIN1 AKT3 PRKAA2 PRKAR1B PRKAR1A ABHD5 PNPLA2 PRKAG1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR4 IRAK4 IL2RG TGFB1 STAT3 CD80 TRAF6 NFKB1 IL4 NFKB2 SOCS1 CCL5 CCL2 TGFBR2 CTLA4 IL2RA TLR8 TLR7 IL2RB PDCD1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA PRKDC CHAF1B NASP MCM2 HAT1 ASF1A ASF1B H4C9 HIST1H4L CHAF1A RBBP4 SUPT16H XRCC5 SMIM40 SSRP1 CHEK2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP2A6 XDH CYP1A2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TLR4 MMP9 IRF7 CREBBP STAT2 EP300 EGR2 SRC TYK2 SOS2 NFATC3 NFATC2 NFATC4 IKBKE IFNA6 MAP3K7 DDB2 PIK3R3 STAT5B PTK2B JAK3 MAPK10 MAPK9 MAPK8 TGFB1 STAT3 ARAF BAX STAT4 NFATC1 CXCL8 CASP8 VDAC3 PIK3R2 PIK3R1 FADD IKBKB CASP12 JAK1 HRAS IFIH1 TGFBR2 IRF3 TLR3 IFNA13 BIRC5 IFNA14 IFNA16 SMAD2 IFNA17 SMAD4 IFNA10 TICAM2 HSPG2 RELA STAT1 IFNA21 DDX3X TRAF3 IF1AA9 CASP10 BRAF TIRAP NRAS DDB1 MAP3K1 TGFBR1 MAP3K7IP1 FAS MYC IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 KRAS MAP2K6 MAPK3 MAPK13 ATF2 MAPK11 MAP2K1 MAPK14 MAP2K2 BCL2 RAF1 CREB3L3 CREB3L4 TNFSF6 PRKCB IFNA7 TICAM1 PRKCA CYCS ATF4 IRAK1 PIK3CD IRAK4 CASP9 MYD88 CASP3 CHUK APAF1 TRAF6 TBK1 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD PCNA YWHAQ HEL-S-1 CREB3L2 FOS YWHAZ CREB3 CDKN1A IFNB1 CREB1 CREB5 IFNA1 GRB2 SOS1 ATF6B NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A5 MYH9 LAMB2 MYO1E SCARB2 SMARCAL1 CD151 HEL-S-47e PTPRO COL4A4 GPC5 APOL1 TRPC6 SYNPO YARS EMP2 ALG1 WDR73 COQ6 ARHGAP24 COQ2 PAX2 WT1 CD2AP INF2 NPHS1 CTLA4 CYP11B2 PLCE1 ACTN4 NPHS2 COQ8B LMX1B E2F3 ITGB4 ZMPSTE24 LMNA CUBN COL4A3 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 THRAP3 MORC3 ELL BCLAF1 SETX STK38 TRIM35 RBBP7 SUZ12 EZH1 EZH2 JARID2 AEBP2 RBBP4 EED COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 HEL-S-78p F13B PLG F13A1 FGA BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage TNC REN TCF2 BMP4 SFRP1 DKFZp781O1323 KDR PAX2 WT1 RSPO1 NPHS1 NPHS2 NOTCH2 NOTCH1 LHX1 HNF1A tmp_locus_29 BMP7 NR2A1 CITED1 TCF21 SALL1 SIX2 RSPO3 DACT1 EMX2 FOXD1 OSR1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 WNT4 TBX18 NTN1 GDNF TLX1 FAT4 DCN VSX2 ACTA2 EPO AXIN2 SIX1 SMAD1 FGF7 FGF8 PBX1 NT5E IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 IDO1 GOT2 IFNG AADAT TNF KMO KYNU KYAT3 KYAT1 IDO2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF PGR FOSL1 MYC HEL113 ERBB2 CCND1 TIMP1 AREG HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC RBX1 CBFB NAE1 UBA3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B PTPRN CAMK2A SCN11A PDCD10 SCN7A SCN8A SCN5A PRRT2 MAPK8IP2 SCNM1 SCN4A RNF121 NEDD4 SCN3B SCN3A WEE1 SCN1B SCN1A SCN2A SCN4B SCN2B TNF FYN FGF14 CALM1 FGF13 FGF12 PSEN1 SCN9A BACE1 SCN10A ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC5 CDKN2A BAK1 TRAF3 CASP10 FAS MAPK3 MAP3K5 NFKBIA BCL2L11 SMIM40 BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO PIDD1 TNFSF6 CASP6 RIPK1 AIFM2 IL1R1 PMAIP1 TNFRSF10B AIFM1 BLK PRKD1 MCL1 CYCS IRAK1 BIRC7 TNFRSF10A CASP9 MAPK8 MYD88 CASP3 APAF1 BAX TRAF6 HRK TNFRSF6B BIRC2 CAPNS1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 PTRH2 MADD TNFRSF25 NAIP BCL2A1 BCL2L10 CASP8 BAG3 MAP3K14 BMF CRADD BAD BIK BNIP3 TNFRSF10C SEPTIN4 PTPN13 TNFRSF10D BCL2L2 FADD FOS TRADD IKBKB TNFRSF1B HTRA2 IL1R2 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling CREBBP HDAC2 CTBP2 MAML1 DTX1 RBPJ NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 APH1B ADAM17 MAML3 RBPJL JAG2 CTBP1 DTX2 DTX3 PSEN2 DTX4 LFNG KCNJ5 HDAC1 DTX3L PSEN1 KAT2A MFNG HES1 DLL3 DVL1 HES5 DLL4 DVL2 DVL3 KAT2B METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX12 PTGS2 ALOX5 ALOX15 FADS2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 RPTOR MAPK11 MAP2K1 MAPK14 MAP2K2 PRKAG1 MLST8 PRKAG2 PRKAG3 PRKAA1 PRKAB2 RPS6KB1 PRKAB1 CDC2 EEF2 EEF2K MTOR CALM1 UQCRB COX7C RPS6KA1 RAB5IF MOSMO UQCR11 NDUFS8 UQCR10 CYB NDUFS3 COXFA4 CDH18 UQCRH COX5A UQCRQ TRPM7 UQCRC1 PDZD9 UQCRFS1 CDR2 CYC1 NDUFA9 SDR42E2 UQCRC2 VWA3A POLR3E FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 RPS6KB2 TSC2 FSHR RPS6 RPS6KB1 FOXO1 RHEB SRC PRKCA FSHB CREB1 EIF4EBP1 MAPK1 SGK1 MAPK3 H3-4 APPL1 MAPK14 MTOR CGA PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 BIRC5 PTGS2 RELA CHUK CXCL2 RELB TRAF6 VEGFA BIRC2 BIRC3 TNFRSF1A NFKB1 IL2 IL6 CXCL8 BCL2A1 TNF SELE BCL2L2 NFKB2 CD40LG IKBKB EGLN2 MMP2 IL1B CSF2 MMP3 REL CCND1 VCAM1 IL1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C8 NR1C1 PPARG CYP4F2 CYP4A11 CYP4F12 CYP2C18 EPHX2 CYP4A22 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C2 NR1C1 CD36 CYP2C9 NR1i1 NPC1L1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A ADCY1 ADCY8 GNAI1 ARAF PPP1R1A GRIN1 PPP1CC RAP1A HEL-S-80p MAPK1 MAPK3 GNAS MAP2K1 MAP2K2 GJB1 CALM1 RAF1 ACTG1 GRIA2 GRIA3 PS1TP5BP1 PRKACG GRIA4 PRKCB PRKCA DRD1 DRD2 CREB1 DRD4 ACTG2 CAMK4 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 UGT2B7 AKR1D1 AKR1C1 AKR1C4 AKR1C2 UGT1A10 CYP11B2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB4 PLCB1 CACNA1A PLCB2 GRIA2 GNA14 RYR3 HOMER3 CA8 GRIA3 GRIA4 GNA11 TRPC3 GNA15 PLCB3 ATP2B2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 NFKB1 TGFB1 RASGRF1 STAT3 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling GSK3B MAPK9 MAPK8 CASP3 RELA CHUK TRAF3 RELB TRAF2 BIRC2 BIRC3 JUN NFKB1 CTNNB1 MAPK1 TNF CASP8 MAP3K14 MAPK3 MAPK14 NFKBIA NFKBIB FADD RAF1 HDAC1 RIPK1 MAP3K7 TWEAK TRIM63 TNFRSF12A NFKB2 IKBKB RAC1 TRAF1 TRAF5 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP9 SMAD2 CACNB1 SMAD4 MCUB SCX TOMM20 SLN TGFBR1 SGCA CAPN3 TRPC1 TRDN STIM1 CASQ1 TNNI1 DMD CACNG1 PRKAA2 PLA2G2A TNF FKBP1A SSPN SNTB1 NFKBIA AGTR1 CYBB ORAI1 PPIF CACNA2D1 PRKAA1 MPO CACNA1F FGA HEL-S-78p CACNA1S MCU DAG1 ATP2A1 ITPR2 CASP9 TGFB1 PRG3 CTGF IL10 TRPC6 SLC25A5 NFKB1 TRPC3 IL6 SPP1 NOS2 ELANE RYR1 SIGMAR1 NOX4 MMP2 IL1B CAMK2D TGFBR2 IL1A CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2C TLX2 MEF2B KLF4 ID2 MEF2D STAT3 RUNX2 EZH2 PAX7 HDAC5 LEFTY1 TLX1 SOX2 TLX3 MYOD1 LEFTY2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway RAF1 MAPK8 STAT1 STAT3 MAP3K1 PLCG1 JUN PRKCB EIF2AK2 PIK3CA SHC1 FOS PRKCA MAP2K4 STAT5B MAPK3 JAK1 HRAS MAP2K1 GRB2 SOS1 PIK3R1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT2B MAPK10 MAPK9 MAPK8 WNT7B WNT16 WNT7A CTNNB1 LRP5 LRP6 ARHA INVS WNT5B NPHP3 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT9B FZD7 FZD9 FZD8 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A ID2 ARCN1 ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B FLT3 ZBTB16 PYGO1 BCL9 WIF1 SALL4 RARA RUNX1T1 LEF1 PML CSNK1A1 AXIN2 NR1C2 JUP CTNNB1 TCF3 DKK1 MYC LRP5 WNT1 LRP6 CCND1 APC SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK GPX2 RELA DIO1 JUN NFKB1 TXNRD3 SP1 GPX1 CTH FABP1 NFE2L2 RPL30 HEL-S-134P SELENOF GPX3 SELENOI TXNRD2 SELENOH SEPHS1 CREM SEPHS2 PSTK EEFSEC POU2F1 GPX6 FOS TRNAU1AP SELENOO SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SELENOW GPX4 SELENOV SELENOT SP3 MSRB1 SELS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias FECH UROD UROS HMBS CPOX ALAS1 ALAS2 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EGFR ADAP2 HOXA1 MAP3K1 RAD51 OMG MAPK1 MAPK3 SUPT5H BCL2 EGF CRY1 RAF1 RBBP7 EZH1 CCNA2 CCNE2 SDC2 MCL1 PER1 RTN4R HEL-S-15 RAD9A WDR48 NGFR HOXA9 H3C8 EXOC8 EXOC7 RFC2 MYT1 ARF6 POLRMT EXOC4 EXOC3 MAP3K2 EXOC6 ROCK2 RFC3 EVL RFC4 EXOC5 EXOC2 EXOC1 H3C15 INPP5A E2F6 RAB11FIP4 TEFM UTP6 LIMK1 MAVS ATAD5 ARHA RAB11A RIGI EED COPRS EVI2A CRLF3 EVI2B METAP2 PCNA TUBB SUZ12 NF1 CCNE1 JARID2 H4C9 ATR HIST1H4L NGF IFNB1 USP1 SYN1 SOS1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 LEP ACACA ADIPOR1 ADIPOR2 PRKAA1 CPT1A LEPR PRKAG1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 NUP107 NOTCH1 HCTP4 GATD3 KIF15 AURKA SMOC2 CENPF ESM1 RUVBL1 MYBL2 ECT2 KIF20B E2F7 TOP2A H4C9 UBE2C ACTL6A S100P CEP192 H3F3B LIN9 APC INO80D VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 F7 PROC AIFM2 NQO1 PROS1 VKORC1 UBIAD1 F10 F9 GGCX PROZ 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation DAG1 MAPK9 MAPK8 TRAF3 TRAF2 SGCA SNTA1 LINGO1 DMD ARHA SSPN SNTB1 CDC42 MIPEP SACS RTN4 C1QTNF9 SGCD ATXN1 SGCB SGCG TNFRSF19 C1QTNF9B SPATA13 RAC1 TRAF1 TRAF5 RTN4R TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling CREBBP NRAS MAP3K1 MAP3K7IP1 KSR1 TNFAIP3 SMPD2 MAP2K3 MAP2K4 MAPK1 TNF KRAS MAPK3 MAP2K6 MAP3K5 NFKBIA RFFL NFKBIB BCL2L1 RAF1 DIABLO CDC37 MAP3K8 RIPK3 MAP3K7 RIPK1 NFKB2 CYBA REL TRAF1 PPP2CA TANK CASP9 PRKCZ MAPK9 TAB3 PIG59 MAP4K2 MAPK8 CASP3 CHUK APAF1 BAX TRAF2 TBK1 IKBKG BIRC2 BTRC BIRC3 SKP1 JUN CSNK2A1 TNFRSF1A TXN NFKB1 MADD CASP8 MAP3K14 FBXW11 BAD PSMD2 PLK1 FADD TRADD IKBKB TNFRSF1B OTUD7B RAC1 PYGL HRAS KSR2 PTPRCAP NSMAF GRB2 NFKBIE SOS1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence CYP4F8 SLCO2A1 HEL-S-53e DPEP2 ALOX12 LTC4S NAT2 PTGS2 ALOX5 HEL-S-22 ALOX15B ALOX15 ALOX5AP GPX1 FADS2 MAPK11 EPHX2 PTGES3 FADS1 ELOVL5 SIRT1 HEL-S-298 HPGD AKR1B1 DECR1 PTGS1 CDKN1A RB1 PTGIS PRXL2B ALOXE3 ELOVL2 PTGES PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway WNT2B TF NTF4 FST CNTF FLT3LG KITLG TGFB1 INHBA GDF5 EPO PDGFA IGF1 VEGFA BMP4 SHH WNT7B ALK INS FGF10 CSF1R HGF DKK1 IL6 CSF1 IL11 LEFTY1 FGF8 TPO IL3 NOTCH1 EGF TNFSF11 NODAL FGF2 FGF7A NOG IL6R WNT1 KIT NT5E CXCR1 WNT3A FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IRAK1 TLR4 IRAK2 IRAK4 MYD88 TICAM2 RELA CHUK LY96 LBP TIRAP TRAF6 IKBKG SRC PIK3CA NFKB1 CXCL3 IL6 TNF ARHA NOS2 CCL2 SYK ITGAM PLAT PLG FGA IL12B FCER1G TICAM1 HEL-S-78p IFNB1 IKBKB REL TYROBP IRF3 CD14 TLR3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYS2 GYS1 HEL-S-19 PYGL AKR1B1 SLC2A2 GYG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BIRC5 SMAD2 SMAD4 PTGS2 BAK1 DCC BRAF MSH3 TGFBR1 CSNK1A1 CTNNB1 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 BCL2L11 BCL2 RAF1 BBC3 LEF1 RAC3 DDB2 TCF7L2 TCF7L1 PMAIP1 REL GADD45B NTN1 GADD45G CCND1 CYCS GSK3B MAPK10 POLK CASP9 MAPK9 MAPK8 CASP3 TGFB1 ARAF BAX AXIN1 TBK1 AXIN2 MSH6 JUN MSH2 EXOC2 ARHA BAD GADD45A APC CSNK1A1L FOS CDKN1A RALB RAC1 APPL1 APC2 TGFBR2 RALA PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1A2 CAMK2A PDE3B ADCY3 ADCY1 ADCY8 PDE4A ADCY6 PDE3A GUCY1B1 PDE1C PDE1B PDE1A HEL-S-7a GRIN1 PDE11A PPP1R1B PDE6D PDE6C PDE6A PDE8A PRKG1 PDE6H PDE6G PDE2A PDE10A PDE12 PDE5A PDE7B PDE7A ADORA2A PDE9A CHRNA7 PDE4B PDE4D GRIN2B DRD1 DRD2 CREB1 ADCY9 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway CERS5 PLPP1 ACER1 SPTLC3 CERS2 SERINC1 CERT1 ASAH2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 PPP2CA KDSR VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREBBP HLX TRPC1 KDR HEL-S-68p GATA2 ACKR3 PDPK1 PRKAA2 SHC2 MLST8 VPS39 EIF4E TPM3 ADAM10 RPS6 NCL RPS6KB1 PTMAP7 PLA2G5 PXN AKT1S1 ACACB SARS1 CAMKK2 SDCBP PTK2B CCND1 OCRL TBCA EIF3S3 HEL-S-162eP NFATC1 EIF3F EIF3D DKK1 RAP1A CXCL8 CYR61 RAB11A MMRN2 PIK3R2 PIK3R1 RAPGEF1 FADD MDM2 HEL-S-128m NOX4 TEAD4 PPP3CA MMP2 RAC1 HRAS ANXA1 MMP10 SLC2A14 MMP14 ABCF2 PAK1 PTGS2 RELA STAT1 VEGFA FAS CTNNB1 HMGB1 HBEGF MAP2K3 PRKG1 MAP2K4 MAPK12 MAP2K6 MAP3K5 GPX1 MAP2K1 MAPK14 MAP2K2 CYBB RAB5A ERN1 BCL2L1 ACACA RAF1 RPL5 HEL114 RPL7 RPL18A LUC7L UBAP2L CHAC1 EPHA2 EPHB2 RPS11 FGA IER5 EIF2A ACOT9 TMEM170A SND1 INPP4B HEL-S-78p hEMMPRIN KATNAL2 EWSR1 BIN1 TXNIP ALB RPL27 PRKD2 PRKCI RPL26 PPP2CA PFN1 PABPC1 EZR HEL164 ATP6V0D1 MAPKAPK2 CYCS FLII GIGYF2 GSK3B HEL-S-15 DHX36 XB MYO6 MICAL2 PRRC2C LARP7 SRPK1 CALU HYOU1 DHX29 FAF1 KCNC3 CRK CCDC124 ROCK1 SRP54 ROCK2 HBD SHB EEA1 PIK3CA CSRP2 TMSB4X RPLP2 CGNL1 SSR4 SSR3 FJX1 LIMK1 ENG ARHA KANK1 HEL-S-87p CRIP2 SLC7A1 MTOR APOLD1 FGD5 GPC1 FLNB NUMB CDC42 CCT7 BRD4 AAG1 PRKRA TFAM TAOK2 COPG1 FOXO3A GLUD1 FHOD1 ITGB5 CTNND1 PLOD3 RPL10A AMOT CBL EPRS1 tal-1 CCRL2 P4HA2 TMSB10 ITGAV DUSP5 TMOD1 TMOD3 SEMA6D DPM1 FARSB DOK1 DLL4 ARMCX1 RAB37 ADAM9 FRS2 ZNF555 DSC1 LRRC59 HTRA1 FUT1 GRB2 QK3 IGFBP7 ZC3H15 HEL-S-94n SDF2L1 MEF2C HEL-S-84 BMX TPP1 ITGB1 AFDN RCAN1 TFCP2 CNP NR4A3 SPIRE1 GRSF1 MAPKAP1 C15orf39 FHL2 NRARP LDB2 VAV2 RND1 SET CAPZB LRRFIP2 ADAMTS9 SRC SHC1 ARHGEF15 SHROOM2 RPL13A HDAC5 SLC25A11 PPM1G HDAC9 DNAJB4 HDAC7 FAM120A DNAJB9 FYN WASF1 NFATC2 CCL2 SLC25A25 PTPN1 PDE4DIP PTPN11 NFKBIA CDC42BPB FMNL3 PTPN9 PTPN6 CTNNA1 ITGB3 RPS6KA5 GRB10 BMP10 ELOA HEL-S-133P RAB4A PLAUR MAPK9 MAPK8 STAT3 ARF6 CTGF TXN MYO1C HEL-S-99n TUBB8 TUBA1C TRPC3 NRP2 PSMD4 FBXW11 F3 SELE LMAN1 MAPKAPK5 PSMD11 DECR1 SIAH2 EGR1 HEL107 ATP6V1E1 CYP2C8 BIRC5 KL MYH9 ERG TRAF3IP2 FLT1 FOXO1 HEL-S-2a PNP MAPK1 MAPK3 ATF2 HEL2 BCL2 SLC8A1 ACTG1 EIF4G1 CACNA2D1 PRKAA1 GJA1 HDAC1 NCF1 PRKCB PRKCE FXR2 PRKCA HEL-S-102 MYL2 PRKD1 BMP2 ATF4 ELOC MOV10 PRKCZ PLCG1 JUN ARF4 NFKB1 TNFRSF25 NAPA TNFRSF10C SH3BGRL3 CLTC HGS SH2D2A AP2A1 NCF2 IQGAP1 ARRB2 FOXO4 AP2S1 SYNJ1 NCK1 EPN1 ADRB2 PLCB3 CREB1 RICTOR CSK S1PR1 ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 AGTR2 REN ACE2 AGTR1 CYP2R1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HEL-S-53e HAT1 HDAC2 HDAC10 DHFR ADH1A HDAC5 HDAC8 ADH1C HDAC9 HDAC7 HDAC6 ATF2 HEL-S-117 ALDH2 SLC19A1 ALDH1A3 MTR HDAC1 ACSS2 TYMS CYP2E1 MAT1A ALDH1A2 HDAC3 KAT2B SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 TRAF3 IF1AA9 TBK1 IFNAR2 TYK2 IFNAR1 IFNA8 MAVS RIGI IFNA2 ACE2 IKBKE IRF9 IFNA6 IFNA7 TICAM1 IFNB1 JAK1 IFNA1 IFIH1 IRF3 TLR3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 NFKB1 MAP1LC3A IFNG IFNB1 MYD88 TNF TRAF6 IRF3 TLR9 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 CD36 LAMB2 CXCL12 FOXC2 FOXC1 TCF2 VEGFA SHH KDR CTNNB1 PAX2 WT1 SIX1 CD2AP FGF8 NPHS1 NPHS2 NOTCH2 HEL-S-28 LMX1B LHX1 ROBO2 CXCR4 FGFR2 HOXD11 HOXA11 SLIT2 TCF21 GLI3 KIRREL1 ETV4 MAFB NCK2 EMX2 NCK1 FOXD1 EYA1 WNT4 GDNF RET INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 IF1AA9 IFNAR2 IFNW1 IFNGR1 PIK3CA IF1IB1 TYK2 IFNAR1 IFNA8 IFNK IFNA2 IFNL2 IFNL3 PIK3R1 IRF9 IFNA6 IFNL4 IL10RB IFNGR2 IFNLR1 IFNA7 IFNE PRKCA IFNB1 IFNG JAK1 IFNA1 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling GSK3B CREBBP NR2F6 STAT1 STAT3 CRP VAV1 SHC1 TYK2 SOCS3 IL6 NLK MAPK1 MAP2K4 MAPK3 BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2L1 PRDM1 HDAC1 RPS6KB1 MAP3K7 JUNB IRF1 IL6R VIP RAC1 JAK1 GRB2 NCOA1 TIMP1 SOS1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG INS PCSK2 PCSK1 GLP1R NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NKX2-1 FOXG1 TGIF1 NODAL TGIF2 GLI3 FGF8 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PLCB4 ITGB1 EGFR PAK1 FLT1 INSR CDH6 FGFR4 CDH2 NRAS DDB1 FOXM1 CDH16 IGF1R KDR PDGFRA CTNNB1 MYC KRAS MET FLT3 CTNNA1 FGFR2 ITGB3 ITGA2B PRKACG EPHA2 NTRK1 ITGA1 CDH9 KIT PAK6 CDH8 PRKAR1B DCAF1 PRKAR1A PAK4 CDH4 ITGA2 CDH10 CDH11 CCND1 CDH12 CDH15 AJUBA ITGA4 CDH17 VGLL4 CD44 ITGB7 CDH19 NF2 CDH24 NGFR WWTR1 PPP1R14A CUL4A LIN28B YAP1 CTGF PPP1CC HEL-S-80p RBX1 CSF1R NTRK2 ITGAM FGFR1 ITGB5 ITGB4 FLT4 ITGAE AMOT ITGB8 ITGAV ITGAX ITGB6 CDH18 LATS1 TEAD4 ITGA7 LATS2 ITGA6 HRAS TEAD2 TEAD3 FGFR3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G6 ACSL3 FADS1 ELOVL5 PLA2G4B FADS2 ACOX1 ACSL1 ACOX3 ELOVL2 FACL4 PLA2G5 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome TUBA2 STAT3 AMER3 STMN2 MZT2A FAM168B CCDC74A CDC27 CCDC42 ARHGEF4 POTEE GPR148 ARHA RAC1 APC PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 ITGB1 MYH9 LAMB2 HEL113 CDH2 MYO1E SCARB2 SMARCAL1 CD151 PTPRO SYNPO CTNNB1 CLDN1 PAX2 FYN WT1 CD2AP INF2 NPHS1 IRF6 NPHS2 HEL-S-28 LMX1B NOTCH1 CDKN1B HEL114 ITGB3 CD80 WNT1 CR1 PLAUR COL4A3 COL4A5 DAG1 LAMA5 TGFB1 PLCG1 CDKN1C COL4A4 TRPC6 MKI67 CTSL KIRREL3 DKK1 VTN KIRREL2 LRP5 TLN1 PARVA LRP6 FAT1 AGRN LIMS1 PLCE1 ACTN4 PCNA ITGB4 YWHAQ ITGAV NCK1 CDKN1A MME EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways LIF PDGFRA PTPN11 EGF FGFR2 SELENOP STAT3 ARAF ACVR1 SMAD1 ACTR2 ERAS ACVR2B PIK3R2 SMAD6 FZD1 WNT10B WNT10A FZD3 MDM2 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 PTEN JAK1 HRAS FGF23 EGFR SMAD4 FGFR4 PDGFA BRAF BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 AKT3 MAP2K3 MAPK1 MAPK12 MAP2K6 MAP2K1 MAP2K2 WNT5B IL6ST HNF1A RAF1 DVL1 DVL2 FGF8A DVL3 WNT1 WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD MAP2K5 AXIN1 JUN WNT16 MAPK7 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC FGF14 FZD4 SMAD9 FGF13 FGF18 FGF12 FGFR1 FGF2 WNT9B FGF7B FGF7A NOG FOS MAPK6 MAPK4 FGF5C GRB2 SOS1 FGFR3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CYP11A1 MAPK10 STAR HEL-S-2a CASP3 BAX HSD3B2 PARP2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A FHL2 GUCY1B1 MAPK1 FHL1 MAP2K1 MAP2K2 ADRB1 MYPN TTN RAF1 CSRP3 NUP62 ANKRD2 HEL-S-101 ANKRD23 C22orf13 MDM2 PRKACG TRIM55 TCAP NBR1 ADRB2 TRIM63 PRKCA PRKAR1A ANKRD1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 SOX17 FOXC2 FOXC1 TCF2 BMP4 GATA3 CTNNB1 SPRY1 PAX2 WT1 SOX11 LHX1 ROBO2 HOXD11 HOXA11 HOXC11 SLIT2 IFT27 GLI3 SALL1 IFT25 ROBO1 SIX2 GREM1 ALDH1A2 EYA1 GDNF FAT4 RET BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs ACACA PCCA PCCB ACACB PC MCCC1 BTD HLCS MCCC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety GCG LEP POMC GHRL MC4R AgRP NPY PYY ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis TLR4 MMP9 STAT1 SGCA SRC SOCS1 DMD MAPK1 TNF FYN MAPK3 HEL-S-28 BCL2L1 BCL2 EIF4G1 CXCR4 CD80 CASP6 RAC3 IL12B IL12A TICAM1 NFKB2 CD40LG IFNG PABPC1 CCND1 CYCS GSK3B DAG1 CASP9 NOD2 CASP3 TGFB1 HLA-DMA STAT3 BAX IL10 CASP2 DFFB DFFA IL2 IL6 TLR5 CCR5 CASP8 CD55 CCR3 PIK3R1 PARP1 AAG1 PS1TP5BP1 PYCARD CAAP1 SGCD EDN1 CXADR SGCB MYH6 SGCG AIF1 CHRAC1 CREB1 BNIP2 ABL2 MICA JAK1 SOS1 TLR3 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NLRP3 IKBKE CHUK RELA FCGR2A TBK1 IKBKG NFKB1 IFNB1 IKBKB IL1B REL GSDMD CGAS NLRX1 MITA F3 NFKBIA IRF3 NFKBIE LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G1B PLA2G4E SLCO2A1 PLA2G4C PLA2G3 PLA2G7 PLA2G10 PTGS2 ALOX5 PLA2G5 PLA2G6 CDKN1A HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYLK EGFR PAK1 ACTR3 DAAM1 MYL1 PFN4 PFN3 PFN2 CAMK1 SRC SHC1 CTNNB1 NEF3 MYC ERBB2 MAP2K4 MAPK1 NEFH ERBB4 NEFL GPX1 HEL-S-44 MAP2K1 TGFA RAF1 CDKN1B DVL1 PPP2CA PFN1 GSK3B MAPK8 AXIN1 FZD10 PLCG1 ROCK2 WNT16 JUN TMSB4X ARHA ACTR2 APC FZD4 FZD1 FZD3 CBL FZD2 FZD5 FZD7 FZD9 NCK1 FZD8 CDKN1A ACTA1 GRB2 SOS1 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 CALM1 STX1A PPP1R10 KCNQ3 PLCG2 AKAP5 P2RY1 CSNK2A1 SCN1B CHRM1 PRKCA BDKRB2 PPP3CC AGTR1 BACE1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A ADCY3 ADCY1 ADCY8 CNTF CAMK2G IL10RA BDNF LIF LTA SOCS3 GFAP GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 IL10RB IFNGR2 IL12B IL12A IL6R IFNG SLC1A4 CAMKK1 CAMKK2 TRAF5 TGFB1 STAT3 IL10 IFNGR1 IL13 PPP1CC ARC IL4 HEL-S-80p SLC2A3 SLC1A1 GRIN2B SLC6A9 GLS2 DLAT JAK1 TGFBR2 IL1A PLCB4 SMAD2 PLCB1 SMAD4 PLCB2 INSR STAT1 IGF1 PSAT1 TGFBR1 PSPH NELF GRIN1 SLC38A3 SLC38A5 DAO GRIK5 SLC1A2 GRIK3 IRS1 GRIK1 SLC7A10 MAPK1 TNF GRM2 GRM4 MAPK3 GRM8 PHGDH SRR LRRC8C IL6ST LRRC8D DISC1 LRRC8E BCL2 HEL-S-51e PRKCB PRKCA NFKB2 IL1R1 SLC38A1 GLS HEL-S-15 PIG59 GRIK2 TGFBR3 TNFRSF1A NFKB1 IL6 DLD CALM1 PDHA1 SLC1A3 SHMT1 FGF2 SLC17A6 SLC17A7 FOS IL13RA1 NGF PLCB3 TNFRSF1B CREB1 IL1B IL1R2 CAMK2D CAMK4 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 ADAMTSL2 EGF ZEB2 LTBP1 ZNF423 pp6425 BAMBI FBN1 LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency CCND2 CREBBP PPP2R3A EP300 PPP2R2C FOXD3 PPP2R2B POU5F1 WNT7B WNT7A CTNNB1 MYC CTBP2 MAP2K4 SOX2 WNT5B ZBTB33 LDLR PPP2R1B PPP2R1A LRRK2 PPP2R2A LEF1 CCND3 FBXW2 PAFAH1B1 PPM1J PRKCH NKD1 NKD2 PRKCB NFYA MAP3K7 ESRRB NR1C2 PRKCE PPP2R3B DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PPP2CA PRKD1 CCND1 GSK3B WNT2B CD44 MAPK10 PRKCZ MAPK9 AXIN1 FZD10 FRAT1 AXIN2 WNT16 JUN CSNK1E LRP5 NLK LRP6 ARHA APC CTBP1 FZD4 FOSL1 FZD1 WNT10B CTNND1 WNT10A FZD3 FZD2 PPP2R5E WNT9B FZD5 FZD7 FZD9 FZD8 PPP2R5C MMP7 PTPA SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway EMC7 MICOS13 OPA1 MFN2 APOOL MMGT1 IMMT EMC10 TMEM85 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 MFN1 EMC6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways SLC25A15 MDH2 ASL GOT2 NAGS SLC25A12 ASS1 GLUD1 ARG1 SLC25A13 LDHB FH OTC GLS2 GPT NOS2 HEL-S-32 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 ARHGEF1 ARHA 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation STX1A CREBBP NECAB3 APP SPEF1 SMC5 RELA SMC6 LYPD6 ENTREP2 UBN1 MLSN2 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J CXNO CGN CCL5 GOLGA8R GJD3 MTMR10 CANX KLF13 MYZAP OTUD7A TJP3 GOLGA8O CDC42BPB GOLGA8Q TRPM1 FANCD2 STXBP1 GOLGA8H CALM1 FAN1 CHRNA7 ANKRD2 GJA1 HDAC1 CXADR TJP1 SIN3A KAT2B STX1B IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta TF HAMP IREB2 TFRC HEPHL1 TFR2 SLC40A1 MCOLN1 SLC11A2 HEL60 STEAP3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 NR1C2 FFAR3 PYY FFAR2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 SGPL1 PEMT CHPT1 CEPT1 PISD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL OTC NAGS F7 GLS2 ASS1 GPT ARG1 F10 HEL-S-20 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling PIK3CD IL2RG RELA EP300 CHUK STAT1 STAT3 GAB2 CEBPA CEBPB PIK3CA SHC1 TYK2 NFKB1 IL4 SOCS3 SOCS1 IRS1 MAPK1 FLNA MAPK3 INPP5D BAD ATF2 PTPN11 MAPK11 MAPK14 NFKBIA PIK3R2 PTPN6 PIK3R1 FES SOCS5 CBL RPS6KB1 FOS IKBKB JAK1 STAT5B JAK3 GRB2 SOS1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CAP1 ELOVL5 IGF2R LPL CYP1B1 CEBPB PICALM SRSF9 TMED10 TMEM43 PHC2 TGFBR2 SRSF10 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling GSK3B ITGB1 SMAD2 WASL MAPKAP1 IGF1 IGF1R TNFRSF1A NFKB1 IRS1 RPTOR MTOR DEPTOR ACVR2B MLST8 HEL-S-28 EIF4E TNLG5A RPS6KB1 IGFBP5 PRKAB1 AKT1S1 MAP1LC3A TRIM63 PTEN EIF2B2 FBXO32 PPARGC1A RICTOR GDF8 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR STAT3 ROCK1 PLCG1 BDNF PIK3CA SHC1 NTRK2 GABRG2 ARHA PIK3R2 PIK3R1 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 CREM GABRE GABRQ GABRA2 GABRP SLC12A5 PIK3R3 GABRA6 PTEN GABRA5 GABRA4 GABRA3 CREB1 GABRG3 GABRG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PLCB4 POMC PLCB1 PLCB2 ARRB2 GPR143 PRKACG VEGFA PRKCB DCT GNA15 PLCB3 CREB1 ADCY9 PMEL ASIP GNAS TYRP1 TYR MC1R FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 APOB NR1C1 ACADM HADHB PPARGC1B STK11 ESRRA ACLY MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation GSK3B SPRED1 MAP1B MARK1 TAOK1 PHLDB2 MAPRE1 F2RL2 PAK1 STAT3 RHO ROCK1 SRC PARD6A CLASP1 NTRK2 LIMK1 APC CDC42 EPHB2 DVL1 AURKB NTRK1 PRKCA PTEN NTRK3 RAC1 CFL2 WNT3A CDC2 FREP1 TIAM1 MAPKAPK2 TRIO CAMK4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 RORC EBP AKR1D1 INSIG1 AKR1C4 CYP46A1 THEM5 DHCR7 HSD3B7 GPR183 ACOT8 LBP ACOT7 NR1H2 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 SULT2B1 CH25H AMACR ACOT6 SLC27A2 ACOT4 CYP3A4 DBP CYP7A1 NR3A2 EPHX2 CYP27A1 NR1i2 CYP8B1 SLC27A5 SULT2A1 IL25 ACOT9 IL17F IL17D IL17C IL17B IL17A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR SPHK2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation STX1A TDO2 TSC2 TPH2 ACHE TGFB1I1 TNF HRH3 NECTIN2 MAPK14 ADORA2A SLC5A7 ITGB3 SLC6A3 TNFRSF11B TH RBL2 UNC13B IL1R1 FBXO32 AMPH IL1B SLC6A1 SLC6A2 SYN1 DBH ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR SLIT2 RAC1 ROBO4 VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 ESD PON1 LIPA HEL126 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL1 LOXL2 LOX SMAD2 SMAD4 MAPK9 BMP1 MAPK8 TGFB1 GREM1 TGFBR1 BMPR1A BMPR2 MAPK14 TGFBR2 LOXL4 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GOT2 GAD2 AGXT ASPA ASS1 GAD1 GPT PC ABAT MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 PMVK MVD ACAT2 HMGCR FDPS SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 DLL3 MESP2 LFNG HES7 EPHA4 RIPPLY2 TBX6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 DHCR7 LBR HMGCR NR1H2 CH25H FDFT1 SQLE SOAT1 FADS2 SCD CYP27A1 FADS1 MYLIP ELOVL5 FASN ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK SREBF2 HMGCS1 SOAT2 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 FACL4 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP1 HDAC2 RBX1 STAT1 STAT3 HDAC3 DTX3L BTRC SKP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling SMO SUFU DHH PTCH2 SAP18 KIF7 SIN3A PTCH1 IHH GLI3 ADRBK1 SHH ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 IFNAR1 TNF ACE2 IFNA1 TNFRSF1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS5 PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN2A CCND2 SMAD4 BAK1 INSR NRAS MAP3K1 WNT7B WNT7A SHC1 CTNNB1 HMGB1 MYC AKT3 IRS1 ERBB2 MAPK1 SOS2 KRAS WNT5B BCL2L11 BCL2 LDLR CDKN1B BBC3 LEF1 TNFSF6 CCND3 RAC3 MAP3K7 RBL2 DVL1 PIK3R3 DVL2 TCF7L2 DVL3 TCF7L1 NFKB2 PMAIP1 WNT1 WNT3 MLKL WNT4 G6PC1 PCK2 WNT3A CCNG2 CCND1 GSK3B WNT2B PIK3CD MAPK10 MAPK9 MAPK8 TGFB1 TP73 BCL6 BAX AXIN1 FRAT1 WNT16 JUN PIK3CA NFKB1 ARHA BAD BIK PIK3R4 APC PIK3R2 PIK3R1 CDC42 PIK3R5 FOSL1 PIK3C2G FOXO3A WNT10B PIK3C2A WNT10A MDM2 PIK3C2B ATM PPP2R5E CDKN1A PTEN PPP2R5C RAC1 HRAS GRB2 SOS1 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing TLR4 MMP9 FST KLF4 TNC INHBA FGFR4 VEGFA SNAI2 HMGB1 HGF ACHE TNF CCL2 COL1A2 BCL2 EGF CHRNA7 CXCR4 FGFR2 FBN1 F13A1 PECAM1 FOXE1 HEXD DKFZp686P11128 DCN TIMP1 KRT6A KRT222 FLG IL15 PCTK1 SCEL HEL-S-43 COL1A1 AMBP SLURP1 MYD88 CASP3 LIN28A CD3E CXCL12 TPT1 BAX NFKB1 IL6 CXCL8 S100A6 IFNA2 BRD4 FGFR1 S100A9 NOX4 MMP28 ACTA1 IL8RB IFNB1 MMP2 IL1B CXCL1 FGFR3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p C7orf24 OPLAH GCLC HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 CDK7 RUVBL1 GTF2H2C_2 KARS1 CCNH GTF2H2 JUN GTF2H3 GTF2H5 SH3RF1 FOS NFKB1 HINT1 ERCC2 TCF4 RUVBL2 CTNNB1 MNAT1 NFATC2 USF2 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 AKR1C4 AKR1C2 CYP3A4 CYP1B1 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA ERI1 AGO2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 MAP4K1 MAP4K2 WWTR1 MINK1 YAP1 MAP4K3 RASSF1 LATS1 TEAD4 LATS2 STK38L TNIK TEAD2 TEAD3 HEL-S-31 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 MAPK8 TNFSF11 ITGB3 TRPV5 TNFRSF11B CTSK TNFRSF11A IFNAR1 IFNB1 SPP1 GPR68 AIMP2 ACP5 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB1 CACNB1 CDH2 SGCA CTNNB1 DMD CACNG1 CTNNA1 SLC8A1 CTNNA3 CTNNA2 ACTG1 tmp_locus_29 CACNA2D1 ITGB3 GJA1 LEF1 CACNA1C ITGA2B CACNA1F LMNA EMD TCF7L2 TCF7L1 ITGA1 CACNB3 CACNA1S ITGA2 ITGA4 DAG1 ITGB7 PKP2 JUP ACTN2 ACTN1 ACTN4 CACNA2D3 CACNA2D2 CACNA2D4 RYR2 CACNB4 ATP2A2 DSG2 DSC2 CACNG6 CACNG7 ITGB5 CACNG8 ITGB4 CACNG2 CACNG3 PS1TP5BP1 CACNG4 CACNG5 ITGB8 ITGAV ITGB6 SGCD SGCB SGCG ITGA7 ITGA6 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GSK3B PIK3CD TSC2 TSC1 NRAS UBE3A BDNF GRIN1 PIK3CA ARC NTRK2 DLG4 AKT3 PRKAA2 EIF4EBP1 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 PRKAA1 GRIN3B GRIN3A NF1 CACNA1C PRKAB2 SHANK3 RPS6KB1 RHEB PRKAB1 GRIN2B PIK3R3 SYNGAP1 PTEN HRAS HOMER1 CAMK4 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MEF2C ARAF NRAS BRAF GAB2 CRK MAP3K2 VAV1 SRC PIK3CA SHC1 AKT3 MAPK1 KRAS CRKL MAPK3 SHC4 INPP5D ATF2 SHC2 MAPK11 SHC3 MAPK14 BCR PIK3R1 BCL2 EIF4B HSPB2-C11orf52 BCLAF1 BCL9 RAF1 CBL RPS6KA1 SPAG1 PXN DOK1 HEL-S-102 HRAS GRB2 SOS1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 ANGPT2 PRKD3 PPP3R2 PRKCZ RCAN1 PRKCH PKN3 PKN2 PRKCB PKN1 NFATC1 PRKCE PRKCA PLCB3 PPP3CA PPP3CC PRKD2 PRKCI PRKCQ PRKD1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling IFITM3 CEBPB CCL8 RPTOR CCL4 LARP1 CCL1 DEPTOR MLST8 VPS11 EIF4E VPS16 CCL15 VPS18 GABARAPL2 VPS33A RPS6 RHEB AKT1S1 VPS41 HIF1A AHR LCK IF2B1 TF CD3G IL-21 CD3E CXCL12 IL18RAP PIAS1 IL10 IL13 IL4 IL5 RRAS CXCL8 APOC1 SMAD1 ULK1 SIGMAR1 IL9 HEL117 MMP25 IFIT1 GTSE1 VPS36 WDR74 CD226 TRPM2 APOH APOD RAC1 HEL103 JAK1 INTS4 HRG CXCL13 CTSZ TGFBR2 SERPINA10 SDF2 CCR6 IL1A TOMM70 GP1BA IL16 HMFT1766 IFI6 OS9 PTGS2 MIB1 STAT1 SRP19 HEL-S-81p HP IFI44L CLCC1 TLE3 GTF2F2 UGCGL2 G3BP2 CXCL6 NLRP1 DKFZp781O1323 NPTX1 MDN1 IFITM1 FAM83A CXCL3 NEK9 IL7 CD163 TP53I3 LGALS3BP TNF TRO TRIM59 BST2 ITIH3 ATE1 IFI27 MX1 CCL20 TBKBP1 ATP13A3 IL33 FAM98A CCL22 CCL21 HBB CCL27 PF4 CCL26 DDIT4 RTN4 FGA HEL-S-78p NFKB2 ALB SAA1 SAA2 IRAK1 CASP9 MYD88 CASP3 TRAF2 TRAF6 SRP54 HBD CXCL5 MTOR TPO FGF2 PMPCB IFNB1 ADAM9 IL1R2 CXCL9 PITRM1 CXCL1 CCL3 NLRP3 HEL-S-130P CXCL2 CRP RRM2 GGH CCL11 ZAP70 CARD11 CCL5 EIF4EBP1 HLA-DRA NFATC3 FYN CCL2 APOA2 PTPN6 OAS2 IRF9 C8A IL12A C1QBP CCNB2 IFNG CCNB1 CDC2 IL17A HLA-DRB5 NRF CD8B1 MAPK8 PRG3 CD2 CFH IGLL1 CD8A CFI LBP CFP CTSL CPN1 CASP8 PARP2 C1R SELP HEL-S-72p EGR1 IFIH1 IRF3 CD14 BIRC5 ITIH4 TRAF3 HLA-DRB1 APOL1 ACE2 CASP5 COQ8B ACTG1 TNFSF10 STEAP3 JUNB NTRK1 PRKCQ MOV10 DKFZp762B153 TBK1 IKBKG JUN IL6 CCR5 MAVS RIGI EIF4A2 PS1TP5BP1 CXCL16 FOS IL8RB IL18 IL1B CXCR1 ITCH CAMK4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling GSK3B RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 CEBPD CTNNB1 SPP1 APC CSNK1A1L TOR1AIP1 SLC2A4 CDK6 PPARG WNT10B LEF1 ZMPSTE24 FNTA LMNA HES1 EMD HES5 TCF7L2 TCF7L1 ICMT HMGA2 DICER1 TARBP2 CCND1 AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 SMARCC1 SMARCA4 MBD5 NCOA6 SMARCD2 ARID1A PAXIP1 SMARCC2 SMARCD3 KMT2C ACTL6B DPY30 ARID1B PAGR1 ASXL1 WDR5 BAP1 ACTL6A EHMT1 ASH2L H3F3B RXRA NR1I3 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways OSTM1 PLEKHM1 NFKB1 SNX10 TNFSF11 IKBKB TCIRG1 TRAF6 RAB7A TNFRSF11A CLCN7 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 CYP24A1 AGTR2 REN KLKB1 ROCK1 NFKB1 CPN1 KLNA1 BDKRB2 CYP3A4 PRKG1 IL1B MAPK1 NR1i1 TNF ARHA BDKRB1 ACE2 AGTR1 IL1A SERPING1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome USP9X PDE6D BBIP1 DYNC2I2 INVS NPHP3 DYNC2H1 CRX DYNLT2B TRAF3IP1 SUFU CEP164 FLCN DYNC2LI1 IFT52 KIF7 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 OCRL CEP290 SCAPER ZIC2 BBS4 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK IFT172 TMEM216 EFHC1 WDPCP EFHC2 IFT74 CNGB1 SDCCAG8 PKD1 CEP104 ARL6 ARL3 PKD1L1 PKHD1 PTCH1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 PCARE SMO SCLT1 DCDC2 IFT81 FUZ TTC8 GPR161 MKS1 CEP41 IFT27 TRIM32 GLI3 CLUAP1 RAB23 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1A2 NAA50 CYP2J2 GATF-C CYP21A2 GLYATL2 AKR1D1 CYP4F11 AKR1C4 CYP46A1 CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 LOC51064 CYP7B1 SULT2B1 HS2ST1 SULT1C3 CYP26B1 CYP4V2 HYAL3 CYP2C19 UGT2A2 CYP3A7 UGT2A1 CYP3A4 GAL3ST2 CYP2W1 GAL3ST3 SULT1C4 CHST8 HS3ST3B1 CHST9 EPHX2 CHST6 CHST7 CYP2R1 CYP3A43 KCNAB1 KCNAB3 CYP2A7 CYP26C1 CHST1 CHST4 CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 CYP17A1 CYP2A13 UGT1A5 AKR1B1 CYP2F1 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 GSTZ1 CYP20A1 CYP4F2 CYP4F12 HEL-S-165mP EPHX1 CYP7A1 CYP11A1 MGST1 GSTT2 UGT1A3 SULT2A1 CYP1A2 CYP1B1 MGST3 GPX3 MGST2 CYP1A1 CYP2E1 GSTM3 NNMT TPMT INMT GSTM5 CYP4F8 CYP2C8 UGT2B4 UGT2B7 NAT2 CYP2S1 GSTM1 SULT1A1 SULT1E1 BAAT CYP27B1 SULT1C2 CYP11B2 HEL-75 CYP27A1 GSTM2 CYP8B1 GSTA5 CYP2C9 GSTA4 CYP2A6 GSTA3 UGT1A10 CYP2B6 UGT1A1 UGT1A9 HEL-S-64p HS3ST2 GSTM4 GPX4 CYP51A1 CYP24A1 GPX2 HEL-S-22 UGT1A4 UGT1A7 AKR1C1 AKR1C2 HEL-S-75 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 HEL-S-21 HEL-S-166mP UGT2B11 GAL3ST4 UGT2B15 UGT2B17 CYP2U1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP2C18 CHST13 CHST14 NAT8L GSTT2B SULT1A4 CYP4F3 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CDKN2A EGFR MAPK8 BAK1 BAX TRAF2 TRAF6 JUN TNFRSF1A FAS PDGFRA IL2 IL6 MAP2K3 HBEGF MAP2K4 TNF MAPK12 BMF MAP2K6 MAPK13 MAP3K5 ATF2 FGF7 MAPK11 MAPK14 BCL2L11 BCL2L1 BCL2 NFE2L2 TNFSF10 TNFSF6 CCNE1 JUNB FOS CCNA2 CDKN1A IFNG RB1 MMP2 MCL1 CCND1 TRAF5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 ATG3 TSC2 INSR TSC1 ATG12 ATG16L1 INS ATG14 MAP1LC3A ATG5 AMBRA1 SH3GLB1 CHAF1A UVRAG ATG9B ATG10 ULK2 VMP1 ULK1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 GCK ACSS1 MTTP LMF1 LDLR PLTP GPIHBP1 LPL FAS PDIA2 APOA5 APOC2 LIPC GCKR DGAT2 APOA2 SEL1L COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SGOL1 PTTG1 ESCO1 ESCO2 REC8 SMC1B MAU2 STAG2 SMC3 STAG3 ESPL1 WAPAL HDAC8 APC PLK1 PDS5B PDS5A PPP2R1B RAD21 PPP2R1A PPP2R5E SMC1A PPP2R5B PPP2R5A AURKB PPP2R5D PPP2R5C PTPA PPP2CA CDC2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation PDLIM7 SLC34A1 FGFR4 PFN3 IGF1R CAPN3 SRC GRIN1 MYC KDM6B HEL-S-273 COX2 GPRIN1 ARL10 H2AX CXCR4 ADAM10 PTH FGF8A TMED10 HK3 NTN1 COX1 MAPK10 MAPK9 MAPK8 GNAI1 RNP24 PLCG1 PRR7 EIF4E1B GNAI3 JUN COX7B KIAA1191 COX4I1 FAF2 MAX CLTB DDX41 TRIAP1 COX6A1 BABAM1 BABAM2 BARD1 UIMC1 COX8A EED INPP5D TMED9 RNF44 CYP7A1 UNC5A MYO7B PNPLA2 COX6B1 PIK3R1 ARFGAP2 FBXW7 HIC2 DOK3 CDHR2 FAM193B DBN1 ABRAXAS1 USH1C BRCC3 COX7A1 LMAN2 MAGED1 RAB24 COX7C COX3 ZNF346 SNCB PRELID1 PTPRN2 NELFB NOP16 GRIN2B MUPCDH COX5A HIGD2A TSPAN17 BRCA1 DRD2 SNCA ANKS4B H3F3B MXD3 FRS2 ABHD5 GRB2 SOS1 RGS14 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis DHRS7B AGMO AGPS LPIN1 LPIN2 LPIN3 CEPT1 FAR1 UGT8 PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L PEX3 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation MIXL1 ITGB1 KLF4 CNP HOMER3 MBP FOXD3 MSX2 PAX3 MOG S100B OLIG2 SOX10 GFAP ACHE TWIST1 GATA4 NEFL MSX1 LHX1 GAD2 NR2A1 TPM1 GAD1 GATA6 MAP2 TWIST2 DLG4 CLDN11 ERAS CASK CACNG2 ROBO1 SHANK3 GRIN2B SLC6A5 SLC6A9 DLG2 SHANK1 SLC6A1 SLC6A2 HOMER1 TNC AQP4 RIMS2 BSN CDH2 RBFOX3 FBXO15 TBR1 SNAI1 ZFP42 SNAI2 LIN7A BMP4 FUT4 POU5F1 TPH1 ChAT HOMER2 GRIN1 FEV CD24 NEF3 PCLO ERC1 SLC1A2 CD34 PAX6 ADRA2C ADRA2B ADRA2A DPPA3 DPPA2 SOX2 DCX TBXT GLRA1 GLRA2 LMX1B GLRA3 NOTCH1 GABBR1 HTR5A GLRB RIMBP2 NLGN1 5HT1A CSPG4 FOXA2 SLC6A3 LEF1 HES1 ESRRB HES5 PECAM1 GLS NGFR SOX17 PIG59 GPHN GABBR2 KCNJ6 SNAP25 SOX9 SLC1A3 NODAL AP2A1 AP2A2 TH SLC17A6 SLC17A7 FGF7A SLC18A3 HES3 UNC13A ITGA6 SYP CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 ADCY1 MAPK9 MAPK8 DAGLA CYP2C19 CYP3A4 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 ADORA2A FAAH CYP2C9 CNR2 NAPEPLD DAGLB PRKACG CYP1A1 PRKAR1B CNR1 PRKAR1A AHR TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R5 PIK3CD EGFR RAF1 PIK3C2G PIK3C2A PIK3C2B NRAS PIK3CA PIK3R3 AKT3 ERBB2 MAPK1 ERBB4 KRAS MAPK3 HRAS PIK3R4 PIK3R2 PIK3R1 ERBB3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IF2B1 IL15 RORC RORA ID2 TBX21 IL13 GATA3 TOX IL4 IL6 IL5 IL7 TNF IL33 ZBTB16 HNF1A TSLP IL9 IL25 GFI1 ATL1 NFIL3 IL12B IL12A IL18 IFNG IL23A IL1B AHR IL17A AREG MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TAOK1 CACNB1 LAMTOR3 RRAS2 CACNG1 SOS2 EGF FGFR2 PRKACG PLA2G4B ARAF CDC25B NFATC1 MAX RASGRP3 RAP1A RRAS DDIT3 CRKL GADD45A CACNA2D3 CACNA2D2 PPP3R1 CACNA2D4 PPP3R2 CACNB4 CACNG6 CACNG7 CACNG8 NF1 CACNG2 CACNG3 CACNG4 CACNG5 MAP3K13 IKBKB PPP3CA RAC1 PPP3CC HRAS TGFBR2 IL1A EGFR NTF4 PAK1 RELA FGFR4 NRAS MAP3K1 MAP3K7IP1 FAS FGF10 RPS6KA3 MAP2K3 MAP2K4 TNF MAPK12 MAP2K6 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K11 SMIM40 RAF1 TNFSF6 CACNA1C CACNA1F FGF8A NFKB2 IL1R1 CACNA1S FGF6B MAPKAPK2 MAP2K5 CASP3 CHUK TRAF2 TRAF6 CRK TNFRSF1A MAPK7 NTRK2 NLK FGF20 FGF22 FGF7 FGF21 FGF8 DUSP4 FGF9 FGF16 FGF14 FLNB CDC42 FGF13 TAOK2 FGF18 FGF12 FGFR1 FGF2 FGF7B FGF7A DUSP2 NGF FGF5C IL1R2 GRB2 SOS1 FGFR3 MEF2C BDNF FLNA NFATC3 STK4 RPS6KA4 RPS6KA5 RAC3 MAP3K8 MAP3K6 MAP3K7 MAP3K12 HEL-S-31 MAPK10 MAP4K1 MAPK9 MAP4K2 MAPK8 TGFB1 MAP4K3 MAP3K2 HEL-S-103 HEL-S-72p RASGRF1 MAPKAPK5 HSPA2 PLA2G4F CD14 FGF23 PLA2G4D PLA2G4E PLA2G4C PDGFA BRAF TGFBR1 MYC AKT3 JUND MAPK1 DUSP10 KRAS MAPK3 ATF2 CACNA2D1 LRRK2 MAPK8IP3 MAPK8IP1 ECSIT DUSP3 DUSP8 DUSP9 DUSP7 PRKCA RAPGEF2 NTRK1 NTF3 TAOK3 CACNB3 RASGRP4 CACNA1H CACNA1G CACNA1I HEL-S-102 RASGRF2 DUSP16 PPM1B RASA2 pk ATF4 PPP5C MAPK8IP2 RELB IKBKG JUN GNG12 MAPKAPK3 NFKB1 MAP3K14 CACNA1B CACNA1A ARRB2 FOS IL1B PTPN5 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABBR2 GABRG2 SLC6A11 GABBR1 GAD2 AP2A1 GAD1 AP2A2 GABRB3 GABRB2 ABAT AP2S1 GABRB1 GABRE GABRQ GABRA2 GABRP AP2M1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 SLC6A1 GABRG1 SLC32A1 ALDH9A1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HEL25 CBX3 MBD2 CBX1 CHD4 HDAC2 CHD3 MTA2 H3C8 RBBP7 MTA3 MBD3 HDAC1 LEF1 SUV39H1 KDM1A H3C15 RB1 H3F3B RBBP4 KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome TMEM98 GNRH1 NEUROG1 FGFR1 SEMA3E ASCL1 OTX2 ANOS1 PIK3CA PLXND1 OLIG2 PROK2 SOX10 MYRF FRS2 MAPK1 LHB PTPN11 FGF8 GRB2 MAP2K2 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma DKFZp762B153 NFE2L2 STAT3 TFEB MDM2 IPO8 PINK1 AGER PARK2 NFKB1 HMGB1 SQSTM1 KRAS VMP1 SHOC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP2C8 FADS1 ELOVL5 ALOX12 LTC4S PTGS2 CYP2C9 HEL-S-22 ALOX5 ALOX15B CYP1A2 ALOX15 HPGD GPR32 FPR2 CYP2E1 PTGS1 PTGIS CYP3A4 GSTM4 FADS2 EPHX2 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 RPS6KA5 BRAF HTR4 HTR6 HTR7 RAP1A CREB1 MAPK1 EGR1 MAPK3 ATF1 GNAS MAP2K1 MAP2K2 MAPKAPK2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome AFDN F11R GJA3 GJA5 ACP6 CTNNB1 GJA8 AMELX NBPF12 CHD1L PRKAA2 PYGO2 TJP3 PRKAG1 PRKAG2 PYGO1 BCL9 PRKAG3 PRKAA1 GJA1 KIRREL1 PRKAB2 PRKAB1 FMO5 TJP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex HIST1H2BE HAT1 ASF1A CREBBP ASF1B HDAC2 EP300 MBD3 EP400 MAPK3 H2BC21 H2AX HDAC1 TLK2 RBBP4 KAT2B MBD2 CHD4 CHD3 MTA2 H3C8 H3C15 PWWP2B UBTF PWWP2A TBP SIRT7 POLR1A POLR1C POLR1D RRN3 SRCAP TAF1D H2AC19 TAF1B H2AB1 TAF12 H2AC14 GATAD2B H2BC26 GATAD2A H2BC12L CDK2AP1 HIST1H2AB H2BC9 KAT2A H2AZ1 H2AZ2 H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 H2BC1 H2BC17 H3F3B H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2AC20 H2BC11 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PLA2G1B PTDSS2 PTDSS1 CHKB PCYT2 ETNK1 GPAM PEMT CDS1 CHPT1 CRLS1 PISD AGPAT4 GPAT4 PNPLA3 DGKZ DGAT1 DGAT2 CDIPT PNPLA2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP EPHX1 CYP3A4 CYP1A2 GSTM1 CYP2A13 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle MCM5 MCM6 TTK CDKN2A CCND2 FZR1 HDAC2 CDC45 WEE2 EP300 CDKN1B CCND3 E2F2 ANAPC1 SMC1A CCNA2 CCNE2 CCNB3 CCNB2 RB1 CCNB1 GADD45B CDC2 GADD45G CCND1 CHEK2 CHEK1 PTTG1 TGFB1 SMC1B CDC25B STAG2 CCNH SMC3 CDC27 ESPL1 E2F4 GADD45A PLK1 TFDP2 MCM2 RAD21 CDK7 MAD2L2 STAG1 MDM2 CCNE1 ATM ATR CDC20 SMAD2 SMAD4 WEE1 CDK4 MYC CDK2 HEL2 HDAC1 RBL2 RBL1 TFDP1 CDKN2D CDKN2B E2F5 CDKN2C GSK3B SFN CDKN1C SKP1 RBX1 PRKDC PCNA CDK6 E2F3 YWHAQ HEL-S-1 CDC14B YWHAG CDC23 PTTG2 SKP2 ANAPC7 ANAPC5 YWHAZ MAD1L1 ANAPC2 CDKN1A ANAPC13 PKMYT1 ANAPC11 ORC6 ORC3 ORC2 CDC6 MCM7 ORC1L DBF4 MCM3 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23 HEL-S-310 RPS6KA2 RPL4 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPS15 FAU RPS14 RPL13A RPL7A RPS6KA3 RPS17 RPS16 RPS18 RPL36 RPL35 RPL38 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPS6KB2 RPL5 RPL22 RPS3A RPL30 RPL7 RPSA RPS6KA6 RPL18A RPS6 RPL37A RPL29 RPL28 RPL10 RPL12 RPS11 MRPL19 RPS6KB1 RPL36A RPS4Y1 RPS15A RPL14 RPS19 RPS3 RPS27A RPL13 RPS2 RPL11 RPL15 RPL18 RPL17 RPL19 RPL27 RPL41 RPL35A RPL26 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP2 RPL10A RPS6KA1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation HDAC10 FHL2 LDB2 PAX3 SOCS2 DMD HDAC6 FYN CCL2 CDON PRKAG2 ZBTB16 LHX1 CTNNA2 FGFR2 MAFB POU2F2 ELOVL4 GATA6 NR1C2 TCF3 NUMA1 CDH8 SDCBP GAS2L1 KRT6A RGMA NF2 CTNND2 ARHGDIG KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E ARX STC1 NFATC1 ARHGAP15 ZBTB2 JUP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B TFAP2C SMURF1 GREB1 NR2F2 CLDN11 PAN2 PTPRB PPFIBP2 SCHIP1 HMGB2 WDR44 SIX6 AHI-1 BOC RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 FZD5 ARHGEF9 BMPR1A KIFC3 RUTBC3 STX16 FZD8 RRBP1 TBL1X CLVS1 TTC14 TNLG7C SNCA C1GALT1 TRPM2 VAX2 RIT1 GLB1 ZNF219 BCOR SKIL MYORG ELOVL2 SMAD4 CDH6 OGT BMP4 SHH CTNNB1 MYC PAX6 TFAP2A SOX2 CAP2 PDE7A NLGN1 FOXA2 TNFRSF11B TCF7L1 WNT1 SPRY2 CELSR2 NLK UBTF ZFHX4 PTPN13 PIM1 CTBP1 FZD4 MKS1 GLI3 H2BC9 TOX3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway GALNT9 MAMDC2 ATP1B2 MID1 ERAF CRTC2 SPINT1 PAK1 C1QTNF12 EPOR EP300 FAM20C RELA SPIRE1 ARHGEF7 SFI1 IFI44L ATP10D TSPAN33 RHD CAMK1 ENHO CYB5R3 TSPAN8 SLC25A21 NLRP1 KDR FIS1 STIM1 SLC38A5 WFS1 KLF1 LR8 SLCO3A1 CCL5 TRPV4 CPOX MAPK1 RHAG TNF MAPK3 NFATC2 HFE RPTOR TBXT SLC2A4 ACACA RAF1 FASN NFE2L2 RPS6 SIRT1 ABCA1 RPS6KB1 SMC1A MAP1LC3A SQSTM1 HIF1A CAMKK2 PCK2 CCND1 MX2 KEAP1 VCAM1 GCK IL15 HMBS DKFZp762B153 CHRM3 TSC1 WDR35 DGIC HMOX1 PFKFB2 HK2 ULK1 MTOR CALM1 SELL PARP1 ASNS CCNE1 S100A8 AQP1 CREB1 RAC1 MAF MS4A3 CXCL11 IFGGE OASL ERMAP CAMK4 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CHRNB4 CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA EGFR PTEN RPL11 AKT3 FOXO3A MAPKAP1 RICTOR RIOK2 RIOK1 MTOR MLST8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 MAVS RIGI IFIH1 MR1 IRF3 TLR8 TLR7 TNFRSF11A TLR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion GNA11 PLCH1 PLCD3 PLCB1 PLCB2 PLCB3 PKD1 PLCG2 PLCG1 PLCL1 PLCE1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 ARID5B TBX1 UCP1 PRDM16 PPARGC1A IRX5 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC RBX1 CBFB CUL5 UBB RUNX1 APOBEC3G NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B3GNT5 NEU2 FUT5 B4GALT1 FUCA1 FUT1 NAGA FUT2 SIAT4C B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NFE2L2 TGFB1 NQO1 SIRT1 CDC37 EXOC6 ECSIT DDR1 SUV39H1 NRF1 HEL-S-7 PKD1 COL2A1 FGF7 BMP2 IGFBP7 LOXL4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC1A RAD21 RAD18 PAXIP1 BRCA1 MRE11A MDC1 ATM SMC3 NBN RAD50 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELE TLR4 SELP TGFB1 SELPLG PF4 CD40 CD40LG CCL5 IL1B CCL2 TLR7 VCAM1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism CD36 STAR PBR LIPC LIPA APOA2 CYP27A1 PCSK9 APOA4 SCARB1 MTTP APOB LDLR MYLIP PLTP ACAT2 LPL HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK LIPG MVD NPC1 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 CIDEB FABP2 VAPA EBP CYP51A1 SC5D DHCR24 DHCR7 LBR LPA HMGCR FDFT1 DGAT1 SORT1 SQLE APOC2 SOAT1 APOC3 ABCG8 APOC1 ABCG5 CYP7A1 APOE ABCB11 APOH STARD3 NPC1L1 NPC2 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DROSHA MRE11A ATM NBN RAD50 DDX1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 NFE2L2 SLC3A2 SLC7A5 KEAP1 ATF4 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling HHIP SPOP CSNK1G3 CCND2 SMURF2 FBXL17 SPOPL CSNK1D GAS1 CSNK1G2 CSNK1G1 EVC ADRBK1 CSNK1A1 SHH CSNK1E DHH IHH SMURF1 PTCH1 CDON EVC2 CSNK1A1L BCL2 SMO BOC ARRB2 GPR161 GLI3 PRKACG SUFU PTCH2 KIF3A KIF7 CCND1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL5 ACE2 FADS2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PHGDH PSAT1 PSPH ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling RELA STAT1 CEBPB VEGFA SRC TYK2 SHC1 SOCS3 IRS1 CDK2 MAPK1 JUND KRAS MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 IL6ST RAF1 CDKN1B RPS6 PRKCH PRKCB PXN JUNB PRKCE PRKCA OSMR HIF1A STAT5B PTK2B JAK3 OSM MAPK9 MAPK8 CASP3 STAT3 NFKB1 MTOR PIK3R1 FOS CREB1 JAK1 RICTOR EGR1 HRAS GRB2 SOS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 MAPK1 RYR3 ITGB3 MFAP5 MAPK3 TNNC1 PRKCQ PLCG1 JUN ITGAV GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis NOTCH1 MESP2 LFNG HES7 EPHA4 RIPPLY2 WNT3A FGF8 TBX6 HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC1H1 DCTN1 ADCY3 RAB11B DYNC1LI2 DNCL1 ADCY6 AQP4 ARHGDIG DCTN6 DCTN5 DYNC1I1 RAB5B DCTN4 HEL-S-47e HEL-S-77 AQP2 AQP3 ARHGDIB AVPR2 DYNC1LI1 RAB11A GNAS RAB5A DYNC2H1 CREB3L3 AVP CREB3L4 PRKACG DYNLL2 CREB3L2 CREB3 RAB5C DYNC2LI1 CREB1 ADCY9 STX4A CREB5 VAMP2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling BCL2 MAPK9 CHUK GNGT1 BRAF IKBKG JUN PIK3CA FOS NFKB1 SP1 GPER IKBKB CREB1 MAPK1 GNB1 GNAS MAP2K1 MAPK14 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle INS SLC2A4 HEL-S-68p PGAM1 HEL-S-133P PFKP GPT HEL-S-49 HEL-S-87p HEL-S-162eP SLC2A2 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK1 TLR4 IRAK4 MYD88 TRAF6 AGER NFKB1 TREM1 IL6 IFNB1 CXCL8 IL1B MAPK1 TNF HEL110 IFNA1 CD14 IL1A TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 SMAD4 WWTR1 SPARC TGFBR3 POSTN CTGF TGFBR2 TGFBR1 YWHAG RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling AFDN GNG3 GNG2 GNG5 GNG4 GAB2 GNG7 GNG8 ZAP70 KDR SHC1 KSR1 PDGFRA RRAS2 PLA2G2A SOS2 MET SHC4 LAT SHC2 PTPN11 SHC3 STK4 FLT3 FGFR2 PRKACG RAC3 PLA2G5 PLA2G6 PIK3R3 RAB5C PLA2G4B PAK6 PAK4 MAPK10 MAPK9 MAPK8 CALML6 CALML3 ARF6 CALML4 EXOC2 HTR7 RASGRP3 RAP1A RRAS PIK3R2 PIK3R1 RASGRF1 NF1 GRIN2B SYNGAP1 IKBKB ABL2 RAC1 HRAS KSR2 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D RALA PLA2G1B PLA2G4E PLA2G4C PLA2G3 EGFR PLA2G10 PAK1 FLT1 INSR RELA FGFR4 NRAS IGF1R GRIN1 RASSF1 AKT3 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAB5A BCL2L1 ETS2 RAF1 TNFSF6 EPHA2 PRKCB GNG10 GNGT2 PRKCA NTRK1 RASGRP4 KIT REL RASGRF2 TIAM1 RASA2 PIK3CD NGFR CHUK PLCG2 PLCG1 IKBKG RAB5B GNG12 GNG11 PIK3CA NFKB1 GNG13 CSF1R NTRK2 GNB2 ARHA GNB1 BAD PLA1A GNB4 RASAL1 GNB3 RASAL3 PLCE1 TTBK1 GNB5 RASA4B RALBP1 CALM1 PLAAT3 CDC42 RASA3 RASA4 RIN1 RAPGEF5 PLA2G2F PLA2G2E FGFR1 PLA2G2C FOXO4 PLD2 GNGT1 FLT4 RALB GRB2 SHOC2 SOS1 FGFR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CHST7 EXT1 CHST1 CHPF CHST3 XYLT2 XYLT1 EXTL2 HS6ST1 EXTL1 HS6ST2 CHSY1 HS6ST3 CHSY3 CSGALNACT1 NDST3 CHPF2 B3GAT3 GLCE B3GAT2 B3GAT1 CSGALNACT2 B3GALT6 HS3ST1 HS3ST3A1 EXT2 UST CHST11 CHST12 HS3ST2 CHST13 CHST14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 SMAD2 CASP9 CASP3 STAT1 BAX MRE11A CDC25B MSH6 RAD50 MSH2 BLM CDK4 MYC CDK2 CASP8 BARD1 ATF1 MAP3K5 BAD PLK1 BCL2 CDKN1B BBC3 NOXA1 MDM2 ATM ATR POU2F1 BACH1 CDKN1A PTEN BRCA1 RB1 JAK1 CDKN2B CDC2 CHEK2 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell SPRYD4 AP3D1 PHLDB2 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 LAMTOR3 LAMTOR5 TUSC2 LTN1 CPOX ARID4B CALCOCO2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ERBB3 POGLUT3 VPS39 KPNA3 EIF4E AXL MYLIP TPM3 TPM1 GRIA2 STX7 UBE4A ATG9A CDKAL1 RAB30 GPD2 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP MCL1 CCND1 CD164 BRPF3 HMGA1 SLC4A10 NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 CHMP2A SRPRB DKFZp761E1322 PICALM SLC25A1 DOCK5 TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 HSDL1 DSG2 ARID1A TXN2 RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 NXN UHRF1 HSD17B12 GNA13 DNAJB1 CAND1 PPP3CA POLR2C TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 CSF1 IRS1 MAPK12 MAPK14 PPIF MTRR LPL RTN4 KIT PRKCI COL3A1 DOCK7 RARS1 HEL-S-47e MAPK7 CDK6 E2F3 ITGB4 LAMC2 FGF2 P4HA2 NELFCD CDKN1A TMEM87A VSNL1 FSTL1 CA12 CAMTA1 ACVR1B PPIB HYAL3 ERBB2 CDKN1B LAMC1 C1QBP TNFRSF10B ITGA2 CCNG1 SNAP23 PTPRF COL1A1 SPARC SYPL1 THBS1 GPAM CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 GFPT1 ERG ATP6V0E1 CPNE8 VEZT TMEM41B EHMT1 SLC38A5 CLDN1 PWP1 ABCG2 KRAS CHORDC1 RAVER2 COL1A2 CIAO2A SEC62 NOTCH2 CDK5RAP3 NOTCH1 BCL2 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B GJA1 FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 HES1 HACD3 MRPL20 SLC7A11 BACH1 COMMD9 RDH10 GRPEL2 SNX6 SLC38A1 GSTM4 RAB27B MOV10 POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B RNP24 NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MRC2 PANX1 COIL SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC MRPS24 ATP2A2 ELMOD2 TMT1A AP3B1 SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN SSNA1 AMIGO2 NAPG HEL-S-66 PTPA NT5E PGRMC1 PPP1R7 USP1 SHOC2 SRSF10 MPZL1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS IL12A VIP IL2 IL4 IL5 IFNG TGFB1 CD80 IL10 CTLA4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 POMC CDKN1B PPARG YAP1 CRP VEGFA CDKN1C INS FOS CDKN1A IL6 CREB1 BCL2L11 VAMP2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 EGFR RAF1 SMAD4 TGFB1 TGFBR3 AXIN1 NRAS TGFBR1 TSPAN8 CTNNB1 HGF MFGE8 DKK4 ERBB2 KRAS MET WNT3A HRAS MTOR TGFBR2 TGFA APC CD133 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion MYL11 MYL5 MYLK MYL7 ITGB1 LAMB3 CCND2 TLN2 TXK LAMB2 MYL12A MYL12B MYL10 VASP SRMS CAV3 TNK1 PARVB VAV1 PARVG VAV2 ARHGAP5 DOCK1 SRC STYK1 KDR SHC1 c-fgr PDGFRA ZYX PDPK1 HGF ERBB2 FLNA MET FYN SHC4 SHC2 SHC3 PDGFC HEL-S-28 EGF ITGB3 ITGA2B CCND3 RAC3 LAMC1 PXN IBSP PIK3R3 ITGA1 PAK6 PAK4 PIP5K1C ITGA2 COMP BLK CCND1 ITGA4 MAPK10 COL1A1 ITGB7 LAMA5 MAPK9 MAPK8 PPP1CC THBS1 PPP1R12B HEL-S-80p VTN RAP1A PPP1R12C TLN1 PARVA CRKL SPP1 ACTN1 ACTN4 PIK3R2 PIK3R1 LAMB1 RAPGEF1 RASGRF1 PTEN RAC1 HRAS EGFR PAK1 TNC FLT1 PDGFA BRAF IGF1 VEGFA IGF1R CTNNB1 EMP2 AKT3 MAPK1 MAPK3 COL1A2 MYLK2 MAP2K1 PDGFD BCL2 RAF1 ACTG1 HEL114 PRKCB PRKCA COL2A1 ARHGAP35 MYL2 RELN VEGFB VEGFC GSK3B VEGFD XB PIK3CD TNR CRK COL4A2 BIRC2 ROCK1 COL4A1 BIRC3 ROCK2 JUN COL4A4 COL4A6 PIK3CA CAV2 CHAD ARHA BAD CDC42 FLNB COL5A3 COL5A2 ITGB5 ITGB4 TNK2 LAMC2 PS1TP5BP1 PTK6 ITGB8 ITGAV ITGB6 VAV3 VWF ITGA7 ITGA6 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 MYLK3 SOS1 THBS3 MYLK4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation AP3D1 TM6SF1 HTT SPCS3 HOMER2 AGAP2 RAMAC ZNF592 PDE8A RNMT WDR73 BNC1 BTBD1 GOLGA6L4 ADAMTSL3 SH3GL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB DNM3 RYR1 NMBR RYR2 EGF AP3B2 SPCS2 RAF1 SPCS1 ALPK3 ZSCAN2 SYNJ1 SHANK3 SHANK1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 CYP11A1 HSD11B2 SRD5A2 POR CYP21A2 STAR H6PD HSD3B1 HSD17B3 CYP17A1 CYP11B2 HSD3B2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair TDG POLE4 SMUG1 HMGB1 PARP2 PCNA PARP1 FEN1 MPG PNKP OGG1 UNG POLD3 POLD4 NTHL1 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 POLD2 NEIL2 APEX1 POLE3 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling ACTA2 COL1A1 CXCR4 MAPK8 TGFB1 STAT1 STAT3 SOCS5 CCL11 TNFRSF1A NFKB1 IL4 SOCS1 IL19 CCNB1 MAPK1 TNF RAC1 MAPK3 JAK1 IL20RA MAPK14 IL20RB MUC5AC G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling RHPN2 HEL-S-15 MYBPH PIK3CD CIT MAPK10 ARHGDIG WASL PIP4K2A MYL1 ROCK1 WAS ROCK2 SH3RF1 PIK3CA ARHGDIB HEL-S-80p LIMK1 ARHA PIK3R2 CDC42 CALM1 IQGAP1 TNK2 CYFIP1 RPS6KB1 PKN1 GNA13 ARHGEF1 RAC1 CFL2 PFN1 RTKN 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation LEP POMC GHSR GHRL MC4R SIM1 INSR LEPR BDNF INS NTRK2 AgRP NPY CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE HSD3B2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT2 GALNT16 GALNT1 B3GALT2 B3GALT1 B4GALNT1 B4GALT1 CERS3 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 KDSR T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFD IDO1 TGFB1 CXCL12 PDGFA ARG1 VTCN1 VSIR TIGIT VEGFA B2M IL10 SHH TNFRSF4 HAVCR2 IL13 ENTPD1 TNFRSF9 FAS HLA-A PDCD1LG2 IL4 IL6 FAP NR1i1 PDGFD CTLA4 CCL17 PDCD1 PDGFC ICOS CCL22 TNLG5A CXCR4 LGALS9 CD40 TNFSF6 CD80 CD40LG TNLG2B CD226 NT5E VEGFB VEGFC NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining PRKDC POLL WRN POLM NHEJ1 XRCC5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome MMP9 CAMK2A CDKN2A BDNF SRC SHC1 AGAP2 HCN1 FYN RPTOR PTPN11 DEPTOR MLST8 EIF4E GRIA2 GAD1 EPHA4 RPS6KB1 RHEB AKT1S1 DAG1 TSC2 APP TSC1 ARAF ARC CLTB DLG4 CYFIP2 GRIP1 CPT1A SH3GL1 GRIP2 ARHGAP32 ABCD3 KCNC1 DLGAP3 TTI1 ALDH5A1 TBC1D7 PICK1 EPS8L1 NF1 CYFIP1 FMR1 GRIN2B SYNGAP1 PTEN PPP3CA SHANK1 SLC6A1 ALDH3A2 HOMER1 MAP1B PLCB1 BRAF CAMK1 AKAP5 GRIN1 MAPK1 KRAS KCND2 MAP2K1 MAP2K2 RAF1 EIF4G1 ABAT EIF4EBP2 DUSP3 PRKCA DICER1 EEF1A1 PRKAR1A TARBP2 AGO2 DKFZp762B153 GPHN RAP1GAP PLCG1 NTRK2 GABRG2 SH3GL3 MTOR EIF4A1 CLTC CLTA AP2A1 GABRB2 AP2S1 CLTCL1 PPP2R5B AP2M1 CREB1 CNR1 GRB2 SOS1 PTPN5 CAMK4 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism EBP CD36 CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR FDFT1 DGAT1 SQLE ABCG8 ABCG5 APOA4 MTTP APOB LDLR ACAT2 HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK MVD SLC27A4 SAR1B MGAT1 NPC1L1 FABP2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 PTGS1 NR1C1 MVD PTGS2 WNT1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CREBBP HDAC10 SRC STIM1 NRG1 GRM6 GRIA2 GRIN3B GRIN3A GAD1 GRIA3 GRIA4 SDCBP STAT3 CRTC1 HEL-S-162eP ARC PDIA2 DLG4 GRIP1 SLC6A13 DLGAP3 SLC6A11 PICK1 FRMPD3 ADARB1 CACNG8 SLC6A12 CACNG2 EFNB2 NETO2 CPEB3 CABIN1 ARHGEF9 GABRR3 SLC1A1 GRM3 GABRR1 NPTN NRXN3 GRIN2B ADIJ ADII NWD1 SLC6A8 SNX27 GLS2 ATAD1 SYVN1 LHFPL4 SLC6A1 SNX14 HOMER1 PLCB1 STAT1 CDH2 GRIN1 GRIK5 SLC1A2 GRIK3 GRIK1 MAPK1 GRM2 ERBB4 GRM4 MAPK3 GRM8 MAP2K1 FFAR1 ORAI1 MBD5 SUMO1 HDAC1 ABAT GNA11 SLC7A11 PRKCA PPP2CA DKFZp762B153 PIG59 GRIK2 GABRG2 SH3GL2 SLC1A3 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG1 SLC32A1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 CS ALDH3A2 ACSS2 ACO2 ALDH9A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT PRF1 FOXO1 GATA2 MYC CCL5 TNF CCL2 CCL4 CCL1 ADAM17 ADAM10 FCGR3A IFNG CD226 CSF2 MICA BMI1 KLRK1 NCR3LG1 MICB CD96 NCR1 CCL3 NCR3 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAP3K21 MAPK9 MAPK8 ARAF BRAF MAP3K1 PARP14 MAP2K3 MAPK1 MAP2K4 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 PARP1 RAF1 MAP3K8 MAP3K7 MAP3K12 TNKS ATF4 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA LAG3 TGFB1 CXCL12 CCR2 VEGFA NRP1 HLA-DRB1 KDR FAS CSF1R IFITM2 CSF1 CCL5 CCR5 BAG3 HLA-DRA CCL2 CTLA4 CXCR4 TNFSF6 CD80 ITGB6 CSF2 CXCR3 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN1 PLAGL1 PCM1 ACTR1B KIAA0753 CEP170 BMERB1 DCTN6 OFD1 NDE1 ABCC6 DCTN4 MARF1 CEP20 DCP1A GATA3 ACTR10 DCP2 RAPGEF4 RAP1A DISC1 PLK1 ABCC1 PAFAH1B1 PLAG1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 PIK3R5 CACNA1A PRKCZ MAPK8 INSR PDX1 SLC2A2 SURF1 PHKA2 IRS1 IKBKB SOCS4 MAPK1 TNF INS-IGF2 MAFA MTOR FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 FOXP3 IL6R IL2 IL7R IL6 IL2RG STAT3 STAT5B CD80 IL2RA IL6ST IL2RB CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 IKBKB CHUK RELA REL NFKBIA IKBKG NFKBIE ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 LMF1 LDLR PLTP GPIHBP1 LPL ANGPTL4 APOA5 ANGPTL8 APOC2 ANGPTL3 LIPC APOA2 SEL1L RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 RALBP1 EXOC2 EXOC8 YBX3 KRAS RAC1 NRAS RAC3 HRAS RALA WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath GSK3B MAPK9 MAPK8 TSC2 CSNK1D TSC1 CSNK1G1 AXIN1 ROR2 FRAT1 CSNK1A1 CSNK1E CTNNB1 LRP5 NLK MAPK1 LRP6 SOX1 ARHA RYK NFATC2 ROR1 PI4K2A MTOR APC CDK6 CTBP1 BCL9 ARRB2 PPARG LEF1 PRKCB GSK3A MAP3K7 TCF4 DVL1 STM7 DVL2 TCF7L2 PRKCA TCF3 DVL3 RAC1 CCND1 GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RAD1 RAD9B CHEK1 RAD9A ATRIP RPA3 RPA1 HUS1 ATR TOPBP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis GPC6 COL1A1 COL3A1 SPARC YAP1 SNAI2 EDNRA TEAD4 TWIST1 PBX3 THBS2 TEAD2 TEAD3 NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway ABCC5 HGF NRG1 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 TGFB1 TXN SERPINA1 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 SLC2A3 GSTM3 SLC2A2 ABCC3 SLC5A1 HEL-S-128m SLC6A5 SLC5A2 SLC6A7 SLC6A20 SLC6A8 SLC6A9 DNAJB1 SLC5A5 GSTM5 SLC6A1 EGR1 SLC6A2 TGFBR2 SLC2A14 SLC6A19 SLC2A11 UGT2B7 ABCC2 SLC2A10 SLC6A18 SLC2A13 SLC2A12 GSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A8 HBEGF RXRA HEL-75 GCLC GSTM2 NFE2L2 GSTA5 GSTA4 CYP2A6 GSTA3 SLC6A3 SLC39A9 UGT1A1 EPHA2 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC7A11 ALDH3A1 FTH1 SLC39A8 SLC2A9 GSTM4 SRXN1 SLC2A6 SLC2A7 SLC2A8 KEAP1 MAFG ME1 SLC39A14 GPX2 HEL-S-25 FTL HEL-S-22 SLC5A12 SLC5A10 HMOX1 UGT1A4 UGT1A7 TXNRD3 MAFF ADH7 GCLM FGF13 HSP90AB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 APP PSEN2 SIRT1 PSEN1 GDF8 PSENEN BACE1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 ID2 ID3 CCNE1 ID1 PAX8 RBL2 RBL1 RB1 CDK2 PAX2 MYOD1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGV PIGY PIGM PIGC DPM2 PIGB PIGW PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index TLX2 HDAC5 STAT3 LEFTY1 TLX1 TLX3 LEFTY2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 LTC4S PTGS2 ALOX5 ALOX15B ALOX15 ALOX5AP PLA2G5 PLA2G6 PTGS1 PTGIS PLA2G4B PRXL2B PTGES OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response MAPK10 CASP9 CASP3 BAK1 APAF1 TRAF3 TRAF2 TRAF6 C5AR1 MAP3K1 CDKN1C NFKB1 MAP2K4 TNF MAPK13 BAD GADD45A PCNA C1R CDC42 BCL2 CDKN1B C1QB C1QA TNK2 C4B_2 C2 CDKN1A C3AR1 TNFRSF1B BAG4 CR2 TRAF1 NFKBIE CYCS C1QC HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PLCB4 PRKD3 PLCB1 EGFR SMAD2 PLCB2 FLT1 INSR CDH6 FGFR4 CDH2 CDH16 IGF1R KDR PDGFRA CTNNB1 PRKAA2 MET PRKAG1 FLT3 PRKAG2 PRKAG3 FGFR2 PRKAA1 LEF1 PRKACG EPHA2 PRKAB2 PRKCH PRKCB PRKAB1 GNA11 PRKCE PRKCA NTRK1 TCF7L2 TCF7L1 CDH9 KIT CDH8 PRKAR1B GNAL PRKAR1A CDH4 PRKCI CDH10 PRKCQ CDH11 CDH12 CDH15 CDH17 CDH19 NF2 PRKCZ CDH24 NGFR WWTR1 YAP1 GNAI3 CSF1R NTRK2 ARHA GNAS MTOR CDC42 FGFR1 FLT4 CDH18 LATS1 PLCB3 TEAD4 LATS2 RAC1 TEAD2 TEAD3 FGFR3 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CCND2 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 TFAP2A WNT5B WIF1 SOST LEF1 CCND3 NKD1 NKD2 MAP3K7 DVL1 DVL2 TCF7L2 TCF3 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 MACROH2A2 ATF3 CXXC4 PORCN GSK3B CDK8 WNT2B HNRNPK NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 FRAT1 FRAT2 AXIN2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CDK6 CTBP1 FOSL1 FZD1 RUVBL1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 APC2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders TF PANK2 CYBRD1 HFE2 HAMP HEPH FTL STEAP3 FTH1 UQCRFS1 CP TFRC HFE TFR2 SLC40A1 SLC11A2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 PPP5C TSC2 PPM1D RBBP8 RNF20 MRE11A MDC1 ATMIN RIF1 CEP63 IKBKG KAT5 TRIM28 RAD50 TP53BP1 NFKB1 LMNB2 CDK2 NHEJ1 MAPK12 MAPK13 ATF2 MAPK11 MAPK14 MTOR PRKDC HMGN1 ATM RNF168 NBN ATR SMC1A RNF8 AURKB HEL-S-102 PPP2CA STK11 CDK5 CHEK2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2B P2RY6 P2RY4 P2RY2 P2RY1 LPAR4 ADORA2A LTB4R SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer SERPINB2 IRF7 CDKN2A SMAD4 INHBA BRAF IGF1 CEBPB IGF1R IL24 SRC INS MAP2K3 MAPK1 MAP2K1 MAPK14 LAMP2 IL6ST MLST8 BCL2 RAF1 ATG3 CDKN1B GABARAPL2 PLAT ATG12 SLC39A2 IGFBP5 SLC39A1 ATG16L1 SLC39A3 AKT1S1 IRF1 IL6R MAP1LC3A MAP1LC3C SQSTM1 IFNG RB1 SH3GLB1 UVRAG ATG10 BMP2 GSK3B HMGA1 CD44 COL1A1 DKFZp762B153 COL3A1 RB1CC1 SPARC TGFB1 CDC25B JUN ING1 COL10A1 GABARAPL1 THBS1 TNLG1B ATG14 ATG5 RNASEL VTN IL6 GABARAP CXCL8 AMBRA1 IFI16 CREG1 RSL1D1 ULK1 MTOR IL3 PCNA MDM2 KMT2A CDKN1A PTEN IFNB1 IL1B BMI1 HRAS CXCL1 CXCL14 IGFBP7 IL1A MMP14 CCL3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling PAK1 RELA HEL-S-81p GAB2 VAV1 SH2B3 ZAP70 GRAP2 SHC1 PDPK1 LCP2 CARD11 BCL10 MAPK1 FYN MAPK3 NFATC2 LAT ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 RAF1 MAP3K8 MAP3K7 REL PTK2B PRKCQ LCK MAP4K1 MAPK9 MAPK8 CD3G CD3E CHUK CD3D CD8A TRAF6 CRK IKBKG WAS PLCG1 JUN NFATC1 NFKB1 MAP3K14 ITK CRKL PSTPIP1 RIPK2 FYB1 PIK3R2 PIK3R1 CDC42 ICOS CBL NCK1 VAV3 FOS IKBKB CREB1 HRAS GRB2 SOS1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GCK GLS UGDH LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 CD36 BMP1 FGFR1 GLUD1 FGFR4 PSAT1 PLCG1 P4HA2 PSPH ALDH18A1 HEL-S-133P ARHA PHGDH P3H4 P3H3 PLOD1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR AGXT GLYCTK AQP9 KHK GPD1 LIPE ALDOB PC FBP1 GPD2 PFKL HEL-S-162eP ENO1 HEL-S-68p MGLL HEL-S-165mP PGAM1 HEL-S-49 G6PC1 HEL-S-87p PNPLA2 AQP7 PCK1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling OXTR PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP9 CASP3 APAF1 PINK1 UBE2L6 PARK2 UBE2L3 CASP2 DDC MAPK12 MAPK13 MAPK11 MAPK14 GPR37 UBB SEPT5 LRRK2 SLC6A3 ATXN2 HEL-S-67p CASP6 CCNE1 UBA7 TH EPRS1 SYT11 HEL-117 UBE2J2 CCNE2 UBE2J1 SNCA HTRA2 UBE2G1 UBE2G2 SNCAIP CYCS IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFD MMP9 TGFB1 CXCL12 VEGFA IL10 IL13 IL2 IL4 IL6 IL5 CXCL8 CCL5 TNF CCL28 CCL2 CXCL5 CCL20 LGALS9 IL25 REG4 IL12B IL12A IFNG IL23A IL1B IL17F CSF2 IL17D IL17C IL17B CXCL1 VEGFB IL17A VEGFC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 YES1 WWTR1 H4C9 SRRT FGF7A HIST1H4L SOX12 POU3F1 UTF1 SOX15 ZSCAN10 SOX4 SOX2 TEAD2 POU3F2 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair PCNA POLE4 RFC2 MSH6 RFC3 RFC4 RFC1 POLD3 MSH2 POLD4 POLE LIG1 PMS2 POLE2 POLD2 POLE3 RPA3 RPA1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP8 ATP6 COX17 ATP5MC2 ATP5J ATP5MC3 COX7A2 ATP5H COX11 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 SLC25A14 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HEL-S-123m SLC25A27 UCP3 UCP2 NDUFA7 NDUFA6 NDUFA5 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX4I1 COX6A1 COX8A COX6B1 COX7A1 SDHC SDHD UQCRB SDHB COX3 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 UQCRC2 SURF1 COX1 SDHA SLC25A5 SLC25A4 SLC25A6 UCP1 NDUFA13 COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 NDUFA9 NDUFA12 NDUFA10 COX6A2 HEL-S-271 ATP5IF1 COX7A2L SCO1 ND1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ACTA2 ITGB1 MAPK10 ITGB7 NF2 MAPK9 MAP4K1 MAPK8 PAK1 MAP4K2 WWTR1 YAP1 MAP4K3 SRC CTNNB1 CTNNA1 ACTG1 ITGB5 ITGB4 ITGB3 YWHAQ PS1TP5BP1 ITGB8 SGMS1 ITGB6 ACTA1 LATS1 LIMD1 TEAD4 PAK6 PAK4 TEAD2 TEAD3 HEL-S-31 ACTG2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 EGF ZEB2 LTBP1 ZNF423 BAMBI LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway SHC1 ERBB2 SOS2 SHC4 SHC2 SHC3 EGF RPS6KB2 E2F2 RPS6KB1 NBN DDB2 PIK3R3 RB1 CETN3 GADD45B GADD45G CCND1 ARAF BAX FZD10 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B GADD45A PIK3R2 PIK3R1 TNFSF11 FZD1 WNT10B WNT10A FZD3 ATM FZD2 FZD5 FZD7 FZD9 ATR FZD8 PTEN BRCA1 BRCA2 HRAS APC2 NCOA1 FGF23 EGFR BAK1 MRE11A BRAF NRAS IGF1 CSNK1A1 WNT7B IGF1R WNT7A RAD50 RAD51 FGF10 CTNNB1 CDK4 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 NR3A2 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 PGR RAF1 LEF1 HES1 DVL1 HES5 DVL2 FGF8A TCF7L2 DVL3 NFKB2 TCF7L1 WNT1 KIT WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD POLK AXIN1 AXIN2 SKP1 JUN WNT16 PIK3CA SP1 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC CSNK1A1L CDK6 JAG2 E2F3 PARP1 FGF18 FGFR1 FLT4 HEY2 FGF2 FGF7B FGF7A FOS DLL3 DLL4 CDKN1A FGF5C GRB2 SOS1 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes MMP9 SMAD2 ANGPT1 MAPK9 MAPK8 KITLG TGFB1 RELA CXCL12 RELB TGFBR1 DKFZp781O1323 KDR NFKB1 MAPK1 MAPK3 SMAD1 NOTCH3 NOTCH1 SMAD9 CXCR4 EPHB4 FLT4 EPHB2 DLL4 NFKB2 HIF1A KIT ACVRL1 REL CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYL11 TNNT1 ACTA2 MYL3 TNNT3 MYH8 MYH4 MYH7 MYL1 TNNC1 TNNI1 HEL-S-273 HEL-S-108 RYR1 RYR2 ACTG1 TPM3 TPM1 RYR3 PS1TP5BP1 MYH6 ACTA1 MYH13 TNNI2 MYL2 TNNI3 TNNC2 MYH1 ACTG2 MYH2 MYL6 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine AANAT SPR PAH MAOA ASMT JDP1 PTS PNMT TH DHFR DBH NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 RELA DDX3X TRAF3 CASP10 MAP3K1 ISG15 TNF IFNK MAPK12 MAPK13 MAPK11 MAPK14 NFKBIA TBKBP1 NFKBIB IKBKE ATG12 MAP3K7 IFNE RIPK1 IFNG TANK MAPK10 MAPK9 MAPK8 OTUD5 CHUK CXCL12 TRAF2 TRAF6 DDX3Y TBK1 DHX58 IKBKG TRIM25 AZI2 SIKE1 RNF125 NFKB1 CYLD PIN1 ATG5 CXCL8 MAVS SNW1 CASP8 RIGI FADD TRADD IFNB1 IKBKB MITA NLRX1 IFNA1 IFIH1 IRF3 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 LBR HMGCR NR1H2 CH25H FDFT1 IDI2 PLPP6 FADS2 SCD CYP7A1 CYP27A1 MYLIP ELOVL5 ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK HMGCS1 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP6 ATP5MC2 ATP5J ATP5MC3 ATP5H NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 HEL-S-123m NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COXFA4L2 ATP6AP2 NDUFS8 NDUFS3 COXFA4 NDUFA11 NDUFA9 NDUFA10 HEL-S-271 ND1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 NF1 KRAS NRAS BRAF HRAS PTPN11 GRB2 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling GSK3B CREBBP CASP9 PDGFA IKBKG FOXO1 PIK3CA NFKB1 CTNNB1 AKT3 KLK3 MAPK1 KRAS BAD MAP2K1 MTOR NFKBIA MAP2K2 BCL2 RAF1 CDKN1B MDM2 CDKN1A GRB2 CCND1 SOS1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IF2B1 IL23R IL17RC STAT3 IL12RB1 IL12B TYK2 CXCL8 IL23A IL1B IL17F HLA-C TNF CCL20 CXCL1 IL17A CCR6 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM1 RYR1 MYLK PLCB1 PPP1R14A MYL1 ROCK1 ROCK2 IL13 GDI1 ADRB2 HEL-S-80p ARHA OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 NFKB1 IKBKB CHUK MAPK1 RELA ITGB3 MAP3K14 SPP1 MAPK3 MAP2K1 ITGAV HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG3 RB1CC1 ATG12 WIPI1 ATG16L1 MAP1LC3A ATG5 ZFYVE1 ATG16L2 ATG10 ULK2 MTOR ULK1 PIK3R4 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 ABCC2 AKR1D1 AKR1C4 SLC27A5 SLC51A HSD3B7 ABCB4 SLC51B ABCB1 BAAT ABCC3 CYP7B1 SLCO1B1 FABP6 SLC10A2 AMACR ABCB11 SLC27A2 ATP8B1 HSD17B4 CYP7A1 ABCD3 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 HSD17B2 F13B HSD3B1 HSD17B3 HSD17B7 CYP17A1 HSD17B4 HSD17B1 HSD3B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB4 PIK3CD PLCB1 PLCB2 TSC2 TSC1 YAP1 ROCK1 PKN2 PIK3CA AKT3 MAPK1 ARHA MTOR PIK3R2 MOB1A PIK3R1 PKN3 PKN1 PIK3R3 LATS1 PLCB3 TEAD4 LATS2 TEAD2 TEAD3 TRIO SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways CALCA HEL-S-14 MYLK PLCB1 GNAI1 MYL1 CAD HEL-S-7a GNG13 EDNRA RAMP1 GNA15 MAPK1 NPY GNAS MAP2K1 COX2 CALCRL GNB5 ECE1 EDNRB CALM1 ADRB1 NPY1R RIIAD1 ATP2A2 RAF1 ADRA1A EDN1 PRKCA PTGIR LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 CS SLC19A2 NONO SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B CYP2C8 CYP8B1 COX1 PLCB1 ALOX12 LTC4S PTGS2 CYP2C9 ALOX5 CYP2B6 ALOX15 HPGD CYP7B1 CYP4F2 GPX4 FADS2 PLA1A CYP7A1 EPHX2 PRXL2B CYP27A1 PTGES VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism HEL-S-53e RXRB CD36 RXRG HEL-S-4 CYP26A1 SULT1A1 SULT2B1 ADH1A CYP26B1 RLBP1 RPE65 DGAT1 SDR16C5 RXRA MAPK1 RDH12 ABCG8 AWAT2 ABCG5 LRAT BCO1 SCARB1 RDH8 ALDH1A3 CRABP2 RETSAT RARA CRABP1 LPL DHRS3 RBP7 RBP4 RBP2 RBP1 RDH5 CYP2E1 ALDH1A2 NR1B3 RDH10 NPC1L1 RARB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 ST3GAL5 A3GALT2 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 TNLG7C DKK1 EDARADD DKK4 LTB WNT3 PTCH1 RELB EDAR SHH SOSTDC1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH GH1 GNRH1 SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 HEL-S-53e GLYCTK KHK HEL-S-49 SORD ALDOB G6PC1 FBP1 PFKL SLC2A2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI NEDD4 TGFBR2 TGFBR1 ATG16L1 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing SRPK2 PPM1G RNMT YBX1 SUPT5H HNRNPH1 NCBP1 NCBP2 SMC1A SRSF9 TMED10 PTBP1 METTL3 SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A NONO PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 HNRNPD SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA FUS SNRPB DHX8 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 WDR57 SFRS3 CLK4 SFPQ LSM2 CLK2 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 DICER1 CSTF2T U2AF1 PABPN1 POLR2A U2AF2 TRA2B SNRPB2 SF3B1 DDX1 SF3A1 SF3A2 HNRNPK SPOP HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRPK1 SRP54 DHX15 PRPF40A SRSF10 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB4 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 RETN RELA CHUK PLCG2 PLCG1 IKBKG PIK3CA NFKB1 IL6 AKT3 CXCL8 MAPK1 TNF MAPK3 MAPK14 NFKBIA PLCE1 IL12B IL12A PLCB3 IKBKB LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis MMP9 CXCL2 CCR2 PDGFA IGF1 CEBPB CCL11 HGF CCL5 TNF SFTPC CCL2 CCL4 TGFA EGF BMP7 NFE2L2 IL12B TERT TIMP1 CALCA TGFB1 CSF3 FAM13A SFTPA2 MT2A KPG_011 ATP11A CTGF RTEL1 DPP9 STN1 CMA1 IL13 MUC5B HMOX1 IL4 IL6 IL5 SERPINA1 CXCL8 SPP1 FGF7 CCR3 ELMOD2 PTX3 SFTPA1 FGF2 GREM1 EDN1 MMP2 IL1B CSF2 SKIL CCL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK HEL-S-162eP PFKL ENO1 ENO2 PFKM ENO3 HEL-S-68p MPC2 PGAM2 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-30 HEL-S-87p HK2 PCK1 SLC2A4 PDHA1 MDH2 GOT2 PKLR ALDOB PC FBP1 SLC2A3 SLC2A2 LDHB MPC1 HEL-S-133P DLAT HK3 G6PC1 HEL-S-32 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO GOT2 AGXT SLC26A1 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FBP1 VEGFA FOXO1 PIK3CA HEL-S-68p KDR MYC HIF1A PGAM1 HEL-S-133P OTUD7B G6PC1 OTUB2 USP37 U2AF2 USP44 SIRT7 MTOR HK2 VHL USP28 USP19 OTUD6B ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 KCNQ2 BRSK1 SEMA3A ANK2 L1CAM SCN5A SPTAN1 PRRT2 CSNK2A1 EIF2A CSNK2A2 SCN2A DDIT3 CSNK2B SNAP25 ATF4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap MTR CTH GCLM CBS METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 ANXA2 MTTP APOB LDLR APOE LPL ABCA1 LIPG APOC2 LIPC APOA2 PCSK9 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BIRC5 HEL113 APP AXIN1 HEL-S-89n NFKB1 THBS1 SOCS3 NRG1 YBX3 MAPK1 JUND TNF RIPK2 F2R ERBB3 GCLC ERN1 CTNNA1 IL7R CDKN1B CUL5 APOE BEX3 RNF7 NQO1 HELLS HDAC1 NET1 CARD14 TNFRSF21 RPS6KB1 PKN1 VAV3 HEL-S-7 CDKN1A SQSTM1 HEL-S-102 PTK2B TNFRSF10B TRAF1 HSPD1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DCTN1 YWHAQ DCTN6 TH PAFAH1B1 DCTN5 DCTN3 HEL-S-1 YWHAG NDEL1 DCTN4 HEL-S-77 YWHAZ DDC PPP2CA HEL2 CDK5 DBH DISC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MYLK PIP4K2A VAV1 DOCK1 PDGFRA RRAS2 SOS2 WASF1 EGF FGFR2 RAC3 PXN PIK3R3 STM7 ITGA1 PAK6 PIP5K1A PIP4K2B PAK4 PIP5K1C MYL3 WAS ARHGEF4 RRAS CYFIP2 BDKRB1 PIK3R4 ACTN1 PIK3R2 PIK3R1 GNA13 RAC1 APC2 CD14 FGF23 EGFR PAK1 MYL1 FGFR4 ARHGEF7 PDGFA BRAF NRAS CHRM1 FGF10 BDKRB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAF1 ACTG1 HEL114 F2 FGF8A ARHGAP35 CFL2 FGF6B PFN1 EZR HEL-S-15 PIK3CD CHRM2 CHRM3 CRK ROCK1 ROCK2 GNG12 PIK3CA TMSB4X LIMK1 ARHA FGF20 FGF22 FGF7 FGF21 FGF8 F2R FGF9 FGF16 APC FGF14 CDC42 PIK3R5 FGF13 FGF18 FGF12 IQGAP1 FGFR1 PIK3C2G PIK3C2A PIK3C2B PS1TP5BP1 FGF2 FGF7B NCKAP1 CHRM4 FGF7A CHRM5 HEL70 MYH10 RDX RASSF7 ARHGEF1 ARPC5 MAPK6 SSH2 SSH3 MAPK4 BRK1 FGF5C PIP5KL1 FGD1 CSK WASF2 BAIAP2 MOS SOS1 ABI2 FGFR3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 NFE2L2 MAPK8 HEL-S-22 NQO1 CES1 ABCC6 JUN ABCC3 FOS HMOX1 ABCG2 EPHX1 MAPK12 MAPK13 SRXN1 MAPK11 GCLM MAPK14 NQO2 KEAP1 GCLC IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling MMP9 ACTA2 RORC DCSTAMP SMAD2 MAPK9 MAPK8 CASP3 RELA STAT1 STAT3 BAX IL10 JUN NFATC1 PIK3CA TYK2 ATP6V0D2 SOCS3 IL6 CXCL8 MAPK1 TNF DDIT3 MAPK3 MAPK14 NFKBIA COX2 CCL20 IL33 TNFSF11 EPHA3 DEFB4B MPO CTSK IL10RB IL1B CSF2 JAK1 IL20RA IL17A IF2G MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IRAK1 TIFA TLR4 UBE2V1 MYD88 TRAF6 TLR1 JUN NFKB1 TLR10 TLR5 HEL-S-71 TLR9 TLR8 TLR7 IL1A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells KIR2DL1 KIR2DL3 ELF3 NLRP7 NLRP2 VAV1 PLCG1 PRKCA LCP2 IFNG CSF2 HLA-C TNF RAC1 FYN LAT TYROBP PRKCQ SYK PTPN6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR1D2 RORC RORA RXRB NR2F6 RXRG NR2E1 NR2F1 NR0B1 NR5A2 NR1H2 NR1C1 NR1A2 RXRA NR1I3 NR1i1 NR5A1 ROR1 NR2F2 NR3A2 NR1i2 PGR RARA NR2C2 NR2A1 PPARG NR3C1 ESRRB NR1C2 NR1B3 NR1H3 THRA ESRRA RARB FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 LMF1 LDLR PLTP GPIHBP1 APOA5 APOC2 LPL LIPC APOA2 SEL1L SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network SELENOK PTGS2 RELA INSR CRP HEL-S-97n FLAD1 PRDX3 PRDX5 INS HEL-S-2a TNF GPX1 CCL2 HEL-S-44 HEL-75 SCARB1 APOB SERPINA3 LDLR SAA4 HBB MTR PLAT PLG HEL-S-302 SELENOF MPO SELENOI SELENOH ABCA1 SEPHS2 FGA HBA2 GPX6 F2 PTGS1 SELENOO HEL-S-78p NFKB2 F7 SELENON IFNG SELENOM ALB SELENOP SAA1 SELENOW SAA2 GPX4 SELENOV SELENOT MSRB1 SELS GPX2 ALOX5 ALOX15B ALOX5AP DIO1 CBS TXN NFKB1 TXNRD3 IL6 CTH XDH GPX3 TXNRD2 IL1B KMO KYNU DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis OXCT1 HMGCS1 ACAT1 ACAT2 BDH1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 HFE2 HAMP BMP6 ID1 HFE TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma ELOC BIRC7 CREBBP TGFB1 EP300 TFEB VEGFA CTSK SETD2 FH CADM2 DVL2 ARNT2 CDKN1A PRCC RBX1 COL21A1 EGLN1 HIF1A EGLN3 EGLN2 VHL TGFA SFPQ BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 GSTM1 MPO CYP2E1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders XDH ADA DGUOK HPRT1 TPMT RRM2B ADSL HEL-S-70p PNP MOCOS AMPD1 PFAS PAICS APRT AOX1 IMPDH1 ADSS 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV SDF2L1 CAMK2A NEDD4 PPIB RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RNF19B RPS12 VPREB1 RPS9 CWC22 AQR RPS7 RPS8 CRNKL1 RPS5 PDIA4 RAB36 DNAJB11 RPSA PPIE RPS6 SNRNP200 GNAZ CD79B UBA6 CABP1 CD79A AK8 CWC15 TDRD3 GGTLC2 ZNF280A RPS15A HEL-S-107 RPS19 ARIH1 RPS3 CCDC116 BUD31 RPS2 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A RILP UGGT1 RPS26 PPIL1 CDC5L RPS28 IGLL5 XAB2 CHEK1 RPS29 YPEL1 PPIL4 RPS20 PPIL6 RPS21 RPS24 RPS23 IGLL1 PARK2 UBE3A UBE2L3 HEL-S-89n IQUB HEL-S-99n ROPN1L RSPH6A PDIA2 DNAJB13 NME5 DYDC1 RSPH9 RSPH3 MDM2 XBP1 RSPH14 SNRPD2 SNRPD1 SNRPD3 PAK1 SNRPG SNRPE SNRPF CAMK1 SNRPB FAU PRPF8 MAPK1 WDR57 HEL-S-125m DHX16 RPS11 RPS27A SNRPA1 SF3B5 SF3B2 SNRPB2 SF3B1 SF3A1 ELOC SF3A2 PHF5A HYOU1 RBX1 SNW1 CANX BCR SOX9 CBL PTPA CAMK4 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy STX1A CAMK2A DAG1 RAB1A SCN8A ZNF547 TRAPPC3 PRRT2 GIGYF1 TRAPPC6B KCNQ5 NEDD4 AKAP5 SCN2A SCN4B RAB11A SNAP25 KCNQ2 CALM1 KCNQ3 FGF13 FGF12 PRKCE BACE1 VAMP2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 HSD17B2 HSD3B1 HSD17B3 SULT1A1 UGT1A1 CYP17A1 HSD3B2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation NCKAP1L VAV1 GATA2 KLF1 CSF1 CD34 NFATC2 MYB NOTCH1 MUC1 CXCR4 RUNX1 SPI1 ITGB3 LEF1 ITGA2B XB KITLG CSF3 EPO TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 GATA1 ABO MXI1 NFE2 IL6 IL5 RIOK3 NR1A2 MHC2TA FLI1 ARHH GP9 TPO HES6 IL3 PIM1 LYL1 FOS IL1B CSF2 ACVR1B FOSB IL1A EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 IL1B PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CSRP2 CTNNB1 CDK4 SOX4 RB1 PMAIP1 MACROH2A1 CCND1 MED1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease HBA2 TLR4 IL18 HBB IL1B BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 LDLR FGF8A ABCB11 MAPK1 FGFR4 ABCG8 MAPK3 ABCG5 FXR1 CYP7A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling RAF1 EPOR STAT1 STAT3 CISH EPO SRC SHC1 SOCS1 IRS1 PTPRC MAPK1 STAT5B MAPK3 PTPRU MAP2K1 GRB2 MAP2K2 SOS1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PIK3CD PTGER3 EGFR PTGS2 BRAF NRAS SRC PIK3CA AKT3 MAPK1 KRAS PTGER4 MAPK3 HRAS PLA1A PTGER2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR STAT3 MAPK1 MAPK3 JAK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL6 STAT2 HEL-S-10 STAT1 STAT3 JAK1 IL10 IL10RB IL10RA IL1A CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR NRAS IGF1R INS PIK3CA CDK4 AKT3 IRS1 ERBB2 CDK2 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 PIK3R5 CDK6 RAF1 CDKN1B PIK3C2G PIK3C2A PIK3C2B CCNE1 PIK3R3 CDKN1A HRAS CCND1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis HEL-S-53e TGFB1 ASCL1 STAT3 CDKN1C NKX2-2 SHH DDC GBX2 MSX1 SOX2 FGF8 NKX6-1 PITX3 EN2 EN1 LMX1A LMX1B OTX2 FOXA2 SLC6A3 TH NEUROD1 NEUROG2 SLC18A2 WNT1 RET GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling CDKN2A CCND2 EGFR EP300 NRAS BRAF FOXO1 IGF1R SRC PDGFRA PDPK1 CDK4 AKT3 IRS1 MAP2K3 ERBB2 CDK2 MAP2K4 MAPK1 KRAS MET MAPK3 MAP2K6 MAP2K1 MAP2K2 ERBB3 RAF1 CDKN1B FGFR2 PRKCH PRKCB PRKCA RB1 CDKN2B PRKCI PRKCQ CDKN2C CCND1 SPRY2 PIK3CD MAP2K5 PRKCZ TSC2 TSC1 ARAF PLCG2 PLCG1 MSH6 PIK3CA ERRFI1 PIK3R2 PIK3R1 CDK6 MDM4 FGFR1 PIK3C2G FOXO3A FOXO4 PIK3C2A NF1 MDM2 PIK3C2B CCNE1 ATM CBL CDKN1A PTEN BRCA1 BRCA2 HRAS GRB2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A1 SLC6A19 SLC6A20 SLC36A2 CLTRN SLC3A2 SLC7A7 SLC1A1 SLC7A9 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome PCM1 MRE11A OFD1 SHH RAD50 PDE6D PDE6A FLNA PDE6G INVS NPHP3 ZNF423 RHEB DVL1 SUFU RAB8A DVL3 CEP164 BBS9 BBS7 BBS5 CEP290 ATF4 BBS4 MYO6 KAT5 RP2 TMEM216 CEP104 ARL3 ARHA ARL13B TMEM67 INPP5E MTOR BBS2 NEK8 BBS1 CETN2 CCP110 AHI-1 PARP1 ARR3 TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP41 CEP97 CC2D2A ARMC9 ATM RPGRIP1L TMEM138 ARL2 NPHP1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 B9D1 B9D2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ASL OTC NAGS GLS2 ASS1 ARG1 SLC25A13 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GALT1 B4GALNT1 B4GALT4 B3GNT5 ST3GAL5 A3GALT2 GBA2 UGT8 UGCG NEU3 NEU4 A4GALT GLA B4GALT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 GSK3B PDE4A TFAM PDE4B GUCY1B1 PARK2 HEL-S-162eP PDE4D NRF1 AKT3 PRKG1 PPARGC1A NOS2 PDE5A ZNF746 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TLR4 MMP9 CXCL2 MBP CCR2 BDNF OMG GFAP PLA2G2A FKBP1A CCL2 CDKN1B C1QB SLIT2 EPHA4 PLA2G5 PLA2G6 TNLG7A IFNG RB1 NTN1 APEX1 CDC2 MIF CCND1 CCNG1 RGMA TGFB1 FCGR2A IL2 PLXNA2 IL4 CXCL8 GADD45A SELP EFNB2 NOX4 AIF1 AQP1 LTB PPP3CA RAC1 EGR1 ANXA1 MMP12 ZFP36 IL1A SEMA6A PDYN BCAN KLK8 EGFR BTG2 HEL113 NCAN AQP4 PRB1 PTGS2 PRB2 TACR1 VCAN TNFSF13 GAP43 CD47 ACAN SLIT1 SLIT3 LILRB3 GRIN1 CDK4 MYC CDK2 MAPK1 TNF MAPK3 CSPG4 GJA1 RTN4 PRKCA IL1R1 COL2A1 GDNF E2F5 RTN4R LEP NGFR CASP3 ARG1 COL4A1 ROCK2 LTB4R IL6 ARHA NOS2 SOX9 CDC42 FOXO3A ROS1 RHOB XYLT1 FOS IL1B CHST11 CXCL1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A PPP2R2C PPP2R2B PYGB PHKG2 PYGM AGL PHKB PHKA1 PHKA2 HK2 CALM1 PPP2R1B PPP2R1A GYS2 GYS1 PPP2R2A PPP2R5E GYG1 GSK3A PPP2R5B PPP2R3B PPP2R5A PPP2R5D PPP2R5C PTPA HK3 PYGL PPP2CA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 COA3 AS3MT UQCRFS1 HEL-S-44 SDHA HEL-S-21 ND1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 PTGS2 EPHX2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A ITGB1 PAK1 CTNND2 ARHGEF7 GRIN1 RAP1A DLG4 HCN1 SPAAR ARHGAP44 SHARPIN LZTS3 ADGRL1 CDC42 SPTAN1 GRIA2 PS1TP5BP1 SHANK3 MAP3K7 GRIN2B SYNGAP1 DLGAP1 HRAS BAIAP2 HOMER1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TOMM70 IRF7 AGTR2 REN TRAF3 TRAF6 TBK1 TMPRSS2 NFKB1 CTSL MAVS RIGI ACE2 PHB2 NDUFB9 ACAD9 AGTR1 TLR7 NDUFAF1 IKBKE ECSIT TICAM1 NFKB2 CGAS NLRX1 MITA IFIH1 IRF3 TLR3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection TLR4 IRF7 CCND2 STAT2 TYK2 NFKBIA NFKBIB IKBKE CDKN1B OAS1 OAS2 CLEC4M BBC3 OAS3 IRF9 CCND3 IFNA6 IL12B MAP3K7 IL12A CCNE2 PIK3R3 STAT5B JAK3 CCND1 IL2RA IL2RB CD46 MAPK10 MAPK9 IL2RG MAPK8 CD3G CD3E STAT3 CD3D EIF3S3 BAX FCGR2B CSNK2A1 CSNK2A3 CSNK2A2 IL2 ADAR CASP8 CSNK2B PIK3R2 PIK3R1 HEL-S-103 FADD HEL-S-72p CCNE1 EIF2AK2 TRADD IKBKB JAK1 HSPA2 IFIH1 IRF3 IL1A IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 BAK1 RELA STAT1 IFNA21 TRAF3 IF1AA9 FAS CDK4 TNFAIP3 IFNA8 CDK2 MX1 LNIR CD209 BCL2L1 BCL2 RCHY1 RAB9A RAB9B TNFSF6 IFNA7 NFKB2 EIF2S1 CYCS IRAK1 PIK3CD IRAK4 CASP9 MYD88 TP73 CASP3 CHUK APAF1 TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD TLR9 TLR7 CDK6 HEL70 FOS IFNB1 IL1B EIF2AK1 EIF2AK4 IFNA1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB SLC16A7 SLC1A2 SLC4A4 SLC16A3 HEL-S-133P NUDT14 CA4 HEL-76 SLC2A3 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAP2K5 YAP1 AMOT PIK3CA NFKB1 MAP2K3 MAP2K4 MAPK1 ARHA RAC1 MAP2K6 MAPK3 MAP2K1 MTOR MAP2K2 TRIO MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYLK HEL114 LPP ITGB3 MFAP5 PLCG1 JUN ITGAV PXN TJP1 CREB1 MAPK1 MAPK3 MYL2 PRKCQ ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway KHK SORD ALDOB AKR1B1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway SLC12A2 CFTR ADCY6 FLT1 NRAS BRAF IGF1 WNT7B IGF1R PDE1A WNT7A SRC KDR CTNNB1 MYC ERBB2 PRKAA2 TNF KRAS MAPK3 MAP2K2 WNT5B PRKAG1 PRKAG2 EGF PRKAG3 PRKAA1 PRKACG PRKAB2 RHEB PRKAB1 GNA11 DVL1 DVL2 DVL3 WNT1 KCNN4 WNT3 WNT4 WNT3A STK11 CCND1 VEGFB GSK3B WNT2B TSC2 GNAI1 TSC1 FZD10 PLCG2 WNT16 GNAI3 JUN PKD1 SFRP4 GNAS MTOR SSTR2 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT9B FZD5 RPS6KA1 FZD7 WNT9A FZD9 WNT8A FZD8 FOS WNT8B IKBKB HRAS EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 LTC4S ALOX5 ALOX15B ALOX15 KPG_011 HEL-S-298 EHHADH HPGD FPR2 CYP4A22 LTB4R NR1C2 NR1C1 TRPA1 CYP4F2 CYP4A11 TRPV1 PTGR1 CYP4F12 ACOX1 ACOX3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH3 NOTCH1 MAML3 JAG2 PSEN2 ADAM10 CHUK DLK2 LEF1 MFAP1 PSEN1 MFAP2 HES1 DNER DLL3 DLL4 RRAS MAML2 MAML1 RBPJ NOTCH2 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 EBI3 GPR183 CRP TNFSF13 FOXO1 ISG15 IFITM1 MFGE8 CCL19 PTPRC TNF PAX5 ZEB2 CCL21 CXCR4 CD40 CD80 CD82 CD79A BACH2 IFIT2 C4A BLNK IRF4 CD19 CCR7 FCRL5 IRF8 TNLG7A IL12A CXCR5 CD1D SLAMF7 HEL-S-62p SH2D1A CD40LG IFNG CR2 CR1 MS4A1 CD22 IL-21 CXCL12 BCL6 TBX21 IFNAR2 IL10 IL2 IL4 IL6 BCR SYK TLR7 PDCD1 ICOS ICOSLG PRDM1 SELL CD69 HEL-S-72p XBP1 TMSB10 ITGAX MAF CXCL13 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 SELP ITGB1 KNG1 SELPLG HEL-S-62p IL6 CXCL8 C6 C7 TNF VCAM1 IL1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders UMPS RRM2B DPYS DHODH NT5C3A HEL74 TYMP HEL-S-29 RRM1 RRM2 TYMS DPYD GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GABBR2 CASR GRM2 GPRC5A GRM4 GPRC5D GRM8 GPRC5C GRM3 GRM6 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C1R MASP2 MASP1 CFD C1QB C1QA C4B_2 C2 C4A C8A CFP HEL-S-62p C6 C7 C8G C9 CD55 C1QC ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B MEF2C MEF2B MEF2D EP300 CAMK2G FOXO1 NR1C1 RXRA PRKAA2 ATF2 MAPK14 PRKAG1 PRKAG2 PPP3R1 PPP3R2 PRKAG3 PPARGC1B TFAM PRKAA1 PPARG FOXO3A UCP3 HDAC1 UCP2 SIRT1 SIRT3 PRKAB2 GABPA PRMT1 PRKAB1 NRF1 NR1C2 CREB1 PPP3CA PPARGC1A PPP3CC TFB1M TFB2M NCOA1 PPRC1 ESRRA MED1 MYBBP1A CAMK4 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNJ2 HCN2 TMSB4X ERG GJA1 HAND2 IGF1 HCN4 KCNE1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling ANGPT2 BIRC5 HIF1AN BNIP3L ANGPT1 PTGS2 BAK1 BAX EPO VEGFA PFKL HEL-S-68p BCL2A1 HEL-S-30 NOS2 BNIP3 TGFA BCL2L1 PDHA1 IGFBP1 SLC2A3 EDN1 IGFBP2 HIF1A EGLN1 HEL-S-133P PMAIP1 MCL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA NTRK2 AKT3 SORT1 KIDINS220 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 TDO2 NMNAT1 HEL-S-90n HAAO KMO KYNU AFMID T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling GSK3B CALM1 CD8B1 DYRK2 CD8A PLCG1 CSNK1A1 ZAP70 GSK3A NFKB1 IL2 PRKCA PTEN PPP3CA ITK FYN NFATC2 NFKBIA LCK CTLA4 DYRK1A PTPN6 PDCD1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO3A1 SLC16A2 SLCO4A1 SLCO1A2 SLC16A10 SLCO1C1 SLC7A5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation TAF5 GTF2B GTF2H2C_2 TAF9 CCNH GTF2E1 GTF2E2 GTF2H2 GTF2F2 POLR2B GTF2H3 POLR2F POLR2G POLR2H ERCC2 POLR2I POLR2J MNAT1 POLR2K TAF13 POLR3B POLR3D TAF7 TAF6 POLR3H TBP POLR3K POLR1A POLR1D HEL-S-28 TAF12 CDK7 POLR2C POLR2A POLR3E ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway SERPINB2 EGFR POLK TGFB1 EP300 MYOF BAX JUN SLC7A5 SRC UGT1A4 IL2 AHRR UGT1A7 JUND TNF CAP2 PTGES3 MGST1 NFE2L2 CDKN1B CES3 UGT1A3 NQO1 CYP1A2 CYP1B1 CDC37 UGT1A1 UGT1A9 IGFBP1 CYP1A1 IL12B HES1 IL12A JUNB AIP ALDH3A1 IFNG IL1B AHR IL17B NCOA1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 ACADS ACSL3 ACADM PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 BATF CD8B1 CD3G STAT3 CD3E CD3D CD8A JUN ZAP70 NFATC1 HLA-DRB1 NFKB1 HLA-A PDCD1LG2 IFNG NFATC3 NFATC2 PTPN11 NFATC4 LCK PDCD1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling HCLS1 CAMK2A RELA GAB2 BRAF VAV1 VAV2 FOXO1 SHC1 PDPK1 MYC CARD11 BCL10 MAPK1 PTPRC FYN MAP2K6 NFATC3 NFATC2 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 RAF1 CD79B CD79A BLNK CD19 PRKCB MAP3K7 STM7 GTF2I CR2 PIP5K1A REL PIP5K1C BLK BTK CD22 LCK GSK3B MAP4K1 MAPK9 MAPK8 CHUK BCL6 PLCG2 CRK IKBKG PLCG1 JUN NFKB1 MAX RASGRP3 CRKL INPP5D LYN SYK PIK3R2 PIK3R1 CDC42 RAPGEF1 CD81 LAT2 DAPP1 PTPN18 TIEG2 PIK3AP1 CBL RPS6KA1 NCK1 GSK3A IKBKB CREB1 MAPK4 RAC1 HRAS GRB2 SOS1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ITPR2 CYP21A2 AGTR2 PLCB2 STAR CALML6 REN CALML3 CALML4 CAMK1 CAMK2G CMA1 ATF1 ATF2 CYP11B2 AGTR1 HSD3B2 CYP11A1 CALM1 CREB3L3 CREB3L4 HSD3B1 CTSG CAMK1D CAMK1G CREB3L2 CREB3 CREB1 CREB5 CAMK2D ATF6B CAMK4 ATF4 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF RAF1 TSC2 STAT3 TSC1 NRAS EREG BTC RHEB TYK2 PTEN AKT3 KRAS SOS2 JAK1 HRAS RPTOR JAK3 MTOR GRB2 TGFA SOS1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKB1 RAF1 RRAS IKBKB CHUK MAPK1 MAP3K14 MAP2K6 TRAF6 MAP3K1 NFKBIA IKBKG SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events FOS ARC PLCD4 NLGN1 5HT1A CRHR1 PLEK PPP3CA CRH HTR2A PRKCB SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 NLRP3 TERF2IP REN TRAF3 TRAF6 SIRT6 RPS6KA1 ECSIT NDUFAF2 NFKB1 IL18 IL6 TERF2 MAVS TNF NLRX1 MITA ACE2 ACAD9 NDUFAF1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4E IFRD1 ADAM10 NR4A3 VEGFA HEL-S-52 IL18 IL1R1 IFNG CYR61 DUSP14 HBEGF JUND EIF4EBP1 GDF8 ANKRD1 MYOG ATF3 IL1A OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CCND2 TSC2 TSC1 PRLR CEBPB RAD51 CDK4 SYNE2 NR1i1 NR5A1 TBP MTOR NR3A2 NCOR1 PGR CDKN1B FSHR ATM FMR1 GJA4 LHCGR FIGLA DAZL GDF9 DMC1 CREB1 ZP3 ZP2 EGR1 SMPD1 PTGER2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG ID2 STAT3 RUNX2 SPI1 IKZF1 IRF4 IRF8 TCF4 CSF1 BATF3 CSF2 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDKN2A ACTL6B EZH2 ACTL6A CDK4 PTCH1 EED SMARCD1 CDK6 SMARCC1 SMARCA4 SMO SMARCD2 ARID1A SMARCC2 SMARCD3 SUZ12 GLI3 ARID1B RB1 H3F3B GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAP3K7 MAPK8 IKBKB CHUK RELA CD40 IKBKG EPHB2 ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CDKL5 MEF2C FRS3 CAMK2A DOK5 KCNN2 DOCK3 KCNA3 NCAM1 ARHG SIRPA SH2B1 RANBP9 MARCKS VAV2 BDNF SRC SHC1 KSR1 PDPK1 EIF4EBP1 PRKAA2 FYN SHC4 YBX1 SHC2 PTPN11 SHC3 NFATC4 NFKBIA EIF4E GRIA2 RPS6 RPS6KA5 GRIA3 RPS6KB1 SQSTM1 ACACB STAT5B PTK2B PTPRF MAPK10 MAPK9 TSC2 MAPK8 EIF2S2 STAT3 CRTC1 MAP3K2 CSNK2A1 RAP1A GRIP1 PIK3R2 PIK3R1 RASGRF1 CYFIP1 GRIN2B IKBKB RAC1 HRAS IGF2BP1 RELA STAT1 CDH2 MAP3K1 CAMK1 GRIN1 CTNNB1 CDK5R1 RPS6KA3 IRS1 MAPK1 MAPK3 MAP2K1 MAPK14 MAP2K2 ADAM17 RAF1 PRKAA1 NCF1 NTRK1 NTF3 NTRK3 PPP2CA TIAM1 EIF2S1 CDK5 GSK3B HEL-S-15 MAP2K5 NGFR EEF2 CASP3 CHUK TRAF6 PLCG1 IKBKG JUN NFKB1 MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 BAD MTOR APC CDC42 NCF2 FOXO3A GABRB3 RPS6KA1 NCK2 NCK1 VAV3 NGF CREB1 FRS2 CNR1 GRB2 SYN1 CAMK4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2L1 BCL2 FADD CASP9 CASP3 BBC3 APAF1 BAX TNFSF6 TNF MAPK12 CASP8 MAPK13 BAD MAPK11 MAPK14 MCL1 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP2C8 PTGS2 CYP2C9 CYP1A2 ALOX15 EPHX3 ALOX12B PTGS1 CYP2C19 CYP3A4 CYP4A11 GPX4 ALOXE3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 MCL1 ZAP70 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLC34A3 ITGB1 EGFR HDAC2 CFTR ANKRD35 EIF4A3 GPR89B AKAP10 SLK SUMO2 MAGOH FURIN NUDT17 HEL-S-76p HLA-B HLA-F HLA-G HLA-E RBCK1 MET SLC22A4 PEX11B CLCN3 BCL2L13 TNFRSF14 FARP2 FLT3 NHERF1 UBE2I POLR3GL CD160 PYM1 CXCR4 PDZK1IP1 POLR3C POLR3F POLR3G SIRT1 MITD1 DDIT4 LAMTOR1 IFNG LCK HFE2 HAMP STAT3 CD3D TXN CCAR2 NFKB1 HLA-A HLA-C PEX19 ZFHX3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR17 P2RY11 HTR1F ADORA2B OR2F1 F2RL2 OR2A4 GPR18 ACKR3 HRH3 ADRA1B ADRA1A PTGFR NPFFR2 RRH GPR174 PTGDR2 GPR173 GPR171 CMKLR2 CMKLR1 GPR37L1 FPRL2 TRHR TBXA2R PTGDR OR1I1 MC2R PTGIR GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 F2RL1 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW CCR8 CCR4 GPR39 OR5F1 GPR34 GPR31 NPFFR1 AVPR1A OR5V1 OPN1MW OR3A2 OPRD1 OR10H1 OR10H3 GPR45 GPR68 CCR3 OR10H2 GPR42 OR2AG1 CHML OPRK1 EDNRB P2RY10 P2RY14 NPY1R GPR52 GPR50 GPR4 GPR15 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 OR2B2 CCR6 HTR1E HTR1D HTR1B NMUR2 NMUR1 OR7A10 OR14J1 MLNR HTR2B PRLHR OR8D2 OR7A17 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 CX3CR1 OR1E2 NPY4R BDKRB2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OPN1SW ACKR4 FFAR1 ACKR2 OR11A1 KPG_010 GPR83 LPAR4 KPG_011 AVPR2 GPER CCRL2 CHRM4 CHRM5 PTGER4 PTGER2 AGTR2 CCR2 GPR75 AVPR1B NMBR CXCR4 C3AR1 PTGER1 PTGER3 GHSR RHO C5AR2 NPY2R FPR1 HTR7 BDKRB1 GPR37 MTNR1A ADRB1 MTNR1B GPR161 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 P2RY1 CHRM1 ADRA2C ADRA2B MGRA ADRA2A MC3R AGTR1 OXTR ADORA2A HTR5A 5HT1A CNR2 CCR7 CXCR5 HCRTR2 HCRTR1 MC4R CHRM2 CHRM3 OR1G1 ADRA1D GPR32 HTR2A FPR2 P2RY6 HTR4 P2RY4 GRPR HTR6 ADRB3 P2RY2 LTB4R EDNRA CCR5 OR1F1 F2R OR2H1 FFAR3 FFAR2 SSTR2 CCKBR FSHR OR3A3 OR10A5 OR3A1 OR1E1 LHCGR ADRB2 IL8RB CXCR1 CNR1 CXCR3 OR2B6 NTSR1 MC1R P2RY13 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK NFE2L2 MAPK8 SP1 MAFF MAP2K1 MAP2K2 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 PHF19 CD40 STAT4 ITGAV HLA-DRB1 MHC2TA SLC22A4 TRAF1 BLK CTLA4 IL2RA IL6ST CCR6 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 COX1 MB HBB XDH NOS2 AOX1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDKN2A EGFR SMAD4 RELA TRAF3 MAPKAP1 NRAS VEGFA IGF1R CTNNB1 PDPK1 CDK4 AKT3 ERBB2 PRKAA2 EIF4EBP1 FKBP1A KRAS RPTOR IRF6 MLST8 TP63 NOTCH2 NOTCH1 EIF4E RPS6KB2 NFE2L2 FGFR2 SESN2 PRKAA1 CSMD3 RPS6 DDIT4 SESN1 RHEB TERT NFKB2 RB1 REL STK11 CCND1 KEAP1 AJUBA TSC2 TSC1 BIRC2 PIK3CA NFKB1 MAML1 CASP8 FAT1 MTOR PIK3R2 PIK3R1 NUMB PIK3R5 CDK6 FADD FGFR1 CDKN1A PTEN RICTOR HRAS TGFBR2 FGFR3 SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism SHMT1 HEL-S-51e PHGDH TYMS SRR PSAT1 DHFR PSPH CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 RELA IFNA21 CASP10 IF1AA9 ISG15 IFNA8 CCL5 CCL4 NFKBIA IL33 NFKBIB POLR3GL IKBKE POLR3C POLR3F ZBP1 POLR3G AIM2 ATG12 POLR2L TREX1 IFNA6 POLR3A RIPK3 IFNA7 RIPK1 CHUK TBK1 IKBKG TRIM25 POLR2F RNF125 POLR2H NFKB1 CYLD ATG5 ADAR POLR2K IL6 POLR3B MAVS POLR3D CASP8 RIGI IFNA2 POLR3H POLR3K POLR1C POLR1D FADD PYCARD CCL4L2 TRADD IL18 IFNB1 IKBKB IL1B CGAS MITA NLRX1 POLR3E IFNA1 IRF3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 CHD3 HBB GATAD2B MTA2 NR2C2 HDAC1 tal-1 HBG2 LDB1 LMO2 HBD BCL11A HBG1 HBE1 GATA1 KDM1A ZFPM1 KLF1 ZBTB7A PPARGC1A MYB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA DPYS TYMP TK1 POLE4 RRM1 RRM2 UCK2 UCK1 UMPS POLR3GL POLR3C POLR3F POLR3G POLR2L TYMS ENPP1 POLR3A POLD3 POLD4 POLE RRM2B ZNRD1 HEL74 ENTPD3 NME2 NME3 CTPS2 CTPS1 POLE2 NME4 POLR2A DCTD POLE3 NME6 NME7 CMPK1 CMPK2 POLR1F UPRT DCTPP1 PRIM2 POLA2 DTYMK DHODH POLR2D NT5M POLR2J3 DUT PNPT1 POLR2J2 POLA1 CAD POLR2B ENTPD1 POLR2G POLR2H POLR2I POLR2J POLR2K POLR3B POLR3D POLR3H ENPP3 POLR3K POLR1A POLR1C POLR1D PRIM1 POLR2C POLD2 POLR3E DPYD GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG SLC5A1 PCSK1 SLC2A2 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 PTGS1 5HT1A FAAH TRPA1 PTGS2 CACNA1H TRPV1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 ETS2 BIRC5 EGF CD81 EGFR STAT3 IGF1 CD63 KDR PTEN IL6 GATA4 HEL-S-102 SPP1 HEL-S-44 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis MEF2C MIXL1 MEF2B KLF6 STAT2 CYP26A1 MEF2D NR2F1 PRLR CEBPA CEBPB EGR2 KLF5 CEBPD LIF GATA3 GATA2 CYP26B1 KLF15 SOCS3 SOCS1 TWIST1 GATA4 SLC2A4 RARA LIPE NR1C2 TRIB3 HIF1A RB1 PTGIS STAT5B GADD45B PCK2 AHR MIF HMGA1 RORA CFD RXRG WWTR1 TGFB1 STAT3 E2F4 SFRP4 DDIT3 SCD GADD45A GH1 FZD1 WNT10B PPARGC1A NCOA1 LPIN1 LPIN2 LPIN3 STAT1 ID3 FOXC2 IGF1 BMP4 FOXO1 INS FAS CTNNB1 NR1C1 IRS1 RXRA IRS4 TNF WNT5B IL6ST NCOR1 MBNL1 HNF1A BMP1 LPL NR3C1 CELF1 ZMPSTE24 LMNA CISD1 DVL1 RBL2 RBL1 WNT1 NR1H3 BMP2 OSM LEP RETN CNTFR GTF3A BSCL2 ADFP NDN BMP3 PLIN1 FRZB IL6 SPOCK1 SP1 UCP1 GDF10 KLF7 PCK1 NCOR2 NAMPT PPARG PNPLA3 CDKN1A CREB1 ASIP SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs LPAR1 MTNR1A PTGER1 PTGER3 GPR50 MTNR1B CNR2 S1PR3 PTGFR TBXA2R PTGDR PTGIR S1PR2 S1PR4 PTGER4 CNR1 S1PR1 PTGER2 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs HTR1D HTR1B HTR1F CHRM2 CHRM3 HTR2B ADRA1D HTR2A HTR4 HTR6 ADRB3 CHRM1 HTR7 ADRA2C ADRA2B ADRA2A ADRB1 ADRA1B HTR5A ADRA1A 5HT1A CHRM4 CHRM5 ADRB2 DRD1 DRD2 DRD3 DRD4 HRH1 HRH2 DRD5 HTR1E ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 AGTR2 TGFB1 REN CTSG CMA1 BDKRB2 ATP6AP2 NR3C2 MGRA BDKRB1 ACE2 CYP11B2 AGTR1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 SELE ITGB1 ITGB7 SELPLG ITGA2 MADCAM1 VCAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation GHRH BTBD9 GHRL STAR HTR2A NPY2R ADA SLC29A1 IL6 HEL-S-2 CHRNB2 UTS2R MRGPRX2 OXTR ADORA2A MTNR1B NLGN1 OXT UTS2 TH NPS NPAS2 FOS DRD1 PTGDR IL18 DRD2 DRD3 DLAT CRH CACNA1I HCRTR2 HCRTR1 PER3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway MEF2C CASP3 NCAM1 CTCF EP300 STAT3 CHD2 SMC3 HEL-S-89n NFKB1 PRNP RXRA MAPK1 FYN MAPK3 TBP HEL-S-269 RFX5 HEL-S-125m BCL2 PAX5 BATF RAD21 FGFR1 SPI1 POU2F2 IRF4 BCL11A CREB1 CASP12 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation TACI TLR4 SMCR8 IFT46 C9orf72 IFT70B WDR26 GPS1 MIEF2 RAB10 RASD1 RANBP9 RMND5A FNIP1 FNIP2 NR1H2 MYO16 MKLN1 GID4 MYO15A DRG2 RPTOR BCL2L11 MLST8 PRKAG2 PRKAB1 IRF8 HEL-S-133P G6PC1 CDC2 MYH2 WWTR1 APP PPP1R14A STAT3 BCL6 BAX YAP1 PARK2 IFT172 BLM IFT74 CLTB GRIP1 ULK1 PRDM1 IFT81 IFT27 IFT25 MED9 RAI1 GPR85 PTEN CLEC16A CARM1 RELA TNFSF13 MYC TNF FOXA1 CRY2 CRY1 PRKAA1 FOXA2 ATG101 TRAF3IP1 RAB8A FLCN IFT52 NR1H3 CFL2 PRKCI PARD3 IFT57 PER1 FLII IFT80 MYD88 RB1CC1 NT5M ARG2 TFEB BIRC2 ROCK1 JUN PARD6B NFKB1 LIMK1 MAP3K14 ARHA MTOR FERD3L HES6 PCK1 ALKBH5 CLTC MAEA DENR CLTA MIGA1 ARMC8 RNF41 TOM1L2 FHOD1 RRAGA PEMT LLGL1 DRC5 SHMT1 CLUAP1 DRC7 DRC8 COPS7A PLD6 RAB39B COPS4 IFT20 COPS6 IFT22 COPS5 DRC1 COPS8 GDI2 CREB1 WDR41 IL1B IFT56 ATPAF2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 LIPT2 LIPT1 GLDC AMT DLD HSCB LIAS GCSH NFU1 BOLA3 ISCU PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PKN2 KDR PDGFRA PDPK1 HGF PRKAA2 SOS2 MET RPTOR TGFA BCL2L11 MLST8 PDGFC FLT3 EIF4E EIF4B EGF RPS6KB2 FGFR2 GYS2 GYS1 RPS6 RPS6KB1 RHEB PIK3R3 G6PC1 JAK3 STK11 MCL1 CCND1 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 IL4 SGK1 PIK3R2 SYK PIK3R1 IL3 IL3RA GH1 MDM2 PKN3 PKN1 PTEN BRCA1 IKBKB RAC1 JAK1 HRAS IFNA13 IFNA14 EGFR NTF4 IFNA16 IFNA17 FLT3LG IFNA10 RELA IFNA21 FGFR4 IF1AA9 NRAS VEGFA FGF10 IFNA8 IL7 CSF1 IRS1 MAP2K1 MAP2K2 HEL-S-125m BCL2L1 TCL1B TCL1A PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 CDC37 TNFSF6 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 GNGT2 RBL2 FGF8A OSMR COL2A1 KIT PHLPP2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD NGFR CASP9 KITLG GHB3 CSF3 CHUK CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 CSF1R NTRK2 EFNA5 EFNA4 CHAD FGF20 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 EFNA3 PCK1 FGF14 EFNA2 PIK3R5 CDK6 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 G6PC2 ITGB4 FLT4 LAMC2 FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 IFNA1 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C TLR4 ANGPT4 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 PRL LAMB2 PPP2R3A EPOR PPP2R2C PRLR PPP2R2B PPP2R2D BDNF EIF4EBP1 GHB2 GHR CSH2 G6PC3 COL6A6 COL6A5 CDKN1B ITGB3 IGF2 ITGA2B CCND3 IFNA6 CD19 LAMC1 IBSP IL6R CCNE2 ITGA1 COL6A1 PCK2 ITGA2 COMP COL4A3 COL9A1 COL9A3 COL9A2 COL4A5 COL1A1 LAMA5 LAMB4 SGK2 THBS1 VTN SPP1 LAMB1 CCNE1 FGF23 TNC FLT1 INSR PDGFA IGF1 IGF1R INS CHRM1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 ATF2 COL1A2 MYB PDGFD BCL2 PRKAA1 PHLPP1 PPP2R2A PPP2R3B PRKCA NTRK1 NTF3 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 NFKB1 GNG13 IL6 GNB2 GNB1 IFNA2 GNB4 F2R GNB3 GNB5 GNGT1 PIK3AP1 CREB3L2 CREB3 CREB1 ATF6B HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis SYT2 HNRNPL CALM1 CAMK2A BCL2 CCND2 PRL NCAM1 RPS6KA5 RPS6KA1 NRXN1 BDNF NRXN3 NRXN2 PRKCA DRD1 NGF CAMKK1 CREB1 CAMKK2 MAPK1 PPARGC1A MAPK14 CAMK4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 RYR1 CCK RYR2 PLCB1 CCKBR DAGLA GNAI1 RYR3 CNR1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PANK2 RB1CC1 TSC2 TSC1 FTL WIPI1 WIPI2 ATG5 ATG14 CP RPTOR MTOR ULK1 PIK3R4 DEPTOR MLST8 WDR45 ACACA DCAF17 C19orf12 ATG3 COASY FA2H PRKAA1 ATG12 RHEB ATG16L1 PLA2G6 AKT1S1 ATG101 ATG2A MAP1LC3A SPTLC1 ATG10 STK11 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P REN CTSG CMA1 PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs AGTR2 TACR1 CCR2 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 CX3CR1 NPY4R BDKRB2 MC3R AGTR1 OXTR AVPR1B NMBR CXCR4 ATP8A1 TACR2 TACR3 CXCR6 TAC4 CCR7 CXCR5 FPRL2 TRHR C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 CCR10 HCRTR1 NTSR2 CCR1 GHSR MC4R BRS3 C5AR1 NPY2R CCKAR FPR2 FPR1 GRPR CCR8 CCR4 EDNRA AVPR2 AVPR1A GNRHR CCR5 OPRD1 BDKRB1 TSHR CCR3 OPRK1 EDNRB NPY1R SSTR2 CCKBR FSHR MC5R LHCGR IL8RB FY CXCR1 CXCR3 NTSR1 MC1R CCR6 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3 RNF8 NIPBL H2AX MDC1 ATM RNF168 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer GLS PYCR2 PSAT1 HEL-S-162eP PFKL PSPH ACLY ENO1 HEL-S-68p PGAM1 HEL-S-30 PAICS PDHA1 MDH2 GOT2 FASN SLC16A3 GLUD1 HEL-S-51e ALDOB TIGAR SDHB ACO2 FH RPIA SUCLG2 HEL-S-133P HK3 HEL107 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 SMAD4 CHUK RELA NR3C1 MAP3K1 MED14 IKBKG NFATC1 NFKB1 IL6 MAP2K3 IKBKB RXRA PPP3CA NR1i1 TNF MAP2K6 MAPK14 NFKBIA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA AKT3 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling MAPK8 KITLG EP300 STAT1 STAT3 GAB2 CRK PLCG1 VAV1 GRB7 SRC SHC1 SH2B2 RPS6KA3 SOCS1 MAPK1 CRKL FYN MAPK3 INPP5D BAD PTPN11 MAP2K1 MAPK14 LYN MAP2K2 TEC PIK3R2 PTPN6 PIK3R1 RAF1 FOXO3A RPS6 CBL GRB10 RPS6KA1 SOCS6 RPS6KB1 MATK PRKCB PRKCA DOK1 KIT STAT5B HRAS BTK GRB2 SOS1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2 UGT1A4 NAT2 CYP1A2 SULT1A1 UGT1A9 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo KLF4 ZFP36L2 SOX8 MXD1 ZFP42 POU5F1 GATA3 GATA2 SIX3 DPPA3 SOX2 TFAP2B IRX5 SOX11 ELAVL1 IRF4 NANOGNB FOXD1 DNMT3L KHSRP MYBL1 ZAR1 ARGFX TCF7L1 DLX2 PADI6 BARX2 LEUTX TPRX1 E2F5 TBX3 DPRX CDX2 ZSCAN4 MACROH2A2 HMGA1 HNRNPAB MTA3 FOXQ1 AQP3 NR3C2 DDIT3 PBX1 SMARCA4 AQP9 ATP1A1 NKX2-1 TEAD4 BATF3 EGR1 MOS FOSB ESRRA ZFP36 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 SCARB1 LDLR PLTP APOE LPL LIPC VLDLR APOA2 DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RPA4 MCM5 MCM6 PRIM2 POLA2 CDC45 RFC2 POLA1 RFC3 RFC4 CDK2 RPA3 RPA1 PCNA MCM2 GMNN POLD3 RFC1 PRIM1 POLD4 UBC POLE ORC6 ORC3 POLE2 ORC2 POLD2 CDC6 MCM7 ORC1L MCM10 DBF4 CDT1 MCM3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways HDAC2 CYP46A1 MBP NR1H2 BDNF EIF4EBP1 PRKAA2 RPTOR DEPTOR BCL2L11 PRKAG1 MLST8 PRKAG2 EIF4E EGF PRKAG3 C1QA RPS6KA5 PRKAB2 RPS6KB1 RHEB PRKAB1 SREBF2 AKT1S1 HMGCS1 ABCG1 PIK3R3 ABCG4 PI3 MAPK10 HAP1 MAPK9 RAB3GAP1 TSC2 MAPK8 TSC1 BAX CASP8 PIK3R4 PIK3R2 PIK3R1 AHI-1 APOE PTEN IKBKB PPARGC1A SIN3A HRAS EGFR SLC12A2 HTT AKT3 MAP2K4 MAPK1 KIF5A MAPK3 MAP2K1 MAP2K2 MAP3K10 BCL2L1 BCL2 RAF1 PRKAA1 HDAC1 NEUROD1 ABCA1 HEL-S-29 REST PIK3CD CYP51A1 CASP3 DHCR7 HMGCR PIK3CA NFKB1 IL6 NTRK2 SP1 GABRG2 BAD BNIP3 MTOR PIK3R5 PIK3C2G PIK3C2A OPA1 PIK3C2B GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 CREB1 GABRA3 GABRG3 IL1B GABRG1 RICTOR SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2 PAPSS2 PAPSS1 SULT1B1 SULT2A1 SULT1A1 SULT1E1 SULT2B1 SULT1C3 SULT6B1 SULT1C2 SULT1C4 HEL-75 SULT1A4 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity MARK1 BAK1 CASP10 MBP FAS CX3CR1 CX3CL1 MFGE8 AXL FCN1 FCN2 C1QB C1QA ITGB3 COLEC11 DIABLO PROS1 TNFSF6 C4B_2 C2 C4BPA C4A C8A HEL-S-62p C3AR1 IFNG MBL2 CR2 CR1 PRKCI PARD3 CYCS C1QC SERPING1 MASP2 MASP1 CD46 CAP1 CFD CASP9 PRKCZ CASP3 TGFB1 PATJ FCN3 APAF1 CFH BAX C4BPB C5AR2 DLGAP5 ATP11A CFI ATP11C C5AR1 SCRIB PLSCR3 PLSCR4 TYRO3 PARD6B LLGL2 PARD6A CRB2 CFP COLEC12 CRB1 PALS1 COLEC10 VTN PARD6G CLU ATP10A C6 C7 DEDD C8G CASP8 C9 ATP8B3 CD59 ATP8B2 CD55 ATP8B1 C1R ITGAM ITGAV ITGAX PLSCR1 HTRA2 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling TLR4 CAMK2A CYP21A2 STAR RELA BRAF CTNNB1 PRKAA2 MAPK1 JUND MAPK3 MAP3K5 TFAP2A MAP2K1 MAPK14 NFKBIA ERN1 BCL2 ACACA RAF1 GJA1 HSD3B1 GNAZ PRKCB GNA11 JUNB TCF4 PRKCA CACNA1H PRKCI PRKCQ GSK3B CASP9 MAPK9 CRHR1 MAPK8 CASP3 GNAI1 TGFB1 PLCG2 PLCG1 TRIM28 NFKB1 JUP IL2 SP1 CXCL8 GNB2 ARHA CRHBP GNB1 KRT1 GNAS IVL CRHR2 GNB3 GNAO1 HSD3B2 KRT14 GNB5 ECE1 CYP11A1 POMC PARP1 FOSL2 FOSL1 ARRB2 SULT2A1 FOS IL18 CREB1 CASP12 CRH FOSB SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety POMC PLCD4 ADRA1A 5HT1A PLEK EEF2K HTR2A PRKCB FMR1 FOS ARC PPP3CA CRH TRPV1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling IRAK1 IRAK2 UBE2V1 IRAK4 PRKCZ MAPK9 TAB3 MAPK8 MYD88 RELA CHUK TRAF6 MAP3K1 PLCG1 IKBKG MAP3K2 MAP3K7IP1 JUN NFKB1 MAP2K3 HEL-S-71 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 PIK3R2 PIK3R1 IRAK3 NFKBIB PELI1 HSPB2-C11orf52 ECSIT MAP3K7 SQSTM1 IL1R1 IKBKB IL1B REL MAPKAPK2 IL1A PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYS DHODH TYMP NT5C3A RRM1 RRM2 TYMS CAD ABAT UMPS OTC RRM2B GLS2 HEL74 DPYD OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL1 FADS1 ELOVL5 SCD5 ELOVL6 FASN ELOVL3 FADS2 SCD ACSL1 ELOVL2 FACL4 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 CS PC SDHA HEL-S-26 OGDH ACLY FH DLD SUCLG2 DLAT HEL-S-32 HEL60 PCK1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36B IL36RN STAT1 IL36G IL1F10 GATA3 SOCS3 CSF1 SOCS1 MAPK1 BCL2L11 IL37 POLR2L ANAPC1 ZNRD1 IL1R1 IL23A POLR1F ARF6 PLCG2 POLR2F POLR2H IL2 POLR2K IL6 POLR1A POLR1C POLR1D CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 TTL IL1RL2 NT5DC4 IL1B CSF2 RAC1 IL1RN MERTK CXCL13 GRB2 IL36A IL1A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling EGFR FLT1 RELA INSR FGFR4 BRAF PML CSNK1A1 FOXO1 IGF1R SRC KDR KSR1 SHC1 PDGFRA GAREM2 CTNNB1 MYC AKT3 MAPK1 SOS2 KRAS MET MAPK3 RPTOR MAP2K1 NFKBIA DEPTOR MAP2K2 MLST8 FLT3 ZBTB16 PYGO1 RAF1 BCL9 RARA FGFR2 RUNX1T1 LEF1 EPHA2 RHEB AKT1S1 NR1C2 IL6R NTRK1 TCF3 KIT WNT1 REL CCND1 GSK3B PIK3CD NGFR TSC2 RETN CHUK TSC1 STAT3 IKBKG AXIN2 JUN PIK3CA NFKB1 JUP CSF1R NTRK2 IL6 LRP5 LRP6 ULK2 MTOR APC TTI1 SALL4 FGFR1 FLT4 MDM2 FOS CDKN1A PTEN IKBKB HRAS GRB2 NFKBIE SOS1 FGFR3 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma CDKN2A PAK1 BAK1 NRAS BRAF KDR CDK4 AKT3 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC2 PTPN11 MAP2K1 PDE5A MAP2K2 RAF1 HEL114 E2F2 DDB2 PIK3R3 RB1 KIT GADD45B GADD45G CCND1 PIK3CD POLK CALML6 ARAF EXOC7 BAX CALML3 CALML4 PIK3CA ARHA BAD GADD45A PIK3R2 PIK3R1 CALM1 CDK6 E2F3 RHOB NF1 MDM2 GRM3 PREX2 CDKN1A PTEN RAC1 HRAS GRB2 SOS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia RELA NRAS BRAF PML CEBPA MYC AKT3 EIF4EBP1 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 FLT3 ZBTB16 RAF1 RPS6KB2 RARA RUNX1T1 RUNX1 SPI1 LEF1 MPO RPS6KB1 NR1C2 CCNA2 PIK3R3 TCF7L2 TCF7L1 KIT STAT5B PER2 CCND1 PIK3CD CHUK STAT3 ARAF IKBKG PIK3CA NFKB1 JUP CSF1R BCL2A1 BAD MTOR PIK3R2 PIK3R1 IL3 PIM1 PIM2 ITGAM CEBPE FCGR1A IKBKB CSF2 HRAS GRB2 SOS1 CD14 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TEDC1 TEDC2 IFT46 FBF1 KATNB1 IFT70B TUBD1 KIF3B CEP76 MIB1 TUBE1 KIAA0753 CPLANE2 SASS6 CEP162 OFD1 CIBAR1 CEP44 CEP20 DYNC2I2 CEP19 DYNC2H1 DYNLT1 DYNLT2B TRAF3IP1 DYNC2LI1 IFT52 KIF3A TMEM107 BBS9 BBS7 IFT57 RABL2B BBS5 BBS4 IFT140 DNCL1 IFT80 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 IFT172 TMEM216 WDPCP IFT74 CEP104 CEP192 ARL6 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 SCLT1 IFT81 FUZ TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP97 IFT27 CC2D2A CLUAP1 ARMC9 IFT25 RPGRIP1L PIBF1 IFT20 CPLANE1 TMEM231 TMEM17 TTC23 C2CD3 B9D1 CBY1 IFT56 RAB23 EFCAB7 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 CCDC41 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis GSK3B ATP7B SLC31A1 ATP7A APP CASP3 COX17 MT2A SLC31A2 FOXO1 COX11 JUN COMMD1 MT4 MT3 PIK3CA ATOX1 MT1A MTF1 PRNP MT1F SP1 MT1G MT1B XAF1 STEAP1 STEAP2 MT1E HEL-S-44 CCS APC STEAP4 ADAM17 ADAM10 FOXO3A MDM2 STEAP3 PTEN ADAM9 CCND1 SLC11A2 BACE1 SCO1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence HMGA1 SLC2A4 MDH2 PARP1 GOT2 ELAVL1 NAMPT CCL27 PRKAA1 RELA SIRT1 SIRT3 IL6 IL1B SIRT5 HEL-S-32 NMNAT2 SIRT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 HBA2 HBE1 GATA1 HBB HBZ tal-1 HBG2 LDB1 LMO2 HBD RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MCM6 TTK CDC45 RRM1 RRM2 TOP2A DHFR WEE1 SUV39H1 HMGB1 CDK4 MYC CDK2 MAPK13 RPA3 SMC2 RPA1 NPAT HLTF PLK4 CCDC6 RAF1 CDKN1B RBBP7 HDAC1 CCND3 TYMS E2F2 PRMT2 POLD3 SMC1A CCNA2 CCNE2 POLE TFDP1 CCNB2 RB1 CCNB1 RBBP4 POLE2 CDC2 CCND1 CDT1 CHEK1 FAF1 CDC25B POLA1 SMC3 MSH6 RFC3 RFC4 BARD1 FANCG SAP30 HMGB2 PCNA PRKDC TFDP2 CDK6 E2F3 MDM2 CCNE1 H2AZ1 RBP1 ZNF655 SKP2 PRIM1 CDKN1A SIN3A MCM7 ORC1L MCM3 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA MMACHC MMADHC TCN2 MTR CD320 TCN1 CUBN CBLIF OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy COL1A1 COL3A1 RELA STAT3 RUNX2 FGFR4 RELB CTGF CEBPB ACAN VEGFA JUN PIK3CA KDR COL10A1 NFKB1 AKT3 MAPK1 JUND SPP1 MAPK3 VHL SOX9 FOSL2 FOSL1 FGFR2 FGFR1 CNMD P4HTM GANC DDR2 IBSP JUNB FOS NTRK1 PRKCA LAMTOR1 HIF1A NGF COL2A1 FOSB FGF23 FGFR3 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 ST3GAL5 ST3GAL1 NEU3 B4GALNT1 NEU4 HEXB HEXA ST8SIA1 ST8SIA6 SIAT4C B3GALT4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 FOXL2 BNC1 NR5A1 WT1 AMH DCAF17 ATG9A CYP17A1 NBN LAMC1 ZAR1 ALOX12 STAG3 SLX4 BLM FANCM FANCL WRN FANCA FANCC HSD17B4 HSD17B1 RFWD3 NUP107 ERAL1 PRDM1 SALL4 ATM BMPR1A FMR1 BMPR2 BRCA2 POLR2C PCCA PCCB STAR BMP6 RAD51 NR3A2 TP63 NOTCH2 AMHR2 LMNA PRORP ANTXR1 EIF2B1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 EIF2B2 PREPL MSH4 NOBOX KHDRBS1 AARS2 EIF2B5 AIRE PPM1B HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 TGFBR3 HROB LHX8 MCMDC2 MCM9 ELAVL2 BMP15 POLG LARS2 C1orf146 MRPS22 SIX6OS1 HAX1 PSMC3IP RECQL4 CCDC185 MGME1 C10orf2 MND1 GNAS CENPE POLR3H NLRP11 XPNPEP2 SPATA33 MST1R FSHR FIGLA DAZL CLPP GDF9 DMC1 ZP3 PGRMC1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 PLCB1 RPP38 PRKCB SPHK1 SGMS2 PRKCA CDK4 CDKN1A SGPP1 TERT RB1 UGCG CDK2 MAPK1 S1PR2 SPTLC1 GLB1 S1PR5 S1PR1 DEGS1 MTOR KDSR MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 H2AX CDKN1A MYC CDKN1B CREB1 CCND3 CCNE1 ATM RAD52 CCND1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3C8 EZH2 SET SUV39H2 SUV39H1 SETD2 EHMT1 H3C15 EED KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L EZH1 KMT2C SETD7 PRDM2 KMT2A SMYD2 KMT5B SMYD4 SMYD3 H4C7 H4C9 MLL2 SETDB1 HIST1H4L KMT5C SMYD1 SETD1B SETD1A SETDB2 SETMAR AEBP2 H3F3B ASH1L SETBP1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DICER1 DROSHA RAN TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer MMP9 CDKN2A EGFR TYMP ARAF NRAS BRAF VEGFA SRC THBS1 RASSF1 CDK4 MYC CXCL8 ERBB2 HBEGF MAPK1 KRAS MAP2K1 MAP2K2 PIK3R2 PIK3R1 EGF RAF1 RPS6KA5 MDM2 CDKN1A RB1 MMP2 DAPK2 HRAS UPK3A CCND1 FGFR3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN HIF1A VEGFA VEGFB VEGFC HES1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX14 COA6 COX1 CSRP2BP PET100 FAM36A COX10 CMC1 TMEM177 PNKD COX17 SMIM20 COX7A2 COX11 COX7B COX4I1 SURF1 COA3 COX6A1 COX8A COX2 COX6B1 COX7C COX3 COXFA4 COX5A COX19 COX16 COX18 TACO1 HIGD1A PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway HEL70 RDX ARHA SEPTIN2 MYL2 RAB35 KIF23 EZR OCRL EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects RGS16 PRL KLF2 CXCL12 ERBB4 MYB 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MEF2C PRL ASCL1 SEPTIN2 MROH2A DGKD HJURP ERFE KLHL30 THAP4 RRAGB ACKR3 RRAGD AGAP1 RAMP1 OR6B3 TRPM8 OR6B2 GAL3ST2 MTERF4 RAB27A COPS9 GBX2 SNED1 NFKBIA RTP5 RNPEPL1 PRH MYOG ING5 FARP2 SEPT6 HEL-S-28 KIF1A ILKAP AQP12B AQP12A AGXT DUSP28 CXCR4 GABARAPL2 ANO7 OTOS RPS6 ITGB3 GYS1 ARL4C USP40 ARF5 ASB18 CENPA CYTH2 SPP2 D2HGDH IRF8 ANKMY1 CYTH1 MLPH CAPN10 RAB17 ASB1 ARF1 HAMP CXCL12 TWIST2 UBE2F CALCRL UGT1A3 RAC1 NEU4 CXCL11 SH3BP4 UGT1A8 EGFR TRAF3 PDX1 PDGFA TNF DISC1 UGT1A10 BOK UGT1A1 UGT1A9 ABCA1 HES1 MAP1LC3A TRAF3IP1 MAP1LC3C EEF1A1 PER2 MYOD1 CALCA DKFZp762B153 DTYMK MAP4 JUN UGT1A4 GABARAPL1 UGT1A7 GABARAP SEPTIN4 HES6 GPC1 PDCD1 CALM1 RRAGA IL13RA1 COPS8 IL1B NEDD8 NDUFA10 PPP1R7 ITPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 ZEB2 HDAC2 ELF3 TGFB1 SUZ12 FOXC2 HDAC1 SIRT1 EZH2 SNAI1 SNAI2 SUV39H1 TCF4 KDM1A PRRX1 TWIST1 KLF8 GSC2 SIX1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway CPT2 KLK15 CYP8B1 PLTP FABP1 ACADM SLC27A1 EHHADH UGT1A9 DBI NR1C1 CDK4 MYC APOA5 RXRA NR1H3 APOC3 CPT1A CYP4A11 CDC2 CYP7A1 CCND1 APOA2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 CYP2A6 UGT1A10 CYP1A2 SULT2A1 CYP1B1 SULT1A1 SULT1E1 CYP1A1 CYP2E1 UGT1A4 UGT2B15 CYP2C19 CYP3A4 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2C8 CYP2J2 COX5A CYP2C9 HEL-S-22 COX8A EPHX2 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 HEL-S-68p H2AX H3F3B STAT3 KHK HEL-S-30 MYL2 SNAP23 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GTPBP4 GJB6 ITGB1 CCND2 LAMA5 NCAM1 INHBA RUNX2 PDGFA SNAI1 BMP4 SHH EDAR NFKB1 PDGFRA CTNNB1 MYC LRP5 PTCH1 TP63 SMO FGFR2 FZD1 LEF1 TNLG7C CCND1 FOXI3 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis IL3RA TF GDF11 HBB KITLG EPOR EPO TNFSF6 CD79A HBG2 HBD HBG1 HBA2 HBE1 GATA1 FAS GATA2 CD34 PTPRC KIT TFRC HBZ IL3 ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MMP9 CREBBP ANGPT1 FGFR2 FLT1 FGF2 VEGFA PLCG1 SRC PIK3CA KDR PDGFRA HIF1A MAPK1 SMAD1 MAPK14 TIMP3 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 MAPK10 MAPK9 MAPK8 CRP ACLY SLC27A2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 G6PC3 PRKAG1 PRKAG2 ACACA PRKAG3 PRKAA1 G6PC2 PRKAB2 PRKAB1 ACACB G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC CUL4A ERCC5 POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 GTF2H5 CUL4B ERCC2 MNAT1 RBX1 RPA3 RPA1 ERCC1 PCNA CETN2 CDK7 POLD3 RFC1 POLD4 DDB2 POLE LIG1 POLE2 POLD2 POLE3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL5 ACSL3 CD36 FABP1 FABP9 FABP4 FABP5 DBI FABP6 SLC27A4 ACSL1 FABP2 ACSL6 FACL4 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL10 TMPRSS2 IL2 IL6 IL7 CXCL8 IL1B TNF ACE2 CCL2 IL2RA CCL3 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects GSK3B IRAK1 CAMK2A CSNK1D MAP2 ASMT SULT1A1 TRAF6 FOXO1 NFKB1 CSNK1E CYP2C19 ACHE MAOA ECE1 CALM1 ADRB1 MTNR1A CRY2 MTNR1B CRY1 APOE CYP1A2 CYP1B1 SIRT1 CYP1A1 AANAT EDN1 PRKCA PER2 PER1 PER3 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB4 MMP9 PIK3CD PLCB1 PLCB2 STAR NRAS KISS1R KISS1 BMP15 PIK3CA NFKB1 MAPK1 KRAS MAPK3 AMH MAP2K1 MAP2K2 CYP11A1 RAF1 ARRB2 FSHR HSD3B1 PRKCH PRKCB PRKCE PRKCA GDF9 PLCB3 HRAS PRKCQ THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis ADCY3 ADCY1 ADCY8 ADCY6 RPS6KA2 NRAS KDM3A HEL-S-7a KDM1A RPS6KA3 PRKG1 MAP2K3 PRKAA2 SOS2 MAPK12 KRAS MAPK13 MAP3K5 ATF2 RPTOR MAPK11 MAPK14 PRKAG1 MLST8 PRKAG2 SMARCD1 SMARCC1 ACTG1 CREB3L3 SMARCD2 RPS6KB2 PRKAG3 CREB3L4 SMARCC2 PRKAA1 SMARCD3 RPS6KA6 RPS6 LIPE PRKACG ARID1B PRKAB2 RPS6KB1 RHEB CPT1C PRKAB1 AKT1S1 ADCY9 ACSL1 ACSL6 FACL4 CPT2 ACSL5 ACSL3 TSC2 TSC1 ACTL6B SIRT6 SLC25A29 ADRB3 BMP8A BMP8B ACTL6A ZNF516 PLIN1 MGLL KDM3B UCP1 PRDM16 CPT1A GNAS FGF21 MTOR PNPLA2 SLC25A20 GCG SMARCA4 ARID1A PPARG FGFR1 PS1TP5BP1 RPS6KA1 CREB3L2 CREB3 CREB1 FRS2 PPARGC1A CREB5 CNR1 DPF1 HRAS DPF3 GRB2 SMARCE1 SOS1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy LPIN1 LPIN2 LPIN3 ITGB4 BSCL2 CAVIN1 INS PIK3CA HMFN0839 DGAT1 HIF1A IRS1 FYN GRB2 DGAT2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation RORA KLF4 CEBPA CEBPB TLE3 EGR2 FOXO1 KLF5 CEBPD INS GATA3 GATA2 EVI1 KLF15 KLF2 DDIT3 NR2F2 CTNNA1 ZNF423 RARA PPARG WNT10B NR3C1 IRF4 TCF7L1 CREB1 NR1H3 STAT5B IRF3 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PLCB4 MYL3 ADCY3 ADCY1 PLCB1 ADCY8 PLCB2 ADCY6 MYL1 NR3C1 ADRB2 MYL4 PLCB3 CREB1 ADCY9 PRKAR1B PRKAR1A MYL2 GNAS STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 STAR HSD3B1 CYP17A1 HSD17B1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COL1A1 MBTPS1 PPIB PLOD2 MIA3 LRP5 TMEM38B COLGALT1 MBTPS2 IFITM5 LRP6 CRTAP P3H2 P3H1 COL1A2 PLOD1 ADAMTS2 LOX P4HA1 BMP1 TNFSF11 FZD1 SP7 TNFRSF11B P4HA2 TNFRSF11A WNT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS5 CERS1 CERS2 tmp_locus_29 B4GALNT1 B4GALT1 CERS3 CERS6 CERK SGMS1 SPHK1 B3GNT5 SGMS2 A3GALT2 DGAT1 UGT8 UGCG SPTLC1 A4GALT KDSR MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B FGFR2 AXIN1 MAP3K1 ROCK1 FRAT1 CTNNB1 FOXL2 MAPK1 ARHA WNT4 SRY MAPK11 GADD45G FGF9 SOX9 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling NOD2 IL2RG TGFB1 HLA-DMA IL10 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL4 IL5 IFNG TNF MAF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IF2B1 TLR4 RORC STAT1 STAT3 STAT4 IL12RB1 IL12B TYK2 IFNG IL23A IL17F CSF2 TNF STAT5B IL17A ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA2 MAPKAP1 SHC1 PDPK1 CYP3A4 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 RPTOR SHC3 PRKAG1 MLST8 PRKAG2 SLC2A4 EIF4E RPS6KB2 PRKAG3 CBLC RPS6KA4 RPS6KA6 GYS1 RPS6KA5 PRKAB2 MAP3K8 RPS6KB1 MAP3K6 RHEB MAP3K7 PRKAB1 SREBF2 PIK3R3 G6PC1 MAP3K12 HEL-S-31 FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 EXOC7 MAP4K3 MAP3K2 HEL-S-42 ABCG8 ABCG5 SCD CYP7A1 PIK3R4 SESN3 PIK3R2 PIK3R1 TRIP10 RAPGEF1 MAP3K13 GSK3A HRAS INSR MAP3K1 FOXO1 INS RPS6KA3 IRS1 MAP2K3 RXRA IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 MLXIPL FASN PRKAA1 LPL CYP2B6 ANGPTL8 NR1H3 THRA GSK3B PIK3CD MAP2K5 SLC16A2 CRK SLCO1C1 PIK3CA MAPK7 NR1A2 MAP3K14 MTOR PCK1 FOXO3A PIK3C2G PIK3C2A FBP1 CBL RPS6KA1 MAPK6 MAPK4 RICTOR SOS1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape MCM5 MCM6 CAMK2A IFT46 CREBBP IFT70B HDAC2 WDR26 RANBP9 RMND5A RAB14 XPNPEP3 MKLN1 GID4 CTBP2 DYNC2I2 NEFL TFAP2B DYNLT1 DYNLT3 DYNLL2 NDUFA5 DYNLT2B RB1 MCM10 MYL6 DYNC1H1 DYNLRB2 EXOSC4 DNCL1 EXOC8 TBC1D4 EXOC7 YAP1 EXOC4 EXOC3 EXOC6 IFT172 MSH2 EXOC5 EXOC2 DOCK5 EXOC1 IFT74 PSMD7 TFAP2C SNAP29 DGKE UBE2D2 MCM2 SMC4 APMAP IFT81 TIPRL ERF ARL8B INTU USH1C CEP97 DDX5 HEL-S-296 IFT27 CDH23 NUP88 IFT25 AAR2 PSMD12 CTSA UBE2H TFAP2D HEL-S-91n TFAP2E PSMD13 RHBDD2 EXOC6B CNOT10 GDI1 LSM4 EHD3 CNOT1 WNK1 LCN2 RANBP10 RAC1 UQCC GLB1 ZMYND19 MYL6B RPGR TMED1 GLA DFNB31 NINL RBM14 PSMC6 NUDC ECHS1 PSMC4 CNOT6L NUP133 EIPR1 RAB3IL1 HEL113 ARFGAP3 RABEP2 CD2BP2 NME8 MAPRE2 CEP170 CCDC40 IFT70A ANKS3 VPS4A RAB21 RQCD1 RMND5B WEE1 DNPEP PGRMC2 VAPB BBIP1 GID8 CTNNB1 NEF3 YPEL5 DCAF7 TFAP2A HDAC1 MFAP1 PAFAH1B1 POM121 EIF5B TRAF3IP1 DVL3 RAB8A IFT52 BBS9 BBS7 IFT57 SNRPB2 BBS5 CEP290 IQGAP3 ACSL3 BBS4 IQCB1 IFT140 IFT80 LZTFL1 IFT43 MCM9 HEL-S-47e CBS NFKB1 EFHC2 STOM DYNC1LI1 APC BBS2 NEK8 BBS1 CALM1 MAEA ARMC8 FUZ TTC8 IQGAP1 MKS1 CLUAP1 COPS7A COPS4 IFT20 COPS6 IFT22 SSNA1 COPS5 COPS8 RALB CDR2 H3F3B NDUFA9 HTRA2 IFT56 MCM7 LRPPRC MCM3 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis OXCT1 ACAT1 HMGCL BDH1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members GSK3B PIK3CD TSC2 TSC1 MAPKAP1 IKBKG FOXO1 PIK3CA PARP3 AKT3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 MLST8 PARP2 PIK3R5 PARP1 PHLPP1 PIK3C2G PIK3C2A SIRT1 PIK3C2B ATM PIK3R3 RICTOR STK11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC2 TSC1 PRR5 MAPKAP1 HMGCR RRAGB RRAGD DDIT4L PRKAA2 EIF4EBP1 FKBP1A RPTOR ULK2 MTOR ULK1 PRKAG1 MLST8 PRKAG2 CDC42 PRKAG3 PRKAA1 RRAGA DDIT4 PRKAB2 RPS6KB1 IDI1 RHEB PRKAB1 AKT1S1 PRKCA RAC1 RICTOR EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host TLR4 ITGB1 IRF7 CREBBP EP300 CAV3 NEDD4 VAV2 SOCS3 HLA-B HLA-F HLA-G HLA-E HLA-DRA FLNA VPS11 VPS39 VPS16 AXL IKBKE VPS18 CLEC4M VPS33A ITGB3 ICAM2 RFC1 VPS41 PIK3R3 C1QBP MBL2 ITGA1 ITGA2 SCIN ITGA4 HLA-DRB5 HLA-DMA RAB7A TYRO3 HAVCR2 HLA-A IL4 CLTB CTSL HLA-C ACTN1 ACTN4 PIK3R2 PIK3R1 EIF2AK2 RAC1 MERTK IRF3 HLA-DQA2 HLA-DQA1 EGFR PAK1 RELA STAT1 VPS4A IGF1R HLA-DRB1 MFGE8 CLEC10A ICAM3 MAPK1 HLA-DOA HLA-DOB MAPK3 KPNA1 BST2 CD300A TFAP2A TIMD4 TSG101 CLEC6A RAB5A ASGR1 CD209 HAVCR1 ADAM17 HLA-DPA1 HLA-DQB2 RAB9A HLA-DQB1 ACTG1 HLA-DMB DAB2IP HLA-DPB1 FOLR1 NFKB2 NPC1 REL TIAM1 EIF2S1 RASA2 PIK3CD RELB TBK1 PIK3CA NFKB1 CAV2 ARHA RIGI CLTC CDC42 FLNB CLTA PRKRA IQGAP1 RHOB PS1TP5BP1 ITGAV CLTCL1 ITGA6 NPC2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAPK8 STAT3 MYEF2 JUN PRKCB EDN1 PRKCE FOS MAP2K3 GATA4 PPP3CA MAPK1 ARHA RAC1 CTF1 CAMK2D MAPK11 MAPK14 NFATC4 IL6ST FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 CPT2 ACSL5 ACSL3 ACAT1 ACADM DLD HEL-S-49 CPT1A ACADVL LIPC ACADL PNPLA2 SLC25A20 ACADS CHKB HADHB LPL GCDH LIPF LIPE CRAT ACSS2 GPD2 DECR1 ACSL1 ACSL6 FACL4 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling MEF2C MEF2B ITGB1 CDKN2A KLF4 MEF2D SRC LAMTOR3 SHC1 EIF4EBP1 HDAC7 FYN PTPN11 NFKBIA RHOD ELAVL1 CDKN1B RPS6 RPS6KB1 PXN TCF4 PIK3R3 CCND1 CD44 MAPK9 MAPK8 STAT3 KAT5 IL2 CXCL8 PIK3R2 PIK3R1 MMP7 TJP1 IKBKB RAC1 EGR1 HRAS SERPINB2 BIRC5 EGFR PAK1 PTGS2 RELA SLC9A3 VEGFA FOXO1 CTNNB1 CLDN1 MYC IRS1 MAPK1 KRAS MAPK3 ATF2 MAP2K1 MAPK14 MAP3K11 BCL2L1 RAF1 ARHGEF28 GAS PRKCH TFF2 PRKCE PRKCA KIT PRKD2 PRKCQ PRKD1 BMP2 GSK3B CASP3 CHUK CRK PLCG1 BIRC2 ROCK1 BIRC3 JUN PIK3CA NFKB1 SP1 ARHA HDC BAD MTOR CDC42 ANXA2 YES1 CCKBR ARRB2 PPARG FOXO3A RHOB FOS CDKN1A CREB1 GRB2 SOS1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 DNAJB1 CRTC2 CREB1 SIK1 HDAC7 GNAS SIK3 SIK2 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 CD68 LYZ CD163 F3 CD14 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer GSK3B RB1CC1 TSC2 MAPKAP1 TFEB NRAS FOXO1 PIK3CA EIF4EBP1 KRAS BAD RPTOR MTOR ULK1 PIK3R2 PIK3R1 MLST8 CDKN1B FOXO4 FOXO3A GRB10 RHEB PIK3R3 PTEN RICTOR HRAS GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CCK VIP SCT PGA3 PGC PGA5 MUC6 GAS CBLIF MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3CD PLCG2 NCKAP1L VAV1 VAV2 TREM2 PIK3CA TREM1 LAT LYN PIK3R2 SYK PTPN6 PIK3R1 CYBB ITGAM NCF2 C1QB C1QA PIK3C2A RAC3 NCF1 NCF4 FCER1G VAV3 PIK3R3 FCGR1A CYBA RAC1 ARPC1B SIGLEC7 TYROBP C1QC MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 STK11 CTDSP1 STRADB GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P PFKP HEL-S-30 PPM2C 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 TRAF2 ATG16L1 ATG101 GABARAPL1 GABARAP RB1 TNF PTK2B MAP3K5 ULK1 WDR45B TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NR1D1 SMAD2 STAT1 TGFBR1 ZAP70 TYK2 GATA3 IL27 SOCS3 RXRA MAPK1 LAT MAPK14 NFKBIA CRY1 RARA RUNX1 IRF4 NFIL3 IL6R IFNG HIF1A IL23A IL17F AHR PRKCQ LCK PER1 IL17A IL27RA IL2RA IF2B1 IL23R RORC RORA MAPK8 CD3G IL-21 TGFB1 CD3E HLA-DMA STAT3 CD3D TBX21 IL21R PLCG1 IFNGR1 JUN NFATC1 FOXP3 NFKB1 IL2 IL4 IL6 MTOR FOS IKBKB PPP3CA IL1B JAK1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RBP3 RDH11 RDH8 RHO RBP1 RDH5 OPN1LW RLBP1 RPE65 RDH10 OPN1MW RDH12 OPN1SW LRAT ABCA4 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCB4 PI4K2B PIK3CD PLCD3 TPTE2 PLCB1 PLCD4 IPMK PLCB2 FIG4 PI4KB PIP4K2A PLCG2 PLCG1 PIK3CA INPP5D PI4K2A INPP5E PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR8 INPP4A STM7 INPP4B PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SACM1L OCRL PIKFYVE MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 FST FGFR2 RBFOX2 CBX2 SOX8 EMX2 AMHR2 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 INSL3 WT1 WNT4 SRY MAPK11 RSPO1 AMH FGF9 SOX9 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 FIS1 MIB1 OPA1 BAX MTFP1 MFN2 BNIP3 MFN1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 PFKM HEL-S-68p PGAM2 HEL-S-133P GPT HEL-S-49 HEL-S-30 HEL-S-87p HEL-S-162eP FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 ORAI1 KL DMP1 CYP24A1 FGFR2 ALPL FAM20C SLC34A1 ROS1 GALNT3 PTH ENPP1 NFKB1 CDKN1A NFKB2 CYP27B1 SPP1 CCND1 CYP11B2 FGF23 FGFR3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling ADCY3 ADCY1 ADCY8 ADCY6 STAT2 GNG3 GNG2 GNG5 CCR2 GNG4 GNG7 VAV1 GNG8 VAV2 CCL11 SHC1 c-fgr CX3CL1 CCL5 CCL19 CCL7 SOS2 CCL28 SHC4 SHC2 CCL4 SHC3 NFKBIA CCL1 NFKBIB CCL15 CXCR4 CXCR6 PRKACG PXN PIK3R3 STAT5B PTK2B CCR10 JAK3 CCR1 XCR1 GNAI1 CXCL12 STAT3 WAS CCR8 GNAI3 CCR4 RAP1A CRKL CCR3 LYN PIK3R2 PIK3R1 IKBKB RAC1 HRAS CXCL13 CXCL11 CXCL14 CCR6 PLCB4 PLCB1 PLCB2 PAK1 RELA STAT1 BRAF NRAS ADRBK1 PPBP CX3CR1 CXCL3 AKT3 MAPK1 KRAS XCL1 MAPK3 MAP2K1 CCL17 CCL20 CCL25 CCL24 CCL22 RAF1 CCL21 CCL27 PF4 CCL26 NCF1 PRKCB GNG10 CCR7 CXCR5 GNGT2 ADCY9 TIAM1 PARD3 GSK3B PIK3CD PRKCZ GRK5 CHUK GRK4 WASL PREX1 CRK ELMO1 IKBKG ROCK1 GRK1 ROCK2 DOCK2 GNG12 PRKX GNG11 PIK3CA NFKB1 GNG13 GNB2 GNB1 ITK GNB4 CXCL5 GNB3 GNB5 CDC42 PIK3R5 ARRB2 FOXO3A GNGT1 CXCL16 VAV3 IL8RB PLCB3 CXCL9 CXCR3 CSK GRB2 SOS1 CCL3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 CYFIP1 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP9 EGFR SMAD2 COL1A1 SMAD4 FLT1 RELA TGFBR3 RELB CHD2 CTGF SNAI1 VEGFA SNAI2 TGFBR1 NRP1 SRC KDR NFKB1 PLXNA2 HGF AKT3 PLXNA1 PLXNA4 CDK2 MAPK1 MAPK3 MET COL1A2 MAP2K1 MAP2K2 SEMA3A EGF CDKN1B CCNE1 GSK3A CCNE2 PECAM1 NFKB2 MMP2 RAC1 REL TGFBR2 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CDKN2A DOCK1 HGF EIF4EBP1 RPTOR PTPN11 CDKN1B HSD3B1 HSD17B3 ETV4 HSD17B7 CYP17A1 RHEB PXN RB1 PTK2B CDC2 CCND1 CHEK2 CHEK1 MAP4K1 TSC2 MAPK8 TSC1 STAT3 BAX CDC25B MSH6 MSH2 BLM ACTL6A CPN1 RAP1A KLK3 BARD1 CASP8 CRKL HSD17B4 HSD17B1 HSD3B2 PLK1 RAPGEF1 SMARCA4 ARID1A F13B NOXA1 MDM2 ATM ATR PTEN BRCA1 JAK1 HRAS ERG SMAD2 PAK1 STAT1 MRE11A RAD50 CDK4 MYC CDK2 MAPK1 MAPK3 ATF1 MAP2K1 MAPK14 MAP2K2 FOXA1 BCL2 SMARCD1 SMARCC1 RAF1 SMARCD2 SMARCC2 SMARCD3 ARID1B FKBP5 HSD17B2 CDKN2B SPRY2 CASP9 CASP3 ACTL6B CRK EIF4E1B JUN PIK3CA SP1 SPRY1 SPINK1 BAD MTOR PRKDC FOS CDKN1A RICTOR GRB2 SOS1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR FASN PRKAA1 SIRT1 HMGCR ABCA1 SIRT6 SREBF2 HMGCS1 NR1C1 NR1H3 PPARGC1A MED15 SCD MTOR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK1 IRAK2 MAPK8 MYD88 TGFB1 RELA CHUK TRAF6 MAP3K1 MAP3K7IP1 JUN NFKB1 IL6 MAP2K3 TNF MAP3K14 MAP2K6 MAPK14 NFKBIA IRAK3 ECSIT MAP3K7 IFNB1 IL1R1 IKBKB IL1B IL1RN IFNA1 IL1A FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR3 S1PR4 S1PR5 HEL-S-171mP MS4A1 S1PR1 BTK EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3 NR1D2 G0S2 PSMA4 KLF9 HLA-DMA HEL-S-22 CEBPB PPP1R3C DAZAP2 BTG1 TOB1 STBD1 CLDN5 SUMO3 ERC2 RBPMS CRY2 ZFR ETV6 AAG1 CRY1 HEL-S-72p MYF6 SUMO1 UCP3 IDI1 NCKAP1 GSTM3 PIGF PURA QK3 PER2 H2BC15 PER1 VAPA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 IKBKE IFNB1 MAVS TRAF3 RIGI TRAF6 TBK1 IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CDH17 SCEL PLA2G10 SPRR1B TSPAN8 FAM83A CYP3A7 DHRS9 TNS4 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 KRT20 LGALS4 VSIG2 S100A2 AGR2 AGR3 TFF2 CST6 FAM3D REG4 KRT6C SERPINB3 BTNL8 KRT7 GPR87 ANXA10 LYZ LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 AREG KRT6A FGFBP1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IRAK1 NLRP3 MMP9 PLA2G7 MYD88 HEL-S-134P TLR1 PIK3CA FCER1A NFKB1 F2 S100A9 IL18 IL1R1 IFNG HBEGF IL1B CCL2 F2R CCR3 TIMP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R2 PPP4R4 PARP4 HEL-S-69 ASPHD1 TCP1 KCTD13 ZG16 INO80E MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 MAP2K3 MAPK3 MAP2K6 TBX6 CCDC6 PPP2R1A PAXIP1 KMT2C NR3C1 PAGR1 SMEK1 REL PPP2CA EZR SPN PRRT2 PPP4R3B TRAF2 TRAF6 NFKB1 CASP8 BPTF HEL-S-87p PCNA CCT7 TAOK2 PPARG MLL2 HEL70 PPP2R5D PTEN UNC13B UNC13A HEL-S-90n CCT6B HDAC3 SIAH1 DOC2A FAM57B FIMP CDIPT PPP4R1 CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-29 HEL-S-20 NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B YES1 NFE2L2 MAPK8 INSR NQO1 CEBPB EPHB2 SRC PIK3CA SLC7A11 HMOX1 PRKCA RBX1 PGAM5 FYN MAF GCLM AIMP2 KEAP1 GCLC CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways CAMK2A ADCY3 CDKN2A ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CAMK2G PDGFRA HGF SOS2 MET TGFA BCL2L11 EGF RPS6KB2 TPM3 FGFR2 NR1C2 PIK3R3 SUFU HIF1A PTCH2 KIF7 STAT5B IL2RG CXCL12 CALML6 ARAF CALML3 FZD10 STAT4 CALML4 IL12RB1 FRAT1 FRAT2 IFNGR1 IL13 EVI1 IL2 IL4 IL5 CXCL8 IL5RA KLK3 CSF2RB CRKL PIK3R2 PIK3R1 IL3 IL3RA EDNRB MGST1 FADD GSTT2 FZD1 WNT10B WNT10A NQO1 FZD3 TXNRD2 FZD2 FZD5 FZD7 FZD9 FZD8 GNA13 IKBKB HRAS APC2 PLCB4 IFNA13 IFNA14 PLCB1 IFNA16 PLCB2 IFNA17 IFNA10 PTGS2 RELA IFNA21 FGFR4 IF1AA9 NRAS BMP4 SHH WNT7B WNT7A FAS CTNNB1 IFNA8 IL7 BDKRB2 MAP2K1 MAP2K2 WNT5B GSTM2 RAF1 TNFSF6 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A RET CYCS GSK3B WNT2B PIK3CD CASP9 CASP3 CHUK APAF1 AXIN1 TRAF2 TRAF6 CRK ROCK1 ROCK2 AXIN2 WNT16 PIK3CA LRP5 ARHA LRP6 NOS2 BAD MTOR APC CDK6 JAG2 E2F3 FZD4 PPARG FGFR1 GLI3 HEY2 CBL WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 PTGER4 IFNA1 GRB2 PTGER2 SOS1 GSTT2B FGFR3 CCND2 TFG EML4 NKX3-1 PLEKHG5 IL15RA ARHGEF11 CDKN1B BBC3 SPI1 IGF2 CCND3 IL12B DDB2 IL12A IL6R CCNE2 IFNG IL23A PMAIP1 GADD45B GADD45G ARHGEF12 PTGER1 PTGER3 GNAI1 BAX PTCH1 SMO SMAD2 SMAD4 RXRA BCL2 NFE2L2 HDAC1 GNA11 NTRK1 ARNT2 EGLN1 EGLN3 RASGRP4 EGLN2 CDKN2B ELOC HMOX1 EDNRA F2R RALBP1 CTBP1 PLD2 SKP2 ARHGEF1 RALB APPL1 CREBBP HDAC2 EP300 CEBPA CTBP2 FLT3 ZBTB16 RARA RUNX1T1 PRKACG RPS6KB1 CCNA2 RB1 JAK3 CCND1 IL2RA IL2RB IL15 MSH6 MSH2 MAX RASGRP3 TPR VHL GADD45A F2RL3 MDM2 MGST3 MGST2 GSTM3 PTEN BRCA2 GSTM5 MMP2 RAC1 MMP3 JAK1 TGFBR2 NCOA1 RALA EGFR FLT3LG BAK1 STAT1 PML DCC MSH3 VEGFA RAD51 HEL-S-125m BCL2L1 GSTA5 GSTA4 KPG_010 RUNX1 GSTA3 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 F2 GNGT2 NFKB2 KIT VEGFB VEGFC HHIP VEGFD POLK KITLG HEL-S-22 CSF3R EPO IFNAR2 BIRC2 COL4A2 BIRC3 COL4A1 COL4A4 COL4A6 IFNAR1 CSF1R TXNRD3 IL7R HSP90AB1 FLT4 LAMC2 ITGAV CDKN1A ITGA6 LAMA1 LAMA4 LAMA3 ITGB1 LAMB3 LAMB2 STAT2 EPOR ALK ERBB2 NFKBIA CTNNA1 CTNNA3 CTNNA2 CXCR4 RPS6KA5 ITGA2B RAC3 E2F2 IFNA6 IFNGR2 LAMC1 FH CKS1B ITGA2 TRAF1 TRAF4 COL4A3 TRAF5 RARB COL4A5 BIRC7 MAPK10 RXRB RXRG LAMA5 MAPK9 MAPK8 LAMB4 TGFB1 STAT3 CCDC42 GNAI3 JUP CASP8 BDKRB1 LAMB1 KNG1 CCNE1 EDN1 BIRC5 CSF2RA TRAF3 PDGFA GSTM1 BRAF IGF1 TGFBR1 FOXO1 IGF1R RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 NR3A2 AGTR1 IL6ST NOTCH2 NOTCH3 CCDC6 NOTCH1 LEF1 PRKCB HES1 HES5 PRKCA TCF7L2 TERT TCF7L1 ADCY9 GSTM4 BMP2 KEAP1 LPAR1 PLCG2 PLCG1 IKBKG JUN SKP1 PAX8 GNG12 GNG11 NFKB1 GNG13 RBX1 IL6 SP1 GNB2 GNB1 IFNA2 GNAS GNB4 BCR GNB3 GNB5 PIM1 PIM2 GNGT1 HEL-S-21 FOS IL13RA1 PLCB3 DAPK2 CAMK2D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 LEP LPIN1 MAPK8 PPARG INSR NR3C1 CEBPA CEBPB FOXO1 CEBPD IL6 IRS1 RXRA CREB1 TWIST1 PPARGC1A TNF PCK2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 CREB3L3 CREB3L4 RELA RELB IL10 CREB3L2 NFKB1 CREB3 NFKB2 IL6 CREB1 IL1B MAPK12 REL CREB5 MAPK13 CCL2 MAPK11 MAPK14 CD14 ATF4 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CDC45 MRE11A PML FOXM1 SMARCAL1 RAD50 RAD51 CDK2 DCLRE1A RPA1 UBE2D3 HUS1 FANCD2 HERC2 TOPBP1 CLK2 RECQL EEF1E1 CLSPN TDP1 H2AX SMARCC2 FEN1 NBN SMC1A RNF8 CEP164 ATRIP SHFM1 CDC2 RAD52 CHEK2 RAD17 RAD1 CHEK1 RAD9A XPA PPM1D RBBP8 BCL6 MDC1 IKBKG TRIM28 MSH2 BRIP1 TP53BP1 MCPH1 RECQL4 WRN SP1 FANCA BARD1 UIMC1 PALB2 RFWD3 PLK1 PCNA PRKDC MCM2 PARP1 ABRAXAS1 BRCC3 MDM2 ATM ATR BRCA1 POLN BRCA2 RMI1 USP1 TOP3A XRCC5 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 ACADS ACSL3 SLC22A5 ACADM HADHB PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 SRD5A2 CYP21A2 AKR1D1 AKR1C1 HSD3B1 CYP17A1 HSD3B2 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma CDKN2A EZH2 KIF23 KDR PDGFRA HGF CTBP2 PRKAA2 MET RPTOR CCL4 TGFA DEPTOR PRKAG1 MLST8 PDGFC PRKAG2 FLT3 EIF4B EGF WIF1 RPS6KB2 PRKAG3 FGFR2 RPS6 PRKAB2 RPS6KB1 RHEB PRKAB1 AKT1S1 HIF1A LIMD1 MCL1 CCND1 TNNT1 ITGA4 NF2 TSC2 TSC1 CXCL12 YAP1 FABP4 FZD10 ROR2 FRAT1 FRAT2 IL10 CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E MAX DKK1 DKK2 DKK4 SFRP4 DDIT3 BARD1 CSNK2B STK38L TNIK ULK2 ULK1 FOSL1 FZD1 CDK7 WNT10B WNT10A FZD3 MDM2 ATM FZD2 FZD5 FZD7 FZD9 UHRF1 FZD8 PTEN BRCA1 LATS1 TEAD4 MMP2 LATS2 MMP3 JAK1 HRAS TEAD2 TEAD3 MMP14 PLCB4 EGFR NTF4 FLT3LG PAK1 BAK1 STAT1 FGFR4 MAP3K1 VEGFA CSNK1A1 WNT7B SFRP1 SLC7A5 WNT7A CTNNB1 FGF10 HMGB1 RPS6KA3 CSF1 HBEGF MAP2K3 MAP2K4 CHD8 MAP2K6 MAP3K5 MAP2K1 MAPK14 MAP2K2 MAP3K10 WNT5B MAP3K11 RAF1 KMT2C EPHA2 AGER ASXL1 WDR5 BAP1 DVL1 FGF8A DVL2 DVL3 KIT WNT1 WNT3 WNT4 RBBP4 FGF6B WNT3A VEGFB MAPKAPK2 CYCS VEGFC MCU VEGFD GSK3B WNT2B PIK3CD WWC1 MAP2K5 NGFR SOX17 KITLG RB1CC1 CER1 CSF3 AXIN1 TRAF2 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA MAPK7 CSF1R NTRK2 LRP5 EFNA5 EFNA4 LRP6 FGF20 FGF22 FGF7 FGF21 CXCL5 FGF8 EFNA1 MTOR FGF9 APC EFNA3 FGF14 CSNK1A1L EFNA2 FGF13 FGF18 FGF12 FGFR1 ITGB4 FLT4 LAMC2 AMOT FGF2 FGF7B ITGAV FGF7A RASSF7 CDKN1A NGF ITGA6 FGF5C LAMA1 LAMA4 LAMA3 GRB2 CXCL1 AREG SOS1 FGFR3 NLRP3 ANGPT4 IDO1 MMP9 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 LAMB2 MEF2D BDNF SRC SHC1 SETD2 CCL5 EIF4EBP1 CCL2 MOB1A CTNNA1 CTNNA3 CTNNA2 RASSF2 RASSF3 RASSF4 BBC3 RASSF6 ITGB3 RPS6KA5 HCFC1 IGF2 PHC1 CCND3 PRSS23 IL34 MAD2L1 MAP3K6 DSC3 LAMC1 BAG2 MDK RNF2 CTHRC1 MOBKL1A ITGA1 PAK6 CDH9 CDH8 PAK4 CDH4 ITGA2 CDH10 COL4A3 CDH11 CDH12 HEL-S-31 CDH15 AJUBA COL4A5 CDH17 VGLL4 ACTA2 CIT CD44 MAPK10 CDH19 MAP4K1 CDH24 LAMA5 MAPK9 WWTR1 MAP4K2 MAPK8 SPARC MINK1 TGFB1 LIN28B BAX MAP4K3 CTGF MAP3K2 EED LAMB1 SELE TTI1 MDM4 LGALS9 SUZ12 HMGN1 CCNE1 PPARGC1A CSF2 BMI1 FGF23 FLT1 PRB1 INSR PRB2 CDH6 PDGFA CDH2 IGF1 CD47 OGT FOXM1 CDH16 FOXO1 IGF1R INS RASSF1 CDK4 MYC AKT3 CDK2 YY1 MAPK1 RYK MAPK3 ROR1 ATF2 PDGFD BCL2 ACTG1 EIF4G1 PRKAA1 SOST LEF1 NTRK1 TCF7L2 TERT NTF3 TCF7L1 PIGF KREMEN1 SENP2 SFRP5 ATF3 CXXC4 PORCN NOTUM SLC3A2 BTRC JUN NFKB1 IL6 SP1 SETD5 CTBP1 PS1TP5BP1 HEL-S-1 RPS6KA1 BTC GABPA SETDB1 CDH18 MAD1L1 ACTA1 CREB1 IL1B ACTG2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling TLR4 IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 TRAF3 LY96 IFNA21 IF1AA9 TIRAP MAP3K7IP1 IFNA8 AKT3 MAP2K3 CCL5 MAP2K4 MAPK1 TNF MAPK12 MAPK3 MAP2K6 MAPK13 CCL4 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B IFNA7 MAP3K7 RIPK1 IL12A TICAM1 IRAK1 IRAK4 MAPK10 MAPK9 TAB3 MAPK8 MYD88 CHUK LBP TRAF6 TBK1 IFNAR2 IKBKG JUN IFNAR1 NFKB1 IL6 TLR5 CXCL8 CASP8 SPP1 IFNA2 TLR9 TLR7 FADD FOS IFNB1 IKBKB IL1B RAC1 CXCL9 IFNA1 CXCL11 IRF3 TLR8 CD14 TLR3 CCL3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2 EPHX2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway KIR2DL1 KIR2DL3 VAV1 PLCG1 PRKCA LCP2 IFNG CD34 CSF2 HLA-C TNF RAC1 FYN HRAS LAT TYROBP PRKCQ GRB2 SYK PTPN6 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX H2AB1 H3C8 SUZ12 BCL6 H2AZ1 EZH2 H2AZ2 RNF2 H3C15 H2AB3 PCGF1 H3F3B MAPK1 H2AJ MAPK3 EED MACROH2A1 BCOR MACROH2A2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH COQ6 COQ2 SLC52A1 PDSS1 ETFA COQ8A FLAD1 COQ9 APTX COQ7 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMB3 LAMA5 LAMB2 SRC SHC1 IRS1 EIF4EBP1 MAPK1 ARHA MAPK3 PTPN11 MAPK14 MTOR PIK3R2 PIK3R1 LAMB1 ITGB4 LAMC2 LAMC1 PRKCA ITGA6 RAC1 LAMA1 HRAS LAMA3 GRB2 SOS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HEL-68 HCLS1 TLR4 KRT18 TUBA2 ITGB1 ARPC2 ARPC3 TUBA8 LY96 WASL ROCK1 WAS ROCK2 TUBB8 TUBA1C CTNNB1 CLDN1 TUBB6 TUBA1B TLR5 TUBA1A ARHA FYN TUBB1 ARHGEF2 CDC42 TUBB ACTG1 TUBA4A YWHAQ TUBB2A PS1TP5BP1 NCL NCK2 TUBAL3 NCK1 YWHAZ PRKCA TUBA3E ARPC5 ARPC1B TUBB4B EZR CD14 TUBB4A ARPC4 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 MTARC2 MOCS1 XDH GPHN AOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds GSK3B FZD1 MBOAT1 DKK3 LEF1 AXIN1 CSNK1A1 FZD7 FZD8 TCF4 CTNNB1 DVL2 SFRP4 WNT1 TNKS APC CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells RGS16 CAMK2A ADCY3 ADCY1 CACNB1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G RGS10 CASQ1 RGS11 FKBP1A GJB1 ADRA1B ADRA1A GNAZ GJB6 GNAI1 GJA9 ATP1B3 STIM2 GJC1 GJB4 GJB3 GNAI3 ANXA6 GJD2 HEL-S-99n CASQ2 ATP1A4 PLN KCNJ3 KCNB1 CXNA GNAO1 ADRB1 ATP1B2 ATP1B1 CAMK1 FXYD2 CHRM1 ATP2B3 ATP2B2 ATP2B1 HEL2 GJB2 ORAI1 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 CACNA1C RGS6 RGS7 PRKCH PRKCB GNA11 PRKCE PRKCA CACNB3 CACNA1S ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ CHRM2 CHRM3 GRK5 GRK4 ADRA1D SFN ADRB3 GNG12 GJA3 GNG11 GJA5 GNG13 GJA8 PKIB CXNO PKIA GNB2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 CACNA1B RYR1 RYR2 ATP2A2 CACNA1A ARRB2 RYR3 GNGT1 KCNJ5 YWHAQ HEL-S-1 YWHAG CHRM4 CHRM5 GJA4 YWHAZ ADRB2 PLCB3 RGS18 RGS17 CAMK2D RGS14 CAMK4 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling EGFR CREBBP AGTR2 CSF2RA F2RL2 MAPKAP1 IL10RA SRC TYK2 PDGFRA SOCS3 MAPK1 PTPRC IL11RA MAPK12 MAPK3 MAPK13 CTF1 RPTOR GHR IL15RA MAPK11 MAPK14 DEPTOR AGTR1 IL6ST MLST8 IL10RB IFNGR2 PRKCB IFNLR1 AKT1S1 IL6R OSMR JAK3 IL20RA IL20RB IL27RA IL2RA IL2RB MAPK10 MAPK9 IL2RG MAPK8 STAT3 CSF3R IFNAR2 IL21R CNTFR TRIM28 IFNGR1 IFNAR1 MAPK7 PTPRT IL5RA MPL CSF2RB MAPK15 IL22RA1 F2R MTOR IL9R IL3RA IL7R SETD7 F2RL3 DUSP2 MAPK6 MAPK4 JAK1 RICTOR DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism DDC NQO1 MAOA PRKACG PPP2CA TH HEL-S-44 TYR HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC5 CD44 CASP9 SMAD4 MAPK8 PTGS2 CASP3 TGFB1 STAT3 MYOF RRM2 VEGFA COL4A2 TGFBR1 VAV2 BIRC3 JUN NFKB1 FRZB MYC IL6 CXCL8 MAPK3 NOS2 PTPN11 MAPK14 BCL2L1 HNF1A LEF1 TNFSF6 E2F2 HEL-117 IL6R CDKN1A BRCA1 HIF1A CXCR1 RAC1 JAK1 GRB2 CCND1 SOS1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders ECHS1 ACAT1 PSAT1 PSPH ENO1 HEL-S-68p GLDC AMT HEL-S-30 PHGDH HEL-S-20 SLC2A4 ETHE1 SQOR SUOX SPCS1 CDO1 GCDH HEL-S-51e LDHB MPC1 HEL-S-133P GPT HK3 DHTKD1 G6PC1 HEL-S-32 GCK SLC25A15 ASL MOCS2 MOCS1 SFXN1 GPHN ARG1 HEL-S-162eP CBS PFKL SLC25A1 ENO2 PFKM ENO3 SLC25A5 MPC2 PGAM2 ALDH7A1 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-87p CTH MOCS3 HK2 AASS SLC7A2 HEL60 PCK1 PDHA1 MDH2 GOT2 PKLR ASS1 XDH GLUD1 ALDOB SHMT1 FBP1 PC SLC2A3 BTD HLCS SLC2A2 OTC GLS2 AADAT DLAT MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes AP3D1 ARHG ARCN1 WDR11 CEBPB PPIB LAMTOR3 PLXND1 TUSC2 ARID4B HEL-S-30 VPS39 FADS1 TNLG5A TPM3 GYS1 RAB34 MAP3K8 ANAPC1 TMED10 RAB5C ADIPOR2 SLC1A4 CORO1C SAC3D1 MCL1 MPDU1 CD164 SNAP23 BRPF3 HMGA1 CAP1 TBCA IGF2R BCL6 MENT SLC25A1 ADPGK THBS1 TNFAIP2 ADAR LMNB2 TUBA1A TMEM109 ACP2 PRSS21 SCYL1 TXN2 RFT1 DDX5 UNC93B1 GNA13 DNAJB1 POLR2C SPTLC1 ATP6V1F CDIPT ATP6V0E1 POLE4 FMNL2 SERPINE2 CTNNB1 DCAF7 PNP CHORDC1 MAPK14 GOLGA7 CDK5RAP3 BCL2 PPIF IFRD1 LPL PISD MTHFD2 TYMS RTN4 POM121 MRPL20 SLC7A11 RDH10 KCNN4 SNX6 PHC2 SFXN1 HEL-S-26 HEL-S-47e ARF4 TRAM1 HMOX1 MRC2 TMEM43 TMED3 SH3BGRL3 CTSC CDK6 ANXA2 ATP2A2 PRPF40A YWHAQ SLC7A6 CDCP1 FRG1 PTRH1 NELFCD HEL-S-66 PTPA USP1 CA12 SHOC2 SRSF10 APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis BIRC5 IRF7 CDKN2A BAK1 RELA TRAF3 CASP10 MAP3K1 IGF1 IGF1R FAS LTA MYC MAP2K4 TNF NFKBIA IRF6 BCL2L11 TP63 NFKBIB BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO IGF2 TNFSF6 CASP6 IRF4 RIPK1 IRF1 PMAIP1 TRAF1 TNFRSF10B MCL1 CYCS MAPK10 BNIP3L CASP9 CASP3 TP73 CHUK APAF1 BAX TRAF2 HRK IKBKG BIRC2 PRF1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 TNFRSF25 CASP8 CRADD BAD SCAF11 PIK3R1 BCL2L2 IRF2 FADD HELLS MDM2 TNFRSF21 TRADD IKBKB TNFRSF1B IRF3 NFKBIE OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F8 CYP2C8 CYP2J2 CYP4F11 CYP46A1 CYP26A1 CYP2S1 CYP27C1 CYB5R3 CYP7B1 CYP26B1 CYP4V2 CYP27B1 CYP2C19 CYP3A7 CYP3A4 CYP2W1 CYP11B2 CYP27A1 CYP2R1 CYP3A43 CYP2A7 CYP8B1 CYP26C1 CYP2C9 CYP2A6 CYP2B6 CYP17A1 CYP2A13 CYP4A22 CYP2F1 CYP4B1 CYP20A1 CYP4F2 CYP4A11 CYP4F12 POR CYP51A1 CYP24A1 CYP7A1 CYB5R1 CYP11A1 CYB5R4 CYB5B CYP1A2 CYP1B1 CYP1A1 CYP4Z1 CYP2E1 CYP2U1 CYP4F22 CYP4X1 CYP2C18 CYP4F3 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CREBBP EP300 FGFR4 CEBPA SETD2 MYC ERBB2 KDM6B ARID4B MYB MAP2K2 NCOR1 NFIB ARID5B NOTCH1 RAF1 KMT2C TLK1 SMC1A MYBL1 CHEK2 CHEK1 PIK3CA BCORL1 MAX FGF16 PRKDC FBXW7 MAML3 SRCAP JMJD1C CTBP1 HIST1H1E ARID1A CMTR2 MAGI1 DTX4 FOXO3A HIST1H2AK INSRR FOXP2 MORF4L1 ATM KAT6A MYCBP MGA KANSL1 UHRF1 PTEN BRCA1 HRAS BCOR SMARCE1 ERBIN MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MYLK PLCB2 RCAN1 CISH MYEF2 IGF1 MAP3K7IP1 IGF1R LIF CTNNB1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 GATA4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 CTF1 MAP2K1 MAPK14 NFATC4 MAP2K2 CDK9 IL6ST EGF RAF1 IKBKE FGFR2 PRKCB DVL1 PIK3R3 WNT3A EIF2B5 GSK3B PIK3CD NPPB MAP2K5 MAPK8 TGFB1 CHUK STAT3 IKBKG ROCK1 ROCK2 PIK3CA MAPK7 NFKB1 LRP5 LRP6 ARHA MAP3K14 MTOR PIK3R2 PIK3R1 CALM1 FZD1 CDK7 FZD2 FGF2 NPPA EDN1 IKBKB PPP3CA MAPK4 RAC1 CAMK2D MYLK3 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 SLC19A3 DKFZp667O1614 HEL107 SLC19A2 OGDH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IFI6 STAT2 STAT1 IFNGR1 ISG15 SOCS3 SOCS1 HLA-B MHC2TA NOS2 IFNA2 PTPN11 TAP1 CYBB IRF2 OAS1 SPI1 IRF9 IFIT2 H4C9 IFNGR2 IRF4 EIF2AK2 IRF8 IRF1 GBP1 IFNB1 IFNG IL1B JAK1 CXCL9 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 ITGB1 CDKN2A EGFR HEL113 IGF2R STAT1 BAX IGF1 CLDN7 JUN IGF1R SRC NFKB1 CTNNB1 CLDN1 CDK4 CDK2 TLN1 PIK3R1 NOTCH1 BCL2 CDKN1B PSEN2 ABCC1 IGF2 CCNE1 MDK PRKCA PECAM1 PTEN TACSTD2 RB1 ACVRL1 RAC1 PAK4 CCND1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 LPAR1 JAG2 ALPL PLAT CALU SOX6 VEGFA GJA5 DLL3 DLL4 ITGA1 MGP FGFR3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT1 ACAT2 HMGCR GGPS1 IDI1 FDPS MVK HMGCS1 FDFT1 IDI2 PMVK MVD HMGCL FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP STAT1 SNAI1 BMP4 ATG5 MAPK1 MAPK12 IHH MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 FGF9 MAP2K2 SOX9 RAF1 FGF18 PTHLH RBL1 CDKN1A NPR2 PTH1R PPP2CA BMP2 THRA FGFR3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades TFPI C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PAK1 ZAP70 GRAP2 LCP2 CDK4 CARD11 BCL10 PTPRC TNF FYN MAPK3 NFATC2 LAT MAP2K1 NFKBIA CTLA4 MAP2K2 PTPN6 RAF1 MAP3K8 MAP3K7 CD40LG IFNG PRKCQ LCK GSK3B DAG1 MAPK9 CHUK CD3D CD8A IKBKG PLCG1 IL10 JUN PIK3CA NFKB1 IL2 IL4 IL5 RRAS MAP3K14 ITK PDCD1 ICOS CALM1 CBL NCK1 FOS IKBKB CHP1 CSF2 AHSA1 GRB2 SOS1 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP SMAD9 BMP7 ZNF423 PPARGC1B PPARG DGIC ZIC1 CEBPA CEBPB BMP4 CEBPG DKFZp781O1323 SLC7A10 PRDM16 PPARGC1A HSPB7 SMAD1 CIDEA EBF3 BMP2 HOXC9 HOXC8 MPZL2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer CDKN2A EGFR BAK1 NRAS BRAF ALK RASSF1 PDPK1 CDK4 HGF AKT3 RXRA ERBB2 MAPK1 EML4 SOS2 KRAS KIF5A MET MAPK3 HEL-S-61 MAP2K1 STK4 MAP2K2 TGFA EGF RAF1 E2F2 PRKCB DDB2 PRKCA RB1 STAT5B GADD45B JAK3 GADD45G CCND1 RET CYCS RARB PIK3CD FHIT POLK RXRB CASP9 RXRG CASP3 STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA CASP8 BAD GADD45A CDK6 E2F3 CRABP2 CRABP1 FOXO3A CDKN1A HRAS GRB2 SOS1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 RPH3A MLPH UNC13D MADD TBC1D10A SYTL2 EXPH5 RAB27A RAB27B SYTL1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MCM5 MCM6 CDKN2A CCND2 CDC45 WEE1 CDK4 MYC CDK2 RPA3 RPA1 CREB3L3 CDKN1B CREB3L4 CCND3 E2F2 CCNE2 POLE TFDP1 CDKN2D RB1 CCNB1 CDKN2B POLE2 CCNG2 CDKN2C CDC2 CCND1 PRIM2 POLA2 MYT1 CCNH CDKN1C MNAT1 GADD45A PCNA TFDP2 MCM2 CDK6 E2F3 CDK7 MDM2 CCNE1 ATM PRIM1 CREB3 CDKN1A CREB1 ORC6 ORC3 ORC2 MCM7 ORC1L MCM3 ATF6B DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 HDAC2 LAG3 STAT2 EP300 STAT1 CXCL2 TRAF3 AP1G1 NUP98 RAE1 PPBP CXCL6 IFITM1 CXCL3 CCL5 TP53I3 TNF ACE2 CCL2 CCL4 TFAP2A LARP1 MX1 CD160 PF4 IFIT2 RIPK1 IL6R hEMMPRIN TRAF5 TANK TGFB1 CXCL12 TRAF2 TRAF6 TBK1 IFNAR2 DHX58 TRIM25 IL10 HAVCR2 IFNAR1 NFKB1 IL6 CXCL8 MAVS CASP8 RIGI CXCL5 TLR7 FADD TRADD IL8RB IFNB1 CSF2 JAK1 CXCL9 CXCL17 CXCL13 CXCL11 CXCL1 IRF3 CCL3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP9 CASP3 BBC3 APAF1 TP53AIP1 BAX MDM2 ATM EI24 SHISA5 CYS1 ZMAT3 PERP DDB2 PTEN PMAIP1 SIAH1 CASP8 TNFRSF10B SESN3 CHEK2 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP LRP5 LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ECHS1 TDO2 IDO1 ACAT1 STAT1 ASMT TPH2 TPH1 AOC1 ALDH8A1 IL4I1 DLD DDC MAOA AOX1 ALDH2 GOT2 GCDH CYP1A1 KYAT3 KYAT1 AANAT INMT AADAT HAAO AHR KMO KYNU AFMID IDO2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 MAPK8 PTGS2 TSC1 PINK1 IKBKG FOXO1 PIK3CA HMOX1 NFKB1 GSX1 IPCEF1 IL6 PIP CXCL8 MAP2K3 CDK2 MAP2K4 TNF NOS2 MAP3K5 ATF2 MAPK14 MTOR BCL2L1 BCL2 NFE2L2 NQO1 RPS6KA5 SIRT1 MDM2 CCNE1 RHEB ATR NRF1 FOS CDKN1A PTEN IKBKB CREB1 KEAP1 IL1A UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP9 CAMK2A EGFR SMAD2 CREBBP EP300 RELA CTNNB1 HDAC5 TRPC4 CDK2 MAPK1 TNF MAPK3 PTPN11 MAPK14 AGTR1 CYBB BCL2 NCF1 NCF4 ABCA1 AIFM2 CYBA COL2A1 CDC2 VCAM1 GSK3B ACTA2 NPPB COL1A1 CASP9 MAPK9 COL3A1 MAPK8 CASP3 TGFB1 CHUK ALOX5 STAT3 BAX ESPL1 HMOX1 NFKB1 PLN IL6 UTS2R DDIT3 ARHA PCNA NCF2 UTS2 CCNE1 NPPA GSK3A NOX4 PTEN IKBKB MMP2 IL1B HSPA2 IRF3 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL5 ACSL3 STAR FABP4 LPA DBI SLC27A2 SORT1 APOC2 SLC27A3 SOAT1 APOC1 LIPA PCSK9 APOA4 SCARB1 APOB LDLR MYLIP FABP1 APOE SLC27A1 ABCA1 SOAT2 SLC27A4 ACSL1 STARD3 FABP2 ACSL6 NPC2 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis BMP7 TCF21 SIX2 WNT9B RSPO3 FOXD1 OSR1 ALDH1A2 GREB1L PAX2 MEIS1 FGF20 WNT4 WNT3A RSPO1 FGF8 NOTCH2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 CCL13 IL10RA ACKR3 CCL8 CCL7 CCL4 CCL1 CCL18 TNFRSF14 CCL15 TNLG5A LEPR ACVRL1 CCR10 CCR1 XCR1 IL2RA IL2RB IF2B1 IL23R IL15 GDF11 TNFRSF10A CD27 IL2RG IL-21 CXCL12 IL18RAP IL21R IL12RB1 IL10 CCR8 IFNGR1 EDAR CCR4 IL13 BMP8B IL2 IL4 IL5 CXCL8 IL5RA CSF2RB CCR3 IL3 IL3RA GH1 IL9 BMPR1A BMPR2 TNLG7C TNFRSF19 LTB IL1RN CXCL17 CXCL13 IF2D TGFBR2 CXCL14 IF2G IL36A CCR6 IL1A IL36B INHBA GDF5 IL36RN IL36G PPBP INHBB IFNW1 BMP4 IL1F10 CXCL6 IL24 FAS IF1IB1 IL27 CX3CR1 CXCL3 IL7 PF4V1 CSF1 IL19 XCL2 TNF IFNK XCL1 IFNL2 IFNL3 CCL20 ACKR4 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 TNFSF6 TWEAK TNFRSF12A IL1R1 ACVR2A IL27RA NGFR CSF3 CSF3R EPO IFNAR2 CNTFR TNFRSF1A IFNAR1 BMP3 CSF1R GDF10 CXCL5 GDF3 TPO IL7R NODAL TNFRSF21 IFNB1 NGF IL1R2 CXCL9 CXCL1 ACVR1B CCL3 TACI PRL CNTF EPOR CXCL2 CCR2 PRLR CCL23 CCL11 LIF LTA CX3CL1 CCL19 CCL5 CCL28 CCL2 IL15RA GHB2 IL18R1 GHR AMH CXCR4 CD40 IL25 CXCR6 IL34 IL10RB IFNGR2 IFNLR1 BMP10 TNLG7A IL6R CD40LG IFNG IL23A IL17F IL17D IL17C TNFRSF10B IL17B IL20RA IL20RB IL17A TGFB1 TNFRSF4 TNFRSF9 MPL ACVR1 IL22RA1 IL9R ACVR2B TNFSF11 GDF15 TNFRSF11A IL1RL2 TNLG2B CSF2 CXCL11 CSF2RA IL17RC IL17RB BMP6 IL17RA TGFBR1 IL11 IL11RA gdf7 TNFSF14 GDF1 GDF6 RELT IL6ST CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 BMP7 INHBC BMP5 TNFSF10 INHBE TNFRSF18 ACVR1C LTBR TNFRSF11B AMHR2 CCR7 IL1RL1 CXCR5 GDF8 LEP ANP32B BMP15 TNLG1B IL6 TNFRSF25 CCR5 IFNA2 TNFRSF13C TNFRSF10C TSLP CXCL16 CCL4L2 IL13RA1 IL8RB GDF9 IL18 TNFRSF1B CXCR1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNAI1 GNG2 KCNK9 CHRNA5 TH CHRNA6 KCNK3 PPP1R1B SLC18A2 DDC DRD2 DRD3 CHRNB2 CHRNA3 DRD4 GNB1 CDK5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA4 ITGB1 HLA-DMA CD63 CD151 SHH HBEGF LGALS3BP HLA-DRA CHST6 EXT1 CRY2 ALKBH3 HLA-DMB CHST1 LEF1 GLI3 CD82 MAPK8IP1 IGSF8 NRXN1 CD19 SPPL2C B4GALT4 PRDM11 ACCS PHF21A C11orf96 ALX4 TP53I11 LARGE2 EXT2 PEX16 IZUMO1 ITGA6 SDCBP SLC35C1 SYT13 VANGL1 MS4A1 FREY1 REST SLC25A17 B4GAT1 TIMP1 B3GNT7 PEX3 TSPAN18 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 TGFB1 CCR2 IL12RB1 IFNGR1 IFNGR2 IL12B CCR7 CCR4 IL12A IL2 IL4 IL5 CD40LG IFNG CCR5 CSF2 CXCR3 CCL4 IL18R1 CCR3 CCR1 CCL3 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA2 PDHA1 CHKA ACHE PEMT ChAT MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 SOCS3 MYC STAT3 CHI3L1 BAX IL6ST AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG2 CSN1S1 EIF4E EIF4G1 TSC2 EEF2 PRKAG3 PRKAA1 CSN3 EEF2K PRKAB2 RPS6KB1 PRKAB1 CSN2 PRKAA2 RPTOR MTOR EIF4A2 PRKAG1 MLST8 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 NFKB2 APOE RELA SPI1 TRAF6 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway EDN2 TSC22D3 PTGS2 SNAI2 POU5F1 B3GNT5 CDC42EP3 ACKR3 TNFAIP3 PMP2 ANGPTL4 MFGE8 IL11 RXRA NR1I3 FGD4 GPR153 CCL2 SERTAD2 CCL20 CAVIN2 PTGES3 NR1i2 KTN1 RGS2 NR3C1 DNER SCNN1A NFKB2 SLC26A2 ABHD2 DNAJC15 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 PPP1R14C ALOX5AP NAV3 ADGRF4 BIRC2 CDKN1C BIRC3 JUN PRRG4 STOM S100P SPRY1 THBD TNS4 PDE4B BHLHB2 SLC19A2 PLK2 AMIGO2 CPEB4 EPB41L4B ENC1 ANKRD1 FGFBP1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NDUFB10 MEF2D RELA VAV1 SH2B3 ZAP70 GRAP2 TNFAIP3 PDPK1 LCP2 CARD11 BCL10 SOCS1 LAT NFKBIA PTPN6 CDKN1B CUL5 MAP3K8 DGKZ SH2D1A REL PRKCQ LCK RASA2 DGKA TMEM222 MAP4K1 ARIH2 CD3G UBASH3A CD3E CHUK RPRD1B CD3D FIBP CD8A CD5 TRAF6 AGO1 IKBKG PLCG1 NFKB1 ARHH MAP3K14 ITK PIK3R2 PIK3R1 RNF7 GNA13 IKBKB GRB2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling IBSP PDGFRA COL1A1 TNFSF11 ITGB3 BGLAP PTH1R PTH TNFRSF11B SLC17A2 ITGAV FGF23 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 HEXB SCARB2 HEXA GM2A PSAP NEU1 NPC1 GLB1 NEU3 NEU4 GLA LIPA NPC2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits SRC NOTCH1 TCF7L2 TCF7L1 CXCR4 TNC LEF1 POSTN VHL VEGFA VCAM1 CYTIP GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GSTM2 GSTT2 GPX2 GSTA5 GSTM1 GPX3 OPLAH HEL-S-26 HEL-S-64p GPX1 GPX4 GCLM HEL-75 GCLC STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 INSIG1 NR1H2 INS DBI YY1 PRKAA2 PRKAG1 PRKAG2 SCARB1 CAMP ACACA LDLR FASN PRKAG3 PPARGC1B PRKAA1 LPL SIRT1 PRKAB2 IDI1 FDPS NFYA PRKAB1 SREBF2 HMGCS1 MVD SAR1B HEL-S-32 CDK8 CYP51A1 MBTPS1 HMGCR ACLY PIK3CA SAR1A RNF139 SEC23B FDFT1 SEC31B SEC31A AMFR SP1 SEC24C MBTPS2 SQLE MED15 FGF21 SCD MTOR ACSS1 PPARG GPAM RBP4 SEC23A GSK3A CREB1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 IRAK4 IRF7 STAT2 MYD88 STAT1 TRAF3 TRAF6 TBK1 IFNAR2 TMPRSS2 TYK2 IFNAR1 MAVS TREML4 RIGI ACE2 TLR9 TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 JAK1 IFIH1 IRF3 TLR3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GLS RPS6KA2 ARAF BRAF PFKFB2 DLD RPS6KA3 MAPK1 HEL-S-30 MAPK3 CPT1A RPTOR MAP2K1 MTOR MAP2K2 HEL-75 MLST8 ACSS1 PDHA1 RAF1 NAMPT PKLR SLC16A3 RPS6KA1 LDHB HEL-S-304 HEL-S-133P DLAT PPARGC1A GPX4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview PLA2G1B MMP9 BMX ANGPT1 PAK1 VEGFA GRB7 SRC KDR SHC1 PLXND1 PDPK1 MAP2K4 MAPK1 KRAS MAP2K6 ATF2 PTPN11 MAPK11 MAP2K1 MAPK14 RAF1 SLIT2 GRB14 MAP3K7 PXN F2 PRKCA ROBO4 PTK2B PIK3CD DAG1 MAPK8 CRK WAS PLCG1 NRP1 SHB TIMP4 BAD VHL MTOR APC CDC42 SEMA3A IQGAP1 FGFR1 ROBO1 NCK1 NOX4 MMP2 FRS2 RAC1 GRB2 SOS1 MMP14 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 CDH2 AK4 PTK2B CCR8 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 UGT1A10 CYP1A2 HSD17B3 CYP1B1 HSD17B7 SULT1E1 HSD17B2 CYP2C19 CYP3A7 UGT2A2 CYP3A4 HSD17B10 HSD17B4 HSD17B1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 MAD1L1 PTTG1 STAG1 CENPE CDC20 BUB1B SMC3 APC ESPL1 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GPR64 PTH2R CALCR ADGRL4 CRHR1 GLP1R ADGRL2 ADGRL3 ADGRE2 GHRHR PTH1R ADGRE5 ADCYAP1R1 ADGRL1 VIPR2 CRHR2 GIPR CALCRL GCGR SCTR TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways BCAT2 PSAT1 BAAT DHFR PSPH AMT CHDH GPX1 PHGDH HEL-S-44 HEL-75 GCLC pcap GAD2 CDO1 MTR HEL-S-75p GAD1 HEL-S-51e MTHFD2 TYMS DNMT3L GPX6 MAT1A HEL-S-64p GPX4 HEL-S-61p GPX2 CBS BCAT1 ALDH7A1 DNMT3B CTH GCLM AGXT2 PCYT1B CHKB AHCYL1 PCYT2 SLC25A48 CHKA BHMT2 ETNK1 AHCYL2 GPX7 PEMT MTHFD1 MTHFD2L CHPT1 GPX3 SHMT1 MTHFD1L CEPT1 HEL-S-182mP 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NLRP3 GDF5 ChAT DKFZp781O1323 JUND ATF2 BCL2 CUL5 SMARCC2 SIRT1 EIF4ENIF1 ELOA BMP2 SF3B1 MYBBP1A MAPK8 ERCC5 RIF1 SIRT6 NEO1 HSF1 MYO1C MEN1 DLD SMAD1 PCNA SMAD9 DDX21 OGDHL FAM170B CEFIP BMPR1A VSTM4 RGMB BAZ1B NOG WDFY4 PARG LRRC18 SLC18A3 ARHGAP22 HSF4 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 ITCH UVSSA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway ARL4A WDCP MIXL1 C9orf72 KLF4 KLF5 GATA3 RGS10 SETD2 HAND1 CTBP2 RPL38 LEFTY1 AMH LEFTY2 ZIC5 TBX6 NR2A1 HES7 SESN1 GATA6 TCF4 C1QBP TBX1 FOXH1 TBX3 CCND1 RARB PLCH1 YAP1 CRTC1 PIAS1 TRIM28 NABP2 DKK1 ACVR1 SMAD1 DNMT3B ACVR2B SCHIP1 SMAD6 BHLHB2 FZD5 BMPR1A FZD8 BMPR2 LATS1 TEAD2 SMAD2 SMAD4 INHBA SLC2A12 HTT TET1 FOXC2 FOXC1 SNAI1 BMP4 POU5F1 CUL4B PITX2 PAX6 MEIS1 SOX2 FOXA1 ARID5B CCDC6 ACACA BMP7 NFE2L2 FOXA2 LEF1 TCF7L1 HMGA2 ACVR2A WNT3 PRKAR1A WNT3A PPP2CA ZIC2 SOX21 SOX17 CEP250 WDHD1 AXIN1 EMSY AXIN2 WDFY2 HPRT1 BCORL1 TOX CSRP2 NLK MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 FGF8 GDF3 ZFHX4 TRERF1 PBX1 EXT1 FZD4 NODAL FGFR1 TRIM71 PHF6 ZIC3 TRIM5 JARID2 VAV3 NOG PARP8 NR1B3 TOX3 AEBP2 EXT2 AHDC1 ZNF462 ADAM19 ELP4 TWSG1 MSGN1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TAF13 TBP H4C9 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD4 RAD51 RAD54B BRCA2 MRE11A POLD2 ATM RAD52 RPA1 NBN POLD3 RAD50 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IF1IB1 TYK2 STAT2 STAT1 IRF9 JAK1 IFNL2 IFNL3 IL10RB IFNLR1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND2 ND5 ND4 TIMMDC1 ND6 NDUFB10 TMEM186 C3orf60 TMEM126B DMAC1 NDUFB11 DMAC2 COA1 NDUFAF6 NDUFAF4 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ACAD9 NDUFB9 NDUFB8 NDUFAF1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 ECSIT NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFA13 NUBPL NDUFAF2 NDUFS3 NDUFA12 NDUFA10 ND1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TSC2 TSC1 ARAF MAPKAP1 NRAS BRAF PIK3CA AKT3 IRS1 EIF4EBP1 MAPK1 KRAS SOS2 MAPK3 RPTOR MAP2K1 MTOR DEPTOR MAP2K2 PIK3R1 MLST8 PARP2 PARP1 RAF1 RPS6KB1 AKT1S1 INPP4B PTEN RICTOR HRAS GRB2 SOS1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R5 PIK3CD PIK3R3 PIK3C2G PIK3C2A PIK3C2B PIK3R4 PIK3R2 PIK3R1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A IL1R1 TGFB1I1 IL1B MAOA ITGB3 TPH2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum XAB2 POLK XPA GPS1 XPC CUL4A POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 SLX4IP GTF2H5 CUL4B SLX4 ERCC2 MNAT1 RBX1 CHD1L RPA3 RPA1 ERCC1 PCNA CETN2 PARP1 CDK7 HMGN1 H4C9 POLD3 H2AC6 RFC1 POLD4 HIST1H4L DDB2 POLE RAD18 BRCA1 H3F3B LIG1 POLE2 POLD2 POLE3 UVSSA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B SMAD2 SMAD4 C1QTNF12 VEGFA COMMD1 PANK4 INTS11 ISG15 INTS13 INTS14 INTS10 GDE1 TMEM52 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK SSU72 TNFRSF14 PEX2 ATAD3C GLTPD1 ACAP3 ELAVL1 RER1 CD160 SCNN1D PEX5 MXRA8 TNFRSF18 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 PEX12 MEPCE PUSL1 TAS1R3 NADK HES4 MRPL20 OR4F5 DVL1 HES5 OR4F3 CDK11A CFAP74 MIB2 PEX10 RNF223 LRP4 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 TRAF5 INTS9 SLC35E2B C1orf159 PLCH2 PRKCZ TGFB1 CALML6 GRIK2 DKK3 ARF6 TRAF2 TRIM25 TNFRSF4 PARD6B PHKG2 RBX1 VTN GNB1 AGRN MCM2 HEL-S-72p IFIT1 ATAD3A UBE2J2 SKI TNLG2B B3GALT6 INTS4 IFIH1 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 OMA1 LONP2 TSC2 SESN2 TSC1 GDF15 LONP1 FOXO1 SLC7A7 EIF2A CLPP MYC IRS1 PHB2 MTOR HSPD1 ATF4 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map TOMM70 SLC6A19 AQR UPF2 IGHMBP2 GDAP2 NLRP12 UBB MACROD1 HEL97 MACROD2 CMTR1 MAP3K7IP1 NRP1 ISG15 PAIP1 PARP14 UBC PALS1 MACROH2A1 ACE2 MACROH2A2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling ITGB1 PIK3CD MAPK10 EGFR COL1A1 MAPK9 MAPK8 NRAS SRC AKT3 TLN1 MAPK1 MAPK12 KRAS MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RAF1 PXN ITGA1 HRAS GRB2 AREG SOS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ERN1 SLC2A4 CD36 PRKCZ PRKAG3 MAPK8 INSR PDX1 RPS6KB1 EIF2AK2 TNFRSF1A INS IRS1 TNF TRAF1 MAFA PPP2CA ACSL1 PIK3R1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 IL1B RELA TRAF3 PYCARD NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CCND2 KLF4 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 WNT5B ELAVL1 WIF1 SOST LEF1 CCND3 NKD1 NKD2 DVL1 DVL2 TCF7L2 DVL3 TCF7L1 SOX7 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 MTDH FRAT1 FRAT2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CTBP1 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response ERN1 BCL2 NFE2L2 MBTPS1 BBC3 XBP1 RTCB HEL-S-89n CASP2 MBTPS2 IL1B PMAIP1 DDIT3 TXNIP TNFRSF10B EIF2S1 PPP1R15A BCL2L11 ATF4 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair PRKDC NASP MDC1 ATM H1-1 RNF168 H4C9 NBN HIST1H4L RAD51 TP53BP1 SETD2 RNF8 SUPT16H XRCC5 SSRP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 FADD CASP9 CASP3 BAX TRAF2 BIRC3 RIPK3 TNFRSF1A RIPK1 TRADD TNF CASP8 CYCS MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 CASP9 CHKA CASP3 PEMT ASMT CHPT1 GRIN1 EHMT1 ALDH7A1 CHDH DNMT3B HEL-S-61p CYCS 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome ATP2A1 RABEP2 SH2B1 INSR TRAF2 SLN NFATC2IP VAV2 TUFM ATXN2L SPNS1 KDR IFITM1 PLN IL4 SDCCAG8 MPL NFATC2 LAT RAB5A CD81 CD82 CD19 PRMT1 HEL-S-62p CR2 RAB4A TRAF1 GRB2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMPR2 NOG SMAD6 TOB2 SMAD4 RUNX2 SMURF1 SMAD1 BMP2 TOB1 BMPR1A RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling MAPK9 PAPSS2 MAPK8 RELA CHUK STAT1 TRAF3 FHL2 RELB TRAF2 GAB2 TRAF6 PLCG1 IKBKG MAP3K7IP1 JUN SRC NFATC1 NFKB1 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 MTOR NFKBIA LYN PIK3R2 SYK PIK3R1 CDC42 TNFSF11 SPI1 TNFRSF11B CBL TNFRSF11A MAP3K7 FOS NFKB2 SQSTM1 IKBKB RAC1 TRAF1 TRAF5 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NFE2L2 MAPK8 NQO1 CEBPB EPHB2 PIK3CA SLC7A11 HMOX1 PRKCA MAF GCLM AIMP2 KEAP1 GCLC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11B PMP22 FIG4 MPZ MFN2 KIF1B RABAC1 MTMR2 EGR2 RAB7A LRSAM1 RAB4B HSPB8 LITAF GDAP1 SH3TC2 FGD4 RAB25 HEL-S-102 RAB4A RAB11A NEFL SBF2 RAB3B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR AHCYL2 MTHFD1 SHMT1 HEL-S-51e MTHFD1L TYMS MTHFD2 DHFR MAT1A AMT TCN2 HEL-S-70p CHDH MTFMT GLRX DNMT3B MTHFS FOLH1 HEL-S-61p FTCD NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK1 FLNA MAPK3 PTK2B RPGRIP1L INVS NPHP1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DOLPP1 MGAT4B STT3A STT3B ALG1 FUT8 B4GALT1 DPM2 MGAT1 MPDU1 B4GALT2 TUSC3 ALG6 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 RFT1 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B DPM1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions FOXO6 WWTR1 KNSTRN RAB13 FERMT3 YAP1 FOXO1 FOXP3 RAP1A ARHA STK38L FYB1 MAPK14 MOB1A PRDM1 LPL FOXO4 FOXO3A YWHAQ CD19 CCR7 LATS1 TEAD4 LATS2 RAC1 TEAD2 TEAD3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 TLR4 IRAK4 IRF7 MYD88 TICAM2 RELA CHUK TRAF3 RELB TIRAP TRAF6 TBK1 IKBKG NFKB1 TLR5 MAPK1 TLR9 TLR7 IKBKE TLR1 TICAM1 NFKB2 IKBKB REL IRF3 TLR8 TLR3 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling TLR4 TIFA IRF7 CISH TREM1 SOCS1 CCL5 RBCK1 CCL4 NFKBIA PTPN6 MLST8 IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B MAP3K7 IL12A PIK3R3 SQSTM1 MBL2 MAPK10 MAPK9 MAPK8 SFTPA2 LBP CYLD TLR5 CXCL8 CASP8 SPP1 ZMYND11 PIK3R2 SYK PIK3R1 PLK1 IRAK3 PELI1 SMAD6 FADD IKBKB RAC1 CXCL11 IRF3 CD14 TLR8 TLR3 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 FBXW5 LY96 IFNA21 TRAF3 CD180 IF1AA9 TRAFD1 TIRAP SIGIRR CUEDC2 SFTPD MAP3K7IP1 RNF31 PELI3 SARM1 TNFAIP3 IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RIPK1 IFNA7 TICAM1 NFKB2 BTK IRAK1 IRAK2 PIK3CD IRAK4 TAB3 MYD88 OTUD5 CHUK TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 IFNA2 TLR9 TLR7 TMED7 PIK3R5 RNF41 FOS IFNB1 IL1B CXCL9 IFNA1 CCL3 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response IL15 TGFB1 CSF3 CXCL2 PDGFA IL10 IL13 HLA-DRB1 IL2 IL4 IL6 IL5 IL7 CSF1 IL11 TNF HLA-DRA IL3 IL12B IFNB1 IFNG IL1B CSF2 CXCL1 IL1A PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA4 PSMA2 PSMC1 PSMB6 PSMB2 PSMB3 NEDD4 UBE2D1 PSMD9 PSMB10 HLA-A UBE2B HEL-S-276 PSMD6 PSMB8 HLA-B HEL-S-283 PSMD7 HLA-F PSME2 HLA-G HLA-C HLA-E PSMD4 PSMD5 PSMD2 UBE2D3 PSMD3 PSMD1 UBE2D2 H2AX UBB HIST1H2AB H2AZ1 PSMD10 UBA7 PSMD12 PSMD11 HEL-117 HEL-S-91n PSMD13 RPN2 UBC RPN1 IFNG PSMC6 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA NR1i1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways MEF2C CREBBP EP300 CTCF ASCL1 CAV3 CEBPB SCN3B NKX2-2 BDNF GATA3 SNTA1 GATA2 SCN4B HDAC9 NKX3-1 YBX1 TLX3 POU3F2 PHOX2B C4B_2 SST POU2F2 C4A IL6R TCF3 DLX2 HIF1A G6PC1 GCK TF RORA MAP2 PAH IL10 HEL-S-162eP IL13 CXCL8 CHRNB2 CPT1A ECE1 EN1 BHLHB2 CREM PPARGC1A IL1RN EGR1 FREP1 IL1A AQP4 TACR1 SLC9A3 FOXM1 VEGFA TPH2 POU5F1 TPH1 ChAT GRIN1 FEV CTNNB1 PKNOX1 TNF TSPYL1 CHRNB4 DEAF1 SPTBN1 PHOX2A SOX2 MYB NR3A2 CC2D1A HEL2 NOS1AP KCNJ8 GPD1L HEL-S-125m LMX1B AVP CHRNA7 PPARGC1B HADHB 5HT1A GJA1 NR3C1 HDAC1 NEUROD1 HES1 NFYA HES5 NFKB2 PRKAR1B PRKAR1A REST SP3 RET ACADM CHRM2 SCN5A TP73 CASP3 HTR2A JUN NFKB1 SLC25A4 IL6 NTRK2 SP1 DDC NR1A2 MAOA HEL-S-87p ADCYAP1R1 VIPR2 GNB3 SNAP25 PBX1 SSTR2 RYR2 SLC1A3 YWHAQ TH HEL-S-1 YWHAG YWHAZ NGF CREB1 RUNX3 IL1B HSPD1 VAMP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2C19 CYP2C9 CYP2B6 CYP2C18 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 TMEM120B MDH2 TMEM120A SSC4D POR RAF1 STYXL1 HEL163 PTPMT1 KIF1C SFN EPB41L3 YWHAG LMNA RHBDD2 ZP3 ZP2 HEL-S-102 DAPK2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling STAT2 STAT1 MAPKAP1 GAB2 MAP3K1 VAV1 ZAP70 TYK2 SOCS3 SOCS1 IRS1 MAP2K3 EIF4EBP1 PTPRC FYN MAP2K6 RPTOR PTPN11 MAPK14 PTPN6 MLST8 EIF4E EIF4B RPS6KA4 RPS6 IRF9 RPS6KA5 RPS6KB1 PRMT1 REL LCK PIK3CD STAT3 STAT4 IFNAR2 CRK PIAS1 IFNAR1 RAP1A CRKL MTOR PIK3R2 PIK3R1 EIF4A1 RAPGEF1 CBL CREB1 RAC1 JAK1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD AGPS LPIN1 IPMK LPIN2 PIK3CA HMFN0839 PLA2G2A PI4K2A PTDSS1 CHKB PCYT2 PTPMT1 GPAM PEMT MOGAT3 GPD1 CHPT1 PGS1 CEPT1 CRLS1 GPAT2 GPAT4 CDS2 PIP5K1A GNPAT CDIPT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA CMKLR1 PIK3CD FPR2 EPHB2 MTOR GRK1 LTB4R HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 CD36 HIF1A HEL-S-133P PPARG GPD1 HEL-S-49 HEL-S-162eP NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2 POLA1 MTHFD2 OAZ1 DHFR HPRT1 POLG RRM2B ADSL NME2 SRM IMPDH1 ADSS FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 FABP4 CEBPA KLF5 INS PIK3CA GATA3 GATA2 PLIN1 NR1C1 MGLL KLF2 LMNB2 PNPLA2 PPARG LPL LIPE ZMPSTE24 FNTA BANF1 LMNA CIDEC ICMT PRRX1 STAT5B CIDEA SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 SLC6A19 FURIN ACAT1 CTSL TMPRSS4 ACE2 NRP1 TLR7 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP1 AGPS LPL GPAM MOGAT3 GPD1 LIPF LIPE AGPAT4 AGPAT5 MOGAT2 MOGAT1 AGPAT3 DGAT1 GNPAT LIPC DGAT2 PLPP3 PNPLA2 PLPP2 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 TIFA UBE2V1 NFKB1 SQSTM1 PRKCZ HEL-S-71 TRAF6 IL1A AJUBA SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RAF1 RASGRF1 HTR2B NRAS HTR2A GATA4 MAPK1 KRAS MAPK3 HRAS MAP2K1 MAP2K2 MAPKAPK2 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade MAPK10 MAP2 ARAF MBP NRAS BRAF MAP3K1 MAP3K2 JUN LAMTOR3 RRAS MAP2K3 MAPK1 MAP2K4 MAPK12 KRAS SOS2 MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 RASA3 RAF1 SIPA1 PLCB3 HRAS GRB2 MAP3K12 SOS1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 PIK3CD PTGS2 BAX CRP CCND3 COL4A1 HMOX1 PTGS1 IL6 NFRKB AKT3 CXCL8 TNF LAMA3 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing OAS1 TREX1 RNASEL ADAR RNASEH2C IFNB1 RNASEH2B RNASEH2A MAVS RNASET2 CGAS RIGI MITA IFIH1 IRF3 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies USP9X ADCY6 XPNPEP3 DYNC2I2 CEP19 INVS NPHP3 DYNC2H1 DYNLT2B SUFU DYNC2LI1 KIF7 OCRL RP1L1 IFT172 PKD1 DNAJB13 PIK3R4 RSPH9 SMO AHI-1 IFT81 TCTN3 CENPF GPR161 TCTN2 INTU TCTN1 RSPH3 ALMS1 HEL-S-296 IFT27 CC2D2A RPGRIP1L RSPH1 TMEM138 SPAG1 NPHP1 TULP1 PIBF1 CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 C2CD3 B9D1 RAB23 B9D2 CCDC41 KIAA0753 CCDC40 OFD1 ANKS3 BBIP1 PDE6D NEK9 PLK4 ZNF423 CRX TRAF3IP1 CEP164 FLCN IFT52 TMEM107 ODAD1 CNGA1 ODAD3 NEK1 ODAD4 BBS9 CCDC28B BBS7 MCIDAS IFT57 NME7 TBC1D32 BBS5 NEK2 CEP290 DNAAF3 DNAAF2 ZIC2 BBS4 DNAAF6 IQCB1 CFAP418 FAM161A CCNQ IFT140 IFT80 CCNO CFAP410 AK7 CEP78 WDR35 LZTFL1 DNAAF19 ARL2BP EVC DNAL1 BBS10 DNAAF11 IFT43 HYDIN BBS12 CCDC39 RP2 MAK CFAP52 DNAI2 TMEM216 TOPORS EFHC1 WDPCP RP1 NME9 WDR51B CNGB1 ZMYND10 SDCCAG8 CEP104 KIZ ARL6 CFAP53 ARL3 KATNIP DNAH6 PKD1L1 PKHD1 CFAP298 ARL13B POC1A TMEM67 RAB28 INPP5E DNAI1 EVC2 TUB BBS2 DYX1C1 NEK8 RPGRIP1 BBS1 TTLL5 PCARE HYLS1 SCLT1 ATXN10 DCDC2 TTC8 MKS1 CEP41 TRIM32 GLI3 CLUAP1 DRC1 CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis SCARB1 NR1H4 LDLR SLC22A1 ABCC2 ABCB4 SLCO1A2 HMGCR ABCC3 ABCB11 EPHX1 RXRA NR1I3 ABCG8 ABCG5 ATP8B1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 GOT2 SLC25A12 GLUD1 SLC25A13 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYP11A1 SRD5A2 POR HSD17B6 STAR AKR1C4 AKR1C2 HSD17B3 CYP17A1 HSD3B2 FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism RELA INSR CRP FLAD1 DHFR INS CSF1 TNF GPX1 CCL2 HEL-S-44 SCARB1 APOB SERPINA3 LDLR SLC19A1 MTRR SAA4 HBB MTR PLAT FOLR1 PLG HEL-S-51e MPO MTHFD2 ABCA1 FGA HBA2 GPX6 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG ALB SAA1 SAA2 GPX4 GPX2 CBS NFKB1 IL2 IL4 IL6 CTH MTHFS SLC46A1 IZUMO1R FOLR3 MTHFD1 FOLR2 GPX3 SHMT1 IL1B INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB1 PAK1 ARHGEF7 VASP CAV3 BRAF VAV2 CAPN3 DOCK1 SRC SHC1 ZYX PDPK1 AKT3 MAP2K3 MAPK1 MAPK12 FYN MAP2K6 MYLK2 MAP2K1 SHC3 MAP2K2 HEL-S-28 RAF1 HEL114 ITGB3 ITGA2B RAC3 PXN CAPN10 ITGA1 PAK6 SELENOP PAK4 ITGA2 ITGA4 MAPK10 ITGB7 MAP2K5 ARAF RHO CRK ROCK1 CAPNS1 ROCK2 MAPK7 RAP1A CAV2 TLN1 PIK3R2 CDC42 RAPGEF1 MYPN ITGAM ITGB5 ITGB4 CAPN9 CAPN6 ITGAE CAPN7 CAPN5 ITGB8 TNS1 ITGAV GIT2 ITGAX ITGB6 CAPN11 VAV3 MAPK6 ITGA7 ITGA6 MAPK4 RAC1 HRAS CSK GRB2 SOS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIST1H4L H2BC12 CHAF1A RBBP4 HIRA H4C9 SMIM40 IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling TICAM2 RELA CEBPB FAS CTNNB1 CSN2 MAPK1 TNF MAPK3 IL18R1 NFATC4 NFKBIA ELAVL1 IL37 PRKAA1 TNFSF6 NCF1 RPS6KB1 PRKCB MAP3K7 IRF1 PRKCA ACACB HEL-S-102 LCK CYCS GSK3B IRAK1 MAPK9 MYD88 CASP3 CHUK IL18RAP BAX TRAF6 TNFRSF1A GATA1 NFKB1 SP1 CASP8 PIK3R1 PARP1 NCF2 IMP3 SLC12A3 GRIN2B PTEN IL18 IKBKB NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium GSK3B MAP1B MEF2C GHRL NGFR APP ID2 ASCL1 MAP2 STAT3 CXCL12 MRE11A ID1 BDNF KDM1A PLXND1 CDK5R1 MYC NTRK2 PAX6 NRG1 ERBB4 DAB1 AGRN SOX2 DISC1 NUMB NOTCH1 PSEN1 PAFAH1B1 NEUROD1 RTN4 NDEL1 HES1 TCF4 LRP8 NTRK1 TCF3 NEUROG3 FAIM NTRK3 NGF RELN VLDLR CDK5 IL17A RET RTN4R CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K1 IGF1 TGFBR1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 NFATC2 MAP2K1 MAPK14 MAP2K2 CDK9 EGF RAF1 IKBKE FGFR2 MAP3K7 PRKCA PRKD1 GSK3B MAP2K5 MAP4K1 MAPK8 TGFB1 CHUK IKBKG TNFRSF1A MAPK7 NFKB1 MAP3K14 MTOR CALM1 CDK7 FGF2 NPPA GUCA1A IKBKB PPP3CA RAC1 CAMK2D 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome METTL27 STX1A FKBP6 VPS28 ATPAF1 TRIM50 HDAC2 FBLN2 ATP8 FBLN5 ATP6 MVB12A CLASP2 ATP5MC2 TMEM270 TBL2 ATP5MC3 GTF2IRD1 FAS CTNNB1 CLDN1 MYC ATP5G1 PRKG1 NRG1 HDAC6 MAPK3 ABHD11 TSG101 ACACA MLXIPL H2AX USF1 HEL-S-123m FBN1 EIF4H ATP5PB EIF2A ATP5F1D GTF2I ATP5F1E SQSTM1 ACACB ATP5PO RB1 BTK SF3B1 ATF4 MYBBP1A HEL-S-15 HMGA1 RFC2 CHTF18 CLDN3 UBE2L6 CDKN1C HEL-S-162eP MYO1C CLASP1 DLD LIMK1 GRIP1 ULK1 SNAP25 CLDN5 CLTC PCNA CLDN4 BRD4 LAT2 PKLR NUP62 DDX21 UBIAD1 FZD9 OGDH BAZ1B BCL7B BUD23 VPS9D1 HDAC3 ATPAF2 UBE2E3 SMARCA5 VPS37C HSPA2 DEK HEL-S-271 UBE2E1 VPS37D GRB2 VPS37A HOXC8 VPS37B CLIP2 VAMP2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB4 TLR4 CAMK2A PLCB1 PLCB2 STAT2 STAT1 IFI44L NRAS IFI27L2 CAMK2G RSAD2 TYK2 ISG15 CYP27B1 RXRA MAPK1 TNF NR1i1 MAPK12 KRAS MAPK3 MAPK13 CCL2 MAPK11 MAPK14 CAMP OAS2 DEFB4B CD40 PRKCH IFNGR2 PRKCB PRKCE PRKCA NFKB2 CD40LG IFNG PRKCQ SP3 RXRB NOD2 PRKCZ MAPK9 RXRG CYP24A1 MAPK8 RELB PLCG2 IFNAR2 IFNGR1 JUN TNFRSF1A MAPK7 NFKB1 IL6 SP1 CXCL8 IFNA2 PLCE1 PLCB3 IKBKB JAK1 HRAS CAMK2D TLR8 MED1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17RA IL17A SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 HMGB1 IKBKB THBD CHUK RELA NFKBIA IKBKG AGER MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression GABPB1 TFAM PPARGC1B MYEF2 HCFC1 POLRMT GABPA MTERF3 MTERF1 NRF1 SP1 CREB1 PPP3CA PPARGC1A TFB1M TFB2M PPRC1 ESRRA CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network RAD54B SMUG1 REV3L ERCC2 POLI FANCD2 FAN1 H2AX FEN1 MPG PNKP OGG1 NBN UNG RFC1 POLD3 POLD4 NTHL1 DDB2 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 NEIL2 APEX1 POLE3 RAD52 CHEK1 WDR48 XPA XPC CUL4A ERCC5 RFC2 GTF2H2C_2 CCNH MSH6 GTF2H2 FAAP24 GTF2H3 MSH2 BRIP1 GTF2H5 FANCM MNAT1 CENPX RAP1A FANCL REV1 WRN FANCA POLM NHEJ1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C PARP2 ERCC1 CENPS CETN2 CDK7 ATM ATR BRCA1 BRCA2 POLD2 XRCC5 TDG POLE4 MRE11A MSH3 DDB1 RAD50 CUL4B RAD51 HMGB1 RPA3 RPA1 MGMT POLK RFC3 RFC4 RBX1 PRKDC PCNA PARP1 TERF2 PMS2 USP1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF5 MED23 TAF8 MED27 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 MED30 MED31 POLR2M POLR2L TAF10 TAF11 MED14 TRFP CRSP9 TAF1 TAF4 TAF3 POLR2A THRA CDK8 POLR2D GTF2B TAF9 CTDP1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TAF13 MED15 TAF7 TAF6 TBP CCNC TAF12 MED9 NELFB NELFCD NELFA POLR2C MED1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1D HTR1B HTR1F GNAI1 STAT3 BRAF HTR2A MAP3K1 GNAI3 PIK3CA MAPKAPK3 PDPK1 RAP1A MAP2K3 MAPK1 ARHA MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 GNAO1 5HT1A RASGRF1 RPS6KA5 FOS CREB1 MAPKAPK2 HTR1E GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS ALDH5A1 GAD2 GLS2 GAD1 PON3 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 PARP1 NAMPT SIRT1 SIRT3 SIRT6 NADK NRK SIRT4 NT5E SIRT5 SIRT7 NMNAT3 NMNAT2 SIRT2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GCK UXS1 PGM3 HK3 HK2 GFPT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB GC CYP27B1 CYP24A1 RXRA DHCR7 NR1i1 PTH CYP27A1 CYP2R1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH RAF1 PRKAA1 NFKB1 PRKCA DUOX1 RAP1A CLCN5 CREB1 HEL-S-5 PRKAA2 SLC5A5 MAPK1 DUOX2 MAPK3 TSHR MAP2K1 TG MAP2K2 CGA TPO NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6R IL6 SOX4 IL11 STAT3 RELA IL11RA JAK1 JAK3 IL6ST PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 PTGER1 PTGER3 PRL PTGS2 ANXA6 EDNRA AKR1C1 AKR1C2 S100A6 SOX9 EDNRB CYP11A1 ANXA2 PPARGC1B PPARG PTGFR HPGD AKR1B1 EDN1 PTGS1 HEL-S-7 TBXA2R PTGDR PTGIR PTGIS PTGFRN PPARGC1A ANXA3 PTGER4 ANXA4 ANXA1 SCGB1A1 PTGER2 S100A10 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A8 SLC30A2 SLC30A5 SLC39A14 SLC30A4 SLC30A1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC39A8 MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACSL3 HSD17B10 EHHADH ACADSB ACADL DECR1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling ADCY3 PLCB1 MYL12B GNG2 STAT1 BRAF IGF1R SRC PDPK1 CDK4 MAP2K3 CDK2 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 RAF1 CDKN1B RPS6 CCND3 RPS6KB1 RBL2 RB1 APEX1 KCNIP3 GNAI1 STAT3 TSHB RAP1GAP SCRIB GNAI3 PIK3CA RAP1A GNB1 GNAS TSHR MTOR CGA GNAO1 PIK3R2 PIK3R1 CCNE1 RPS6KA1 PDE4D GNA13 CREB1 JAK1 HRAS PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NOTCH1 RBPJL CTNNB1 FGF10 PTF1A PDX1 RBPJ KAT2B PROX1 NKX6-1 HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MMP9 SRD5A2 CREBBP SIRPA EP300 CHD2 SOX5 TRIP13 ERCC2 CYP26B1 HLA-DRA PON2 CDK9 PON1 APOB TMEM132E CYP17A1 RFC1 PEX10 AHR HMGA1 XPC CCNK PRDM9 REC8 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 SPATA17 TSSK4 DDX4 DAZ4 THBS1 DAZ3 VCX DAZ2 CLU MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 FOLH1 PIWIL4 GNAO1 SPO11 XRCC3 HORMAD2 MSMB ERCC1 PRMT6 PACRG TEX15 CXXC1 ABLIM1 OR2W3 P1 USP26 NQO1 CDC42BPA MDM2 MLH3 ATM CTCFL ABCB1 SEMG1 CYP1A1 BRDT BRCA2 MMP2 DND1 FAT10 XRCC5 INSR PSAT1 KDM3A FAS AHRR UBE2B TNF MAS1L GPX1 NR3A2 BCL2 MTRR SLC16A7 NFE2L2 MTR TNFSF6 TCN2 MSH4 HEL-S-61p AGO2 STRA8 POLG HEL110 NOS2 PARP1 SLC46A1 PEMT MTHFD1 SHMT1 H4C9 DAZL PMS2 H3-4 ETV5 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease ANGPT2 SMAD2 LTBP1 SMAD4 MAPK8 NR2C2 RUNX2 FBN1 TGFBR3 CTGF FBN2 TGFBR1 FBN3 LTBP2 SHC1 MAPK1 FLNA ENG MAPK3 POSTN MAPK14 TGFBR2 AGTR1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 CS SDHC SDHD SDHB SDHA OGDH ACO2 IDH3B FH SUCLA2 DLD SUCLG2 SUCLG1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN ACE2 VEGFA NRP1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 HSD11B2 EBP SLC27A5 THEM5 DHCR7 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 ACOT9 AMACR ACOT6 SLC27A2 NPC1 ACOT4 DBP CYP7A1 EPHX2 CYP27A1 NPC2 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway MMP9 EGFR SMAD2 RELA STAT1 INSR TIRAP INHBB FOXO1 SRC INS SHC1 IRS1 MAPK1 MAPK3 ATF2 HEL-S-44 MAP2K1 MAPK14 NFKBIA RAF1 ALPL NCF1 AGER PRKCB PRKCA HIF1A STAT5B EZR CYCS IRAK4 CASP9 PRKCZ MAPK9 MAPK8 MYD88 CASP3 CHUK STAT3 ROCK1 JUN NFKB1 SP1 CASP8 ARHA NOS2 CDC42 FOXO4 DDOST HEL70 MSR1 MMP7 IKBKB MMP2 RAC1 MMP14 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 ABCC2 SLC51A SLC51B SULT2A1 ABCB1 BAAT ABCC3 SLCO1B1 ABCB11 CYP3A4 NR1I3 NR1i1 CYP7A1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 CDKN1A HIF1A ABCB1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation HEL70 CNP MBP GAP43 FREP1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome NKX2-5 CDC45 CYP26A1 HIRA HIRIP3 PAX3 CYP26B1 GBX2 HEL25 SLC2A4 CYP26C1 FGFR2 SREBF2 TBX1 GSC2 HAND2 PAK4 CDH15 ACTA2 RORC CLDN3 PARK2 SLC25A1 HEL-S-80p DGCR8 DROSHA CRKL GP9 SNAP29 PLK1 SERPIND1 SEPT5 TXNRD2 TSKS ZDHHC8 RCC1 C22orf39 DRD2 THAP7 TSSK2 RTL10 HDAC3 NPRL2 TRMT2A ESS2 KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L GP1BA TNPO1 ASF1A SCARF2 EGFR DGCR2 GP1BB C16orf35 SLC7A4 GNB1L DEPDC5 FOXC2 CCDC188 FOXC1 ARVCF RANBP1 P2RX6 SHH ZNF74 PITX2 FGF10 CLDN1 NCOR1 BCL2 RAF1 FOXA2 RTN4 HES1 ALDH1A2 EMC10 POLR2A RELN RTN4R RBX1 MED15 FGF8 CLDN5 CDC42 UFD1L FGFR1 GLUD1 H4C9 CLTCL1 VWF RAN SHOC2 PRODH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling EGFR CREBBP STUB1 SMAD4 EP300 RUNX2 RELA FHL2 FOXO1 EFCAB6 HEL32 SRC KAT7 KDM1A PIAS2 CTNNB1 ZNF318 FKBP4 RNF6 RNF4 TGFB1I1 BAG1 FLNA PATZ1 NCOR1 SMIM40 UBE2I SUMO1 SIRT1 HDAC1 TGIF1 RB1 PAK6 KAT2B CCND1 ZMIZ1 GSK3B RAD9A STAT3 TLE5 PIAS1 ROCK1 KAT5 ROCK2 UBE3A JUN HEL-S-99n PSMC3IP SP1 ARHA RLN1 PIK3R2 NCOR2 PIK3R1 CDC42 NR2C2 RHOB MDM2 CCNE1 HEL-S-67p NR0B2 PTEN BRCA1 CREB1 RAC1 RAN SIN3A CARM1 LIMK2 NCOA1 SMARCE1 ETV5 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFD HEL-S-62p ICMT LMNB2 RCE1 FNTA LMNA CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 MDH2 ALDH7A1 HEL-S-5 GCDH L2HGDH D2HGDH APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3B BCL2L1 BCL2 BCL2L2 BAK1 ITGB4 BAX BOK PTHLH GSK3A MYC AKT3 BCL2A1 BCL2L10 ITGA6 BCL2L12 BCL2L14 MCL1 BCL2L13 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis GAD2 PAH GAD1 ASMT TH TPH1 ChAT AANAT DDC ACHE MAOA HDC PNMT DBH LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 TRIM71 EGR1 SOX2 POU5F1 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ITGB1 MYL12B DCC SLIT1 SHH SLIT3 TRPC1 SRC PDPK1 MAPK1 MET FYN RYK gdf7 SEMA5B RHOD ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 RAF1 ABLIM3 ROBO2 LRIG2 CXCR4 SRGAP2 NTNG2 NGL1 SLIT2 EPHA2 PRKCA WNT4 NTN3 PARD3 CDK5 ARHGEF12 GSK3B RGMA HEL-S-15 PRKCZ EPHB1 GNAI1 CXCL12 ROCK1 NRP1 PARD6A RRAS PLXNA1 PTCH1 EFNA1 CDC42 SEMA3A BOC L1CAM FES FZD3 ROBO1 NCK1 BMPR2 RAC1 HRAS CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NCOA6 ABCC2 DNAJC7 SULT1A1 FOXO1 UGT1A4 CYP2C19 SP1 CYP3A4 RXRA NR1I3 UGT1A3 CYP2C9 CYP2A6 CYP2B6 SULT2A1 UGT1A1 EHHADH ABCB1 UGT1A9 ABCC3 SMC1A PTPA PPARGC1A CYP4A11 ALAS1 NCOA1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 OAS1 STAT1 IFI35 IRF9 IFIT3 IFNAR2 PIAS1 IFNGR1 IFNGR2 TYK2 IFIT1 IRF1 IFNAR1 IFITM1 PSMB8 SOCS1 IFNG JAK1 MX1 TAP1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FST SMAD4 KRTAP8-1 BMP6 IGF1 MSX2 EGR2 BMP4 SFRP1 CD200 PERP GATA3 CTNNB1 CD34 CASP14 MSX1 SOX2 SOSTDC1 TP63 NOTCH2 ADAM17 NOTCH1 ZBTB16 WIF1 NR3C1 LEF1 HR Nbla10317 ATL1 HOXC12 KRTAP3-3 PHLDA1 IGFBP5 KRTAP15-1 SPINK6 SPINK5 TCF4 ADAMTS20 DSG1 TCF3 DSG4 IFNG GPR49 DLX3 KLK5 KLK4 GPRC5D LRIG1 KRTAP6-1 FOXE1 KRTAP2-4 GSDMA KLK13 KLK14 FOXN1 GTPBP4 KRT19 GJB6 KITLG GAS1 DKK3 FOXQ1 CTGF JUN NFATC1 NFKB1 DKK1 DKK4 RBPJ SMAD1 ELANE SOX9 DSC2 FZD1 BMPR1A FOS S100A4 RUNX3 KLK6 CD133 FOSB ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1A2 RELA CHUK GUCY1B1 IKBKG TMPRSS2 HMOX1 NFKB1 IL6 CXCL8 RXRA TNF CCL2 ACE2 GCLM NFKBIA GCLC NFE2L2 NQO1 SLC7A11 IL12A IKBKB IL1B MMP3 IRF3 KEAP1 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B10 UGT2B4 PGM2 UGT1A8 PGM5 UGT2B7 UGT1A3 UGT1A10 UGT1A1 UGT2B28 UGT1A9 UGT1A5 UGT2B11 UGT1A4 UGT2B15 UGT2B17 UGT1A7 UGT2A2 PGM3 UGT2A1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 MTR FOLR1 MTHFD1 MTHFD2L SHMT1 HEL-S-51e TYMS MTHFD2 DHFR HEL-S-70p MTHFS FTCD IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 HSCB ABCB7 FDX1 NFU1 FDXR CIAO2B FXN ISCU NUBP1 NUBP2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF EGFR RAF1 CASP3 HTT RPS6KA5 BDNF NTRK2 CREB1 MAPK1 MAPK3 HRAS MAP2K1 MAP2K2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND2 PRL EPOR STAT1 STAT3 EPO CISH NRAS PRLR FOXM1 IFNGR1 SOCS2 CDK4 SOCS3 IL6 SOCS1 AKT3 KRAS RPTOR GHR MTOR MLST8 GH1 CCND3 IFNGR2 AKT1S1 IL6R IFNG STAT5B HRAS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH ME1 BRAF HEL-S-32 PDP2 ME2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 UGT2B4 CYP8B1 SLC27A5 ABCB4 SULT2A1 NR0B2 SLCO2B1 BAAT ABCB11 FGF8A FKBP5 CYP3A4 RXRA PPARGC1A IP6K3 CYP7A1 NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation TLR4 COX1 MAPK8 CHUK RELA JUN ASCC1 FOS NOS2 MAPK14 MTOR NFKBIA COX2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CREB1 MTR ADH5 CEBPB CBS CYP2E1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ASS1 ARG2 GLUD1 ARG1 ALDH18A1 SMS OTC HEL-S-29 HEL-S-5 SRM HEL-S-20 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFB10 NDUFB11 CEBPA COX7A2 NDUFV3 NDUFV2 SOCS3 NDUFC2 NDUFC1 PRKAA2 NDUFS6 NDUFS5 NDUFS4 CCL2 NDUFS1 COX2 NDUFB9 BCL2L11 NDUFB8 PRKAG1 NDUFB7 PRKAG2 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 PRKAG3 NDUFB1 BBC3 NDUFA7 LEPR NDUFA6 PRKAB2 NDUFA5 ZNF183 NDUFA3 PRKAB1 NDUFA2 IL6R PIK3R3 ADIPOR1 NDUFAB1 ADIPOR2 VCAM1 MAPK9 MAPK8 TGFB1 BAX COX7B COX4I1 COXFA4L2 COX6A1 CXCL8 DDIT3 CASP8 COX8A PIK3R2 COX6B1 PIK3R1 COX7A1 SDHC XBP1 SDHD UQCRB SDHB COX3 CYP2E1 UQCR11 UQCR10 GSK3A CYB UQCRH UQCRQ UQCRC1 IKBKB UQCRFS1 CYC1 RAC1 UQCRC2 IL1A BAK1 INSR RELA INS FAS NR1C1 AKT3 IRS1 RXRA TNF MAP3K5 MAP3K11 ERN1 NR1H4 MLXIPL PRKAA1 TNFSF6 COX4I2 NR1H3 EIF2S1 CYCS ATF4 GSK3B LEP COX1 PIK3CD CASP3 TRAF2 SDHA JUN TNFRSF1A NDUFC2-KCTD14 PIK3CA COX6B2 NFKB1 COX7B2 MLX IL6 COX8C MLXIP UQCRHL NDUFA13 CDC42 PKLR COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 IL1B NDUFA9 NDUFA12 NDUFA10 COX6A2 ITCH COX7A2L SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B2 SLCO4C1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 NR3A2 SULT1E1 HSD17B1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 B3GALT2 B3GALT1 FUT3 FUT1 FUT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin ANGPT2 ANGPT1 VEGFA GATA2 CX3CL1 CCL8 CCL5 MAP2K4 HLA-G CCL7 TNF MAPK3 CCL2 IL15RA CCL4 MAPK11 NR3A2 BCL2 PGR CXCR4 NR3C1 IFNG STAT5B JAK3 MCL1 VCAM1 IL2RB ITGA4 IL15 IL2RG CXCL12 IL10 IL4 IL6 CXCL8 GAB3 NCR2 MADCAM1 KIR2DL4 IL3 SELL CD69 PIBF1 JAK1 CXCR3 CXCL11 NCR1 NCR3 CCL3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 CHDH SLC44A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ITGB1 CLDN4 ZEB2 TGFB1 ALPL SFRP1 TERT MYC ITGA6 TNF NRG3 ERBB4 CCND1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK1 TLR4 IRAK4 IRF7 MYD88 CHUK TRAF3 TIRAP TRAF6 TBK1 IKBKG MAP3K7IP1 TRAM1 NFKB1 IL6 CXCL8 TNF INPP5D NFKBIA IRAK3 IKBKE RIPK1 MAP3K7 TICAM1 IFNB1 IKBKB IRF3 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell AP3D1 ARCN1 SPCS3 NEDD4 LAMTOR5 HEL-S-30 MET POGLUT3 AXL TPM3 TPM1 GYS1 RAB34 TMEM59 MAP3K8 NCL PTMAP7 RHEB LAMC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 SDCBP GAS2L1 TNFRSF10B VCAM1 HMGA1 SLC4A10 NF2 TBCA CHMP2A SRPRB DKFZp761E1322 PICALM THBS1 ADAR SYNE2 TUBA1A FBXW11 SMAD1 CTDSP1 SIGMAR1 SEC23A HSD17B12 UBE2J1 DNAJB1 POLR2C SPTLC1 POLD2 TGFBR2 SH3BP4 ATP6V1C1 ATP6V1F GFPT1 PDLIM7 SLC12A2 GALNT7 GALNT1 ATP6V0E1 FMNL2 CPNE8 VEZT CUL4B BET1 PWP1 PNP DHX57 CIAO2A GOLGA7 FNDC3B FNDC3A PISD RTN4 POM121 HES1 MRPL20 COMMD9 SLC38A1 PEDS1-UBE2V1 MOV10 RARS1 ANP32B RNP24 NRP1 HEL-S-26 ARF4 TRAM1 HMOX1 MAGT1 MRC2 TMEM43 HOXA7 SH3BGRL3 TMED7 ANXA2 E2F3 ATP2A2 ELOVL5 AP2A1 PRPF40A YWHAQ CSDE1 FGF2 P4HA2 PXDN MRPS33 AKAP8 PPP1R7 MPZL1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MCAT HSD17B12 ACACA MECR OXSM HTD2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-117 ADH6 ALDH2 HEL-S-53e HEL-S-4 CYP2A6 CYP1A2 CYP1A1 CYP2E1 ADH1A ADH1C CYP3A4 CYP4A11 ADH7 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB NR1B3 RXRG RARA RXRA RARB DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 FST TGFB1 ANOS1 CELSR1 BMP4 SHH SPRY1 GRIP1 PAX2 SIX1 SMAD1 BMPER SMO GPC3 CRIM1 BMP7 BMP5 CTDNEP1 RARA HOXD11 FRAS1 HOXA11 FREM1 FREM2 GLI3 SALL1 ETV4 SIX2 BMPR1A BMPR2 NR1B3 EYA1 GDNF BMP2 CCND1 DCN RET ETV5 RARB HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis FECH UROD UROS HMBS CPOX ALAS1 ALAS2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex FLT3 GABPB1 BCL2L1 BCL2 SMARCA4 CREBBP ETV6 SMAD4 EP300 FOXO3A ZFX ATM GABPA PTEN TERF2 DNMT3B MCL1 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism ADSL PNP HEL-S-70p XDH AMPD1 APRT IMPDH1 ADA ADSS DGUOK HPRT1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling ITGB1 MAP4K1 MAPK8 PAK1 PTGS2 STAT3 CRK JUN DOCK1 SRC PIK3CA RAP1A HGF MAPK1 CRKL MAPK3 MET PTPN11 MAP2K1 MAP2K2 RAPGEF1 RAF1 PXN FOS PTEN ITGA1 PTK2B HRAS GRB2 SOS1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK1 TLR4 IRAK4 IRF7 MAPK8 MYD88 RELA CHUK TRAF3 RELB TRAF6 IKBKG IL10 MAP3K7IP1 NFKB1 IL6 CXCL8 TNF CCL4 ELANE MAPK14 NFKBIA TLR7 MAP3K7 IRF1 NFKB2 IKBKB LCN2 REL TLR8 CCL3 VCAM1 IL1A AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy DKFZp762B153 RB1CC1 WIPI2 ATG5 ATG14 AMBRA1 PRKAA2 RPTOR MTOR ULK1 PIK3R4 DEPTOR PRKAG1 MLST8 PRKAG2 ATG3 PRKAG3 PRKAA1 ATG9A ATG12 PRKAB2 ATG16L1 PRKAB1 AKT1S1 ATG101 UVRAG PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling P2RY11 ADORA2B GNAI1 P2RY6 P2RY4 P2RX6 GNAI3 P2RY2 P2RY1 PANX1 GNAS GNAO1 ADORA2A P2RY10 P2RY14 GNAZ P2RY8 GNAT2 GNAT3 GNAT1 LPAR4 P2RX7 P2RX5 GNA11 P2RX4 P2RX3 P2RX2 P2RX1 P2RY13 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions TLR4 NLRP3 MMP9 EGFR SMAD2 CNP EBI3 SIRPA FAM20C STAT1 PDGFA MBP CD47 IGF1 VEGFA TGFBR1 NKX2-2 IL10RA FOXO1 IGF1R MOG TYK2 PDGFRA OLIG1 CX3CR1 OLIG2 SOCS3 TNF CCL1 MAPK14 CTLA4 NKX6-1 CCL20 IL33 CSPG4 ITGB3 CD80 HEXB IL10RB IL12A CD68 NFKB2 IFNG STAT5B ITGA2 JAK3 OSM IL2RA IL2RB CD44 IL2RG MYD88 TGFB1 STAT3 CXCL12 TGFBR3 STAT4 IL12RB1 IL10 CCR8 FOXP3 NFKB1 HTR7 IL2 IL4 IL6 SPP1 NOS2 SOX9 PDCD1 CDC42 SSTR2 FOXO3A FOXO4 ROS1 ITGAV IKZF2 IL18 AIF1 CCN3 NKX6-2 TNFRSF1B IL1B KLRG1 RAC1 APOD MCAM JAK1 GSDMD TMEM119 TGFBR2 CXCL1 AREG CCR6 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome CDKL5 KCNJ10 XAB2 MEF2C TBL1XR1 IMPDH2 CHD4 HAP1 SCN8A HTT ACTL6B BRAF CRK SCN1A GABBR2 SCN2A HDAC5 HDAC8 SYNE2 GNAO1 NCOR1 STXBP1 NCOR2 SRRM3 SMARCA4 TAF1B FOXG1 HDAC1 SHANK3 SMARCA1 SMC1A TBL1X GRIN2B TCF4 SYNGAP1 EIF2B2 GABRA3 KDM5B TRRAP GPS2 RHOBTB2 CECR2 HIVEP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MEF2C MIXL1 MESP1 THY1 NKX2-5 NCAM1 INHBA SIRPA IGF1 ZFP42 BMP4 POU5F1 ISL1 INS KDR PDGFRA PAX6 NRG1 GATA4 SOX1 SOX2 MAPK14 TBXT NOTCH1 BMP1 CXCR4 MESP2 FOXA2 IGF2 TBX20 IRX4 TBX5 KIT MYL2 WNT3A TNNI3 GSK3B SOX17 SCN5A TGFB1 LIN28A LIN28B ROR2 DKK1 NODAL FGF2 NOG MYH6 MYLK3 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade SERPINB2 F13B PLAT KLKB1 PLG FGA VWF F2 HEL-S-78p KLNA1 F7 SERPINF2 F3 F5 F10 F8 F11 F9 WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling CAMK2A CCND2 DAAM2 PRICKLE2 GPC4 CAMK2G CTBP2 NFATC3 NFATC2 NFATC4 INVS WIF1 CCND3 MAP3K7 CCND1 MAPK9 MAPK8 FZD10 ROR2 FRAT1 FRAT2 CSNK2A1 CSNK2A3 NFATC1 CSNK2A2 CSNK1E DKK1 DKK2 DKK4 SFRP4 CSNK2B PPP3R1 PPP3R2 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 PPP3CA RAC1 PPP3CC PLCB4 PLCB1 PLCB2 DAAM1 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CHD8 RYK ROR1 WNT5B SOST LEF1 NKD1 NKD2 PRKCB DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 WNT3A VANGL1 KREMEN1 SENP2 SFRP5 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 ROCK2 JUN WNT16 NLK LRP5 LRP6 ARHA APC CTBP1 PLCB3 CAMK2D ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling CPT2 ME1 RXRB CD36 RXRG FABP4 DBI PLIN1 NR1C1 PDPK1 ANGPTL4 UCP1 RXRA APOA5 OLR1 APOC3 FADS2 SCD CYP7A1 APOA2 CYP27A1 PCK1 HEL-S-28 CYP8B1 PLTP FABP1 PPARG SLC27A5 LPL SLC27A1 EHHADH CPT1C NR1C2 UBC NR1H3 SLC27A4 CYP4A11 PCK2 ACSL1 ACOX1 AQP7 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling CAMK2A EGFR PAK1 NRG4 NRAS BRAF CAMK2G FOXO1 SRC SHC1 PDPK1 MYC AKT3 NRG1 HBEGF ERBB2 MAP2K4 NRG2 EIF4EBP1 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC4 SHC2 MAP2K1 SHC3 MAP2K2 TGFA BCL2L11 ERBB3 EGF RAF1 RPS6KB2 CDKN1B RPS6KB1 PRKCB PRKCA PIK3R3 PAK6 PAK4 STAT5B CCND1 GSK3B PIK3CD MAPK10 MAPK9 MAPK8 ARAF PLCG2 CRK JUN PIK3CA NRG3 CRKL BAD MTOR PIK3R2 PIK3R1 MDM2 CBL EREG BTC NCK2 NCK1 CDKN1A ABL2 HRAS CAMK2D GRB2 AREG SOS1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNT1 ACTA2 MYL3 TNNT3 MYH8 HEL113 MYL1 MYOM1 MYBPC3 TNNC1 TNNI1 ACTN2 DMD HEL-S-273 HEL-S-108 ACTN4 TTN ACTG1 tmp_locus_29 TPM3 TPM1 TMOD1 TCAP MYH6 ACTA1 MYL4 TNNI2 MYL2 TNNI3 TNNC2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 OXCT1 ACAT1 UCP2 BDH1 SLC25A20 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 SRD5A2 POR AKR1D1 AKR1C4 HSD3B1 SULT2A1 HSD17B3 CYP17A1 HSD17B2 AKR1C1 CYP3A7 AKR1C2 CYP3A4 HSD17B4 HSD17B1 HSD3B2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology HEL-S-15 ADCY3 ADCY1 SMAD2 ADCY8 SMAD4 ADCY6 WWTR1 TGFB1 LBR NRAS SYNE4 CTGF SYNE3 SUN1 YY1AP1 PLEC HEL-S-7a SYNE2 MAPK1 SYNE1 ARHA KRAS SOS2 MAPK3 TMEM43 HEL-S-61 MAP2K1 MAP2K2 BANF1 EMD ADCY9 LEMD3 HRAS GRB2 SOS1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m ERN1 ASNS NFE2L2 DNAJB11 BBC3 XBP1 SULT1E1 HEL-S-89n EIF2A EDEM1 HEL-S-99n DNAJC3 ERP27 TRIB3 DDIT3 DNAJB9 UBE2E1 PPP1R15A BCL2L11 NARS1 ATF3 ATF4 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL SMAD2 PARP1 SMAD4 TGFB1 PPARG FBN1 ZMPSTE24 FNTA BANF1 LMNA INS KCNJ6 MUCL3 SPRTN ICMT LMNB2 WRN FFAR3 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1A2 CAMK2A NPPB CASP9 PDE3A RELA PBR GUCY1B1 CAMK2G GRIN1 NFKB1 CNGB1 ACTN2 DLG4 CNGA3 CNGA4 AKAP9 TNF CNGB3 NEFL NOS2 PDE2A BAD NFKBIA CALM1 BCL2 NPPA GRIN2B IFNG CREB1 IL1B CNGA1 CAMK2D CYCS AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG2 PRKAG3 PRKAA1 SIRT1 PRKAB2 RPS6KB1 PRKAB1 PRKAA2 PMAIP1 PPARGC1A MAPK3 RPTOR HEL-S-32 MTOR PARP2 PRKAG1 MLST8 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA ACTA2 SMAD2 CASP9 SMAD4 CASP3 BAK1 TGFB1 APAF1 TRPV5 BAX BRAF TGFBR1 PDE1B TNFRSF1A PIK3CA MAPK1 CASP8 SEC16B MAP3K5 HEL-S-41 MTOR FFAR3 PPP3R1 RAF1 TNFSF11 PTH MCU FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP9 MAPK8 PAK1 CASP3 APAF1 CASP10 FAF1 MAP3K1 JUN DFFB MAPKAPK3 DFFA FAS ARHGDIB LMNB2 MAP2K4 TNF CASP8 RIPK2 NFX1 SMIM40 PRKDC BCL2 FADD PARP1 ACTG1 SPTAN1 TNFSF6 CASP6 PS1TP5BP1 LMNA MAP3K7 ACTA1 RB1 HEL-S-102 MAPKAPK2 CYCS IL1A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network ADORA2B BTG2 AURKA PML ZMAT3 PERP LIF ISG15 FAS CX3CL1 TP53I3 CDK2 PRKAA2 TNF GPX1 CCL2 RPTOR SMR3B DEPTOR ACAD11 SERPINB5 PRKAG1 MLST8 SCO2 PRKAG2 ADGRB1 NOTCH1 DRAM1 RPRM SIVA1 MGMT ULBP2 PRKAG3 ULBP1 SESN2 PRKAA1 BBC3 TP53AIP1 IRF9 PIDD1 TNFSF6 DDIT4 SESN1 TIGAR FUCA1 PRKAB2 CPT1C PRKAB1 AKT1S1 SLC7A11 DDB2 RRM2B PMAIP1 TNFRSF10B TRAF4 CCNG1 POLK TSC2 XPC ERCC5 APAF1 BAX SFN MSH2 THBS1 FANCC ULK2 ULK1 MTOR GADD45A PCNA TNFRSF10D NCF2 CCNE1 E2F7 CDKN1A PTEN GLS2 TP53INP1 XRCC5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap MAT1A CDO1 ADK MTR CTH HEL-S-182mP HEL-S-61p CBS BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 SST FOXO1 SFRP1 DKFZp781O1323 CTNNB1 DKK1 WNT4 SMAD1 BMP2 DCN LEFTY2 BCL2L11 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CA HLA-DRB1 PIK3CD PIK3R3 CD80 PPP2CA PTPN11 CTLA4 PTPN6 PIK3R2 PIK3R1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT1 HEL-S-277 PRMT7 NOS2 CARM1 PRMT3 PRMT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 HGS RAF1 ARAF PDCD6IP BRAF NRAS RAB5B RAB5C RRAS2 RRAS MAPK1 KRAS RAB27A MAPK3 HRAS RAB5A IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BIRC5 TGFB1 RELA CHUK STAT1 STAT3 RUNX2 PIAS1 SRC TYK2 PDPK1 SOCS3 IL11 MAPK1 IL11RA BGLAP FYN MAPK3 ATF1 PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2 YES1 RAF1 FES RPS6 RPS6KA1 RPS6KB1 IBSP PTPA IKBKB CREB1 JAK1 HRAS ITGA2 GRB2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COX11 ERBB2 MAPK1 ADRA2B ARHA MAPK3 CIAO2A ANKRD23 SNRNP200 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 DUSP2 CNNM4 FER1L5 STARD7 SEMA4C ARID5A COL2A1 ASTL NEURL3 ZP2 KANSL3 PLXNB2 MMS19 IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling GSK3B SPRED1 STAT1 STAT3 JUN SHC1 IL2 IL5RA MAPK1 CSF2RB KRAS MAPK3 PTPN11 MAP2K1 LYN MAP2K2 PIK3R2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 RPS6KA1 RPS6KB1 GSK3A JAK1 STAT5B BTK GRB2 SOS1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP3 CARD9 CARD6 ACAP1 NLRP10 NOD2 CASP9 NLRP7 NLRP2 NLRP12 RELA CHUK IKBKG NLRP1 NAIP CASP8 DUOX2 CASP5 RIPK2 NFKBIA NDUFA13 PRDM1 AIM2 PYCARD COPS6 IL18 IKBKB IL1B RAC1 NOD1 NLRC4 MEFV AAMP CARD8 ERBIN LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PDE3B RELA SH2B1 STAT1 CISH FOXO1 SRC SHC1 SOCS2 SOCS3 IRS1 ERBB2 PRKAA2 EIF4EBP1 MAPK1 FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 MAP2K2 EIF4E SOCS7 ACACA RAF1 PRKAA1 RPS6 LEPR RPS6KB1 ACACB REL STAT5B CFL2 KHDRBS1 GSK3B LEP KPNA4 MAPK8 CHUK STAT3 PLCG2 IKBKG ROCK1 PLCG1 ROCK2 NFKB1 SP1 ARHA BAD MTOR PIK3R2 PIK3R1 CDC42 RPS6KA1 GSK3A PTEN IKBKB CREB1 RAC1 JAK1 HRAS GRB2 NCOA1 SOS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC1H1 DYNC2H1 DYNLRB2 IFT46 DYNLT1 IFT140 DYNC1LI2 IFT81 DNCL1 DYNLT3 IFT80 WDR35 IFT27 DYNLL2 IFT25 IFT43 DYNC1I1 DYNLT2B IFT22 DYNC1LI1 DYNC2I2 DYNC2LI1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine HEL-S-7a ADRB1 ADCY3 ADCY1 ADRB2 ADCY8 ADCY6 ADCY9 ADRA2C ADRA2B ADRA2A ADRA1D PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCC2 CYP24A1 ABCD2 CYP26A1 NR1C1 CYP27B1 CYP3A4 NR1I3 NR1i1 ABCG5 CYP7A1 ABCD3 NR1i2 NR1H4 CYP8B1 RARA CYP2C9 PPARG ABCB4 CYP2B6 CYP1A2 ABCB1 ABCA1 CYP2E1 ABCC3 CYP4B1 NR1C2 ABCG1 ABCB11 NR1B3 NR1H3 CYP4A11 RARB HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA2 PDHA1 ACACA NFE2L2 PRKAA1 RPS6 VEGFA PRKAB1 ACACB EGLN1 HIF1A HEL-S-133P SLC11A2 PRKAG1 KEAP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 AKR1D1 AKR1C1 AKR1C4 AKR1C2 CYP3A4 CYP11B2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTC4S DECR2 ALOX5 ABCC1 ALOX5AP PTGR1 DECR1 CYP4F3 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX VLDLR NDEL1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP HIST1H2BE CDKN2A FZR1 RPS6KA2 RELA CEBPB UBE2D1 EHMT1 CDK4 RPS6KA3 CDK2 MAPK1 MAPK3 H2BC21 H2AX CDKN1B UBB ANAPC1 CCNA2 RPS27A CDKN2D CDKN2B CDKN2C H3C8 CDC26 STAT3 VENTX ANAPC15 C10orf104 UBE2S CDC27 JUN UBE2C MAPK7 NFKB1 H3C15 IL6 CXCL8 CDK6 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 RPS6KA1 H2BC8 CDC23 H4C9 H2AC6 HIST1H4L ANAPC7 FOS H2BC3 ANAPC5 UBC H2BC1 CDKN1A ANAPC2 H2BC17 H3F3B H2BC12 ANAPC11 H2BC13 H2AJ H2BC14 UBE2E1 H2BC15 IGFBP7 H2AC20 H2BC11 IL1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways NADSYN1 TDO2 NMNAT1 IDO1 PARP4 PARP1 NAPRT NAMPT BST1 SIRT1 SIRT3 TNKS2 SIRT6 SIRT4 HEL-S-90n SIRT5 SIRT7 TNKS PARP2 SIRT2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HEXA HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB GLB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases MMP16 MMP9 MMP15 MMP23B MMP17 MMP19 TCF20 MMP26 TNF TIMP4 TIMP3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 hEMMPRIN MMP7 MMP2 MMP3 MMP10 MMP12 MMP11 TIMP1 MMP14 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 SMAD4 BMP6 RUNX2 IGF1 BMP4 DKFZp781O1323 BHLHE41 HMGB1 CSF1 PRKAA2 CTF1 LAMP2 NOTCH1 BCL2 CRY1 ATG3 BMP5 SP7 SOST ATG12 PTH TNFRSF11B CTSK ATG16L1 ATG101 PLEKHM1 CTHRC1 MAP1LC3A SQSTM1 ATG10 BMP2 PER1 CALCA LEP DKFZp762B153 RB1CC1 TGFB1 TRAF6 WNT16 VCP RORB NFATC1 BMP3 ATG5 DKK1 IL6 LRP5 AMBRA1 ARHGAP4 FYCO1 DRAM2 SMAD1 SEMA4D ULK1 MTOR IL3 SEMA3A SMAD9 TNFSF11 WNT10B EFNB2 BHLHB2 TNFRSF11A NPAS2 BMPR2 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity PCNA KDR BDKRB2 CYP3A4 MAPK1 PTK2B HEL-S-44 MAP2K1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 ABCC2 CYP2C9 UGT1A3 CYP2A6 CYP2B6 SULT2A1 DNAJC7 UGT1A1 ABCB1 UGT1A9 FOXO1 ABCC3 SRC SLCO1B1 UGT1A4 CYP2C19 CYP3A7 CYP3A4 RXRA PPARGC1A SRPX2 CYP4F12 NCOA1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKD3 ADCY3 ADCY1 PDE4A ADCY8 ADCY6 GNA14 GNG3 GNG5 GNG4 NRAS GNG7 GNG8 PDE1C AKAP5 PDE1B AKAP10 PDE1A PDE8A AKAP9 KRAS PDE7B PDE7A GNAZ PRKACG PRKCH PRKCB GNG10 GNA11 PRKCE GNGT2 PRKCA ADCY9 PRKAR1B GNAL PRKAR1A PRKCI PRKCQ PRKD1 PRKCZ GNAI1 GNAI3 GNG12 GNG11 GNG13 KCNJ3 GNA15 RRAS GNB2 ARHA GNB1 GNAS HEL159 GNB3 AKAP12 GNAO1 AKAP11 GNB5 AKAP7 AKAP6 CALM1 AKAP4 GNGT1 PDE4B PDE4D ARHGEF1 AKAP8 GNA13 PLCB3 PPP3CA PPP3CC HRAS ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling CHEK1 RAD9A MAPK9 TP73 MRE11A MDC1 IKBKG JUN CASP2 RAD50 TP53BP1 RAD51 CDK2 CRADD ATF2 GADD45A MDM4 H2AX PIDD1 MDM2 CCNE1 ATM TLK1 NBN RIPK1 SMC1A CDKN1A BRCA1 CCNB1 CREB1 CDC2 CHEK2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 FADD CASP9 CASP3 APAF1 TNFSF6 CASP6 MAP3K1 TNFRSF1A CASP2 RIPK1 NFKB1 FAS CASP8 AIFM1 CYCS PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC35B2 CANT1 BPNT2 PAPSS2 CHST3 XYLT2 XYLT1 CHSY1 CSGALNACT1 B3GAT3 SLC26A2 B3GALT6 EXT2 CHST14 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP1 AXIN1 TNK2 TNK1 BTRC SKP1 DVL1 CTNNB1 DVL2 RBX1 DVL3 PARP10 APC PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection HLA-DQA2 HLA-DQA1 HEL113 STAT1 VEGFA HLA-DRB1 FAS PDGFRA HLA-B HLA-F CCL19 HLA-G TNF HLA-DOA HLA-E HLA-DRA HLA-DOB CTLA4 AGTR1 HLA-DPA1 HLA-DQB1 CCL21 HLA-DMB C1QB HLA-DPB1 C1QA CD40 LRRK2 TNFSF6 CD80 C4B_2 C2 C4A C8A IL12B IL12A CXCR5 HEL-S-62p CD40LG IFNG GDNF HARS1 IL17A IL2RA C1QC IF2B1 HLA-DRB5 CASP9 PRKCZ IL-21 CASP3 TGFB1 HLA-DMA CXCL12 PRF1 IL10 IL13 CSNK2A2 FOXP3 HLA-A IL2 IL4 IL5 TUBA1B CXCL8 C6 C7 CASP8 HLA-C C9 CD55 GNLY BHMT2 PECR ABCB1 GABPA IL1B MICA CXCL9 CXCL13 CXCL11 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome SNRPN NUP133 CDKN2A CCND2 PCM1 NUP98 RAE1 BDNF INS CDK4 DLX5 HEL-S-71 MSX1 HERC2 EIF4E TACR3 POM121 RNF8 PCSK1 RB1 CDKN2B CDKN2C CCND1 GHRH BBS4 GHRL PRKCZ AHCTF1 KISS1 UBE3A TUBGCP5 NIPA1 NDN TUBGCP6 TUBGCP4 NIPA2 FSHB GABRG2 SNURF ATP10A NUP85 TPR LHB CGA NUP107 CDK6 MDM4 POMC OXT NUP62 GNRH1 NUP188 NPAP1 NUP214 NDC1 MAGEL2 MDM2 GOLGA8S NUP88 GABRB3 NUP210 CYFIP1 GOLGA6L2 GABRR3 NUP93 FEZ1 FMR1 GABRR1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 GABRA5 NGF SEH1L AAAS GABRG3 NUP160 GABRG1 NHLH2 NUP42 RANBP2 NUP155 CDC6 NUP153 TYR NUP35 MKRN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway COL1A1 LAMA5 LAMB2 COL3A1 IL2RG ZAP70 TNFRSF1A THBS1 IL2 IL4 VTN IL5 IL5RA COL1A2 LAMB1 CD40 CD80 LAMC2 LAMC1 CD40LG IFNG TNFRSF1B LCK THBS3 IL2RA IL2RB GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG8 ALG9 ALG2 TUSC3 ALG14 ALG13 ALG3 B4GALT1 ALG12 ALG11 DPM3 DPM2 GCS1 DPM1 MAGT1 ALG1 ALG6 MGAT2 SRD5A3 DOLK DPAGT1 MPDU1 GMPPB CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CALM1 ATP2A1 HDAC2 CD8B1 MEF2D EP300 HDAC1 CD8A CABIN1 PLCG1 ZAP70 PPP3CA PPP3CC NFATC2 LCK ITPRIP RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway RS1 ANGPT4 BIRC5 ANGPT2 TNIP2 ITGB1 TNIP3 EGFR ANGPT1 PAK1 RELA NRAS GRB7 FOXO1 SRC RAD51 CTNNB1 MYC ERBB2 EIF4EBP1 MAPK1 MAPK12 KRAS MAPK3 MAPK13 PTPN11 MAPK11 MAPK14 NFKBIA GRB14 PXN STAT5B CASP9 MAPK9 MAPK8 CHUK STAT3 BAX YAP1 CRK IKBKG MSH2 PIK3CA NFKB1 NOS2 BAD PIK3R1 NCK1 IKBKB MMP2 RAC1 HRAS GRB2 SOS1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 NOP2 CDKN1B FLT1 FOXO3A GAB2 ABCB1 LYL1 SKP2 PDGFRA CSF1R MYC ABCG2 KIT BCR GADD45A CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EGFR CREBBP KDM5C EFCAB3 FLT1 PBRM1 EP300 SDSL PGBD5 LDHD VEGFA PSAT1 CAMK1 PSPH ENO1 KDR KSR1 HEL-S-68p SETD2 BHLHE41 PDGFRA HEL-S-30 SSPN RPTOR PHGDH DEPTOR MLST8 ACACA FASN HEL-S-51e GRB10 RHEB BAP1 AKT1S1 LDHB SQSTM1 ACACB HIF1A HEL-S-133P HK3 HEL-S-32 CEP290 KCNJ2 ME1 PGM2 MAP2K5 TSC2 TSC1 STAT3 HEL-S-162eP PFKL ACLY ENO2 PFKM ENO3 PLOD2 PFKP HEL-S-49 HEL-S-87p ENPP3 HK2 VHL MTOR RAPGEF5 PKLR ALDOB SHMT1 PTEN HALLMARK_P53_PATHWAY%MSIGDBHALLMARK%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY CYFIP2 RB1 APP CCNK STEAP3 CD82 HEL-S-130P CD81 DGKA RNF19B CCP110 ABAT TM7SF3 IFI30 RRP8 CCND3 CCND2 SESN1 RPL36 FDXR FOXO3A NUDT15 IER5 TP63 PHLDA3 RPS12 TSPYL2 TNLG5A FBXW7 F2R DNTTIP2 IRAG2 TRAFD1 TAP1 CGRRF1 PRKAB1 TM4SF1 PROCR MAPKAPK3 DDIT3 DDIT4 NINJ1 TXNIP S100A4 TRIB3 NUPR1 ANKRA2 ISCU ATF3 EPHA2 POM121 NOTCH1 ABHD4 RETSAT SLC35D1 RRAD AK1 HSPA4L TGFA PDGFA XPC KLK8 CDKN2AIP LDHB NHLH2 SOCS1 IRAK1 ZMAT3 CLCA2 HMOX1 SFN IP6K2 SLC19A2 S100A10 HEXIM1 JAG2 PLK3 JUN ST14 TGFB1 PMM1 GADD45A FUCA1 PLK2 ZBTB16 EPHX1 OSGIN1 LIF INHBB ALOX15B H1-2 PTPRE BMP2 H2AC25 TCN2 SP1 MDM2 SDC1 PLXNB2 MXD1 FGF13 ADA MXD4 RAD9A CSRNP2 BTG2 CDKN1A BTG1 ITGB4 TCHH IKBKAP TRIAP1 SLC7A11 PITPNC1 PIDD1 SEC61A1 HINT1 GM2A KIF13B CTSF WDR8 HRAS ZNF365 GPX2 APAF1 PRMT2 ABCC5 SPHK1 DCXR RHBDF2 VWA5A AEN FOS SERPINB5 DDB2 VAMP8 IL1A H2AJ RAP2B RAD51C TRAF4 TAX1BP3 HBEGF PPP1R15A CEBPA HDAC3 PCNA GLS2 RGS16 EI24 NOL8 RPS27L SLC3A2 ACVR1B RCHY1 PPM1D TOB1 SERTAD3 DRAM1 RXRA RAB40C PERP TNNI1 STOM EPS8L2 BAK1 RPL18 CDKN2B NR1i1 CDKN2A TPRKB WWP1 BAIAP2 KLF4 TPD52L1 BLCAP DEF6 CCNG1 BAX FAS ERCC5 COQ8A CDK5R1 HALLMARK_MITOTIC_SPINDLE%MSIGDBHALLMARK%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE HCTP4 CCNB2 RHOT2 BCL2L11 KIF3B CEP72 STK38L CEP192 KIF3C ECT2 MARK4 MYH10 SPTBN1 SAC3D1 PLK1 TBCD ARHGAP29 ARHGAP27 HOOK3 SSH2 CDC2 NET1 NF1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 TOP2A DOCK4 NUMA1 KIF11 WASL ARHGAP5 BRCA2 KIF15 ARHGAP4 SEPT9 PCM1 CAPZB CNTRL NCK2 TLK1 KIF1B SPTAN1 DLGAP5 NCK1 ARHGEF11 PLEKHG2 ARHGEF12 DST RFC1 SHROOM2 KIF23 SHROOM1 RHOF SMC1A CKAP5 DYNLL2 LATS1 ARHGAP10 ESPL1 INCENP PALLD CDC42EP4 RASA2 ARHGEF3 CDC42EP2 CDC42EP1 MYH9 BIRC5 ARHGEF2 ARHGEF7 MAPRE1 RAPGEF5 SOS1 DOCK2 RAPGEF6 PAFAH1B1 ARF6 KNS2 STAU1 ROCK1 KATNB1 TUBD1 NEDD9 TTK HDAC6 AURKA HEL-S-47e CDC42 CYTH2 FGD4 FGD6 KATNA1 FLNA RICTOR FLNB PCNT WASF1 WASF2 CLASP1 ARFGEF1 DYNC1H1 FARP1 PCGF5 MID1IP1 RANBP9 MYO9B CDC42BPA LRPPRC MYO1E CENPE MARCKS CENPF APC PRC1 ALMS1 TAOK2 RAB3GAP1 HEL2 TRIO HEL114 SMC3 SMC4 UXT PREX1 PPP4R2 OPHN1 CDC27 NUSAP1 CEP250 NEK2 KNTC1 FBXO5 KIFAP3 SYNPO CDK5RAP2 HEL-S-61 RALBP1 KNTC2 MAP1S CEP131 CSNK1D TSC1 ACTN4 MID1 TUBA4A CD2AP BCR CLIP2 TIAM1 BIN1 KIF20B EZR ARL8A LLGL1 NOTCH2 PIF1 CPAP PXN HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDBHALLMARK%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION NT5E ABI3BP GPC1 SPP1 SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 CAP2 CTHRC1 PRRX1 VEGFC VEGFA MFAP5 COL3A1 FAP MGP PMP22 PTX3 CRLF1 SNTB1 DST FLNA JUN TGFB1 GADD45A FUCA1 OXTR COL16A1 SPARC SERPINE2 WIPF1 COL12A1 TNC HEL113 PLOD3 SDC1 PLOD2 PLOD1 HEL-S-273 ENO2 FGF2 LOXL1 CTGF LOXL2 MYLK COMP CDH6 RGS4 DKFZp686P11128 GJA1 CDH2 BASP1 DPYSL3 PRSS2 POSTN IGFBP4 APLP1 IGFBP2 TPM1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A2 COL4A1 ADAM12 COL8A2 PPIB MXRA5 SCG2 PFN2 FBN2 COPA NNMT SDC4 NTM HTRA1 TNFRSF11B THY1 FBLN2 NID2 FBLN5 CALD1 QSCN6 VCAM1 CADM1 MAGEE1 GADD45B BDNF TFPI2 FZD8 INHBA COL1A1 IL6 BMP1 COL1A2 CXCL12 SLC6A8 COL5A3 ID2 COL5A2 CALU SNAI2 TGFBI FERMT2 FBN1 ITGB1 CXCL6 CXCL8 ECM2 ITGB5 MCM7 ITGB3 TNFAIP3 FAS LAMC2 CXCL1 LAMC1 AREG CYR61 GLIPR1 SGCD SGCB TIMP3 ITGAV HEL-S-108 TIMP1 COLGALT1 EDIL3 SGCG TNFRSF12A IL15 ITGA2 MMP2 MMP3 PLAUR GPX7 EMP3 DCN RHOB ACTA2 GREM1 TGFBR3 VCAN MMP14 CDH11 TMEPAI GAS1 MATN3 CD44 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 NOTCH2 THBS1 FSTL1 PTHLH FSTL3 HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDBHALLMARK%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING CDKN1A CDC2 ATF1 HEL-S-71 GSK3B HRAS ARF1 CDKN1B CLTC UBE2D3 PRKAG1 PTEN SLA ECSIT HEL-S-125m GNGT1 RPTOR RPS6KA3 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 MAP3K7 AP2M1 VAV3 MAP2K3 NCK1 ACTR3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 FGF7B IRAK4 NGF TNFRSF1A LCK AKT1S1 CSNK2B PLCB1 PFN1 RAF1 SQSTM1 PRKAA2 RALB CAB39 MAPKAP1 ITPR2 CXCR4 DDIT3 PIK3R3 DAPP1 NOD1 FGF6B IL2RG TRIB3 HEL-S-99n EGFR ACACA HEL-S-15 GNA14 MAPK9 MAPK8 ADRBK1 MAPK1 RIPK1 PLCG1 EIF4E FGF22 MAP2K6 HEL-S-47e PAK4 SMAD2 STAT2 PTPN11 MAPK10 IL4 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 SFN CDK2 PIN1 GRB2 MYD88 NFKBIB TIAM1 HALLMARK_GLYCOLYSIS%MSIGDBHALLMARK%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS NT5E PSMC4 CTH GPC1 AGRN POLR3K PFKP VEGFA CDC2 CXCR4 DDIT4 EGFR AURKA TGFA ERO1A HEL-S-278 CHPF HEL-S-75 ZNF292 XYLT2 ENO1 HS6ST2 HEL-S-89n DPYSL4 CAPN5 NDST3 PDK3 SOX9 SLC16A3 IL13RA1 RARS1 HEL-S-304 GLCE COG2 SDHC ALG1 MIF SDC1 PLOD2 PHKA2 PLOD1 SAP30 TPST1 ENO2 CLDN3 CLDN9 RRAGD PKP2 KDELR3 RBCK1 KIF20A FKBP4 ALDH7A1 DSC2 GNE COPB2 PFKFB1 PAXIP1 ABCB6 GPR87 SDC2 SDC3 STC1 AK3 AK4 TXN HMMR ARPP19 CACNA1H FUT8 CHST12 STC2 RAA1 NDUFV3 ANKZF1 LHPP HOMER1 HEL-S-165mP ECD GFPT1 GOT2 SRD5A3 HEL-S-133P B3GALT6 EXT1 ISG20 EXT2 EFNA3 GCLC P4HA1 NASP ARTN QSCN6 P4HA2 HEL20 GALK2 LHX9 PYGB B4GALT1 HEL-S-32 CITED2 HEL-S-30 PYGL VLDLR HK2 HS2ST1 HEL-S-69p GMPPB GYS2 GYS1 NANP CASP6 ME1 TGFBI PGM2 ME2 SLC37A4 GUSB MIOX CHST6 CHPF2 PGAM1 PGAM2 HEL-S-68p HEL-S-26 HEL-S-19 HAX1 MED24 ELF3 ADORA2B B3GNT3 TFF3 DEPDC1 CHST1 SLC25A10 ANGPTL4 ALDOB CHST4 LCT DLD MET B4GALT4 FBP2 SLC25A13 ALDH9A1 HEL-S-87p IDUA RPE DCN GLRX NOL3 CENPA CLN6 MXI1 VCAN GPC3 GPC4 EGLN3 SLC35A3 B3GAT3 MDH2 CD44 BIK AGL TPBG B3GAT1 SPAG4 HEL-S-44 MERTK HEL-S-49 GNPDA1 PC HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDBHALLMARK%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING HDAC5 HDAC2 MAML1 HDAC11 LEF1 PSEN2 RBPJ NR1C2 NKD1 GNAI1 FRAT1 MYC HEY2 DVL2 NOTCH1 SKP2 WNT1 FZD1 WNT5B PTCH1 AXIN1 AXIN2 CSNK1E DKK4 DKK1 NCOR2 ADAM17 KAT2A NUMB CTNNB1 JAG2 CCND2 FZD8 HALLMARK_SPERMATOGENESIS%MSIGDBHALLMARK%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS CCNB2 CDC2 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 PIAS2 ZPBP ADAM2 ZC2HC1C MTNR1A SCG5 VDAC3 SCG3 HOXB1 STAM2 TSSK2 CFTR DPEP3 DDX4 ALOX15 ART3 OAZ3 FLJ13057 PGS1 PCSK1N NPHP1 IP6K1 ZC3H14 RPL39L GSTM3 PDHA2 ODF1 BRAF HSPA2 SNAP91 H1-6 TUBA2 RAD17 PSMG1 NF2 CNIH2 SPMAP2 EZH2 SYCP1 MAST2 HEL-S-34 IDE COIL TTK SHE HSPA4L HEL162 AURKA GRM8 GSG1 TOPBP1 NEFH HBZ PACRG RFC4 NPY5R DCC PARP2 ELOVL3 SIRT1 CAMK4 MLF1 TSN ARL4A DBF4 MEP1B DMC1 HEL-S-278 ACRV1 TULP2 CST8 AKAP4 ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A CHFR MTOR POMC TNP2 LPIN1 TNP1 CDKN3 ACKR5 NEK2 HALLMARK_APOPTOSIS%MSIGDBHALLMARK%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS CTH RHOT2 BCL2L11 LEF1 PSEN2 CDKN1B TOP2A CTNNB1 APP SPTAN1 CCND2 FDXR F2R SQSTM1 TAP1 DDIT3 TXNIP ATF3 ROCK1 RETSAT NEDD9 NEFH TNFSF6 HMOX1 CDK2 JUN GADD45A BMP2 IFITM3 PRF1 PLAT ENO2 CLU TNF CCND1 TNFSF10 BTG2 BNIP3L CDKN1A HGF CDC25B EREG FEZ1 MADD DAP3 DIABLO PSEN1 BCL10 EBP PPP3R1 BCL2L10 ANKH PMAIP1 BMF CD14 IGFBP6 MCL1 CREBBP GSTM1 H1-0 IGF2R CYLD DAP PPT1 BCL2L2 BCL2L1 BTG3 HMGB2 BRCA1 IL1A CASP9 CASP8 CASP3 CASP4 CASP2 ISG20 PBR HEL-S-102 DFFA GPX1 ANXA1 GPX4 GPX3 IFNGR1 IL18 PPP2R5B EMP1 GADD45B AVPR1A F2 DNAJC3 HEL-75 IRF1 IL1B IL6 DPYD RARA ETF1 PLCB2 BIRC3 RNASEL GUCY2D SATB1 CASP6 SLC20A1 PLPPR4 RELA ADD1 GNA15 PAK1 ERBB3 ERBB2 LMNA SC5D BCAP31 IFNB1 BAX MGMT FAS CD2 WEE1 KRT18 CD69 TIMP3 TIMP1 TNFRSF12A MMP2 DCN RHOB TGFBR3 CD44 BIK HEL-S-44 HALLMARK_COMPLEMENT%MSIGDBHALLMARK%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT MAFF GNB4 CALM1 CPM SERPINA1 DYRK2 CD59 ITGAM CPQ DOCK9 PLEK PCSK9 CTSS CTSO AKAP10 GNGT2 PCLO CASP5 CASP10 CTSL KYNU CTSH KLNA1 OLR1 CD36 HEL-S-7 CTSC DUSP5 CR2 SERPINB2 CR1 DOCK4 FCER1G GP1BA APOA4 SIRT6 F3 ADRA2B F5 MMP12 HEL-S-130P HEL-76 F7 F8 PLSCR1 PIK3CA MMP15 IRF2 IRF7 LCP2 CD46 L3MBTL4 C1QA USP14 CEBPB SCG3 USP15 USP16 C1S C1R SERPINC1 TMPRSS6 LCK SRC WAS GNAI3 PLG PFN1 PRCP RAF1 RNF4 PPM2C GNG2 SPOCK2 CCL5 FYN SH2B3 CD55 F10 GCA HEL-S-62p KCNIP3 GZMA ATOX1 ARHG GZMK CD40LG XPNPEP1 APOC1 KLKB1 C1QC MSRB1 GRB2 HEL-S-89n PLAT CLU PSEN1 COL4A2 RAA1 CASP9 CASP3 CASP4 F2 TFPI2 IRF1 IL6 ME1 TNFAIP3 CXCL1 CDK5R1 DGKG FCN1 CDA GMFB C4BPB LIPA NR2A1 DOCK10 TIMP1 LAMP2 PIM1 ACTN2 HPCAL4 GPD2 FDX1 ADAM9 SERPING1 LAP3 PLAUR S100A9 CFH GATA3 PLA2G7 PIK3R5 C2 DPP4 VCPIP1 PPP4C MMP14 C9 S100A13 S100A12 RCE1 STX4A LYN APOBEC3F APOBEC3G BRPF3 CP MT3 EHD1 GP9 GNB2 HALLMARK_E2F_TARGETS%MSIGDBHALLMARK%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS CCNB2 PLK1 MYC CDC2 CDKN1B TOP2A BRCA2 CCP110 DLGAP5 RFC1 SMC1A ESPL1 BIRC5 EZH2 DCLRE1B JPT1 NUP107 POP7 TFRC AURKA DSCC1 BUB1B SMC6 MKI67 CDC20 PNN PTTG1 WDR90 CHEK2 CHEK1 NBN CDK4 LIG1 HUS1 ILF3 DDX39A MSH2 CCNE1 MTHFD2 ZW10 TIMELESS ASF1A ASF1B SNRPB SLBP CENPE NUP205 RNASEH2A CDCA3 PRKDC SHMT1 AK2 CDCA8 NOLC1 PDS5B RAD51AP1 ORC6 UBR7 RAD21 ORC2 LYAR BARD1 CDKN3 PLK4 HEL25 HMGA1 NUP153 PA2G4 EIF2S1 PAICS PAN2 POLA2 CDKN1A STAG1 CDC25B KIF18B UBE2S UBE2T ANP32E HNRNPD MXD3 H2AX HEL-S-97n SUV39H1 HMGB3 PSIP1 CTCF CKS1B CROP ING3 HMMR MYBL2 TK1 LBR POLE TCF19 HELLS RFC3 RFC2 EED TUBB CTPS1 TUBG1 HMGB2 CIT BRCA1 MMS22L CKS2 MCM3 RAD51C MCM5 NAA38 MCM6 DCTPP1 MCM2 PRIM2 AURKB PCNA UNG NASP POLD3 PSMC3IP TRA2B EXOSC8 POLD2 PPP1R8 USP1 PMS2 PPM1D RBBP7 E2F8 GINS1 H2AZ1 NOP56 RANBP1 DUT CDKN2C RRM2 SPAG5 GINS3 ATAD2 GINS4 DONSON CDKN2A RPA1 MRE11A SSRP1 DEK POLE4 NUDT21 RAD50 PHF5A MCM7 RPA3 BRMS1L RQCD1 TACC3 WEE1 CENPM RAD1 TRIP13 RAN SPC24 SMC3 MAD2L1 SMC4 DEPDC1 SPC25 HALLMARK_G2M_CHECKPOINT%MSIGDBHALLMARK%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT HCTP4 TNPO2 CCNB2 SS18 RBM14 HEL-S-72p HEL164 H2BC12 CCNA2 SLC7A5 SFPQ RBL1 TFDP1 DTYMK DKFZp666G145 SLC7A1 PLK1 HIRA PURA MYC WRN CDC45 NSD2 E2F2 CDC2 DMD E2F3 E2F4 SRSF10 GINS2 CASP8AP2 H2AZ2 CDKN1B POLS EGF TOP2A MAPK14 PML NUMA1 CUL4A KIF11 MEIS1 pk BRCA2 KIF15 KIF23 SMC1A ESPL1 INCENP BIRC5 PAFAH1B1 EZH2 JPT1 TTK AURKA MKI67 CDC20 KATNA1 PTTG1 CHEK1 CDK4 HUS1 ILF3 DDX39A DBF4 TGFB1 CENPE MARCKS CENPF SLC12A2 PRC1 NOLC1 PDS5B ORC6 RAD21 BARD1 CDKN3 PLK4 SAP30 HMGA1 CCND1 POLA2 STAG1 CDC25B UBE2S HNRNPD H2AX SUV39H1 HMGB3 CTCF CKS1B HMMR MYBL2 LBR POLE CKS2 MCM3 MCM5 MCM6 MCM2 PRIM2 AURKB NASP TRA2B H2AZ1 CDKN2C TACC3 MAD2L1 SMC4 ARID4A SMC2 MT2A RPS6KA5 SNRPD1 CDC27 NUSAP1 HMGN2 TLE3 NEK2 SLC38A1 SMARCC1 FBXO5 PRP4K KNL1 TRAIP DKC1 HEL-S-61 EWSR1 NCL KNTC2 NUP98 ATF5 CUL5 CENPA YTHDC1 TROAP EFNA5 HIF1A STIL UBE2C CBX1 FANCC CDC6 FOXN3 KIF20B SQLE UCK2 MNAT1 SETD8 NOTCH2 AMD1 HOXC10 CHAF1A CHMP1A HALLMARK_FATTY_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM CD36 ACSM3 ECI2 AQP7 CPOX UBE2L6 HEL-76 ENO3 IL4I1 TDO2 HEL-S-53e UROD MLYCD PIG59 ACOT8 CPT1A GABARAPL1 MIX23 ACSL1 ACSL5 SDHD SDHA ALDH3A2 ALDH3A1 GPD1 SMS SUCLG2 SUCLG1 GCDH IDI1 SLC22A5 MAOA CD1D ADH7 ADIPOR2 ACAT2 NTHL1 RDH11 HAO2 DECR1 PDHA1 NCAPH2 UROS CIDEA DHCR24 HEL-S-128m VNN1 OSTC FASN CYP1A1 SERINC1 ACO2 REEP6 RETSAT ACADVL CYP4A22 HCCS NR1C1 PTPRG MCEE ACADL CPT2 CA4 IDH3B HEL-S-107 ACADM ACADS ADSL HSDL2 NBN HMGCS1 ELOVL5 CYP4A11 FACL4 HEL-S-25 S100A10 INMT HADHB UGDH HEL-S-278 ACOX1 EHHADH MGLL FH ECHS1 ADH1C HPGD ETFDH HSD17B4 EPHX1 LTC4S HSD17B11 HSD17B7 BPHL HSD17B10 PTS CRYZ HMGCL TP53INP2 D2HGDH SDHC PCBD1 ACSS1 MIF AADAT G0S2 GAD2 FABP1 ENO2 GSTZ1 FABP2 SUCLA2 APEX1 CRAT METAP1 HEL-S-133P HEL-S-32 H2AZ1 ME1 HEL-S-26 DLD GPD2 ALDH9A1 HEL-S-87p MDH2 SETD8 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDBHALLMARK%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB MAFF PLEK VEGFA MYC KYNU PTX3 OLR1 DUSP5 SERPINB2 F3 RNF19B MAP2K3 CEBPB IER5 TNLG5A SQSTM1 TAP1 CCL5 NINJ1 ATF3 JUN GADD45A MARCKS PLK2 LIF PTPRE BMP2 TNC G0S2 MXD1 TNF CCND1 BTG2 CDKN1A CD83 BTG1 CSF2 CSF1 CD80 ETS2 IFIT2 ZFP36 ZC3H12A CCRL2 NAMPT SLC16A6 IL12B MAP3K8 DENND5A PHLDA2 CCNL1 PHLDA1 JUNB MCL1 ICOSLG GEM IER2 IL15RA SPHK1 IL23A SIK1 PLPP3 TRIB1 IL6ST FOS BHLHB2 FUT4 BTG3 SOCS3 SNN IL1A MSC ABCA1 EGR1 SDC4 EGR2 TIPARP TNFRSF9 HBEGF NFKB1 PPP1R15A NFKB2 FOSL2 NFKBIA EFNA1 FOSL1 RCAN1 YRDC IL18 CXCL11 NR4A3 GADD45B BCL6 GPR183 B4GALT1 REL NFKBIE INHBA IL7R IRF1 NFE2L2 IL1B DRAM1 IL6 RIGI TNFAIP6 TNFAIP2 SLC2A3 CXCL3 BIRC3 LITAF ID2 SLC2A6 CXCL2 PANX1 IFIH1 PDE4B RELA KLF10 TGIF1 DUSP4 CXCL6 KDM6B KLF4 EDN1 DUSP2 RIPK2 IFNGR2 TRAF1 TNFAIP3 SERPINB8 TUBB2A CXCL1 SGK1 FJX1 AREG BIRC2 CD69 CYR61 B4GALT5 PTGER4 NFAT5 BCL2A1 CEBPD PTGS2 TANK SUI1 RELB NFIL3 DNAJB4 CCL4 CCL2 HES1 LDLR LAMB3 PLAUR CCL20 ATP2B1 KLF2 PNRC1 RHOB PER1 SPSB1 KLF6 TNIP2 CLCF1 KLF9 TRIP10 TMEPAI ACKR3 F2RL1 FOSB CD44 EHD1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDBHALLMARK%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING SLIT1 NRCAM NKX6-1 L1CAM CDK6 MYH9 VEGFA ETS2 HEY2 NF1 CDK5R1 PTCH1 PML OPHN1 TLE3 SCG2 THY1 ACHE CNTFR NRP1 NRP2 RTN1 LDB1 CRMP1 PLG CELSR1 AMOT VLDLR SHH HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDBHALLMARK%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS ERRFI1 GLDC CLU TMEM97 ANTXR2 ACTG1 CXCL16 TM7SF2 FADS2 FBXO6 HEL-S-4 GNAI1 STARD4 PCYT2 GPX8 SREBF2 ETHE1 PPARG EBP STX5A MVD ACSS2 HEL-S-7 MVK SEMA3B LPL HMGCR ATXN2 PMVK TP53INP1 MAL2 FDFT1 CTNNB1 NIBAN1 FDPS ABCA2 GSTM2 CHKA HEL-S-43 CYP51A1 FABP5 PLSCR1 SCD CD9 DHCR7 CPEB2 AVPR1A IDI1 ACAT2 GUSB TRIB3 ATF3 SC5D FASN NFIL3 TNFRSF12A HMGCS1 LDLR PLAUR PNRC1 ATF5 PDK3 HSD17B7 SQLE HALLMARK_INFLAMMATORY_RESPONSE%MSIGDBHALLMARK%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE SLC7A1 MYC OLR1 GP1BA F3 CD82 KIF1B NPFFR2 IRF7 CSF3 LCP2 IFITM1 CSF3R AQP9 ICAM4 AHR SLC4A4 IL18RAP RGS1 LAMP3 CLEC5A C3AR1 PROK2 LCK ROS1 TNLG5A SCN1B GNAI3 CMKLR1 IL1R1 SLC11A2 RAF1 CYBB IFNAR1 LY6E CALCRL CCL5 EBI3 C5AR1 FPR1 CD55 LPAR1 SLC1A2 MEFV HRH1 IRAK2 NLRP3 NDP ARHG MSR1 FZD5 EIF2AK2 NMI SELE BST2 MARCO SELL NMUR1 SELS RTP4 CD40 CXCL9 ATP2A2 ADM CX3CL1 GPR132 STAB1 BDKRB1 ITGB8 CCR7 FFAR2 IL10 PTGIR TNLG1B TACR3 TACR1 TNFRSF1B OSMR TAPBP TLR1 RNF144B HEL-S-75 MEP1A LTA CD48 TLR3 PTGER2 KCNA3 CXCR6 NOD2 SGMS2 LIF SRI ATP2C1 SLC7A2 CCL7 PTPRE P2RY2 PDPN HAS2 CCL17 KCNJ2 CCL24 GABBR1 CCL22 MXD1 SEMA4D SLC31A2 SLC31A1 PCDH7 IL10RA ADRM1 TNFSF10 BTG2 OSM CDKN1A OPRK1 ACVR2A P2RX7 CSF1 EREG P2RX4 AXL IL2RB TNLG8A VIP PSEN1 IL18R1 CCRL2 NAMPT IL12B CD14 ICOSLG IL15RA SPHK1 IL1A ABCA1 TNFRSF9 HBEGF NFKB1 NFKBIA RGS16 IL18 CXCL11 ACVR1B GPR183 INHBA IL7R IRF1 IL1B IL6 TNFAIP6 PDE4B RELA GNA15 CXCL6 CXCL8 EDN1 RIPK2 IFNGR2 ITGB3 CD69 ADORA2B PTGER4 TIMP1 MET IL15 CCL2 LDLR PLAUR CCL20 ATP2B1 EMP3 PIK3R5 KLF6 GPC3 HIF1A MMP14 LYN TPBG HALLMARK_TGF_BETA_SIGNALING%MSIGDBHALLMARK%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING ID2 SLC20A1 KLF10 TGIF1 SPTBN1 IFNGR2 CDKN1C BMPR2 HDAC1 FURIN ARID4B LTBP2 FNTA SKIL LEFTY2 JUNB ACVR1 NCOR2 UBE2D3 SMAD1 WWTR1 SMURF2 SMURF1 CTNNB1 NOG SMAD6 TGFBR1 HIPK2 TJP1 CDK9 FKBP1A SKI RAB31 ARHA MAP3K7 ID1 ID3 BMPR1A ENG PPP1R15A TGFB1 TMEPAI APC THBS1 BMP2 HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE HLA-DMA SLC25A28 PSMB2 STAT4 FCGR1A PFKP GBP4 PTPN1 CD74 STAT1 MX2 P2RY14 STAT3 MX1 LYSMD2 PSMB8 ZNFX1 PTPN6 PML UBE2L6 PLSCR1 IRF2 IFI30 IRF7 LCP2 C1S C1R CMKLR1 TRAFD1 TAP1 LY6E CCL5 FPR1 NOD1 TXNIP GZMA RAPGEF6 EIF2AK2 NMI BST2 RIPK1 RTP4 CD40 CXCL9 STAT2 SOCS1 ARL4A MYD88 MTHFD2 TAPBP SRI CCL7 IFITM3 IL10RA TNFSF10 RBCK1 CDKN1A BTG1 IL2RB IFIT2 NAMPT IL15RA SOCS3 VAMP8 CASP8 CASP3 CASP4 ISG20 SAMD9L NFKB1 IFITM2 SPPL2A IFI35 NFKBIA IFIT1 IFI44L IFIT3 PNP VCAM1 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 ZBP1 IFNAR2 IL6 RIGI RSAD2 TNFAIP6 SP110 TNFAIP2 HLA-B ARID5B HLA-A HLA-G NUP93 IFI27 PSME2 IFIH1 CMPK2 PDE4B TRIM14 IDO1 CSF2RB HELZ2 KLRK1 RNF213 ST8SIA4 RIPK2 ISOC1 SLAMF7 ST3GAL5 TNFAIP3 FAS HLA-DQA1 PNPT1 AUTS2 IFI44 CD69 ISG15 TDRD7 PARP14 TOR1B MHC2TA PARP12 PTGS2 MT2A SELP IL7 SSPN PIM1 XAF1 GPR18 HLA-DRB1 LGALS3BP IL15 CCL2 OGFR EIF4E3 SERPING1 SECTM1 LAP3 ADAR OASL CFH IL18BP ITGB7 BATF2 ApoL6 TMT1B LATS2 BANK1 HIF1A OAS2 PSMA2 IRF4 OAS3 PELI1 XCL1 IRF8 VAMP5 IRF9 RNF31 MARCHF1 MVP FGL2 USP18 PSMB10 HALLMARK_UV_RESPONSE_DN%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN CAP2 SLC7A1 MYC COL3A1 IRS1 PRDM2 NR3C1 PMP22 IGF1R PPARG ZMIZ1 AKT3 CDON IGFBP5 SFMBT1 PRKCE DYRK1A CDKN1B POLS PRKCA RUNX1 MAPK14 INPP4B MAP1B PTEN SCN8A AMPH MT1E F3 PTGFR INSIG1 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 RBPMS NR1D2 PHF3 SLC67A1 CELF2 SCHIP1 FHL2 PIK3CD PTPRM PTPN21 SYNE1 NIPBL DBP SIPA1L1 ABCC1 WDR37 MIOS ANXA2 ANXA4 VAV2 TGFBR2 ARHGEF9 RASA2 PLCB4 MMP16 FYN KCNMA1 KIT LPAR1 PIK3R3 GCNT1 MRPS31 TFPI ADD3 SPOP APBB2 ATP2B4 PEX14 FAM179B NFIB AGGF1 ADGRL2 MGLL CDC42BPA SRI ATP2C1 HAS2 ACVR2A RGS4 GJA1 SDC2 PLPP3 BHLHB2 TJP1 ID1 BMPR1A NFKB1 FBLN5 BDNF CITED2 COL1A1 VLDLR RXRA COL1A2 COL5A2 SNAI2 ERBB2 ITGB3 MGMT LAMC1 CYR61 ADORA2B MET LDLR ATP2B1 YTHDC1 TGFBR3 NRP1 NOTCH2 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING PTPN1 TNF STAT1 STAT3 CSF2 CSF1 IL18R1 MAP3K8 CD36 CD14 IL15RA IL6ST SOCS3 CD9 CSF3R IFNGR1 STAM2 CXCL11 TNFRSF1A ACVR1B IRF1 IL1R1 IL1B IL6 IFNAR1 CXCL3 EBI3 BAK1 IL2RG CSF2RB IFNGR2 ITGB3 ACVRL1 FAS CXCL13 CXCL1 LEPR HAX1 ITGA4 IL1R2 DNTT TYK2 CXCL9 IL17RB IL17RA IL3RA STAT2 LTB PTPN11 TNFRSF21 IL9R IL7 CBL PIM1 CSF2RA SOCS1 PDGFC TNFRSF12A IL12RB1 A2M HMOX1 CCR1 IL10RB PLA2G2A INHBE GRB2 TNFRSF1B IL2RA MYD88 OSMR LTBR CRLF2 PF4 PIK3R5 JUN TGFB1 CD44 CNTFR IRF9 IL13RA1 CCL7 HALLMARK_DNA_REPAIR%MSIGDBHALLMARK%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR SAC3D1 POM121 AK1 XPC RFC4 LIG1 ARL6IP1 MPG GTF2B CLP1 MPC2 HEL74 GTF2F1 RBX1 BCAM HPRT1 GC20 SRSF6 VPS28 CCNO TSG101 NPR2 CSTF3 COX17 SUPT4H1 AAAS BOLA2B SDCBP DGUOK ZNF707 SURF1 ADA POLR3GL ALYREF UPF3B ADRM1 SUPT5H ZWINT POLA2 POLA1 AGO4 STX3A RNP24 FEN1 ELL CETN2 SNAPC5 SEC61A1 MRPL40 ZNRD1 GUK1 SNAPC4 REV3L AK3 DKFZp781O1323 DGCR8 ELOA NELFB POLL NELFCD NCBP2 NME3 VPS37D RFC3 NME4 RFC2 EDF1 VPS37B APRT NT5C3A DDB2 DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA CANT1 GTF3C5 RNMT PRIM1 PCNA USP11 GPX4 DCTN4 POLD3 GMPR2 TAF9 PNP TYMS ADCY6 POLD4 POLR2A POLR2C POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J RAE1 DUT POLR2K BRF2 TAF12 PDE6G TAF13 TAF10 GTF2H3 CMPK2 PDE4B GTF2H5 TARBP2 SSRP1 RAD52 RAD51 POLE4 POLR3C NUDT21 IMPDH2 ERCC1 ERCC2 BCAP31 RPA3 TAF6 DFNA5 ERCC5 CDA HALLMARK_ADIPOGENESIS%MSIGDBHALLMARK%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS EPHX2 CHCHD10 RMDN3 COQ9 DNAJC15 COQ5 CS COQ3 UCK1 REEP5 UQCRQ NMT1 NABP1 PEMT SLC25A1 COX7B ORM1 RNF11 SOWAHC HSPB8 ETFB PPARG GPHN AIFM1 ALDH2 CD36 NKIRAS1 DBT LPL DLAT YWHAG ADIG COX8A JAGN1 CHUK ELMOD3 ELOVL6 MRAP PPM1B NDUFS3 ITGA7 CD302 PPP1R15B NDUFB7 SLC66A3 LAMA4 DHCR7 PTGER3 UQCR11 RETN UQCR10 AGPAT3 SAMM50 DDT GPAT4 UCP2 UBQLN1 DNAJB9 SNCG DRAM2 MAP4K3 PTCD3 ANGPT1 SUCLG1 CAVIN1 NDUFA5 CAVIN2 RIOK3 SQOR VEGFB CYP4B1 ADIPOR2 IMMT DHRS7 PFKL FABP4 GPAM DECR1 CCNG2 LEP HEL-S-62p LPCAT3 NDUFAB1 CIDEA ATP5PO ESYT1 PEX14 ACO2 REEP6 RETSAT ACADL CPT2 ACADM ACADS ARL4A ACOX1 MGLL ECHS1 GADD45A LTC4S AK2 SDHC CRAT MYLK COL4A1 ABCA1 GPX4 GPX3 IFNGR1 ADCY6 BCL6 TOB1 CDKN2C STOM ME1 SCARB1 HEL-S-26 MTCH2 SLC27A1 ARAF GHITM COX6A1 LIPE ENPP2 PIM3 PHYH DGAT1 SLC25A10 MCCC1 ANGPTL4 TANK OMD ATP1B3 SSPN CMBL SDHB DLD SLC5A6 ACLY GPD2 POR ADFP RAB34 CMPK1 HEL-S-87p UQCRC1 SPARCL1 PREB RTN3 CD151 MTARC2 MGST3 ABCB8 BAZ2A MRPL15 PRDX3 SULT1A1 GRPEL1 MDH2 DHRS7B UBC G3BP2 APOE CYC1 RREB1 HEL-S-44 SLC19A1 ESRRA FZD4 HEL107 HALLMARK_ALLOGRAFT_REJECTION%MSIGDBHALLMARK%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION HLA-DMA STAT4 CD74 STAT1 CTSS PTPN6 HEL-S-71 MAP3K7 IRF7 LCP2 CCND3 NCK1 CCND2 PRKCB IL18RAP TRAF2 LCK WAS F2R CD1D TAP1 CCL5 GCNT1 IL2RG GZMA NLRP3 SPI1 EGFR GPR65 NCF4 CD40LG UBE2D1 RPL9 IL27RA RPS19 CXCL13 SIT1 IL12A HLA-DOA HLA-DOB RPL39 TPD52 CD40 CD96 CXCL9 RPS9 KRT1 TAP2 LTB CARTPT HLA-E IL4 STAB1 CD8A FLNA AARS1 SOCS1 IGSF6 TNFSF6 CFP IL12RB1 CD79A IL10 ELANE CCR1 SOCS5 FYB1 CRTAM LY86 IL2RA IL2 RPL3L TAPBP PTPRC TLR1 PF4 IL9 HLA-DRA TGFB1 DEGS1 KLRD1 ITK TLR3 DYRK3 CD3G CD3E CD3D IKBKB LIF MRPL3 INHBB CCR5 CCR2 MBL2 CCL7 RARS1 EIF5A MAP4K1 SRGN IL11 IL13 CD8B1 IL16 RPS3A CCL22 MMP9 PRF1 NCR1 ZAP70 IFNG TNF ELF4 CD47 BCAT1 CCL13 CCL11 ACVR2A MTIF2 CSF1 EREG HDAC9 CD80 HLA-DMB CXCR3 IL2RB CSK CCL19 GBP2 BCL10 NPM1 NOS2 TRAT1 IL12B GALNT1 c-fgr CD7 EIF3J ABCE1 HEL-S-66 FCGR2B EIF3D ICOSLG EIF3A BRCA1 HCLS1 THY1 IFNGR1 IL18 F2 B2M INHBA IL1B IFNAR2 IL6 HLA-A HLA-G CDKN2A ST8SIA4 RIPK2 IFNGR2 FAS HLA-DQA1 CD2 IL7 TIMP1 CCL4 IL15 CCL2 C2 HIF1A IRF4 ACHE LYN IRF8 PSMB10 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDBHALLMARK%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE SLC25A28 IFITM3 GBP4 CD74 CD47 MX1 CSF1 PSMB8 IFIT2 GBP2 CCRL2 TMEM140 NUB1 TRIM5 HLA-C TENT5A ELF1 OAS1 NCOA7 UBE2L6 CNP SAMD9 UBA7 PLSCR1 GMPR CASP8 MVB12A MOV10 IRF2 IFI30 IRF7 ISG20 IFITM1 SAMD9L IFITM2 IFI35 IFI44L IFIT3 C1S LAMP3 DHX58 CXCL11 EPSTI1 TRIM25 CMTR1 B2M TRIM21 HERC6 IRF1 RSAD2 TRAFD1 SP110 TAP1 LY6E PROCR IFI27 IFIH1 PSME2 CMPK2 TXNIP TRIM14 HELZ2 RIPK2 EIF2AK2 NMI BST2 PNPT1 SELL IFI44 RTP4 ISG15 TDRD7 PARP14 STAT2 PARP12 IL7 LGALS3BP IL15 OGFR ADAR LAP3 OASL BATF2 IRF9 RNF31 USP18 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY MPPED2 TFF1 FOXC1 SLC24A3 ATL1 TMPRSS3 ASB13 SLC7A5 ADCY1 PAPSS2 THSD4 TMEM164 ABLIM1 MUC1 PDLIM3 OLFML3 LRIG1 MYC RBBP8 SH3BP5 EEIG1 HSPB8 MICB IGF1R CA12 SVIL KDM4B NHERF1 ZNF185 SEMA3B AMFR KRT13 SNX24 NCOR2 DHRS2 KLK10 DHRS3 TTC39A FDFT1 KRT19 MLPH MYBBP1A CHPT1 RAB17 GLA FRK TJP3 ABAT DHCR7 FHL2 SLC22A5 ADD3 FASN IL17RB FLNB ELOVL5 SFN SLC19A2 FARP1 INHBB SLC7A2 P2RY2 CCND1 FKBP4 GJA1 IGFBP4 PMAIP1 STC2 ELF1 IL6ST FOS BHLHB2 RAB31 FCMR WWC1 TIPARP HR CANT1 NADSYN1 AQP3 CELSR2 RAPGEFL1 SOX3 DEPTOR RPS6KA2 MYB TBC1D30 CCN5 SLC39A6 SYBU B4GALT1 MREG CISH TOB1 NPY1R KAZN KCNK15 OVOL2 RARA SULT2B1 OLFM1 CXCL12 ADCY9 CLDN7 SCNN1A PPIF PGR NBL1 SLC27A2 PTGES KLF10 FKBP5 SLC26A2 HEL-S-10 KLF4 MINDY1 TPD52L1 ARL3 ABHD2 SLC1A1 ENDOD1 SCARB1 ISG20L2 RHOBTB3 SLC1A4 UGCG MED24 KRT18 SYNGR1 AREG ELF3 CALCR INPP5F ALDH3B1 TFF3 BAG1 TFAP2C XBP1 OPN3 SLC37A1 WFS1 SIAH2 ABCA3 GREB1 MED13L REEP1 HES1 KCNK5b BCL2 UNC119 RETREG1 RET LAD1 CLIC3 NXT1 PRSS23 AFF1 CALB2 CYP26B1 ANXA9 MYBL1 MSMB TGIF2 TIAM1 DYNLT3 CD44 ELOVL2 ITPK1 TPBG MYOF PLAAT3 GAB2 NAV2 CELSR1 CBFA2T3 RHOD ESRP2 HALLMARK_HYPOXIA%MSIGDBHALLMARK%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAFF GPC1 PFKP ERRFI1 RBPJ SLC25A1 VEGFA NR3C1 CA12 CDKN1B PRKCA MT1E F3 ENO3 TES RORA KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN PPP1R3C PKP1 LXN HACL2 FOXO3A PRDX5 LARGE LYZG PCK1 B4GALNT2 PPARGC1A KLHL24 SRPX CAVIN1 NCAN HEXA HEL-S-134P ANXA2 PYGM BRS3 AKAP12 CSRP2 STBD1 ATP7A PFKL EDN2 GAA MYH9 CXCR4 DDIT3 AMPD3 CCNG2 DDIT4 FBP1 CHST3 TMEM45A S100A4 KDM3A DGIC EGFR HAS1 NOCT GCNT2 ATF3 VHL XPNPEP1 MAP3K1 PKLR CAVIN3 GCK HS3ST1 KLF7 NAGK INHA TPD52 ADM HMOX1 ERO1A HEL-S-278 JUN HEL-S-75 ZNF292 ENO1 HEL-S-89n DPYSL4 PDK3 MIF SAP30 ENO2 RRAGD CTGF KDELR3 BNIP3L CDKN1A BTG1 ZFP36 CDKN1C SDC2 SDC3 STC1 AK4 LOX STC2 ANKZF1 FOS BHLHB2 HEL-S-133P SDC4 B3GALT6 TIPARP EXT1 ISG20 PPP1R15A EFNA3 FOSL2 P4HA1 EFNA1 P4HA2 CCN5 CITED2 IL6 VLDLR HK2 SULT2B1 SLC2A3 GYS1 CASP6 TGFBI PGM2 SLC37A4 PGAM2 HEL-S-68p SCARB1 TNFAIP3 HEL-S-19 CYR61 ADORA2B MT2A ANGPTL4 ALDOB PIM1 SIAH2 NFIL3 ADFP BCL2 PLAUR HEL-S-87p DCN GLRX PNRC1 KLF6 MXI1 GPC3 GPC4 ACKR3 TPBG CP HEL-S-49 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDBHALLMARK%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE SLC7A5 NABP1 VEGFA HEL-S-125m IGFBP1 CEBPB DNAJB9 TSPYL2 DDIT4 HEL-S-99n ATF3 EIF4E EIF4A2 EIF4A1 POP4 EIF4A3 RRP9 EDC4 RPS14 TATDN2 KHSRP BANF1 CHAC1 IMP3 SLC30A5 DDX10 PDIA5 ERN1 NHP2 ATP6V0D1 ERO1A MTHFD2 TARS1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 SEC31A FUS HEL-S-89n EDEM1 LSM1 ASNS EEF2 LSM4 CNOT4 NOLC1 CNOT6 CNOT2 SRPRA SRPRB HYOU1 ALDH18A1 IARS DCP1A EIF4G1 FKBP14 SERP1 WIPI1 YWHAZ SKIC3 EIF2S1 DCP2 EXOC2 KDELR3 SKIV2L2 DCTN1 GOSR2 CEBPG CXXC1 SDAD1 EXOSC5 EXOSC10 EXOSC4 H2AX SEC11A EXOSC1 NPM1 PAIP1 NFYA NFYB SPCS3 CKS1B SPCS1 XPOT DNAJA4 PSAT1 STC2 IFIT1 DNAJC3 NOP56 TUBB2A SLC1A4 XBP1 WFS1 CCL2 DKC1 HEL-S-61 PREB HALLMARK_APICAL_SURFACE%MSIGDBHALLMARK%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE ADIPOR2 GSTM3 PCSK9 IL2RG IL2RB AKAP7 LYPD3 CX3CL1 SLC2A4 PKHD1 SCUBE1 FLOT2 APP ATP6V0A4 EPHB4 TMEM8B NTNG1 SLC34A3 ATP8B1 BRCA1 CD160 PLAUR NCOA6 ADAM10 GATA3 SULF2 RTN4RL1 CROCC MAL HEL-S-102 GHRL THY1 EFNA5 RHCG MDGA1 GAS1 SHROOM2 LYN B4GALT1 SRPX HALLMARK_HEME_METABOLISM%MSIGDBHALLMARK%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM ERMAP RBM5 HTATIP2 VEZF1 SPTB TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 MOSPD1 CLCN3 ADD2 AGPAT4 NR3C1 RHD E2F2 TRAK2 FY MARCHF8 CIRSR DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 CTNS XPO7 PDZK1IP1 KLF3 EPOR KLF1 CPOX SLC25A38 HEL-76 SLC25A37 TSPO2 XK HEL-S-2a RHAG UROD YPEL5 LPIN2 TNRC6B MAP2K3 CCND3 ICAM4 ARHGEF12 UCP2 FOXO3A USP15 HEL-S-134P RIOK3 SLC11A2 HEL-S-62p UROS TFRC HBZ BCAM ASNS HEL-S-304 SDCBP BTG2 BNIP3L SLC7A11 ABCB6 H1-0 AQP3 GCLC ISCA1 NARF GDE1 SLC4A1 P4HA2 BACH1 CCDC28A PPP2R5B NUDT4 PSMD9 tal-1 RNF19A BTRC FBXO7 FBXO9 TNS1 CAST LMO2 ACSL6 SLC30A1 SLC6A8 GAPVD1 MYL4 MINPP1 RNF123 KEL hEMMPRIN DAAM1 ADD1 HMBS GLND1 RHCE HEL-S-10 OPTN ABCG2 OSBP2 SIDT2 SLC22A4 ENDOD1 EPB42 FECH GYPC IGSF3 GYPB GYPE DCUN1D1 HTRA2 HEL-S-11 ADIPOR1 SLC30A10 GATA1 RAP1GAP LAMP2 CDC27 SPTA1 TSPAN5 CDR2 FN3K NFE2 H4C9 EIF2AK1 SLC10A3 FBXO34 TYR RCL1 MFHAS1 ARL2BP SLC6A9 SYNJ1 MGST3 MKRN1 MXI1 RANBP10 TMCC2 LRP10 GCLM EZH1 NFE2L1 TMEM9B PICALM ALAS2 HBB HBD FTCD HEBP1 NNT ACP5 CLIC2 PC HALLMARK_PROTEIN_SECRETION%MSIGDBHALLMARK%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION GOSR2 RNP24 ANP32E COPB2 CLCN3 CTSC ARF1 CLTC IGF2R PPT1 RPS6KA3 GLA ADAM10 ABCA1 KIF1B AP2M1 SNAP23 CLTA RAB22A GOLGA4 SCRN1 AP1G1 DST AP3S1 SH3GL2 RAB2A STX7 AP3B1 OCRL ARFGAP3 SCAMP3 TOM1L1 VAMP7 RER1 TMX1 ERGIC3 SEC22B VAMP4 ATP6V1B1 ATP7A VAMP3 NAPA CD63 STX12 TMED10 SGMS1 STX16 COPB1 VPS4B USO1 EGFR ATP1A1 NAPG CLN5 LMAN1 SNX2 TSPAN8 AP2S1 MAPK1 YKT6 ARFGEF2 KRT18 MON2 CAV2 TPD52 BNIP3 GBF1 M6PR ARCN1 RAB14 DOP1A GNAS LAMP2 SSPN YIPF6 RAB9A RAB5A COPE BET1 ARFGEF1 ZW10 SEC31A TSG101 HEL-S-44 COG2 HALLMARK_APICAL_JUNCTION%MSIGDBHALLMARK%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION SLIT2 ACTG1 MYH10 GNAI1 IRS1 AKT3 NF1 MVD MAPK14 PTEN WASL pk INSIG1 ICAM4 SHROOM2 RHOF SRC PFN1 VAV2 MYH9 PIK3R3 EGFR NF2 PLCG1 CX3CL1 CTNND1 ICAM2 INPPL1 FYB1 LNIR HEL-S-79 DMP1 ICAM5 ACTG2 PTPRC CDH8 SHC1 TIAL1 CDH4 SIRPA NRTN HEL70 SCAP2 GTF2F1 JAM3 ACTN1 CLDN6 CLDN5 CLDN4 TAOK2 ADAM15 CERCAM ALOX15B COL16A1 DSC1 DSC3 COL17A1 GRB7 WNK4 MYL12B CNN2 RRAS TSPAN4 SYMPK MMP9 RSU1 CD99 CLDN9 VASP CADM3 CDSN JUP CRAT CADM2 PARVA CDH6 CDK8 ITGB4 ARPC2 CD209 CNTN1 COL9A1 PALS1 ADRA1B PKD1 SGCE TRO SDC3 ADAMTS5 PS1TP5BP1 MDK DHX16 HRAS SPEG MADCAM1 IKBKG AMH CD34 CAP1 MAP4K2 SYK VWF HEL-S-20 TMEM8B KRT31 CLDN11 TJP1 TUBG1 ACTA1 CLDN15 CLDN14 CLDN19 EXOC4 PECAM1 EVL CDH15 NLGN3 TNFRSF11B NLGN2 THY1 AMIGO1 AMIGO2 NRXN2 PARD6G THBS3 LIMA1 VCAM1 ADAM23 NRAP CTNNA1 MPZL1 B4GALT1 MPZL2 NEGR1 NHERF4 SORBS3 MAPK13 MAPK11 BMP1 PPP2R2C ZYX NECTIN3 NECTIN2 CLDN7 CRB3 NECTIN1 TGFBI FBN1 ITGB1 BAIAP2 TRAF1 LAMC2 HEL114 ACTN2 ITGA2 ADAM9 MMP2 LAMB3 TSC1 ACTN4 CALB2 VCAN CDH11 STX4A LAMA3 HALLMARK_PANCREAS_BETA_CELLS%MSIGDBHALLMARK%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS LMO2 NKX6-1 PCSK2 PCSK1 STXBP1 NR1i1 SLC2A2 SRP14 FOXO1 INS NEUROD1 SCGN NKX2-2 ABCC8 PAX4 SEC11A PKLR PDX1 GCG PAX6 GCK ELP4 AKT3 HNF1A SYT13 ISL1 SPCS1 SRP9 G6PC2 MAFB SST DCX IAPP INSM1 FOXA2 NEUROG3 DPP4 SRPRB HALLMARK_XENOBIOTIC_METABOLISM%MSIGDBHALLMARK%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM CYP2J2 GSTM4 GCKR CYP4F2 IGF1 G6PC1 CYP26A1 TMEM97 LR8 CYP2S1 PAPSS2 CYP1A2 HRG NMT1 GUGU ABCD2 NR1C2 PEMT ALAS1 LEAP2 CROT AOX1 ACP2 MAN1A1 KYNU HGFAC ABCC3 ARG2 ABCC2 ALDH2 CD36 HEL-S-21 ARG1 DHPS SSR3 PTGR1 NPC1 SMOX ANGPTL3 TMBIM6 ACOX3 CYFIP2 CRP ITIH4 DDC KARS1 HEL-S-51e CYP17A1 HEL-76 PGRMC1 SERTAD1 ATOH8 TDO2 HSD17B2 XDH MARCHF6 IGFBP1 CCL25 LPIN2 MPP2 NQO1 PTGES3 GABARAPL1 F11 AQP9 DDT AKR1C2 HEL-S-182mP DHRS1 PINK1 GSTA3 CDO1 ALDH3A1 TNFRSF1A PLG IL1R1 MAOA ADH7 DHRS7 F10 FBP1 NINJ1 VNN1 GCNT2 EPHA2 CYP1A1 ACO2 RETSAT SLC35D1 ATP2A2 HMOX1 ELOVL5 UGDH ACOX1 PMM1 ADH1C ETFDH EPHX1 HPRT1 GAD1 BPHL MBL2 PTS TPST1 FABP1 JUP BCAT1 ETS2 IGFBP4 ARPP19 DCXR GCLC HEL-75 ID2 CASP6 PTGES HEL-S-10 HEL-S-26 FAS CDA NR2A1 MT2A RAP1GAP HEL-S-277 SLC46A3 PROS1 SLC35B1 POR CNDP2 PDK4 ALDH9A1 LONP1 HEL-S-64p TYR MCCC2 HES6 ENTPD5 SLC6A12 CYP27A1 RBP4 MTHFD1 CYP2E1 CES1 ENPEP SAR1B SLC22A1 GSTT2 ABHD6 IRF8 NDRG2 CYP2C18 APOE ADH5 HSD11B1 VTN pcap TTPA ASL PSMB10 PC HALLMARK_ANGIOGENESIS%MSIGDBHALLMARK%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS VAV2 SPP1 COL5A2 MSX1 S100A4 CXCL6 VEGFA COL3A1 POSTN OLR1 STC1 LPL PDGFA ITGAV TNFRSF21 TIMP1 APP JAG2 PF4 CCND2 VCAN LRPAP1 NRP1 THBD APOH PGLYRP1 KCNJ8 VTN PRG2 FSTL1 SLCO2A1 FGFR1 HALLMARK_MYOGENESIS%MSIGDBHALLMARK%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS AGRN IGF1 HDAC5 PSEN2 ABLIM1 COL3A1 HSPB8 DMD SVIL CD36 RB1 APP FDPS ITGA7 ENO3 SCD SPTAN1 NQO1 PPP1R3C ACSL1 SCHIP1 TSC2 LARGE COX6A2 PYGM SLN GJA5 MYOZ1 EPHB3 KCNH1 CHRNB1 GABARAPL2 GAA MYH9 MEF2C TPM3 DAPK2 FST MYL11 IFRD1 MYL7 MYL1 MYL2 MYL3 PVALB CFD CHRNA1 NOTCH1 FLII AEBP1 FOXO4 COX7A1 AK1 CNN3 EIF4A2 SYNGR2 IGFBP7 APOD PRNP CAV3 DMPK OCEL1 GNAO1 PKIA RIT1 FXYD1 HRC MYF6 RYR1 MYOM1 FHL1 ATP2A1 LDB3 MYL6B MYOM2 HSPB2-C11orf52 CSRP3 SGCA TGFB1 MB BDKRB2 ANKRD2 HEL-S-101 MYBPC3 MYOG TEAD4 PTGIS TNNC1 DENND2B TNNC2 HEL-S-29 SPARC SIRT2 MYH1 MYH2 PTP4A3 TNNT1 LPIN1 TNNT3 CASQ2 PLXNB2 MYH8 PICK1 HEL-S-273 MAPRE3 CASQ1 FGF2 CLU KIFC3 MYH4 tmp_locus_29 MYH7 CRAT MYLK CDKN1A CTF1 CKMT2 ITGB4 EFS CHRNG DKFZp686P11128 TNNI2 NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SH2B1 SPDEF MYBPH PDE4DIP MAPK12 MYO1C SPEG KLF5 FKBP1B TCAP CACNA1H PFKM WWTR1 SPHK1 STC2 COL4A2 ADAM12 BHLHB2 ACTA1 HBEGF GPX3 GADD45B SORBS3 COL1A1 TNNI1 ADCY9 SLC6A8 MYL4 ITGB1 ERBB3 TPD52L1 ITGB5 PGAM2 SGCD BAG1 SSPN ACTN2 SGCG REEP1 ACHE BIN1 AGL NAV2 PC HALLMARK_MTORC1_SIGNALING%MSIGDBHALLMARK%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING PSMC4 CTH TMEM97 SLC7A5 TM7SF2 NMT1 FADS2 PLK1 STARD4 NHERF1 IGFBP5 GSK3B CTSC HMGCR UBE2D3 SLA NIBAN1 ELOVL6 HEL-S-125m INSIG1 HEL-S-51e GLA TBK1 CYP51A1 TES SCD CD9 HEL-S-162eP DHCR7 IFI30 MAP2K3 ACTR3 ACTR2 FDXR IDI1 SQSTM1 ADIPOR2 IMMT PFKL RDH11 CXCR4 DDIT3 PIK3R3 DDIT4 DAPP1 ADD3 IFRD1 TRIB3 DHCR24 HEL-S-99n NUPR1 USO1 ACACA PSMG1 YKT6 TFRC AURKA M6PR ATP2A2 RRP9 RIT1 CFP HMGCS1 ELOVL5 DDX39A NFKBIB ERO1A MTHFD2 SSR1 ENO1 NUP205 HEL-S-89n SCAP2 EDEM1 ASNS HPRT1 PLOD2 SERP1 BTG2 BCAT1 CDKN1A SLC7A11 SEC11A NAMPT EBP STC1 AK4 PSAT1 PITPNB PSPH FADS1 ACSL3 SYTL2 MTHFD2L AF1Q FKBP2 BHLHB2 PSMD12 TUBG1 PSMD13 RPN1 CORO1A ATP6V1D HEL-S-94n HEL-S-133P HEL-S-66p SDF2L1 HSPA4 PNO1 MCM2 PPP1R15A EIF2S2 HEL-S-283 GCLC CCT6A P4HA1 UNG DHFR COPS5 EPRS1 PNP ATP5G1 PHGDH SORD CACYBP UCHL5 PSMA4 HEL-75 CANX EEF1E1 RAB1A VLDLR NUFIP1 HK2 TOMM40 ETF1 HSPD1 SLC2A3 HEL-S-69p GGA2 ABCF2 RRM2 CYB5B NFYC PDAP1 UFM1 ME1 PSMC6 RPA1 POLR3G HMBS SLC37A4 SC5D CCNG1 HEL-S-68p HEL-S-26 SLC1A4 XBP1 NFIL3 ACLY LDLR HEL-S-87p GLRX TUBA4A EGLN3 SQLE FGL2 HEL-S-49 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDBHALLMARK%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE TFF1 FOXC1 SLC24A3 SERPINA1 TMPRSS3 SLC7A5 PAPSS2 PDLIM3 RBBP8 PTPN6 EEIG1 HSPB8 MICB ETFB CA12 NHERF1 GINS2 SEMA3B AMFR KRT13 NCOR2 DHRS2 TOP2A KLK10 FDFT1 KRT19 CHPT1 GLA HEL-76 FRK TJP3 FABP5 CD9 DHCR7 PTGER3 LARGE ALDH3A2 SLC22A5 ADD3 ATP2B4 HSPA4L IL17RB CDC20 FLNB ELOVL5 SFN FARP1 UGDH ST14 RNASEH2A HPRT1 TNNC1 HEL-S-29 PLK4 CCND1 KIF20A FKBP4 ZFP36 IGFBP4 MDK DCXR IL6ST FOS BTG3 RAB31 HR ISG20 CELSR2 RAPGEFL1 SOX3 RPS6KA2 MYB CCN5 SORD TFPI2 CISH TOB1 NPY1R MAPK13 OVOL2 SULT2B1 PERP OLFM1 CXCL12 SCNN1A ID2 PPIF PGR NBL1 SLC27A2 NAB2 PTGES CXCL14 FKBP5 TRIM29 SLC26A2 UNC13B HEL-S-10 KLF4 METTL3 TPD52L1 CACNA2D2 ARL3 DUSP2 PRLR ABHD2 PCP4 PKP3 SCARB1 LLGL2 IGSF1 LAMC2 SLC1A4 PLAC1 SGK1 HOMER2 XRCC3 AREG CALCR CYP4F11 TH ALDH3B1 GJB3 TFF3 BAG1 DLG5 TFAP2C GPER XBP1 NMU OPN3 PLXNB1 FGFR3 WFS1 SERPINA3 SIAH2 MOCS2 ABCA3 ST6GALNAC2 SNX10 SLC2A8 IMPA2 KCNK5b TPSAB1 BCL2 JAK1 CHST8 S100A9 EMP2 RET LSR DNAJC1 CLIC3 GAL NXT1 JDP1 PRSS23 SLC29A1 AFF1 ASCL1 AGR2 CYP26B1 TM4SF13 STIL ANXA9 ASS1 KLK11 BATF TIAM1 CDC6 DYNLT3 CD44 ITPK1 TPBG MYOF PLAAT3 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDBHALLMARK%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION COX6B1 OXA1L COX7A2L RHOT2 COXFA4 UQCRC2 UQCRB ABCB7 CS ATP5MC2 ATP5MC3 ATP5J COX7A2 UQCRQ ATP5H UQCRH ACAT1 ALAS1 MRPL11 TIMM50 COX7B CYB5R3 RHOT1 COX11 NDUFV2 ATP5MG ETFB ATP5MF ATP6V1C1 AIFM1 COX10 ATP5ME ATP6V1F ACADSB DLAT GLUD1 OGDH CYCS COX8A MRPS15 SLC25A3 COX4I1 MRPS11 MRPS12 ETFA TCIRG1 NDUFS3 MRPL34 COX7C MRPL35 OPA1 NDUFB7 TIMM17A UQCRFS1 TOMM70 ATP6V0B UQCR11 MRPS22 NDUFC2 UQCR10 CPT1A NDUFC1 BDH2 NDUFS8 NDUFS6 VDAC3 NDUFS4 SDHD NDUFS1 SDHA SLC25A12 SLC25A5 ATP6V0C FXN SLC25A11 SLC25A4 SUCLG1 SLC25A6 NDUFB8 NDUFA5 NDUFB6 NDUFB5 NDUFB4 TIMM9 PPM2C NDUFB3 NDUFB2 IMMT TIMM13 NDUFB1 MRPS30 TIMM10 DECR1 HEL-S-123m PDHA1 COX5A MFN2 SLC25A20 NDUFAB1 MST065 ATP5PO NDUFA9 TIMM8B NDUFA7 ISCU NQO2 NDUFA6 ATP5PB MTX2 ACO2 ZNF183 NDUFA3 RETSAT ACADVL NDUFA2 ATP5F1D HCCS ATP5F1E IDH3B LDHB ACADM HADHB FH LRPPRC ECHS1 ETFDH HSD17B10 COX17 SDHC SURF1 SUCLA2 GOT2 ATP6V1D HEL-S-133P ISCA1 GPX4 ATP5G1 HEL-S-32 POLR2F BAX HEL-S-26 COX6A1 HTRA2 PHYH SDHB DLD POR FDX1 PDK4 UQCRC1 MGST3 MRPL15 PRDX3 MTRR GRPEL1 MDH2 PHB2 HEL-S-271 MTRF1 MPC1 PMPCA CYC1 ATP6V1E1 PDHX ATP6V1G1 NNT ATP6V0E1 ATP1B1 HALLMARK_ANDROGEN_RESPONSE%MSIGDBHALLMARK%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE CDK6 PA2G4 CCND1 ADRM1 ZMIZ1 SPDEF ANKH SPCS3 HMGCR INPP4B H1-0 FADS1 KRT19 ACSL3 INSIG1 RPS6KA3 SCD CCND3 DNAJB9 PTPN21 SORD SMS B4GALT1 B2M HEL-75 GNAI3 IDI1 AKAP12 ARID5B FKBP5 SLC26A2 DHCR24 ABHD2 LMAN1 SGK1 HOMER2 SRP19 STEAP4 TPD52 NGLY1 DBI CDC14B HERC3 ITGAV PGM3 SMP1 NKX3-1 PIAS1 ALDH1A3 MAF HMGCS1 MAK ELOVL5 SELENOP PLPP1 STK39 TMPRSS2 KLK3 TARP MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I XRCC5 HPGD APPBP2 TMEPAI VAPA ACTN1 CENPN GPD1L MERTK HALLMARK_KRAS_SIGNALING_UP%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP SPP1 LR8 CTSS PRRX1 PSMB8 CROT ARG1 SEMA3B ADAM17 FCER1G HEL-76 RETN CCND2 SCG5 SCG3 NGF C3AR1 SCN1B CMKLR1 PCSK1N AKAP12 CXCR4 TFPI SNAP91 CIDEA IL2RG DOCK2 MAP3K1 APOD CBL CSF2RA ALDH1A3 TNFRSF1B ERO1A FUCA1 PLVAP SPON1 LIF HCA112 SOX9 F13A1 PRDM1 IKZF1 FGF9 BMP2 MAP4K1 FBXO4 EPHB2 ST6GAL1 ATG10 ANXA10 BTC G0S2 CLEC4A MMP9 SLPI PLAT MALL ADAM8 TRIB2 IL10RA ZNF277 TPH1 JUP ABCB1 LY96 CSF2 TSPAN7 EREG EPB41L3 HDAC9 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 IGF2 AMMECR1 PPBP NR0B2 ANKH GNG11 GADD45G CCSER2 STRN AVL9 PIGR SNAP25 MTMR10 FLT4 TMEM100 RBM4 CD37 VWA5A TRIB1 TEM5 CDADC1 PEG3 MMD PDCD1LG2 ETV4 MMP10 ETV5 WDR33 PECAM1 LAT2 MMP11 ZNF639 HBEGF ENG ALDH1A2 PPP1R15A TLR8 LCP1 SDCCAG8 USP12 RGS16 USH1C HOXD11 YRDC IL1RL2 RELN EMP1 GPNMB CBR4 MPZL2 IL33 PTCD2 GALNT3 INHBA IL7R H2BC3 IL1B GABRA3 NR1H4 LAPTM5 NAP1L2 WNT7A BIRC3 TMEM158 CFHR2 ID2 SPRY2 SATB1 ADGRL4 KLF4 PCP4 TRAF1 TNFAIP3 GYPC MAFB PTGS2 ANGPTL4 SERPINA3 ITGA2 PLAUR CCL20 SPARCL1 CFH GLRX RBP4 TM4SF13 F2RL1 IRF8 NRP1 HSD11B1 HALLMARK_BILE_ACID_METABOLISM%MSIGDBHALLMARK%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM EPHX2 ALDH8A1 FADS2 ABCD2 CROT NPC1 ABCA2 KLF1 ATXN1 HEL-S-53e MLYCD SLC67A1 AQP9 ACSL1 HEL-S-182mP FDXR ACSL5 PRDX5 LCK IDI1 DHCR24 RETSAT HSD17B4 HSD17B11 NR0B2 PFKM FADS1 ABCA1 RXRA NR1H4 SULT2B1 PECR SLC23A2 SLC35B2 SLC27A2 SLC23A1 CYP46A1 HEL111 NR3C2 PEX26 OPTN LONP2 NUDT12 ABCG8 ISOC1 DIO1 PIPOX HEL-S-26 CH25H GNPAT SOAT2 RBP1 PEX11G LIPE ABCG4 SLC27A5 HAO1 PHYH ABCA5 ABCA6 ABCA4 ABCA9 ABCA8 BMP6 ABCA3 SULT1B1 AMACR PXMP2 SLCO1A2 ABCD3 TFCP2L1 ALDH9A1 LOC51064 ABCD1 CYP7B1 PEX7 PEX6 EFHC1 CYP27A1 AGXT SLC29A1 PAOX AKR1D1 HSD17B6 CYP7A1 GCLM GC RXRG PEX16 HSD3B7 PEX19 PNPLA8 HSD3B1 NR1i2 BBOX1 HEL-S-44 PEX12 CYP8B1 PEX13 NEDD4 HALLMARK_MYC_TARGETS_V1%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 PSMC4 HEL-S-276 RPL34 PSMB2 PWP1 RPL6 UBE2L3 EEF1B2 CCNA2 HDAC2 FBL PSMD7 SNRPD2 TRIM28 TFDP1 HNRPR RUVBL2 PSMD3 PSMD1 SNRPD3 MYC TXNL4A RPS10 CDC45 EIF1AX STARD7 RPS5 RPL22 RPS6 HEL-S-69 UBE2E1 TUFM CLNS1A SNRPG ERH SRSF7 SNRPA SET SLC25A3 GLO1 CSTF2 PCBP1 NOP16 KARS1 CBX3 MRPL23 SFRS3 LSM2 SRPK1 AIMP2 LSM7 UBA2 TOMM70 RNPS1 HNRNPC HSP90AB1 RPLP0 PTGES3 YWHAQ C1QBP DHX15 VDAC3 HNRPA3 AP3S1 MRPL9 NCBP1 VBP1 PABPC4 CAD GNL3 TCP1 SNRPA1 PABPC1 HEL-S-91n DDX21 U2AF1 PPM1G SRM PSMB3 FAM120A EIF4H RPL14 RPS3 SNRPB2 COX5A RPS2 CCT7 CCT4 NDUFAB1 RRM1 IFRD1 SF3A1 SSB CNBP HEL-S-100n RSL1D1 AAG1 HNRNPA2B1 POLE3 PRPF31 SSBP1 TARDBP EIF4E EIF3B EIF4A1 RRP9 CDC20 RFC4 CDK4 CDK2 NHP2 HPRT1 NOLC1 ORC2 IARS PA2G4 EIF2S1 APEX1 HNRNPD HEL-S-97n NPM1 XPOT EIF3J ABCE1 EIF3D NCBP2 CTPS1 GOT2 HEL-S-133P MCM5 MCM6 MCM2 EIF2S2 PCNA COPS5 EPRS1 TRA2B TYMS POLD2 USP1 PSMA4 CANX H2AZ1 NOP56 RANBP1 ETF1 HSPD1 DUT HEL-S-69p RPL18 PSMC6 DEK IMPDH2 MCM7 HEL-S-68p HEL2 RAN MAD2L1 SNRPD1 SMARCC1 PSMA2 PRDX3 PHB2 CYC1 HALLMARK_KRAS_SIGNALING_DN%MSIGDBHALLMARK%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN TENT5C MX1 KRT13 SERPINB2 EGF GP1BA PTGFR ZC2HC1C PKP1 ATP6V1B1 EDN2 MEFV CD40LG PNMT FGF22 CLSTN3 ARHGDIG IRS4 PARK2 KRT1 NUDT11 KLK8 TGM1 TCL1A VPREB1 CAPN9 SLC16A7 DCC PDK2 CPA2 KRT4 SELENOP RYR1 ENTPD7 UGT2B17 CDKAL1 HEL-S-79 KRT5 SOX10 THNSL2 EDAR SCN10A HEL-S-75 CLPS KCNQ2 SIDT1 CALCB CPB1 TNNI3 KCNE2 SHOX2 ZBTB16 CACNA1F MACROH2A2 SLC5A5 HSD11B2 FGGY KCNMB1 KCNN1 PRODH SLC38A3 SPTBN2 MLL2 TFAP2B BARD1 DTNB AMBN HTR1D HTR1B FGF16 AKR1B10 IFNG IL5 TG GDNF BTG2 MYH7 STAG3 ARPP-21 CYP11B2 KLHDC8A CHRNG CD80 PCDHB1 TLX1 CD207 CACNG1 CPEB3 ZFP112 GPR19 RYR2 TENM2 IL12B MAST3 IGFBP2 SERPINA10 OXT SLC6A3 SKIL LFNG CCR8 EFHD1 LYPD3 INSL5 TSHB TAS2R4 GRID2 CAMK1D KCND1 PROP1 HEL-S-20 SPHK2 FSHB NGB COPZ2 SNN PAX3 TEX15 ADRA2C UPK3B WNT16 SSTR4 COL2A1 MYOT GTF3C5 TFF2 CELSR2 CLDN16 ITGB1BP2 CDH16 IFI44L GPRC5C SLC29A3 SPRR3 ITIH3 SMPX NPY4R PLAG1 ALOX12B CCDC106 ABCB11 NR1A2 P2RY4 RSAD2 VPS50 NRIP2 NTF3 SLC25A23 SNCB RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 P2RX6 NR6A1 NPHS1 EDN1 MYO15A SCGB1A1 YPEL1 PAX4 ASB7 MAGIX PDCD1 RGS11 SGK1 COQ8A BRDT HNF1A ABCG4 FGFR3 SYNPO TFCP2L1 IDUA CNTFR HALLMARK_PEROXISOME%MSIGDBHALLMARK%HALLMARK_PEROXISOME HALLMARK_PEROXISOME EPHX2 CRAT ABCB1 ABCD2 BCL10 HRAS TOP2A ABCC5 DHRS3 FADS1 FDPS ECI2 CTPS1 ATXN1 HEL-S-53e MLYCD PBR ACOT8 ACSL1 ACSL5 PRDX5 CADM1 SLC25A4 PABPC1 IDI1 SULT2B1 RDH11 HAO2 SLC23A2 SLC35B2 SLC27A2 HEL111 VPS4B DHCR24 CNBP PEX14 LONP2 ERCC1 SCGB1A1 ABCC8 ISOC1 DIO1 HEL-S-26 GNPAT RETSAT DKFZp667O1614 IDE STS NUDT19 PEX2 NR3A2 SLC25A17 PEX5 CRABP2 SEMA3C CTBP1 ABCB4 CRABP1 PEX11B CACNA1B SMARCC1 ABCB9 ELOVL5 CLN8 ABCD3 FIS1 FACL4 UGT2B17 ALDH9A1 SIAH1 LOC51064 CDK7 ABCD1 MSH2 DLG4 FABP6 ALB ACOX1 PEX6 EHHADH CLN6 HSD17B4 RXRG HSD17B11 HSD3B7 HSD11B2 NR1i2 HEL-S-44 MVP HMGCL PEX13 HALLMARK_MYC_TARGETS_V2%MSIGDBHALLMARK%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 HK2 MRTO4 HSPD1 SRM MPHOSPH10 PLK4 PA2G4 TMEM97 PLK1 EXOSC5 DUSP2 MYC NPM1 RRP9 MYBBP1A NOP16 CBX3 CDK4 AIMP2 RCL1 MCM5 NIP7 NOP2 PPAN DCTPP1 NOC4L RABEPK WDR43 UNG TCOF1 PES1 UTP20 FARSLA MAP3K6 PRMT3 WDR74 SORD NOLC1 IMP4 GNL3 TFB2M PPRC1 SLC19A1 BYSL LAS1L GRWD1 NOP56 NDUFAF4 HALLMARK_NOTCH_SIGNALING%MSIGDBHALLMARK%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING PSENEN NOTCH3 SAP30 TCF7L2 MAML2 HES1 FBXW11 FZD7 DTX1 CCND1 DTX2 PSEN2 DTX4 ST3GAL6 NR1C2 SKP1 FZD5 NOTCH1 RBX1 FZD1 LFNG NOTCH2 PRKCA KAT2A HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDBHALLMARK%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY PFKP ATOX1 HEL-S-112 HEL-S-128m SRXN1 MGST1 MPO NDUFA6 ERCC2 PTPA HHEX HEL-S-97n SBNO2 MBP CDKN2D EGLN2 TXNRD2 SELS GLRX2 OXSR1 TXN IPCEF1 SCAF4 JUNB PRNP MSRA FES FTL LAMTOR5 HEL-S-2a GLRX NQO1 GCLC GPX4 GCLM GPX3 ABCC1 HEL-S-44 HEL-75 NDUFB4 HALLMARK_UV_RESPONSE_UP%MSIGDBHALLMARK%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 MSX1 ALAS1 PDLIM3 ATP6V1C1 ATP6V1F TMBIM6 GLS HTR7 STARD3 HLA-F MAPK8IP2 CDC34 CHKA MRPL23 POLG2 HEL-76 PRPF3 SELENOW TYRO3 NPTXR UROD CHRNA5 CYB5R1 NKX2-5 NPTX2 CCND3 KLHDC3 GGH RAB27A EIF2S3 EIF5 NAT1 AGO2 FGF18 CDO1 ONECUT1 CLTB ARRB2 SPR SLC25A4 HYAL2 SIGMAR1 NUP58 TGFBRAP1 DDX21 MAOA WIZ SQSTM1 CLCN2 TAP1 RXRB DNAJB1 PPP1R2 EPCAM CREG1 MGAT1 E2F5 NTRK3 HSPA2 PLCL1 CDC5L CCK GRINA ATF3 CYP1A1 POLE3 AP2S1 YKT6 RRAD TFRC RFC4 PARP2 HMOX1 CDK2 TACR3 CCNE1 TARS1 SHOX2 EPHX1 ASNS BMP2 ENO2 BTG2 ABCB1 BTG1 FKBP4 CEBPG TCHH FEN1 H2AX CDKN1C FURIN IGFBP2 JUNB PPT1 IL6ST FOS CNP BTG3 RPN1 HEL-S-94n CASP3 COL2A1 AQP3 NFKBIA GPX3 IRF1 POLR2H IL6 OLFM1 SLC6A8 CYB5B BAK1 PPIF CXCL2 PDAP1 CDKN2B hEMMPRIN C4BPB DGAT1 HEL-S-87p DLG4 RET RHOB GAL SLC6A12 MMP14 TUBA4A SULT1A1 GRPEL1 FOSB LYN AMD1 HALLMARK_IL2_STAT5_SIGNALING%MSIGDBHALLMARK%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING MAFF NT5E SPP1 GBP4 MUC1 LRIG1 MYC IGF1R PTCH1 HEL-S-21 DHRS3 HEL-76 CD81 ENO3 RORA PLSCR1 CCND3 CCND2 GABARAPL1 AHR SERPINC1 ANXA4 CYFIP1 GUCY1B1 GPR65 IKZF2 PDCD2L IKZF4 SCN9A TNFRSF8 TNFSF11 CAPN3 SELL ENPP1 SLC39A8 IL1R2 TNFRSF4 SHE WLS SYNGR2 PRKCH S100A1 SWAP70 PRNP IL3RA FLT3LG LTB ADAM19 TNFRSF21 TWSG1 MAPKAPK2 GPR83 SOCS1 AGER SOCS2 CD79B IL10 PENK PLPP1 MAP6 SNX9 ICOS ARL4A POU2F1 TNFRSF1B IL2RA CCNE1 HOPX DRC1 CDC42SE2 PHTF2 CTSZ PTH1R ITGAE CD48 MYO1E GLIPR2 NCS1 PTGER2 NFKBIZ SH3BGRL2 CTLA4 SIAT4C LIF CCR4 BATF3 TNFRSF18 CKAP4 SERPINB6 BMP2 CDCP1 PTRH2 COL6A1 IL13 TLR7 ITGA6 IRF6 SMPDL3A IFITM3 MXD1 PLEC AHNAK CST7 COCH RRAGD IL1RL1 IL10RA PLAGL1 TNFSF10 LRRC8C ABCB1 DCPS CD83 PRAF2 CSF2 SPRY4 CSF1 HUWE1 P2RX4 ARHH TTC39B IL2RB SYT11 SNX14 ETFBKMT IL18R1 CDKN1C F2RL2 BMPR2 EEF1AKMT1 APLP1 FURIN MAP3K8 DENND5A MYO1C PHLDA1 HEL-S-66 IGF2R HIPK2 BHLHB2 BCL2L1 ETV4 CASP3 UMPS TNFRSF9 P4HA1 GPX4 RGS16 IFNGR1 PNP EMP1 GADD45B CISH HK2 SLC2A3 TRAF1 XBP1 ITGAV GATA1 SELP PIM1 NFIL3 AMACR ADFP BCL2 RHOB NOP2 KLF6 IRF4 BATF TIAM1 CDC6 CD44 IRF8 NRP1 UCK2 FGL2 HALLMARK_COAGULATION%MSIGDBHALLMARK%HALLMARK_COAGULATION HALLMARK_COAGULATION MAFF SERPINA1 CPQ PLEK HRG CTSO CTSH OLR1 SERPINB2 GP1BA F3 F8 RAC1 CD9 MMP15 F11 C1QA C1S C1R THBD SERPINC1 TMPRSS6 PLG FYN F10 HEL-S-62p ISCU APOC1 CFD KLKB1 KLF7 S100A1 KLK8 A2M PF4 MEP1A CAPN5 MBL2 SPARC SIRT2 MMP9 PLAT CLU COMP F2RL2 GDA MASP2 FURIN CPB2 PEF1 CFI PROZ GNG12 LEFTY2 TF PROC F13B ARF4 C8A RAA1 DUSP14 C8G VWF CTSK FGA MMP7 F9 DCT HEL-S-52 CASP9 MMP10 CRIP2 CPN1 PECAM1 P2RY1 SH2B2 MMP11 HEL-S-41 HTRA1 APOC3 APOC2 MSRB2 ANXA1 USP11 F2 TFPI2 BMP1 FBN1 ITGB3 TIMP3 NR2A1 TIMP1 LAMP2 PROS1 ITGA2 ADAM9 MMP2 SERPING1 MMP3 CFH C2 PRSS23 DPP4 MMP14 C9 S100A13 THBS1 GP9 GNB2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 KYAT1 ENOPH1 ADI1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A6 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) HSD17B12 FADS2 ELOVL5 EHHADH ELOVL2 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation GCDH ECHS1 ACAT2 ACAT1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5D ITPKA INPP5J BPNT2 INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 CAD NME2 CTPS2 NME3 CTPS1 NME4 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 TPH1 DDC AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis ACSL1 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 FADS2 ACSM3 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis DPEP1 ALOX12 LTC4S GSTM4 GGT5 GPX4 ALOX5 ALOX15 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 FDPS ACAT2 MVK ACAT1 GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation HGD TAT FAH HPD GSTZ1 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ADH4 MAOB ALDH3A2 ALDH2 TOMT MAOA ADH1B COMT ADH6 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II AMDHD2 NAGK GNPDA1 GNPDA2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair NAXE NAXD GAPDH URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PPIP5K1 PLCZ1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A IPMK INPPL1 PIP4K2B PTEN PIP4K2C SACM1L OCRL ITPK1 SYNJ2 ITPKB PLCB3 PLCB4 INPP5B ITPKC PIK3CA MINPP1 PIK3C3 PLCB1 INPP5A PLCB2 PI4K2A SYNJ1 IPPK MTMR3 PIK3R4 INPP5D ITPKA PIK3R3 PIK3R2 INPP5J PIK3R1 PIK3R6 INPP5K PIK3R5 PLCG2 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT2 GPT ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing TGM1 CERS3 ALOX12B CYP4F22 ALOXE3 PNPLA1 SLC27A4 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD UMPS DHODH GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation PNP GDA NT5C2 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis ISYNA1 IMPA1 IMPA2 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) MT-ND6 MT-ND4L COX7B NDUFA13 MT-ND4 MT-ND5 NDUFA11 NDUFA12 MT-CO1 COX4I1 NDUFA10 MT-ND2 COX6A1 COXFA4L2 MT-ND3 COX7C MT-ND1 UQCRFS1 COX8A NDUFC2 SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 UQCRC1 NDUFS3 NDUFS2 NDUFS1 COXFA4 MT-CO2 UQCRC2 MT-CO3 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB10 UQCRB NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A UQCRH NDUFV3 CYC1 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFA1 COX6C UQCRQ NDUFAB1 MT-CYB DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 PFAS AK8 NME3 ATIC GUK1 NME4 PPAT ADSL NME5 PAICS IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 GART AK1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMNAT1 NMRK2 NMRK1 NMNAT3 NMNAT2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt GLUD1 GAD1 GLUD2 GAD2 ALDH5A1 GLUL ABAT PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 UBIAD1 COQ4 COQ3 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis GMPS RRM1 RRM2 NME2 NME3 NME4 GUK1 NME5 IMPDH1 NME1 IMPDH2 NME6 RRM2B NME7 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 SHMT2 PSAT1 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME7 AK5 NME2 NME3 GUK1 NME4 NME5 DGUOK DCK NME1 NME6 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) DIO1 DIO2 UGT1A8 SULT1A2 SULT1A1 UGT2B11 GLUTAMINYL-TRNAGLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I SULT1A2 POR CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GSTK1 GSTM3 GSTM2 GSTM1 GSTO2 GSTP1 MGST3 MGST1 MGST2 GSTT2 GSTT1 NAT8 GGT5 GSTA5 GSTA4 GSTA3 GSTA2 ANPEP GSTA1 GSTM5 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate GART MTHFD1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation DTYMK NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis ALOX12 GPX4 ALOX15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1G1 ATP6V0B ATP6V0E1 ATP5PD VPS9D1 ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 ATP6V1A ATP5MC2 ATP5MC3 ATP5MC1 MT-ATP6 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP5MG ATP6V1D ATP6V1C1 ATP5MF ATP5ME ATP6V1F ATP6V0A1 ATPAF2 ATP5PF FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation FPGS MTHFD1 SHMT2 SHMT1 MTHFD1L L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASPG ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis GART PFAS PPAT PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK2 UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis SC5D DHCR24 DHCR7 LSS ACAT2 FDFT1 ACAT1 IDI1 FDPS MVK GGPS1 HMGCS1 IDI2 PMVK MVD HMGCR NSDHL HSD17B7 HMGCS2 SQLE LBR TM7SF2 EBP KCNH7 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP2 UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCL HMGCS2 BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation AKR1A1 CRYL1 DCXR D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation BCKDHA ECHS1 DBT ACAT2 BCKDHB ACAT1 BCAT1 ACADSB DLD HSD17B10 BCAT2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 ST3GAL6 B4GALNT1 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 UGT1A4 HMOX2 BLVRA PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis ST8SIA2 ST8SIA3 B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis FAR2 CHKB PCYT1B PCYT2 PCYT1A ETNK2 CHKA ETNK1 PEDS1 CEPT1 AGPAT1 SELENOI GNPAT AGPS FAR1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) HAAO GOT2 KMO ACMSD AADAT TDO2 KYNU AFMID KYAT3 DHTKD1 IDO2 ALDH8A1 IDO1 KYAT1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A6 CYP19A1 HSD17B1 HSD17B7 HSD17B3 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis B3GALT4 UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide ABO FUT2 FUT3 B3GALT5 B3GALT1 ST3GAL3 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III CYP2E1 AKR1B10 AKR1B1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME4 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2 ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis CBR1 PTGIS HPGD PTGES2 PTGES3 AKR1C3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES PTGS2 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation PIP4P2 PIP4P1 INPPL1 TPTE2 PTEN SACM1L OCRL INPP4A SYNJ2 INPP4B INPP5E INPP5B INPP5F SYNJ1 MTMR3 INPP5D INPP5J MTMR14 INPP5K ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis HSD17B12 ELOVL4 TECR COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis ALOX12 EPHX3 GPX4 ALOX5 ALOX15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP2E1 CYP4X1 CYP2A6 CYP2U1 CYP2S1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGIS HPGD PTGES2 PTGES3 PTGR1 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGES LTA4H PTGS2 EPHX3 CYP2D6 CYP2J2 CYP4F2 CYP4F3 ALOX15B DPEP2 GSTM4 GGT5 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI4 PADI1 PADI6 PADI3 PADI2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 ITPKB INPP5B ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K1 PPIP5K1 IP6K3 IPPK IP6K2 PPIP5K2 IPMK THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO2 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 OXCT1 BDH2 BDH1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3A1 ALDH3B2 ALDH1B1 ALDH3B1 PGM2 DERA ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX12 ALOX5 ALOX15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine MTR BHMT BHMT2 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation SULT1A2 POR CYP4X1 MAOA CYP2A6 CYP2U1 CYP2S1 CYP1A2 CYP1B1 SULT1A1 CYP2C19 UGT2B11 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD DHTKD1 ALDH8A1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX2 GPX1 GPX3 GSR GPX7 GPX4 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT1 NMNAT3 NAMPT NMNAT2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 AGPAT1 MBOAT2 ABHD5 AGPAT2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 BPGM FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis PCK1 FBP1 FBP2 BPGM GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 PC GAPDH G6PC3 GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I AOC2 MAOB ALDH3A2 ALDH2 MAOA AOC3 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II HSD17B12 TECR ELOVL1 ELOVL7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) ACSL1 HSD17B12 ACSM6 ACSBG1 ACSM5 ACSM4 SLC27A2 ACSBG2 ELOVL7 FADS1 FADS2 ELOVL5 ACSM3 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle GGCT GCLC GSS GGT5 OPLAH GCLM CNDP2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 MGAM HKDC1 PYGM PYGL PGM1 GCK HK2 HK1 PGM2 PYGB L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation BCKDHA ECHS1 DBT BCKDHB BCAT1 DLD ACAD8 ALDH6A1 ABAT BCAT2 HIBADH HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) NTAQ1 APEH NTAN1 METAP1 METAP2 ATE1 NAA20 NAA25 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1L1 GOT1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 HKDC1 PGM1 GCK HK2 HK1 PGM2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B TSEN2 C2orf49 TSEN54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage TK2 TK1 CDA TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis DTYMK DUT RRM1 RRM2 NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA1 GSTP1 GSTA5 GSTA4 GSTA3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B GDA NT5C2 XDH IMPDH1 IMPDH2 ADA L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT2A MAT1A MAT2B AHCY CBS CTH L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle APIP MRI1 MTAP KYAT1 ENOPH1 MAT2A MAT1A MAT2B SRM ADI1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A INPP5F SYNJ1 IMPA1 IMPA2 INPP5J BPNT2 INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMPR1B ACVR2A SKI SMAD4 BMP2 BMPR2 ZFYVE16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP1 GGT3P LTC4S LTA4H GSTM4 GGT5 DPEP2 ALOX5 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B2 HSD3B1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1 GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II RBP4 RBP5 RBP1 XDH GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation MAOB ALDH3A2 SULT1A3 MAOA COMT MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX12 EPHX3 ALOX15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1L1 GOT1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHC LDHB LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III MAOB ALDH3A2 ALDH2 ALDH3A1 ALDH3B2 MAOA ALDH1B1 ALDH3B1 SAT2 SAT1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKM CKMT1B CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation BCKDHA DBT MCCC2 BCKDHB AUH BCAT1 IVD MCCC1 DLD HMGCLL1 BCAT2 HMGCL GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASPG ASRGL1 GOT1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation SULT1A2 ALDH3A2 ALDH2 SULT1A3 MAOA ADH1B ADH6 SULT1A1 UGT2B11 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK2 ADSS2 AK3 AK4 AK5 AK7 AK8 ADSL AK1 ADSS1 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde HAAO KMO TDO2 KYNU AFMID IDO2 IDO1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLAAT3 PLAAT2 PLAAT5 PLCG1 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLA2G6 PLCH1 PLD1 PLB1 PLCH2 PLD3 PLCD3 PLD2 PLCD4 OC90 PLCD1 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLA2G4E PLA2G4B PLA2G4C PLA2G2A PLA2G4A PLA2G10 PLCZ1 PLCE1 PLCB3 PLCB4 PLCB1 PLCB2 PLCG2 PLAAT1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis FDFT1 SQLE CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK2 PANK3 PANK1 PPCS COASY PPCDC SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation TKFC SI KHK ALDOC ALDOB TPI1 ALDOA PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage DTYMK NME2 NME3 NME4 NME5 TYMS DCK NME1 NME6 NME7 TK2 CMPK1 TK1 CMPK2 CDA PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis CHKB PCYT1B PCYT1A CHPT1 CHKA CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization MAOB ALDH2 MAOA ADH1B ADH6 NMNAT1 NMNAT3 TPH2 NMNAT2 TPH1 DDC AANAT ASMT CYP2A6 AKR1A1 HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID ALDH3A2 SULT1A3 DHTKD1 IDO2 QPRT ALDH8A1 NADSYN1 IDO1 SULT1A1 UGT2B11 SULT1A2 POR CYP4X1 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2C19 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) ACAA1 HADH ACSBG1 ECHS1 SLC27A2 ACSBG2 HSD17B10 SCP2 ACOX2 ACOX1 EHHADH HSD17B4 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine AKR1A1 MAOB ALDH3A2 DDC TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 GARS1 LARS2 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I AMDHD2 GNPDA1 GNPDA2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage AK2 GMPS AK3 RRM1 AK4 RRM2 AK5 AK7 NME2 AK8 NME3 GUK1 NME4 ADSL NME5 IMPDH1 NME1 IMPDH2 NME6 ADSS1 RRM2B ADSS2 NME7 ADK APRT HPRT1 PNP AK1 ADA SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP DTYMK RRM1 RRM2 DCTD NME2 NME3 NME4 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME7 CMPK1 CMPK2 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine DMGDH CHDH ALDH7A1 SHMT2 SHMT1 BHMT TCA CYCLE%BIOCYC%PWY66-398 TCA cycle FH SDHC IDH3G DLST SDHD SDHA CS DLD SDHB SUCLA2 IDH3B OGDH SUCLG2 SUCLG1 ACO2 MDH1 IDH3A MDH2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation HADH HADHB ACSBG1 HADHA ECHS1 ACAA2 ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis KDSR SPTSSA CERS1 SPTLC1 SPTLC2 SPTLC3 DEGS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C ADH1B SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis FUT2 B3GALT5 UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) HAAO GCDH ECHS1 KMO ACAT2 ACMSD ACAT1 TDO2 KYNU AFMID DHTKD1 IDO2 ALDH8A1 IDO1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I ALDH1A3 SDR16C5 ALDH1A2 ALDH1A1 RDH16 RBP4 RBP5 RBP1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST8SIA2 FUT6 FUT5 FUT9 CHST1 B4GALT2 B4GALT3 B4GALT1 ABO FUT3 FUT1 ST3GAL4 ST3GAL3 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME7 CMPK1 CMPK2 NME2 NME3 NME4 NME5 NME1 NME6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPP2 UPP1 UPB1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO2 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) ACSL1 ACSM6 ACSM5 ACSM4 FADS2 ELOVL5 FADS1 ACSM3 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4GALT3 B4GALT1 B3GNT2 GCNT2 GCNT3 B4GALT2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis BPGM PKLR GPI PFKL TPI1 PKM PFKM PFKP PGAM1 PGAM2 ENO1 ENO2 ENO3 GAPDH GAPDHS PGK1 ALDOC ALDOB PGK2 ALDOA HK3 HKDC1 GCK HK2 HK1 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4GALT1 LALBA FUT2 ST6GALNAC6 FUT3 B3GALT5 B3GNT2 B4GALT4 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5E PNP NT5C2 XDH IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle CPT1A CPT2 SLC25A20 CPT1C CPT1B EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) ACSF3 MCAT NDUFAB1 OXSM ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis FUT2 B3GALT5 FUT1 UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 TREH GCK HK2 HK1 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX3 CYP2C9 EPHX2 EPHX1 EPHX4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RBP4 RBP5 RBP1 RDH8 DHRS3 RLBP1 RPE65 DHRS4 RBP2 RDH12 DHRS9 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B2 HSD3B1 AKR1C3 CYP17A1 HSD17B3 SRD5A2 SRD5A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME7 GMPS NME2 NME3 GUK1 NME4 NME5 IMPDH1 IMPDH2 NME1 NME6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis RBP4 RBP5 RBP1 RDH8 DHRS3 DHRS4 RBP2 RDH12 DHRS9 RDH11 RDH10 LRAT CES5A CES4A LIPC BCO1 CES2 PNLIP CES1 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis ALOX12 PTGS2 EPHX3 CYP2D6 GPX4 ALOX5 ALOX15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II HK3 GALE PGM3 HKDC1 GNPNAT1 UAP1 GCK HK2 HK1 GPI GNPDA1 GNPDA2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis ACSL1 HSD17B12 ACSBG1 ELOVL6 SLC27A2 ACSBG2 ACOT2 ELOVL7 ACOT7 ACOT1 ACOT4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 GOT2 HOGA1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F2 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) HSD17B12 FADS2 ELOVL5 ELOVL2 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACSL1 ACSBG1 SLC27A2 PTGR1 ACSBG2 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PNP PGM2 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation TYMP CDA UPP2 UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PIP4P2 PIP4P1 PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis AKR1C1 AKR1C2 AKR1C4 AKR1C3 SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I MTR MTHFD1 ALDH1L1 MTHFD2 SHMT2 MTHFD2L MTHFR SHMT1 MTHFS ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK3 GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT2A MAT1A MAT2B AHCY ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP HPRT1 ADA REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX2 GPX5 GPX1 GPX8 GPX3 GPX7 CAT SOD2 SOD3 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C3A NT5E NT5C1A PNP NT5C1B NT5C2 XDH ADA ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP2E1 AKR1B10 CYP4X1 CYP2A6 CYP2U1 CYP2S1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 SHMT1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 OCRL ITPK1 SYNJ2 ITPKB INPP5B ITPKC INPP5A SYNJ1 IPPK INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX12 ALOX15B GPX4 ALOX5 ALOX15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 DAGLA LPL CEL LIPF LIPE LIPG PNPLA3 PNPLA4 DAGLB PNLIPRP3 PNPLA2 LIPC PNLIP CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 PFKFB4 TIGAR PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) DHFR2 SHMT2 TYMS ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2B NME7 RRM1 RRM2 NME2 NME3 NME4 NME5 NME1 NME6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 NMNAT3 NMNAT2 QPRT NADSYN1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) HSD17B12 FADS2 ELOVL5 ELOVL7 ELOVL2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4GALT3 ST8SIA2 B4GALT1 ST6GAL2 ST3GAL4 B3GNT2 GCNT2 GCNT3 ST3GAL3 ST6GAL1 B4GALT2 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III CYP2E1 CYP2G1P ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ALDH3A2 ACSS3 ALDH2 ACSS2 ACSS1 ADH1B 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation BCKDHA DBT MCEE BCKDHB PCCA PCCB MMUT DLD LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP2G1P UGT1A4 FMO2 FMO3 FMO4 UGT2B11 FMO5 AOX1 FMO6P CYP4X1 CYP2A6 CYP2U1 CYP2S1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALE GALT GALM GALK1 PGM1 PGM2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II HK3 PGM3 HKDC1 GNPNAT1 UAP1 GFPT2 GFPT1 GCK HK2 HK1 GPI L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT2 GPT INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) AADAT ALDH7A1 AASS DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation SLC27A2 ALDH3A2 PHYH HACL1 ACSM1 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis FDPS GGPS1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1 LCMT2 TYW3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I PLAAT2 GDE1 PLAAT5 NAPEPLD PLA2G1B ENPP2 PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ECHS1 ACAT2 ACAT1 ACADSB ACSM1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis HAAO NMNAT1 KMO TDO2 NMNAT3 KYNU NMNAT2 AFMID IDO2 QPRT NADSYN1 IDO1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation ACSL1 ACSBG1 ACSL3 SLC27A2 ACSBG2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis PLCB1 DDHD1 DAGLA DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) HEMK2 SLC34A2 PNP TRMT112 SLC20A2 SLC20A1 AQP9 SLC2A1 AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2A6 CYP2U1 CYP2S1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I UGP2 PGM1 PGM2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB PMM1 PMM2 GMPPA GPI MPI CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SC5D DHCR24 DHCR7 LSS FDFT1 NSDHL HSD17B7 SQLE LBR EBP TM7SF2 KCNH7 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) DMGDH SHMT2 SHMT1 BHMT SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis HMBS FECH UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation SDS BCKDHA DBT BCKDHB SDSL DLD GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS2 NOS3 NOS1 ASL ASS1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation BCKDHA DBT CDO1 BCKDHB MCEE PCCA PCCB MMUT DLD BHMT BHMT2 SUOX MTR GOT1 MAT2A MAT1A MAT2B AHCY CBS CTH TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis HMBS ALAD ALAS2 ALAS1 UROS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II PPCS FMO1 ADO ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis LCLAT1 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 GPAT3 GPAT2 MOGAT3 PLPPR2 PLPPR3 PLPPR4 MOGAT1 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis MINPP1 IPMK ITPK1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis PNMT TH DBH DDC 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1 TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I CDO1 FMO1 CSAD ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle MDH2 GOT1 MDH1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 CCNH AHR HEL-S-89n HEL-S-125m UXT CCND3 KAT5 CCND1 ZMIZ1 ZMIZ2 EP300 KAT7 GTF2F1 GTF2F2 RUNX2 TLE5 PIAS1 CDC25B CCNE1 CDC37 PRKD1 IL6ST SF1 PXN PIK3R1 HEL-S-67p BRINP1 BAG1 LPXN PATZ1 MAGEA11 JUN SMAD4 POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 FHL2 PTEN EFCAB6 BRCA1 CASP8 SIN3A CASP3 TRIM68 RAC3 NELFCD APPL1 PELP1 TGIF1 NCOA1 HEL-S-102 PARP1 NCOA6 PRMT1 HEL-S-72p ETV5 SENP1 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RCHY1 RNF4 NR2C2 HEL-S-99n EGFR RELA PSMC3IP NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK3 SHC4 NTRK1 GSK3B NTRK2 IRS1 SHC1 MAPK9 MAPK8 MAPK7 PTK2B MAPK1 FOXO3A PLCG1 RAF1 CCR1%IOB%CCR1 CCR1 PXN MAPK14 NFKB1 RELA CREB3 ZAP70 GNA14 CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL16 CCL26 MAPK3 CCL15 CCR1 CCL14 CCL23 SRC STAT1 CCL3L3 CCR5%IOB%CCR5 CCR5 CCL14 CCL13 CCL11 C5AR1 AFP PIK3R1 RELA HEL-S-15 IKBKB CCL8 CCL7 CCL5 CCL4 CCL3 PTK2B MAPK1 CCL2 CCR5 MAPK3 CHUK SYK STAT1 STAT3 MAPK14 NFKBIA GRB2 PTPN6 CCL26 CCR7%IOB%CCR7 CCR7 PLCG1 CCL19 MAPK3 GSK3B CCL21 ADRB2 MAPK14 FOXO1 MTOR RELA HEL-S-15 MAPK8 RPS6KB1 PTK2B MAPK1 CCR7 FOXO3A CCR9%IOB%CCR9 CCR9 MAPK3 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 CD226 ITGB7 MADCAM1 EZR HEL70 CD40%IOB%CD40 CD40 MAPK9 MAPK8 LCK MYC PLCG2 MAPK1 FYN JAK3 MAPK3 LYN JUN MAP2K1 CHUK SYK STAT3 PIK3R1 MAPK14 c-fgr IKBKB NFKBIA CXCR4%IOB%CXCR4 CXCR4 PLCG1 MAPK3 LYN STAT5B FYB1 VCAM1 BAD STAT1 STAT2 LIMK1 STAT3 PTPN11 NFKB1 NFKBIA PTPRC CXCL12 ARHA RPS6KB1 ACKR3 PTPN6 ATF1 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA2 HEL-S-1 FOXO3A RAC1 CCR5 JAK3 NCK1 MAP2K3 MAP2K1 MAP2K2 CHUK HEL-S-72p RPS6 VAV1 VAV2 DOK1 NR3A2 ZAP70 CREB1 LCK TFF2 LCP2 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL EGFR GNAI1 RELA HEL-S-15 GNA13 INPP5D PLCG2 STAT4 PTK2B MAPK1 FYN EGFR1%IOB%EGFR1 EGFR1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 PRKCZ MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR PTK6 BRAF CDC2 SMU1 CYLD TRIP6 SDC1 GRB2 CALM1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 ADRBK1 AP2S1 FLNB CD59 RPS2 LDLR MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 STAT3 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 PRAG1 CTNND1 INPPL1 ARHGAP35 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA SH3GL2 KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 STAM2 PHLDB2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 FLOT2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK DOCK1 MET SOS2 SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 SRC RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 MAPK3 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 PTPN11 PPP2R3A BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI PRKCB ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 EPO%IOB%EPO EPO GSK3A FOXO4 FOXO1 CRKL RPS6KA5 H2BC21 MAPK1 FOXO3A SH2B2 MAPK3 STAT5B JUN MAP2K1 MAP2K2 SYK BAD STAT3 PTPN11 BRAF EPOR MTOR VAV1 HCLS1 RAF1 SGK1 FAS%IOB%FAS Fas RIPK2 ANXA4 UBE4B TRAF2 CSNK1E TRAF1 LCK TRAF3 CSNK2B TCP1 BTK MET PLEC GTF3C3 PARG ROCK1 UBA7 MAX PRKDC DIABLO SATB1 USO1 GLRX STK4 DEDD2 CDC42 MAPK1 FYN RIPK1 CD59 FADD EIF4B DEDD MAPK3 LYN MBD4 CASP8AP2 TIA1 CSNK1A1 EIF2AK2 BMX EIF2S1 HEL-S-283 WEE1 TNFSF6 STK24 NEDD4 EIF3J BCL2 FAS BAX PKN2 PTPN6 PKN1 BCL2L1 GSK3B NUMA1 FAF1 HEL113 PARK2 TIAL1 CASP9 CASP8 AIFM1 CASP6 CASP10 FASTK CASP3 ARHGDIB XPO5 CASP4 CDC27 CASP2 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 PARP1 CSNK2A1 RFC1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 LYN ATF1 CEBPA ATF2 JUN CREB1 FLT3 STAT3 MAPK1 GAB2 CBL MAPK3 G-CSF%IOB%G-CSF G-CSF MAPK14 LCK CDK2 IL3RA REL GRB2 CSF3 POM121 CDKN1B CSF3R PLA2G1B SHC1 CBL SOCS3 FTH1 INPP5D RPS6KA1 MAPK1 JAK1 MAPK3 LYN STAT5B PRKCI CISH SYK STAT1 STAT3 PTPN11 CSNK1E HEL-S-44 SYP TYK2 GAB2 GDNF%IOB%GDNF GDNF FYN RAF1 CRK MET RET JUN MAP2K1 MAP2K2 PXN CDC2 NFKBIA DOK1 RPS6KA3 RPS6KB1 TH PTK2B GM-CSF%IOB%GM-CSF GM-CSF GSK3B GSK3A CSF2 CRKL IKBKB RPS6KA2 SPTAN1 MAP2K3 MAP2K1 MAP2K2 CHUK SYK HEL-S-269 HEL-S-69 PRKCA VAV1 TGFBR3 CREB1 HNRNPH1 PFN1 RAF1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 GANAB MAPK8 MAPK1 PLCG1 SH2B2 MAPK3 MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 MAPK14 NFKBIA PTPRC RPS6KB1 FES GRB2 PTPN6 HEDGEHOG%IOB%HEDGEHOG Hedgehog HEL2 DHH HHIP IHH ARRB2 GLI3 MED12 SHH CCNB1 ADRBK1 SUFU BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 SMO CTNNB1 GAS1 ID%IOB%ID ID ID3 HES1 TCF3 ATF3 MYF5 RB1 TCF7L2 PAX5 ELK3 RBL2 RBL1 PSMD4 ID2 MYOD1 CDK2 ID1 ID4 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 EIF4EBP1 STAT4 EIF4B JAK1 MAP2K6 IFNAR2 MAP2K3 MAP2K4 STAT5B STAT1 STAT2 RPS6 STAT3 TYK2 MTOR VAV1 NFKBIA ZAP70 ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma MAPK14 CBL EGFR CRKL HOXA10 MAPK11 MAPK8 IRF1 IRF2 PLCG2 IRF8 MAPK1 PRKCQ RAF1 CRK JAK1 MAPK3 CEBPB SPI1 IFNGR1 STAT1 STAT3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor IL7R MAD2L1 PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 PRKCB RPS6 MATK PRKCA DOK1 PIK3CA KIT RAF1 SOS1 CRK GRB7 SHC1 SRC WAS CSF2RB PIK3R2 PIK3R1 CBL RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN PLCG1 SOCS6 SOCS4 SOCS5 LYN STAT5B JUN YES1 STAT1 PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR KITLG TEC RPS6KB1 FES GRB2 GRAP LEPTIN%IOB%LEPTIN Leptin RPS6 STAT3 PIK3R2 PTPN11 PIK3R1 SLC2A4 MAPK14 EGFR RPS6KB1 SP1 LEP LEPR PDE3A MAPK1 GRB2 ITGAV SOCS7 JAK3 MAPK3 KHDRBS1 ITGB5 IRS1 PRKCE M-CSF%IOB%M-CSF M-CSF STAT3 INPPL1 HEL113 GAB3 PTPN11 PIK3R1 CBL ETS2 CASP8 PSTPIP2 INPP5D GRAP2 PTK2B GRB2 RIPK1 MAJN FADD CSF1R STAT5B CSF1 SHC1 NGF%IOB%NGF NGF PRKCI MAP2K1 CREB1 SP1 MAPK1 FRS2 MAPK3 NOTCH%IOB%NOTCH Notch GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 POFUT1 SIN3A MAGEA1 EP300 CCN3 SKP2 SKP1 PSENEN HES6 FBXW7 SAP30 RBX1 NCOR2 KAT2B NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 HDAC1 LEF1 PSEN2 DTX1 FURIN PSEN1 RELA DLL3 DLL4 APH1B MAPK1 CIRSR HES1 HIVEP3 MAPK3 SPEN JAG2 SMAD1 SMAD4 STAT3 NFKB1 ITCH SNW1 TCF3 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor FOS TGFBR1 PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 RBL1 TFDP1 EIF3S2 TFDP2 STRAP CRK CD44 ENG YAP1 ROCK1 HDAC1 LEF1 FZR1 MAPK8 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 MAPK3 NFYA NR1i1 NFYB NFYC MAPK14 PML FKBP1A SKI MAP3K7IP1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 FOXO3A SOX9 BTRC JUNB MAP3K7 VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 PRKCB FOXH1 RUNX2 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 HGS ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDC2 CDK6 COPS5 SNW1 CDK4 SP1 CDK2 DYNLRB2 DCP1A TP73 CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 TGIF1 NCOA1 HEL-S-72p THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3A MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK NCK1 MAPK3 GRB7 STAT5B MAP2K1 MAP2K2 SHC1 MAPK14 BMX PAK1 FES MAPK1 RAF1 TNFALPHA%IOB%TNFALPHA TNFalpha BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 NFKB2 SMARCA4 CDK9 NFKBIA COPS5 REL ALPL TAB3 NFKBIE MAP3K14 MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP IKBKB PPP6C CASP8 YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 CHUK PEG3 SYK ACTL6A TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 RASA3 TRAF4 MUXA POLR1A TRAF3 TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 BIRC2 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELA RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H POLR2L MAPK3 MAP3K2 SMARCE1 MAP3K1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 GLB1 TNIP2 PRC1 PSMC1 PDCD2 TBKBP1 PKN1 RB1 RPL4 RPL30 HEL2 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 AZI2 BTRC KPNA3 MAP3K7 RPS13 GTF2I SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A PRKCZ GLG1 TNFSF1%IOB%TNFSF1 TNFSF1 JUN TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 LTBR IKBKG TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B NFKB1 RELA NFKB2 RELB TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTB LTBR TNFSF8%IOB%TNFSF8 TNFSF8 NFKB1 RELA NFKB2 RELB TRAF3 REL MAPK1 TNFRSF8 TRAF1 TRAIL%IOB%TRAIL TRAIL AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 CASP2 RIPK1 BAK1 IKBKG FADD MAP3K7 MCL1 MAPK3 PARP1 CSNK2A1 APAF1 TNFRSF10C TNFRSF10B TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 CYCS BAX ATM DAP3 H2AX BEX3 PRKAA1 PRKDC DIABLO SRC TRADD TNFRSF11B BCL10 CBL RELA CASP8 WNT%IOB%WNT Wnt CSNK1A1 FZD4 WNT3A FZD7 FZD9 NFATC2 WNT7A FZD8 BCL9 CDK6 APC ARHA CTNNB1 PIN1 TCF4 GSK3B GSK3A DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RSPO1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 HEL-S-28 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A CTBP1 LEF1 LRP5 NLK MESD LRP6 PPP2CA MAPK8 FRZB DVL1 DVL2 GPC3 DVL3 WNT1 WNT3 WNT4 FZD1 SMAD1 TCF7L2 GCKR JUN FZD3 YES1 JUP FZD5 SETDB1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY SP3 MZF1 HDAC1 SP1 MAX WT1 MYC PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY MYC SGMS1 SHC1 PIK3R1 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYB FOXO3A RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 IL2 NFKB1 MTOR RPS6KB1 PIK3CA LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY HEL126 SIRT1 HIC1 CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 CCNE2 TFDP2 CCNE1 MCM3 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C HEL25 CDKN2A CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 HDAC1 SP1 MYC RB1 CDKN1A CDKN1B ORC1L TRRAP BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TK1 TOPBP1 SULT2A1 APAF1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY EGFR PERP TP53INP1 SPP1 DROSHA PMS2 BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 POU4F2 PML APC RFWD2 CARM1 CCNG1 FAS BAX CEBPZ SP1 BCL2 BCL2L1 RB1 CDKN1A TRRAP EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 STEAP3 CCNK HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TAP1 TSC2 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B BCL2L14 PLK3 JUN GADD45A SH2D1A TNFRSF10C LIF TNFRSF10B TNFRSF10A TNFRSF10D SMARCA4 TADA2B RGCC TP53I3 BCL6 JMY MDM2 SNAI2 BCL2L2 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 CASP6 AIFM2 BDKRB2 DGCR8 ZNF385A DUSP5 GPX1 EDN2 PRMT1 MMP2 SERPINB5 DDB2 RNF144B VCAN RRM2B MET HDAC2 PCNA BCL2A1 TYRP1 TAF9 HTT RPS27L PPM1J NLRC4 AFP RCHY1 PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN ATRIP RFC3 RFC4 FANCM FANCL FBXW11 RFC2 RMI1 ATM TOP3A XRCC3 RPA1 FANCA MRE11A HUS1 FANCC FANCB FANCE PALB2 FANCG BRCA1 FANCF RAD50 FANCD2 UBE2T RAD17 RAD1 FAN1 ATR TOPBP1 CENPS RAD9A BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY NFATC2 PRKCA NFATC1 CABIN1 PPP3CA PPP3CC CAPNS1 CAPNS2 CALM1 MEF2D HDAC1 HDAC2 EP300 PRKCB BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 EP300 MED1 RXRA CREBBP LPL PPARG PPARGC1A PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY PPP1R15A PML YAP1 HEL2 SHC1 ZFYVE9 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 MAP3K7 SKIL RNF111 SPTBN1 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 PDPK1 SMURF1 AXIN1 RPS6KB1 WWP1 TGFBR1 TGFBR2 FKBP1A TGFBR3 MAP3K7IP1 GRB2 ITCH SOS1 ZFYVE16 ARHA BAMBI STRAP CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY ACTN1 FZD7 PRKCA FGF7B F2 NUDT16L1 MMP9 CXCL12 TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP MDK CCL5 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY ADCY1 LPAR4 ADCY8 ADCY6 CREB1 ADCY9 GNAL RPS6KA5 PRKCE ADCY3 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY RAPGEF1 ITGAV PIP5K1C TLN1 CRK NECTIN3 NECTIN2 PIK3CA NECTIN1 CTNNB1 FARP2 PIK3R1 SRC ITGB3 PTPRM IQGAP1 F11R CLDN1 VAV2 CDC42 AFDN RAC1 RAP1A CTNNA1 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY TACC1 KIF20A tmp_locus_29 HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 CENPA AURKC SMC4 ARHA AURKB MYLK SMC2 AURKA PPP1CC SGOL1 NPM1 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY KNS2 RALA CLTC CTNND1 SLC2A4 ASAP2 ADRB2 PLD2 INS EDNRB ITGA4 EXOC7 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR ACAP1 BIN1 AGTR1 EXOC4 ITGA7 EXOC3 ITGA6 EXOC6 EXOC5 EXOC2 VAMP3 CTNNA1 EXOC1 ARF6 ITGAV PIP5K1C IL2RA CTNNB1 ITGB1 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY SMAD2 SMAD4 MAP2K1 TGFB1 MAPK3 TGFBR1 TGFBR2 MAP3K7IP1 APC ZFYVE9 EP300 MAP3K7 SKIL CREBBP PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY EGFR PRKCA SFN RXRA HEL2 SHC1 PIK3R1 ITGA6 RAC1 COL17A1 LAMA5 ITGB4 LAMA4 RPS6KB1 LAMC2 PIK3CA MST1R LAMC1 RXRB ERBB3 YWHAQ GRB2 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 ITGB1 EGF LAMB2 MET LAMA1 LAMB1 LAMA3 YWHAZ IL1A PMP22 CD9 BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN EFNB2 EFNB1 PAK1 NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 EPHB3 NCK1 SHC1 TF PIK3R1 SYNJ1 SRC KRAS CDC42 RAC1 HEL-S-31 RAP1A MAP2K1 MAPK3 CRK PIK3CA GRB2 HRAS PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY PIN1 SKP2 CDKN2A AXIN1 KAT2A MAX MYC PML TRRAP GSK3B TAF12 FBXW7 PPP2CA TAF10 TAF9 ACTL6A PPP2R5A SUPT7L KAT5 RUVBL2 RUVBL1 BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADCY1 RAP2B PRKAR1B PRKAR1A PTGER1 PRKACG PLCE1 ADRB2 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CXCL12 CREB1 TF MCL1 CREBBP TFRC EPO CITED2 HEL-S-30 BHLHE41 ADM RORA ENO1 HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p NPM1 ADFP TFF3 ABCG2 ENG HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 HEL-S-133P CP GCK NCOA1 JUN VEGFA PFKL COPS5 SP1 LEP ID2 TERT SMAD4 CXCR4 EP300 ABCB1 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY NFKB1 PIK3CA LCK CSNK2A1 SYK CSNK2A2 MAPK14 IKBKB PIK3R1 NFKBIA SRC CSNK2B ARRB2 REL RELA BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY ITGB1 LYN SELP ACTA1 EPHA4 FYN EPHB1 PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY EGFR BTC TGFA NRG3 NRG4 ERBB4 HBEGF ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY PRKCA JUN ADCY9 EDNRB GNAL MAPK1 PRKCE ADCY3 ADCY1 ADCY8 MAPK14 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 CRK GNAZ GNAI3 GNAI1 GNA14 EDNRA MAPK8 GNA15 GNA11 EDN2 KPG_011 PTK2B HRAS TRPC6 ARHA MAP2K2 PRKCH EDN3 GNAO1 EDN1 SLC9A3 FOS PLCB3 COL3A1 COL1A2 PRKCQ RAF1 PLCB1 PLCB2 PRKCB BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY XDH TNF NFKB1 RELA GPX1 HEL-75 HEL-S-64p CXCL8 HEL-S-44 BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY TNF IL10 IFNA1 IL2 IFNB1 IL15 IL13 IL18 IL16 IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A CXCL8 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY MAP2K6 TNF NFKB1 JUN MAPK8 MAP2K3 ATF1 MAPK14 MAP4K2 IKBKB MAP2K4 NFKBIA MAP3K1 CHUK CRADD RELA TRADD TRAF2 TANK TNFRSF1A CASP2 RIPK1 IKBKG MAP3K14 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY EGLN2 CDKN2A HIF3A EGLN1 RBX1 EGLN3 OS9 ARD1A VHL ELOC HIF1AN COPS5 HIF1A PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY GRB7 TNF PXN F2 PAK1 PLD2 MAPK1 NCK1 MAPK14 SHC1 PIK3R1 AGTR1 RELA FYN RAC1 PTPN11 MAPK3 NFKB1 CRK RPS6KB1 PIK3CA FOXO1 MAPK8 GRB14 ANGPT4 STAT5B GRB2 ANGPT2 ANGPT1 MMP2 BMX ELF1 CDKN1A ELF2 FES ITGB1 PLG FGF2 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CCNB1 CDC2 ATM GADD45A YWHAQ CDKN1A CDKN2D PRKDC PLK1 BRCA1 MYT1 CDC25B WEE1 MDM2 CDC34 CHEK2 EP300 RPS6KA1 ATR CHEK1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY MAP2K1 MAPK3 IL3 STAT5B GRB2 SOS1 HRAS SHC1 FOS RAF1 CSF2RB IL3RA PTPN6 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY RASGRF1 DAB2IP PRKCA RASAL1 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 PLCE1 NF1 RIN1 NRAS SOS2 RRAS GRB2 SOS1 PRKCE HRAS KRAS PRKCZ PRKCB RASGRF2 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY MAP2K1 MAPK3 IL2 LCK IL2RA JUN MAPK8 IL2RB STAT5B GRB2 SOS1 CSNK2A1 HRAS SYK SHC1 FOS IL2RG RAF1 JAK3 JAK1 PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS JUN CHRNA1 DOCK7 PIK3CD MAPK1 PIK3R3 PIK3R2 MAPK9 CHRNE BAD SHC1 STAT3 PIK3R1 NFATC4 SRC RNF41 KRAS MAPK10 NF2 CDC42 NRG1 RAC1 NRG2 MAP2K1 PTPN11 MAPK3 MTOR PIK3CA MAPK8 ERBB3 GRB2 ERBB2 SOS1 HRAS MAP2K2 FOS RAF1 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY DDX5 CCNB1 CDC2 PRKACG PPP2CA PRKAG1 AKAP8 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY CCNA2 IL4 SP1 MYC SHC1 PIK3R1 IL2RG PRF1 CCND2 FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 BCL2L1 ELF1 CCND3 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY PDGFRA RAPGEF1 CAV3 ITGAV SHB CRKL SHF CRK PLCG1 PIK3CA JUN GRB2 SOS1 IFNG CSNK2A1 SHC1 PIK3R1 FOS JAK1 PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY RAPGEF1 CRKL LRPAP1 VLDLR PIK3CA CBL LRP8 GRIN2B MAPK8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 MAP3K11 CDK5R1 ITGB1 PAFAH1B1 PIK3R1 GSK3B FYN RAP1A BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY CREB1 MAX RPS6KA5 MYC MAPK14 SHC1 MAP2K4 MAP3K1 TRADD TRAF2 MAP3K7 CDC42 RIPK1 RAC1 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS ATF2 HSPB2-C11orf52 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY RB1 CDC2 MYT1 CDC25B WEE1 CDK2 ATM CDK4 CHEK1 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY DOCK1 PAK1 JUN MAPK1 STAT3 PIK3R1 ACTA1 RAP1A PTEN RAPGEF1 MAP2K1 PTPN11 MAPK3 CRKL CRK PIK3CA MAPK8 GRB2 SOS1 PTK2B HRAS MAP2K2 ITGB1 MET FOS HGF RAF1 MAP4K1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 COL4A6 COL4A5 REN AGTR2 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CCNB1 PRKAR1B CDC2 PRKAR1A PRKACG TSG101 CD3G CD3E CD3D HEL-S-89n UHMK1 MAPK13 CD2 RB1CC1 CAMK4 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY MAP2K6 RALA LCK PAK1 MAP3K7IP1 MAP2K3 MAPK14 MAP2K4 BLK SRC YES1 LYN RALB DUSP8 DUSP16 c-fgr MAPK11 FYN CDC42 DUSP10 TRAF6 RIPK1 RAC1 MAP3K12 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY TNFRSF9 IL2 NFKB1 IL4 JUN MAPK8 IFNG MAPK14 IKBKB ATF2 NFKBIA MAP3K1 CHUK MAP3K5 RELA TRAF2 TNLG5A BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY WASL WASF1 ACTA1 CDC42 RAC1 PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY F2 NF1 GCK CREB1 INS SP1 CEBPA ACADVL CEBPB ALAS1 CEBPD SLC2A2 NR3C1 HEL111 TFRC UCP2 NKX2-1 ACADM FOXA1 PCK1 CPT1A HMGCS1 PKLR ABCC8 FOXF1 NR2A1 PDX1 HNF1A IGFBP1 CPT1C G6PC1 BDH1 ALB ALDOB TCF2 FOXA3 FOXA2 AFP PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL10 IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 AID PTPN6 IL13RA2 MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 ALOX15 THY1 SOCS3 SOCS1 SP1 CCL17 SOCS5 EGR2 HMGA1 PARP14 MAPK14 COL1A1 SHC1 CD40LG PIK3R1 CCL26 IL2RG BCL6 SELP MYB JAK3 JAK1 LTA MTOR RPS6KB1 PIK3CA CBL GRB2 BCL2L1 COL1A2 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY ROCK1 CTNND1 FGFR1 PIK3R1 GRIA2 DAGLA DCTN1 LRP5 GJA1 CDH2 CNR1 CDC42 CAMK2G RAC1 HEL-S-61 PTPN1 CTNNA1 JUP GAP43 PTPN11 FER PIP5K1C MYL2 DAGLB MAPRE1 PLCG1 AXIN1 PIK3CA MAPK8 ARHA CTNNB1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY EDN1 ASPH VHL HEL-S-133P EPO JUN CREB1 EP300 VEGFA COPS5 HIF1A PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY MAPK3 CRK FLT4 VEGFC PIK3CA VEGFD CREB1 GRB2 ITGA4 MAPK1 SOS1 ITGA2 ITGA1 MAPK14 COL1A1 ITGB1 SHC1 MAP2K4 PIK3R1 COL1A2 MAPK11 RPS6KA1 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CDK5R1 GSK3B CAPNS1 CAPNS2 PPP2CA APP CDK5 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD7 FZD1 FZD2 FZD5 FZD4 IGFBP4 RYK WNT3A WNT7B ATP6AP2 FZD9 KREMEN1 FZD8 WNT7A FZD10 LRP5 LRP6 WIF1 RSPO1 DKK1 ROR2 WNT1 WNT3 CTHRC1 BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY KCNA2 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS MAPK1 HRAS MAP2K2 ADCY1 RAF1 c-fgr PLCB1 KCNA1 PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 KLK6 UBE2L3 GRK5 PLD2 SNCA TH STUB1 MAPK1 HEL-117 CSNK2A1 SYK BAD BLK SRC YES1 LYN c-fgr FYN MAPK3 LCK FKBP1A PTK2B PPP2R5D PLCB2 BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY PDGFRA MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 PDGFA CSNK2A1 HRAS SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NR1i1 NCOA1 MED1 HDAC1 RXRA PRMT1 SMARCE1 SMARCD1 SUPT16H SMARCC1 SMARCA4 SMARCC2 CARM1 BAZ1B ARID1A NCOR1 CHAF1A TSC2 ACTL6A EP300 CREBBP BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY TNF IL1A SELP CSF3 ITGAM SELPLG SELL PECAM1 ICAM2 CXCL8 IFNG PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY ROCK1 TNF MMP9 THY1 IL6 BLK SRC PRKCZ YES1 CTGF LYN SELP ITGAM SELPLG c-fgr FYN PLAT RAP1A HMGB1 AGER APOB JAM2 JAM3 TLN1 PLAUR NFKB1 MYH2 LPA MST1R LCK MMP2 ARHA PLG BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY MAPK3 PRKAR1B PRKAR1A PRKACG IGF1 PIK3CA IGF1R KITLG IL3 KIT BCL2 MAPK1 ADCY1 BAD PIK3R1 BAX RPS6KA1 CSF2RB IL3RA BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY ITGB1 SELL SELE PECAM1 CD44 ITGA4 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY TGFA CCNB1 CCNA2 CCNE1 SP1 MYC BRCA2 CREBBP SKP2 MAP2K1 CDKN2A CDC2 LAMA4 CDK2 GSK3A CENPA ONECUT1 MMP2 FOXM1 RB1 AURKB CENPB CKS1B CCNB2 CCND1 NEK2 PLK1 NFATC3 FOS H2BC1 ETV5 CDC25B CENPF GAS1 CHEK2 EP300 CDK4 BIRC5 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY RB1 CDKN2A PIK3R1 PIK3CA MDM2 POLR1A POLR1C POLR1D TWIST1 RAC1 TBX2 MYC PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY EGFR PIK3R5 ROCK1 GNA13 PRKCA GNG2 ADRBK1 TBXA2R PTGDR PTGIR NHERF1 VCAM1 RAB11A GNB1 ARHGEF1 GNB5 PRKCE SYK MAPK14 BLK SRC ARRB2 PRKCZ YES1 LYN c-fgr FYN MAPK11 RAC1 GNA14 LCK GNA15 SELE GNA11 ARHA PRKCH EGF PRKCQ PLCB2 ARR3 PRKCB PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY PRL PIK3CD LRIG1 MAPK1 PIK3R3 WWOX PIK3R2 CBFA2T3 PRLR YAP1 ADAM17 DLG4 SHC1 NEDD4 PIK3R1 NCOR1 MDM2 FYN NRG1 NRG2 EREG BTC NRG3 MAPK3 NRG4 ERBB4 HBEGF WWP1 PIK3CA GRIN2B STAT5B GRB2 ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY PRKCA MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA CREB1 GRB2 RPS6KA5 MAPK1 SOS1 HRAS ADCY1 MAPK14 PIK3R1 RPS6KA1 RAC1 PRKCB PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PRKCA GNG2 RAB11A GNB1 PLD2 IL8RB PPP2R1A ARRB2 VASP LYN ELMO1 PPP2CA DOCK2 RAB5A c-fgr RAB7A PDPK1 CBL GNA14 GNA15 PLCB3 PLCB1 PLCB2 CXCL8 PRKCB BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY DCX DNCL1 NDEL1 LRP8 RELN CDK5 CSNK2A1 CDK5R1 PAFAH1B1 DCTN1 DCTN6 DNAH2 DNAH8 DCTN3 DNAH6 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY MAP2K1 MAPK3 EPOR PLCG1 EPO JUN MAPK8 STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 FOS RAF1 PTPN6 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY ADAM17 NRG3 PRKCA ERBB4 PSEN1 NRG2 PRKCB BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY ACTN1 ITGB1 TLN1 ACTN2 CAPNS1 ITGB3 EZR CAPNS2 SPTAN1 ACTA1 RAC1 ARHA PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY WASL JUN PIK3CD PIK3R3 PIK3R2 MAPK9 NCK1 BAD PIK3R1 MAP2K4 ARRB2 PRKCZ MAPK10 PARD6A FYN RAC1 PLCG1 PIK3CA PRKCI KIRREL1 MAPK8 CD2AP TJP1 NPHS1 GRB2 NPHS2 F2RL2 NCK2 TRPC6 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD2 THY1 CD3G CD3E CD3D PTPRC PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY KRT18 TNF MADD GAS2 CYCS BIRC2 BIRC3 MAP3K1 BAX CRADD TRADD TRAF2 ACTA1 PRF1 TNFRSF1A CASP2 RIPK1 PIDD1 CASP10 CASP6 SPTAN1 HEL113 APP BCL2 NUMA1 SATB1 DIABLO LMNB2 CASP9 CASP8 CFL2 CASP3 ARHGDIB CASP4 LMNA TFAP2A DFFB DFFA PARP1 APAF1 LIMK1 PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY WASL ARPC1B ACTR3 ACTR2 PAX6 PAK1 TIAM1 ARHGEF7 IQGAP3 HEL-S-15 MAPK1 PRKCE HEL-S-47e HES5 PAK4 MAP2K3 SEPTIN2 APC LIMK2 TNK2 MAP2K4 BRAF SRC MAP3K1 ARPC4 GSK3B YES1 ARPC5 CDC42BPA IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 CTNNA1 MAP2K6 RASGRF1 JUN EXOC7 MAPK9 MAPK14 PIK3R1 PRKCZ PARD6A RAC1 MYL2 MAPK3 MTOR RPS6KB1 PIK3CA CBL MAPK8 F2RL2 HRAS MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY EIF2S2 PRKCA SUI1 EIF2S1 ELAVL1 EIF2S3 KDR PLCG1 FLT4 VHL EIF2B1 PIK3CA VEGFA HRAS SHC1 PIK3R1 EIF2B5 EIF2B3 EIF2B2 FLT1 EIF1AX PRKCB HIF1A BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY PDPK1 NFKB1 FOXO4 PIK3CA GHR FOXO1 GH1 BAD IKBKB PIK3R1 CASP9 NFKBIA CHUK RELA PPP2CA FOXO3A TNFSF6 IKBKG BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB8A RAB11A ACTA1 RAB5A RAB2A RAB7A RAB1A RAB4A RAB6C RAB9A RAB27A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY ADCY1 FSHB FSHR CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY EGFR PSEN1 PSENEN SRC NCAN SDC3 CASK PTN MC4R POMC FYN APH1B AgRP CXCL8 PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY FZR1 TACC1 DLGAP5 TDRD7 CKAP5 TACC3 AURKAIP1 AJUBA RAN PAK1 GADD45A ARHGEF7 NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA BRCA1 CDC25B PPP2R5D HCTP4 OAZ1 BIRC5 PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY MMP9 KAT2A E2F3 BAX TAF12 TAF10 ACTL6A SUPT7L KAT5 CREBBP RUVBL2 RUVBL1 NBN EIF2S1 TFRC ENO1 NPM1 NCL BIRC5 CCNB1 PMAIP1 HEL-S-133P EIF4A1 BMI1 PEG10 UBTF PIM1 RCC1 MAX HEL-S-162eP ID2 MYC CAD NME2 HMGA1 PTMAP7 BCAT1 SHMT1 IREB2 RPL11 CDCA7 MTDH HSPD1 PRDX3 TERT MDIG CCND2 MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 SMAD4 FOSL1 LIN28B GPAM POLR3D NDUFAF2 SNAI1 TAF4B SERPINI1 PFKM EIF4G1 TRRAP TAF9 EP300 TK1 CDK4 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY EGFR MAP2K1 MAPK3 ERBB4 PIK3CA GRIP1 IL6 ERBB3 GRB2 IL6ST ERBB2 MAPK1 SOS1 IL6R HRAS SHC1 STAT3 CARM1 PIK3R1 RAF1 EP300 BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CCNH PTCH1 CCNB1 MNAT1 CDC2 CDC25B CDK7 SHH BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY MAP2K1 PRKCA MAPK3 F2 PLCG1 CALM1 MAPK8 AGTR2 GNA11 GRB2 CDK5 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAPK14 SHC1 STAT3 KNG1 STAT1 RAF1 FYN PRKCB PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY SFN CREB1 TH YWHAQ HEL-S-1 YWHAG HEL2 MAPK14 MAPKAPK3 TCF3 YWHAZ CDC25B HEL-S-102 TSC2 RAF1 MAPK11 MAPKAPK2 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY CYLD TNF MADD TNIK SQSTM1 NSMAF BIRC2 BIRC3 MAP2K3 ADAM17 IKBKB MAP4K2 MAP3K1 PRKCZ CHUK RELA TRADD TRAF2 SMPD1 MAP3K7 TNFRSF1A RIPK1 HEL-S-31 IKBKG NFKB1 PRKCI MAP3K7IP1 CASP8 NRK MAP3K5 TNFAIP3 TXN SMPD2 STAT1 BAG4 FADD RFFL MAP4K3 TRAF1 TNFRSF1B BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY PRKCA DLG4 PRKAR1B PPP3CA PRKAR1A GRIN1 PPP3CC PRKACG CALM1 GRIN2B PRKCB BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD2 CD8A THY1 CD3G CD3E CD3D PTPRC PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY SMAD2 TGFB1 PRNP SERPINC1 PLA2G2A TGFBR1 LCK APP CRIPTO TGFBR2 FGFR1 VEGFA GPC1 SLIT2 BLK SRC LAMA1 YES1 LYN c-fgr FYN NRG1 FGF2 FLT1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY MAP2K1 MAPK3 PLCG1 PIK3CA JUN MAPK8 NGFR GRB2 NGF SOS1 DPM2 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY GNG2 CCL11 GNB1 NRAS PIK3CD MAPK1 PIK3R3 CXCL9 PIK3R2 MAPKAP1 CXCL13 MAP2K3 CXCR3 MAPK14 MLST8 PIK3R1 RICTOR SRC CXCL10 KRAS CXCL11 PF4 MAPK11 MAP2K6 MAP2K1 MAPK3 PDPK1 GNAZ MTOR GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 RAF1 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY PRKCA SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 GRB2 SOS1 NGF DPM2 PRKCB HRAS BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM CHEK2 ATR CHEK1 PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY PRKCA PTPN11 MAPK3 PDPK1 PLCG1 PIK3CA CBL VEGFA CD2AP MAPK1 NCK1 PIK3R1 NRP1 SHC2 NRP2 VEGFB FLT1 PRKCB HIF1A BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY NFATC2 NFATC1 PRKAR1B NFKB1 PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 EGR2 MYC NFKBIA MAP3K1 CHUK RELA VIPR2 VIP PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY NRAS PIM1 MAPK1 SYK SHC1 IKBKB STAT3 PIK3R1 KRAS LYN CSF2 CSF2RA CCL2 MAP2K1 PTPN11 MAPK3 CISH GAB2 OSM IRF8 PRKACG PIK3CA STAT5B GRB2 SOS1 HRAS MAP2K2 FOS YWHAZ STAT1 RAF1 CSF2RB BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY KCNA2 ADCY1 KCNA3 ADRBK1 GNAS NR1C1 AP2A1 AP2M1 PLCB1 KCNA1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EGFR PRKCA NFKB1 PLCG1 ADAM12 EDNRA JUN AGTR2 EDNRB ARHA MYC HRAS EGF EDN1 FOS RELA PRKCB PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY NFATC2 ROCK1 FZD7 PPARG MAPK9 CAMK2A ARRB2 PRKCZ YES1 MAPK10 MAP3K7 CDC42 RAC1 NLK DVL1 MAPK8 DVL2 DVL3 FZD2 FLNA FZD5 MAP3K7IP1 SETDB1 CSNK1A1 ARHA DAAM1 ROR2 CTHRC1 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY MAP2K6 IL18 JUN MAPK8 CD3G CD3E CD3D IFNG TYK2 STAT4 MAPK14 CXCR3 CCR5 IL12RB1 IL18R1 ETV5 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY RB1 SKP2 CKS1B CDKN1B RBX1 NEDD8 UBE2M SKP1 TFDP1 CDK2 CCNE1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY TNF NFKB1 IKBKB NFKBIA CHUK RELA TRADD EP300 TNFRSF1A FADD CREBBP TRAF6 RIPK1 IKBKG TNFRSF1B PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY EGFR GULP1 EFNA1 PXN ACAP2 ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 ARRB2 AGTR1 ARF6 GNA14 GNA15 GNA11 EGF MET HGF ITGA2B CYTH2 KIF13B FBXO8 LHCGR USP6 ARAP2 IPCEF1 EPHA2 PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY TNF TGFB1 ABCA1 THRA NR1H2 NR1C1 NR1H4 RPS6KB1 NR1H3 NR1i1 NR1C2 NR1B3 NCOA1 NR1A2 RXRB MED1 NCOR2 BCL2 RXRA FAM120B RARA RARB PPARG RXRG PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY CYLD PRKCA TNF NFKB1 BIRC2 RAN ATM RIPK2 UBE2D3 BCL10 NOD2 IKBKB ERC1 NFKBIA CHUK TNFAIP3 RELA TNFRSF1A TRAF6 IKBKG PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY SQSTM1 JUN IKBKB ERC1 HEL-S-71 PIK3R1 IL1RN PRKCZ IRAK1 CHUK RELA TICAM2 IL1R1 IL1R2 IRAK3 MAP3K7 IRAK4 IL1B TRAF6 UBE2V1 IKBKG MYD88 MAP2K6 NFKB1 PIK3CA PRKCI MAPK8 MAP3K7IP1 IL1A BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY NPPA CORIN GNAS PIK3R1 NFKB1 NR3C1 PIK3CA RELA CALM1 ADRB2 ANXA1 PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF5 ARHGEF1 HEL-S-47e VAV2 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF11 ARHA VAV3 ARHGEF2 ARHGEF10 CDKN1B FARP1 ARHGEF12 ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 ARHGDIB MYO9B ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADCY1 CFTR PRKAR1B PRKAR1A NHERF1 PRKACG EZR ADRB2 BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY KHDRBS1 MAPK3 CDC2 MAPK1 HRAS PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY PLA2G7 KATNA1 DYNC1H1 NUDC DYNLT1 HEL-S-303 CDK5R2 CSNK2A1 HEL2 IQGAP1 CDC42 RAC1 DCX NDEL1 LRPAP1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA CDK5R1 PAFAH1B1 PPP2R5D BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK3 NFKB1 PIK3CA TFDP1 CDK2 PAK1 CCNE1 MAPK1 ARHA HRAS RB1 CDKN1A CDKN1B IKBKB CCND1 PIK3R1 NFKBIA CHUK RELA RAF1 CDK6 RAC1 CDK4 IKBKG PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY SPP1 MMP9 ROCK2 JUN PIP5K1A HEL-S-28 MAPK1 SYK PIK3R1 NFKBIA MAP3K1 ITGB3 CHUK RELA CDC42 RAC1 MAP3K14 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 CD44 PTK2B MMP2 ARHA VAV3 FOS PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY PERP SFN NR1i1 TOP2A NOTCH1 RRAD STXBP4 YAP1 DLX5 DLX6 TBXT HELLS GPX2 GSK3B TCF7L1 ADRM1 FBXW7 KRT5 MDM2 POU2F2 RUNX1 PPP2R5A FOSL2 BRCA2 NRG1 AXL FASN KRT14 RAB38 HES1 ADA CDKN2A CEBPD BDKRB2 WWP1 ATM ITCH MRE11A CCNB2 TP63 IL1A PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY EGFR CASR FMN1 ZYX PLCG1 CTNND1 AJUBA PIK3CA PIP5K1A ARHA CTNNB1 PIK3R1 SRC VASP FYN RAC1 JUP CTNNA1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY TGFB1 IL2 CCR1 IFNGR1 IFNGR2 CCL4 CCL3 IL4 CCR7 CCR4 CCR3 IL5 IFNG CXCR3 CCR5 CD40LG IL12RB1 IL18R1 CXCR4 CSF2 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY SOCS1 MAPK1 IFNG STAT3 CAMK2A PIK3R1 MAP3K1 CAMK2G IL1B CREBBP RAP1A JAK1 RAPGEF1 MAP2K1 PTPN11 CEBPB MAPK3 CRKL IFNGR1 MTOR PIK3CA CBL CAMK2D PIAS1 IRF1 IRF9 MAP3K11 STAT1 EP300 BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY IBSP ALPL COL4A2 ENPP1 SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY JAM3 PLAUR VCAM1 THY1 FGA KNG1 CD40LG SPON2 F10 HEL-S-62p ICAM3 GP1BA ITGAM ICAM4 F11R HEL-S-78p CYR61 PROC ICAM2 FCGR2A PLAT ITGAX TGFBI BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY TIMP3 CDK2 ATM GADD45A CCNE1 BCL2 RB1 CDKN1A CCND1 PCNA BAX MDM2 CDK4 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY SHC1 IL2RG RPS6KB1 IL4 GRB2 IRS1 JAK3 JAK1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A2 AAG1 EIF4A1 EIF4G1 EIF4E EIF3A BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY MAPK14 MAPK3 DUSP4 DUSP2 DUSP9 DUSP8 MAPK8 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY TREH PYGM PYGL LCT HEL-S-49 KHK BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY FOSL1 IFNB1 NFKB1 MAPK8 IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IRF9 IFNAR1 FOS RELA FOSL2 TRAF6 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL10 IFNA1 IFNB1 IL13 IL4 IL3 IL5 IFNG CD40 CD2 CD5 CD7 TLR7 CD33 ITGAX CSF2 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY GNAT2 RDH12 RGS9BP GRK7 CNGB3 GNB3 PDE6C RDH5 CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 ARR3 GNGT2 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY SMAD4 AXIN1 NLK NR1C2 DVL1 FZD1 CTBP1 HDAC1 FRAT1 MAP3K7IP1 BTRC CSNK2A1 MYC APC HNF1A CTNNB1 CCND1 GSK3B PPP2CA WIF1 MAP3K7 WNT1 CREBBP PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK1 GNA13 PRKCA GNG2 F2 GNB1 ROCK2 ARHGEF1 HEL-S-47e PIK3R1 VASP MYL2 ZYX GNAZ GNAI3 GNAI1 PIK3CA GNA14 GNA15 GNA11 SNX1 SNX2 F2RL2 TRPC6 F2R ARHA PKN1 GNAO1 PLCB3 PLCB1 PLCB2 PRKCB BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAR1B GNAS PRKAR1A PRKACG ADCY1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 MLXIPL PRKAG1 PPP2CA PRKAB1 BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL10 IL2 IL4 CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY SH3GL2 HGS AKT1S1 PXN NUMB WASL ARHGEF4 RIN2 EIF4EBP1 EGR1 RANBP9 PAK1 RANBP10 MUC20 MAPK1 PAK4 APC NCK1 MLST8 MAP2K4 SRC MAP3K1 CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN BAD SHC1 PIK3R1 PRKCZ PARD6A RAB5A RAC1 EIF4E PTPN1 ARF6 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PDPK1 PLCG1 MTOR SNAI1 PIK3CA PRKCI CBL MAPK8 GRB2 SOS1 F2RL2 NCK2 HRAS ARHA MAP2K2 CTNNB1 MET RAF1 INPPL1 RPTOR DEPTOR BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY NUTF2 KPNA2 RAN NUP214 RANBP2 NUP210 RCC1 NUP62 NUP153 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SFN SLC2A4 MAPKAP1 HEL2 AKT3 BAD MLST8 KPNA1 RICTOR TBC1D4 SRC GSK3B CHUK FOXO3A PDPK1 MTOR FOXO4 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 CDKN1A YWHAG CDKN1B PRKDC CASP9 MAP3K5 YWHAZ RAF1 BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY MAPK14 CD36 FOS CASP3 JUN FYN THBS1 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY EGFR MAP2K1 PRKCA MAPK3 PLCG1 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS EGF SHC1 STAT3 MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 PRKCB JAK1 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY GTF3C1 GTF3C3 SSB HEL-S-76p TBP GTF3C5 PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY GNG2 GNB1 CREB1 MAPK1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG MAP2K1 MAPK3 GNAZ PLCG1 GNAI3 GNAI1 PIK3CA HRAS MAP2K2 GNAO1 FOS PLCB3 RAF1 PLCB1 PLCB2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY HDAC7 SIRT1 KAT2B EGR1 NCOA1 JUN HDAC1 RXRA SMARCE1 CEBPA SMARCC1 MAPK14 CARM1 MAP2K4 SRC GSK3B REL MDM2 KAT5 CREBBP TMPRSS2 MAP2K6 KLK3 HOXB13 NR2C2 ZMIZ2 TRIM24 NR3C1 KAT7 SRY SPDEF FOXO1 POU2F1 RXRB MAPK8 NR0B1 SENP1 APPBP2 PDE9A RXRG PKN1 EP300 GATA2 RCHY1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY ROCK1 GNA13 GNG2 MYL2 F2 GNA14 GNB1 ROCK2 GNA15 GNA11 F2RL2 F2RL3 ARHA PLCB2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY SNAI1 HDAC1 HEL-S-130P HEL-S-162eP MBD3 GREB1 TUBA4A TUBA1A TUBA2 MTA3 HSPB2-C11orf52 HEL-S-102 SNAI2 HEL-S-87p BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY ITGB1 SELP ITGAM SELL SELE PECAM1 CD44 ITGA4 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY ACTN1 ROCK1 CAPNS1 CAPNS2 JUN MAPK1 SHC1 ACTA1 FYN RAP1A RAPGEF1 MAP2K1 MAPK3 CRKL ZYX TLN1 ACTN2 MAPK8 GRB2 SOS1 HRAS ARHA MAP2K2 ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 BCR BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAFK PRKCA NFE2L2 HMOX1 JUN MAPK8 CREB1 MAPK1 MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFG PRKCB MAFF BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ZAP70 PRKAR1B PRKAR1A PRKACG LCK CD3G CD3E CD3D PTPRC ADCY1 CSK HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CREBBP BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY ROCK1 PRKCA GNA13 F2 PIK3CA ARHGEF1 PTK2B F2RL3 F2R ARHA ADCY1 PIK3R1 PPP1R12B PLCB1 MAP3K7 PRKCB BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY ABCA1 FABP6 LDLR NR0B2 NR1H4 NR1H3 RXRA BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY MDC1 ABRAXAS1 RNF8 SMC3 UIMC1 TP53BP1 SMC1A RFWD2 TERF2 HEL-S-71 RBBP8 H2AX MDM2 BLM KAT5 NBN ATM CTBP1 TOP3A HEL-S-1 MRE11A BRCA1 RAD50 FANCD2 TRIM28 RAD17 CHEK2 RAD9A BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY RBL1 JUN NCOR2 HRAS HDAC5 CSF1R HDAC2 FOS CSF1 ETV3 E2F4 ETS2 SIN3B SIN3A BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY CTLA4 PTPN11 ICOS ICOSLG IL2 PIK3CA LCK CD3G GRB2 CD3E CD3D PIK3R1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 ITK PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY HEL-S-42 INSR ASIP LNPEP SFN PPP1R3A SLC2A4 PRKCI GYS1 TRIP10 STX4A INS VAMP2 YWHAQ HEL-S-1 STXBP4 YWHAG HEL2 PPP1CC TBC1D4 GSK3B PRKCZ YWHAZ BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY TIMP3 MMP9 MMP14 TIMP1 MMP2 RECK HRAS TIMP4 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY SMAD2 CTDSP1 SMAD4 CTDSP2 KPNA2 CTDSPL MAPK3 MAP3K1 UBE2I NUP214 MAPK1 NUP153 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY BMP4 BMP2 BMPR1A APC GSK3B MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 TGFBR1 DVL1 TGFBR2 FZD1 TGFBR3 HNF1A CTNNB1 BMP10 ATF2 BMPR2 GATA4 NPPB DKFZp781O1323 NKX2-5 ACVR1 SMAD1 MEF2C WNT1 RFC1 NOG BMP7 BMP5 BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY NFATC2 MAP2K6 NFATC1 CABIN1 MAPK7 INSR PPP3CA MYOD1 PPP3CC AVP CAMK1 IGF1 PIK3CA CAMK1G IGF1R CALM1 MAPK14 HDAC5 PIK3R1 BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY SIRT1 TNF SUMO1 SP100 PAX3 PRAM1 RARA HRAS RB1 PML FAS TNFRSF1A CREBBP TNFSF6 TNFRSF1B PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD4 BMPR2 DKFZp781O1323 ACVR1 FKBP1A SMAD1 AMHR2 TLX2 SMAD9 AMH BMP7 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY EIF4A2 PRKCA AAG1 MAPK3 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 GHR EIF4G1 MAPK1 PABPC1 PDK2 MAPK14 PIK3R1 IRS1 EIF4E PRKCB PTEN PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY PIK3R5 ZAP70 NRAS PIK3CD PIK3R3 PIK3R2 SYK ARF1 DAPP1 BLNK PIK3R1 CYTH1 BLK SRC PLEKHA1 KRAS YES1 PLEKHA2 LYN BTK SGK1 LAT c-fgr ARF5 FYN PLCG2 FOXO3A RAC1 RAP1A ITK PTEN ARF6 PDPK1 PLCG1 PIK3CA LCK HRAS ARHA CYTH2 INPPL1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY ACO2 SDHA CS FH SUCLA2 HEL-S-32 OGDH PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PERP PMAIP1 NR1i1 GDF15 GADD45A SP1 EGR2 PML IKBKB GPX2 TP53I3 FAS CHUK BAX MDM2 DICER1 ADA SMARCD3 BBC3 CDKN2A OGG1 CABL1 ITGB4 NOC2L EVPL CLCA2 WWP1 FLOT2 NQO1 TFAP2C DST YWHAQ AEN SSRP1 ITCH DHRS3 SHH SERPINB5 TRAF4 MFGE8 CDKN1A FDXR TP63 PLK1 S100A2 EP300 BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CCNB1 SMURF2 CDC2 SMURF1 SFN CDK2 CDK5 CDK7 CDK8 CCNB2 CDK3 TRIM25 CDK6 CDK4 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY SNAP25 CHRM1 STX1A CHRNA1 VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY FZR1 CENPU C13orf34 KIF20A CCNB1 TUBG1 CENPE STAG2 PRC1 NUDC GORASP1 KIZ SPC24 PAK1 TPT1 ROCK2 PPP2R1A PPP2CA CDC2 FBXW11 RAB1A ECT2 ARHA AURKA SGOL1 PLK1 ERCC6L CDC25B BUB1B KNTC2 WEE1 CDC14B CDC20 GOLGA2 HEL-S-80p FBXO5 INCENP HCTP4 CLSPN NINL PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY SIRT1 CCNA2 MYOD1 TFDP1 PAX3 CCNE1 CEBPA RBBP4 E2F2 E2F3 E2F4 TBP MAPK11 CREBBP CSF2 SKP2 CEBPB CDKN2A CEBPD CDK2 ELF1 CCND1 SPI1 SUV39H1 JUN AATF UBTF HDAC1 BRD2 SFTPD RUNX2 PPARG RBP2 ATF7 MAPK9 HDAC3 BGLAP MAPK14 SMARCA4 GSC CBX4 PPP2R3B TAF1 PPP2CA MDM2 CCND2 CDK6 CTBP1 RB1 CDKN1A CDKN1B ATF2 MET CCND3 RAF1 EP300 MEF2C CDK4 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 MYT1 CDC25B WEE1 ATM CHEK1 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY SFN EGR1 NRAS CREB1 NGF HEL2 BAD SHC1 CAMK2A PIK3R1 CAMK4 SRC KRAS GSK3B AGAP2 NTRK1 TRPC3 TRPV1 FOXO3A PDPK1 PLCG1 PIK3CA YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY PDGFRA PIK3R1 WASL PIK3CA PAK1 CDC42 RAC1 ARHA BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY HDAC5 PPP3CA CAMK4 PPP3CC NR1C1 CAMK1 SLC2A4 CAMK1G CALM1 ESRRA PPARGC1A PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY PTPN11 PXN CRKL PDPK1 CRK RPS6KB1 PIK3CA IGF1R GRB2 SOS1 NCK2 HRAS HEL2 BAD SHC1 PIK3R1 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY FAS PRF1 CD3G HLA-A CD3E TNFSF6 B2M CD3D BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY PDGFRA EGFR MAP2K1 MAPK3 GNAS IGF1R NGFR GRB2 NGF RPS6KA5 MAPK1 SOS1 DPM2 MYC HRAS MAP2K2 ITGB1 SHC1 STAT3 PPP2CA RAF1 RPS6KA1 BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY GPD2 UQCRC1 SDHA SDHC SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 ZNF183 BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY MAPK14 FBL GPT EIF4E NCL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY PRKCA MAPK3 CDC2 KAT2B NR1i1 NR1B3 NCOA1 RXRB MAPK8 RBP1 HDAC1 NCOR2 RXRA RARA MAPK1 CDK7 RARB CCNH RXRG HDAC3 MAPK14 MNAT1 EP300 CREBBP BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC PLCG1 CALM1 MARCKS SP1 SP3 CDKN1A NFATC4 NFATC3 PRKCB BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY TBXA2R PTGIR PTGER1 PTGER4 CYP2J2 KPG_011 PTGFR PTGIS EPHX2 PTGER2 EPHX1 PTGER3 PTGS2 PTGS1 ALOX5 ALOX5AP PTGES PLCB1 PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY EGFR IGF2 GNA13 ADAM10 HGS ZBTB33 MEP1B GDNF RIN2 CTNND1 TIAM1 SRC IQGAP1 RAB5A CDH2 RAB7A FYN CDC42 RAC1 CREBBP PTPN1 CTNNA1 JUP ARF6 CABL1 IGF1R SNX1 HRAS CTNNB1 EGF MET CASP3 RET ROBO1 SLIT1 NTRK2 MMP7 BDNF PTPN6 MMP3 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY ADAM17 PSEN1 RBPJ FURIN NOTCH1 PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY EGFR ACTN1 ROCK1 EFNA1 CYFIP2 CTNND1 NCKAP1 AQP5 AQP3 LPP LIMA1 MYO6 MGAT3 PLEKHA7 CAMSAP3 KIFC3 NCK1 VASP EXOC4 EXOC3 AFDN CTNNA1 ARF6 PIP5K1C MYL2 ZYX NECTIN2 IGF1R STX4A ARHA CTNNB1 EGF MET HEL114 HGF EPHA2 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY HDAC9 PIAS2 HDAC6 SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IL2 IFNGR1 IFNGR2 IL18 IL4 IL2RA IFNG CD40 CD40LG IL12RB1 NR1i2 IL18R1 IL12B IL12A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY NFKB1 MAPK8 MAPK14 CHUK TWEAK RELA TNFSF13 TRAF2 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TRAF6 TNFSF12-TNFSF13 MAP3K14 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 BIRC2 CASP6 BIRC3 LMNB2 CASP9 CASP8 CASP3 ARHGDIB CASP4 PRF1 LMNA DFFB CASP2 DFFA PARP1 APAF1 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY TNF IFNA1 IFNB1 JUN IL6 MAP2K3 MAPK14 IKBKB NFKBIA IL1RN MAP3K1 IRAK1 CHUK RELA IL1R1 IRAK3 MAP3K7 IL1B TRAF6 IRAK2 MYD88 MAP3K14 MAP2K6 TGFB1 NFKB1 MAPK8 MAP3K7IP1 IL1A BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY PDGFRA SPHK1 PRKCA S1PR1 ITGAV MAPK3 PIK3CA MAPK1 PDGFA ARHA ADCY1 PIK3R1 ITGB3 SMPD2 SMPD1 PLCB1 RAC1 SPHKAP PRKCB BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY PSMB6 CD74 TAP2 HLA-DRB5 HLA-DRB4 TAP1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-A B2M BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY LDLR MBTPS1 MBTPS2 SREBF2 LIMA1 HMGCS1 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY PIK3CD MAPK1 TNFRSF10C PIK3R3 PIK3R2 TNFRSF10B TNFRSF10A TNFRSF10D IKBKB PIK3R1 MAP2K4 MAP3K1 CHUK TRADD TRAF2 SMPD1 RIPK1 IKBKG MAPK3 CASP10 PIK3CA TNFSF10 DAP3 MAPK8 CASP8 FADD BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY TNF NFKB1 MAP3K7IP1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA IL1A IL1R1 TRADD TNFRSF1A FADD MAP3K7 TRAF6 RIPK1 IKBKG MYD88 TNFRSF1B MAP3K14 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY GTF2A1 KAT2B NCOA1 TBP NCOR2 RXRA RARA BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGEF5 ROCK1 MYL2 TLN1 ARHGAP5 ARHGAP4 ARHGEF1 OPHN1 PIP5K1A ARHGEF11 ARHA ARHGAP1 HEL114 STM7 PFN1 BAIAP2 PPP1R12B LIMK1 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EGFR HGS TF EGF EEA1 TFRC RAB5A BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY EGFR MAP2K1 MAPK3 CBL GRB2 MAPK1 SOS1 HRAS EGF SHC1 SPRY4 RAF1 PTPRB SPRY2 SPRY1 PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY GNA13 S1PR1 ITGAV MAPK3 GNAZ GNAI3 GNAI1 GNA14 VEGFA GNA15 GNA11 MAPK1 ARHA AKT3 GNAO1 SRC ITGB3 CXCR4 S1PR3 RAC1 FLT1 S1PR2 BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY MAP2K1 MAPK3 CRKL PIK3CA JUN MAPK8 STAT5B GRB2 SOS1 MYC HRAS BAD MAP2K4 PIK3R1 MAP3K1 FOS STAT1 RAF1 BCR BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY MAP2K1 PRKCA MYL2 MAPK3 GNAS CCL11 ROCK2 CCR3 MAPK1 ARHA HRAS PPP1R12B RAF1 PLCB1 PRKCB LIMK1 PIK3C2G BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDT1 MCM7 ORC6 CDC6 ORC3 ORC2 MCM5 MCM6 MCM2 CDK2 KITLG CCNE1 MCM3 CDKN1B ORC1L BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY MAP2K1 MAPK3 NSMAF NFKB1 AIFM1 MAPK8 BCL2 MAPK1 BAD MAP2K4 MAP3K1 CASP8 BAX RELA TRADD TRAF2 RAF1 SMPD1 TNFRSF1A FADD RIPK1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY ASAP2 ARFGEF1 ARFGEF2 COPA GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH1 ARAP1 CYTH2 ARAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY TYK2 IFNAR1 STAT2 IFNA1 IFNB1 STAT1 IFNAR2 IRF9 JAK1 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY TNF SIRT1 KAT2B RANBP2 HDAC9 HDAC6 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 UBE2I SUMO1 RAN NCOR2 HDAC1 MAX PPARG HDAC3 HDAC10 HDAC11 STAT3 CHD4 HDAC5 NFKBIA CHD3 MBD3L2 SMG5 RELA SIRT4 SIN3B SIRT5 SIN3A SIRT6 SIRT7 SIRT2 SIRT3 SAP30 ZFPM1 FKBP3 HDAC8 GATA1 SAP18 RBBP7 NFKB1 MTA2 SMURF1 MBD2 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 YY1 EP300 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY NFATC2 NFATC1 PPP3CA PPP3CC CALM1 JUN MAPK1 SYK SHC1 PIK3R1 MAP2K4 NFATC4 MAP3K1 LYN BTK MAP2K1 MAPK3 PLCG1 PIK3CA MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY DOCK1 SQSTM1 DYNLT1 TIAM1 NRAS NGFR NGF MAPK1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK CCND1 RASGRF1 SHC1 STAT3 PIK3R1 PRKCZ ELMO1 RAC1 MAP2K1 PTPN11 GAB2 MAPK3 CRKL PLCG1 PIK3CA PRKCI MCF2L GRB2 SOS1 MATK HRAS FRS2 ARHA FRS3 FAIM SHC3 MAGED1 NTF4 NTF3 SH2B1 NTRK3 ARHG RIT1 RIT2 NTRK2 BDNF PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ZFP36 EGFR KSR1 MYL11 SH2D2A MAPK7 WASL WASF2 MAP2K5 CYFIP2 ARPC1B MAP3K2 NCKAP1 ACTR3 EGR1 PPP5C ACTR2 CREB1 NRAS RPS6KA5 MAPK1 MAPKAP1 ATF1 MLST8 MAP2K4 RICTOR BRAF SRC MAP3K1 ARPC4 KRAS ARPC5 IQGAP1 BAIAP2 ARPC2 ARPC3 VAV2 CDC42 HEL-S-34 FOS PRKCA RALA SFN RIN1 PLD2 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 HEL2 BAD STAT3 PIK3R1 PPP2R2A PPP2R1A PRKCZ PPP2CA RAB5A RAC1 RPS6 MAP2K1 MAPK3 PDPK1 MTOR PIK3CA MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 F2RL2 HRAS BCL2L1 MAP2K2 YWHAG EGF ATF2 YWHAZ RAF1 STAT1 SMAD1 USP6NL MEF2C ARF4 BRK1 RPS6KA4 RPS6KA3 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY EGFR PRKCA TNKS IGF1R XRCC5 TERF1 TEP1 BCL2 MYC RB1 KRAS PPP2CA TERT BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY ATF2 NFKB1 KAT2B IRF4 RELA JUN IRF3 CREBBP IRF2 IRF1 IRF7 HMGB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAPK7 MAP2K5 MAP3K2 PAK1 CREB1 RPS6KA5 MAPK1 RPS6KA2 MAP3K8 MAP3K6 MAP2K3 CEBPA MAPK13 MAPK6 MAP4K2 MAPK4 MAP2K4 MAPK12 MAP3K1 RPS6KB2 CHUK MAP3K10 MAP3K13 TRADD TRAF2 MAPK11 RIPK1 MAP3K12 MAP3K14 MAP2K6 FOS RPS6KA1 JUN SP1 MAX MYC MAPK9 MAPK14 IKBKB SHC1 NFKBIA MAPK10 RELA MAP3K7 RAC1 HEL-S-31 MAP2K1 MAPK3 TGFB1 NFKB1 RPS6KB1 TGFBR1 MAPK8 GRB2 HRAS MAP2K2 MAP3K11 ATF2 MAPKAPK3 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K3 RPS6KA4 RPS6KA3 MAP4K1 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY SIRT1 CCNB1 RALA RBL2 KAT2B SFN RAN GADD45A MAPK9 HEL2 IKBKB CHUK MAPK10 BCL6 RALB ZFAND5 SGK1 BCL2L11 CSNK1G3 CSNK1D FOXO3A FBXO32 CREBBP CSNK1G2 TNFSF6 CSNK1G1 SKP2 FOXO4 CDK2 FOXO1 MAPK8 YWHAQ CSNK1E HEL-S-1 CSNK1A1 YWHAG CDKN1B CTNNB1 G6PC1 PLK1 YWHAZ EP300 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY LCP2 CRKL CRK JUN MAPK8 MAP3K8 MAP2K4 MAP3K1 LAT MAP3K7 MAP4K1 PRKCB GRAP2 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY TREX1 NBN RAD51 ATM FANCA MRE11A HUS1 FANCC FANCE FANCG BRCA1 FANCF RAD50 FANCD2 RAD17 CHEK2 RAD1 BRCA2 ATR CHEK1 RAD9A PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGFR WASL PAK1 NRAS PIK3CD MAPK1 PIK3R3 PIK3R2 NCK1 SHC1 STAT3 PIK3R1 SRC KRAS PTPN1 PTPN11 PIP5K1C MAPK3 TLN1 PLCG1 GNAI3 GNAI1 PIK3CA GRB2 SOS1 NCK2 HRAS EGF STAT1 PTPN6 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY TNF CASP8 BIRC3 TRADD TRAF2 BAG4 FADD TNFRSF1A RIPK1 TNFRSF1B BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY MAP2K6 PGLYRP1 NFKB1 TLR3 NR1C1 JUN MAPK8 MAP3K7IP1 EIF2AK2 MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA TLR7 MAP3K1 FOS CHUK RELA MAP3K7 TRAF6 IKBKG MYD88 MAP3K14 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY MAP2K2 KCNA2 ADCY1 MAP2K1 KCNA3 ADRBK1 MAPK3 GNAS RAF1 PLCB1 MAPK1 KCNA1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY EIF2S2 EIF2S1 PDPK1 EIF2S3 MTOR RPS6KB1 EIF4EBP1 IGF1 PIK3CA IGF1R PDK2 PIK3R1 GSK3B PPP2CA EIF2B5 INPPL1 EIF4E PTEN BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY MAP2K1 MAPK3 KLRC2 KLRC3 KLRC4 IL18 PIK3CA KLRD1 PAK1 KLRC1 PTK2B SYK ITGB1 PIK3R1 LAT VAV1 HLA-A RAC1 PTPN6 B2M BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY PAK1 JUN RIPK2 MAP2K4 MAP3K1 FAS MAP3K7 TNFSF6 CASP10 CASP6 SPTAN1 FAF1 MAPK8 PTPN13 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB LMNA FADD DFFB DFFA PARP1 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA3 UBQLN1 GABARAP GPHN GABRA2 GABRA6 GABRA5 GABRA4 BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY CYP26A1 CYP2C9 CYP24A1 ABCA1 CYP1A2 CYP2E1 NR0B2 ABCG1 NR1H4 NR1H3 NR1C2 NR1i1 NR1B3 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 NR1I3 CYP4A22 CYP3A4 CYP27B1 CYP2B6 ABCC3 ABCG5 ABCB1 ABCC2 ABCB4 CYP4A11 CYP4B1 ABCB11 CYP8B1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 RBPJ KDM1A MAML2 MAML1 GATA6 ASCL1 NCOA1 HDAC1 HEY2 NCOR2 SPEN HES6 NOTCH1 GAA RUNX2 RCAN1 ID1 PTF1A BGLAP NEUROG3 STAT3 RBBP8 NCOR1 MYB CREBBP HES1 GATA1 KDR GHR CTBP1 CAMK2D RB1 CDKN1B GATA4 TCF3 YY1 EP300 TWIST1 PARP1 HIF1A BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A2 AAG1 PDPK1 MTOR RPS6KB1 EIF4EBP1 PIK3CA EIF4A1 EIF4G1 EIF3A PDK2 TSC1 PIK3R1 RHEB PPP2CA TSC2 EIF4E PTEN BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY ZAP70 HLA-DRB5 HLA-DRB4 LCK HLA-DRA FYN HLA-DRB3 CD3G HLA-DRB1 CD3E CD3D PTPRC PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 THY1 VEGFA COL1A1 VTN ITGB3 EDIL3 L1CAM SDC1 F11R CD47 FBN1 PECAM1 HMGB1 SPHK1 ITGAV PLAUR KDR LAMA4 LAMC1 TGFBR2 IBSP FGA SDC4 LAMB1 TNC COL1A2 ITGA2B HEL-S-78p THBS1 CYR61 TGFBI PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY RASGRF1 DOCK1 KALRN TIAM1 ARHGEF7 HEL-S-47e ELMO1 DOCK2 DOCK6 VAV2 ARHGAP17 PREX2 RAC1 PREX1 CHN1 RALBP1 SPATA13 TRIO ARHGEF25 SOS1 VAV3 ARHGEF2 ARHGAP1 DEF6 VAV1 BCR RASGRF2 PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY LY96 TICAM1 TIRAP TLR3 TLR1 SFTPA1 CD14 S100A9 TLR4 S100A8 ARHA VCAN IKBKB CHUK IRAK1 HSPD1 IRAK4 IRAK2 IKBKG MYD88 HMGB1 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY TNF BIRC2 BIRC3 NFKBIA MAP3K1 FAS CHUK RELA CRADD TRADD MDM2 TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 PSEN1 NFKB1 CASP6 SPTAN1 MAPK8 PSEN2 BCL2 ACTG1 CDK11A RB1 NUMA1 LMNB2 PRKDC CASP9 CASP8 MAP3K5 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 TRAF1 APAF1 TNFRSF1B BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PRKCA NFKBIA NFKB1 RELA PLCB1 PRKCB BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY NBN RAD51 NFKB1 ATM JUN MAPK8 TP73 GADD45A MRE11A CDKN1A NFKBIA RBBP8 BRCA1 RAD50 RELA MDM2 CHEK2 CHEK1 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY HDAC7 GNG2 ADRBK1 UBE2I SUMO1 RAN GNB1 NCOR2 RANBP2 HDAC3 HDAC9 HEL2 HDAC10 HDAC11 HDAC6 HDAC5 CAMK4 BCL6 GATA1 NR3C1 TUBA1B HEL-S-1 RFXANK TUBB2A BCOR ANKRA2 MEF2C GATA2 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY ITGAM SELL SELE PECAM1 CD44 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY MAP2K2 MAP2K1 CDK5R1 MAPK3 EGR1 RAF1 NGFR CDK5 MAPK1 NGF DPM2 HRAS PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY ACTN1 PXN CKAP5 TACC3 JUN CREB1 ARHGEF7 HEL-S-28 RICTOR GSK3B IQGAP1 CDC42 RAC1 RUVBL2 RUVBL1 ZYX SNAI1 NCK2 CTNNB1 AURKA CCND1 ILKAP PPP1R14A GIT2 PPP1R14B TNS1 PPP1R14C PARVA ARHG PARVB PARVG NACA CDC37 ELMO2 PARP1 LIMS1 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GOSR2 USO1 CLTA AP2A1 AP2M1 PLD2 COPA PIP5K1A GBF1 CLTB ASAP1 ARF1 CYTH2 RAC1 KDELR1 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY SPHK1 GNA13 S1PR1 SPHK2 SGPP1 GNAZ SGPL1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 GNA15 GNA11 GNAO1 ABCC1 S1PR3 S1PR2 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY ADRBK1 LRPAP1 PIK3CA STIL DHH HHIP PTCH2 IHH PTHLH SMO SHH BOC CDON PTCH1 PIK3R1 ARRB2 GAS1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY TGFB1 IGF1 CCL3 EPO KITLG IL3 IL6 IL9 IL11 FLT3 IL1A CSF3 CSF2 BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY RB1 CHAF1B CCND1 BTG1 CHAF1A BTG2 PRMT1 NGF PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY PIK3R5 ROCK1 EFNA1 EFNA5 BLK SRC EPHA7 YES1 EPHA8 LYN EFNA3 EFNA2 EPHA1 EPHA4 c-fgr EPHA3 FYN VAV2 CRKL CRK PLCG1 CBL LCK CDK5 ARHA VAV3 ARHGEF15 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY SMARCA4 NEDD8 NR0B2 HEL-S-62p UBE2M NCOA1 NR0B1 NR3A2 UBA3 DDX54 ZNF14 SMARCE1 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY TYK2 MAPK3 STAT3 MTOR MAPK1 JAK3 JAK1 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY TNF BCL2 CASP9 MAPKAPK3 HSPB2-C11orf52 FAS IL1A CASP3 HEL-S-102 ACTA1 MAPKAPK2 TNFSF6 APAF1 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY CELA3B GRN SLPI ELA2B CELA1 ELANE CXCL8 CELA2A PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY SIRT1 MYOD1 KAT2B ACSS2 H4C9 FOXO4 FHL2 FOXO1 HOXA10 MEF2D HIST1H1E ACSS1 TUBA1B PPARGC1A TUBB2A CDKN1A BAX EP300 SIRT7 SIRT2 FOXO3A CREBBP SIRT3 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY PRKCA ZAP70 CD8A NRAS CD3G CD3E CD3D PRKCE MAP3K8 BCL10 SHC1 IKBKB KRAS CHUK LAT PRF1 FYN HLA-A TRAF6 RAP1A IKBKG B2M GRAP2 MAP3K14 LCP2 PDPK1 PLCG1 CBL LCK PAG1 GRB2 CD8B1 SOS1 STIM1 HRAS PTPRC TRPV6 ORAI1 CARD11 CSK PRKCQ CD80 VAV1 PTPN6 PRKCB BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY EGFR MAPK3 PDPK1 PIK3CA HEL-S-28 GRB2 MAPK1 SOS1 PDK2 CDKN1B ITGB1 SHC1 PIK3R1 FOXO3A TNFSF6 PTEN PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY PKN1 MAP2K6 MAP2K3 MAPK13 EEF2K CCND1 pk MAPK12 SNTA1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY NFATC2 HMOX1 NFATC1 CCNA2 MMP9 JUN IL6 SP1 LIF BGLAP GJA1 FOSL2 CCL2 FOSL1 CDKN2A PLAUR ITGB4 MMP2 CCND1 TXLNG NFATC3 LAMA3 THBD JUNB COL1A2 JUND USF2 EP300 DCN MGP IVL ATF4 CXCL8 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY UROD UROS HMBS GATA1 ALAS1 CPOX HBB HBA2 ERAF ALAS2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI PIK3CA IL7 LCK IL7R BCL2 STAT5B PTK2B PIK3R1 EP300 FYN CREBBP JAK3 JAK1 BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A2 F2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 APP F9 PLG F11 PLAT BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF2 CSTF2 CSTF1 PAPOLA BCL2L2-PABPN1 CPSF4 CPSF1 PABPN1 CPSF3 CSTF3 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY SPHK2 CD8A IL18 IL4 CD3G CD3E CD3D IFNG MAP2K3 IL12B IL12A MAP2K6 CCL4 CCL3 CD8B1 TYK2 STAT4 CCR5 IL12RB1 IL18R1 FOS PPP3CA NOS2 SOCS1 RIPK2 MAPK14 STAT3 IL18RAP IL2RG RELB RELA PPP3R1 IL1R1 HLX TBX21 RAB7A GADD45B GZMA IL1B GADD45G HLA-A NFKB2 B2M TNFSF6 IL2 NFKB1 MTOR LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY NFATC2 PRKCA NFATC1 ZAP70 PPP3CA PPP3CC CALM1 JUN CD3G CD3E CD3D SHC1 PIK3R1 MAP2K4 NFATC4 NFKBIA MAP3K1 RELA LAT FYN RAC1 MAP2K1 MAPK3 NFKB1 PLCG1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY CD79A SMAD4 TGFB1 CDKN2A MTOR RPS6KB1 PIK3CA TGFBR1 TGFBR2 TGFBR3 MYC CDKN1B PIK3R1 DKFZp781O1323 PPP2CA MDM2 SMAD1 CTCF PTEN CD79B BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PKN1 GNA13 ROCK1 PRKCA PPP1R12B ARHGAP5 ARHGEF1 PLCB1 PRKCB PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY RALBP1 ITSN2 SPATA13 DOCK9 ITSN1 FGD1 ARHGEF25 DOCK10 DOCK11 PLCG1 ARHGEF9 ARHGEF7 MCF2L HEL-S-47e VAV3 APC FARP2 ARHGAP1 DOCK6 VAV2 ARHGAP17 CDC42 PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY ROCK1 MAPK3 CCNA2 EGR1 RABGGTB RABGGTA CDK2 PTP4A1 PTP4A2 PTP4A3 CCNE1 ATF5 MAPK1 TUBA1B ARHA CDKN1A ITGA1 ITGB1 SRC RAC1 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY FGA F2 PLG HEL-S-78p CPB2 SERPINB2 PLAT F2R F13A1 PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY DOCK1 WASL PAK1 MAPK1 NCK1 CAMK2A PIK3R1 SRC YES1 AGAP2 ELMO1 FYN CDC42 RAC1 MAP2K1 TRIO MAPK3 PLCG1 PIK3CA MAP1B ARHA HEL-S-36 MAP2K2 NTN1 UNC5A UNC5B DCC PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY PXN MAPK1 MAP2K4 MAP3K1 CHUK BTK LAT IKBKG SPHK1 LCP2 S1PR1 PTPN13 FOS PRKCB NFATC2 PLD2 JUN SYK IKBKB SHC1 PIK3R1 RELA LYN FYN ITK MAP2K1 PTPN11 FER GAB2 MAPK3 NFKB1 PLCG1 PIK3CA CBL MAPK8 FCER1A FCER1G GRB2 MS4A2 SOS1 HRAS MAP2K2 WIPF1 LAT2 DOK1 HCLS1 RAF1 PLPP1 PLA2G1B VAV1 FCGR2B BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 MASP2 MASP1 MBL2 C1QC HEL-S-62p CFD C1QB C1QA C1S BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET CREBBP DFFA APEX1 HMGB2 BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 MAN1A2 FUT9 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY TNIK MMP9 APC TBXT CAMK4 TCF7L1 ZCCHC12 CHD8 CBY1 RUVBL2 MED12 SALL4 PITX2 MYOG CDKN2A TLE4 TLE2 CTNNBIP1 KRT1 AXIN2 TLE5 DKK4 FGF7A MDFIC DVL3 TBL1XR1 LEF1 CACNA1G IGF2BP1 COX2 TBL1X TCF7L2 CCND1 CDX4 CDX1 KCNIP4 KLF4 SKP1 BCL9 SP5 TCF4 NEUROG1 CYR61 DKK1 MYF5 INCENP SFN JUN HDAC1 ID2 MYC HEL2 SMARCA4 TERT SNAI2 CCND2 CTBP1 YWHAQ HEL-S-1 MMP2 YWHAG VCAN CTNNB1 TRRAP HDAC2 YWHAZ EP300 CXCL8 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY MAP2K1 PRKCA MAPK3 INSR PLCG1 SLC2A4 PIK3CA GHR GH1 STAT5B SOCS1 GRB2 MAPK1 SOS1 HRAS HNF1A SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PTPN6 PRKCB BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C1R C4B_2 C8A C2 C4A C6 C7 C9 C1QC HEL-S-62p C1QB C1QA C1S BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY HES1 HNF1A RBPJ GSK3B DVL1 FZD1 HEY2 HES7 WNT1 NOTCH2 NOTCH1 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI SOCS3 SOCS1 MAPK1 MYC SYK BAD SHC1 PIK3R1 IL2RG FAS JAK3 TNFSF6 JAK1 MAPK3 CRKL RPS6KB1 PIK3CA CBL IL2RA IL2RB BCL2 STAT5B GRB2 SOS1 HRAS FOS RAF1 IRS1 IKZF3 PTPN6 HEL-S-69p PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY IL5RA PTPN11 CISH PIK3R1 LYN PIK3CA STAT5B IL5 PIM1 GRB2 CSF2RB SDCBP PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY BRSK1 CRTC2 AKT1S1 CAB39 STK11 MAP2 SFN MARK4 STK11IP STRADA STRADB ETV4 CREB1 STK26 SIK3 SIK1 SIK2 MYC HEL2 MLST8 TSC1 GSK3B PRKAG1 SMAD4 SMARCD3 MTOR EZR PSEN2 YWHAQ HEL-S-130P HEL-S-1 PRKAA1 YWHAG PRKAA2 YWHAZ TSC2 PRKAB1 CDC37 RPTOR PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY PNKP APLF CSNK2A2 DNTT POLL PRKDC APTX CSNK2B NHEJ1 XRCC5 CSNK2A1 POLM PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS CD3G CD3E CD3D PRKCE MAP3K8 NCK1 KRAS CHUK LAT CDC42 TRAF6 IKBKG RAP1A GRAP2 MAP3K14 LCP2 FLNA PAG1 STIM1 TRPV6 ORAI1 CARD11 CSK PTPN6 PRKCB PRKCA ZAP70 BCL10 IKBKB SHC1 SLA2 STK39 WAS FYB1 FYN ITK PTEN PTPN11 GAB2 PDPK1 PLCG1 LCK CBL GRB2 SOS1 HRAS PTPRC PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY MAP3K8 MAP2K1 PRKCA MAPK3 BRAF KRAS FOS RAF1 NRAS MAPK1 PRKCB HRAS BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 PRKAG1 LEPR PRKAB1 ACACA CPT1A LEP BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY SMAD4 TGFB1 IL2 TGFBR1 TGFBR2 IL4 IL2RA TGFBR3 CD3G CD3E CD3D IFNG TOB2 TOB1 PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY GNA13 MAPK3 GNAO1 GNAZ PLCG1 GNAI3 S1PR5 S1PR4 GNAI1 CDC42 MAPK1 ARHA BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND CDK5 PPP1R1B FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C4B_2 C8A C2 C4A C6 C7 HEL-S-62p C9 MASP2 MASP1 MBL2 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY IGFBP5 SST GHRH IGFBP1 IGFBP2 GHRL IGFALS IGFBP6 IGF1 RAPGEF5 GH1 IGFBP4 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY MAP2K1 PTPN11 CEBPB MAPK3 JUN IL6 GRB2 IL6ST SOS1 IL6R CSNK2A1 HRAS SHC1 STAT3 FOS RAF1 JAK3 JAK1 PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY TNF TGFB1 IL2 IL18 EBI3 IL27 GATA3 IL27RA IL6 IL6ST IFNG TYK2 IL17A STAT2 STAT4 STAT3 IL12RB1 IL12B IL12A STAT1 TBX21 IL1B JAK1 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY MAPK3 PRKAR1B CREM PRKAR1A FOS PRKACG JUN CREB1 KCNIP3 OPRK1 BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY MAP2K1 ROCK1 MYL2 MAPK3 TLN1 PIK3CA ARHGAP5 MAPK1 ARHA HRAS ITGB1 SHC1 PIK3R1 PFN1 RAF1 FYN BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PDPK1 PLCG1 AP2A1 RPS6KB1 AP2M1 PFKM PFKL GSK3A PRKCE PFKP ARHGEF2 ARF1 BAD GSK3B PRKCZ LYN BTK EEA1 RAB5A VAV2 RAC1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY CSF2RA PXN SPP1 NOS2 VCAM1 VEGFC VEGFD ADAM12 VEGFA KCNJ15 F13A1 ADAM2 ADAM15 ADAM8 ITGB1 PAOX SRC TNC RAC1 CSF2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY CDK5R1 PRKAR1B PPP3CA PRKAR1A DRD1 DRD2 PRKACG PPP2CA PLCB1 CSNK1D CDK5 PPP1R1B BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY TNF IL10 HMOX1 STAT3 HEL-S-10 IL1A IL10RB IL10RA STAT1 IL6 JAK1 PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL17F TNF NOS2 IL18 SOCS3 IL6 CD3E IFNG CXCL9 IL17A STAT3 PIK3R1 NFKBIA IL18RAP IL12B RELA IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL18R1 IL23R STAT1 IL24 ALOX12B CXCL1 MPO IL19 IL23A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMB3 LAMA5 LAMB2 LAMA1 ITGB4 LAMB1 LAMA3 LAMC2 LAMC1 ITGA6 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY PROS1 F7 COL4A2 F2 COL4A1 COL4A4 COL4A3 SERPINC1 COL4A6 COL4A5 F2R FGA F10 PLG TFPI HEL-S-78p PROC PLAT ERAF PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY NFATC2 NFATC1 AKAP5 CABIN1 PPP3CA CHP1 BATF3 IL4 JUN IL3 IFNG RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 FOSL1 IL2 POU2F1 IL2RA FKBP1A PTGS2 NFATC3 FOS JUNB BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY CCL2 LDLR CSF1 ACAT1 IL6 LPL BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK4 CAMK1 CAMK1G CAMKK1 CALM1 CAMKK2 CREB1 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY CALCOCO1 MPG SRA1 PHB2 SET PDIA2 DSCAM POU4F1 LMO4 POU4F2 AP1B1 SAFB LCOR PGR TFF1 NCOA7 CHUK NCOR1 TRIM59 PRDM15 ATP5J HSF2 NDUFV3 NR3A2 XBP1 ABCA3 UBA3 DDX54 EBAG9 CEBPB KLRC3 AXIN2 NR0B1 HEL-S-130P CD82 GREB1 CCND1 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 JUN MED1 NCOR2 HDAC1 PRL MYC COL18A1 SMAD4 BRCA1 PCNA EP300 HEL-S-44 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY NFKB1 CD40 IKBKB CD40LG NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF3 TRAF6 IKBKAP IKBKG MAP3K14 PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY MCM7 CCNA2 MCM2 PPP2R1A PPP2CA MDM2 BRCA2 CHEK1 SMARCAL1 CEP164 NBN PPP2R2B ATRIP RAD51 RFC3 CDC6 RFC4 FBXW11 RFC2 CDK2 RPA1 HEL-S-1 HUS1 TIMELESS PLK1 YWHAZ FANCD2 RAD17 RAD1 ATR TOPBP1 CLSPN RAD9A BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKCA GRK4 PRKAR1B GNAS PRKAR1A PRKACG PRKCB PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY ROCK1 PXN SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 HEL-S-28 MAPK1 SRC ITGB3 F11R ITGAV COL16A1 TLN1 COL14A1 COL12A1 KDR PIK3C2A COL10A1 IGF1R TEM5 COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 COL13A1 COL11A2 MFGE8 COL5A2 COL9A1 COL9A3 COL9A2 PI4KB HEL114 IRS1 VEGFA COL1A1 PIK3R1 CSF1R VTN CSF1 EDIL3 SDC1 RAC1 PTPN11 MAPK3 COL17A1 RPS6KB1 PIK3CA CBL TGFBR2 PTK2B ARHA VAV3 CDKN1B CASP8 COL3A1 COL1A2 FGF2 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY EFNA1 PIK3CA CBL ARHGAP35 PAK1 TIAM1 GRB2 ARHA VAV3 SHC1 PIK3R1 SRC VAV2 INPPL1 RAC1 EPHA2 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2F GPR37 SUMO1 UBE2G1 UBE2G2 SNCAIP SEPT5 SNCA BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 SLC23A2 SLC23A1 SLC2A3 PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY EIF4EBP1 INS EXOC7 NCK1 SHC1 PIK3R1 PRKCZ EXOC4 SGK1 PARD6A EXOC3 GRB10 EXOC6 FOXO3A EXOC5 EXOC2 PTPN1 EXOC1 RAPGEF1 PTPN11 HEL-S-42 PDPK1 INSR CRK RPS6KB1 PIK3CA CBL PRKCI TRIP10 GRB14 GRB2 SOS1 F2RL2 NCK2 HRAS DOK1 IRS1 SH2B2 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY PRKCA GNG2 ADRBK1 PDPK1 CBL GNA14 GNB1 GNA15 PRKCE PLCB3 ARRB2 LYN RAB5A c-fgr PLCB1 PLCB2 CXCL8 PRKCB CXCR1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 AXIN2 DVL1 DVL2 DVL3 FZD5 CSNK1E GSK3A CSNK1A1 WNT3A APC CTNNB1 GSK3B SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY SRP9 PTPN11 CNKSR1 CEBPB CISH GAB2 OSM PRKACG PIK3CA IL3 HDAC1 STAT5B PIM1 GRB2 BCL2L1 ID1 YWHAG SHC1 PIK3R1 YWHAZ CSF2RB IL3RA PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL10 MMP9 EGR1 IL4 CREB1 IL6 TH IL5 IFNG BCL2L11 FOSL2 CSF2 CCL2 CDKN2A CDC2 NR3C1 ELF1 TCF7L2 CCND1 EDN1 FOS NFATC3 JUNB JUND CYR61 ATF3 GATA2 MAFG HIF1A NFATC2 CRTC1 NFATC1 DMP1 MT2A CBFB NTS BAG1 PENK FABP4 JUN TRIP6 COPS5 SP1 MYC GJA1 ACTA1 MYB HLA-A PTEN FOSB NPPA FOSL1 TGFB1 IL2 TIMP1 CDKN1B CTNNB1 ATF2 COL1A2 EP300 CXCL8 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY JUN SERPINA1 INS SFTPA2 SP1 C4BPB SFTPD CYP2C18 DSCAM NKX3-1 AP1B1 GCG NR2F2 PISD NFIA NFIB TFF1 VTN SCGB1A1 PRDM15 ATP5J NDUFV3 COL18A1 XBP1 CREBBP KLK3 APOB CEBPB SFTPA1 POU2F1 FOXA1 SHH CDKN1B BRCA1 FOS FOXA3 EP300 FOXA2 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY SLC25A1 ACLY PC PDHA1 ME1 CS SLC25A11 HEL-S-32 BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAP2K1 PRKCA TNF MAPK3 NFKB1 JUN MAPK1 MYC HRAS NFKBIA FOS RELA RAF1 PLCB1 CUZD1 PRKCB BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPG SNRPA1 SNRPB2 SNRPE SNRPD3 SNRPF DKFZp434N041 SNRPC SNRPA SNRPB U2AF1 SNRPD2 SNRPD1 PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY SMAD4 TGFB1 MAPK3 TGFBR1 TGFBR2 ACVRL1 FKBP1A INHBA ACVR2B TLX2 SMAD9 ACVR2A MAPK1 ID1 BMPR2 CSNK2B ARRB2 DKFZp781O1323 ACVR1 SMAD1 ENG BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY EGFR MYL2 PRKAR1B TLN1 PRKAR1A CAPNS1 PRKACG EZR CAPNS2 HRAS CXCR3 ITGB1 EGF ACTA1 BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY SMARCD1 SMARCC1 SMARCA4 SMARCC2 GTF2A1 ARID1A NR3C1 NF1 TBP PS1TP5BP1 SMARCE1 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY EGFR MAPK3 PIK3CA GHR GH1 GRB2 ERBB2 MAPK1 SOS1 MUC2 ARHA HRAS TFF2 BAD CTNNB1 ITGB1 SHC1 PIK3R1 CASP9 TFF1 TFF3 APAF1 BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY PRKAR1B CARM1 PRKAR1A PRKACG CREB1 EP300 RXRA CREBBP RARA BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY DPF2 ZBTB7A ITGB1 CCT4 PIK3R1 FOS MTOR PIK3CA CASP3 JUND BIRC5 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY PSMB6 HEL-S-276 PSMA4 PSMB2 RPN2 PSMB3 PSMA2 RPN1 UBE3A UBE2A BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY PRKCA ADRA1B PRKCB BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CCR5 FAS CD3G CD3E TNFSF6 CD3D BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY PDE6G RHO SAG PDE6A SLC25A22 GRK1 SLC25A18 RCVRN BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY MAP2K1 PRKCA MAPK3 MPL PLCG1 THPO PIK3CA JUN STAT5B GRB2 SOS1 CSNK2A1 HRAS SHC1 STAT3 PIK3R1 FOS STAT1 RAF1 PRKCB PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY EGFR SDC2 NRAS IL6 NGF IFNG LMO4 KRAS NTRK1 AFDN KDR IFNGR1 IGF1R PAG1 ANGPT1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 MAP2K1 PTPN11 GAB2 IL2 GNAI3 PIK3CA GNAI1 LCK ARHGAP35 IL2RA IL2RB IL6ST GRB2 IL6R SOS1 HRAS FRS2 ARHA MAP2K2 FRS3 EGF NTF4 NTF3 NTRK3 RAF1 STAT1 NTRK2 BDNF PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY TNF KSR1 MADD SPHK2 CYCS BIRC3 AIFM1 PAWR PRKRA MAPK1 EIF2AK2 PDGFA MYC BAD MAP2K4 NFKBIA MAP3K1 PRKCZ BAX RELA CRADD TRADD TRAF2 SMPD1 TNFRSF1A RIPK1 HEL-S-31 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HEL-S-130P MAP2K2 EGF CASP8 RAF1 BAG4 FADD PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY KSR1 WASL WASF2 ARPC1B ACTR3 ACTR2 PAK1 SLA NRAS DKFZp686P11128 ACTN4 DOCK4 MAPK1 MYOCD HEL-S-47e ACTA2 NHERF2 SIPA1 NCK1 BRAF BLK ARPC4 KRAS YES1 ARPC5 BAIAP2 ARPC2 ARPC3 c-fgr PIN1 RAB4A FOS PRKCA EIF2AK2 MYC HEL2 SHC1 PIK3R1 LYN PPP2CA GRB10 FYN RAC1 PTPN1 PTPN11 PIK3CA LCK MAPK8 GRB2 SOS1 ARHA MAP2K2 RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 IQGAP1 VAV2 AFDN RAP1A SPHK1 RAPGEF1 ITGAV S1PR1 PPP2R2B CRK PAG1 STAT5B CSK JUND PIK3R5 SFN NHERF1 JUN PIK3CD PIK3R3 PIK3R2 MAPK9 STAT3 PPP2R1A MAPK10 RAB5A PTEN MAP2K1 MAPK3 PLCG1 CBL ARHGAP35 YWHAQ HEL-S-1 NCK2 HRAS YWHAG YWHAZ DOK1 ARAP1 STAT1 USP6NL BRK1 RPS6KA3 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY PDE6G RDH12 RHO RGS9BP SAG PDE6A RDH5 GNB1 LRAT GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F RPE65 GRK1 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY EIF2S2 EIF2S1 NFKBIA NFKB1 DNAJC3 CHUK RELA EIF2AK2 MAP3K14 BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY NME2 PPP3CA SYNJ1 PPP3CC AP2A1 EPN1 AP2M1 CALM1 PICALM BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY PRKAR1B PRKAR1A KDR FLT4 PRKACG BDKRB2 CALM1 VEGFA CHRNA1 KNG1 CHRM1 RYR2 ACTA1 PDE2A PDE3B SLC7A1 PDE3A FLT1 TNNI1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY ACTN1 DOCK1 GRB7 PXN WASL PAK1 ROCK2 ARHGEF7 RRAS MAPK1 NCK1 MAP2K4 BRAF SRC YES1 RAP1A ITGB5 PTPN21 RAPGEF1 ITGAV SH3GL1 ARHGAP26 TLN1 KLF8 CRK BMX CCND1 HEL114 JUN ASAP1 MAPK9 MAPK8IP3 PIK3R1 ELMO1 ACTA1 FYN RAC1 MAP2K1 ARHGEF28 PLCG1 PIK3CA ARHGAP35 MAPK8 MMP14 GRB2 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY TNF CYCS BIRC3 NFKBIA FAS CHUK RELA CRADD TRADD TRAF2 TNFRSF1A CASP2 RIPK1 TNFSF6 MAP3K14 NFKB1 CASP6 MAPK8 BCL2 CASP9 CASP8 MAP3K5 CASP3 BAG4 FADD DFFB DFFA TRAF1 APAF1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY EGFR TNKS XRCC5 TERF1 MAPK1 IFNG RBBP4 BLM NBN PINX1 SMG6 PARP2 TINF2 DKC1 POT1 ATM TERF2IP WRN ACD PTGES3 IRF1 MRE11A ZNFX1 HUS1 HNRNPC CCND1 FOS RAD50 RAD1 NCL RAD9A JUN HDAC1 IFNAR2 SP1 MAX WT1 MYC SP3 NR2F2 HEL2 TERF2 SMG5 SIN3B TERT SIN3A SAP30 MAPK3 TGFB1 SAP18 IL2 RBBP7 NFKB1 MTOR RPS6KB1 MXD1 CDKN1B EGF HDAC2 UBE3A BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA CREB1 SP1 MAPK1 RB1 MAP2K2 MAP2K3 MAPK14 PIK3R1 MAP3K1 RELA PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY PIAS2 UBE2I SUMO1 RAN MDM2 HDAC1 RANBP2 PIAS1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY DNAJB1 DNAJB6 NFE2L2 APLP1 RPSA GFAP LAMA1 LAMB1 PRNP LAMC1 BCL2 HEL-S-89n BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY NFKB1 IKBKB NFKBIA MAP3K1 CHUK TNFAIP3 RELA TRAF2 TANK TRAF3 RIPK1 IKBKAP TRAF1 IKBKG TNFRSF1B MAP3K14 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY HGS PXN ADRBK1 MMP9 CXCL12 PAK1 CD3G CD3E HEL-S-15 CD3D MAPKAP1 MLST8 RICTOR BLK SRC YES1 RALB c-fgr CDC42 ITGAV CRK FOXO1 PAG1 STAT5B UBQLN1 RGS1 RHOB CSK VPS4B VPS4A SSH1 PTPN6 ARR3 PIK3R5 GNA13 GNG2 GNB1 PIK3CD ITGA4 PIK3R3 ITGA2 PIK3R2 ITGA1 STAT2 BAD STAT3 PIK3R1 ARRB2 PRKCZ LYN ITGA7 ITGA6 FYN RAC1 PTEN PTPN11 PDPK1 GNAZ MTOR GNAI3 PIK3CA GNAI1 LCK ITCH PTK2B PTPRC ARHA ITGB1 GNAO1 PLCB3 CXCR4 STAT1 PLCB1 HLA-DRA VAV1 PLCB2 LIMK1 BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY SHC1 PIK3R1 PIK3CA IGF1 GHR IGF1R GH1 FOXO3A HEL-S-44 HRAS BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NCK1 HEL-S-276 WASL WASF2 NCKAP1 NTRK1 WASF1 ACTA1 ABI2 PIR WASF3 RAC1 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY CYP1A2 CYP2E1 PTGS2 PTGS1 NR1I3 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY ADAM10 RBPJ NR1C2 JUN HDAC1 MAPK1 NOTCH1 MYC CSNK2A1 APC NEDD4 GSK3B MAP3K7 CREBBP MAPK3 PSEN1 AXIN1 FBXW11 NLK TLE5 DVL1 CTBP1 FZD1 FRAT1 MAP3K7IP1 CSNK1A1 HNF1A CTNNB1 CCND1 PSENEN FOS LRP6 WIF1 PPP2R5D DKK1 APH1B WNT1 DTX1 NKD1 DKK2 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAP2K1 PRKCA MAPK3 NFKB1 CRK PLCG1 CXCL12 PIK3CA MAPK1 PTK2B HRAS PIK3R1 RELA CXCR4 RAF1 PRKCB PIK3C2G BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY FAAH CNR2 BAAT PLD3 PLD2 CNR1 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY CLTA MYOD1 BIRC3 NRAS CEBPA KRAS NCOR1 IQGAP1 CREBBP HES1 ADA CEBPB CDKN2A CEBPD ELANE NLK KITLG KIT LEF1 CCND1 SPI1 CCNB1 SLC25A3 PPP3CA LECT2 YEATS4 UBE2I RAG2 CD34 PAX5 SND1 ADORA2B COPA PIM1 TFEC SP1 PRTN3 MAD1L1 MYC HEL-S-11 H2AZ1 ZFHX3 GSTM1 ATP2B1 CBX4 LYZ CSF1R HIPK2 SKI MYF6 ETS2 SIN3A MYB MAP3K7 CDK6 ZFPM1 GATA1 CASP6 GATA3 BCL2 MAP3K7IP1 HRAS CDKN1A CDKN1B PTGS2 COL1A2 TRIM28 EP300 WNT1 MPO BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY RBBP7 BMI1 HDAC1 RBBP4 CBX4 HDAC2 YY1 SUZ12 PHC1 EED COMMD3-BMI1 EZH1 EZH2 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA13 MAPK3 GNAZ GNAI3 GNAI1 GNA14 PAK1 JUN MAPK8 GNA15 GNA11 MAPK1 ARHA MAPK14 GNAO1 FOS IRS1 RAC1 S1PR2 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY TNF IL10 IFNA1 IFNB1 IL15 IL13 IL7 IL4 IL3 IL6 IL5 PDGFA IFNG IL11 CSF1 CSF3 CSF2 TGFB1 IL2 HLA-DRB5 IL1A HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 CXCL8 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PRKCA PIK3R1 PLCG1 PIK3CA PLCB1 VAV1 PRKCB BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY MAP2K1 MAPK3 PRKAR1B PRKAR1A PRKACG PIK3CA IGF1R GRB2 MAPK1 SOS1 HRAS ADCY1 BAD SHC1 PIK3R1 RAF1 RPS6KA1 IRS1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY PPP3CA IL13 IL18 JUN CD3G CD3E CD3D IFNG MAPK9 PIAS2 STAT3 IL18RAP PPP3R1 TBX21 PRF1 CREBBP TGFB1 IL2 IL2RA MAPK8 IRF1 STAT4 IL18R1 FOS ETV5 CD80 HLA-DRA BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY RB1 SP3 NFYA NFYB SP1 NFYC BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN EPYC KERA PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGAV ITGB7 ITGB6 ITGB4 ITGA4 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGAM ITGA6 ITGAX ITGB5 PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY IL10 MYOD1 IFNB1 KAT2B KAT2A RBL1 TFDP1 NR1i1 CREB1 IL5 IRF7 RBBP4 NCOR1 E2F4 E2F5 RUNX1 CREBBP ITGB5 CEBPB NR3C1 FOXO4 CDK2 FOXO1 NR2A1 FOS ATF3 CBFB NCOA1 JUN HDAC1 SP1 MAX RUNX2 MYC SP3 GSC SKI SIN3B SIN3A FOXO3A SKIL SAP30 SMAD2 SMAD4 SAP18 CITED1 RBBP7 MED15 SNIP1 TGIF1 TGIF2 LAMC1 FOXH1 RUNX3 CTBP1 GATA3 DLX1 FOXG1 CDKN2B DCP1A CDKN1A ATF2 HDAC2 TCF3 COL1A2 NKX2-5 EP300 MEF2C CDK4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY HIC1 FHL2 NQO1 ATM MAPK8 GADD45A RPA1 NFKBIB DNAJB1 CDKN1A BAX TAF1 MDM2 EP300 ABCB1 HIF1A BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY CD40 CD40LG FAS HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 TNFSF6 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNG2 GNB1 HDAC1 SMO RBBP4 GSK3B ARRB2 SIN3B SIN3A CSNK1G3 CSNK1D CREBBP CSNK1G2 SAP30 CSNK1G1 MAP2K1 SAP18 RBBP7 GNAZ GNAI3 GNAI1 FBXW11 CSNK1E PIAS1 CSNK1A1 SHH IFT172 GLI3 PTCH1 KIF3A RAB23 GNAO1 SUFU HDAC2 SPOP MTSS1 FOXA2 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL13 EGR1 PPP5C IL4 CREB1 TSG101 IL6 IL5 MAPK1 IFNG SMARCD1 SMARCC1 SMARCC2 GSK3B BAX KRT5 SGK1 TBP MAPK11 CREBBP KRT14 CSF2 NR3C1 PRKACG POU2F1 SELE STAT5B IRF1 FOS NR1I3 POMC SPI1 NFATC1 SFN SUMO2 NCOA1 JUN HDAC1 PRL MAPK9 BGLAP MAPK14 SMARCA4 MAPK10 RELA MDM2 TBX21 MAPK3 IL2 NFKB1 GATA3 MAPK8 CDK5 CDKN1A CDK5R1 HDAC2 CSN2 KMT5B POU1F1 STAT1 EP300 FKBP4 FKBP5 CGA PCK2 CXCL8 AFP PBX1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY SMAD4 SKP2 TGFB1 CDKN2A CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CDKN2B RB1 CDKN1A CDKN1B CCND1 GSK3B ATR CDK6 CDK4 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY NCF2 CYBB CYBA NOXA1 WASF2 CYFIP2 ARPC1B NCKAP1 ACTR3 ACTR2 PAK1 JUN PIP5K1A IQGAP3 HEL-S-15 HEL-S-47e MAPK9 MAP2K3 MAPK14 STAT3 MAP2K4 MAP3K1 ARPC4 ARPC5 IQGAP1 WASF1 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 MAP2K6 PIP5K1C CRK ARHGAP5 MAPK8 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 BRK1 NCF1 LIMK1 BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY EGFR TNF PRKCA HOXA7 JUN SP1 MAPK1 PRKCE CEBPA MAP2K3 MAPK13 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 FAS CHUK RELA ETS2 PPP2CA TRAF2 TNFRSF1A RIPK1 TNFSF6 MAP3K14 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH EGF FOS MAP3K5 PRKCQ RAF1 PRKCB TNFRSF1B BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY LPAR1 PRKACG LPAR2 LPAR3 PRKAG1 ARHA BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY H3C15 NR0B1 MED1 HDAC1 SRA1 NCOR2 GRIP1 SPEN PHB2 PPARGC1A HDAC3 HDAC6 CCND1 CARM1 GTF2A1 HDAC5 HDAC2 BRCA1 TBP EP300 MEF2C CREBBP PELP1 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY MAPK7 MAP2K5 MAP3K2 EGR1 NRAS CREB1 RPS6KA5 MAPK1 MAP2K3 MAPK14 BRAF KRAS TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS CDK5R1 NTF3 FOS RIT1 RAF1 RIT2 RPS6KA1 MEF2C MAPKAPK2 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY TYK2 STAT4 CD2 CXCR3 CCR5 IL12RB1 NOS2 CD3G CD3E IFNG CD3D PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY EGFR PXN MMP9 LPAR1 LPAR2 LPAR3 TIAM1 ADCY9 IL6 PRKCE ADCY3 ADCY1 NHERF2 LPAR4 ADCY8 ADCY6 SRC GSK3B CRK FOS GNA13 GNG2 GNB1 ARHGEF1 PLD2 JUN TRIP6 PIK3R1 NFKBIA RELA LYN PRKD1 RAC1 HBEGF NFKB1 GNAZ PLCG1 GNAI3 GNAI1 GNA14 GNA15 GNA11 MMP2 PTK2B HRAS ARHA GNAO1 PLCB3 CASP3 ADRA1B CXCL8 PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY MAP2K6 TAOK3 ATM TAOK1 GADD45A TAOK2 MAP3K7IP1 MAP2K3 MAP3K6 MAPK14 MAP3K1 MAP3K10 MAP3K5 TXN TRAF2 GADD45B MAPK11 MAP3K7 GADD45G TRAF6 RAC1 BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY TRPV4 ADCY1 KCNQ2 KCNQ3 GNAS KCNQ5 TRPC3 GUCY1A2 TRPC5 GUCY1B1 TRPC4 BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2S2 EIF2S1 EIF2S3 EIF5 EIF2AK1 GSK3B EIF2AK4 EIF2B5 EIF2AK2 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BIRC2 CASP6 BIRC3 BAK1 AIFM1 BCL2 DIABLO CASP9 CASP8 BAX BIK CASP3 DFFB DFFA APAF1 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 PRKCE IFNG KRAS STAM2 SOCS2 MAPK11 CISH CDK2 STAT5B FOS PPP2R5D IRS1 IKZF3 PRKCB JUN SOCS3 SOCS1 MYC SYK MAPK9 MAPK14 SHC1 STAT3 PIK3R1 IL2RG FYN JAK3 JAK1 MAP2K1 PTPN11 GAB2 MAPK3 IL2 PIK3CA LCK IL2RA MAPK8 IL2RB BCL2 GRB2 SOS1 PTK2B HRAS ARHA MAP2K2 RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY SH3GL2 ROCK1 ROCK2 PLD2 JUN PIP5K1A HEL-S-15 MAP2K3 LIMK2 MAP2K4 MAPK12 PRKCZ PARD6A ACTA1 SCAI HEL70 CDC42 RDX MRTFA CIT PTEN PKN2 MAP2K6 PIP5K1C MYL2 TLN1 EZR MAPK8 F2RL2 ARHA PKN1 CDKN1B ITGB1 ATF2 SLC9A3 HEL114 FOS STM7 CYR61 LIMK1 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 NBN EWSR1 RAD51 FANCL CDK2 ATM FANCA MRE11A FANCC FANCE PRKDC FANCG BRCA1 FANCF PCNA NPM1 RAD50 FANCD2 ATR TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY BARD1 FANCC FANCE FANCG BRCA1 FANCF FANCD2 FANCA BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY NFATC2 NFATC1 F2 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 MAPK1 MAPK14 PIK3R1 NFATC4 CAMK4 GSK3B ACTA1 CREBBP NPPA MAP2K1 CTF1 MAPK3 HEL-S-99n PRKAR1B PRKAR1A HAND2 HBEGF MYH2 HAND1 PRKACG RPS6KB1 IGF1 PIK3CA MAPK8 CSNK1A1 HRAS EDN1 GATA4 NFATC3 NKX2-5 RAF1 MEF2C FGF2 PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY SDC2 TACI NF1 MAPK1 EPHB2 ITGA2 SRC BAX CSF2 MAPK3 TGFB1 CAV2 EZR TRAPPC4 MAPK8 MMP2 HRAS ARHA ITGB1 KNG1 LAMA1 LAMA3 CASP3 CASK SDCBP CXCL8 BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY CASP3 DFFB TOP2A DFFA HMGB2 HMGB1 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PRKCA PLCG1 P2RY2 PTK2B PRKCB BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY TNF MADD PAK1 JUN MAP2K4 MAP3K1 CRADD TRADD TRAF2 MAP3K7 TNFRSF1A CASP2 RIPK1 SPTAN1 MAPK8 RB1 LMNB2 PRKDC CASP8 CASP3 ARHGDIB BAG4 LMNA FADD DFFB DFFA PARP1 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY NUMA1 KPNA2 AURKA RAN KIF15 RANBP1 RCC1 HCTP4 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY SQSTM1 CYCS BIRC2 BIRC3 NGFR NGF HEL-S-47e CHUK NTRK1 BCL2L11 TRAF6 IKBKG NSMCE3 OMG RTN4R BEX3 MAGEH1 ZNF274 BEX1 RTN4 NDN SORT1 PSENEN RHOB APH1B FURIN RIPK2 MAPK9 ADAM17 HEL2 BAD IKBKB SHC1 PIK3R1 PRKCZ IRAK1 MAPK10 RAC1 MYD88 PSEN1 CASP6 PIK3CA PRKCI APP MAPK8 ARHA DIABLO MAGED1 CASP9 NTF4 NTF3 CASP3 SMPD2 PLG MMP7 BDNF APAF1 MMP3 PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY MAP2K6 MAP2K1 TNF MAPK3 VCAM1 IL18 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 DEFA1B NLRP1 IL1B PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY WASF2 CYFIP2 CTNND1 NCKAP1 TIAM1 CSNK2A1 CSNK2A2 PIK3R1 SRC CSNK2B IQGAP1 VAV2 CDC42 RAC1 AFDN RAP1A CTNNA1 JUP ITGAE RAPGEF1 ARF6 ITGB7 PIP5K1C CRK PIK3CA TJP1 ARHA CTNNB1 CCND1 KLHL20 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL5RA HLA-DRB5 CCL11 HLA-DRB4 IL4 HLA-DRA IL6 HLA-DRB3 CCR3 IL5 IL1B HLA-DRB1 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY EGFR DOCK1 CTRC MMP9 GPLD1 SRC VTN ITGB3 ITGAM RAC1 ITGB5 ITGAV TGFB1 PLAUR CRK ELANE VLDLR ITGB1 FGA HGF FPR1 PLG KLK4 HEL-S-78p FPR2 PDGFD CTSG FPRL2 NCL MMP3 MMP12 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY HGS ROCK1 PXN SH2D2A CAMKK2 MAPK1 ARF1 MAP2K3 NCK1 BRAF SRC ITGB3 IQGAP1 MAPK11 CDC42 FLT1 CTNNA1 MAP2K6 ITGAV KDR FBXW11 FES HEL114 PRKAB1 PTPN6 PRKCB HSP90AB1 PRKCA MYOF VEGFA MAPK14 NEDD4 PIK3R1 VTN PRKAG1 GRB10 FYN MAP2K1 PTPN11 SHB MAPK3 PDPK1 PLCG1 PIK3CA CBL GRB2 PTK2B NCK2 ARHA MAP2K2 PRKAA1 CTNNB1 PRKAA2 RAF1 MAPKAPK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY ARF6 MAPK3 RAB11FIP3 PLAUR KALRN RAB11A PLD2 TIAM1 PIP5K1A MAPK1 ARHA ARF1 RAC1 BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY EGFR EGF UBE2D1 ERBB3 NRG1 BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY KITLG CREB1 KIT EP300 RPS6KA1 BCL2 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY EGFR MAP2K1 MAPK14 EGF THRA MAP3K1 ZBTB16 NR1A2 NCOR2 RXRA RARA BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY PDPK1 NFKB1 AXIN1 LBP PIK3CA DVL1 FZD1 LEF1 EIF2AK2 APC CTNNB1 CCND1 PIK3R1 GSK3B RELA PPP2CA GJA1 WNT1 MYD88 BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY PITX2 AXIN1 LDB1 DVL1 FZD1 MED1 HDAC1 LEF1 APC CTNNB1 TRRAP GSK3B EP300 WNT1 CREBBP KAT5 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY CD8A CD58 CD34 KITLG IL3 IL6 CD3G CD3E CD3D IL17A CD2 CSF3 CXCL8 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY NCF2 NFATC2 NFATC1 PPP3CA PPP3CC CAMK1 CAMK1G CALM1 PAK1 MAPK1 MAP2K3 MAPK14 NFATC4 NFKBIA MAP3K1 RELA RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 HRAS MAP2K2 NFATC3 FPR1 RAF1 PLCB1 NCF1 PIK3C2G BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY PSEN1 RBPJ AXIN1 DVL1 FZD1 BTRC NOTCH1 ADAM17 APC HNF1A CTNNB1 GSK3B WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB5 CCL11 HLA-DRB4 IL3 HLA-DRA HLA-DRB3 CCR3 IL5 HLA-DRB1 CSF2 CCL5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY KDR FLT4 VEGFC VEGFD NRP1 VEGFA NRP2 VEGFB FLT1 BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY TNF NR3C1 HSD11B1 RETN RXRA LPL PPARG BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY PIN1 CCNB1 MAPK3 PRKAR1B CDC2 PRKAR1A PRKACG CAP1 PAQR7 PAQR5 MAPK1 HRAS ADCY1 PGR MYT1 ACTA1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY PDGFRA RALBP1 NCF2 TRIO MYL2 RPS6KB1 PIK3CA PAK1 CDK5 CDK5R1 PIK3R1 MAP3K1 PPP1R12B WASF1 VAV1 RAC1 LIMK1 CHN1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A1 MMP9 COL4A4 COL4A3 COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 MAPK3 TGFB1 COL17A1 COL16A1 LAMA5 COL14A1 COL12A1 COL10A1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 MET COL3A1 HGF COL1A2 CASK SDCBP MMP7 CCL5 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY CASP9 CASP10 CASP8 CASP3 ARHGDIB ARHGAP5 JUN PRF1 PARP1 APAF1 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY LBP JUN SOCS3 IL6 MYC TNFSF11 LMO4 CRP HEL-S-125m MAPK14 A2M STAT3 PIK3R1 MAP2K4 PTPRE MCL1 MAPK11 RAC1 JAK1 MAP2K6 PTPN11 CEBPB GAB2 CEBPD PIK3CA FOXO1 GRB2 IL6ST TIMP1 IL6R PIAS1 SOS1 IRF1 BCL2L1 TYK2 FOS JUNB STAT1 VAV1 BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY CDK5R1 VLDLR LRP8 DAB1 FYN RELN CDK5 PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 CREB1 IL6 TH MAPK1 IFNG DUSP8 MAPK11 DUSP10 KAT5 RUVBL2 HES1 POU2F1 SELE CCND1 FOS JUNB JUND ATF3 PRKCA ARG1 CBFB NOS2 NF1 JUN INS SOCS3 GADD45A PPARGC1A MAPK9 MAPK14 HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 DUSP5 MAPK8 BCL2 MMP2 SERPINB5 BCL2L1 RB1 ATF2 BRCA1 EP300 DDIT3 CXCL8 CDK4 IL23A BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY PKN1 CDC2 MAP2 PRKACG PPP2CA PRKAG1 NUP85 AKAP9 PRKCE PCNT ARHA PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY NFATC2 PRKCA NFATC1 AKAP5 CABIN1 PPP3CA CHP1 SFN RAN MEF2D NUP214 PIM1 PRKCE CSNK2A1 RCAN1 MAPK9 MAP3K8 KPNA2 HEL2 BAD MAPK14 CAMK4 MAP3K1 GSK3B PRKCZ PPP3R1 CREBBP MAPK3 MAPK8 FKBP1A BCL2 YWHAQ HEL-S-1 CSNK1A1 BCL2L1 YWHAG PRKCH NFATC3 YWHAZ CASP3 PRKCQ EP300 PRKCB BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY CHRNG MUSK BAD RAPSN PIK3R1 PIK3CA TERT FOXO3A TNFSF6 PTK2B CHRNB1 PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY ADAM10 NUMB RBPJ KDM1A MAML2 MAML1 RAB11A ADAM12 IL4 HDAC1 NCOR2 SPEN NOTCH1 MYC RBBP8 NCOR1 FBXW7 SKP2 NOTCH3 MYCBP PSEN1 DLL3 DLL4 DNER CBL JAG2 MIB1 CTBP1 GATA3 MFAP5 MFAP2 CNTN1 ITCH LNX1 ENO1 CDKN1A CCND1 PSENEN YY1 SKP1 EP300 APH1B NOTCH2 DTX1 FURIN PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY BMP4 BMP2 BMPR1A NUP214 MAPK1 SMAD9 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 MAP3K7IP1 CHRDL1 ZFYVE16 SOSTDC1 CER1 BAMBI CTDSP1 AHSG CTDSP2 FST CTDSPL HFE2 BMPR2 RGMB BMP6 RGMA DKFZp781O1323 GREM1 SMAD1 NOG BMP7 PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY IFNA17 TNF TNFRSF18 IFNA10 IFNA1 IFNA21 EGR4 CD8A IF1AA9 EGR1 NRAS CD3G CD3E MAPK1 CD3D PRKCE IFNG BRAF KRAS TNFRSF9 CD8B1 STAT4 FOS NFATC3 JUNB PRKCB NFATC2 PRKCA NFATC1 PPP3CA JUN IFNAR2 IFNAR1 MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 FOSL1 MAPK3 IL2 IL2RA MAPK8 IL2RB HRAS MAP2K2 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 IFNA16 BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY PROS1 F7 FGA F2 F10 F3 SERPINC1 F5 TFPI HEL-S-78p PROC F2R PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY EGFR YBX1 NOX4 INS SOCS3 PRL LEP PRLR SHC1 STAT3 PIK3R1 BLK CSF1R SRC CSF1 ITGB3 YES1 LYN LAT CDH2 LEPR c-fgr FYN PTPN1 FER INSR CRK PIK3CA LCK STAT5B GRB2 TRPV6 ARHA TYK2 EGF CSK CSN2 DOK1 ITGA2B TXN SPRY2 IRS1 FCGR2A BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL2 CD8A IL7 EPO IL4 IL3 IL6 IL5 IL9 IL11 CSF1 CSF3 CXCL8 CSF2 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY NFATC2 TNF NFATC1 EGR4 BATF3 IRF4 EGR1 IL4 DGKA JUN IL3 SLC3A2 IKZF1 IL5 PTPRK GBP3 IFNG PPARG EGR2 RNF128 CD40LG TBX21 FOXP3 PTPN1 TNFSF6 CSF2 CTLA4 FOSL1 IL2 POU2F1 IL2RA GATA3 ITCH PTGS2 NFATC3 FOS CASP3 JUNB PRKCQ CXCL8 CDK4 BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY HDAC9 MYOD1 CAMK1 CAMK1G PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY EGFR VEGFA INS PIK3CD EIF2AK2 PIK3R3 PIK3R2 LMAN1 KPNA2 ITGA1 SHC1 STAT3 PIK3R1 CSF1R SRC CSF1 CREBBP JAK3 PTPN1 JAK1 INSR KDR PIK3CA STAT5B RAB4A GRB2 PIAS1 SOS1 ITGB1 EGF MET HGF STAT1 ATR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK3 EP300 CREBBP MAPK1 PELP1 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY CD40 CR2 CR1 HLA-DRB5 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 FCGR2B HLA-DRB1 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY DLG4 PCLO DLG2 GRIN1 GUK1 NRXN3 NCAM1 SPTAN1 CASK ADD1 ACTA1 SPTBN1 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAP2K1 ROCK1 MAPK3 MAPK8 MAPK1 ARHA HRAS MAP2K2 HNF1A MAP4K2 MAP3K1 ACTA1 MAL RAF1 CDC42 RAC1 LIMK1 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY TYK2 STAT3 STAT1 SOCS3 STAT5B JAK3 JAK1 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CRY2 CRY1 CSNK1E PER1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY ITGB1 IL1A VCAM1 CD34 MADCAM1 SELL PECAM1 ITGA4 ICAM2 CXCL8 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY SOCS3 MAPK14 SHC1 PIK3R1 LYN BTK SH2B3 VAV2 PLCG2 TEC RAP1A RAPGEF1 PTPN11 CRKL EPOR NFKB1 PLCG1 CBL EPO MAPK8 BCL2 STAT5B GRB2 SOS1 HRAS TRPC6 BCL2L1 STAT1 PTPN6 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY PTCH1 GLI3 PRKAR1B PRKAR1A SUFU GSK3B PRKACG DYRK1A SMO DYRK1B SHH PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B RFWD2 CCNG1 GSK3B CSNK1G3 CSNK1D KAT5 CSNK1G2 CREBBP CHEK1 CSNK1G1 RPL5 DYRK2 PIN1 SETD8 SKP2 SETD7 CDKN2A TP53AIP1 RASSF1 PPP1R13L KAT8 RPL23 FBXO11 CDK2 PPM1D ATM PTPA SMYD2 CSNK1E E4F1 MDM4 CSNK1A1 NEDD8 CHEK2 ATR UBE2D1 MAPK9 MAPK14 RPL11 HIPK2 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY MAP2K1 PTPN11 MAPK3 INSR SLC2A4 PIK3CA JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY BIRC2 CLTC BIRC3 PIK3CD PIK3R3 PIK3R2 MAPK9 SYK MAPK14 IKBKB PIK3R1 SRC MAP3K1 FAS CHUK MAPK10 BTK SMPD1 MAPK11 RIPK1 IKBKG TNFSF6 MAP2K6 CASP10 PDPK1 EZR PIK3CA MAPK8 FAIM2 CASP8 CASP3 FADD RFC1 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY RBX1 UBE2I UBA2 SAE1 EDEM1 FBXO2 SEC61A1 GANAB MAN2A2 CANX MAN1A2 GCS1 UGGT1 SKP1 MAN1A1 MAN2C1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF2S2 EIF4A2 SUI1 EIF2S1 AAG1 EIF2S3 EIF4A1 EIF4G1 EIF3A EEF2K EIF5 EEF2 EIF6 EIF4E EIF1AX PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK MAP3K1 CHUK BTK POU2F2 VAV2 PLCG2 TRAF6 IKBKG PAG1 CARD11 FOS CSK CD19 SH3BP5 CD72 IBTK CD22 PTPN6 NFATC1 PPP3CA PPP3CC JUN CSNK2A1 SYK BCL10 MAPK14 IKBKB SHC1 PIK3R1 NFKBIA RELA LYN MAP3K7 CAMK2G RAC1 PTEN CD79B CD79A MAP2K1 MAPK3 PDPK1 NFKB1 PIK3CA MAPK8 GRB2 SOS1 HRAS PTPRC NFKBIB DOK1 BCL2A1 RAF1 FCGR2B MAP4K1 PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY GNA13 GNG2 MMP9 GNB1 ROCK2 NRAS GNAL SHC1 PIK3R1 SRC KRAS HEL70 NR3A2 MAPK11 PELP1 HBEGF GNAZ GNAI3 GNAI1 PIK3CA IGF1R GNA14 GNA15 GNA11 GRB2 SOS1 MMP2 HRAS ARHA GNAO1 PLCB3 PLCB1 PLCB2 STRN BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY FZD1 DKK1 WNT8A WNT8B DKK2 BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY F8 PROS1 SERPING1 COL4A2 KLKB1 F2 COL4A1 COL4A4 COL4A3 SERPINC1 F5 COL4A6 COL4A5 F9 F11 F2R FGA KNG1 F10 HEL-S-78p PROC PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY ITGB8 ITGAV ITGB7 ITGB6 PLAUR VCAM1 TGFBR1 ITGA4 VTN EDIL3 SDC1 MADCAM1 FBN1 CYR61 ITGB5 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY TNF USH1C LIN7A NFKB1 IFNGR1 TAX1BP3 IFNGR2 IFNG WT1 RB1 IKBKB NFKBIA RELA TNFRSF1A TNFRSF1B BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY ACTN1 CTNNB1 ACTN2 HEL114 LRRTM2 CSK CTNNA3 CTNNA2 PECAM1 CTNNA1 BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY RB1 SKP1 TFDP1 FBXW7 CDK2 CDC34 CCNE1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA3 GPX1 GABRA2 GABRA6 GABRA5 PRKCE GABRA4 HEL-S-44 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY SPHK1 S1PR1 ITGAV MAPK3 GNAZ KDR PLCG1 GNAI3 GNAI1 VEGFA MAPK1 ARHA GNAO1 PTGS2 ITGB3 ABCC1 PLCB2 RAC1 BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RANBP1 RCC1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY RB1 SKP2 SKP1 TFDP1 CDK2 CDC34 CCNE1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY NFATC2 PRKCA NFATC1 PPP3CA PPP3CC CALM1 JUN SYK MAPK14 SHC1 NFATC4 MAP3K1 LYN BTK RAC1 CD79B CD79A MAP2K1 MAPK3 PLCG1 MAPK8 GRB2 SOS1 HRAS NFATC3 FOS RAF1 VAV1 PRKCB BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY SHC1 LAMTOR5 CREB1 GRB2 SOS1 PTK2B HRAS PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY NOS2 EIF4EBP1 GDI1 JUN CREB1 USF1 KRT19 RPS6KA5 PPARGC1A CSNK2A1 CSNK2A2 ATF1 MAPK14 CSNK2B RAB5A MAPK11 EIF4E CEBPB ATF2 PTGS2 MAPKAPK3 HEL-S-102 DDIT3 MEF2C MAPKAPK2 MAPKAPK5 RPS6KA4 BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY EGFR PAK1 JUN CHRNA1 SP1 DAG1 MAPK1 DMD AGRN PAK4 ACTA1 CDC42 NRG1 RAC1 NRG2 MUSK NRG3 MAPK3 RAPSN LAMA4 DVL1 MAPK8 ITGB1 CHRM1 GIT2 LAMA3 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY TNF C6 C7 VCAM1 IL6 ITGA4 ITGB1 KNG1 HEL-S-62p IL1A SELP SELPLG CXCL8 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY TUB CHRM1 PLCB1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY GRB7 PRKCA PXN GDNF JUN CREB1 MAPK1 PDLIM7 NCK1 DOK4 SHC1 DOK5 PIK3R1 DOK6 SRC SHANK3 GRB10 RAC1 RAP1A PTPN11 MAPK3 CRK PIK3CA MAPK8 GRB2 SOS1 HRAS FRS2 ARHA DOK1 RET IRS1 BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY NFATC2 MAP2K1 PRKCA NFATC1 MAPK3 PRKAR1B PPP3CA PRKAR1A PPP3CC PLCG1 PRKACG CALM1 JUN CREB1 HRAS ADCY1 NFATC4 NFATC3 FOS RAF1 PRKCB RPS6KA3 PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY DOCK1 PXN SPP1 VCAM1 ITGA4 SRC IGSF8 CD81 THBS2 ADAM28 AMICA1 RAC1 ARF6 JAM2 PRKAR1B TLN1 PRKAR1A CRK MYH2 CD14 PTK2B ITGB1 YWHAZ THBS1 MDK BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY PRKCA EIF2S1 TLN1 CASP6 ATM BCL2 BAD CASP9 BAX CASP3 STAT1 PARP1 APAF1 PRKCB BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAP2K1 PRKCA MAPK3 F2 MAPK1 F2RL3 F2R HRAS SYK ITGB1 PTGS1 RAF1 PLCB1 PRKCB BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY PRKCA CCNB1 CDC2 CSK CDC25B VPS16 GRB2 PRKCB PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY SIRT1 EFNA1 EGLN1 EGLN3 VEGFA SP1 APEX1 SLC11A2 CREBBP POU5F1 FLT1 ADORA2A EIF3E FXN EGLN2 KDR VHL ELOC HIF1AN EPO CITED2 MMP14 HEL-S-68p ABCG2 EP300 BHLHB2 TWIST1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY EFNB2 EFNB1 TIAM1 EPHB2 EPHB1 EPHB4 PIK3R1 MAP2K4 BLK SRC ITGB3 YES1 LYN c-fgr FYN MAP3K7 RAC1 PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY BIRC2 BIRC3 IL4 JUN MYC MAPK9 CD40 MAPK14 CD40LG MAP2K4 NFKBIA MAP3K1 MAPK10 RELA TRAF2 TRAF3 MAPK11 TRAF6 JAK3 MAP3K14 C4BPA FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY AKT1S1 PXN CYCS EIF4EBP1 NRAS CCNE1 MAPK1 MAPKAP1 PML RB1CC1 MLST8 RICTOR BRAF KRAS SGK1 FBXW11 CDK2 EEF2K EEF2 TSC2 RPS6KA1 IRS1 DDIT4 PRKCA SFN BNIP3 EIF4A1 PLD2 PPARGC1A HEL2 IKBKB TSC1 RHEB RAC1 EIF4E MAP2K1 MAPK3 PRR5 PDPK1 RRAGA RRAGB MTOR RRAGD RPS6KB1 ULK2 ULK1 RRN3 POLDIP3 EIF4B YWHAQ HEL-S-1 HRAS ARHA MAP2K2 YWHAG YWHAZ YY1 RAF1 RPTOR DEPTOR BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY TNF PRKCA NOS2 NR0B2 NR1H3 NCOA1 JUN SRA1 MED1 NCOR2 RXRA SP1 LPL MAPK1 PDGFA MYC PPARGC1A PIK3R1 NFKBIA NCOR1 RELA ME1 CREBBP MAPK3 PRKAR1B PRKAR1A NR1C1 PRKACG PIK3CA CITED2 HSD17B4 STAT5B MRPL11 DUT APOA2 RB1 FABP1 ACOX1 EHHADH PTGS2 EP300 PRKCB BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C8A CFP C6 C7 HEL-S-62p C9 CFD PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY SIRT1 CCNA2 BAK1 CCNE2 GDF15 PML FAS BAX NTRK1 BCL2L11 MAPK11 BRCA2 CASP2 KAT5 FASN CHEK1 PIN1 ADA RAD51 TP53AIP1 CDC2 CLCA2 FLOT2 CDK2 TP73 AEN TUBA1A TP63 PLK1 S100A2 CCNB1 SFN PLK3 SERPINA1 HEY2 SP1 WWOX WT1 MYC YAP1 MAPK14 BIN1 TP53I3 RELA MDM2 FOXO3A CDK6 JAK1 BBC3 GATA1 JAG2 ITCH RB1 CDKN1A RNF43 UBE4B HAGH PFDN5 FBXO45 PLPP1 GRAMD4 EP300 HSF1 DEDD D4S234E DCP1B AFP RCHY1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY PI4K2A AXIN1 DVL1 DVL2 DVL3 FZD5 GSK3A WNT3A APC CTNNB1 GSK3B STM7 LRP6 PPP2R5A KLHL12 CSNK1G1 NKD2 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPRO PIK3C2B SPRED1 STAP1 SOCS1 BAD SHC1 STAT3 PIK3R1 GSK3B LYN SNAI2 GRB10 SH2B3 FOXO3A TEC CREBBP PTEN GRAP2 MAP2K1 PTPN11 FER MAPK3 CRKL EPOR PDPK1 RPS6KB1 PIK3CA CBL EPO KITLG MAPK8 KIT BCL2 GRB2 SOS1 MATK HRAS MAP2K2 DOK1 STAT1 RAF1 VAV1 SH2B2 PTPN6 MAP4K1 BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY CCL2 TNF CSF1 MST1R IL1B PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY EGFR SH3GL2 HGS ITSN1 UBE2D1 UBE2D2 ZFYVE28 CHMP3 AMPH STAMBP NRAS TSG101 ARHGEF7 PIK3CD LRIG1 PIK3R3 PIK3R2 UBE2D3 SHC1 PIK3R1 SYNJ1 SRC KRAS EPN1 RAB5A CDC42 PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 SPRY2 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY MAPK3 MAPK7 SHC1 PIK3R1 PLCG1 PIK3CA NTRK1 CREB1 RPS6KA1 GRB2 MAPK1 HRAS BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY UBE2I SUMO1 CTBP1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF7B SPP1 MMP9 CTNND1 SDC2 FGFR1 FGF6B JUN FGF8 FGF9 FGF8A MAPK1 FGF23 RUNX2 FGF18 PAK4 FGFR4 FGFR3 BGLAP FGFR2 SHC1 CAMK2A PIK3R1 SRC NCAM1 CDH2 PTPN11 MAPK3 PDPK1 PLAUR PLCG1 PIK3CA CBL FGF7A STAT5B GRB2 SOS1 PTK2B FRS2 MET FOS HGF STAT1 SSH1 RPS6KA1 SPRY2 FGF2 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY GAS2 BIRC2 BIRC3 TNFRSF25 NFKBIA CHUK RELA TRADD TRAF2 RIPK1 MAP3K14 CASP10 NFKB1 CASP6 SPTAN1 TNFSF10 BCL2 CASP9 CASP8 CASP3 LMNA FADD DFFB DFFA APAF1 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY RBL1 NFYA CREB1 NFYB NFYC CEBPA GFI1 CLU FTH1 SFRP1 TMEFF2 CSDE1 TBP TMEM126A ALDH9A1 S100A7 NDRG2 GTF2H2 MXD4 IRF8 CEBPD PTPA CCND1 TSC2 DKK1 SPI1 HDAC1 GADD45A SP1 MAX ID2 MYC HDAC3 DNTT ITGA6 FOXO3A SMAD2 SMAD4 ITGB4 BCL2 ERBB2 CDKN2B CDKN1A CDKN1B ITGB1 BRCA1 COL1A2 EP300 DDIT3 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2C CDKN2A CCNB1 CDC2 RBL1 TFDP1 CDK2 CCNE1 CDKN2B CDK7 RB1 CCNH CDKN1A CDKN1B CDKN2D CCND1 CCND3 CCND2 CDK6 CDK4 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY SH3GLB1 PDGFRA EGFR SH3GLB2 PRKCA EGF MET CSF1R CBL GRB2 PRKCB BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY MAP2K6 SMAD4 TNF NFKB1 NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA CHUK RELA EP300 MAPK11 MAP3K7 IL1B CREBBP CXCL8 MYD88 MAP3K14 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY SPP1 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 ITGAV NPNT JAM2 NID1 PLAUR CSPG4 COL2A1 COL6A1 COL11A2 COL5A2 FGA HEL-S-78p TGFBI VCAM1 VEGFA ITGA4 ITGA2 ITGA1 COL1A1 VTN IGSF8 CD81 ITGA7 THBS2 ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 CD14 LAMC1 F13A1 LAMB3 ITGB1 LAMB2 LAMA1 LAMB1 LAMA3 COL3A1 TNC COL1A2 THBS1 MDK BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY NFATC2 MAP2K3 NFATC1 MAPK14 PRKAR1B PRKAR1A PRKACG IL13 IL4 GATA3 IL5 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY RALBP1 MAP2K1 MAPK3 RALA NFKB1 FOXO4 PIK3CA ARHA HRAS BAD PIK3R1 CASP9 CHUK RELA RAF1 CDC42 RAC1 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY MAP2K1 PTPN11 MAPK3 IGF1 PIK3CA IGF1R JUN MAPK8 GRB2 SOS1 CSNK2A1 HRAS SHC1 PIK3R1 FOS RAF1 IRS1 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAP2K1 PRKCA MAPK3 CRKL PLCG1 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 MAP2K3 MAPK14 SHC1 MAP2K4 MAP3K1 RAF1 RAC1 PRKCB PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY KDM1A UBE2I PAWR RANBP9 XRCC5 MED1 NKX3-1 CARM1 UBA3 PELP1 CDK6 TMPRSS2 KLK3 CDKN2A KDM3A TMF1 TGFB1I1 TGIF1 FHL2 ZMIZ1 PATZ1 APPL1 SVIL KDM4C NCOA6 PIAS1 PTK2B PA2G4 LATS2 VAV3 CTDSP1 MAK CTDSP2 ZNF318 SNURF CTNNB1 CCND1 CMTM2 PRKDC BRCA1 CASP8 CCND3 TCF4 FKBP4 UBE3A RPS6KA3 BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY EGFR MAP2K1 PRKCA MAPK3 CALM1 PAK1 JUN MAPK8 GRB2 MAPK1 SOS1 PTK2B HRAS MAP2K2 SHC1 ATF2 MAP2K4 MAP3K1 AGTR1 RAF1 RAC1 PRKCB BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY PRKCA CCL2 PLCG1 CXCL12 CCL4 CALM1 JUN MAPK8 PTK2B MAPK14 CCR5 FOS CXCR4 PRKCB BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY CDKN1A EPOR NFKBIA NFKB1 GRIN1 RELA EPO HIF1A CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 FKBP1A IL4 IL3 RCAN1 CD40LG IFNG RCAN2 IL2RA CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 NCOA1 IL10 TGIF1 PIAS4 PIAS3 NCOA2 MEF2C TGIF2 TFE3 FOXH1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A RBL1 TFDP1 CREB1 NCOR1 MYOD1 IRF7 ATF3 DLX1 CEBPB HDAC2 CBFB HDAC1 CTBP1 MAX FOXG1 GATA3 FOXO4 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 E2F5 IGHA1 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 SP1 CDK4 SP3 CDK2 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events SOCS3 IL18RAP STAT4 IL12B CCL2 IL12RB1 JAK2 STAT5A NOS2 ITGA3 STAT1 STAT3 IL18 IL19 TYK2 NFKB1 NFKBIA CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 ALOX12B CXCL1 PIK3R1 CD3E TNF MPO RELA SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RAN HDAC1 PIAS2 PIAS1 RANBP2 HDAC4 XPO1 UBE2I SUMO1 MDM2 RANGAP1 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 MAPK1 PIP5K1A PTK2B ITGAV RAC1 MAPK3 VAV3 GSN MAP3K1 SYK CHUK MMP2 MMP9 RHOA MAP3K14 CD44 BCAR1 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA ACVR2B SMAD5 ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 SRC PRKACA IRS1 PIK3CA SHC1 JUN PXN IRS2 RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PRKCA PTPN11 PTK2 DOK1 DOK4 GDNF DOK5 DOK6 MAPK8 RASA1 GRB2 SOS1 MAPK1 SHANK3 CRK RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events TGFB1 COL5A2 COL6A1 COL4A3 COL4A6 SDC1 COL6A3 COL4A5 HPSE PPIB FGFR4 MET FGFR3 PRKACA MAPK1 LAMA5 COL11A1 COL11A2 SDCBP MAPK3 COL1A2 CCL5 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 FGF19 COL4A4 COL7A1 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP PRKCA RASA4 RASA2 NF1 KRAS RIN1 SOS2 CALM3 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events SOCS3 JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 JAK3 MYBL1 JAK1 AKT1 IL13RA1 IL4R ARG1 IL10 GTF3A OPRM1 FCER2 DOK2 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 CBL IL2RG SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 CEBPB MTOR AICDA SELP BCL6 RPS6KB1 IRS1 FES SHC1 PTPN6 CCL26 IRS2 BCL2L1 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K IL2RG MTOR NFKB1 PRKCZ RPS6KB1 PIK3CA SHC1 BCL2L1 SGMS1 FOXO3 UGCG TERT SMPD1 E2F1 IL2 HSP90AA1 RPS6 GAB2 LCK PTPN11 IL2RB BCL2 EIF3A IL2RA CALM3 GRB2 SOS1 MYB RAC1 MYC JAK3 JAK1 AKT1 PIK3R1 RELA SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling VEGFA AFDN TEK JAK2 STAT1 PRKACA IL6 PIK3CA NRAS IL2 IFNG KRAS IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 HRAS GAB1 FRS2 GAB2 LCK PTPN11 IL2RB ARHGAP35 IGF1R KDR IL6R PDGFRB MAP2K1 GRB2 MAP2K2 SOS1 LMO4 IFNGR1 NGF FRS3 IL6ST RAF1 SDC2 PDGFB GNAI3 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 PIK3R1 BDNF NOS3 EGF NTRK3 IGF1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RUNX2 RB1 CAMK2D AR CDKN1B NOTCH1 JAK2 KDM1A MAML2 MAML1 NCOR1 GATA6 MYOD1 TWIST1 STAT3 GATA4 ASCL1 RBPJ GATA1 HIF1A HDAC1 GHR CD4 CTBP1 YY1 HEY1 BGLAP HEY2 RBBP8 HES1 SPEN HES6 TLE1 E2F1 PARP1 GAA ARNT NCOR2 PTF1A RCAN1 NEUROG3 KDR CREBBP MYB EP300 TCF3 NCOA1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB3 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB5 ITGB8 ITGB7 ITGB6 ITGA4 ITGAV ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events PAK1 FZR1 CCNB1 PPP2R1A CLSPN FBXO5 ECT2 BTRC NINL BUB1 CENPU NUDC PPP1R12A BORA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 ROCK2 INCENP RAB1A RHOA ERCC6L BUB1B AURKA CDC14B PPP1CB PPP2CA GOLGA2 CDC20 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 PCNA MRE11 PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF CDK2 RAD50 RAD51 CCNE1 EWSR1 FANCD2 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAI2 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAE GSK3B YWHAB CAMK2A AGAP2 CCND1 YWHAQ STAT5A EPB41L1 CREB1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD SRC TRPV1 YWHAZ PIK3CA SHC1 CAMK4 FOXO3 NRAS HRAS GAB1 KRAS GRB2 SOS1 NGF AKT1 NTRK1 PIK3R1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 TGFB1 IL18RAP STAT4 STAT3 IL18 CD4 JUN CD86 CD80 PRF1 IL18R1 CD3G CD3D MAPK9 FOS TBX21 IL2 IL13 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 IFNG HLA-DRB1 IL2RA CREBBP MAPK8 CD3E AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling BUB1 NDC80 SGO1 KIF20A CUL3 CDCA8 NCAPG INCENP PEBP1 AURKC KLHL13 AURKB RASA1 SMC4 H3-3B CENPA NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 EVI5 NPM1 CBX5 SEPTIN1 NSUN2 PPP2R5D KIF23 RHOA KLHL9 PSMA3 DES AURKA NCL BIRC5 NCAPD2 KIF2C TACC1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events TRIO PAK1 PITPNA WASL NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DCC UNC5B PLCG1 DAPK1 UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAP2K1 MAP2K2 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway GNAI2 CDC42 MAPK1 PLCG1 GNA13 MAPK3 S1PR4 GNAI3 GNAI1 RHOA GNAO1 GNAZ GNA12 S1PR5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PDE3B PIK3CG PIK3R6 MAP2K1 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network ATP2B1 LYZ SMARCA2 HIPK2 KITLG CDKN1B CDK6 CCND1 MYF6 TAB2 TAB1 ADA PTGS2 GATA1 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 MYB SIN3A MYC EP300 PIAS3 CCNB1 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 GATA3 CLTA YEATS4 ETS2 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 BCL2 MAP3K7 PTCRA PAX5 HSPA8 SND1 CCNA1 CREBBP MAF ADORA2B TFEC KIT MCM4 PRTN3 ZFPM1 SKI PPID MAD1L1 COL1A2 BIRC3 SP1 CEBPA CSF1R COPA CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 MPO CBX4 CDKN2A EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling PAK1 WASL ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 GRB7 EFNB3 SRC EPHB2 EPHB1 PIK3CA SHC1 EPHB4 PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 PTK2 KRAS CDC42 RASA1 MAP2K1 GRB2 MAPK1 CRK RAC1 MAPK3 PIK3R1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 SMPD1 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 IKBKG FADD MAP2K7 BID MAP2K6 MAPK8 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 AKT1 SYK CHUK PIK3R1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK2 PLK4 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway TNFRSF1A PRKRA MADD RB1 CYCS BAX NSMAF NFKB1 BAD NFKBIA PRKCZ PRKCD MAP4K4 SMPD1 CASP8 RIPK1 BCL2 FADD BID MAPK8 MAP2K1 MAP2K2 MAPK1 MAPK3 RAF1 MYC BIRC3 ASAH1 TRADD MAP3K1 PDGFA AKT1 SMPD3 BAG4 AIFM1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 TNF EGF EIF2AK2 PAWR RELA TRAF2 IGF1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 PLD2 KLK6 UCHL1 GRK5 SNCA BAD LYN PRKCD SRC TOR1A CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 PTK2B SYK PPP2R5D ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway BTRC MAPK14 NFKB1 NFKBIA SRC SYK PIK3CA BCL3 PIK3R1 REL ARRB2 IKBKB RELA LCK RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway CDKN1B ROCK1 PLD1 PLD2 PPP1R12A PRKCZ JUN FOS SRF PTEN SLC9A1 PARD6A CFL1 ITGB1 PIP5K1B PIP5K1C ROCK2 CCN1 SCAI SH3GL2 ATF2 CDC42 MAP2K6 MAP2K3 MAPK8 LIMK2 LIMK1 RDX MSN PIP5K1A MRTFA MAPK12 CIT EZR DIAPH1 ACTA1 SLC9A3 MYL2 PKN2 PKN1 TLN1 F2RL2 VCL RHOA MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B INS SOCS3 CSK PTPN1 INSR FER FCGR2A JAK2 TRPV6 STAT5A LEP NOX4 SPRY2 LAT STAT3 TYK2 PIK3CA ITGB3 ITGA2B AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B LYN SRC IRS1 SHC1 FGR HCK LCK DOK1 PDGFRB GRB2 CRK PDGFB CSF1R EGFR CSF1 PRL YBX1 CSN2 CDH2 PIK3R1 LEPR CAPN1 EGF PRLR TXN SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events TGFB1 BAX FGFR4 CSF2 CXCL8 FGFR3 TNFRSF13B LAMA1 EPB41 LAMA3 KNG1 RACK1 PRKCD SRC PRKACA EPHB2 CAV2 TRAPPC4 FN1 HRAS CASP3 ITGB1 NF1 MAPK8 RASA1 MAPK1 ITGA2 EZR SDCBP MAPK3 SDC2 FGF23 MMP2 CASK RHOA FGF19 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway KRAS MAP2K1 MAPK1 RAF1 MAPK3 BRAF ELK1 NRAS MAP3K8 PTPN7 HRAS FOS PRKCB PRKCA ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network INS SOCS3 RB1 CCND1 NOS2 CXCL8 IL6 JUNB IL23A JUN POU2F1 HES1 HRK ACHE FOS MAPK9 CSRP2 DUSP10 KAT5 RUVBL2 DUSP5 PDGFRA DUSP1 NF1 DUSP8 IFNG SERPINB5 CUL3 CCNA2 DDIT3 ATF2 JDP2 MACROH2A1 MAPK8 PLAU PPARGC1A TGFB2 MAPK1 JUND MAPK11 COL24A1 HBG2 GADD45A SELE MAPK3 EP300 ARG1 MMP2 CREB1 ATF3 MAPK14 CBFB BCL2L1 TH PRKCA BCL2 BRCA1 ESR1 CDK4 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 LYN SRC PIK3CG PIK3R6 FGR HCK LCK CRK CRKL VAV3 EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 RHOA EFNA1 EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 NFKBIA YY1 PRKACA RANBP2 HDAC4 XPO1 UBE2I SUMO1 NCOR2 RANGAP1 RAN SIN3B SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 SAP30 CHD3 MBD3L2 KAT2B SMG5 PRMT5 SIRT4 BTRC SIRT5 SIRT6 SIRT7 NCOR1 SIRT1 SIRT2 WDR77 SIRT3 PPARG FKBP3 HDAC2 HDAC5 HDAC3 HDAC1 HDAC8 MAX GATA2 HDAC9 NR2C1 HDAC6 HDAC7 MTA2 RBBP4 MBD3 SMURF1 SAP18 MBD2 RBBP7 GATAD2B GATAD2A TFCP2 MXD1 CREBBP SMAD7 ZFPM1 TNF RELA ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events INS ITGA3 PLD1 PLD2 CLTC RALA ITGB1 CTNND1 SLC2A4 PIP5K1C ADRB2 ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 ITGA4 TSHR ITGAV ITGA2 DNM2 ITGA1 NME1 SCAMP2 ACAP1 ITGA10 BIN1 ITGA11 ITGA8 EXOC4 AGTR1 ITGA7 EXOC3 ITGA6 CPE ITGA5 CTNNB1 ITGA9 EXOC6 EXOC5 EXOC2 VAMP3 EXOC1 ARF6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling USP7 YWHAE MST1 CSNK1D YWHAB CSNK1E RBL2 CDKN1B CAT SGK1 YWHAQ CSNK1G2 CSNK1G1 RALB SFN BCL2L11 YWHAG CSNK1A1 YWHAH SOD2 FASLG FBXO32 G6PC1 YWHAZ MAPK9 XPO1 IKBKB RAN MAPK8 MAPK10 GADD45A AKT1 EP300 CHUK CCNB1 KAT2B SIRT1 PLK1 BCL6 FOXO4 FOXO3 FOXO1 RALA CREBBP CDK2 CTNNB1 ZFAND5 SKP2 CSNK1G3 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI2 ABCC1 GNA13 SPHK1 S1PR4 SGPP1 GNAI3 GNA14 GNAI1 GNA15 SGPL1 GNA11 GNAQ S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAE GSK3B YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD SRC PRKACA YWHAZ FOXO4 BCL2L1 FOXO3 FOXO1 GSK3A MAPKAP1 CASP9 HSP90AA1 AKT2 AKT3 MLST8 RICTOR KPNA1 SLC2A4 MAP3K5 TBC1D4 PRKDC CDKN1A RAF1 AKT1 CHUK E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AFDN CCND1 RAP1B SRC PIK3CA RAP1A CTNND1 PIP5K1C CYFIP2 NCKAP1 ITGAE CDC42 CDH1 WASF2 CTNNA1 AP1M1 JUP KLHL20 ITGB7 ENAH TJP1 CRK TIAM1 DLG1 RAC1 NME1 CTTN ABI1 RAPGEF1 AKT1 IQGAP1 VAV2 CTNNB1 RHOA PIK3R1 ARF6 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GAS1 CDON TGFB2 LRPAP1 STIL DHH PIK3CA AKT1 HHIP PTCH1 PTCH2 IHH LRP2 PTHLH GLI2 PIK3R1 HHAT SHH ARRB2 GRK2 SMO BOC POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK2 PLK1 PLK3 PLK4 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 MAP2K7 NCKAP1 ATF2 WASF2 MAP2K6 MAPK8 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 PAK1 NCF1 NCF2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA MAPK14 NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 ABI2 ARPC2 ARPC3 NOXA1 NOX1 PLCB2 MAP3K11 CFL1 PIP5K1B PIP5K1C CDH1 MAP2K3 CTNNA1 LIMK1 CRK IQGAP1 CTNNB1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 GUCY2F RPE65 GRK1 GNGT2 RDH12 GNAT2 RGS9BP GRK7 RDH5 CNGB3 GNB3 PDE6C CNGA3 LRAT GNB5 RGS9 SLC24A2 GUCY2D PDE6H GUCA1B GUCA1A GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF9 DNMBP APC SPATA13 ARHGEF7 ARHGEF6 ARHGDIA PLCG1 ITSN1 CDC42 RACGAP1 NME1 VAV3 BCAR3 DOCK6 ITSN2 ARHGEF25 DOCK9 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network VEGFA FLT1 EPO EPAS1 CITED2 SLC2A1 SIRT1 TWIST1 PGK1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ARNT KDR CREBBP SERPINE1 ETS1 SP1 EP300 EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity GSK3B SMARCA2 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 MDM2 KAT7 SMARCC1 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 MAP2K6 NR2C2 MAPK8 HOXB13 RXRB RXRA SRY NR3C1 RXRG SPDEF SMARCE1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 NCOA1 MAP2K4 NCOA2 KAT2B AR SIRT1 MAPK14 HDAC1 SRC GATA2 NR2C1 HDAC7 FOXO1 REL HSP90AA1 CREBBP CEBPA PKN1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway PDGFRA CAV1 GRB2 SOS1 PLCG1 CRK ITGAV CRKL RAPGEF1 JAK1 CAV3 CSNK2A1 PIK3CA JUN SHC1 SHB SHF ELK1 FOS PIK3R1 SRF SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events AGRP FYN FGFR4 CXCL8 FGFR3 CTTN SRC FGF23 EGFR PSENEN CASK NCAN SDC3 PTN PSEN1 POMC MC4R APH1A FGF19 NCSTN APH1B SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ATF1 GDI1 HSPB1 RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 NOS2 CREB1 EIF4E MEF2A KRT8 PLA2G4A MAPK14 MITF CEBPB USF1 PTGS2 KRT19 MAPKAPK3 MAPKAPK2 MAPKAPK5 HBP1 JUN ATF6 RAB5A SLC9A1 DDIT3 ATF2 PPARGC1A MAPK11 ESR1 TP53 MEF2C ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events DOCK1 SRC PRKACA YWHAZ FN1 PXN IGSF8 CD81 THBS2 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 ITGB1 PTK2 PRKAR1B JAML PRKAR1A PTPRA SPP1 CRK PTK2B ITGA4 RAC1 ABI1 TLN1 BCAR1 GIT1 ARF6 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 FZD4 WNT3A IGFBP4 RYK FZD7 WNT7B FZD6 WNT5A ATP6AP2 WNT1 FZD9 KREMEN1 FZD8 WNT7A KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network CRTC1 DMP1 MT2A GJA1 NPPA CCL2 CDKN1B TIMP1 CCND1 EDN1 HLA-A ELF1 DMTF1 NTS BCL2L11 CSF2 CXCL8 PENK BAG1 EGR1 TCF7L2 AGT FOSL2 HIF1A FABP4 COPS5 IL6 MAFG JUNB TRIP6 JUN FOSB NFATC3 NFATC2 NFATC1 FOS IL2 FOSL1 IL4 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 IL10 MMP9 TGFB1 CREB1 ATF3 CBFB GATA2 TH PTEN CDK1 CCN1 MAF ESR1 IL5 ACTA1 COL1A2 SP1 MMP1 CTNNB1 TP53 CDKN2A IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events PTPN11 JAK2 STAT5A GRB2 STAT5B IL5 SDCBP LYN PIK3CA CISH IL5RA CSF2RB PIK3R1 PIM1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling GSK3B ARHGEF7 ARHGEF6 CCND1 CREB1 PPP1R12A JUN PXN RUVBL1 NCK2 ILKAP XPO1 TNS1 PARP1 GIT2 HSP90AA1 PPP1R14A RUVBL2 PPP1R14B PPP1R14C RICTOR ACTN1 RHOG PARVA PARVB CKAP5 ILK ZEB1 CDC42 PARVG NACA CDC37 SNAI1 TACC3 ZYX ELMO2 MYL9 RAC1 DIAPH1 LIMS2 LIMS1 AKT1 IQGAP1 CTNNB1 AURKA N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events PTPN1 GJA1 FER ROCK1 PLCG1 PIK3CA PTPN11 CTNND1 PIP5K1C LRP5 CALM3 CDC42 MAPK8 CTNNA1 JUP RAC1 CTTN GRIA2 DAGLA GSN MYL2 DCTN1 CNR1 KIF5B CAMK2G AXIN1 CTNNB1 RHOA GAP43 MAPRE1 DAGLB FGFR1 PIK3R1 CDH2 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor MED1 TGFB1 SREBF1 NR1H2 NR1H4 NR1H3 NR4A1 RARA RARB PPARA PPARD PPARG RPS6KB1 NCOR2 BCL2 RXRB VDR RXRA RXRG NCOA1 RARG THRB THRA TNF FAM120B ABCA1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC EP300 CHUK NCOA1 CTSD NCOA2 MED1 NCOR1 COL18A1 CALCOCO1 CD82 MPG CEBPB SRA1 PHB2 DDX17 HDAC1 PDIA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR TRIM59 NCOA7 TFF1 PGR SET ANP32A PRDM15 NEDD8 PCNA C3 MTA1 HSF2 NRIP1 SMAD4 BRCA1 VTLGL1 APBB1 NDUFV3 ATP5PF LMO4 XBP1 KLRC3 ESR1 ABCA3 GREB1 POU4F1 NR0B2 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M PRL ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling TEK STAT5A ELF1 NFKB1 PIK3CA FN1 ELK1 ITGB1 CDKN1A MAPK8 MAPK1 ETS1 RAC1 MAPK3 AKT1 MMP2 ITGA5 DOK2 PAK1 FYN STAT5B PLD2 MAPK14 GRB7 RPS6KB1 FES SHC1 PXN FOXO1 NCK1 PTPN11 PTK2 RASA1 GRB2 CRK AGTR1 FGF2 GRB14 F2 ELF2 PLG ANGPT1 PIK3R1 ANGPT4 ANGPT2 NOS3 TNF BMX TNIP2 RELA DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells IFNA4 IFNA7 IFNA6 STAT4 IFNA2 IFNA8 TNFRSF4 B2M EOMES HLA-A IFNAR2 IFNA13 IFNA14 IFNA16 IFNA17 FASLG TNFRSF18 EGR1 CD8B CD8A PRKCQ IFNA10 IFNAR1 JUNB IFNA21 JUN EGR4 TNFRSF9 BRAF ELK1 GZMB PRF1 NRAS NFATC3 CD3G NFATC2 PTPN7 CD3D NFATC1 FOS MAPK9 IL2 PRKCB FOSL1 PRKCE CD247 IFNG KRAS IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS PRKCA IL2RB MAP2K1 MAP2K2 RAF1 CD3E TNF IFNA5 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 PLCG1 RAP1B PIK3CA JUN BRAF PTPN21 CAPN2 NCK2 SH3GL1 ARHGEF11 MAPK9 RRAS ARHGEF28 ASAP1 GIT2 ARHGAP26 KLF8 ACTN1 ITGB1 ROCK2 MAPK8 ITGB5 MAPK1 ETS1 ITGAV RAC1 RAPGEF1 ITGA5 RHOA MAP2K4 BCAR1 PAK1 WASL FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 PTK2 ARHGAP35 RASA1 MAP2K1 GRB2 SOS1 MAPK8IP3 CRK ACTA1 RAF1 TLN1 VCL PIK3R1 BMX ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMB3 LAMB2 LAMB1 ITGB4 LAMC2 ITGA6 LAMC1 LAMA5 LAMA1 LAMA2 LAMA3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway CENPS RAD9A BTRC FBXW11 HES1 MRE11 H2AX BLM WDR48 BRCA1 FAAP24 BRCA2 BRIP1 NBN CHEK1 TOPBP1 USP1 ATRIP FAAP100 FANCI FANCL RFC5 FANCA RFC3 FANCC RFC4 FANCE FANCM FANCG RMI1 FANCF RFC2 RAD50 XRCC3 TOP3A RPA1 HUS1 FANCD2 RPA2 ATM FANCB PALB2 ATR UBE2T RAD17 RAD1 FAN1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms TOP2A GSK3B RUNX1 YAP1 STXBP4 RRAD NOTCH1 DLX5 DLX6 TBXT SEC14L2 SFN ITGA3 ADA CCNB2 TP63 PERP BDKRB2 HELLS GPX2 TCF7L1 FOSL2 FBXW7 RACK1 IGFBP3 ADRM1 WWP1 HBP1 PPP2R5A NRG1 KRT5 HES1 POU2F2 IL1A ITCH AXL FASN KRT14 RAB38 MDM2 MRE11 BRCA2 VDR CEBPD ATM COL5A1 CDKN2A CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 PARP1 CASP9 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 GSN TRADD MAP3K1 CRADD TRAF2 VIM TNFRSF1A SREBF1 MADD CYCS BAX CASP6 APP NUMA1 LMNB2 LMNB1 PTK2 BCL2 PIDD1 CASP7 SLK CFL2 CASP4 ARHGDIB CASP1 LIMK1 CASP2 OPG199 SPTAN1 DFFB DFFA APAF1 ACTA1 GAS2 TOP1 BIRC3 SATB1 DIABLO XIAP LMNA TFAP2A KRT18 TNF IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity TRIO DEF6 BCR TIAM2 SPATA13 ARHGEF2 DOCK2 ARHGEF7 ARHGEF6 ARHGDIA RASGRF2 KALRN ELMO1 RASGRF1 DOCK1 SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP9 ARHGAP17 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 NGEF CHN1 RALBP1 MCF2 VAV1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling THY1 MST1 SELPLG LRP1 PLAT MST1R HMGB1 ROCK1 AGER ICAM1 CCN2 APOB RAP1B JAM3 PLAUR NFKB1 SELP LPA IL6 HCK RAP1A JAM2 MYH2 ITGAM ITGB2 PLAU TLN1 MMP2 MMP9 RHOA PLG TNF ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 MAPK1 PIP5K1A PLD2 TIAM1 KALRN NME1 RAC1 PLAUR MAPK3 ARF1 RAB11A RAB11FIP3 RHOA ARF6 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells FER PLCG1 LAT NFKB1 SPHK1 PIK3CA ITK JUN WIPF1 CBLB FCER1A S1PR1 FCER1G NFATC2 LAT2 FOS HCLS1 LCP2 PRKCB MS4A2 IKBKB PLPP1 PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 MAPK1 BTK MAPK3 MAP3K1 AKT1 SYK CHUK MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 PAK2 LYN SHC1 PXN HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 PIK3R1 VAV1 RELA S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway GNAI2 VEGFA FLT1 JAK2 GNA13 SRC GNA14 GNA15 GNA11 GNAQ S1PR3 AKT3 CXCR4 PDGFRB MAPK1 RAC1 MAPK3 PDGFB GNAI3 GNAI1 AKT1 RHOA GNAO1 GNAZ GNA12 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling ITGB1 PTK2 MADCAM1 PXN RHOA ITGB7 ITGA4 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG KRAS PRKCI DYNLT1 MATK CDC42 SQSTM1 FAIM SHC2 RGS19 MAPK1 SHC3 TIAM1 MAGED1 NEDD4L RAC1 ABL1 CRKL MAPK3 NGFR RAPGEF1 ARHGAP32 RIT1 RIT2 EHD4 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS GAB1 FRS2 GAB2 PTPN11 RASA1 MAP2K1 GRB2 SOS1 CRK NGF FRS3 NTF4 NTF3 NTRK1 NTRK2 MCF2L PIK3R1 BDNF NTRK3 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events ADAP1 ZAP70 ARF5 FYN INPP5D YES1 SGK1 BLK PLCG1 LAT PDPK1 ARF1 LYN SRC PIK3CG PIK3R6 PIK3CA ITK FGR HCK FOXO3 NRAS RAP1A HRAS PIK3CB HSP90AA1 PTEN LCK KRAS BTK RAC1 SYK INPPL1 DAPP1 RHOA CYTH3 CYTH2 PLCG2 PIK3R1 BLNK CYTH1 ARF6 PLEKHA1 PLEKHA2 ARAP3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events YAP1 ERBB4 ERBB2 FYN LRIG1 JAK2 WWOX STAT5A NRG2 TAB2 CBFA2T3 STAT5B GRIN2B NCOR1 EREG BTC ADAM17 NRG3 NRG4 DLG4 NEDD4 HBEGF WWP1 PIK3CA SHC1 NRG1 ITCH PIK3CB MDM2 GRB2 MAPK1 MAPK3 PRL PIK3R1 PRLR GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events CCL2 INPP5D JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 LYN CSF2RA PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM CISH IRF8 CSF2RB NRAS HRAS FOS IKBKB PRKACB GAB2 PIM1 PTPN11 KRAS MAP2K1 GRB2 MAP2K2 SOS1 MAPK1 MAPK3 RAF1 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta PKN1 MAP2K3 EEF2K CCND1 MAP2K6 MAP3K20 MAPT MAPK13 SNTA1 MAPK12 STMN1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction AFDN ROCK1 MET AQP5 NCK1 AQP3 LPP LIMA1 MYO6 MGAT3 ACTN1 CTNND1 STX4 PIP5K1C VASP PLEKHA7 CYFIP2 IGF1R CAMSAP3 NCKAP1 KIFC3 CDH1 NECTIN2 CTNNA1 ENAH ZYX DIAPH1 ABI1 MYL2 EXOC4 EGFR EXOC3 HGF CTNNB1 VCL RHOA EFNA1 GIT1 ARF6 EGF EPHA2 IGF1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 VEGFA FLT1 ROCK1 PLCG1 PDPK1 ARF1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 CALM3 CDC42 MAP2K6 MAPK1 MAPK11 PTK2B ITGAV MAPK3 AKT1 SHB RHOA CBL CAV1 FYN MAPK14 FBXW11 PAK2 NEDD4 MAPKAPK2 SRC FES PTPN6 PXN GRB10 NCK1 HSP90AA1 GAB1 PRKCA PTPN11 PTK2 KDR MAP2K3 HSP90AB1 CTNNA1 PTPRJ MAP2K1 GRB2 CDH5 MAP2K2 MYOF HGS SH2D2A DNM2 AKAP1 CAMKK2 RAF1 VTN PTPN2 VCL IQGAP1 CTNNB1 PIK3R1 NOS3 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SUPT3H SUPT7L BCAT1 GAPDH PTMA SHMT1 TAF9 ODC1 IREB2 RPL11 SLC2A1 CDCA7 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 HUWE1 KIR3DL1 RUVBL1 EIF2S1 LIN28B GPAM POLR3D FOSL1 ID2 KAT5 RIOX2 RUVBL2 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 SNAI1 MYC NPM1 EP300 MMP9 NCL BIRC5 CCNB1 BAX KAT2A EIF4E HMGA1 MAX TERT HSP90AA1 PIM1 MTA1 SMAD4 CREBBP SMAD3 NBN NME1 EIF4A1 CDK4 TFRC TRRAP ENO1 BMI1 CCND2 PEG10 UBTF RCC1 TK1 TP53 DDX18 ACTL6A CAD NME2 CDC25A REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta PAK1 FYN YES1 BLK TAB1 RALB MAPK14 PAK2 LYN SRC FGR HCK DUSP10 LCK RALA RIPK1 DUSP1 DUSP8 DUSP16 PAK3 PRKG1 CDC42 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAP3K12 MAPK11 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) GSK3B KITLG FER JAK2 EPO STAT5A STAT1 STAT3 PDPK1 BAD PIK3CA MATK MAPK8 PTPRO PIK3C2B SPRED2 SPRED1 GRAP2 CRKL MAP4K1 MAPK3 STAP1 SH2B3 SH2B2 AKT1 EPOR TEC SNAI2 CBL SOCS1 MITF LYN RPS6KB1 SHC1 PTPN6 FOXO3 GRB10 HRAS GAB1 PTEN PTPN11 BCL2 DOK1 CREBBP MAP2K1 GRB2 MAP2K2 SOS1 KIT RAF1 PIK3R1 VAV1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 MAPK8 GPC3 FURIN MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events VEGFD VEGFA ADAM2 ADAM15 ADAM12 ADAM8 PAOX NOS2 CSF2 SRC CSF2RA FN1 PXN VCAM1 ITGB1 SPP1 RAC1 ITGA9 TNC BCAR1 F13A1 SAT1 TGM2 KCNJ15 VEGFC DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining PRKDC DCLRE1C XRCC4 POLM PNKP LIG4 DNTT XRCC6 APTX XRCC5 APLF POLL NHEJ1 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) PTPN1 APC MET PLCG1 EGR1 RAP1B PDPK1 BAD PRKCZ PIK3CA JUN NCK2 AKT2 MLST8 PRKCI CDC42 MAPK8 SNAI1 MAPK1 ETS1 RAC1 CRKL MAPK3 RAPGEF1 MAP3K1 AKT1 INPPL1 RHOA MAP2K4 BCAR1 PAK1 WASL CBL INPP5D EIF4EBP1 EIF4E MTOR SH3KBP1 PAK2 RPTOR DEPTOR SRC AKT1S1 NUMB SHC1 ARHGEF4 PXN RAB5A RIN2 KPNB1 RAP1A EPS15 HRAS PAK4 RANBP9 NCK1 RANBP10 GAB1 MUC20 GAB2 PARD6A PTPN11 PTK2 SH3GL2 CDH1 CTNNA1 PTPRJ MAP2K1 GRB2 MAP2K2 SOS1 HGS CRK RAF1 PTPN2 HGF F2RL2 CTNNB1 PIK3R1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway PAK1 WASL PTPN1 PLCG1 STAT1 STAT3 SRC PIK3CA SHC1 PTPN6 NRAS NCK2 HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 PIP5K1C KRAS RASA1 GRB2 SOS1 MAPK1 MAPK3 GSN GNAI3 GNAI1 EGFR TLN1 PIK3R1 EGF PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events GNAI2 ARHGDIA ROCK1 GNA13 PRKCD GNA14 GNA15 PIK3CA GNA11 GNAQ DNM1 PLCB2 PRKCB ARRB1 AKAP13 GRK3 PRKCA SNX1 SNX2 GNG2 VASP ROCK2 PRKCG TRPC6 F2R PLCB3 GNB1 ARHGEF1 PLCB1 ZYX DNM2 MYL2 GNAI3 GNAI1 PKN1 F2RL2 RHOA F2 PIK3R1 NOS3 GNAO1 GNAZ GNA12 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events ADAM12 TNFRSF13B LAMA1 LAMA3 PRKCD FN1 THBS1 MDK PRKCA ACTN1 ITGB1 PTK2 CXCR4 SDC4 TFPI FGF6 NUDT16L1 DNM2 RAC1 CXCL12 SDCBP CCL5 FZD7 GIPC1 ITGA5 FGF2 MMP9 RHOA F2 TNC PLG FGFR1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway USP7 SMYD2 E4F1 GSK3B CSNK1D TTC5 CSNK1E HIPK2 CCNG1 PIN1 MDM4 CSNK1G2 CSNK1G1 RPL11 CSNK1A1 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 CHEK1 ABL1 AKT1 EP300 PPP2CA KAT2B PRMT5 MAPK14 TRIM28 NEDD8 CREBBP RPL5 DYRK2 CSE1L SETD7 UBE2D1 CDK2 TP53AIP1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A ATM DAXX TP53 RPL23 ATR FBXO11 PPM1D SKP2 PTPA CSNK1G3 COP1 CDKN2A CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes PTPN1 DGKA SLC3A2 IKZF1 PTPRK BCE1 EGR2 CSF2 CXCL8 CTLA4 CREM GBP3 FASLG EGR1 EGR3 FOXP3 PPARG PTGS2 RNF128 PRKCQ JUNB JUN EGR4 GATA3 BATF3 CBLB POU2F1 NFATC3 NFATC2 NFATC1 ITCH FOS TBX21 E2F1 IL2 FOSL1 IL4 IL3 CASP3 CD40LG IFNG IL2RA CALM3 MAF IL5 CDK4 IRF4 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway GNAI2 PAK1 MAPK8 CDH5 MAPK1 MAPK14 RAC1 GNA13 MAPK3 GNAI3 GNA14 IRS1 GNAI1 GNA15 JUN GNA11 ELK1 GNAQ RHOA S1PR2 FOS GNAO1 GNAZ GNA12 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling GNAI2 AR CREB1 PLCG1 PELP1 GNRH1 SRC SHBG PIK3CA HRAS PLCB2 FOS PTK2 GNG2 CDC42 PLCB3 GNB1 MAP2K1 MAP2K2 PLCB1 MAPK1 RAC1 MAPK3 RAF1 GNAI3 GNAI1 AKT1 PLCG2 PIK3R1 GNAO1 GNAZ PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CDC25C PLK3 CCNE1 CHEK2 TP53 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 GJA1 CCL2 CCND1 DMTF1 CXCL8 LAMA3 PLAUR FOSL2 IL6 TXLNG JUNB THBD BGLAP JUN HMOX1 LIF NFATC3 USF2 NFATC2 DCN NFATC1 MGP IVL ATF4 FOSL1 ITGB4 CCNA2 PLAU JUND COL1A2 SP1 EP300 MMP1 MMP2 MMP9 NOS3 CDKN2A ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway RAD9A YWHAB DCLRE1C XRCC4 CDC25C CTBP1 RBBP8 TRIM28 MDC1 ABRAXAS1 KAT5 RNF8 MDM2 SMC3 UIMC1 TP53BP1 SMC1A MRE11 TERF2 H2AX UBE2N BLM BID BRCA1 NBN ABL1 RAD50 TOP3A CHEK2 FANCD2 ATM RAD17 COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha TNFRSF1A CYCS FASLG NFKB1 NFKBIA CASP9 CASP6 CASP8 CASP3 RIPK1 BCL2 CD247 MAP3K5 CASP7 FADD MAP2K7 nef BID TRAF1 MAPK8 CFLAR CASP2 FAS APAF1 BIRC3 TRADD CHUK BAG4 MAP3K14 DAXX CRADD TNF RELA TRAF2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HMGB1 HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 TLR4 CHUK S100A9 TLR3 S100A8 RHOA MYD88 TLR2 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events TGFB1 STAT4 IL12B IL12RB1 JAK2 STAT5A STAT1 STAT3 IL18 TYK2 IL6 GATA3 IL1B IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A TNF IL12RB2 STAT2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling YWHAE BCL2L11 BAD PRKCZ PIK3CA MAPK9 CASP9 IKBKB CASP3 IKBKG PRKCI TRAF6 SQSTM1 MAPK8 IRAK1 MAPK10 MAGED1 RAC1 BIRC2 NGFR AKT1 CHUK PSENEN RHOA MYD88 FURIN PSEN1 APH1A NCSTN PRDM4 APH1B SMPD2 RIPK2 NSMCE3 MMP3 CYCS OMG RHOC RHOB MAG ARHGDIA BEX3 MAGEH1 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 E2F1 CASP6 PRKACB APP NGF APAF1 BIRC3 DIABLO MMP7 XIAP NTF4 NTF3 NTRK1 TP53 PLG PIK3R1 BDNF CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway PIP5K1B GSK3B CAV1 APC CUL3 LRP6 CSNK1G1 FZD5 RANBP3 WNT3A KLHL12 NKD2 DVL1 PPP2R5A DVL2 DVL3 AXIN1 CTNNB1 PI4K2A GSK3A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway RUNX2 CBL CAMK2A STAT5B SPRY2 FGFR4 PLCG1 STAT1 FGFR3 PDPK1 PLAUR SRC PIK3CA SHC1 BGLAP JUN KLB FGF1 RPS6KA1 PAK4 NCAM1 FOS IL17RD GAB1 SSH1 FRS2 FGFR2 PTPN11 CTNND1 CDH1 PLAU GRB2 SPP1 SOS1 MAPK1 PTK2B CTTN MAPK3 SDC2 FGF23 AKT1 MMP9 FGFR1 PIK3R1 CDH2 FGF19 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events BMP7 SMAD9 SMAD4 SMAD5 BMPR2 TLX2 FKBP1A ACVR1 AMHR2 SMAD1 AMH COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 PIAS1 TMPRSS2 KLK3 KLK2 PTK2B VAV3 GSN CARM1 AKT1 TGIF1 PIAS4 PIAS3 NCOA2 PAWR MED1 AR RANBP9 SRF HIP1 TGFB1I1 FHL2 UBE3A PRKDC RPS6KA3 NRIP1 BRCA1 CCND3 ZMIZ1 NKX3-1 APPL1 NCOA6 NCOA4 LATS2 XRCC6 CTDSP1 XRCC5 CTDSP2 MAK ZNF318 SNURF FKBP4 KDM3A UBA3 TMF1 PRDX1 HNRNPA1 CTNNB1 PATZ1 SVIL KDM4C PA2G4 TCF4 CMTM2 CDKN2A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes CTNND1 VASP FYN CDH1 CTNNA1 JUP PLCG1 ZYX PIP5K1A RAC1 SRC PIK3CA AKT1 EGFR CTNNB1 RHOA PIK3R1 CASR AKT2 FMN1 AJUBA IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events CRP SOCS3 HSP90B1 TNFSF11 LBP A2M TIMP1 MCL1 JAK2 FGG PTPRE STAT1 STAT3 MAPK14 MITF CEBPB TYK2 PRKCD IL6 JUNB PIK3CA JUN HCK BCL2L1 FOXO1 FOS GAB1 GAB2 IRF1 PTPN11 PIAS1 IL6R MAP2K6 GRB2 SOS1 LMO4 MAPK11 RAC1 IL6ST MYC JAK1 AKT1 CEBPD MAP2K4 PIAS3 PIK3R1 VAV1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EFNA5 EPHA3 EPHA2 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway RAD9A YWHAB PPP2R1A CLSPN BTRC SMARCAL1 MCM7 CEP164 TIPIN CDC6 PPP2R2B FBXW11 TIMELESS MCM2 PLK1 CDC25C YWHAZ MDM2 CCNA2 BRCA2 NBN CHEK1 TOPBP1 ATRIP RFC5 RFC3 RFC4 CDK2 RFC2 RAD51 RPA1 HUS1 FANCD2 RPA2 ATR PPP2CA RAD17 RAD1 CDC25A DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin GSK3B CSNK1D APC CSNK1E LRP6 BTRC CSNK1A1 FZD5 CUL1 WNT3A SKP1 DVL1 DVL2 DVL3 AXIN1 CTNNB1 AXIN2 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE PTPN1 PDPK1 BAD PRKCZ RACK1 PRKCD RPS6KB1 PRKD1 IRS1 YWHAZ PIK3CA SHC1 PXN IRS2 GRB10 NCK2 HRAS PTPN11 PTK2 IGF1R GRB2 SOS1 CRK CRKL RAF1 AKT1 BCAR1 PIK3R1 IGF1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CALM3 MAP2K3 MAP2K6 MAP2K1 CASP1 MAP2K2 MAPK1 IL18 MAPK3 cya ANTXR2 lef IL1B ANTXR1 DEFA1B NLRP1 MAP2K4 pagA TNF PGR VCAM1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods PDE6B GUCY2F GNAT1 RPE65 PDE6A GRK1 CNGB1 RDH12 RGS9BP GNB1 RDH5 LRAT GNB5 RGS9 SLC24A1 GUCY2D PDE6G GNGT1 GUCA1B RHO GUCA1A SAG GUCA1C CNGA1 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network GAS1 CCNB1 RB1 CCND1 CCNB2 PLK1 CDC25B NFATC3 GSK3A FOS ETV5 CDK1 LAMA4 CCNA2 ONECUT1 TGFA CREBBP FOXM1 AURKB BRCA2 CENPB MAP2K1 CENPA CKS1B NEK2 H2BC1 ESR1 XRCC1 CENPF HSPA1B MYC SP1 CDK4 CDK2 EP300 MMP2 CCNE1 CHEK2 BIRC5 SKP2 CDKN2A IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GNAI2 CBL PLD1 CXCL8 PDPK1 LYN PIK3CG GNA14 PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCE PRKCA GNG2 PRKCG PLCB3 GNB1 PLCB1 CXCR1 AKT1 ARRB2 GRK2 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions THY1 FCGR2A FGG PLAT ICAM1 JAM3 PLAUR KNG1 VCAM1 CD40LG ITGAM C3 CCN1 ITGB2 ITGAL PLAU ITGAX ITGAD SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA F10 GP1BA PROC TGFBI INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport INS RHOQ YWHAE VAMP2 GSK3B YWHAB INSR STXBP4 YWHAQ SFN YWHAG YWHAH PRKCZ YWHAZ AKT2 STX4 SLC2A4 TBC1D4 PRKCI CALM3 PPP1CC AKT1 ASIP PPP1R3A GYS1 LNPEP TRIP10 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAE CSK PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ JUN BRAF ELK1 NRAS FOS MAPK9 PRKCE KRAS JUND MYC VAV2 USP6NL WASL CBL SLA ACTN4 FYN RAB4A YES1 DOCK4 MYOCD ARAP1 STAT5B ACTA2 TAGLN NHERF2 PLA2G4A NHERF1 SIPA1 PIK3CG PIK3R6 RAB5A LCK ARHGAP35 PDGFRB MAP2K1 MAP2K2 DNM2 RAF1 PDGFB IQGAP1 PAG1 EPS8 PIK3R1 AFDN PIN1 JAK2 LRP1 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA S1PR1 NCK2 PIK3CB CYFIP2 MAP2K7 ITGB3 NCKAP1 WASF2 MAPK8 MAPK10 MAPK1 ITGAV ABL1 RAC1 CTTN MAPK3 ABI1 RAPGEF1 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 PPP2CA PAK1 PPP2R1A ARPC1B BRK1 BLK ARHGDIA ACTR3 ACTR2 LYN ARPC4 ARPC5 SRC BAIAP2 SHC1 ARPC2 FGR ARPC3 HCK RAP1A GRB10 HRAS NCK1 GAB1 SRF PTEN PRKCA PTPN11 DOK1 RPS6KA3 RASA1 GRB2 PTPRJ SOS1 CRK PTPN2 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 FKBP1A ACVR1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway AFDN PTPRM RAP1B PVR CLDN1 NECTIN3 SRC NECTIN1 PIK3CA RAP1A PTK2 PIP5K1C ITGB3 CDC42 CDH1 NECTIN2 CTNNA1 PDGFRB CRK ITGAV RAC1 RAPGEF1 PDGFB F11R TLN1 IQGAP1 VAV2 CTNNB1 PIK3R1 FARP2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway CSK PDPK1 NFKB1 NFKBIA PIK3CA JUN ELK1 NFATC1 FOS IKBKB FCGR2B IKBKG CALM3 TRAF6 MAPK8 MAPK1 ETS1 BTK RAC1 MAP4K1 MAPK3 MAP3K1 AKT1 SYK CHUK CAMK2G VAV2 DAPP1 PLCG2 BLNK INPP5D MAPK14 LYN PPP3CB CSNK2A1 PPP3CC SHC1 PTPN6 CARD11 BCL2A1 BCL10 POU2F2 MALT1 PPP3CA HRAS CD79B CD79A CD19 SH3BP5 PTEN CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RASA1 MAP2K1 GRB2 SOS1 RAF1 PAG1 PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity TRIO DEF6 BCR ARHGEF2 CDKN1B ECT2 ARHGAP5 ARHGDIA ARAP1 ARHGEF11 ARHGEF28 AKAP13 ARHGAP8 ARHGDIG ARHGAP35 ARHGEF10L ARHGAP6 ARHGAP4 OPHN1 ARHGDIB SRGAP1 ARHGEF1 FARP1 ARHGEF10 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B VAV3 NET1 OBSCN DLC1 ARHGEF3 ARHGEF25 ARHGEF15 ARHGEF5 VAV2 ARHGAP9 RHOA ABR MCF2L NGEF MCF2 ARAP3 VAV1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin botB RAB3GAP2 VAMP2 STX1A UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway DNER ADAM10 NOTCH2 CCND1 NOTCH3 NOTCH1 KDM1A MYCBP MAML2 NOTCH4 MAML1 DTX1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 YY1 RAB11A MIB1 MFAP5 NEURL1 MFAP2 RBBP8 CNTN1 DNM1 LNX1 SPEN NCOR2 IL4 CDKN1A MYC EP300 PSENEN FURIN APH1A NCSTN APH1B CBL ADAM12 BTRC NCOR1 FBXW7 HDAC1 CTBP1 NUMB GATA3 EPS15 ITCH PTCRA ENO1 SKP2 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 IL2RG CDK6 STAT5A ELF1 STAT5B FASLG FOXP3 PIK3CA SHC1 BCL2L1 PRF1 IL2 GAB2 IL4 LCK PTPN11 IL2RB BCL2 CCNA2 IL2RA CCND3 GRB2 SOS1 MYC JAK3 SP1 JAK1 CCND2 PIK3R1 LTA ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events ERBB2 JAK2 NRG2 STAT3 MTOR BAD SRC PRKACA PPP3CB PIK3CA SHC1 JUN NRG1 NRAS DOCK7 HRAS MAPK9 ERBB3 FOS CHRNE PIK3CB USP8 NFATC4 RNF41 NF2 PTPN11 KRAS CDC42 MAPK8 MAP2K1 GRB2 MAP2K2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 RAF1 AKT1 CHRNA1 PIK3R1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events GNAI2 CBL PPP2R1A DOCK2 CXCL8 PLD2 ELMO1 PDPK1 LYN PIK3CG GNA14 RAB11A PIK3R6 GNA15 FGR RAB5A HCK DNM1 PLCB2 PRKCB ARRB1 PRKCA CXCR2 RAC2 GNG2 VASP RAB7A PRKCG PLCB3 GNB1 PLCB1 AKT1 ARRB2 PPP2CA FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions VEGFA THY1 COL4A3 COL4A6 SDC1 FGG COL4A5 HMGB1 TGFBR2 PVR PLAUR SPHK1 FN1 THBS1 LAMB1 CCN1 LAMA4 ITGB3 ITGA2B KDR IBSP EDIL3 PDGFRB PLAU L1CAM SPP1 PECAM1 SDC4 CD47 LAMC1 FBN1 ITGAV VTN COL1A2 PDGFB F11R FGB FGA COL1A1 TNC TGFBI COL4A1 COL4A4 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events SOCS3 STAT5A STAT1 STAT3 PIK3CA JUN CISH NRAS FOS MAPK9 IL2 PRKCB PRKCE IFNG KRAS IL2RA MAPK8 MAPK1 MAPK11 IKZF3 PTK2B STAM2 SOCS2 MAPK3 STAM MYC JAK3 JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS GAB2 LCK PTPN11 IL2RB BCL2 RASA1 MAP2K1 GRB2 MAP2K2 SOS1 RAF1 CDK2 PIK3R1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC1 GPC3 GPC2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E CHEK1 TIMELESS NONO NR1D1 NPAS2 PER2 DELEC1 PER1 CRY2 BHLHE40 CRY1 WDR5 BMAL1 CLOCK ATR IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP STAT4 IL12B IL12RB1 JAK2 B2M EOMES HLA-A STAT5A NOS2 STAT1 STAT3 IL18 FASLG TYK2 CD8B CD8A NFKB1 CD4 IL1B GZMB IL18R1 CD3G CD3D FOS TBX21 IL2 IL4 HLA-DRA CD247 IFNG RAB7A HLA-DRB1 IL2RA ATF2 MAP2K6 IL12A CCR5 SPHK2 IL1R1 IL12RB2 RELB HLX CCL4 RIPK2 CCL3 GADD45B IL2RG GZMA SOCS1 NFKB2 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions MADCAM1 CCN1 SDC1 EDIL3 PLAU ITGB5 TGFBR1 ITGB8 ITGB7 ITGB6 FBN1 ITGA4 ITGAV PLAUR VTN FN1 VCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis VEGFA COL5A2 COL6A1 COL4A3 COL4A6 SDC1 CDKN1B COL6A3 COL4A5 ROCK1 PIK3CA FN1 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 F11R RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 TGFBR2 PI4KA PI4KB SRC RPS6KB1 IRS1 PXN HSP90AA1 PTPN11 PTK2 IGF1R KDR COL11A1 COL11A2 VTN COL1A2 CSF1R TLN1 FGF2 VCL CSF1 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 PIK3R1 COL6A2 COL4A4 IGF1 COL7A1 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B BAX SIRT7 SIRT1 MYOD1 SIRT2 ACSS2 HOXA10 SIRT3 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 FOXO1 HDAC4 FHL2 CREBBP CDKN1A PPARGC1A XRCC6 EP300 TP53 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B RARA RARB MAPK14 HDAC3 HDAC1 PRKACA NCOA3 CCNH CDK7 RBP1 MNAT1 CDK1 NCOR2 PRKCA PRKCG NRIP1 CREBBP MAPK8 RXRB VDR RXRA MAPK1 RXRG MAPK3 AKT1 EP300 NCOA1 NCOA2 RARG HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 TP53 HIF3A HSP90AA1 RBX1 ARNT OS9 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network INS AR CDKN1B COL18A1 APOB CEBPB DSCAM JUN NCOA3 AP1B1 POU2F1 FOS TFF1 SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NR2F2 FOXA3 NRIP1 PISD FOXA2 BRCA1 CREBBP NFIA NFIB NDUFV3 NKX3-1 NFIC ATP5PF SCGB1A1 XBP1 ESR1 VTN SP1 SFTPA1 SOD1 EP300 SHH NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 CSNK1A1 PPARG PRKCZ DVL1 DVL2 DVL3 NFATC2 MAPK9 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 FLNA CTHRC1 SETDB1 DAAM1 RAC1 FZD2 FZD5 FZD7 FZD6 NLK WNT5A RHOA ARRB2 ROR2 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAI2 GNA13 PELP1 HBEGF SRC GNA14 GNA15 PIK3CA SHC1 GNA11 GNAQ NRAS HRAS PLCB2 GNG2 KRAS ROCK2 IGF1R PLCB3 GNB1 GRB2 PLCB1 SOS1 MSN MAPK11 ESR1 GNAL STRN ESR2 GNAI3 GNAI1 AKT1 MMP2 MMP9 RHOA BCAR1 PIK3R1 NOS3 GNAO1 GNAZ IGF1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription MT-CO2 YWHAE TNIK TCF7 APC YWHAB ADCY7 CACNA1G IGF2BP1 CCND1 TBL1X YWHAQ CDX4 CDX1 SFN KCNIP4 KLF4 CXCL8 YWHAG SMARCA4 YWHAH BCL9 TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ JUN CAMK4 TLE1 XPO1 ID2 RUVBL2 INCENP VCAN MYC EP300 MMP2 SNAI2 MMP9 NCOA2 AR BTRC TBXT MITF HDAC2 TCF7L1 HDAC1 CTBP1 HBP1 DVL3 AXIN2 TERT CCN1 CDH1 ZCCHC12 CHD8 CBY1 TRRAP FGF4 MED12 SALL4 LEF1 CCND2 PITX2 CTNNB1 MYOG TLE4 TLE2 KRT1 CTNNBIP1 TCF4 TLE5 DKK4 DKK1 MDFIC TBL1XR1 CDKN2A EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway SOCS3 CBL INPP5D JAK2 EPO STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 IRS2 BCL2L1 RAP1A HRAS GAB1 PTPN11 BCL2 MAPK8 GRB2 SOS1 BTK CRKL RAPGEF1 SH2B3 EPOR TEC VAV2 PLCG2 PIK3R1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45B GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K7 MAP3K5 CALM3 MAP2K6 MAP2K3 MAP3K3 TRAF6 CCM2 MAPK11 GADD45A RAC1 MAP3K1 ATM TXN TRAF2 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway SUPT3H SUPT7L GSK3B PIN1 KAT2A TAF9 PAK2 FBXW7 MAX TAF12 HBP1 PPP2R5A TAF10 PML RUVBL1 KAT5 RUVBL2 ZBTB17 MYC TRRAP AXIN1 ACTL6A PPP2CA SKP2 CDKN2A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway VEGFA GNAI2 KDR PDGFRB MAPK1 PLCG1 RAC1 ABCC1 PTGS2 MAPK3 SPHK1 PDGFB GNAI3 GNAI1 RHOA S1PR1 PLCB2 GNAO1 GNAZ GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network TGFB1 VEGFA TGFB3 FYN YES1 FLT1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC NRG1 FGR HCK SERPINC1 SLIT2 PRNP PLA2G2A CRIPTO APP LCK SMAD2 GPC1 FGF2 FGFR1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins GNAI2 ADCY7 JAK2 EDN1 PRKCQ PRKCD GNA14 GNA15 JUN GNA11 GNAQ FOS EDNRA PRKCB CYSLTR1 PRKCE EDNRB CYSLTR2 EDN2 PRKCH EDN3 ADCY9 ADCY4 ADCY3 ADCY2 CDC42 ADCY1 MAPK8 ADCY8 ADCY6 ADCY5 MAPK1 PTK2B RAC1 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 SLC9A1 PRKCA PRKCG TRPC6 PLCB3 MAP2K1 MAP2K2 PLCB1 CRK GNAL RAF1 COL1A2 SLC9A3 GNAI3 GNAI1 MMP1 COL3A1 GNAO1 GNAZ GNA12 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network VEGFD VEGFA KDR FLT1 NRP1 NRP2 FLT4 VEGFB VEGFC PGF NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte WASL FYN PLCG1 BAD PRKCZ PIK3CA JUN NCK2 MAPK9 NCK1 PIK3CB PARD6A PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 AKT1 NPHS2 F2RL2 MAP2K4 PIK3R1 ARRB2 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events GNAI2 GSK3B ADCY7 PLCG1 CXCL8 NFKB1 NFKBIA PRKCD PRKD1 GNA14 GNA15 TRIP6 JUN GNA11 GNAQ FOS PIK3CB PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 TIAM1 PTK2B RAC1 AKT1 ADRA1B MMP2 LPAR1 MMP9 LPAR2 RHOA LPAR3 LPAR4 BCAR1 NHERF2 PLD2 GNA13 HBEGF LYN SRC PXN MAPT HRAS GAB1 PTK2 GNG2 PLCB3 GNB1 ARHGEF1 CRK GNAI3 GNAI1 EGFR PIK3R1 GNAO1 GNAZ GNA12 RELA BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions VEGFA COL5A2 COL6A1 COL4A3 COL4A6 COL6A3 FGG COL4A5 ITGA3 LAMA1 PLAUR LAMA3 FN1 LAMA2 LAMB3 ITGB1 LAMB2 LAMB1 LAMC2 LAMA4 PLAU SPP1 LAMC1 FBN1 ITGA4 ITGAV ITGA2 ITGA1 ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 FGB ITGA5 FGA ITGA9 NPNT TNC NID1 TGFBI F13A1 CSPG4 TGM2 COL18A1 IGSF8 CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 LAMA5 COL11A1 COL11A2 VTN COL1A2 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL6A2 COL4A4 COL7A1 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling VLDLR TGFB1 PDGFD CTSG MMP3 MMP12 MMP13 CTRC LRP1 FGG GPLD1 ITGA3 DOCK1 PLAUR SRC FN1 ITGB1 ITGAM ITGB3 ITGB2 PDGFRB PLAU ITGB5 SERPINE1 CRK ITGAV RAC1 VTN EGFR FGB HGF ITGA5 FGA MMP9 PLG ELANE NCL BCAR1 FPR1 KLK4 FPR3 FPR2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 ITGB1 ITGB4 DDIT3 CDKN1A CFLAR SPI1 GADD45A MYC EP300 ITGA6 ERBB2 RBL1 GFI1 CLU CREB1 FTH1 HMGCS2 TBP DNTT SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 HDAC3 HDAC1 TMEM126A S100A7 MAX ALDH9A1 IRF8 NDRG2 NDRG1 FOXO3 ZFP36L1 NFYA NFYB NFYC GTF2H2 SFXN3 MXD4 TJP2 BCL2 SMAD2 ZBTB17 SMAD4 BRCA1 PDGFRB CDKN2B SMAD3 COL1A2 CCL5 SP1 CEBPA CEBPD WNT5A DKK1 PTPA ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network ERBB4 ERBB2 TGFA NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR NRG1 ERBB3 HSP90AA1 EGF AREG SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II HDAC11 YWHAE YWHAB TUBA1B GATA1 HDAC5 HDAC3 BCL6 GATA2 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 RANBP2 HDAC4 XPO1 SRF HSP90AA1 UBE2I SUMO1 NCOR2 RANGAP1 RFXANK RAN BCOR GNG2 ANKRA2 GNB1 ESR1 NR3C1 MEF2C GRK2 HDAC10 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 CCN2 PDPK1 PML FKBP1A NEDD4L AXIN1 EIF2A ARRB2 PPP2CA TGFB1 TGFB3 CAV1 YAP1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 WWP1 SHC1 ITCH SMURF1 PARD6A MAP3K7 SMAD2 ZFYVE9 PPP2R2A DACT2 SMAD4 RNF111 TGFBR3 ZFYVE16 SMAD3 GRB2 STRAP SOS1 PPP1R15A TGFBRAP1 PPP2CB SMAD7 SPTBN1 SMURF2 DAB2 OCLN BAMBI DYNLRB1 XIAP CTNNB1 DAXX ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions CDH1 ITGAE ITGB7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K7 MAPK8 LAT CRK GRAP2 MAP4K1 CRKL MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ SFN YWHAG CSNK1A1 YWHAH AKAP5 CABIN1 PRKCQ BAD CHP1 PRKCD PRKCZ PRKACA YWHAZ CAMK4 MAP3K8 NFATC3 NFATC2 NFATC1 MAPK9 XPO1 PRKCB PRKCE FKBP1A CASP3 RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 BAX NR4A1 MAPK14 MEF2D CSNK2A1 BCL2L1 KPNB1 PIM1 PRKCA BCL2 PRKCG CREBBP KPNA2 NUP214 FKBP8 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells CSK TRPV6 PLCG1 LAT PDPK1 PRKCQ RASGRP2 CD4 RASGRP1 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 IKBKG KRAS HLA-DRB1 CDC42 TRAF6 GRAP2 MAP4K1 AKT1 CHUK MAP3K14 ZAP70 CBL FYN INPP5D SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS NCK1 PTEN GAB2 PRKCA LCK PTPRC PTPN11 GRB2 SOS1 FLNA DBNL SLA2 PAG1 RASSF5 STIM1 ORAI1 WAS CD3E STK39 SH3BP2 FYB1 VAV1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals VEGFA CBL CAV1 FLT1 PLCG1 PDPK1 HIF1A PRKACA PIK3CA NCK1 HSP90AA1 PRKCB PRKCA PTPN11 CALM3 RASA1 SHC2 MAPK1 NRP1 NRP2 VEGFB MAPK3 PGF CD2AP AKT1 PIK3R1 NOS3 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events SHC1 EGFR EDN1 GRB2 SOS1 HRAS EDNRA EGF MTOR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins GLI1 GNAI2 GLI3 SAP30 GSK3B STK36 CSNK1D KIF3A CSNK1E RAB23 SUFU SPOP BTRC MTSS1 CSNK1G2 IFT88 CSNK1G1 CSNK1A1 FBXW11 HDAC2 HDAC1 PRKCD PRKACA LGALS3 RBBP4 XPO1 SAP18 RBBP7 GNG2 PIAS1 FOXA2 CREBBP GNB1 MAP2K1 SIN3B SIN3A GNAI3 GNAI1 AKT1 PTCH1 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 CSNK1G3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway INS RHOQ CBL PTPN1 CAV1 INSR INPP5D SGK1 EIF4EBP1 SORBS1 PDPK1 PRKCZ RPS6KB1 IRS1 PIK3CA SHC1 FOXO3 GRB10 NCK2 HRAS NCK1 AKT2 PARD6A PTPN11 DOK1 PRKCI PTPRA RASA1 GRB2 EXOC7 SOS1 CRK RAPGEF1 SH2B2 EXOC4 AKT1 EXOC3 F2RL2 GRB14 EXOC6 EXOC5 EXOC2 PIK3R1 EXOC1 TRIP10 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRA PDGFD PDGFB PDGFA PDGFRB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling PAK1 PTK2 CBL ARHGAP35 GRB2 ACP1 TIAM1 RAC1 VAV3 SRC PIK3CA SHC1 INPPL1 VAV2 RHOA EFNA1 BCAR1 PIK3R1 EPHA2 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ JUN BRAF ELK1 NRAS CAPN2 FOS MAPK9 DUSP1 KRAS RIN1 CALM3 ATF2 PEBP1 AKT1 VAV2 MEF2C ATF1 USP6NL WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 RPS6 RALA PPP2R2A MAP2K1 MAP2K2 RAF1 EGFR IQGAP1 EPS8 PIK3R1 CHN2 EGF STAT1 STAT3 ZFP36 MYL11 RALGDS MAP2K5 PPP5C DIAPH3 ARF4 DUSP6 PIK3CA MAPK7 MAP3K2 MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 CDC42 WASF2 MAPK8 MAPK1 RAC1 MAPK3 ABI1 MAP3K1 MAP2K4 KSR1 PPP2CA SMAD1 PPP2R1A ARPC1B BRK1 ACTR3 PLD1 ACTR2 PLD2 ARPC4 ARPC5 SRC BAIAP2 ARPC2 ARPC3 HRAS GAB1 SRF SLC9A1 PRKCA RPS6KA3 GRB2 SOS1 SH2D2A F2RL2 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE NUDC MAP1B CSNK2A1 PLA2G7 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 PAFAH1B2 CDK5R2 CDK5R1 PAFAH1B1 DYNLT1 CALM3 CDC42 ABL1 RAC1 LRPAP1 PPP2R5D IQGAP1 RHOA CDK5 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL ITGB1 RABGGTB CCNA2 RHOC RABGGTA PTP4A1 CDKN1A PTP4A2 PTP4A3 ATF5 ROCK1 MAPK1 EGR1 ITGA1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 CCNE1 RHOA BCAR1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 EFNB1 LYN SRC EPHB2 EPHB1 PIK3CA EPHB4 FGR HCK DNM1 NCK2 LCK PTPN13 MAP3K7 ITGB3 ITGA2B MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium VEGFD CREB1 MAPK14 PIK3CA SHC1 FN1 RPS6KA1 ITGB1 GRB2 SOS1 MAPK1 MAPK11 CRK ITGA4 FLT4 ITGA2 ITGA1 MAPK3 COL1A2 AKT1 ITGA5 COL1A1 MAP2K4 PIK3R1 VEGFC ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events ADAP1 MET SRC GNA14 GNA15 PXN GNA11 GNAQ NCK1 ARRB1 ADRB2 ITGB3 ITGA2B KIF13B FBXO8 TSHR LHCGR USP6 IQSEC1 ARAP2 ACAP1 IPCEF1 GULP1 ACAP2 AGTR1 EGFR HGF EFNA1 CYTH3 CYTH2 GIT1 ARF6 ARRB2 EGF EPHA2 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 PIN1 CDK6 SFN ADA BCL2L11 JAG2 GATA1 RACK1 HEY2 PML KAT5 PLPP1 MDM2 CCNA2 RCHY1 CDKN1A BRCA2 SERPINE1 CHEK1 MAPK11 FAS NEDD4L ABL1 MYC JAK1 IL1RAP EP300 IL4R BBC3 TUBA1A PEA15 FLOT2 RNF43 S100A2 AEN UBE4B CCNE2 NDUFS2 HAGH PFDN5 FBXO45 AFP CCNB1 PLK3 YAP1 GRAMD4 HSF1 BAX CLCA2 BAK1 WWOX BUB3 DEDD BUB1 GDF15 TP63 SIRT1 NSG1 TP53I3 MAPK14 WT1 TP73 DCP1B PLK1 FOXO3 ITCH FASN PRKACB CDK1 SERPINA1 CASP2 SP1 BIN1 CDK2 TP53AIP1 RAD51 NTRK1 RELA CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events GNAI2 MAPK14 MTOR CXCL13 PDPK1 CXCR3 CXCL10 SRC CXCL11 PIK3CA PF4 NRAS DNM1 HRAS MAPKAP1 PIK3CB ARRB1 MLST8 RICTOR GNG2 KRAS MAP2K6 MAP2K3 GNB1 MAP2K1 MAP2K2 MAPK1 MAPK11 MAPK3 RAF1 GNAI3 GNAI1 AKT1 CXCL9 PIK3R1 GNAO1 GNAZ CCL11 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB HDAC1 PRKACA PRKACG YWHAZ PIK3CA SHC1 OSM SRP9 CISH CNKSR1 IL3RA BCL2L1 CSF2RB PRKACB GAB2 PIM1 IL3 PTPN11 GRB2 PIK3R1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNAI2 ROCK1 ICAM1 PRKCQ PRKCD PRKCZ PRKACA GNA14 RAB11A GNA15 GNA11 GNAQ DNM1 PRKCB PRKCE PRKCH PRKG1 MAPK11 RAC1 SELE AKT1 SYK RHOA ARRB2 TGM2 GRK2 FYN YES1 BLK NHERF1 MAPK14 GNA13 LYN PIK3CG SRC PIK3R6 FGR HCK PTGDR PTGIR PLCB2 TBXA2R PRKCA LCK GRK3 VCAM1 ARR3 GNG2 PRKCG GNB1 ARHGEF1 GNB5 EGFR NOS3 EGF GNA12 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAE MST1 YWHAB ERBB2 YWHAQ MST1R SFN MET YWHAG YWHAH LAMA1 LAMA3 RPS6KB1 YWHAZ PIK3CA SHC1 IL1A HRAS COL17A1 ERBB3 PMP22 CD9 LAMA2 PRKCA LAMB3 ITGB1 LAMB2 LAMB1 ITGB4 LAMC2 CASP7 LAMA4 CDH1 GRB2 RXRB RXRA LAMC1 LAMA5 RXRG RAC1 AKT1 EGFR ITGA6 PIK3R1 EGF MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAE YWHAB SGK1 YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS MAPKAP1 CLIP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 AKT1 SREBF1 CYCS BTRC EIF4EBP1 EIF4E PLD1 PLD2 FBXW11 TSC2 MTOR RPTOR DEPTOR RPS6KB1 IRS1 AKT1S1 EEF2K RPS6KA1 HRAS PRR5 RB1CC1 TSC1 PRKCA ATG13 RRAGA RRAGC RRAGB DDIT4 RRAGD ULK2 ULK1 MAP2K1 RRN3 MAP2K2 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 RAF1 EIF4A1 CDK2 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway CHUK NFKB2 BTRC MAP3K14 RELB NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D TADA2B MCL1 RGCC JMY TAF9 BCL2L2 BTG2 SFN PPP1R13B TRIAP1 MET SMARCA4 CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 PMAIP1 DDB2 RNF144B E2F3 RRM2B JUN IRF5 TYRP1 HTT PML RPS27L PPM1J NLRC4 TP53INP1 PMS2 E2F2 DROSHA TIGAR DUSP5 ARID3A EDN2 MLH1 DUSP1 CEBPZ SERPINB5 TGFA RCHY1 CDKN1A SERPINE1 GADD45A HSPA1B CARM1 EP300 SNAI2 EPHA2 KAT2A TFDP1 PERP ATF3 BDKRB2 TSC2 HDAC2 IGFBP3 BCL6 NDRG1 BCL2L1 BCL2A1 NFYA NFYB NFYC E2F1 CASP6 BCL2 PIDD1 CREBBP CASP1 VDR APAF1 SP1 CSE1L EGFR DKK1 COP1 RB1 CCNG1 MAP4K4 LIF MDM2 CASP10 FOXA1 BID SPP1 FAS VCAN BBC3 MMP2 CTSD S100A2 CCNB1 PLK3 CAV1 AFP BAX BAK1 GDF15 TP63 TP53I3 COL18A1 CD82 TP73 PTEN PCNA DDIT4 POU4F1 CCNK STEAP3 PRDM1 POU4F2 PYCARD TRRAP SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 TP53 DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events ADCY7 ADCY9 ADCY4 ADCY3 ADCY2 RPS6KA5 ADCY1 ADCY8 CREB1 ADCY6 ADCY5 GNAL PRKACA LPAR4 PRKCE POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly PTPN1 MMP3 FYN ADAM10 MET GNA13 RET SRC PTPN6 RAB5A RIN2 HRAS GFRA1 SNX1 CASP3 CTNND1 ROBO1 RAB7A SLIT1 IGF1R DSP GDNF IGF2 CDC42 CDH1 CREBBP CABLES1 CTNNA1 ZBTB33 JUP MEP1B CBLL1 HGS TIAM1 DNM2 ABL1 RAC1 NME1 MMP7 EGFR IQGAP1 CTNNB1 NTRK2 CDH2 BDNF ARF6 EGF GNA12 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling PAK1 FZR1 GSK3B ARHGEF7 NFKBIA PRKACA CDC25B TPX2 NDEL1 MDM2 RAN CKAP5 BRCA1 AURKB RASA1 CENPA OAZ1 TACC3 DLGAP5 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D AURKA TP53 BIRC5 GIT1 TACC1 AJUBA CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 NFKBIA PIK3CG PIK3R6 PIK3CA JUN CBLB BCL2L1 MAPK9 PIK3CB IL4 CD40LG TRAF1 MAPK8 TRAF6 MAPK10 MAPK11 BIRC2 CD40 TNFAIP3 MYC JAK3 BIRC3 C4BPA MAP3K1 FCAMR AKT1 TRAF3 TDP2 MAP3K14 MAP2K4 PIK3R1 RELA TRAF2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network NEDD8 C3 SMARCA4 SMARCE1 NR0B1 NR0B2 ESR2 UBA3 NCOA3 NCOA1 SMARCB1 UBE2M DDX54 ZNF14 NCOA2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKC AURKB AURKA LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STRADA YWHAE STK11IP GSK3B STRADB YWHAB ETV4 STK26 SIK3 SIK1 YWHAQ SIK2 CREB1 SFN YWHAG YWHAH MARK2 TSC2 MTOR RPTOR PRKACA YWHAZ AKT1S1 MAPT HSP90AA1 MLST8 TSC1 SMAD4 CDC37 ESR1 EZR MYC BRSK1 CTSD CRTC2 BRSK2 SMARCD3 TP53 CAB39 PSEN2 STK11 MAP2 MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 EFNB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAPK14 EGR1 RAP1B MAP2K5 PRKCD MAPKAPK2 TRPV1 MAPK7 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS FOS SRF KRAS CDK5R1 MAP2K6 MAP2K3 MAP2K1 MAPK1 MAPK3 RAF1 RIT1 RIT2 EHD4 NTF3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway SMPD2 TNFRSF1A TNIK CAV1 MADD NSMAF TAB2 TAB1 NRK RFFL STAT1 MAP4K5 MAP4K3 ADAM17 MAP4K2 TNFRSF1B NFKB1 CYLD PRKCZ RACK1 MAP4K4 SMPD1 IKBKB CASP8 RIPK1 IKBKG MAP3K7 MAP3K5 FADD MAP2K7 PRKCI MAP2K3 MAP3K3 TRAF1 SQSTM1 BIRC2 TNFAIP3 BIRC3 TRADD MAP3K1 CHUK BAG4 TNF TXN RELA TRAF2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks INS AFP CREB1 CEBPB G6PC1 ACADVL ALAS1 DLK1 TAT SLC2A2 TTR UCP2 NKX2-1 ACADM PCK1 HADH IGFBP1 CPT1A PKLR HMGCS1 KCNJ11 ABCC8 FOXF1 PDX1 NF1 APOA1 FOXA1 HNF1A CPT1C FOXA3 CPT1B FOXA2 GCK BDH1 ALB ALDOB NR3C1 SP1 CEBPA HNF4A TFRC AKT1 CEBPD F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events GSK3B APC ARHGEF7 ARHGEF6 RASGRF1 PRKCZ DIAPH3 PIK3CA JUN BRAF MAPK9 PRKCE MAP2K7 ATF2 CDC42 MAP2K6 MAPK8 ENAH MAPK1 TIAM1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 PAK1 WASL CBL ARPC1B YES1 ARHGDIA ACTR3 ACTR2 PLD1 MAPK14 IQGAP3 MTOR PAK2 ARPC4 SRC ARPC5 RPS6KB1 BAIAP2 ARPC2 ARPC3 HRAS PAK4 MAP3K11 PARD6A CFL1 CDH1 MAP2K3 CTNNA1 LIMK2 LIMK1 EXOC7 PAX6 HES5 SEPTIN2 TNK2 CDC42BPA RAF1 MYL2 F2RL2 IQGAP1 CTNNB1 EPS8 PIK3R1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events GNAI2 CSK JAK2 STAT5A RALB STAT1 STAT3 RAP1B PDPK1 BAD RACK1 PRKCZ CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 CXCR4 HLA-DRB1 CDC42 PTK2B RAC1 AKT1 MMP9 RHOA BCAR1 ARRB2 GRK2 STAT2 PAK1 FYN RHOC INPP5D YES1 RHOB BLK STAT5B MTOR GNA13 LYN PIK3CG SRC PIK3R6 PTPN6 FGR PXN HCK FOXO1 PLCB2 ITCH SSH1 LCK PTPRC ARR3 CFL1 PTPN11 PTK2 GNG2 PLCB3 GNB1 LIMK1 PLCB1 HGS CRK CXCL12 RGS1 VPS4B VPS4A GNAI3 GRK6 GNAI1 UBQLN1 PAG1 PIK3R1 CD3E GNAO1 GNAZ VAV1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAE YWHAB HSPB1 YWHAQ CREB1 SFN MAPK11 YWHAG MAPK14 YWHAH TSC2 RAF1 MAPKAPK3 MAPKAPK2 YWHAZ ETV1 CDC25B TCF3 LSP1 TH SRF PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling GSK3B APC ADAM10 NOTCH1 CCND1 BTRC TAB1 DTX1 PPARD DLL1 CSNK1A1 RBPJ FBXW11 NEDD4 HDAC1 CTBP1 DVL1 CSNK2A1 JUN TLE1 FOS MAP3K7 HNF1A CREBBP LRP6 WIF1 MAPK1 FZD1 MAPK3 MYC PPP2R5D NKD1 PSENEN AXIN1 CTNNB1 NLK FRAT1 DKK2 WNT1 PSEN1 TLE5 APH1A KREMEN2 NCSTN DKK1 APH1B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms NQO1 TFAP2C SSRP1 DHRS3 YWHAQ ITGA3 ADA JAG1 PRKCD PMAIP1 PML IKBKB MDM2 ITGB4 SERPINB5 CABLES1 CDKN1A FAS GADD45A ABL1 EP300 CHUK BBC3 FLOT2 S100A2 SMARCD3 AEN SHH BAX CLCA2 BTRC MFGE8 GDF15 TP63 EGR2 PERP TP53I3 GPX2 PLK1 IGFBP3 WWP1 HBP1 ITCH VDR SP1 FDXR OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL CDKN2A IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL CAMK2D CAMK2A SOCS1 PTGES2 IRF9 JAK2 STAT1 DAPK1 STAT3 CAMK2B CEBPB RAP1B MTOR PRKCD PIK3CA IL1B RAP1A MAP3K11 IRF1 PTPN11 PIAS1 IFNG CALM3 CREBBP CASP1 MAP2K1 MAPK1 IFNGR1 SMAD7 CRKL MAPK3 RAPGEF1 PTPN2 JAK1 MAP3K1 AKT1 EP300 CAMK2G PIAS4 PIK3R1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 USO1 GBF1 CLTB AP2A1 PIP5K1A ARFGAP1 PLD2 GGA3 ARFIP2 RAC1 AP2M1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 NFKB1 IL1RN PRKCZ ERC1 TICAM2 IL1R2 PIK3CA JUN IRAK3 TOLLIP IL1B UBE2V1 IL1A IKBKB IKBKG MAP3K7 PRKCI UBE2N MAP2K6 MAP3K3 MAPK8 TRAF6 SQSTM1 IRAK1 CASP1 IRAK4 IL1RAP CHUK MYD88 PIK3R1 IL1R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network GSK3B FGG SGK1 STAT5A SFN STAT1 CSF2 CXCL8 ICAM1 SMARCA4 YWHAH EGR1 NFKB1 PPP5C PRKACA IL6 BGLAP JUN POU2F1 VIPR1 SUMO2 KMT5B NFATC1 POU1F1 FOS MAPK9 SMARCC2 TBX21 IL2 IL13 FKBP5 SMARCD1 IRF1 TSG101 IL4 MDM2 NR1I3 SMARCC1 CGA PCK2 IFNG PBX1 CDK5R1 KRT17 CDKN1A MAPK8 MAPK10 SPI1 MAPK1 MAPK11 NR3C1 SELE MAPK3 AKT1 EP300 NCOA1 NCOA2 CDK5 POMC AFP BAX NR4A1 CREB1 STAT5B TBP MAPK14 HDAC2 HDAC1 PRKACG GATA3 KRT5 HSP90AA1 KRT14 PRKACB CREBBP IL5 FKBP4 MMP1 PRL CSN2 TP53 RELA INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL ARHGEF7 LRIG1 SPRY2 ITSN1 SH3KBP1 SRC PIK3CA SHC1 RAB5A CBLB NRAS DNM1 EPS15 HRAS SYNJ1 PIK3CB USP8 TSG101 PTK2 KRAS UBE2D2 UBE2D3 ZFYVE28 SH3GL2 CDC42 EPN1 CHMP3 AMPH GRB2 STAMBP SOS1 HGS RAF1 UBE2D1 EGFR PIK3R1 EGF E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network SMARCA2 RB1 RBL2 CDKN1B MCL1 CDC6 YY1 E2F3 RBBP8 E2F2 CCNA2 CDKN1A PLAU SERPINE1 UXT MYBL2 SULT2A1 XRCC1 CES4A TFDP2 MCM3 MYC CES3 CES2 CES1 CBX5 CES1P1 EP300 TYMS CES5A ORC1 E2F6 E2F7 RANBP1 RRM1 RRM2 CDKN2C TFE3 CCNE2 DHFR POLA1 RYBP KAT2B PRMT5 KAT2A RBL1 TFDP1 SIRT1 TP73 WASF1 HDAC1 HBP1 RBBP4 TRIM28 E2F1 E2F4 CDK1 E2F5 CASP7 BRCA1 CCND3 CREBBP TOPBP1 APAF1 SP1 CEBPA TRRAP CDK2 CCNE1 HIC1 ATM TK1 CDC25A CDKN2A CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NOD2 TNFRSF1A RAN RIPK2 IKBKG UBE2D3 TRAF6 BTRC BIRC2 NFKB1 CYLD TNFAIP3 NFKBIA ERC1 CHUK BCL10 MALT1 ATM XPO1 TNF IKBKB PRKCA RELA EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EPHA5 FYN EFNA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CSK B2M TRPV6 HLA-A PLCG1 LAT CD8B PDPK1 CD8A PRKCQ RASGRP2 RASGRP1 CD86 CD80 PRF1 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 IKBKG KRAS TRAF6 GRAP2 AKT1 CHUK MAP3K14 ZAP70 CBL FYN SHC1 PTPN6 CARD11 BCL10 RAP1A MALT1 HRAS PRKCA LCK PTPRC GRB2 SOS1 PAG1 RASSF5 STIM1 ORAI1 CD3E VAV1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase YWHAE CDKN1B CCND1 IFNAR2 NFKB1 JUN FOS IL2 IRF1 IFNG TERF2 BLM MAPK1 SIN3B ABL1 SIN3A MAPK3 MYC AKT1 HUS1 NCL RAD1 TGFB1 PINX1 SAP30 RAD9A SMG6 E6 SMG5 PARP2 TINF2 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN WT1 ACD PTGES3 MTOR HDAC2 ZNFX1 HNRNPC HDAC1 RPS6KB1 MAX RBBP4 TERT E2F1 SAP18 HSP90AA1 RBBP7 MXD1 MRE11 UBE3A NR2F2 SMAD3 NBN ESR1 XRCC6 XRCC5 SP1 SP3 EGFR RAD50 ATM EGF REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET CSF2 SMARCA4 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 CDKN1A TGFB2 SPI1 MAPK11 ABL1 EP300 SMARCB1 MEF2C PPP2CA RUNX2 TFDP1 SIRT1 MYOD1 TBP MAPK14 MITF PPARG CEBPB SUV39H1 HDAC3 HDAC1 AATF CTBP1 BRD2 PAX3 RBP2 ATF7 DNMT1 CKM RBBP4 PPP2R3B GSC TAF1 E2F1 E2F4 SFTPD CCND3 CREBBP RAF1 CEBPA CDK4 CDK2 CEBPD CCND2 CCNE1 UBTF SKP2 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 SMAD3 MAPK1 TGFBRAP1 CTDSP1 CTDSP2 MAPK3 MAP3K1 KPNA2 NUP214 KPNB1 PIAS4 CTDSPL UBE2I NUP153 PPM1A HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network VEGFA MCL1 EDN1 EPO LEP NOS2 CITED2 SLC2A1 PGK1 LDHA HIF1A EGLN1 EGLN3 COPS5 JUN HMOX1 TF BHLHE40 FOS ABCG2 ID2 ARNT CXCR4 ITGB2 SERPINE1 ETS1 HNF4A NPM1 AKT1 EP300 NCOA1 FURIN NCOA2 TFF3 CREB1 ENG GATA2 NDRG1 HDAC7 TERT IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 PKM SMAD4 PLIN2 CREBBP GCK ALDOA ABCB1 SMAD3 PFKFB3 FECH NT5E BNIP3 CP PFKL CXCL12 SP1 TFRC ENO1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR GSK3B CBL ARHGEF2 FYN ITGA3 GRIN2B MAP1B PIK3CA LRP8 RAP1A RELN MAPT NCK2 MAP3K11 DAB1 ITGB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 GRIN2A CRKL MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 PIK3R1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway TNFRSF10C TNFRSF10B TNFRSF10A TNFRSF10D PIK3CA SMPD1 PIK3CB IKBKB CASP8 CASP10 RIPK1 IKBKG FADD MAPK8 CFLAR MAPK1 MAPK3 TNFSF10 DAP3 TRADD MAP3K1 CHUK MAP2K4 PIK3R1 TRAF2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNG2 CRH MAPK8 GNB1 MAPK9 MAPK11 MAPK14 GNAL SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP INS VEGFA PTPN1 INSR RAB4A STAT6 STAT5A STAT5B STAT1 MET STAT3 SRC PIK3CA SHC1 KPNB1 PIK3CB GAB1 ITGB1 PIAS1 KDR CREBBP PDGFRB GRB2 SOS1 ITGA1 JAK3 PTPN2 PDGFB CSF1R JAK1 LMAN1 EGFR KPNA2 HGF CSF1 EIF2A PIK3R1 ATR EGF EIF2AK2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GREM1 BMP2 GSK3B BMPR1A SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A BMP7 MAP3K7 SMAD4 ZFYVE16 PPP1R15A MAPK1 SMAD7 SKI CTDSP1 SMURF2 CTDSP2 BAMBI XIAP CHRD CHRDL1 NUP214 HJV BMP4 SOSTDC1 CER1 AHSG FST NOG BMPR2 SMAD6 RGMB BMP6 SMAD1 RGMA PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 ROCK2 F2RL3 GNB1 ROCK1 GNA13 MYL2 GNA14 GNA15 GNA11 F2RL2 GNAQ RHOA F2 PLCB2 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog DYRK1A IHH ARRB2 KIF7 MED6 KIF27 MED23 MED12 CDK8 CCNB1 ADRBK1 SUFU BOC SAP18 CTNNB1 GAS1 MED1 HEL2 DHH PTCH1 HHIP PTCH2 TCR%NETPATH%TCR TCR MAP2K1 SCAP2 MAP2K2 DYRK1A PRP4K ANXA11 DYRK1B LAX1 TUBA4A CD2AP DOK1 ACLY HGS NCL PARD3 ELMO1 ADAM9 PRKD2 PKP4 PRKD1 RAF1 STAM2 C10orf28 EPHA3 CARD11 KHDRBS1 TSG101 SHC1 TXK SH2D2A PXN STK39 PIK3R2 PIK3R1 PTTG1IP BCL10 STK4 LY9 LDHB SDCBP RAP1A INPP5D CASKIN2 PLCG2 LPXN BMF PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 HEL-S-133P NFATC2 LNPEP NFATC1 CGN NFKB1 CDC2 NFKBIA FER PTPRC EPRS1 UNC119 GRB2 GRAP DKFZp434N041 CALM1 ADA LAT NFKBIB GSK3B ITK MTMR10 DDX3X HSP90AB1 DDX49 HEL-S-30 CLTC GDI2 PTPN22 CD3G PTPRH SHB CD3E CD3D CABIN1 PIK3C2B IKBKB PSTPIP1 TUBA1A YWHAQ CTLA4 ZNF404 JAK3 NCK1 VAV3 DUSP3 CHUK ANXA2 SYK RIPK2 FCRL3 NFAM1 TUBB PGAM1 MSL2 GAB2 YWHAZ VAV1 VAV2 ACTA1 ZAP70 CREB1 BDH1 LCK RAPGEF1 PECAM1 C9orf78 LCP2 EVL ARHGEF2 DOCK2 SOS1 ARHGEF7 CRK SOS2 CEBPB SRC HEL-S-52 WAS NEDD9 ATP1A1 CBL RELA HDAC7 DNAJB1 MUC1 PAK1 MAPK8 MAPK7 PTK2B MAPK1 FLNB CCT8 SH2B3 MPZL1 MAPK3 GIT2 TRAT1 STAT1 ERBIN PTPN11 MAPK14 DEF6 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 CTNNB1 PTPN6 PIK3AP1 ACTR10 RAN ITSN2 ATF2 CYFIP1 CD84 CD82 TFRC WIPF1 HEL-S-81p DGKA CD80 SLA ENO2 ARHGAP35 CRKL GOLGA5 UBASH3B SIT1 GRAP2 ARHGDIB TRIM25 MAP3K8 HOMER3 KIRREL1 BCR%NETPATH%BCR BCR RPS6 FOS VAV1 LAT2 DOK1 ZAP70 CREB1 LCK BANK1 MAPKAPK2 RAPGEF1 BTK HCLS1 PRKCQ PRKD1 SOS1 CRK SOS2 CARD11 SHC1 ITPR2 NEDD9 PIK3R2 BCL10 RELA RASGRP3 CD79B CD79A CCL4 BTLA EIF4EBP1 CCL3 STAP1 MAPK1 PIP5K1A FYN PIP5K1C PLCG1 SH2B2 LYN PTPN18 JUN CD72 PLEKHA1 PLEKHA2 STAT1 STAT3 NFATC3 NFATC2 MAPK14 CDK7 HNRNPK TEC BCL6 RPS6KB1 CDK2 CTNNB1 FOSB CYCS BAX GRB2 PTPN6 FCGR2B CD22 RB1 ATF2 GSK3B ITK GSK3A IFITM1 SLA2 STM7 CRKL IKBKB CASP9 TCL1A RPS6KA1 BLNK PIP4K2A PIP4K2B FOXO3A JUNB GTF2I NCK1 MAP4K1 CHUK PDPK1 PRKCB IL1%NETPATH%IL1 IL1 MAP2K3 JUN FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 HEL-S-44 MAPK14 NFKB1 NFKBIA MAP3K7IP1 DOK1 IL1A IL1B TRAF6 PELI1 REL TAB3 UBE2V1 MAP3K14 MYD88 RB1 ATF2 HEL-S-71 IL1RN PIK3R2 PIK3R1 IKBKAP RELA IKBKB PPP6C MAPK9 MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 IL2%NETPATH%IL2 IL2 CDK2 IL2RB BCL2 GRB2 PTPN6 EIF3B ATF2 IRS1 PIK3CD YBX1 NR3C1 SHB ETS2 CRKL FOXO3A JAK3 JAK1 MAP2K1 MAP2K2 IL15 RPS6 GAB2 VAV1 CREB1 PIK3CA LCK CCNE1 PLCB1 RAF1 SGK1 SOS1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 IL2RG CBL PRKCZ RELA SOCS3 MAPK8 TERT EIF4EBP1 STAT4 PTK2B MAPK1 FYN EIF4E MAPK3 LYN STAT5B JUN PTPN11 NMI MAPK14 MTOR IL2 NFKB1 IL2RA IL3%NETPATH%IL3 IL3 MAP2K1 PRKCB BAD KCNIP3 PRKCA GAB2 YWHAZ NFKB1 DOK1 IL3 CREB1 PTPRC FES RARA PTPN6 CRK BCL2L1 ATF1 GSK3B GSK3A SHC1 PIK3CD CSF2RB PIK3R2 PIK3R1 GATA2 FOXO1 CRKL PPP2CA SOCS2 SOCS3 BCL2L11 RXRA INPP5D MAPK1 HEL-S-1 HRAS LYN IL4%NETPATH%IL4 IL4 INPP5D PLCG2 EP300 MAPK1 IL13RA1 JAK1 MAPK3 CREBBP CHUK SYK BAD IL13 STAT3 PTPN11 TYK2 MAPK14 SND1 NFKB1 IL4 NFKBIA MAPK11 H3-4 PIK3CA RPS6KB1 PTPN6 CEBPA ATF2 CEBPB CD40 SPI1 SHC1 PIK3CD CXCR4 IL2RG CBL IKBKB H3C15 MAPK8 SOCS1 IL5%NETPATH%IL5 IL5 JUN MAP2K2 SYK STAT1 STAT3 PTPN11 MAPK14 YWHAZ NFKB1 NFKBIA IL5 IL2RB RAPGEF1 CTNNB1 HCLS1 BAX UNC119 GRB2 RAF1 SOS1 ATF2 GSK3B GSK3A SHC1 IL5RA CBL CRKL SDCBP SOCS1 ALOX5 RPS6KA1 PTK2B FOXO3A HRAS SOX4 JAK1 LYN STAT5B IL6%NETPATH%IL6 IL6 RB1 GSK3B CD40 EP300 FOXO3A RAC1 IL6R MAP3K7 JAK1 EIF2A NCOA1 HEL-S-102 MAP2K4 MAP2K1 MAP2K2 FOS TYK2 GAB2 VAV1 BTK IL6ST SGK1 HDAC1 SHC1 PIK3R2 FOXO4 PIK3R1 NLK CBL FOXO1 SOCS3 MAPK8 ERBB3 ERBB2 EIF4EBP1 PTK2B MAPK1 FYN PLCG1 EIF4E MAPK3 MAP2K6 LYN STAT5B CREBBP JUN BAD STAT1 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 IL6 RPS6KB1 GRB2 IL-7%NETPATH%IL-7 IL-7 SHC1 STAT1 STAT3 PIK3R1 IL2RG FOXO1 IL7 MAPK1 FYN FOXO3A IL7R JAK3 MAPK3 GSK3B STAT5B GSK3A MAP2K1 MAP2K2 IRS1 BAD ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 MET PLEC COL17A1 LAMA5 CD151 SHC1 SRC LAMA3 PIK3R3 PIK3R2 MST1R PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA1 MAPK1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 LAMB2 BAD ERBIN LAMB1 PTPN11 MAPK14 MTOR EIF6 IL9%NETPATH%IL9 IL9 STAT5B KAT5 MAPK1 TYK2 IL9R MAPK3 RANKL%NETPATH%RANKL RANKL MAPK8 TRAF3 TRAF6 TRAF5 REL TNFSF11 ATP6V1E1 MAP3K7 SQSTM1 SPI1 CHUK TNFRSF11B TREM2 TRAF2 TRAF1 MAPK14 NFKB1 NFKB2 MAP3K7IP1 LEPTIN%NETPATH%LEPTIN Leptin MAPK8 CFL2 RPS6KA2 ERBB2 EIF4EBP1 PLCG2 MAPK1 FYN PLCG1 EIF4E SOCS7 JAK3 SH2B1 JAK1 NCOA1 CHUK STAT1 PRKCE LIMK1 RPS6 RUNX2 NFKBIA CDK5 RPS6KB1 LEP PDE3A GRB2 CRP KHDRBS1 GSK3B GSK3A PRKAA1 PRKAA2 ITGB5 IRS1 SHC1 SRC IRS4 SLC2A4 ACACB EGFR IGF1R IKBKB TSH%NETPATH%TSH TSH GNA13 GNAO1 IKBKB CREB1 GNA11 LEP CANX GNAS RAF1 MAPK3 MAP2K6 MAP2K3 GNAI3 SCRIB ATP1A1 HEL-S-99n GNAI1 TSHR HEL-S-89n IGF1R TSLP%NETPATH%TSLP TSLP MAPK1 EIF4E MAPK3 STAT5B MAP2K1 STAT1 STAT3 MAPK14 NFKB1 RELA NFKB2 RELB NFKBIA MAPK9 MAPK8 STAT4 FSH%NETPATH%FSH FSH MAP2K2 GRK4 FSHB FSHR CGA APPL1 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor HEL-S-102 CREB1 HDAC1 PIK3R1 NOTCH%NETPATH%NOTCH Notch PSEN2 DTX1 FURIN PIK3R1 RBPJ RELA DLL3 LFNG DLL4 YY1 APH1B SIN3A MAGEA1 EP300 MAPK1 CIRSR HES1 CCN3 SKP2 MAPK3 SKP1 SPEN JAG2 PSENEN SMAD1 HES6 FBXW7 STAT3 NFKB1 SAP30 RBX1 NCOR2 KAT2B SNW1 NCOR1 MFNG MAML3 TCF3 NOTCH2 GSK3B APP HDAC2 MAML2 SRC MAML1 FHL1 LEF1 EGFR1%NETPATH%EGFR1 EGFR1 TRIP6 SDC1 CC2D1A ARF4 PYGB CLTC RPLP0 CLTA AP2A1 PTPRK WASL ARHGAP5 SHB LIMD1 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 APPL1 JAK1 SERPINB3 CDV3 ANXA1 ANXA4 PGAM1 MINK1 FOS EPS15L1 TYK2 VAV1 VAV2 PLSCR1 GPRC5A KIT ARHGEF4 ARHGEF7 ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 EGFR RELA PAK1 PDZD11 AP2S1 FLNB RICTOR CD59 RPS2 LDLR MPZL1 GIT2 CAVIN1 CAVIN2 STAT2 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 ITCH KRT18 ARHA AXL NEDD4 PKN2 EPPK1 ESYT1 FRK SH3GL3 CTNND1 INPPL1 ARHGAP35 ARHGAP42 STK11 C11orf52 LAPTM4A CYSRT1 CDH2 GRB14 HNRPR GRB10 SIRPA KRT6A MAP2K3 MAGI1 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A PRP4K DYRK1B TOM1L1 EEF1A1 TOM1L2 DOK1 ADAM17 EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 STAMBP PKP3 RAF1 PHLDB2 COL17A1 KHDRBS1 HEL-S-132P DAPP1 FOXO4 LPP FOXO1 PLD2 EFNB2 SDCBP SOCS3 ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P NFKB1 PTPRE ARHGAP32 CDK5 SP1 CDK2 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 HEL-S-112 GSK3B DYRK4 GSK3A DYRK3 DOCK4 DDX3X USP31 CALCOCO2 ITGB4 HEL-S-30 HEL-S-115 HEL-S-36 PTEN PIK3CD HEL-S-34 PIK3C2B RBM3 CASP9 FLOT1 NCK2 HEL-S-1 CCDC50 NCK1 ACTR3 TGIF1 ACTR2 PDCD6IP PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK MYH9 DSG2 CRK DOCK1 MET SLC25A6 PLEC CEBPA CEBPB PRKAA1 PRKAA2 RALB WBP2 HDAC1 RGS16 MVP ITLN2 ASAP1 ATP1A1 SRI CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 SLITRK6 REPS2 PTK2B MAPK1 CSK FYN RBBP7 MTA2 PDLIM4 SH2B1 SNCA PTPN18 PTPN1 PPP1R14B HEL-S-43 EGF BAD SPRY4 BAIAP2 MAPK14 MTOR H3-4 RPS6KB1 SPRY2 SPRY1 KRAS PTPN6 TIEG2 DNCL1 SPG20 NECTIN1 ZPR1 ATF1 ITSN2 USP6NL APP ERRFI1 RPL30 AHCYL1 TFRC ZDHHC5 ARAF HEL113 CBLC HEL114 ENO1 ANTXR1 CRKL RPS6KA3 GJA1 BAIAP2L1 RPS6KA5 TFG SNRPD2 UBASH3B TRIM29 MYC RPS6KA2 RPS6KA1 EPHB2 ANKS1A TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 PRKCI ACTN1 KRT7 FRS2 SCRIB PRKCA KRT5 ACTN4 FRS3 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 RBCK1 PRKD1 EPHA1 PFN1 TLN1 RIN1 EPHA2 GRB7 SDC4 CTBP1 SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP IQGAP1 MYL12B HEL-S-15 SLC5A5 MYO6 PLCG2 COX2 PLCG1 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR BRAF CDC2 SMU1 CYLD ID%NETPATH%ID ID RBL1 PSMD4 CDK2 ID3 MAPK1 HES1 TCF3 RAF1 ATF3 MYF5 MAPK3 RB1 TCF7L2 MAP2K1 MAP2K2 SMURF2 FHL2 PAX5 ELK3 RBL2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PTPRU ATF2 GSK3B WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 EP300 HRAS JAK3 HEL70 PRKCB RPS6 MATK PRKCA PIK3CA KIT RAF1 SOS1 EZR CRK GRB7 SRC WAS CSF2RB PIK3R1 RELA MAPK8 SOCS1 INPP5D EIF4EBP1 MAPK1 FYN SOCS6 SOCS4 SOCS5 STAT5B JUN YES1 STAT1 RDX PTPN11 TNFRSF10A MAPK14 EPOR c-fgr MTOR MAPK12 KITLG TEC RPS6KB1 FES CDK2 GRAP IL7R MAD2L1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor CTNNA2 E2F4 SAMD3 MAPK3 NFYA NR1i1 NFYB NFYC PML FKBP1A SKI MAP3K7IP1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC SNIP1 FOXO3A SOX9 BTRC JUNB VPS39 SKP1 MAP2K3 NUP214 MEF2C ANAPC7 RUNX3 RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B EWSR1 CCNE1 SIK1 ANAPC5 ATF3 ANAPC1 ANAPC2 SDC2 PXN PIK3R2 FOXO4 PIK3R1 ANAPC10 FOXO1 SNX4 CCNB2 SNX1 SNX2 SPTBN1 MAP2K6 SNX6 WWTR1 JUN SMAD4 JUND TGFB1 UBE2I STK11IP SMURF1 IRF2BP1 NUP153 SMAD6 CDK6 COPS5 SNW1 CDK4 SP1 DYNLRB2 DCP1A TP73 GSK3B CDKN1A CITED1 CTCF ARRB2 BRCA1 XPO4 SUMO1 MAP4K1 NCOA1 PDPK1 HEL-S-72p FOS PJA1 TGFBR2 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 PIK3CA TFDP2 CRK CD44 ENG YAP1 PPP1R15A HDAC1 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 WNT%NETPATH%WNT Wnt DIXDC1 ARRB2 STM7 SOX1 CCND1 HEL-S-1 RAC1 MAP3K7 PRKCB AXIN1 KREMEN1 PRKCA DKK1 PAX2 SFRP1 DAAM1 ARHGEF4 ROR1 PI4K2A CTBP1 LEF1 LRP5 NLK MESD PPP2CA MAPK8 FRZB GPC3 DVL3 WNT1 WNT3 FZD1 SMAD1 TCF7L2 JUN YES1 JUP FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD9 NFATC2 BCL9 CDK6 ARHA PIN1 TCF4 TNFALPHA%NETPATH%TNFALPHA TNFalpha DOK1 TXLNA CDC34 FANCD2 CDC37 MAPKAPK2 TXNIP TRIB3 NUPR1 FKBP5 NSMAF COPB2 PSMD12 DIABLO PSMD13 TXN TNFRSF11A FOXO1 GLG1 BAG4 BRINP1 G3BP2 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A MCC NFKB1 SMARCA4 CDK9 NFKBIA REL ALPL TAB3 GRB2 NFKBIE MAP3K11 BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 FAF1 IKBKAP PPP6C YWHAQ BCL7A SUMO1 PPP1R13L NKIRAS1 CASP10 NKIRAS2 CASP3 NFKBIZ CASP2 HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 RIPK3 PEG3 ACTL6A COMMD1 TNFRSF1B YWHAZ CREB1 RASA3 TRAF4 MUXA POLR1A TRAF6 TRAF5 POLR1C POLR1D MCM5 PFDN2 SOS1 SOS2 BIRC2 BIRC3 HDAC2 HDAC1 SRC USP11 AKAP8 MTIF2 NR2C2 TANK HDAC6 EGFR RELB MAPK9 PAK1 MAPK8 RXRA ERBB3 TIFA FLNA MAPK1 ROMO1 POLR2H RFFL POLR2L MAPK3 MAP3K2 SMARCE1 RNF25 STAT1 PTPN11 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 ITCH GLB1 TNIP2 PRC1 PSMC1 BAX PDCD2 TBKBP1 PKN1 TRIM32 RB1 RPL4 RPL30 HEL2 IRS1 UBE2D2 UBE2D3 ZFAND5 RPL8 TNF DCAF7 RPL6 FBL PSMD6 TBK1 PSMD7 RPS6KA5 PSMD2 PSMD3 PAPOLA KPNA6 DPF2 EP300 PSMD1 TNFRSF8 MAP3K8 KPNA2 RPS11 BTRC JUNB KPNA3 RPS13 GTF2I MAP3K5 SKP1 SMARCC1 SMARCC2 CSNK2A1 FBXW11 FBXW7 USP2 CYBA PRKCA 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis PLCB3 DAGLA LIPH LPL PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNB4 GNB3 GNB5 KCNK3 KCNK9 GNAI3 PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 GNAO1 GNB2 GNB1 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCL1 PRKCD PRKCA GNG12 GNG11 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 HTR2B HTR2C HTR2A PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 HTR4 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 TPH1 DDC 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 ALDH3B2 IL4I1 ALDH2 ALDH1B1 ALDH1A2 ALDH1A1 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway PNP HPRT1 XDH ADA PRTFDC1 APRT ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC6A2 SLC18A1 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG PRKCE PRKCD ITPR1 PRKCA ADRA2C ADRA1B ADRA2B ADRA1A ADRA2A PLCB3 PLCB4 GNA11 PLCE1 PLCB1 PLCB2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway APP KAT5 PRKCG PSENEN PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA BACE1 CACNB1 CACNB2 BACE2 ADAM17 PRKCQ PKN3 CHRNA7 PSEN2 CACNA1D PSEN1 CACNA1C CACNA1F KLC1 PRKCZ MAPK9 KLC4 MAPK8 KLC3 NCSTN MAPK7 APH1B KLC2 MAPK1 CACNA1S MAPK6 MAPK4 MAPK3 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 APBA1 PKN2 CHRFAM7A PKN1 APBA3 APBA2 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT8A LRP4 WNT8B LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 APBB3 WNT2 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A TCF7L1 FZD3 FZD2 JUP FZD5 WNT3A FZD4 FZD7 WNT7B FZD6 FZD9 WNT7A FZD8 LRP1B AFDN ACTC1 CTNNB1 NECTIN1 APP GSK3B WNT2B FZD10 RBPJ ACTB ACTG2 ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 KAT7 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 BACE1 ACTA2 ACTA1 BACE2 ACTBL2 CD44 NOTCH2 RBPJL NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 PSEN2 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis CYP19A1 LIPA SOAT1 SOAT2 HSD17B1 HSD17B2 HSD17B3 HSD17B6 HSD17B7 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis PLA2G4A FOS RHOC RHOA RHOB PIK3CA RASA1 BIRC5 PIK3C3 CRYAA SOS1 CRYAB CRK SOS2 RBPJL SRC DLL1 DLL3 DLL4 NRAS MAPK8 PAK1 MAPK1 PAK3 PAK2 MAPK3 TCF7L2 MAP3K1 ANGPT1 NOS3 STAT1 WNT7B STAT3 WNT7A MAPK14 DLK1 VEGFA APC CTNNB1 TEK ARAF FGF1 RBPJ ETS1 CRKL GRB14 AKT2 AKT3 KDR AKT1 EPHB2 EPHB1 EPHB3 PRKCG PDGFRB PDGFRA MAP2K4 PRKCI MAP2K1 PRKCH MAP2K2 WNT5B PRKCB PRKCE F2R WNT5A PRKCD PRKCA FRS2 FRS3 DOK1 DOK2 DOK3 MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PRKD2 PRKD1 RAF1 EPHA3 NOTCH2 GRB7 SHC2 NOTCH1 SHC1 NOTCH4 SH2D2A TCF7 PXN PDGFB PDGFA PIK3R3 PIK3R2 PIK3R1 PLD1 PRKCZ HIF1A PLD2 EFNB2 EFNB1 PDGFD DVL1 PDGFC DVL2 PLCG2 LPXN DVL3 PLCG1 WNT1 WNT2 FZD1 JAG2 WNT10B JUN WNT10A FZD3 JAG1 FZD2 FZD5 BRAF PTK2 GRAP FGFR1 PRR5 GSK3B ARHGAP8 WNT2B TGFB1I1 ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 NCK2 HRAS NCK1 JAK1 APC2 PLA2G4D SPHK2 PLA2G4B SPHK1 PLA2G4C AXIN1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin PLCB1 PLCB2 ITPR1 ITPR2 ARRB1 ITPR3 ARRB2 ELK1 GRK3 GNG10 GNG3 GNGT2 GRK2 GNG4 GNG7 MAPK1 GNG8 MAPK3 EGR1 MAP2K1 MAP2K2 PRKCA GNG11 AGT PLCB3 GNAQ GNB2 GNB1 AGTR1 GNB4 GNB3 GNB5 RAF1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway TNFRSF1A PIK3CA MADD LTA ATF7 PRKCQ LTB TP53 ATF6 ATF3 BIRC2 JDP2 ATF4 BIRC3 ATF6B DIABLO CREM XIAP RELA RELB MAPK9 MAPK8 BCL2L11 MAPK1 RIPK1 FADD BAK1 MAP2K7 MAP4K3 MAP4K4 MAPK3 JUN MAP3K1 CRADD BIK TNFRSF10C TNFRSF10B GZMB EIF2AK2 TNFRSF10A EIF2S1 IGF2R NFKB1 GZMH NFKB2 TNFRSF10D NFKBIA MAPK10 PRKRA BCL2 REL FAS CYCS BAX MAP3K14 BCL2L1 ATF1 ATF2 TRADD PIK3CD FASLG PIK3CB TNF PIK3CG IKBKB CASP9 CASP7 CASP8 AIFM1 CASP10 AKT2 CASP3 AKT3 TNFSF10 AKT1 MAP3K5 PRKCG MAP2K3 MAP2K4 MAP4K2 DAXX PRKCH ENDOG APAF1 CHUK PRKCB PRKCE PRKCD PRKCA TRAF2 FOS TNFRSF1B ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis CPS1 CAD ASL NAGS ASS1 OTC ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin NTN4 PIK3CD PIK3R3 PIK3R2 PIK3R1 PIK3CB PIK3C2A NTN1 PIK3CG NTN3 PIK3C2B PIK3R5 CDC42 ABLIM1 RAC2 PLCG2 PLCG1 RAC1 VASP NTNG1 NTNG2 DCC UNC5B NFATC3 NFATC2 UNC5C UNC5D NFATC4 PIK3CA RHOU AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins PLXNA1 PLXNB1 FYN ARHGEF1 RAC1 FRK NRP1 SEMA4D DPYS SEMA3A CRMP1 RHOA PAK1 DPYSL4 CDK5 FES DPYSL5 DPYSL2 RAC2 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo SLIT3 SLIT2 RAC1 SRGAP1 NTNG1 NTNG2 DCC NTN4 CXCR4 RHOC NTN1 NTN3 ROBO1 CDC42 CXCL12 SLIT1 ABL1 RAC2 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation ARAF PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB RAC2 BLNK RAC1 HRAS VAV3 MAP2K1 MAP2K2 CHUK SYK PRKCB NFKBIL1 PRKCD FOS VAV1 VAV2 PIK3CA BTK RAF1 SOS1 SOS2 ITPR1 ITPR2 ITPR3 CD79B CD79A MAPK9 NRAS MAPK8 CD19 PLCG2 MAPK1 MAPK3 LYN MAP3K2 MAP3K3 JUN MAPK14 MAPK12 MAPK13 NFKBIA MAPK10 MAPK11 PTPRC PTPN6 GRB2 CALM1 CD22 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB ADRB1 PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway GNAL GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 ADRB2 GNG12 ADCY7 GNG10 GNG3 GNGT2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNB4 GNB3 GNG8 GNB5 ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL GNG2 ADRB3 GNG5 GNG4 GNG7 GNB2 GNB1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 ITGA2B SERPINA10 PROZ PLG PLAT TFPI KNG1 THBD PLAU FGB FGA F10 VWF GP1BB F12 FGG F2R PLAUR GP1BA F2 F3 GP5 F7 GP9 PROCR F8 F9 PROC F13B KLKB1 F2RL3 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway TCF7L1 PCDH9 PCDHGC5 PCDH7 WNT7B PCDHGC4 PCDH8 PCDHGC3 PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 ACTC1 PCDHB16 CTNNB1 PCDH11Y CTNND2 CTNND1 PCDH11X FZD10 CELSR1 CELSR2 CDH9 CDH8 ACTB ACTG2 CELSR3 ACTG1 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 PCDHAC2 PCDHAC1 WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 WNT6 PCDHA1 CDH20 CDH22 CDH23 PCDHA5 CDH24 PCDHA4 PCDHA3 PCDHA2 WNT1 PCDHA9 WNT2 PCDHA8 WNT3 PCDHA7 WNT4 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 FZD7 PCDH20 FZD6 FZD9 FZD8 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 PCDHGA8 ACTR2 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 LEF1 WNT8A WNT8B FSTL1 WNT11 PCDH1 PTPN1 TCF7L2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 MAPK10 RPS6KB1 CAMK4 CTNNB1 BAX BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 PLAU CDH1 PRKACG RPS6KA1 AKT1 PRKACA PRKACB IER3 MAP2K4 MAP2K1 MEF2C PRKCH MAP2K2 MEF2B PRKCB PRKCE RPS6 PRKCD PRKCA PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PXN CREM ITPR1 PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA SP1 RHEB GNB1 SP3 SNAI1 BCL2 TCF4 GRB2 CALM1 MAP3K14 MAP3K11 BCL2L1 ITGB1 RYR1 GSK3B RYR2 CXCL8 YWHAB HSPB1 ARRB2 PIK3CB ELAVL1 RYR3 PPP3CA CASP3 CD38 GAST ITGAV NOS1 RAC1 JAK2 SLC18A2 PRKG1 PDPK1 MMP3 PLA2G4A FOS RHOA CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF GUCY2D ROCK1 SRC SRF ODC1 ADCY1 PTGS2 NR2C2 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 GNG2 MAPK7 MAPK1 PTK2B EIF4E MEF2D MAPK3 BAD STAT3 CCK PTPN11 MAPK14 TPCN2 TPCN1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis HMGCS1 IDI2 PMVK MVD PDSS1 HMGCR LSS FDFT1 FDPS SQLE MVK GGPS1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system BMAL1 CLOCK PER2 PER1 PER3 CRY2 CRY1 CSNK1D CSNK1E COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK2 PANK3 PANK1 PPCS DCAKD COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG5 GNG4 GNG7 GNA11 GNAQ GNB2 GNB1 CRH GNB4 GNB3 GNG8 GNB5 GNG12 CRHR1 CRHR2 POMC GNA14 GNG10 GNG3 GNGT2 GNAL GNG2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 ARPC1B ARPC1A STMN4 WASL ACTB ACTG2 MYLK3 ACTG1 MYLK TUBB8 TUBB6 TUBB3 CFL2 STMN1 CFL1 TUBB1 RAC2 RAC1 TUBB RHOC ACTA2 MYH1 ACTA1 TUBB2B MYH2 MYH3 TUBB2A ACTBL2 MYO3B MYO3A MYH8 MYH9 RHOU PFN1 MYH4 MYH6 PFN3 MYH7 PFN2 ROCK1 ROCK2 CDC42 PAK1 MYH13 MYH14 PAK6 MYH11 PAK3 MYH10 PAK2 PAK5 PAK4 MYH7B LIMK1 ARPC4 ARPC5 TUBB4B TUBB4A DIAPH1 DIAPH2 ACTC1 ARPC2 ARPC3 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis AK1 GMPS AK2 AK3 AK4 AK5 AK8 ATIC GUK1 PPAT RRM1 ADSL RRM2 NME2 NME3 NME4 NME5 NME1 NME6 RRM2B NME7 IMPDH2 ADSS1 ADSS2 GART DSCAML1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM2B NME2 NME3 NME4 TYMS DSCAML1 NME1 ADAT2 DTYMK RRM1 DUT RRM2 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis CTPS1 DSCAML1 NME1 DHODH CPS1 CAD NME2 NME3 CTPS2 NME4 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication TOP1 DNA2 TOP2A RFC5 TOP2B RFC3 PCNA RFC4 RFC1 RFC2 PRIM1 RPA2 POLA1 H3-5 H3-4 POLD1 POLD2 PNAT%PANTHER PATHWAY%P05912 PNAT PRKAR2A PRKACG EPB41L3 FLNA GNG8 DRD1 STX3 DRD2 PRKACA SNAP29 PRKACB DRD4 SLC18A2 DRD5 GNG11 PPP1CA VAMP8 GNB2 GNB1 PPP1R1B GNB4 GNB3 VAMP1 KCNK3 VAMP2 VAMP3 CLIC6 GNAZ SNAP25 KCNK9 EPB41 SNAP23 GNAI3 PRKX ADCY2 ADCY7 GNAI1 SLC6A3 GNAI2 PPP1CC GNG3 PRKAR2B GNG4 EPB41L1 EPB41L2 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PRKD2 PRKD1 RAF1 SOS1 SOS2 PHLDB2 SHC2 SHC3 SHC1 RASAL2 PRKCZ EGFR PIK3R5 MAPK9 NRAS MAPK8 RRAS ERBB3 ERBB4 ERBB2 PLCG2 STAT4 MAPK1 STAT6 PLCG1 MAP2K7 MAPK3 MAP2K6 STAT5A MAP3K2 STAT5B MAP3K3 STAT1 STAT2 STAT3 SPRY4 DAB2IP BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 NF1 SPRY2 SPRY1 GRAP ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 PEBP4 AKT3 RAC2 AKT1 RAC1 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD GAB1 RRAS2 PRKCA GAB3 GAB2 MRAS PIK3CA RASA4 PRKD3 RASA1 RASA2 PRKCQ PIK3C3 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNG3 PLCB3 GNGT2 GNG5 CNR1 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 PLCB1 PLCB2 GNAI3 CACNA1B CACNA1A GNG11 GNAI1 GRM1 CACNA1G GNAO1 GRM5 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1B1 ARAF EDNRA EDNRB PRKACG AKT2 AKT3 AKT1 PRKG2 PRKACA PRKACB PRKG1 PRKCG GUCY1A2 EDN1 PRKCI GUCY1A1 MAP2K1 EDN2 PRKCH MAP2K2 EDN3 PRKCB PRKCE PRKCD PLA2G4A PRKCA PLCB3 ADCY9 PLCB4 PRKAR1B PRKAR1A PRKCQ RAF1 PLCB1 PLCB2 ITPR1 ADCY4 ADCY3 ITPR2 ADCY2 ITPR3 ADCY1 ADCY8 ADCY7 PRKCZ ADCY6 ADCY5 GNA14 PRKAR2B PRKAR2A GNA11 MAPK1 MAPK3 NOS3 ADCY10 GNAL GNAQ GNAS ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release GNB3 GNB5 OPRD1 GNAI3 CREM PRKX ADCY2 ADCY7 GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNG2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG PENK GNG8 PRKACA PRKACB OPRM1 PDYN GNG12 GNAO1 CREB1 GNAL GNB2 GNB1 GNB4 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway FAF1 CAPG FASLG LMNB2 LMNB1 CASP9 MAPK9 MAPK8 CASP7 CASP8 SCIN CASP6 CASP10 CASP3 LMNA FADD MAP3K5 DFFB MAP2K4 JUN DAXX PARP3 GSN PARP4 APAF1 PARP1 PARP2 CFLAR MAPK10 FAS FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway SPRY2 SPRY1 PTPN6 GRAP FGFR4 FGFR3 FGFR2 FGFR1 ARAF PIK3CD PEBP1 PIK3CB PIK3C2A PIK3CG PIK3C2B AKT2 AKT3 RAC2 AKT1 RAC1 MAP3K6 HRAS MAP3K4 MAP3K5 PRKCG MAP2K3 MAP2K4 PRKCI MAP2K1 RASA4B PRKCH MAP2K2 PRKCB PRKCE PRKCD PRKCA FRS2 FRS3 PIK3CA RASA4 RASA1 RASA2 PRKCQ PIK3C3 RAF1 SOS1 SOS2 SHC3 SHC1 PRKCZ MAPK9 NRAS MAPK8 PLCG2 MAPK1 PLCG1 MAP2K7 MAPK3 MAP2K6 MAP3K2 MAP3K3 SPRY4 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 SPRY3 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis DHFR DHFR2 MTHFD1L MTHFD2 MTR TYMS FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism HK1 KHK GALE GALT HKDC1 ALDOC ALDOB ALDOA HK2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 GNGT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 PRKACA PRKACB KCNJ3 GABBR2 GABBR1 GNG11 GNAO1 ADCY9 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ALDH5A1 GAD1 GAD2 ABAT CSAD GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 GTF2A1L BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBP RRN3 CAVIN1 TTF1 PSMC3IP TAF1B TAF1C TBPL2 POLR1B TAF1A POLR1D UBTF TAF8 TBPL1 POLR2K GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion GLUD1 GLUD2 LGSN GLUL GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GAPDH PFKM GPI TPI1 PKLR PGAM2 ENO1 BPGM ENO2 HK2 HK1 PFKL PKM HKDC1 PGK1 PGAM4 ALDOA UNTITLED%PANTHER PATHWAY%P06664 untitled TGIF1 SKIL RELA HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SUFU GLI1 BTRC GLI3 SHH CREBBP SMO STK36 FBXW11 PTCH1 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis HMBS RSAD1 CPOX PPOX COX10 EARS2 ALAD EPRS1 FECH QARS1 UROD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 HTR4 HTR6 HTR7 CREB3L3 CREB3L4 ADORA3 PRKACG CREB3L1 CREB3L2 ADORA1 EP300 PRKACA PRKACB PHKA1 PHKA2 MTNR1A ADCY9 PRKAR1B PRKAR1A MTNR1B CREM ADRB1 ADRB2 RAP1B HRH1 GNG10 RAP1A HRH3 HRH2 PRKAR2B PRKAR2A CLTCL1 HRH4 DRD1 DRD2 DRD4 DRD5 CREBBP HTR1E HTR1F HTR1D HTR1A HTR1B PHKB GNG12 GNAL GNB2 GNB1 CALM1 PYGB GSK3B GSK3A CLTC CLTB HTR2B CLTA HTR2C PYGM ADRA1D PYGL HTR2A ADRA1B ADRA1A GRM1 GYS2 GNGT1 GRM3 GYS1 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 GRM8 GNRHR SSTR1 OPRM1 ADRA2C SSTR2 ADRA2B SSTR3 SSTR4 SSTR5 CREB3 CREB1 ADRB3 ADORA2A ADORA2B CREB5 OPRD1 GNAI3 OPRL1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 ADCY5 GNAI2 GNG3 GNG2 GNG5 PHKG1 GNG4 GNG7 PHKG2 GNG8 KCNJ3 KCNJ5 KCNJ6 KCNJ9 OPRK1 GPR50 HTR5A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway ADORA2B PRKCQ ARHGEF1 PLCB1 PLCB2 OPRD1 GPR45 OPRL1 CACNA1B ITPR1 CACNA1A ITPR2 ITPR3 RASGRP2 RASGRP1 PRKCZ CACNA1E DNAJC27 RAP1GAP RASGRP4 RASGRP3 RAP1B GNA14 GNG10 GNG3 GNG2 RAP1A GNG5 GNG4 GNG7 GNA11 CLTCL1 GNG8 DRD1 DRD2 DRD4 DRD5 OPRK1 GNG12 GNG13 GNAO1 GNAQ GNB2 GNB1 GNB4 GNB3 CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 CLTC CLTB CLTA GRM1 GNGT1 GRM3 GRM2 GRM5 GNGT2 GRM4 GRM7 GRM6 ADORA3 GRM8 BDKRB2 ADORA1 GNRHR BDKRB1 GARNL3 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA SSTR1 OPRM1 SSTR2 SSTR3 SSTR4 RHOA SSTR5 PLCB3 PLCB4 ADORA2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction CALML3 PDC GNGT1 GRK1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 RHO CNGA1 GNG8 PDE6B CNGA3 GNAT1 PDE6A RGS9 RCVRN PDE6G GNG12 GNG13 GNB2 GNB1 GNB4 CNGB3 GNB5 CALM1 CNGB1 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 HRH1 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway GNG2 GNG5 HRH2 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 PRKACA PRKACB PRKX ADCY2 GNG12 ADCY7 GNG10 GNG3 GNGT2 GNAL HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease CYFIP2 CYFIP1 ARPC5L ACTB ACTG2 ACTG1 TUBB8 TUBB6 CAPN9 CAPNS1 CAPN6 TUBB3 CAPNS2 CAPN7 CAPN5 TUBB1 CAPN2 CAPN3 EP300 CAPN1 TP63 DYNC2H1 MAP2K4 DYNC1LI1 DYNC1LI2 GAPDHS TP53 KALRN GRIN2A CYC1 MAP2K7 JUN CREBBP BDNF ARPC5 GRIN2C GRIN2B GRIN2D GRIN3A SP1 DLG4 MAP3K10 DNAL4 TP73 HIP1 ARPC1B GRIK5 ARPC1A CLTB GRIK3 GRIK4 AP2A1 GRIK1 GRIK2 AP2A2 CASP8 CASP3 RAC2 RAC1 IFT57 ACTR2 DNAI2 TBP APAF1 TUBB RHOG FOS DYNLL1 DYNLL2 ACTA2 ACTA1 TUBB2B TUBB2A ACTBL2 RHOJ HAP1 GAPDH RHOQ DNAH3 DYNC1I2 DNAH7 DCTN1 DNAH8 DNAH5 HTT CDC42 MAPK9 DYNC1I1 DYNC1H1 HIP1R TUBB4B TUBB4A GRIN1 CAPN11 ACTC1 CAPN12 CAPN10 TAF4 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN1 CREBBP EGLN3 EGLN2 RORC ARNT TXN HIF1A MTOR TXN2 AKT2 AKT3 AKT1 VHL INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway CX3CL1 IKBKB PLCZ1 RAC2 CCR9 CCR8 ITGB7 CCR7 CCR6 RAC1 JAK2 CCR5 CCR4 PF4V1 CCR3 CCR2 CHUK VWF PDPK1 RHOG RHOC VAV1 RHOA ACTA2 MYH1 ACTA1 PLCB3 MYH2 MYH3 PLCB4 IFNG PIK3CA ACTBL2 MYO3B COL6A2 COL6A1 MYO3A MYH8 COL6A3 MYH9 SOS1 PLCB1 MYH4 PLCB2 MYH6 MYH7 CX3CR1 NFAT5 CCL13 CAMK2D CCL11 ROCK1 CAMK2A GNAI3 CXCR5 CXCR4 PRKX ADCY2 CXCR6 ADCY6 GNAI1 RELA ADCY5 GNAI2 RELB CDC42 GNA14 NRAS GNG3 PAK1 GNG2 CCL8 CXCR1 GNG5 CCL7 GNG4 GNG7 CCL5 GNA11 CXCR3 CCL4 CXCR2 CCL3 CCL2 MAPK1 PTK2B PAK6 GNG8 PAK3 CCL18 PAK2 PAK5 PAK4 MAPK3 CCL22 CCL21 CCL20 PLCL1 STAT3 ACTC1 KRAS PLCD4 PLCD1 CCL27 PF4 CCL26 MYLK2 CCL4L2 COL12A1 ARAF ARPC5L ACTB ACTG2 MYLK3 ACTG1 MYLK PREX1 PRKACG AKT2 CCRL2 AKT3 AKT1 PLCE1 PRKACA JUNB PRKACB PRKCB PRKCE CASK LTB4R2 RAF1 IFNAR1 SHC1 CCL3L3 C5AR1 FPR1 ITPR1 ITPR2 FPR3 ITPR3 PRKCZ GNG10 RRAS PLCG2 MYH13 MYH14 MYH11 PLCG1 MYH10 CCR10 CCR1 MYH7B JUN JUND XCR1 NFATC3 NFATC2 NFATC1 ARPC4 ARPC5 GNG12 IL2 NFKB2 NFATC4 GNAO1 CXCL10 ARPC2 ARPC3 GNAQ COL20A1 GNB3 GRAP ITGB1 CXCL8 COL14A1 ARPC1B ARPC1A PIK3CD PIK3CB ITGAL PIK3CG INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade IRS1 IRS4 IRS2 ELK1 INS IGF1R RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 MAPK3 MAP2K3 MAP2K1 MAP2K2 INSR INSRR IGF2 FOS IGF1 IGF2R RPS6KB1 RASA1 RPS6KB2 RAF1 SOS1 SOS2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade TPTE TSC1 IRS2 IGF1 FOXO3 IGF2R FOXO1 INS IGF1R PIK3CA MDM2 MDM4 GSK3B GSK3A PDPK1 IRS1 INSR INSRR IRS4 IGF2 PTEN TSC2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway ITGB8 COL10A1 ITGAV ITGB7 ITGB6 RAC1 HRAS ITGA4 ITGA3 ITGA2 ITGA1 RHOC RHOA ARFGAP1 RHOB RAP2C ARHGAP10 RAP2A COL2A1 RAP2B PIK3CA ITGAD ACTBL2 COL6A2 COL6A1 ITGA8 RAPGEF1 COL6A3 ITGA7 ITGA6 PIK3C3 ITGA5 SOS1 CRK SOS2 DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 SRC LAMA1 COL11A1 LAMA4 COL11A2 LAMA3 NTN4 ASAP1 CDC42 MAPK9 NRAS MAPK8 MICALL1 FLNA PTK2B FLNB FYN CSK MAPK6 MAPK3 MAP3K2 MAP3K3 LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 MAPK13 MAPK10 COL3A1 BCAR1 LIMS2 LIMS1 COL16A1 ITGA2B COL12A1 ARAF ARPC5L ACTB CRKL ACTG1 DMBT1 MAP3K4 MAP3K5 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL8A2 COL4A6 ELMO1 COL8A1 COL4A5 ELMO2 RAF1 TLN1 VCL COL17A1 COL13A1 SHC1 PXN ARL1 PIK3R3 PIK3R2 PIK3R1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 BRAF PARVA ARPC5 PARVB ARHGAP26 PTK2 COL1A2 ARPC2 COL5A1 ARPC3 ITGA10 COL5A3 COL5A2 ITGA11 COL9A1 COL20A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ITGB2 ARPC1A PIK3CD ILK LAMC2 LAMC1 ITGAE PIK3CB PIK3C2A ITGAL RND2 RND3 PIK3CG PIK3C2B RND1 RAC2 ITGAX INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway IFNG IFNGR1 STAT1 IFNGR2 JAK2 JAK1 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway IL3RA MAPKAPK2 RAF1 IL6ST SOS1 SOS2 SHC1 SRF IL20RA FOXO3 NRAS MAPK7 CXCR1 MKNK1 CXCR2 MKNK2 STAT4 MAPK1 STAT6 IL12RB1 MAPK6 MAPK3 IL12RB2 STAT5A STAT5B NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 BRAF MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL2RB IL9 IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 ARAF IL5RA IRS2 PIK3CB SLA2 ELK1 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 MYC AKT2 RPS6KA2 RPS6KA1 AKT3 AKT1 IL13RA2 IL6R JAK3 IL13RA1 IL10 IL11 IL15RA IL4R CHUK PDPK1 IL15 IL11RA IL13 IL18 FOS IL1A PIK3CA IL23A IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIN3A VAMP1 SHANK3 VAMP2 VAMP3 SHANK1 GRIA1 GRIA2 SNAP25 GRIK5 STX19 SNAP23 SLC1A1 SLC1A2 GRIK3 SLC1A3 GRIK4 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis HACL2 BCAT1 BCAT2 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway JAK3 JAK1 STAT5A STAT5B STAT1 STAT3 STAT4 STAT6 JAK2 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB GMDS PMM1 PMM2 MPI GMPPA METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GNB3 GNB5 SNAP25 GRIK5 SNAP23 GRIK3 GRIK4 GRIK1 GRIK2 GRM1 GRM5 GNGT2 GRM4 GRM7 GRM6 PRKACG GRM8 PRKACA SNAP29 PRKACB CACNB1 VAMP8 STX1B PRKAR1B PRKAR1A VAMP1 VAMP2 STX1A VAMP3 GRIA1 GRIA2 SLC1A1 GNAI3 SLC1A2 CACNA1B CACNA1A SLC1A3 PRKX SLC1A6 SLC1A7 CACNA1E GNAI1 GNAI2 GNG10 GNG3 GRIN2A GNG5 PRKAR2B GNG4 GNG7 PRKAR2A VTI1A GNG8 SLC17A7 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 ADCY10 GRIN3A GNB2 GNB1 GNB4 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway PRKACA SNAP29 PRKACB GNG11 GNAO1 CACNB1 VAMP8 STX1B ADCY10 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 VAMP1 GNB5 VAMP2 STX1A VAMP3 SNAP25 SNAP23 GNAI3 CACNA1B CACNA1A PRKX CACNA1E GNAI1 GNAI2 GRM3 GRM2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN2D GRIN1 GRM5 GRIN2A PLCB4 GRIN3A PRKAR1B PRKAR1A PRKACG GNA11 GNAQ PRKACA PRKACB GRINA HOMER1 PRKCB GRIK5 ITPR1 GRIK1 PRKX GRIN2C GRIN2B GRM1 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing ZRSR2 SNRNP40 PRPF3 ZRSR2P1 SNRPB2 SNRPA MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PRKCE PRKCD PRKCA GRIN2C GNG11 GRIN2B GRIN2D GRIN1 SLC5A7 PLCB4 GRIN3A GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ PKN2 GNB5 PKN1 CHRM3 CHRM1 PKN3 ITPR1 ITPR2 ITPR3 PRKCZ GNA14 GNG10 GNG3 GRIN2A GNGT2 GNG5 GNG4 GNG7 GNA11 GNG8 SLC18A3 PRKCG PRKCI PRKCH PRKCB MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway ADCY10 SLC5A7 SLC6A8 PRKAR1B PRKAR1A GNB2 GNB1 GNB4 GNB3 GNB5 CHRM2 CHRM4 GNAI3 PRKX GNAI1 GNAI2 GNG10 GNG3 GNGT2 GNAT2 GNG5 PRKAR2B GNG4 GNG7 PRKAR2A PRKACG GNG8 GNAT1 PRKACA PRKACB KCNJ3 SLC18A3 KCNJ5 KCNJ6 KCNJ9 GNG11 GNAO1 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 GFPT2 AMDHD2 GFPT1 NPL NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation INMT UGT2B7 CYP2A7 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 FMO3 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 CHRNA3 CHRNA5 KCNK9 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G GNG2 EPB41L1 EPB41L2 FLNA DRD2 PRKACA DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA GNB1 PPP1R1B KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway NOTCH2 RBPJL JAG2 NOTCH3 NOTCH1 JAG1 MAML1 NOTCH4 RBPJ DLK1 DLL3 DLL4 NCOR2 NUMB CIRSR O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI2 GNAO1 GNG10 GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 AVP GNAI3 OPRK1 OXT ADCY2 PDYN GNG12 ADCY7 GNAI1 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 PENK GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 PDYN GNG12 ADCY7 GNAI1 GNAI2 GNG10 GNG3 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNG3 GNGT2 GNG2 GNG5 GNG4 GNG7 GNB2 GNB1 GNB4 GNB3 GNG8 GNB5 OPRD1 GNAI3 ADCY2 GNG12 ADCY7 GNAI1 GNAI2 POMC GNAO1 GNG10 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAPK12 MAPK13 MAPK9 MAPK11 MAPK8 EEF2K MYC DDIT3 MKNK1 MKNK2 BCL2 MAP2K6 MAP2K3 MAP2K4 JUN MEF2C STAT1 MAX PLA2G4A TXN MAPK14 ELK1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCB4 GNAQ GNB2 GNB1 GNB4 GNB3 PRKCQ GNB5 PLCB1 PLCB2 PLCD4 PLCD1 OXTR PRKCZ GNA14 GNG10 GNG3 GNGT2 GNG2 GNG5 PLCZ1 GNG4 GNG7 GNA11 PLCG2 PLCE1 GNG8 PLCG1 PRKCG PRKCI PRKCH PRKCB PRKCE PLCL1 PRKCD PRKCA GNG12 PLCB3 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 MAP3K7 EIF4E MEF2D MAP3K4 MAP2K6 MAP2K4 MEF2C MEF2B IL1R1 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation AKT2 RPS6KB2 AKT3 EIF4EBP1 AKT1 TP53 TP63 TP73 IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 PPP2CA PPP2CB RPS6KB1 RHEB P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 COP1 MDM2 MDM4 TP53 TP63 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 MAPK13 MAPK11 RBL1 PIK3CA CCNE1 CDK2 CCNG1 CTNNB1 KRAS ATM PIK3C3 TP53 TP73 ATR RB1 CDKN1A PTEN PIK3CD PIK3R3 PIK3R2 PIK3C2G TPTE PIK3R1 PIK3CB PIK3C2A PIK3CG PIK3C2B PIK3R5 PPP2CA PPP2CB NRAS AKT2 AKT3 AKT1 HRAS TP63 PDPK1 SIAH1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway CREBBP GADD45B PDPK1 GADD45A CDKN2A TRAF2 CDC25C SIRT1 PML GADD45G KAT2B PIK3CA CCNE1 KAT6B CDK2 CDK1 MDM2 MDM4 ATM TP53 TP73 ATR CDKN1A HDAC1 PTEN TPTE HMGB1 CCNB1 WRN SUMO1 SIN3A CHEK2 AKT2 SUMO3 SUMO2 AKT3 AKT1 EP300 SFN MTA2 GTSE1 TP63 CDKN2D PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK1 SFN NDUFV2 YWHAG MAPK3 SNCA YWHAH GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 CASK SEPTIN4 GPR37L1 MAPK14 SNCAIP YWHAZ MAPK15 MAPK12 PSMA5 MAPK10 PSMA6 PSMA3 PSMA4 CCNE2 TH PSMA1 CCNE1 PSMA2 PRKN YWHAE STX12 YWHAB ELK1 PSMA7 PSMB10 SLC6A3 PLD2 PSMA8 MAPK9 PSMB7 MAPK8 MAPK7 YWHAQ PSMB3 PSMB1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARAF ETS1 ELK1 RPS6KA4 ELK4 RPS6KA3 ARHGAP42 RPS6KA6 RPS6KA5 OPHN1 GRAP2 MYC AKT2 RPS6KA2 RPS6KA1 MAP3K4 PDGFRB PDGFRA MAP2K1 MAP2K2 PRKCA PDGFRL MAPKAPK2 ERF ERG RAF1 SHC2 SHC3 SHC1 PDGFB ITPR1 PDGFA ITPR2 PIK3R3 PIK3R2 ITPR3 PIK3R1 ARHGAP15 ARHGAP12 PIK3R5 PLCG2 SRGAP3 PLCG1 SRGAP1 STAT5A STAT5B JUN BRAF ARHGAP26 FLI1 FEV GRB2 GRAP ARHGAP9 GSK3B GSK3A ARHGAP8 ARHGAP1 PIK3CD PIK3CB ARHGAP5 ARHGAP6 PIK3CG RERG ARHGAP4 IKBKB NCK2 JAK2 HRAS JAK3 NINL GABPA NCK1 JAK1 VAV3 RASA4B CHUK PDPK1 GAB1 FOS GAB2 ETV3 VAV1 VAV2 ARHGAP10 ELF1 ELF2 PIK3CA ELF3 RASA4 ELF4 RASA1 ELF5 RASA2 PIK3C3 SOS1 SOS2 MYCBP SRF NRAS MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 STAT4 MAPK1 STAT6 MAPK6 SPDEF MAPK3 MAP3K2 STAT1 STAT2 STAT3 ELP1 USF2 MAPK15 RAB11B MAPK10 NIN RPS6KB1 RPS6KB2 PKN2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 TKT PGD HK2 HK1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 INSR YWHAZ RPS6KB1 PIK3CA GNAQ GNB2 GNB1 RPS6KB2 GNB4 GNB3 GNB5 SOS1 SOS2 GSK3B PTGER1 IRS1 GNAI3 PIK3R3 PIK3R2 PIK3R1 PIK3CB FOXO4 FOXO3 GNAI1 FOXO1 GNAI2 PIK3R5 CASP9 GNGT1 GNA14 NRAS GNGT2 GNAT2 GNA11 AKT2 AKT3 AKT1 PDPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGB FGA SERPINB2 MMP1 FGG SERPINE1 MMP3 SERPINF2 PLAUR PLG PLAT MMP9 MMP13 PLAU LPA PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD DPYSL3 ABAT UPB1 CDA NT5E ALDH6A1 DPYSL5 DPYS DPYSL2 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism PKLR ME1 PCK1 CLYBL CS ACLY PDHA2 PDHA1 PC PKM RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway STAT3 BRAF MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS GRB2 RGL1 ATF2 GSK3B GSK3A ARAF MAP3K7CL PIK3CD PIK3CB ETS1 ELK1 PIK3CG RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 RAC2 AKT1 RAC3 RAC1 HRAS MAP3K4 MAP2K3 MAP2K4 MAP2K1 MAP2K2 PDPK1 RHOC RHOA RHOB TIAM1 PIK3CA MAPKAPK3 MAPKAPK2 PIK3C3 RAF1 SOS1 SOS2 EXOC2 RALA RALB SHC1 SRF PLD1 PLD2 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 MAP2K7 PAK3 RALGDS PAK2 MAPK3 MAP2K6 JUN MAP3K1 STAT1 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MTR MAT1A SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides CDA TK1 ADAT2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPRT UPP1 ADAT2 UCKL1 UCK2 UCK1 NME2 NME3 NME4 UPP2 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SYT6 STX1B RIMS1 SYT12 SYT11 VAMP1 STX2 STX1A SYT5 UNC13B SNAP25 UNC13C SYT3 RAB3A SYT2 SYT1 STXBP1 SYT15 SYT7 UNC13D TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle SUCLG1 SDHC ACO2 PDK2 CS FH PDHA2 PDHA1 MDH1 OGDH T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation CD86 CD80 ARAF PIK3CD CD3G PIK3CB CD3E CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC GRAP2 AKT2 AKT3 NCK2 AKT1 RAC1 HRAS NCK1 VAV3 MAP2K1 MAP2K2 CHUK FOS VAV1 VAV2 ZAP70 PIK3CA LCK PRKCQ LCP2 PIK3C3 RAF1 SOS1 SOS2 ITPR1 PIK3R3 PIK3R2 PIK3R1 CDC42 MAPK9 NRAS MAPK8 PAK1 MAPK1 PLCG1 PAK3 PAK2 MAPK3 JUN MAP3K1 BRAF NFKBIA PTPRC CD28 CD247 CALM1 LAT TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis DHFR DHFR2 GCH1 FPGS TYMS TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway SMURF1 BMP8A GDF2 SMAD9 GDF1 BMP8B INHBB INHBA GDF3 SMAD6 MAPK14 GDF6 BMP7 GDF5 INHBC ACVR2B SMAD5 BMP6 ACVR2A MAPK12 SMAD7 MAPK13 BMP5 INHBE GDF7 BMP4 SKI FOSL1 MAPK10 GDF9 BMP3 MAPK11 BMP2 BMP1 GDNF TLL2 TLL1 TAB1 BMPR1B NODAL BMPR1A DCP1B ACVRL1 ATF2 BMP10 BMPR2 MSTN AMHR2 CITED1 CITED2 MAP3K7CL BMP15 EP300 SNIP1 MAP3K7 HRAS JUNB ACVR1 LEFTY1 FOXH1 TGFBR1 TGFBR2 ACVR1B MAPK9 NRAS MAPK8 ACVR1C RRAS MAPK1 LEFTY2 SKIL MAPK3 GDF10 SMAD2 GDF11 SMAD1 JUN TGFB2 SMAD4 CREBBP JUND SMAD3 SMURF2 TGFB3 GDF15 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway SNAP25 SNAP23 TRH GNGT2 PLCZ1 PLCE1 SNAP29 TSHB PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA TRHR CACNB1 VAMP8 CACNB2 CACNB3 PLCB3 CACNB4 PLCB4 VAMP1 PRKCQ PLCB1 PLCB2 VAMP2 VAMP3 CACNA1B CACNA1A PRKCZ CACNA1E GNA14 GNG10 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 PLCG2 GNG8 PLCG1 STX3 CGA PLCL1 GNG12 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 PLCD4 PLCD1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway TLR8 TLR10 TLR7 TAB1 TLR6 NFKBIE TLR4 TLR3 MYD88 TLR2 ECSIT ELK1 TANK IKBKB MAPK9 MAPK8 TBK1 IRAK1 MAP3K8 MAP3K7 IKBKE MAPK3 MAP2K3 JUN MAP2K1 MAP2K2 TICAM2 CHUK IRAK4 MAPK14 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TRAF6 TLR9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L GTF2A1L CREBBP TBP BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 PRKAR1B PRKAR1A TBPL2 TAF8 TBPL1 TAF7 TAF6 TAF4 TAF2 CREB5 GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 PRKAR2B TAF1C CREB3L4 PRKAR2A POLR2C CREB3L1 CREB3L2 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2D4 UBA6 UBE2D2 UBE2D3 UBE2D1 UBE2L6 UBE2L3 UBE2NL ATG7 UBE2B UBE2C UBE2E3 UBE2E1 UBE2E2 UBE2G1 UBE2A UBE2G2 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 UBE2K VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis HACL2 BCAT1 BCAT2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis OXT AVP VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRR5 ARHGAP8 TGFB1I1 ARAF ARHGAP1 PIK3CD HSPB1 PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 RAC2 KDR AKT1 RAC3 RAC1 HRAS PRKCG PRKCI MAP2K1 PRKCH MAP2K2 PRKCB SPHK2 PRKCE SPHK1 PRKCD PLA2G4A PRKCA PIK3CA MAPKAPK3 PRKD3 MAPKAPK2 PRKCQ PIK3C3 PRKD2 PRKD1 CRYAA RAF1 CRYAB SHC2 SH2D2A PXN PIK3R3 PIK3R2 PIK3R1 PRKCZ HIF1A NRAS PLCG2 LPXN MAPK1 PLCG1 MAPK3 NOS3 BRAF MAPK14 PTK2 VEGFA VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway RXRA VDR RARA F13B GC WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway SMARCAL1 SMARCB1 FZD10 ARR3 BTRC PRKCG PRKCI SMARCC1 PRKCH SMARCC2 PRKCB PRKCE CSNK2A3 CSNK2A2 PRKCD PRKCA CSNK1D CSNK1E CSNK2B PRKCQ SRCAP PCDH10 PCDH15 PCDH12 PCDH19 NLK PRKCZ PCDH18 GNG10 PPP3R1 PPP3R2 PCDHA1 HLTF PCDHA5 PCDHA4 PCDHA3 PCDHA2 PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B CREBBP WNT10A FZD3 FZD2 FZD5 FZD4 SIAH2 FZD7 PCDH20 FZD6 SIAH1 FZD9 SMARCA5 NFATC3 NFATC2 FZD8 NFATC1 INO80 SMARCA1 GNG12 SMARCA2 SMARCA4 NFATC4 GNG13 PCDHGA10 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 FAT1 PCDHB6 FAT2 PCDHB5 FAT3 DCHS1 PCDHB4 PCDHB3 PCDHB8 PCDHB7 PPP3CA PPP3CB PPP3CC ANKRD6 HELLS WNT9B KREMEN1 WNT9A KREMEN2 PLCB3 PLCB4 PLCB1 PLCB2 WNT8A WNT8B FSTL1 PPP2CA PPP2CB CTNNA1 TBL1Y CTNNA3 TBL1X CTNNA2 CSNK1A1 WNT7B PCDHB15 WNT7A PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 PCDHB16 CTNNB1 PCDH11Y PCDH11X CELSR1 CELSR2 CDH9 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH3 CDH2 CDH1 EP300 PCDHAC2 PCDHAC1 TLE4 TLE3 CSNK1G3 TLE2 TLE1 WNT5B FBXW11 WNT5A CHD1L PCDHA13 PCDHA12 PCDHA11 TLE6 PCDHA10 PYGO1 PYGO2 TBL1XR1 CSNK1G2 ITPR1 ITPR2 ITPR3 WNT6 CDH20 DVL1 CDH22 DVL2 EP400 CDH23 CDH24 DVL3 WNT1 WNT2 WNT3 WNT4 SMAD1 SMAD4 WNT3A SMAD5 BCL9 GNAQ GNB2 GNB1 GNB4 GNB3 GSK3B PCDHGB7 WNT2B PCDHGB6 PCDHGB4 PCDHGB2 ARRB1 ARRB2 PPP2R5E DACT1 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A WNT16 CDHR1 CDH10 CDH11 CDHR2 SAG CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 SMARCD1 HDAC2 SMARCD2 HDAC3 SMARCD3 HDAC1 LEF1 LRP5 HDAC8 LRP6 GNA14 GNG3 WNT11 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PCDH1 CTNNAL1 SMARCE1 TCF7L2 TCF7L1 PCDH9 PCDHGC5 PCDH7 PCDHGC4 PCDH8 PCDHGC3 CSNK1A1L XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway PNP GDA HPRT1 PRTFDC1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC AARS2 MPC1 GPT AGXT ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 PLA2G4B FADS1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MARS1 METTL6 SLC39A8 SCLY MAT2B GGT1 SEPHS2 PAPSS1 AHCY MAT2A CBS CTH AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLDC GLS2 AQP8 AMT ASNS PIG59 DLD ASRGL1 GLUD1 HAL SDS CPS1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism BHMT AHCY MAT2A CHDH PEMT MTR MAT2B ALDH7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HMGCL ECHS1 OXCT1 ACSM1 HADH ACADS ACAT1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2C9 CYP2C8 CYP2A6 NAT2 CYP1A2 CYP2E1 CYP3A4 XDH CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SHMT1 SETD7 BBOX1 ALDH9A1 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides CAT TYRP1 SOD2 SOD3 SOD1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ALDH2 ALDH1B1 ADH1B CAT CYP2E1 ACSS1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GPD1 GAPDH HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS CTH KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 OXCT1 ACAT1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 GOT2 SLC25A12 SLC25A11 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PANK1 PPCS ENPP1 COASY PPCDC PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 GLYAT ACSM2B PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism FLAD1 RFK ENPP1 TYR ACP1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2A ODC1 AMD1 SMS MAT2B SRM TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 GAD1 CDO1 ADO CSAD UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1 GPT2 SLC2A2 GPT SLC1A4 SLC2A4 SLC25A22 SLC38A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 NQO1 GGCX PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDS1 DGKA CHAT GDE1 AGPAT1 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 CDIPT LYPLA1 PLA2G2D PCYT1A CHKA PLA2G4B CRLS1 PISD PLA2G15 PHOSPHO1 GPAM GPD2 GPD1 PEMT PLPP1 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO ALPL AOX1 PDXP PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC AARS2 MPC1 GPT AGXT PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC AARS2 MPC1 GPT AGXT 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ADSL GAD1 CAD ASNS ABAT ASS1 DARS1 ASRGL1 DDO IL4I1 NARS1 ASL ADSS1 ASPA SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia AMDHD1 CARNS1 HARS1 AOC1 CARNMT1 MAOA HDC PRMT3 HNMT HARS2 FTCD CNDP1 CNDP2 ALDH3A1 HAL ALDH2 UROC1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC AARS2 MPC1 GPT AGXT LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) TAT FAH YARS1 FARSA HPD FARSB GSTZ1 IL4I1 GOT1 HGD PAH REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 PHYH ABCD2 HACL1 SLC27A2 ABCD1 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A10 GGT1 PTGDS CBR1 PDIA2 GPX1 PTGIS UGT1A1 PLA2G4B CYP4A11 PDIA6 PDIA4 CYP2U1 DNAJB11 ERP29 UGT2B4 CYP2E1 PPIB UGT2B7 PTGES SLC22A6 ALOX15 ALOX12B ALOX12 CYP3A4 CYP2C19 PTGS2 LTC4S PTGS1 HSP90B1 CYP2B6 ALOX5 UGT1A3 LTA4H UGT1A9 CYP2J2 SDF2L1 HSPA5 EPHX2 CYP4F2 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 CYP2C8 PRXL2B TBXAS1 HYOU1 SLC22A8 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES UGT1A10 ADH1B ADH1A ALOX15 ALOX12B ALOX12 CYP3A4 PTGS2 LTC4S PTGS1 CYP2B6 CYP2D6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C9 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 INPP4A MINPP1 PIKFYVE IMPA1 PIK3CA PTPMT1 ITPKA PI4KA INPP5J PIK3C3 PLCD3 IPPK VAC14 BECN1 MIOX ISYNA1 INPP1 ITPK1 IPMK PIK3R4 AMBRA1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NNMT QPRT NMNAT2 NT5C2 NADSYN1 BST1 PNP NNT NMRK1 NAMPT ENPP1 AOX1 NADK NUDT12 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria SLC25A11 ACLY PDHA1 PC MDH1 MPC1 ME1 PDHB OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids HACL1 SLC25A20 ABCD1 CRAT PEX13 PEX14 PHYH ABCD2 ALDH2 CPT2 ACSL1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 ITPK1 IPMK NUDT3 INPP4A INPP4B MINPP1 IMPA1 PPIP5K1 ITPKA INPP5J IP6K1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism CAT AFMID CYP1A1 IDO1 TPH1 DDC AADAT HAAO ASMT KMO INMT WARS1 ACMSD WARS2 AANAT ALDH2 TDO2 KYNU RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5F1A ATP5F1B GPD2 UQCRC1 CYCS SLC37A4 GAPDH SLC25A4 MT-CO1 ATP5PB NDUFA1 ATP5MC2 SDHC SDHD SDHA ATP5F1C SDHB ATP5F1D ATP5F1E MT-ATP6 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA SDS PCCA PCCB DBT BCKDHB MMUT DLD FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation TREH ATP1A4 ATP1B4 SLC2A2 ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 GCK FXYD2 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis GNPAT AGPS CEPT1 AGPAT1 PLPP1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADHB HADHA ECHS1 ACAA2 ACSM1 SLC25A20 ACADM HADH MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL ACSL1 SLC25A20 HADH HADHB HADHA CPT1A ECHS1 ACAA2 CPT2 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) TYMS NT5C2 UPB1 TYMP DHODH UCKL1 DCTD NME6 RRM2B DPYD CMPK2 UPP2 TK1 ITPA CDA DUT RRM2 CANT1 GDA DPYS CAD AK3 CTPS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GLS2 GOT2 GPT SLC1A4 SLC1A5 ASS1 GLUD1 SLC25A15 CPS1 ASL SLC25A12 OTC CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GLB1 GAA AKR1B1 LCT GLA G6PC1 PGM1 HK1 GALE GALT B4GALT1 UGP2 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1A3 ATP1A2 ATP1B3 ATP1A1 SLC5A1 ATP1B2 ATP1B1 LCT FXYD2 ATP1A4 ATP1B4 SLC2A2 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency CYP2A7 CYP2A6 DHRS9 ALDH1A2 ALDH1A1 DNAJB11 ERP29 PNPLA4 HYOU1 PPIB RETSAT RDH8 ADH1A CYP3A4 CYP3A5 CYP3A7 HSP90B1 CYP2B6 CYP2A13 AWAT1 RDH12 RDH11 RDH16 LRAT BCO1 PDIA2 SDF2L1 DGAT1 HSPA5 UGT1A1 CYP3A43 PDIA6 DHRS3 RPE65 PDIA4 DHRS4 CYP26A1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) UGT2B11 ALAS1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 GUSB BLVRA COX10 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 KDR VEGFA VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway ABCC1 TUBA1B ABCB1 ABCC2 TUBB1 SLCO1B3 ABCG2 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway ABCC2 TUBB1 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ABCB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway ABCB1 ABCC2 TUBB1 CYP3A4 ABCC10 TP53 ABCC3 ABCC1 CDKN1A TUBA1B RALBP1 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCB1 EGFR ABCG2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 PLA2G2A CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway ACE AGTR1 REN AGT IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway ACE GNG2 GNAQ GNB1 AGTR1 REN AGT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway rplS CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D CYP3A4 CYP2C19 CYP3A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 SERPINC1 F12 FGG F11 F13A1 PLG PLAT ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway rplS CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway rplS CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway rplS ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway rplS ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway rplS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway rplS AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway rplS GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway rplS KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway rplS NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway rplS NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway rplS SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway rplS STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway rplS DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway rplS DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway rplS MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway rplS OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway rplS TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway rplS LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway rplS ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway KCNIP2 EPHX1 CYP2C9 DLG1 FXYD2 CYP1A2 HYOU1 KCNK1 SNTB1 SNTB2 CHRM2 RYR2 ATP2A2 COMT SLC8A1 SCN5A PRKACA SNTA1 KCNH2 PDIA2 UGT1A1 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 PDIA6 PDIA4 CACNB1 PRKAR1A KCNQ1 DNAJB11 ERP29 CYP2E1 PPIB ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CYP2C19 CACNA1H CACNA1G HSP90B1 PLN UGT1A4 UGT1A9 KCNJ2 UGT1A6 KCNJ3 KCNJ4 NQO1 KCNJ5 SDF2L1 HSPA5 KCNJ11 KCNJ8 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 SCN5A PRKACA SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CYP3A4 CACNA1H CACNA1G PLN KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 CYP1A2 KCNK1 SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway CACNA1G PLN SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C ADRA1A CACNA1H SLC8A1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway GRIN3A FXYD2 UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway CHRNB2 PDIA2 SDF2L1 HSPA5 UGT1A1 KCND2 KCNIP2 UGT2B15 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 PDIA6 PDIA4 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DNAJB11 ERP29 UGT2B4 HYOU1 PPIB UGT2B7 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 HSP90B1 GRIN2A UGT1A3 DRD1 UGT1A8 SCN1B METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2C8 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2B6 CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CACNB1 SCN10A GRIN3A FXYD2 CYP1A2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PCSK2 MAOB MAOA CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP2C19 SLC6A2 ADRA1A SLC6A3 CYP3A7 SLC6A4 GRIN2A CYP2D6 AOX1 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway GRIN1 POMC CACNB1 CYP2C9 SCN10A GRIN3A FXYD2 PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 CYP3A4 CYP2C19 CYP3A5 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2D6 DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway PPAT AOX1 RAC1 PRPS1L1 XDH ATAD1 ABCC4 GUCY1A2 RRM1 ADSL RRM2 ABCC5 ENTPD5 PDE4D AMPD1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 SLC28A2 SLC29A1 GART ADA ITPA SLC29A2 SLC28A3 GUCY1B1 TPMT GDA AK1 GMPS ADK GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway ATP1B2 FMO3 OPRM1 ATP1B1 GRIN1 POMC CACNB1 CYP2A6 SCN10A GRIN3A FXYD2 PCSK2 CHRNA3 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A CYP2B6 UGT1A4 AOX1 DRD1 UGT1A9 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 ALDH2 ALDH1B1 DCT CAT CYP2E1 ACSS1 PNMT AOC1 DDC ACSS2 GOT1 HGD ADH1B MAOA ADH1A NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 INS PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System GNAS ADCY2 DRD1 PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 CREB1 GNB1 GNAS HTR4 PRKACB ESR1 PPP1CA CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production POMC GNGT1 MC2R GNB1 GNAS PRKACB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin GNGT1 CREB1 HTR7 GNB1 GNAS PRKACB ESR1 PPP1CA EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin GNGT1 HTR6 CREB1 GNB1 GNAS PRKACB ESR1 PPP1CA INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine NFKBIA MAPK11 CREB1 ADORA2A PIK3CA GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF NFKB1 NFKB2 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine NFKB1 NFKB2 NFKBIA MAPK11 CREB1 PIK3CA ADORA2B GNB1 GNAS RAPGEF2 ARHGEF7 RAPGEF3 ATF2 ADCY2 ELK1 PRKCZ IKBKB CDC42 GNGT1 MAPK8 PAK1 RAP1A PARD6A RPS6KA1 MAPK1 AKT1 MAP2K7 HRAS PRKACB MAP3K4 MAP2K6 JUN MAP2K2 MAP3K1 CHUK PDPK1 BAD BRAF VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis GNGT1 FSHR AVPR2 GNB1 GNAS ADCY2 GNG12 PRKACB INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 CGA GNG12 PRKACB ESR1 PPP1CA GNGT1 CREB1 FSHR GNB1 GNAS INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ESR1 PPP1CA GNGT1 CREB1 HRH2 GNB1 GNAS ADCY2 PRKACB INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin GNAS ADCY2 CGA PRKACB ESR1 PPP1CA GNGT1 LHCGR CREB1 LHB GNB1 INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 GNGT1 GNB1 GNAS ADCY2 PRKACB PTGDR INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin GNGT1 PTGIR MYL3 GNB1 GNAS ADCY2 PRKACB MYLK FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K2 SYK IL13 PLA2G4A PRKCA GAB2 MAPK14 IL4 IL3 IL5 PIK3CA BTK IGHE KRAS GRB2 LCP2 RAF1 MS4A2 SOS1 LAT CSF2 PIK3R1 TNF NRAS MAPK8 INPP5D FCER1A MAPK1 AKT1 FYN PLCG1 RAC1 MAP2K7 HRAS MAP2K6 PDK1 LYN MAP2K3 VAV3 MAP2K4 MAP2K1 FCER1G INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling MAPK1 AKT1 GRB2 RAF1 SOS1 HRAS MAP2K1 MAP2K2 PDPK1 SHC1 IRS1 INSR IRS2 SLC2A4 PIK3CG FOXO1 PIK3R6 INS MAPK8 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency DHFR QDPR GCHFR CBR1 GCH1 SPR AKR1B1 PTS CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 CNDP1 AOC3 ALDH6A1 ALDH2 DPYS GAD1 DPYD ABAT TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE GALT UGP2 UXS1 GCK PGM1 GALK1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSTO2 ANPEP GSS GSR OPLAH GCLM GGCT GCLC CASP7 GPX1 GGT6 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency ACSS1 DLD HIBCH LDHAL6B BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT MLYCD ACADM HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO ALPL AOX1 PDXP CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency EPRS1 CPS1 P4HA3 ASL CKB NOS1 PRODH OTC GAMT RARS2 OAT GOT1 ARG1 PYCR2 ASS1 ALDH4A1 GLUD1 SLC25A15 GATM DAO CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LIPA LSS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS CTH HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS CTH ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency ABCD1 CRAT PEX13 PEX14 ABCD2 CPT2 ACSL1 SLC25A20 CROT PEX11G GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD RPE TALDO1 PGD DERA RPIA PFKL PGLS ALDOA PRPS1L1 TKT FBP1 PGM1 RBKS 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia ECHS1 ACAA2 HIBADH ABAT HSD17B10 ACAT1 HMGCL ALDH2 AUH OXCT1 DBT AOX1 ACADM HMGCS2 ACADS HIBCH BCKDHA MCCC2 ACAD8 BCKDHB MCCC1 ACADSB ALDH6A1 PCCA IVD PCCB BCAT1 DLD FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease UGT8 ACER1 NEU3 SGPL1 SPTLC1 SPTLC2 GLB1 ACER3 KDSR DEGS2 B4GALT6 GLA PLPP1 ENPP7 ARSA GAL3ST1 SGMS1 CERK SPHK2 GBA1 SGPP2 GALC UGCG HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 LPL AKR1B1 AGPAT1 PLPP2 PLPP1 ALDH3A1 LIPC GPAM GPD2 GLYCTK GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT2B1 SULT1A1 CHST11 BPNT1 SUOX PAPSS2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) PNMT AOC1 DDC GOT1 HGD MAOA ADH1A HAAO DBH MIF TYR FAH COMT GSTZ1 ALDH3A1 DCT G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease NANS GNE CMAS HEXA GFPT1 UAP1 NPL RENBP HK1 CHIT1 NANP GNPDA1 NAGK AMDHD2 PGM3 SLC17A5 GNPNAT1 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency PAICS APRT PDE10A NME6 IMPDH1 HPRT1 ADSS2 GART ADA ITPA GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK PNP ATIC GUK1 PPAT PRPS1L1 XDH ATAD1 GUCY1A2 RRM1 ADSL RRM2 ENTPD5 PDE4D AMPD1 ENTPD8 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HADHB HADHA ECHS1 ACAA2 MECR PPT1 HSD17B10 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency GCDH ACADVL CPT1A ECHS1 ACAA2 ACSL1 ACADSB ACAT1 HADHB HADHA CPT2 ACADL ACADM ACADS CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) CS PC MPC1 IDH3B SUCLG2 SUCLG1 DLAT ACO2 DLD IDH3A FH PDHA1 MDH1 IDH3G DLST SDHC SDHD PDHB SDHA SDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI MGAM UGT2B11 AGL GBE1 AMY1C PYGL GCK HK2 PGM2L1 GYS2 UGDH UGP2 SI GUSB PGM1 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA PC ALDH2 LDHD ME1 DLAT HAGH PCK1 DLD PDHA1 ACSS2 PKLR MDH1 GLO1 ACOT12 AKR1B1 ACYP1 PDHB ACACA ACAT1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SRD5A1 HSD17B1 HSD3B1 AKR1D1 HSD17B3 UGT2B17 CYP19A1 CYP17A1 SULT2B1 UGT2B11 STS SULT1E1 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ALDH4A1 GLUD1 GCLC ALDH5A1 NAGK CPS1 QARS1 PPAT GNPNAT1 PIG59 GCLM EARS2 GLS2 GSS GAD1 GSR GOT2 CAD GFPT1 GMPS GPT ABAT SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACSS3 ECHS1 ACAA2 ACADL HADH ACADS HSD17B10 ACAT1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 OXCT1 ACAT1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS CTH CHDH MSRB2 MSRB3 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PKLR PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK2 PGK1 GALM ALDOA GAPDH PFKM GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome NME2 CMPK1 LALBA G6PC1 SLC35A2 GALT B4GALT1 UGP2 CANT1 SLC2A1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease HK2 LDHA PC MPC1 GALM SLC37A4 ALDOA PCK1 GAPDH FBP1 SLC25A11 PGM1 GPI TPI1 MDH2 PANK1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR FIG4 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A COAGULATION%SMPDB%SMP0000586 Coagulation F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2 PDIA6 PDIA4 PTGS1 HSP90B1 CYP2C9 CYP2C8 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 UGT1A9 PPIB SLC22A8 UGT2B7 PDIA2 UGT1A10 SLC22A6 SDF2L1 HSPA5 UGT1A1 CYP3A4 CYP2C19 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1 CYP3A4 CYP3A5 PDIA6 PDIA4 HSP90B1 SLCO1B1 DNAJB11 ERP29 HYOU1 TOP1 UGT1A9 PPIB CES2 CES1 ABCG2 BCHE PDIA2 UGT1A10 ABCC1 ABCB1 ABCC2 SDF2L1 HSPA5 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PDIA6 PDIA4 PTGS1 HSP90B1 DNAJB11 ERP29 HYOU1 PPIB ABCC3 TOP2A TOP2B PDIA2 ABCB1 SDF2L1 HSPA5 UGT1A1 CYP3A4 PTGS2 MPO CYP3A5 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway TOP2A CYP3A4 MPO CYP3A5 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 RRM2 CTPS1 TYMS DCK NME1 DCTD NT5C RRM2B CMPK1 SLC29A1 SLC28A1 SLC28A3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway CYP3A4 CYP2C19 CYP2C9 ALDH3A1 CYP2C8 CYP2A6 GSTM1 CYP2B6 ALDH1A1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway CYP2C9 ALDH3A1 CYP2C8 CYP2A6 CYP2B6 ALDH1A1 CYP3A4 CYP3A5 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway FMO3 CYP3A4 ESR1 CYP3A5 SULT1A1 UGT1A10 CYP2B6 CYP2D6 UGT1A4 FMO1 CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CDA TYMS SLC28A1 TYMP CES1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 TPMT ABCC5 GMPS ADK IMPDH1 PPAT AOX1 HPRT1 RAC1 SLC28A2 SLC29A1 XDH SLC29A2 SLC28A3 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP2C19 CYP3A5 P2RY12 CYP2C9 ABCB1 CYP2B6 CYP1A2 PON1 CYP3A4 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SCN5A SNTB1 SNTA1 SNTB2 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA2D2 CACNA1C LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN10A CYP1A2 CYP3A4 SCN1B CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6 OPRM1 CYP3A4 UGT2B7 MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A8 UGT2B7 PDIA2 SDF2L1 HSPA5 UGT1A1 UGT2B15 OPRM1 PDIA6 PDIA4 HSP90B1 DNAJB11 ERP29 UGT2B4 UGT1A3 HYOU1 PPIB HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP3A4 CYP2C19 CYP3A7 GRIN1 CYP2C8 GRIN2A CYP2B6 GRIN3A CYP2D6 OPRM1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 SLC6A2 SLC6A4 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6 SLC6A2 SLC6A4 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOB CYP2D6 MAOA AOX1 CYP2C19 CYP3A7 SLC6A4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway FMO3 UGT1A9 CHRNB2 CYP2A6 CHRNA3 CYP2B6 CHRNA4 UGT1A4 AOX1 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway AK1 NME2 AK2 NME1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway AK1 NME2 AK2 NME1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 ADH1A CYP2E1 CYP3A4 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway CYP2C8 CYP2B6 EPHX1 CYP3A4 CYP2C19 CYP3A5 CYP3A7 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway IVD EHHADH ACSM1 UGT1A3 ACADSB HSD17B10 HADHB CYP2C9 HADHA CYP2A6 CYP2B6 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6 CYP3A4 CYP2C19 SLC6A2 SLC6A4 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2B6 ABCC2 CYP2D6 SLC22A1 CYP3A4 UGT1A8 UGT2B7 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6 CYP1A2 CYP3A4 CYP2C19 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway ABCB1 GSTP1 GSTT1 CYP3A4 HSP90B1 SULT1A1 SULT1E1 CYP2D6 UGT1A9 SULT1A4 UGT1A6 SULT2A1 ABCC4 PDIA2 ABCC1 SDF2L1 HSPA5 UGT1A1 ABCC5 UGT2B15 PDIA6 PDIA4 CYP2A6 CYP1A2 DNAJB11 ERP29 HYOU1 CYP2E1 PPIB ABCG2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2C9 CYP2D6 CYP1A2 CYP3A4 CYP2C19 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2C9 UGT1A10 CYP2B6 CYP2D6 ALDH1A1 CYP3A4 ABCC10 CYP3A5 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2C9 UGT1A10 ADH1B CYP2D6 ADH1A CYP3A4 PTGS2 PTGS1 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2C9 CYP2D6 CYP3A4 CYP2C19 CYP3A5 SLC6A4 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 SDF2L1 HSPA5 UGT1A1 CYP3A4 PDIA6 PDIA4 HSP90B1 CYP2C9 CYP2C8 CYP2B6 DNAJB11 ERP29 HYOU1 UGT1A9 PPIB LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway PGK1 CMPK1 CHPT1 ABCG2 ABCC3 ABCC4 SLC22A3 ABCC1 ABCB1 PCYT1A ABCC2 PCYT2 SLC22A2 SLC22A1 DCK NME1 SULT1A1 NT5C DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 NQO1 CBR1 ABCC1 RALBP1 ABCB1 ABCC2 NOS3 AKR1A1 AKR1C3 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT1A9 CYP3A4 CYP3A5 UGT2B7 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway ABCB1 ABCC2 CYP3A4 CYP3A5 SLCO1B1 CYP2C8 IMPDH1 IMPDH2 SLCO1B3 UGT1A9 UGT1A8 CES2 UGT2B7 UGT1A7 CES1 ABCG2 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9 SLCO1B1 CYP2C8 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PDHA1 SLC16A1 PKLR MDH1 IDH3G IDH1 PGAM2 TALDO1 SDHC SDHD SDHA PGD SDHB CS RPIA GLUD1 PFKL PC PKM SUCLG2 ACO1 SUCLG1 ALDOB ACO2 TKT GAPDH DLD GPI FH GLS2 SLC2A2 DLST ENO1 PDHB SLC1A5 HK2 DHTKD1 LDHA MPC1 IDH3B PGK1 PGLS DLAT IDH3A G6PD PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FGB VKORC1 FGA F10 F12 FGG F11 F13A1 PLG PLAT F2 F3 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 RYR2 ATP2A2 SLC8A1 PRKACG SCN5A PRKACA PRKACB SNTA1 KCNH2 ABCC8 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 PRKAR1B PRKAR1A KCNQ1 ALG10B HCN4 KCNE1 KCNE2 ATP1A4 ATP1A3 UQCR11 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H CACNA1G SLC9A1 PLN PRKAR2B PRKAR2A KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ11 KCNJ8 KCNIP2 DLG1 FXYD2 GNAS KCNK1 SNTB1 MCU SNTB2 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway SCN5A PRKACA KCNJ2 KCNJ3 SNTA1 KCNJ4 KCNH2 KCNJ5 KCNJ11 KCNJ8 ABCC8 KCNIP2 KCND3 TPM2 TPM1 ATP1B4 CACNA2D2 ABCC9 ATP1B3 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FXYD2 KCNK1 ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE1 KCNE2 ATP1A4 ATP1A3 ATP2A2 ADRB1 KCNA5 ATP1A2 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PLN TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling IRS1 INSR TSC2 TSC1 IRS2 MTOR PIK3CG PIK3R6 INS SLC7A5 RPS6KB1 RHEB EIF4EBP1 AKT1 EIF4E LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ATP1A4 CACNA1A ATP1A3 ATP1A2 ATP1A1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B CHRNB2 KCND2 KCNIP2 HTR1A ATP1B4 OPRK1 CACNA2D2 ATP1B3 ATP1B2 OPRM1 ATP1B1 GRIN1 POMC CACNB1 SCN10A GRIN3A FXYD2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway ALOX15 ALOX12B ALOX12 PTGS2 LTC4S PTGS1 CYP2B6 ALOX5 LTA4H GGT1 PTGDS CYP2J2 CBR1 GPX1 PTGIS PLA2G4B EPHX2 CYP4F2 CYP4A11 CYP4F3 AKR1C3 CYP4F8 ALOX15B CYP2C8 CYP2U1 PRXL2B TBXAS1 CYP2E1 PTGES TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway rplS TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway rplS ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway rplS PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway rplS METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB NOX4 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency CYP11B2 CYP11B1 HSD3B1 AKR1D1 AKR1C4 CYP17A1 HSD11B1 HSD11B2 HSD3B2 CYP11A1 CYP21A2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria GCDH ECHS1 SLC25A2 AADAT DLST PIPOX SLC7A2 ACAT1 DHTKD1 HADH DLD ALDH7A1 AASS 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency ACOX2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 AKR1C4 CYP7B1 BAAT CYP46A1 CYP7A1 LIPA CYP8B1 CYP27A1 CYP39A1 CH25H AMACR SCP2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GLYCTK AMT GCAT GNMT GARS1 SARS1 GATM SRR ALDH2 PSAT1 CTH SARDH PHGDH AGXT DLD PSPH GAMT DMGDH ALAS1 SDS MAOA GLDC SHMT2 SHMT1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CARS1 CDO1 MPST LDHA GCLC GOT1 CTH CTNS GCLM CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 ATP1A4 ATP1A3 CLCNKA SLC3A1 SLC3A2 ATP1A2 ATP1A1 SLC6A20 NR3C2 SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 ATP1B4 ATP1B3 ATP1B2 ATP1B1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SCNN1D SLC7A8 SLC7A9 SCNN1B FXYD2 SCNN1A FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD1L MTHFD2 FPGS MTHFR GGH MTHFS FTCD DHFR ALDH1L1 MTFMT SLC46A1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary ALDOA GFUS PHPT1 FBP1 PFKFB1 TPI1 PMM1 MPI SORD AKR1B1 HK1 KHK GMPPB PFKL GMDS FCSK FPGT ALDOB TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor GNAQ ITPR1 PRKCA PLCB1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase aceF mtlA pykF fbaB pgi fbaA pgk fbp yggF gpmI pfkA pfkB ybhA ppsA gapA glpX tpiA crr eno pykA mtlD ptsG ptsH gpmA GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid fbp yggF gpmI ybhA ppsA gapA glpX pckA dctA tpiA dcuB maeB dcuC maeA dcuA eno fbaB pgi fbaA pgk GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation kbaZ dgoT ptsH gatY gatZ dgoK gatA dgoD gatB pfkB gatC gatD dgoA kbaY GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis At4g37840 CTIMC MSSP1 PKP4 FBA1 GAPB FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism tpiA eno fruA fruB pykA gpmA ptsI pykF fbaB fruK fbaA pgk gpmI ppsA gapA GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) tpiA ugpQ glpA glpB glpC glpF pykA ptsG ptsH fbaB pgi fbaA pgk gpmI pfkA pfkB ybhA ppsA gapA crr eno gpsA gpmA glpK pykF fbp yggF glpQ glpT glpX THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH GLS2 gdhA DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer PC SLC7A7 SUCLG2 SUCLG1 ACO2 DLD alaC FH MYCBP GLS2 alaA DLST SLC1A4 PDHB SLC1A5 DHTKD1 LDHA MPC1 IDH3B ME1 DLAT SLC38A5 IDH3A PDHA1 SLC16A1 IDH3G GOT2 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 ACLY GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I CDC19 PGI1 TDH1 GPM2 EMI2 YOR283W TPI1 MAL11 YNR071C PFK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway DMGDH SLC44A1 SHMT2 SLC44A2 SHMT1 MTR MAT2B GNMT BHMT MAT2A CHDH SARDH ALDH7A1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism PGI1 SOR1 FBP26 PFK26 EMI2 PFK27 HXK1 HXK2 SUC2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PDC6 TPI1 PDC5 MAL11 PDC1 YNR071C ADH7 ADH6 GPM2 EMI2 YOR283W PFK1 CDC19 PGI1 TDH1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH GLS2 DLST PDHB DHTKD1 MPC1 IDH3B D2HGDH DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS GLUD1 PC SUCLG2 ACO1 SUCLG1 ACO2 L2HGDH DLD STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism ATH1 TSL1 GSY2 GSY1 GLK1 NTH1 EMI2 GLC3 NTH2 SUC2 PGI1 SPR1 GSC2 TPS3 NGK1 TPS2 EXG1 TPS1 EXG2 PRM15 FKS1 FKS3 YHL012W HXK1 BGL2 HXK2 ROT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism ARG82 INM1 INP51 IPK1 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism INM1 VPS15 INP51 PLC1 INP52 VAC14 VPS30 FAB1 PIK1 VPS34 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid MDH1 CTIMC NAD-ME1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis CYP98A3 F3H CYP73A5 DFRA CHS BAN CHI1 LDOX CCOAOMT1 CYP75B1 HST PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis ALB3 PSB27-1 PSAH2 PSAE1 PSB28 PSBO1 CFBP1 ATPC1 petC petD PSBS PSBR petA PSBW At1g32060 GAPA1 psbT PPD1 RBCS-1A PSAK psaD1 PSAL rbcL PSAG PSAF PSBP1 psbC YMF19 psbD PSBQ1 psbE psbF PSAO PSAN psbA psbB psbK PGK1 psbL psbM TKL-1 At3g55800 psbH psbI psbJ RPI1 atpI atpE atpH atpB atpA FBA1 At1g63290 psaB psaC psaA psaJ TIM ATPD LFNR1 DRT112 psaI CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle GAPA1 RBCS-1A PGK1 TIM TKL-1 rbcL At3g55800 FBA1 At1g63290 CFBP1 RPI1 At1g32060 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CYFBP CTIMC PFK1 PFP-ALPHA1 PFP-BETA1 At2g31390 FBA4 XYLA At1g48430 FKFBP HXK1 SDH PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT1A PCYT2 CHKA PEMT CEPT1 PISD DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 GPAM GPD1 LPIN1 AGPAT1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 PCYT2 CHKA CEPT1 PISD ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism DNAJB11 ERP29 HYOU1 PPIB PDIA2 SDF2L1 HSPA5 UGT1A1 SRD5A1 AKR1D1 HSD17B3 AKR1C4 CYP19A1 PDIA6 PDIA4 HSP90B1 HSD11B1 CYP11B1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 SDF2L1 HSPA5 UGT1A1 COMT CYP3A5 PDIA6 PDIA4 HSP90B1 SULT1E1 HSD17B1 DNAJB11 CYP1A1 ERP29 HYOU1 PPIB BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL MYC BCR-ABL1 MDM2 GRB2 JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A ABCB1 CDKN1B BAD SLC22A1 PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL JAK2 SOS1 SKP2 TP53 CRK BCL2L1 STAT5A CDKN1B BAD PIK3R1 GAB2 CBL MTOR CRKL RPS6KB1 MYC BCR-ABL1 MDM2 GRB2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B CHRM3 ATP4A CA1 CCKBR HRH2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3cd Inppl1 Zfyve16 Pik3r4 Prex1 Vac14 Inpp5f Ptpmt1 Plce1 Pik3c3 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Prex1 Ipmk Inppl1 Nudt10 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Ugt8 Gusb Hk1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 LPAR1 AKT1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ADCY1 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 AKT1 LPAR2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 GNAS AKT1 LPAR3 ADCY1 PLCB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling AKT1 ADCY1 LPAR4 PLCB1 GNG2 ROCK1 SRF GNB1 ITPR1 GNAS LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNAS AKT1 ADCY1 PLCB1 GNG2 ROCK1 LPAR5 SRF GNB1 ITPR1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 LPAR6 SRF GNB1 GNAS AKT1 ADCY1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKAR2B PRKAR2A PRKACG GNB1 GNAS PRKACA PRKACB GNGT1 ADCY10 PRKAR1B PRKAR1A AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis GZMB HMGB1 TOP2A DFFA CASP7 ENDOG CASP3 CAD HMGB2 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation PRMT1 NGF FGF1 TP53 RB1 BTG2 HOXB9 BTG1 CHAF1A CCND1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway DLG4 ITPR1 PRKCA NOS1 CALM1 PRKACB XDH GRIN1 PPP3CA GRIN2A GRIN3A ALDH2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium TRPC7 GUCY1A2 GUCY1B2 GUCY1A1 GUCY1B1 TRPC3 NOS3 TRPC4 ADCY10 TRPV4 KCNQ2 KCNQ3 KCNQ4 PRKG2 KCNQ5 PRKG1 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 CDKN1A PCNA APAF1 GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 CDK1 BCL2 E2F1 BAX PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PRKCA PLCG1 PLCB1 VAV1 PIK3CG PIK3R6 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway BAD FOXO4 PLD1 ELK1 RHOA CASP9 CDC42 PIK3CA AKT1 CYCS RAC1 RAF1 HRAS RALGDS MAPK3 BCL2L1 VAV3 RALA MAP2K1 SMAD4 RALBP1 SMAD3 APAF1 CHUK TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAPK14 TNF TANK NFKB1 IKBKB NFKBIA MAPK8 CASP2 RIPK1 IKBKG MAP2K7 MAP2K6 ATF1 MAP2K3 MAP2K4 MAP4K2 JUN MAP3K1 CHUK CRADD TRADD TRAF2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway MYLK CCND3 PAK1 RPS6KB1 CCND1 CDK5 MYL2 CFL1 ARFIP2 RAC1 PPP1R12B WASF1 CAP1 VAV3 PDGFRA CDKN1A RALBP1 PCNA MAP3K1 LIMK1 PLD1 ACTB CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages MAP2K1 PRKCB ITPR1 PRKCA CACNA1D CACNA1C CACNA1F NFKB1 RELA NFKBIA MAPK1 CACNA1S RAF1 PLCB1 HRAS MAPK3 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway GH1 SOCS1 RPS6KA1 MAPK1 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 HRAS MAPK3 STAT5A STAT5B MAP2K1 SHC1 IRS1 INSR PRKCA SLC2A4 INS GHR EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway SHC1 SRF ELK1 EGFR MAPK8 STAT6 PLCG1 HRAS JAK1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 CSNK2A1 EGF PRKCB STAT1 STAT2 STAT3 PRKCA FOS RASA1 GRB2 RAF1 SOS1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway CACNA1S MAP2K7 CGA PRKACA HRAS MAP2K3 MAP3K2 EGR1 JUN MAP2K1 MAP3K1 PRKCB FSHB MMP2 PLA2G4B CACNA2D2 PRKCA ACTN4 MAPK14 CACNB1 MMP14 LRRC7 GNAS GNRH1 GRB2 RAF1 SOS1 PLCB1 ATF4 HBEGF SRC CALML6 LHB CAMK2A ITPR1 CACNA1D ADCY1 CACNA1C CACNA1F PLD1 ELK1 EGFR CDC42 MAPK8 GNA11 GNRHR MAPK1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRADD TNF RELA CAMKK1 CAMKK2 IKBKB IRAK1 UBC RIPK1 FADD IKBKG MAP3K7 MAP3K1 CHUK IL1R1 NCOA3 TNFRSF1B NFKB1 TNFRSF1A NFKBIA IL1A TRAF6 TAB1 TLR4 MAP3K14 MYD88 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C7 C9 SERPING1 MASP2 MASP1 CFB C1QC MBL2 CFD C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C8A CFB CFD C3 C5 C6 C7 C9 CFP UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMD4 PSMB3 UBD UBC PSMB1 UBE2E1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMC3 PSMA1 PSMA2 PSMC4 PSMC1 PSMC2 UBA1 STUB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C7 C9 MASP2 MASP1 C4B_2 C8A C2 MBL2 C3 C4A C5 C6 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MYD88 TLR2 LY96 ECSIT ELK1 RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K6 MAP2K3 MAP2K4 JUN MAP3K1 CHUK EIF2AK2 FOS MAPK14 NFKB1 TIRAP NFKBIA TOLLIP TRAF6 TLR9 TAB2 TLR7 TAB1 PPARA TLR4 TLR3 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C1QB C1QA C1S C1R C4B_2 C8A C2 C3 C4A C5 C6 C7 C9 C1QC CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway MAPK1 PTK2B PLCG1 RAF1 HRAS CRK BCAR1 MAPK3 MAP2K1 PXN CXCR4 PIK3C2G NFKB1 GNAI1 PTK2 NFKBIA GNGT1 CXCL12 GNAQ GNB1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway JUN APAF1 PARP1 PRF1 GZMB ARHGAP5 CASP9 ARHGAP32 CASP8 CASP10 CASP3 ARHGDIB CASP1 CYCS T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway PLCG1 RAC1 HRAS MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFKB1 NFATC4 NFKBIA ZAP70 PIK3CA LCK CALM3 GRB2 CD247 PTPN7 RAF1 CALM1 SOS1 CALM2 LAT SHC1 TRAC CD3G PIK3R1 CD3E RASGRP1 CD3D ELK1 PIK3CG RELA PPP3CA PPP3CB MAPK8 PPP3CC TRBC1 UBC FYN STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway STAT3 MAPK1 TYK2 MTOR JAK1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 LY96 ECSIT RELA IKBKB MAPK8 IRAK1 CD14 IKBKG MAP3K7 MAP2K4 MAP3K1 CHUK MAPK14 NFKB1 TIRAP fliC NFKBIA TLR1 TOLLIP TRAF6 TLR9 TAB3 TLR8 TAB2 TLR7 TAB1 TLR6 TLR5 TLR4 TLR3 MYD88 TLR2 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway HRAS MAPK3 STAT5A JUN MAP2K1 EPO SHC1 FOS ELK1 EPOR MAPK8 PTPN6 GRB2 PLCG1 JAK2 RAF1 SOS1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 CASP7 PAK1 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD MAP3K7 PAK2 SPTAN1 DFFB MAP2K4 DFFA JUN DAXX MAP3K1 PARP1 RIPK2 CFLAR PTPN13 FAS BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway RAF1 CALM1 SOS1 CALM2 SHC1 ELK1 CD79B CD79A PPP3CA PPP3CB MAPK8 PPP3CC BLNK PLCG1 RAC1 HRAS MAPK3 LYN JUN MAP2K1 MAP3K1 SYK PRKCB NFATC3 NFATC2 NFATC1 PRKCA FOS VAV1 NFATC4 BTK ORAI1 CALM3 GRB2 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PGS1 AGPAT5 GPAM PTPMT1 GPD1 CRLS1 CDS2 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling IL1B P4HA3 NLRP3 TLR4 HIF1A SIRT3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 TP53 SIRT1 NADK NQO1 NMNAT1 AIFM2 NAMPT CD38 NMNAT3 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT3 NMNAT2 CLOCK SIRT1 PPARGC1A NADK NQO1 NMNAT1 NPR1 NAMPT RORA SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation SUCNR1 CHUK NOS3 PRKCA NFKB1 PTGS1 IKBKB MAPK11 CREB1 MAPK1 IKBKG PLCB1 MAPK3 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLC10A2 SLCO1A2 NR1H4 GPBAR1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 SLC10A2 NR1H4 FGFR4 FGFR3 FGFR2 FGFR1 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Slc2a13 Fh Mdh1 Slc16a1 Idh1 Cad Gsr Idh3a Pgd Hk1 Bckdhb Pkm Ireb2 Aco1 Pdhx Gpi H6pd Glud1 Taldo1 Eno1 Gapdhs Sdhd Aldoc Bpgm Sdhc Sdhb Sdha Gls Rpia Acly Tktl1 Cs Idh3g Mpc1 Ogdh Pgk2 Pfkm Sucla2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation PHPT1 FBP1 PFKFB1 TPI1 TGDS MPI PMM2 SORD AKR1B1 KHK HK1 GMPPB PFKL FCSK FPGT ALDOB GFUS GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis GPI TPI1 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PKM GALM ALDOB PFKM GAPDH GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis MPC1 GALM ALDOB PCK1 FBP1 GAPDH SLC25A11 PGM1 GPI PANK3 TPI1 MDH2 PGAM1 PGAM2 SLC2A2 ENO1 BPGM G6PC1 HK1 PC INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism AMBRA1 INPP4A MINPP1 SYNJ1 PIK3CA IMPA1 PTPMT1 ITPKA PI4KA PLCD1 IPPK CCT3 VAC14 MIOX BECN1 ISYNA1 INPP1 SACM1L IPMK ITPK1 PIK3R4 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway PRPS1 GPI G6PD RPE TALDO1 DERA RPIA PFKL PGLS ALDOB TKT FBP1 RBKS PGM1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism GPI AGL GAA PYGL PGM2L1 HK1 GYS1 UGDH UGP2 LOC539383 UGT3A1 GUSB PGM1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism IPPK ISYNA1 INPP1 IPMK ITPK1 NUDT3 INPP4A INPP4B MINPP1 PPIP5K1 SYNJ1 IMPA1 ITPKA IP6K1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect PGAM2 TALDO1 SDHC SDHD PGD SDHA SDHB CS RPIA GLUD1 PFKL PKM PC OGDH SUCLG2 ACO1 SUCLG1 ACO2 ALDOB TKT DLD GAPDH GPI FH GLS2 SLC2A2 DLST SLC1A5 ENO1 PDHB HK1 MPC1 IDH3B PGK1 PGLS IDH3A PDHX G6PD PDHA1 SLC16A1 MDH1 IDH3G IDH1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Isyna1 Vac14 Becn1 Sacm1l Ambra1 Minpp1 Pik3r4 Itpka Ippk Cct3 Miox Ptpmt1 Inpp4a Ipmk Impa1 Bpnt1 Pik3c3 Plcd1 Inpp5j PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpka Ippk Inpp4a Inpp4b Ipmk Impa1 Bpnt1 Ip6k1 Inpp5j Itpk1 Isyna1 Ppip5k1 Nudt3 Minpp1 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg2 Pgam2 Slc2a2 Pgk1 Slc1a3 Fh Mdh1 Slc16a1 Idh1 Idh3a Dlst Pdhb Pgd Gapdh Hk2 Pkm Aco2 Pgls Dlat Aco1 Tkt Dld Gpi Pklr Glud1 Taldo1 Aldob Eno1 Sdhd Sdhc Sdhb Sdha Gls Idh3B Rpia Cs Dhtkd1 Pdha1 Pfkl Idh3g Suclg1 Mpc1 G6pdx NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Uxs Gale Galt Hex-T Galk sgl Pgm1 Ugp GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Galm2 Pyk Hex-T Gapdh1 Eno Aldo Tpi Pgi Pfk Glut1 CG15400 Pgam2 Pgam1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism INPP5E mTor CG1846 Dmel\CG9391 IP3K2 Mipp1 Sac1 Atg6 norpA Miox fab1 Pi4KIIIalpha Ipp Pi3K92E Inos Ipk2 Vps15 Ipk1 Dmel\CG5608 PTPMT1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway G6pd Prps Rpe Taldo Aldo Rpi Dmel\CG13369 Dera Pgi Pfk Fbp Pgls Tkt Pgm1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism CG1846 Dmel\CG9391 IP3K2 Inos Mipp1 Ipk2 Ip6k Ipk1 Aps l(1)G0196 INPP5E Ipp WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Idh3a ScsbetaG Dlst SdhD Pdhb SdhC SdhB Pgd SdhA Pcb Fum1 Pgi Pgk Pgls Dlat Tkt Irp-1A Dld Gapdh1 Eno Taldo Aldo Rpi Gdh Scsalpha1 Idh Gls Pdha1 Oadh Pfk Mpc1 Glut1 Mct1 Pgam2 Eaat1 Cs1 G6pd Pyk Hex-T Mdh1 mAcon2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis pfk-1.1 gpd-3 hxk-1 fdgt-1 enol-1 pyk-1 C01B4.6 tpi-1 gpi-1 aldo-1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ttx-7 cct-3 inos-1 ipmk-1 vps-15 age-1 unc-26 gpap-1 CELE_F28C6.8 egl-8 ippk-1 vps-34 bec-1 lfe-2 vacl-14 C54E4.5 inpp-4b SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism spl-1 C29E4.10 gana-1 sphk-1 sul-2 sptl-1 F53B1.2 plpp-1.2 bre-4 dhs-3 W02F12.2 sptl-2 ugt-58 cerk-1 ttm-5 enpp-1 gba-3 cgt-3 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway pgm-1 CELE_F08F8.7 F09E5.3 gspd-1 Y57G11C.3 prps-1 tald-1 fbp-1 tkt-1 rpia-1 CELE_F07A11.5 gpi-1 aldo-1 pfk-1.1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism gpap-1 inpp-4b ttx-7 CELE_Y92H12BL.5 F46F11.1 ippk-1 lfe-2 inos-1 ipmk-1 CELE_F30A10.3 unc-26 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect mev-1 Y57G11C.3 cts-1 mpc-1 enol-1 tald-1 dld-1 sucl-1 aco-1 fum-1 sucg-1 aco-2 mdh-1 pyc-1 aldo-1 T25B9.9 sdhb-1 pdha-1 sdha-1 pdhb-1 pyk-1 ogdh-2 gspd-1 glt-1 hxk-1 fdgt-1 tkt-1 glna-2 gdh-1 rpia-1 dlat-1 gpi-1 pfk-1.1 sdhd-1 gpd-3 pgk-1 idha-1 idh-1 idhb-1 mct-6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG TRAF3 TRAF6 IKBKG G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB GNGT1 CHRM1 GNAQ GNB1 HTR2C PLCB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ADAM17 ERBB3 ERBB4 PRKCA NRG2 PSEN1 EGFR ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCB P2RY2 PTK2B PRKCA PLCG1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 CSNK1E CLOCK HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TIRAP RELA ACACA IKBKB CS NFKBIA ACLY TRAF6 ME1 PFK1 CD14 IKBKG TLR4 MYD88 SLC25A1 CHUK MDH1 LY96 SDHC SDHD SDHA SDHB NFKB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine RPL26 RPL29 RPL28 UBA52 AARS1 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Prkca Plcb1 Itpr1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells IGHE Grb2 Prkca Raf1 Csf2 Pik3r1 Lat Hras Inpp5d Mapk8 Il13 Mapk1 Map2k7 Tnf Fcer1a Il4 Il5 Akt1 Kras Fyn Rac1 Pdk1 Lyn Mapk14 Syk Plcg1 Gab2 Ms4a2 Vav1 Rasgrf1 Map2k2 Nras Map2k1 Lck Fcer1g Blnk NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Ppp3ca Dlg4 Calm3 Nos1 Prkca Prkacb Grin1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Plcg1 Akt1 Pik3r6 Prkca Vav1 Plcb1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Prkca Raf1 Nfkbia Hras Rela Mapk3 Plcb1 Itpr1 Map2k1 Prkcb Mapk1 Nfkb1 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RARS1 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 NARS1 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 DARS1 RPL37A RPL24 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL26 RPL29 CARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 QARS1 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 GARS1 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 HARS1 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 IARS1 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 LARS1 RPL37A RPL24 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL26 RPL29 RPL28 UBA52 RPL10 KARS1 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 MARS1 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU FARSA RPS21 RPS24 RPS23 FARSB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 EPRS1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 SARS1 RPL37A RPL24 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL26 RPL29 TARS1 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A WARS1 RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL27 RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 YARS1 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine RPL26 RPL29 RPL28 UBA52 RPL10 RPL12 RPL11 RPL36A RPS15A RPS3 RPL14 RPL13 RPS2 RPL15 RPL18 RPL17 VARS1 RPL19 RPL41 RPL35A RPL23A RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPS14 RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RACK1 RPL36 RPLP2 RPL35 RPL38 RPL37 RPS11 RPS10 RPL39 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rplp1 Rpl23 Rpl13a Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps4x Rps26 Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl5 Rps15 Rps16 Rpl3 Rps17 Rps15a Rps18 Rps19 Rpl35 Rpl36 Rpsa Rpl37 Rpl38 Rpl39 Rpl8 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Aars1 Rpl30 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a Rps9 Rps7 Rps8 Rpl37a Rps5 Rps6 Rplp2 Rpl24 Rpl26 Uba52 Rpl27 Rack1 Rpl28 Rpl29 Rpl21 Rplp0 Rpl22 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Gpi H6pd Rpe Prpsap1 Taldo1 Aldob Pgd Rpia Dera Tktl1 Pfkm Rbks Fbp2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Ugt8 Gusb Hk1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Ugt8 Gusb Hk1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Ugt8 Gusb Hk1 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Ugt8 Gusb Hk1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Slc2a13 Gpi Tpi1 Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pkm Pgam1 Galm Pgk2 Pfkp GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Pgam1 Galm Pck2 Fbp2 Slc2a13 Gpi Tpi1 Mdh2 Cad Eno1 Gapdhs Aldob Bpgm Hk1 G6pc3 Pank4 Mpc1 Slc25a18 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Tpi1 Aldob Aldoc Pfkm Hk1 Fbp2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Gpi Taldo1 Aldoa Rpia Dera Prps1 Pfkl G6pdx Pgls Tkt Fbp1 Rbks Pgm1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Pgm2l1 Gpi Agl Pygl Gck Hk2 Ugt2b1 Gys2 Si Amy2 Ugp2 Ugdh Pgm1 Gusb PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Gpi Tpi1 Pklr Eno1 Gapdh G6pc1 Aldoa Hk2 Pgam2 Slc2a2 Pgam1 Galm Pfkm GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Galm Pck1 Fbp1 Pgm1 Gpi Tpi1 Mdh2 Eno1 Gapdh G6pc1 Aldoa Hk2 Pank4 Mpc1 Pgam2 Slc25a11 Slc2a2 Pgam1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Fbp1 Gmppa Tpi1 Pmm1 Mpi Sord Uxs1 Aldob Aldoa Hk1 Khk Pfkl Pfkfb1 Fcsk Gmds Akr1b1 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Ikbkg Prkca Ptgs1 Mapk3 Plcb1 Creb1 Ikbkb Mapk14 Nos3 Mapk1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Ghr Gh1 Stat5a Stat5b Map2k1 Rps6ka1 Slc2a4 Grb2 Prkca Raf1 Jak2 Hras Socs1 Shc1 Irs1 Ins2 Insr Plcg1 Mapk1 Ptpn6 Mapk3 Rasgrf1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Fos Csnk2a1 Elk1 Map2k7 Mapk3 Rasgrf1 Stat5a Map3k1 Map2k1 Prkcb Stat3 Grb2 Prkca Raf1 Jak2 Hras Jun Mapk8 Shc1 Rasa1 Egf Srf Erbb4 Plcg1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Prkaca Rasgrf1 Map3k1 Map2k1 Prkcb Grb2 Actn4 Prkca Raf1 Hras Atf4 Itpr1 Gna11 Mapk8 Src Fshb Erbb4 Lhb Gnrh1 Mapk1 Calm3 Gnrhr Pla2g4a Elk1 Pld1 Map2k7 Hbegf Plcb1 Camk2a Cga Adcy5 Cdc42 Egr1 Jun Mapk14 Mmp14 Lrrc7 Mmp2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Nfat5 Map3k1 Map2k1 Prkcb Lck Rasgrp1 Grb2 Prkca Raf1 Pik3r1 Lat Hras Mapk8 Shc1 Ptpn7 Calm3 Cd247 Cd3g Elk1 Cd3e Cd3d Map2k7 Mapk3 Ubc Nfkb1 Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Plcg1 Fos Nfkbia Vav1 Rela Rasgrf1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Cd79a Cd79b Mapk8 Shc1 Calm3 Elk1 Mapk3 Rac1 Lyn Ppp3ca Jun Ppp3cb Syk Plcg1 Orai1 Fos Vav1 Rasgrf1 Nfat5 Map3k1 Map2k1 Prkcb Lck Blnk Grb2 Prkca Raf1 Hras G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC4A4 SLC9A1 AQP1 SLC7A5 CA1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC38A4 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle SLC12A1 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 FXYD2 REN SLC12A6 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SCNN1G CA1 SCNN1D SCNN1B FXYD2 SCNN1A REN ATP6V1B1 SLC14A2 ATP1A4 ATP1B4 ATP1A3 SLC4A1 ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP4A FXYD2 TRPV5 REN SLC12A3 ATP1A4 ATP1B4 ATP1A3 CLCNKA ATP1A2 ATP1B3 ATP1A1 ATP1B2 ATP1B1 AQP2 AQP3 SLC8A1 ATP4B PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GNG2 GNAQ GNB1 PLCB1 VAMP2 RAPGEF4 GLP1R CHRM3 RAB3A ABCC8 CACNA1A SLC2A2 CACNA2D2 PRKCA ITPR3 CAMKK1 CACNB1 RIMS2 ADCY10 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SCN5A SNTB1 SNTA1 SNTB2 CACNB1 ABCC8 CACNA1A SLC2A2 CACNA2D2 GCG MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway PMVK MVD HMGCR LSS ACAT1 FDFT1 FDPS IDI1 SQLE MVK HMGCS1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) HSD17B7 LBR EBP NSDHL CYP51A1 SC5D DHCR24 MSMO1 DHCR7 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification AS3MT PNP GSTO1 AQP9 SLC2A1 AQP7 SLC2A4 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis GNG2 CYP11A1 CYP21A2 CYP11B2 GNAQ HSD3B1 GNB1 AGTR1 PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell CACNB1 SST ABCC8 CACNA1A SLC2A2 CACNA2D2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation DLST ALDH8A1 DLD ACMSD DHTKD1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism tpiA pgk eno ppsA GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) tpiA pgi pgk fbp eno ppsA GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) tpiA pgi pgk fbp eno ppsA SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%74752 Signaling by Insulin receptor ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 FGF20 THEM4 ATP6V1H MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 MAPK3 PTPN1 INSR PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 KLB FLT3 IRS1 PDE3B IRS2 PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 PTPRF FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 TRIB3 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5688399 Defective ABCA3 causes SMDP3 ABCA3 LONG-TERM POTENTIATION%REACTOME%R-HSA-9620244.3 Long-term potentiation GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2C GRIN2B NRGN GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC15 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 95%5693579 Homologous DNA Pairing and Strand Exchange BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 95%9842640 Signaling by LTK in cancer MAPK1 PIK3CB PIK3R2 PIK3R1 PIK3CA MAPK3 CLIP1 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC SLC25A15 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 DEFB130A BPI PRTN3 DEFB130B S100A9 DEFB4B S100A8 LTF TLR2 S100A7 DEFB103B REG3A DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%75105 Fatty acyl-CoA biosynthesis SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 95%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation PLK1 TCF7L2 CCNB1 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B TBX2 HINT1 CCND1 SIN3A CDK2 CTNNB1 MET RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9648895 Response of EIF2AK1 (HRI) to heme deficiency CHAC1 ATF5 ATF3 ATF4 GRB10 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9764562 Regulation of CDH1 mRNA translation by microRNAs TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements YWHAB HSPB1 ELAVL1 PSMD8 PSMD6 ZFP36 PSMD7 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.4 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 CCNB2 NEK9 CCNB1 NEK6 NEK7 CDK1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 95%111463 SMAC (DIABLO) binds to IAPs XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 95%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3 GZMM CFB EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-HSA-9036866.4 Expression and Processing of Neurotrophins FURIN PCSK6 NGF PCSK5 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.4 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.4 RHOBTB1 GTPase cycle HNRNPC CCT7 RBMX DBN1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 95%3134975 Regulation of innate immune responses to cytosolic DNA UBC ZBP1 TREX1 RPS27A DDX41 DTX4 TBK1 IRF3 STING1 NLRP4 UBA52 TRIM32 TRIM21 TRIM56 UBB CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation CSPG4 GUSB ARSB IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 95%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME%R-HSA-5637815.3 Signaling by Ligand-Responsive EGFR Variants in Cancer SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 DAXX ATRX CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 95%9616222 Transcriptional regulation of granulopoiesis RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 CDKN1A DEK FLI1 KLF5 H2AC20 LEF1 CDK2 CEBPB MYC E2F1 TFDP1 TFDP2 CDK4 H2AX CSF3R SPI1 GFI1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TAL1 H2BC11 RARA CEBPA KMT2A CBFB CEBPE GATA2 H3C15 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%9024446 LXR-mediated signaling RXRA SCD FASN CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 FABP6 EP300 APOC2 APOC1 AGO1 ANGPTL3 AGO2 PLIN1 TNRC6A ABCG1 TNRC6B BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 95%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein SRD5A3 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 95%9937383 Mitochondrial ribosome-associated quality control MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MRPS17 MRPS15 MRPS16 MRPS14 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8931838 DAG1 glycosylations CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 95%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 95%193648 NRAGE signals death through JNK TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 VITAMINS%REACTOME%R-HSA-211916.3 Vitamins CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 TFAP2A TFAP2B WWOX TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 95%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 95%111459 Activation of caspases through apoptosome-mediated cleavage XIAP CYCS CASP9 CASP7 APAF1 CASP3 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 CCNE1 STAT3 HDAC3 GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 95%5663220 RHO GTPases Activate Formins NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 RAC1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 ACTB CLIP1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.3 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964539 Glutamate and glutamine metabolism OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS GLUD1 GLUD2 KYAT1 RIMKLA GLUL RIMKLB PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 95%5654227 Phospholipase C-mediated cascade; FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 PLCG1 FGF20 FGF16 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) DAXX ATRX INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 95%167169 HIV Transcription Elongation CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9831926 Nephron development DLL1 POU3F3 WNT4 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 95%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.6 Switching of origins to a post-replicative state ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-HSA-9034013.2 NTF3 activates NTRK3 signaling NTRK3 NTF3 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides SLC15A1 CTNS SLC15A3 SLC15A4 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 95%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 YWHAB RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB RAPGEF3 SIPA1 RAPGEF4 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1475029 Reversible hydration of carbon dioxide CA4 CA7 CA6 CA9 CA14 CA13 CA12 CA1 CA3 CA5B CA2 CA5A SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 DICER1 TARBP2 TSN AGO1 AGO2 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels TRPC4AP TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPA1 TRPC3 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 MCOLN1 MCOLN2 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 95%390648 Muscarinic acetylcholine receptors CHRM2 CHRM3 CHRM1 CHRM4 CHRM5 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9735869 SARS-CoV-1 modulates host translation machinery RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 95%5083630 Defective LFNG causes SCDO3 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB LRRK2 PTK6 HBEGF EGFR HIF1A DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 95%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME%R-HSA-9956514.1 ARG1 variants cause hyperargininemia ARG1 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle CCT6A HSP90AA1 CDC37 HSP90AB1 RNF20 TWF1 SPEN MSI2 CCT2 RHOBTB2 CPSF7 ROCK1 ACTN1 ROCK2 TMOD3 GPS1 DDX39B CUL3 PHIP TXNL1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 ACTG1 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM7 MCM8 GINS1 GINS2 CDC45 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 MCM2 MTOR SIGNALLING%REACTOME%R-HSA-165159.8 MTOR signalling PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA AKT2 STRADB TSC2 TSC1 PRKAB1 YWHAB RPS6 MTOR FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 AKT1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.2 RAC3 GTPase cycle TIAM1 ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 PIK3R2 NOXA1 PIK3R1 ABI1 NOX3 ESYT1 FERMT2 NOX1 ABR MCF2 CDC42 LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SRGAP2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 DIAPH3 ITGB1 GIT2 VAV2 CAV1 MCAM LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR2 TGFB1 TGFBR1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 95%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 95%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 HMGA1 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 TP53 H1-5 H1-4 HIRA UBN1 EP400 ASF1A INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 95%9014826 Interleukin-36 pathway IL36B IL36G IL36RN IL1F10 IL1RL2 IL36A DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%376172 DSCAM interactions DSCAM DCC DSCAML1 NTN1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 95%167158 Formation of the HIV-1 Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 95%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013148 CDC42 GTPase cycle ARHGAP26 BAIAP2 VANGL1 ARHGAP32 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 DAAM1 CDC42EP3 TRIO CDC42EP2 RASGRF2 WAS ITSN1 PARD6A PLEKHG4B CHN1 PAK6 PREX1 STOM MCF2L PAK3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 CDC42BPB SRGAP2 ARHGEF10 CDC42BPA ARHGEF12 DEF6 PLEKHG2 KTN1 ARHGEF15 SHKBP1 DLC1 ARHGEF16 ARHGEF19 DIAPH3 VAV2 TIAM1 ARHGEF9 ARHGEF4 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF ARHGEF6 ARHGEF26 FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 MCF2 CDC42 FMNL3 FMNL1 FMNL2 LAMTOR1 TFRC SNAP23 ARHGAP1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 SYDE1 ARHGAP42 OPHN1 ARHGDIB LBR GIT1 TMPO ARAP2 ARAP3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A ARHGAP17 ARHGAP21 PAK1 RACGAP1 PAK2 YKT6 PAK4 GIT2 CAV1 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 95%445144 Signal transduction by L1 NCAM1 ITGA5 ITGA9 EGFR CSNK2A1 CSNK2A2 PAK1 MAPK1 RAC1 CSNK2B NRP1 MAP2K1 MAP2K2 MAPK3 ITGB3 ITGB1 ITGA2B L1CAM VAV2 ITGAV MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%5657655 MGMT-mediated DNA damage reversal MGMT MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBC RPS27A UBA52 UBB ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 95%3000178 ECM proteoglycans NCAM1 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TGFB1 TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 TNXB LRP4 ACAN TGFB2 LUM TGFB3 DSPP COL9A1 COL9A3 COL9A2 AGRN FMOD NCAN BGN DCN BCAN VCAN LAMA5 LAMA2 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC1 VTN DAG1 ITGB3 ITGB1 ITGA2B ITGAV SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4551638 SUMOylation of chromatin organization proteins H4C9 HDAC1 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I HDAC4 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 NUP205 CBX5 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 95%4839744 Signaling by APC mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E GLYCOLYSIS%REACTOME DATABASE ID RELEASE 95%70171 Glycolysis GCKR GCK PPP2R5D PRKACG PRKACA PRKACB PPP2CA PPP2CB HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 NUP37 PGK2 PFKL GNPDA1 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME%R-HSA-3065678.4 SUMO is transferred from E1 to E2 (UBE2I, UBC9) SAE1 SUMO3 SUMO2 UBE2I SUMO1 RWDD3 UBA2 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes CREBBP SP1 BCL2 PDGFA MAFK AREG EGF NFE2L2 BCL2L1 EP300 NOTCH1 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA BTLA PTPN6 TNFRSF14 PTPN11 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 95%380095 Tachykinin receptors bind tachykinins TAC1 TACR2 TACR3 TAC3 TACR1 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 95%9005891 Loss of function of MECP2 in Rett syndrome CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9028335 Activated NTRK2 signals through PI3K NTF4 NTRK2 BDNF GAB1 PIK3R1 PIK3CA ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964540 Alanine metabolism GPT ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 95%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling BCL2 HBEGF AREG EGF EGFR AKT2 CDKN1B MAPK1 CCND1 TGFA XPO1 FOS FOXO3 ELK1 SRF PTK2 AKT1 EREG MAPK3 UHMK1 BTC EPGN AKT3 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME DATABASE ID RELEASE 95%9673324 WNT5:FZD7-mediated leishmania damping JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels KCNJ8 KCNJ11 ABCC8 ABCC9 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME DATABASE ID RELEASE 95%170660 Adenylate cyclase activating pathway ADCY5 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.4 Platelet homeostasis GNG13 GNB2 PPP2R5B GNB1 PPP2R5A PPP2R5D PPP2R5C GNB4 GNB3 GNB5 GNGT1 GUCY1B2 GNGT2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PDE5A PLA2G4A PTPN11 FGR STIM1 KCNMA1 PPP2CA ORAI2 PPP2CB PECAM1 ORAI1 PDE9A PDE1B GNG3 PDE1A ITPR1 ITPR2 GNG2 ITPR3 GNG5 SRI GNG4 LRP8 GNG7 PDE11A KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 APOB TRPC7 NOS2 NOS3 PDE2A TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 PDE10A P2RX3 P2RX2 P2RX1 GNAS PPP2R1B PPP2R1A PTPN6 MAPK14 GNG10 GNG12 PPP2R5E GNG11 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME%R-HSA-6782861.3 Synthesis of wybutosine at G37 of tRNA(Phe) TYW5 TYW3 TRMT5 TYW2 TYW1 LCMT2 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 95%8964572 Lipid particle organization CIDEC HILPDA CIDEA FITM1 HSD17B13 FITM2 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF2S2 EIF2S1 EIF2S3 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation UBC RPS27A RAB7A KPNA1 UBA52 ATP6V1H NOS2 VPS33B CORO1A HGS RAB5A KPNB1 UBB VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.4 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity UBC MAFK SKP2 RPS27A SKP1 RBX1 UBA52 FBXL17 BACH1 UBB CUL1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%169911 Regulation of Apoptosis OMA1 OPA1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ARHGAP10 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPK1 MAPK3 PPP2R1B PPP2R1A MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB ST6GALNAC3 MAN2A1 MGAT5 ST6GALNAC4 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC ST3GAL4 MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 ST6GAL1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%391908 Prostanoid ligand receptors PTGDR PTGER4 PTGFR PTGER1 PTGIR TBXA2R PTGDR2 PTGER2 PTGER3 DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 95%5688426 Deubiquitination HGS MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 TRIM25 NFRKB PSMD1 USP17L30 HIF1A YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 BRCC3 PSMA1 SNX3 RHOT1 PSMA2 RCE1 ZRANB1 UBA52 SIAH2 INO80 STAM PSMD12 TADA2B PSMD11 CYLD H2AC25 PSMD14 H2AC21 BAP1 PSMD13 WDR48 OTUD7A PSMA7 OTUD7B BABAM1 PSMB6 IFIH1 BABAM2 PSMB7 UCHL1 TRIM4 PSMB4 UIMC1 UFD1 PSMB5 ACTB IKBKG TOMM70 UBB RIPK2 PSMB2 ACTL6A PSMB3 JOSD2 UCHL3 UBC JOSD1 PSMB1 UCHL5 DDB2 RPS27A KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 RNF135 PSMC6 STAMBPL1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 MBD5 PSMC2 USP17L18 MBD6 USP17L17 TP53 USP9X USP17L19 MCRS1 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 IL33 USP3 USP2 MUL1 TGFB1 H2AC1 TGFBR1 CDC25A TGFBR2 FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 ABRAXAS1 SKP2 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B CDC20 NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 EP300 ASXL1 TNIP1 TNIP2 TNIP3 H2AC8 ASXL2 H2AC6 OTUD3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RHOA KDM1B AXIN1 APC UBE2D1 CDK1 BRCA1 BARD1 SEM1 CCNA2 CCNA1 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932505 DAG1 core M3 glycosylations POMK DAG1 POMT2 B3GALNT2 POMT1 POMGNT2 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism GAMT GATM SLC6A7 SLC6A8 CKM CKMT1B SLC6A11 CKB SLC6A12 CKMT2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 95%72203 Processing of Capped Intron-Containing Pre-mRNA SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B EIF4E NUP214 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 UBB UBC RPS27A HSPA8 XRN2 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35C1 PDZD11 SLC25A5 APOD SLC25A4 SLC25A6 SLC35B3 LCN9 SLC35B2 SLC27A1 SLC35B4 SLC35D1 SLC35D2 LCN15 LCN12 SLC35A2 SLC35A3 SLC33A1 SLC5A6 ARL2BP LCN1 SLC29A4 SLC27A6 SLC28A2 SLC35A1 SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC27A4 ARL2 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.4 Amine ligand-binding receptors HTR6 TAAR3P HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D CHRM2 HTR1A CHRM3 TAAR5 CHRM1 HTR1B CHRM4 TAAR2 CHRM5 ADRA2C HTR5A ADRA2B TAAR1 ADRA2A ADRB2 GPR143 ADRB3 HTR2B HTR2C ADRB1 ADRA1D HTR2A ADRA1B HTR4 ADRA1A HRH1 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ZNF568 ZNF567 ZNF566 ZNF324 ZNF565 ZFP37 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 INS MAPK1 MAPK3 PTPN1 PTPN11 SNW1 CAMK2B GRIA2 CAMK2D SRC CAMK2A GRIN2B GRIN2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51D RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A YBX1 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654700 FRS-mediated FGFR2 signaling FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 FGF16 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 95%9706374 FLT3 signaling through SRC family kinases LCK FYN FLT3LG FLT3 HCK SYK GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 95%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 F9 PROC F10 GGCX PROS1 FURIN PROZ F2 BGLAP GAS6 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency BCKDK BCKDHA BCKDHB DBT DLD LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG LDLRAP1 AP2M1 CUBN CETP AMN ZDHHC8 APOA2 APOA1 LSR APOA4 PRKACG APOA5 NPC1 PRKACA SOAT1 PRKACB SOAT2 NPC2 APOE ANGPTL8 ANGPTL4 LPA CES3 ABCA1 SAR1B MTTP MYLIP LPL LMF2 LMF1 NR1H2 APOF APOC4 AP2S1 NR1H3 A2M LDLR GPIHBP1 FGF21 MBTPS1 APOBR APOC3 APOC2 AP2B1 APOC1 ANGPTL3 NCEH1 ALB ABCG1 P4HB MBTPS2 APOB UBA52 UBB UBC RPS27A VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 95%196843 Vitamin B2 (riboflavin) metabolism RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 FLAD1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP1 MIP AQP11 AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 95%446353 Cell-extracellular matrix interactions VASP FBLIM1 PXN TESK1 ILK PARVA PARVB FLNA FLNC ARHGEF6 RSU1 FERMT2 LIMS2 LIMS1 ACTN1 ITGB1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610780 Degradation of GLI1 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 ITCH PSMD14 SUFU BTRC PSMD13 NUMB PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME%R-HSA-9845619.1 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME%R-HSA-5619041.4 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP ELAC2 TRNT1 HSD17B10 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 95%2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB ADCY1 ADCY8 CALM1 PRKAR1B PRKAR2B DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 95%4793952 Defective MGAT2 causes CDG-2a MGAT2 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway FZD2 GNG13 FZD5 WNT5A FZD4 GNB2 PDE6G FZD6 GNB1 NFATC1 GNAO1 MAP3K7 GNB4 TCF7L2 GNB3 TCF7L1 GNB5 LEF1 GNGT1 TCF7 GNGT2 CTNNB1 PRKG2 TNRC6C MOV10 GNG3 AGO3 ITPR1 AGO4 ITPR2 GNG2 ITPR3 GNG5 GNG4 AGO1 GNG7 AGO2 TNRC6A GNG8 TNRC6B CAMK2A CALM1 PRKCA PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 GNG10 NLK PPP3R1 WNT11 PDE6B PDE6A GNG12 FZD3 GNG11 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 95%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 95%72306 tRNA processing CPSF4 CPSF1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TYW5 NUP43 TYW3 RAE1 TRMT5 TYW2 NDC1 TYW1 RANBP2 SEC13 LCMT2 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TRMT10C PRORP ELAC2 TRNT1 HSD17B10 TP53RK CLP1 POP5 POP7 OSGEPL1 POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 RPP38 PUS3 METTL1 CSTF2 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU QNG1 TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 TSEN34 URM1 LAGE3 RPP14 TRDMT1 RTRAF TRMT10A ADAT1 NUP214 TPRKB TRMT1 ADAT3 TRIT1 ADAT2 XPOT TRMT6 FAM98B TRMT61A TRMT61B RAN DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 95%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670621 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 95%380270 Recruitment of mitotic centrosome proteins and complexes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME%R-HSA-9034864.2 Activated NTRK3 signals through RAS HRAS SOS1 NTRK3 NTF3 NRAS ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 ATP2A3 SLC9B2 RAF1 ATP2A2 SCNN1G ATP2A1 SCNN1D SCNN1B SCNN1A ATP7A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TRPM1 ATP4B SRI TRPM2 ATP4A TRPM7 FXYD4 TRPM8 FXYD3 TRPM5 WNK1 TRPM6 FXYD2 TRPM3 WNK2 TRPM4 FXYD1 WNK3 TRPC7 FXYD7 TRPC5 FXYD6 MCOLN3 CUTC TRPC6 ATP2B4 RYR1 TRPA1 ATP2B3 RYR2 TRPC3 ATP2B2 RYR3 TRPC4 ATP2B1 UNC80 TRPC1 TRPV2 ATP7B TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN PDZD11 ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 TCIRG1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 ATP6V1E1 STOM ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 ATP6V0D1 NEDD4L ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 SGK1 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 CAMK2B CAMK2D CAMK2A CALM1 CAMK2G UBA52 WWP1 UBB UBC RPS27A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBC RPS27A SMURF1 PARD6A CGN UBA52 F11R PRKCZ TGFB1 RHOA PARD3 TGFBR1 TGFBR2 FKBP1A ARHGEF18 UBB CELL DIVISION%REACTOME DATABASE ID RELEASE 95%68884 cell division PLK1 KIF23 PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 KIF20A ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 95%8847993 ERBB2 Activates PTK6 Signaling NRG1 PTK6 HBEGF EGF ERBB2 EGFR NRG3 EREG NRG4 BTC NRG2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110329 Cleavage of the damaged pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 95%5545483 Defective Mismatch Repair Associated With MLH1 MLH1 PMS2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism MOGAT3 MOGAT2 GPAM MOGAT1 PPP1CA ABHD5 FABP12 PRKACG GK3 GK2 PRKACA LIPE PRKACB AGMO GPAT2 DGAT2 GK DGAT1 PPP1CB FABP9 PPP1CC FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 FABP6 LPIN2 MGLL LPIN3 PLIN1 CAV1 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP CITED1 CITED2 YEATS4 CITED4 TFAP2A TFAP2B WWOX EP300 TFAP2C TFAP2D TFAP2E ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 GLUL SLC38A1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%212165 Epigenetic regulation of gene expression ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP GPAM ERCC6 ANGPTL4 LPL RBM7 DPY30 CHD4 TBP EED SAP18 MTA2 CIDEC MTA1 MTA3 MED1 MORC2 ACSL1 ELOVL5 MED4 MED6 MED7 SCD ZNF141 HDAC1 ZNF382 SETD1B SETD1A SIN3A ZNF136 EHMT2 EHMT1 PHF20 ASH2L UBE2I ZNF28 AJUBA ZNF273 HCFC1 CCNH PPARGC1A PPARGC1B POLR2E ZNF264 POLR2F POLR2H POLR2K POLR2L GTF2H1 ZNF30 GTF2H2 ZNF257 GTF2H3 EZH2 GTF2H4 ZNF33A GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB ZNF331 MED16 ACTL6A MED17 MED12 MED14 MED13 KAT2B KAT2A MED10 ZNF324 MEN1 ZNF320 MED27 SIRT1 ZNF317 MED23 MCRS1 MED24 MED20 ABL1 ZNF547 ZNF224 MBD3 GATAD2B GATAD2A SUDS3 CDK8 CDK5 ZNF778 TADA3 ZNF454 OGT SIN3B WDR5 PSIP1 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 RB1 RBBP4 RBBP5 RBBP7 SMARCE1 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 CEBPA KMT2A H3C15 TDG RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 DEK H2AC20 ZNF418 HDAC3 GPS2 LIPE TBL1X ZNF354A DGAT2 NCOA1 ZNF649 FABP4 NCOR2 NCOR1 CHD3 TBL1XR1 LPIN1 MGLL CBX3 SUMO2 RRP8 SAP130 PLIN1 DPF1 HDAC2 PDK4 DPF2 KAT8 DPF3 SAP30BP HCFC2 SUZ12 WDR82 PAXIP1 PEX11A BAZ2A CBX5 KAT14 SETDB1 SS18L1 SMARCA5 ZZZ3 ARID1A TADA2A GSK3B ARID1B ZNF816 EZH1 PHF1 SUV39H1 SGF29 CD36 JARID2 NCOA2 ZNF610 SS18 NCOA6 SMARCB1 NCOA3 CCNC TET2 TET1 SF3B1 PPHLN1 BAZ1B TRIM28 PHF20L1 NR5A2 AEBP2 MTF2 TET3 PLIN4 PLIN2 MBD2 SMARCC1 MYBBP1A SMARCC2 MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 MTREX TASOR MBIP ZNF708 TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C SMARCA2 BCL7B SMARCA4 DNMT3B UBTF ZNF765 KDM6A DNMT3A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 95%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes PPARGC1A GCK FBXO32 G6PC1 CAT INS ABCA6 HDAC1 RETN POMC NPY SIN3A SOD2 PLXNA4 PCK1 NR3C1 FOXO4 ATXN3 TRIM63 SMAD2 SMAD4 AGRP SMAD3 FOXO6 FOXO1 HDAC2 IGFBP1 SIRT3 FOXO3 SREBF1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.4 Inhibition of TSC complex formation by PKB AKT2 TSC2 TSC1 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%1660662 Glycosphingolipid metabolism GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 HEXB ARSG HEXA ARSD B3GALNT1 GLB1L3 B3GALT4 M6PR GLB1L2 GALC GLA GLB1L GLB1 ARSB ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein PARP10 PARP6 GSK3A UBE2I PARP4 PARP16 GSK3B SUMO1 PARP9 PARP14 PARP8 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 95%9854907 Regulation of MITF-M dependent genes involved in metabolism PPARGC1A SIRT1 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170984 ARMS-mediated activation NTRK1 KIDINS220 RAP1A CRK NGF BRAF YWHAB DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 95%5579019 Defective FMO3 causes TMAU FMO3 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 95%5357801 Programmed Cell Death ITCH YWHAE YWHAQ YWHAG YWHAH UBE2L3 TNFSF10 UNC5A DAPK1 UNC5B DAPK2 DAPK3 FADD ELANE CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 APPL1 DFFB DFFA DBNL RIPK3 IL18 ACIN1 IL1A IL1B KPNB1 GAS2 PELI1 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 TICAM1 CHMP4C PKP1 CHMP4B CHMP4A LY96 SDCBP BMF MLKL BMX STK24 STK26 CHMP2B CHMP2A AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 CASP5 CASP4 PPP3R1 FLOT1 FLOT2 DNM1L DSP PDCD6IP OMA1 IRF1 OPA1 IRF2 DSG1 CHMP3 DSG3 CHMP6 CHMP7 PLEC UACA ADD1 BAK1 GZMB CDKN2A MAGED1 CTNNB1 MAPK8 BCL2L11 BAD CDH1 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 BBC3 UBC PSMB1 DSG2 RPS27A PRKN ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 PAK2 CASP9 CASP7 APAF1 DIABLO CASP3 XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC OGT TRAF2 HSP90AA1 KPNA1 CDC37 BIRC2 BIRC3 E2F1 TFDP1 TFDP2 ARHGAP10 AKT2 TP53BP2 OCLN TNFRSF10B TNFRSF10A STAT3 DYNLL1 DYNLL2 MAPK1 PPP1R13B TJP1 FAS FASLG MAPK3 PMAIP1 SATB1 CASP6 CASP1 APC STUB1 BAX TP63 BCL2 BCL2L1 SEM1 TP73 PTK2 AKT3 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 95%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IFNG NFATC2 RUNX1 TNFRSF18 CTLA4 CBFB IL2RA FOXP3 IL2 CR1 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SOS1 UBC RPS27A HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS GAB1 PIK3CA UBB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis SRD5A3 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS GLB1 NUDT14 ST6GAL1 ST6GAL2 ALG5 SLC35C1 RENBP DHDDS DPM1 DPM2 DPM3 MVD ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1 AKT1 AKT2 AKT3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSENEN NCSTN YWHAZ APH1B PSEN2 ADAM10 PSEN1 JAG1 APH1A DLL4 NOTCH4 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 95%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 AURKA PSMD14 PSMD13 PSMA7 PSMB6 FBXL18 FBXL7 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 CUL1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism HSPG2 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 IDUA EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 CTSL HPSE IDS THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DUOX1 TPO IYD DUOXA1 CGA DUOXA2 DUOX2 TSHB DIO1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 95%8878159 Transcriptional regulation by RUNX3 YAP1 TCF7L2 CDKN1A TCF7L1 SPP1 CDKN2A LEF1 TCF7 TGFB1 CCND1 MAMLD1 CTNNB1 BCL2L11 ITGAL RBPJ ITGA4 SMAD4 SMAD3 SMURF2 ZFHX3 SNW1 MYC SMURF1 HDAC4 TEAD1 SRC MDM2 TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 BRD2 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 CCN2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 KRAS PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A KAT2B KAT2A EP300 JAG1 ADRM1 WWTR1 PSMC5 PSMC6 SEM1 PSMC3 RUNX1 PSMC4 PSMC1 RUNX3 PSMC2 TP53 MAML3 FOXO3 CBFB NOTCH1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210990 PECAM1 interactions LCK FYN PECAM1 LYN INPP5D PTPN6 PLCG1 ITGB3 YES1 PTPN11 ITGAV LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702998 linifanib-resistant FLT3 mutants FLT3 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 ARHGEF6 BTK GNGT1 RHOA GNGT2 CDC42 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PAK1 PDPK1 PLCB3 PLCB1 GNG10 PLCB2 AKT1 GNG12 AKT3 GNG11 INTERLEUKIN-12 SIGNALING%REACTOME%R-HSA-9020591.3 Interleukin-12 signaling IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 JAK2 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 P4HB PPIA SNRPA1 PAK2 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME%R-HSA-5654733.3 Negative regulation of FGFR4 signaling CBL UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK DAG AND IP3 SIGNALING%REACTOME%R-HSA-1489509.4 DAG and IP3 signaling PRKCA ADCY9 ADCY4 ADCY3 ADCY2 PLCG1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA CALM1 CAMK2G PRKCD DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 95%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets RPS6KA1 PPP2CA DUSP4 PPP2CB DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MEF2C MAPK7 MAPK14 MAPK11 MAPK1 ELK1 MAPK3 MEF2A RPS6KA3 RPS6KA5 PPP2R1B PPP2R1A RPS6KA2 LIPOPHAGY%REACTOME DATABASE ID RELEASE 95%9613354 Lipophagy PRKAG3 PLIN2 PLIN3 HSPA8 PRKAB2 PRKAA2 PRKAG1 PRKAB1 PRKAG2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions COL18A1 ITGA3 ITGB4 LAMA5 ITGA1 LAMA2 NID1 LAMB3 NID2 LAMC3 ITGA6 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 ITGA2 HSPG2 ITGA7 ITGB1 ITGAV BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-HSA-196780.3 Biotin transport and metabolism PDZD11 MCCC2 BTD SLC5A6 PC ACACA PCCA HLCS MCCC1 PCCB ACACB SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 95%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 SEC11A SEC11C GATA4 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME%R-HSA-156711.4 Polo-like kinase mediated events FOXM1 WEE1 LIN52 PLK1 CCNB1 EP300 CDC25C CENPF CDC25A RBBP4 CCNB2 LIN54 LIN37 MYBL2 LIN9 PKMYT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 95%2299718 Condensation of Prophase Chromosomes H2BC9 H2AZ2 H4C9 PLK1 H2BC8 H2BC5 H2BC3 H3-4 CCNB1 H2BC1 H2AC20 RB1 CDK1 SET H2AX H2AB1 NCAPG2 H2AC19 SMC4 H2BC26 SMC2 H2AC14 H2BC12L NCAPH2 H2BC21 NCAPD3 MCPH1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT5A H3C15 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 95%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918438 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis CCT6A STAT3 FBXL3 FBXL5 WRAP53 HDAC3 CCT2 KIF13A CCT3 SPHK1 SKIC2 CCNE2 TCP1 GBA1 CCNE1 DCAF7 CCT6B USP11 CCT7 FBXO4 AP3M1 LONP2 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 CCT8 CCT5 CCT4 FBXW2 NOP56 ARFGEF2 XRN2 GAPDHS FKBP9 TP53 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.2 Regulation of RUNX1 Expression and Activity PML TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 SRC TNRC6A TNRC6B CCND3 RUNX1 CCND2 CCND1 CDK6 CBFB PTPN11 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9012999 RHO GTPase cycle KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 CFTR STAM ACTB USP9X CCT6A TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 WWP2 WDR11 LETM1 TMEM59 VMA22 GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 ARMCX3 PKP4 RASAL2 STIP1 ACTG1 DDRGK1 PLXNA1 ANKRD26 NSFL1C CPD PLXNB1 ARHGAP11A ZNF512B CAPZB EFHD2 NCK2 DAAM1 WDR6 NCK1 DST PLEKHG6 NIPSNAP2 BLTP3B PARD6B SH3BP1 WHAMM WASF3 NDUFA5 PCDH7 SEMA4F SRGAP2 PTPN13 VAPB ATP6AP1 GOLGA3 CKB BAIAP2L2 KCTD13 FRS2 TMEM87A DIAPH1 GRB7 PIK3CA PIK3R3 SCFD1 DIAPH3 ITGB1 SPTBN1 CCDC88A ANLN FAF2 SOS1 KIF14 SH3RF1 NUDC AKAP12 HINT2 RAC2 MUC13 RHOG PIK3R2 RHOH PIK3R1 RHOF RHOC RHOJ RHOD RHOU RHOV RHOQ RHOA SAMM50 RHOB EMC3 MTX1 CAVIN1 MYO9A TRIP10 RTKN PRAG1 SYDE2 BASP1 ALDH3A2 ELMO2 DDX4 ARHGEF28 ARHGAP19 ARHGAP18 TOR1AIP1 ARHGAP12 CDC42 PLD2 RHPN1 RHPN2 FAM83B ACBD5 MACO1 ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 DLG5 PICALM FMNL3 SRC DOCK5 DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 SOWAHC MTR TNFAIP1 RND2 RND3 RND1 CKAP4 SENP1 ZAP70 GFOD1 ALS2 PEAK1 NDUFS3 DOCK2 DOCK1 CCDC187 MOSPD2 FAM169A ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CSK FRS3 JAG1 LCK DBT CLTC HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP LAMTOR1 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 ARHGAP21 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 ARHGAP27 ARHGAP24 ARHGAP33 ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARFGAP3 ARFGAP2 ARHGAP10 CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 WAS PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 ARL13B RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CSF2 PRKCB CREBBP RUNX1 LGALS3 CBFB REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 95%9861718 Regulation of pyruvate metabolism WDR26 PDHB RMND5B LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GID4 GID8 UBC RPS27A PDK4 DLD DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.4 Defective CYP11B1 causes AH4 CYP11B1 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.4 Mitotic G2-G2 M phases CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC E2F1 RBBP4 E2F3 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 95%76005 Response to elevated platelet cytosolic Ca2+ TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PRKCB PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 PRKCA CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 PRKCG FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%419408 Lysosphingolipid and LPA receptors PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death JUN PRDX2 H2BC9 PRDX1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 CDC25B CDC25A LMNB1 BCL2L11 FASLG CDK5R1 RIPK1 CDK5 SUZ12 YWHAE TRAF2 EED CDC25C FADD GSDME C1QBP RBBP4 EZH2 GOLGA2 SOD2 CAPNS1 RIPK3 CAPNS2 CAPN2 RBBP7 CAPN1 CAST PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MLKL H2AC6 H2AC7 H2BC17 APP DNMT3B H2BC12 H2BC13 TRADD H2BC14 H2AJ DNMT3A H2BC15 TP53 CASP8 H2BC11 FOXO3 H3C15 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.2 Processing of SMDT1 STOML2 MCUB SPG7 PHB2 MAIP1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU PHB1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling EGF ERBB2 EGFR PLCG1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 95%1566948 Elastic fibre formation FBLN5 LOXL1 ITGA5 LOXL2 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 FURIN MFAP5 BMP4 MFAP4 LOX MFAP3 MFAP2 FBN1 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9609507 Protein localization SGTA PEX10 PEX12 TOMM20 GFER GDAP1 PEX13 PEX14 OTC DHRS4 NUDT7 VAPA TOMM7 CRAT TOMM5 TOMM6 NOS2 STX5 CAT SLC25A4 SLC25A6 IDE PMPCB PMPCA SLC27A2 PECR SAMM50 ZFAND6 TOMM22 MTX1 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 SCP2 CHCHD7 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 CMC4 CMC2 PAM16 ECH1 PIPOX BCS1L GNPAT ACBD5 ACOT2 STX1A ACOT4 COX19 COX17 PEX11B ATP5MC1 TIMM50 BAG6 PITRM1 GRPEL1 ABCD3 GRPEL2 UBE2D2 LDHD UBE2D3 OTOF HMOX1 HACL1 HAO1 CYC1 DECR2 HAO2 DNAJC19 COA4 PRNP FIS1 EPHX2 IDH1 TYSND1 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 UBE2D1 AMACR DAO HSPD1 PXMP2 PXMP4 ACO2 ABCD2 UBA52 CROT HSCB SERP1 SEC61G TIMM17A TIMM17B GET1 SEC61B GET3 EMD ABCD1 COA6 GET4 CAMLG TIMM23 PEX2 TIMM22 HSPA9 PEX1 TIMM21 BAAT UBB TOMM70 PEX7 SLC25A17 ACOX2 ACOX1 UBC PEX3 EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PAOX NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 APP HSD17B4 TIMM10 DDO HMGCL ATP5F1A ATP5F1B USP9X UBL4A TIMM8B ATAD1 PEX16 TIMM8A PEX19 MTX2 IDH3G DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC67A1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 95%159740 Gamma-carboxylation of protein precursors F7 F9 PROC F10 GGCX PROS1 PROZ F2 BGLAP GAS6 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 95%5610787 Hedgehog 'off' state ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L PRKACA KIF7 PRKACB WDR35 IFT88 SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 GLI3 GLI2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 GNAS PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 BTRC NUMB PSMD13 OFD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PRKAR1B PSMC5 PRKAR2B PSMC6 PRKAR1A SEM1 PSMC3 PRKAR2A PSMC4 PSMC1 PSMC2 SKP1 CUL1 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis AP2A1 AP2A2 AP2M1 ARF1 ATP6V1H CD4 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B HCK PACS1 ELMO1 RAC1 LCK CD28 FYN PAK2 DOCK2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%164944 Nef and signal transduction LCK RAC1 FYN PAK2 HCK DOCK2 ELMO1 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction PALS1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 JUN PCNA COX5B COX5A PERP NPM1 COX6C TTC5 CCNG1 PRDM1 COX6A1 COX6A2 G6PD COX6B2 COX6B1 NDRG1 HIGD1C CNOT10 CNOT11 TAF4B YWHAE PRR5 DYRK2 CHD4 TRIAP1 PIDD1 YWHAQ YWHAG ZNF385A YWHAH TBP TMEM219 TAF9 TAF1L AURKA MTA2 TAF15 TAF12 TAF13 TAF11 CARM1 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 PIP4K2A PIP4K2B PIP4K2C MAPKAP1 PRDX2 PRDX1 PLK3 PRELID1 CDKN1A HDAC1 CDKN2A PLK2 CDK2 CDK12 CDK13 PRKAA1 PRKAA2 MDC1 ATF2 BTG2 MT-CO1 PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 RPTOR NOC2L CHM STK11 TNRC6C MOV10 MLST8 TAF7L SLC38A9 AGO3 ING5 AGO4 ING2 PRKAB2 PIP4P1 AIFM2 AGO1 TNKS1BP1 AGO2 TSC2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC MT-CO2 BRD1 MT-CO3 ELOB RHEB RRAGB ELOC RRAGD LAMTOR2 AKT1 MEAF6 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SFN BRD7 YWHAZ CCNH POLR2A POLR2B PRELID3A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K TIGAR POLR2L GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 POU4F2 SUPT5H HIPK2 GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB BBC3 UBC DDB2 RPS27A CASP10 CSNK2A1 MAPK14 MAPK11 CSNK2A2 CNOT6L TAF9B CSNK2B IGFBP3 KAT6A TP53 APAF1 CYCS USP7 PLAGL1 PMS2 USP2 RICTOR BID MBD3 MAP2K6 FANCI GATAD2B GATAD2A FANCC CNOT4 CNOT6 CNOT7 BCL6 CDK5 CNOT1 STEAP3 CNOT2 CNOT3 MDM2 MDM4 CNOT8 CNOT9 CCNT2 SESN3 PTEN SESN2 KMT5A GPX2 BNIP3L CDC25C RNF34 CDKN1B NLRC4 MSH2 E2F1 RBBP4 MAPKAPK5 DAXX TFDP1 RBBP7 CCNE2 TFDP2 RFFL CCNE1 PPP2R1B TXNRD1 PPP2R1A CPAP PML TAF10 TP53RK EP300 AKT2 TP53AIP1 CHEK2 SMYD2 COX7A2L PDPK1 TXN NUAK1 TP53BP2 BANP GADD45A BCL2L14 TPX2 ZNF420 BRPF1 BRPF3 TNFRSF10C TNFRSF10B PRMT5 TNFRSF10A PPP2R5C PRMT1 TNFRSF10D RGCC SGK1 PIN1 BIRC5 MLH1 PPP1R13B COX4I1 FAS COX4I2 PPP1R13L CDK5R1 AURKB PPP2CA PPP2CB FANCD2 COXFA4 RABGGTB COX7A2 RABGGTA COX7A1 CHD3 RRM2B PMAIP1 TP53INP1 HDAC2 TP53I3 E2F4 JMY E2F7 E2F8 CASP6 CASP1 CASP2 RBL2 RBL1 GPI CCNK CCNB1 GLS2 GLS CDK1 ARID3A BAX BLM TP63 MRE11 BRCA1 CTDP1 ELL WRN BRIP1 CCNT1 KAT5 SUPT4H1 ELOA EXO1 CHEK1 NELFB NELFCD RBBP8 NELFA NBN NELFE TOPBP1 L3MBTL1 ATRIP SUPT16H BARD1 CREBBP RFC5 RMI2 ELOA2 RFC3 SSRP1 CDK9 RFC4 RMI1 TCEA1 PCBP4 RFC2 TOP3A RPA1 HUS1 RPA2 CRADD RAD50 RAD51D TP73 COX7B RPA3 RAD17 FOS RAD1 CCNA2 ATM CCNA1 DNA2 COX7C RAD9B RHNO1 ATR COX8A RAD9A COX8C AKT3 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.9 Activation of NMDA receptors and postsynaptic events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D KIF17 GRIN1 RPS6KA6 DLG1 CASK GRIN2A LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIA3 CALM1 CAMK2G GRIA4 GRIN3B GRIN3A APBA1 CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 NBEA RPS6KA3 RPS6KA2 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity USP7 USP2 RICTOR TTC5 CCNG1 MBD3 PRDM1 MAP2K6 GATAD2B GATAD2A CDK5 MDM2 MDM4 TAF4B PRR5 DYRK2 CHD4 KMT5A ZNF385A TBP TAF9 TAF1L RNF34 AURKA MTA2 TAF15 TAF12 RBBP4 TAF13 MAPKAPK5 TAF11 DAXX RBBP7 TAF8 TAF7 RFFL TAF6 TAF5 PPP2R1B TAF4 PPP2R1A TAF3 TAF2 PML TAF1 PIP4K2A TAF10 TP53RK PIP4K2B EP300 PIP4K2C AKT2 CHEK2 SMYD2 PDPK1 NUAK1 TP53BP2 BANP MAPKAP1 TPX2 BRPF1 BRPF3 PRMT5 PLK3 PPP2R5C HDAC1 CDKN2A SGK1 PIN1 CDK2 PPP1R13B PPP1R13L PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 EHMT2 PRKAG2 EHMT1 PHF20 PRKAG3 SETD9 PPP2CA NOC2L STK11 PPP2CB MLST8 CHD3 TAF7L ING5 ING2 PRKAB2 PIP4P1 TP53INP1 HDAC2 PRKAB1 MTOR JMY BRD1 AKT1 MEAF6 BRD7 UBA52 CDK1 HIPK1 POU4F1 BLM POU4F2 MRE11 TP63 HIPK2 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 SUPT16H L3MBTL1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CSNK2A2 TAF9B RAD50 CSNK2B TP73 KAT6A RPA3 RAD17 TP53 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A AKT3 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 95%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 95%1222449 Mtb iron assimilation by chelation LTF REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity XIAP RNF146 TNKS PREX2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 AKT1 PSMD1 PSMA5 STUB1 PSMA6 PSMA3 TRIM27 PSMA4 WWP2 PSMA1 NEDD4 MKRN1 PSMA2 FRK UBA52 PSMD12 USP13 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A AKT2 ADRM1 CSNK2A1 PSMC5 OTUD3 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 AKT3 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 95%5579028 Defective CYP17A1 causes AH5 CYP17A1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702636 tandutinib-resistant FLT3 mutants FLT3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 GIT1 CALM1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 95%2514859 Inactivation, recovery and regulation of the phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells KCNN2 KCNMA1 KCNMB1 CHRNA9 CHRNA10 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MLH1 RPA3 EXO1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006927 Signaling by Non-Receptor Tyrosine Kinases GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B NAGLU MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) STPG4 METTL23 YAP1 UHRF1 H2BC9 DPPA4 H2AZ2 DPPA3 H4C9 DPPA2 H2BC8 ZFP36L2 H2BC5 LEUTX H2BC3 PAIP1 NPM2 H2BC1 KDM4E TPRX1 AICDA SRPK1 H2AC20 H1-8 TPRX2 ZSCAN4 HIRA CNOT4 CNOT6 CNOT7 EIF4E DICER1 EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 CNOT11 KDM5B TEAD4 PABPN1 PABPC1 TET3 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 BTG4 CNOT6L EIF4A2 H2BC12 KDM5A H2BC13 EIF4A1 H2BC14 TUT7 KDM6A H2AJ TUT4 H2BC15 EIF4G1 DUX4 TP53 PABPN1L H2BC11 TPRXL EIF4A3 DUXA DUXB DIS3L2 KDM6B PRM2 PRM1 H3C15 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission RPS6KA1 GNG13 GNB2 GNB1 AP2A1 ADCY9 GNB4 GNAL GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 CHRNA9 RASGRF2 PRKAR1B PRKAR2B PRKCB PRKAR1A RAC1 HRAS PRKAR2A PRKX PDPK1 PLCB3 PLCB1 PLCB2 ARHGEF9 NRAS GRIP1 MAPK1 GNAT3 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 CHRNA1 CHRNA3 PRKAA1 CHRNA2 PRKAA2 MAPK3 CHRNA5 CHRNA4 CHRNA7 PRKAG1 CHRNA6 PRKAG2 EPB41L1 PRKAG3 TSPAN7 GABRB3 GABRB2 GABRB1 GRIK5 GRIK3 GRIK4 GRIK1 PRKAB2 GRIA1 GRIK2 GABRR3 CAMK2B GRIA2 GABRR2 GABRR1 CAMK2D NPTN SRC ACTN2 PRKAB1 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B NRGN PICK1 GRIN2D GNAI3 AKAP5 GRIN1 DLG1 GNAI1 GRIN2A NCALD DLG2 GNAI2 DLG3 CHRND LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE PRKCA CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 GIT1 KCNJ16 GLRB CAMK4 CAMKK1 CAMKK2 KPNA2 PRKCG GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade RHO PDE6G CNGA1 GNB1 GNAT1 SLC24A1 SAG PDE6B CNGB1 GNGT1 PDE6A DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 95%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 EED H2BC3 H2BC1 H2AC20 GSDME RBBP4 EZH2 RBBP7 PRIM2 PRIM1 H2AX POLA1 POLA2 DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 95%9909396 Circadian clock FBXL3 CDK5 RORC RORA RORB SMARCD3 BTRC CARM1 PPP1CC NAMPT EP300 MED1 KMT2A RXRA SERPINE1 HDAC3 NR1D1 NRIP1 TBL1X BMAL1 NCOA1 ATF2 NCOR1 MEF2C TBL1XR1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PPARGC1A PSMA6 PSMA3 UBE2D1 NCOA2 PSMA4 PSMA1 NCOA6 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PPP1CA PSMD13 PSMA7 PSMB6 CRTC2 PSMB7 CRTC3 CRTC1 CSNK1D PSMB4 CPT1A PPP1CB SIK1 PSMB5 CSNK1E CLOCK NPAS2 UBB HELZ2 PSMB2 RAI1 PSMB3 CREBBP BHLHE40 UBC CHD9 BHLHE41 PSMB1 RBM4 DBP RPS27A TFEB KLF15 FBXW11 CRY2 CRY1 AVP CIPC ADRM1 CSNK2A1 FBXL21P NOCT TGS1 PSMC5 CSNK2A2 MEF2D PSMC6 SEM1 PER2 PSMC3 PER1 PSMC4 F7 PER3 PSMC1 CSNK2B PSMC2 BMAL2 SIRT1 SKP1 SREBF1 CUL1 PPARA REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 95%191650 Regulation of gap junction activity GJA1 TJP1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 95%9603381 Activated NTRK3 signals through PI3K NTRK3 NTF3 PIK3R1 PIK3CA SRC IRS1 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%5619115 Disorders of transmembrane transporters SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L KCNJ11 SLC5A1 ABCC8 SLC5A2 ABCC9 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 SLC67A1 RNF185 SLC26A3 APOA1 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 VCP SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC6A19 SLC27A4 SLC36A2 SLC6A14 SLC7A7 SLC7A9 GCKR GCK ABCA1 ABCG8 ABCG5 ABCA3 PSMD8 PSMD6 HK1 PSMD7 PSMD2 PSMD3 PSMD1 NUP214 SLC5A5 PSMA5 SLC35C1 PSMA6 CFTR PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 SLC24A1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 SLC17A5 RPS27A SLC9A6 AVP ADRM1 SLC9A9 PSMC5 PSMC6 SEM1 SLC35A1 PSMC3 PSMC4 PSMC1 PSMC2 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes CREBBP ATF4 MAFK NFE2L2 EP300 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane ARL13B INPP5E PDE6D CCT2 CCT3 SMO TCP1 ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP HDAC6 BBIP1 RHO RAB11A ATAT1 TTC8 CNGB1 RAB8A SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CCND1 MAMLD1 RBPJ TNRC6C MOV10 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B ELANE E2F1 E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation BRD7 BRPF1 BRPF3 HDAC1 MTA2 PIN1 RBBP4 MBD3 MAP2K6 RBBP7 GATAD2B GATAD2A PML CHD3 ING5 PIP4K2A ING2 PIP4K2B PIP4P1 EP300 PIP4K2C AKT2 HDAC2 BRD1 KAT6A TP53 CHD4 MEAF6 AKT1 AKT3 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM NCBP1 NCBP2 FGF1 POLR2A FGF2 POLR2B FGFR2 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB ZFP36 DCP1A EXOSC7 EXOSC6 EXOSC5 TNPO1 EXOSC4 DIS3 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) PCNA YY1 RUVBL1 PARP1 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 RBX1 NFRKB CCNH ACTR5 RAD23A ACTR8 RAD23B CETN2 UBA52 INO80 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB UBB TFPT ACTL6A LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 DDB2 POLD1 RPS27A POLE POLD2 PIAS3 RFC2 RFC1 PARP2 USP45 LIG3 RPA1 RNF111 CHD1L DDB1 RPA2 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 COPS6 COPS5 MCRS1 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 95%75102 C6 deamination of adenosine ADAR ADARB1 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.4 Defective CHST3 causes SEDCJD NCAN CSPG4 CHST3 BGN DCN BCAN VCAN CSPG5 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 95%5632968 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.7 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BID BBC3 BCL2 BCL2L11 STAT3 PMAIP1 BCL2L1 BAD BMF DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 95%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism ACSS3 BDH2 BDH1 HMGCL OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%8941326 RUNX2 regulates bone development YAP1 RBM14 HES1 BGLAP ABL1 RB1 MAF HDAC3 COL1A1 MAPK1 HDAC6 SP7 IHH UCMA MAPK3 GLI3 SMAD1 GLI2 SMAD4 HEY1 HEY2 SMAD6 HDAC4 SRC WWTR1 YES1 SATB2 CBFB ZNF521 AR OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956551.1 OTC leader sequence variants cause OTC deficiency OTC HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 95%3371497 HSP90 chaperone cycle for SHRs FKBP5 HSP90AA1 DYNLL1 DCTN6 DCTN5 ACTR1A HSP90AB1 DCTN1 DYNLL2 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 CAPZA3 DNAJA4 DNAJA2 CAPZA2 DYNC1I2 FKBP4 NR3C1 ACTR10 STIP1 HSPA1B CAPZB DYNC1LI1 DYNC1I1 DYNC1LI2 DCTN2 HSPA8 DYNC1H1 CAPZA1 DCTN3 HSPA1A PGR AR REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling IFNG JAK2 JAK1 SOCS3 PTPN6 PIAS1 PTPN1 SOCS1 SUMO1 IFNGR1 IFNGR2 PTPN11 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 95%3560801 Defective B3GAT3 causes JDSSDHD CSPG4 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 B3GAT3 CSPG5 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 95%8878166 Transcriptional regulation by RUNX2 YAP1 BGLAP ABL1 IHH NR3C1 ESRRA STAT1 MSX2 SMAD1 SMAD4 ESR1 BMP2 ZNF521 RBM14 RB1 MAF HDAC6 SKP2 CDK4 DLX5 DLX6 AKT2 SOX9 RUNX1 TWIST2 TWIST1 CBFB ITGA5 CDKN1A HDAC3 MAPK1 CCND1 SP7 MAPK3 NKX3-2 GLI3 GLI2 HAND2 PPM1D SMURF1 SMAD6 HDAC4 SRC SATB2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B AR PSMA5 STUB1 PPARGC1A PSMA6 PSMA3 PSMA4 PPARGC1B PSMA1 CCNB1 PSMA2 HES1 LGALS3 UBA52 PSMD12 PSMD11 CDK1 COL1A1 PSMD14 WWP1 BAX PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UCMA PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 HEY2 HIVEP3 ADRM1 WWTR1 YES1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 ITGBL1 PSMC2 SKP1 MMP13 CUL1 AKT3 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 95%193639 p75NTR signals via NF-kB IKBKB SQSTM1 UBC MYD88 RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR PRKCI UBB RIPK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 95%9674403 Regorafenib-resistant PDGFR mutants PDGFRA DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 SKP2 CCNE2 KPNB1 PRIM2 CCNE1 PRIM1 POLA1 H2AX POLA2 LIG1 H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 KPNA6 POLRMT POLG2 RNASEH1 FEN1 MCM10 POLG TWNK DBF4 MGME1 EXOG RPA4 SSBP1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 TOP3A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S EIF2S2 EIF2S1 EIF2S3 EIF4EBP1 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 95%69190 DNA strand elongation PCNA GINS1 GINS2 CDC45 GINS3 GINS4 PRIM2 PRIM1 POLA1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 MCM7 MCM8 RPA3 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 95%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RRAS FES PLXNA2 TLN1 PIP5K1C FARP2 PLXNA3 RAC1 FYN RND1 PLXNA4 NRP1 PLXNA1 SEMA3A ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 95%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 KERATINIZATION%REACTOME DATABASE ID RELEASE 95%6805567 Keratinization PERP PI3 CAPNS1 CAPN1 PKP1 DSP DSG1 DSG3 LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G DSG2 KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 FURIN PCSK6 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KRT12 KLK14 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 JUP KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PKP4 LELP1 KRTAP4-1 KRTAP12-1 KRTAP12-3 KRTAP12-2 KRTAP4-9 KRTAP4-8 KRTAP12-4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 CELA2A KRTAP5-9 KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 KRTAP6-3 KRTAP21-1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%5661270 Formation of xylulose-5-phosphate DCXR AKR1A1 SORD CRYL1 XYLB IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 95%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 95%2470946 Cohesin Loading onto Chromatin PDS5B SMC1A SMC3 PDS5A WAPL MAU2 STAG1 NIPBL STAG2 RAD21 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines H2AZ2 H4C9 PRMT6 PRMT5 SMARCB1 SMARCD1 PRMT1 SMARCD2 SMARCD3 H2AC20 H2AC1 H2AC25 H2AC21 CCND1 JAK2 SMARCC1 SMARCC2 PRMT7 PRMT3 CARM1 RBBP7 WDR77 COPRS CDK4 ARID2 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2AC14 RPS2 H3C8 H2AC8 H2AC6 H2AC7 SMARCA2 ACTL6B SMARCA4 H2AC17 H2AC12 H2AJ DNMT3A WDR5 ARID1A ARID1B H3C15 PBRM1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IPPK IPMK IP6K1 IP6K2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PI4K2B MTMR10 MTMR2 MTMR12 PIK3C2A MTMR4 MTM1 PIK3R4 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PIK3C3 VAC14 PTK6 DOWN-REGULATION%REACTOME%R-HSA-8849472.2 PTK6 Down-Regulation PTK6 PTPN1 SRMS EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis RASGRP2 RASGRP1 ITPR1 ITPR2 MGLL ITPR3 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 TRPC7 ABHD12 PRKCH TRPC6 DGKZ DGKQ PRKCQ TRPC3 PRKCE DAGLB DGKK DGKI DGKH PRKCD RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 95%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 95%200425 Carnitine shuttle RXRA MID1IP1 SLC22A5 SLC25A20 CPT1B PPARD PRKAB2 CPT1A PRKAA2 CPT2 PRKAG2 THRSP G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events TIAM1 GNG13 ARHGEF9 SOS1 OBSCN GNB2 ARHGEF3 ARHGEF4 GNB1 ARHGEF1 ARHGEF2 ARHGEF7 GNB4 SOS2 GNB3 RHOC ARHGEF5 NGEF GNB5 ARHGEF6 ARHGEF26 GNGT1 RHOA KALRN RHOB FGD1 FGD2 GNGT2 ROCK1 GNA13 ROCK2 FGD3 ABR FGD4 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 GNG3 GNG2 GNG5 GNG4 TBXA2R GNG7 GNG8 BTK GNA12 PLXNB1 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 GNG10 ADRA1D ARHGEF16 ARHGEF19 ADRA1B ARHGEF18 VAV1 ADRA1A VAV2 GNG12 TIAM2 GNG11 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.4 IkBA variant leads to EDA-ID IKBKB NFKB2 RELA CHUK NFKB1 NFKBIA IKBKG SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids HSD17B4 EHHADH ABCD1 DECR2 SLC27A2 ACOT4 ACAA1 ACOT8 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9701898 STAT3 nuclear events downstream of ALK signaling DNMT1 SIN3A STAT3 PRDM1 EP300 CD274 HDAC1 IL2RG HIF1A HDAC2 HDAC3 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PIK3CB STRN SOS1 KDR FIP1L1 STAT3 PIK3R2 PIK3R1 NRAS PDGFRA HRAS WDR48 STAT1 PIK3CA KANK1 ETV6 GOLGA4 BIN2 SIGNALLING TO ERK5%REACTOME%R-HSA-198765.3 Signalling to ERK5 MAP2K5 MAPK7 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.2 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 SIGNALING BY RETINOIC ACID%REACTOME DATABASE ID RELEASE 95%5362517 Signaling by Retinoic Acid RXRA PPARD DHRS4 PDHB RXRG PDK3 DLAT RXRB PDK2 PDK1 PDHX PDHA2 PDHA1 RARG FABP5 CYP26A1 CYP26B1 CYP26C1 ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 PDK4 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 RARB ALDH8A1 RARA DLD ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 95%2426168 Activation of gene expression by SREBF (SREBP) RXRA GGPS1 SCD CYP51A1 FASN LSS SREBF2 SQLE NCOA2 MTF1 DHCR7 NCOA6 SMARCD3 ACACB GPAM NFYA MVD NFYB NFYC TBL1X CARM1 NCOA1 HELZ2 CREBBP CHD9 SP1 TBL1XR1 ACACA MED1 TGS1 IDI1 MVK ELOVL6 TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA MRNA CAPPING%REACTOME DATABASE ID RELEASE 95%72086 mRNA Capping RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%2173788 Downregulation of TGF-beta receptor signaling NEDD4L STUB1 PMEPA1 BAMBI STRAP UBA52 TGFB1 TGFBR1 TGFBR2 PPP1CA USP15 PPP1R15A PPP1CB PPP1CC UBB UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD3 SMURF2 SMAD7 SMURF1 XPO1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%9840310 Glycosphingolipid catabolism ARSB GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 GBA1 NEU2 ENPP7 NEU3 ARSA SUMF2 SUMF1 NEU1 ASAH1 ASAH2 ARSL ARSJ ARSK PSAP ARSH ARSI CTSA ARSF HEXB ARSG HEXA ARSD GLB1L3 M6PR GLB1L2 GALC GLA GLB1L GLB1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 WWP2 EGF HES1 EGFR WWC1 NEURL1B UBA52 DLGAP5 HES5 PLXND1 APH1A PTCRA DLL4 MIB2 PSENEN PBX1 NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 TACC3 MAMLD1 PSEN1 STAT1 UBB RBPJ CREBBP UBC MAML2 FABP7 MAML1 RPS27A YBX1 HEY1 KAT2B KAT2A EP300 JAG2 SNW1 HEY2 JAG1 DLL1 MAML3 NOTCH3 NOTCH1 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS AP2A1 AP2A2 FURIN SAP30L AP2M1 ATP1B3 ATP1B2 ROCK1 ATP1B1 ROCK2 CUL3 IGHV3-23 ARID4A IGLV MBD3 COMT IGLV2-8 NR3C1 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 GATAD2B IGHV3-30 RIPK1 GATAD2A IL1R1 SUDS3 IGHV3-33 AP2S1 IGKV1D-39 ZBP1 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 TBK1 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 FXYD4 PHF21A FXYD3 CD79B IGLV2-11 FXYD2 CD79A IGLV1-40 FXYD1 IGLV1-47 IGLV6-57 FXYD7 IGLV2-14 FXYD6 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CHD4 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV SAP18 IGKV2-29 IGKV2-28 IGLC3 ATP1A4 BLNK ATP1A3 HMG20B MTA2 IGLC1 ATP1A2 FNTB IGLC2 S1PR1 JAK3 ATP1A1 SIGMAR1 RBBP4 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 REST IGLV3-19 MTA3 IGHV2-70 RBBP7 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FNTA BRD4 CRBN IGLC7 IGHV3-53 IGKV5-2 NCK1 STAT2 IGLC6 IL6R IGKV1-5 IMPDH1 IMPDH2 PDCD1 ITGB1 VAV1 TLR9 SOS1 HDAC1 HSP90AB1 KDM1A PTGES3 FKBP4 IFNGR1 IFNGR2 ITGA4 CHD3 HDAC2 FKBP1A KEAP1 RBX1 BTK JAK2 TUBB ARID4B JAK1 SAP30 TYK2 NFE2L2 SYK SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 95%400685 Sema4D in semaphorin signaling RRAS PLXNB1 ERBB2 RHOC ARHGAP35 SEMA4D RHOA LIMK2 RHOB LIMK1 RAC1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MET MYH10 MYL9 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 95%8986944 Transcriptional Regulation by MECP2 FKBP5 HTT HDAC1 GAD1 SGK1 GAD2 HDAC3 GPS2 SIN3A PRKACA MET TBL1X DGCR8 PTPN1 AURKB NCOR2 TNRC6C GPRIN1 MOV10 NCOR1 MEF2C TBL1XR1 AGO3 IRAK1 AGO4 RBFOX1 CAMK2B GRIA2 AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A GRIN2B PTEN SLC2A3 GRIN2A TRPC3 OPRM1 SST CALM1 CAMK2G PTPN4 CRH OPRK1 LBR HIPK2 PVALB FOXG1 SOX2 MOBP GAMT DLL1 CAMK4 BDNF PPARG CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 95%983169 Class I MHC mediated antigen processing & presentation MIB2 ITCH HSPA5 SAR1B TLR1 S100A9 S100A8 TLR2 STX4 UBE2L3 CD14 BTRC TLR4 LY96 RNF111 UBE2V2 LRR1 HMGB1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SEC31A SOCS1 HACE1 SIAH1 LNPEP MEX3C IKBKB UBAC1 FBXL8 MYD88 CD207 CALR CANX FBXL4 DZIP3 RNF220 DET1 LRSAM1 CTSS MRC2 TRIM9 MRC1 ARIH2 LRRC41 VAMP8 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 TLR6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 PSMB8 PSMB9 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 NCF1 KLHL5 PSMA5 RLIM NCF2 PSMA6 TRIP12 NCF4 PSMA3 KBTBD7 SNAP23 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 BTK RNF19B UBE3A PSMD12 SEC61G UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 SEC61B NPEPPS PSMD13 RNF19A PSMA7 PDIA3 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 S100A1 UBE2E3 CYBB TRIM4 PSMB4 FBXO17 TAP2 CYBA PSMB5 FBXO15 IKBKG UBE2E2 TAP1 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 VAMP3 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 PSME2 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 CUL3 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 RBBP6 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 SMURF2 ASB13 B2M ASB14 ASB11 RNF6 ASB12 HLA-A RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 SEC13 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 BECN1 SEC24D ASB2 ASB3 SEC24C SKP2 ASB1 CDC20 SOCS3 PIK3C3 ITGAV SH3RF1 ITGB5 PIK3R4 FBXO32 CHUK MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 CD36 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FGB FGA FGG FBXW11 FBXL21P SEM1 SKP1 CTSV CTSL CUL1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 95%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 95%9635486 Infection with Mycobacterium tuberculosis ENO1 TRIM27 KPNA1 UBA52 ATP6V1H MAPK1 CTSG DUSP16 VPS33B CORO1A PGK1 HGS RNF213 RAB5A KPNB1 MAPK3 UBB UBC RPS27A RAB7A B2M SFPQ MRC1 NOS2 LTF TLR2 GSK3A INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR HBEGF TGFA AREG EGF EGFR EREG BTC EPGN SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 FGF1 FGF2 FGF23 FGF4 FGFR1 FGF6 FGF9 FGF20 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772573.4 Late SARS-CoV-2 Infection Events FURIN RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX ACE2 MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 ANO8 CSNK1A1 PARP14 ANO9 PARP8 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 UBA52 ST6GALNAC3 ST6GALNAC4 TMPRSS2 SRPK2 ANO10 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-HSA-419812.5 Calcitonin-like ligand receptors CALCRL ADM2 ADM IAPP RAMP1 RAMP2 CALCA RAMP3 CALCB CALCR DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 95%3359485 Defective CD320 causes MMATC TCN2 CD320 LATE PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162599.4 Late Phase of HIV Life Cycle FURIN CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TBP NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 RANGAP1 TAF7L ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 95%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 95%9662001 Defective factor VIII causes hemophilia A F9 F10 TPST2 TPST1 F8 F2 VWF NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 95%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors COL4A2 COL4A1 FTH1 SCGB3A2 MASP1 CALR FTL COL1A1 APOA1 COL1A2 APOB APOE COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 95%162592 Integration of provirus BANF1 XRCC6 XRCC4 KPNA1 XRCC5 LIG4 PSIP1 PPIA HMGA1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol MKRN1 CDKN1A AKT2 TSC2 MDM2 CDKN1B CHUK AKT1S1 GSK3A AKT1 CASP9 BAD GSK3B AKT3 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 95%3214815 HDACs deacetylate histones H2BC9 H4C9 H2BC8 H2BC5 H2BC3 SAP30L H2BC1 HDAC1 H2AC20 H2AC1 HDAC3 KDM1A GPS2 ARID4A MBD3 TBL1X GATAD2B GATAD2A SUDS3 NCOR2 CHD3 BRMS1 NCOR1 TBL1XR1 HDAC2 PHF21A H2AC17 H2AC12 CHD4 RCOR1 H2BC18 SAP18 HMG20B HDAC8 MTA2 H2AC25 H2AC21 RBBP4 MTA1 REST ARID4B MTA3 RBBP7 SAP30 H2AC19 H2BC26 H2AC14 H2BC21 HDAC10 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665686.3 Signaling by ERBB2 TMD JMD mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 EGFR CDC37 NRAS PLCG1 NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 95%9909615 Regulation of PD-L1(CD274) Post-translational modification SEL1L RPN2 ERLIN1 TUSC3 PDCD1LG2 ERLIN2 B3GNT3 RPN1 SPOP MAGT1 MIB2 RNF185 CCND1 CUL3 VCP OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 DERL3 DERL1 OSTC DERL2 RNF5 ERLEC1 STT3A OS9 STT3B PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B YWHAG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PDCD1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 COPS5 CUL1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 95%3595174 Defective CHST14 causes EDS, musculocontractural type NCAN CSPG4 BGN DCN BCAN VCAN CHST14 CSPG5 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918443 Defective visual phototransduction due to OPN1SW loss of function OPN1SW E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 H2BC3 PEX14 H2BC1 HLA-B RNF20 VCP UBE2J2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC UBA52 PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PEX2 UBB UBC RPS27A UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2B UBE2N PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 95%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex CDK5 CRY2 CRY1 CSNK2A1 CSNK2A2 PER2 PPP1CA PER1 PER3 CSNK2B CSNK1D PPP1CB CSNK1E PPP1CC HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 95%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT SHH IHH DHH TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME%R-HSA-168142.3 Toll Like Receptor 10 (TLR10) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5603037 IRAK4 deficiency (TLR5) IRAK4 MYD88 TLR10 TLR5 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 95%418885 DCC mediated attractive signaling CDC42 DCC NTN1 TRIO NCK1 SRC RAC1 ABLIM1 WASL ABLIM2 PTK2 ABLIM3 DOCK1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 95%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP RSV-HOST INTERACTIONS%REACTOME%R-HSA-9833110.2 RSV-host interactions IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 HSPG2 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L CD209 SDC4 SDC2 SDC3 CDK8 AGRN TLR3 IRF3 GPC1 IFNAR1 GPC3 MAVS GPC2 GPC5 GPC4 GPC6 RIGI TLR6 ELOB TLR2 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 CD14 BECN1 TLR7 IFIH1 JAK1 TLR4 UBB MED16 BCAP31 MED15 MED17 CREBBP UBC MED12 TYK2 MED14 MED13 RPS27A MED10 STAT2 EP300 CUL5 LY96 MED1 MED30 MED31 MED8 MED4 MED27 MED6 MED26 MED7 H2BC15 MED23 UBE2L6 MED25 IFNA5 HERC5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NOP2 HSPD1 TFAP2A NPM1 MYBL2 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 APEH RPL7A RPL18A HEMK2 RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 TRMT112 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 CHAC1 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME DATABASE ID RELEASE 95%9029569 LXRs regulate gene expression linked to cholesterol transport and efflux RXRA CETP KDM3A HDAC3 KDM1A KDM1B GPS2 RXRB APOD APOE TBL1X NCOA1 ABCA1 ABCG8 KDM4A ABCG5 NR1H2 APOC4 NR1H3 NCOR2 ARL4C TNRC6C MOV10 EEPD1 NCOR1 AGO3 TBL1XR1 AGO4 EP300 APOC2 APOC1 AGO1 AGO2 TNRC6A ABCG1 TNRC6B NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 95%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 95%5578768 Physiological factors NKX2-5 KAT2B WWTR1 HIPK1 HIPK2 MME NPR1 NPR2 TBX5 NPPC CORIN CES1 GATA4 NPPA CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 95%69278 Cell Cycle, Mitotic PCNA YWHAE EML4 CDCA5 MYBL2 NCAPG YWHAG ARPP19 NCAPH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 CHMP3 CHMP6 CHMP7 CDC7 FBXL18 FBXL7 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH LYN CDKN2B CDK7 MNAT1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 ABL1 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 JAK2 PPP1CB HJURP RFC5 PPP2R2A RFC3 PPME1 GTSE1 RFC4 BORA FKBPL RFC2 FBXW11 OPTN OBI1 HMMR RPA1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B TICRR MCM7 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 DNA2 MCM4 MCM5 MCM6 MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MYC PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 HAUS8 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 KMT5A HSP90AA1 CDC25C CDKN1C RB1 CDKN1B CCND3 FZR1 CCND2 E2F1 E2F2 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX CPAP LIG1 MAX H2AB1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 RCC1 H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 GSK3B PHLDA1 AKT3 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176814 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation UPK1A EPCAM METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 95%556833 Metabolism of lipids ACSS3 MED19 SLC22A5 ABCB4 MED18 MED11 AGPAT2 SLCO1B1 SLCO1B3 MED9 MED29 MED28 MED22 MED21 THRSP GPAM GAL3ST1 CERK GBA3 CDK19 GBA2 SMPD3 SMPD2 STS SMPD4 MED13L GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLA2G4A SUMF1 B3GNT5 GGT5 B4GALT6 B4GALT5 ASAH1 ASAH2 ABCB11 FUT2 FUT1 UGCG UGT8 ARSL ARSJ GGT1 ARSK VDR PSAP ARSH ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC CYP2C9 NDUFAB1 CYP2C8 CYP2U1 CYP4F2 CARM1 CYP1A2 RAB5A KPNB1 CYP4A11 CYP1A1 CYP1B1 CYP2C19 PIP4K2A NSDHL PIP4K2B LIPI PIP4K2C CYP2D6 LIPH FDXR SULT2A1 MED1 STARD3 BMX ACOT9 STARD4 STARD5 ACOT7 MED8 MECR STARD6 MED4 STARD7 MED6 MED7 RUFY1 CH25H PRKD3 FDX1 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 TIAM2 CYP2E1 FAR2 MTMR3 MTMR8 CGA BDH2 PLA2G3 BDH1 MTMR9 OXCT1 PLA2G5 OXCT2 PLA2G6 HMGCS2 MTMR6 HMGCLL1 MTMR7 AACS HSD11B1 ACAT1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA PTGES3 CYP4F3 NR1D1 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE CYP27B1 TSPO SPHK2 PTGR1 CYP24A1 PTGR2 CYP21A2 CYP2R1 AHRR SAMD8 PIP4P1 ECHS1 SGMS1 SGMS2 UBE2I PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIP5K1C PIAS4 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 INPP5D ABHD4 PIK3CG ABHD3 PIK3R6 INSIG2 PIK3R5 INSIG1 ARF1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 GBA1 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 CSNK2A1 PLA2G12A CERS5 GPX1 CSNK2A2 CERS6 GPX4 FAAH2 TNFRSF21 CERS1 CSNK2B CERS2 PPM1L HSD17B14 TPTE LRP2 CYP3A4 HSD17B11 MMAA MMUT AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 MBOAT1 DDHD2 MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PCCA PITPNB CPNE7 ECI1 PCCB CPNE6 GDE1 ACACB ACSM6 CPNE1 CPNE3 PTGDS MFSD2B ACAD11 SPHK1 ACAD10 MFSD2A SACM1L SLC51A ESRRA SLC51B PISD CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 CDK8 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 MTMR1 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 GPX2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS CBR1 SMARCD3 PCYT1B PCYT1A STARD3NL PLAAT1 PLAAT3 PLAAT2 CYP7B1 PLAAT5 PLAAT4 AKR1D1 GDPD1 ALOX12B GDPD3 GDPD5 HSD17B7 CYP7A1 ORMDL2 PPP1CC HSD17B1 TXNRD1 ORMDL3 HSD17B2 PIK3CB SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CYP8B1 ETNPPL PLEKHA8 PNPLA3 PTPN13 PNPLA6 VAPB ACAA2 INPPL1 MSMO1 CYP46A1 PLB1 ENPP6 PIK3CA PIK3R3 SBF1 HADH SBF2 PIK3C3 TPTE2 TRIB3 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 THEM4 CHAT PLD4 PLD6 ARNT2 PLD3 NFYA ALDH3B2 NFYB EBP NFYC CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 BMAL1 ACBD6 ACBD4 DGAT2L6 CRLS1 ACSF2 CYP11B2 PI4KA VAC14 PI4K2B PLD2 DEGS1 MTMR10 ALPI MTMR2 DEGS2 MTMR12 PI4KB PIK3C2A ACBD5 TNFAIP8 MTMR4 CYP4A22 MTM1 DBI INPP4A PCTP FIG4 ACOXL INPP4B ABCC3 PLA2G4F PIKFYVE INPP5F ABCC1 PI4K2A PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L ME1 CPT2 POMC MID1IP1 SLC25A20 PPP1CA CPT1B CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT PPP1CB CYP11B1 AKR1C3 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 LDLRAP1 CUBN APOA2 APOA1 PRKACG APOA5 PRKACA PRKACB ANGPTL4 SAR1B MBTPS1 ALB MBTPS2 PLA2G2A SLC27A1 HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ELOVL1 OLAH ELOVL4 ACSL1 ELOVL5 ELOVL2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 PRKAA2 PHYH ACOT8 PRKAG2 GNPAT ACOT2 ACOT4 PRKAB2 HACL1 DECR2 HAO2 EPHX2 PPARGC1A AMACR PPARGC1B RAN MAPKAPK2 CROT LBR ABCD1 OCRL BAAT MED16 SLC25A17 MED15 ACOX2 MED17 MED12 EHHADH MED14 MED13 AGPS ACOX3 MED10 TAFAZZIN HSD17B4 MED27 HMGCL MED26 MED23 MED25 MED24 MED20 PPARG CAV1 PPARA SRD5A3 PPARD NUDT7 VAPA CRAT SEC23A HEXB HEXA LTC4S RORA GLB1L3 GLB1L2 GLB1L SEC24B GLB1 SEC24A PLD1 ARSB HADHB HADHA ACADVL CYP17A1 SEC24D SEC24C EP300 MED30 MED31 RXRA INPP5E HDAC3 MOGAT3 MOGAT2 MOGAT1 GPS2 ABHD5 FABP12 RXRB GK3 GK2 LIPE AGMO GPAT2 TBL1X DGAT2 GK NCOA1 ABCA1 DGAT1 FABP9 FABP1 FABP2 FABP3 NR1H2 FABP4 FABP5 NR1H3 GPD2 NCOR2 FABP7 ARNT PNPLA4 PLIN3 NCOR1 PNPLA5 TBL1XR1 LPIN1 FABP6 LPIN2 MGLL SUMO2 LPIN3 PLIN1 PEX11A CD36 NCOA2 NCOA6 NCOA3 CCNC MVD PLIN2 ST6GALNAC5 ST6GALNAC6 PNPLA2 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 CREBBP SP1 NEU1 CHD9 ST8SIA5 ST3GAL5 ST3GAL2 ST3GAL3 CTSA TGS1 SREBF1 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility HBEGF EGF ERBB2 MEMO1 EGFR RHOA NRG1 DIAPH1 EREG NRG3 NRG4 NRG2 BTC REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764260 Regulation of Expression and Function of Type II Classical Cadherins JUP PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 SOX10 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 CDH19 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 SV2C SV2B SV2A VAMP1 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOR1 ADIPOR2 STK11 PRKAB2 PRKAA2 ADIPOQ MLXIPL PRKAG2 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression ASAH1 DICER1 TRPM1 PXN SMARCD1 SMARCD2 SMARCD3 SMARCE1 LIG1 GMPR SOX2 AKT2 ATP6V1E1 ATP6V1G1 ATP6V0B ATP6V0E1 DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H TBX2 HINT1 CCND1 ITGA2 SIN3A CDK2 CTNNB1 MET ATP6V1C1 GPR143 TNRC6C MOV10 TFAP2A AGO3 STT3B AGO4 CDH1 AGO1 AGO2 DPF1 TNRC6A TNRC6B DPF2 DPF3 SS18L1 ARID1A ARID1B PPARGC1A PLK1 SS18 SMARCB1 CCNB1 SOX10 SMARCC1 BRCA1 SMARCC2 ACTB ACTL6A GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME DATABASE ID RELEASE 95%75815 Ubiquitin-dependent degradation of Cyclin D PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CCND1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 GSK3B RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.4 rRNA processing in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 TRMT10C FASTKD2 PRORP MTERF4 ELAC2 TFB1M MRM1 HSD17B10 MRM2 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 95%448706 Interleukin-1 processing NFKB2 CTSG RELA IL18 IL1A CASP1 NFKB1 IL1B GSDMD PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis POLR2A POLR2B PIWIL2 POLR2C TDRKH POLR2D HSP90AA1 PIWIL1 POLR2E HENMT1 POLR2F ASZ1 POLR2G MAEL POLR2H MOV10L1 POLR2I POLR2J MYBL1 POLR2K TDRD9 POLR2L TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 PIWIL4 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%3371511 HSF1 activation HDAC6 HSBP1 PTGES3 EEF1A1 HSF1 YWHAE RPA3 HSP90AA1 VCP RPA1 HSP90AB1 RPA2 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair NEIL3 OGG1 NEIL1 NTHL1 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 CTNNB1 AXIN2 TCF7L2 TCF7L1 MYC LEF1 TCF7 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle FURIN CCR5 CXCR4 CCNT2 TAF4B NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 TBP NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 TAF9 NUP133 TAF1L NUP210 HMGA1 NMT1 NUP153 NUP93 NUP50 TAF15 TAF12 NUP35 NUP54 TAF13 TAF11 NUP37 NMT2 TAF8 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 LIG1 TAF1 CHMP4C RCC1 TAF10 CHMP4B VPS28 CHMP4A TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 GTF2A1 VPS4B CHMP2B GTF2A2 VPS4A GTF2B CHMP2A MVB12B GTF2E1 MVB12A GTF2E2 RANBP1 UBAP1 PDCD6IP NEDD4L CHMP3 CHMP6 XRCC6 CHMP7 XRCC4 XRCC5 LIG4 RANGAP1 TAF7L FEN1 ELOB XPO1 ELOC NUP214 RNMT CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ELL CCNT1 ERCC3 SUPT4H1 ERCC2 MNAT1 ELOA NELFB NELFCD UBB NELFA NELFE SUPT16H NCBP1 UBC NCBP2 ELOA2 SSRP1 CDK9 RPS27A TCEA1 PPIA TAF9B G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%416476 G alpha (q) signalling events KNG1 RASGRP2 RASGRP1 NPFFR2 OXTR NPFFR1 RGSL1 GRPR AVPR1B CYSLTR1 EDNRA EDNRB PROK2 PROK1 AVPR1A UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT NTSR1 NTSR2 ITPR1 GPR17 ITPR2 NMB ITPR3 XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN TRPC7 BRS3 GPRC6A GPR132 TRPC6 CCKAR GNRHR TRPC3 FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R MCHR1 P2RY10 P2RY11 LPAR1 GCGR LPAR2 GPR4 LPAR3 GCG LPAR5 MT-RNR2 F2RL1 F2RL2 CHRM3 F2RL3 CHRM1 GPR68 GPR65 CHRM5 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 TRIO MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 RGS17 PRKCQ PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 RGS16 ADRA1D P2RY6 HTR2A P2RY2 ADRA1B P2RY1 RGS21 ADRA1A CCK HRH1 HCRTR2 HCRTR1 KISS1 HBEGF MAPK7 KALRN GPR143 PTGFR PTGER1 TBXA2R AGT PRKCD PRKCA BTK GRK2 PRKCE GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 FFAR1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARHGEF25 EGFR HRAS PIK3R3 PIK3CA SOS1 PIK3R2 PIK3R1 NRAS MAPK1 MAPK3 MGLL DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ DAGLB DGKK DGKI DGKH AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 95%8948216 Collagen chain trimerization COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 COL19A1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL1A1 COL25A1 COL1A2 COL22A1 COL23A1 COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL20A1 COL4A6 COL6A3 COL21A1 COL9A1 COL8A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COL3A1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.3 Toll Like Receptor TLR1:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA YWHAZ EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 DCP2 MAPK11 PARN EXOSC7 KHSRP EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 95%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 95%3560796 Defective PAPSS2 causes SEMD-PA PAPSS2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190375 FGFR2c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 FGF20 FGF16 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 95%8935964 RUNX1 regulates expression of components of tight junctions OCLN RUNX1 TJP1 CBFB CLDN5 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 95%110314 Recognition of DNA damage by PCNA-containing replication complex PCNA UBA52 WDR48 RAD18 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2B POLE2 POLE3 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA ACSM6 ECHS1 ACSM3 ACADS HADH CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) STPG4 UHRF1 H2BC9 METTL23 H2AZ2 H4C9 DPPA3 H2BC8 H2BC5 H2BC3 H2BC1 AICDA H2AC20 TET3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KDM5B H2BC12 KDM5A H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 KDM6B H3C15 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation TNRC6C MOV10 AGO3 AGO4 CD274 AGO1 AGO2 TNRC6A TNRC6B RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G POLR3H POLR2K POLR3K POLR2L POLR1C POLR1D MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%6806942 MET Receptor Activation MET HGF SPINT1 HPN SPINT2 HGFAC PI3K CASCADE%REACTOME DATABASE ID RELEASE 95%109704 PI3K Cascade PIK3R4 PIK3R2 PIK3R1 FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%192814 vRNA Synthesis PARP1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 95%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum POFUT1 NOTCH2 NOTCH3 NOTCH1 POGLUT1 NOTCH4 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%109703 PKB-mediated events AKT2 PDE3B POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels GNG13 GNB2 KCNJ8 GNB1 KCNJ11 ABCC8 ABCC9 GNB4 GNB3 GNB5 GNGT1 GNGT2 KCNMA1 GNG3 GNG2 GNG5 GNG4 GNG7 KCNMB1 GNG8 KCNMB2 KCNMB3 KCNMB4 KCNK6 KCNK7 KCNK1 KCNN2 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNK18 KCNQ1 KCNQ2 KCNJ2 KCNQ3 KCNJ3 KCNQ4 KCNJ4 KCNQ5 KCNV1 KCNV2 GABBR2 KCNN1 KCNJ5 KCNN3 KCNN4 KCNJ6 KCNF1 GABBR1 KCNC1 KCNJ10 KCNK9 KCNC2 KCNJ12 KCNC3 KCNJ9 KCNC4 KCND1 KCND2 KCND3 KCNJ15 KCNAB1 KCNJ16 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 KCNK2 KCNK3 HCN2 KCNK4 HCN1 GNG10 GNG12 GNG11 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction SORBS3 MYL5 MYL7 ITGA1 PXN ITGB5 GUCY1B2 GUCY1B1 TPM4 TPM3 GUCY1A2 GUCY1A1 PDE5A ANXA2 TLN1 VCL TRIM72 DYSF PAK1 LMOD1 MYL6B MYL12B CACNA1H MYL6 MYL12A MYLK CACNA1G MYH11 CACNA1I MYL9 ALDH2 CALD1 PAK2 ANXA6 MYL10 CAV3 TPM2 MYL11 CALM1 TPM1 ANXA1 SORBS1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.8 Aerobic respiration and respiratory electron transport COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HIGD1C OXA1L KGD4 UCP1 NDUFAB1 ACAT1 MT-CO1 BCS1L COX19 COX17 ATP5MC1 SCO2 MT-CO2 MT-CO3 CYC1 CS VDAC1 ACO2 UBA52 HSCB HSPA9 TIMM21 UBB UBC RPS27A SLC25A12 FXN SLC25A13 NDUFB8 ATP5F1A SIRT3 ATP5F1B IDH3G CYCS MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 PC CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D LETM1 MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SLC25A4 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ATP5MK COX11 ATP5MJ COX14 NDUFV3 NDUFV2 ATP5MG NDUFV1 ATP5MF ATP5ME COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 COXFA4 NDUFA6 FAHD1 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 PDK4 NDUFS3 WDR26 PDHB GOT2 RMND5B LDHA MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 ECSIT PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 COX7B GPT COX7C COX8A COX8C DLD PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72163 pre-mRNA splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A IK SNRPN PRP4K WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111461 Cytochrome c-mediated apoptotic response XIAP CARD8 CYCS UACA MAPK1 AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 95%9938206 Developmental Lineage of Mammary Stem Cells FGF10 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation MAP2K4 IKBKB UBC RPS27A FBXW11 NFKB1 TNIP2 UBA52 BTRC CHUK SKP1 MAP2K1 MAP3K8 IKBKG CUL1 UBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 95%8985586 SLIT2:ROBO1 increases RHOA activity MYO9B SLIT2 ROBO1 RHOA DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins MUC13 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 MUC1 POMT2 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 POMT1 MUC4 MUC6 POMGNT1 MUC16 GALNT3 B4GAT1 MUC17 C1GALT1 MUC19 DAG1 SSPOP MUC5B LARGE1 MUC20 MUC21 LFNG NOTCH2 NOTCH3 NOTCH1 NOTCH4 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 SH3GL1 UBA52 STAM STAM2 MET HGS UBB SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME DATABASE ID RELEASE 95%5358493 Synthesis of diphthamide-EEF2 DPH7 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.4 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEL1L RAD23B PRKCSH UBA52 RNF185 GANAB PDIA3 VCP EDEM2 MOGS UBB DERL1 UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 UBXN1 PSMC1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 95%9735786 Nucleotide catabolism defects PNP PCP CE PATHWAY%REACTOME%R-HSA-4086400.4 PCP CE pathway CLTC CLTB FZD2 WNT5B FZD5 FZD7 WNT5A ROR1 FZD4 CLTA ROR2 AP2A1 PRICKLE1 FZD6 RAC2 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 RHOA AP2S1 SMURF2 SMURF1 AP2B1 PSMD8 PSMD6 PSMD7 PSMD2 ARRB2 PSMD3 SCRIB VANGL2 PSMD1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A DAAM1 PFN1 PARD6A ADRM1 PSMC5 PSMC6 RAC1 PRKCB SEM1 PSMC3 DVL1 PSMC4 DVL2 WNT4 PSMC1 DVL3 PSMC2 PRKCG WNT11 FZD3 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 95%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 RHOT2 ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B KIF5A NCKIPSD RAP1GDS1 KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 VHL AR CFTR RHOT1 BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 LRRC41 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 CCNE1 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 PLIN3 NCOA2 PTK2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification GGT5 GGT7 GGT6 DPEP2 GGT3P DPEP1 GGT1 ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CYP3A4 CYP1A2 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME%R-HSA-113501.5 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R3B E2F1 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B POLA2 PPP2R1A DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.2 Defective F8 cleavage by thrombin F8 F2 VWF INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 ISL1 GIP DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C GATA4 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.4 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 95%3215018 Processing and activation of SUMO SAE1 SENP5 SUMO3 SENP1 SUMO2 SENP2 UBE2I SUMO1 RWDD3 UBA2 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 95%4570464 SUMOylation of RNA binding proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HNRNPC BMI1 SUMO2 RING1 HNRNPK UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 NOP58 CBX2 PHC3 AAAS NUP160 NUP214 POM121C NUP42 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654719 SHC-mediated cascade:FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 KLB FGF16 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism MCCC2 ECHS1 ACAT1 MCCC1 PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH DLD SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A CSK RAF1 JAK2 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 95%381426 Regulation of IGF Activity by IGFBP PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 IGF2 CTSG IGF1 TF CALU KLK3 KLK2 SERPINA1 MBTPS1 KLK13 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN PLG ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 LAMB2 PDIA6 PAPPA MXRA8 SPARCL1 FN1 IGFALS LAMB1 SCG2 KLK1 LAMC1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 GZMH NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC F2 GAS6 APLP2 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 95%912694 Regulation of IFNA IFNB signaling IFNA2 IFNA8 TYK2 IFNA13 IFNA14 IFNA16 STAT2 IFNA17 SOCS3 PTPN6 IFNAR1 IFNA10 IFNA21 IFNB1 JAK1 IFNA5 IFNA4 PTPN1 SOCS1 IFNA7 USP18 IFNA6 PTPN11 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL PIK3CB RAPGEF1 CRK PIK3CD LYN PIK3R2 CBL PIK3R1 YES1 HCK BLNK SYK FYN PIK3R3 CRKL PIK3CA VAV1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 GNB1 GRP TCF7L2 GNB3 GCG PCSK1 GPR119 GNAT3 PAX6 DPP4 CTNNB1 CDX2 SPCS3 SPCS2 LEP SPCS1 FFAR4 FFAR1 SEC11A SEC11C CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 95%399956 CRMPs in Sema3A signaling DPYSL3 FES PLXNA2 PLXNA3 CDK5 FYN PLXNA4 NRP1 CDK5R1 CRMP1 GSK3B DPYSL4 PLXNA1 DPYSL5 SEMA3A DPYSL2 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 95%74751 Insulin receptor signalling cascade SOS1 SHC1 PIK3R4 PIK3R2 PIK3R1 INS NRAS FGF20 THEM4 MAPK1 FGF23 FGF22 KLB MAPK3 FLT3 IRS1 INSR PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 GRB10 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR SORCS3 NGFR NGF REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.8 Regulation of Complement cascade SERPING1 C3 CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC PROS1 F2 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163358 PKA-mediated phosphorylation of key metabolic factors PRKACG PFKFB1 PRKACA PRKACB MLXIPL ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells UPK1A EPCAM FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190374 FGFR1c and Klotho ligand binding and activation FGF23 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 95%6814848 Glycerophospholipid catabolism PNPLA7 PNPLA6 GDPD1 GDPD3 GDPD5 ENPP6 GDE1 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%9927354 ICOS co-stimulation PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3CA PIK3R3 PIK3R5 ICOSLG FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription CITED2 GCK FBXO32 G6PC1 CDKN1A INS HDAC1 NPY NFYA CCNG2 SIN3A NFYB NFYC BCL2L11 PLXNA4 FASLG PCK1 NR3C1 FOXO4 ATXN3 BTG1 DDIT3 TRIM63 STK11 SMAD2 SMAD4 AGRP SMAD3 BCL6 HDAC2 YWHAB TXNIP PINK1 AKT1 YWHAQ YWHAG RBL2 YWHAZ SFN PPARGC1A CAT ABCA6 RETN CDKN1B POMC SOD2 KLF4 CREBBP BBC3 FOXG1 KAT2B FOXO6 PCBP4 FOXO1 EP300 AKT2 IGFBP1 SIRT1 MSTN SIRT3 FOXO3 TXN SREBF1 GADD45A CAV1 AKT3 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 95%111458 Formation of apoptosome XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933947 Formation of the non-canonical BAF (ncBAF) complex BICRAL ACTL6A BICRA BRD9 SS18 SMARCD1 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SS18L1 ACTB TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP4C CHMP7 PIK3R4 CHMP4B CHMP4A BECN1 CHMP2B CHMP2A PIK3C3 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-HSA-888590.3 GABA synthesis, release, reuptake and degradation SNAP25 RAB3A SLC32A1 STX1A SYT1 SLC6A13 HSPA8 ABAT SLC6A1 VAMP2 CPLX1 GAD1 RIMS1 GAD2 ALDH5A1 DNAJC5 SLC6A11 SLC6A12 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 95%9605310 Defective Base Excision Repair Associated with MUTYH APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 95%75153 Apoptotic execution phase OCLN DSG1 DSG3 PLEC ADD1 ROCK1 H1-1 H1-0 H1-3 LMNB1 CTNNB1 TJP1 H1-2 H1-5 H1-4 VIM CLSPN CDH1 SATB1 CASP6 PRKCD APC KPNA1 BIRC2 SPTAN1 DFFB DFFA DBNL ACIN1 KPNB1 GAS2 MAPT BCAP31 GSN TJP2 FNTA DSG2 PKP1 BMX STK24 STK26 HMGB2 HMGB1 PRKCQ CASP8 PAK2 PTK2 CASP7 DNM1L DSP CASP3 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717319 brigatinib-resistant ALK mutants ALK DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 95%9675135 Diseases of DNA repair NEIL3 NEIL1 PMS2 MLH1 MSH2 MSH3 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 MSH6 RMI2 RFC3 RFC4 RMI1 OGG1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A NTHL1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-HSA-446652.9 Interleukin-1 family signaling RELA MAP3K7 IL1RL1 IL33 CTSG MAP2K6 IL1RL2 IL36A IL36B IL1R1 IL36G IL36RN IL1F10 SMAD3 TBK1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 GSDMD USP14 BTRC IL18 NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 PTPN13 HMGB1 CASP8 MAP2K1 UBE2N STAT3 NFKB1 MAPK8 CHUK PTPN11 IKBKB SQSTM1 MYD88 SIGIRR IRAK3 ALOX5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 CASP1 PSMD1 PSMA5 PSMA6 PSMA3 PTPN4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL18RAP IL1R2 PSMD13 IL4 NFKB2 TOLLIP PSMA7 PTPN20 PTPN23 PSMB6 IL18BP IL13 PSMB7 IL1RAPL1 PSMB4 MAP3K3 NKIRAS1 PTPN18 NKIRAS2 PSMB5 IL37 MAP3K8 IKBKG PTPN12 UBB PTPN14 IKBIP RIPK2 PSMB2 PTPN9 MAP2K4 PSMB3 PTPN7 IRAK4 PTPN5 UBC IL18R1 PSMB1 PTPN2 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 PTPN6 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.4 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis ANG DICER1 ELAC2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 95%426048 Arachidonate production from DAG ABHD6 ABHD12 DAGLB MGLL DAGLA MRNA EDITING: C TO U CONVERSION%REACTOME%R-HSA-72200.6 mRNA Editing: C to U Conversion APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR UNC93B1 TLR3 CTSS CNPY3 TLR8 TLR7 CTSB CTSV CTSL LGMN CTSK HSP90B1 TLR9 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 SKIC8 HBS1L EXOSC7 NT5C3B EXOSC6 SKIC2 SKIC3 DCPS EXOSC5 EXOSC4 DIS3 SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 95%8852405 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 95%5362768 Hh mutants are degraded by ERAD PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 VCP SHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA PARP1 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 RFC2 RFC1 PARP2 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 PARG APEX1 ADPRS PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 95%2160456 Phenylketonuria PAH NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 95%168276 NS1 Mediated Effects on Host Pathways NUP85 TPR KPNA7 NUP62 KPNA4 KPNA5 NUP88 GBP1 NUP43 KPNA3 RAE1 PABPN1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 EIF2AK2 ISG15 NUP37 KPNB1 MLKL KPNA2 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 95%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 GP1BA H2AC20 SETD1B SETD1A SIN3A ASH2L TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B NR4A3 MYL9 SIN3B DPY30 WDR5 GATA1 THBS1 RBBP5 PF4 H2AX KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KAT2B KMT2B H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 ZFPM1 PRKCQ H2BC11 KMT2A CBFB ITGA2B H3C15 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.3 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 95%5579015 Defective CYP26B1 causes RHFCA CYP26B1 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.3 Neutrophil degranulation AGPAT2 ARPC5 GM2A ACTR2 APEH ARSA FGR ASAH1 PECAM1 RAB9B PSAP MGST1 MME GLA P2RX1 CAT IST1 CD14 GSDMD RETN SPTAN1 DBNL FUCA2 KPNB1 GSN TICAM2 DNAJC3 PKP1 SDCBP RAC1 CST3 HMGB1 DSP DSG1 C3AR1 MAGT1 LTA4H NCSTN ADAM10 PSEN1 CDK13 GOLGA7 C5AR1 ACTR10 HSPA1B DDOST LPCAT1 ALOX5 CD59 CD55 HPSE SNAP25 RAB3A DNAJC5 KRT1 CNN2 TOLLIP ANXA2 MIF PPIA CSNK2B CTSB CDA FRMPD3 RAB14 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 RNASE2 UNC13D FLG2 PADI2 FPR1 CPNE1 GNS CPNE3 PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 VCP FUCA1 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 HMOX2 SIGLEC5 GHDC TMEM179B RAB3D HP EPX SLC44A2 PYCARD RAB44 CR1 GLIPR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B RAB5C STK10 BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 FCAR ALAD FCGR3B ORMDL3 PGM2 ACP3 TCIRG1 SNAP29 PGM1 RNASET2 DYNC1LI1 TNFRSF1B PKM PTGES2 TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC CTSD TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 FAF2 PTPRN2 SIGLEC14 ATP6V0C STK11IP SURF4 PRG2 NBEAL2 PRG3 RHOG DYNLL1 DERA BST2 RHOF BST1 NRAS VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ MAPK1 ACTR1B CTSH CD33 CTSC CD53 ATP6V1D MANBA ALDH3B1 FCER1G GAA NME2 ATP6V0A1 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CD47 DEGS1 CD44 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 CKAP4 OSTF1 CD93 LRRC7 CD300A IRAG2 ATAD3B OSCAR TYROBP DOCK2 DOK3 COPB1 ADGRG3 MOSPD2 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 NAPRT ADGRE3 HGSNAT DYNLT1 ATP6AP2 ARMC8 PLAUR MMP8 MMP9 CHI3L1 PDXK BIN2 CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 RAB27A CEACAM1 LAMP2 PPIE ARG1 AP2A2 A1BG SLC15A4 RAP1B RAP1A CTSG NPC2 PPBP PRSS3 PGLYRP1 PRSS2 CAMP SERPINA3 ORM1 FPR2 SLC11A1 SERPINA1 RNASE3 ORM2 TRPM2 BPI QSOX1 PRTN3 S100A9 CAP1 S100A8 AHSG LTF TLR2 S100A7 CD63 PTAFR DEFA1B ELANE DEFA4 LYZ CAPN1 LCN2 AMPD3 APRT PNP IMPDH1 IMPDH2 EEF1A1 ACLY HLA-H SLC27A2 HLA-B HLA-C HSP90AB1 ACAA1 ATG7 CAB39 B4GALT1 CTSS VAMP8 PSMD6 PSMD7 HUWE1 PSMD2 PSMD3 LAMTOR2 LAMTOR1 PSMD1 LAMTOR3 CYFIP1 IDH1 PRKCD PSMA5 SNAP23 PSMA2 PSMD12 PSMD11 STBD1 PSMD14 CEP290 PSMD13 KCNAB2 TUBB PSMB7 CYBB CYBA PSMB1 RAB7A HSPA8 MAPK14 UBR4 PSMC3 PSMC2 HSPA1A NCKAP1L APAF1 CFD C3 ATP8A1 VAPA ATP11B CCT2 ATP11A ROCK1 ATP8B4 B2M STING1 AP1M1 HEXB GLB1 ARHGAP45 IQGAP1 ANO6 PLD1 GUSB IQGAP2 ARSB HSP90AA1 FRK JUP ARHGAP9 STOM ITGAV FTH1 FTL NDUFC2 XRCC6 XRCC5 NFKB1 ITGAX CHRNB4 ITGAL DGAT1 FABP5 GPI CD36 HK3 PGAM1 LGALS3 CFP ALDOC ALDOA PFKL NEU1 PTPN6 CTSA S100A12 EEF2 MLEC TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization XIAP PML UBC PTEN RPS27A NEDD4 USP7 UBA52 UBB MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 95%8875513 MET interacts with TNS proteins MET TNS4 TNS3 HGF ITGB1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%1963642 PI3K events in ERBB2 signaling HBEGF EGF ERBB2 PIK3R1 EGFR NRG1 GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.4 Establishment of Sister Chromatid Cohesion PDS5B SMC1A SMC3 PDS5A WAPL STAG1 STAG2 ESCO1 RAD21 ESCO2 CDCA5 GLUCURONIDATION%REACTOME%R-HSA-156588.6 Glucuronidation UGT2B7 UGT1A3 SLC35D1 SLC35D2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT1A9 UGT2B17 UGDH UGT2B4 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CX3CR1 CCL3L3 CXCR5 CCR5 CXCR6 CXCR4 CCL7 CCR6 CCL5 CXCR3 PPBP CCL4 CCL3 CCL2 CCL1 CCL19 CCR2 CCL17 CCL16 CCR10 CCL25 CCR1 CCL22 CCL21 CCL20 CXCL10 CXCR1 CXCL11 CXCL12 CXCR2 ACKR4 ACKR3 ACKR2 XCR1 CCL28 CCL27 CXCL1 PF4 XCL2 XCL1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 95%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 95%977347 Serine metabolism SERINC4 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME%R-HSA-166020.4 Transfer of LPS from LBP carrier to CD14 LBP CD14 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.5 EPHA-mediated growth cone collapse LYN NGEF YES1 RHOA ROCK1 MYL12B FYN ROCK2 MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2S1 AP2A1 AP1G1 AP1S2 AP1S1 AP2A2 AP1S3 B2M AP1M2 AP2B1 AP1M1 AP1B1 HLA-A AP2M1 ARF1 CD8B PACS1 ATP6V1H LCK CD28 CD4 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 95%169893 Prolonged ERK activation events NTRK1 KIDINS220 RAPGEF1 CRK NGF YWHAB MAPK1 RAP1A FRS2 MAP2K1 MAP2K2 CRKL MAPK3 BRAF NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 95%194306 Neurophilin interactions with VEGF and VEGFR FLT1 NRP2 KDR NRP1 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%9725371 Nuclear events stimulated by ALK signaling in cancer PRF1 ICOS STAT5A IL10RA ZC3HC1 STAT3 CCNB1 HDAC1 NPM1 GZMB RB1 MAPK1 CEBPB MAPK3 DNMT1 FOXM1 TNRC6C MOV10 AGO3 AGO4 JUNB PTPN6 AGO1 AGO2 RPS6 IRF4 BCL2A1 SKP1 RBX1 TWIST1 ZAP70 CUL1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 95%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX4 ALOX12B ALOX15 ALOX12 GPX2 GPX1 ALOXE3 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-HSA-6807047.3 Cholesterol biosynthesis via desmosterol (Bloch pathway) CYP51A1 EBP LBR DHCR7 MSMO1 NSDHL HSD17B7 TM7SF2 SC5D DHCR24 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 DHDDS NUS1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules VASP ITK TRAC CD3G CD3E CD3D PLCG1 TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 EVL HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 NCK1 WAS PAK1 PAK3 LCK PLCG2 PAK2 ZAP70 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664422 FCGR3A-mediated phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 95%9709570 Impaired BRCA2 binding to RAD51 BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 RAD51 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound CACNA1D CABP1 LRRC52 ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) RPS6KA1 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 SGK1 MAPK1 NAB1 NAB2 LYL1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 PPP2CA EGR3 PPP2CB JUND EGR4 FOSL1 ID2 ID1 MEF2C CDK5 ID4 FOSB ID3 CDK5R2 TCF12 CHD4 MAPKAPK2 REST ATF1 PPP2R1B PPP2R1A SH3GL3 VGF EP300 JUNB MAPK14 MAPK11 MEF2D FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs NEDD4L STUB1 ITGB8 ITGB5 FURIN PMEPA1 CBL BAMBI STRAP UBA52 TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 PPP1CA USP15 ITGA8 PPP1R15A PPP1CB PPP1CC TGFB2 UBB TGFB3 UBC SMAD2 UCHL5 MTMR4 RPS27A SMAD4 SMAD3 SMURF2 SMAD7 SMURF1 NEDD8 TGFBR3 FKBP1A XPO1 LTBP4 ITGB3 ITGB1 LTBP3 LTBP1 ITGAV DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling NRG1 UBC RPS27A RNF41 ERBB2 USP8 AKT1 AKT2 UBA52 NRG2 UBB AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.4 Vasopressin-like receptors OXTR OXT AVPR1B AVP AVPR2 AVPR1A EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids CYP8B1 TBXAS1 CYP4F3 CYP4A22 CYP4B1 CYP4F8 CYP4F2 CYP4A11 PTGIS CYP4F12 CYP4F22 CYP4F11 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.5 TICAM1, RIP1-mediated IKK complex recruitment IKBKB RIPK1 UBC UBE2D1 TICAM1 RPS27A TLR3 UBE2V1 TRAF6 UBA52 BIRC2 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9953170 GBP-mediated host defense SFN FNTA GBP1 FURIN GBP5 PIM1 PGGT1B GBP2 FNTB GBP4 GBP3 CASP1 ACTG1 ACTB PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME%R-HSA-3656248.4 Defective HEXB causes GM2-gangliosidosis 2 HEXB NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%5250941 Negative epigenetic regulation of rRNA expression H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C SAP30L H2BC1 TAF1A HDAC1 H2AC20 SIN3A SUDS3 RRP8 SAP130 HDAC2 SAP30BP SIN3B BAZ2A SMARCA5 SUV39H1 CCNH TBP POLR2E POLR2F SAP18 POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 MBD2 GTF2H4 GTF2H5 ARID4B CDK7 TTF1 ERCC3 ERCC2 MNAT1 SAP30 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 UBTF H2BC13 H2BC14 SIRT1 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes PCBP4 TP53 CDKN1A ZNF385A RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951671 RUNX3 regulates YAP1-mediated transcription YAP1 TEAD3 TEAD4 CCN2 RUNX3 WWTR1 TEAD1 TEAD2 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME DATABASE ID RELEASE 95%6807004 Negative regulation of MET activity UBC PTPN2 SH3KBP1 RPS27A SH3GL3 EPS15 USP8 CBL SH3GL2 SH3GL1 UBA52 STAM PTPRJ LRIG1 STAM2 MET HGS HGF PTPN1 UBB NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 95%9706369 Negative regulation of FLT3 UBC RPS27A CBL UBA52 PTPRJ SLA ABL2 CSK SLA2 SOCS2 SOCS6 FLT3LG SH2B3 FLT3 UBB FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER CCNH RAD23A RAD23B PARP1 CETN2 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A DDB2 PIAS3 SUMO3 SUMO2 PARP2 USP45 UBE2I RPA1 PIAS1 RNF111 CHD1L SUMO1 RPA2 DDB1 UBE2V2 XPA XPC CUL4A RPA3 RBX1 ERCC4 ERCC1 UBE2N ERCC5 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RIPK1 TICAM2 TICAM1 RIPK3 CASP8 LY96 FADD CD14 TLR4 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 95%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 95%159234 Transport of Mature mRNAs Derived from Intronless Transcripts NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 SLBP CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 95%166166 MyD88-independent TLR4 cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046106 alpha-linolenic acid (ALA) metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 95%1227990 Signaling by ERBB2 in Cancer ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 PTPN12 NRG2 BTC TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 PTPN11 IKBKB PPP2CA PPP2CB MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140837 Intrinsic Pathway of Fibrin Clot Formation GP5 SERPINA5 GP9 SERPING1 A2M KLKB1 PRCP GP1BA KNG1 SERPINC1 C1QBP F9 PROC F10 SERPIND1 PROS1 F8 F2 VWF SERPINE2 GP1BB F12 F11 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions BAG4 FGFR1 ERLIN2 EPHRIN SIGNALING%REACTOME%R-HSA-3928664.4 Ephrin signaling EPHB6 EFNB2 NCK2 EFNB1 ARHGEF7 EFNB3 EPHB2 EPHB1 SDCBP EPHB4 EPHB3 PAK1 PAK3 RAC1 FYN MYL12A GIT1 PAK2 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%140534 Ligand-dependent caspase activation RIPK1 TICAM2 TRAF2 TNFRSF10B TICAM1 TNFSF10 TNFRSF10A LY96 FADD CD14 TRADD FAS FASLG CASP8 TLR4 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 95%1227986 Signaling by ERBB2 ERBIN PRKCA SOS1 PTK6 STUB1 HBEGF SHC1 HSP90AA1 ERBB2 EGF USP8 PIK3R1 EGFR MEMO1 CDC37 NRAS PLCG1 UBA52 MATK RHOA PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 SRC YES1 HRAS NRG1 FYN GAB1 PRKCE DIAPH1 GRB7 AKT1 EREG NRG3 PIK3CA NRG4 NRG2 BTC AKT3 PRKCD DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME%R-HSA-5619060.3 Defective CP causes aceruloplasminemia (ACERULOP) SLC40A1 CP GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN IL10 YES1 HCK SYK AHCYL1 FYN FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190373 FGFR1c ligand binding and activation FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.5 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167287 HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants ERBIN SOS1 HBEGF HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 NRG1 HRAS GAB1 EREG NRG3 PIK3CA NRG4 NRG2 BTC PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 95%75892 Platelet Adhesion to exposed collagen GP5 GP9 ITGA1 LYN GP1BA GP6 ITGA10 FYN ITGA2 ADAMTS13 FCER1G VWF ITGB1 GP1BB PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%77595 Processing of Intronless Pre-mRNAs PAPOLA SYMPK NCBP1 CSTF2T NCBP2 CLP1 FIP1L1 PABPN1 CPSF4 CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 PCF11 CPSF2 CSTF2 WDR33 CSTF1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%4090294 SUMOylation of intracellular receptors NR1H2 NR5A1 RXRA PIAS4 NR2C1 PIAS3 ESR1 SUMO3 SUMO2 UBE2I VDR PIAS1 HDAC4 NR4A2 SUMO1 NR3C2 THRB RORA RARA NR3C1 PGR PPARG AR PPARA DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p ALG11 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 95%73863 RNA Polymerase I Transcription Termination CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H POLR2K POLR2L GTF2H1 CAVIN1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 TTF1 ERCC3 ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932504 DAG1 core M2 glycosylations DAG1 POMT2 POMT1 POMGNT1 MGAT5B CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 95%5607763 CLEC7A (Dectin-1) induces NFAT activation NFATC2 AHCYL1 NFATC3 PPP3CA PPP3CB NFATC1 ITPR1 ITPR2 ITPR3 PPP3R1 CALM1 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 CYSLTR1 CYSLTR2 DPEP1 GGT1 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry PTK6 CDKN1A CDC25B CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 FZR1 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 95%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT4 WNT3A LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 SFRP2 WIF1 SOST TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand LBP CD36 LY96 TLR1 CD14 GSDMD GSDME S100A9 APOB TLR6 S100A8 TLR2 TLR7 FGB HMGB1 S100A1 FGA FGG TLR4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME%R-HSA-5654696.3 Downstream signaling of activated FGFR2 FGF18 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME%R-HSA-382556.6 ABC-family proteins mediated transport ABCB6 ABCB4 SEL1L KCNJ11 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 VCP ABCC2 ABCG8 ABCC6 EIF2S2 EIF2S1 EIF2S3 ABCG5 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 ABCA3 ABCC3 ABCC1 ABCG1 ABCD3 PSMD8 PSMD6 ABCC4 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 ABCD2 ABCA6 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 ABCC5 PEX3 UBC ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 SEM1 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 ABCA12 PEX19 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 95%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 95%4085023 Defective GFPT1 causes CMSTA1 GFPT1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME DATABASE ID RELEASE 95%9660826 Purinergic signaling in leishmaniasis infection C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME DATABASE ID RELEASE 95%2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 CILP PIK3CA TLR9 PIK3C3 TRIB3 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948001 CASP4 inflammasome assembly SERPINB1 CASP4 CALM3 CALM2 CALM1 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 95%9824856 Defective regulation of TLR7 by endogenous ligand TLR7 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.3 Electron transport from NADPH to Ferredoxin FDX1 FDX2 FDXR HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones KDM5D PHF8 UTY KDM4B H4C9 KDM2A KDM4D KDM2B ARID5B JMJD6 RIOX2 KDM7A KDM3A KDM1A KDM1B KDM4A KDM4C H3C8 KDM5B KDM5A KDM6A PHF2 KDM6B KDM5C KDM3B H3C15 PHOSPHORYLATION OF EMI1%REACTOME DATABASE ID RELEASE 95%176417 Phosphorylation of Emi1 FZR1 PLK1 FBXO5 CCNB1 CDC20 CDK1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013424 RHOV GTPase cycle CLTC IQGAP1 SH3RF1 VANGL1 ARHGEF7 PIK3R1 RHOV MAP3K11 SPTAN1 MYO9A TPM4 GIT1 TPM3 TXNL1 WASL ARHGAP12 CDC42 DEPDC1B ZNF512B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 PARD6B PAK6 PAK1 CCP110 CEP97 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9696264 RND3 GTPase cycle DSG1 VANGL1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 ROCK1 TMOD3 TXNL1 PKP4 DDX4 RASAL2 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B EPHA2 WDR6 DST UBXN11 DLG5 PICALM ARHGAP21 TNFAIP1 SEMA4F PTPN13 RND3 NISCH KTN1 CKB CKAP4 PLEKHG5 KCTD13 SCRIB VANGL2 FLOT2 DSP CAV1 CCDC88A TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis LPIN1 LPIN2 LPIN3 MOGAT3 MOGAT2 GPAM MOGAT1 GK3 GK2 AGMO GPAT2 DGAT2 GK DGAT1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 95%9665233 Resistance of ERBB2 KD mutants to trastuzumab ERBIN HSP90AA1 ERBB2 CDC37 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III CHMP3 CHMP6 CHMP7 TUBB8 IST1 TUBA8 TUBA1C LEMD2 TUBA1B TUBB8B TUBA1A TUBB2B TUBB2A SPAST CC2D1B TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D CHMP4C TUBA3C CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A TUBB4B TUBB4A SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME DATABASE ID RELEASE 95%9680350 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 CSF1R SHC1 LYN STAT3 CBL INPP5D PIK3R1 IL34 UBA52 GAB3 GRAP2 STAT1 KRAS UBB PTPN11 PIK3CB UBC RPS27A PIK3CD THOC5 SRC YES1 HCK FYN INPPL1 PLCG2 GAB2 PIK3CA CSF1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium ARL6 MCHR1 BBS2 BBS1 CCT2 CCT8 RAB3IP CCT5 BBIP1 BBS9 CCT4 BBS7 CCT3 TTC8 BBS5 BBS4 MKKS SMO TCP1 SSTR3 LZTFL1 BBS10 BBS12 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 95%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids ACSM6 HADHB MECR ACADL HADHA ACADVL ECHS1 ACADM ACSM3 ACADS HADH SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.4 Signaling by NOTCH1 HDAC1 NEURL1B DNER HES5 TLE4 APH1A TLE2 HDAC3 DLL4 MIB2 ITCH PSENEN TLE1 DTX1 NCSTN MIB1 DTX2 APH1B HEYL PSEN2 DLK1 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 DTX4 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 ARRB1 RBX1 ARRB2 HIF1A HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 NUMB HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NBEA NOTCH1 CUL1 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 95%9665246 Resistance of ERBB2 KD mutants to neratinib ERBIN HSP90AA1 ERBB2 CDC37 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%6787639 GDP-fucose biosynthesis GMDS SLC35C1 FPGT FCSK GFUS FUOM MYD88 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 95%5602680 MyD88 deficiency (TLR5) MYD88 TLR5 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism NT5E NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190322 FGFR4 ligand binding and activation FGF19 FGF18 FGFR4 FGF1 FGF2 FGF23 FGF4 FGF6 FGF9 KLB FGF20 FGF16 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 95%9675143 Diseases of the neuronal system RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling NRG1 HRAS SOS1 HBEGF SHC1 NRAS NRG3 EREG NRG4 BTC NRG2 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358752 CTNNB1 T41 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest PCBP4 CDKN1A CDKN1B ARID3A E2F1 CDK2 E2F7 E2F8 CCNA2 TP53 CCNA1 CCNE2 CCNE1 ZNF385A CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 95%5607764 CLEC7A (Dectin-1) signaling RELA NFATC1 MAP3K7 NFKB1 UBA3 UBE2M CDC34 NFATC2 CHUK IKBKB CARD11 MALT1 ITPR1 RELB ITPR2 CLEC7A ITPR3 CARD9 NFKBIA MAP3K14 TAB1 UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PLCG2 PSMD3 PSMD1 CALM1 PYCARD PRKCD PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 TRAF6 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 NFKB2 PSMB6 PSMB7 IL1B PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB TAB3 SKP1 PDPK1 TAB2 CASP8 PPP3R1 UBE2N CUL1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-HSA-173599.4 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UXS1 UGDH UGP2 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112040 G-protein mediated events GNAQ ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 GNAT3 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 CAMK2A GNAI3 GNAI1 GNAI2 CALM1 CAMK2G PRKCD PRKCA PLCB4 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 NBEA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle ERBIN ARHGAP26 ARHGEF3 VANGL1 ARHGEF1 ARHGAP32 ARHGEF2 PIK3R2 ARHGEF5 PIK3R1 RHOB ROCK1 CAVIN1 ROCK2 MYO9A ABR RTKN ECT2 ARHGEF28 MCF2 NET1 RHPN2 ARHGDIG SOWAHC STARD8 CIT ARHGEF25 PKN3 TFRC IQGAP3 SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 STOM MCF2L RACGAP1 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9033807.2 ABO blood group biosynthesis FUT2 FUT1 ABO NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAPK1 RAF1 MAP2K1 MAP2K2 MAPK3 BRAF DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 95%3359471 Defective MMAB causes MMA, cblB type MMAB SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors SCARF1 APOB CALR HSP90AA1 HSPH1 HYOU1 BACTERIAL INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824439 Bacterial Infection Pathways HBEGF GBP1 FURIN HSP90AB1 HBB ATP6V1H MAPK1 STAM2 CTSG CTNNB1 MET RNF213 MAPK3 STX1A B2M CDH1 MRC1 SRC GBP2 UBE2D2 GBP6 GBP4 HBA2 STX1B NOS2 CBLL1 LTF TLR2 GUCY2C SYT2 NHERF4 GSK3A CALM1 ENO1 SNAP25 SH3KBP1 TRIM27 HSP90AA1 KPNA1 SYT1 CD9 CBL CTNND1 UBA52 STAM DUSP16 VPS33B CORO1A PGK1 HGS RAB5A KPNB1 SV2C SV2B SV2A VAMP1 UBB TXNRD1 MAP2K4 UBC RAB7A RPS27A SH3GL3 UPK1A EPCAM EPS15 SH3GL2 SH3GL1 SFPQ VAMP2 MAP2K7 EEF2 CASP4 MAP2K1 MAP2K2 CALM3 CALM2 PDCD6IP MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST6GALNAC2 ST3GAL4 ST6GALNAC3 ST6GALNAC4 GALNT1 ST3GAL1 ST3GAL2 ST3GAL3 ST6GAL1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain CHM RABGGTB RABGGTA NDRG1 BCL6 PERP TP53I3 BIRC5 TP63 TP73 PPP1R13B TP53 TP53BP2 BCL2L14 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 95%3359467 Defective MTRR causes HMAE MTR MTRR SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.8 Synthesis of PIPs at the ER membrane PI4K2B MTMR2 SACM1L SBF1 PI4KA UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 95%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K7 FURIN MAP2K1 MAP2K2 CALM1 PDCD6IP CELL CYCLE%REACTOME DATABASE ID RELEASE 95%1640170 Cell Cycle PCNA NPM1 YWHAE EML4 YWHAQ CDCA5 MYBL2 NCAPG YWHAG ARPP19 ZNF385A NCAPH YWHAH DHFR ENSA TK1 SIRT2 USO1 CDKN2D CDKN2C NCAPD2 CDC14A TUBB8 RAB2A IST1 DYRK1A VRK1 AURKA LEMD2 TUBB8B RRM2 NUMA1 FIRRM ESPL1 RAB1A RAB1B CABLES1 FBXO5 ESCO1 ESCO2 KPNB1 BLZF1 SPAST CC2D1B TOP2A CNEP1R1 TYMS PTTG1 CKS1B MASTL GORASP2 GORASP1 PPP2R2D CHMP4C POLE RFC1 CHMP4B CHMP4A UBE2V2 PRKCB CHMP2B CHMP2A POLE4 POLE2 POLE3 UBE2N CHMP3 CHMP6 CHMP7 PLK3 CDC7 HSPA2 FBXL18 FBXL7 PHF20 FEN1 MCM10 DBF4 UBE2I SUMO1 RPA4 CCP110 RBX1 AJUBA CCNH PIAS4 POLR2A POLR2B POLR2C POLR2D BRCC3 LYN POLR2E POLR2F POLR2G POLR2H CDKN2B POLR2I POLR2J POLR2K POLR2L BABAM1 CDK7 BABAM2 MNAT1 UIMC1 TUBB6 TUBB3 TUBB1 CSNK2A1 CSNK2A2 TUBA4B TUBA4A CSNK2B TP53 RUVBL1 ABL1 WRAP53 TUBA8 TUBA1C TUBA1B CDC25A TUBA1A TUBB2B TUBB2A LIN54 LIN37 LIN9 PKMYT1 FOXM1 TUBAL3 WEE1 LIN52 TUBA3E CLSPN NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 MDM2 MDM4 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 RBBP4 NUP54 ABRAXAS1 NUP37 ERCC6L RBBP7 ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 AKT2 CDCA8 PMF1 SKA1 SKA2 CHEK2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 TPX2 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MLH1 MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 RBL2 ANAPC15 CENPS RBL1 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 JAK2 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 PPP1CB CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 HJURP RFC5 RMI2 PPP2R2A RFC3 PPME1 GTSE1 RFC4 RMI1 BORA TERT FKBPL RFC2 FBXW11 OPTN TOP3A OBI1 HMMR RPA1 HUS1 MIS18BP1 RAB8A RPA2 PPP1R12A LCMT1 SEM1 PPP2R3B RAD50 TICRR MCM7 RAD51 MCM8 RAD51C GMNN RPA3 RAD17 SKP1 RAD1 CCNA2 ATM CCNA1 MCM3 DNA2 RAD9B MCM4 RHNO1 MCM5 MCM6 ATR RAD9A MCM2 CLIP1 CUL1 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 FKBP6 PRKACA BTRC GOLGA2 PRIM2 PRIM1 POLA1 POLA2 PRKAR2B HERC2 PTK6 CDKN1A HDAC1 CDKN2A HSP90AB1 CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 MDC1 MYC YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 TNPO1 NUP214 PRKCA SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 PSMB6 TUBB CEP131 PSMB7 HAUS4 HAUS3 PSMB4 CSNK1D HAUS6 PSMB5 HAUS5 CSNK1E LEMD3 TUBG2 UBB PSMB2 TUBG1 PSMB3 HAUS2 HAUS1 MZT2B UBC MZT2A PSMB1 NME7 RPS27A AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 ADRM1 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 PSMC5 HAUS7 CEP70 PSMC6 CEP72 PSMC3 PSMC4 CEP192 PSMC1 PCNT CEP76 PSMC2 CEP78 PLK4 CDK11A ODF2 CCNB2 NEK9 CEP152 NEK6 CDK11B MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 LMNB1 PIF1 FIGNL1 GAR1 CTC1 KMT5A TEX12 TEX15 RNF168 NSD2 CENPW CENPX RUVBL2 OIP5 MSH4 MSH5 HSP90AA1 NHP2 ANKRD28 NOP10 SYCP2 CDC25C SYCP1 CDKN1C SYNE2 RB1 SYNE1 CDKN1B PPP6C PPP6R3 CCND3 SMC1B FZR1 MND1 CCND2 E2F1 REC8 E2F2 SYCP3 E2F3 RTEL1 SKP2 CHTF8 DAXX TP53BP1 ATRX STAG3 CDK6 RSF1 TFDP1 DMC1 PSMC3IP CCNE2 TFDP2 MLH3 CDK4 MIS18A NEK11 CCNE1 H2AX PRDM9 DSCC1 SHQ1 CPAP LIG1 DKC1 MAX H2AB1 SYCE3 H2AC19 SYCE2 POLD3 COP1 H2BC26 POLD4 H2AC14 SYCE1 POLD1 H2BC12L SPO11 POLD2 RCC1 CHTF18 H2BC21 SUN2 EP300 SUN1 RNF8 H3-3B STN1 H3C8 TEN1 H2AC8 H2AC6 KIF23 H2AC7 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 STAG1 H2BC15 NIPBL STAG2 H2BC11 RAD21 KIF20A H3C15 ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 LPIN1 LPIN2 LPIN3 E2F4 E2F5 E2F6 SMARCA5 GSK3B CSNK1A1 PHLDA1 PCBP4 AKT3 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 95%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP ZNF141 HDAC1 ZNF382 H2AC20 ZNF547 ZNF418 ZNF224 MBD3 ZNF354A ZNF136 ZNF649 GATAD2B GATAD2A CHD3 SUMO2 UBE2I ZNF778 HDAC2 ZNF454 ZNF28 CBX5 CHD4 ZNF273 SETDB1 ZNF816 ZNF519 ZNF610 ZNF264 ZNF680 TRIM28 MTA2 ZNF30 ZNF257 RBBP4 MTA1 ZNF33A MTA3 RBBP7 ZNF331 H2AX ZNF93 H2AB1 H2AC19 H2BC26 ZNF708 H2AC14 H2BC12L H2BC21 ZNF324 ZNF534 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ZNF320 H2BC17 H2BC12 H2BC13 ZNF669 ZNF765 H2BC14 H2AJ H2BC15 ZNF317 H2BC11 ZNF425 H3C15 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 95%3296482 Defects in vitamin and cofactor metabolism TCN2 CD320 MCCC2 BTD ACACA PC PCCA HLCS CUBN CBLIF MMAB MCCC1 AMN PCCB MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 PABPN1 EIF4E PAIP1 EIF4B EIF4A3 PABPC1 DIS3L2 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH PECR SLC25A17 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%426117 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A6 SLC12A3 SLC12A1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 95%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 SNU13 DCAF13 NOP14 UTP6 UTP4 KRR1 UTP3 PNO1 RCL1 TBL3 MPHOSPH10 NOL11 NOP2 TRMT112 NOP56 NOP58 GAR1 NHP2 NOP10 RPS14 DKC1 RPS2 RPS9 RPS7 RPS6 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 95%977225 Amyloid fiber formation H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FURIN H2BC1 INS H2AC20 APH1A PSENEN APOA1 NCSTN APOA4 APH1B HSPG2 ADAM10 APOE NPPA SIAH1 PRL CALB1 NAT8B BACE1 APCS TSPAN33 B2M GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI LTF ITM2B UBA52 SIAH2 LYZ FGA CALCA H2AX UBB GSN SEMG1 H2AB1 UBC H2AC19 IAPP H2BC26 H2AC14 RPS27A H2BC12L H2BC21 PRKN TTR H3-3B H3C8 H2AC8 MFGE8 H2AC6 H2AC7 TSPAN14 H2BC17 APP H2BC12 H2BC13 H2BC14 CST3 SAA1 H2BC15 USP9X H2BC11 UBE2L6 H3C15 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKX PRKACG PRKACA PRKACB NBEA CALM1 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 95%983705 B Cell Activation RELA MAP3K7 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 CARD11 IGKV2D-28 MALT1 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 TRPC1 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK IGLC1 BTRC IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PRKCB HRAS PPP3CA PPP3CB PPP3R1 VAV1 SOS1 NFATC1 PIK3R1 NFKB1 NRAS NFATC2 CHUK CD19 IKBKB FKBP1A PSMD8 PSMD6 PSMD7 DAPP1 RASGRP3 PSMD2 REL NFKBIE PSMD3 CD22 PIK3AP1 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD FBXW11 PTPN6 ADRM1 PPIA PSMC5 SYK PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 95%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.7 TRAF6 mediated IRF7 activation IFNA2 IFNA8 TRAF2 IFNA13 IFNA14 IFNA16 IFNA17 TRAF6 IFNA10 IFNA21 IFNB1 IFIH1 TRIM4 CREBBP TBK1 EP300 IRF3 MAVS RNF135 RIGI TRIM25 IKBKE IRF7 IFNA5 TANK SIKE1 IFNA4 IFNA7 IFNA6 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME%R-HSA-5609974.5 Defective PGM1 causes CDG1t PGM1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME%R-HSA-5627083.4 RHO GTPases regulate CFTR trafficking CFTR GOPC RHOQ SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 95%5339716 Signaling by GSK3beta mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.4 Mineralocorticoid biosynthesis HSD3B2 HSD3B1 CGA LHB CYP21A2 CYP11B2 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 95%5387390 Hh mutants abrogate ligand secretion PSMA5 PSMA6 SEL1L PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 HHAT VCP IHH SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DERL2 PSMB1 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 SYVN1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 95%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 DTX4 TBK1 NFKB1 IRF3 NFKBIA NLRP4 DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%451927 Interleukin-2 family signaling IL21R LGALS9 SOS1 HAVCR2 IL15RA PTK2B STAT5A STAT5B IL15 SHC1 IL5 STAT3 IL3RA PIK3R2 INPP5D IL2RB SOS2 PIK3R1 IL9 GRB2 IL9R JAK3 STAT4 JAK2 JAK1 IL2RG STAT1 CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 SYK LCK INPPL1 GAB2 PIK3R3 PIK3CA IL21 IL2RA IL5RA CSF2RB CSF2RA METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 95%6806667 Metabolism of fat-soluble vitamins VKORC1L1 UBIAD1 LRP1 RETSAT APOA2 APOM APOA1 TTPA BCO2 APOA4 BCO1 HSPG2 VKORC1 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 95%1606341 IRF3 mediated activation of type 1 IFN ZBP1 DTX4 TBK1 IRF3 NLRP4 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation LCK AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 ARF1 CD4 ATP6V1H ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants ALK SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 95%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 95%9609736 Assembly and cell surface presentation of NMDA receptors GRIN3A APBA1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D KIF17 GRIN1 DLG1 GRIN2A CASK LIN7A DLG2 LIN7C NBEA DLG3 LRRC7 LIN7B DLG4 NEFL CAMK2G GRIN3B DNA METHYLATION%REACTOME DATABASE ID RELEASE 95%5334118 DNA methylation UHRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 DNMT3L H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD PPM1K BCKDHA BCKDHB DBT DLD DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-9675136.4 Diseases of DNA Double-Strand Break Repair BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022923 DS-GAG biosynthesis NCAN CHST15 CSPG4 BGN DCN BCAN VCAN DSEL CHST14 DSE UST CSPG5 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME DATABASE ID RELEASE 95%9025106 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.4 DNA Double Strand Break Response HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 KPNA2 H2BC15 TP53 H2BC11 ATM UBE2N PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CDK2 CCNE2 RB1 CCNE1 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8941332 RUNX2 regulates genes involved in cell migration ITGA5 ITGBL1 MMP13 AKT1 AKT2 CBFB AKT3 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry AGRN FURIN NCL EGFR GPC1 LY96 GPC3 GPC2 CD14 GPC5 RAB5B GPC4 RAB5C GPC6 CX3CR1 HSPG2 IGF1R SDC1 RAB5A SDC4 SDC2 SDC3 TLR4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis MED19 MED18 SREBF2 MED11 WNT1 RELA MED9 MED29 MED28 MED22 TGFB1 MED21 CDK19 MBD3 MED13L ANGPTL4 LPL GATAD2B GATAD2A CDK8 SMAD1 SMAD4 LEP CHD4 CIDEA SMARCD3 CCND3 MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MTA3 CARM1 EBF2 RBBP7 BMP7 CDK4 KLF4 EP300 MED1 MED30 MED31 MED8 MED4 MED6 MED7 ELOVL3 CEBPA HNRNPU RXRA NFKB1 HDAC1 KLF5 HDAC3 CEBPB TBL1X PCK1 NCOA1 EGR2 FABP4 NCOR2 COX7A1 CHD3 NCOR1 TBL1XR1 PLIN1 HDAC2 THRAP3 FAM120B PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC ADIPOQ HELZ2 MED16 MED15 CREBBP MED17 CHD9 MED12 MED14 MED13 TNF MED10 EBF1 WNT10B NR2F2 ADIRF SLC2A4 ZNF638 TGS1 CEBPD ZNF467 MED27 MED26 MED23 MED25 MED24 MED20 PPARG PPARA DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%186763 Downstream signal transduction SOS1 CRK STAT5A STAT5B STAT3 PIK3R2 PIK3R1 PDGFB NRAS PLCG1 STAT1 PTPN11 PIK3CB RAPGEF1 NCK2 NCK1 RASA1 SRC PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 95%8939211 ESR-mediated signaling JUN GNG13 ZNF217 FKBP5 EBAG9 GNB2 KDM4B YY1 GNB1 GNB4 DDX5 GNB3 GNB5 GNGT1 GPAM GNGT2 SPHK1 GNG3 CXCL12 ESR1 GNG2 GNG5 GNG4 GNG7 GNG8 POU2F1 NOS3 TBP HSP90AA1 EGF EGFR CDKN1B S1PR3 CARM1 H2AX H2AB1 H2AC19 MMP2 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 MED1 H2AC8 PRKCZ H2AC6 CTSD H2AC7 HRAS H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 MMP3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 PIK3R3 PIK3CA CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 HBEGF H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 HDAC1 NRAS H2AC20 HSP90AB1 KDM1A MAPK1 GNAT3 CCND1 PTGES3 NRIP1 FKBP4 NCOA1 SRF MAPK3 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 ESR2 AGO2 SRC TNRC6A TNRC6B GNAI3 XPO1 GNAI1 GNAI2 AKT1 CALM1 AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 MMP9 KANK1 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG KAT2B FOXA1 ZDHHC7 TLE3 KPNA2 PPID TGFA USF1 CAV2 FOS FOXO3 GREB1 ELK1 IGF1R GNG10 CHD1 PTK2 MMP7 EREG PGR TFF3 UHMK1 TFF1 BTC ZDHHC21 CAV1 GNG12 CXXC5 EPGN AKT3 GNG11 USF2 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.4 Histamine receptors HRH3 HRH2 HRH4 HRH1 METAL ION SLC TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425410 Metal ion SLC transporters SLC24A2 SLC24A3 SLC41A2 SLC41A1 SLC30A10 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 CP SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC31A1 SLC40A1 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC8A1 SLC8B1 SLC24A1 SLC8A2 HEPH SLC24A4 SLC11A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SRI SLC9A8 SLC9A9 SLC9A1 SLC24A5 SLC39A4 SLC8A3 SLC11A2 CALM1 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias KCNJ11 ABCC8 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 95%68952 DNA replication initiation POLE4 POLE POLE2 PRIM2 POLE3 PRIM1 POLA1 POLA2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome ARSB TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.3 Translesion synthesis by REV1 RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.5 RNA Polymerase I Transcription H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 CAVIN1 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.6 Synaptic adhesion-like molecules LRFN1 PTPRS PTPRF GRIA1 GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG3 RTN3 DLG4 FLOT1 LRFN3 FLOT2 PTPRD GRIA3 LRFN2 GRIA4 LRFN4 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA PLA2G2D MIGA1 PLD1 PLA2G2E DDHD2 AGPAT2 PLA2G5 DDHD1 PLA2R1 PLA2G10 GPD1 GPD1L PLD6 GPAM PLA2G2A GPAT2 LPCAT1 PLA2G4A PLD2 ALPI GPD2 GNPAT LIPI ACP6 LIPH PLA2G12A PLA2G4D GPAT4 PLA2G4B GPAT3 AGPAT5 PLA2G1B LPCAT4 AGPAT1 AGPAT3 AGPAT4 LCLAT1 PLA2G2F MIGA2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME%R-HSA-433692.6 Proton-coupled monocarboxylate transport SLC16A7 SLC16A8 EMB SLC16A3 BSG SLC16A1 LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 95%2046105 Linoleic acid (LA) metabolism ACSL1 FADS1 ELOVL5 ELOVL2 ABCD1 ELOVL3 ELOVL1 FADS2 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9022692 Regulation of MECP2 expression and activity HTT HDAC1 HDAC3 GPS2 SIN3A LBR HIPK2 PRKACA TBL1X AURKB FOXG1 NCOR2 TNRC6C MOV10 NCOR1 AGO3 TBL1XR1 AGO4 CAMK2B AGO1 CAMK2D AGO2 HDAC2 TNRC6A TNRC6B CAMK2A CAMK4 CALM1 CAMK2G SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections IFNA2 IFNA8 RELA IFNA13 IFNA14 IFNA16 SAP30L IFNA17 NPM1 ITCH IFNA10 IFNA21 IFNB1 ISG15 NR3C1 PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP YWHAE VPS41 NPIPB3 VPS45 NMI PARP10 PARP6 SFTPD CHD4 IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 MTA2 VPS33B RIPK3 REST KPNB1 FNTA CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A VAV1 UBE2N CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 PTGES3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 FKBP4 OST4 EDEM2 MOGS SDC4 ZDHHC11 IFNGR1 DDOST SDC2 IFNGR2 MGAT4C SDC3 ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 SUMO1 GPC5 GPC4 GPC6 KEAP1 RBX1 TRIM25 SDC1 VHL ISCU BTK IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TLR8 KPNA2 MAP3K7 VCP NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA MAVS TAB1 GJA1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C PYCARD NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 TRAF3 RANBP2 TRAF6 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 BECN1 NUP50 NUP35 RBBP4 NUP54 NUP37 NOD1 RBBP7 NOD2 NCK1 AKT2 PDPK1 RPS27 ITGB1 TLR9 PIK3C3 SOS1 SNRPD2 SNRPD1 SNRPD3 PIK3R4 BST2 PRMT1 CHUK TJP1 PCBP2 PTPN11 CASP1 JAK2 ZCRB1 SYK SNRPG SNRPE PPIH PPIG SNRPF AP2A1 SNRPB AP2A2 DDX5 AP2M1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 SAR1B IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 AP2B1 IGKV2D-30 IGHV4-59 TLR1 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 TLR2 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 SAP18 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 IGLC2 S1PR1 JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 IGLV3-19 MTA3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 RPS4Y1 IGLV3-1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 RPS17 IGKC RPS15A IGKV1-39 IGLV3-21 RPS16 RPS19 IGKV1-33 BRD4 RPS18 RPS3 CRBN RPS2 IGLC7 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 RPS13 IGLC6 RPS12 IGKV1-5 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 PDCD1 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 HLA-H HLA-B HLA-C ATG14 HDAC1 HLA-F HSP90AB1 HLA-G HLA-E YWHAB FKBP1A IKBKE AKT1 IRF7 NUP214 SFN YWHAZ UBA52 TUBB UBB UBC RPS27A UBE2V1 PSMC6 CAV1 FURIN ATP1B3 ROCK1 ATP1B2 ROCK2 ATP1B1 CUL3 MBD3 STAT1 GATAD2B GATAD2A ZBP1 SEC23A TBK1 B2M IRF3 STING1 HLA-A FXYD4 FXYD3 FXYD2 FXYD1 PALS1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 UVRAG ANO5 MAP1LC3B ANO2 ANO3 HSP90AA1 ANO1 RB1 ATP1A4 ATP1A3 ATP1A2 FNTB SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 EP300 IL6R RUNX1 NRP1 MASP1 NFKB1 SRPK1 KDM1A HSPG2 ITGA4 AGRN CHD3 HDAC2 ST6GALNAC2 SIKE1 GSK3B CSNK1A1 ST6GAL1 ST6GALNAC3 ST6GALNAC4 ARID4B SAP30 CREBBP SP1 ST3GAL4 NFE2L2 BCL2L1 ST3GAL1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 TAB3 TAB2 CTSL IFNA5 IFNA4 IFNA7 IFNA6 AKT3 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib ERBIN HSP90AA1 ERBB2 CDC37 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 95%3249367 STAT6-mediated induction of chemokines STAT6 TBK1 STING1 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.4 MPS IV - Morquio syndrome A GALNS BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MATURATION OF DENV PROTEINS%REACTOME%R-HSA-9918432.1 Maturation of DENV proteins KPNA7 KPNA4 KPNA5 KPNA3 RPN2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 SPCS2 PRKG2 SPCS1 OST4 SEC11A SEC11C DDOST TMEM258 DAD1 OSTC CANX CALR ACOT2 STT3A STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 KPNA1 IPO7 DNAJB11 P4HA1 UBA52 P4HA2 P4HA3 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UBB UBC DNAJC3 RPS27A KPNA2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME%R-HSA-428890.4 Role of ABL in ROBO-SLIT signaling CAP1 ABL2 CLASP1 CLASP2 SLIT2 ABL1 ROBO1 CAP2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 95%9824585 Regulation of MITF-M-dependent genes involved in pigmentation SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 LEF1 SOX10 SMARCC1 CTNNB1 SMARCC2 GPR143 ACTB SMARCE1 ACTL6A SYTL2 PMEL TFAP2A MYO5A RAB27A TYR AKT2 MYRIP MAPK14 DPF1 BCL7A DPF2 DCT BCL7C IRF4 BCL7B DPF3 SMARCA2 SMARCA4 TYRP1 MLANA USF1 MLPH SS18L1 ARID1A ARID1B ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.3 Activation of AMPK downstream of NMDARs PRKAG3 CAMKK2 PRKAB2 PRKAA1 PRKAA2 CALM1 PRKAG1 PRKAB1 PRKAG2 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2408522 Selenoamino acid metabolism HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 TXNRD1 RPS17 SARS1 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A PAPSS2 RPL6 PAPSS1 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 EPRS1 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 95%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes UBE2A UBE2C UBE2L3 UBE2E1 UBE2D1 UBE2W USP7 USP5 UBE2S UBA52 UBA1 UBE2K UBE2Z CDC34 UBE2Q2 UBE2E3 UBB UBE2R2 UBC UCHL3 RPS27A UBE2T OTULIN UBA6 UBE2D2 USP9X UBE2H UBE2G1 UBE2G2 UBE2B PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.8 Phase I - Functionalization of compounds CYB5B CYP51A1 CYP4B1 CYB5R3 CES3 CYP27A1 CYP39A1 CYP3A5 AOC1 CYP2A13 CES1 FMO3 CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP7A1 CYP1B1 CYP2C19 CYP2D6 CMBL ALDH3A1 FDXR POR CES2 MAOB MTARC2 MAOA CYP8B1 MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP46A1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 RXRA ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 ARNT2 PTGES3 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR CYP4F12 PTGIS PTGS1 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP4F11 AIP CYP11B1 TBXAS1 ADH1C ADH1A ADH4 PAOX ALDH1A1 ALDH2 CYP3A4 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656535 TGFBR1 LBD Mutants in Cancer FKBP1A TGFBR2 TGFB1 TGFBR1 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) GP5 SOS1 GP9 CRK SHC1 MPL FN1 GP1BA THPO RASGRP2 RASGRP1 RAP1B RAP1A CSK ADRA2C FGB ADRA2B RAPGEF3 FGA ADRA2A RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 F2 AKT1 PTK2 ITGB3 ITGA2B GP1BB SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R HRAS SOS1 IGF2 IGF1 IGF1R NRAS GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 95%157858 Gap junction trafficking and regulation CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 TJP1 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME DATABASE ID RELEASE 95%162699 Synthesis of dolichyl-phosphate mannose DPM3 DPM1 DPM2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH JUN SEL1L WWC1 NEURL1B DLGAP5 HES5 PTCRA MIB2 ITCH PBX1 MIB1 HEYL ATP2A3 NEURL1 TACC3 MAMLD1 ATP2A2 ATP2A1 YBX1 ELANE NUMB PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC MAML2 NOTCH2NLB MAML1 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 HDAC1 GZMB APH1A DLL4 PSENEN NCSTN APH1B CCND1 PSEN2 ADAM10 PSEN1 RBPJ TMED2 FCER2 TNRC6C MOV10 RFNG MFNG AGO3 B4GALT1 MDK AGO4 ACTA2 MYC AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 HIF1A YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HEY1 KAT2B KAT2A HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 NBEA FURIN DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 STAT1 CDK8 SMAD3 DTX4 JAG2 ADAM17 ARRB1 ARRB2 WWP2 EGF EGFR HDAC5 PLXND1 HDAC8 HDAC9 HDAC6 HDAC7 E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 HDAC10 EP300 HDAC11 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 TBL1X NCOR2 FABP7 NCOR1 TBL1XR1 SNW1 HDAC4 HDAC2 FLT4 HES1 CCNC CREBBP ST3GAL4 LFNG ST3GAL6 JAG1 ST3GAL3 SEM1 DLL1 SKP1 CUL1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 95%5358747 CTNNB1 S33 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis ARHGDIA NGFR LINGO1 NGF MAG OMG RTN4 MCF2 RHOA DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9734009 Defective Intrinsic Pathway for Apoptosis JUN PRDX2 PRDX1 CDK5 CDC25C CDKN2A CDC25B CDC25A C1QBP APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 TP53 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 95%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) RPS6KA1 CLTC CLTA AP2A1 AP2A2 NGF AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB VGF EP300 JUNB HRAS FRS2 MAP2K1 CRKL MAP2K2 PIK3CA SOS1 DUSP4 DUSP3 VRK3 DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 ADCYAP1 ADCYAP1R1 YWHAB SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA ATF1 BRAF MAP2K5 RAPGEF1 MAPKAPK3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTRK2 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin KLF4 INS GCG PCSK1 BCHE IGF1 SPCS3 SPCS2 LEP SPCS1 SEC11A UCN SEC11C ACHE MBOAT4 PLA2G7 CRHR2 GH1 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation BTRC DDB1 COPS7B COPS7A CUL4A COPS3 LRR1 COPS6 CCNF COPS5 COPS8 FBXO7 FBXO9 WSB1 FBXO2 CDKN1A FBXL18 FBXL7 SQSTM1 FBXL8 FBXL4 DTL LRRC41 UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 HIF3A PSMD7 ELOB ELOC SOCS2 PSMD2 KLHL2 RBX1 SOCS6 KLHL3 PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL KLHL9 SPSB2 SPSB1 DCAF8 KBTBD6 DCAF5 KLHL5 DCAF4 PSMA5 DCAF6 PSMA6 WSB2 PSMA3 KBTBD7 OBSL1 PSMA4 KBTBD8 DCUN1D5 PSMA1 SPSB4 DCUN1D3 DCUN1D4 PSMA2 DCUN1D1 DCUN1D2 FBXO27 UBA52 COMMD8 PUM2 NPLOC4 PSMD12 DDA1 PSMD11 ANKRD9 FBXO21 UBXN7 PSMD14 COMMD2 FBXO22 COMMD1 PSMD13 COMMD6 COMMD7 PSMA7 COMMD4 FBXW12 COMMD5 PSMB6 SPSB3 FBXW8 PSMB7 CCDC8 CISH PSMB4 FBXO17 CUL9 DPP3 UFD1 PSMB5 FBXO15 UBD NAE1 DCAF7 UBB SOCS5 PSMB2 WDTC1 PSMB3 LMO7 CCDC22 FBXO10 COMMD10 UCHL3 FBXO11 UBC TULP4 FBXO4 PSMB1 KLHL41 DCAF16 KCTD7 DCAF17 FBXO6 DDB2 RPS27A FEM1C DCAF10 KLHL42 DCAF11 FEM1A FBXW4 CUL7 FEM1B FBXW5 CUL5 NEURL2 NEDD8 FBXW10 ADRM1 ERCC8 FBXW7 PSMC5 FBXW9 PSMC6 KLHL11 PSMC3 PSMC4 FBXW2 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 FBXL3 UBA3 FBXL5 MUL1 UBE2M GPS1 KBTBD13 CUL3 VCP COPS4 COPS2 ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 ASB16 FBXL20 ASB10 WDR5 SENP8 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 SKP2 RBBP5 ASB1 RBBP7 COP1 SOCS3 COMMD9 FBXO32 BIRC5 DCAF13 COMMD3 KCTD6 AMER1 UBE2D1 BRCA1 CAND1 NFE2L2 FBXW11 FBXL21P PALB2 SEM1 SKP1 CUL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 95%3359474 Defective MMACHC causes MAHCC MMACHC RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.4 RHOBTB2 GTPase cycle HNRNPC CCT6A CCT7 RBMX DBN1 HSP90AA1 CDC37 HSP90AB1 TWF1 CCT2 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B CUL3 PHIP TXNL1 SRRM1 TRA2B ACTG1 MYO6 STK38 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME%R-HSA-445989.10 TAK1-dependent IKK and NF-kappa-B activation TRAF2 RELA MAP3K7 NFKB1 TRAF6 UBA52 USP14 NFKB2 CHUK NOD1 NKIRAS1 NOD2 NKIRAS2 USP18 IKBKG UBB IKBIP RIPK2 IKBKB UBC RPS27A ALPK1 LRRC14 NLRX1 IRAK1 UBE2V1 NLRC5 NFKBIA AGER IRAK2 TIFA S100A12 TAB1 APP S100B SAA1 TAB3 TAB2 HMGB1 TP53 NFKBIB CASP8 UBE2N THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 95%428930 Thromboxane signalling through TP receptor GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 TBXA2R GNG7 AAMP GNA11 GNGT1 GNG8 GNA13 GNGT2 GNG10 GNG12 GNG11 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes SRPRB ATP6V0D1 TPP1 CXXC1 PREB HDGF PPP2R5B KDELR3 ACADVL SHC1 ADD1 PDIA6 DNAJB11 DCTN1 SERP1 WFS1 SEC31A TLN1 DNAJC3 EXTL2 CUL7 FKBP14 GOSR2 MYDGF EXTL3 PLA2G4B HYOU1 EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 GSK3A EDEM1 WIPI1 YIF1A SYVN1 ARFGAP1 PDIA5 CTDSP2 SRPRA ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 95%2033519 Activated point mutants of FGFR2 FGF18 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.3 PI5P Regulates TP53 Acetylation PIN1 PIP4K2A TP53 ING2 PIP4K2B MAP2K6 PIP4P1 EP300 PIP4K2C ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9034793 Activated NTRK3 signals through PLCG1 NTRK3 NTF3 PLCG1 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 RIPK1 TBK1 IRAK1 IRF3 NFKBIA TAB1 TRAF2 TRAF3 TRAF6 FADD BIRC2 BIRC3 USP14 BTRC RIPK3 NOD1 NOD2 USP18 PPP2R1B PPP2R1A TICAM1 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA PPP2CB TLR3 MEF2C UBE2D2 UBE2D3 IKBKE IRF7 TANK UBE2D1 MAPKAPK2 UBA52 NFKB2 ATF1 NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 OPTN NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes CREBBP TALDO1 MAFG PGD NFE2L2 TKT EP300 G6PD CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME DATABASE ID RELEASE 95%390466 Chaperonin-mediated protein folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL STAT3 GNB4 GNB3 FBXL3 GNB5 FBXL5 WRAP53 TUBA8 GNGT1 TUBA1C CCT2 HDAC3 TUBA1B GNGT2 TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 CCT7 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 CCNE2 GBA1 ACTB CCNE1 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 GNG10 GNG12 GNG11 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells FGF10 ONECUT3 ONECUT1 PDX1 NKX6-1 PTF1A HNF1B RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination CRCP POLR3GL POLR3A POLR3B POLR3C POLR2E POLR3D POLR2F POLR3E POLR3F POLR2H POLR3G NFIX POLR3H SSB POLR2K NFIA POLR3K POLR2L NFIB NFIC POLR1C POLR1D ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1A CDKN1C RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 CDK2 E2F3 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 DEPURINATION%REACTOME DATABASE ID RELEASE 95%73927 Depurination H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription DHFR PCNA ORC1 TK1 CDT1 CDC6 HDAC1 CDK1 RRM2 E2F1 RBBP4 CDC45 FBXO5 TFDP1 TFDP2 LIN54 LIN37 CCNE1 LIN9 POLA1 TYMS LIN52 E2F4 E2F5 E2F6 CCNA1 RBL2 RBL1 FATTY ACIDS%REACTOME%R-HSA-211935.5 Fatty acids CYP2F1 CYP4A22 CYP4B1 CYP2D6 CYP4F12 CYP4F22 CYP4F3 CYP4F8 CYP2A13 CYP2B6 CYP2J2 CYP4F2 CYP4A11 CYP2A7 CYP4F11 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates MUS81 FIRRM BLM SLX4 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1LW ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 95%9026519 Activated NTRK2 signals through RAS HRAS SOS1 NTF4 NTRK2 BDNF NRAS DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency MCCC2 PC ACACA PCCA HLCS MCCC1 PCCB CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717323 ceritinib-resistant ALK mutants ALK VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNS1 KCNS2 KCNS3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9948011 CASP5 inflammasome assembly CASP5 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO3 FMO1 FMO2 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 95%9629569 Protein hydroxylation DRG2 RCCD1 ZC3H15 JMJD6 ASPH U2AF2 RIOX2 RPS6 F9 RPL8 RWDD1 JMJD4 KDM8 RPS23 JMJD7 RIOX1 ETF1 OGFOD1 RPL27A DRG1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR2 TGFB1 TGFBR1 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 95%9824443 Parasitic Infection Pathways JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.5 Carnitine synthesis TMLHE SHMT1 BBOX1 ALDH9A1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 95%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP RBPJ MAML2 MAML1 KAT2B ONECUT3 KAT2A ONECUT1 HES1 SNW1 EP300 NEUROG3 HNF1B MAMLD1 MAML3 NOTCH1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 95%6802949 Signaling by RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 95%9604323 Negative regulation of NOTCH4 signaling YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 TACC3 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 CUL1 NOTCH4 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange BLM MRE11 BRCA1 BRCA2 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 95%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 LIN52 HDAC1 CDK1 E2F4 E2F5 E2F1 RBBP4 CCNA2 TFDP1 TFDP2 LIN54 LIN37 MYBL2 LIN9 RBL2 RBL1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type CYP2E1 CYP3A7 RXRA CYP51A1 CYP2F1 CYP4B1 CYP2W1 ARNT2 CYP4F3 CYP11A1 CYP4F8 CYP2J2 NCOA1 CYP27A1 CYP39A1 CYP11B2 CYP27B1 CYP26A1 CYP26B1 ARNT CYP24A1 CYP4A22 CYP26C1 CYP2R1 CYP21A2 AHRR PTGIS CYP4F12 CYP3A5 CYP2A13 NR1H4 AHR NCOA2 CYP4F22 CYP19A1 POMC CYP7B1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP7A1 CYP1A1 CYP1B1 CYP2C19 CYP4F11 CYP11B1 TBXAS1 CYP2D6 FDXR POR CYP8B1 CYP2C18 CYP2B6 CYP46A1 CYP2S1 CYP4V2 FDX1 CYP3A4 CYP3A43 FDX2 CYP2A7 CYP2A6 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5682910 LGI-ADAM interactions CACNG2 CACNG3 CACNG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 STX1B CACNG8 DLG4 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 95%1482922 Acyl chain remodelling of PI PLA2G2D PLA2G2E MBOAT7 PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4C PLAAT3 PLA2G2A PLA2G1B PLBD1 PLA2G2F PLA2G4A DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9661070 Defective translocation of RB1 mutants to the nucleus RB1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism ME3 ME2 VDAC1 WDR26 PDHB RMND5B PC LDHA UBA52 MAEA PDPR RMND5A ME1 NEK1 PDK3 DLAT PDK2 LDHC MPC1 PDK1 LDHB MPC2 PDHX PDHA2 PDHA1 SIRT4 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 UBB PDP2 GLO1 GID4 GID8 UBC FAHD1 MPC1L RPS27A LDHAL6A LDHAL6B PDK4 GPT DLD SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9669933.2 Signaling by kinase domain mutants of KIT KIT DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764560.1 Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 STRAP HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 TFAP2A HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A ARID1A FOXA2 TGIF2 EED RB1 RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX KLF4 H2AB1 SP1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1660661 Sphingolipid de novo biosynthesis CYB5B SPTLC1 OSBP SPNS2 SPTLC2 SPTLC3 CSNK1G2 VAPA ABCG2 KDSR MFSD2B SPHK1 FA2H ORMDL2 ORMDL3 SPTSSB DEGS1 SPTSSA DEGS2 SPHK2 SAMD8 SGMS1 CERS3 ORMDL1 SGMS2 CERS4 ABCC1 CERS5 CERS6 CERS1 CERS2 PPM1L VAPB PRKD3 PRKD2 PRKD1 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%186712 Regulation of beta-cell development HNF1A MAFA RFX6 INSM1 FOXA3 GCK ONECUT3 ONECUT1 HES1 PDX1 INS NKX6-1 PTF1A PAX6 SLC2A2 MAMLD1 RBPJ CREBBP MAML2 IAPP FGF10 MAML1 KAT2B KAT2A FOXO1 EP300 SNW1 AKT2 NEUROG3 HNF1B HNF4G MAML3 AKT1 FOXA2 NEUROD1 NOTCH1 NKX2-2 AKT3 PAX4 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT PRKCA FES SOS1 STAT5A STAT5B PTPRU SH2B2 LYN CMA1 STAT3 PIK3R2 CBL FER PIK3R1 TEC GRAP NRAS GRAP2 JAK2 STAT1 SOCS1 CHEK1 MMP9 PTPN11 PTPN6 GRB10 YES1 RAC1 HRAS LCK FYN KIT SOCS6 SH2B3 GRB7 GAB2 PIK3R3 PIK3CA VAV1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 YWHAE YWHAQ YWHAG ZNF385A YWHAH BTRC UBE2V2 UBE2N HERC2 PLK3 CDKN1A CDKN2A CDC7 CDK2 CDC45 MDC1 PHF20 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 PSMD1 SFN YWHAZ PSMA5 PSMA6 PIAS4 PSMA3 PSMA4 BRCC3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 BABAM1 PSMB6 BABAM2 PSMB7 PSMB4 UIMC1 PSMB5 CSNK1E UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 CCNB2 CDC25A PKMYT1 WEE1 CLSPN MDM2 MDM4 NUP107 NUP160 RNF168 NUP85 NSD2 NUP43 RANBP2 SEC13 CDC25C NUP133 CDKN1B ABRAXAS1 TP53BP1 NUP37 ERCC6L ZWILCH BUB1B CCNE2 CDC20 NEK11 PPP1CC CCNE1 PPP2R1B H2AX PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 COP1 H2BC26 SGO2 H2BC12L DYNC1LI2 H2BC21 ZW10 MAD1L1 RNF8 CDCA8 PMF1 SKA1 CHEK2 SKA2 DSN1 H2BC17 H2BC12 H2BC13 H2BC14 RCC2 H2BC15 NDC80 ZWINT H2BC11 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 GSK3B CSNK1A1 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 GTSE1 RFC4 RMI1 PCBP4 RFC2 FBXW11 TOP3A RPA1 HUS1 RPA2 SEM1 RAD50 MCM7 MCM8 RPA3 SKP1 RAD17 RAD1 CCNA2 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 CLIP1 CUL1 ORC5 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 95%176187 Activation of ATR in response to replication stress ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25C CDC25A CDC7 CDK2 CDC45 CHEK1 ATRIP CLSPN RFC5 RFC3 RFC4 RFC2 MCM10 RPA1 DBF4 HUS1 RPA2 MCM7 MCM8 RPA3 RAD17 RAD1 MCM3 MCM4 RAD9B MCM5 MCM6 ATR MCM2 RAD9A ORC5 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%2033514 FGFR3 mutant receptor activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 95%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) GYG1 GYS1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181430 Norepinephrine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B SLC22A2 SLC22A1 MAOA PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.4 Regulation of FZD by ubiquitination FZD5 FZD4 UBC FZD6 RPS27A USP8 FZD8 UBA52 RSPO3 WNT3A LRP5 RNF43 ZNRF3 RSPO2 RSPO1 LGR6 LRP6 LGR5 RSPO4 LGR4 UBB RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037628 Rhesus blood group biosynthesis RHCE RHD DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 95%4724289 Defective ALG6 causes CDG-1c ALG6 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest SFN PCNA CCNB1 EP300 PRMT1 CDC25C AURKA CDK1 E2F4 BAX TP53 CARM1 TFDP1 TFDP2 GADD45A RBL2 RBL1 ZNF385A OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 95%9673163 Oleoyl-phe metabolism PM20D1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 95%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 DAG1 POMT2 POMT1 MMR%REACTOME%R-HSA-5358508.3 MMR LIG1 PCNA MSH6 POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%163615 PKA activation ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB NBEA CALM1 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 95%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 KPNA5 ARIH1 KPNA3 PIN1 EIF2AK2 ISG15 MAPK3 STAT1 EIF4E IRF3 RIGI NUP205 POM121 NUP107 TRIM25 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 UBE2E1 NUP88 NUP43 RAE1 NEDD4 KPNA1 NDC1 RANBP2 SEC13 UBA52 PLCG1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 NUP35 NUP54 NUP37 JAK1 KPNB1 USP18 UBB EIF4E3 IFIT1 PPM1B EIF4E2 UBC FLNB MX2 RPS27A MX1 EIF4G3 EIF4G2 UBA7 EIF4A2 EIF4A1 KPNA2 EIF4G1 UBE2L6 EIF4A3 HERC5 UBE2N MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.5 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 HSPB1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 HSPA1A EIF4G1 PSMD2 PSMD3 PSMD1 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.4 Leukotriene receptors LTB4R2 GPR17 CYSLTR1 CYSLTR2 LTB4R NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 95%9717301 NVP-TAE684-resistant ALK mutants ALK CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME%R-HSA-5637810.3 Constitutive Signaling by EGFRvIII SOS1 HSP90AA1 SHC1 EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 95%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU FURIN FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.2 FOXO-mediated transcription of cell death genes CREBBP CITED2 BBC3 STK11 BCL6 FOXO1 EP300 NFYA NFYB NFYC BCL2L11 FASLG FOXO3 PINK1 FOXO4 DDIT3 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 95%181429 Serotonin Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 TSPOAP1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%2122948 Activated NOTCH1 Transmits Signal to the Nucleus NEURL1B UBA52 DNER APH1A DLL4 MIB2 ITCH PSENEN DTX1 NCSTN MIB1 DTX2 APH1B NUMB PSEN2 DLK1 NEURL1 ADAM10 CNTN1 PSEN1 UBB UBC RPS27A DTX4 JAG2 JAG1 ADAM17 DLL1 ARRB1 ARRB2 NOTCH1 CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis NKX2-5 LEF1 ISL1 CTNNB1 SRF KAT5 FOXO4 SMAD1 SMAD4 HEY1 MEF2C KAT2A HAND2 MESP1 HEY2 GATA6 TBXT TBX20 SMYD1 TBX1 EOMES MYOCD HAND1 LDB1 TBX5 WDR5 GATA4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 95%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 SERPINB13 CTSV SOCS3 CTSL CTSK CBFB SOCS4 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 APOB S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 GSDMD BIRC3 GSDME USP14 BTRC TLR7 RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 HSP90B1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 LGMN MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB UNC93B1 SIGIRR TLR3 IRAK3 MEF2C CTSS UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 CNPY3 SAA1 TAB3 TLR8 SKP1 TAB2 CTSB TP53 NFKBIB FOS CTSV ELK1 CTSL CTSK MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME%R-HSA-5683371.5 Defective ABCB6 causes MCOPCB7 ABCB6 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus WWP2 EGF EGFR NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 TACC3 PSEN1 UBB UBC RPS27A YBX1 JAG2 JAG1 DLL1 NOTCH3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 95%446205 Synthesis of GDP-mannose PMM1 MPI HK1 GMPPB PMM2 GMPPA PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 RBBP4 HLA-DRB5 TRAV19 RBBP5 HLA-DRB4 RBBP7 HLA-DPB1 TRAV8-4 HLA-DRA CDK4 HLA-DRB3 CD4 HLA-DRB1 H2AX HLA-DQB2 H2AB1 HLA-DQB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PTPN11 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 CSK PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 PTPN6 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%391160 Signal regulatory protein family interactions CD47 SIRPB1 PTK2B SIRPA FYB1 SIRPG PTPN6 PTK2 SKAP2 TYROBP PTPN11 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFAM TFB2M NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJA1 GJB2 GJB1 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 95%392451 G beta:gamma signalling through PI3Kgamma GNG13 GNB2 GNB1 GNB4 GNB3 PIK3CG PIK3R6 GNB5 PIK3R5 GNGT1 RHOA GNGT2 GNG3 GNG2 GNG5 GNG4 AKT2 GNG7 GNG8 PDPK1 GNG10 AKT1 GNG12 AKT3 GNG11 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels KCNJ2 KCNJ4 KCNJ14 KCNJ12 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 95%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP TXNIP SIRT1 KAT2B SIRT3 FOXO3 FOXO1 EP300 TXN FOXO4 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9705677.2 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 PALS1 PATJ TJP1 CRB3 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome CASP1 NLRC4 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 LYN EPO EPOR IRS2 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 95%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP1 HLA-H PIK3R4 HLA-B SEC13 HLA-C ATG14 HLA-F HLA-G HLA-E BECN1 HSPA5 SEC24D PDIA3 SEC24C TAP2 SAR1B SEC31A TAP1 TAPBP CANX CALR SEC23A B2M HLA-A SEC24B SEC24A ERAP2 PIK3C3 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.3 Beta-catenin phosphorylation cascade FRAT2 APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 FRAT1 PPP2R1A PPP2R5E PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8849474 PTK6 Activates STAT3 PTK6 STAT3 SOCS3 STAP2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9613829 Chaperone Mediated Autophagy CETN1 PARK7 UBC RNASE1 GFAP CFTR PLIN3 RPS27A HSP90AA1 HSPA8 UBA52 ARL13B HSP90AB1 HBB HDAC6 PCNT EEF1A1 PLIN2 LAMP2 IFT88 UBB SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME DATABASE ID RELEASE 95%1839130 Signaling by activated point mutants of FGFR3 FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGFR3 FGF20 FGF16 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome DDX5 ZCRB1 VHL RB1 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System KCNJ8 AP2A1 KCNJ11 ABCC8 ABCC9 ADCY9 NTRK3 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT RTN3 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 DBNL KCNK6 KCNK7 KCNK1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 GRM1 GRM5 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 FLOT1 FLOT2 ARHGEF9 EPB41L3 GJC1 GJA10 GJD2 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 KCNG1 KCNG2 BCHE KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 PRKCA KCNK17 KCNK18 KCNQ1 KCNQ2 KCNQ3 SNAP25 KCNQ4 RAB3A KCNQ5 SLC32A1 KCNV1 SYT1 SLC6A13 KCNV2 ABAT KCNN1 KCNN3 SLC6A1 KCNN4 CPLX1 RIMS1 KCNF1 KCNC1 ALDH5A1 KCNK9 DNAJC5 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 GIT1 KCNAB1 KCNAB2 KCNAB3 KCNA10 IL1RAPL1 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNB1 KCNB2 KCNJ14 KCNS1 KCNS2 KCNS3 HSPA8 KCNK2 VAMP2 KCNK3 HCN2 KCNK4 HCN1 SLITRK3 CAMKK1 CAMKK2 SLITRK5 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 SYT2 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 KCNN2 PTPRF SYN3 SYN2 HRAS SLC6A11 PDPK1 PTPRS ARL6IP5 HOMER3 CACNA2D1 CACNA2D3 EPB41 STXBP1 EPB41L5 NRAS EPB41L2 HOMER1 HOMER2 CHAT PPFIBP1 PPFIBP2 GRIP1 MAPK1 GNAT3 SLC6A4 PANX1 CHRNB2 PANX2 NSF SIPA1L1 CHRNB4 DLGAP1 CHRNB3 GABRG3 DLGAP3 DLGAP2 GRIP2 GABRG2 SLC18A3 DLGAP4 CHRNA1 BEGAIN CHRNA3 SLC17A7 CHRNA2 MAPK3 APBA3 CHRNA5 APBA2 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 SHARPIN GRIK4 LRRC4B GRIK1 SYT9 GRIK2 GRIA1 SYT7 GABRR3 LRRTM3 CAMK2B GABRR2 GRIA2 LRRTM4 GABRR1 LRRTM1 CAMK2D LRRTM2 NPTN SRC ACTN2 HTR3E IL1RAPL2 HTR3C SHANK3 CAMK2A HTR3D NRG1 SHANK2 GRIN2C HTR3A SHANK1 GRIN2B HTR3B NLGN3 PICK1 NRGN NLGN1 GRIN2D GNAI3 NLGN2 AKAP5 GRIN1 NRXN1 GNAI1 DLG1 NRXN3 GRIN2A NRXN2 NCALD GNAI2 DLG2 SLITRK2 CHRND DLG3 SLITRK1 LRRC7 GLRA1 SLITRK4 DLG4 CACNG8 SLITRK6 NEFL GLRA2 PDLIM5 CALM1 GLRA3 NLGN4Y CHRNG CAMK2G NLGN4X SYT10 CHRNE SYT12 CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME DATABASE ID RELEASE 95%5467337 APC truncation mutants have impaired AXIN binding APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E PI3K AKT SIGNALING%REACTOME%R-HSA-1257604.12 PI3K AKT Signaling JUN NTRK3 NTF3 PDGFB IRAK1 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PDGFRA RAC1 KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 ESR2 HDAC2 SRC NR4A1 NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 GSK3B IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 PYROPTOSIS%REACTOME DATABASE ID RELEASE 95%5620971 Pyroptosis IRF1 IRF2 CYCS CHMP3 CHMP6 CHMP7 BAK1 ELANE GZMB GSDMD GSDME BAX TP63 IL18 IL1A IL1B CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A HMGB1 TP53 CASP5 CASP1 CASP4 CASP3 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 95%111452 Activation and oligomerization of BAK protein BID BAK1 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%110381 Resolution of AP sites via the single-nucleotide replacement pathway XRCC1 POLB LIG3 APEX1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614558 Degradation of cysteine and homocysteine CTH FMO1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 TST ETHE1 SLC25A10 CDO1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 95%420092 Glucagon-type ligand receptors GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 GCGR GNGT1 GCG GNGT2 GIP GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ADCYAP1 ADCYAP1R1 GNG10 GNG12 GNG11 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B TFAP2A CDKN1A TFAP2C MYC DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation PRKAG3 PPARGC1A MAPK12 PRKAB2 PRKAA2 MAPK14 MAPK11 PRKAG1 PRKAB1 PRKAG2 RAC1 GTPASE CYCLE%REACTOME%R-HSA-9013149.2 RAC1 GTPase cycle ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 FAM13B WIPF1 WIPF2 CYFIP2 WIPF3 ARHGAP44 PREX2 DOCK11 ARHGDIA NISCH RALBP1 ARHGAP45 SPATA13 ARHGEF25 CIT IQGAP1 PLD1 FGD5 IQGAP2 CHN2 IQGAP3 ARHGAP22 FARP2 ARHGAP20 SRGAP3 SRGAP1 ARHGAP29 ARHGAP27 ARHGAP24 PKN2 ARHGAP33 PKN1 ARHGAP31 FAM13A ARHGAP30 DOCK6 ARHGAP9 DOCK9 DOCK8 DOCK7 WASL ARHGAP4 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 ARAP1 GMIP ARHGAP10 CDC42EP4 TRIO RASGRF2 WAS PLEKHG6 PARD6A CHN1 PAK6 PREX1 SH3BP1 MCF2L PAK3 RAC1 WASF3 PAK5 FARP1 VAV3 MYO9B ARHGEF11 SRGAP2 ARHGEF10 CDC42BPA DEF6 PLEKHG2 KTN1 ARHGEF15 DLC1 PIK3R3 ARHGEF19 PIK3CA DIAPH3 ARHGEF18 ITGB1 VAV1 VAV2 TIAM2 TIAM1 SOS1 ARHGEF4 ARHGEF7 PIK3R2 SOS2 PIK3R1 ARHGEF5 NGEF ARHGEF6 KALRN GNA13 ABR SYDE2 ECT2 ARHGEF39 MCF2 ARHGAP12 PLD2 CDC42 ARHGAP25 ARHGAP23 DOCK5 DOCK4 FMNL1 DOCK3 LAMTOR1 ALS2 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 TFRC NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP35 DOCK10 ARHGAP42 BAIAP2L1 OPHN1 ARHGDIB EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 JAG1 SLC1A5 ARHGAP15 ARHGAP21 PAK1 RACGAP1 NHS ABL2 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 GIT2 CAV1 MCAM SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 95%111367 SLBP independent Processing of Histone Pre-mRNAs LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 ARID1A ARID1B RBL2 RBL1 IFNG ZNF197 ZNF195 NR2C2 NR2C1 THBS1 HSPD1 VEGFA ERBB2 HES1 GLS2 ZNF189 ZNF286A ZNF184 ZNF180 OPRK1 GLS ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 JAG1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 POU2F1 TRPC3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 LBR CAV1 TGFB1 STEAP3 ITGA2B ITGA5 SERPINE1 CHD3 BMI1 RING1 HDAC4 HDAC2 L3MBTL2 SATB2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 GSK3B AXIN1 GPI CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 CREBBP SP1 CAMK4 BDNF TGFA FOS FOXO3 AKT3 JUN AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X YY1 USP7 USP2 FOXO4 ATXN3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 MDM2 MDM4 PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP MAPK1 CSTF3 CSTF2 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 SNRPB SRSF9 RBM8A CPSF4 CHTOP CPSF1 ALYREF CPSF3 CPSF2 YBX1 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 KIT TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9703009 tamatinib-resistant FLT3 mutants FLT3 APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109581 Apoptosis XIAP CYCS ROCK1 H1-1 BID H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 VIM RIPK1 CLSPN DCC YWHAE YWHAQ YWHAG YWHAH TRAF2 TNFSF10 UNC5A KPNA1 DAPK1 UNC5B DAPK2 DAPK3 FADD BIRC2 CD14 GSDMD NMT1 GSDME PPP3CC C1QBP SPTAN1 E2F1 APPL1 DFFB DFFA DBNL ACIN1 TFDP1 KPNB1 TFDP2 GAS2 MAPT TLR4 BCAP31 GSN CARD8 TJP2 FNTA TICAM2 ARHGAP10 TICAM1 PKP1 LY96 AKT2 BMF BMX STK24 STK26 AVEN TRADD HMGB2 APIP PRKCQ HMGB1 CASP8 PPP3R1 TP53BP2 DNM1L DSP OMA1 OCLN OPA1 DSG1 DSG3 TNFRSF10B TNFRSF10A PLEC STAT3 DYNLL1 UACA ADD1 BAK1 GZMB CDKN2A MAGED1 DYNLL2 MAPK1 PPP1R13B MAPK8 CTNNB1 BCL2L11 TJP1 FAS FASLG MAPK3 BAD PMAIP1 CDH1 YWHAB SATB1 PSMD8 PSMD6 PSMD7 PSMD2 CASP6 PSMD3 AKT1 PSMD1 PRKCD APC SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BAX PSMD13 TP63 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC BBC3 BCL2 DSG2 PSMB1 RPS27A BCL2L1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TP73 TP53 PAK2 PTK2 CASP9 CASP7 APAF1 DIABLO AKT3 CASP3 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.5 SOS-mediated signalling HRAS SOS1 NRAS IRS1 IRS2 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 95%5579011 Defective CYP2U1 causes SPG56 CYP2U1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 95%1236973 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CD36 ITGB5 CYBB CYBA ITGAV INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic KIF28P SCOC SYS1 KDELR1 GOLIM4 KDELR3 GCC2 GCC1 RAB43 RAB41 GOLGA5 KIF5C GOLGA1 ARFIP2 KIF21A KIF21B RHOBTB3 KIFAP3 KLC1 COG8 KLC4 COG7 KLC3 COG6 KLC2 COG5 COG4 COG3 COG2 COG1 RINT1 RAB30 RAB36 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 ARL1 KIF3B SEC22B MAN2A2 VTI1A KIF3C RAB9A RAB6B RAB9B KIF5B RAB39A KIF5A KIF18B KIF4B ALPP KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 M6PR MAN1A2 KIF13B TMED3 VPS45 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 KIF6 BET1L STX5 KIF27 COPZ1 RAB33B KIF9 KIFC2 KIFC1 NAA35 NAA38 VAMP4 PAFAH1B3 ARF5 NAPA GBF1 TGOLN2 NAPB NBAS TMF1 RAB6A STX16 RAB1A STX18 RAB1B GOSR1 NAPG STX10 CYTH3 ARFRP1 CYTH2 GALNT1 CYTH4 CUX1 VPS51 VPS53 VPS52 MAN1C1 SNAP29 BNIP1 ARFGAP3 STX6 ARFGAP2 VPS54 DYNC1LI1 CAPZB CYTH1 RIC1 DYNC1LI2 GALNT2 ARCN1 ZW10 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF MAN2A1 KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 PLIN3 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 IGF2R ACTR1A ARF1 GOLGA4 VAMP3 DCTN2 CAPZA1 DCTN3 GOSR2 RACGAP1 YKT6 ARFGAP1 USP6NL HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022928 HS-GAG biosynthesis HSPG2 HS3ST3A1 SDC4 SDC2 SDC3 HS6ST1 HS6ST2 HS2ST1 HS6ST3 SLC35D2 NDST2 AGRN NDST1 EXTL2 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9759475 Regulation of CDH11 Expression and Function JUP PRDM8 CTNND1 BHLHE22 CDH8 CTNNA1 CDH24 HOXC8 FOXF1 HEYL ADAM33 ADAM19 CTNNB1 ILF3 ZEB2 CDH11 SNAI1 ANGPTL4 SP1 TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.3 Toll Like Receptor 5 (TLR5) Cascade RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1793185 Chondroitin sulfate dermatan sulfate metabolism CSPG4 GUSB ARSB CHST3 CHST14 DSEL DSE UST CHST15 IDUA CHPF NCAN HEXB CHSY1 HEXA CHST11 CHST12 BGN GLB1L3 CHSY3 CHST13 DCN GLB1L2 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 95%4043916 Defective MPI causes CDG-1b MPI NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors LPAR4 ADORA2B GPR17 P2RY10 P2RY11 LPAR6 ADORA2A P2RY12 P2RY6 P2RY13 P2RY2 P2RY14 P2RY1 P2RY4 ADORA3 ADORA1 MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205647 Mitophagy MAP1LC3A FUNDC1 VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 ULK1 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN CSNK2A1 TOMM40 CSNK2A2 UBE2D2 UBE2D3 CSNK2B MTERF3 PINK1 UBE2N NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes CREBBP GEM ARNT NAMPT CDK5 RBFOX3 INS PLK2 NPAS4 MDM2 IQSEC3 MAPK1 ARNT2 BDNF XPO1 FOS BMAL1 CDK5R1 MAPK3 RET SYT10 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 95%8985947 Interleukin-9 signaling JAK3 STAT5A STAT5B STAT3 IL9 JAK1 STAT1 IL2RG IL9R SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 95%5654688 SHC-mediated cascade:FGFR1 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B ABCA12 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.3 Signal amplification GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNA13 GNGT2 GNAT3 PLA2G4A GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 TBXA2R GNG7 AAMP MAPK14 GNA11 GNG8 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 P2RY1 GNG12 GNG11 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 95%9022699 MECP2 regulates neuronal receptors and channels FKBP5 PTPN4 GPRIN1 GRIA2 HDAC1 HDAC2 OPRK1 GRIN2B SIN3A SLC2A3 MET GRIN2A TRPC3 OPRM1 PTPN1 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 95%73854 RNA Polymerase I Promoter Clearance H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A HDAC1 H2AC20 ERCC6 MBD3 RRN3 MAPK3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L MTA2 GTF2H1 GTF2H2 GTF2H3 RBBP4 MBD2 MTA1 GTF2H4 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 95%9006335 Signaling by Erythropoietin PIK3CB RAPGEF1 SOS1 STAT5A STAT5B SHC1 PIK3CD LYN PIK3R1 PIK3CG PIK3R5 NRAS PLCG1 HRAS JAK2 GAB1 PLCG2 CRKL PIK3CA EPO VAV1 EPOR IRS2 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis UBC ENO1 TRIM27 RPS27A RAB7A KPNA1 SFPQ UBA52 ATP6V1H MAPK1 NOS2 CTSG VPS33B DUSP16 CORO1A PGK1 HGS RNF213 RAB5A GSK3A KPNB1 MAPK3 UBB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB ACADL HADHA ACADM DECR1 ECI1 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation GNG13 ARHGEF9 GNB2 GNB1 ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 GNAT3 GABRG3 GABRG2 GABRB3 GABRB2 GABRB1 GNG3 GNG2 GABRR3 GNG5 GABRR2 GNG4 GABRR1 GNG7 NPTN GNG8 GNAI3 GNAI1 GNAI2 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GABRA3 KCNJ15 KCNJ16 GNG10 GNG12 GNG11 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME%R-HSA-4719377.4 Defective DPM2 causes CDG-1u DPM3 DPM1 DPM2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 95%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IQGAP1 GNG13 GNB2 GNB1 GNAS GNB4 GNB3 GNB5 ADCY8 GNGT1 KCNC2 ADCY6 GCG ADCY5 GNGT2 RAP1A PRKACG PRKACA PRKACB GLP1R RAPGEF3 RAPGEF4 KCNB1 GNG3 ITPR1 KCNS3 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A KCNG2 AKAP5 GNG10 GNG12 GNG11 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors ADRA2C ADRA2B ADRB1 ADRA2A ADRA1D ADRB2 ADRB3 ADRA1B ADRA1A NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes CREBBP MAFK NFE2L2 EP300 CCL2 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 95%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 95%9757110 Prednisone ADME UGT2B7 ABCB1 UGT1A3 AKR1C1 CYP3A4 HSD11B1 HSD11B2 ALB UGT2B17 SERPINA6 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex UBC TAB3 RPS27A TICAM1 TLR3 TAB2 MAP3K7 TRAF6 UBA52 UBB TAB1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%191859 snRNP Assembly SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 95%170834 Signaling by TGF-beta Receptor Complex NEDD4L ITGB8 ITGB5 SERPINE1 PMEPA1 FURIN PARP1 BAMBI STRAP HDAC1 RHOA TGFB1 TGFBR1 UBE2M ITGB6 TGFBR2 MAPK1 ITGA8 SKIL PPP1R15A MAPK3 TGFB2 ATP1B4 TGFB3 SKI CDK8 NCOR2 SMAD2 MTMR4 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC SMURF1 TGFBR3 E2F4 FKBP1A CCNT2 PPM1A E2F5 UBE2D3 XPO1 RBL1 TGIF1 STUB1 UBE2D1 TGIF2 TRIM33 CCNK CBL CCNC UBA52 CDKN2B COL1A2 PPP1CA USP15 CCNT1 TFDP1 TFDP2 PPP1CB PPP1CC UBB UBC SP1 UCHL5 RPS27A CDK9 EP300 JUNB PARD6A NEDD8 CGN F11R RNF111 MEN1 PRKCZ WWTR1 PARD3 USP9X LTBP4 ITGB3 ARHGEF18 ITGB1 LTBP3 ITGAV LTBP1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 95%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 95%174577 Activation of C3 and C5 C4A C3 CFB C4B_2 C2 C5 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 95%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 LTC4S PON3 ALOX5AP PON2 PON1 GPX2 GPX1 ALOX5 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins FZD2 FZD5 FZD7 WNT5A FZD4 PRICKLE1 FZD1 FZD8 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 SCRIB VANGL2 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PARD6A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 DVL2 PSMC1 PSMC2 FZD3 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance CLTB ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 TYROBP DOCK1 ERBB2 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM ANK1 SEM1 FYN CLTC CLTA AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 MSI1 COL6A2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 ROCK1 ROCK2 CNTN1 DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 YES1 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization PDGFB CTSG PRSS2 KLK2 A2M PECAM1 P4HB TIMP1 BMP2 PLG LAMA5 LAMA2 PPIB LAMB3 LAMC3 LAMB2 LAMA1 P4HA1 LAMA4 ELANE P4HA2 LAMA3 FN1 P4HA3 LAMB1 LAMC2 LAMC1 VTN CAPNS1 CAPNS2 CAPN2 CAPN1 BMP7 CAST DAG1 MMP1 MMP2 MMP3 FBN2 FBN3 BMP10 ELN LTBP4 LOXL3 LOXL4 FBLN1 LTBP3 FBLN2 LTBP1 FBLN5 LOXL1 LOXL2 COL17A1 EFEMP2 COL15A1 COL16A1 EFEMP1 COL13A1 ITGB8 GDF5 COL14A1 COL11A1 PLEC MFAP5 COL11A2 BMP4 COL12A1 MFAP4 COL19A1 LOX COL10A1 MFAP3 COL28A1 MFAP2 FBN1 COL26A1 COL27A1 COL24A1 COL25A1 ACTN1 NCSTN COL22A1 COL23A1 COL2A1 ADAM10 COL5A1 PSEN1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 SDC4 COL5A2 COL8A2 SDC2 COL20A1 SDC3 COL4A6 COL6A3 COL21A1 COL8A1 COL4A5 COL6A6 COL6A5 NTN4 CDH1 CTSS SDC1 PRKCA KLKB1 COL1A1 COL1A2 ITGA10 PRSS1 ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 PHYKPL CTRB2 CTRB1 P3H2 P3H1 P3H3 OPTC KLK7 SERPINH1 DTNA DTNB SSPN CTSB DDR1 MMP20 MMP24 TPSAB1 MMP13 MMP10 MMP12 MMP11 MMP14 MMP16 CASP3 MMP15 COL18A1 MMP17 MMP19 ITGA3 DDR2 ITGB4 TMPRSS6 ITGA1 DRP2 NID1 DMD NID2 JAM2 ITGA6 FURIN JAM3 PLOD3 PLOD2 PLOD1 SPP1 CAPN8 CAPN9 CAPN6 TGFB1 CAPN7 CAPN5 CAPN3 PCOLCE ADAM15 ADAM12 ADAM9 UTRN CD151 HTRA1 SCUBE3 SNTG2 SCUBE1 CRTAP VCAM1 TRAPPC4 BMP1 ITGA11 COLGALT2 MMP25 ITGAE TIMP2 SGCE SGCD SGCA SGCB ITGB7 COLGALT1 SGCG ADAM17 SNTA1 ITGAD PCOLCE2 SPOCK3 SGCZ CAPN13 NCAN CAPN14 CAPN11 CAPN12 BGN CAPN10 TLL2 DCN TLL1 SNTB1 BCAN CASK SNTB2 VCAN CMA1 ADAM8 ITGAM SH3PXD2A ITGB2 FGF2 TTR F11R CTSD ITGB3 ITGA2B ITGB1 COL3A1 ITGAV COL4A2 NCAM1 COL4A1 ITGA5 ITGA9 PTPRS SPARC ITGB5 SERPINE1 TNC DMP1 HAPLN1 COMP IBSP TNN ITGAX TNR ITGB6 MUSK ITGA2 HSPG2 ASPN ITGA8 MATN1 ITGA7 MATN4 MATN3 ITGAL TNXB LRP4 ACAN TGFB2 CEACAM6 LUM CEACAM8 TGFB3 CD47 DSPP COL9A1 CD44 ITGA4 COL9A3 COL9A2 AGRN FMOD ADAMTS4 ADAMTS5 NRXN1 ADAMTS2 ADAMTS3 ADAMTS1 ADAMTS8 KDR ADAMTS9 THBS1 ADAMTS16 ADAMTS14 ADAM19 FGB ADAMTS18 FGA MMP8 FGG MMP9 PDGFA CEACAM1 PXDN BSG CTSV CTSL MMP7 CTSK TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.6 TNFR1-induced proapoptotic signaling XIAP TRAF2 FADD USP4 BIRC2 USP2 BIRC3 MIB2 CYLD RBCK1 OTUD7B RIPK1 USP21 SHARPIN TNF TBK1 OPTN TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP RIPK1 TBK1 IRAK1 IRF3 NFKBIA TLR1 BPI TAB1 S100A9 S100A8 TLR2 PLCG2 LBP TRAF2 TRAF3 TRAF6 FADD BIRC2 CD14 BIRC3 USP14 BTRC RIPK3 NOD1 ITGAM ITGB2 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 CD180 LY86 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK DNM1 DNM2 MAPK3 SOCS1 ATF2 PTPN11 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C UBE2D2 UBE2D3 TLR6 DNM3 IKBKE IRF7 TANK CD36 PTPN4 UBE2D1 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 OPTN PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9929356 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 NEK2 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 COPS5 PSMD3 PSMD1 GSK3B CUL1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism AGPAT2 GPAM PLA2G4A PLA2G2A RAB5A PIP4K2A PIP4K2B LIPI PIP4K2C LIPH BMX STARD7 RUFY1 PLBD1 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 PTPMT1 PIP5K1A PIP5K1B CHKB CHKA STARD10 ARF3 ACHE MTMR14 LPCAT1 OSBPL10 GNPAT PIP4P1 GPAT4 GPAT3 CEPT1 BCHE AGK LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 LCLAT1 PIP5K1C PCYT2 PGP PLA2R1 INPP5D ABHD4 PIK3CG PIK3R6 ABHD3 PIK3R5 ARF1 OSBPL8 RAB4A OSBPL5 OCRL SYNJ2 SYNJ1 PIK3CD PIK3C2G PIK3C2B ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B TPTE AWAT2 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 RAB14 LPGAT1 PITPNB CPNE7 CPNE6 GDE1 CPNE1 CPNE3 MFSD2A SACM1L PISD PLA1A PGS1 PTDSS2 PTDSS1 INPP5J INPP5K TMEM86B PTEN MTMR1 PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 GDPD1 GDPD3 GDPD5 PIK3CB PNPLA7 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 ETNPPL PLEKHA8 PNPLA3 PNPLA6 PTPN13 INPPL1 PLB1 ENPP6 PIK3R3 SBF1 PIK3CA SBF2 TPTE2 PIK3C3 MIGA2 MIGA1 PLA2G15 PHOSPHO1 PIK3R4 PLA2G10 PIK3R2 GPD1 PIK3R1 INPP5E CHAT PLD4 PLD6 PLD3 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 PI4KA VAC14 PI4K2B PLD2 MTMR10 ALPI MTMR2 GPD2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A PCTP LPIN1 FIG4 LPIN2 INPP4B MGLL PLA2G4F PIKFYVE LPIN3 INPP5F PI4K2A PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 AGPAT5 PLA2G1B AGPAT1 SELENOI AGPAT3 AGPAT4 PLA2G2F PLA2G2D PLA2G2E CHPT1 GPD1L CDS1 PITPNM1 PITPNM3 PNPLA2 PITPNM2 CDIPT SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC MRE11 NLRC3 IFI16 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602571 TRAF3 deficiency - HSE TICAM1 TLR3 TRAF3 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.3 CHL1 interactions ITGA10 CHL1 ITGA2 ITGA1 ANK1 CNTN6 HSPA8 NRP1 ITGB1 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 95%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKAR2A PRKACG PPP3CB AKAP5 PRKACA PRKACB OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors NPFF QRFPR HCRTR1 QRFP NPFFR2 HCRT NPFFR1 HCRTR2 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC4 ADAR ADARB1 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%9623433 LXRs regulate gene expression to control bile acid homeostasis RXRA NR1H2 NR1H3 RXRB NCOR2 NCOR1 UGT1A3 FABP6 NCOA1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD APOA1 ABCA1 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 95%5693548 Sensing of DNA Double Strand Breaks RAD50 MRE11 KPNA2 ATM KAT5 NBN MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) LIG1 PCNA POLD3 POLD4 POLD1 POLD2 RPA1 RPA2 PMS2 MSH2 MSH3 MLH1 RPA3 EXO1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR5AL1 OR8H3 OR8H2 OR8H1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 TAS2R40 TAS2R41 TAS2R43 TAS2R46 OR10T2 KCNMA1 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 SLC17A8 OR2A25 OR51I2 ITPR3 TAS2R30 TAS2R31 LRP8 OR10S1 TAS2R38 KCNMB1 OR52K2 OR51I1 TAS2R39 OR52K1 CNGA2 APOB RPE65 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 ATP2B1 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 RDH8 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 TAS2R50 OR4D1 OR5F1 OR10Z1 NMT1 OR52R1 OR4C6 OR4C5 OR3A3 SPTAN1 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 HSD17B6 OR4C45 OR5AN1 OR4B1 OR4C46 GSN OR8J3 OR6F1 OR8J2 FNTA OR8J1 OR51M1 OTOP1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 PRKCQ OR5H14 OR2D3 OR52A4P CYP4V2 OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 CALHM1 OR6K2 CALHM3 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 CAPZA2 OR5H6 OR4F5 OR2B3 SDC4 OR4F4 OR2B2 SDC2 OR10K2 SDC3 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 GPC1 OR51A7 OR2A2 GPC3 TAS2R7 GPC2 OR52J3 GPC5 RTP2 GPC4 OR51H1 TAS2R8 GPC6 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 SDC1 OR6Q1 OR8U3 OR8U1 GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 OR51G2 OR51G1 OR52I2 SNAP25 OR52I1 RAB3A OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 DNAJC5 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 MSN OR2T35 OR2T33 TAS1R2 TAS1R1 TAS1R3 OR4F21 OR2T27 OR51E1 CAPZA1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LRP2 AWAT2 GNG13 GNB1 GNB3 GNGT1 RDH5 RLBP1 HSD17B1 CAPZB AKR1C1 TTR AKR1C4 PLB1 SPTBN1 CALM1 RDH11 RDH10 RDH16 AKR1C3 DHRS3 DHRS9 APOA2 APOA1 APOA4 LPL LDLR GPIHBP1 APOC3 TRPM5 TRPM4 MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 GRM1 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B PLCB2 MYO3A FSCN2 EZR TWF2 PCDH15 PDE6B CABP2 PDE6A USH1C CACNA1D CABP1 LRRC52 ESPNL PDE6G EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 LHX2 STX1A SCN1B OTOF SCN3A SCN2A SCN2B PRKCA KCNQ4 SCN9A SCN4B VAMP2 ABCA4 SCNN1G SCNN1D SCNN1B SCNN1A RBP4 RDH12 OPN1LW RBP1 LRAT STRA6 OPN1MW CASK OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 GUCY2D OR2AE1 GUCA1B OR11H6 GUCA1A OR11H7 GUCA1C OR2L8 GUCY2F OR1J4 GRK1 OR2L5 GRK7 OR11G2 FNTB OR1J2 RHO OR2L3 CNGA1 GNAT1 OR4P4 OR1J1 RCVRN OR2L2 CAMKMT OR10AD1 RGS9BP OR6T1 SAG OR4K15 NMT2 RBP3 PPEF1 OR4K14 METAP1 OR4K13 METAP2 OR13J1 CNGB1 OR7A2P CHRNA9 OR2K2 CHRNA10 OR1I1 KCNN2 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 GNAT3 OR1L1 OR5T3 HSPG2 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOE OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P EPB41L1 OR5AS1 OR2T8 OR2T7 OR2T6 AGRN OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 APOC2 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 KCNJ2 OPN1SW OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 LRP1 RETSAT OR6C74 OR14I1 APOM OR10A7 OR56A5 BCO2 OR7A5 BCO1 OR10A2 OR56A4 AKR1B10 CLPS OR10A4 RBP2 OR56A3 SLC24A1 OR10A3 LRP10 OR10A6 LRP12 OR56A1 PNLIP OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 TAS2R20 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 95%156587 Amino Acid conjugation GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation RXRA PPARGC1A PPARGC1B HDAC1 CIDEA MTA2 RBBP4 UCP1 MTA1 PRDM16 ZNF423 MBD3 MTA3 RBBP7 EBF2 NCOA1 BMP7 GATAD2B GATAD2A SMAD1 SMAD4 CHD3 COX7A1 HDAC2 ELOVL3 CHD4 HNRNPU PPARG PPARA SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802948.2 Signaling by high-kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL SRC YWHAB HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.5 Deactivation of the beta-catenin transactivating complex XIAP SOX17 APC SRY YWHAZ SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 TCF7L2 PYGO1 BCL9 TCF7L1 PYGO2 HDAC1 UBA52 LEF1 TCF7 TLE4 TLE2 TLE1 BTRC RBBP5 CTNNB1 CTBP1 UBB UBC ASH2L RPS27A KMT2B SOX2 AKT2 MEN1 SOX9 TLE3 XPO1 DPY30 WDR5 AKT1 CHD8 CBY1 SOX3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2500257.7 Resolution of Sister Chromatid Cohesion NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CDK1 CCNB2 CLIP1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467340 AXIN missense mutants destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 95%163841 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation FURIN JMJD6 RIOX2 BGLAP EIF5A DHPS FN3KRP EIF5A2 FN3K ICMT DOHH RPL8 STS RWDD1 JMJD4 KDM8 JMJD7 ARSA ETF1 RIOX1 OGFOD1 SUMF2 SUMF1 DRG1 DRG2 RCCD1 ZC3H15 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD F8 RPL27A ARSB ASPH U2AF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 RPS6 DPH6 DPH7 EEF2 F7 F9 PROC F10 TPST2 GGCX PROS1 TPST1 PROZ F2 GAS6 RPS23 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%8851680 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 CD209 BTN3A2 BTNL2 PPL XDH INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNA1 KPNB1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 95%5661231 Metallothioneins bind metals MT1G MT1H MT1X MT4 MT1B MT3 MT1E MT2A MT1A MT1M MT1F GSD IB%REACTOME DATABASE ID RELEASE 95%3229133 GSD Ib SLC37A4 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 95%9665244 Resistance of ERBB2 KD mutants to sapitinib ERBIN HSP90AA1 ERBB2 CDC37 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 95%76002 Platelet activation, signaling and aggregation TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 RASGRP2 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A RARRES2 IGF2 RAF1 RAB27B IGF1 PPBP RAPGEF3 CYRIB MANF RAPGEF4 SELP TF SCCPDH CALU MAGED2 PLA2G4A HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 ITPR1 CTSW ITPR2 ORM2 ITPR3 SERPINA4 TMSB4X PSAP ALB PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 TRPC7 ABCC4 AHSG ANXA5 F5 TRPC6 PLCG2 F8 TRPC3 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 STX4 CRK LEFTY2 LY6G6F LHFPL2 PCYOX1L CD9 FLNA FN1 F2RL2 F2RL3 LCP2 F2R LAT PRKCB RAC1 VAV3 PRKCQ P2RY12 P2RY1 VAV1 VAV2 MPL THPO ACTN1 GNA13 ADRA2C ADRA2B ADRA2A TBXA2R AKT1 GP1BB PRKCD PRKCA GP5 YWHAZ GP9 LYN PIK3CG PIK3R6 PIK3R5 GP6 CFL1 PF4 SOD1 AAMP MAPK14 PPIA TUBA4A PRKCG PRKCE GNG10 GNG12 GNG11 GNG13 GNB2 CFD GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TGFB1 GNGT2 GNA14 GNG3 GNA15 PDPN MPIG6B GNG2 CLEC1B GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 EGF PIK3CB PFN1 PRKCZ BCAR1 PCDH7 PDPK1 PIK3R3 PIK3CA ITGB3 ITGA2B SOS1 BRPF3 SPARC RAC2 SHC1 SERPINE1 RHOG PIK3R2 PIK3R1 GP1BA RHOA RHOB MAPK1 GNAT3 FCER1G MAPK3 PTPN1 TGFB2 PTPN11 TGFB3 CDC42 MGLL DGKG SRC ACTN2 DGKE DAGLA DGKD DGKB DGKA ABHD6 GNAI3 ABHD12 PRKCH GNAI1 DGKZ DGKQ GNAI2 DAGLB DGKK DGKI DGKH CALM1 CD36 VEGFB VEGFC VEGFD THBS1 VEGFA ALDOA GNA12 CSK FGB FGA VWF FGG APBB1IP TLN1 VCL PTPN6 SYK LCK FYN APP F13A1 POTEKP ISLR LAMP2 HABP4 PROS1 FAM3C CHID1 F2 PTK2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 95%3248023 Regulation by TREX1 TREX1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 95%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PAK2 PSMD3 PSMD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 95%397014 Muscle contraction KCNJ11 ABCC9 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 GUCY1A2 GUCY1A1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI MME ATP2B4 NPR1 ATP2B3 NPR2 ATP2B2 NPPC ATP2B1 CORIN TRPC1 CES1 SLC8A3 TTN ANXA1 PXN KCNK6 KCNK7 KCNK1 MYL12B CACNA2D2 MYL6 MYH11 CACNB2 NKX2-5 SCN11A SCN10A TMOD3 SCN1B SCN1A MYL9 KCNH2 SCN3B SCN3A KCNK10 GATA4 KCNK13 SCN2A KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 SCN9A KCNK9 SCN8A CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A ANXA2 KCNA5 SCN4A SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 TRIM72 PAK1 DYSF LMOD1 AHCYL1 MYL6B CACNA1H MYL12A MYLK CACNA1G CACNA1I ALDH2 PAK2 CALD1 ANXA6 MYL10 CAV3 TPM2 MYL11 TPM1 SORBS1 SORBS3 MYL5 MYL7 ITGA1 DMD SLN ATP1B3 ATP1B2 ATP1B1 PDE5A VIM ACTN3 KCNK12 KCNK15 FXYD4 MYL4 FXYD3 MYL1 MYL2 FXYD2 MYL3 DMPK FXYD1 MYBPC3 FXYD7 MYBPC1 FXYD6 MYBPC2 TNNC1 RYR1 TNNC2 RYR2 TNNT1 RYR3 TNNT2 TNNT3 TCAP CLIC2 TMOD1 TMOD4 TMOD2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 NEB FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 MYH3 MYH8 MYH6 ATP1A4 CACNG6 ATP1A3 CACNG7 TNNI1 ATP1A2 TNNI2 TNNI3 ATP1A1 KCNIP1 TPM4 KCNIP2 KCNIP4 TPM3 DES RANGRF PLN KCNIP3 FKBP1B ITGB5 CACNB1 CAMK2B CAMK2D ACTN2 CAMK2A TBX5 CACNG8 CALM1 CAMK2G CACNG4 KCNJ2 KCNJ4 KCNJ12 TLN1 VCL WWTR1 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB UBC RPS27A TCEA1 ERCC8 DDB1 XPA COPS7B COPS7A CUL4A COPS3 PPIE COPS6 COPS5 COPS8 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication ORC4 ORC6 H2BC9 ORC1 H2AZ2 ORC3 H4C9 ORC2 H2BC8 H2BC5 H2BC3 KPNA1 H2BC1 H2AC20 KPNB1 H2AX H2AB1 H2AC19 KPNA6 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ORC5 H3C15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT SOX17 XIAP SRY RNF146 SOX6 WNT5A SOX7 SOX4 WNT1 BCL9L RUVBL1 CTNNBIP1 FZD1 SOX13 RYK USP8 PYGO1 FZD8 BCL9 PYGO2 TLE4 TLE2 TLE1 CUL3 TNKS SMURF2 USP34 DPY30 WDR5 AXIN2 BTRC RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 KLHL12 LGR6 WNT3 LGR5 CCDC88C RSPO4 DACT1 LGR4 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 EP300 SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 PPP2R5E H3C15 FRAT2 FZD2 FZD5 H2BC9 FZD4 H2AZ2 H4C9 FZD6 PPP2R5B H2BC8 PPP2R5A H2BC5 PPP2R5D H2BC3 PPP2R5C H3-4 TCF7L2 H2BC1 TCF7L1 HDAC1 H2AC20 LEF1 TCF7 PIP5K1B CTNNB1 PPP2CA PPP2CB ASH2L MYC RSPO3 TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 APC YWHAZ PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 CSNK1G2 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 LEO1 WNT3A LRP5 PSMA7 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 KAT5 LRP6 PSMB4 DKK4 SFRP1 CTBP1 PSMB5 CSNK1E SFRP2 UBB WIF1 SOST PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A TERT ADRM1 MEN1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 WNT4 SMARCA4 PSMC1 CSNK2B PSMC2 TLE3 CHD8 CAV1 CBY1 SOX3 TRANSLATION%REACTOME%R-HSA-72766.7 Translation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 APEH HEMK2 MRPS18B MRPS18A ETF1 GSPT2 MRPS21 GSPT1 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 MRPL12 TUFM MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 RARS1 EIF2B5 MRPL30 EIF2B4 EIF2B3 MTRES1 LARS1 EIF2B2 MTRFR NDUFAB1 EIF2B1 AIMP1 AIMP2 RPS4Y2 QARS1 RPS27L RPS4Y1 RPS4X MARS1 RPS15 RPS14 DARS1 RPS17 SARS1 EEF1E1 RPS15A RPS16 RPS19 KARS1 RPS18 RPS3 IARS1 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPN2 ASCC2 RPN1 ASCC3 EIF2S2 EIF2S1 DDOST MT-CO1 EIF2S3 EPRS1 EIF4EBP1 EIF4E EIF4B TRMT112 EIF1AX UBE2D2 EIF4H PSMD8 UBE2D3 EIF3M PSMD6 EIF3K MT-CO2 EIF3L PSMD7 MT-CO3 ELOB EIF3I ELOC EIF3J PSMD2 RBX1 EIF3G EIF3H PSMD3 EIF3E CUL2 EIF3F PSMD1 EIF3C EIF3D EIF3A EIF3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 LTN1 NPLOC4 PSMD12 SEC61G PSMD11 RPLP0 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 SSR1 PSMC2 EIF4G1 SRPRA SRPRB MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 SEC61A2 SPCS3 SEC61A1 SPCS2 VCP SPCS1 SEC11A SEC11C MT-ATP6 MT-ATP8 MT-ND4L PARS2 EARS2 LARS2 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 EIF4A2 TCF25 SRP54 EIF4A1 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 MT-CYB SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 CARS2 VARS2 ANKZF1 KLHDC10 TSFM RPL4 EIF5B RPL5 MARS2 RPL30 DARS2 RPL3 EEF1G RPL32 SARS2 RPL31 NEMF RPLP1 EEF1D RPL34 MTRF1L RPL10L EEF1A1P5 RPL8 MTIF2 RPL10A MTIF3 RPL6 IARS2 RPL7 WARS1 RPL7A WARS2 RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 SRP14 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 RPL26L1 UBE2D1 SEM1 EEF2 MRPS17 MRPS15 MRPS16 MRPS14 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.5 Unblocking of NMDA receptors, glutamate binding and activation GRIA1 CAMK2B GRIA2 CAMK2D ACTN2 CAMK2A GRIN2C GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 GRIA3 CAMK2G GRIA4 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching ROBO2 SLIT1 NCK2 ROBO1 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 95%1483249 Inositol phosphate metabolism PLCB4 MTMR9 INPP5D MTMR7 PLCG1 PLD4 IPPK ISYNA1 IPMK OCRL INPP1 IP6K1 NUDT3 IP6K2 NUDT4 INPP5B SYNJ1 NUDT11 NUDT10 INPP5A IMPA1 PPIP5K1 PLCZ1 IMPA2 INPP4A PPIP5K2 INPP5J PLCE1 INPP4B IP6K3 MIOX ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity HMOX1 MAFK HM13 NFE2L2 BACH1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 95%111996 Ca-dependent events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%5663202 Diseases of signal transduction by growth factor receptors and second messengers JUN SEL1L FZD8 ERLIN2 NPM1 KLC1 MAMLD1 IHH DERL2 TRAK1 ERLEC1 OS9 KIF5B PRR5 GSK3A EML4 KRAS MAML2 MAML1 FGFR2 JUNB RAC1 MAML3 VAV1 MAPKAP1 DUSP6 DUSP7 GZMB DCTN1 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 MAPK8 BCL2L11 PAPSS1 BAD CD19 SQSTM1 AGK RBX1 POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F PIK3CG POLR2G POLR2H PIK3R6 POLR2I PIK3R5 POLR2J POLR2K POLR2L WDR48 GTF2F1 GTF2F2 IL10 PTPN12 MSN TYK2 KAT2B PIK3CD KAT2A ALK LMNA TP53 VCP TNKS FOXO4 FOXM1 CDK8 SMAD2 SMAD4 SMAD3 ESR1 JAG2 ADAM17 MDM2 ZMYM2 PTEN ARRB1 ARRB2 TPR HDAC5 RANBP2 FGFR3 HDAC8 HDAC9 HDAC6 HDAC7 TPM4 RNF43 TPM3 KLB FLT3 IRS1 PPP1CC PPP2R1B IRS2 PPP2R1A PIK3CB TNKS2 PPM1B FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 HDAC10 FGF9 HDAC11 AKT2 HRAS PDPK1 GAB1 FLT3LG TWIST1 FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 CARS1 PIK3R1 NRAS FGF20 PPFIBP1 MAPK1 EEF1G FGF23 CHUK FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 SNW1 CAMK2B ESR2 CAMK2D SRC NR4A1 CAMK2A NRG1 TFG MPRIP FGFR1OP2 ZAP70 SND1 ZC3HAV1 EIF2AK3 NOX4 CALM1 ATIC CAMK2G DUSP8 DUSP9 MRAS FAM114A2 KDR PORCN MCL1 CD86 QKI CD80 NF1 KIAA1549 ERBB2 DUSP10 CCNB1 HES1 ESRP1 TRAT1 BIRC6 RPS6KB2 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 PHB1 AGTRAP ARAF AP3B1 SHOC2 PEBP1 CSK AGGF1 JAK2 CPSF6 MARK3 TENT4A SPRED3 FGB BRAP SPRED2 SPRED1 FGA VWF MYO18A KSR1 LRRFIP1 KANK1 PPP1CB FGG RRBP1 BRAF ETV6 WDCP KSR2 GOLGA4 FAM131B BIN2 CNKSR2 STRN APBB1IP CNKSR1 NCBP1 TLN1 NCBP2 VCL FRS3 JAG1 LCK SEM1 IRF4 DLL1 FYN BCL2A1 SKP1 HGF CLIP1 CUL1 CLTC GCC2 NTRK3 NTF3 PDGFB NEURL1B HES5 MIB2 RAP1B MIB1 HEYL RAP1A NEURL1 RAF1 PRF1 ICOS STAT5A IL10RA ZC3HC1 FIP1L1 FN1 CUX1 TRIP11 RPS6 PDGFRA PRKAR1A MYH9 KIT NOTCH1 FZD5 FZD4 HBEGF FZD6 TCF7L2 CDKN1A HDAC1 CTNNB1 MET CEBPB RNF213 ATG7 SEC31A RBPJ TNRC6C MOV10 MLST8 AGO3 AGO4 MYC AGO1 AGO2 TSC2 PIM1 MTOR YWHAB FKBP1A PSMD8 PSMD6 PSMD7 PSMD2 AKT1S1 PSMD3 AKT1 PSMD1 PSMA5 PSMA6 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 PSMB5 UBB BCR PSMB2 PSMB3 LMO7 UBC PSMB1 RPS27A AKAP9 HEY1 HEY2 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CASP9 ERBIN CEP43 KDM7A TGFB1 RICTOR TGFBR1 TGFBR2 STAT1 CD28 IQGAP1 HSP90AA1 EGF CBL EGFR CDC37 PLCG1 RB1 CDKN1B MAP3K11 DUSP16 FGFR1 CLCN6 FOXO6 FOXO1 EP300 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 ITGA2B NRG2 STAT3 HDAC3 TBL1X NCOR2 NCOR1 TBL1XR1 HDAC4 HDAC2 PIK3AP1 AMER1 GSK3B CSNK1A1 AXIN1 APC STAT5B CCNC GRB2 HHAT SHH DHH CTBP2 CTBP1 DNMT1 CREBBP AREG BCL2L1 PTPN6 MAPK9 YES1 NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 EREG SYVN1 BTC EPGN AKT3 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 95%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ATF7IP PPHLN1 H2AC20 MPHOSPH8 H2AX ZCCHC8 EHMT2 EHMT1 H2AB1 TASOR MTREX H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B RBM7 H3C8 MORC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SETDB1 H3C15 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK10 MAPK8 FOS MAPK3 MAPK9 MAPK14 ATF2 MAPK11 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD ALOX15 ALOX5 LTA4H DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME DATABASE ID RELEASE 95%9616334 Defective Base Excision Repair Associated with NEIL1 NEIL1 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME%R-HSA-5619073.4 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement CFD C3 GZMM CFB IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 C2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 95%9860931 Response of endothelial cells to shear stress GNG13 ITGA5 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 PIK3R2 GNB3 ADCY4 NFKB1 ADCY3 GNB5 ADCY2 ADCY1 ABL1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB CHUK STAT1 PTPN1 IKBKB PPP2CA PECAM1 MLST8 GNG3 GNG2 GNG5 NFKBIA GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 IKBKE AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 IKBKG PPP2R1B ANXA2 PPP2R1A PIK3CB CALCRL ADM TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PTK2 PIK3CA P2RY2 ITGB3 ITGB1 MMP14 GNG12 ITGAV MAPKAP1 GNG11 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.2 Defective F8 binding to von Willebrand factor F8 VWF MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2A POLR2B BCDIN3D POLR2C XPO5 POLR2D AGO3 PRKRA POLR2E DROSHA RAN DICER1 AGO4 POLR2F TARBP2 POLR2G POLR2H AGO1 POLR2I AGO2 POLR2J POLR2K POLR2L DGCR8 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 95%192905 vRNP Assembly HSP90AA1 IPO5 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.4 Mitochondrial biogenesis RXRA CYCS SAMM50 HDAC3 MTX1 APOOL NR1D1 CHCHD3 DMAC2L TBL1X NCOA1 ESRRA PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 MT-ATP6 PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 MAPK12 HCFC1 CALM1 ATP5PF ATP5PD PPARGC1A ATP5PB NCOA2 PPARGC1B ATP5F1C NCOA6 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 NRF1 ATP5PO GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HSPA9 HELZ2 ATP5MC2 CREBBP CHD9 ATP5MC3 ALAS1 ATP5MK ATP5MJ MICOS13 MICOS10 CHCHD6 MTERF1 ATP5MG MAPK14 GABPA MED1 MAPK11 SIRT5 TGS1 ATP5MF PPRC1 MEF2D ATP5ME PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 ATP5F1A IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 MTX2 PPARA ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%399997 Acetylcholine regulates insulin secretion PRKCA CHRM3 GNA14 GNAQ MARCKS GNA15 PLCB3 PLCB1 PLCB2 GNA11 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.2 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%9022707 MECP2 regulates transcription factors MEF2C RBFOX1 PPARG RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693565.6 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks HERC2 H2BC9 KDM4B H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 ABL1 MAPK8 MDC1 KDM4A UBE2I SUMO1 SMARCA5 RNF168 NSD2 PIAS4 BRCC3 UBA52 BAZ1B BAP1 MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN UBB APBB1 BARD1 UBC EYA1 EYA2 H2BC26 EYA3 RPS27A EYA4 H2BC12L PPP5C H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 RAD50 UBXN1 H2BC12 H2BC13 H2BC14 H2BC15 TP53 H2BC11 ATM UBE2N MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 95%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 95%171319 Telomere Extension By Telomerase SHQ1 ACD DKC1 TINF2 TERF1 RUVBL2 TERF2 RUVBL1 TERT NHP2 ANKRD28 POT1 NOP10 TERF2IP WRAP53 PPP6C PPP6R3 RTEL1 CDK2 CCNA2 CCNA1 PIF1 GAR1 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 IKBKB RIPK1 CASP10 MAVS FADD RNF135 RIGI CHUK IFIH1 CASP8 TRIM25 TRIM4 IKBKG CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9833576 CDH11 homotypic and heterotypic interactions CDH24 CTNNB1 CDH11 JUP CTNND1 CDH8 CTNNA1 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.3 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN3 FCN1 MASP1 FCN2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway TALDO1 PGD DERA TKT RPIA PRPS2 PRPS1 RPEL1 RPE SHPK PGLS PRPS1L1 RBKS G6PD PGM2 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 95%5654736 Signaling by FGFR1 FLRT1 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 GIPC1 ANOS1 MAPK1 FLRT3 FGF23 FGF22 SPRED2 SPRED1 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FRS3 FGF3 RPS27A FGF4 FGF6 FGF9 TGFBR3 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis PSMA5 PSMA6 SEL1L PSMA3 CFTR PSMA4 PSMA1 PSMA2 ERLIN1 ERLIN2 UBA52 PSMD12 PSMD11 RNF185 PSMD14 PSMD13 PSMA7 PSMB6 VCP PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 DERL3 DERL1 UBC DERL2 PSMB1 RNF5 RPS27A ERLEC1 OS9 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 95%9657050 Defective OGG1 Localization MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 95%9694631 Maturation of nucleoprotein PRMT1 UBE2I SRPK1 SUMO1 PARP10 SRPK2 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 CSNK1A1 PARP14 PARP8 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 IKBKB RIPK1 UBC TICAM2 UBE2D1 TICAM1 RPS27A UBE2V1 LY96 TRAF6 UBA52 BIRC2 CD14 BIRC3 UBE2D2 UBE2D3 CHUK RIPK3 UBE2N IKBKG UBB TLR4 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 95%5635838 Activation of SMO EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON GRK2 IHH ARRB1 SHH DHH ARRB2 SMO KIF3A CSNK1A1 PTCH1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 95%9711123 Cellular response to chemical stress COX5B COX5A RELA NUDT2 PRDX3 NOX5 NQO1 GSTA3 COX6C GSTA1 ERO1A SESN1 SRXN1 CHD6 GPX3 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB COX6A1 BLVRA CCL2 ABCF2 COX6A2 TXNRD2 SOD3 CCS G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM ALB P4HB AQP8 CAT BTRC SOD2 CARM1 ATOX1 FBXL17 BACH1 PRKCI SLC7A11 MED1 NOTCH1 PRDX2 PRDX1 PTK6 CDKN1A CDKN2A SIN3A PRKAA2 MT-CO1 SQSTM1 ATF4 TKT MYC PSMD8 KEAP1 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 PSMD2 RBX1 PSMD3 AKT1 PSMD1 IDH1 PRKCD NCF1 PSMA5 NCF2 PSMA6 NCF4 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 NPLOC4 PSMD12 PSMD11 UBXN7 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CYBB PSMB4 CYBA DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 TALDO1 UBC PSMB1 RPS27A SOD1 ADRM1 CSNK2A1 PSMC5 GPX1 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PPARA CYCS MAFG PGD MUL1 CUL3 VCP PRDX6 NLRP3 TRIM21 GSTP1 HBA2 SESN2 HMOX2 GPX2 MAP1LC3B EGF SMARCD3 SKP2 TXNRD1 EP300 AKT2 STAP2 COX7A2L TXN RXRA STAT3 NFKB1 ABCG2 HBB HDAC3 COX4I1 COX4I2 TBL1X NCOA1 FABP1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 ABCC3 ABCC1 HM13 EIF2AK3 AMER1 NOX4 GSK3B NCOA2 NCOA6 ME1 TXN2 BRCA1 HELZ2 CREBBP SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 PALB2 TGS1 SEM1 COX7B SKP1 COX7C COX8A COX8C CUL1 AKT3 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 95%4839726 Chromatin organization RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 BCL11B SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 PHF10 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 BICRAL BRD7 BICRA BRD9 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 DPF1 HDAC2 DPF2 KAT8 DPF3 KDM5B SUZ12 KAT14 SETDB1 SS18L1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SS18 SMARCB1 BCL11A AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 KDM6A DNMT3A PBRM1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%196025 Formation of annular gap junctions CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 AP2M1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 95%75067 Processing of Capped Intronless Pre-mRNA CSTF2T CLP1 ZNF473 SNRPD3 FIP1L1 SNRPB PABPN1 CPSF4 SLBP CPSF7 CPSF1 CPSF3 NUDT21 CSTF3 CSTF2 CPSF2 CSTF1 PAPOLA SYMPK LSM10 NCBP1 LSM11 NCBP2 PCF11 SNRPG WDR33 SNRPE SNRPF TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 95%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation DHFR GCHFR GCH1 SPR NOS3 PTS HSP90AA1 PRKG2 AKT1 CALM1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion FES PLXNA2 PLXNA3 HSP90AA1 HSP90AB1 PAK1 PAK3 LIMK1 RAC1 FYN CFL1 PLXNA4 PAK2 NRP1 PLXNA1 SEMA3A CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.6 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex YWHAH YWHAZ WEE1 SFN CCNB1 CDC25C CDK1 YWHAB CHEK2 YWHAE CCNA2 CCNA1 YWHAQ CHEK1 YWHAG TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSENEN TIMP1 NCSTN APH1B PSEN2 TIMP2 PSEN1 TGFBR3 APH1A MMP14 MMP16 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP5 GP9 VWF GP1BA GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 FABP6 MGLL PLIN1 PPP1CA ABHD5 FABP12 PRKACG PRKACA LIPE PRKACB FABP9 PPP1CB FABP1 PPP1CC CAV1 FABP2 FABP3 PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 95%111995 phospho-PLA2 pathway MAPK1 PLA2G4A DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 95%5083627 Defective LARGE causes MDDGA6 and MDDGB6 LARGE1 B4GAT1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020958 Interleukin-21 signaling IL21R JAK3 STAT5A STAT5B STAT4 STAT3 JAK1 STAT1 IL2RG IL21 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 95%1614603 Cysteine formation from homocysteine CBS CTH COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 95%9864848 Complex IV assembly PET100 COX5B COX5A COA5 CMC1 SCO1 COX6C TACO1 SMIM20 COX4I1 COX4I2 SURF1 COX6A1 COX6A2 COX16 TIMM21 COX15 MT-CO1 COX18 COX6B2 HIGD1A COX6B1 COXFA4 COX7A2 COX7A1 COX11 COX19 COX17 COX14 RAB5IF COQ10B COQ10A TMEM177 COA3 SCO2 COA1 COX7A2L MT-CO2 COX7B MT-CO3 COX7C HIGD2A PET117 COX8A COX20 COX8C TMEM223 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM RTEL1 MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 95%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PIK3R1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 CD19 IGHV3-30 STIM1 IGHV3-33 ORAI2 IGKV1D-39 IGKV1D-33 ORAI1 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 CD22 TRPC1 IGKV2D-40 PIK3AP1 IGHV3-11 IGHV3-13 IGLV7-43 CALM1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 BTK IGLC3 BLNK IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 BLK IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 PIK3CD IGHV3-53 IGKV5-2 NCK1 IGLC6 IGKV1-5 PTPN6 SYK AHCYL1 FYN VAV1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes COL4A2 COL18A1 COL4A1 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB P4HA1 P4HA2 P4HA3 COL1A1 COL1A2 ADAMTS14 P3H2 P3H1 P3H3 SERPINH1 COL3A1 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 95%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2BC9 H2AZ2 H4C9 H2BC8 NCOA2 H2BC5 H2BC3 H2BC1 H2AC20 PKN1 KDM1A H2AX KLK3 KLK2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B KDM4C H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 AR KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 95%9664420 Killing mechanisms JUN RAC1 FZD7 DVL1 WNT5A DVL2 DVL3 MAPK8 NOXA1 NOXO1 CYBA NOX1 FASL CD95L SIGNALING%REACTOME DATABASE ID RELEASE 95%75157 FasL CD95L signaling CASP10 FAS CASP8 FASLG FADD SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4655427 SUMOylation of DNA methylation proteins DNMT1 BMI1 RING1 UBE2I SUMO1 RNF2 DNMT3B CBX8 PHC2 PHC1 DNMT3A CBX4 PCGF2 CBX2 PHC3 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FRS2 KLB PTPN11 FGF16 TRNA PROCESSING IN THE NUCLEUS%REACTOME%R-HSA-6784531.6 tRNA processing in the nucleus CLP1 POP5 POP7 POP1 RPP30 POP4 RTCB CPSF4 TSEN2 TSEN54 CPSF1 RPP38 CSTF2 RPP21 RPP25 DDX1 C2orf49 RPP40 TSEN15 ZBTB8OS TSEN34 NUP205 POM121 RPP14 NUP107 NUP188 RTRAF AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 XPOT NUP88 FAM98B NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ELAC2 TRNT1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME%R-HSA-901032.7 ER Quality Control Compartment (ERQC) UBC DERL2 SEL1L RNF5 RPS27A OS9 MAN1B1 UBA52 RNF185 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 EDEM2 AMFR SYVN1 RNF103 UBB TRIM13 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1 OXCT2 ACAT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%70263 Gluconeogenesis GPI ENO1 ENO2 ENO3 ENO4 G6PC1 TPI1 PGAM1 PC PGAM2 ALDOC ALDOB ALDOA GAPDH PCK2 PGK1 SLC37A1 PGK2 G6PC2 PCK1 G6PC3 FBP1 FBP2 SLC37A4 GAPDHS CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation SESN1 SESN2 SEC13 RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X RPS15 SAMTOR RPS14 SEH1L RPS17 NPRL2 NPRL3 RPS15A RPS16 GCN1 TCIRG1 RPS19 WDR59 RPS18 EIF2AK4 FLCN RPS3 MIOS RPS2 RPS11 ITFG2 IMPACT RPS10 DEPDC5 RPS13 KPTN RPS12 WDR24 RPS9 SH3BP4 RPS7 FNIP1 ATP6V1E1 RPS8 FNIP2 RPS5 KICS2 ATP6V1E2 RPS6 CASTOR1 RPSA CASTOR2 ATP6V1G1 RPS3A RPS26 ATP6V0B ATP6V0E1 ATP6V1G2 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ATP6V1B2 TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A RPL4 RPL5 ATP6V1H RPL30 RPL3 RPL32 ATP6V0E2 RPL31 ATP6V1G3 RPLP1 RPL34 ATP6V1D RPL10L RPL8 ATP6V1C1 RPL10A ATP6V1F CEBPB RPL6 ATP6V1C2 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPTOR RPL37 ATF3 ATF4 RPL39 RPL21 MLST8 RPL23 SLC38A9 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 MTOR RPL10 RPL12 RRAGA RPL11 RRAGC RPL36A RPL14 RHEB RPL13 RRAGB RPL15 RRAGD RPL18 RPL17 RPL19 LAMTOR2 RPL39L LAMTOR1 RPL41 LAMTOR4 RPL35A LAMTOR3 RPL23A LAMTOR5 RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism CHST2 B4GALT4 CHST3 B3GNT3 GNS ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 GALNS FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 HEXB HEXA B4GALT2 GLB1L3 B4GALT3 PRELP GLB1L2 CHST6 OMD KERA GLB1L B3GNT7 GLB1 B3GNT4 OGN CHST1 B3GNT2 CHST5 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 95%380284 Loss of proteins required for interphase microtubule organization from the centrosome CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway XIAP RACK1 TRAF1 TRAF2 MAP3K7 USP4 BIRC2 USP2 BIRC3 CYLD RBCK1 OTUD7B CHUK IKBKG IKBKB RIPK1 USP21 SHARPIN TNF OPTN TAB1 TRADD TAB3 TNFAIP3 TAB2 RNF31 SPATA2 TNFRSF1A OTUD1 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 95%6785807 Interleukin-4 and Interleukin-13 signaling CXCL8 TGFB1 CCL11 CCL2 STAT1 VCAM1 VIM CCL22 BCL6 IL6 TIMP1 RORC RORA NOS2 POU2F1 IL17F IL17A ANXA1 LBP LAMA5 HSP90AA1 FN1 S1PR1 JAK3 IL18 IL1A ITGAM IL1B ITGB2 LCN2 MMP1 MMP2 FGF2 TNFRSF1B FOXO1 IL6R JUNB SOCS3 SOX2 MAOA MMP3 TWIST1 HSP90B1 ITGB1 IL23R IL13RA2 IGHG4 IL13RA1 IGHG1 IL4R STAT3 IL23A FSCN1 PIK3R1 CDKN1A NDN LIF RHOU NANOG ALOX15 IGHE ITGAX OPRD1 OSM BATF CCND1 BIRC5 FASLG SOCS1 FCER2 MYC PTGS2 PIM1 ALOX5 HMOX1 AKT1 HIF1A OPRM1 CD36 MCL1 GATA3 VEGFA POMC COL1A2 IL4 JAK2 MUC1 IL12B IL12A IL13 JAK1 IL2RG IL10 MMP9 SOCS5 BCL2 TYK2 TNF BCL2L1 HSPA8 ICAM1 ZEB1 CEBPD IRF4 STAT6 F13A1 SAA1 TP53 FOS FOXO3 HGF SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 95%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 95%187706 Signalling to p38 via RIT and RIN NTRK1 RIT1 NGF RIT2 BRAF VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%168325 Viral Messenger RNA Synthesis NUP85 TPR NUP62 POLR2A POLR2B NUP88 POLR2C NUP43 POLR2D RAE1 POLR2E POLR2F NDC1 POLR2G RANBP2 POLR2H SEC13 POLR2I NUP155 POLR2J NUP133 POLR2K NUP210 POLR2L NUP153 NUP93 NUP50 NUP35 NUP54 GTF2F1 GTF2F2 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 95%8957322 Metabolism of steroids GGPS1 CYP51A1 SRD5A3 LSS SREBF2 SQLE MTF1 DHCR7 SLCO1B1 SLCO1B3 LDLRAP1 CUBN ACACB GPAM STS SLC51A SLC51B CYP27A1 SAR1B CYP39A1 PLPP6 LHB ABCB11 SEC23A MBTPS1 SCAP VDR ALB SLC10A1 MBTPS2 SLC10A2 STAR AKR1B15 SEC24B SEC24A AKR1B1 ARV1 CYP17A1 SMARCD3 STARD3NL SEC24D CYP7B1 SEC24C AKR1D1 CARM1 KPNB1 HSD17B7 CYP7A1 HSD17B1 HSD17B2 HSD17B3 HSD17B12 AKR1C1 NSDHL AKR1C2 ACACA FDXR MED1 AKR1C4 STARD3 STARD4 CYP8B1 STARD5 STARD6 MSMO1 CH25H CYP46A1 FDX1 ELOVL6 FDX2 RXRA SCD FASN CGA SLC27A2 HSD11B1 HSD11B2 IDI2 NFYA EBP NFYB CYP11A1 NFYC TBL1X LGMN NCOA1 ACOT8 CYP11B2 SERPINA6 CYP27B1 TSPO CYP24A1 CYP2R1 CYP21A2 TBL1XR1 FABP6 SUMO2 ABCC3 UBE2I GC NR1H4 HSD3B7 OSBP HSD3B2 PIAS4 HSD3B1 AMACR NCOA2 SLC27A5 NCOA6 RAN INSIG2 INSIG1 CYP19A1 POMC ACAT2 MVD OSBPL9 LBR OSBPL7 OSBPL6 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 BAAT HELZ2 ACOX2 CREBBP CYP11B1 SLCO1A2 SP1 CHD9 OSBPL1A TGS1 AKR1C3 HSD17B4 HSD17B14 IDI1 LRP2 MVK TM7SF2 HSD17B11 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 PPARA TSPOAP1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S DISEASES OF NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%9735804 Diseases of nucleotide metabolism APRT PNP HPRT1 ADA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF SFTPA2 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 95%4791275 Signaling by WNT in cancer APC FZD5 FZD4 PORCN FZD6 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 FZD8 WNT3A LRP5 RNF43 KREMEN1 CTNNB1 KREMEN2 DKK1 TNKS DKK2 LRP6 CTBP2 DKK4 CTBP1 PPP2R1B PPP2R1A TNKS2 PPP2CA PPP2CB AMER1 GSK3B CSNK1A1 PPP2R5E AXIN1 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation CYB5B HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NMT2 AKT1 ZDHHC21 CALM1 CAV1 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 95%209822 Glycoprotein hormones CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 95%182971 EGFR downregulation HBEGF SH3KBP1 EGF ARHGEF7 CBL EGFR UBA52 STAM STAM2 HGS PTPRK EPS15L1 PTPN12 EPN1 UBB SPRY1 PTPN3 CDC42 UBC RPS27A SH3GL3 AREG EPS15 SH3GL2 SH3GL1 SPRY2 TGFA EREG BTC EPGN COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 95%6799198 Complex I biogenesis MT-ND6 MT-ND4 NDUFC2 MT-ND5 NDUFC1 MT-ND2 MT-ND3 NDUFS8 MT-ND1 NDUFS7 NDUFS6 PYURF NDUFS5 NDUFS4 NDUFS2 TMEM126A NDUFS1 TMEM126B NDUFB9 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFAF8 FOXRED1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFA9 NDUFA8 NDUFAF2 NDUFA7 SFXN4 NDUFA6 NDUFAF3 NDUFAF1 NDUFA3 NDUFA2 NDUFA1 TMEM186 ACAD9 OXA1L DMAC1 DMAC2 NDUFS3 TIMMDC1 NUBPL LYRM2 HSCB NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 ECSIT NDUFB10 HSPA9 NDUFB11 NDUFV3 NDUFV2 NDUFB8 NDUFV1 COA1 NDUFA5 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 95%166187 Mitochondrial Uncoupling SLC25A14 UCP1 SLC25A4 PM20D1 UCP3 SLC25A27 UCP2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 95%2644605 FBXW7 Mutants and NOTCH1 in Cancer SKP1 RBX1 NOTCH1 CUL1 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TIAM1 ERBIN ARHGAP26 MPP7 VANGL1 RAC2 ARHGAP32 ABI2 TAOK3 PIK3R2 PIK3R1 ABI1 ESYT1 SAMM50 MTX1 ABR MCF2 PLD2 CDC42 DOCK4 ANKLE2 DOCK3 ARHGDIA LAMTOR1 CYFIP1 DOCK2 NCKAP1 DOCK1 NCF1 IQGAP1 TFRC NCF2 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 EMD LBR GIT1 TMPO SWAP70 ARMCX3 CYBB CYBA VRK2 LEMD3 BCR DEPDC1B CDC42EP1 DSG2 VAMP3 RAB7A CDC42EP4 EPHA2 GARRE1 TRIO ARHGAP17 ARHGAP21 PREX1 LMAN1 PAK1 PGRMC2 RACGAP1 VAV3 NHS SLITRK5 DEF6 VAPB NCKAP1L PAK2 WASF2 PIK3CA PIK3R3 PAK4 DIAPH3 ITGB1 VAV1 GIT2 VAV2 CAV1 MCAM TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 INS PLK2 NPAS4 MAPK1 ARNT2 REST BMAL1 SRF NR3C1 MAPK3 CDK5R1 RET KCNIP3 CREBBP GEM ARNT TNRC6C MOV10 NAMPT CDK5 AGO3 AGO4 RBFOX3 AGO1 AGO2 MDM2 TNRC6A TNRC6B IQSEC3 BDNF XPO1 FOS SYT10 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME%R-HSA-5083636.4 Defective GALNT12 causes CRCS1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B GALNT12 MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.7 Cytosolic sulfonation of small molecules PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 SULT1C4 SULT2A1 SULT1A3 TPST2 TPST1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9018519 Estrogen-dependent gene expression JUN ZNF217 EBAG9 KDM4B YY1 DDX5 GPAM CXCL12 ESR1 POU2F1 TBP HSP90AA1 CARM1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 H3-3B H3C8 MED1 H2AC8 H2AC6 CTSD H2AC7 H2BC17 GTF2A1 RUNX1 SMC1A GTF2A2 SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 CBFB H3C15 CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 HSP90AB1 KDM1A CCND1 PTGES3 NRIP1 FKBP4 NCOA1 ATF2 KCTD6 JUND TNRC6C MOV10 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B AXIN1 POLR2A POLR2B GATA3 NCOA2 POLR2C POLR2D POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K NR5A2 POLR2L GTF2F1 GTF2F2 CCNT1 KAT5 KANK1 CREBBP SP1 BCL2 CDK9 KAT2B FOXA1 TLE3 KPNA2 TGFA USF1 FOS GREB1 CHD1 PGR TFF3 TFF1 CXXC5 USF2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJA1 GJB2 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 95%168273 Influenza Viral RNA Transcription and Replication NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 2-LTR CIRCLE FORMATION%REACTOME DATABASE ID RELEASE 95%164843 2-LTR circle formation BANF1 XRCC6 XRCC4 XRCC5 LIG4 PSIP1 HMGA1 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation PARS2 YARS2 KARS1 EARS2 LARS2 PPA2 NARS2 RARS2 TARS2 AARS2 CARS2 VARS2 HARS2 MARS2 DARS2 SARS2 FARS2 IARS2 QARS1 WARS2 GARS1 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 95%8875791 MET activates STAT3 MET STAT3 HGF VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 95%5660686 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 95%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 STAT5A STAT5B BCL2L1 CDKN1A PIK3R1 GRB2 NRAS PIM1 HRAS GAB2 PIK3CA FLT3 NOX4 PTPN11 DIGESTION%REACTOME DATABASE ID RELEASE 95%8935690 Digestion ALPI MGAM PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B SI AMY1C CLPS LCT GUCA2B CEL GUCA2A CHIT1 LIPF PNLIP PIR PNLIPRP3 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 95%983231 Factors involved in megakaryocyte development and platelet production KIF28P IFNA2 IFNA8 MAFG IFNA13 IFNA14 IFNA16 IFNA17 KIF5C ABL1 MFN1 KIF21A MFN2 KIF21B KIFAP3 KLC1 KLC4 IFNA10 KLC3 KLC2 PRKACG IFNA21 PRKACA IFNB1 PRKACB KIF16B KIF3A KIF20B WEE1 KIF3B KIF3C KIF5B CDK5 KIF5A KIF18B KIF4B KIF4A KIF12 PHF21A KIF11 DOCK11 KIF15 KIF19 KIF13B VPS45 KIF1C KIF1B KIF1A KIF25 KIF22 RCOR1 KIF6 KIF27 SH2B2 KIF9 KIFC2 KIFC1 HMG20B DOCK6 DOCK9 CABLES1 DOCK8 DOCK7 RAB5A CAPZB MYB KIF26A KIF26B GATA6 H3-3B H3C8 PRKAR1B PRKAR2B KIF23 PRKAR1A RAC1 PRKAR2A ZFPM1 RBSN KIF20A KIF18A GATA2 H3C15 IRF1 IRF2 NFE2 HDAC1 HBB KDM1A KIF2A SIN3A CDK2 KIF2C KIF2B CAPZA2 CDC42 ITPK1 DOCK5 HDAC2 CENPE DOCK4 DOCK3 CBX5 SH2B3 GATA4 JMJD1C HBE1 GATA1 DOCK2 ZFPM2 DOCK1 GATA5 AK3 MICAL1 CARMIL1 HBG2 GATA3 HBG1 EHD1 EHD2 EHD3 MAFF HBD DOCK10 AKAP10 AKAP1 SH2B1 CABLES2 JAK2 MAFK CAPZA1 RAD51B RACGAP1 RAD51C TP53 IFNA5 IFNA4 IFNA7 IFNA6 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.2 Lysosomal oligosaccharide catabolism MAN2C1 MANBA MAN2B1 MAN2B2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 95%5632928 Defective Mismatch Repair Associated With MSH2 MSH6 MSH2 MSH3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655332 Signaling by FGFR3 in disease FGF18 SOS1 FGF1 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGFR3 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA FGF16 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.6 Diseases of hemostasis GP5 GP9 SERPING1 KLKB1 GP1BA ADAMTS13 F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin SMAD2 SMAD4 SMAD3 TGFBR3 MAPK1 FST FOXH1 ACVR1B FSTL3 ACVR2B ACVR2A INHBB DRAP1 INHBA ACVR1C INHA MAPK3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.2 RUNX1 regulates transcription of genes involved in differentiation of HSCs YAP1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ABL1 H2AC20 ITCH LMO1 LMO2 PSMD8 PSMD6 TCF3 PSMD7 TCF12 LDB1 PSMD2 PSMD3 PSMD1 GATA1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 GATA3 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CDK7 PSMB4 MNAT1 PSMB5 H2AX UBB PSMB2 SPI1 PSMB3 H2AB1 UBC H2AC19 PSMB1 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 MYB H3-3B ADRM1 H3C8 H2AC8 H2AC6 PSMC5 H2AC7 PSMC6 H2BC17 SEM1 PSMC3 RUNX1 PSMC4 H2BC12 PSMC1 H2BC13 PSMC2 H2BC14 TP73 H2AJ H2BC15 TAL1 H2BC11 KMT2A CBFB GATA2 H3C15 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR6 HTR1D HTR1A HTR7 HTR1B HTR5A HTR2B HTR2C HTR1E HTR2A HTR1F HTR4 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NTRK1 SOS1 MAPKAPK3 SHC1 NGF MAPKAPK2 NRAS MAPK14 MAPK11 RALA SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME%R-HSA-168138.6 Toll Like Receptor 9 (TLR9) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 EEA1 TASL HMGB1 RBSN CASP8 IRF5 MAP2K1 UBE2N TLR9 PIK3C3 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 PIK3R4 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A13 SLC25A18 SLC17A8 SLC6A1 SLC6A5 SLC22A2 SLC22A1 SLC6A4 SLC6A7 SLC6A19 SLC6A2 SLC6A15 SLC6A11 SLC6A3 SLC6A14 SLC6A9 SLC17A6 SLC6A20 SLC17A7 SLC25A22 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 95%5579026 Defective CYP11A1 causes AICSR CYP11A1 FDX1 FDX2 FDXR RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8952158 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD4 SMAD3 BCL2L11 FOXO3 ANCHORING FIBRIL FORMATION%REACTOME%R-HSA-2214320.5 Anchoring fibril formation TLL2 TLL1 LAMB3 COL7A1 LAMA3 LAMC2 BMP1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L POLI UBB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 95%176407 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC14A CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 CDC20 ANAPC15 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811434 COPI-dependent Golgi-to-ER retrograde traffic KIF28P KDELR1 KDELR3 SURF4 KIF5C KIF21A KIF21B KIFAP3 KLC1 KIF2A KLC4 KLC3 KLC2 NSF KIF2C KIF2B RINT1 ARF3 KIF16B KDELR2 KIF3A KIF20B COPB2 COPA TMED10 SEC22B KIF3B TMED2 KIF3C KIF5B KIF5A KIF18B KIF4B KIF4A COPE KIF12 CENPE ARF4 KIF11 USE1 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 COPB1 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 ARF1 ARF5 NAPA GBF1 NAPB NBAS RAB1A STX18 RAB1B NAPG BNIP1 ARFGAP3 ARFGAP2 ARCN1 ZW10 KIF26A KIF26B COPG2 COPG1 KIF23 RACGAP1 KIF20A KIF18A ARFGAP1 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 95%194441 Non-coding RNA Metabolism SNRPD2 SNRPD1 SNRPD3 PRMT5 SNRPB CLNS1A SNUPN WDR77 SMN2 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C GEMIN2 NUP42 NUP85 GEMIN4 TPR NUP62 GEMIN5 GEMIN6 GEMIN7 NUP88 GEMIN8 NUP43 RAE1 DDX20 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NCBP1 NCBP2 TGS1 SNRPG PHAX SNRPE SNRPF HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection H2AC1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 RBBP4 DAXX NUP37 RBBP7 PML H2AC19 DYNC1LI1 H2BC26 H2AC14 DYNC1LI2 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 H2BC17 CHMP2B VPS4A CHMP2A H2BC12 MVB12B H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 ITGB1 H3C15 H2BC9 H4C9 CHMP3 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 HNRNPK SUZ12 H2AC17 H2AC12 NUP214 TRIM28 H2AC25 H2AC21 EZH2 VPS36 VPS25 CBX1 SNF8 CHMP1A CEBPD ELK1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8939256 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 ESR1 CBFB RSPO3 FOXP3 AXIN1 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 NAT2 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PPP2R5C USP7 UBA52 CDKN2A RNF34 USP2 SGK1 CDK1 RICTOR CCNG1 CDK2 DAXX PRDM1 RFFL UBB PPP2R1B PPP2R1A PHF20 PPP2CA PPP2CB UBC MLST8 RPS27A AKT2 MDM2 MDM4 CHEK2 MTOR PRR5 PDPK1 CCNA2 TP53 CCNA1 ATM AKT1 MAPKAP1 AKT3 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM PNP ITPA NT5E NT5C NT5C1A XDH MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades JUN PDGFB RASGRP1 RAP1B RAP1A PRKACG RAF1 PRKACA PRKACB PRKG2 IL2 IL3 IL6 CDC14A FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA RAC1 KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 KALRN DNAJB1 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB SHC2 HSPB1 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 XPO1 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PAK1 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP SEPTIN7 PAK2 CDC14B ARL2 RAG2 RAG1 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A ETV4 RASA3 RASA4 RASA2 ABHD17C IGF2BP1 MAPK6 MAPK4 ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR CCND3 FNTB MAP3K11 MAPKAPK5 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 CDC42EP5 FGF3 CDC42EP3 FGF4 CDC42EP2 FGF6 FOXO1 FGF7 FGF9 IL6R RASA1 PAK3 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 CDC42 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 NCOA3 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA FOXO3 PTK2 HGF EREG BTC EPGN UB-SPECIFIC PROCESSING PROTEASES%REACTOME DATABASE ID RELEASE 95%5689880 Ub-specific processing proteases USP17L1 RNF146 TOMM20 RUVBL1 MAP3K7 USP8 USP7 USP5 USP4 USP3 IL33 USP2 MUL1 H2AC1 TGFBR1 CDC25A FKBP8 STAM2 TNKS ADRB2 FOXO4 ATXN7 RIPK1 SUDS3 USP11 CLSPN SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 SMAD7 NFKBIA TADA3 MDM2 MDM4 TAB1 RIGI USP37 USP33 USP34 PTEN ARRB1 ARRB2 POLB USP30 USP47 USP48 USP49 USP42 USP44 TRAF2 AXIN2 H2BC18 TRAF6 BIRC2 OTUB1 BIRC3 USP13 USP14 BECN1 USP15 USP16 SKP2 USP10 USP12 HGS MAT2B CDC20 USP18 USP19 TNKS2 USP24 IDE USP25 H2AC19 USP26 H2BC26 USP20 H2AC14 USP21 USP22 H2BC21 TAF10 USP28 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H2BC9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MYC TRRAP CCP110 PSMD8 KEAP1 PSMD6 H2AC17 H2AC12 PSMD7 USP17L4 USP17L5 PSMD2 USP17L8 PSMD3 PSMD1 USP17L30 HIF1A RNF123 AR AXIN1 RNF128 VDAC3 VDAC2 PSMA5 VDAC1 PSMA6 CFTR PSMA3 GATA3 PSMA4 PSMA1 SNX3 RHOT1 PSMA2 RCE1 UBA52 SIAH2 PSMD12 PSMD11 TADA2B CYLD PSMD14 H2AC25 H2AC21 PSMD13 WDR48 PSMA7 PSMB6 IFIH1 PSMB7 PSMB4 UFD1 PSMB5 IKBKG UBB TOMM70 PSMB2 PSMB3 UBC PSMB1 DDB2 RPS27A KAT2A PTRH2 WDR20 ADRM1 USP17L21 USP17L20 USP17L22 PSMC5 PSMC6 SEM1 PSMC3 TAF9B PSMC4 USP17L15 PSMC1 PSMC2 USP17L18 USP17L17 TP53 CCNA2 USP9X CCNA1 USP17L19 USP17L10 USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 POU5F1 NANOG INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels GNG13 GNB2 KCNJ2 KCNJ8 KCNJ3 KCNJ11 GNB1 KCNJ4 ABCC8 ABCC9 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 KCNJ1 KCNJ14 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression PTK6 PELP1 EPAS1 NR3C1 HIF1A RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism GUSB CD44 ABCC5 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HAS1 HYAL2 HEXB HAS3 HEXA CHP1 HAS2 SPAM1 HYAL1 HYAL3 HYAL4 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 95%9830674 Formation of the ureteric bud ROBO2 GFRA1 EYA1 BMP4 SLIT2 FOXC2 ITGA8 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 WNT11 ITGB1 GREM1 SALL1 SIX2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963693 Aspartate and asparagine metabolism FOLH1 FOLH1B GOT1 ASPG NAALAD2 NAT8L ASPA SLC25A12 GOT2 ASNS SLC25A13 GADL1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOX2 HSD17B4 AMACR ACOX3 ACOXL CROT CRAT ACOT8 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism SLC26A2 CSPG4 CHST3 CHST14 HSPG2 PAPSS2 SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B3GALT6 B4GALT1 B4GALT7 GPC1 GPC3 GPC2 ST3GAL3 GPC5 GPC4 NCAN GPC6 HEXB CHSY1 HEXA BGN DCN PRELP CHST6 BCAN OMD EXT1 VCAN KERA SDC1 OGN CSPG5 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A4 TOMT BCHE SLC6A3 ALDH2 COMT ACHE SLC22A2 SLC22A1 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization PLK1 GORASP2 GORASP1 USO1 CCNB1 RAB2A CDK1 MAPK1 RAB1A RAB1B GOLGA2 CCNB2 BLZF1 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 95%9018682 Biosynthesis of maresins CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 EPHX2 ALOX5 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 95%9634635 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 NRAS PRKCZ SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 95%9694516 SARS-CoV-2 Infection IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 DDX5 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ ACE2 VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 HAVCR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 PARP10 PARP6 SFTPD IL17RC GSK3A PARP4 IL17RA PARP16 NLRP12 YWHAQ PARP9 IL17F PARP14 IL17A YWHAG PARP8 GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C RPS10 STAT2 CHMP4B RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CHMP2B RPS3A RPS26 CHMP2A RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N CHMP3 CHMP6 HLA-H CHMP7 RPN2 HLA-B ZDHHC20 HLA-C TUSC3 ATG14 PRKCSH HLA-F RPN1 ZDHHC5 HLA-G HSP90AB1 HLA-E MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 SDC2 DDOST SDC3 MGAT4C ZDHHC9 IKBKB TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 UBE2I GPC2 GPC5 SUMO1 GPC4 YWHAB GPC6 TRIM25 SDC1 IKBKE AKT1 IRF7 VHL NUP214 SFN YWHAZ ISCU UBA52 IFIH1 JAK1 TRIM4 IKBKG TOMM70 UBB RIPK2 UBC TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 FURIN VCP STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C ANO8 ANO9 NUP42 NUP85 ANO6 ANO7 TPR ANO4 NUP62 ANO5 UVRAG NUP88 MAP1LC3B ANO2 ANO3 NUP43 RAE1 HSP90AA1 ANO1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 TMPRSS2 NOD1 SRPK2 ANO10 GALNT1 NOD2 AKT2 PDPK1 NRP1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 PRMT1 SRPK1 HSPG2 TJP1 CHUK PTPN11 AGRN ST6GALNAC2 SIKE1 GSK3B ST6GAL1 CSNK1A1 ST6GALNAC3 ST6GALNAC4 CREBBP ST3GAL4 ST3GAL1 ZCRB1 PTPN6 ST3GAL2 ST3GAL3 IRAK2 SNRPG TAB3 TAB2 SNRPE CTSL IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.3 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 95%9006931 Signaling by Nuclear Receptors JUN ZNF217 EBAG9 DDX5 RXRG GPAM CXCL12 POU2F1 NOS3 TBP S1PR3 CARM1 MMP2 MED1 GTF2A1 GTF2A2 MMP3 SCD FASN HBEGF HDAC1 HSP90AB1 PTGES3 CCND1 FKBP4 ATF2 RARG JUND CYP26A1 CYP26B1 TNRC6C MOV10 CYP26C1 AGO3 AGO4 FOSB MYC AGO1 AGO2 TNRC6A TNRC6B XPO1 RARB AKT1 POLR2A POLR2B GATA3 POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 KAT2B KPNA2 GNG10 IGF1R PGR GNG12 CAV1 GNG11 GNG13 FKBP5 GNB2 PPARD KDM4B YY1 GNB1 DHRS4 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GNG3 ESR1 GNG2 GNG5 RDH5 GNG4 GNG7 GNG8 HSP90AA1 EGF EGFR CDKN1B H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MYB EP300 AKT2 H3-3B H3C8 PRKCZ H2AC8 CTSD H2AC6 H2AC7 HRAS H2BC17 RUNX1 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 PDPK1 H2BC15 STAG2 H2BC11 RAD21 RARA PIK3R3 PIK3CA CBFB H3C15 RXRA CITED1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 PRMT1 NRAS H2AC20 CETP KDM3A HDAC3 KDM1A MAPK1 GNAT3 KDM1B GPS2 RXRB NRIP1 APOD UGT1A3 APOE TBL1X PCK1 NCOA1 SRF ABCA1 MAPK3 ABCG8 KDM4A MYLIP ABCG5 NR1H2 FABP5 KCTD6 APOC4 NR1H3 NCOR2 ARL4C EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ESR2 ABCG1 SRC PDK4 GNAI3 GNAI1 GNAI2 CALM1 AXIN1 NCOA2 NCOA3 PDHB NR5A2 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 CCNT1 KAT5 KANK1 MMP9 STRN CREBBP SP1 BCL2 CDK9 PPP5C AREG ADH1C CRABP2 ADH1A CRABP1 SDR16C5 ADH4 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 FOXA1 ALDH1A3 ZDHHC7 DHRS9 TLE3 ALDH1A2 TGFA PPID ALDH1A1 USF1 FOS CAV2 ALDH8A1 GREB1 FOXO3 ELK1 CHD1 PTK2 MMP7 EREG TFF3 UHMK1 TFF1 BTC ZDHHC21 EPGN CXXC5 AKT3 DLD USF2 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.3 Eicosanoid ligand-binding receptors LTB4R2 OXER1 PTGER4 GPR17 PTGFR PTGER1 LTB4R TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR CYSLTR1 CYSLTR2 PTGIR C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) RELA MAP3K7 UBA3 UBE2M PRKACG RAF1 PRKACA PRKACB CD209 CARD11 MALT1 ITPR1 RELB CLEC10A ITPR2 CLEC7A CLEC4A ITPR3 NFKBIA CARD9 CLEC4E MAP3K14 CLEC6A TAB1 PLCG2 PYCARD CLEC4C CLEC4D TRAF6 BTRC IL1B EP300 PAK3 HRAS PPP3CA PPP3CB PDPK1 CASP8 PPP3R1 UBE2N NFATC1 MUC13 NFKB1 NRAS CDC34 NFATC2 CHUK FCER1G IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 MUC12 PRKCD MUC15 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 MUCL1 PSMA1 MUC3A LYN MUC5AC PSMA2 MUC3B UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 NFATC3 NFKB2 PSMA7 MUC1 PSMB6 MUC2 PSMB7 PSMB4 MUC7 MUC4 PSMB5 MUC6 MUC16 IKBKG UBB MUC17 PSMB2 PSMB3 CREBBP MUC19 UBC PSMB1 MUC5B MUC20 MUC21 RPS27A ICAM2 ICAM3 FBXW11 UBE2V1 ADRM1 PSMC5 SYK PAK1 PSMC6 SEM1 PSMC3 AHCYL1 FYN PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 PAK2 RPS6KA5 CUL1 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A EIF4G1 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 95%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta IFNA2 OTUD5 IFNA8 ATG5 ATG12 RELA IFNA13 IFNA14 IFNA16 IFNA17 NFKB1 HSP90AB1 UBE2K ITCH IFNA10 PIN1 IFNA21 IFNB1 CHUK ISG15 PCBP2 IKBKB RIPK1 TBK1 IRF3 NFKBIA MAVS DHX58 RNF125 TKFC TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 TRIM25 IKBKE IRF7 SIKE1 TANK TRAF2 UBE2D1 HSP90AA1 TRAF3 TRAF6 UBA52 FADD CYLD NFKB2 IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG TOMM70 UBB CREBBP UBC RPS27A CASP10 NLRX1 EP300 NLRC5 UBA7 AGER RNF135 S100A12 MAP3K1 APP S100B SAA1 HMGB1 NFKBIB CASP8 UBE2L6 IFNA5 HERC5 IFNA4 IFNA7 IFNA6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling LIFR RUNX1 ELF1 CBFB IL3 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209905 Catecholamine biosynthesis PNMT DDC TH DBH DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts RXRA SLCO1A2 ABCB11 NCOA2 SLCO1B1 SLC27A5 FABP6 SLCO1B3 ABCC3 ALB SLC10A1 SLC10A2 STARD5 NR1H4 SLC51A NCOA1 SLC51B BAAT DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 95%5610783 Degradation of GLI2 by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI2 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors TNFSF18 TNFSF14 TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF18 TNFRSF1B TNFSF13 TNFRSF14 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells YAP1 ITGA5 GNAQ RELA NFKB1 ABL1 CHUK CAPNS1 CAPNS2 CAPN2 STAT1 PTPN1 IKBKG PPP2R1B ANXA2 PPP2R1A IKBKB PPP2CA PPP2R2A VCL PIEZO1 NFKBIA GNA11 IKBKE PTK2 ITGB3 ITGB1 ITGAV DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 95%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 95%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A NFE2L2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.2 Regulated proteolysis of p75NTR PSENEN NCSTN APH1B PSEN2 PSEN1 RELA NGFR NFKB1 ADAM17 TRAF6 APH1A SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 95%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 95%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 RELA PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 95%165054 Rev-mediated nuclear export of HIV RNA NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 MAPK1 GNA13 GNGT2 F2RL2 GNA12 F2RL3 MAPK3 F2R GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 ARRB1 ARRB2 GNG10 F2 GNG12 GNG11 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RBM8A ETF1 GSPT2 GSPT1 UPF3A SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 UPF2 UPF1 PNRC2 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 PPP2R1A RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 PPP2CA RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 CASC3 NCBP1 NCBP2 PPP2R2A RPS27A DCP1A EIF4G1 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling ERBIN STUB1 HBEGF HSP90AA1 ERBB2 EGF USP8 EGFR CDC37 UBA52 MATK PTPN18 PTPN12 UBB UBC RPS27A RNF41 CUL5 AKT2 NRG1 AKT1 EREG NRG3 NRG4 NRG2 BTC AKT3 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 95%9006934 Signaling by Receptor Tyrosine Kinases YAP1 ITCH PRDM1 ITPR1 ITPR2 ITPR3 NOS3 PRR5 CHD4 NTRK1 KIDINS220 CRK REST HGS VGF JUNB PRKCB RAC1 VAV3 CRKL VAV1 VAV2 MAPKAP1 TIAM1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ARHGEF7 MAPK7 APH1A PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 SOCS1 MDK WWOX ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 HIF1A FES POLR2A POLR2B POLR2C POLR2D LYN POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K STAM POLR2L RALA WWP1 GTF2F1 GTF2F2 RAB4A PTPN18 PTPN12 PTPN2 AAMP MKNK1 SPRY2 ALK AHCYL1 PRKCE PGR MST1 MEF2A MST1R RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 USP8 STAM2 SPHK1 CDK5 ESR1 ADAM17 CYFIP2 PTPRU SH2B2 CMA1 FER TEC GRAP RAB4B KLB FLT3 IRS1 PPP2R1B PDE3B IRS2 PPP2R1A PIK3CB TCIRG1 IDE FGF1 FGF2 FGF3 NCK2 PTPRF FGF4 FGF6 NCK1 FGF7 FGF9 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 PDPK1 GAB1 FLT3LG FRS2 DIAPH1 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 ITGB1 TLR9 PIK3C3 TRIB3 ATP6V0D1 SOS1 ATP6V0C ATP6V0D2 GFAP ATP6V1B1 ATP6V1A SHC1 PPP2R5D PIK3R4 PIK3R2 PIK3R1 INS NRAS ATP6V0A2 SGK1 FGF20 THEM4 RHOA ATP6V1H PTPRJ MAPK1 ATP6V0A4 ATP6V0E2 ATP6V1G3 FGF23 ATP6V1D FGF22 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 SRF ATP6V0A1 CDK5R1 MAPK3 PTPN1 INSR PTPN11 FGF16 CDC42 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FAM83B FGF10 HNRNPM HNRNPF SRC NRG1 DOCK3 GRIN2B HNRNPH1 DLG4 CALM1 DOCK1 FLT1 FLT4 KDR VEGFB VEGFC PTK2B VEGFD THBS1 PGF VEGFA ERBB2 ESRP1 MEMO1 CTNND1 CTNNA1 BAX CSK JAK2 SPRED2 RANBP9 SPRED1 CD274 IL2RG NELFB CHEK1 MMP9 BRAF MAP2K5 NCBP1 NRP2 NCBP2 CDH5 FRS3 TNS4 TNS3 LCK FYN HGF FGFRL1 FLRT2 FLRT1 CLTC CLTA AP2A1 NTRK3 AP2A2 NTF3 PDGFB AP2M1 RAP1B RAP1A PRKACG IGF2 PRKACA PRKACB IGF1 AP2S1 CXCL12 PTBP1 AP2B1 PLG STAT5A LAMA5 SH3KBP1 PXN LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 GRAP2 LAMC1 JAK3 HNRNPA1 PDGFRA KIT PTK6 HBEGF HDAC1 FLRT3 SIN3A NAB1 CTNNB1 COL6A2 NAB2 MET COL4A4 LYL1 F3 DNM2 COL6A1 ARC COL4A3 TRIB1 PTPRK TPH1 EPS15L1 ATF2 RRAD EPN1 ASCL1 SPRY1 PTPN3 EGR1 COL6A3 EGR2 EGR3 JUND COL4A5 EGR4 COL6A6 FOSL1 COL6A5 ID2 MLST8 ID1 MYCN MEF2C ID4 FOSB ID3 MYC CDK5R2 SPINT1 TGFBR3 HPN SPINT2 HGFAC MTOR YWHAB HSPB1 LRIG1 SOCS6 SH2B3 AKT1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 NCF2 NCF4 BRK1 MAPKAPK2 UBA52 MATK GIPC1 ANOS1 CYBB CYBA UBB RAPGEF1 UBC RPS27A RNF41 CUL5 MAPK14 MAPK11 PAK1 NCKAP1L WASF1 IRS4 PAK2 IGF1R CILP WASF2 CAV1 ERBIN BAIAP2 ABI2 FURIN PCSK6 ABI1 NGF PCSK5 SPP1 RICTOR ROCK1 ROCK2 ADAM12 STAT1 ELMO1 HSP90AA1 NEDD4 EGF CBL JUP EGFR CDC37 PLCG1 STMN1 RBFOX2 PDGFD SHB FGFBP3 FGFBP1 FGFBP2 ARF6 ALKAL2 ALKAL1 TIA1 TNK2 DOCK7 ADAP1 ESRP2 PTPRZ1 CSN2 TIAL1 SH2D2A PAG1 RANBP10 PTPRO PTN AXL PLAT FAM83D FAM83A MXD4 LTK EP300 THBS4 RASA1 THBS3 PRKCZ PAK3 BCAR1 NRP1 MAP2K1 MAP2K2 NRG3 ITGB3 NRG4 NRG2 ITGAV COL4A2 COL4A1 PTPRS SPARC STAT3 HDAC3 ITGA2 GABRG3 APOE GABRG2 COL9A1 GABRB3 COL9A3 GABRB2 COL9A2 GABRB1 NCOR1 GGA3 HDAC2 STUB1 STAT5B GABRQ GABRA1 GRB2 THBS2 ATF1 GALNT3 DNMT1 MAPKAPK3 MUC20 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 PTPN6 YES1 MEF2D STAT6 NTF4 PDGFRB S100B NTRK2 BDNF TGFA TAB2 FOS ELK1 PTK2 EREG BTC EPGN AKT3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 95%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HPGDS TBXAS1 PTGES PTGES2 PTGR2 CBR1 PTGIS PTGS2 PTGS1 CYP8B1 AKR1C3 PTGES3 PTGDS HPGD PRXL2B ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 95%114294 Activation, translocation and oligomerization of BAX BAX BID CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 95%5690714 CD22 mediated BCR regulation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 CD22 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 LYN IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGHD IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PTPN6 ASPIRIN ADME%REACTOME DATABASE ID RELEASE 95%9749641 Aspirin ADME CYP2E1 UGT2B7 CYP2C9 UGT1A3 CYP2C8 ABCC2 CYP2C19 ACSM2B ABCC3 CYP2D6 SLC16A1 SLC22A7 UGT2B28 ALB CES2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 BCHE UGT3A1 UGT2A1 UGT1A8 GLYATL3 BSG UGT1A7 GLYATL2 UGT1A6 GLYATL1 ACSM2A CYP3A4 UGT2B10 ACSM5 UGT2B11 GLYAT UGT1A1 CES1 ACSM4 UGT2B15 UGT1A9 UGT2B17 UGT2B4 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 95%9723907 Loss of Function of TP53 in Cancer TP53 INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection CLTC KPNA7 KPNA4 KPNA5 CLTA GBP1 KPNA3 CPSF4 TGFB1 EIF2AK2 ISG15 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 KPNA1 PABPN1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A6 NUP37 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 MLKL RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PARP1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 CALR CANX RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 XPO1 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A NUP214 RPL23A RPL3L RPL27A RPL22L1 RPL26L1 POLR2A POLR2B POLR2C POLR2D POLR2E RAN POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L RPLP0 GTF2F1 GTF2F2 RPS27A IPO5 HSPA1A KPNA2 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling GNG13 CLTC CLTB WNT5B FZD7 WNT5A ROR1 GNB2 ROR2 CLTA GNB1 AP2A1 PRICKLE1 WNT1 FZD1 MAP3K7 GNB4 AP2A2 RYK FZD8 GNB3 GNB5 AP2M1 GNGT1 GNGT2 PRKG2 AP2S1 GNG3 SMURF2 ITPR1 ITPR2 GNG2 ITPR3 GNG5 AP2B1 GNG4 GNG7 GNG8 ARRB2 SCRIB VANGL2 DAAM1 PFN1 PARD6A PRKCB RAC1 DVL1 DVL2 DVL3 PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 RAC2 GNAO1 TCF7L2 TCF7L1 LEF1 TCF7 RHOA CTNNB1 TNRC6C MOV10 AGO3 AGO4 SMURF1 AGO1 AGO2 TNRC6A TNRC6B CAMK2A PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 CALM1 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 RAC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 WNT4 PSMC1 PSMC2 PRKCG GNG10 GNG12 GNG11 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 RB1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 ANAPC2 SKP2 ANAPC15 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 95%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.4 Transport to the Golgi and subsequent modification PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 FUCA1 MGAT3 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 B4GALT6 SEC22B B4GALT5 MAN2A2 LHB SERPINA1 SEC23A COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 MANEA TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B B4GALT2 TRAPPC3 B4GALT3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A B4GALT4 TRAPPC6B CGA SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 FUT8 NSF MAN2A1 CTSC MGAT5 CAPZA3 MGAT1 MGAT2 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A MGAT4C TMED2 MGAT4A SPTB DYNC1I1 MGAT4B B4GALT1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 ST6GAL1 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ST3GAL4 ANK1 AREG ST8SIA6 DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 ST8SIA2 TGFA ST8SIA3 YKT6 ARFGAP1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 95%170968 Frs2-mediated activation MAPK1 RAPGEF1 RAP1A FRS2 NGF MAP2K1 MAP2K2 CRKL MAPK3 BRAF YWHAB RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73728 RNA Polymerase I Promoter Opening H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MBD2 MAPK3 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 95%9706377 FLT3 signaling by CBL mutants UBC RPS27A FLT3LG CBL UBA52 FLT3 UBB MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins FURIN CSNK2A1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 95%9734207 Nucleotide salvage defects APRT HPRT1 ADA TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A KIT MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9669921 KIT mutants bind TKIs KIT HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.4 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 RNF8 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 95%4717374 Defective DPM1 causes CDG-1e DPM3 DPM1 DPM2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 95%5619114 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope DSG1 DSG3 FURIN PERP PCSK6 LCE6A IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KLK13 KLK14 LCE3E KLK12 LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A LCE1B KAZN LIPJ LIPN LIPM JUP PRSS8 PI3 LIPK PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 LCE1E LCE1F LCE1C CAPNS1 LCE1D LCE2B PKP4 LELP1 CAPN1 LCE2C LCE2A LORICRIN FLG SPRR2E SPRR2F DSG2 SPRR2G TCHH PKP1 KLK5 KLK8 PPL CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN SPRR1A SPRR1B DSG4 CASP14 LCE5A DSP PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 95%156580 Phase II - Conjugation of compounds UGT2B7 GSTA3 GSTA1 COMT HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM MGST3 MGST1 MGST2 GSTP1 MTRR MAT1A NNMT CYP1A2 MAT2B AHCY SLC35D1 SLC35D2 SULT2A1 TPST2 TPST1 GSTM4 TPMT AS3MT AKR1A1 GSTT2 GSTT1 ESD GSTT2B UGT1A3 GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 MAT2A GSTA5 GSTA4 CHAC1 PODXL2 ABHD14B SULT1A1 SULT1C2 SULT1B1 SULT1E1 ACSM1 BPNT2 ACSM2B BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 MTR HPGDS GSTZ1 GSTO1 NAT1 NAT2 GSTA2 UGT1A10 UXS1 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 UGDH UGT2B4 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME%R-HSA-2129379.3 Molecules associated with elastic fibres FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB5 GDF5 MFAP5 BMP4 MFAP4 MFAP3 MFAP2 TGFB1 VTN ITGB6 ITGA8 BMP7 TGFB2 TGFB3 BMP2 BMP10 LTBP4 ITGB3 FBLN1 ITGB1 LTBP3 FBLN2 LTBP1 ITGAV RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5213460 RIPK1-mediated regulated necrosis XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane CEP41 CEP43 DYNLL1 CKAP5 TUBA1A RPGRIP1L PRKACA MAPRE1 PAFAH1B1 DYNC1I2 MKS1 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 YWHAE CEP97 CC2D2A TUBB4B IQCB1 TUBB4A KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 MARK4 YWHAG SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 RAB3IP CEP290 NINL RAB11A CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 95%9033500 TYSND1 cleaves peroxisomal proteins ACOX1 HSD17B4 AGPS SCP2 ACAA1 PHYH TYSND1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111447 Activation of BAD and translocation to mitochondria YWHAH YWHAZ SFN BCL2 AKT2 YWHAB PPP3CC BID YWHAE AKT1 PPP3R1 BAD YWHAQ YWHAG AKT3 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 95%4793954 Defective MOGS causes CDG-2b MOGS STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants STAT5A STAT5B BCL2L1 CDKN1A GRB2 GAB2 FLT3 NOX4 PIM1 PTPN11 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 95%1855183 Synthesis of IP2, IP, and Ins in the cytosol INPP5B SYNJ1 INPP5A IMPA1 MTMR9 INPP4A IMPA2 MTMR7 INPP4B INPP5J MIOX ISYNA1 OCRL INPP1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 GLYAT VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964046 VLDL clearance APOC4 LSR APOB VLDLR APOBR APOC1 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 95%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%1614635 Sulfur amino acid metabolism MRI1 ENOPH1 BHMT2 FMO1 BHMT ADI1 GOT2 MPST TSTD1 SQOR GADL1 SUOX ADO CSAD TXN2 MAT1A TST ETHE1 SLC25A10 CDO1 AHCY CBS MTAP CTH MTR GOT1 APIP MTRR TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 F9 PROC F10 PROS1 PROZ F2 BGLAP GAS6 INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168249 Innate Immune System RELA ARPC1B ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 RAB9B IRAK1 NCKIPSD MGST1 C4A CAT RETN FUCA2 DNAJC3 RAC1 VAV3 CST3 PRKCQ UBE2N VAV1 VAV2 CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 NFATC2 V1-11 CPB2 CFH V1-16 V1-13 MAPK8 C5AR2 CFI CDK13 CAPZA2 C5AR1 C4B_2 C2 ACTR10 C5 HSPA1B C6 SOCS1 C7 C9 CD19 IKBKB V2-8 V1-20 MYD88 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S UBE2D2 C1R UBE2D3 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC SNAP25 RAB3A POLR2E POLR2F POLR2H POLR2K DNAJC5 POLR2L KRT1 TOLLIP ACTB CSNK2B CNPY3 TLR8 CTSB TP53 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 PYGL MMP25 TIMP2 OLR1 SERPINB3 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 CCT8 GSTP1 AGA AOC1 AGL TUBB4B ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RAB5B NLRC4 RAB5C BRI3 DSC1 HVCN1 GPR84 RAB6A TXNDC5 TRAPPC1 RAB4B PTPRB PTPRC NIT2 ITGAM ITGB2 ACTG1 FCAR ALAD FCGR3B PPP2R1B PGM2 PPP2R1A ACP3 SNAP29 PGM1 RNASET2 TNFRSF1B DYNC1LI1 PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 CPPED1 RAB10 NFASC TSPAN14 FCGR2A DSN1 RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 CHIT1 TXN DIAPH1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PPP2R5D PRG3 DYNLL1 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 RHOA HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 CHUK MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA DNASE1L1 PPP2CB CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 DYNC1H1 LAIR1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CD93 CASP1 CD300A CASP2 IRAG2 ATAD3B OSCAR TYROBP DOK3 CRCP COPB1 ADGRG3 DPP7 MGAM POLR3GL HSPA6 GGH POLR3A POLR3B DNAJC13 ADA2 POLR3C IGF2R POLR3D POLR3E SELL TARM1 POLR3F POLR3G MAN2B1 MS4A3 POLR3H DDX3X TNFAIP6 POLR3K CRISP3 CXCL1 SLC2A5 SIRPB1 HEBP2 NFKB2 ADGRE5 NAPRT ADGRE3 FGB HGSNAT DYNLT1 ATP6AP2 FGA PLAUR LRRFIP1 MMP8 MMP9 FGG CHI3L1 PDXK BIN2 FCN2 CLEC12A MVP FCN3 CAND1 CRP COLEC10 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN SKP1 PROS1 F2 CUL1 AP2A2 SLC15A4 RASGRP2 RASGRP1 RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB NPC2 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 LBP IGKV3-20 IGHV4-34 IGHV1-2 ITK IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 VTN IGLC2 BTRC IGKV3D-20 TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C AMPD3 IGKV5-2 APRT IGLC6 IGKV1-5 PNP IMPDH1 IMPDH2 LIMK1 PPP3CA EEF1A1 MYH9 PPP3CB UBE2L6 HERC5 PPP3R1 NFATC1 HLA-H HLA-B HLA-C HSP90AB1 IGHE HLA-E CDC34 DNM2 ATG7 CAB39 CTSS VAMP8 TLR6 HUWE1 IKBKE LAMTOR2 IRF7 LAMTOR1 TANK LAMTOR3 CYFIP1 NCKAP1 NCF1 NCF2 NCF4 SNAP23 BRK1 STBD1 CEP290 NFATC3 TUBB S100A1 CYBB CYBA RAB7A UBE2V1 UBA7 UBR4 PAK1 MEFV PSTPIP1 NCKAP1L SUGT1 WASF1 PAK2 WASF2 CALM3 CALM2 RASGRP4 BAIAP2 ATP8A1 ABI2 UBA3 ABI1 UBE2K ATP11B UBE2M ATP11A TIRAP CARD11 MALT1 ATP8B4 RELB CLEC10A CLEC7A CARD9 CLEC4A WIPF1 CLEC4E MAP3K14 WIPF2 CLEC6A DHX58 WIPF3 RNF125 TAX1BP1 RNF216 FCGR1A ARHGAP45 IQGAP1 ANO6 PLD1 IQGAP2 JUP ARHGAP9 WASL WAS STOM PAK3 MYO9B MAP2K1 COLEC11 HSP90B1 ITGAV FTH1 MASP1 FTL XRCC6 XRCC5 ITGAX DGAT1 FABP5 SIKE1 GPI CD36 HK3 KLRK1 PGAM1 KIR3DS1 DHX36 PRKDC FCER1A LAT2 NCR2 BCL10 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E NKIRAS2 LPO MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 TLR10 BCL2 TLR5 ALPK1 LRRC14 NLRX1 PELI3 BCL2L1 PELI2 PTPN6 NLRC5 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 STAT6 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB ELK1 POLR1C PTK2 POLR1D IFNA5 IFNA4 IFNA7 IFNA6 JUN IFNA2 IFNA8 AGPAT2 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 CD209 GM2A NOS1 APEH ARSA FGR ASAH1 PECAM1 ITPR1 ITPR2 ITPR3 PSAP TKFC APOB MBL2 NOS2 NOS3 MME GLA P2RX7 CRK P2RX1 FADD IST1 CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 KPNB1 IL1B PELI1 TLR4 GSN TICAM2 TICAM1 PKP1 LY96 SDCBP HMGB1 CASP8 CASP5 CASP4 DSP DUSP4 DSG1 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 PRKCSH MAGT1 LTA4H NCSTN ADAM10 PSEN1 DNM1 GOLGA7 LGMN DDOST LPCAT1 ALOX5 DNM3 MAPK12 MAPK13 TRIM25 HPSE LYN BTK CYLD CNN2 CFL1 IFIH1 TRIM4 IKBKG ANXA2 TOMM70 RIPK2 MIF CAPZA1 AAMP PPIA RNF135 AHCYL1 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 NFKBIA MAVS CYFIP2 TAB1 RIGI TNFAIP3 HMOX2 SLC44A2 GLIPR1 TRAF2 TEC TRAF3 TRAF6 BIRC2 BIRC3 STK10 USP14 NOD1 NOD2 USP18 ORMDL3 PIK3CB TCIRG1 PTGES2 NCK1 TNIP2 ATP6V1E1 CTSD ATP6V1E2 WASF3 HRAS ATP6V1G1 ATP6V0B CD180 ATP6V0E1 LY86 ATP6V1G2 EEA1 PDPK1 TASL RBSN IRF5 GAB2 PIK3CA ATP6V1B2 TLR9 PIK3C3 ATP6V0D1 FAF2 SOS1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS ATP6V0A2 PLD4 ATP6V1H MAPK1 PLD3 ATP6V0A4 PANX1 DHX9 ATP6V0E2 ATP6V1G3 ATP6V1D ALDH3B1 ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PCBP2 PTPN11 PLD2 DEGS1 UNC93B1 TLR3 CKAP4 LRRC7 CALM1 DOCK2 DOCK1 MOSPD2 UBE2D1 MRE11 ARMC8 MYO5A FBXW11 OPTN RAB27A CEACAM1 SEM1 APP LAMP2 PPIE ARG1 SERPING1 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B S100A7A HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 SERPINA3 DEFB117 DEFB116 ORM1 FPR2 SLC11A1 SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 ORM2 DEFB110 TLR1 DEFB130A BPI QSOX1 PRTN3 DEFB130B S100A9 CAP1 DEFB4B S100A8 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PTAFR PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 ACLY ATG5 ATG12 SLC27A2 CTNNB1 ACAA1 ATF2 TREM2 SIGIRR IRAK3 MEF2C B4GALT1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 KCNAB2 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 CASP10 ICAM3 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A CASP9 APAF1 CASP3 CFD C3 GZMM CFB VAPA CCT2 ROCK1 ZBP1 TREX1 DDX41 DTX4 TBK1 B2M IRF3 STING1 AP1M1 NLRP4 TRIM32 TRIM21 TRIM56 ELMO1 HEXB GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 FRK PLCG1 EP300 NDUFC2 NFKB1 PIN1 CHRNB4 ITGAL MUC12 MUC15 PTPN4 MUCL1 MUC3A MUC5AC MUC3B LGALS3 CFP MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 NEU1 MUC5B MUC20 MUC21 CTSA YES1 EEF2 MLEC CTSV CTSL CTSK MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation MAPK1 TYK2 JAK2 JAK1 IL6R MAP2K2 PTPN11 IL6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling SMPD2 NGFR NGF VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability HSP90AA1 JUP CTNND1 THEM4 CTNNA1 RICTOR CTNNB1 CDH5 MLST8 AKT2 PAK1 PAK3 MTOR RAC1 VAV3 NOS3 PRR5 PDPK1 PAK2 AKT1 VAV1 CALM1 CAV1 VAV2 MAPKAP1 AKT3 TRIB3 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB GLYCTK KHK ALDH1A1 TKFC REGULATION OF CDH1 FUNCTION%REACTOME%R-HSA-9764561.1 Regulation of CDH1 Function RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC VCL PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP MYOGENESIS%REACTOME DATABASE ID RELEASE 95%525793 Myogenesis CDON ABL1 CTNNA1 CTNNB1 MAP2K6 CDC42 CDH2 NEO1 NTN3 CDH4 BNIP2 MEF2C CTNNA2 MYOG SPAG9 MEF2B MAPK14 MYOD1 MAPK11 MYF6 TCF4 MEF2D CDH15 MYF5 TCF3 TCF12 MAPK12 MEF2A RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 95%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known SMARCB1 SMARCD1 SMARCD2 SMARCD3 PCGF5 HIPK2 SMARCC1 SMARCC2 RYBP ARID2 YAF2 SMARCE1 ACTL6A BMI1 CBX6 EP300 RING1 AUTS2 CSNK2A1 CSNK2A2 RNF2 SMARCA2 RUNX1 ACTL6B SMARCA4 CSNK2B CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 CBFB ARID1A ARID1B PBRM1 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 95%3371378 Regulation by c-FLIP RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 95%8852276 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA5 PLK1 PSMA6 PSMA3 PSMA4 HSP90AA1 PSMA1 CCNB1 PSMA2 CDKN1A UBA52 PSMD12 HSP90AB1 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 MAPRE1 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A GTSE1 FKBPL ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 CCNB2 PSMD2 TP53 PSMD3 PSMD1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 95%8941284 RUNX2 regulates chondrocyte maturation GLI2 IHH HDAC4 CBFB BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%162588 Budding and maturation of HIV virion NEDD4L CHMP3 CHMP6 CHMP7 UBA52 UBB UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A PPIA VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 PDCD6IP MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MT-ND4L GFM2 MRRF MT-CYB MTRF1 MTRF1L MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 UBA52 IFNA10 IFNA21 IFNB1 EIF2AK2 IFIH1 JAK1 UBB CREBBP UBC TYK2 RPS27A STAT2 EP300 IRF3 CUL5 IFNAR1 MAVS RIGI ELOB ELOC RBX1 TRIM25 IFNA5 IFNA4 IFNA7 IFNA6 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential KCNK17 KCNK18 KCNJ2 KCNJ4 KCNJ14 KCNK5 KCNK2 KCNK3 KCNK12 KCNK4 KCNK15 KCNK9 KCNJ12 KCNK6 KCNK7 KCNK1 KCNK10 KCNK13 KCNK16 SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 PHOSPHO1 LPIN1 LPIN2 LPIN3 CHKB ETNPPL CEPT1 CHKA ETNK2 SELENOI PISD ETNK1 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 95%9793528 Ciprofloxacin ADME SLCO1A2 SLC22A8 ABCG2 ALB SLC22A1 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling NRG1 HBEGF PIK3R1 PIK3CA NRG3 EREG NRG4 BTC NRG2 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 95%164378 PKA activation in glucagon signalling GNAS ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 PRKAR1B ADCY6 PRKAR2B ADCY5 PRKAR1A PRKAR2A PRKACG PRKACA PRKACB DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 95%9734779 Developmental Cell Lineages of the Integumentary System PRL FGF10 TGFA AREG EGF MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 95%5654741 Signaling by FGFR3 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 MAPK3 BRAF UBB GALNT3 PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 FRS3 RPS27A FGF4 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 95%8983432 Interleukin-15 signaling SOS1 IL15RA STAT5A STAT5B IL15 SHC1 STAT3 IL2RB SOS2 GRB2 JAK3 JAK1 GAB2 IL2RG PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.4 Phase 0 - rapid depolarisation CACNG4 FGF14 FGF13 FGF12 FGF11 SCN9A SCN11A CACNG6 CACNG7 SCN10A SCN8A CACNA1C RANGRF SCN5A CACNB1 SCN4A SCN4B SCN7A CAMK2B SCN1B SCN1A CAMK2D CAMK2A CACNA2D2 CACNB2 SCN3B SCN3A CACNG8 CALM1 CAMK2G SCN2A SCN2B SIGNALING BY HEDGEHOG%REACTOME DATABASE ID RELEASE 95%5358351 Signaling by Hedgehog EVC2 IQCE EFCAB7 SEL1L EVC BOC GAS1 ADCY9 DRC4 CDON ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 IFT172 ADCY6 ITCH IFT52 ADCY5 IFT57 DYNC2H1 PRKACG IFT140 RPGRIP1L CUL3 PRKACA KIF7 PRKACB WDR35 IHH IFT88 VCP SMO GPR161 INTU TULP3 KIF3A TTC21B PTCH1 WDR19 IFT122 FUZ ADCY10 MKS1 DERL2 ERLEC1 SMURF2 OS9 ADAM17 P4HB ARRB1 ARRB2 GNAS GLI1 SUFU BTRC NUMB PRKAR1B PRKAR2B PRKAR1A PRKAR2A NOTUM SPOP GLI3 GLI2 SMURF1 GPC5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 OFD1 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 DISP2 PSMC2 ULK3 SCUBE2 GRK2 SKP1 DZIP1 SPOPL SYVN1 CUL1 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839124.4 FGFR1 mutant receptor activation CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 TRIM24 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 ZMYM2 FGFR1OP2 GAB2 PIK3CA MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 95%2565942 Regulation of PLK1 Activity at G2 M Transition CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A AJUBA YWHAG PLK1 HSP90AA1 CCNB1 CEP57 CETN2 CEP164 UBA52 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 BTRC CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 PPP1CB HAUS5 CSNK1E UBB PPP2R1A TUBG1 HAUS2 HAUS1 CPAP UBC AKAP9 RPS27A BORA CEP63 SFI1 FBXW11 SDCCAG8 OPTN DCTN2 SSNA1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 SKP1 CCNB2 ODF2 CEP152 NEDD1 ALMS1 CUL1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167238 Pausing and recovery of Tat-mediated HIV elongation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 95%5633008 TP53 Regulates Transcription of Cell Death Genes ZNF420 TNFRSF10C PRELID3A BNIP3L TNFRSF10B TNFRSF10A PERP PRELID1 TNFRSF10D TMEM219 NLRC4 BAX BID BIRC5 TP63 PPP1R13B FAS CREBBP CHM BBC3 RABGGTB RABGGTA NDRG1 BCL6 CASP10 PMAIP1 STEAP3 AIFM2 TP53AIP1 TP53INP1 CRADD TP53I3 IGFBP3 TP73 TP53 CASP6 ATM CASP1 TRIAP1 CASP2 PIDD1 TP53BP2 APAF1 BCL2L14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 IGLV2-11 IGLV1-40 HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LRP1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 95%5083635 Defective B3GALTL causes PpS ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4C GPCPD1 PLA2G15 PLA2G4F PLBD1 PLA2G4D PLA2G4E PLA2G4A PLA2G4B CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF5 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 EIF5B RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 EIF4EBP1 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 95%5579031 Defective ACTH causes obesity and POMCD MC2R POMC DEPYRIMIDINATION%REACTOME%R-HSA-73928.3 Depyrimidination MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 95%264870 Caspase-mediated cleavage of cytoskeletal proteins GSN SPTAN1 DBNL PLEC CASP8 CASP6 ADD1 GAS2 CASP7 MAPT CASP3 VIM REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 95%3371453 Regulation of HSF1-mediated heat shock response CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSF1 HSPA2 MAPK3 HSPA1B HSPH1 YWHAE NUP205 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA9 HSPA8 RPA1 RPA2 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 95%983168 Antigen processing: Ubiquitination & Proteasome degradation MIB2 ITCH UBE2L3 BTRC RNF111 UBE2V2 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 UBE2N HERC3 RNF115 HERC2 NEDD4L RNF114 HERC1 FBXO7 HERC6 FBXO9 WSB1 FBXO2 RNF126 CDC34 HECW2 RBCK1 CBLL2 TRIM11 ANAPC13 FBXL18 UBE2J2 FBXL7 UBE2J1 RNF213 RNF217 ATG7 SOCS1 HACE1 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 LRRC41 RNF144B UBE2D2 PSMD8 GAN UBE2D3 KEAP1 PSMD6 RNF138 PSMD7 ELOB RNF130 ELOC HUWE1 PSMD2 KLHL2 RBX1 KLHL3 PSMD3 UBE2G1 UBE2G2 CUL2 PSMD1 VHL KLHL9 RNF123 SPSB2 SPSB1 KBTBD6 KLHL5 PSMA5 RLIM PSMA6 TRIP12 PSMA3 KBTBD7 PSMA4 KBTBD8 PSMA1 SPSB4 UBE3C PSMA2 UBE2D4 UBE3D FBXO27 UBA52 SIAH2 LTN1 RNF19B UBE3A PSMD12 UBE3B PSMD11 FBXO21 WWP1 UBE2Z PSMD14 FBXO22 NPEPPS PSMD13 RNF19A PSMA7 FBXW12 PSMB6 AREL1 FBXW8 PSMB7 UBE2E3 TRIM4 PSMB4 FBXO17 PSMB5 FBXO15 UBE2E2 UBB PSMB2 UBE4A PSMB3 LMO7 FBXO10 FBXO11 UBC FBXO4 PSMB1 KLHL41 KCTD7 FBXO6 RPS27A TRAIP RNF41 KLHL42 UBE2V1 PRKN FBXW4 CUL7 FBXW5 CUL5 FBXW10 UBA7 ADRM1 UBA6 FBXW7 UBA5 PSMC5 FBXW9 UBR4 PSMC6 KLHL11 PSMC3 UBR2 PSMC4 FBXW2 UBR1 PSMC1 KLHL13 PSMC2 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 FBXL3 UBA3 UBE2O FBXL5 TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 RNF14 KBTBD13 CUL3 UFL1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 PJA1 RBBP6 TRAF7 UBE2R2 THOP1 TRIM50 MGRN1 SMURF2 ASB13 ASB14 ASB11 RNF6 ASB12 RNF7 TRIM32 TRIM21 ASB17 RNF4 ASB18 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 TRIM41 RNF25 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 NEDD4 FBXL12 MKRN1 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 RNF34 TRIM36 TRIM37 ASB4 FZR1 ASB5 ASB2 ASB3 SKP2 ASB1 CDC20 SOCS3 SH3RF1 FBXO32 MYLIP TRIM63 KCTD6 SMURF1 ANAPC7 UBE2C STUB1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 FBXL21P SEM1 SKP1 CUL1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RRAS RAC1 PLXNB1 MET RND1 ARHGAP35 SEMA4D RHOA PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%1989781 PPARA activates gene expression MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA TNF SIGNALING%REACTOME DATABASE ID RELEASE 95%75893 TNF signaling XIAP RACK1 TRAF1 ULK1 MAP3K7 USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 RBCK1 NSMAF SMPD3 SMPD2 CHUK IKBKB RIPK1 SHARPIN TBK1 ADAM17 TAX1BP1 TAB1 UBE2D2 UBE2D3 TNFAIP3 RNF31 IKBKE SPATA2 TNFRSF1A OTUD1 STUB1 UBE2L3 TRAF2 BAG4 UBE2D1 MAPKAPK2 UBA52 BIRC2 FADD BIRC3 CYLD OTUD7B IKBKG UBB UBC RPS27A USP21 TNF OPTN OTULIN TRADD TAB3 TAB2 CASP8 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels KCNK17 KCNK18 KCNK6 KCNK7 KCNK1 KCNK2 KCNK3 KCNK10 KCNK4 KCNK9 KCNK13 KCNK16 TCR SIGNALING%REACTOME DATABASE ID RELEASE 95%202403 TCR signaling RELA MAP3K7 PTPN22 CARD11 MALT1 NFKBIA PTEN PLCG2 VASP ITK TRAC CD3G CD3E TRAF6 PLCG1 CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 PTPRC ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 CD4 HLA-DRB1 PAG1 HLA-DQB2 LAT PIK3CB CD101 HLA-DQB1 NCK1 WAS PAK3 PDPK1 PRKCQ PIK3CA UBE2N PIK3R2 PIK3R1 NFKB1 CDC34 PTPRJ EVL CHUK IKBKB UBE2D2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 ZAP70 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 INPP5D PSMA2 TRAT1 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 CSK PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB RIPK2 PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 SEM1 LCK PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TAB2 PAK2 CUL1 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism MCEE MMAA PCCA MMUT PCCB AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME DATABASE ID RELEASE 95%174084 Autodegradation of Cdh1 by Cdh1:APC C PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production RACK1 NSMAF SMPD3 SMPD2 TNF TNFRSF1A DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 95%9675132 Diseases of cellular response to stress CDK6 CDK4 CDKN2A GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade RAC2 LYN RHOG PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 RHOA RHOB GP6 FCER1G LCP2 PTPN11 PIK3CB CDC42 LAT PDPN MPIG6B CLEC1B PTPN6 PRKCZ SYK RAC1 LCK FYN VAV3 PDPK1 PLCG2 PIK3R3 PIK3CA VAV1 VAV2 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 95%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template PCNA UBA52 NPLOC4 POLH USP10 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.6 Defective EXT1 causes exostoses 1, TRPS2 and CHDS AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1 TGIF2 CCNK SERPINE1 FURIN CCNC HDAC1 CDKN2B UBA52 MAPK1 COL1A2 CCNT1 TFDP1 MAPK3 TFDP2 UBB UBC CDK8 SP1 SMAD2 RPS27A SMAD4 CDK9 YBX1 SMAD3 EP300 SMAD7 MYC JUNB RNF111 MEN1 WWTR1 E2F4 CCNT2 E2F5 RBL1 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 95%5579024 Defective MAT1A causes MATD MAT1A MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation TYK2 JAK2 JAK1 MAP2K1 IL6R MAPK3 CDK1 PTPN11 IL6 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 95%4341670 Defective NEU1 causes sialidosis NEU1 GLB1 CTSA FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190371 FGFR3b ligand binding and activation FGF18 FGF1 FGF9 FGF20 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%5660489 MTF1 activates gene expression MTF1 CSRP1 SNCB BILE ACID AND BILE SALT METABOLISM%REACTOME%R-HSA-194068.3 Bile acid and bile salt metabolism RXRA OSBP NCOA2 AMACR SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 SLC51A NCOA1 SLC51B CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 SLCO1A2 OSBPL1A ABCB11 AKR1C1 FABP6 ABCC3 AKR1C2 ALB AKR1C4 SLC10A1 SLC10A2 CYP8B1 STARD5 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs CYP2E1 CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles BANF1 PSIP1 HMGA1 OPSINS%REACTOME%R-HSA-419771.3 Opsins OPN1MW OPN1LW RHO OPN1SW OPN4 OPN3 RRH RGR OPN5 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 95%3560783 Defective B4GALT7 causes EDS, progeroid type CSPG4 AGRN B4GALT7 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 95%430039 mRNA decay by 5' to 3' exoribonuclease LSM1 PATL1 EDC3 EDC4 DCP1B XRN1 DCP2 DCP1A LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 DDX6 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 95%210745 Regulation of gene expression in beta cells HNF1A MAFA RFX6 IAPP FOXA3 GCK FOXO1 PDX1 INS NKX6-1 AKT2 PAX6 SLC2A2 HNF4G AKT1 FOXA2 NEUROD1 NKX2-2 AKT3 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.3 U12 Dependent Splicing SNRNP200 SNRPD2 SRSF6 SNRPD1 SRSF7 SNRPD3 SNRPB PRPF8 ZMAT5 RNPC3 ZRSR2 DDX42 YBX1 SRSF1 DDX23 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E POLR2F POLR2G POLR2H SF3B1 POLR2I POLR2J POLR2K POLR2L GTF2F1 SNRNP40 GTF2F2 PDCD7 SNRNP48 EFTUD2 NCBP1 NCBP2 TXNL4A SNRNP35 ZCRB1 PRPF6 SNRPG SRSF2 SNRPE SNRNP25 SNRPF CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 95%111957 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 95%5545619 XAV939 stabilizes AXIN TNKS2 TNKS FORMATION OF DEFINITIVE ENDODERM%REACTOME DATABASE ID RELEASE 95%9823730 Formation of definitive endoderm SOX17 SMAD2 SMAD4 GSC SMAD3 MIXL1 TCF7L2 CDH1 GATA6 TBXT EOMES CXCR4 CTNNB1 GATA4 FOXA2 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway MAP3K7 TRAF6 BIRC2 BIRC3 CYLD ITCH CHUK NOD1 MAP2K6 NOD2 IKBKG RIPK2 IKBKB IRAK1 UBE2V1 CARD9 AAMP MAPK14 IRAK2 MAPK11 TAB1 TAB3 TNFAIP3 TAB2 MAPK12 CASP8 MAPK13 CASP1 CASP4 CASP2 CASP9 UBE2N GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 95%500792 GPCR ligand binding FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 TAS2R16 FZD8 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 TAS2R46 RXFP4 MRGPRD FZD10 RXFP1 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R SSTR1 CGA SSTR2 WNT16 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 PTHLH CNR2 CNR1 TSHR ACKR1 C5AR2 C5AR1 C5 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 TAS2R3 TAS2R5 TAS2R4 TSHB PF4 TAS1R2 TAS1R1 TAS1R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 LHB ADORA2B GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CRH WNT3 WNT8A WNT8B NPY CXCR1 CXCR2 OPRM1 OPRK1 POMC CXCL1 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CCR5 CXCR6 CCL7 CXCR4 CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GPR39 EDN1 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH CYSLTR2 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 XCL2 XCL1 HTR2B HTR2C ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 WNT3A WNT9A C3 SMO PTCH1 OPN1LW OXER1 OPN1MW RHO RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 SAA1 MC2R DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.4 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 95%375165 NCAM signaling for neurite out-growth COL4A2 CACNA1D NCAM1 COL4A1 SOS1 NRAS MAPK1 COL6A2 COL4A4 COL6A1 COL4A3 MAPK3 PTPRA CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 SPTB COL6A5 AGRN NCAN SPTBN4 SPTBN5 SPTBN2 PRNP ARTN GFRA1 GFRA2 GFRA4 NRTN CACNA1C SPTAN1 SPTA1 CACNA1S PSPN GDNF CNTN2 ST8SIA4 HRAS FYN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PTK2 SPTBN1 RPS6KA5 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses IFNA2 IFNA8 IFNA13 MAP3K7 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 STAT1 SAR1B NLRP3 SEC23A TBK1 B2M LARP1 IRAK1 IRF3 IFNAR1 STING1 MAVS HLA-A TLR1 TKFC G3BP1 TAB1 G3BP2 RIGI MBL2 CNBP TLR2 NUP205 POM121 NUP107 SFTPD NUP188 IL17RC IL17RA SEC24B AAAS NLRP12 NUP160 SEC24A IL17F POM121C IL17A NUP42 NUP85 TPR NUP62 NUP88 NUP43 HSP90AA1 RAE1 NDC1 TRAF3 RANBP2 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C TLR7 NUP37 NOD1 NOD2 STAT2 UBE2N PIK3C3 MASP1 HLA-H PIK3R4 HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E CHUK PTPN11 IKBKB TRIM25 IKBKE IRF7 SIKE1 NUP214 IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 CREBBP TYK2 UBE2V1 PTPN6 IRAK2 RNF135 TAB3 TLR8 KPNA2 TAB2 IFNA5 IFNA4 IFNA7 IFNA6 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 95%2995383 Initiation of Nuclear Envelope (NE) Reformation PPP2CA PPP2R2A BANF1 SIRT2 CCNB1 VRK1 CDK1 ANKLE2 LEMD2 EMD LBR LMNB1 CCNB2 KPNB1 LEMD3 PPP2R1A SARS-COV-2 MODULATES AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9754560 SARS-CoV-2 modulates autophagy TUFM UVRAG MAP1LC3B VPS41 VPS33B VPS39 VPS18 VPS45 VPS11 VPS16 VPS33A ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity RPS6KA1 HDAC1 LEF1 ZIC1 FOXD3 MAPK1 HINT1 TFE3 MITF TFEC ALX3 TBX3 CTNNB1 MAPK3 EDNRB EPRS1 ID1 CDH1 UBE2I SUMO1 PAX3 YWHAB YWHAE XPO1 SNAI2 GSK3B TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 YWHAZ POMC RARS1 WNT3A SOX10 LARS1 MARK3 AIMP1 AIMP2 QARS1 MARS1 MC1R MC4R DARS1 EEF1E1 MC3R CREBBP KARS1 POU3F2 IARS1 TFEB EP300 MC5R SOX2 SOX9 SIRT1 KIT AKT3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes NFE2L2 IDH1 ME1 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL2 DVL3 CCDC88C CXXC4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9656256 Defective OGG1 Substrate Processing OGG1 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli YAP1 COX5B COX5A RELA COX6C COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C IL6 YWHAE PRR5 EED CAT PDIA6 IGFBP7 SOD2 WFS1 CARM1 PRKCI DNAJC3 MED1 MAPKAP1 PRDX2 PRDX1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 DNAJA4 DNAJA2 CAPZA2 FKBP4 ACTR10 HSPA1B IKBKB SQSTM1 UBE2D2 UBE2D3 HIF3A LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP CDKN2B CSNK2A1 IGFBP1 CSNK2A2 CSNK2B TP53 GNG10 PGR GNG12 GNG11 GNG13 FKBP5 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 MAP2K6 PRDX6 MT2A MT1A MT1M MT1F MT1G MT1H MT1X MT4 MT1B MT3 MT1E GNG3 GNG2 GNG5 CLEC1B GNG4 GNG7 GNA11 GNG8 GSTP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 SMARCD3 NUP210 HMGA1 CACNG7 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 RBBP4 NUP37 RBBP7 TXNRD1 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 COX7A2L TXN RPS27 ITGB1 CITED2 VENTX PPP2R5B DYNLL1 DYNLL2 HBB NFYA NFYB NFYC CHUK DYNC1I2 BMAL1 PPP2CA COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 HM13 EIF2AK3 NOX4 FLT4 KDR HSPA6 HSPD1 VEGFA TLN1 VCL CDH5 PIEZO1 FYN SKP1 CCNA2 CCNA1 CUL1 CXCL8 MTF1 NUDT2 CREB3L3 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 CHD6 PRKACG GPX3 GPX6 PRKACA GPX5 PRKACB GPX8 GPX7 BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 TRPV4 BTRC RPS4Y2 RPS27L RPS4Y1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A GCN1 RPS16 WDR59 RPS19 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT DEPDC5 RPS10 RPS13 KPTN WDR24 RPS12 SH3BP4 RPS9 RPS7 FNIP1 RPS8 FNIP2 PRKAR1B KICS2 RPS5 PRKAR2B CASTOR1 RPS6 PRKAR1A CASTOR2 RPSA PRKAR2A RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 CACNB2 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 HSP90AB1 PRKAA2 SEC31A RPTOR CALR MLST8 SLC38A9 ID1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD AKT1S1 IKBKE LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 NCF1 NCF2 NCF4 BAG4 ACTR1A CYBB CYBA DCTN2 CUL7 DCTN3 PGRMC2 HMGA2 H1-1 H1-0 H1-3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A HSPH1 HYOU1 HBA2 RAMP2 CALCRL ADM ITGB3 HSP90B1 ITGAV ITGA5 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 BMI1 RPL22 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RNF2 RPL12 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 MAP2K3 MAP2K4 CREBBP MAPKAPK3 SP1 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 MAP2K7 MAPK10 FOS FOXO3 PTK2 AKT3 HIKESHI JUN CCAR2 DNAJC2 CXXC1 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 ADCY9 BAG5 DNAJB6 ADCY4 BAG2 ADCY3 BAG3 ADCY2 BAG1 ADCY1 HSPA4 ST13 ADCY8 ADCY7 HSPA7 HSPA12A ADCY6 HSPA12B ADCY5 IFNB1 CSRP1 SNCB PECAM1 GCLC GCLM APOB NOS3 GSK3A P2RX7 GNAS CDKN2D CDKN2C DNAJB11 IL1A FBXL17 BACH1 TLR4 SLC7A11 LY96 OMA1 MAPK7 ADD1 ATF6 CRYAB MAP3K5 DELE1 HERPUD1 MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 KEAP1 AR NRF1 NPLOC4 RPLP0 UBXN7 DPP3 HSPA9 UFD1 IKBKG ANXA2 TALDO1 SOD1 PIK3CD CAPZA1 FKBP14 GOSR2 GPX1 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 KLHDC3 DDX11 WIPI1 YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP NLRP3 ESR1 NFKBIA MDM2 MDM4 GJA1 HMOX2 PKN2 STIP1 PIK3CB TCIRG1 CAPZB AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 PDPK1 PIK3CA ATP6V1B2 EPO TRIB3 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A SHC1 CACNA2D1 PIK3R2 ABCG2 ATP6V1H MAPK1 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 MAPK3 PTPN1 CACNB1 CACNB3 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 HSPE1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN PPP2R2A RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 ATM ATR HSPA5 HSBP1 HSF1 ATP7A DEFA5 CAPNS1 CAPNS2 CAPN2 ATOX1 STOML2 PHB2 YME1L1 P2RY2 CDKN1A CDKN2A SIN3A CDK2 CTNNB1 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 ATF3 ATF4 TNRC6C MOV10 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B PSMD8 PSMD6 TXNIP HMOX1 MT-CO2 PSMD7 MT-CO3 XPO1 PSMD2 KHSRP PSMD3 AKT1 PSMD1 NUP214 DIS3 IDH1 PRKCD PSMA5 PPARGC1A PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 DCP2 PSMD12 SERP1 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 EXOSC5 PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 SIRT1 HSPA1A SIRT3 MMP14 PPARA CYCS SPP1 RICTOR CUL3 STAT1 TRIM21 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 HIGD1A H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KDM6B H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 NFKB1 H2AC20 HDAC3 NRIP1 COX4I1 COX4I2 TBL1X NCOA1 ARNT NCOR2 NCOR1 TBL1XR1 CRTC2 CRTC3 CRTC1 CLOCK NPAS2 HELZ2 RAI1 CHD9 TGS1 MEF2D COX7B GFPT1 COX7C EDEM1 COX8A SYVN1 COX8C INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 95%912526 Interleukin receptor SHC signaling SOS1 SHC1 IL5 IL3RA PIK3R2 INPP5D IL2RB PIK3R1 JAK3 JAK2 JAK1 IL2RG CSF2 PIK3CB PIK3CD PTPN6 IL2 IL3 INPPL1 GAB2 PIK3R3 PIK3CA IL2RA IL5RA CSF2RB CSF2RA IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 95%937042 IRAK2 mediated activation of TAK1 complex UBC TAB3 RPS27A TAB2 MAP3K7 TRAF6 UBA52 IRAK2 UBB TAB1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 95%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.3 Hydroxycarboxylic acid-binding receptors HCAR3 HCAR1 HCAR2 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665230 Drug resistance in ERBB2 KD mutants ERBIN HSP90AA1 ERBB2 CDC37 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 95%392851 Prostacyclin signalling through prostacyclin receptor GNG13 GNB2 GNB1 GNAS GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNG10 PTGIR GNG12 GNG11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME%R-HSA-3359473.4 Defective MMADHC causes MMAHCD MMACHC MMADHC DENGUE VIRUS MODULATES APOPTOSIS%REACTOME%R-HSA-9920951.1 Dengue virus modulates apoptosis RIPK1 RPTOR MLST8 PIK3R4 NFKBIA ATG14 RETREG1 MTOR RICTOR BECN1 TAOK1 PRR5 DAXX NFKBIB PIK3C3 MAPKAP1 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK H2AC20 ERCC6 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MYBBP1A ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 95%9022538 Loss of MECP2 binding ability to 5mC-DNA SIN3A HDAC1 METALLOPROTEASE DUBS%REACTOME DATABASE ID RELEASE 95%5689901 Metalloprotease DUBs BRCC3 UBA52 H2AC20 STAM H2AC1 PSMD14 H2AC25 H2AC21 STAMBP ABRAXAS1 BRCA1 BABAM1 BABAM2 ABRAXAS2 UIMC1 UBB NLRP3 BARD1 UBC H2AC19 H2AC14 RPS27A KAT2B EP300 H2AC8 H2AC6 H2AC7 STAMBPL1 H2AC17 H2AC12 MYSM1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells KLF4 NR5A1 DPPA4 SMAD2 FGF2 SMAD4 STAT3 SALL4 POU5F1 SOX2 NANOG PRDM14 FOXD3 CRIPTO PBX1 LIN28A ZIC3 HIF3A ZSCAN10 EPHA1 EPAS1 SALL1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8931987 RUNX1 regulates estrogen receptor mediated transcription GPAM KCTD6 RUNX1 ESR1 CBFB AXIN1 HORMONE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375281.4 Hormone ligand-binding receptors FSHR CGA GPHA2 LHB TSHB GPHB5 LHCGR TSHR GNRH2 GNRHR2 GNRH1 FSHB GNRHR DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9697154 Disorders of Nervous System Development CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 95%9022702 MECP2 regulates transcription of neuronal ligands DLL1 SIN3A BDNF CRH HDAC1 SST SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 95%198745 Signalling to STAT3 NTRK1 STAT3 NGF NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 95%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 95%202040 G-protein activation GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNA11 GNGT1 GNG8 PDYN POMC GNGT2 GNG10 OPRM1 GNG12 GNG11 FERTILIZATION%REACTOME DATABASE ID RELEASE 95%1187000 Fertilization ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 CD9 ZP3 ZP2 ZP4 HVCN1 SPAM1 B4GALT1 CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 P2Y RECEPTORS%REACTOME%R-HSA-417957.5 P2Y receptors LPAR4 GPR17 P2RY12 P2RY6 P2RY13 P2RY10 P2RY2 P2RY11 P2RY14 P2RY1 P2RY4 LPAR6 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C CTNNB1 AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.5 FRS-mediated FGFR3 signaling FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 FGF9 NRAS FGF20 HRAS FGF23 FRS2 PTPN11 FGF16 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 95%165158 Activation of PKB PDPK1 AKT2 THEM4 TRIB3 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 95%9913351 Formation of the dystrophin-glycoprotein complex (DGC) LAMA5 LAMA2 DRP2 DMD LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 HSPG2 UTRN SNTG2 DAG1 SGCE SGCD AGRN SGCA SGCB SGCG SNTA1 SGCZ DTNA DTNB SSPN SNTB1 SNTB2 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria UBC GBP1 RPS27A UPK1A EPCAM UBA52 HBB GBP2 GBP6 UBE2D2 GBP4 HBA2 CASP4 CALM3 CALM2 CALM1 UBB TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.3 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFSF14 TRAF2 LTA TRAF3 TNFRSF12A TNFSF12 MAP3K14 BIRC2 TNFRSF13C TNFRSF11A BIRC3 CD40LG LTBR LTB TNFSF13B TNFSF11 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.4 O2 CO2 exchange in erythrocytes CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression RXRA NCOA2 SERPINE1 NCOA6 SMARCD3 TBL1X CARM1 BMAL1 NCOA1 CLOCK NPAS2 HELZ2 CREBBP BHLHE40 CHD9 BHLHE41 NAMPT KLF15 TBL1XR1 AVP NOCT MED1 TGS1 F7 BMAL2 PPARA REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors SFN YWHAZ FOXO6 FOXO3 FOXO1 AKT1 AKT2 FOXO4 YWHAQ YWHAG YWHAB AKT3 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 95%9734091 Drug-mediated inhibition of MET activation MET HGF BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9915355 Beta-ketothiolase deficiency ACAT1 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.4 Keratan sulfate biosynthesis CHST2 B4GALT4 CHST3 B3GNT3 ACAN LUM B4GAT1 B4GALT6 B4GALT5 ST3GAL4 SLC35D2 FMOD B4GALT1 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 B4GALT2 B4GALT3 PRELP CHST6 OMD KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 95%192823 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 GRSF1 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 DNAJC3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164525 Plus-strand DNA synthesis PPIA BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol DDX21 NOP56 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 PELP1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 DDX49 RPS28 DDX47 RPS29 WDR3 FCF1 RPS20 FAU RPS21 PWP2 RPS24 RPS27 RPS23 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 RPP30 UTP25 HEATR1 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 RPP38 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 RPP21 UTP4 RPP25 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 RPP40 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPP14 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L DIS3 RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EBNA1BP2 EXOSC7 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E NOB1 EXOSC4 RIOK2 RIOK1 TEX10 SENP3 EXOSC9 MTREX GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 NCL PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 METABOLISM OF FOLATE AND PTERINES%REACTOME%R-HSA-196757.8 Metabolism of folate and pterines DHFR SLC46A1 SHMT1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 MTHFD1L MTHFD2 SHMT2 MTHFD2L SLC25A32 FOLR2 SLC19A1 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 95%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins APBB1IP SOS1 TLN1 FN1 SRC RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME DATABASE ID RELEASE 95%5688354 Defective pro-SFTPC causes SMDP2 and RDS SFTPC FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate TBX6 POU3F1 WNT3A ZEB2 SOX2 FGF8 ZNF521 SOX1 GBX2 OTX2 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 95%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 FMOD PRELP OMD KERA ACAN OGN ST3GAL3 LUM GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XRCC1 POLE4 CUL4A RPA3 PPIE POLE2 POLE3 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 95%201722 Formation of the beta-catenin:TCF transactivating complex H2BC9 H2AZ2 H4C9 H2BC8 BCL9L H2BC5 RUVBL1 H2BC3 H3-4 PYGO1 TCF7L2 H2BC1 BCL9 PYGO2 TCF7L1 HDAC1 H2AC20 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 ASH2L MYC TRRAP DPY30 WDR5 CDC73 AXIN2 LEO1 RBBP5 KAT5 H2AX CREBBP H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B H2BC21 TERT EP300 H3-3B MEN1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 SMARCA4 RUNX3 H2BC13 H2BC14 TLE3 H2AJ H2BC15 H2BC11 H3C15 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF NTRK3 LRRC4B IL1RAPL2 PPFIBP1 PPFIBP2 PPFIA1 PPFIA4 SLITRK3 PPFIA3 PPFIA2 SLITRK5 SLITRK2 SLITRK1 IL1RAPL1 SLITRK4 SLITRK6 PTPRD DEGRADATION OF GABA%REACTOME%R-HSA-916853.4 Degradation of GABA ABAT ALDH5A1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9630794.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 95%418592 ADP signalling through P2Y purinoceptor 1 GNG13 GNB2 GNA14 GNAQ GNB1 GNG3 GNA15 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 MAPK14 GNG7 GNA11 GNGT1 GNG8 GNGT2 GNG10 P2RY1 PLA2G4A GNG12 GNG11 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 95%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones DUOX1 TPO TPH2 IYD ASMT DUOXA1 CGA AANAT DUOXA2 DUOX2 TSHB PNMT DDC TH DBH DIO1 TPH1 DIO2 TXNDC11 CAV1 DIO3 SLC5A5 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 95%5579007 Defective ACY1 causes encephalopathy ACY1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953080.1 MPS VII - Sly syndrome (CS DS degradation) GUSB CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) GRM8 TAS2R4 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GABBR2 TAS2R50 GABBR1 TAS2R19 TAS2R42 TAS2R45 TAS2R40 TAS2R60 TAS2R41 TAS2R43 CASR TAS2R46 TAS1R2 TAS1R1 TAS1R3 TAS2R30 TAS2R7 TAS2R31 GRM1 GRM5 TAS2R38 TAS2R8 TAS2R39 TAS2R20 GPRC6A TAS2R9 GRM3 GRM2 GRM4 GRM7 TAS2R1 GRM6 TAS2R3 TAS2R5 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 95%4839735 Signaling by AXIN mutants APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DNA DAMAGE RECOGNITION IN GG-NER%REACTOME%R-HSA-5696394.2 DNA Damage Recognition in GG-NER ACTR5 RAD23A YY1 ACTR8 RUVBL1 RAD23B PARP1 CETN2 UBA52 INO80 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ACTB UBB TFPT ACTL6A UBC RPS27A DDB2 PARP2 DDB1 COPS7B XPC COPS7A CUL4A COPS3 RBX1 COPS6 COPS5 MCRS1 NFRKB COPS8 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 95%8932506 DAG1 core M1 glycosylations DAG1 POMT2 POMT1 POMGNT1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9652282 Drug-mediated inhibition of ERBB2 signaling ERBIN HSP90AA1 ERBB2 CDC37 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling YWHAZ SOS1 CRK STAT5A STAT5B SHC1 IL5 LYN IL3RA PIK3R2 CBL INPP5D IL2RB PIK3R1 TEC BLNK JAK3 JAK2 PRKACA JAK1 IL2RG PTPN11 CSF2 PIK3CB RAPGEF1 PIK3CD PTPN6 IL2 YES1 HCK IL3 SYK FYN INPPL1 GAB2 PIK3R3 CRKL PIK3CA IL2RA IL5RA VAV1 CSF2RB CSF2RA EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%156842 Eukaryotic Translation Elongation EEF1B2 EEF1A2 RPL4 RPL5 RPL30 RPL3 EEF1G RPL32 RPL31 RPLP1 EEF1D RPL34 RPL10L EEF1A1P5 RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EEF2 RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 95%9865113 Loss-of-function mutations in DBT cause MSUD2 BCKDHA BCKDHB DBT DLD REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.3 Regulation of signaling by NODAL CRIPTO ACVR1B LEFTY2 ACVR2B LEFTY1 ACVR2A CRIPTO3 ACVR1C DAND5 CFC1 CER1 NODAL SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 95%169131 Inhibition of PKR EIF2AK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 95%9734767 Developmental Cell Lineages PRL FGF10 LAMA5 FGF2 LAMA2 LAMB3 AREG LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN TGFA REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation L3MBTL1 EHMT1 SETD9 UBC RPS27A PRMT5 EP300 UBA52 MDM2 MDM4 CHEK2 TTC5 JMY SMYD2 TP53 ATM KMT5A UBB EHMT2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 95%174113 SCF-beta-TrCP mediated degradation of Emi1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 FZR1 BTRC PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 SPOP PSMD12 PSMD11 PSMD14 PSMD13 CCND1 CUL3 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 CDK4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 CSNK2B PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 YWHAG MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis RIPK1 RIPK3 CASP8 MLKL WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL DVL1 DVL2 CSNK2B DVL3 CSNK2A1 CSNK1E PIP5K1B CSNK2A2 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.3 Anti-inflammatory response favouring Leishmania parasite infection GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 95%1253288 Downregulation of ERBB4 signaling WWP1 UBC RPS27A NEDD4 UBA52 SRC UBB ITCH SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R4 GNG13 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B GLYCOGEN METABOLISM%REACTOME%R-HSA-8982491.3 Glycogen metabolism GYG1 GBE1 UBA52 PYGM GYS1 GYS2 PHKG1 PHKG2 GYG2 EPM2A AKR1E2 PHKA1 PHKB PHKA2 PPP1R3C NHLRC1 GAA UBB PYGB PYGL UBC PGM1 RPS27A UGP2 AGL CALM1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) SLC40A1 CP EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 95%9009391 Extra-nuclear estrogen signaling GNG13 GNB2 HBEGF GNB1 GNB4 PIK3R2 GNB3 PIK3R1 PRMT1 GNB5 NRAS GNGT1 MAPK1 GNGT2 GNAT3 CCND1 SPHK1 SRF MAPK3 GNG3 ESR1 GNG2 GNG5 GNG4 GNG7 ESR2 SRC GNG8 GNAI3 NOS3 XPO1 GNAI1 GNAI2 AKT1 CALM1 HSP90AA1 EGF EGFR CDKN1B S1PR3 MMP9 STRN MMP2 BCL2 AREG AKT2 PRKCZ HRAS MMP3 ZDHHC7 PDPK1 TGFA FOS CAV2 FOXO3 ELK1 IGF1R GNG10 MMP7 PTK2 EREG PIK3CA PIK3R3 UHMK1 BTC ZDHHC21 CAV1 GNG12 EPGN AKT3 GNG11 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%418890 Role of second messengers in netrin-1 signaling PITPNA TRPC7 TRPC5 DCC TRPC6 NTN1 TRPC3 TRPC4 TRPC1 PLCG1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 95%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction NEB DMD MYH3 MYH8 MYH6 TNNI1 TNNI2 TNNI3 TMOD3 TPM4 TPM3 DES VIM ACTN3 ACTN2 MYL4 MYL1 MYL2 MYL3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TPM2 TMOD4 TTN TPM1 TMOD2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME%R-HSA-8866910.5 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors CGA YY1 TFAP2A VEGFA ERBB2 TFAP2B ESR1 EGFR TFAP2C CGB8 TGFA KIT ATAD2 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RBM8A PRKACG PRKACA CXCR4 PRKACB ETF1 GSPT2 GSPT1 CXCL12 UPF3A CAP1 UPF2 LDB1 VASP CAP2 ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RAC1 RPSA PRKAR2A RPS3A RPS26 RPS25 PPP3CB RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 SOS2 HOXA2 FLRT3 ZSWIM8 MSI1 LHX3 LHX2 LHX4 LHX9 COL4A5 NELL2 GPC1 PSMD8 PSMD6 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 CUL2 PSMD1 PRKCA ROBO2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 ARHGAP39 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 SLIT1 UBC PSMB1 SLIT3 RPS27A ADRM1 PSMC5 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABL2 EIF4G1 PAK2 PAK4 ABL1 ISL1 DCC NTN1 USP33 SRGAP3 SRGAP1 NCK2 NCK1 PFN1 PFN2 PAK6 PAK3 PAK5 MYO9B SRGAP2 NRP1 EIF4A3 RPS27 SOS1 MAGOH RPL4 RHOA RPL5 RPL30 RPL3 RPL32 RPL31 EVL RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 CDC42 RPL38 RPL37 RPL39 UPF3B RPL21 MAGOHB RPL23 CLASP1 RPL22 CLASP2 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 SRC RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 AKAP5 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 CASC3 NCBP1 NCBP2 SEM1 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 95%4720489 Defective ALG12 causes CDG-1g ALG12 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-177243.4 Interactions of Rev with host cellular proteins NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 RANGAP1 NPM1 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 KPNB1 RCC1 RANBP1 XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 95%180585 Vif-mediated degradation of APOBEC3G PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 ELOB ELOC PSMD2 RBX1 PSMD3 PSMD1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 95%9918476 Assembly and Release of Dengue Virus Virions KDELR1 YBX1 LYN NCL FURIN CLINT1 TSG101 GBF1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events TAF7L CCNT2 TAF4B ELOB ELOC CCNH POLR2A CDC73 TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 TAF15 GTF2H2 LEO1 TAF12 GTF2H3 TAF13 SUPT5H PAF1 GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 TAF10 SUPT6H IWS1 EAF1 EAF2 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%110362 POLB-Dependent Long Patch Base Excision Repair LIG1 FEN1 PARP1 PARP2 POLB PARG APEX1 ADPRS FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 95%400451 Free fatty acids regulate insulin secretion GNA14 GNAQ CD36 GNA15 PLCB3 PLCB1 FFAR1 PLCB2 ACSL4 ACSL3 GNA11 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 95%9937008 Mitochondrial mRNA modification RCC1L RPUSD4 NGRN RPUSD3 TRMT61B TRUB2 MTERF3 SLIRP MTPAP FASTKD2 LRPPRC INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 CDC42 RAC1 SRGAP2 SRGAP3 ARHGAP39 SRGAP1 SLIT2 ROBO1 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 95%110320 Translesion Synthesis by POLH RFC5 PCNA UBC RFC3 RFC4 RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 NPLOC4 POLH RPA3 VCP SPRTN UFD1 UBB DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 95%5609978 Defective GALT can cause GALCT GALT SOMITOGENESIS%REACTOME DATABASE ID RELEASE 95%9824272 Somitogenesis TBX6 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 LEF1 PSMD11 PSMD14 PSMD13 PSMA7 CTNNB1 PSMB6 PSMB7 PSMB4 PSMB5 MESP2 DLL3 PSMB2 HES7 PSMB3 MSGN1 RBPJ RIPPLY2 PSMB1 LFNG ADRM1 EPHA4 PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 NOTCH1 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.3 Signaling by FGFR2 in disease SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F PIK3R1 POLR2G POLR2H NRAS PLCG1 POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 PIK3CA NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription CREBBP FLT4 RBPJ MAML2 MAML1 SMAD3 KAT2B HEY1 KAT2A ACTA2 HES1 SNW1 EP300 HEY2 HES5 MAMLD1 MAML3 NOTCH2 NOTCH1 NOTCH4 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RELA MAP3K7 PIK3R2 PIK3R1 NFKB1 CDC34 CHUK IKBKB CARD11 MALT1 NFKBIA UBE2D2 PSMD8 PSMD6 PTEN PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 TRAC PSMA2 INPP5D CD3G TRAT1 CD3E TRAF6 CD3D UBA52 TRBV12-3 PSMD12 TRAV29DV5 PSMD11 TRBV7-9 BCL10 TRBC1 PSMD14 BTRC HLA-DQA2 PSMD13 HLA-DQA1 HLA-DPA1 PSMA7 HLA-DRB5 TRAV19 PSMB6 HLA-DRB4 PSMB7 HLA-DPB1 PSMB4 TRAV8-4 HLA-DRA PSMB5 IKBKG CD4 HLA-DRB3 UBB HLA-DRB1 RIPK2 HLA-DQB2 PSMB2 PIK3CB PSMB3 HLA-DQB1 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 LCK SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 PDPK1 TAB2 PRKCQ PIK3CA UBE2N CUL1 SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription JUN HDAC1 HDAC3 KDM1A MAPK1 MBD3 MAPK3 ATF2 EGR1 GATAD2B GATAD2A RPTOR MLST8 CHD3 SLC38A9 BMI1 CBX6 RING1 HDAC2 MTOR RNF2 RRAGA RRAGC SUZ12 CBX8 PHC2 RHEB RRAGB PHC1 NR2E1 RRAGD CBX4 CHD4 LAMTOR2 CBX2 LAMTOR1 PHC3 SNAI2 LAMTOR4 LAMTOR3 LAMTOR5 MECOM RCOR1 ATN1 EED SALL4 MAF1 HDAC5 MTA2 HDAC7 RBBP4 EZH2 MTA1 REST MTA3 RBBP7 SNAI1 TP53 PPARG CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 95%9707564 Cytoprotection by HMOX1 RXRA CYCS PTK6 COX5B COX5A STAT3 COX6C HBB HDAC3 SIN3A COX4I1 COX4I2 BLVRB TBL1X COX6A1 BLVRA NCOA1 COX6A2 FABP1 MT-CO1 NLRP3 COX6B2 COX6B1 NCOR2 COXFA4 COX7A2 NCOR1 COX7A1 TBL1XR1 HIGD1C ABCC1 ALB HBA2 TXNIP HMOX1 MT-CO2 MT-CO3 HM13 HMOX2 NCOA2 NCOA6 SMARCD3 CARM1 BACH1 HELZ2 CREBBP CHD9 MAFK NFE2L2 MED1 TGS1 STAP2 COX7A2L COX7B COX7C COX8A COX8C PPARA PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNG CHRNE CHRNA6 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 95%210991 Basigin interactions ITGA3 ITGA6 ATP1B3 PPIL2 ATP1B2 ATP1B1 SLC16A8 MMP1 SPN SLC16A3 SLC3A2 SLC7A11 SLC7A10 SLC16A1 MAG PPIA BSG SLC7A5 SLC7A6 ITGB1 SLC7A7 CAV1 L1CAM SLC7A8 SLC7A9 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE PLA2G4C GPCPD1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020933 Interleukin-23 signaling TYK2 IL23R STAT4 JAK2 IL12B STAT3 IL23A IL12RB1 P4HB DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME%R-HSA-9734195.2 Defective APRT disrupts adenine salvage APRT DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function RDH12 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2CB PFKFB2 PRKACG PFKFB1 PFKFB4 PRKACA PFKFB3 PPP2R5D PRKACB PPP2R1B PPP2R1A BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 95%9018676 Biosynthesis of D-series resolvins HPGD ALOX5 LTA4H RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RHOC H2AC20 RHOA RHOB KDM1A PPP1R12B PPP1R14A KLK3 KLK2 KDM4C YWHAB YWHAE MYL9 YWHAQ YWHAG AR YWHAH PKN3 YWHAZ SFN NCOA2 CDC25C PKN2 PKN1 PPP1CB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 PPP1R12A H2AC6 H2AC7 PAK1 RAC1 H2BC17 MYL12B H2BC12 MYL6 H2BC13 MYH9 H2BC14 MYH14 H2AJ MYH11 PDPK1 H2BC15 MYH10 H2BC11 H3C15 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis UBC PGM1 GYG1 RPS27A GBE1 UBA52 GYS1 GYS2 UGP2 GYG2 EPM2A PPP1R3C NHLRC1 UBB APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 95%174048 APC C:Cdc20 mediated degradation of Cyclin B ANAPC16 ANAPC7 UBE2C UBC UBE2E1 UBE2D1 RPS27A ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC20 UBB ANAPC15 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions CACNA1D NCAM1 COL4A2 GFRA1 COL4A1 GFRA2 GFRA4 NRTN CACNA1C CACNA1S PSPN COL6A2 COL4A4 COL6A1 GDNF COL4A3 CACNB1 CACNB3 COL6A3 CACNB4 COL9A1 COL4A5 COL9A3 CNTN2 COL6A6 COL9A2 ST8SIA4 COL6A5 AGRN NCAN CACNA1H ST8SIA2 CACNA1G CACNA1I CACNB2 PRNP ARTN GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling GP5 YWHAZ GP9 RAF1 PIK3R1 VWF FLNA GP1BA GP1BB SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193368.4 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol RXRA ACOX2 ABCB11 NCOA2 AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 ACOT8 BAAT HSD3B7 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall IGHV3-23 IGLV IGLV2-8 SELP IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 SLC16A8 IGKV1D-39 PECAM1 SLC16A3 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 SLC16A1 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 APOB IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 IGLC1 PPIL2 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 MMP1 IGKV1-33 SLC3A2 IGLC7 SLC7A11 IGHV3-53 SLC7A10 EPCAM IGKV5-2 IGLC6 IGKV1-5 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 SDC1 LYN INPP5D DOK2 GP6 PF4 MIF PPIA CAV1 ITGA3 JAM2 ITGA6 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 OLR1 SPN VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 PSG9 FCAMR PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD ANGPT4 ANGPT2 MERTK CD2 CD244 PLCG1 ITGAM ITGB2 PIK3CB F11R HRAS SIRPG GRB7 PIK3CA ITGB3 ITGB1 L1CAM ITGAV ITGA5 SOS1 TNFRSF10B SHC1 TNFRSF10A PIK3R2 PIK3R1 TNFRSF10D NRAS ITGAX FCER1G ITGAL CEACAM3 CEACAM6 PTPN11 CEACAM8 CD47 TSPAN7 CD44 ITGA4 CD58 PICK1 SIRPA SELL TREM1 PTPN6 CEACAM1 YES1 LCK FYN PROC BSG PROS1 F2 IGHA1 GAS6 IGHA2 JCHAIN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.6 Activation of RAC1 SOS1 NCK2 SOS2 NCK1 SLIT2 ROBO1 PAK6 PAK1 PAK3 RAC1 PAK5 PAK2 PAK4 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME%R-HSA-9839406.1 TGFBR3 regulates activin signaling ACVR2A INHBA INHA TGFBR3 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 95%9008059 Interleukin-37 signaling PTPN7 PTPN5 IL18R1 PTPN2 PTPN4 SIGIRR SMAD3 STAT3 TBK1 PTPN6 PTPN13 PTPN20 PTPN23 IL18BP CASP1 PTPN18 IL37 PTPN12 PTPN11 PTPN14 PTPN9 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013408 RHOG GTPase cycle ERBIN MPP7 VANGL1 ARHGAP32 RHOG ARHGEF5 PIK3R1 ESYT1 ARHGEF26 KALRN ELMO2 MCF2 CDC42 DOCK5 DOCK4 ARHGDIG ANKLE2 DOCK3 ARHGDIA SHMT2 LAMTOR1 NDUFS3 CYFIP1 DOCK2 DOCK1 TFRC PLD1 IQGAP2 STX5 ARHGAP1 HSPE1 ARHGAP39 LETM1 ARHGAP5 ARHGAP35 OPHN1 STBD1 ARHGDIB MAP3K11 EMD LBR TMPO PLEKHG3 VRK2 LEMD3 DEPDC1B ARFGAP3 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 TRIO ITSN1 ARHGAP21 PREX1 LMAN1 MCF2L PGRMC2 NDUFA5 VAV3 VAPB KTN1 PAK2 YKT6 ARHGEF16 PAK4 DIAPH3 ITGB1 VAV1 VAV2 CAV1 MCAM REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 95%400206 Regulation of lipid metabolism by PPARalpha MED19 ABCB4 MED18 SREBF2 MED11 MTF1 MED9 MED29 MED28 MED22 APOA2 MED21 APOA1 APOA5 CDK19 MED13L ANGPTL4 ESRRA CDK8 RORA RGL1 GLIPR1 ANKRD1 ACADM SMARCD3 CARM1 CYP4A11 CYP1A1 CYP7A1 TXNRD1 SLC27A1 EP300 SULT2A1 MED1 MED30 MED31 GRHL1 ACSL1 MED8 MED4 MED6 MED7 TIAM2 TRIB3 RXRA HMGCS2 HDAC3 ARNT2 GPS2 NFYA NR1D1 SIN3A RXRB NFYB NFYC TBL1X BMAL1 NCOA1 ABCA1 FABP1 NR1H2 NR1H3 ARNT NCOR2 NCOR1 TBL1XR1 AHRR THRAP3 NR1H4 PEX11A G0S2 AGT AHR FAM120B FADS1 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NRF1 CPT2 ME1 PLIN2 CPT1A CLOCK NPAS2 HELZ2 MED16 MED15 CREBBP MED17 SP1 CHD9 MED12 ALAS1 MED14 FHL2 MED13 MED10 TGS1 TNFRSF21 MED27 MED26 MED23 MED25 MED24 MED20 FDFT1 PPARG UGT1A9 HMGCS1 PPARA MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME DATABASE ID RELEASE 95%174490 Membrane binding and targetting of GAG proteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RELA DDX5 NPM1 ITCH VCP NLRP3 ACE2 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 MAVS TKFC RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI PARP10 PARP6 SFTPD GSK3A PARP4 PARP16 YWHAQ PARP9 PYCARD PARP14 YWHAG PARP8 YWHAH UVRAG MAP1LC3B PPIB TRAF3 TRAF6 RB1 BECN1 TLR7 RIPK3 TMPRSS2 RPS4Y2 KPNB1 RPS27L GALNT1 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 CHMP4C HNRNPA1 RPS10 CHMP4B EP300 RPS13 CHMP4A RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RUNX1 CHMP2B RPS3A RPS26 CHMP2A EEF1A1 RPS25 RPS28 RPS29 PDPK1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 PIK3C3 CHMP3 CHMP6 CHMP7 PIK3R4 NFKB1 BST2 PRKCSH GANAB MGAT1 MOGS PCBP2 CANX UBE2I SUMO1 YWHAB FKBP1A ST6GALNAC2 TRIM25 CASP1 IKBKE SIKE1 VHL GSK3B ST6GAL1 SFN YWHAZ UBA52 ST6GALNAC3 ST6GALNAC4 IFIH1 UBB TOMM70 UBC SP1 ST3GAL4 RPS27A BCL2L1 ZCRB1 ST3GAL1 ST3GAL2 ST3GAL3 PPIA IRAK2 PSMC6 KPNA2 CTSL PPIH PPIG CAV1 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 95%418886 Netrin mediated repulsion signals DCC UNC5A NTN1 UNC5B SRC UNC5C PTPN11 UNC5D REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 95%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBC RPS27A TICAM1 TLR3 TBK1 TRAF3 IKBKE OPTN UBA52 TANK UBB PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%5205685 PINK1-PRKN Mediated Mitophagy MAP1LC3A VDAC3 ATG5 VDAC2 TOMM20 ATG9A VDAC1 UBE2L3 MAP1LC3B ATG12 TOMM7 UBA52 MFN1 TOMM5 MFN2 TOMM6 TOMM22 UBB TOMM70 SQSTM1 UBC RPS27A TBK1 UBE2V1 PRKN OPTN TOMM40 UBE2D2 UBE2D3 MTERF3 PINK1 UBE2N VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%199220 Vitamin B5 (pantothenate) metabolism FASN PDZD11 SLC5A6 PANK4 VNN1 PANK2 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP1 ENPP2 ENPP3 SLC25A42 AASDHPPT RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.4 Rab regulation of trafficking RAB14 RAB27B TRAPPC4 RAB9A RAB6B RAB9B RAB39A YWHAE MAP1LC3B RAB33B RAB31 RAB5B RAB5C RAB3IP RAB11A RAB6A ARF6 RAB1A TRAPPC1 RAB1B RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 SYTL1 GAPVD1 RIC1 RAB32 RAB35 TBC1D24 RGP1 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB3GAP2 TRAPPC2L DENND6A RAB10 RIN1 TBC1D20 RIN2 RAB3GAP1 GABARAP TBC1D13 RAB18 TBC1D14 TBC1D17 TRAPPC2 TBC1D15 TBC1D16 TRAPPC3 ANKRD27 TBC1D10C DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B TRAPPC8 MON1A MON1B TRAPPC6A DENND1C TRAPPC6B DENND1B GDI1 ULK1 DENND1A RAB8B DENND2D TRAPPC10 DENND2C DENND2B DENND2A RAB3IL1 RAB33A TBC1D2 GDI2 RABEP1 TBC1D3 TBC1D7 RAB7B RABGAP1 DENND3 RAB21 ALS2CL CHML RAB11B RAB12 RAB13 CHM GGA2 GGA1 GGA3 TSC2 TSC1 AKT1 ALS2 RAB3A RAB4A RAB7A OPTN RAB27A RAB8A AKT3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation EOMES FGFR1 SNAI1 TBXT SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 95%427359 SIRT1 negatively regulates rRNA expression SUV39H1 H2BC9 H2AZ2 H4C9 H2BC8 TBP TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 RRP8 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 H2BC11 H3C15 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.7 Transcription from mitochondrial promoters POLRMT TFAM MTERF1 TFB2M G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition CEP41 TUBGCP4 CEP43 CDC25A TUBA1A PRKACA LIN54 LIN37 LIN9 PKMYT1 FOXM1 WEE1 LIN52 YWHAE TUBB4B TUBB4A MYBL2 YWHAG HSP90AA1 CDC25C AURKA FZR1 BTRC RBBP4 PPP2R1B PPP2R1A CPAP SGO1 EP300 PRKAR2B TPX2 DYNLL1 CDKN1A CKAP5 HSP90AB1 CDC25B CDK2 MAPRE1 FBXL18 FBXL7 PAFAH1B1 DYNC1I2 PPP2CA PPP2CB CLASP1 DYNC1H1 NDE1 CENPF CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 AJUBA PSMD3 PSMD1 CCNH PSMA5 PLK1 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PSMD12 PCM1 PSMD11 CDK1 CNTRL CEP250 NEK2 PSMD14 CEP290 PSMD13 NINL CDK5RAP2 OFD1 PSMA7 CEP135 TUBB PSMB6 CEP131 CDK7 HAUS4 PSMB7 HAUS3 PHLDA1 CSNK1D PSMB4 MNAT1 HAUS6 PPP1CB HAUS5 PSMB5 CSNK1E UBB TUBG2 TUBG1 PSMB2 HAUS2 PSMB3 HAUS1 HJURP UBC MZT2B PPP2R2A MZT2A PSMB1 PPME1 NME7 GTSE1 AKAP9 RPS27A BORA CEP63 FKBPL SFI1 FBXW11 SDCCAG8 OPTN DCTN2 OBI1 TUBGCP2 HMMR SSNA1 ADRM1 MIS18BP1 DCTN3 RAB8A HAUS8 PPP1R12A HAUS7 PSMC5 CEP70 LCMT1 PSMC6 CEP72 SEM1 PPP2R3B PSMC3 CEP192 TICRR PSMC4 TUBA4A PCNT PSMC1 CEP76 PSMC2 CEP78 PLK4 SKP1 CDK11A TP53 CCNB2 ODF2 CCNA2 CCNA1 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 CUL1 TUBGCP6 TUBGCP3 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRND CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNG CHRNA6 CHRNE EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.2 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 95%9636667 Manipulation of host energy metabolism ENO1 PGK1 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 95%73942 DNA Damage Reversal MGMT ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 95%2555396 Mitotic Metaphase and Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 FBXO5 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9640463 Wax biosynthesis FAR2 AWAT1 AWAT2 FAR1 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 95%5689603 UCH proteinases YY1 RUVBL1 H2AC20 TGFB1 H2AC1 TGFBR1 TGFBR2 KDM1B INO80C INO80B INO80E INO80D SMAD7 OGT PSMD8 PSMD6 H2AC17 H2AC12 PSMD7 PSMD2 PSMD3 NFRKB SENP8 PSMD1 HCFC1 ACTR5 PSMA5 PSMA6 PSMA3 ACTR8 PSMA4 PSMA1 PSMA2 UBA52 INO80 PSMD12 PSMD11 PSMD14 H2AC25 H2AC21 USP15 PSMD13 BAP1 PSMA7 PSMB6 FOXK2 PSMB7 UCHL1 FOXK1 PSMB4 PSMB5 ACTB UBB TFPT PSMB2 ACTL6A PSMB3 BARD1 UCHL3 UBC H2AC19 PSMB1 UCHL5 H2AC14 RPS27A ASXL1 NEDD8 ADRM1 H2AC8 ASXL2 H2AC6 PSMC5 H2AC7 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MBD5 PSMC2 MBD6 MCRS1 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling JUN IGF2BP1 MAPK6 MAPK4 KALRN DNAJB1 PRKACG PRKACA PRKACB CDC42 TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 TNRC6A TNRC6B HSPB1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 NCOA3 PSMA2 CDC14A UBA52 PSMD12 PSMD11 CDK1 CCND3 PSMD14 PSMD13 MAPKAPK5 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDC42EP5 RPS27A CDC42EP3 CDC42EP2 FOXO1 ADRM1 PSMC5 PAK1 PAK3 PSMC6 RAC1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SEPTIN7 CDC14B FOXO3 PAK2 RAG2 RAG1 ETV4 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.6 p53-Dependent G1 DNA Damage Response CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461973 Defensins DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFB105B DEFA1B DEFB1 DEFB104B DEFA6 DEFB109B DEFA4 DEFA5 DEFB136 DEFB135 DEFA3 DEFB134 CCR6 DEFB133 DEFB132 PRSS3 DEFB108B DEFB108C PRSS2 CCR2 CD4 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 UREA CYCLE%REACTOME%R-HSA-70635.4 Urea cycle CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC TP53 ARG2 SLC25A2 SIRT5 SLC25A15 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 95%388396 GPCR downstream signalling TAS2R10 TAS2R13 TAS2R14 ADCY9 TAS2R16 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A ITPR1 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP TAS2R38 PDE11A PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 GPR183 PNOC GPR18 SSTR3 PTH1R GPR37 PDE10A GPR31 PTH2R GPHA2 GNAS GPR55 GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 TAS2R42 TAS2R45 CRHR1 PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW TRIO RASGRF2 ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 VAV3 HCAR1 ARHGEF11 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ ARHGEF15 PLEKHG5 HEBP1 ARHGEF17 GRM3 ARHGEF16 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A AGT GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP APP F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 RGSL1 GRPR CYSLTR1 CCL1 EDNRA CCL19 EDNRB PROK2 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 GPR17 ACKR3 NMB CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK ADORA1 HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HBEGF HRH2 HRH4 DRD1 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA PAK1 C3 ROCK1 ROCK2 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-1266738.19 Developmental Biology NR5A1 CLTB YAP1 RELA WNT1 PERP ARPC1B ARPC1A ARPC4 ARPC5 MAMLD1 SLC2A2 ARPC2 ARPC3 IHH ACTR3 ACTR2 CNOT10 CNOT11 TCF3 YWHAE LDB1 LEP DPY30 CHD4 YWHAG CSF1 YWHAH EED MTA2 CARM1 DAG1 MMP2 MAML2 MAML1 TRIO ITSN1 MED1 RAC1 MED8 VAV3 ARHGEF11 MED4 ARHGEF12 MED6 MED7 PRKCQ MAML3 CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 NKX2-5 ARHGEF7 SOS2 NGEF KALRN RET RARG ASH2L TFAP2A TFAP2B TFAP2C UBE2I TNKS1BP1 SUMO1 TEAD1 TEAD2 TEAD4 HIF3A ELOB TCF12 ELOC RBX1 RARB AJUBA EPAS1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C POLR2A PLXNA3 POLR2B LCE1A POLR2C LCE1B POLR2D LIPJ POLR2E LIPN POLR2F LIPM POLR2G PRSS8 POLR2H LIPK POLR2I POLR2J KRT4 POLR2K KRT3 POLR2L KRT2 KRT1 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 ACTB LORICRIN KRTAP20-1 KRTAP20-2 FLG SPRR2E SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 PPL EVPL CSNK2A1 KRT33B KRTAP5-10 KRT33A CSNK2A2 KRTAP5-11 SPRR2A SPRR2B SPRR2D CSNK2B ST14 CDSN KRTAP16-1 KRTAP8-1 TP53 SPRR1A SPRR1B KRTAP26-1 KRT24 KRT23 KRT20 CASP14 LCE5A KRT28 SOX17 KRT27 SRY KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP15-1 ABL1 KRTAP9-2 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 PLAC8 KRTAP9-8 KRT39 KRT38 KRT37 LCE6A PLXNA4 MAP2K6 KRT36 IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B CNOT4 KRTAP2-4 CDK8 KRTAP2-3 KRTAP2-2 CNOT6 KRTAP2-1 CNOT7 KRT13 KLK13 CDK5 CNOT1 KRT12 KLK14 CNOT2 CNOT3 KRT10 LCE3E KLK12 KRT19 CNOT8 KRT18 KRT17 CNOT9 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 TGM5 KRTAP3-1 WDR5 KRT6C KRT6B RPTN ZNF521 KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KAZN KRT78 KRT77 KRT76 SMARCD1 KRT75 SMARCD2 KRT74 SMARCD3 KRT73 KRT72 PKP2 SPINK9 PKP3 DSC1 DSC2 DSC3 RBBP4 KRTAP23-1 RBBP5 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 PTPRC LELP1 RBBP7 KRTAP4-1 ACTG1 KRTAP12-1 KRTAP12-3 KRTAP12-2 SMARCE1 KRTAP4-9 KRTAP4-8 KRTAP12-4 KLF4 KRTAP4-7 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 PFN1 KRTAP11-1 CELA2A SOX2 PFN2 KRTAP5-9 KRTAP5-8 KRTAP5-7 NFASC KRTAP5-6 KRTAP5-5 KRTAP5-4 SOX9 KRTAP19-2 KRTAP19-1 RUNX3 SRGAP2 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DIAPH1 DSG4 RPS27 KRT82 KRT81 ITGB1 KRTAP21-2 KRT80 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 RHOC KRTAP10-4 KRTAP10-7 KRTAP10-6 KRTAP10-9 KRTAP10-8 RHOA KRTAP6-3 RHOB KRTAP21-1 EVL SRF CDK5R1 CDC42 COX7A1 CLASP1 CLASP2 KDM5B ARID1A ARID1B TYROBP IFNG ERBB2 HES1 POMC MARK3 MMP9 NCBP1 NRP2 NCBP2 TLN1 CNTN2 NRCAM ANK1 IRX1 LFNG IRX2 JAG1 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 FYN POU3F3 WNT4 MCM5 MCM2 CLTC CYP51A1 SREBF2 CLTA AP2A1 VLDLR AP2A2 CDON AP2M1 PBX1 RAP1GAP PRKACG PRKACA PRKACB CCL3 ANGPTL4 LPL AP2S1 CXCL12 DICER1 AP2B1 TRPM1 PAX3 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP LAMA5 LAMA2 SH3KBP1 PXN LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN NUMB UCP1 MTA1 PRDM16 ZNF423 ENAH MTA3 RPS4Y2 EBF2 RPS27L BMP7 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 GMPR RPS3 MYO10 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 PPP3CB RPS25 MYH14 RPS28 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 WNT11 NOTCH1 CACNA1D GCK NFATC1 NANOG HSP90AB1 RDX NAB1 NAB2 DNM2 SIAH1 EGR2 EPRS1 ID1 EIF4E ID4 EIF4B ZFPM2 EPHB6 EFNB2 ARHGAP39 EFNB1 EFNB3 EPHB2 EPHB1 ARHGAP35 EPHB4 EPHB3 ITGA10 FOXH1 ACVR1B WNT3A ACVR2B GIT1 ACVR2A DRAP1 ACVR1C DSG2 EPHA2 PAK1 ABL2 PAK2 PAK4 POU5F1 TGFB1 CNTN1 FOXC2 FOXC1 SIX1 HOXD11 NPNT HOXC11 HIRA PAX2 HOXA11 GREM1 SALL1 SIX2 DSCAM DCC DSCAML1 NTN1 STX1B TNFSF11 SRGAP3 SRGAP1 JUP FGFR1 WASL IAPP PAK6 PAK3 PAK5 MYO9B TPST2 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 SERPINE1 RPL4 RPL5 RPL30 RPL3 ITGA2 RPL32 RPL31 RPLP1 ITGA8 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 CTCF RPLP2 FABP4 HOXA3 RPL35 COL9A1 RPL38 HOXA1 PKNOX1 COL9A3 RPL37 PRL COL9A2 HOXA4 AGRN PIAS2 RPL39 RPL21 HOXB4 CHD3 RPL23 HOXB3 RPL22 HOXB2 HOXB1 RPL13A HOXD1 RPL9P9 HOXC4 RPL37A RPL24 MEIS1 RPL27 MAFB RPL26 HOXD4 HDAC2 DPF1 RPL29 HOXD3 RPL28 ZNF335 DPF2 RPL10 RPL12 DPF3 RPL11 RPL36A SUZ12 RPL14 PAXIP1 RPL13 RPL15 RPL18 RPL17 RPL19 PCGF2 RPL39L SS18L1 RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 CD36 NCOA2 SS18 NCOA6 NCOA3 TET3 SHH DHH ADIPOQ CREBBP EYA1 BCL2 NTN3 AREG CDH4 BNIP2 TNF CTNNA2 MYOG EBF1 WNT10B SPAG9 MEF2B NR2F2 MYOD1 ADIRF PAGR1 MYF6 SLC2A4 ZNF638 TCF4 BCL7A CEBPD CDH15 ZNF467 BCL7C MYF5 BCL7B FOXA1 KDM6A TGFA FOXO3 ABLIM1 ABLIM2 PTK2 ABLIM3 AKT3 JUN MED19 UHRF1 MED18 MED11 MED9 MED29 MED28 MED22 MED21 CDK19 MED13L ETF1 GSPT2 GSPT1 ASAH1 GSC MIXL1 UPF3A UPF2 UNC5A UNC5B CIDEA CAP2 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 MC4R DARS1 EEF1E1 MC3R KARS1 IARS1 PKP1 MC5R SDCBP DSP DSG1 DSG3 MAPK7 APH1A ZIC1 FOXD3 PSENEN NCSTN TFE3 APH1B MITF CLTCL1 PSEN2 TFEC ADAM10 ALX3 TBX3 PSEN1 DNM1 SDC2 STT3B GPC1 MAG PRDM14 CRIPTO SHC3 LIN28A ZIC3 ZSCAN10 DNM3 MAPK12 GATA3 LYN SIAH2 RPLP0 PITPNA CFL1 STAT4 IL12RB2 ACTL6A MSN PIK3CD KAT2B KAT2A MEF2A FGF8 RPS6KA3 SOX1 GBX2 RPS6KA5 RPS6KA2 OTX2 TBX6 RPS6KA1 POU3F1 YY1 ITGA1 LEFTY1 CRIPTO3 ONECUT3 DAND5 ONECUT1 CFC1 CER1 PDX1 NKX6-1 NODAL PTF1A PAX6 ISL1 PTGDS FOXO4 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD1 SMAD4 SMAD3 NEUROG3 LGI1 LGI4 LGI3 LGI2 ADAM22 ADAM11 ADAM23 USP33 SNAI2 FOXA2 NEUROD1 NKX2-2 PAX4 HNF1A MAFA RFX6 INSM1 FOXA3 FARP2 PLXND1 PKP4 PLXNA1 IRS2 PIK3CB PLXNB1 FGF2 NCK2 FGF4 NCK1 FGF7 MESP1 FGF9 AKT2 GATA6 TBXT GRB10 ATP6V1E1 TBX20 SMYD1 TBX1 EOMES HRAS ATP6V1G1 MYOCD HAND1 ATP6V0B ATP6V0E1 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 HNRNPU SPTBN1 ATP6V0D1 SOS1 ATP6V0C MAGOH ATP6V1A SHC1 PIK3R2 PIK3R1 INS NRAS ATP6V1H MAPK1 ATP6V1C1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 FGF10 UPF3B MAGOHB SNW1 SRC RNPS1 SHANK3 GRIN2B THRAP3 GRIN1 RND1 DLG1 DLG3 TBPL2 DLG4 MBP EMX2 FAM120B ADGRV1 PCDH19 DOCK1 WFDC2 MECOM MSX1 MPZ OSR1 PLK1 ADGRG6 ZIC2 HMGCR TBX21 SALL4 CCNB1 HOXA6 PAX8 PAX7 AMH GDF1 PRX NOG CTNNA1 DMRT1 NOTO PMP22 FOXF1 SOX10 BRCA1 ZEB2 CASC3 SNAI1 RANBP9 KAT5 GXYLT2 CDH2 POU3F2 SYTL2 PMEL TERT MYO5A RAB27A TYR EDIL3 MYRIP CEACAM1 ZEB1 DCT IRF4 SEM1 PXDN BIRC7 BCL2A1 TYRP1 MLANA USF1 MLPH RBM8A CXCR4 EDNRB KIF4B KIF4A CAP1 EDN1 EDN3 LEFTY2 PABPN1 PI3 CAPNS1 CAPN1 SCD5 ELOVL3 KIT BMP4 TCF7L2 CDKN1A ALCAM TCF7L1 SCN11A HDAC1 HOXA2 CDKN2A UNC5C LEF1 UNC5D TCF7 CDC25B SCN10A AGAP2 TBX2 FLRT3 HINT1 CCND1 CHL1 LYPLA2 SIN3A ZSWIM8 CDK2 MSI1 CTNNB1 COL6A2 MET PLXNC1 SEMA6A COL4A4 SEMA6D CEBPB SEMA7A COL6A1 GPR143 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 LHX4 COL6A3 LHX9 RBPJ CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB TNRC6C COL6A5 MOV10 NTN4 STX1A SEMA3E MEF2C AGO3 SEMA4A AGO4 NELL2 CDH1 RPS6KA4 SCN1B MYC AGO1 SCN1A AGO2 EPHA5 EPHA4 TNRC6A EPHA7 TNRC6B EPHA6 YWHAB EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 XPO1 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B AKT1 SCN3A PSMD1 PRNP SPTBN2 GATA4 ARTN CD24 SCN2A SCN2B PRKCA ROBO2 YWHAZ GFRA1 PSMA5 GFRA3 PPARGC1A PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 RGMA PPARGC1B PSMA1 GFRA4 RELN PSMA2 CD72 SCN9A PABPC1 NRTN DOK2 UBA52 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C EFNA5 PSMD13 EFNA4 SPTA1 EZH2 PSMA7 CACNA1S PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX MED16 PSMB2 SCN4A MED15 PSMB3 SCN4B MED17 SLIT1 SCN7A UBC MED12 PSMB1 SLIT3 MED14 PDLIM7 MED13 RPS27A HEY1 MED10 HSPA8 HEY2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 CACNA1H PSMC2 MYL12A MED27 SIRT1 CACNA1G MED26 CACNA1I EIF4G1 MED23 MED25 MED24 MED20 PPARG PPARA DRP2 FURIN PCSK6 ROCK1 ROCK2 UTRN MBD3 GATAD2B GATAD2A NCAN RPS6KA6 HSP90AA1 EGF EGFR PLCG1 CCND3 E2F1 TFDP1 TFDP2 CDK4 KMT2D H2AX CSF3R SPI1 GFI1 LIG1 H2AB1 DLX5 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 FOXO1 DOK1 MYB EP300 IL6R RASA1 H3-3B H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 BTG4 RUNX1 EIF4A2 H2BC12 H2BC13 KDM5A EIF4A1 H2BC14 TUT7 H2AJ TUT4 H2BC15 DUX4 TAL1 H2BC11 PABPN1L RARA TPRXL DUXA CEBPA KMT2A DUXB DIS3L2 CBFB CEBPE KDM6B GATA2 PRM2 H3C15 PRM1 RXRA STPG4 H2BC9 METTL23 H2AZ2 DPPA4 DPPA3 H4C9 H2BC8 DPPA2 H2BC5 ZFP36L2 H2BC3 LEUTX STAT3 PAIP1 NPM2 H2BC1 NFKB1 KDM4E DEK FLI1 TPRX1 AICDA KLF5 H2AC20 SRPK1 H1-8 TPRX2 HDAC3 ZSCAN4 TBL1X PCK1 NCOA1 NCOR2 NCOR1 HAND2 TBL1XR1 SLIT2 PLIN1 ROBO1 SEMA5A AKAP5 TBX5 CACNG8 CACNG2 CACNG3 CACNG4 TRIM33 SMARCB1 CCNC SMARCC1 SMARCC2 HELZ2 CHD9 ST8SIA4 TFEB SH3GL2 WWTR1 YES1 TGS1 MEF2D SMARCA2 SMARCA4 ST8SIA2 HNF4G DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 95%4793950 Defective MAN1B1 causes MRT15 MAN1B1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR SOS1 HBEGF SHC1 ARHGEF7 PIK3R1 NRAS STAM2 ADAM10 ADAM12 PTPRK EPS15L1 EPN1 PTPN11 SPRY1 PTPN3 CDC42 FAM83B ADAM17 SRC LRIG1 SH3KBP1 PXN EGF CBL EGFR UBA52 PLCG1 STAM CSK HGS PTPN12 UBB PAG1 UBC RPS27A FAM83D SH3GL3 AREG FAM83A EPS15 SH3GL2 SH3GL1 AAMP SPRY2 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN GSD IV%REACTOME DATABASE ID RELEASE 95%3878781 GSD IV GYG2 GBE1 GYS2 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication ORC4 PPP2CA ORC6 PPP2CB ORC1 ORC3 ORC2 CCNB1 RB1 CDK1 PPP2R3B E2F1 MCM8 TFDP1 TFDP2 PRIM2 PRIM1 POLA1 PPP2R1B ORC5 POLA2 PPP2R1A NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.3 Nuclear Receptor transcription pathway RXRA NR5A1 NR2C2 PPARD NR2C1 NR2C2AP RXRG NR2F1 NR0B2 NR2F6 NR1D2 RXRB NR1D1 ESRRA RARG ESRRB ESRRG NR1H2 NCOR2 NCOR1 ESR1 VDR ESR2 HNF4A MED1 NR4A2 NR4A1 RORC THRB RORA THRA RORB NRBP1 HNF4G NR2E1 RARB RARA PGR PPARG AR PPARA RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME SLC29A1 ADK SLC29A3 NME1 NT5C2 SLC28A3 NME2 PNP ITPA ADA SLC28A2 SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PLD6 PLD2 PLD1 PLD3 PGS1 CDS2 PTPMT1 PLD4 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2E1 CYP2C9 CYP2C8 CYP1A2 CYP3A4 CYP2D6 RHOF GTPASE CYCLE%REACTOME%R-HSA-9035034.5 RHOF GTPase cycle FAM169A ADD3 AKAP12 SNAP23 VANGL1 ARHGAP1 ARHGAP32 SLC4A7 ARHGAP39 PIK3R2 ARHGAP5 PIK3R1 RHOF ESYT1 SYDE1 BAIAP2L1 ACTN1 POTEE LMNB1 TMPO BASP1 ACTB TOR1AIP1 ARHGAP12 DEPDC1B CAPZB VAMP3 RAB7A STEAP3 DIAPH2 ARHGAP21 SOWAHC FARP1 MYO9B SRGAP2 MTMR1 BAIAP2L2 SENP1 DIAPH1 DIAPH3 CAV1 MCAM DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 95%9675151 Disorders of Developmental Biology ASH2L NCOR2 NCOR1 TBL1XR1 HDAC1 HDAC3 CAMK4 GPS2 SIN3A RBBP5 PRKACA DPY30 TBL1X WDR5 CALM1 KMT2D IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%9709275 Impaired BRCA2 translocation to the nucleus SEM1 BRCA2 COMPLEX III ASSEMBLY%REACTOME%R-HSA-9865881.2 Complex III assembly UQCRFS1 BCS1L UQCRH LETM1 TTC19 UQCRHL FXN LYRM4 HSCB LYRM7 UQCRC1 UQCRC2 UQCC3 UQCC2 UQCC1 CYC1 UQCC6 UQCC5 UQCR11 UQCR10 UQCRQ HSPA9 UQCRB MT-CYB RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%73772 RNA Polymerase I Promoter Escape H2BC9 H2AZ2 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A H2AC20 RRN3 CBX3 CCNH TBP POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 UBTF H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine GLYATL3 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 95%110357 Displacement of DNA glycosylase by APEX1 MBD4 MPG SMUG1 OGG1 NTHL1 APEX1 TDG REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 95%9759476 Regulation of Homotypic Cell-Cell Adhesion ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 HEYL SPCS3 SPCS2 SPCS1 ANGPTL4 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PRDM8 CTNND1 UBA52 BHLHE22 CDH8 PSMD12 ZC3H12A PSMD11 CTNNA1 PSMD14 CDH24 HOXC8 PSMD13 FOXF1 CSNK2A3 ADAM33 SOX10 EZH2 PCSK7 PSMA7 ADAM19 ILF3 PSMB6 MPHOSPH8 ZEB2 CDH11 PSMB7 SNAI1 CDH19 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8939902 Regulation of RUNX2 expression and activity NR3C1 ESRRA STAT1 NKX3-2 MSX2 ESR1 SMURF1 BMP2 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B PSMA5 STUB1 PSMA6 PPARGC1A PSMA3 PSMA4 PSMA1 PPARGC1B PSMA2 UBA52 PSMD12 PSMD11 PSMD14 WWP1 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC DLX5 PSMB1 DLX6 RPS27A HIVEP3 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TWIST1 CBFB CUL1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 95%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT GPAA1 PLAUR PIGK DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 METHYLATION%REACTOME%R-HSA-156581.6 Methylation AHCY TRMT112 TPMT MTR AS3MT MAT1A NNMT MTRR COMT CYP1A2 MAT2B HEMK2 MAT2A GSTO1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-212676.5 Dopamine Neurotransmitter Release Cycle APBA1 SNAP25 RAB3A STX1A SYT1 SYN3 SYN2 VAMP2 CPLX1 RIMS1 UNC13B PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SYN1 CASK LIN7A LIN7C LIN7B TSPOAP1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) NR5A1 YAP1 PCNA COX5B COX5A RELA ZFP14 PERP ZNF585B RXRG ZNF585A NPM1 GAD1 GAD2 COX6C ITCH GPAM TTC5 CCNG2 CCNG1 MAMLD1 ZFP28 PRDM7 IHH PRDM1 COX6A1 NR3C1 COX6A2 NPPA ARID2 G6PD MSX2 ZNF99 COX6B2 GEM COX6B1 ZNF92 GPRIN1 NDRG1 HIGD1C IRAK1 ZFHX3 AUTS2 VDR CNOT10 IL2 IL3 IL6 BMP2 CNOT11 TAF4B TCF3 YWHAE PRR5 DYRK2 LDB1 DPY30 CHD4 TRIAP1 PIDD1 YWHAQ MYBL2 YWHAG ZNF385A YWHAH TGIF1 ZNF75CP RBM14 TBP TGIF2 EED ELF1 ELF2 CAT TMEM219 TAF9 TAF1L RETN AURKA MTA2 RRM2 TAF15 TAF12 TAF13 ZNF804B TAF11 SOD2 REST CARM1 TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 ZNF175 MAML2 MAML1 ZSCAN32 NAMPT PIP4K2A PIP4K2B PIP4K2C JUNB ZNF169 RNF111 MED1 ZNF705G ZNF705D PRKCB ZNF160 MED8 ZNF705A MED4 MED6 MED7 PRKCQ MAML3 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 MAPKAP1 NEDD4L PRDX2 PRDX1 CGA NKX2-5 NR2C2AP NFE2 PLK3 PRELID1 ZNF383 ZNF141 ZNF140 ZNF382 PLK2 SETD1B SETD1A NFATC2 CDC7 NR1D2 NR1D1 ZNF37A ZNF702P BCL2L11 ZNF138 CDK12 CDK13 ZNF136 ZNF135 ZNF133 RET BTG2 RARG BTG1 PHF20 SETD9 CHM ASH2L POLRMT GLI3 GLI2 TAF7L TFAP2A ING5 TFAP2B ING2 PIP4P1 WWOX TFAP2C AIFM2 UBE2I TNKS1BP1 TFAP2D RSPO3 SUMO1 TEAD1 TFAP2E ZNF124 TEAD2 KCTD1 KCTD15 ZIK1 TEAD3 UBE2D3 TEAD4 BRD2 BRD1 ELOB TCF12 ELOC PAX5 RBX1 RARB AJUBA ZNF599 ZNF114 ZNF597 ZNF596 ZNF112 ZNF595 ZNF350 ZNF589 ZNF347 RNMT BRD7 CCNH ZNF587 ZNF586 POLR2A ZIM2 POLR2B ZNF343 POLR2C ZNF101 POLR2D ZIM3 POLR2E ZNF584 POLR2F ZNF100 POLR2G ZNF583 POLR2H CDKN2B POLR2I ZNF582 POLR2J PCGF6 POLR2K TIGAR POLR2L PCGF5 RNGTT WWP1 GTF2H1 GTF2H2 HIPK1 GTF2H3 POU4F1 SUPT5H POU4F2 HIPK2 GTF2F1 GTF2H4 ZNF33B ZNF33A GTF2F2 GTF2H5 RYBP ZNF337 CDK7 ERCC3 ZNF577 ERCC2 ZNF334 MNAT1 ZNF333 PF4 ACTB ZNF573 ZNF331 ZNF571 CSF2 ZNF570 YEATS4 ZFP30 ZNF569 ANG AFF4 ZNF568 MLLT1 ZNF567 MLLT3 ZNF566 SUPT6H ZNF324 ZNF565 IWS1 EAF1 ZFP37 EAF2 ZNF564 CSNK2A1 MEN1 ZNF563 IGFBP1 CSNK2A2 ZNF562 ZNF320 ZNF561 ZNF560 CSNK2B IGFBP3 NRBP1 KAT6A ZNF559 TP53 ZNF317 ZNF558 ZNF557 ZNF799 PGR ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 FKBP5 ZNF793 ZNF551 CSF1R ZNF792 ZNF550 ZNF791 ZNF790 ZNF767P ZNF549 ZNF548 ABL1 ZNF547 ZNF546 ZNF304 ZNF544 ZNF786 ZNF302 ZNF785 ZNF543 SKIL ZNF300 PLXNA4 MAP2K6 FANCI ESRRA ZNF782 ZNF540 ZNF658B ESRRB ESRRG FANCC CNOT4 CDK8 ZFP69 CNOT6 CNOT7 BCL6 CDK5 CNOT1 CNOT2 CNOT3 ZNF778 ZNF777 ZNF776 CNOT8 ZNF775 CNOT9 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 SIN3B ZNF529 ZNF528 WDR5 PSIP1 ZNF764 ZNF521 ZNF761 GPX2 CR1 ZNF75D ZFP90 ZNF75A ZNF519 ZNF517 CRH ZNF514 ZNF510 ZNF750 HDAC5 SMARCD1 SMARCD2 SMARCD3 RNF34 NLRC4 HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 RBBP7 ZNF500 RFFL ZNF740 SMARCE1 TXNRD1 PPP2R1B KCNIP3 PPP2R1A KLF4 PML ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 TP53RK HDAC10 HDAC11 SOX2 TP53AIP1 ZNF607 ZNF606 CHEK2 ZNF605 SOX9 ZNF600 RUNX3 COX7A2L ZNF839 ZFPM1 TWIST2 TWIST1 TXN NUAK1 TP53BP2 BANP GADD45A ZNF726P1 TPX2 OCLN CITED1 CITED2 CITED4 VENTX PRMT6 PRMT5 KRABD5 PPP2R5C PARP1 KRABD4 PRMT1 KRABD3 GP1BA SGK1 ZNF2 ZNF3 NPY ARNT2 BIRC5 NFYA NFYB NFYC MLH1 TJP1 FAS ZNF354A BMAL1 SRF ZNF354C CDK5R1 ZNF354B AURKB LMO1 LMO2 ATP1B4 LIFR PPP2CA KCTD6 PPP2CB FANCD2 COXFA4 NOP2 COX7A2 COX7A1 PMAIP1 CBX6 CBX3 SMURF1 SMAD6 ESR2 NR4A2 NR4A1 TP53I3 NR4A3 JMY KDM5B THRB THRA CGB8 SLC2A3 NR2E1 CASP6 CASP1 CASP2 OPRM1 GTF3C1 ARID1A GTF3C2 ARID1B GTF3C3 RBL2 GTF3C4 RBL1 CRCP IFNG GTF3C5 ZNF197 GTF3C6 ZNF195 BRF1 NR2C2 POLR3GL NR2C1 POLR3A THBS1 POLR3B HSPD1 VEGFA POLR3C ERBB2 POLR3D HES1 GLS2 POLR3E ZNF189 POLR3F ZNF286A POLR3G ZNF184 POLR3H ZNF180 BDP1 OPRK1 GLS POLR3K ARID3A POMC BAX CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 BCDIN3D CDK9 TCEA1 XPO5 DROSHA JAG1 MTERF1 HNF4A DLL1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ANGPTL4 LPL TSNAX PRKRA DICER1 TARBP2 TSN SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A TRPC3 MTA1 MTA3 ELAC2 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GCK DDX39B PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAN LBR CAV1 TGFB1 STEAP3 ITGA2B TDG ITGA5 SERPINE1 LIPE DGAT2 FABP4 CHD3 BMI1 LPIN1 SUMO2 MGLL RING1 RRP8 HDAC4 SAP130 HDAC2 DPF1 L3MBTL2 PDK4 DPF2 SATB2 KAT8 RNF2 DPF3 SAP30BP HCFC2 SUZ12 WDR82 CBX8 PAXIP1 PHC2 PEX11A PHC1 BAZ2A CBX5 KAT14 CBX4 PCGF2 SETDB1 SS18L1 CBX2 SMARCA5 PHC3 ZZZ3 GSK3B TADA2A ZNF816 EZH1 AXIN1 PHF1 SUV39H1 GPI SGF29 CD36 CDC73 JARID2 NCOA2 SS18 NCOA6 NCOA3 TET2 SKIC8 TET1 PPHLN1 BAZ1B PHF20L1 CTR9 RTF1 NR5A2 AEBP2 MTF2 TET3 LEO1 PLIN4 PAF1 PLIN2 MBD2 MYBBP1A MPHOSPH8 PNPLA2 ARID4B TTF1 PHLDA1 ADIPOQ SAP30 SPOCD1 ZNF93 ZCCHC8 DNMT1 CREBBP BOD1L1 SP1 TASOR MBIP TASP1 DR1 BOD1 EZHIP YEATS2 ZNF534 PHF19 PIWIL4 AKAP8L PAGR1 DNMT3L BCL7A BCL7C BCL7B CAMK4 DNMT3B UBTF BDNF ZNF765 KDM6A TGFA DNMT3A FOS POLR1A FOXO3 POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H AKT3 C19orf84 JUN ACSS3 UHRF1 CXXC1 DDX21 AGPAT2 TAF1D TAF1B TAF1C SAP30L TAF1A ATF7IP EPOP KANSL1 KANSL2 KANSL3 THRSP ERCC6 RRN3 CIDEC HCFC1 AR GATA3 ACTL6A DDB2 KAT2B KAT2A TAF9B USP9X MCRS1 YY1 USP7 NFIX SSB USP2 NFIA NFIB NFIC FOXO4 ATXN3 SUDS3 SMAD2 SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 TADA3 MDM2 MDM4 OGT PTEN TAF10 AKT2 GAMT PDPK1 EIF4A3 TFAM TFB2M CLP1 MAGOH SNRPD3 CDC40 INS DDX39A ZC3H11A SARNP SLBP PLD6 MAPK1 CAVIN1 CSTF3 CSTF2 DDX4 MAPK3 PTPN1 PTPN11 CSTF1 DHX38 SYMPK UPF3B MAGOHB SNW1 CAMK2B GRIA2 CAMK2D SRC RNPS1 CAMK2A GRIN2B PCF11 GRIN2A WDR33 CALM1 CAMK2G ANAPC15 ANAPC16 ANAPC7 SLU7 UBE2C FYTTD1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 SRRT CCNB1 CDC23 UBE2S SF3B1 CDC26 SRSF11 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUDT21 BLM MRE11 BRCA1 WRN CASC3 BRIP1 KAT5 EXO1 IPO8 CHEK1 RBBP8 NBN TOPBP1 ATRIP PAPOLA LSM10 BARD1 LSM11 MTREX RFC5 RMI2 INTS1 INTS3 RFC3 INTS2 RFC4 RMI1 INTS5 INTS4 THOC1 RFC2 INTS7 INTS6 THOC3 TOP3A INTS9 INTS8 RPA1 THOC2 INTS11 HUS1 THOC5 INTS12 RPA2 INTS13 THOC7 INTS14 THOC6 INTS10 SEM1 ICE1 RAD50 ICE2 RAD51D SSU72 RAD51 NABP2 SNRPG SRSF2 RPA3 NABP1 PHAX RAD17 RAD1 ELL2 SRSF3 ELL3 ATM SNRPE ZC3H8 DNA2 SRSF4 RAD9B RPRD2 RHNO1 RPAP2 ATR RPRD1B RAD9A RPRD1A SNRPF POU2F2 SRSF5 SRSF6 SRSF7 PIWIL2 TDRKH SNRPB SRSF9 PIWIL1 HENMT1 RBM8A ASZ1 MAEL MOV10L1 MYBL1 CPSF4 TDRD9 CHTOP TDRD6 TDRD1 TDRD12 CPSF1 FKBP6 ALYREF CPSF3 CPSF2 YBX1 RBM7 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SAP18 MORC2 GTF2A1 GTF2A2 GTF2B ACSL1 ELOVL5 GTF2E1 GTF2E2 KIT SCD TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CCND1 SIN3A CDK2 CTNNB1 MET CEBPB MDC1 ATF2 MT-CO1 EHMT2 DDIT3 EHMT1 RBPJ NOC2L ZNF17 ZNF287 TNRC6C ZNF18 MOV10 ZNF19 MEF2C AGO3 ZNF285 AGO4 RBFOX1 RBFOX3 MYC ZNF282 AGO1 ZNF10 AGO2 ZNF12 TNRC6A ZNF14 TNRC6B CLDN5 YWHAB SCO2 ZNF705EP PSMD8 DDIT4 PSMD6 TXNIP MT-CO2 PSMD7 MT-CO3 MYL9 XPO1 PSMD2 ZNF28 ZNF274 PSMD3 ZNF273 AKT1 MEAF6 PSMD1 ZNF20 GATA4 ZNF23 GATA1 ZNF25 ZNF26 SFN YWHAZ ZNF268 PSMA5 PPARGC1A PSMA6 ZNF267 PSMA3 PRELID3A PSMA4 PPARGC1B PSMA1 ZNF266 ZNF264 PSMA2 ZNF263 ABCA6 NR2F1 UBA52 ZNF34 NR0B2 PSMD12 NR2F6 PSMD11 COL1A1 COL1A2 PSMD14 ZNF30 ZNF257 PSMD13 ZNF256 EZH2 PSMA7 ZNF254 ZNF496 PSMB6 ZNF253 ZNF493 PSMB7 ZNF250 ZNF492 PSMB4 UCMA ZNF490 PSMB5 ZNF43 ZNF45 UBB MED16 PSMB2 MED15 PSMB3 MED17 BBC3 UBC MED12 PSMB1 MED14 MED13 RPS27A HEY1 CASP10 MED10 ZNF41 HEY2 CTLA4 ADRM1 ZNF248 MAPK14 ZNF486 MAPK11 ZNF485 PSMC5 ZNF484 PSMC6 ZNF483 PSMC3 CNOT6L PSMC4 ACTL6B PSMC1 ZNF480 PSMC2 MED27 SIRT1 MED26 SIRT3 MED23 MED25 MMP13 MED24 MED20 PPARG APAF1 ZNF479 PPARA ZNF235 ZNF234 CYCS ZNF233 PPARD ZNF473 ZNF230 ZNF471 SERPINB13 FURIN ZNF470 HTT BGLAP PLAGL1 SPP1 PMS2 ZNF227 RICTOR ZNF468 CPSF7 ZNF226 BID ZNF225 ZNF224 ZNF223 ZNF222 MBD3 SRRM1 ZNF221 ZNF461 ZNF460 STAT1 ATAD2 ZNF77 ZNF79 GATAD2B GATAD2A SKI ZNF70 ZNF71 ZNF74 AGRP ZNF699 ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZNF454 ZNF211 ZNF692 ZNF691 CCNT2 RORC RORA RORB SESN3 ZNF208 SESN2 ZNF205 ZNF689 ZNF688 ZNF446 KMT5A ZNF445 PITX2 ZNF202 ZNF443 ZNF200 ZNF684 ZNF442 ZNF441 BNIP3L ZNF682 HSP90AA1 ZNF440 ZNF681 EGFR ZNF680 ZFP69B CDC25C FOXP3 NPAS4 RB1 MAF CDKN1B MSH2 CCND3 ZNF439 FZR1 ZNF679 CCND2 ZNF678 E2F1 ZNF436 MAPKAPK5 ZNF677 SKP2 DAXX ZNF676 ZNF433 ZNF675 CDK6 ZNF432 TFDP1 PVALB CCNE2 ZNF431 TFDP2 ZNF430 CDK4 BLK CCNE1 KMT2D H2AX ZNF671 SPI1 ZNF670 CPAP MAX H2AB1 DLX5 H2AC19 DLX6 H2BC26 KMT2C H2AC14 KMT2B H2BC12L FOXO6 H2BC21 FOXO1 MYB ZNF840P EP300 SOCS3 MOBP H3-3B ZKSCAN7 H3C8 MED30 H2AC8 ZNF429 H2AC6 MED31 H2AC7 ZKSCAN8 H2BC17 ZKSCAN3 RUNX1 SMYD2 H2BC12 ZNF669 H2BC13 ZNF668 H2BC14 ZNF426 H2AJ ZNF667 H2BC15 ZKSCAN5 TAL1 ZNF425 H2BC11 ZKSCAN4 RARA ZNF665 CEBPA KMT2A ZNF664 ZKSCAN1 CBFB SOCS4 GATA2 BCL2L14 H3C15 ZNF662 ZNF420 RXRA ZNF660 H2BC9 BRPF1 H2AZ2 BRPF3 H4C9 TNFRSF10C H2BC8 TNFRSF10B H2BC5 TNFRSF10A H2BC3 FBXO32 G6PC1 H2BC1 NFKB1 DEK TNFRSF10D RGCC ZNF419 H2AC20 ZNF418 ZNF417 ZNF658 HDAC3 ZNF416 ZNF415 PIN1 GPS2 ZNF655 RXRB SP7 PPP1R13B COX4I1 COX4I2 APOE FASLG TBL1X ITGAL PCK1 PPP1R13L NCOA1 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 NR1H2 ITGA4 TNFRSF18 ARNT NCOR2 RABGGTB RABGGTA RRM2B NCOR1 HAND2 TBL1XR1 ZNF875 PPM1D ZNF627 ZNF626 TP53INP1 PLIN1 ZNF625 ZNF624 E2F4 ZNF621 E2F5 ZNF620 E2F6 E2F7 E2F8 ZNF860 MGA TBX5 PINK1 ZNF619 SST IL2RA ZNF616 SYT10 ZNF615 ZNF614 ZNF613 STUB1 ZNF611 PTPN4 ZNF610 TRIM33 CCNK SMARCB1 CCNC UXT LGALS3 ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 CCN2 ZNF721 TP63 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 L3MBTL1 ZNF324B FOXG1 ZNF709 ZNF708 ZNF707 ZNF706 PCBP4 ZNF704 ZNF703 ZNF701 HIVEP3 ZNF700 WWTR1 YES1 CRADD IQSEC3 SMARCA2 SMARCA4 ITGBL1 TP73 COX7B MSTN HNF4G CTSV COX7C CTSL CTSK COX8A SREBF1 COX8C PBRM1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 PCBP4 TP53 CDKN1A ZNF385A MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation MT-ND6 COX5B MRPS10 COX5A MT-ND5 MT-ND2 MRPL32 MT-ND1 ECI1 PCCB SUCLG2 UQCRC2 PRKACA MRPS2 OGDH MT-ATP6 STAR FH SHMT2 TRIAP1 ATP5PF ATP5PD MRPL12 MDH2 ATP5F1C ATP5PO NDUFA13 SLC25A5 SLC25A6 HSD17B10 SPG7 AFG3L2 SMDT1 YME1L1 PMPCA NDUFV3 ATP5MG MICU2 NDUFV1 STARD7 IDH2 UQCRQ TFAM HADH OMA1 OPA1 ALDH1B1 ME2 IDH3A BDH1 OXCT1 HMGCS2 PRELID1 ACAT1 NDUFS1 CHCHD2 NDUFB6 COX4I1 IARS2 ARG2 MT-CO1 HTRA2 ECH1 ACOT2 NDUFA2 LONP1 TWNK SSBP1 LDHD MT-CO2 NDUFS3 CS HSPD1 ACO2 PDHB GLUD1 TIMM17A PDK1 PDHA1 TIMM22 HSPA9 OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 ALAS1 TIMM9 TIMM10 ATP5F1A ALDH2 ATP5F1B DBT DLD PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.2 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy SQSTM1 UBC MAP1LC3B PEX5 NBR1 RPS27A ATM EPAS1 UBA52 USP30 UBB RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 95%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB RIPK1 MYD88 ZBP1 TICAM1 RELA TLR3 NFKB1 NFKBIA DHX9 NFKB2 CHUK RIPK3 NFKBIB NKIRAS1 NKIRAS2 IKBKG NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 95%3301854 Nuclear Pore Complex (NPC) Disassembly NUP85 TPR NUP62 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 CDK1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC CCT6A TUBA1C CCT2 TUBA1A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 ACTB PFDN4 PFDN5 CCT6B PFDN6 TUBB6 TUBB3 CCT7 TUBB1 TUBA3D TUBA3C CCT8 CCT5 CCT4 TUBA4A TUBB4B TUBB4A REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components ACTN1 PXN TESK1 PARVA PARVB ARHGEF6 RSU1 LIMS1 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.4 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 HBEGF EGF ERBB2 EGFR NRAS NRG1 HRAS EREG NRG3 NRG4 NRG2 BTC GSD XV%REACTOME%R-HSA-3814836.4 GSD XV GYG1 GYS1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.3 N-glycan antennae elongation in the medial trans-Golgi CHST8 B4GALT4 CGA FUT8 MAN2A1 MGAT5 MGAT2 FUCA1 MGAT3 MGAT4C CHST10 B4GALT6 B4GALT5 MAN2A2 ST3GAL4 MGAT4A LHB MGAT4B B4GALT1 ST8SIA6 FUT3 ST8SIA2 B4GALT2 B4GALT3 ST8SIA3 ST6GAL1 PI METABOLISM%REACTOME DATABASE ID RELEASE 95%1483255 PI Metabolism MTMR3 MTMR8 MTMR9 PIK3R4 RAB14 PIK3R2 MTMR6 PIK3R1 MTMR7 PITPNB INPP5E PIP5K1A PIP5K1B GDE1 SACM1L ARF3 MTMR14 VAC14 PI4KA PI4K2B MTMR10 MTMR2 MTMR12 PI4KB TNFAIP8 PIK3C2A MTMR4 MTM1 INPP4A FIG4 PIP4P1 INPP4B INPP5J INPP5K PIKFYVE INPP5F PI4K2A PTEN MTMR1 PIP5K1C TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 GDPD1 RAB4A GDPD3 GDPD5 RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PNPLA7 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 PNPLA6 INPPL1 RUFY1 TPTE ENPP6 SBF1 PIK3CA PIK3R3 SBF2 TPTE2 PIK3C3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 95%5467333 APC truncation mutants are not K63 polyubiquitinated APC MALATE-ASPARTATE SHUTTLE%REACTOME%R-HSA-9856872.2 Malate-aspartate shuttle SLC25A11 MDH1 GOT1 MDH2 SLC25A12 SLC25A18 GOT2 SLC25A13 SLC25A22 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX9 MYD88 NFKB2 RELA NFKB1 IRF7 DHX36 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME%R-HSA-9726840.2 SHOC2 M1731 mutant abolishes MRAS complex function MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB PROTEIN METHYLATION%REACTOME%R-HSA-8876725.5 Protein methylation RPS2 METTL21A KIN METTL22 HSPA8 EEF2KMT VCPKMT ETFBKMT EEF1AKMT2 EEF1AKMT1 EEF2 EEF1A1 CAMKMT VCP PRMT3 CALM1 ETFB TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159230 Transport of the SLBP Dependant Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 SLBP NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 95%73893 DNA Damage Bypass PCNA UBA52 NPLOC4 POLH WDR48 USP10 RAD18 PCLAF VCP USP43 REV1 ISG15 MAD2L2 SPRTN REV3L POLI UFD1 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 USP1 DTL UBA7 RPA1 RPA2 DDB1 POLE4 CUL4A RPA3 RBX1 UBE2L6 TRIM25 UBE2B POLE2 POLE3 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.4 Cardiac conduction KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 PRKACA ATP2A1 SLC8A1 SLC8A2 NOS1 NPPA STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI KCNK12 KCNK15 FXYD4 FXYD3 FXYD2 DMPK FXYD1 FXYD7 FXYD6 MME ATP2B4 NPR1 RYR1 ATP2B3 NPR2 RYR2 ATP2B2 NPPC RYR3 ATP2B1 TRPC1 CORIN CES1 SLC8A3 CLIC2 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 FGF14 FGF13 TRDN FGF12 FGF11 ASPH KCNK5 ATP1A4 CACNG6 ATP1A3 CACNG7 ATP1A2 TNNI3 ATP1A1 KCNIP1 KCNIP2 KCNIP4 KCNK6 RANGRF KCNK7 PLN KCNK1 KCNIP3 FKBP1B CACNA2D2 CACNB2 NKX2-5 SCN11A SCN10A CACNB1 SCN1B CAMK2B SCN1A CAMK2D CAMK2A KCNH2 TBX5 SCN3B SCN3A KCNK10 CACNG8 GATA4 CALM1 KCNK13 SCN2A CAMK2G KCNK16 SCN2B KCNK17 KCNK18 KCNQ1 CACNG4 KCNJ2 KCNJ4 SCN9A KCNK9 SCN8A KCNJ12 CACNA1C HIPK1 KCND1 KCND2 KCND3 HIPK2 SCN5A SCN4A KCNA5 SCN4B SCN7A AKAP9 KCNJ14 KAT2B KCNK2 KCNK3 KCNK4 WWTR1 AHCYL1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors GPR31 FFAR4 FFAR1 FFAR3 FFAR2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PI4K2B PI4KB PIK3C2A PIK3R4 PIK3C2G FIG4 PIKFYVE PI4K2A ARF1 INPP5E TPTE SACM1L ARF3 OCRL TPTE2 PIK3C3 VAC14 PI4KA INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME DATABASE ID RELEASE 95%445095 Interaction between L1 and Ankyrins KCNQ2 KCNQ3 SCN9A SCN11A SCN10A SCN8A SPTAN1 SPTA1 SCN5A SCN4A SCN4B SCN7A NRCAM SPTB ANK1 SCN1B SCN1A NFASC ANK2 ANK3 SPTBN4 SPTBN5 SCN3B SCN3A SPTBN2 SPTBN1 L1CAM SCN2A SCN2B CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 95%9634285 Constitutive Signaling by Overexpressed ERBB2 ERBIN HRAS SOS1 HSP90AA1 SHC1 ERBB2 CDC37 NRAS PTPN12 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSENEN NCSTN APH1B PSEN2 PSEN1 YBX1 NOTCH3 APH1A ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 PRKAA2 CAB39 CAB39L PRKAG1 PRKAG2 PRKAG3 RPTOR STK11 MLST8 SLC38A9 PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage MAPDA GMPR2 ADK AMPD1 TK1 GMPR AMPD2 CDA AMPD3 DCK APRT DGUOK PNP HPRT1 ADA UCKL1 UCK2 UCK1 PUDP TK2 UPP2 UPP1 TYMP TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules SLC26A2 SLC22A5 ABCB6 SLC24A2 ABCB4 SLC24A3 KCNJ11 SLC41A2 SEL1L SLC5A1 SLC41A1 SLC5A2 SLC30A10 ABCC9 ADCY9 SLC39A6 SLCO1B1 SLC39A5 SLCO1B3 ERLIN1 ADCY4 SLC39A8 ERLIN2 ADCY3 SLC39A7 CP ADCY2 SLC39A2 SLC6A5 ADCY1 SLC39A1 ADCY8 SLC39A3 SLC2A9 ADCY7 SLC26A4 SLC30A8 ADCY6 RNF185 SLC30A3 ADCY5 SLC26A3 SLC30A2 SLC31A1 SLC30A5 SLC40A1 SLC39A10 SLC2A1 ATP2A3 SLC30A1 SLC2A2 ATP2A2 SLC6A2 SLC39A14 ATP2A1 SLC6A3 SLC8B1 SLC8A1 SLC8A2 SLC22A12 HEPH ABCC2 SLC2A10 ABCC6 AVPR2 SLC24A4 SLC16A7 DERL3 SLC16A8 DERL1 EMB DERL2 SLC16A3 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 RHAG SLC24A5 APOB ATP2B4 ATP2B3 ATP2B2 ATP2B1 SLC8A3 GNAS RAB11A SLC6A20 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC3A1 SLC1A3 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC1A6 SLC1A7 SLC7A1 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 NEDD4L ADD1 TUSC3 MAGT1 ZDHHC8 SLC46A1 SLC5A5 VDAC3 VDAC2 VDAC1 CFTR SLC32A1 SLC6A13 SLC6A1 ARF1 WWP1 CYB5R2 CYB5R4 CYB5RL SLCO1A2 NEDD8 ARL2 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 FBXL5 GNGT1 GNGT2 VCP GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 SLCO4C1 HMOX2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 LETM1 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 TCIRG1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC6A7 ATP6V0B PLEKHA8 ATP6V0E1 ATP6V1G2 ATP6AP1 SLC6A11 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ABCG2 ATP6V0A2 SGK1 HBB ATP6V1H SLC6A4 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 SLC17A7 ABCA3 ABCC3 CAMK2B ABCC1 CAMK2D ABCD3 CAMK2A SLC2A3 CALM1 CAMK2G ADD3 SLC4A7 PHB1 SLC25A10 CAND1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SEM1 SLC4A2 SLC4A3 SLC4A5 SLC5A8 SKP1 SLC5A9 TFR2 SLC60A2 SLC5A4 SLC2A14 SLC2A11 SLC2A12 NIPA1 CUL1 NIPA2 CLTC SLCO4A1 SLC17A1 HDLBP RHBG PCSK9 CLTA DMTN SLCO2B1 AP2A1 SLC26A11 VLDLR LIPA SLC16A2 RHCG AP2A2 LIPC SLC26A1 CREB3L3 SLC15A1 IREB2 LIPG SLC14A1 CTNS LDLRAP1 SLC15A3 SLC14A2 AP2M1 SLC15A4 SLC4A10 CUBN CYBRD1 CYB5R1 PIP AMN SLC26A7 APOA2 ACO1 APOA1 SLC26A9 LSR SLC26A6 APOA4 PRKACG SLC25A1 APOA5 MB NPC1 RAF1 PRKACA SLC13A1 SOAT1 PRKACB SLC13A2 SOAT2 SLC13A3 NPC2 ANGPTL8 ATP7A SLC13A4 ANGPTL4 NGB SLCO1C1 LPA SLC47A2 CES3 TF CA1 SAR1B SLC47A1 SLC5A12 MTTP SLC5A10 LPL CA2 LMF2 SLC25A26 LMF1 LRRC8C CA4 LRRC8D APOF AP2S1 LRRC8A LRRC8B A2M LDLR SLC13A5 SLC11A1 GPIHBP1 LRRC8E GLTP FGF21 RSC1A1 MBTPS1 APOBR AHCYL2 APOC3 NIPAL4 NIPAL1 AP2B1 NIPAL2 TRPM1 NCEH1 ALB NIPAL3 TRPM2 P4HB AZGP1 TRPM7 SLC22A4 TRPM8 MBTPS2 SLC22A3 TRPM5 SLC22A6 TRPM6 SLC45A3 TRPM3 ANKH TRPM4 TRPC7 RAB11FIP2 ABCC4 TRPC5 SLC10A6 MCOLN3 MYO5B TRPC6 MRS2 AQP12A TRPA1 SLC22A15 AQP10 TRPC3 AQP8 SLC22A16 TRPC4 AQP9 SLC22A17 TRPC1 AQP6 SLC22A11 AQP7 SLC20A1 TRPV2 AQP4 SLC66A1 TRPV3 AQP5 FTMT TRPV1 MCOLN1 AQP2 ESYT3 MCOLN2 AQP3 ESYT2 AQP1 STEAP4 TRPC4AP MIP HFE TRPV6 MMGT1 TRPV4 AQP11 TRPV5 SLC2A6 SLC2A7 SLC2A8 PDZD11 GLRX3 CPTP ADD2 CLN3 SLC50A1 SLC4A8 SLC4A9 SLC35B3 LCN9 SLC35B2 STOML2 SLC27A1 MCUB LCN2 SLC35B4 SPG7 PHB2 SLC35D1 MAIP1 SLC35D2 LCN15 PARL AFG3L2 LCN12 SMDT1 SLC35A2 YME1L1 SLC35A3 PMPCB SLC33A1 SLC5A6 PMPCA ARL2BP MICU3 LCN1 MICU2 SLC29A4 MICU1 PRKAR1B SLC27A6 MCU PRKAR2B SLC28A2 PRKAR1A SLC29A1 PRKAR2A SLC2A13 SLC28A1 SLC29A3 SLC5A11 SLC5A3 SLC29A2 SLC28A3 SLC27A4 CYGB EIF2S2 EIF2S1 EIF2S3 PSMD8 PSMD6 HMOX1 PSMD7 PSMD2 PSMD3 PSMD1 TFRC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 SLC20A2 ABCA6 ABCD2 UBA52 AKAP1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 SLC6A9 PSMB7 SLC17A6 PSMB4 PSMB5 UBB PSMB2 ABCC10 PSMB3 ABCC11 UBC ABCC5 PEX3 ABCA10 PSMB1 ABCG4 ABCB1 RPS27A ABCB7 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ADRM1 SLC1A5 ABCA5 ABCA4 ABCA9 PSMC5 ABCA7 PSMC6 ABCA8 PSMC3 ABCB10 PSMC4 PSMC1 PSMC2 PEX19 ATP8A2 ATP8A1 ATP12A BEST2 SLC9C1 FURIN BEST3 PCSK6 SLC9C2 BEST1 PCSK5 BEST4 ESYT1 SLN ATP11C SLC67A1 ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 SLC9B1 SLC9B2 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 ATP8B4 ATP8B3 ATP8B2 STEAP3 ATP8B1 ATP4B ATP4A FXYD4 FXYD3 WNK1 FXYD2 WNK2 FXYD1 HBA2 WNK3 FXYD7 FXYD6 CUTC RYR1 RYR2 RYR3 UNC80 ATP7B CLIC2 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 CLCN3 ATP2C1 CLCN2 CLCN1 PLN BSND ANO10 ATP9B SLC17A3 ATP9A ATP13A1 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 SLC22A7 STOM SLC12A2 SLC12A4 RUNX1 SLC12A5 SLC12A7 FTH1 FTL SLC25A18 CETP SLC25A11 APOD APOE ABCA1 ABCG8 MYLIP SLC25A22 ABCG5 NR1H2 APOC4 NR1H3 APOC2 APOC1 ANGPTL3 ABCG1 SLC35C1 SLC24A1 SLC17A5 AVP SLC2A4 SLC35A1 SLC22A8 SLC4A1 ABCA12 SLC4A4 BSG SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 95%5621575 CD209 (DC-SIGN) signaling CREBBP RELA ICAM2 LYN ICAM3 RELB NFKB1 EP300 NRAS PAK1 PAK3 HRAS FYN PRKACG RAF1 PRKACA PRKACB PAK2 CD209 RPS6KA5 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 95%9709603 Impaired BRCA2 binding to PALB2 BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B RAD50 RAD51D BLM RAD51 MRE11 RAD51C BRCA1 BRCA2 RAD51AP1 WRN ATM BRIP1 DNA2 KAT5 EXO1 RBBP8 NBN MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 95%9865114 Maple Syrup Urine Disease PPM1K BCKDHA BCKDHB DBT DLD VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 95%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 95%1538133 G0 and Early G1 PCNA CDC6 HDAC1 DYRK1A CDK1 CDC25A E2F1 RBBP4 CDK2 TFDP1 CCNE2 TFDP2 LIN54 TOP2A LIN37 CCNE1 LIN9 MAX LIN52 MYC E2F4 E2F5 CCNA2 CCNA1 MYBL2 RBL2 RBL1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO6 FOXO3 FOXO1 RPS6KB2 AKT1 AKT2 FOXO4 NR4A1 AKT3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis RXRA SCD NR1H2 FASN NR1H3 RXRB NRIP1 ANGPTL3 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 HSP90B1 DDIT3 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 CDC25A PKMYT1 WEE1 CLSPN YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 CDC25C ABRAXAS1 TP53BP1 H2AX H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 CHEK2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDC7 CDK2 CDC45 MDC1 MCM10 DBF4 YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 SFN YWHAZ PSMA5 PIAS4 PSMA6 PSMA3 PSMA4 BRCC3 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 BLM MRE11 PSMA7 BRCA1 BABAM1 PSMB6 BABAM2 PSMB7 WRN BRIP1 KAT5 PSMB4 EXO1 UIMC1 CHEK1 PSMB5 RBBP8 NBN UBB TOPBP1 PSMB2 ATRIP PSMB3 BARD1 UBC RFC5 RMI2 PSMB1 RFC3 GTSE1 RFC4 RPS27A RMI1 RFC2 TOP3A ADRM1 RPA1 HUS1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 RAD50 PSMC4 PSMC1 MCM7 PSMC2 MCM8 RPA3 RAD17 TP53 CCNB2 CCNA2 RAD1 ATM CCNA1 DNA2 MCM3 RAD9B MCM4 RHNO1 MCM5 ATR MCM6 RAD9A MCM2 ORC5 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9768777 Regulation of NPAS4 gene transcription REST SRF NR3C1 KCNIP3 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%8851907 MET activates PI3K AKT signaling MET GAB1 PIK3R1 HGF PIK3CA G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint WEE1 CCNA2 CCNB2 CCNA1 CCNB1 CDK1 PKMYT1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade RPS6KA1 JUN RELA MAP3K7 MAP2K6 TIRAP IRAK1 NFKBIA TLR1 TAB1 S100A9 S100A8 TLR2 TRAF2 TRAF6 CD14 USP14 BTRC NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 SOCS1 ATF2 IKBKB PPP2CA MYD88 PPP2CB SIGIRR IRAK3 MEF2C TLR6 CD36 MAPKAPK2 UBA52 BTK NFKB2 FGB S100A1 ATF1 FGA ECSIT NKIRAS1 NKIRAS2 FGG MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169091 Activation of NF-kappaB in B cells RELA MAP3K7 NFKB1 CHUK IKBKB CARD11 MALT1 NFKBIA PSMD8 PSMD6 PSMD7 PSMD2 REL NFKBIE PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PSMC5 PSMC6 PRKCB SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 NFKBIB CUL1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.4 VxPx cargo-targeting to cilium EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 ASAP1 RAB11FIP3 RAB8A ARF4 GBF1 PKD2 RAB3IP PKD1 RAB11A RHO CNGA2 CNGA4 EXOC8 EXOC7 CNGB1 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 95%3359469 Defective MTR causes HMAG MTR MTRR INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.3 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane FRAT2 FZD2 APC FZD5 PPP2R5B WNT1 PPP2R5A FZD1 PPP2R5D PPP2R5C CSNK1G2 WNT3A LRP5 CTNNB1 LRP6 WNT8A WNT8B PPP2R1B PPP2R1A PPP2CA PPP2CB DVL1 DVL2 DVL3 AMER1 GSK3B CSNK1A1 CAV1 FRAT1 PPP2R5E AXIN1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis GNPAT DHRS7B AGPS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 95%913709 O-linked glycosylation of mucins MUC13 B3GNT3 B3GNT5 B4GALT6 B4GALT5 GALNT12 ST6GALNAC2 C1GALT1C1 MUC12 ST6GAL1 MUC15 MUCL1 MUC3A MUC5AC MUC3B GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ST6GALNAC3 GALNT10 GALNT9 ST6GALNAC4 MUC1 GALNT8 MUC2 B3GNT9 QTGAL B3GNT8 B3GNT6 MUC7 GALNT1 CHST4 MUC4 GCNT1 MUC6 GCNT3 MUC16 GCNT4 GALNT3 GCNT7 MUC17 GALNT7 C1GALT1 GALNT6 MUC19 GALNT5 ST3GAL4 GALNT4 MUC5B A4GNT MUC20 GALNTL5 MUC21 GALNT2 GALNTL6 ST3GAL1 ST3GAL2 ST3GAL3 B3GNT7 B3GNT4 B3GNT2 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%5674135 MAP2K and MAPK activation IQGAP1 NRAS FN1 MAPK1 RAP1B ARAF RAP1A PEBP1 CSK RAF1 MARK3 FGB FGA VWF MAPK3 KSR1 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL WDR83 SRC YWHAB HRAS IL17RD ARRB1 ARRB2 LAMTOR2 MAP2K1 MAP2K2 ITGB3 LAMTOR3 ITGA2B RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.2 Release of Hh-Np from the secreting cell DISP2 SCUBE2 SHH IHH DHH ADAM17 NOTUM GPC5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 95%8848021 Signaling by PTK6 GPNMB LRRK2 PTK6 HBEGF STAT3 NRAS RHOA CCND1 CDK2 ELMO2 NR3C1 PTPN1 ELMO1 NRG1 EPAS1 AKT1 HIF1A DOCK1 CRK PXN ERBB2 EGF CBL EGFR ARHGAP35 UBA52 CDKN1B CDK4 CCNE1 UBB ARAP1 UBC RPS27A PELP1 DOK1 SFPQ RASA1 SOCS3 KHDRBS1 KHDRBS2 KHDRBS3 STAP2 SRMS RAC1 HRAS BCAR1 EREG NRG3 NRG4 NRG2 BTC LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.5 Leading Strand Synthesis RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance KIFAP3 APOOL PRKACA KIF3B KIF3C ARF4 PKD2 PKD1 BBS9 CNGA2 BBS7 YWHAE CNGA4 BBS5 BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 BBS12 YWHAG RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 RAB11A ATAT1 TTC8 SOD2 CARM1 DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 MED1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 ACSS2 NR1D1 CHCHD3 PRKAA2 ATF2 PRKAG1 PRKAG2 PRKAG3 POLRMT POLG2 MEF2C PRKAB2 TWNK ATP5MC1 PRKAB1 SSBP1 CCP110 MAPK12 TNPO1 HCFC1 PPARGC1A PPARGC1B CEP57 CETN2 CEP164 ACTR1A PCM1 NRF1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HSPA9 HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 ALAS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 MAPK14 HAUS8 MAPK11 HAUS7 CEP70 CEP72 CEP192 PCNT TUBA4A CEP76 CEP78 PLK4 ATP5F1A SIRT3 ATP5F1B ODF2 CEP152 NEDD1 ALMS1 MTX2 PPARA CEP41 CYCS CEP43 IFT172 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 CCT3 RPGRIP1L DMAC2L WDR35 IFT88 SMO TCP1 ESRRA KIF3A TTC21B WDR19 IFT122 MKS1 MT-ATP6 CCT8 CCT5 CCT4 CEP97 TUBB4B KIF17 TUBB4A ATP5PF ATP5PD ATP5PB ATP5F1C HSP90AA1 ATP5F1D MT-ATP8 ATP5F1E SMARCD3 ATP5PO HDAC6 RHO CNGB1 PPP2R1A CPAP ATP5MC2 ATP5MC3 ATP5MK ATP5MJ ATP5MG ATP5MF ATP5ME IDH2 TFAM TFB2M RXRA DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 SAMM50 PDE6D HDAC3 MTX1 MAPRE1 PAFAH1B1 TBL1X DYNC1I2 NCOA1 NCOR1 CLASP1 TBL1XR1 DYNC1H1 NDE1 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 CALM1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 NCOA2 NCOA6 CDK1 GLUD1 GLUD2 SIRT4 CRTC2 CRTC3 CRTC1 HELZ2 CREBBP CHD9 MICOS13 MICOS10 CHCHD6 MTERF1 RAB8A GABPA SIRT5 TGS1 PPRC1 MEF2D PERM1 APOO CAMK4 DNAJC11 IMMT TMEM11 TFB1M RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing MRM3 RCC1L RPUSD4 NGRN DDX21 RPUSD3 NOP58 RPS4Y2 RPS27L RPS4Y1 TRMT10C PRORP RPS4X RPS15 ELAC2 RPS14 RPS17 HSD17B10 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 REPRODUCTION%REACTOME%R-HSA-1474165.7 Reproduction SOX17 POU5F1 FKBP6 SPAM1 LMNB1 CXCR4 PRDM1 PDPN FIGNL1 TEX12 TEX15 MSH4 MSH5 CD9 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B HVCN1 MND1 FIRRM REC8 SYCP3 STAG3 DMC1 PSMC3IP MLH3 CDK4 PRDM9 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L SPO11 H2BC21 SUN2 SUN1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 EOMES H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ STAG1 H2BC15 STAG2 H2BC11 RAD21 NANOS3 CBFA2T2 H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 BMP4 H2BC1 POT1 TERF2IP H2AC20 NANOG HSPA2 CDK2 MLH1 B4GALT1 TFAP2C UBE2I CATSPER1 CATSPER3 CATSPER2 CATSPER4 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ACR ADAM2 KCNU1 CATSPERB CATSPERD CATSPERG ZP1 ZP3 ZP2 TET2 ZP4 BLM MRE11 BRCA1 BRCA2 RBBP8 NBN TOP3A RPA1 RPA2 RAD50 RAD51 RAD51C RPA3 ATM ATR DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PAN3 PAIP1 LSM5 LSM4 SKIC2 LSM3 LSM2 LSM7 LSM6 DDX6 LSM1 PATL1 CNOT4 EDC3 EDC4 CNOT6 DCP1B CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT11 DIS3 XRN1 SKIC8 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 CNOT6L EIF4A2 EIF4A1 DCP1A TUT7 TUT4 EIF4G1 HBS1L NT5C3B SKIC3 EIF4A3 DCPS PAN2 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 95%5602498 MyD88 deficiency (TLR2 4) MYD88 CD36 LY96 TLR1 BTK CD14 S100A9 TLR6 S100A8 TLR2 FGB HMGB1 S100A1 FGA FGG TIRAP TLR4 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-HSA-209543.3 p75NTR recruits signalling complexes IKBKB SQSTM1 UBC MYD88 RPS27A IRAK1 NGF TRAF6 UBA52 NGFR PRKCI UBB RIPK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%2197563 NOTCH2 intracellular domain regulates transcription RBPJ MAML2 FCER2 MAML1 MAMLD1 HES1 MAML3 EP300 GZMB NOTCH2 HES5 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.3 MAPK targets Nuclear events mediated by MAP kinases RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 MAPKAPK2 MAPK1 MAPK8 ATF1 MAPK3 ATF2 PPP2R1B PPP2R1A PPP2CA PPP2CB MEF2C MAPK9 MAPK14 MAPK11 MAPK10 FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2BC9 H2AZ2 DDX21 H4C9 H2BC8 TAF1D H2BC5 TAF1B H2BC3 TAF1C H2BC1 TAF1A DEK HDAC1 H2AC20 ERCC6 MBD3 EHMT2 GATAD2B GATAD2A CHD3 CBX3 HDAC2 CHD4 SMARCA5 GSK3B TBP POLR2E POLR2F POLR2H SF3B1 BAZ1B POLR2K POLR2L MTA2 RBBP4 MTA1 MYBBP1A MTA3 TTF1 RBBP7 ACTB H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B H2BC11 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H H3C15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 95%9615933 Postmitotic nuclear pore complex (NPC) reformation NUP85 NUP62 NUP43 RCC1 RAN NDC1 SEC13 RANGAP1 UBE2I NUP155 NUP133 SUMO1 NUP93 NUP35 NUP54 NUP205 NUP37 POM121 NUP107 NUP188 KPNB1 TNPO1 NUP160 AHCTF1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174414 Processive synthesis on the C-strand of the telomere ACD LIG1 PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 BLM RPA3 WRN DNA2 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME DATABASE ID RELEASE 95%9841922 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.3 Synthesis of bile acids and bile salts via 24-hydroxycholesterol AMACR AKR1C1 SLC27A2 SLC27A5 AKR1C2 AKR1C4 CYP8B1 AKR1C3 AKR1D1 CYP46A1 CYP27A1 CYP39A1 HSD3B7 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 95%5675482 Regulation of necroptotic cell death XIAP STUB1 UBE2L3 TRAF2 TNFSF10 TNFRSF10B HSP90AA1 TNFRSF10A CDC37 FADD UBA52 BIRC2 BIRC3 ITCH RIPK3 FAS FASLG PELI1 UBB RIPK1 UBC RPS27A PRKN SDCBP MLKL OGT TRADD CASP8 FLOT1 FLOT2 PDCD6IP APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 95%179409 APC-Cdc20 mediated degradation of Nek2A ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 UBA52 CDC27 CDC16 ANAPC4 NEK2 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 UBB UBC BUB3 RPS27A MAD2L1 ANAPC15 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 95%8849468 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.4 Glutathione conjugation HPGDS GSTA3 GSTA1 GSTM4 AKR1A1 GSTT2 GSTT1 ESD GSTT2B GSTM3 GSTM2 GSTM1 GSTM5 GSTK1 GSTO2 GSTZ1 GSTA5 GSTA4 GSTO1 CHAC1 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GSTA2 GGT3P GGT1 GCLM MGST3 MGST1 GSTP1 MGST2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 95%8964038 LDL clearance CLTC PCSK9 AP2S1 CLTA AP2A1 LDLR LIPA AP2A2 AP2B1 NCEH1 LDLRAP1 AP2M1 LSR APOB NPC1 SOAT1 SOAT2 NPC2 CES3 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME DATABASE ID RELEASE 95%9035968 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 95%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes ITGA5 PIEZO1 CACNA2D1 SPP1 CACNG7 GJA1 CACNA1H PANX1 HSPG2 CACNB2 AKT1 ITGB3 P2RX7 ITGB1 CACNB1 CACNB3 ITGAV SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6PC3 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 95%9652817 Signaling by MAPK mutants MAPK1 DUSP9 DUSP6 DUSP16 DUSP7 DUSP10 DUSP8 UBIQUINOL BIOSYNTHESIS%REACTOME%R-HSA-2142789.6 Ubiquinol biosynthesis COQ9 COQ7 COQ6 COQ5 COQ2 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A STARD7 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.4 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2730905 Role of LAT2 NTAL LAB on calcium mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN LAT2 SYK FYN BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 95%9018679 Biosynthesis of EPA-derived SPMs HPGD PTGS2 ALOX15 ALOX5 LTA4H PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%73817 Purine ribonucleoside monophosphate biosynthesis ADSS2 GART PAICS PFAS IMPDH1 ADSL IMPDH2 PPAT ATIC GMPS ADSS1 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 95%449147 Signaling by Interleukins JUN RELA IRAK1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A IL1B PELI1 MMP1 MMP2 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 MAPK8 SOCS1 IKBKB SQSTM1 MYD88 FCER2 CANX PTGS2 ALOX5 RBX1 SDC1 HIF1A SNAP25 GATA3 LYN INPP5D ARF1 RALA RPLP0 IL1RN PITPNA BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CSF1R MAP3K7 FPR1 MAP2K6 TCP1 BCL6 SMAD3 NFKBIA TAB1 TRAF2 TEC TRAF6 USP14 NOD1 ITGAM ITGB2 NOD2 IRS1 USP18 PPP2R1B IRS2 PPP2R1A PIK3CB FGF2 TNFRSF1B SOX2 TNIP2 PTPN13 INPPL1 TWIST1 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 SHC1 PPP2R5D PIK3R2 PIK3R1 RHOU ALOX15 MAPK1 BIRC5 CHUK MAPK3 PTPN11 CDC42 LIFR PPP2CA PPP2CB HNRNPF CASP1 OPRM1 IFNG MCL1 CD86 PTK2B CD80 VEGFA IL22 POMC CXCL1 NFKB2 JAK2 HNRNPA2B1 IL2RG MMP9 FBXW11 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B CCL3L3 CCR5 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 P4HB PRTN3 TIMP1 POU2F1 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FN1 BRWD1 BLNK BTRC S1PR1 JAK3 CD4 LCN2 STAT2 MMP3 IL23R IL13RA2 IL13RA1 IL4R IL23A CDKN1A FSCN1 NDN LIF NANOG IGHE OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 IL11 PIM1 IL19 IL16 IL17RE OSMR PSMD8 IL17RB PSMD6 HMOX1 IL31 IL17C PSMD7 IL11RA SOCS2 IL7 PSMD2 IL7R IFNL2 PSMD3 IFNL1 AKT1 IFNL3 PSMD1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A UBE2V1 HSPA8 VAMP2 ICAM1 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAK2 RAG2 RAG1 IL32 CASP3 IL34 IL1RL1 IL33 TGFB1 LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 RORC RORA TNFRSF1A HSP90AA1 CBL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 MAP2K1 HSP90B1 H3C15 STAT3 NFKB1 ITGAX FASLG IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 95%5689877 Josephin domain DUBs JOSD2 UBC RAD23A JOSD1 ATXN3L RPS27A VCP RAD23B PRKN UBA52 ATXN3 UBB SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 95%195721 Signaling by WNT CLTC CLTB FZD7 WNT5B WNT5A ROR1 CLTA ROR2 AP2A1 PRICKLE1 WNT1 FZD1 AP2A2 RYK FZD8 AP2M1 PRKG2 AP2S1 ITPR1 ITPR2 AP2B1 ITPR3 WNT10A DPY30 WNT7B WNT7A BTRC PRKCB RAC1 WNT6 PPP3CA WNT2 PPP3CB GNAT2 PRKG1 PLCB3 WNT2B PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 WNT16 NFATC1 GNAO1 TCF7L2 TCF7L1 HDAC1 LEF1 PIP5K1B TCF7 CTNNB1 ASH2L TNRC6C MOV10 AGO3 AGO4 MYC AGO1 AGO2 RSPO3 TNRC6A TNRC6B TRRAP PSMD8 PSMD6 PSMD7 XPO1 PSMD2 RBX1 PSMD3 AKT1 VPS29 PSMD1 VPS35 WLS VPS26A TMED5 PRKCA TLE5 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 SNX3 PSMA2 CSNK1G2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 RAC3 PSMD13 WNT3A PSMA7 LRP5 KREMEN1 WNT9A PSMB6 KREMEN2 DKK1 PSMB7 DKK2 PSMB4 LRP6 DKK4 SFRP1 PSMB5 CSNK1E SFRP2 WIF1 UBB PSMB2 SOST PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 MEN1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PRKCG GNG10 CHD8 GNG12 CAV1 CBY1 SOX3 GNG11 SOX17 GNG13 XIAP RNF146 SRY SOX6 GNB2 SOX7 SOX4 GNB1 BCL9L RUVBL1 CTNNBIP1 SOX13 MAP3K7 GNB4 USP8 PYGO1 GNB3 BCL9 PYGO2 GNB5 GNGT1 TLE4 TLE2 TLE1 GNGT2 CUL3 TNKS GNG3 SMURF2 GNG2 GNG5 GNG4 GNG7 GNG8 USP34 ARRB2 SCRIB VANGL2 WDR5 AXIN2 RNF43 RBBP5 ZNRF3 RSPO2 HECW1 RSPO1 LGR6 KLHL12 LGR5 WNT3 CCDC88C RSPO4 LGR4 DACT1 WNT8A PPP2R1B H2AX WNT8B PPP2R1A CXXC4 TNKS2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L KMT2B DAAM1 H2BC21 PFN1 EP300 PARD6A SOX2 AKT2 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SOX9 DVL1 DVL2 H2BC12 RUNX3 DVL3 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 FRAT1 H3C15 PPP2R5E FRAT2 H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 H2BC1 H2AC20 RHOA PPP2CA PPP2CB SMURF1 CAMK2A AMER1 CALM1 GSK3B CSNK1A1 AXIN1 APC PORCN CDC73 LEO1 KAT5 CTBP2 CTBP1 CREBBP TERT WNT10B WNT9B SEM1 SMARCA4 WNT4 TLE3 SKP1 CUL1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 95%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 CSPG4 AGRN B3GALT6 GPC1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 BGN HSPG2 DCN BCAN VCAN SDC1 SDC4 SDC2 SDC3 CSPG5 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 95%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MBD3 GATAD2B GATAD2A CHD3 DPF1 HDAC2 DPF2 DPF3 CHD4 SS18L1 ARID1A ARID1B SS18 SMARCB1 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 SMARCC1 MTA1 SMARCC2 MTA3 RBBP7 ACTB SPOCD1 SMARCE1 H2AX ACTL6A H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 PIWIL4 H3-3B H3C8 H2AC8 DNMT3L H2AC6 BCL7A H2AC7 BCL7C H2BC17 BCL7B SMARCA2 H2BC12 SMARCA4 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 C19orf84 H3C15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones HSPA5 NFYA NFYB ATF4 NFYC CALR ATF6 MBTPS1 HSP90B1 MBTPS2 DDIT3 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.2 Ribosome-associated quality control VCP RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 TCF25 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 ZNF598 RPS27 RPS23 ANKZF1 ASCC2 KLHDC10 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 ABCE1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 INTERLEUKIN-27 SIGNALING%REACTOME%R-HSA-9020956.3 Interleukin-27 signaling CRLF1 TYK2 CANX IL6ST JAK2 IL27RA EBI3 STAT3 JAK1 STAT1 IL27 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME DATABASE ID RELEASE 95%4719360 Defective DPM3 causes CDG-1o DPM3 DPM1 DPM2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 95%549127 Organic cation transport SLC22A5 RSC1A1 SLC14A1 SLC14A2 SLC22A4 SLC67A1 SLC22A2 SLC22A3 SLC22A1 RUNX1 SLC22A15 SLC22A16 SLC47A2 SLC47A1 SLC25A26 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RELA NFKB1 BST2 NPM1 ITCH PCBP2 NLRP3 SMAD4 SMAD3 TBK1 IRF3 NFKBIA STING1 UBE2I MAVS TKFC YWHAB FKBP1A RIGI RCAN3 PALS1 YWHAE NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 YWHAQ PYCARD YWHAG YWHAH YWHAZ SFN PPIB TRAF3 TRAF6 UBA52 TLR7 IFIH1 RIPK3 RPS4Y2 KPNB1 RPS27L RPS4Y1 RPS4X RPS15 RPS14 TOMM70 UBB RPS17 RPS15A RPS16 RPS19 UBC SP1 RPS18 RPS3 RPS2 RPS27A RPS11 HNRNPA1 RPS10 BCL2L1 EP300 RPS13 RPS12 RPS9 RPS7 RPS8 PPIA IRAK2 RPS5 RPS6 PSMC6 RPSA RPS3A RUNX1 RPS26 EEF1A1 RPS25 RPS28 KPNA2 PDPK1 RPS29 RPS20 FAU RPS21 RPS24 PPIH RPS27 RPS23 PPIG CAV1 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSME1 PSMB10 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMD9 PSMD4 PSMA5 PSMD5 PSMA6 PAAF1 PSMA3 PSMA4 PSME3 PSMA1 PSME4 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMD12 PSMG4 PSMD11 PSMG1 PSMG2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 95%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBC RPS27A CBL UBA52 MKNK1 SPRY2 MAPK1 MAPK3 BRAF PTPN11 UBB PPP2R1A BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors STAB2 APOA1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CD163 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 ALB IGHV1-69 HSPH1 HYOU1 IGLV2-11 SCARF1 S100A9 IGLV1-40 APOB HBA2 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 HP IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 APOL1 HMGB1 COLEC12 MSR1 COLEC11 SCARA5 HSP90B1 MARCO COL3A1 COL4A2 COL4A1 FTH1 PRDX1 SCGB3A2 MASP1 SPARC FTL V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 HBB V2-19 V1-11 V1-16 V1-13 APOE V2-8 V1-20 CALR V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD36 LRP1 COL1A1 SSC5D COL1A2 STAB1 CD5L SAA1 HPR HPX IGHA1 IGHA2 AMBP JCHAIN PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CCL2 EDNRA CCL1 EDNRB CCL19 PROK2 CCR2 CCL17 AVPR2 PROK1 AVPR1A CCL16 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP NMS PDYN NMU AGTR2 FPR3 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 CCKAR PNOC SSTR3 EDN1 GPR37 ANXA1 EDN2 EDN3 CCKBR NPSR1 GRP NPS PROKR1 PROKR2 KISS1R MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR MT-RNR2 INSL3 F2RL1 INSL5 PENK F2RL2 F2RL3 APLN GPR37L1 KEL PMCH NLN PPY MC1R GHSR MC4R F2R MC3R UTS2 GAL NTS MCHR2 NPB NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R NPY1R APLNR BDKRB2 BDKRB1 QRFPR XCL2 XCL1 PYY HEBP1 CCK GPER1 HCRTR2 HCRTR1 NPY5R KISS1 SSTR1 SSTR2 SSTR4 SSTR5 CORT NPY4R C3AR1 OPRL1 OPRD1 ACKR1 C5AR2 C5AR1 C5 AGT PF4 C3 FPR1 NPY CXCR1 CXCR2 OPRM1 SST OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 95%9012546 Interleukin-18 signaling IL18RAP IL18R1 IL4 IL18BP IL13 IL18 IL37 ALOX5 SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 95%9753510 Signaling by RAS GAP mutants HRAS NRAS KRAS ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 95%114452 Activation of BH3-only proteins YWHAH SFN YWHAZ DYNLL1 DYNLL2 PPP3CC E2F1 BID TP63 PPP1R13B MAPK8 BCL2L11 TFDP1 TFDP2 BAD BBC3 BCL2 PMAIP1 AKT2 BMF YWHAB YWHAE TP73 TP53 AKT1 PPP3R1 TP53BP2 YWHAQ YWHAG AKT3 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 95%420029 Tight junction interactions PARD6G CLDN2 CLDN1 CLDN22 CLDN20 CLDN23 CLDN11 CLDN6 CLDN10 CLDN4 CLDN3 PRKCI CLDN15 CLDN9 CLDN14 CLDN8 CLDN7 CLDN12 CLDN19 PATJ CLDN18 CLDN17 CLDN16 PARD6A F11R CRB3 PARD6B PARD3 CLDN5 PALS1 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 95%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 95%195258 RHO GTPase Effectors ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C S100A9 S100A8 YWHAE YWHAQ YWHAG YWHAH FLNA LIMK2 PRKCB RAC1 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 CTNNB1 CDH1 YWHAB MYL9 XPO1 CYFIP1 NCKAP1 PRKCD AR PRKCA NCF1 SFN YWHAZ NCF2 NCF4 CFTR BRK1 BTK CFL1 CYBB CYBA ACTB NOXO1 MEN1 MAPK14 MAPK11 PAK1 MYLK NCKAP1L WASF1 PAK2 WASF2 BAIAP2 ABI2 NOXA1 ABI1 NOX3 ABL1 NOX1 ROCK1 ROCK2 WIPF1 WIPF2 CYFIP2 WIPF3 NUP107 LIN7B NUP160 CIT IQGAP1 NUP85 PKN3 IQGAP2 IQGAP3 NUP43 RANBP2 SEC13 GOPC CDC25C PKN2 NUP133 PKN1 CDKN1B NUP37 ERCC6L WASL ZWILCH BUB1B ACTG1 CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 MRTFA KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 DAAM1 H2BC21 ZW10 NCK1 PFN1 WAS MAD1L1 PFN2 H3-3B CDCA8 H3C8 PRKCZ H2AC8 PMF1 SKA1 H2AC6 SKA2 PAK3 H2AC7 DSN1 H2BC17 WASF3 DVL1 DVL2 H2BC12 DVL3 H2BC13 SRGAP2 H2BC14 SCAI H2AJ RCC2 KTN1 PDPK1 H2BC15 NDC80 ZWINT H2BC11 DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PIK3C3 H3C15 PPP2R5E NUF2 KIF14 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B RAC2 H2BC5 PPP2R5A H2BC3 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 H2BC1 RHOC RANGAP1 RHOD H2AC20 CKAP5 DYNLL2 RHOQ RHOA RHOB KIF2A KDM1A MAPK1 INCENP PIN1 BIRC5 EVL KIF2C RTKN KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 MAPK3 CENPA AURKB NSL1 CENPC CDC42 PPP2CA RHPN1 PPP2CB RHPN2 BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE CENPF FMNL1 FMNL2 CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ DLG4 SPC24 CALM1 SPC25 MAD2L1 CENPS PLK1 NCOA2 CTNNA1 PPP1CB PPP1R12A PTK2 CLIP1 SIGNAL ATTENUATION%REACTOME%R-HSA-74749.5 Signal attenuation MAPK1 SOS1 SHC1 INS MAPK3 GRB10 IRS1 INSR IRS2 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 95%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) RPS6KA1 JUN H2BC9 H2AZ2 CXCL8 H4C9 VENTX H2BC8 RELA H2BC5 H2BC3 MAPK7 STAT3 H2BC1 CDKN1A NFKB1 CDKN2A H2AC20 MAPK1 CDK2 CEBPB MAPK3 EHMT2 EHMT1 IL6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDKN2D ANAPC11 CDKN2C CDC23 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 CDKN1B ANAPC4 ANAPC5 FZR1 ANAPC1 ANAPC2 IGFBP7 CDK6 IL1A CDK4 H2AX UBB H2AB1 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS CCNA2 CCNA1 H2BC11 RPS6KA3 RPS6KA2 H3C15 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9762293 Regulation of CDH11 gene transcription HOXC8 HEYL FOXF1 SP1 ILF3 ZEB2 SNAI1 PRDM8 BHLHE22 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%1834941 STING mediated induction of host immune responses CGAS TREX1 XRCC6 DDX41 DTX4 XRCC5 TBK1 IRF3 STING1 NLRP4 PRKDC TRIM21 STAT6 MRE11 NLRC3 IFI16 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling ADAR ARIH1 PPP2R5A STAT3 NPM1 HSPA1L DHX9 HSPA2 CHUK SPHK1 EIF2AK2 ISG15 MAP2K6 STAT1 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB FANCC PPP2CA PPP2CB PRKRA TARBP2 UBE2I MAVS SNCA SUMO1 DUS2 TRIM25 CENPS CENPX ILF2 CDK1 ILF3 IKBKG PPP2R1B PPP2R1A PTPN2 DNAJC3 NCK1 FAAP100 FAAP24 HSPA8 FAAP20 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A TP53 UBE2L6 HERC5 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells FGF10 FGF2 EGF FGF4 FGF7 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes LMF1 GPIHBP1 FGF21 MBTPS1 FURIN PCSK6 LIPC CREB3L3 APOC2 PCSK5 ANGPTL3 MBTPS2 APOA4 APOA5 ANGPTL8 ANGPTL4 LPL LMF2 CAM PATHWAY%REACTOME DATABASE ID RELEASE 95%111997 CaM pathway PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 95%111471 Apoptotic factor-mediated response XIAP CARD8 CYCS UACA BAK1 CDKN2A GSDMD GSDME BAX MAPK1 C1QBP AVEN APIP CASP9 MAPK3 CASP7 APAF1 DIABLO CASP3 CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 95%73886 Chromosome Maintenance PCNA RUVBL1 NPM1 WRAP53 PIF1 GAR1 CTC1 CENPW CENPX RUVBL2 OIP5 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 RBBP4 RTEL1 CHTF8 DAXX ATRX RSF1 RBBP7 PRIM2 MIS18A PRIM1 POLA1 H2AX DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 KNL1 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC1 H3-3B STN1 TEN1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 CDK2 ITGB3BP CENPA CENPC FEN1 CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L BLM WRN HJURP RFC5 RFC3 RFC4 TERT RFC2 RPA1 MIS18BP1 RPA2 RPA3 CCNA2 CCNA1 DNA2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 95%3232118 SUMOylation of transcription factors PIAS4 PIAS3 TFAP2B SUMO3 SUMO2 TFAP2C UBE2I PIAS1 CDKN2A SUMO1 MDM2 FOXL2 MITF HIC1 SP3 MTA1 TP53BP1 TP53 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 95%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation FOXD3 CRIPTO DPPA4 ZIC3 EPHA1 FGF2 SALL4 STAT3 SOX2 POU5F1 NANOG SALL1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B2 SRD5A3 HSD3B1 CGA LHB HSD17B3 HSD17B12 SRD5A2 CYP17A1 SRD5A1 POMC SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 95%9839373 Signaling by TGFBR3 RXRA APH1A TGFB1 GIPC1 TGFBR1 PSENEN TGFBR2 NCSTN APH1B PSEN2 PSEN1 ACVR2A INHBA INHA TGFB2 SP1 TIMP2 FGF2 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B TIMP1 MYF5 TCF3 HELLS TCF12 KLF16 ARRB1 ARRB2 RARA MMP14 MMP16 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 95%6804754 Regulation of TP53 Expression TP53 PRDM1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP5 GP9 ADAMTS13 VWF GP1BA GP1BB AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 95%198203 PI3K AKT activation NTRK1 PIK3CB PIK3R2 PIK3R1 NGF PIK3CA IRS1 RHOA IRS2 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629597.5 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA6 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 H2BC1 LIG4 MDC1 PAXIP1 RNF168 NSD2 PIAS4 BRCC3 PRKDC MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 KAT5 UIMC1 H2AX NBN BARD1 H2BC26 H2BC12L H2BC21 RNF8 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2BC15 DCLRE1C RIF1 H2BC11 ATM POLL NHEJ1 POLM TDP2 TDP1 UBE2N SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 AGGREPHAGY%REACTOME DATABASE ID RELEASE 95%9646399 Aggrephagy CETN1 PARK7 UBC DYNC1LI1 CFTR RPS27A DYNC1I1 HSP90AA1 DYNC1LI2 DYNLL1 UBE2V1 PRKN DYNC1H1 UBA52 ARL13B DYNLL2 HDAC6 PCNT HSF1 VCP IFT88 DYNC1I2 UBE2N UBB RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter CRCP TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 POLR1C POLR1D INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease RELA ARPC1B NPM1 ARPC1A ITCH ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 NR3C1 IRAK1 NCKIPSD IL6 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 VAV3 MED4 MED6 MED7 UBE2N VAV1 VAV2 MAPKAP1 NEDD4L C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 V1-11 PTGES3 V1-16 V1-13 MAPK8 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB V2-8 V1-20 V1-9 TAF7L V5-4 FEN1 V1-7 V5-1 V1-5 UBE2I V1-3 V5-6 SUMO1 C1QA C1S UBE2D2 ELOB V4-6 ELOC V4-2 RBX1 V4-1 VHL RNMT CCNH POLR2A ISCU SNAP25 POLR2B POLR2C POLR2D SYT1 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 GNG10 GNG12 GNG11 GNG13 KPNA7 KPNA4 GNB2 KPNA5 GNB1 GBP1 KPNA3 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 CDK8 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 ACTG1 PPP1CC TXNRD1 PML DYNC1LI1 DYNC1LI2 FCGR2A DVL1 DVL2 DVL3 TXN RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 HBB CD33 CHUK TJP1 DYNC1I2 CDC42 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X NFKB2 JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 PRKACG IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 FCGR3A BRD4 RPS18 CRBN RPS3 MYH2 MYO10 IGLC7 RPS2 IGHV3-53 MYO1C RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 PRKAR1B RPS5 PRKAR2B RPS6 PRKAR1A RPSA PRKAR2A RPS3A PRKX RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HBEGF HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E RNF213 ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A GBP2 GBP4 TLR6 IKBKE IRF7 CYFIP1 NCKAP1 BRK1 RAN NEK2 PDIA3 TUBB CYBA VPS36 VPS25 CBX1 SNF8 CHMP1A RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L SUGT1 WASF1 PAK2 IGF1R WASF2 CALM3 CALM2 CAV1 BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A WIPF1 WIPF2 FXYD4 WIPF3 FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 FCGR1A SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C DUSP16 TMPRSS2 WASL SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 NRP1 MAP2K1 MAP2K2 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 ENO1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 PGK1 ARID4B SAP30 MAP2K4 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD MAP2K7 TAB3 TAB2 NFKBIB ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 ARIH1 IFNA13 IFNA14 ADCY9 IFNA16 SAP30L IFNA17 ADCY4 BAG2 MED9 ADCY3 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 FGR GGT5 PATJ VPS39 VPS18 LARP1 ITPR1 VPS11 ITPR2 GGT1 VPS16 ITPR3 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 NOS2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 P2RX7 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 P2RX4 PARP8 TUFM GEMIN4 GEMIN5 CRK GEMIN6 GEMIN7 GNAS GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 GSDMD DNAJC10 NMT1 VPS33B RIPK3 CORO1A IL18 HGS IL1A RAB5A KPNB1 IL1B TLR4 BCAP31 FNTA CHMP4C UPK1A EPCAM CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 STAM RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IL10 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 AHCYL1 TAF9B KPNA2 MAP3K7 H2AC1 STAM2 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 GNAZ CD163 SMAD4 RHBDF2 ADORA2B SMAD3 ADAM17 NFKBIA SCAP MAVS CYFIP2 TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 WASF3 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 DPEP2 CRNKL1 CDC40 DPEP1 ATP6V1H MAPK1 DHX9 CSTF3 CSTF2 ELMO2 MAPK3 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D SRC RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 CALM1 DOCK2 CAMK2G HNRNPH2 DOCK1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CTSG CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 LTF TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 CD9 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 MET ACOT2 STX1A CDH1 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 TXNIP HMOX1 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 C3 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B TRIM27 HSP90AA1 CBL EGFR PLCG1 RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 SFPQ IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 GNAI3 GNAI1 GNAI2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 SH3GL3 EPS15 SH3GL2 SH3GL1 ST3GAL1 ST3GAL2 ST3GAL3 YES1 EEF2 CTSL SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses RELA PPIB NFKB1 BST2 TRAF3 TRAF6 UBA52 ITCH TLR7 IFIH1 RIPK3 KPNB1 PCBP2 UBB TOMM70 NLRP3 UBC RPS27A TBK1 IRF3 NFKBIA STING1 MAVS IRAK2 PPIA TKFC FKBP1A RUNX1 RIGI RCAN3 KPNA2 NPIPB3 NMI CASP1 TRIM25 IKBKE SFTPD SIKE1 PPIH PPIG PYCARD PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 95%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP4 KCNIP3 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A APOL1 COPS3 COPS6 HMGB1 COPS5 COPS8 PRDX1 CHMP3 CHMP6 CHMP7 PLA2G6 V2-11 V3-4 DCTN6 V3-3 DCTN5 V2-17 DCTN1 GJC1 V3-2 DCTN4 GJC2 V2-15 GJA3 V2-19 V1-11 GJA10 GJA5 CLTCL1 GJA4 V1-16 MAN2A1 GJA9 V1-13 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 V2-8 GJB5 V1-20 GJB7 CHM TMED2 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 CD59 DNM3 CD55 V4-6 V4-2 V4-1 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 CD163 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 HP STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 HBB TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 APOA1 COG8 COG7 COG6 COG5 COG4 IGHV3-23 COG3 RAB27B COG2 COG1 IGLV RINT1 RAB30 IGLV2-8 RAB36 IGKV1-16 TF KIF16B IGKV1-17 SAR1B KDELR2 IGKV1-12 KIF20B IGHV3-7 COPB2 IGHV3-9 COPA IGHV3-30 TMED10 ARL1 IGHV3-33 AP2S1 KIF3B AGTR1 IGKV1D-39 MAN2A2 VTI1A LDLR IGKV1D-33 SERPINA1 KIF3C RAB6B IGKV2D-28 RAB39A IGKV4-1 KIF18B IGHV7-81 KIF4B AP2B1 ALPP IGKV2D-30 KIF4A IGHV4-59 ALB COPE IGHV1-69 KIF12 KIF11 USE1 IGLV2-11 BICD1 S100A9 RABEPK IGLV1-40 BICD2 IGLV1-47 KIF15 KIF19 IGLV6-57 IGLV2-14 MAN1A2 F5 IGLV1-44 KIF13B F8 TMED3 KIF1C IGKV3-15 KIF1B IGKV3-11 IGKV2D-40 MAN1A1 IGHV3-11 KIF1A IGHV3-13 TMED7 TMED9 IGLV7-43 IGKV1D-16 NAA30 IGKV1D-12 KIF25 COPZ2 IGLV1-51 IGLV2-23 KIF22 STX4 KIF6 BET1L IGKV3-20 KIF27 COPZ1 SH3KBP1 SLC2A8 IGHV4-34 RAB33B IGHV1-2 KIF9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 CD3G IGHV NAA35 CD3D IGKV2-29 NAA38 VAMP4 IGKV2-28 PAFAH1B3 IGLC3 ARF5 NAPA NAPB IGLC1 NBAS CHRM2 IGLC2 TMF1 STX16 IGKV3D-20 STX18 GOSR1 GOLGA2 NAPG STX10 IGKV2-30 IGLV3-19 CYTH3 ARFRP1 IGHV2-70 IGHV2-5 CYTH2 IGLV3-1 CYTH4 IGHV3-48 CUX1 IGLV3-25 VPS51 CD4 IGLV3-27 VPS53 VPS52 IGKC IGKV1-39 MAN1C1 IGLV3-21 BNIP1 STX6 IGKV1-33 VPS54 CYTH1 RIC1 IGLC7 IGHV3-53 MYO1C GALNT2 ARCN1 IGKV5-2 RGP1 KIF26A IGLC6 IGKV1-5 KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB CALR PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A COL1A1 COL1A2 SSC5D STAB1 CD5L SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 STAB2 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 HSPH1 SNX2 FNBP1L HYOU1 SNX9 SNX5 SCARF1 TBC1D8B PUM1 HBA2 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 HSP90AA1 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 COLEC12 KIF20A MSR1 TMEM115 CNIH2 COLEC11 CNIH3 SCARA5 HSP90B1 MCFD2 MARCO MIA2 COL3A1 PPP6R1 COL4A2 COL4A1 TRAPPC6A FTH1 TRAPPC6B SCGB3A2 SEC22A SEC22C MASP1 FTL SPARC STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF APOE PLIN3 GGA2 GGA1 GGA3 CD36 LRP1 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 SAA1 TGFA HPR HPX IGHA1 IGHA2 EREG AMBP BTC JCHAIN EPGN AKT3 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 CDC7 CDK2 CDC45 PRIM2 PRIM1 POLA1 POLA2 POLE MCM10 RPA1 DBF4 RPA2 RPA4 MCM7 MCM8 POLE4 GMNN RPA3 MCM3 MCM4 POLE2 MCM5 POLE3 MCM6 MCM2 ORC5 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9715370 Miro GTPase Cycle TRAK1 TRAK2 RHOT1 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME%R-HSA-77588.5 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs SLBP LSM10 NCBP1 LSM11 NCBP2 ZNF473 SNRPG SNRPD3 SNRPB SNRPE SNRPF SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants LRP5 KREMEN1 KREMEN2 DKK1 DKK2 DKK4 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade SERPING1 CFD C3 GZMM CFB CLU IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 CR1 C4A IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV ELANE IGKV2-29 IGKV2-28 IGLC3 VTN IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 CD81 C4BPA C4BPB MASP1 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 CD46 C1QB C1QA C1S FCN1 C1R CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC FCN2 FCN3 CRP COLEC10 PROS1 F2 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%9031628 NGF-stimulated transcription SGK1 NAB1 NAB2 LYL1 REST F3 ATF1 DNM2 SRF ARC TRIB1 CDK5R1 TPH1 ATF2 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 SH3GL3 ID1 CDK5 VGF ID4 FOSB EP300 ID3 JUNB CDK5R2 MEF2D TCF12 FOS CHD4 ELK1 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9656255 Defective OGG1 Substrate Binding OGG1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955693 NAGS variants cause NAGS deficiency NAGS TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway CREBBP TBK1 IRF3 TRAF3 EP300 MAVS RNF135 RIGI IFNB1 IFIH1 TRIM25 IKBKE TRIM4 IRF7 SIKE1 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body ABCD4 TCN2 CD320 LRP2 ABCC1 LDLRAP1 TCN1 LMBRD1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres ACD TINF2 PCNA TERF1 TERF2 RUVBL1 POT1 TERF2IP WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 NHP2 ANKRD28 NOP10 PPP6C PPP6R3 BLM RTEL1 CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 RFC5 POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 CHTF18 RFC2 TERT RFC1 STN1 RPA1 TEN1 RPA2 RPA3 CCNA2 CCNA1 DNA2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses GUSB SGSH GNS ARSB GALNS HGSNAT NAGLU HYAL1 GLB1 IDS IDUA DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT FORMATION OF AXIAL MESODERM%REACTOME DATABASE ID RELEASE 95%9796292 Formation of axial mesoderm YAP1 SMAD2 SMAD3 TBXT LEF1 TCF7 TEAD2 NOTO TEAD4 FOXH1 FOXA1 CTNNB1 SHH FOXA2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 95%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBB6 TUBB3 TUBA3E TUBB1 TUBA3D TBCE TUBA3C TUBA8 TUBA1C TUBA4B TUBA1B TUBA4A TUBA1A TUBB4B TUBB4A TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TBCA SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SLC24A2 SLC24A3 SLC8B1 SLC8A1 SLC24A1 SLC8A2 SLC8A3 SRI CALM1 SLC24A5 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%73887 Death Receptor Signaling XIAP RELA MAP3K7 NGF USP4 USP2 MIB2 SPPL2B SPPL2A CLIP3 NSMAF SMPD3 SMPD2 RIPK1 TBK1 IRAK1 ADAM17 NFKBIA TAB1 TAX1BP1 ARHGDIA YWHAE TNFAIP3 RNF31 SPATA2 TNFRSF1A OTUD1 UBE2L3 TRAF2 TNFSF10 TRAF6 PRDM4 FADD BIRC2 BEX3 BIRC3 CFLAR PRKCI USP21 TRIO RASGRF2 OTULIN ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 TRADD ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 CASP8 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN RACK1 TRAF1 ARHGEF3 ARHGEF4 ULK1 TNFRSF10B ARHGEF1 TNFRSF10A ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF TNFRSF10D ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 RBCK1 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 CHUK ECT2 ITGB3BP FAS ARHGEF33 FASLG NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 SHARPIN LINGO1 MAG OMG RTN4 HDAC2 UBE2D2 UBE2D3 IKBKE CASP2 STUB1 BAG4 UBE2D1 MAPKAPK2 UBA52 CYLD OTUD7B IKBKG UBB RIPK2 UBC RPS27A CASP10 TNF OPTN TAB3 TAB2 CASP3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade RPS6KA1 JUN RELA MAP3K7 SLC15A4 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 TASL HMGB1 CASP8 IRF5 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 TLR8 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 95%447115 Interleukin-12 family signaling IL23R STAT3 IL23A RAP1B LMNB1 TCP1 CA1 STAT1 CDC42 CRLF1 CANX IL6ST IL27RA EBI3 HNRNPF IL27 P4HB SNRPA1 IFNG ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 JAK2 STAT4 HNRNPA2B1 IL12B SOD2 IL12A IL12RB1 JAK1 IL12RB2 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA PAK2 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 95%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP CTNNB1 IRF3 EP300 LRRFIP1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9968551 Regulation of GBP-mediated host defense SFN GBP1 CASP1 PIM1 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 95%9690406 Transcriptional regulation of testis differentiation NR5A1 SRY SOX9 PTGDS DHH FGF9 WT1 AMH GATA4 DMRT1 ZFPM2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACSL1 HSD17B4 FADS1 ELOVL5 ELOVL2 ABCD1 SCP2 ELOVL3 ACAA1 ACOT8 ELOVL1 FADS2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 95%8981373 Intestinal hexose absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex PCNA MAX LIN52 CDC6 MYC HDAC1 E2F4 CDC25A E2F5 E2F1 RBBP4 TFDP1 TFDP2 LIN54 TOP2A LIN37 LIN9 RBL2 RBL1 SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB4 FGF2 THBS1 ITGB5 ITGA6 TNC TGFB1 VTN ACTN1 ITGA2 CASK SDC1 SDC4 ITGB3 ITGB1 SDC2 TRAPPC4 SDC3 ITGAV SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF BAIAP2 ABI2 ABI1 RICTOR ROCK1 ROCK2 PRKACG PRKACA PRKACB SPHK1 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 NOS3 PRR5 CRK PXN HSP90AA1 JUP PLCG1 SHB SH2D2A PIK3CB AXL NCK2 NCK1 RASA1 AKT2 PRKCZ PAK3 PRKCB RAC1 HRAS WASF3 BCAR1 VAV3 PDPK1 NRP1 PIK3CA ITGB3 VAV1 VAV2 TRIB3 MAPKAP1 ITGAV PIK3R2 PIK3R1 NRAS THEM4 RHOA CTNNB1 ELMO2 CDC42 MLST8 MTOR SHC2 HSPB1 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA FLT1 FLT4 NCF2 KDR NCF4 VEGFB PTK2B VEGFC VEGFD PGF BRK1 VEGFA MAPKAPK2 CTNND1 CTNNA1 CYBB CYBA MAPKAPK3 NRP2 CDH5 AAMP MAPK14 MAPK11 PAK1 AHCYL1 FYN NCKAP1L WASF1 PAK2 PTK2 WASF2 CAV1 AKT3 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%1169410 Antiviral mechanism by IFN-stimulated genes KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ARIH1 FURIN NPM1 OAS2 EIF2AK2 SPHK1 ISG15 MAP2K6 STAT1 FANCC PRKRA IRF3 TARBP2 MAVS RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 CENPX NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 FLNA PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 KPNB1 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B EIF4E2 FNTA FLNB MX2 DNAJC3 MX1 EIF4G3 EIF4G2 NCK1 EIF4A2 EIF4A1 UBE2L6 EIF4A3 HERC5 UBE2N ADAR PPP2R5A STAT3 HSPA1L DHX9 PIN1 HSPA2 CHUK MAPK3 HSPA1B EIF2S2 EIF2S1 EIF2S3 IKBKB PPP2CA PPP2CB EIF4E UBE2I SNCA GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 CASP1 NUP214 CENPS SFN ABCE1 UBE2E1 UBA52 CDK1 ILF3 JAK1 ACTB IKBKG UBB UBC PTPN2 RPS27A FAAP100 HSPA8 FAAP24 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839128 FGFR4 mutant receptor activation FGFR4 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%1632852 Macroautophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B CHMP4A GABARAP CHMP2B CHMP2A UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A CHMP3 ATG12 ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B DYNLL2 TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 WIPI1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC25A10 SLC5A8 SLC5A12 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 95%5654720 PI-3K cascade:FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 95%216083 Integrin cell surface interactions COL4A2 COL18A1 COL4A1 ITGA5 ITGA3 ITGA9 COL16A1 ITGA1 ITGB8 COL13A1 ITGB5 ITGA6 JAM2 TNC JAM3 COMP IBSP SPP1 FBN1 ITGAX ITGB6 ITGA2 COL23A1 HSPG2 ITGA8 COL4A4 ITGA7 ITGAL COL4A3 VCAM1 LUM CD47 ITGA11 ITGA4 CD44 COL9A1 ITGAE COL9A3 PECAM1 COL9A2 AGRN ITGB7 CDH1 ITGAD KDR THBS1 FN1 VTN ITGA10 FGB FGA ITGAM ITGB2 FGG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 F11R BSG ITGB3 ITGB1 ITGA2B ITGAV PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 95%112308 Presynaptic depolarization and calcium channel opening CACNB4 CACNG2 CACNA2D2 CACNG4 CACNA1B CACNA1A CACNA1E CACNB2 CACNA2D1 CACNA2D3 CACNB1 CACNB3 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 95%1236975 Antigen processing-Cross presentation FCGR1BP SEC61A2 SEC61A1 TIRAP TAPBP SEC22B B2M HLA-A TLR1 S100A9 PSMB10 S100A8 TLR2 FCGR1A STX4 CD14 TLR4 LY96 HMGB1 ITGAV HLA-H ITGB5 HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 CHUK LNPEP IKBKB MYD88 CD207 CALR CTSS MRC2 MRC1 VAMP8 PSMD8 PSMD6 TLR6 PSMD7 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 NCF1 NCF2 PSMA5 NCF4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 CYBB FGA PSMB4 TAP2 CYBA FGG PSMB5 IKBKG TAP1 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSV CTSL FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.3 FGFR2 ligand binding and activation FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGFBP3 FGFBP1 FGFBP2 FGF23 FGF22 FGF16 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%5656169 Termination of translesion DNA synthesis PCNA UBA52 POLH USP10 PCLAF USP43 REV1 ISG15 POLI UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 UBA7 RPA1 RPA2 POLE4 RPA3 UBE2L6 TRIM25 POLE2 POLE3 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 95%165160 PDE3B signalling AKT2 PDE3B NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling OTUD5 ATG5 ATG12 UBE2D1 TRAF3 UBA52 UBE2K CYLD ITCH PIN1 IFIH1 ISG15 TRIM4 PCBP2 UBB UBC RPS27A NLRX1 TBK1 IRF3 NLRC5 UBA7 MAVS RNF125 RNF135 TAX1BP1 RNF216 UBE2D2 RIGI UBE2D3 TNFAIP3 UBE2L6 TRIM25 IKBKE HERC5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases TP63 TP73 CASP10 TP53 CASP6 ATM CASP1 CASP2 PIDD1 APAF1 NLRC4 CRADD FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT6A CCT7 CCT4 CCT3 TCP1 ACTB CCT2 CCT8 CCT6B FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G ESRP1 POLR2H POLR2I POLR2J POLR2K POLR2L RBFOX2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 NCBP1 NCBP2 HNRNPA1 PTBP1 HNRNPM HNRNPF HNRNPH1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 95%114516 Disinhibition of SNARE formation PRKCB PRKCA STX4 PRKCG STXBP3 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 95%380287 Centrosome maturation CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 CDK11A ODF2 CEP152 CDK11B MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL11B SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A BCL7A DPF2 BCL7C BCL7B SMARCA4 SMARCC1 SMARCC2 ARID1A SMARCE1 ACTB RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling CREBBP RBPJ MAML2 MAML1 KAT2B KAT2A HES1 SNW1 EP300 JAG1 RUNX3 MAMLD1 MAML3 NOTCH1 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.4 Processive synthesis on the lagging strand LIG1 PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 95%9839394 TGFBR3 expression RXRA SP1 TNRC6C SMAD4 MOV10 SMAD3 MYCN AGO3 AGO4 EP300 MYOG TGFBR3 AGO1 MYOD1 AGO2 MYF6 TNRC6A TCF4 TNRC6B MYF5 TCF3 HELLS TCF12 KLF16 RARA SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 95%187015 Activation of TRKA receptors NTRK1 NTRK2 ADORA2A NGF ADCYAP1 ADCYAP1R1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 95%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 95%9726842 Gain-of-function MRAS complexes activate RAF signaling MRAS ARAF SHOC2 RAF1 PPP1CB PPP1CC BRAF YWHAB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.7 Metabolism of polyamines PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM ADRM1 OAZ3 PAOX AZIN2 AZIN1 PSMC5 AGMAT PSMC6 SEM1 PSMC3 SMS PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 95%392170 ADP signalling through P2Y purinoceptor 12 GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 GNAT3 GNAI3 GNAI1 GNAI2 GNG10 P2RY12 GNG12 GNG11 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.4 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029485 Role of phospholipids in phagocytosis IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A PIK3CA IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 PLD4 V2-19 V1-11 PLD3 V1-16 V1-13 PLD2 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 PRKCD PLPP5 PLPP4 SYK AHCYL1 PRKCE DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME%R-HSA-112315.8 Transmission across Chemical Synapses AP2A1 ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 GAD1 ADCY8 GAD2 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB SLC6A3 COMT SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 RASGRF2 PRKAR1B SLC38A2 PRKAR2B PRKCB PRKAR1A MAOA RAC1 PRKAR2A CACNA2D2 PRKX SLC38A1 SYN1 PLCB3 CACNB2 SLC6A12 PLCB1 PLCB2 ARHGEF9 PRKAA1 PRKAA2 ACHE PRKAG1 PRKAG2 PRKAG3 STX1A PRKAB2 PRKAB1 BCHE PRKCA SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT SLC6A1 CPLX1 RIMS1 ALDH5A1 DNAJC5 GIT1 HSPA8 VAMP2 CAMKK1 CAMKK2 KPNA2 PRKCG ALDH2 GNG10 NBEA RPS6KA3 GNG12 RPS6KA2 GNG11 TSPOAP1 RPS6KA1 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 MYO6 GNG3 GNG2 GNG5 GNG4 GNG7 MDM2 GNG8 RASGRF1 KIF17 RPS6KA6 CASK LIN7A LIN7C PPM1E LIN7B PPM1F GRIA3 GRIA4 GRIN3B GRIN3A APBA1 CAMK1 UNC13B SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 CHRNA9 SYN3 SYN2 HRAS SLC6A11 PDPK1 ARL6IP5 CACNA2D1 CACNA2D3 NRAS CHAT GRIP1 MAPK1 GNAT3 SLC6A4 CHRNB2 NSF CHRNB4 CHRNB3 GABRG3 GRIP2 GABRG2 SLC18A3 CHRNA1 CHRNA3 SLC17A7 CHRNA2 MAPK3 CHRNA5 CHRNA4 CACNB1 CHRNA7 CACNB3 CHRNA6 EPB41L1 CACNB4 TSPAN7 NAAA GABRB3 TOMT GABRB2 CACNA1B GABRB1 CACNA1A GRIK5 CACNA1E GRIK3 GRIK4 GRIK1 GRIK2 GRIA1 GABRR3 CAMK2B GABRR2 GRIA2 GABRR1 CAMK2D NPTN SRC ACTN2 HTR3E HTR3C CAMK2A HTR3D NRG1 GRIN2C HTR3A GRIN2B HTR3B PICK1 NRGN GRIN2D GNAI3 AKAP5 GRIN1 GNAI1 DLG1 GRIN2A NCALD GNAI2 DLG2 CHRND DLG3 LRRC7 GLRA1 DLG4 CACNG8 NEFL GLRA2 CALM1 GLRA3 CHRNG CAMK2G CHRNE CACNG2 CACNG3 CACNG4 KCNJ2 KCNJ3 KCNJ4 GABRA2 GABRQ GABBR2 GLS2 KCNJ5 GABRA1 KCNJ6 GABBR1 KCNJ10 GLS GABRA6 KCNJ12 KCNJ9 GABRA5 GABRA4 GLUL GABRA3 KCNJ15 KCNJ16 GLRB CAMK4 SLC5A7 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption MGAM SLC5A1 SLC2A5 SLC2A2 SI CLPS LCT PNLIP ALPI RSC1A1 PNLIPRP1 PNLIPRP2 CHIA AMY2A AMY1A AMY2B TREH GUCY2C AMY1B AMY1C GUCA2B CEL GUCA2A CHIT1 LIPF PIR PNLIPRP3 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport DYNLL1 DYNLL2 IFT172 KIFAP3 IFT52 IFT57 DYNC2H1 IFT140 WDR35 IFT88 KIF3A TTC21B WDR19 IFT122 KIF3B KIF3C DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 KIF17 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 TNPO1 CLUAP1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 95%69231 Cyclin D associated events in G1 CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MTIF2 MRPS25 MTIF3 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MRPS17 MRPS15 MRPS16 MTFMT MRPS14 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 95%9754706 Atorvastatin ADME PON3 ABCB1 UGT1A3 SLCO1B1 SLCO1B3 PON1 ABCC2 CYP3A4 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 95%8953854 Metabolism of RNA DDX21 ETF1 GSPT2 GSPT1 DDX6 LSM1 PATL1 EDC3 EDC4 DCP1B UPF3A CNOT10 SMG1 SMG9 SMG7 SMG8 SMN2 SMG5 CNOT11 SMG6 UPF2 UPF1 PNRC2 NOP58 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 TYW5 GEMIN8 TYW3 TRMT5 DDX20 TYW2 TYW1 LCMT2 ADAR ADARB1 TNKS1BP1 RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RPLP0 RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 LTV1 RRP1 GTF2H4 GTF2F2 FTSJ3 GTF2H5 EBNA1BP2 ISG20L2 CDK7 ERI1 ERCC3 LAS1L ERCC2 MNAT1 NOL12 RBM28 NOB1 RIOK2 RIOK1 TEX10 SENP3 GNL3 C1D NIP7 NOL9 EXOSC10 PES1 RIOK3 WDR18 WDR12 BYSL APOBEC1 BOP1 TSR1 APOBEC3C APOBEC2 MPHOSPH6 APOBEC3H APOBEC4 A1CF APOBEC3A APOBEC3B XRN2 HBS1L NT5C3B SKIC3 DCPS SKIC2 SLIRP MTPAP LRPPRC CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 NOP56 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PPP2R1A TP53RK STEEP1 TCERG1 EIF4A3 GPATCH1 RPS27 HNRNPU HNRNPR CCAR1 GLE1 PNN SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 PRMT5 AQR METTL3 CRNKL1 CDC40 DDX39A ZC3H11A SARNP ZNF830 SF1 SLBP DHX8 DHX9 PRKRIP1 CSTF3 CSTF2 CWF19L2 SNU13 RNPC3 WDR77 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 PPP2CA ZRSR2 PRPF38A UPF3B NOP2 MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 NKAP PRPF19 PQBP1 UBL5 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 PRPF18 HNRNPH1 SDE2 TUT1 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 FYTTD1 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 PRPF31 TENT4A PDCD7 CWC25 CASC3 CWC27 EFTUD2 PPP1CB RBMX2 PAPOLG CWC22 PAPOLA LSM10 SNIP1 NCBP1 LSM11 MTREX NCBP2 TXNL4A PPP2R2A SNRNP35 IK SNRPN THOC1 PRP4K THOC3 ZCRB1 THOC2 THOC5 WBP11 THOC7 THOC6 LENG1 SEM1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 PHAX SNRNP27 PPIE TRUB2 SRSF3 MTERF3 SNRPE NSUN4 SRSF4 FASTKD2 PPIH MTERF4 PPIG SNRNP25 TFB1M SNRPF MRM1 SRSF5 MRM2 SNRNP200 MRM3 SRSF6 RCC1L SNRPC RPUSD4 SRSF7 NGRN SRSF8 RPUSD3 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CPSF4 CHTOP CCDC12 CPSF1 FUS ALYREF CPSF3 YJU2 CPSF2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 NXF2B ISY1 RBM25 NXT1 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 METTL14 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 LUZP4 POLDIP3 SRSF1 PRCC DDX23 WBP4 CSTF2T U2AF1 U2AF1L4 NXF1 RNF113A FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW WTAP CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 RPS4Y2 SNRNP48 RPS27L BUD13 RPS4Y1 TRMT10C PPIL3 PRORP PPIL4 RPS4X ELAC2 RPS15 FAM50A RPS14 TRNT1 HSD17B10 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 HNRNPA1 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 PAN2 PAN3 FASTKD5 POP5 TBRG4 POP7 CLNS1A OSGEPL1 SNUPN POP1 RPP30 POP4 RTCB TSEN2 TSEN54 ALKBH8 THG1L TRMT44 DDX39B RPP38 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 GTPBP3 RPP21 RPP25 DDX1 THADA OSGEP C2orf49 RPP40 TRMT9B YRDC EPRS1 TRMT13 TRMT11 TRMU EIF4E QNG1 EIF4B TSEN15 WDR4 ZBTB8OS MTO1 TRMT112 NSUN2 GRSF1 NSUN6 DUS2 YWHAB QTRT1 HSPB1 GON7 ELAVL1 PSMD8 QTRT2 PSMD6 CTU2 ZFP36 CTU1 PSMD7 TSEN34 URM1 XPO1 PSMD2 LAGE3 KHSRP RPP14 PSMD3 TRDMT1 AKT1 RTRAF PSMD1 TRMT10A ADAT1 TNPO1 NUP214 TPRKB TRMT1 DIS3 PRKCD ADAT3 PRKCA TRIT1 ADAT2 YWHAZ PSMA5 XPOT PSMA6 TRMT6 PSMA3 FAM98B PSMA4 TRMT61A PSMA1 TRMT61B XRN1 RAN PSMA2 MAPKAPK2 PABPC1 UBA52 DCP2 PSMD12 PSMD11 SET PSMD14 ANP32A PSMD13 PARN PSMA7 ZFP36L1 PSMB6 EXOSC7 PSMB7 EXOSC6 PSMB4 CSNK1D EXOSC5 PSMB5 CSNK1E EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 HSPA8 TNFSF13 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 CNOT6L PSMC4 PSMC1 PSMC2 DCP1A HSPA1A EIF4G1 ZNF473 IGF2BP1 CPSF7 SRRM1 TRA2B RBBP6 HNRNPC RBMX DDX41 GAR1 NHP2 NOP10 DKC1 PELP1 ZC3H4 ZC3H3 EIF4A2 REXO2 IGF2BP3 EIF4A1 DDX49 TUT7 IGF2BP2 DDX47 TUT4 WDR3 DXO FCF1 ZCCHC7 NAT10 YTHDC1 THUMPD1 YTHDC2 PWP2 ZC3H18 WDR46 PNPT1 WDR43 RBM27 RRP9 RBM26 FBL TENT4B BUD23 SUPV3L1 UTP14A ZFC3H1 UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 PAIP1 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 RPLP1 DHX37 RPL34 RRP36 RPL10L UTP20 RPL8 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 UTP3 RPL18A PNO1 RPL36AL RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A WDR82 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 SKIC8 ZCCHC8 NCL TGS1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 95%68882 Mitotic Anaphase CDCA5 SIRT2 TUBB8 IST1 VRK1 LEMD2 TUBB8B ESPL1 KPNB1 SPAST CC2D1B PTTG1 CHMP4C CHMP4B CHMP4A CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EMD PSMA7 LBR PSMB6 PSMB7 PSMB4 PSMB5 LEMD3 UBB PSMB2 PSMB3 TUBB6 TUBB3 TUBB1 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 PSMC3 TUBA4B PSMC4 PSMC1 TUBA4A PSMC2 CCNB2 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E TUBA3D TUBA3C ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 NUP160 NUP85 NUP62 BANF1 NUP43 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP93 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 RCC1 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 PDS5B SMC1A VPS4A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 SIGNALING BY BMP%REACTOME%R-HSA-201451.6 Signaling by BMP ACVRL1 BMPR2 AMHR2 GDF2 UBE2D1 SMAD9 SMAD5 GREM2 ZFYVE16 CER1 BMPR1B BMPR1A AMH NOG ACVR2B ACVR2A INHBA INHA CHRDL1 SKI SMAD1 SMAD4 SMURF2 SMAD7 SMURF1 SMAD6 TGFBR3 BMP2 UBE2D3 FSTL1 BMP10 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 95%9930044 Nuclear RNA decay ZFC3H1 PABPN1 SRRT TENT4A EXOSC7 EXOSC6 EXOSC5 EXOSC4 PAPOLG ZCCHC8 EXOSC9 NCBP1 MTREX NCBP2 C1D EXOSC8 EXOSC10 EXOSC3 EXOSC2 EXOSC1 RBM7 MPHOSPH6 ZC3H4 ZC3H3 WDR82 XRN2 DXO ZCCHC7 YTHDC1 YTHDC2 ZC3H18 RBM27 RBM26 TENT4B DIS3 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis FTH1 FTL BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN AP3S1 TPD52 CLINT1 DNM2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 IGF2R DTNBP1 ARF1 GOLGB1 NAPA RAB5C TGOLN2 AP3B1 TXNDC5 OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 95%3065676 SUMO is conjugated to E1 (UBA2:SAE1) SAE1 SUMO3 SUMO2 SUMO1 UBA2 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 95%1300642 Sperm Motility And Taxes HVCN1 KCNU1 CATSPERB CATSPER1 CATSPERD CATSPER3 CATSPERG CATSPER2 CATSPER4 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis CYP11B1 HSD3B2 HSD3B1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYP11B2 POMC SERPINA6 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 95%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP5 GP9 F9 F10 GGCX F8 GP1BA GP1BB F11 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 95%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex GPS2 NCOR2 NCOR1 TBL1XR1 TBL1X HDAC3 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 95%9022534 Loss of MECP2 binding ability to 5hmC-DNA REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 95%4641265 Repression of WNT target genes TLE1 TLE5 TLE3 TCF7L2 TCF7L1 CTBP2 HDAC1 CTBP1 LEF1 TLE4 TCF7 TLE2 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 95%5578998 Defective OPLAH causes OPLAHD OPLAH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 95%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 95%5654708 Downstream signaling of activated FGFR3 FGF18 SOS1 FGF1 FRS3 FGF2 FGF4 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GNG13 GNB2 GNAQ GNB1 ADCY9 GNB4 PIK3R2 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PANX1 PRKACG PRKACA CTNNB1 PRKACB PECAM1 MLST8 GNG3 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MTOR NOS3 PRR5 AKT1 CALM1 FLT4 KDR TRPV4 GNAS PKN2 CAPNS1 CAPNS2 CAPN2 RAMP2 PIK3CB CALCRL ADM TLN1 CDH5 VCL PIEZO1 PIK3CD PRKAR1B PRKAR2B PRKAR1A PRKAR2A FYN PDPK1 GNG10 PIK3CA P2RY2 MMP14 GNG12 MAPKAP1 GNG11 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RHBG MMGT1 ADD3 DMTN RHCG ADD2 ADD1 TUSC3 CTNS MAGT1 PIP LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E NIPAL4 NIPAL1 NIPAL2 NIPAL3 RHAG AZGP1 ANKH MRS2 SLC66A1 NIPA1 NIPA2 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 95%373753 Nephrin family interactions IQGAP1 PIK3CB NCK2 PIK3R2 NCK1 PIK3R1 ACTN3 KIRREL3 ACTN2 KIRREL1 KIRREL2 ACTN1 MAGI2 FYN CD2AP SPTAN1 NPHS1 CASK WASL PIK3CA ACTN4 SPTBN1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 95%9764265 Regulation of CDH1 Expression and Function ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism ACOX2 EHHADH ACBD5 AMACR ACOX3 SLC27A2 ACOT4 ACOXL NUDT7 CROT CRAT PECR HSD17B4 HACL1 ABCD1 DECR2 NUDT19 HAO2 ACBD4 ACAA1 PHYH ACOT8 SLC25A17 DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020702 Interleukin-1 signaling RELA MAP3K7 MAP2K6 IL1R1 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 USP14 BTRC NOD1 IL1A IL1B PELI1 NOD2 USP18 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N NFKB1 CHUK IKBKB SQSTM1 MYD88 IRAK3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 IL1RN PSMD14 IL1R2 PSMD13 NFKB2 TOLLIP PSMA7 PSMB6 PSMB7 PSMB4 MAP3K3 NKIRAS1 NKIRAS2 PSMB5 MAP3K8 IKBKG UBB IKBIP RIPK2 PSMB2 MAP2K4 PSMB3 IRAK4 UBC PSMB1 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER ADRM1 IRAK2 TIFA PSMC5 S100A12 PSMC6 SEM1 PSMC3 PSMC4 APP S100B PSMC1 PSMC2 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB CUL1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.6 Choline catabolism DMGDH CHDH SARDH ALDH7A1 BHMT SLC44A1 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-9651496.5 Defects of Formation of Fibrin Clot (Clotting Cascade) GP5 GP9 SERPING1 KLKB1 GP1BA F9 F10 TPST2 GGCX TPST1 F8 F2 VWF GP1BB F12 F11 PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression CXCL8 DCP2 HSPA5 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EIF2S2 EXOSC4 EIF2S1 EIF2S3 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP EIF2AK3 DIS3 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960525 CASP5-mediated substrate cleavage IL18 CASP5 IL1B GSDMD CASP3 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.3 Serotonin and melatonin biosynthesis TPH2 DDC ASMT AANAT TPH1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.8 Transcriptional regulation by small RNAs H2BC9 H2AZ2 POLR2A H4C9 POLR2B H2BC8 POLR2C H2BC5 POLR2D H2BC3 POLR2E RAN POLR2F H2BC1 POLR2G POLR2H POLR2I POLR2J H2AC20 POLR2K POLR2L IPO8 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B AGO1 H3C8 AGO2 H2AC8 TNRC6A H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 95%205025 NADE modulates death signalling YWHAE NGFR NGF CASP2 BEX3 CASP3 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME DATABASE ID RELEASE 95%5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 95%2408557 Selenocysteine synthesis RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 SEPHS2 SECISBP2 EEFSEC RPS4Y2 SEPSECS RPS27L PSTK RPS4Y1 RPS4X RPS15 RPS14 RPS17 SARS1 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG PNPLA3 PNPLA2 DGAT2 MGLL DGAT1 DGAT2L6 AWAT2 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 95%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism PRSS1 TCN2 CD320 ABCC1 LDLRAP1 CTRB2 CUBN CBLIF MMAB CTRB1 AMN MMACHC MMADHC ABCD4 MTR MTRR LRP2 PRSS3 MMAA MMUT TCN1 LMBRD1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654726 Negative regulation of FGFR1 signaling CBL UBA52 FGF20 ANOS1 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A PPP2CA PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 FRS2 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 95%6806834 Signaling by MET SOS1 ITGA3 STAT3 USP8 PIK3R1 NRAS PTPRJ RAP1B ITGA2 RAP1A STAM2 MET PTPN1 PTPN11 GGA3 SPINT1 HPN SPINT2 SRC HGFAC LRIG1 CRK LAMA5 SH3KBP1 LAMA2 LAMB3 LAMC3 CBL LAMB2 LAMA1 LAMA4 UBA52 LAMA3 LAMB1 STAM LAMC2 LAMC1 ARF6 RAB4A RAB4B DOCK7 HGS RANBP9 UBB RANBP10 RAPGEF1 UBC PTPN2 MUC20 RPS27A SH3GL3 EPS15 TNS4 SH3GL2 TNS3 SH3GL1 RAC1 HRAS GAB1 HGF PTK2 CRKL PIK3CA ITGB1 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 95%5578996 Defective CYP27A1 causes CTX CYP27A1 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 95%111885 Opioid Signalling GNG13 GNB2 GNAQ GNB1 PPP2R5D ADCY9 GNB4 GNAL GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 MAPK1 GNGT2 GNAT3 PRKACG PRKACA PRKACB PLA2G4A PPP2CA PPP2CB GNA14 PPP1R1B PDE1B GNG3 PDE1A GNA15 CDK5 ITPR1 ITPR2 GNG2 CAMK2B ITPR3 GNG5 GNG4 CAMK2D GNG7 GNA11 GNG8 PDYN CAMK2A PDE4A PDE4D PDE4C GNAI3 GNAI1 GNAI2 OPRM1 CALM1 CAMK2G PRKCD PRKCA PLCB4 POMC PPP3CC PPP1CA PPP2R1B PPP2R1A PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX PPP3CA CAMKK1 PPP3CB CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 PLCB2 GNG10 NBEA PPP3R1 GNG12 GNG11 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 95%5654687 Downstream signaling of activated FGFR1 FLRT1 SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FLRT3 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FLRT2 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%1483206 Glycerophospholipid biosynthesis MBOAT7 MBOAT1 DDHD2 AGPAT2 MBOAT2 DDHD1 LPGAT1 PITPNB CPNE7 CPNE6 GPAM CPNE1 CPNE3 MFSD2A PISD PLA2G4A PLA1A PGS1 PTDSS2 PTDSS1 TMEM86B PEMT CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 PLD1 HADHB HADHA PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLA2G2A PLAAT5 PLAAT4 PNPLA8 LIPI LIPH ETNPPL PNPLA3 STARD7 PLB1 PLBD1 MIGA2 MIGA1 PLA2G3 PLA2G15 PHOSPHO1 PLA2G5 PLA2G10 PLA2G6 GPD1 PTPMT1 CHAT PLD4 PLD6 PLD3 CHKB CHKA STARD10 GPAT2 DGAT2 DGAT1 DGAT2L6 CRLS1 ACHE LPCAT1 PLD2 OSBPL10 ALPI GPD2 GNPAT PCTP LPIN1 LPIN2 MGLL PLA2G4F LPIN3 PLA2G4D PLA2G4E GPAT4 PLA2G4B PLA2G4C GPAT3 GPCPD1 CEPT1 AGPAT5 BCHE AGK PLA2G1B LPCAT4 AGPAT1 ETNK2 SELENOI LPCAT3 AGPAT3 ETNK1 AGPAT4 LPCAT2 LCLAT1 PLA2G2F PLA2G2D PLA2G2E PCYT2 PGP PLA2R1 CHPT1 GPD1L ABHD4 ABHD3 OSBPL8 CDS1 PITPNM1 PITPNM3 PNPLA2 OSBPL5 PITPNM2 CDIPT ACP6 CSNK2A1 PLA2G12A CSNK2A2 TAFAZZIN CSNK2B AWAT2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 95%9031525 LXRs regulate gene expression to limit cholesterol uptake RXRA NR1H2 NR1H3 RXRB MYLIP REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 95%6804759 Regulation of TP53 Activity through Association with Co-factors PHF20 AKT2 POU4F1 POU4F2 TP63 TP73 PPP1R13B TP53 PPP1R13L AKT1 TP53BP2 BANP AKT3 ZNF385A ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 95%9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDKN1A CDC23 UBE2S CDC26 CDKN1C CDC27 RB1 CDC16 CDKN1B CCND3 ANAPC4 FZR1 ANAPC5 CCND2 ANAPC1 CCND1 E2F1 ANAPC2 E2F2 E2F3 CDK2 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 ANAPC15 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 95%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J FGF20 POLR2K POLR2L FGF23 GTF2F1 FGF22 GTF2F2 FGF16 NCBP1 FGF18 NCBP2 FGF1 FGF10 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 95%2424491 DAP12 signaling SOS1 PIK3R2 PIK3R1 KLRK1 NRAS PLCG1 BTK HLA-E GRAP2 LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.5 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 MYD88 TLR7 IRAK1 UBE2V1 TRAF6 IRF7 TLR9 UBE2N MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%193704 p75 NTR receptor-mediated signalling RELA NGF SMPD2 IRAK1 ADAM17 NFKBIA ARHGDIA YWHAE TRAF6 PRDM4 BEX3 PRKCI TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 SORCS3 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NFKB1 ARHGEF5 NGEF ARHGEF6 HDAC1 ARHGEF26 MAGED1 KALRN APH1A RHOA HDAC3 FGD1 PSENEN FGD2 NCSTN GNA13 APH1B FGD3 PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ECT2 ITGB3BP ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 MYD88 LINGO1 MAG OMG RTN4 HDAC2 CASP2 UBA52 UBB RIPK2 UBC RPS27A CASP3 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 95%163210 Formation of ATP by chemiosmotic coupling ATP5MC2 ATP5MC3 ATP5PB ATP5F1C ATP5MK ATP5F1D MT-ATP8 ATP5MJ ATP5F1E MT-ATP6 ATP5MC1 ATP5MG ATP5PO ATP5MF ATP5ME DMAC2L ATP5F1A ATP5F1B ATP5PF ATP5PD MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RPS6KA1 JUN RELA MAP3K7 MAP2K6 IRAK1 NFKBIA TAB1 TRAF2 TRAF6 CD14 USP14 BTRC TLR7 NOD1 PELI1 NOD2 USP18 PPP2R1B TLR4 PPP2R1A TICAM2 TICAM1 LY96 TNIP2 HMGB1 CASP8 MAP2K1 UBE2N TLR9 DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAPK3 ATF2 IKBKB PPP2CA MYD88 PPP2CB MEF2C IRF7 MAPKAPK2 UBA52 NFKB2 ATF1 ECSIT NKIRAS1 NKIRAS2 MAP3K8 IKBKG MAP2K3 UBB IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 TP53 NFKBIB FOS ELK1 MEF2A RPS6KA3 RPS6KA5 CUL1 RPS6KA2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 95%210993 Tie2 Signaling PIK3CB SOS1 ANGPT4 SHC1 ANGPT2 ANGPT1 PIK3R2 PIK3R1 TEK DOK2 NRAS HRAS GRB7 PIK3CA PTPN11 GRB14 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 95%173107 Binding and entry of HIV virion CCR5 CXCR4 CD4 PPIA LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.4 Lagging Strand Synthesis LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 FEN1 RFC2 RFC1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.4 CDK-mediated phosphorylation and removal of Cdc6 CDC6 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 95%5694530 Cargo concentration in the ER PREB STX5 LMAN2 FOLR1 CTSZ SEC24D CTSC SEC24C COL7A1 SAR1B MIA3 TMED10 SEC22B TMED2 SEC23A SERPINA1 AREG GRIA1 GOSR2 LMAN1 LMAN1L LMAN2L CD59 TGFA F5 F8 CNIH1 SEC24B CNIH2 CNIH3 MCFD2 SEC24A MIA2 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL ETF1 RPL36 GSPT2 RPLP2 GSPT1 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A UPF1 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 NCBP1 RPS19 NCBP2 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665348 Signaling by ERBB2 ECD mutants ERBIN SOS1 HSP90AA1 SHC1 EGF ERBB2 PIK3R1 EGFR CDC37 NRAS PLCG1 HRAS GAB1 PIK3CA REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion GMPR DIAPH1 CEACAM1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669937 Drug resistance of KIT mutants KIT PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion UBC RPS27A RAB7A VPS33B CORO1A HGS RAB5A UBA52 UBB LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 95%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA BCKDHB DBT ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.8 Estrogen biosynthesis AKR1B15 HSD17B14 HSD17B11 HSD17B1 HSD17B2 CYP19A1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT5A STAT5B LYN STAT3 PIK3R2 PIK3R1 NRAS YES1 LCK HRAS FYN JAK2 KIT STAT1 PIK3R3 PIK3CA DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 95%418889 Ligand-independent caspase activation via DCC APPL1 DCC UNC5A DAPK1 UNC5B DAPK2 DAPK3 CASP9 MAGED1 CASP3 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 95%187042 TRKA activation by NGF NTRK1 NGF DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 95%5632987 Defective Mismatch Repair Associated With PMS2 MLH1 PMS2 FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 STAT5A STAT5B CBL CDKN1A PIK3R1 GRB2 NRAS UBA52 GOLGB1 MYO18A FLT3 ETV6 UBB PTPN11 UBC RPS27A BCL2L1 TRIP11 PIM1 HRAS ZMYM2 FLT3LG GAB2 PIK3CA SPTBN1 NOX4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 95%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 PTGR1 CYP4A22 CYP4B1 ALOX5AP MAPKAPK2 DPEP2 DPEP1 GGT1 ABCC1 ALOX15 CYP4F22 ALOX5 LTA4H LTC4S CYP4F3 CYP4F8 CYP4F2 CYP4A11 CYP4F11 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 RHOC CDKN1B PPP1R12A RHOA RHOB RAC1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 MYL9 PPP1R12B DLG4 PPP1CB PRC1 CIT CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 95%9960519 CASP4-mediated substrate cleavage IL18 IL1B CASP4 GSDMD CASP3 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport PLEKHA8 GLTP CPTP CLN3 ESYT1 ARF1 ESYT3 ESYT2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 95%9664424 Cell recruitment (pro-inflammatory response) C3 RELA C3AR1 NFKB1 HSP90AB1 GSDMD NFKB2 CTSG IL18 IL1A IL1B NLRP3 MEFV PSTPIP1 HMOX1 TXNIP NT5E ENTPD1 ENTPD5 SUGT1 TXN CASP1 P2RX7 PYCARD P2RX4 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders SLC26A2 SLC22A5 GCKR SLC5A1 GCK SLC5A2 SLCO1B1 SLCO1B3 CP SLC6A5 SLC2A9 SLC67A1 SLC26A4 SLC26A3 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH AVPR1B SLC2A10 AVPR2 AVPR1A SLC24A4 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C SLC5A5 NUP42 NUP85 TPR NUP62 SLC35C1 NUP88 NUP43 RAE1 NDC1 SLC20A2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC24A1 NUP37 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 SLC17A5 SLC35A2 SLC35A3 SLC9A6 SLC33A1 AVP SLC9A9 SLC35A1 SLC29A3 SLC6A19 SLC4A1 SLC36A2 SLC27A4 SLC4A4 BSG SLC6A14 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC7A7 SLC5A7 SLC7A9 SLCO2A1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 CSK HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 PTPRC HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 PAG1 HLA-DQB2 HLA-DQB1 LCK P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGFR NGF PRDM4 HDAC1 HDAC2 HDAC3 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC5 HDAC1 HDAC3 HDAC8 HDAC9 HDAC6 HDAC7 MAMLD1 TBL1X RBPJ CREBBP MAML2 NCOR2 MAML1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 SNW1 HDAC11 HDAC4 HDAC2 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 95%1614517 Sulfide oxidation to sulfate TST ETHE1 SLC25A10 TSTD1 SQOR SUOX DENGUE VIRUS-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9918481 Dengue Virus-Host Interactions SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 APOA1 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 PPIL3 PPIL4 TLR4 HNRNPA1 STAT2 LY96 MAPKAP1 PDCD6IP FASN C4BPA C4BPB ATG14 HSP90AB1 CTNNB1 C4B_2 SDC4 SDC2 SDC3 RPTOR MLST8 GPC1 GPC3 UBE2I GPC2 GPC5 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L H2AC25 NEK2 H2AC21 GTF2F1 GTF2F2 IFIH1 HSPA8 UBR4 NRBP1 PEX19 HNRNPA0 CD2BP2 HNRNPUL1 AUP1 PPIL6 ELAVL2 RICTOR H2AC1 CPSF7 SRRM1 VIM HNRNPC RIPK1 RBMX STING1 NFKBIA MAVS CLEC5A HSP90AA1 H2BC18 BECN1 DAXX H2AC19 H2BC26 H2AC14 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 CDC40 H2AC20 DHX9 HSPG2 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 SF3A1 SF3A2 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN WBP11 PRPF6 SNRPG SRSF2 PPIE NFKBIB SRSF3 F2 SNRPE SRSF4 SNRPF SRSF5 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME DATABASE ID RELEASE 95%68881 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism GNG13 GNB2 GNAQ GNB1 KCNJ11 ABCC8 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ACACB ADCY6 ADCY5 GNGT2 RAP1A PRKACG SLC2A1 SLC2A2 PRKACA PRKACB RAPGEF3 FFAR1 RAPGEF4 GNA14 GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 IQGAP1 GNAS GCGR GCG CHRM3 PPP2R1B PPP2R1A ACACA PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 CACNB2 PLCB3 PLCB1 PLCB2 ACSL4 ACSL3 ACLY CACNA1D FASN PPP2R5D STXBP1 INS ADRA2C SYT5 MLX ADRA2A PRKAA2 CACNB3 PRKAG2 PPP2CA STK11 PPP2CB CACNA1A CACNA1E STX1A TKT PRKAB2 KCNG2 AKAP5 GNAI1 GNAI2 AGPAT1 PRKCA CD36 SNAP25 KCNC2 CACNA1C PFKFB1 GLP1R ADIPOQ MLXIPL ADIPOR1 ADIPOR2 TALDO1 KCNB1 KCNS3 VAMP2 AHCYL1 MARCKS GNG10 GNG12 GNG11 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 95%9912633 Antigen processing: Ub, ATP-independent proteasomal degradation PSMB3 PSMA5 PSMA6 PSMB1 PSMA3 PSMA4 PSMA1 PSMA2 PSME2 PSMB10 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB8 PSMB9 PSMB5 PSMB2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 OR10V1 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C HGSNAT DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 95%5083625 Defective GALNT3 causes HFTC MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 MUC2 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC12 MUC17 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 95%5579032 Defective TBXAS1 causes GHDD TBXAS1 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 95%8876493 InlA-mediated entry of Listeria monocytogenes into host cells UBC CBLL1 CTNNB1 RPS27A CDH1 CTNND1 UBA52 SRC UBB ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC39A10 SLC30A1 SLC39A14 SLC39A4 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME DATABASE ID RELEASE 95%9022535 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.2 Hedgehog ligand biogenesis SEL1L IHH VCP DERL2 ERLEC1 OS9 ADAM17 GPC5 P4HB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 HHAT PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 DISP2 PSMC2 SCUBE2 NOTUM SYVN1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 95%9694301 Maturation of replicase proteins ISCU RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.3 RAS signaling downstream of NF1 loss-of-function variants HRAS NF1 SPRED3 SPRED2 SPRED1 NRAS DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 95%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 95%3595177 Defective CHSY1 causes TPBS NCAN CSPG4 CHSY1 BGN DCN BCAN VCAN CSPG5 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes ABCD4 PRSS1 PRSS3 CTRB2 CUBN TCN1 CBLIF CTRB1 AMN LMBRD1 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.3 Acyl chain remodeling of CL HADHB HADHA PLA2G6 PLA2G4A LCLAT1 TAFAZZIN LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 95%3656534 Loss of Function of TGFBR1 in Cancer FKBP1A TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70688 Proline catabolism ALDH4A1 PRODH PRODH2 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 95%417973 Adenosine P1 receptors ADORA2A ADORA2B ADORA3 ADORA1 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME DATABASE ID RELEASE 95%5250955 Toxicity of botulinum toxin type D (botD) VAMP2 SV2C SV2B SV2A VAMP1 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 95%5683826 Surfactant metabolism ADA2 SFTPB SFTA3 SFTPA1 ZDHHC2 SFTPA2 CTSH ADRA2C TTF1 ADRA2A DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 ADORA2B ABCA3 GATA6 ADORA2A CKAP4 SFTPD P2RY2 SLC34A2 SFTPC SLC34A1 CSF2RB CSF2RA ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 95%1247673 Erythrocytes take up oxygen and release carbon dioxide CA4 AQP1 HBA2 SLC4A1 CA1 RHAG CA2 HBB DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 95%5690338 Defective ABCC6 causes PXE ABCC6 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111446 Activation of BIM and translocation to mitochondria MAPK8 BCL2L11 DYNLL1 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 95%444473 Formyl peptide receptors bind formyl peptides and many other ligands MT-RNR2 FPR1 FPR3 APP SAA1 FPR2 HEBP1 ANXA1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 95%8941858 Regulation of RUNX3 expression and activity PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 TGFB1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A SMURF2 EP300 SMURF1 ADRM1 SRC MDM2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 RUNX3 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 CBFB IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 95%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 TRAV29DV5 IGLC3 TRBV7-9 TRBC1 IGLC1 IGLC2 IGKV3D-20 TRAV19 IGKV2-30 IGLV3-19 IGHV2-70 TRAV8-4 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 CD81 HLA-H HLA-B V2-11 HLA-C V3-4 HLA-F V3-3 V2-17 HLA-G HLA-E V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 CD19 V2-8 V1-20 TREM2 V1-9 V5-4 V1-7 V5-1 CDH1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CD40LG ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 C3 VCAM1 SIGLEC9 CXADR ITGB7 B2M HLA-A CD8B SIGLEC5 FCGR1A JAML CD99 ITGB2 COLEC12 ITGB1 CD33 ITGAL ITGA4 LILRA3 IFITM1 CD226 CD1D CD1C CD1B cd21 LAIR1 CD1A SLAMF7 LILRB2 SLAMF6 LILRB3 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD22 CD200 CD300A NCR1 NCR3 CD200R1 OSCAR HCST TYROBP LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 SELL KLRK1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 NCR2 SIGLEC1 SIGLEC8 KIR2DS2 SIGLEC7 SIGLEC6 PVR CD96 CD300LB CD8A TREM1 KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 CD300E KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 KLRD1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 CLEC2B FCGR2B CLEC2D NECTIN2 NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 95%8863678 Neurodegenerative Diseases JUN PRDX2 PRDX1 CDK5 CDC25C CDC25B CDC25A APP YWHAE LMNB1 SOD2 GOLGA2 BCL2L11 CAPNS1 FASLG FOXO3 CAPNS2 CAPN2 CAPN1 CAST CDK5R1 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME%R-HSA-629587.6 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRND CHRNA3 CHRNA4 CHRNG CHRNE PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage UCK1 PUDP TK2 TK1 CDA DCK UPP2 UPP1 TYMP UCKL1 UCK2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 95%202430 Translocation of ZAP-70 to Immunological synapse TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 TRBC1 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 PTPN22 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA CD4 HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCK ZAP70 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM12 ADAM19 SH3PXD2A TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK1 TICAM1 TLR3 RIPK3 CASP8 FADD SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin PRKCA HRAS SOS1 MMP3 HBEGF EGFR NRAS PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.4 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNQ1 CACNG4 KCNE5 AKAP9 CACNG6 CACNG7 CACNA1C CACNA2D2 CACNB2 CACNG8 CACNB1 KCNE1 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 RELA PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MYD88 MEF2C IRAK1 NFKBIA TAB1 TRAF2 MAPKAPK2 TRAF6 UBA52 USP14 BTRC NFKB2 NOD1 ATF1 ECSIT NKIRAS1 NKIRAS2 PELI1 NOD2 MAP3K8 IKBKG USP18 PPP2R1B MAP2K3 UBB PPP2R1A IKBIP RIPK2 MAP2K4 IRAK4 MAPKAPK3 UBC TLR10 TLR5 ALPK1 RPS27A LRRC14 NLRX1 FBXW11 UBE2V1 PELI3 PELI2 NLRC5 AGER TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 TIFA S100A12 MAP2K7 MAP3K1 APP S100B MAPK10 SAA1 TAB3 SKP1 TAB2 HMGB1 FOS TP53 NFKBIB CASP8 ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.9 Cell-Cell communication ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 SPTAN1 POMT2 FYB1 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 ACTN3 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 CASK FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A IQGAP1 JUP RB1 RBBP4 WASL RBBP7 H2AX PIK3CB KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L NCK2 H2BC21 NCK1 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 SIRPG SKAP2 PIK3CA BANP SPTBN1 ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 PIK3R2 H2BC1 PIK3R1 H2AC20 KIRREL3 KIRREL1 KDM1A KIRREL2 MAPK1 MAGI2 CD2AP NPHS1 MAPK3 PTPN11 CD47 HDAC2 SRC ACTN2 SUZ12 SIRPA ARID1A TYROBP PTK2B PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 SIRPB1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 PTPN6 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 FYN SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 PTK2 CTSL NECTIN1 ACTN4 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 95%453276 Regulation of mitotic cell cycle CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d ALG3 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.3 Nitric oxide stimulates guanylate cyclase PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 GUCY1B2 KCNMB4 GUCY1B1 NOS2 NOS3 PDE2A PRKG2 NOS1 GUCY1A2 GUCY1A1 IRAG1 PDE5A NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%8956320 Nucleotide biosynthesis IMPDH1 ADSL IMPDH2 PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS CAD DHODH UMPS ATIC SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702632 sunitinib-resistant FLT3 mutants FLT3 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 95%174437 Removal of the Flap Intermediate from the C-strand ACD PCNA TINF2 TERF1 POLD3 TERF2 POLD4 POLD1 POLD2 FEN1 POT1 TERF2IP RPA1 RPA2 RPA3 WRN DNA2 SIGNALING BY LEPTIN%REACTOME DATABASE ID RELEASE 95%2586552 Signaling by Leptin STAT5A STAT5B JAK2 LEP STAT3 SOCS3 IRS1 PTPN11 IRS2 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 95%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors ZFP36L2 PAIP1 PABPC1 CNOT4 CNOT6 CNOT7 EIF4E EIF4B DICER1 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 AGO2 CNOT8 CNOT9 BTG4 CNOT6L CNOT11 EIF4A2 EIF4A1 EIF4G1 PABPN1L EIF4A3 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%8856825 Cargo recognition for clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 STAM2 STON1 GPS1 STON2 COPS4 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 SGIP1 AP2S1 AGTR1 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 APOB SNAP91 M6PR SYT2 ARRB1 ARRB2 SCARB2 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 TGOLN2 CHRM2 HGS CD4 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 SLC18A3 DAB2 EPS15L1 EPN1 SYT9 GRK3 PICALM VAMP8 IL7R TFRC CFTR SYT1 IGF2R UBA52 STAM UBB UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG BTC EPGN SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 95%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9 CYP2C8 CYP2J2 CYP1A2 CYP1A1 CYP1B1 EPHX2 CYP2C19 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 GCGR ADCY7 ADCY6 GCG ADCY5 PRKACG PRKACA PRKACB GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 95%8963901 Chylomicron remodeling APOA1 APOA4 APOB APOA5 GPIHBP1 APOE APOC2 APOC3 LPL APOA2 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 95%9759811 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 AGO3 AGO4 CDH11 AGO1 AGO2 TNRC6A TNRC6B CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 95%1234174 Cellular response to hypoxia CITED2 CA9 ARNT HIF1AN UBE2D2 UBE2D3 PSMD8 HIF3A PSMD6 LIMD1 PSMD7 ELOB ELOC PSMD2 RBX1 AJUBA PSMD3 EPAS1 CUL2 PSMD1 HIF1A VHL EGLN1 EGLN3 EGLN2 WTIP PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 VEGFA PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC HIGD1A PSMB1 RPS27A EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EPO DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 95%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) FMOD PRELP B4GALT1 OMD KERA ACAN OGN LUM SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702577 semaxanib-resistant FLT3 mutants FLT3 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK CSNK2B CDK5 BMAL1 CSNK2A1 CLOCK DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 95%4720454 Defective ALG9 causes CDG-1l ALG9 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AA1 HSP90AB1 GSD 0%REACTOME DATABASE ID RELEASE 95%3858516 GSD 0 GYG2 GYS2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280215 Cytokine Signaling in Immune system JUN TRIM6 IFNA2 TRIM5 TRIM2 IFNA8 TRIM3 CSH1 XAF1 ARIH1 RELA IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 TRIM45 NPM1 TRIM35 TRIM38 TRIM31 OAS2 TRIM34 IFITM3 IFNA10 IFITM2 IFIT5 IFNA21 IFI35 IFI30 IFIT3 IFNB1 EIF2AK2 IFIT2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR IRF8 IRAK1 IRF6 IRF9 SAMHD1 IL2 IL3 IL6 NOS2 IL17RC IL17RA IL17F IL17A CSF1 CRK GSDMD SOD2 IL18 IL1A KPNB1 IL1B KRAS PELI1 MMP1 FNTA MMP2 DNAJC3 JUNB MAOA HMGB1 CASP8 CRKL VAV1 UBE2N ADAR IRF1 IRF2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IGHG4 IGHG1 MAPK7 SOS2 HSPA1L HSPA2 MAPK8 ATF6 BCL2L11 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 FCER2 CANX UBE2I PTGS2 SUMO1 ALOX5 UBE2D2 UBE2D3 ELOB ELOC RBX1 TRIM25 SDC1 HIF1A GH1 SNAP25 GATA3 LYN INPP5D TNFRSF12A TNFSF12 TNFRSF13C ARF1 TNFRSF11A CD40LG RALA RPLP0 LTBR IL1RN PITPNA LTB BOLA2B IL18RAP IL1R2 CNN2 HNRNPDL IL4 TOLLIP CFL1 STAT4 PTPN20 PTPN23 IL12B IL18BP IFIH1 IL12A IL12RB1 IL13 JAK1 CISH IL1RAPL1 IL12RB2 MAP3K3 PTPN18 HSPA9 IL10 IL37 IKBKG SERPINB2 PTPN12 ACTB ANXA2 SOCS5 PTPN14 GSTO1 RIPK2 PTPN9 CSF2 AIP PTPN7 PTPN5 MSN TALDO1 IL18R1 PTPN2 TYK2 MIF SOD1 MTAP PIK3CD VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 PPIA KPNA2 TP53 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 KPNA7 FKBP5 KPNA4 KPNA5 CSF1R GBP1 KPNA3 MAP3K7 FPR1 SPHK1 MAP2K6 TCP1 MT2A FANCC BCL6 SMAD3 SMAD7 ADAM17 NFKBIA MAVS TAB1 RIGI NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 TRAF2 NUP43 RAE1 KPNA1 ILF2 NDC1 TRAF3 RANBP2 TEC TRAF6 SEC13 BIRC2 NUP155 NUP133 NUP210 BIRC3 NUP153 NUP93 USP14 BECN1 NUP50 NUP35 NUP54 NUP37 NOD1 ITGAM ITGB2 ACTG1 FLT3 NOD2 IRS1 USP18 PPP2R1B IRS2 EIF4E3 PPP2R1A PIK3CB IFIT1 PPM1B PML EIF4E2 FLNB FGF2 TNFRSF1B MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 SOX2 TNIP2 GRB10 HRAS PTPN13 INPPL1 FLT3LG TWIST1 IRF5 EIF4A3 GAB2 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5A SHC1 PPP2R5D PIK3R2 PIK3R1 BST2 NRAS RHOU ALOX15 PTPRJ MAPK1 BIRC5 DHX9 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CDC42 LIFR CD44 PPP2CA PPP2CB CAMK2B HNRNPF CAMK2D SRC CAMK2A CASP1 OPRM1 EIF2AK3 CAMK2G CENPS IFNG UBE2E1 MCL1 CD86 PTK2B UBE2D1 CD80 VEGFA CDK1 IL22 POMC CXCL1 NFKB2 CSK JAK2 HNRNPA2B1 ILF3 IL2RG MMP9 FBXW11 THOC5 ZEB1 HCK SYK LCK SEM1 IRF4 FYN APP F13A1 SKP1 HGF CUL1 CXCL8 CXCL2 STXBP2 CCL11 RAP1B HSPA5 CCL3L3 CCR5 RAF1 PRKACA CTSG CCL5 CCL4 CCL3 CCL2 CA1 CCL19 CCR2 IL1R1 CCR1 CCL22 CCL20 CXCL10 YBX1 PRKRA TARBP2 IFNAR1 P4HB PRTN3 TIMP1 POU2F1 PLCG2 SNRPA1 ANXA1 LBP STX4 STAT5A LAMA5 IL10RA PTAFR FLNA FN1 BRWD1 BLNK GRAP2 HLA-DQA2 BTRC S1PR1 HLA-DQA1 JAK3 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 LCN2 STAT2 MMP3 UBE2L6 HERC5 IL23R IL13RA2 IL13RA1 HLA-H IL4R IL23A CDKN1A FSCN1 HLA-B NDN HLA-C LIF NANOG HLA-F HLA-G IGHE HLA-E OPRD1 OSM BATF CCND1 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 EIF2S2 ATF2 STX3 EIF2S1 IL10RB EIF2S3 CLCF1 EGR1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA STX1A EBI3 IRAK3 MEF2C EIF4E IFNLR1 IL20 IL25 MYC IL26 IL24 IL27 GBP5 IL11 PIM1 IL19 IL16 DUS2 PGGT1B IL17RE GBP2 OSMR GBP4 PSMD8 IL17RB GBP3 PSMD6 HMOX1 IL31 SLA IL17C SLA2 PSMD7 IL11RA SOCS2 IL7 PSMD2 SOCS6 IL7R SH2B3 IFNL2 PSMD3 IFNL1 AKT1 IRF7 IFNL3 PSMD1 PSMB8 NUP214 PRKCD SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 PSMD11 COL1A2 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 RAPGEF1 UBC PSMB1 RPS27A FAAP100 UBE2V1 FAAP24 HSPA8 VAMP2 CUL5 ICAM1 TNFSF13 FAAP20 FANCM ADRM1 UBA7 FANCL MAPK14 FANCA MAPK11 PSMC5 FANCB PSMC6 FANCE PSMC3 FANCG PSMC4 FANCF PSMC1 PSMC2 ABL2 HSPA1A EIF4G1 PAK2 RAG2 RAG1 IL32 CASP3 FURIN UBA3 IL34 IL1RL1 GAB3 IL33 TGFB1 UBE2M FCGR1BP LMNB1 STAT1 VCAM1 IL1RL2 IL36A VIM IL36B IL36G IL36RN IL1F10 TBK1 B2M RELB IRF3 MAP3K14 HLA-A RNF7 TRIM21 GBP6 RORC RORA TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFRSF1A FCGR1A TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 CENPX TNFSF15 CD70 TNFRSF9 EDAR TNFSF6 HSP90AA1 NEDD4 TNFSF4 LTA CBL CD27 TNFSF9 PLCG1 TNFRSF25 TNFSF8 CDKN1B PDE12 OASL OAS1 FNTB OAS3 RNASEL PTPRZ1 CSF3R FOXO1 SOCS3 IL6R H3C8 EIF4A2 EIF4A1 MAP2K1 HSP90B1 H3C15 NCAM1 STAT3 NFKB1 ITGAX PIN1 FASLG TNFRSF18 PRL IFITM1 PIAS1 SNCA IL2RA IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 ABCE1 HAVCR2 IL15RA CD36 PTPN4 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R MUC1 ATF1 NKIRAS1 NKIRAS2 MAP3K8 MAP2K3 IKBIP MAP2K4 IRAK4 MAPKAPK3 BCL2 ALPK1 LRRC14 NLRX1 PELI3 TNF BCL2L1 PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA YES1 S100A12 CEBPD MAP2K7 STAT6 SMARCA4 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 AKT3 TRIM8 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 95%3304351 Signaling by TGF-beta Receptor Complex in Cancer FKBP1A TGFBR2 SMAD2 SMAD4 SMAD3 TGFB1 TGFBR1 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CUBN CBLIF AMN HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5685938.3 HDR through Single Strand Annealing (SSA) ABL1 RAD52 BLM MRE11 BRCA1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 TOP3A RPA1 HUS1 RPA2 RAD50 RAD51 RPA3 RAD17 RAD1 ATM ERCC4 DNA2 ERCC1 RAD9B RHNO1 ATR RAD9A TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins PRKCSH UBA52 GANAB ST6GALNAC3 ST6GALNAC4 MGAT1 GALNT1 MOGS UBB UBC ST3GAL4 CANX RPS27A ST3GAL1 ST3GAL2 UBE2I ST3GAL3 SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 PARP14 PARP8 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle TFRC KIF14 KIDINS220 DSG1 NUDC VANGL1 ARHGAP1 MUC13 PIK3R2 ARHGAP5 PIK3R1 ARHGAP35 PLXND1 PRAG1 TXNL1 ALDH3A2 PKP4 ANKRD26 LEMD3 DEPDC1B RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 BLTP3B TNFAIP1 RND2 PTPN13 NISCH GOLGA3 KTN1 CKAP4 FNBP1 KCTD13 FRS2 SCRIB VANGL2 LRRC1 CAV1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 95%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 NECTIN2 CADM3 CADM1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation PLK3 PIN1 CDK2 PRKAA1 PRKAA2 CDK5R1 AURKB PRKAG1 PRKAG2 PRKAG3 NOC2L STK11 TAF7L CDK5 PRKAB2 TP53INP1 MDM2 PRKAB1 MDM4 TAF4B DYRK2 TBP UBA52 TAF9 TAF1L AURKA TAF15 HIPK1 TAF12 BLM TAF13 MRE11 MAPKAPK5 HIPK2 BRCA1 TAF11 WRN BRIP1 TAF8 KAT5 TAF7 EXO1 CHEK1 TAF6 RBBP8 TAF5 NBN UBB TAF4 TOPBP1 TAF3 SUPT16H ATRIP TAF2 BARD1 TAF1 RFC5 UBC RMI2 RFC3 SSRP1 RFC4 RPS27A RMI1 RFC2 TAF10 TP53RK TOP3A RPA1 CSNK2A1 HUS1 MAPK14 RPA2 MAPK11 CHEK2 CSNK2A2 TAF9B RAD50 CSNK2B RPA3 RAD17 CCNA2 TP53 RAD1 CCNA1 ATM DNA2 NUAK1 RAD9B RHNO1 ATR RAD9A TPX2 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling STEAP4 ATP6V0D1 TFRC HFE ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 TF TCIRG1 STEAP3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 TFR2 ATP6V1B2 MCOLN1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols RXRA CYP51A1 NCOA2 CYP19A1 POMC ARNT2 CYP7B1 CYP11A1 NCOA1 CYP7A1 CYP1B1 CYP27A1 CYP39A1 CYP11B2 CYP11B1 ARNT CYP21A2 AHRR FDXR CYP8B1 NR1H4 CYP46A1 CYP4V2 FDX1 FDX2 AHR RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHPN1 TAX1BP3 RHPN2 RTKN RHOC LIN7B ROPN1 RHOA RHOB DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 95%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764790.1 Positive Regulation of CDH1 Gene Transcription KLF4 SP1 TFAP2A ZEB2 FOXP2 FOXJ2 STRAP KLF9 ARID1A FOXA2 RB1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 95%448424 Interleukin-17 signaling RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 IL25 TAB1 IL17RE IL17RB IL17C IL17RC IL17RA IL17F IL17A MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 95%192105 Synthesis of bile acids and bile salts RXRA OSBP NCOA2 AMACR SLC27A2 SLC27A5 CYP7B1 OSBPL9 AKR1D1 OSBPL7 OSBPL6 NCOA1 CYP7A1 OSBPL3 OSBPL2 CYP27A1 ACOT8 BAAT CYP39A1 ACOX2 OSBPL1A ABCB11 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 HSD17B4 NR1H4 CH25H CYP46A1 HSD3B7 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 95%2467813 Separation of Sister Chromatids NUP107 CDCA5 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 ESPL1 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A PTTG1 KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH PSMD8 CENPI PSMD6 TAOK1 CENPK PSMD7 CENPL XPO1 CENPM PSMD2 CENPN B9D2 PSMD3 CENPO CENPP PSMD1 CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PSMA5 PLK1 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CLIP1 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 95%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 95%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 95%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 95%2428928 IRS-related events triggered by IGF1R SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 95%8874081 MET activates PTK2 signaling ITGA3 LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 SRC LAMB1 LAMC2 LAMC1 ITGA2 MET HGF PTK2 ITGB1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 ATR RAD9A GASTRULATION%REACTOME DATABASE ID RELEASE 95%9758941 Gastrulation SOX17 TBX6 POU3F1 YAP1 POU5F1 PAX6 MAMLD1 FOXC2 CXCR4 FOXC1 IHH PAX2 MESP2 DLL3 HES7 MSGN1 RIPPLY2 SMAD2 SMAD4 GSC SMAD3 MIXL1 PAX3 ZNF521 FOXA2 FGFR1 MAML2 DLX5 MAML1 FGF2 FGF4 MYB EP300 SOX2 GATA6 TBXT EOMES MAML3 NOTCH1 BMP4 TCF7L2 TCF7L1 NANOG LEF1 TCF7 ZIC1 CTNNB1 RBPJ TFAP2A TFAP2B CDH1 SNW1 TFAP2C EPHA4 TEAD2 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 TBPL2 GATA4 MSX1 PSMA5 OSR1 PSMA6 PSMA3 ZIC2 PSMA4 PSMA1 TRIM33 PSMA2 PAX8 PAX7 PSMD12 PSMD11 NOG PSMD14 NOTO FOXH1 PSMD13 FOXF1 WNT3A PSMA7 PSMB6 SHH ZEB2 PSMB7 SNAI1 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP PSMB1 KAT2B KAT2A LFNG ADRM1 LHX1 PSMC5 PSMC6 SEM1 DLL1 PSMC3 PSMC4 PSMC1 FOXA1 PSMC2 FGF8 SOX1 GBX2 OTX2 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 95%2132295 MHC class II antigen presentation CLTC CLTA AP2A1 AP2A2 KIF5C AP2M1 KIFAP3 KLC1 KLC4 KLC3 KLC2 IFI30 SAR1B KIF3A KIF3B AP2S1 AP1G1 AP1S2 KIF3C SEC23A AP1S1 KIF5B AP1S3 KIF5A AP1M2 KIF4B AP1M1 AP2B1 HLA-DOA AP1B1 KIF4A HLA-DOB LAG3 KIF11 CTSO CTSF CTSE HLA-DMA HLA-DMB KIF15 RILP CD74 SEC24B SEC24A KIF22 SEC13 HLA-DQA2 SEC24D HLA-DQA1 HLA-DPA1 HLA-DRB5 SEC24C HLA-DRB4 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 DYNC1LI1 CAPZB DYNC1LI2 KIF26A CTSD KIF23 KIF20A KIF18A DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A ACTR1B CTSH CTSC KIF2C KIF2B CAPZA3 DNM1 CAPZA2 DNM2 DYNC1I2 LGMN ACTR10 SEC31A CANX DYNC1I1 DYNC1H1 CTSS CENPE DNM3 SPTBN2 ACTR1A ARF1 OSBPL1A RAB7A SH3GL2 DCTN2 CAPZA1 DCTN3 CTSA RACGAP1 CTSB CTSV CTSL CTSK ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A8 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 PTEN AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.5 Synthesis of IP3 and IP4 in the cytosol PLCB4 INPP5D PLCG1 PLD4 OCRL INPP5B SYNJ1 PLCZ1 INPP5J PLCE1 ITPK1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PTEN PLCD1 INPPL1 PLCG2 PLCB3 PLCB1 PLCB2 CALM1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC29A1 SLC28A1 SLC29A3 SLC29A2 SLC25A5 SLC28A3 SLC25A4 SLC25A6 ARL2 ARL2BP SLC29A4 SLC28A2 HYPUSINYLATION%REACTOME DATABASE ID RELEASE 95%204626 Hypusinylation DOHH EIF5A DHPS EIF5A2 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 95%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADHA ECHS1 ACADS HADH CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 95%110331 Cleavage of the damaged purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 95%5579013 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking CLTB WNT5A ARPC1A RHOBTB3 KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 AVPR2 PLA2G4A CTTN RAB9A RAB9B KIF5B KIF5A ARF4 APOB YWHAE M6PR VPS45 EXOC8 EXOC7 YWHAQ YWHAG EXOC4 YWHAH EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 USO1 GBF1 RAB3IP TGOLN2 SPTAN1 RAB11A RAB1A RAB1B HGS RAB5A MIA3 GORASP1 CHMP4C CHMP4B CHMP4A ITSN1 COPS7B RAC1 CHMP2B COPS7A CHMP2A COPS3 COPS6 COPS5 COPS8 CHMP3 CHMP6 CHMP7 PLA2G6 DCTN6 DCTN5 DCTN1 GJC1 DCTN4 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 MAN2A1 GJA9 CAPZA3 GJA8 DNM1 GJD2 CAPZA2 GJB2 GJD4 ACTR10 ARF3 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 CHM TMED2 CD59 DNM3 CD55 PIP5K1C CFTR RAB3A SYT1 ARF1 STAM RALA RAB4A SYNJ2 SYNJ1 VAMP7 CAPZA1 NEDD8 GOSR2 GRK2 LRP2 ARFGAP1 PREB KDELR3 RAB14 GNS STAM2 CLINT1 ADRB2 PAFAH1B2 ITSN2 GJA1 ARRB1 ARRB2 STX5 RAB31 SEC13 RAB5B RAB5C RAB6A TXNDC5 TRAPPC1 DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A CPD TRAPPC13 SNAP29 TBC1D10A TBC1D10B GABARAPL2 SYTL1 DYNC1LI1 CAPZB GAPVD1 DYNC1LI2 RAB32 RAB35 ZW10 TBC1D24 TBC1D25 RAB38 AKT2 DENND6B RIN3 RAB10 DENND6A RIN1 RIN2 GABARAP RAB18 TBC1D13 DVL2 TBC1D14 TBC1D17 TBC1D15 TBC1D16 ANKRD27 TBC1D10C DENND4B CCZ1B DENND4A DENND4C KIF18A HPS1 SBF1 SCFD1 CCZ1 HPS4 SPTBN1 SBF2 RAB39B TRAPPC8 MON1A MON1B DENND1C DENND1B SURF4 GDI1 DENND1A RAB8B DENND2D DENND2C DYNLL1 DENND2B DENND2A INS RAB3IL1 RAB33A DYNLL2 CTSZ RHOQ TBC1D2 GDI2 RABEP1 TBC1D3 KIF2A TBC1D7 RAB7B RABGAP1 DENND3 TRIP10 RAB21 CTSC KIF2C KIF2B ALS2CL CHML TJP1 RAB11B SLC18A3 PAFAH1B1 RAB12 RAB13 DYNC1I2 PIK3C2A DYNC1I1 SYT9 GRIA1 DYNC1H1 GRK3 PICALM CENPE TFG ALS2 AGPAT3 CALM1 COPB1 IGF2R GOLGB1 HIP1 AP3B1 GOLGA4 ANK1 MYO5A OPTN RAB27A RAB8A APP USP6NL CLTC KIF28P SCOC SYS1 CLTA KDELR1 GOLIM4 AP2A1 GCC2 GCC1 RAB43 STXBP3 AP2A2 RAB41 GOLGA5 KIF5C LDLRAP1 GOLGA1 AP2M1 ARFIP2 KIF21A KIF21B KIFAP3 COG8 COG7 COG6 COG5 COG4 COG3 RAB27B COG2 COG1 RINT1 RAB30 RAB36 TF KIF16B SAR1B KDELR2 KIF20B COPB2 COPA TMED10 ARL1 AP2S1 KIF3B AGTR1 MAN2A2 VTI1A LDLR SERPINA1 KIF3C RAB6B RAB39A KIF18B KIF4B AP2B1 ALPP KIF4A COPE KIF12 KIF11 USE1 BICD1 RABEPK BICD2 KIF15 KIF19 MAN1A2 F5 KIF13B F8 TMED3 KIF1C KIF1B MAN1A1 KIF1A TMED7 TMED9 NAA30 KIF25 COPZ2 KIF22 STX4 KIF6 BET1L KIF27 COPZ1 SH3KBP1 SLC2A8 RAB33B KIF9 KIFC2 KIFC1 CD3G NAA35 CD3D NAA38 VAMP4 PAFAH1B3 ARF5 NAPA NAPB NBAS CHRM2 TMF1 STX16 STX18 GOSR1 GOLGA2 NAPG STX10 CYTH3 ARFRP1 CYTH2 CYTH4 CUX1 VPS51 CD4 VPS53 VPS52 MAN1C1 BNIP1 STX6 VPS54 CYTH1 RIC1 MYO1C GALNT2 ARCN1 RGP1 KIF26A KIF26B TRIP11 RAB3GAP2 COPG2 COPG1 RAB3GAP1 MYH9 FZD4 HBEGF ULK1 COL7A1 DNM2 PRKAA2 EPS15L1 SEC31A EPN1 PRKAG1 LNPEP PRKAG2 PRKAG3 SPTB PRKAB2 TSC2 TSC1 PRKAB1 YWHAB VAMP8 ANK2 ANK3 SPTBN4 SPTBN5 IL7R AKT1 SPTBN2 TFRC SFN YWHAZ SNAP23 UBA52 ACTR1A SPTA1 CSNK1D VPS36 VPS25 OCRL SNF8 UBB UBC VAMP3 RPS27A RAB7A HSPA8 DCTN2 VAMP2 DCTN3 LMAN1 RACGAP1 YKT6 BIN1 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 SNAPIN STON1 GPS1 STON2 AP3S1 SNX18 TPD52 RALGAPA2 COPS4 RALGAPB AP4S1 COPS2 MYO6 KIAA0319 TOR1A KIF3A TOR1B TRAPPC4 AAK1 AP4M1 AP1G2 SH3D19 SGIP1 SEC22B DNAJC6 AP1G1 FCHO1 AP1S2 SEC23A FCHO2 AP1S1 UBQLN1 AP1S3 UBQLN2 HIP1R AP1M2 TPD52L1 AP1M1 NECAP2 NECAP1 AP1B1 SYT11 AGFG1 SNX2 FNBP1L SNX9 SNX5 TBC1D8B PUM1 SNAP91 C2CD5 AP4E1 GAK SYT2 SORT1 FNBP1 YIPF6 SCARB2 AMPH SEC24B PACSIN2 PACSIN3 SEC24A PACSIN1 ASPSCR1 AP4B1 SYT8 ACBD3 EPN2 TBC1D1 MAP1LC3B TBC1D4 DNASE2 REPS2 CLVS2 EGF ANKRD28 CBL REPS1 EGFR CLVS1 DTNBP1 PPP6C PPP6R3 SEC24D ARF6 SEC24C WASL GALNT1 ARFGAP3 ARFGAP2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A TRAPPC2L VPS37B LMAN1L KIF23 TBC1D20 CHMP5 VPS4B LMAN2L VPS4A SEC31B MVB12B TRAPPC2 MVB12A SEC16B UBAP1 TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 KIF20A TMEM115 CNIH2 CNIH3 MCFD2 MIA2 PPP6R1 TRAPPC6A FTH1 TRAPPC6B SEC22A SEC22C FTL STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 NSF PLIN3 GGA2 GGA1 GGA3 AREG SH3GL3 EPS15 SH3GL2 SH3GL1 AVP SLC2A4 TACR1 TGFA EREG BTC EPGN AKT3 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 95%9914274 3-methylglutaconic aciduria AUH DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 95%3359478 Defective MUT causes MMAM MMAA MMUT SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways YWHAH YWHAZ SFN SP1 SMAD4 SMAD3 EP300 UBE2I YWHAB PSMC6 YWHAE PDPK1 YWHAQ CAV1 YWHAG FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190377 FGFR2b ligand binding and activation FGFBP3 FGFBP1 FGFBP2 FGF1 FGF10 FGF2 FGF3 FGF22 FGF7 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 95%5654743 Signaling by FGFR4 SOS1 CBL PIK3R1 NRAS PLCG1 UBA52 FGF20 MAPK1 FGF23 KLB MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 FGF19 PPP2CA FGF18 PPP2CB UBC FGFR4 FGF1 FGF2 FRS3 RPS27A FGF4 FGF6 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane MTMR2 PIK3C2A MTMR9 MTMR4 MTM1 PIK3R4 FIG4 MTMR7 PIKFYVE PIK3C3 VAC14 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 95%5624138 Trafficking of myristoylated proteins to the cilium UNC119B ARL3 CYS1 NPHP3 RP2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%5357769 Caspase activation via extrinsic apoptotic signalling pathway TRAF2 TNFSF10 TNFRSF10B UNC5A TNFRSF10A DAPK1 UNC5B DAPK2 DAPK3 FADD CD14 MAGED1 APPL1 FAS FASLG TLR4 RIPK1 TICAM2 DCC TICAM1 LY96 TRADD CASP8 CASP9 CASP3 CLEARANCE OF DOPAMINE%REACTOME%R-HSA-379401.6 Clearance of dopamine MAOA TOMT SLC6A3 COMT REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 95%5357905 Regulation of TNFR1 signaling XIAP RACK1 STUB1 TRAF1 UBE2L3 TRAF2 UBE2D1 ULK1 MAPKAPK2 FADD USP4 UBA52 BIRC2 USP2 BIRC3 MIB2 CYLD SPPL2B SPPL2A CLIP3 RBCK1 OTUD7B CHUK IKBKG UBB IKBKB RIPK1 UBC RPS27A USP21 SHARPIN TNF TBK1 OTULIN OPTN TAX1BP1 UBE2D2 UBE2D3 TRADD TNFAIP3 RNF31 CASP8 SPATA2 IKBKE TNFRSF1A OTUD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME DATABASE ID RELEASE 95%174143 APC C-mediated degradation of cell cycle proteins CDK2 AURKB BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC14A CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164939 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 95%9627069 Regulation of the apoptosome activity XIAP MAPK1 CARD8 CYCS AVEN APIP UACA CASP9 MAPK3 APAF1 DIABLO SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF TGFA AREG EGF EGFR EREG BTC EPGN ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 95%2473224 Antagonism of Activin by Follistatin FST FSTL3 INHBB INHBA SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 95%9793242 SUMOylation of nuclear envelope proteins RANGAP1 UBE2I SUMO1 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOA1 APOE APOC2 APOC3 LIPG ALB CETP ABCG1 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9026357 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A ATP6V1H SESN1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB SESN2 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SEC13 SZT2 SAMTOR SEH1L NPRL2 NPRL3 TCIRG1 WDR59 FLCN MIOS ITFG2 DEPDC5 KPTN WDR24 SH3BP4 FNIP1 ATP6V1E1 FNIP2 KICS2 ATP6V1E2 CASTOR1 CASTOR2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6V1B2 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.3 SHC-mediated cascade:FGFR3 HRAS FGF18 SOS1 FGF1 FGF2 FGF23 FGF4 FGF9 NRAS FGF20 FGF16 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G NFIX POLR3H POLR2K SSB BDP1 POLR2L NFIA POLR3K NFIB NFIC SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ZNF143 BRF2 POU2F1 GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3359454 Defective TCN2 causes TCN2 deficiency TCN2 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 95%68877 Mitotic Prometaphase CEP41 TUBGCP4 CEP43 TUBA1A PRKACA SMC4 SMC2 YWHAE TUBB4B TUBB4A NUP107 EML4 CDCA5 NUP160 NCAPG YWHAG NCAPH NUP85 NUP43 HSP90AA1 NCAPD2 RANBP2 SEC13 NUP133 NUMA1 FIRRM NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 CPAP KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 PRKAR2B PDS5B DSN1 SMC1A SMC3 PDS5A WAPL RCC2 STAG1 NDC80 ZWINT STAG2 RAD21 KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CCP110 CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 CENPS PLK1 CCNB1 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 TUBG1 HAUS2 HAUS1 MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 CSNK2A1 DCTN3 HAUS8 HAUS7 CSNK2A2 CEP70 CEP72 CEP192 TUBA4A PCNT CSNK2B CEP76 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 NEK7 MZT1 NEDD1 ALMS1 TUBGCP5 CLIP1 TUBGCP6 TUBGCP3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 95%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP GTF3C5 GTF3C6 BRF1 TBP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F POLR3G POLR3H POLR2K BDP1 POLR2L POLR3K GTF3A POLR1C POLR1D GTF3C1 GTF3C2 GTF3C3 GTF3C4 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559586 DNA Damage Telomere Stress Induced Senescence H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 CDKN1A POT1 TERF2IP H2AC20 HMGA2 H1-1 H1-0 H1-3 CDK2 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A RB1 CDKN1B HMGA1 MRE11 KAT5 CCNE2 CCNE1 H2AX NBN H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 CCNA2 TP53 CCNA1 H2BC11 ATM HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 95%2160916 Hyaluronan degradation GUSB CD44 SLC17A5 HMMR CEMIP STAB2 SLC9A1 LYVE1 HYAL2 HEXB HEXA CHP1 SPAM1 HYAL1 HYAL3 HYAL4 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.2 Defective F8 secretion F8 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-HSA-1655829.4 Regulation of cholesterol biosynthesis by SREBP (SREBF) GGPS1 RXRA SCD CYP51A1 FASN LSS SREBF2 SQLE MTF1 DHCR7 ACACB GPAM NFYA NFYB NFYC TBL1X NCOA1 SAR1B SEC23A TBL1XR1 MBTPS1 SCAP MBTPS2 SEC24B SEC24A NCOA2 NCOA6 RAN INSIG2 SMARCD3 INSIG1 SEC24D MVD SEC24C CARM1 KPNB1 HELZ2 CREBBP CHD9 SP1 ACACA MED1 TGS1 IDI1 ELOVL6 MVK TM7SF2 PMVK SC5D FDFT1 FDPS HMGCS1 PPARA DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 95%9920588 Dengue virus activates modulates innate and adaptive immune responses C4A CLEC5A C4BPA C4BPB CDC73 EXOC1 HSP90AA1 SKIC8 DDX3X HSP90AB1 CTR9 CLU RTF1 VTN APOA1 LEO1 PAF1 IFIH1 C4B_2 CGAS RBM10 STAT2 STING1 MAVS UBR4 C1QA C1S MBL2 TRIM25 IKBKE PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 95%167290 Pausing and recovery of HIV elongation POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 CCNT2 ELOB ELOC REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 95%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 PAX4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome AIM2 CASP1 PYCARD PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%418360 Platelet calcium homeostasis P2RX3 P2RX2 P2RX1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI TRPC7 TRPC6 ATP2B4 ATP2B3 TRPC3 ATP2B2 ATP2B1 SLC8A3 P2RX7 P2RX6 CALM1 P2RX5 P2RX4 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 95%8877627 Vitamin E transport TTPA RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%73762 RNA Polymerase I Transcription Initiation CCNH TBP TAF1D TAF1B TAF1C POLR2E POLR2F TAF1A POLR2H HDAC1 POLR2K POLR2L MTA2 GTF2H1 ERCC6 GTF2H2 GTF2H3 RBBP4 MTA1 GTF2H4 MBD3 GTF2H5 MTA3 CDK7 TTF1 RBBP7 ERCC3 RRN3 ERCC2 MNAT1 EHMT2 GATAD2B GATAD2A CHD3 KAT2B KAT2A HDAC2 UBTF POLR1A POLR1B CHD4 POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 95%2980736 Peptide hormone metabolism GNG13 CGA GNB1 TCF7L2 GNB3 KIF5C INS CTSZ SLC30A8 PCSK1 GNAT3 GPR119 SLC30A5 PAX6 CPB2 ISL1 GIP CTSG FSHB DPP4 CTNNB1 INHBB IGF1 SPCS3 INHBA SPCS2 SPCS1 INHA FFAR1 INHBC SEC11A INHBE SEC11C ACHE LHB ACE2 STX1A KIF5B KIF5A P4HB BCHE PCSK2 ERO1B CGB8 CPA3 MME CDX2 ENPEP AGT LEP EXOC8 CPB1 FFAR4 EXOC7 CLTRN ACE UCN CES1 CPE GATA4 MBOAT4 REN PLA2G7 CRHR2 GH1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GRP TSHB CMA1 GCG POMC ATP6AP2 KLF4 MYO5A RAB27A VAMP2 MYRIP CTSD ANPEP GZMH PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8964208 Phenylalanine metabolism PAH ASRGL1 KYAT1 QDPR IL4I1 PCBD1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 95%8941855 RUNX3 regulates CDKN1A transcription RUNX3 SMAD4 SMAD3 TP53 CDKN1A ZFHX3 TGFB1 RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.3 Recycling pathway of L1 CLTC RPS6KA1 CLTA AP2A1 AP2A2 AP2M1 RDX MAPK1 NUMB DNM1 DNM2 MSN AP2S1 SH3GL2 RPS6KA4 KIF4B AP2B1 KIF4A SHTN1 DNM3 RPS6KA6 EZR RPS6KA3 RPS6KA5 L1CAM DPYSL2 RPS6KA2 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 95%9764274 Regulation of Expression and Function of Type I Classical Cadherins ZNF217 ARHGAP32 FURIN PCSK6 STRAP TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 TCF3 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 KMT5A FOXA2 TGIF2 EED JUP RB1 RBBP4 POMT2 RBBP7 POMT1 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 RACK1 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 RPN2 H2BC1 PRKCSH HDAC1 RPN1 H2AC20 KDM1A MAPK1 GANAB CTNNB1 OST4 DNM2 MOGS MAPK3 DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A TFAP2A AGO3 AGO4 CDH1 MYC CTSS AGO1 AGO2 HDAC2 SRC TNRC6A TNRC6B PSMD8 ANK3 PSMD6 SUZ12 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 ARID1A PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 CSNK2A3 EZH2 PCSK7 PSMA7 PSMB6 MPHOSPH8 ZEB2 PSMB7 SNAI1 PSMB4 CTBP2 CTBP1 PSMB5 UBB PSMB2 PSMB3 UBC SP1 VCL PSMB1 MTBP RPS27A EPS15 ADRM1 WT1 CSNK2A1 ZEB1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 SMARCA4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB CTSL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins HERC2 XRCC4 PARP1 CDKN2A RAD52 MDC1 SP100 BMI1 SUMO3 SUMO2 RING1 PIAS1 UBE2I SUMO1 RNF2 CBX8 PHC2 PHC1 NUP205 POM121 CBX4 NUP107 PCGF2 NUP188 CBX2 PHC3 AAAS NUP214 NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 PIAS4 NSMCE3 NSMCE2 NUP88 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 CETN2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 BLM BRCA1 NUP37 WRN PML RPA1 SMC1A XPC SMC3 STAG1 STAG2 RAD21 TDG SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.1 SLC-mediated transport of organic anions SLCO4A1 SLCO2B1 SLC16A2 SLCO1B1 SLCO1B3 SLC25A11 SLC25A1 SLC25A10 SLC13A2 SLC22A12 SLC13A3 SLCO1C1 SLC5A12 SLC16A7 SLCO1A2 SLC16A8 EMB SLC13A5 SLC16A3 SLC17A5 SLC16A1 AVP SLC22A7 SLC22A6 SLC22A8 SLC10A6 SLC5A8 SLCO4C1 BSG SLC44A5 SLC44A3 SLC22A11 SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLCO2A1 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME DATABASE ID RELEASE 95%5579005 Defective CYP4F22 causes ARCI5 CYP4F22 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 95%9932298 Degradation of CRY and PER proteins FBXL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 CRY2 CRY1 ADRM1 FBXL21P PSMC5 PSMC6 PER2 SEM1 PSMC3 PER1 PSMC4 PER3 PSMC1 PSMC2 SKP1 CUL1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 95%9924644 Developmental Lineages of the Mammary Gland PRL FGF10 TGFA AREG EGF FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 SGF29 NCOA6 KANSL1 PHF20L1 KANSL2 SETD1B KANSL3 SETD1A RBBP5 KMT2D PHF20 BOD1L1 ASH2L MBIP TASP1 KMT2C DR1 KMT2B BOD1 KAT2B KAT2A YEATS2 AKAP8L MEN1 TADA3 PAGR1 KAT8 OGT HCFC2 WDR82 PAXIP1 KDM6A DPY30 KAT14 MCRS1 WDR5 KMT2A PSIP1 ZZZ3 HCFC1 TADA2A DEFECTIVE GALM CAUSES GALAC4%REACTOME DATABASE ID RELEASE 95%9931929 Defective GALM causes GALAC4 GALM CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 95%5218900 CASP8 activity is inhibited RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME DATABASE ID RELEASE 95%9672395 Defective F8 binding to the cell membrane F8 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%209952 Peptide hormone biosynthesis PCSK1 CGA LHB CGB8 FSHB INHBB TSHB INHBA INHA INHBC INHBE POMC RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 95%9649913 RAS GTPase cycle mutants HRAS NRAS KRAS MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development RPS6KA1 EDNRB ASAH1 DICER1 TRPM1 PAX3 YWHAE SNAI2 TNFSF11 YWHAG EDN1 CSF1 YWHAH EDN3 PXN SMARCD1 SMARCD2 SMARCD3 RARS1 LARS1 AIMP1 AIMP2 QARS1 MC1R MARS1 SMARCE1 MC4R DARS1 EEF1E1 LIG1 MC3R KARS1 GMPR IARS1 EP300 MC5R SOX2 AKT2 ATP6V1E1 SOX9 ATP6V1G1 ATP6V0B ATP6V0E1 KIT DIAPH1 ATP6V1B2 ATP6V0D1 ATP6V0C ATP6V1A SERPINE1 TCF7L2 CDKN1A TCF7L1 HDAC1 CDKN2A LEF1 TCF7 CDC25B ATP6V1H ZIC1 FOXD3 MAPK1 TBX2 HINT1 TFE3 CCND1 MITF ITGA2 SIN3A TFEC ALX3 CDK2 TBX3 CTNNB1 MET ATP6V1C1 GPR143 MAPK3 EPRS1 TNRC6C MOV10 ID1 TFAP2A AGO3 STT3B AGO4 CDH1 UBE2I AGO1 AGO2 DPF1 SUMO1 TNRC6A TNRC6B DPF2 YWHAB DPF3 XPO1 SS18L1 ARID1A GSK3B ARID1B YWHAZ PPARGC1A PLK1 SS18 SMARCB1 CCNB1 POMC WNT3A SOX10 SMARCC1 BRCA1 SMARCC2 MARK3 ACTB ACTL6A CREBBP GXYLT2 CDH2 BCL2 POU3F2 SYTL2 PMEL TFEB TERT MYO5A RAB27A TYR EDIL3 MYRIP MAPK14 CEACAM1 ZEB1 BCL7A DCT BCL7C IRF4 SMARCA2 BCL7B PXDN SMARCA4 BIRC7 BCL2A1 TYRP1 SIRT1 MLANA USF1 MLPH MCM5 MCM2 AKT3 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK2 PANK3 PANK1 DCAKD DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex FRAT2 PPP2R5B PPP2R5A PPP2R5D PPP2R5C TCF7L2 TCF7L1 HDAC1 LEF1 TLE4 TCF7 TLE2 TLE1 CTNNB1 PPP2CA PPP2CB PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 AMER1 GSK3B CSNK1A1 AXIN1 TLE5 APC PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ZRANB1 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CTBP2 CTBP1 PSMB5 PPP2R1B UBB PPP2R1A PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TLE3 SKP1 CUL1 FRAT1 PPP2R5E MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%8875656 MET receptor recycling CRK ARF6 RAB4A RAB4B MET GAB1 GGA3 HGF CRKL IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%112399 IRS-mediated signalling SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 FGF22 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 95%162589 Reverse Transcription of HIV RNA PPIA PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 95%9754189 Primitive streak formation SMAD2 SMAD4 GSC SMAD3 MIXL1 TRIM33 BMP4 POU5F1 SOX2 TBXT NANOG LEF1 TCF7 EOMES FOXH1 CTNNB1 TBPL2 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%176034 Interactions of Tat with host cellular proteins CDK9 CCNT1 DISSOLUTION OF FIBRIN CLOT%REACTOME%R-HSA-75205.5 Dissolution of Fibrin Clot PLAT SERPINE1 SERPINB8 SERPINB6 S100A10 PLAU PLAUR SERPINE2 SERPINF2 SERPINB2 PLG ANXA2 HRG PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 95%1912420 Pre-NOTCH Processing in Golgi ST3GAL4 TMED2 SEL1L RFNG MFNG B4GALT1 FURIN LFNG ST3GAL6 ST3GAL3 ATP2A3 RAB6A ATP2A2 ATP2A1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo YAP1 TJP2 WWC1 STK4 SAV1 WWTR1 STK3 MOB1B YWHAB LATS1 MOB1A LATS2 DVL2 AMOTL2 AMOTL1 YWHAE TJP1 NPHP4 CASP3 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells TGFA AREG EGF PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 95%8849470 PTK6 Regulates Cell Cycle CCND1 PTK6 CDK2 CDK4 CCNE1 CDKN1B CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) IDH3B CS ISCA2 IDH3A MDH2 ISCA1 ACO2 ACAT1 LYRM4 SUCLG2 KGD4 SUCLG1 CSKMT SDHC TRAP1 SDHD SDHA SDHB OGDH FXN NNT SUCLA2 SDHAF2 SDHAF3 SDHAF1 SDHAF4 FH IDH2 SIRT3 DLST IDH3G DLD INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 95%9705462 Inactivation of CSF3 (G-CSF) signaling STAT5A STAT5B UBE2D1 LYN STAT3 UBA52 JAK2 JAK1 STAT1 SOCS1 UBB CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins AQP1 GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 RAB11A PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 AVP GNG4 GNG7 GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A RAB11FIP2 MYO5B GNG10 AQP4 AQP2 GNG12 AQP3 GNG11 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME%R-HSA-451306.4 Ionotropic activity of kainate receptors GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 95%177504 Retrograde neurotrophin signalling NTRK1 CLTC AP2S1 CLTA AP2A1 AP2A2 SH3GL2 NGF AP2B1 AP2M1 DNAL4 DNM3 DNM1 DNM2 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 95%1442490 Collagen degradation MMP15 COL18A1 COL17A1 MMP19 COL15A1 COL16A1 TMPRSS6 COL13A1 COL14A1 FURIN COL12A1 COL19A1 ELANE COL26A1 COL25A1 COL23A1 ADAM10 ADAM9 PRSS2 MMP8 MMP9 COL9A1 MMP1 COL9A3 MMP2 COL9A2 ADAM17 PHYKPL CTSD MMP3 CTSB MMP20 CTSL MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation IKBKB TASL CHUK IRF5 SLC15A4 IKBKG TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 95%159227 Transport of the SLBP independent Mature mRNA NUP85 TPR NUP62 NXF1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 ALYREF NUP35 NUP54 NUP37 NCBP1 NCBP2 EIF4E NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 95%9634597 GPER1 signaling GNG13 ITGA5 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 SRC GNG8 PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNAI3 GNAI1 GNAI2 GNG10 ITGB1 GNG12 GPER1 GNG11 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation TRAF2 RELA NFKB1 TRAF6 NFKB2 CHUK IFIH1 TRIM4 NKIRAS1 NKIRAS2 IKBKG IKBKB NFKBIA AGER MAVS RNF135 S100A12 MAP3K1 RIGI APP S100B SAA1 HMGB1 NFKBIB TRIM25 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 95%4085001 Sialic acid metabolism ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE NPL NEU2 NEU3 NEU4 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 CTSA ST6GALNAC1 CMAS SLC35A1 ST6GALNAC2 ST8SIA1 ST8SIA2 NANP ST8SIA3 NANS GLB1 ST6GAL1 ST6GAL2 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL PGM1 GYG1 PYGM PHKG1 PHKG2 GYG2 AKR1E2 AGL PHKA1 PHKB PHKA2 GAA CALM1 PYGB METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins ACE2 CMA1 CTSZ CTSD CPB2 CTSG CPA3 MME ANPEP ENPEP AGT CPB1 GZMH ATP6AP2 ACE CES1 REN REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry ACE2 VCP TMPRSS2 CTSL HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.3 HSF1-dependent transactivation CREBBP RPTOR MLST8 HSP90AA1 HSPA8 EP300 CAMK2B CAMK2D HSPB8 HSP90AB1 CAMK2A MTOR DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A CRYAB AKT1S1 FKBP4 HSPA1B CAMK2G INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 95%1266695 Interleukin-7 signaling STAT5A STAT5B STAT3 PIK3R2 PIK3R1 BRWD1 JAK3 JAK1 CISH TSLP IL2RG SOCS1 IRS1 IRS2 CRLF2 H3C8 SMARCA4 SOCS2 IL7 IL7R RAG2 RAG1 HGF PIK3R3 H3C15 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.6 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP85 TPR NUP62 NUP88 GCKR NUP43 GCK RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AA1 FURIN HSPA8 CSNK2A1 HSP90AB1 CSNK2A2 PPP1CA CSNK2B SPCS3 XPO1 SPCS2 SPCS1 SEC11A KPNB1 SEC11C PPP1CB PPP1CC SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RXRA CYCS HDAC3 NR1D1 TBL1X NCOA1 ESRRA ATF2 POLRMT POLG2 NCOR1 MEF2C TBL1XR1 TWNK SSBP1 HCFC1 CALM1 PPARGC1A NCOA2 PPARGC1B NCOA6 SMARCD3 NRF1 GLUD1 GLUD2 SOD2 CRTC2 SIRT4 CARM1 CRTC3 CRTC1 HELZ2 CREBBP CHD9 ALAS1 MTERF1 GABPA MED1 SIRT5 TGS1 PPRC1 MEF2D PERM1 CAMK4 IDH2 SIRT3 ATP5F1B TFAM TFB2M TFB1M ACSS2 PPARA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 95%201556 Signaling by ALK STAT3 PIK3R2 PIK3R1 HDAC1 PLCG1 HDAC3 JAK3 SIN3A ALKAL2 ALKAL1 PRDM1 CD274 IL2RG PTPRZ1 IRS1 DNMT1 PIK3CB PTN MYCN MDK EP300 MYC PTPN6 HDAC2 ALK FRS2 HIF1A PIK3CA NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 95%9636003 NEIL3-mediated resolution of ICLs NEIL3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 MBL2 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 COLEC11 MASP1 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QB C1QA C1S FCN1 C1R V4-6 V4-2 V4-1 C1QC FCN2 FCN3 CRP COLEC10 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation MRPS11 MRPS12 MRPL38 MT-ND6 MRPL39 MRPS10 MT-ND4 MRPL36 MRPL37 MT-ND5 MRPL34 MT-ND2 MRPL35 MT-ND3 MRPL32 MT-ND1 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MT-ATP6 MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 MT-ATP8 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 MTRES1 MTRFR NDUFAB1 MT-ND4L GFM1 GFM2 MRRF MT-CYB MTFMT MTRF1 TSFM MTRF1L MTIF2 MTIF3 MT-CO1 MT-CO2 MT-CO3 MRPS17 MRPS15 MRPS16 MRPS14 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME%R-HSA-166662.5 Lectin pathway of complement activation FCN3 FCN1 COLEC10 MBL2 MASP1 COLEC11 FCN2 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 95%8963691 Phenylalanine and tyrosine metabolism PAH ASRGL1 KYAT1 HGD TAT FAH HPD GSTZ1 QDPR IL4I1 PCBD1 ISOVALERIC ACIDEMIA%REACTOME%R-HSA-9914355.1 Isovaleric acidemia IVD TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 95%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 95%9638482 Metal ion assimilation from the host HBA2 HBB REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 95%418359 Reduction of cytosolic Ca++ levels ATP2A3 ATP2A2 ATP2A1 ATP2B4 SLC8A1 ATP2B3 SLC8A2 ATP2B2 ATP2B1 SLC8A3 SRI CALM1 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors PARK7 PPARGC1A PIAS4 NCOA2 DDX5 NPM1 TRIM28 SIN3A NRIP1 HIPK2 DAXX ZNF131 UHRF2 NCOA1 DDX17 CASP8AP2 CTBP1 MBD1 SAFB TOPORS CREBBP MRTFA NCOR2 BMI1 PIAS3 ING2 SUMO3 SUMO2 EP300 RING1 UBE2I PIAS1 SUMO1 RNF2 CBX8 PHC2 PHC1 CBX4 PCGF2 CBX2 PHC3 ZNF350 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 95%73929 Base-Excision Repair, AP Site Formation MBD4 H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 SMUG1 H2BC3 NEIL3 H3-4 H2BC1 NEIL2 POT1 TERF2IP NEIL1 H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system UBC RPS27A TLR2 B2M UBA52 MRC1 UBB ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111448 Activation of NOXA and translocation to mitochondria E2F1 PMAIP1 TP53 TFDP1 TFDP2 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC35B2 SLC26A2 SLC26A11 SLC26A1 PAPSS2 PAPSS1 SLC35B3 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions CYP2E1 CYP2F1 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2S1 CYP2D6 CYP2A7 CYP2A6 CYP2C19 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling TIAM1 LYN ARPC1B ARPC1A KALRN RHOA ROCK1 ROCK2 ARPC4 CFL1 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ARHGEF28 ACTG1 SDC2 ACTB CDC42 ITSN1 RASA1 YES1 PAK1 LIMK2 RAC1 HRAS LIMK1 FYN GRIN2B GRIN1 PTK2 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 95%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) PCNA AQR USP7 ZNF830 ERCC6 GPS1 COPS4 COPS2 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA ELL CDK7 ERCC3 ERCC2 MNAT1 UBB LIG1 RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 LIG3 RPA1 ERCC8 DDB1 RPA2 XPA COPS7B COPS7A XRCC1 POLE4 CUL4A RPA3 COPS3 PPIE COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 ERCC5 COPS8 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.4 Activation of kainate receptors upon glutamate binding GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GRIK5 GRIK3 GNG3 GRIK4 GRIK1 GRIK2 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD PLCB3 PLCB1 GNG10 DLG3 PLCB2 DLG4 CALM1 GNG12 GNG11 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918449 Defective visual phototransduction due to STRA6 loss of function STRA6 TTR RBP4 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LRP1 RETSAT APOA2 APOM APOA1 BCO2 APOA4 BCO1 HSPG2 AKR1B10 CLPS APOE RBP2 LRP10 LRP12 PNLIP SDC4 SDC2 SDC3 LPL RBP4 RBP1 LRAT LDLR AGRN GPIHBP1 AKR1C1 GPC1 APOC3 APOC2 TTR GPC3 LRP8 RDH11 GPC2 GPC5 AKR1C4 GPC4 GPC6 AKR1C3 APOB LRP2 PLB1 SDC1 EXPRESSION OF NOTCH2NL GENES%REACTOME DATABASE ID RELEASE 95%9911233 Expression of NOTCH2NL genes NOTCH2NLA NOTCH2NLC NOTCH2NLB ELANE RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 95%8949275 RUNX3 Regulates Immune Response and Cell Migration ITGA4 RUNX3 ITGAL CBFB SPP1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 95%5579030 Defective CYP19A1 causes AEXS CYP19A1 PYRIMIDINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%500753 Pyrimidine biosynthesis CAD DHODH UMPS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559585 Oncogene Induced Senescence CDKN2D CDKN2C CDKN2B UBA52 CDKN2A RB1 MAPK1 E2F1 E2F2 E2F3 CDK6 TFDP1 MAPK3 TFDP2 ETS1 CDK4 ETS2 UBB UBC SP1 TNRC6C ERF RPS27A MOV10 ID1 AGO3 AGO4 AGO1 MDM2 TNRC6A MDM4 TNRC6B TP53 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.6 Metabolism of serotonin MAOA ALDH2 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.4 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB14 RHOQ KIFAP3 RALGAPA2 RALGAPB RAB13 PRKAA2 KIF3A PRKAG1 PRKAG2 LNPEP PRKAG3 KIF3B PRKAB2 PRKAB1 YWHAB YWHAE C2CD5 EXOC8 EXOC7 AKT1 YWHAQ CALM1 YWHAG ASPSCR1 YWHAH EXOC4 YWHAZ EXOC3 SFN EXOC6 STX4 TBC1D1 EXOC5 SNAP23 TBC1D4 EXOC2 EXOC1 RALA RAB11A RAB4A MYO1C MYO5A VAMP2 AKT2 SLC2A4 RAB8A RAB10 RAC1 MYH9 GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 95%190861 Gap junction assembly GJB6 GJB5 GJB7 GJC1 GJC2 GJA3 GJA1 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJB2 GJD4 GJB1 GJD3 GJB4 GJB3 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.4 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190370 FGFR1b ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF22 TGFBR3 GIPC1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling CXCL8 CD86 CD80 IL10RA PTAFR CXCL2 STAT3 LIF IL1RN CXCL1 FPR1 CCL3L3 IL1R2 CCR5 CCL5 IL12B IL12A CCL4 IL18 CCL3 JAK1 IL1A CCL2 IL1B CCL19 IL10 CCR2 IL10RB CSF2 CCR1 IL1R1 CSF3 CCL22 TYK2 CCL20 TNFRSF1B FCER2 CXCL10 TNF ICAM1 PTGS2 IL6 TIMP1 TNFRSF1A CSF1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 95%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME DATABASE ID RELEASE 95%9845620 Enhanced binding of GP1BA variant to VWF multimer:collagen GP5 GP9 VWF GP1BA GP1BB TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 95%9830364 Formation of the nephric duct WFDC2 MECOM OSR1 FGF2 GATA3 HOXB4 ID4 BMP4 HOXA6 PAX8 LHX1 PLAC8 CTNNB1 NPNT PAX2 RET EMX2 PCDH19 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME%R-HSA-5083633.3 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 POMT2 POMT1 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 95%8865999 MET activates PTPN11 MET GAB1 HGF PTPN11 CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.5 Calnexin calreticulin cycle SEL1L PRKCSH UBA52 RNF185 GANAB PDIA3 EDEM2 UBB UBC DERL2 CANX CALR RNF5 RPS27A OS9 MAN1B1 RNF139 UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN ITGA2 GXYLT2 CDH2 PXN SERPINE1 STT3B CDH1 SOX2 EDIL3 ZEB1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702590 gilteritinib-resistant FLT3 mutants FLT3 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PEX12 PEX3 ACBD5 GDAP1 PEX13 PEX14 PXMP2 PXMP4 ABCD2 PEX11B ABCD3 PEX26 ABCD1 PEX2 ATAD1 PEX16 FIS1 PEX19 SLC25A17 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 95%171306 Packaging Of Telomere Ends H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 95%975577 N-Glycan antennae elongation B4GALT6 B4GALT4 B4GALT5 MGAT4A ST3GAL4 MGAT4B B4GALT1 ST8SIA6 ST8SIA2 B4GALT2 B4GALT3 MGAT5 ST8SIA3 ST6GAL1 MGAT4C OTHER SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-416700.3 Other semaphorin interactions TREM2 PLXNA2 ITGA1 SEMA3E SEMA4A CD72 SEMA5A SEMA4D PLXND1 PLXNC1 SEMA6A PLXNA4 SEMA6D PTPRC SEMA7A ITGB1 PLXNA1 TYROBP PLXNB3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 95%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9918485 Dengue Virus Attachment and Entry LY6E TIMD4 AP2A1 TYRO3 FURIN AP2A2 MERTK PIK3R1 UBA3 MAPRE3 EMC4 CD14 AP2M1 UBA1 HSPA5 CD33 HSPG2 CLDN1 CD209 SDC4 ATG7 SDC2 SDC3 AP2S1 AXL AGRN GPC1 AP2B1 UBA7 GPC3 HAVCR1 UBA6 GPC2 UBA5 MRC1 GPC5 GPC4 GPC6 RPSA PROS1 SDC1 CD300A GAS6 RNASEK RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation CCNT2 ELOB ELOC CCNH POLR2A CDC73 POLR2B POLR2C POLR2D CCNK POLR2E POLR2F SKIC8 POLR2G POLR2H POLR2I POLR2J CTR9 POLR2K RTF1 POLR2L GTF2H1 GTF2H2 LEO1 GTF2H3 SUPT5H PAF1 GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 AFF4 CDK9 MLLT1 TCEA1 MLLT3 SUPT6H IWS1 EAF1 EAF2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 CDK2 LMNB1 MLH1 UBE2I FIGNL1 TEX12 TEX15 MSH4 MSH5 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B MND1 FIRRM REC8 BLM SYCP3 MRE11 BRCA1 BRCA2 STAG3 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 SPO11 H2BC12L H2BC21 SUN2 SUN1 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 SMC1A RAD50 SMC3 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 STAG1 H2BC11 STAG2 ATM RAD21 ATR H3C15 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 95%1483101 Synthesis of PS PTDSS2 PTDSS1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) KCNK17 KCNK16 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins RPN2 ZDHHC20 TUSC3 PRMT1 PRKCSH RPN1 SRPK1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 UBE2I SUMO1 ST6GALNAC2 PARP10 PARP6 GSK3A PARP4 PARP16 GSK3B PARP9 ST6GAL1 CSNK1A1 PARP14 PARP8 UBA52 ST6GALNAC3 ST6GALNAC4 SRPK2 GALNT1 UBB UBC ST3GAL4 RPS27A ST3GAL1 ST3GAL2 ST3GAL3 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 95%9763198 Impaired BRCA2 binding to SEM1 (DSS1) SEM1 BRCA2 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%2029480 Fcgamma receptor (FCGR) dependent phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD ITPR3 WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 PLD1 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC PIK3CB IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 PIK3CA VAV1 VAV2 IGHG3 IGHG4 IGHG1 PLA2G6 IGHG2 PIK3R2 PIK3R1 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 PLD4 V2-19 MAPK1 V1-11 PLD3 V1-16 V1-13 ELMO2 MAPK3 PLD2 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 PRKCD DOCK1 BRK1 LYN BTK CFL1 PLPP5 PLPP4 ACTB MYO5A YES1 HCK SYK PAK1 AHCYL1 FYN NCKAP1L WASF1 PRKCE PTK2 WASF2 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 95%9909505 Modulation of host responses by IFN-stimulated genes IFI6 IKBKB IFI44L FKBP5 ARIH1 UBA7 HSPA5 RIGI CHUK ATF6 ISG15 IFIH1 UBE2L6 TRIM25 HERC5 IFI27 EIF2AK3 IKBKG RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 95%444821 Relaxin receptors INSL3 INSL5 RXFP4 RXFP1 RLN2 RXFP2 RLN3 RXFP3 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 PTK6 CDKN1A CCND1 CDK2 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis SLC2A1 B4GALT1 LALBA SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine AMDHD2 GFPT2 GFPT1 PGM3 NAGK GNPNAT1 UAP1 RENBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 95%73933 Resolution of Abasic Sites (AP sites) MBD4 PCNA SMUG1 PARP1 NEIL2 NEIL1 MPG PNKP LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 POLE FEN1 OGG1 RFC2 RFC1 PARP2 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLB POLE2 POLE3 PARG NTHL1 APEX1 TDG ADPRS SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.4 SHC1 events in EGFR signaling HRAS SOS1 HBEGF SHC1 TGFA AREG EGF EGFR NRAS EREG BTC EPGN PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation JUN XIAP RNF146 USP7 MBD3 TNKS GATAD2B GATAD2A PREX2 PTEN CHD4 SNAI2 RCOR1 TRIM27 WWP2 EED NEDD4 MKRN1 FRK HDAC5 USP13 MTA2 HDAC7 RBBP4 MTA1 REST MTA3 RBBP7 TNKS2 PML AKT2 OTUD3 HDAC1 HDAC3 KDM1A MAPK1 MAPK3 ATF2 EGR1 RPTOR TNRC6C MOV10 MLST8 SLC38A9 CHD3 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 HDAC2 TNRC6A TNRC6B MTOR RNF2 PSMD8 RRAGA PSMD6 RRAGC SUZ12 CBX8 PSMD7 PHC2 RHEB RRAGB PHC1 PSMD2 RRAGD NR2E1 CBX4 PSMD3 LAMTOR2 AKT1 CBX2 LAMTOR1 PSMD1 PHC3 LAMTOR4 LAMTOR3 LAMTOR5 MECOM PSMA5 STUB1 PSMA6 PSMA3 PSMA4 ATN1 PSMA1 SALL4 MAF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 SNAI1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 TP53 PPARG AKT3 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking NOSTRIN NOS3 WASL DNM2 CAV1 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME DATABASE ID RELEASE 95%964975 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes CREBBP MAFK NFE2L2 ABCC3 EP300 ABCF2 ABCC1 ABCG2 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 95%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA ASCC2 ASCC3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 UBE2D3 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBE2D1 UBA52 RPLP0 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 UBB RPS17 RPS15A RPS16 RPS19 UBC RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 ZNF598 RPS24 RPS27 RPS23 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-HSA-1855167.3 Synthesis of pyrophosphates in the cytosol NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 IPPK ITPK1 IP6K1 NUDT3 NUDT4 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9764302.3 Regulation of CDH19 Expression and Function SOX10 CTNNB1 JUP CDH19 CTNND1 ZC3H12A CTNNA1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 ARAP1 UBC PTK6 RPS27A DOK1 CBL AKT1 UBA52 UBB RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 95%9665247 Resistance of ERBB2 KD mutants to osimertinib ERBIN HSP90AA1 ERBB2 CDC37 SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis OGDH KGD4 DLST DLD PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 95%1912422 Pre-NOTCH Expression and Processing JUN H2BC9 H2AZ2 H4C9 SEL1L H2BC8 H2BC5 H2BC3 FURIN H2BC1 H2AC20 CCND1 ATP2A3 ATP2A2 MAMLD1 ATP2A1 RBPJ TMED2 TNRC6C RFNG MOV10 MFNG B4GALT1 AGO3 AGO4 SNW1 AGO1 AGO2 TNRC6A TNRC6B POGLUT1 POFUT1 ELANE E2F1 RAB6A E2F3 TFDP1 TFDP2 H2AX PRKCI SIRT6 ELF3 CREBBP NOTCH2NLA H2AB1 NOTCH2NLC MAML2 H2AC19 ST3GAL4 NOTCH2NLB MAML1 H2BC26 H2AC14 H2BC12L KAT2B H2BC21 KAT2A LFNG EP300 ST3GAL6 H3-3B H3C8 ST3GAL3 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TP53 H2BC11 MAML3 NOTCH2 NOTCH3 NOTCH1 NOTCH4 H3C15 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.3 p130Cas linkage to MAPK signaling for integrins APBB1IP TLN1 CRK FN1 SRC BCAR1 RAP1B RAP1A FGB FGA VWF PTK2 ITGB3 FGG ITGA2B ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 95%9026527 Activated NTRK2 signals through PLCG1 NTF4 NTRK2 BDNF PLCG1 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG PRKACA PRKACB AVPR2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RAB11FIP2 MYO5B AQP12A AQP10 AQP8 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 GNAS RAB11A AVP PRKAR1B PRKAR2B PRKAR1A PRKAR2A GNG10 GNG12 GNG11 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 95%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 CLOCK NPAS2 HELZ2 RAI1 CREBBP CHD9 NCOR1 MEF2C TBL1XR1 EP300 MED1 TGS1 MEF2D RORC RORA RORB SIRT1 PPARA CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli GNG13 YAP1 GNB2 GNAQ GNB1 RELA ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ABL1 ADCY1 SPP1 ADCY8 GNGT1 ADCY7 ADCY6 RICTOR ADCY5 GNGT2 PRKACG PRKACA PRKACB STAT1 PECAM1 GNG3 GNG2 NFKBIA GNG5 GNG4 GNG7 GNA11 GNG8 GJA1 NOS3 PRR5 P2RX7 TRPV4 GNAS PKN2 CACNG7 CAPNS1 CAPNS2 CAPN2 RAMP2 PPP2R1B PPP2R1A CALCRL PIK3CB ADM PRKAR1B PRKAR2B PRKAR1A PRKAR2A PDPK1 CACNB2 PIK3CA P2RY2 ITGB3 ITGB1 MAPKAP1 ITGAV ITGA5 CACNA2D1 PIK3R2 NFKB1 PANX1 HSPG2 CTNNB1 CHUK PTPN1 CACNB1 CACNB3 IKBKB PPP2CA MLST8 MTOR IKBKE AKT1 CALM1 FLT4 KDR IKBKG ANXA2 TLN1 PPP2R2A CDH5 VCL PIEZO1 PIK3CD FYN CACNA1H GNG10 PTK2 GNG12 MMP14 GNG11 SYNTHESIS OF DNA%REACTOME%R-HSA-69239.5 Synthesis of DNA ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 FZR1 SKP2 CCNE2 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 POLD3 POLD4 POLD1 POLE POLD2 RFC1 POLE4 POLE2 POLE3 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 ORC5 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes AIM2 BCL2 RELA BCL2L1 NFKB1 HSP90AB1 NLRC4 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 NLRP1 PYCARD NLRP3 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription CREBBP RBPJ MAML2 FABP7 MAML1 KAT2B HEY1 KAT2A HES1 SNW1 EP300 WWC1 HEY2 DLGAP5 HES5 PTCRA PLXND1 PBX1 HEYL MAMLD1 MAML3 STAT1 NOTCH3 NOTCH1 RAS PROCESSING%REACTOME DATABASE ID RELEASE 95%9648002 RAS processing ABHD17C FNTA ABHD17B BCL2L1 ABHD17A RCE1 NRAS PDE6D ICMT HRAS FNTB LYPLA1 PRKCQ ARL2 PRKG2 GOLGA7 KRAS USP17L2 CALM1 ZDHHC9 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 95%71387 Carbohydrate metabolism SLC26A2 SLC26A11 SLC26A1 PRKACG SLC2A1 PRKACA PRKACB G6PD B4GALT6 B4GALT5 FUT2 FUT1 TKFC B3GALT4 GALM PCK2 SLC37A1 G6PC2 G6PC3 FBP1 FBP2 SLC35B3 B4GAT1 LALBA SLC35B2 XYLT2 SLC35D2 XYLT1 B4GALNT2 B3GALT2 B3GALT1 FAM20B FUT4 FUT6 FUT5 FUT7 FUT9 B3GALT5 CHPF GALK1 PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 GALE CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 GCKR GCK PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 B3GAT3 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU B4GALT1 NDST4 TKT GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE NUP214 UBA52 MAN2B2 MAN2C1 UBB TALDO1 UBC ABCC5 RPS27A GAPDHS PGD PC GBE1 PYGM CEMIP STAB2 GYS2 LYVE1 PHKG1 HAS1 PHKG2 HYAL2 GYG2 HAS3 EPM2A GNS CHP1 AKR1E2 PHKA1 HAS2 SPAM1 PHKB PHKA2 PPP1R3C NHLRC1 GALT PYGB PYGL B3GALT6 SLC37A4 B4GALT7 ABO IDUA NCAN HEXB HEXA BGN AGL GLB1L3 DCN GLB1L2 BCAN NUP205 POM121 VCAN NUP107 GLB1L HYAL1 NUP188 GLB1 AAAS HYAL3 HYAL4 NUP160 POM121C AKR1B1 IDS CSPG5 NUP42 NUP85 CSPG4 TPR GUSB ARSB NUP62 GYG1 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 GYS1 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 RHCE PPP2R1B RHD PPP2R1A PGM2 PGM1 FUT3 PPP2R5D DERA G6PC1 B3GNT3 CHST14 DCXR AKR1A1 HSPG2 SORD CRYL1 XYLB MANBA GAA PCK1 ACAN LUM CD44 PPP2CA PPP2CB AGRN FMOD HK1 CALM1 GPI ADPGK ENO1 ENO2 ENO3 HK2 ENO4 HK3 TPI1 PGAM1 PGAM2 MAN2B1 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 ST6GALNAC6 PGK2 PFKL GNPDA1 GNPDA2 PFKM DSEL PFKP DSE UST CHST15 GLYCTK ST3GAL4 KHK SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 ST3GAL2 HMMR ST3GAL3 SLC9A1 UGP2 ALDH1A1 PRPS2 PRPS1 RPEL1 RPE CTSL SHPK PGLS PRPS1L1 RBKS SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 95%3108232 SUMO E3 ligases SUMOylate target proteins NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 NUP107 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG DNMT1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SNAP25 RAB3A STX1A SYT1 VAMP2 CPLX1 RIMS1 UNC13B CHAT PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC18A3 SLC5A7 TSPOAP1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events RBP4 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis FAR2 GNPAT DHRS7B AGPS AWAT1 AWAT2 FAR1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 95%167243 Tat-mediated HIV elongation arrest and recovery POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME DATABASE ID RELEASE 95%444411 Rhesus glycoproteins mediate ammonium transport RHBG RHCG RHAG INTESTINAL INFECTIOUS DISEASES%REACTOME%R-HSA-8942233.2 Intestinal infectious diseases GUCY2C NHERF4 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013409 RHOJ GTPase cycle ARHGAP26 MPP7 VANGL1 ARHGAP32 ARHGEF7 PIK3R2 PIK3R1 RHOJ ARL13B CDC42 CPNE8 STEAP3 WIPF2 FMNL3 FNBP1L GJA1 FNBP1 SCRIB LAMTOR1 TFRC IQGAP3 SNAP23 ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 SYDE1 OPHN1 GIT1 TMPO DOCK8 WASL OCRL DEPDC1B CDC42EP1 VAMP3 RAB7A TRIO WAS NIPSNAP2 SLC1A5 ARHGAP21 PREX1 STOM PAK1 PAK3 CDC42BPB CDC42BPA PAK2 PAK4 DIAPH3 GIT2 CAV1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-HSA-5173214.3 O-glycosylation of TSR domain-containing proteins ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 THBS1 SBSPON ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS13 ADAMTS14 ADAMTS19 ADAMTS18 ADAMTS17 SSPOP SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 POFUT2 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 THSD7A DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance DAXX ATRX INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA BANF1 PSIP1 HMGA1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 95%8875555 MET activates RAP1 and RAC1 RAC1 RAP1B RAPGEF1 RAP1A CRK MET GAB1 DOCK7 HGF CRKL DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 95%180024 DARPP-32 events PPP2CA PPP2CB PPP1R1B PPP2R5D CDK5 PRKAR1B PRKAR2B PPP3CC PRKAR1A PDE4A PPP1CA PRKAR2A PDE4D PDE4C PPP3CA PRKACG PPP3CB PRKACA PRKACB PPP3R1 CALM1 PPP2R1B PPP2R1A SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling PRKCA SOS1 HBEGF SHC1 EGF ERBB2 EGFR NRAS NRG1 HRAS PRKCE EREG NRG3 NRG4 PTPN12 NRG2 BTC PRKCD MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 95%9953097 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 95%5674400 Constitutive Signaling by AKT1 E17K in Cancer CDKN1A RPS6KB2 CDKN1B RICTOR CHUK FOXO4 BAD MLST8 FOXO6 FOXO1 AKT2 TSC2 MDM2 NR4A1 MTOR PRR5 PDPK1 FOXO3 AKT1S1 GSK3A AKT1 CASP9 GSK3B MAPKAP1 AKT3 HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones RUVBL1 KANSL1 KANSL2 KANSL3 H2AC1 EP400 KAT7 ATXN7 SUPT20H ATXN7L3 TADA3 ING4 ING3 PAX3 OGT SUPT3H TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 WDR5 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 RUVBL2 KAT6B MORF4L2 HAT1 ENY2 TAF5L H2BC18 DMAP1 MRGBP TAF9 TADA1 VPS72 MSL2 MSL3 MSL1 TAF12 RBBP7 H2AC19 H2BC26 H2AC14 USP22 H2BC21 TAF10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 H3C15 H2BC9 BRPF1 H4C9 BRPF3 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 ATF2 PHF20 ING5 SAP130 KAT8 TRRAP H2AC17 BRD1 H2AC12 KAT14 MEAF6 ZZZ3 HCFC1 TADA2A SGF29 NCOA2 TADA2B H2AC25 EPC1 H2AC21 KAT5 ACTB CLOCK ACTL6A CREBBP YEATS4 MBIP DR1 KAT2B KAT2A YEATS2 KAT6A MCRS1 CALMODULIN INDUCED EVENTS%REACTOME DATABASE ID RELEASE 95%111933 Calmodulin induced events PRKCA ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A CAMK2B CAMK2D PRKAR1B CAMK2A PRKAR2B PRKAR1A PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG NBEA CALM1 CAMK2G PRKCD IRS ACTIVATION%REACTOME DATABASE ID RELEASE 95%74713 IRS activation INS GRB10 IRS1 INSR IRS2 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 95%1169092 Activation of RAS in B cells HRAS RASGRP3 NRAS RASGRP1 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418594 G alpha (i) signalling events CXCL6 CXCL9 CXCL8 TAS2R10 CXCL13 TAS2R13 CXCL3 TAS2R14 CXCL2 TAS2R16 ADCY9 CXCL5 CX3CL1 GNAL ADCY4 CXCL16 ADCY3 CCR9 ADCY2 CCR8 ADCY1 CCR7 ADCY8 KNG1 CCR4 ADCY7 CCR3 ADCY6 CCL13 ADCY5 CX3CR1 PRKACG CXCR5 CCR5 CXCR6 PRKACA CXCR4 PRKACB CCR6 CCL5 PPBP CXCR3 CCL4 RGSL1 OPN3 CCL1 RRH TAS2R40 CCL19 TAS2R41 CCR2 RGR TAS2R43 CCL16 OPN5 PLA2G4A TAS2R46 CCR10 CCL25 CCR1 CCL21 FPR2 CCL20 CXCL10 PDE1B CXCL11 RXFP4 PDE1A CXCL12 ITPR1 GPR17 ITPR2 ACKR3 TAS2R30 ITPR3 TAS2R31 CCL28 RXFP3 CCL27 PSAP TAS2R38 NMS PDYN NMU AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 NPBWR2 GPR183 PNOC GPR18 SSTR3 GPR37 ANXA1 GPR31 PLCB4 GNAS GPR55 MTNR1A TAS2R50 MTNR1B MCHR1 RLN3 LPAR1 LPAR2 LPAR3 LPAR5 PPP3CC MT-RNR2 CHRM2 INSL5 PENK S1PR3 S1PR2 APLN GPR37L1 CHRM4 S1PR5 TAS2R19 S1PR4 PMCH TAS2R42 RGS4 TAS2R45 RGS5 PPY RGS3 RGS1 TAS2R60 CASR OXGR1 GAL MCHR2 NPB NPW NMUR2 NMUR1 NPY2R NPY1R APLNR PRKAR1B SUCNR1 BDKRB2 PRKAR2B HCAR2 BDKRB1 PRKAR1A HCAR3 PRKAR2A PRKX HCAR1 PPP3CA PPP3CB GNAT2 PYY RGS18 TAS2R9 RGS17 PLCB3 RGS19 PLCB1 HEBP1 RGS13 PLCB2 RGS16 P2RY12 GRM3 PPP3R1 P2RY13 P2RY14 GRM2 GRM7 P2RY4 RGS21 ADORA3 GRM6 ADORA1 GPER1 GRM8 NPY5R SSTR1 SSTR2 HRH4 SSTR4 SSTR5 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 HTR1E CNR2 CNR1 HTR1F OPRD1 HTR1D HTR1B ADRA2C HTR5A ADRA2B C5AR1 ADRA2A C5 TAS2R7 PTGDR2 PTGER3 TAS2R8 AGT GRM4 TAS2R1 TAS2R3 PRKCD TAS2R5 PRKCA TAS2R4 PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG GNG10 NBEA GNG12 GNG11 GNG13 GNB2 GNAQ C3 GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 OPN1LW GNAZ GNA14 GNG3 CDK5 GNA15 OXER1 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 OPN1MW RGS11 RHO GNAT1 PPP2R1B PPP2R1A PPP2R5D NPY MAPK1 GNAT3 PPP2CA PPP2CB PPP1R1B CXCR1 CCL4L2 CXCR2 RGS8 CAMK2B PCP2 CAMK2D SRC GPSM1 GPSM2 CAMK2A PDE4A GPSM3 PDE4D PDE4C GNAI3 RGS14 RGS20 GNAI1 RGS22 RGS10 GNAI2 RGS12 OPRM1 SST CALM1 CAMK2G OPN1SW GABBR2 GABBR1 OPRK1 POMC CXCL1 PPP1CA TAS2R20 CAMK4 APP SAA1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 GLUL SLC38A1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies ACSS3 BDH2 BDH1 HMGCL HMGCS2 HMGCLL1 AACS ACAT1 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 NUP214 POM121C NUP42 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 LYN PLCG2 PLCG1 EPO EPOR IRS2 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.2 Defective F8 accelerates dissociation of the A2 domain F8 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 MTA2 ERCC6 RBBP4 MTA1 MBD3 MTA3 TTF1 RBBP7 H2AX EHMT2 GATAD2B GATAD2A H2AB1 H2AC19 H2BC26 H2AC14 CHD3 H2BC12L H2BC21 CBX3 H3-3B H3C8 HDAC2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CHD4 H3C15 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%70921 Histidine catabolism HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD HNMT MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) ATF5 HSPE1 HSPD1 ESR1 LONP1 CAT NRF1 DEFA5 HSF1 DNAJA1 HSPA1A SOD2 SIRT3 FOXO3 AKT1 HSPA9 HSPA1B HTRA2 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 95%5663020 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 95%880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate L2HGDH ADHFE1 D2HGDH NUCLEAR ENVELOPE BREAKDOWN%REACTOME%R-HSA-2980766.4 Nuclear Envelope Breakdown NUP85 PRKCA TPR NUP62 BANF1 PLK1 NUP88 NUP43 RAE1 CCNB1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 VRK1 CDK1 NUP153 LEMD2 NUP93 NUP50 NUP35 EMD NUP54 LMNB1 NUP37 LEMD3 CNEP1R1 LPIN1 LPIN2 LPIN3 PRKCB NUP205 CCNB2 POM121 NEK9 NUP107 NEK6 NUP188 NEK7 AAAS NUP160 NUP214 POM121C NUP42 S PHASE%REACTOME%R-HSA-69242.5 S Phase ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 CDCA5 RB1 CDKN1B FZR1 E2F1 RBBP4 SKP2 CABLES1 ESCO1 ESCO2 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 POLA1 POLA2 LIG1 CKS1B MAX POLD3 POLD4 POLD1 POLE POLD2 RFC1 AKT2 PDS5B SMC1A SMC3 PDS5A WAPL POLE4 STAG1 STAG2 RAD21 POLE2 POLE3 PTK6 CDKN1A CDC25B CCND1 CDK2 GINS1 GINS2 CDC45 GINS3 GINS4 FEN1 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 GSK3B RBL2 ANAPC15 ANAPC16 ANAPC7 CCNH UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC RFC5 PSMB1 RFC3 RFC4 RPS27A RFC2 ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 DNA2 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 95%5633231 Defective ALG14 causes ALG14-CMS ALG14 ALG13 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones ATP6V0D1 SRPRB TPP1 PREB CXXC1 HDGF PPP2R5B KDELR3 SHC1 ADD1 DCTN1 HSPA5 SEC31A ERN1 EXTL2 PLA2G4B EXTL3 HYOU1 GSK3A ACADVL PDIA6 DNAJB11 SERP1 WFS1 TLN1 DNAJC3 CUL7 FKBP14 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 CTDSP2 SRPRA MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 95%5389840 Mitochondrial translation elongation MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 TSFM MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 MRPL45 MRPS6 MRPL46 MRPS5 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 TUFM MRPL12 MRPL57 MRPL13 MRPL54 MRPL10 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 KGD4 MRPL30 GFM1 MRPS17 MRPS15 MRPS16 MRPS14 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 95%69541 Stabilization of p53 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 CDKN2A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PHF20 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 MDM2 PSMC5 MDM4 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 95%4085011 Defective GNE causes sialuria, NK and IBM2 GNE CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.4 Class B 2 (Secretin family receptors) FZD2 GNG13 FZD5 FZD7 WNT5A FZD4 GNB2 WNT16 FZD6 GNB1 WNT1 FZD1 GNB4 FZD8 GNB3 PTHLH GNB5 GNGT1 GNGT2 GIP IHH SMO PTCH1 GNG3 FZD10 GNG2 GNG5 GNG4 GNG7 CRHBP ADCYAP1 GNG8 ADCYAP1R1 CD55 WNT10A FZD9 UCN PTH1R UCN3 UCN2 PTH2R WNT7B GNAS CRH WNT7A GCGR GCG PTH2 WNT3A ADGRE5 ADGRE3 WNT9A GLP1R SHH VIPR1 DHH VIPR2 CRHR1 SCT WNT3 RAMP2 GIPR CALCA GHRHR GLP2R RAMP3 WNT8A CALCB WNT8B SCTR CALCR GHRH CALCRL VIP ADM2 ADM IAPP RAMP1 PTH WNT10B WNT9B WNT6 WNT4 WNT2 PTCH2 WNT2B ADGRE1 GNG10 ADGRE2 WNT11 GNG12 FZD3 GNG11 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811438 Intra-Golgi traffic STX5 BET1L GOLIM4 RAB33B RAB41 GOLGA5 ARF1 NAPA NAPB COG8 COG7 COG6 STX16 NSF COG5 MAN2A1 COG4 GOSR1 COG3 NAPG COG2 COG1 CYTH3 RAB30 CYTH2 RAB36 CYTH4 CUX1 MAN1C1 SNAP29 STX6 MAN2A2 VTI1A CYTH1 RIC1 RAB39A RGP1 ALPP TRIP11 GOSR2 MAN1A2 VPS45 YKT6 MAN1A1 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%5173105 O-linked glycosylation B3GNT5 B4GALT6 B4GALT5 MMRN1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 ADAMTS13 GALNT10 GALNT9 POMT2 GALNT8 B3GALNT2 B3GNT9 QTGAL SLC35A4 B3GNT8 FKRP CRPPA B3GNT6 GALNT1 POMT1 CHST4 POMGNT2 GCNT1 POMGNT1 GCNT3 B4GAT1 GCNT4 MGAT5B GCNT7 CHST10 GALNT7 GALNT6 POMK DAG1 GALNT5 RXYLT1 GALNT4 LARGE1 A4GNT LARGE2 GALNTL5 GALNTL6 FKTN GALNT2 POFUT2 B3GNT7 B3GNT4 B3GNT2 POFUT4 POFUT3 EMID1 MMRN2 MUC13 B3GNT3 GALNT12 SEMA5A SPON2 SEMA5B SPON1 ST6GALNAC2 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 ST6GAL1 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON THBS1 MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ST6GALNAC3 ADAMTS14 ST6GALNAC4 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 95%597592 Post-translational protein modification NR5A1 PCNA SEL1L RELA CP NPM1 RNF185 NR3C1 SP100 DERL1 DERL2 RNF5 RAB9A RAB9B OS9 VDR ARF4 IL6 SENP5 SENP2 NOP58 CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 SHISA5 PDIA6 MXRA8 SPARCL1 AURKA SCG2 GBF1 TGOLN2 STC2 PENK RAB11A IGFBP7 NDUFAB1 AMELX POMT2 WFS1 B3GALNT2 AMBN ZNF131 TMEM132A SLC35A4 FUCA2 UHRF2 FKRP HRC CRPPA DDX17 CASP8AP2 POMT1 MELTF MBD1 SERPINA10 POMGNT2 MIA3 SAFB POMGNT1 B4GAT1 MSLN TOPORS PRSS23 MGAT5B CHRDL1 CHST10 BMP15 POMK DAG1 RXYLT1 LARGE1 MEPE LARGE2 DNAJC3 B4GALNT2 RCN1 FKTN PIAS3 VGF ENAM AMTN VWA1 FAM20C FAM20A DDB1 MFGE8 UBE2V2 ITIH2 COPS7B SERPINC1 XPC AFP COPS7A FSTL1 FSTL3 CST3 APOL1 CUL4A TOP2B TOP1 SERPIND1 COPS3 GOLM1 POFUT2 COPS6 COPS5 NUCB1 NOTUM UBE2N POFUT4 COPS8 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 LYPD6B PIGO DCTN6 PIGN DCTN5 PIGP DCTN1 PIGZ DCTN4 PIGW NR3C2 PIGV PIGY PIGX LRRC49 PIGC PIGB CAPZA3 PIGA PIGM PIGL CAPZA2 PIGG PIGF ACTR10 PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 SQSTM1 TTLL1 CHM TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H TFAP2B ING2 SPRN SPACA4 TFAP2C NICN1 UBE2I MDGA2 SUMO1 RECK MDGA1 NRN1 ART3 UBE2D2 ART4 UBE2D3 NTNG1 NTNG2 HIF3A RAB22A CD59 CD52 CD55 ELOB PRND ELOC RBX1 CNTN5 ALPL EPAS1 CNTN3 CNTN4 CUL2 ALPG HIF1A TEX101 VHL RAB40A RAB40B ZNF350 RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 ACTB PTP4A2 DCAF7 RTN4RL1 TTL TUBB6 RAB20 TUBB3 RAB25 TUBB1 RAB26 FBXO4 SVBP RAB23 FBXO6 RAB29 RAB15 RAB19 RAB17 FBXW4 TTLL10 FBXW5 NFU1 FBXW10 TTLL13 MEN1 TTLL11 FBXW7 TTLL12 FBXW9 IGFBP1 UMOD LIAS OTOA FBXW2 RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C TP53 LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FBXL3 EIF5A FBXL5 DHPS FN3KRP EIF5A2 TUBA1C FN3K TUBA1B ICMT DOHH TUBA1A TUBB2B FUCA1 TUBB2A USP11 TUBA3E TUBA3D TUBA3C TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 WDR5 RAB3D AAAS NUP160 POM121C NUP42 RAB44 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB31 NUP155 RAB37 NUP133 NUP210 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 HDAC7 NUP54 RAB6A TRAPPC1 RBBP5 RAB4B NUP37 RBBP7 CDC20 FCGR3B MRTFA PML DYNC1LI1 DYNC1LI2 RAB24 CDCA8 RAB10 RAB18 COMMD9 DYNLL1 PARP1 BST1 RANGAP1 VNN1 DYNLL2 CTSZ RHOA INCENP BIRC5 CTSC PRMT3 DYNC1I2 COMMD3 AURKB KCTD6 DYNC1I1 DYNC1H1 NR4A2 THRB TFG COPB1 NR2C1 THBS1 GOLGB1 NFKB2 FGA PLAUR FGG CAND1 ANK1 F7 F9 PROC F10 GGCX SKP1 CCNA2 PROS1 PROZ CCNA1 F2 GAS6 CUL1 DBT PCSK9 APOA2 APOA1 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB LAMB2 FN1 LAMB1 LAMC1 BTRC ADAMTS13 MTA1 RPS2 RPS6 EEF1A1 B4GALT2 B4GALT3 LRR1 CCNF B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B CDC34 PSME1 UBE2J2 SEC31A FBXL8 CALR FBXL4 LRRC41 GAN RRAGA SOCS2 SOCS6 KLHL2 KLHL3 IKBKE UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 CETN2 ACTR1A FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 CSNK1D FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 DCTN2 CUL7 CUL5 UBA6 DCTN3 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F YKT6 UBE2H KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W JMJD6 UBA3 RIOX2 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A ANO8 RNF168 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ANKRD28 ASPH ASB9 ASB6 ASB7 PPP6C PPP6R3 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 TP53BP1 GALNT1 ARFGAP3 ARFGAP2 COP1 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SMC1A SEC31B SMC3 TRAPPC2 SEC16B TRAPPC3 TPST2 KTN1 SEC16A STAG1 TPST1 TRAPPC5 TRAPPC9 STAG2 RAD21 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 TDG CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RAD52 RPL8 DCAF13 MATN3 CHD3 BMI1 SUMO3 SUMO2 RING1 PIAS1 HDAC4 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 PCGF2 CBX2 PHC3 AMER1 RPL27A AXIN1 APC CDC73 NCOA2 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 PNPLA2 CTBP1 RWDD3 UBA2 DNMT1 SAE1 CREBBP AREG NFE2L2 DNMT3B TGFA DNMT3A EIF2AK2 STS MGAT3 ETF1 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG APOB ARSD UBE2L3 USO1 TUBB8 RAB2A TUBB8B SPTAN1 RAB1A RAB1B HGS RAB5A TOP2A GORASP1 UBE2T OTULIN FDX1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 FUT8 MITF GANAB ADAM10 MAN2A1 MGAT5 MGAT1 FBXL18 FBXL7 MGAT2 OST4 EDEM2 ARF3 MOGS DDOST SDC2 MGAT4C TMEM258 DAD1 OSTC MGAT4A TMED2 CANX MGAT4B STT3A STT3B MAN1B1 GPC3 TRRAP CCP110 KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR DCAF8 RNF128 DCAF5 VDAC3 DCAF4 VDAC2 PIAS4 DCAF6 VDAC1 WSB2 CFTR GATA3 OBSL1 BRCC3 DCUN1D5 SNX3 DCUN1D3 RHOT1 DCUN1D4 RCE1 DCUN1D1 DCUN1D2 ZRANB1 COMMD8 SIAH2 INO80 PUM2 ARF1 NPLOC4 STAM DDA1 TADA2B CYLD ANKRD9 H2AC25 UBXN7 COMMD2 H2AC21 COMMD1 BAP1 COMMD6 WDR48 OTUD7A COMMD7 OTUD7B COMMD4 BABAM1 COMMD5 RAB4A SPSB3 IFIH1 CCDC8 BABAM2 CISH UCHL1 TRIM4 CUL9 UIMC1 DPP3 UFD1 UBD IKBKG NAE1 SOCS5 TOMM70 RIPK2 WDTC1 ACTL6A CCDC22 JOSD2 COMMD10 TULP4 UCHL3 JOSD1 DCAF16 DCAF17 UCHL5 DDB2 FEM1C KAT2B DCAF10 KAT2A DCAF11 PTRH2 FEM1A FEM1B PRKN CAPZA1 WDR20 NEURL2 PSME2 NEDD8 ERCC8 USP17L21 USP17L20 GOSR2 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 USP17L12 ARFGAP1 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 PREB OTUD5 TOMM20 YY1 KDELR3 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS RWDD1 JMJD4 ADRB2 KDM8 FOXO4 VCPIP1 JMJD7 ATXN3 RIOX1 ATXN7 OGFOD1 DRG1 NLRP3 DRG2 RIPK1 RCCD1 SUDS3 CLSPN ZC3H15 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 STX5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 IDE USP25 USP26 CAPZB USP20 USP21 RAB32 USP22 TAF10 RAB35 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 SCFD1 SPTBN1 RAB39B PARK7 MUC13 RAB8B INS RAB33A RAB7B FGF23 RAB21 CHML RAB11B RAB12 RAB13 ALPI GRIA1 HNRNPK CKAP4 SENP1 CALM1 UBE2C UBE2E1 UBE2D1 UBE2S CDK1 DLAT BLM PIGS BRCA1 PIGU PGAP1 PIGT WRN GPAA1 PIGK BARD1 CDH2 METTL21A KIN FBXW11 METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT RPA1 EEF1AKMT2 EEF1AKMT1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 DDX5 RAB41 KNG1 COG8 COG7 COG6 COG5 COG4 RAB27B COG3 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG MAN1A2 F5 F8 TMED3 MMRN1 MAN1A1 TMED7 TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B U2AF2 GALNT11 ARF5 GALNT14 NAPA GALNT13 NAPB GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GOSR1 NAPG GALNT8 GOLGA2 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 BPIFB2 GCNT1 GCNT3 GCNT4 GCNT7 MAN1C1 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNT2 GALNTL6 ARCN1 COPG2 COPG1 LTBP1 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A COL7A1 MDC1 SPTB B4GALT1 DTL MYC ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 PSMD3 PSMD1 SPTBN2 NUP214 PSMD9 PSMD4 PSMA5 PSMD5 PPARGC1A PSMA6 PSMA3 PAAF1 PSME3 PSMA4 PSME4 PSMA1 PSMD10 PSMA2 PSMB11 POMP PSMA8 PSMF1 UBA52 PSMG3 PSMG4 PSMD12 PSMG1 PSMD11 PSMG2 PSMD14 PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 FOXL2 PSMC2 HIC1 SP3 PPARG PPARA LY6E PEX10 SRD5A3 PEX12 C3 PEX13 PEX14 FURIN BGLAP SPP1 IL33 RNF20 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC HLA-A RORA DLST VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT H2AC19 H2BC26 H2AC14 H2BC21 EP300 SOCS3 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 RARA ETFB RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 FBXO32 H2BC1 H2AC20 KDM1B NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 RABGGTB RABGGTA GALNT12 DPAGT1 SEMA5A ST6GALNAC1 SPON2 SEMA5B CMAS ST6GALNAC2 SPON1 THSD7B MPI ADAMTS4 HK1 ADAMTSL1 GMPPB NANP ADAMTS5 C1GALT1C1 FPGT ADAMTS2 GMPPA PGM3 ADAMTS3 ADAMTSL5 GNPNAT1 ADAMTSL4 GFUS NANS ADAMTS1 NUDT14 ADAMTSL3 ALG8 ADAMTSL2 ST6GAL1 MUC12 THSD7A ST6GAL2 ALG9 MUC15 ALG6 ADAMTS8 ALG5 ADAMTS9 ADAMTS6 SLC35C1 ADAMTS7 ALG14 ALG2 SBSPON ALG3 MUCL1 MUC3A ALG13 MUC5AC ALG12 MUC3B ALG11 ADAMTS20 ALG1 B3GLCT ALG10 CFP RENBP TRIM28 DHDDS THBS2 ADAMTS12 DPM1 THSD1 DPM2 THSD4 DPM3 ADAMTS10 RFT1 ADAMTS16 MVD ADAMTS15 ST6GALNAC3 ADAMTS14 ALG10B ST6GALNAC4 MUC1 ST6GALNAC5 MUC2 ADAMTS19 ST6GALNAC6 ADAMTS18 GNE ADAMTS17 UAP1 NPL MUC7 FUOM MUC4 NEU2 MUC6 NEU3 MUC16 NEU4 GALNT3 MUC17 DHRSX C1GALT1 GMDS AMDHD2 MUC19 NEU1 SSPOP MUC5B ST3GAL4 ST8SIA4 MUC20 MUC21 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 DPH1 ST3GAL2 DPH2 FBXL21P ST3GAL3 DPH3 MPDU1 DPH5 CTSA DNAJC24 DPH6 NUS1 SLC35A1 DPH7 PMM1 EEF2 ST8SIA1 UBXN1 ST8SIA2 NGLY1 GFPT2 RNF139 PMM2 MLEC ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 95%9603505 NTRK3 as a dependence receptor BAX NTRK3 NELFB DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9630221 Defective NTHL1 substrate processing NTHL1 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AA1 HSP90AB1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase CCNH PTK6 CDKN2D LYN CDKN2C CDKN1A CDKN2B UBA52 CDKN1C ABL1 CDKN2A RB1 CDKN1B CCND3 CCND2 CCND1 E2F1 E2F2 E2F3 CDK2 SKP2 JAK2 CDK7 CDK6 TFDP1 CCNE2 TFDP2 MNAT1 CDK4 CCNE1 UBB PPP2R1B PPP2R1A CKS1B PPP2CA PPP2CB UBC PPP2R2A RPS27A E2F4 PPP2R3B E2F5 SKP1 CUL1 RBL2 RBL1 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 FUT2 FUT1 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 ABO FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 RHCE RHD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence LIG1 BRCA1 TERT MCM5 MCM2 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions LIFR CRLF1 TYK2 IL6ST LIF IL11 OSM OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA CTF1 CLCF1 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways TAS2R10 SEL1L TAS2R13 TAS2R14 TAS2R16 AVPR1B TAS2R40 AVPR2 TAS2R41 TAS2R43 AVPR1A TAS2R46 DERL2 ERLEC1 OS9 TAS2R30 TAS2R31 TAS2R38 TAS2R39 SSTR3 TAS2R50 MCHR1 PRKCI SIRT6 ELF3 NOTCH2NLA NOTCH2NLC NOTCH2NLB TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN FGD1 FGD2 DNAJB1 GNA13 FGD3 PTGES3 ABR FGD4 MAPK8 BCL2L11 ECT2 ARHGEF33 FKBP4 NGFR ARHGEF35 ARHGEF37 SOCS1 BAD ARHGEF39 MCF2 ARHGEF38 NET1 IKBKB SQSTM1 CYP26A1 MYD88 CYP26B1 CYP26C1 WWOX TAS2R7 TAS2R8 UBE2D2 UBE2D3 RBX1 EPAS1 HIF1A GRM4 VHL TAS2R1 TAS2R3 TAS2R5 TAS2R4 FES PIP5K1C POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 ACTB TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 CSNK2A1 CSNK2A2 CSNK2B TP53 ARL2 GNG10 CHD8 CBY1 GNG12 SOX3 GNG11 SOX17 GNG13 SRY CCT6A GNB2 SOX6 GNAQ SOX7 GNB1 SOX4 BCL9L CTNNBIP1 GNB4 SOX13 GNB3 PYGO1 BCL9 GNB5 PYGO2 GNGT1 ICMT TUBA1B GNGT2 SPHK1 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 NUP107 AAAS NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 HECW1 ERCC6L ZWILCH KLHL12 BUB1B WNT3 ACTG1 CCDC88C CDC20 DACT1 WNT8A PPP1CC WNT8B PPP2R1B PPP2R1A CXXC4 KNTC1 MRTFA KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 DAAM1 ZW10 PFN1 MAD1L1 PFN2 CDCA8 PMF1 SKA1 SKA2 DSN1 DVL1 DVL2 DVL3 SRGAP2 SCAI RCC2 NDC80 ZWINT DIAPH1 KIF18A RPS27 DIAPH3 ITGB1 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RHOC RANGAP1 RHOD CKAP5 DYNLL2 RHOA RHOB KIF2A INCENP BIRC5 EVL KIF2C KIF2B CHUK MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 SRF MIS12 CENPA AURKB NSL1 CENPC CDC42 PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 MTMR4 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 FMNL3 CENPE DGKG CENPF DGKE DAGLA FMNL1 DGKD FMNL2 CENPH DGKB CENPI DGKA TAOK1 ABHD6 CENPK ABHD12 CENPL PRKCH CENPM DGKZ CENPN DGKQ DAGLB B9D2 CENPO DGKK CENPP DGKI CENPQ DGKH SPC24 SPC25 MAD2L1 DUSP8 CENPS DUSP9 FLT1 FLT4 MRAS KDR VEGFB PORCN VEGFC VEGFD PGF NF1 VEGFA DUSP10 ESRP1 GNA12 SHOC2 SPRED3 SPRED2 SPRED1 CCNT1 CD274 IL2RG NELFB KANK1 STRN MAP2K5 NCBP1 NRP2 NCBP2 CDH5 CDK9 ADH1C CRABP2 ADH1A LFNG CRABP1 JAG1 SDR16C5 ADH4 RDH11 RDH10 RDH16 WNT9B RDH14 RDH13 DLL1 AKR1C3 DHRS3 WNT4 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 SKP1 ALDH8A1 FGFRL1 CUL1 FLRT2 FLRT1 EVC2 IQCE EFCAB7 EVC BOC GAS1 NTRK3 DRC4 PMEPA1 BAMBI NTF3 CDON STRAP WWC1 NEURL1B DLGAP5 HES5 PTCRA RASGRP2 MIB2 RASGRP1 PBX1 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 TACC3 RAF1 PRKACA PRKACB RAPGEF3 RAPGEF4 CYSLTR1 TRPC7 TRPC6 PLCG2 TRPC3 RCOR1 LAMA5 LAMA2 SH3KBP1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 CHRM2 JAK3 CHRM3 CHRM1 CHRM4 CHRM5 HNRNPA1 LIMK2 RPS6 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 NOTCH2 NOTCH3 NOTCH1 NOTCH4 GPNMB LRRK2 PTK6 RACK1 HBEGF TRAF1 HSP90AB1 TWF1 OPRD1 MSI2 RHOBTB2 ACTN1 TMOD3 LYPLA1 DDX39B RBCK1 PHIP FSHB INHBB INHBA INHA PRKAA1 PRKAA2 PTPRK EPS15L1 CAB39 EPN1 CAB39L PRKAG1 SPRY1 PRKAG2 PTPN3 PRKAG3 RPTOR STK11 EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B PRKAB2 STRADA STRADB TSC2 TSC1 PRKAB1 MTOR LRRC41 FKBP1A PPM1A RRAGA RRAGC RPS6KB1 RHEB RRAGB RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 CYFIP1 NCKAP1 NCF1 TFRC NCF2 NCF4 SNAP23 KBTBD7 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 FST ARHGDIB RAC3 FOXH1 ACVR1B EMD LBR ACVR2B GIT1 ACVR2A DRAP1 TMPO SWAP70 ACVR1C ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 RNF41 GARRE1 AMIGO2 NOXO1 CUL5 ARHGAP17 WDR83 SLC1A5 SYNGAP1 ARHGAP15 PAQR3 ARHGAP21 RGL3 LMAN1 RGL2 PAK1 PEA15 PGRMC2 DUSP5 RACGAP1 DUSP2 SLITRK3 DUSP1 NHS ABL2 IL17RD RAPGEF2 SLITRK5 DAB2IP NCKAP1L SEPTIN7 WASF1 CDC14B PAK2 RAG2 YKT6 RAG1 WASF2 PAK4 RASAL1 IL32 RASAL3 GIT2 RASGRP4 CAV1 RASGEF1A ETV4 MCAM RASA3 ERBIN RASA4 ARHGAP26 RASA2 BAIAP2 MPP7 ABHD17C VANGL1 IGF2BP1 MAPK6 ARHGAP32 MAPK4 ABI2 TAOK3 ANGPT1 NOXA1 ABHD17B ABHD17A ABI1 TEK NOX3 ESYT1 FERMT2 NOX1 TGFB1 UBE2M TGFBR1 TGFBR2 LMNB1 CPNE8 OXER1 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG TAX1BP1 FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 SRGAP1 STARD13 JUP ARHGAP29 ARHGAP27 ARHGAP24 STMN1 ARHGAP33 RBFOX2 ARHGAP31 PDGFD DNMBP SHB ARHGAP30 MAP3K11 FGFBP3 FGFBP1 CDC42SE2 FGFBP2 DOCK6 ARHGAP9 ARF6 ARHGAP11B ALKAL2 ALKAL1 DUSP16 DOCK9 TIA1 DOCK8 TNK2 DOCK7 WASL ADAP1 ARHGAP4 ESRP2 SH3PXD2A PTPRZ1 RAMP2 TAGAP CSN2 CALCA PLEKHG3 TIAL1 RAMP3 PLEKHG4 SH2D2A CALCB PLEKHG1 PAG1 CALCR RANBP10 CALCRL ARAP1 GMIP ADM2 PTPRO ARFGAP3 PTN ADM ARFGAP2 IAPP AXL PLAT RAMP1 ARHGAP10 FAM83D CDC42EP5 FAM83A CDC42EP4 MXD4 CDC42EP3 LTK CDC42EP2 THBS4 WAS THBS3 PARD6A PLEKHG4B CHN1 PAK6 STOM PAK3 PAK5 FARP1 MYO9B CDC42BPB CDC42BPA DEF6 KTN1 SHKBP1 DLC1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B ITGAV COL4A2 NCAM1 ITGA5 COL4A1 PTPRS SPARC ITGB5 SERPINE1 SPOP ITGB6 ITGA2 ITGA8 TGFB2 TGFB3 COL9A1 COL9A3 COL9A2 CHD3 BMI1 RING1 HDAC4 HDAC2 RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 AMER1 NPHP4 GSK3B CSNK1A1 AXIN1 APC OPN1SW CDC73 LEO1 HHAT SHH DHH ATF1 CREBBP IRAK4 SP1 MAPKAPK3 BCL2 AREG BCL2L1 MYOG PTPN6 MYOD1 TACR2 MYF6 TACR3 TCF4 TAC3 TACR1 MYF5 TAC1 CAMK4 HHIP NTF4 S100B NTRK2 DISP2 SAA1 BDNF ULK3 SCUBE2 TAB3 DZIP1 TGFA TAB2 FOS SPOPL FOXO3 ELK1 PTK2 EREG UHMK1 BTC MC2R EPGN AKT3 JUN FZD7 WNT5A ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SPPL2B SPPL2A CX3CR1 ATP2A3 CLIP3 NSMAF ATP2A2 ATP2A1 PRKG2 OPN3 RRH PTGIR RGR PLA2G4A OPN5 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 RXFP2 RXFP3 CRHBP PDE11A CMKLR1 PDYN AGTR2 FPR3 GALR3 GALR2 NOS3 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 PTH1R UCN3 UCN2 GPR37 PDE10A GPR35 GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR CDC14A MTNR1A MTNR1B RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 INSL5 PTH2 APLN GPR37L1 TAS2R19 KEL TAS2R42 HGS TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH MAS1 XK MC5R NPY2R NPY1R APLNR SUCNR1 HCAR2 HCAR3 WNT6 HCAR1 WNT2 PTCH2 PYY TAS2R9 WNT2B HEBP1 ADGRE1 GRM3 ADGRE2 GRM2 GRM7 GRM6 GPER1 GRM8 NPY5R DUSP4 SSTR1 DUSP3 SSTR2 VRK3 WNT16 DUSP6 SSTR4 DUSP7 SSTR5 CORT MAPK7 NPY4R OPRL1 PTHLH CNR2 CNR1 PIP5K1A TSHR PIP5K1B ACKR1 GOLGA7 ZDHHC9 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR TRRAP CCP110 AGT AR CFTR GATA3 SNX3 RHOT1 CSNK1G2 RCE1 ZRANB1 STAM CYLD OTUD7B RAB4A IKBKG RIPK2 UCHL5 KAT2B PIK3CD KAT2A NEDD8 USP9X USP17L2 RNF146 YY1 RUVBL1 MAP3K7 USP8 CER1 USP7 USP4 USP2 STAM2 VCP TNKS ADRB2 FOXO4 RIPK1 SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MDM2 TAB1 USP34 PTEN TNFAIP3 ARRB1 RGL1 ARRB2 TRAF2 AXIN2 TRAF6 BIRC2 BIRC3 USP13 USP15 TNKS2 USP21 OTUD3 CKB GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PPP1R1B PDE3A CCL4L2 HNRNPM RGS8 SNW1 PDE8B PDE8A PCP2 HNRNPF GRK3 GRK6 GPSM1 GPSM2 PDE4A GPSM3 PDE4D PDE4C RGS14 RGS20 RGS22 RGS10 RGS12 PDE7B PDE7A HNRNPH1 MEMO1 CTNND1 AMH NOG CTNNA1 PPP1CA SNAI1 PPP1CB TERT USF1 DDX5 CCR5 CXCR4 NPFFR2 OXTR NPFFR1 RGSL1 GRPR EDNRA EDNRB PROK2 PROK1 UTS2R NPFF TRHR UTS2B AGTR1 FPR2 LPAR4 HCRT YBX1 NTSR1 PTBP1 NTSR2 GPR17 NMB XCR1 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GCGR GPR4 GCG MT-RNR2 F2RL1 F2RL2 F2RL3 GPR68 GPR65 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 QRFPR GNRHR2 MMP3 XCL2 XCL1 RGS18 KIT RGS17 HTR2B RGS19 HTR2C RGS13 ADRB1 RGS16 P2RY6 ADRA1D HTR2A P2RY2 P2RY1 ADRA1B HTR4 RGS21 CCK ADRA1A HCRTR2 HRH1 HTR6 HCRTR1 TAAR3P KISS1 HTR7 HRH3 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 COL6A2 ADRA2C HTR5A ADRA2B COL4A4 TAAR1 COL6A1 ADRA2A GPR143 COL4A3 ADRB3 ATF2 COL6A3 RBPJ COL4A5 COL6A6 COL6A5 MEF2C B4GALT1 SPINT1 HPN SPINT2 HGFAC POGLUT1 POFUT1 MYL9 VPS29 VPS35 WLS VPS26A TMED5 TLE5 SFN COL1A2 EZH2 HEY1 CASP10 HEY2 MYLK HELLS KLF16 PPARG PPARD SPP1 RICTOR MBD3 STAT1 GATAD2B GATAD2A SKI CCNT2 CDC25C PRDM4 BEX3 CFLAR MAPKAPK5 KMT2B FOXO6 FOXO1 SOCS3 ACVRL1 BMPR2 AMHR2 GDF2 TNFRSF10B SMAD9 TNFRSF10A SMAD5 GREM2 ZFYVE16 BMPR1B NFKB1 BMPR1A TNFRSF10D PIN1 FASLG E2F4 E2F5 SST IL2RA STUB1 TRIM33 CCNK CCNC THBS2 GALNT3 MUC20 SH3GL3 EPS15 SH3GL2 SH3GL1 WWTR1 YES1 SMARCA4 SYVN1 CLTB YAP1 WNT5B ROR1 ROR2 PRICKLE1 RELA WNT1 FZD1 RYK FZD8 RHOT2 RXRG ARPC1B ARPC1A MFN1 MFN2 RHOBTB3 ITCH KLC1 GPAM KLC4 KLC3 KLC2 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH NF2 ACTR3 PRDM1 ACTR2 NR3C1 PPP1R12B PPP1R14A MYO19 PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 TRAK1 TRAK2 RAB9A RAB9B KIF5B IRAK1 KIF5A NCKIPSD RAP1GDS1 KDM4C IL2 IL3 IL6 BMP2 TCF3 YWHAE PRR5 LEP DPY30 CHD4 YWHAQ YWHAG YWHAH TGIF1 TBP TGIF2 EED STK4 SAV1 STK3 MOB1B MTA2 LATS1 MOB1A LATS2 AMOTL2 PENK AMOTL1 REST CARM1 KRAS CHRDL1 MMP2 MAML2 MAML1 VGF PIP4K2A PIP4K2B PIP4K2C JUNB RNF111 MED1 PRKCB FSTL1 FSTL3 PRKCQ MAML3 NOTUM CRKL MAPKAP1 NEDD4L SORCS3 CGA C3AR1 C5AR2 C5AR1 C5 RET RARG CD19 ASH2L GLI3 GLI2 RSPO3 CD55 TCF12 RARB CDKN2B WWP1 PTPN18 PF4 PTPN12 CSF2 PTPN7 PTPN2 MEN1 MST1 PGR MST1R FKBP5 ABL1 FPR1 SKIL CDK8 TIMP2 CDK5 WDR5 CRH HDAC5 HDAC8 HDAC9 HDAC6 HDAC7 GPR84 RAB6A RBBP4 RBBP5 RAB4B RBBP7 PML HDAC10 HDAC11 SOX2 SOX9 RUNX3 CITED1 PARP1 PRMT1 SGK1 PTPRJ NPY TJP1 FAS CDK5R1 ATP1B4 KCTD6 CXCR1 CBX6 CXCR2 SMURF1 SMAD6 ESR2 NR4A1 NR2E1 CASP2 OPRM1 RBL1 THBS1 ERBB2 HES1 OPRK1 POMC CXCL1 BAX PHB1 ARAF PEBP1 ADGRE5 CSK JAK2 ADGRE3 MARK3 FGB BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 TNS4 TNS3 SYK LCK FYN F2 DBT DLD CLTC CXCL6 CXCL9 CLTA CXCL8 CXCL13 AP2A1 CXCL3 CXCL2 AP2A2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 AP2M1 CCR8 CCR7 CCR4 CCR3 CCL13 CCL11 CCL3L3 CXCR5 CXCR6 CCL7 CCL5 CXCR3 CCL4 CCL3 CCL2 CCL1 CCL19 CCL17 CCL16 CCR10 CCL25 CCR1 AP2S1 CCL22 CCL21 CCL20 CXCL10 CXCL11 CXCL12 ACKR4 ACKR3 ACKR2 AP2B1 CCL28 CCL27 P4HB POU2F1 STAT5A PXN FLNA GLI1 GRAP2 SUFU BTRC NUMB MTA1 MTA3 PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX PPP3CA PPP3CB GNAT2 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD2 FZD5 FZD4 PDE6G FZD6 NFATC1 GNAO1 NAB1 NAB2 LYL1 F3 DNM2 ARC TRIB1 TPH1 RRAD ASCL1 EGR1 EGR2 EGR3 JUND EGR4 FOSL1 ID2 ID1 ID4 FOSB ID3 CDK5R2 TGFBR3 LRIG1 SOCS6 SH2B3 IKBKE BAG4 MATK GIPC1 ANOS1 WNT3A OFD1 LRP5 KREMEN1 WNT9A KREMEN2 DKK1 DKK2 LRP6 DKK4 SFRP1 CSNK1E SFRP2 WIF1 SOST IRS4 IGF1R CILP KDM4B DNER TLE4 TLE2 TLE1 DTX1 DTX2 DLK1 CNTN1 OPN1LW CGN F11R PRKCZ PARD3 SMC1A SMC3 STAG1 STAG2 RAD21 NRG3 NRG4 NRG2 H3-4 ARL13B PDE6D FABP5 FABP7 PLIN3 MGLL GGA3 PDK4 RASGRP3 PIK3AP1 IL5RA CSF2RB CSF2RA STAT5B NCOA2 IL5 IL3RA IL2RB NCOA3 GRB2 NR5A2 CTBP2 CTBP1 DNMT1 PPP5C TNF WNT10B STAT6 PDGFRB FOXA1 ZDHHC7 TLE3 PPID CAV2 GREB1 CHD1 MMP7 TFF3 TFF1 ZDHHC21 CXXC5 USF2 ZNF217 EBAG9 SMPD3 SMPD2 PSAP GSK3A NTRK1 KIDINS220 CRK UBE2L3 TNFSF10 FADD PPP3CC C1QBP SPTAN1 BCAP31 TJP2 FNTA OTULIN TRADD CASP8 FLOT1 FLOT2 DSP DSG1 UACA GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 DNM1 TMED2 FCER2 RFNG MFNG MDK ACTA2 LINGO1 MAG OMG RTN4 GPC5 ADCYAP1 ADCYAP1R1 SHC2 SHC3 RALGDS DNAL4 DNM3 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 UCN CRHR2 TSHB LYN PIK3CG PIK3R6 PIK3R5 BTK RALA CFL1 JAK1 TYK2 AAMP MKNK1 SPRY2 ALK AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ITGA3 GIP FFAR1 GNAZ ADORA2B JAG2 ADAM17 RDH5 CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 FAM135A VANGL2 ARHGAP8 SNAI2 OSBPL11 LRRC1 RRAS2 CIT PKN3 FGD5 CHN2 STX5 FARP2 PTPRU WWP2 WDR11 SH2B2 LETM1 CMA1 TMEM59 FER TEC VMA22 GRAP GOPC FILIP1 PKN2 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 RNF43 ZNRF3 FAM91A1 RSPO2 TEX2 RSPO1 ARMCX3 LGR6 PKP4 LGR5 RASAL2 KLB RSPO4 STIP1 LGR4 DDRGK1 FLT3 PLXNA1 IRS1 ANKRD26 PDE3B IRS2 NSFL1C CPD PIK3CB PLXNB1 TCIRG1 ARHGAP11A IDE FGF1 ZNF512B FGF2 CAPZB FGF3 EFHD2 NCK2 PTPRF FGF4 WDR6 FGF6 NCK1 FGF7 DST FGF9 PLEKHG6 AKT2 NIPSNAP2 BLTP3B GRB10 ATP6V1E1 PARD6B SH3BP1 CTSD WHAMM ATP6V1E2 HRAS WASF3 ATP6V1G1 NDUFA5 PCDH7 ATP6V0B ATP6V0E1 SEMA4F ATP6V1G2 PTPN13 ATP6AP1 VAPB PDPK1 GOLGA3 GAB1 BAIAP2L2 KCTD13 FLT3LG FRS2 TMEM87A GRB7 GAB2 PIK3CA PIK3R3 ATP6V1B2 SCFD1 SPTBN1 TLR9 EPO EPOR PIK3C3 CCDC88A TRIB3 FRAT1 ANLN FRAT2 ATP6V0D1 FAF2 KIF14 SOS1 SH3RF1 ATP6V0C AKAP12 ATP6V0D2 ATP6V1B1 GFAP HINT2 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 RHOH PIK3R1 RHOF INS RHOJ NRAS RHOU ATP6V0A2 RHOV FGF20 RHOQ THEM4 SAMM50 EMC3 ATP6V1H MTX1 MAPK1 ATP6V0A4 CAVIN1 MYO9A ATP6V0E2 ATP6V1G3 TRIP10 FGF23 RTKN PRAG1 ATP6V1D FGF22 SYDE2 ATP6V1C1 BASP1 ALDH3A2 ATP6V1F ATP6V1C2 ELMO2 DDX4 ATP6V0A1 MAPK3 ARHGEF28 PTPN1 ARHGAP19 INSR ARHGAP18 TOR1AIP1 PTPN11 FGF16 ARHGAP12 PLD2 FGF19 RHPN1 FGF18 RHPN2 FGFR4 FGF10 FAM83B ACBD5 MACO1 SHARPIN ARHGAP28 ARHGAP25 ARHGAP23 DIAPH2 UBXN11 CAMK2B DLG5 PICALM CAMK2D SRC DOCK5 ACTN2 DOCK4 ABCD3 CAMK2A NRG1 DOCK3 SOWAHC GRIN2B MTR TNFAIP1 RND2 GRIN2D GRIN1 RND3 RND1 DLG1 CKAP4 DLG2 SENP1 ZAP70 DLG3 GFOD1 LRRC7 ALS2 DLG4 NEFL PEAK1 CALM1 NDUFS3 DOCK2 CAMK2G DOCK1 CCDC187 IER3 MECOM MOSPD2 FAM169A PHLPP2 ADD3 PLK1 PHLPP1 PTK2B CD86 UBE2D1 CD80 HSPE1 ATN1 SLC4A7 ACTC1 SALL4 MAF1 PDHB TRAT1 RPS6KB2 CDK1 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 GLP1R VIPR1 VIPR2 RANBP9 SCT KAT5 GIPR GHRHR CHEK1 GLP2R SCTR GHRH VIP OPTN PPP1R12A SEM1 APP HGF CLIP1 PDGFB KNG1 IGF2 IGF1 CCR6 PPBP CCR2 TIMP1 S100A9 S100A8 PLG PLPPR1 PLPPR2 PLPPR3 ELANE PLPPR4 PLPPR5 LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PDGFRA GTF2A1 GTF2A2 BMP10 LTBP4 P2RY12 P2RY13 P2RY14 P2RY4 LTBP3 ADORA3 ADORA1 LTBP1 SCD FASN ITGB8 ULK1 TCF7L2 CDKN1A TCF7L1 HDAC1 LEF1 TCF7 FLRT3 CCND1 SIN3A CDK2 CTNNB1 MET PPP1R15A PTPRA SPTB TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB HSPB1 PSMD8 PSMD6 PSMD7 SPTBN4 XPO1 SPTBN5 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 ARTN PRKCD PRKCA GFRA1 YWHAZ GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 PSMA4 GFRA4 PSMA1 PSMA2 MAPKAPK2 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 CASP9 MMP14 MMP16 CASP3 XIAP C3 DHRS4 FURIN PCSK6 NGF PCSK5 IL1RL1 IL33 RNF20 SPEN IFT172 CCT2 IFT52 CPSF7 ROCK1 IFT57 ROCK2 DYNC2H1 IFT140 GPS1 ADAM12 RPGRIP1L CUL3 TXNL1 KIF7 WDR35 RHOBTB1 SRRM1 IFT88 SMO COPS4 TRA2B GPR161 COPS2 INTU TULP3 MYO6 STK38 KIF3A TTC21B PDE5A RBBP6 PTCH1 WDR19 VIM HNRNPC IFT122 FUZ CCT7 ADCY10 RBMX MKS1 DBN1 DTX4 TBK1 ELMO1 CD28 OPN1MW RASGRF1 RNF31 SPATA2 TNFRSF1A LIN7B OTUD1 TRIM27 HSP90AA1 NEDD4 MKRN1 EGF FRK CBL EGFR CDC37 PLCG1 CDKN1B CCND3 FNTB E2F1 RHO E2F3 GNAT1 TFDP1 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L PELP1 H2BC21 DOK1 MYB EP300 SFPQ IL6R RASA1 KHDRBS1 H3-3B KHDRBS2 H3C8 KHDRBS3 H2AC8 H2AC6 STAP2 H2AC7 SRMS BCAR1 H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RARA CBFB H3C15 RXRA H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CETP KDM3A HDAC3 KDM1A KDM1B GNAT3 GPS2 RXRB NRIP1 APOD GABRG3 UGT1A3 APOE GABRG2 TBL1X PCK1 NCOA1 ABCA1 ABCG8 KDM4A MYLIP ABCG5 NR1H2 APOC4 GABRB3 NR1H3 GABRB2 NCOR2 ARL4C GABRB1 EEPD1 NCOR1 TBL1XR1 FABP6 APOC2 APOC1 ANGPTL3 PLIN1 ABCG1 GNAI3 GNAI1 GNAI2 GABRQ GABBR2 GABRA1 GABBR1 ST3GAL4 ST3GAL6 AVP ST3GAL3 MEF2D TAS2R20 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1 NKX2-5 KAT2B WWTR1 TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 CCN2 HIPK2 TBX5 GATA4 NPPA ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 ITGB4 COL15A1 ITGA6 PLEC COL11A1 COL11A2 LOX COL10A1 COL27A1 COL24A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 COL6A3 BMP1 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 CTSS TLL2 TLL1 LAMB3 LAMA3 LAMC2 COL1A1 COL1A2 MMP9 PXDN MMP3 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD ABCD1 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 95%9748787 Azathioprine ADME ABCC5 GSTA2 NUDT15 IMPDH1 HPRT1 IMPDH2 GMPS GSTA1 SLC28A2 RAC1 SLC29A1 TPMT VAV3 NME1 ABCC4 SLC29A2 SLC28A3 GSTM1 NME2 XDH VAV1 VAV2 GUK1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination YAP1 CYP51A1 POU3F1 MPZ SREBF2 ADGRG6 LAMA2 DRP2 HMGCR PRX LAMB1 LAMC1 PMP22 SOX10 NAB1 NAB2 UTRN EGR2 DAG1 POU3F2 MAG HDAC2 TEAD1 WWTR1 SMARCA4 SCD5 MBP ADGRV1 INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%3232142 SUMOylation of ubiquitinylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 TRIM27 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 PML UBE2I PIAS1 SUMO1 MDM2 NUP205 POM121 NUP107 NUP188 AAAS VHL NUP160 NUP214 POM121C NUP42 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ1 KCNJ16 KCNJ10 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR5AL1 OR8H3 OR8H2 OR8H1 OR52M1 GNAL OR10V1 ADCY3 OR4C12 OR2AT4 OR6C6 OR4C11 OR6C4 OR1F12P OR5A2 OR4C16 OR6C3 OR8G5 OR5A1 OR4C15 OR5AK2 OR6C2 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR6B3 OR7D4 OR6B2 OR7D2 OR6B1 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 CNGA2 OR9G9 CNGA4 OR4D11 OR4D10 OR2A12 OR2Z1 LDB1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR4E2 OR5G3 OR4E1 OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR5B17 OR4D5 OR4D2 OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR4A15 OR4C3 OR14A2 OR3A2 OR4A16 OR3A1 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4B1 OR4C46 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR5C1 OR7G3 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR2D3 OR52A4P OR1B1 OR2D2 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR1A2 OR2C3 OR6K6 OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR5H6 OR4F5 OR2B3 OR4F4 OR2B2 OR10K2 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 OR52J3 RTP2 OR51H1 RTP1 OR8U9 OR8U8 OR1G1 OR2I1 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR51G1 OR52I2 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR10Q1 OR6P1 OR2AP1 OR2B11 OR51F2 OR5M9 OR51F1 OR2G6 OR52H1 OR5M8 OR1E3 OR4K5 OR2G3 OR1E2 OR2G2 OR1E1 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR2T34 OR8S1 OR2T35 OR2T33 OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR1D2 OR2F2 OR2F1 OR2T29 OR5L2 OR51E2 OR5L1 OR6N2 OR6N1 OR4F17 OR4F15 GNG13 GNB1 LHX2 OR11H2 OR11H1 OR11H4 OR2M7 OR2M5 OR2M4 OR2M3 ANO2 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR2L5 OR11G2 OR1J2 OR2L3 OR4P4 OR1J1 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR2K2 OR1I1 OR6S1 OR5M11 OR5M10 OR10D3 OR8B12 OR14K1 OR2J3 OR4N5 OR2J2 OR4N4 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR10G2 OR14A16 OR1L8 OR10G4 OR10G3 OR1L6 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR4A4P OR5AS1 OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR13C9 OR2T2 OR13C8 OR2T1 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 OR51S1 OR4A47 OR5B21 OR1P1 REEP1 OR13A1 OR8G2P OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR52Z1P OR13G1 OR6C74 OR14I1 OR10A7 OR56A5 OR7A5 OR10A2 OR56A4 OR10A4 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR13F1 OR6C68 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 EBF1 OR2V1 OR8A1 OR11A1 OR7G2 OR8I2 OR7G1 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR5D13 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 95%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2BC9 METTL23 H4C9 H2BC8 H2BC26 H2BC5 H2BC3 H2BC12L H2BC21 NPM2 H2BC1 H3-3B SRPK1 H1-8 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 HIRA H2AX PRM2 PRM1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 95%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG ARF1 RALA RPLP0 PITPNA BOLA2B RAP1B CNN2 HNRNPDL CFL1 LMNB1 STAT4 HNRNPA2B1 SOD2 TCP1 CA1 HSPA9 IL10 SERPINB2 ANXA2 GSTO1 CDC42 AIP MSN TALDO1 MIF SOD1 MTAP GSTA2 CAPZA1 PDCD4 HNRNPF PSME2 LCP1 PPIA SNRPA1 PAK2 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9615710 Late endosomal microautophagy CETN1 PARK7 RNASE1 CHMP3 CFTR CHMP6 CHMP7 UBA52 ARL13B HBB HDAC6 PLIN2 IFT88 UBB UBC RPS27A PLIN3 CHMP4C CHMP4B VPS28 TSG101 HSPA8 CHMP4A VPS37C VPS37D VPS37A VPS37B CHMP2B MVB12B PCNT CHMP2A MVB12A UBAP1 PI3K AKT SIGNALING IN CANCER%REACTOME DATABASE ID RELEASE 95%2219528 PI3K AKT Signaling in Cancer NTRK3 NTF3 PDGFB RICTOR FOXO4 ESR1 MDM2 CD28 PRR5 PTEN GSK3A EGF EGFR CDKN1B KLB FLT3 IRS1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 PDGFRA RAC1 PDPK1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 MAPKAP1 HBEGF RAC2 RHOG PIK3R2 PIK3R1 CDKN1A FGF20 FGF23 FGF22 CHUK MET BAD PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 MLST8 TSC2 ESR2 SRC NR4A1 MTOR NRG1 AKT1S1 AKT1 PIK3AP1 GSK3B CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 RPS6KB2 PIK3R5 STRN PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA FOXO3 HGF EREG CASP9 BTC EPGN AKT3 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation EIF2S2 EIF2S1 EIF2S3 EIF4E EIF4B EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PABPC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 EIF4G1 RPS20 FAU RPS21 RPS24 RPS27 RPS23 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA3 UBA52 PSMD12 PSMD11 UBE2M PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 CHUK PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RELB FBXW11 ADRM1 MAP3K14 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 CUL1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 95%196791 Vitamin D (calciferol) metabolism CYP27B1 GC PIAS4 CYP24A1 CYP2R1 LRP2 SUMO2 LGMN UBE2I VDR LDLRAP1 CUBN MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%164516 Minus-strand DNA synthesis PPIA HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair PCNA ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 PARP1 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MDC1 FEN1 SUMO2 UBE2I PIAS4 BRCC3 UBA52 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 UBC RFC5 RMI2 RFC3 RFC4 RPS27A RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C RPA3 RAD17 CCNA2 RAD1 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A POLQ GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism GALK1 PGM1 GALE GALM GALT AKR1B1 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 95%113507 E2F-enabled inhibition of pre-replication complex formation ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CCNB1 CDK1 ORC5 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 95%186797 Signaling by PDGF COL4A2 COL4A1 SOS1 FURIN STAT3 PIK3R2 PIK3R1 PDGFB NRAS SPP1 COL6A2 COL4A4 COL6A1 COL4A3 STAT1 PTPN11 COL6A3 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 SRC PLG CRK STAT5A STAT5B THBS1 PLCG1 THBS2 PDGFD PTPN12 PIK3CB RAPGEF1 PLAT NCK2 NCK1 THBS4 RASA1 THBS3 PDGFRA HRAS BCAR1 STAT6 PDGFRB GRB7 CRKL PIK3CA ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%1369062 ABC transporters in lipid homeostasis PEX3 ABCA10 ABCG4 ABCA3 ABCD2 ABCA6 ABCA2 ABCA5 ABCG1 ABCA9 ABCD3 ABCA7 APOA1 ABCD1 ABCA12 ABCG8 PEX19 ABCG5 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 ADCY9 GNB4 GABBR2 GNAL GNB3 ADCY4 KCNJ5 ADCY3 GNB5 ADCY2 KCNJ6 ADCY1 GABBR1 ADCY8 KCNJ10 ADCY7 GNGT1 ADCY6 KCNJ12 ADCY5 KCNJ9 GNGT2 GNAT3 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 CRISTAE FORMATION%REACTOME%R-HSA-8949613.3 Cristae formation ATP5PB ATP5F1C ATP5F1D MT-ATP8 ATP5F1E ATP5PO SAMM50 MTX1 APOOL CHCHD3 DMAC2L HSPA9 ATP5MC2 ATP5MC3 ATP5MK ATP5MJ MICOS13 MT-ATP6 MICOS10 ATP5MC1 CHCHD6 ATP5MG ATP5MF ATP5ME APOO DNAJC11 IMMT TMEM11 ATP5F1A ATP5F1B ATP5PF MTX2 ATP5PD WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.2 WNT5A-dependent internalization of FZD4 CLTC CLTB PRKCA FZD4 WNT5A AP2S1 CLTA AP2A1 AP2A2 AP2B1 AP2M1 PRKCB DVL2 PRKCG ARRB2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.8 Asparagine N-linked glycosylation KDELR1 SEL1L RNF185 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 MGAT3 KDELR2 SAR1B COPB2 COPA TMED10 B4GALT6 DERL1 B4GALT5 DERL2 MAN2A2 SERPINA1 RNF5 OS9 COPE ARF4 MAN1A2 F5 TMED3 F8 MAN1A1 TMED7 TMED9 COPZ2 BET1L COPZ1 USO1 ARF5 NAPA GBF1 NAPB SPTAN1 RAB1A RAB1B GOSR1 GOLGA2 NAPG MIA3 CHST10 MAN1C1 GORASP1 B4GALNT2 ARCN1 COPG2 COPG1 B4GALT2 B4GALT3 B4GALT4 CGA RPN2 TUSC3 PRKCSH DCTN6 RPN1 DCTN5 DCTN1 MAGT1 DCTN4 FUT8 GANAB MAN2A1 MGAT5 CAPZA3 MGAT1 MGAT2 CAPZA2 COL7A1 OST4 EDEM2 ACTR10 MOGS ARF3 SEC31A DDOST MGAT4C TMEM258 DAD1 OSTC TMED2 MGAT4A CALR CANX SPTB MGAT4B STT3A STT3B B4GALT1 MAN1B1 ANK2 ANK3 CD59 CD55 SPTBN4 SPTBN5 SPTBN2 ASGR1 ASGR2 UBA52 ACTR1A ARF1 SPTA1 PDIA3 CSNK1D UBB UBC RPS27A CAPZA1 DCTN2 DCTN3 UMOD LMAN1 GOSR2 PSMC1 YKT6 ARFGAP1 PREB SRD5A3 KDELR3 VCP FUCA1 TRAPPC4 SEC22B LHB SEC23A SEC24B GLB1 SEC24A STX5 RAD23B ANKRD28 SEC13 PPP6C PPP6R3 SEC24D SEC24C TRAPPC1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 CTSZ DYNLL2 NSF CTSC DYNC1I2 DYNC1I1 DYNC1H1 GRIA1 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT TFG GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 COPB1 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS GOLGB1 DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 ANK1 SLC17A5 ST8SIA5 AREG ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 UBXN1 ST8SIA2 NGLY1 RNF139 GFPT2 MLEC PMM2 TGFA ST8SIA3 UGGT2 GFPT1 UGGT1 MARCHF6 DOLK EDEM3 NAGK EDEM1 FCSK AMFR DOLPP1 SYVN1 RNF103 TRIM13 ENGASE INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 95%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC16 ANAPC7 UBE2C BUB3 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BUB1B CDC20 MAD2L1 ANAPC15 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%111457 Release of apoptotic factors from the mitochondria BAX CYCS BAK1 GSDMD DIABLO GSDME DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 95%9665737 Drug resistance in ERBB2 TMD JMD mutants ERBIN HSP90AA1 ERBB2 CDC37 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation ITGA5 FN1 ITGB1 CEACAM1 CEACAM6 CEACAM8 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 95%2024096 HS-GAG degradation SGSH AGRN NAGLU GPC1 GPC3 GPC2 GPC5 GPC4 IDUA GPC6 HSPG2 SDC1 CTSL HPSE SDC4 HPSE2 SDC2 SDC3 IDS UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.2 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes ACSS3 AGPAT2 ABL1 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 DPY30 WDR5 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 PAXIP1 PEX11A AJUBA PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 CREBBP MED17 MED12 MED14 MED13 MED10 PAGR1 MED27 KDM6A SIRT1 MED23 MED24 MED20 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 95%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 AURKB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 RB1 PSMD12 CDC16 PSMD11 AURKA ANAPC4 ANAPC5 PSMD14 FZR1 ANAPC1 ANAPC2 PSMD13 PSMA7 SKP2 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%139915 Activation of PUMA and translocation to mitochondria E2F1 BBC3 TP63 TP73 PPP1R13B TP53 TFDP1 TFDP2 TP53BP2 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GUSB ARSB GYG1 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 ALDOB EPM2A DCXR GNS SI PPP1R3C LCT HGSNAT NHLRC1 GAA G6PC3 UBB SGSH UBC TALDO1 KHK RPS27A GALNS NAGLU SLC37A4 RPIA IDUA HYAL1 GLB1 IDS SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 95%9820448 Developmental Cell Lineages of the Exocrine Pancreas FGF10 LAMA5 FGF2 LAMA2 LAMB3 LAMC3 EGF FGF4 LAMB2 LAMA1 FGF7 LAMA4 LAMA3 FN1 LAMB1 LAMC2 LAMC1 VTN VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 FLT4 KDR VEGFB VEGFC VEGFD PGF VEGFA HIV INFECTION%REACTOME DATABASE ID RELEASE 95%162906 HIV Infection AP2A1 AP2A2 NPM1 AP2M1 CCR5 CXCR4 AP2S1 AP2B1 TAF4B TBP TAF9 TAF1L NMT1 BTRC TAF15 TAF12 TAF13 TAF11 TAF8 KPNB1 TAF7 TAF6 CD4 TAF5 TAF4 TAF3 TAF2 TAF1 CHMP4C CHMP4B CHMP4A RAC1 GTF2A1 CHMP2B GTF2A2 GTF2B CHMP2A GTF2E1 GTF2E2 PDCD6IP NEDD4L CHMP3 CHMP6 CHMP7 TAF7L FEN1 PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 RNMT CCNH PSMA5 PSMA6 POLR2A PSMA3 POLR2B PSMA4 POLR2C PSMA1 POLR2D POLR2E RAN PSMA2 POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J ARF1 PSMD12 POLR2K PSMD11 POLR2L RNGTT GTF2H1 PSMD14 GTF2H2 GTF2H3 PSMD13 SUPT5H PSMA7 GTF2F1 GTF2H4 PSMB6 GTF2F2 GTF2H5 PSMB7 CDK7 ERCC3 PSMB4 ERCC2 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A CUL5 ADRM1 PPIA PSMC5 PSMC6 PSMC3 TAF9B PSMC4 PSMC1 PSMC2 PAK2 FURIN AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 NMT2 LIG1 RCC1 TAF10 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 XRCC6 XRCC4 XRCC5 LIG4 RANGAP1 ATP6V1H DOCK2 CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 HCK SEM1 LCK FYN SKP1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 95%9662361 Sensory processing of sound by outer hair cells of the cochlea ESPNL EPB41L3 OTOG CDH23 XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 OTOGL TMIE USH1G STRC MYO15A SLC26A5 EPB41L1 KCNMA1 KCNMB1 CASK KCNQ4 SPTAN1 CHRNA9 CHRNA10 KCNN2 GSN MSN MYO1C CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 PLS1 TPRN TMC1 MYO7A MYH9 TMC2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 USH1C SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427652 Sodium-coupled phosphate cotransporters SLC17A1 SLC20A2 SLC34A3 SLC34A2 SLC20A1 SLC34A1 HCMV LATE EVENTS%REACTOME%R-HSA-9610379.4 HCMV Late Events H2BC9 CHMP3 H4C9 H2BC8 CHMP6 H2BC5 CHMP7 H2BC3 H2BC1 H2AC20 H2AC1 HNRNPK H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 H2BC18 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 NUP37 VPS36 VPS25 SNF8 CHMP1A H2AC19 H2BC26 H2AC14 CHMP4C H2BC21 CHMP4B VPS28 CHMP4A TSG101 VPS37C H3C8 VPS37D H2AC8 VPS37A H2AC6 VPS37B H2AC7 CEBPD H2BC17 VPS4A CHMP2B H2BC12 MVB12B CHMP2A H2BC13 MVB12A H2BC14 UBAP1 H2BC15 H2BC11 H3C15 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%6807878 COPI-mediated anterograde transport KDELR1 KDELR3 DYNLL1 FOLR1 INS BET1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 COG8 COG7 COG6 NSF COG5 COG4 COG3 CAPZA3 COG2 COG1 CAPZA2 DYNC1I2 ACTR10 ARF3 KDELR2 COPB2 COPA TMED10 TMED2 SPTB DYNC1I1 DYNC1H1 COPE ARF4 ANK2 ANK3 CD59 CD55 SPTBN4 TMED3 SPTBN5 SPTBN2 TMED7 TMED9 COPZ2 COPB1 BET1L STX5 COPZ1 USO1 ACTR1A ARF1 ARF5 GOLGB1 NAPA GBF1 NAPB SPTAN1 SPTA1 RAB1A RAB1B GOSR1 GOLGA2 NAPG ARFGAP3 ARFGAP2 CAPZB DYNC1LI1 GORASP1 ANK1 DYNC1LI2 ARCN1 DCTN2 CAPZA1 DCTN3 COPG2 GOSR2 COPG1 YKT6 TMEM115 ARFGAP1 SPTBN1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654695 PI-3K cascade:FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF7 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 FGF16 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9840309 Glycosphingolipid biosynthesis B3GNT5 B4GALT6 B4GALT5 FUT2 FUT1 ST8SIA5 UGCG ST3GAL5 UGT8 ST3GAL2 ST3GAL3 B4GALNT1 GAL3ST1 CERK B3GALNT1 B3GALT4 ST6GALNAC5 ST6GALNAC6 A4GALT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A EIF4A2 RPS26 EIF4A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A EIF2S2 RPL36AL EIF2S1 RPL36 EIF2S3 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 EIF4E RPL13A EIF4B RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 EIF4H RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 PABPC1 UBA52 RPLP0 RPS27A EIF4G1 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 95%9007892 Interleukin-38 signaling IL1F10 MAPK8 IL1RAPL1 IL1RL2 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%71064 Lysine catabolism GCDH HYKK AADAT PIPOX SLC25A21 CRYM AASS DHTKD1 ALDH7A1 DLST PHYKPL DLD TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR2 ARRB1 ARRB2 TGFBR3 TGFB2 TGFB1 GIPC1 TGFBR1 SIGNALING BY FGFR IN DISEASE%REACTOME DATABASE ID RELEASE 95%1226099 Signaling by FGFR in disease SOS1 CEP43 STAT3 PIK3R1 ERLIN2 NRAS FGF20 FGF23 FGF22 STAT1 FGF16 FGF18 FGFR4 FGF10 ZMYM2 FGFR1OP2 POLR2A BAG4 POLR2B STAT5A STAT5B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TRIM24 PLCG1 POLR2I FGFR3 POLR2J POLR2K POLR2L GTF2F1 CPSF6 GTF2F2 FGFR1 MYO18A LRRFIP1 CUX1 BCR NCBP1 NCBP2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 HRAS GAB1 FRS2 GAB2 PIK3CA SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 95%166520 Signaling by NTRKs RPS6KA1 CLTC CLTA AP2A1 AP2A2 FURIN NTRK3 PCSK6 NTF3 NGF PCSK5 AP2M1 RAP1A AP2S1 CDK5 AP2B1 CHD4 NTRK1 KIDINS220 CRK PLCG1 REST IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB PTPRO VGF EP300 JUNB RAC1 HRAS GAB1 FRS2 MAP2K1 CRKL MAP2K2 PIK3CA TIAM1 SOS1 DUSP4 DUSP3 VRK3 PTPRS DUSP6 SHC1 PPP2R5D DUSP7 MAPK7 STAT3 PIK3R2 PIK3R1 NRAS SGK1 RHOA MAPK1 NAB1 NAB2 LYL1 DNM1 F3 DNM2 ARC SRF TRIB1 MAPK3 CDK5R1 TPH1 ATF2 RRAD ASCL1 PTPN11 EGR1 EGR2 EGR3 PPP2CA JUND PPP2CB EGR4 FOSL1 ID2 ID1 MEF2C ID4 FOSB ID3 CDK5R2 SRC ADCYAP1 ADCYAP1R1 YWHAB SHC2 DOCK3 SHC3 RALGDS GRIN2B DNAL4 DNM3 TCF12 ADORA2A RALB MAPK12 MAPK13 RIT1 RIT2 MAPKAPK2 RALA BAX ATF1 NELFB BRAF MAP2K5 RAPGEF1 MAPKAPK3 FRS3 SH3GL3 SH3GL2 MAPK14 MAPK11 MEF2D NTF4 NTRK2 BDNF FOS ELK1 MEF2A RPS6KA3 RPS6KA5 RPS6KA2 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 95%4687000 Defective MPDU1 causes CDG-1f MPDU1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 95%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 95%5679001 Defective ABCC2 causes DJS ABCC2 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 95%1433559 Regulation of KIT signaling PRKCA SOS1 SH2B2 LYN CBL PTPN6 YES1 LCK FYN KIT SOCS6 SH2B3 SOCS1 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 95%9034015 Signaling by NTRK3 (TRKC) PTPRO SOS1 PTPRS NTRK3 NTF3 PIK3R1 NRAS PLCG1 SRC BAX HRAS PIK3CA NELFB IRS1 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%425381 Bicarbonate transporters SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A7 SLC4A4 AHCYL2 SLC4A8 SLC4A9 SLC4A10 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 95%2408552 Methylation of MeSeH for excretion INMT RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.6 Recognition and association of DNA glycosylase with site containing an affected purine H2BC9 ACD H2AZ2 TINF2 H4C9 TERF1 H2BC8 TERF2 H2BC5 H2BC3 NEIL3 H3-4 H2BC1 POT1 TERF2IP H2AC20 MPG H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L OGG1 H2BC21 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 95%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPD SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 95%111465 Apoptotic cleavage of cellular proteins OCLN APC DSG1 DSG3 PLEC ADD1 BIRC2 ROCK1 SPTAN1 LMNB1 CTNNB1 DBNL TJP1 ACIN1 GAS2 MAPT BCAP31 VIM GSN CLSPN TJP2 FNTA DSG2 PKP1 CDH1 BMX SATB1 STK24 STK26 PRKCQ CASP8 CASP6 PTK2 CASP7 DSP CASP3 PRKCD TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 95%6803211 TP53 Regulates Transcription of Death Receptors and Ligands IGFBP3 TNFRSF10C TP63 TP73 PPP1R13B TNFRSF10B TNFRSF10A FAS TP53 TMEM219 TNFRSF10D TP53BP2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K VKORC1 VKORC1L1 UBIAD1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 95%9861559 PDH complex synthesizes acetyl-CoA from PYR DLAT PDHX PDHA2 PDHA1 PDHB DLD GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%982772 Growth hormone receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR LYN STAT3 SOCS3 ADAM17 PTPN6 MAPK1 JAK2 SOCS2 CISH STAT1 MAPK3 PTPN1 SOCS1 IRS1 IRS2 GH1 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 95%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) SEL1L ERLIN1 ERLIN2 RNF185 VCP PRKAA1 PRKAA2 PRKAG1 PRKAG2 PRKAG3 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRKAB2 PRKAB1 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion CACNA1D GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 ADCY6 CACNA1C ADCY5 GNGT2 ADRA2C ADRA2A CACNB3 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 GNAI1 CACNB2 GNAI2 GNG10 GNG12 GNG11 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA PRKCA ANP32A ELAVL1 XPO1 TNFSF13 NUP214 SET PRKCD REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0D1 ATP6V1G1 ATP6V0B ATP6V0C ASAH1 ATP6V0E1 ATP6V1A ATP6V1C1 ATP6V1B2 ATP6V1E1 ATP6V1H LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells UBC SH3KBP1 RPS27A SH3GL3 EPS15 CBL SH3GL2 CDH1 SH3GL1 CTNND1 UBA52 SRC STAM STAM2 CBLL1 CTNNB1 MET HGS UBB SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 95%372790 Signaling by GPCR FZD7 WNT5A TAS2R10 TAS2R13 WNT1 FZD1 TAS2R14 ADCY9 TAS2R16 FZD8 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CX3CR1 IHH AVPR1B OPN3 RRH TAS2R40 PTGIR RGR AVPR2 TAS2R41 TAS2R43 AVPR1A OPN5 PLA2G4A TAS2R46 PDE1B RXFP4 PDE1A MRGPRD ITPR1 FZD10 ITPR2 RXFP1 ITPR3 TAS2R30 RXFP2 TAS2R31 RXFP3 PSAP CRHBP TAS2R38 PDE11A CMKLR1 PDYN AGTR2 TAS2R39 FPR3 GALR3 GALR2 GALR1 NPBWR1 PDE2A NPBWR2 WNT10A FZD9 GPR183 PNOC GPR18 SSTR3 PTH1R UCN3 UCN2 GPR37 GPR35 PDE10A GPR31 PTH2R GPHA2 WNT7B GNAS GPR55 WNT7A GPHB5 LHCGR MTNR1A MTNR1B TAS2R50 MCHR1 RLN2 RLN3 ECE1 ECE2 PRLHR INSL3 PPP3CC INSL5 PTH2 PENK APLN GPR37L1 TAS2R19 KEL TAS2R42 TAS2R45 CRHR1 NLN PPY MC1R TAS2R60 MC4R OXGR1 GPBAR1 MC3R GAL FSHR NPB PTH NPW PRLH TRIO MAS1 RASGRF2 XK ITSN1 MC5R NPY2R ARHGEF10L NPY1R AKAP13 APLNR PREX1 SUCNR1 HCAR2 MCF2L PRKCB HCAR3 ARHGEF40 WNT6 VAV3 HCAR1 WNT2 ARHGEF11 PTCH2 ARHGEF10 PYY ARHGEF12 PLEKHG2 TAS2R9 PRKCQ WNT2B ARHGEF15 PLEKHG5 HEBP1 ADGRE1 ARHGEF17 GRM3 ARHGEF16 ADGRE2 ARHGEF19 GRM2 ARHGEF18 VAV1 GRM7 VAV2 GRM6 TIAM2 GPER1 TIAM1 GRM8 ARHGEF9 NPY5R OBSCN SSTR1 CGA ARHGEF3 SSTR2 ARHGEF4 WNT16 ARHGEF1 SSTR4 ARHGEF2 SSTR5 ARHGEF7 CORT MAPK7 SOS2 NPY4R C3AR1 ARHGEF5 OPRL1 NGEF PTHLH ARHGEF6 CNR2 ARHGEF26 CNR1 TSHR KALRN ACKR1 FGD1 FGD2 GNA13 FGD3 ABR FGD4 C5AR2 ECT2 C5AR1 ARHGEF33 ARHGEF35 C5 ARHGEF37 ARHGEF39 MCF2 ARHGEF38 NET1 PTGER4 PTGFR PTGER1 TAS2R7 TBXA2R PTGDR2 ADCYAP1 PTGER2 ADCYAP1R1 PTGER3 TAS2R8 PTGDR ADORA2A CD55 AGT UCN GRM4 TAS2R1 CRHR2 TAS2R3 TAS2R5 TAS2R4 TSHB PIK3CG PIK3R6 PIK3R5 BTK PF4 TAS1R2 TAS1R1 TAS1R3 RGS9 RGS6 RGS7 AHCYL1 PDE1C CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PRKCE NBEA GNG10 RPS6KA3 GNG12 RPS6KA2 GNG11 RPS6KA1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 FPR1 GNGT2 GIP FFAR1 ADRB2 GNAZ GNA14 LHB ADORA2B GNG3 CDK5 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 RGS11 ARRB1 ARRB2 CRH GPR84 WNT3 WNT8A WNT8B PPP2R1B PDE3B PPP2R1A PLXNB1 AKT2 HRAS PDPK1 PIK3CA PIK3R3 ITGB1 SOS1 PPP2R5D PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB NPY MAPK1 MAPK3 GPR176 GPR15 GPR27 GPR25 GPR20 CDC42 GPR32 PPP2CA GPR45 PPP2CB GPR150 GPR83 PPP1R1B PDE3A CXCR1 CCL4L2 CXCR2 RGS8 PDE8B PDE8A CAMK2B PCP2 GRK3 CAMK2D DGKG SRC GRK6 DGKE GPSM1 DAGLA GPSM2 CAMK2A DGKD PDE4A DGKB GPSM3 DGKA PDE4D ABHD6 PDE4C ABHD12 RGS14 PRKCH RGS20 DGKZ RGS22 DGKQ RGS10 DAGLB RGS12 DGKK PDE7B DGKI PDE7A DGKH OPRM1 CALM1 CAMK2G OPRK1 POMC CXCL1 PPP1CA GNA12 ADGRE5 ADGRE3 GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP WNT9B APP WNT4 F2 CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 KNG1 CCR7 CCR4 RASGRP2 CCR3 RASGRP1 CCL13 CCL11 CCL3L3 PRKACG CXCR5 CCR5 CXCR6 PRKACA CCL7 CXCR4 PRKACB CCL5 NPFFR2 CCR6 OXTR PPBP CXCR3 CCL4 NPFFR1 CCL3 RGSL1 GRPR CYSLTR1 CCL2 CCL1 EDNRA CCL19 EDNRB PROK2 CCL17 CCR2 PROK1 CCL16 UTS2R CCR10 CCL25 NPFF TRHR CCR1 CCL22 UTS2B AGTR1 CCL21 FPR2 CCL20 CXCL10 LPAR4 HCRT CXCL11 CXCL12 NTSR1 NTSR2 ACKR4 GPR17 ACKR3 NMB ACKR2 CCL28 XCR1 CCL27 NMBR LPAR6 NMS NMU GNRH2 GNRH1 QRFP TRPC7 MLN BRS3 GPRC6A GPR132 TRPC6 CCKAR TRPC3 GNRHR FFAR4 FFAR3 FFAR2 GAST GPR39 EDN1 ANXA1 EDN2 EDN3 PLCB4 CCKBR NPSR1 GRP PTAFR NPS PLPPR1 PROKR1 PLPPR2 PROKR2 PLPPR3 KISS1R PLPPR4 P2RY10 PLPPR5 P2RY11 LPAR1 GCGR GPR4 LPAR2 LPAR3 GCG LPAR5 MT-RNR2 CHRM2 F2RL1 S1PR1 CHRM3 F2RL2 S1PR3 CHRM1 F2RL3 S1PR2 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 PMCH RGS4 RGS5 RGS2 CYSLTR2 RGS3 RGS1 GHSR CASR F2R LTB4R2 UTS2 NTS MCHR2 GRK5 OPN4 NMUR2 NMUR1 MLNR OXT TRH LTB4R GRM1 GRM5 PRKAR1B BDKRB2 PRKAR2B BDKRB1 PRKAR1A QRFPR PRKAR2A GNRHR2 PRKX MMP3 XCL2 PPP3CA XCL1 PPP3CB GNAT2 RGS18 RGS17 PLCB3 HTR2B RGS19 PLCB1 HTR2C RGS13 PLCB2 ADRB1 RGS16 P2RY12 ADRA1D P2RY6 PPP3R1 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 WNT11 HTR4 P2RY4 RGS21 ADORA3 ADRA1A CCK FZD3 ADORA1 HCRTR2 HRH1 HTR6 FZD2 HCRTR1 FZD5 TAAR3P KISS1 HTR7 FZD4 HBEGF HRH3 FZD6 HRH2 HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 HTR1E TAAR8 HTR1F TAAR9 OPRD1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 ADRA2C FSHB HTR5A ADRA2B TAAR1 ADRA2A GPR143 ADRB3 AKT1 PRKCD PRKCA WNT3A WNT9A PAK1 C3 ROCK1 ROCK2 SMO PTCH1 OPN1LW OXER1 OPN1MW ARHGEF25 EGFR RHO GNAT1 RAMP2 CALCA RAMP3 CALCB CALCR CALCRL ADM2 ADM IAPP RAMP1 ITGA5 GNAT3 MGLL GNAI3 GNAI1 GNAI2 SST OPN1SW GABBR2 GABBR1 SHH DHH WNT10B AVP TACR2 TACR3 TAC3 TACR1 TAC1 TAS2R20 CAMK4 SAA1 MC2R AKT3 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants CEP43 STAT5A STAT5B STAT3 PIK3R1 TRIM24 ZMYM2 CPSF6 FGFR1OP2 GAB2 MYO18A STAT1 PIK3CA LRRFIP1 CUX1 BCR FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 95%2871809 FCERI mediated Ca+2 mobilization IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 TEC IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 VAV3 PPP3CA PPP3CB PPP3R1 VAV1 VAV2 SOS1 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CALM1 LYN BTK NFATC3 TXK SYK AHCYL1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 95%9857492 Protein lipoylation GCSH DLAT LIPT2 LIPT1 NDUFAB1 DLST FDX1 NFU1 DBT LIAS TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK RFC5 PCNA UBC RFC3 RFC4 POLK RPS27A RFC2 RFC1 RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 REV3L UBB RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 95%2995410 Nuclear Envelope (NE) Reassembly CHMP3 CHMP6 CHMP7 RANGAP1 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 PPP2CA TUBA3E TUBA3D TUBA3C UBE2I SUMO1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 TNPO1 NUP160 NUP85 NUP62 BANF1 SIRT2 NUP43 RAN NDC1 CCNB1 TUBB8 SEC13 NUP155 NUP133 IST1 VRK1 CDK1 LEMD2 NUP93 TUBB8B NUP35 EMD NUP54 LBR NUP37 KPNB1 SPAST CC2D1B LEMD3 PPP2R1A TUBB6 TUBB3 TUBB1 PPP2R2A CHMP4C RCC1 CHMP4B CHMP4A TUBA4B VPS4A CHMP2B TUBA4A CHMP2A CCNB2 AHCTF1 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME DATABASE ID RELEASE 95%9031528 LXRs regulate gene expression linked to triglyceride lipolysis in adipose RXRA NR1H2 NR1H3 RXRB PLIN1 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME%R-HSA-2691232.3 Constitutive Signaling by NOTCH1 HD Domain Mutants UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import PEX10 PEX12 PEX13 PEX14 SLC27A2 DHRS4 NUDT7 CRAT PECR ZFAND6 PEX26 SCP2 NUDT19 MPV17 ACAA1 GSTK1 PHYH ACOT8 ECH1 PIPOX GNPAT ACOT2 ACOT4 UBE2D2 UBE2D3 NOS2 HACL1 HAO1 DECR2 HAO2 EPHX2 IDH1 TYSND1 UBE2D1 AMACR DAO CAT CROT UBA52 PEX2 PEX1 BAAT PEX7 UBB ACOX2 ACOX1 IDE UBC EHHADH LONP2 PEX6 AGPS RPS27A ACOX3 AGXT PAOX HSD17B4 DDO HMGCL USP9X TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CPAP CNOT4 CNOT6 CNOT7 PLK3 CNOT1 CNOT2 CNOT3 NPM1 CDC25C RGCC PLAGL1 TNKS1BP1 CNOT10 PLK2 CNOT8 CNOT9 CNOT6L CNOT11 TP53 BTG2 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 95%168316 Assembly of Viral Components at the Budding Site CANX CALR INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9020558 Interleukin-2 signaling LCK JAK3 STAT5A STAT5B PTK2B SHC1 IL2RB JAK1 IL2RG IL2RA IL2 SYK BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs PTGS2 ALOX15 ALOX12 ALOX5 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 95%212300 PRC2 methylates histones and DNA PHF1 H2BC9 H2AZ2 H4C9 JARID2 H2BC8 H2BC5 EED H2BC3 H2BC1 EPOP H2AC20 AEBP2 MTF2 RBBP4 EZH2 RBBP7 H2AX DNMT1 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EZHIP PHF19 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 DNMT3B H2BC12 SUZ12 H2BC13 H2BC14 H2AJ DNMT3A H2BC15 H2BC11 H3C15 EZH1 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 95%194315 Signaling by Rho GTPases ARPC1B ARPC1A KLC1 KLC4 KLC3 KLC2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 ACTR3 ACTR2 PPP1R12B PPP1R14A PRC1 ROPN1 KLK3 KLK2 CTTN TAX1BP3 KIF5B KIF5A NCKIPSD KDM4C YWHAE YWHAQ YWHAG YWHAH KIDINS220 C1QBP SPTAN1 HGS BCAP31 TJP2 TRIO RASGRF2 ITSN1 ARHGEF10L AKAP13 PREX1 MCF2L PRKCB RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 FLOT1 ARHGEF19 FLOT2 ARHGEF18 VAV1 DSP VAV2 TIAM2 TIAM1 ARHGEF9 OBSCN DSG1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 UACA ARHGEF5 NGEF ARHGEF6 ARHGEF26 KALRN FGD1 FGD2 GNA13 FGD3 ABR FGD4 ECT2 ARHGEF39 MCF2 NET1 CCP110 AR CFTR BTK STAM CFL1 ACTB MEN1 USP9X CCT6A ABL1 TUBA1B STAM2 VCP CYFIP2 ITSN2 ANKLE2 STMN2 GJA1 EPSTI1 ANKFY1 CEP97 NISCH MTMR1 SHMT2 HMOX2 NUP107 FAM135A VANGL2 ARHGAP8 AAAS OSBPL11 LRRC1 NUP160 RRAS2 CIT NUP85 PKN3 FGD5 CHN2 STX5 FARP2 WWP2 NUP43 WDR11 LETM1 TMEM59 VMA22 RANBP2 GOPC SEC13 FILIP1 PKN2 NUP133 PKN1 PLXND1 FAM13A STK10 SLK POTEE TPM4 RALGAPA1 TPM3 FAM91A1 TEX2 NUP37 ARMCX3 ERCC6L PKP4 ZWILCH RASAL2 BUB1B STIP1 ACTG1 DDRGK1 CDC20 PPP1CC PLXNA1 ANKRD26 PPP2R1B NSFL1C PPP2R1A CPD KNTC1 MRTFA PLXNB1 ARHGAP11A KNL1 ZNF512B SGO1 DYNC1LI1 CAPZB EFHD2 SGO2 DYNC1LI2 NCK2 DAAM1 WDR6 NCK1 ZW10 DST PFN1 MAD1L1 PLEKHG6 NIPSNAP2 PFN2 CDCA8 BLTP3B PARD6B PMF1 SKA1 SH3BP1 SKA2 WHAMM WASF3 DSN1 DVL1 NDUFA5 DVL2 PCDH7 DVL3 SEMA4F SRGAP2 PTPN13 VAPB SCAI ATP6AP1 GOLGA3 RCC2 PDPK1 CKB NDC80 BAIAP2L2 KCTD13 ZWINT FRS2 TMEM87A DIAPH1 GRB7 KIF18A PIK3CA PIK3R3 RPS27 SCFD1 DIAPH3 ITGB1 SPTBN1 PIK3C3 CCDC88A AHCTF1 ANLN PPP2R5E NUF2 FAF2 SPDL1 SOS1 KIF14 SH3RF1 NDEL1 NUDC AKAP12 HINT2 PPP2R5B RAC2 PPP2R5A MUC13 PPP2R5D PIK3R4 RHOG PPP2R5C DYNLL1 PIK3R2 RHOH PIK3R1 RHOF RHOC RANGAP1 RHOJ RHOD RHOU RHOV CKAP5 DYNLL2 RHOQ RHOA SAMM50 RHOB EMC3 KIF2A MTX1 MAPK1 INCENP CAVIN1 BIRC5 MYO9A EVL TRIP10 KIF2C RTKN KIF2B PRAG1 MAPRE1 SYDE2 BASP1 ITGB3BP PAFAH1B1 ALDH3A2 DYNC1I2 ELMO2 SRF DDX4 MIS12 ARHGEF28 MAPK3 CENPA ARHGAP19 ARHGAP18 AURKB NSL1 TOR1AIP1 CENPC ARHGAP12 CDC42 PLD2 PPP2CA RHPN1 PPP2CB RHPN2 FAM83B BUB3 ACBD5 BUB1 DYNC1I1 MACO1 ARHGAP28 CLASP1 ARHGAP25 CLASP2 CENPT ARHGAP23 DYNC1H1 DIAPH2 CENPU UBXN11 NDE1 DLG5 PICALM FMNL3 CENPE SRC DOCK5 CENPF DOCK4 ABCD3 FMNL1 DOCK3 FMNL2 CENPH SOWAHC CENPI MTR TAOK1 TNFAIP1 CENPK RND2 CENPL RND3 CENPM RND1 CENPN CKAP4 B9D2 SENP1 CENPO ZAP70 CENPP GFOD1 CENPQ DLG4 ALS2 SPC24 PEAK1 CALM1 SPC25 NDUFS3 MAD2L1 DOCK2 CENPS DOCK1 CCDC187 MOSPD2 FAM169A PLK1 ADD3 PTK2B HSPE1 SLC4A7 ACTC1 CTNNA1 CSK PPP1CB FRS3 JAG1 PPP1R12A LCK CLIP1 DBT CLTC S100A9 S100A8 FLNA LIMK2 LIMK1 MYL12B MYL6 MYH9 MYH14 MYH11 MYH10 HSP90AB1 TWF1 MSI2 RHOBTB2 ACTN1 TMOD3 DDX39B PHIP CTNNB1 CDH1 YWHAB MYL9 XPO1 LAMTOR1 CYFIP1 NCKAP1 PRKCD PRKCA NCF1 TFRC SFN YWHAZ NCF2 NCF4 SNAP23 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 EMD LBR GIT1 TMPO SWAP70 ARAP2 CYBB ARAP3 CYBA OCRL VRK2 LEMD3 BCR DEPDC1B RAPGEF1 CDC42EP1 DSG2 VAMP3 RAB7A EPHA2 GARRE1 AMIGO2 NOXO1 ARHGAP17 SLC1A5 ARHGAP15 MAPK14 ARHGAP21 MAPK11 LMAN1 PAK1 PGRMC2 RACGAP1 SLITRK3 NHS MYLK ABL2 SLITRK5 NCKAP1L WASF1 PAK2 YKT6 WASF2 PAK4 IL32 GIT2 CAV1 MCAM ERBIN ARHGAP26 BAIAP2 MPP7 VANGL1 ARHGAP32 ABI2 TAOK3 NOXA1 ABI1 NOX3 ESYT1 FERMT2 NOX1 RNF20 SPEN CCT2 CPSF7 ROCK1 ROCK2 GPS1 CUL3 TXNL1 LMNB1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 MYO6 STK38 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 CPNE8 STEAP3 FAM13B WIPF1 WIPF2 WIPF3 ARHGDIG FNBP1L ARHGAP44 PREX2 DOCK11 ARHGAP40 ARHGDIA WDR91 GOLGA8R RALBP1 FNBP1 STARD8 SCRIB LIN7B KCTD3 ARHGAP45 WDR81 SPATA13 ARHGEF25 IQGAP1 PLD1 IQGAP2 IQGAP3 ARHGAP22 ARHGAP20 SRGAP3 HSP90AA1 SRGAP1 STARD13 JUP CDC37 ARHGAP29 CDC25C ARHGAP27 ARHGAP24 ARHGAP33 CDKN1B ARHGAP31 DNMBP ARHGAP30 MAP3K11 CDC42SE2 DOCK6 ARHGAP9 ARHGAP11B DOCK9 DOCK8 DOCK7 WASL ARHGAP4 SH3PXD2A TAGAP PLEKHG3 PLEKHG4 H2AX PLEKHG1 ARAP1 GMIP ARFGAP3 H2AB1 H2AC19 ARFGAP2 H2BC26 ARHGAP10 H2AC14 CDC42EP5 CDC42EP4 H2BC12L CDC42EP3 H2BC21 CDC42EP2 WAS PARD6A H3-3B PLEKHG4B CHN1 H3C8 PRKCZ PAK6 H2AC8 H2AC6 STOM PAK3 H2AC7 PAK5 H2BC17 FARP1 MYO9B H2BC12 CDC42BPB H2BC13 CDC42BPA H2BC14 DEF6 H2AJ KTN1 H2BC15 SHKBP1 DLC1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 ARL13B KDM1A PIN1 NCOA2 PTK2 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes NCF1 ATP6V0D1 NCF2 ATP6V0C NCF4 ATP6V0D2 ATP6V1B1 ATP6V1A RAC2 ATP6V0A2 ATP6V1H HVCN1 ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F NOS1 ATP6V1C2 CYBB ATP6V0A1 CYBA LPO TCIRG1 SLC11A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B MPO ATP6V0E1 NOS2 ATP6V1G2 NOS3 ATP6V1B2 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4615885 SUMOylation of DNA replication proteins NUP85 TPR PCNA NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 RANGAP1 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 INCENP NUP50 BIRC5 NUP35 NUP54 NUP37 TOP2A AURKB PIAS3 SUMO3 SUMO2 UBE2I CDCA8 SUMO1 TOP2B TOP1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 95%114608 Platelet degranulation TMX3 CD109 SELENOP SERPING1 CFD TAGLN2 SCG3 NHLRC2 TEX264 STXBP2 ENDOD1 PDGFB A1BG CLU KNG1 CYB5R1 TGFB1 APOH VTI1B APOA1 HSPA5 APOOL RARRES2 IGF2 RAB27B IGF1 PPBP CYRIB MANF SELP TF SCCPDH CALU MAGED2 HRG FERMT3 LGALS3BP SERPINA3 A2M ORM1 PECAM1 ECM1 SERPINA1 WDR1 PLEK OLA1 CTSW ORM2 SERPINA4 PSAP ALB TMSB4X PHACTR2 TIMP3 QSOX1 TIMP1 SRGN CAP1 ABCC4 AHSG ANXA5 F5 F8 MMRN1 TOR4A CD63 ITIH4 ITIH3 PLG TTN CLEC3B CDC37L1 SPP2 LEFTY2 LY6G6F LHFPL2 PCYOX1L EGF CD9 FLNA FN1 PFN1 PCDH7 ITGB3 ITGA2B BRPF3 SPARC SERPINE1 ACTN1 TGFB2 TGFB3 ACTN2 CALM1 CD36 VEGFB VEGFC THBS1 VEGFD VEGFA ALDOA CFL1 FGB FGA VWF FGG PF4 TLN1 VCL SOD1 PPIA APP TUBA4A F13A1 POTEKP ISLR LAMP2 PROS1 HABP4 FAM3C CHID1 HGF GAS6 APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.2 RHOT1 GTPase cycle TRAK1 TRAK2 RHOT1 RAP1GDS1 MYO19 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-139910.5 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GALNS FMOD HEXB HEXA GNS GLB1L3 PRELP GLB1L2 OMD KERA GLB1L GLB1 ACAN OGN LUM RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 95%5663213 RHO GTPases Activate WASPs and WAVEs BAIAP2 BRK1 ABI2 ABI1 ARPC1B ARPC1A ABL1 BTK MAPK1 ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 WASL ACTR2 ACTG1 MAPK3 ACTB CDC42 NCK1 WAS NCKIPSD WIPF1 WIPF2 CYFIP2 WIPF3 RAC1 WASF3 NCKAP1L WASF1 WASF2 PTK2 CYFIP1 NCKAP1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 95%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 95%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PIP5K1C ARHGAP32 FURIN RPN2 PCSK6 JUP PRKCSH RPN1 GANAB CSNK2A3 PCSK7 CTNNB1 POMT2 SPCS3 SPCS2 SPCS1 OST4 SEC11A POMT1 SEC11C MOGS DDOST TMEM258 DAD1 OSTC CANX STT3A CDH1 CSNK2A1 CSNK2A2 ANK3 CSNK2B TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 95%174417 Telomere C-strand (Lagging Strand) Synthesis ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP BLM CHTF8 WRN PRIM2 PRIM1 POLA1 DSCC1 POLA2 LIG1 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 FEN1 CHTF18 RFC2 RFC1 STN1 RPA1 TEN1 RPA2 RPA3 DNA2 CTC1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME%R-HSA-9028731.2 Activated NTRK2 signals through FRS2 and FRS3 HRAS SOS1 NTF4 NTRK2 BDNF FRS3 FRS2 NRAS PTPN11 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9608287 Defective MUTYH substrate binding CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8963684 Tyrosine catabolism HGD TAT FAH HPD GSTZ1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 95%196836 Vitamin C (ascorbate) metabolism SLC2A1 CYB5R3 SLC2A3 CYB5A SLC23A2 SLC23A1 GSTO2 GSTO1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 95%180689 APOBEC3G mediated resistance to HIV-1 infection BANF1 PSIP1 PPIA HMGA1 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 95%168268 Virus Assembly and Release CANX CALR DEFECTIVE GALK1 CAUSES GALCT2%REACTOME%R-HSA-5609976.5 Defective GALK1 causes GALCT2 GALK1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 IGHV3-23 V1-13 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-8 V1-20 IGHV3-33 IGKV1D-39 IGKV1D-33 V1-9 V5-4 IGKV2D-28 V1-7 IGKV4-1 V5-1 IGHV7-81 V1-5 V1-3 IGKV2D-30 V5-6 IGHV4-59 IGHV1-69 C1QB C1QA C1S IGLV2-11 C1R IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 V4-6 V4-2 IGKV3-15 V4-1 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 C1QC IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 CRP IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%73884 Base Excision Repair MBD4 H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 SMUG1 NEIL3 H2BC3 H3-4 PARP1 NEIL2 H2BC1 POT1 TERF2IP NEIL1 H2AC20 MPG FEN1 POLB H2AX PNKP LIG1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLE POLD2 OGG1 H2BC21 RFC2 RFC1 PARP2 LIG3 RPA1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 XRCC1 H2BC14 POLE4 H2AJ RPA3 H2BC15 H2BC11 POLE2 POLE3 PARG NTHL1 APEX1 ADPRS TDG MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%453279 Mitotic G1 phase and G1 S transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 ABL1 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 MYBL2 DHFR TK1 CDKN2D CDKN2C CDKN1C RB1 DYRK1A CDKN1B CCND3 RRM2 CCND2 E2F1 RBBP4 E2F2 E2F3 SKP2 CABLES1 FBXO5 CDK6 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 TOP2A PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDKN2A CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN CCNB1 PSMA2 UBA52 CDKN2B PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 JAK2 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PPP2R2A PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 95%9665251 Resistance of ERBB2 KD mutants to lapatinib ERBIN HSP90AA1 ERBB2 CDC37 SIGNALING BY FGFR%REACTOME%R-HSA-190236.4 Signaling by FGFR FLRT1 SOS1 PIK3R1 NRAS FGF20 MAPK1 FLRT3 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 PTBP1 HNRNPM TGFBR3 HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L GIPC1 ANOS1 FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 SPRED2 SPRED1 ESRP2 KLB TIAL1 BRAF UBB GALNT3 PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FGFRL1 FLRT2 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 95%3656225 Defective CHST6 causes MCDC1 FMOD PRELP CHST6 OMD KERA ACAN OGN LUM ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 95%112303 Electric Transmission Across Gap Junctions GJA10 PANX1 PANX2 GJD2 GJC1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 95%209563 Axonal growth stimulation ARHGDIA NGFR NGF RHOA REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9818749 Regulation of NFE2L2 gene expression CREBBP MAFK RELA NFE2L2 EP300 NFKB1 MYC NOTCH1 ETHANOL OXIDATION%REACTOME%R-HSA-71384.5 Ethanol oxidation ALDH1B1 ADH7 ACSS1 ADH5 ADH6 ADH1C ALDH1A1 ALDH2 ADH1A ADH4 ACSS2 ADH1B EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 95%168274 Export of Viral Ribonucleoproteins from Nucleus NUP85 TPR NUP62 NUP88 NUP43 RAE1 RAN NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 HSPA1A XPO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9701192.4 Defective homologous recombination repair (HRR) due to BRCA1 loss of function BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGEF1 ARHGAP32 RHOC ARHGEF5 PIK3R1 RHOA ROCK1 CAVIN1 ROCK2 ABR RTKN ARHGEF28 ARHGAP18 MCF2 ACBD5 MACO1 FMNL3 ABCD3 FMNL2 ARHGDIA CIT ARHGEF25 CCDC187 PKN3 IQGAP1 TFRC IQGAP3 STX5 ARHGAP1 ARHGAP39 ARHGAP5 STARD13 JUP ARHGAP35 PKN2 PKN1 OPHN1 STK10 SLK C1QBP LBR TMPO BCR DEPDC1B TJP2 VAMP3 DAAM1 ARHGEF10L AKAP13 ARHGAP21 PREX1 LMAN1 STOM MCF2L ARHGEF40 RACGAP1 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 VAPB DLC1 ARHGEF17 DIAPH1 FLOT1 FLOT2 DIAPH3 VAV2 CAV1 MCAM ANLN SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 95%9753512 Signaling by RAS GTPase mutants HRAS NRAS KRAS SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 95%9834899 Specification of the neural plate border MSX1 DLX5 TFAP2A FGF4 TFAP2B BMP4 MYB TCF7L1 TFAP2C PAX7 POU5F1 SOX2 PAX3 ZIC1 WNT3A CTNNB1 GBX2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 95%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation PCSK9 C3 SCG3 CP SPP1 KNG1 APOA2 APOA1 APOA5 TF CALU SERPINA1 MBTPS1 ALB P4HB IL6 QSOX1 TIMP1 APOB AHSG F5 VCAN ANO8 CSF1 C4A LGALS1 SPP2 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 LAMB2 PDIA6 MXRA8 SPARCL1 FN1 LAMB1 SCG2 LAMC1 TGOLN2 STC2 PENK IGFBP7 AMELX WFS1 AMBN TMEM132A FUCA2 HRC MELTF BPIFB2 SERPINA10 MIA3 MSLN PRSS23 CHRDL1 BMP15 MEPE DNAJC3 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 SERPIND1 KTN1 GOLM1 NUCB1 NOTUM HSP90B1 LTBP1 TNC BMP4 DMP1 PRKCSH FBN1 ADAM10 FGF23 APOE MATN3 SDC2 MGAT4A GPC3 CKAP4 PNPLA2 FGA FGG CDH2 MEN1 IGFBP1 APP IGFBP3 PROC GAS6 APLP2 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism SLC22A5 PPARD CYP4B1 FAAH NUDT7 ACSM3 PCCA CRAT ECI1 PCCB THRSP ACSM6 PTGDS ACAD11 ACAD10 PLA2G4A GGT5 PTGES GGT1 DECR1 ALOX15B LTC4S GPX2 ACADL HADHB HADHA ACADVL ACADM ACADS CBR1 CYP2C9 NDUFAB1 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 SLC27A1 HACD1 TECR HSD17B3 PTGES2 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 ALOX12 MORC2 CBR4 ACOT9 ELOVL1 OLAH CYP8B1 ELOVL4 ACOT7 ACSL1 MECR ELOVL5 ELOVL2 ACAA2 SCD5 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 HADH ACSL3 ACOT1 TECRL ACSF3 ACLY RXRA SCD FASN ACOT11 PPT1 ACOT12 ACSBG1 ACOT13 PPT2 SLC27A3 ACSBG2 SLC27A2 DPEP2 DPEP1 ALOX15 PECR THEM4 LTA4H PTGES3 CYP4F3 CYP4F8 SCP2 MCAT CYP2J2 NUDT19 ACBD7 PRXL2B ACBD6 ACOT7L ACAA1 ACBD4 PRKAA2 PHYH ACOT8 ACSF2 PRKAG2 MCEE ACBD5 PTGR1 ACOT2 CYP4A22 PTGR2 DBI ACOT4 PCTP ACOXL PRKAB2 ECHS1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 HACL1 PON3 HPGD DECR2 PON2 HAO2 PON1 EPHX2 FADS2 HPGDS FADS1 AMACR ALOX5AP MAPKAPK2 CROT CYP4F22 CPT2 MID1IP1 THEM5 SLC25A20 CPT1B ABCD1 CPT1A CYP4F11 SLC25A17 ACOX2 TBXAS1 EHHADH ACOX3 GPX1 GPX4 FAAH2 AKR1C3 HSD17B4 MMAA MMUT AWAT1 ALOXE3 XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics CYP3A7 CYP2E1 CYP2F1 ARNT AHRR CYP2W1 CYP2D6 ARNT2 CYP3A5 CYP2C18 CYP2C9 CYP2A13 CYP2C8 CYP2B6 CYP2J2 CYP2S1 CYP3A4 CYP1A2 CYP3A43 CYP2A7 CYP1A1 CYP2A6 AHR CYP2C19 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 95%9694614 Attachment and Entry AGRN ACE2 FURIN GPC1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 HSPG2 VCP TMPRSS2 NRP1 SDC1 CTSL SDC4 SDC2 SDC3 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.5 FRS-mediated FGFR1 signaling SOS1 FGF1 FGF10 FRS3 FGF2 FGF3 FGF4 FGF6 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FRS2 PTPN11 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus SQSTM1 UBC RPS27A NGF TRAF6 UBA52 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 MAPK8 ITGB3BP NGFR UBB FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190242 FGFR1 ligand binding and activation FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF9 TGFBR3 FGF20 GIPC1 ANOS1 FGF23 FGF22 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 NPAS4 TNRC6A TNRC6B REST SRF NR3C1 KCNIP3 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 95%9006936 Signaling by TGFB family members PMEPA1 FURIN BAMBI CER1 STRAP TGFB1 UBE2M TGFBR1 TGFBR2 SKIL SKI CDK8 SMAD2 TIMP2 SMAD1 SMAD4 SMAD3 YBX1 SMURF2 SMAD7 BMP2 TIMP1 CCNT2 TCF3 ARRB1 ARRB2 TGIF1 TGIF2 CBL USP15 TFDP1 TFDP2 PPP1CC CHRDL1 FGF2 EP300 JUNB PARD6A CGN F11R RNF111 PRKCZ PARD3 FSTL1 FSTL3 BMP10 LTBP4 RARA ITGB3 ARHGEF18 LTBP3 ITGB1 LTBP1 ITGAV NEDD4L RXRA ACVRL1 BMPR2 AMHR2 GDF2 SMAD9 ITGB8 SMAD5 ITGB5 SERPINE1 GREM2 ZFYVE16 PARP1 BMPR1B BMPR1A HDAC1 APH1A RHOA ITGB6 PSENEN MAPK1 NCSTN APH1B PSEN2 PSEN1 ITGA8 INHBB INHBA PPP1R15A INHA MAPK3 TGFB2 ATP1B4 TGFB3 NCOR2 TNRC6C MTMR4 MOV10 MYCN NCOR1 AGO3 AGO4 SNW1 MYC SMURF1 SMAD6 AGO1 TGFBR3 AGO2 TNRC6A TNRC6B E2F4 FKBP1A PPM1A E2F5 UBE2D3 TCF12 XPO1 RBL1 STUB1 UBE2D1 TRIM33 CCNK CCNC UBA52 AMH CDKN2B GIPC1 NOG COL1A2 FST PPP1CA FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C CCNT1 PPP1CB UBB UBC SP1 UCHL5 CDK9 RPS27A MYOG NEDD8 MEN1 MYOD1 WWTR1 MYF6 TCF4 MYF5 HELLS KLF16 USP9X MMP14 MMP16 PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.5 Pregnenolone biosynthesis STARD4 TSPO STAR STARD6 CYP11A1 FDX1 FDX2 FDXR STARD3 STARD3NL AKR1B1 TSPOAP1 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 MDC1 WEE1 YWHAB YWHAE YWHAQ YWHAG RNF168 YWHAH NSD2 YWHAZ SFN PIAS4 BRCC3 CCNB1 CDC25C CDK1 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN TOPBP1 ATRIP BARD1 RFC5 RMI2 H2BC26 RFC3 RFC4 H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 CHEK2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 TP53 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 95%176408 Regulation of APC C activators between G1 S and early anaphase CDK2 BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 PLK1 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 ANAPC5 PSMD14 FZR1 BTRC ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 FBXO5 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate PCNA POLD3 POLD4 POLD1 POLD2 FEN1 RPA1 RPA2 RPA3 DNA2 PRIM2 PRIM1 POLA1 POLA2 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702596 lestaurtinib-resistant FLT3 mutants FLT3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBC RPS27A JAG2 JAG1 ADAM17 NEURL1B UBA52 MIB2 DLL4 DLL1 MIB1 NEURL1 ADAM10 NOTCH1 UBB GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 95%888568 GABA synthesis GAD1 GAD2 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) RAD52 RAD50 XRCC1 MRE11 BRCA2 FEN1 PARP1 PARP2 LIG3 RBBP8 NBN POLQ VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation PRKCA KDR ITPR1 ITPR2 ITPR3 RASA1 NRAS PLCG1 PRKCZ PRKCB HRAS AHCYL1 PDPK1 SPHK1 CALM1 PRKCD DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.4 Diseases associated with surfactant metabolism SFTPA2 ABCA3 SFTPD SLC34A2 SFTPB SFTPC SFTA3 SFTPA1 CSF2RB CSF2RA DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME%R-HSA-9845622.1 Defective VWF binding to collagen type I VWF TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35A1 SLC35B2 SLC35B4 SLC35D1 SLC35C1 SLC35D2 SLC35A2 SLC35A3 SLC35B3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes CREB3 CREB3L4 CREB3L1 CREB3L2 MBTPS1 CREB3L3 CREBRF DCSTAMP MBTPS2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 95%3296469 Defects in cobalamin (B12) metabolism TCN2 CD320 CUBN CBLIF MMAB AMN MMACHC MMADHC ABCD4 MTR MTRR MMAA MMUT LMBRD1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.4 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma HBEGF TGFA AREG EGF EGFR PLCG1 EREG BTC EPGN LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations UGT2B7 CYP51A1 GSTA3 GSTA1 COMT CES3 HEMK2 GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC CHAC2 GGT3P GGT1 GCLM ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 CES1 FMO3 MAT1A CYP2C9 NNMT CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 AHCY SLC35D1 SLC35D2 CYP2D6 CMBL ALDH3A1 FDXR POR SULT2A1 CES2 MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 CYP2B6 EPHX1 CYP2S1 FDX1 CYP4V2 FDX2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP2E1 CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 GSTM4 PTGES3 CYP4F3 CYP4F8 GSTK1 CHAC1 PODXL2 CYP27B1 ABHD14B SULT1A1 CYP26A1 SULT1C2 CYP26B1 SULT1B1 CYP24A1 SULT1E1 CYP26C1 CYP21A2 CYP2R1 BPNT2 AHRR BPNT1 SULT6B1 SULT1A4 SULT4A1 SULT1A2 TRMT112 SULT1C4 CYP4F12 PTGS1 NR1H4 AHR HPGDS CYP4F22 CYP19A1 GSTO1 CYP4F11 AIP NAT1 NAT2 TBXAS1 GSTA2 PAOX SULT1A3 GLYATL3 GLYATL2 ALDH2 GLYATL1 ACSM2A CYP3A4 ACSM5 GLYAT ACSM4 UGT1A9 CYB5B CYP4B1 CYB5R3 CYP27A1 CYP39A1 GSTP1 AOC1 MTRR CYP7B1 CYP7A1 MAT2B CYP8B1 TPST2 TPST1 CYP46A1 RXRA DPEP2 DPEP1 ARNT2 TPMT AS3MT AKR1A1 GSTT2 GSTT1 CYP11A1 ESD GSTT2B UGT1A3 GSTM3 CYP2J2 GSTM2 GSTM1 GSTM5 NCOA1 GSTO2 MAT2A GSTA5 GSTA4 CYP11B2 ARNT CYP4A22 ACSM1 ACSM2B PTGIS MTR NCOA2 POMC GSTZ1 CYP11B1 ADH1C ADH1A UGT1A10 UXS1 ADH4 UGT2B28 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 ALDH1A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 UGT2B15 UGT2B17 UGDH UGT2B4 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A7A S100A9 LCN2 S100A8 LTF S100A7 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%9037629 Lewis blood group biosynthesis ST3GAL4 FUT2 B4GALNT2 B3GALT2 B3GALT1 ST3GAL6 FUT4 FUT6 FUT5 ST3GAL3 FUT7 FUT9 B3GALT5 FUT3 B3GALT4 ST6GALNAC6 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 95%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 95%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A METABOLISM%REACTOME DATABASE ID RELEASE 95%1430728 Metabolism SLC26A2 SLC22A5 ABCB4 SLCO1B1 SLCO1B3 ABCD4 SLC2A1 SLC2A2 ABCC2 LMBRD1 ABCB11 OXA1L KGD4 NDUFAB1 CYP2C9 CYP2C8 CYP2U1 CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 B4GAT1 TIAM2 CHST3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ACAT1 PTGES3 B3GAT3 CYP27B1 CYP26A1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 UBE2I PIP5K1C ERCC2 GBA1 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GLYATL3 TP53 GLYATL2 GLYATL1 ACSM2A GNG10 ACSM5 GLYAT ACSM4 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 XDH GNA14 GNG3 GNA15 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A4 NUP37 PPP1CC PPP2R1B PPP2R1A PPA2 PPA1 RPS27 PPP2R5D DCXR AKR1A1 SORD CRYL1 XYLB IPPK IPMK ISYNA1 IP6K1 INPP1 IP6K2 NUDT3 NUDT4 VAC14 PI4K2B INPP5B MTMR10 NUDT11 PPP2CA NUDT10 PPP2CB MTMR2 MTMR12 INPP5A PIK3C2A IMPA1 PPIP5K1 MTMR4 MTM1 PLCZ1 IMPA2 INPP4A PPIP5K2 FIG4 PLCE1 INPP4B IP6K3 PIKFYVE MIOX INPP5F PI4K2A ITPK1 ITPKB ITPKC MINPP1 ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 ATIC OAT GLS2 GOT2 PYCR1 PYCR2 PYCR3 GLS CPT2 GLUD1 MID1IP1 GLUD2 KYAT1 SLC25A20 CPT1B RIMKLA GLUL RIMKLB CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT ADH1C ADH1A ADH4 RDH11 SIRT5 AKR1C3 MARCKS PRPS2 ALDH1A1 PRPS1 RPEL1 IDI1 MVK RPE SHPK TM7SF2 PGLS PMVK PRPS1L1 SC5D FDFT1 RBKS FDPS HMGCS1 GGPS1 CYP51A1 LSS SREBF2 SQLE MTF1 DHCR7 NQO1 GSTA3 GSTA1 RAP1A PRKACG PRKACA PRKACB RAPGEF3 COMT BLVRB RAPGEF4 BLVRA CA12 CA1 CA3 CA5B CA2 CA5A CA4 CA7 CA6 CA9 CA14 CA13 PLCG2 GCHFR CHRM3 GCH1 SPR PTS PCK2 SLC37A1 G6PC2 G6PC3 RPS4Y2 FBP1 RPS27L FBP2 RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 RPS24 B3GNT7 RPS23 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 GCKR GCK HSP90AB1 LYPLA1 CYGB DDAH1 PRKAA2 PRKAG2 PODXL2 ABHD14B SULT1A1 STK11 SULT1C2 SULT1B1 SULT1E1 BPNT2 BPNT1 SULT6B1 PRKAB2 SULT1A4 SULT4A1 SULT1A2 SULT1C4 MAN2B2 MAN2C1 LBR OCRL NAT1 NAT2 GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM ITPA CAV1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 HAS2 SPAM1 FOLH1 FOLH1B ASPG NAALAD2 NAT8L SEC23A ASPA B3GALT6 B4GALT7 PNMT DDC TH DBH SEC24B SEC24A IQGAP1 PLD1 SEC24D SEC24C WASL TCN2 CD320 FUT3 TPST2 TPST1 NOSIP B3GNT3 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 AS3MT RPL32 GSTT2 HSPG2 RPL31 GSTT1 RPLP1 RPL34 ESD RPL10L GSTT2B GSTM3 RPL8 GSTM2 RPL10A GSTM1 RPL6 GSTM5 RPL7 GSTO2 RPL7A RPL18A MAT2A ACAN RPL36AL GSTA5 GSTA4 LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD RPL23 RPL22 RPL13A RPL9P9 SUMO2 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 GPI ADPGK RPL26L1 ENO1 ENO2 ENO3 MRI1 ENOPH1 HK2 BHMT2 ENO4 HK3 BHMT ADI1 TPI1 PGAM1 PGAM2 BPGM PGM2L1 HKDC1 ALDOC ALDOB ALDOA GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK1 PGK2 PFKL ECSIT GNPDA1 GNPDA2 PFKM PFKP CREBBP SP1 GLYCTK KHK GPT MED19 MED18 MED11 KCNJ11 ABCC8 ADCY9 ADCY4 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 MED21 ADCY6 ADCY5 CDK19 MED13L PRKG2 HEMK2 PLA2G4A GGT5 GGT7 GGT6 GSS OPLAH CNDP2 GGCT GCLC ITPR1 CHAC2 GGT3P ITPR2 GGT1 ITPR3 GCLM LRP8 APOB NOS3 CES1 DHFR TK1 GNAS HILPDA CIDEA FITM1 HSD17B13 FITM2 CIDEC RAB5A KPNB1 TYMS SLC3A2 NSDHL LIPI CYP2D6 LIPH FDXR SULT2A1 STARD3 SLC36A4 ACOT9 STARD4 STARD5 ACOT7 MECR STARD6 STARD7 RUFY1 CH25H PRKD3 SLC6A12 FDX1 SLC7A5 FDX2 PLBD1 ACOT1 FAR1 PRKD2 PRKD1 CYP2E1 FAR2 MTMR3 MTMR8 PLA2G3 MTMR9 PLA2G5 PLA2G6 MTMR6 MTMR7 HSD11B1 HSD11B2 PTPMT1 PIP5K1A PIP5K1B LTA4H GSTM4 CHKB CHKA CYP4F3 STARD10 CYP4F8 MCAT FA2H PRXL2B ACOT7L LGMN ARF3 ACHE MTMR14 LPCAT1 SERPINA6 OSBPL10 MCEE TSPO SPHK2 PTGR1 PTGR2 CYP21A2 AHRR SLC46A1 SAMD8 ECHS1 SGMS1 SGMS2 PTGS2 PTGS1 GPAT4 ALOX5 GPAT3 CEPT1 GC BCHE AGK NR1H4 G0S2 AGT LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 AHR LCLAT1 FADS2 HPGDS OSBP FADS1 PIAS4 VDAC1 PCYT2 PGP PLA2R1 SLC27A5 CSNK1G2 ABHD4 ABHD3 INSIG2 INSIG1 NRF1 CYP4F22 CYP19A1 ACAT2 THEM5 KDSR OSBPL9 OSBPL8 OSBPL7 RAB4A OSBPL6 OSBPL5 SRD5A2 SRD5A1 OSBPL3 OSBPL2 DHCR24 SYNJ2 CYP4F11 SYNJ1 SLCO1A2 TBXAS1 OSBPL1A ALAS1 FHL2 PIK3CD PIK3C2G PIK3C2B ACP6 CERS3 CERS4 PLA2G12A CERS5 GPX1 ALDH1L1 CERS6 DHFR2 GPX4 FAAH2 MTHFR TNFRSF21 MTHFS ALDH1L2 CERS1 MTHFD1 CERS2 MTHFD1L PPM1L MTHFD2 HSD17B14 TPTE MTHFD2L LRP2 SLC25A32 CYP3A4 FOLR2 HSD17B11 SLC19A1 AWAT1 AWAT2 UGT1A9 ALOXE3 TSPOAP1 CYB5B MBOAT7 TPH2 MBOAT1 ASMT DDHD2 AANAT MBOAT2 CYP4B1 DDHD1 RAB14 FAAH LPGAT1 ACSM3 PITPNB GBE1 CPNE7 PYGM ECI1 GYS2 PHKG1 CPNE6 PHKG2 GDE1 GYG2 ACSM6 CPNE1 EPM2A CPNE3 AKR1E2 PHKA1 PTGDS MFSD2B PHKB PHKA2 ACAD11 ACAD10 PPP1R3C MFSD2A NHLRC1 SACM1L SLC51A SLC51B PISD GALT CYP27A1 CYP39A1 PLPP6 PLPP3 PLPP2 PLPP1 PTGES PLA1A LHB PGS1 PTDSS2 PTDSS1 SGPL1 INPP5J INPP5K SCAP DECR1 TMEM86B SLC10A1 SLC10A2 ALOX15B ACER2 ACER1 STAR AKR1B15 PTEN ACER3 PEMT RGL1 CDS2 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 AKR1B1 GLIPR1 ARV1 SPTLC1 SPTLC2 ACADL SPTLC3 ANKRD1 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 ACADM ACADS PANK4 CBR1 PCYT1B PANK2 PCYT1A PANK3 PANK1 STARD3NL DCAKD PLAAT1 PLAAT3 COASY PLAAT2 PPCDC CYP7B1 SLC25A16 NUDT8 PLAAT5 VNN2 PLAAT4 PPCS AKR1D1 ENPP2 GDPD1 ENPP3 ALOX12B GDPD3 SLC25A42 GDPD5 AASDHPPT HSD17B7 CYP7A1 MAT2B ORMDL2 HSD17B1 ORMDL3 HSD17B2 SPTSSB SPTSSA PNPLA7 PLEKHA1 PNPLA8 PTGES2 PLEKHA2 AKR1C1 PLEKHA5 AKR1C2 ORMDL1 PLEKHA6 PLEKHA3 AKR1C4 PLEKHA4 GRHL1 CKMT2 CYP8B1 GAMT GATM ETNPPL PLEKHA8 SLC6A7 PNPLA3 SLC6A8 PNPLA6 CKM CKMT1B ACAA2 INPPL1 SLC6A11 MSMO1 CKB CYP46A1 PLB1 ENPP6 SBF1 HADH SBF2 TPTE2 MIGA2 MIGA1 SPNS2 ACOT11 ACOT12 ACOT13 PLA2G15 PHOSPHO1 PLA2G10 GPD1 DPEP2 DPEP1 ABCG2 IDI2 ALOX15 CHAT PLD4 PLD6 PLD3 ALDH3B2 EBP CYP11A1 DHRS7B ALDH3B1 CYP2J2 ACBD7 ACBD6 ARG2 ACBD4 DGAT2L6 SLC25A2 CRLS1 ACSF2 CYP11B2 PI4KA DEGS1 ALPI DEGS2 PI4KB TNFAIP8 CYP4A22 DBI PCTP ACOXL ABCC3 PLA2G4F ABCC1 PTGIS PLA2G4D PLA2G4E PLA2G4B PLA2G4C GPCPD1 THRAP3 AGPAT5 PON3 HPGD PLA2G1B PON2 PON1 AGPAT1 SELENOI AGPAT3 AGPAT4 FAM120B PLA2G2F HSD3B7 PLA2G2D PLA2G2E HSD3B2 HSD3B1 SGPP2 SGPP1 ALOX5AP CHPT1 GPD1L PPP1CA NME1 PPP1CB MLXIPL FECH ACADSB ADIPOR1 ADIPOR2 NADK2 ACAD8 TYR UCKL1 DCT UCK2 UCK1 PUDP TK2 TYRP1 SLC5A8 SLC26A11 SLC26A1 ACO1 PLCB4 GCGR GCG SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLC5A6 COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ADSL PPAT GMPS ADSS1 ADSS2 GART PAICS PFAS ADRA2C ADRA2A MT-CO1 B4GALT1 TKT SCO2 KCNG2 MT-CO2 MT-CO3 PPARGC1A PPARGC1B KCNC2 MED16 MED15 MED17 MED12 KCNB1 MED14 MED13 MED10 KCNS3 MED27 MED26 SIRT3 ALDH2 MED23 MED25 MED24 MED20 PPARG PPARA PPARD MT-ND6 ISCA2 MT-ND4 ISCA1 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 TMEM126A SUCLG2 SUCLG1 UQCRC2 TMEM126B LDHC LDHB DMAC2L TRAP1 SURF1 ADHFE1 PM20D1 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 OGDH NDUFAF2 SFXN4 NDUFAF3 NDUFAF1 LDHAL6A LDHAL6B HCCS TMEM186 MT-ATP6 NNT RAB5IF ACAD9 COQ10B COQ10A TMEM177 SDHAF2 SDHAF3 SDHAF1 SDHAF4 RORA L2HGDH FH DMAC1 DMAC2 DLST UQCR11 UQCR10 PET117 UCP3 UCP2 ATP5PF ATP5PD TIMMDC1 PET100 MDH1 ATP5PB MDH2 NUBPL ATP5F1C ATP5F1D MT-ATP8 ATP5F1E LYRM2 LYRM4 LYRM7 ATP5PO NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 CSKMT MPC1 MPC2 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 GLO1 COX18 ATP5MC2 ATP5MC3 HIGD1A UQCRH MPC1L ODC1 ATP5MK COX11 AMD1 ATP5MJ OAZ1 COX14 SAT1 OAZ2 NDUFV3 SRM NDUFV2 ATP5MG OAZ3 MED30 NDUFV1 AZIN2 ATP5MF AZIN1 MED31 AGMAT ATP5ME SMS COA3 COA1 GOT1 UQCC3 UQCC2 UQCC1 IDH2 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 IDH3B UQCRFS1 ME3 ME2 IDH3A COA5 NDUFC2 NDUFC1 G6PC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 SLC25A14 NDUFB9 DMGDH NDUFB7 NDUFB6 CHDH SARDH COX4I1 NDUFB5 COX4I2 NDUFB4 ALDH7A1 SYT5 NDUFB3 NDUFB2 MLX ETFDH ALDH4A1 NDUFB1 PRODH FOXRED1 PRODH2 SLC25A27 D2HGDH SLC25A22 NDUFA9 NDUFA8 NDUFA7 ARNT NDUFA6 FAHD1 NDUFA3 RRM2B NDUFA2 NDUFA1 TTC19 UQCRHL SUCLA2 CCNC COX7B COX7C CTSL CAD COX8A DHODH SREBF1 UMPS COX8C COX5B COX5A COX6C GPAM COX6A1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C SAMHD1 VDR ACY3 ACY1 MGST3 MGST1 MGST2 AKR7L CYP3A5 AKR7A2 AKR7A3 CYP2A13 PPM1K AUH QDPR IVD IL4I1 HIBCH PCBD1 ASRGL1 GALM RRM2 HGD TAT FAH HPD CARM1 LALBA NOSTRIN PNPO AOX1 XYLT2 XYLT1 B4GALNT2 NAMPT B3GALT2 PIP4K2A B3GALT1 PIP4K2B PIP4K2C FAM20B FUT4 FUT6 FUT5 FUT7 MED1 FUT9 B3GALT5 GALK1 PXYLP1 MED8 B3GAT2 B3GAT1 GALE MED4 MED6 MED7 HAL CARNMT1 UROC1 AMDHD1 HDC CARNS1 FTCD CGA NR1D1 PIP4P1 GCSH SNAP25 GUK1 PAH GCDH HYKK AADAT SLC25A21 CRYM AASS CDA DHTKD1 CYB5A SLC23A2 SLC23A1 CIAO3 CIAO1 AFMID RIDA UROD NUDT13 NUDT12 NDOR1 NADK GNS UROS ALAS2 BCAT1 CYB5R3 DCTPP1 BCAT2 SLC45A2 ALDH6A1 KYAT3 ESRRA HIBADH THTPA NMRK2 TCN1 NMRK1 KMO PYGB COX10 NAXE PYGL PPOX CDK8 RRM1 NAXD HMBS ACMSD LHPP MMS19 MOCS2 MOCS3 RNLS TPK1 MOCOS CIAO2B SLC22A13 GSTP1 DTYMK HAAO GRHPR AOC1 TDO2 AGL IDO2 IDO1 QPRT SLC25A44 SLC25A51 SLC25A19 SLC25A28 SLC25A37 NUBP1 NUBP2 ENTPD2 GPX2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 GYG1 CD38 CPOX GPHN GLRX5 GLDC HOGA1 SLC19A3 SLC19A2 OCA2 SMARCD3 NMNAT3 NMNAT2 NMNAT1 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMT GLRX NADSYN1 NME3 NME4 ALAD DCTD TXNRD1 CMPK1 PGM2 KYNU CTPS2 CTPS1 PGM1 TTR COX7A2L TXN DERA BST1 VNN1 ARNT2 NFYA NFYB NFYC MANBA GAA NME2 BMAL1 CD44 COXFA4 COX7A2 COX7A1 SLC2A3 MAN2B1 POMC NAPRT PDXK GALNS UGT1A10 UXS1 UGT2B28 SLC9A1 ABHD10 UGP2 UGT1A5 UGT1A4 UGT3A2 UGT2A3 UGT2A2 UGT3A1 UGT2A1 UGT1A8 UGT1A7 UGT1A6 UGT2B10 UGT2B11 UGT1A1 BCKDK UGT2B15 BCKDHA UGT2B17 BCKDHB UGDH DBT UGT2B4 DLD UGT2B7 LDLRAP1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL LDLR GPIHBP1 MBTPS1 APOC3 ALB MBTPS2 FLAD1 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 SDSL SERINC2 PSPH SERINC5 SERINC4 UCP1 HSD17B10 MAPDA GMPR2 ADK AMPD1 GMPR AMPD2 AMPD3 DCK APRT DGUOK PNP HPRT1 ADA ALOX12 PRKAR1B PRKAR2B PRKAR1A PRKAR2A CACNA2D2 PLCB3 CACNB2 PLCB1 PLCB2 CACNA1D DNM2 TPH1 EPRS1 TRMT112 CYP4F12 RAN ABCC5 ABCB7 NT5E ENTPD1 ENTPD5 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M UPP1 UPB1 TYMP RBP4 RBP1 LRAT ABO MMAB MTRR RTEL1 CBLIF MMACHC MMADHC INPP5E MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK3 GK2 LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 FABP1 FABP2 FABP3 FABP4 FABP5 GPD2 FABP7 PNPLA4 PLIN3 PNPLA5 LPIN1 LPIN2 MGLL LPIN3 PDK4 PEX11A CD36 NCOA2 NCOA6 NCOA3 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 PLIN2 BCO1 VKORC1 AKR1B10 CLPS PNPLA2 RBP2 LRP10 LRP12 PNLIP ADIPOQ DSEL DSE UST CHST15 ZDHHC21 ACSS3 AGPAT2 THRSP GAL3ST1 CERK GBA3 GBA2 SMPD3 SMPD2 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 ARSL ARSJ ARSK PSAP ARSH TKFC ARSI ARSF B4GALNT1 ARSG ARSD B3GALNT1 B3GALT4 M6PR GALC GLA PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 FMO3 NMT1 HNMT SEPHS2 RARS1 SECISBP2 MAT1A LARS1 NNMT EEFSEC AIMP1 AIMP2 SEPSECS QARS1 PSTK MARS1 INMT DARS1 SARS1 EEF1E1 AHCY KARS1 CBS IARS1 GNMT CTH SCLY CMBL ALDH3A1 POR CES2 BMX MAOB MTARC2 MAOA MTARC1 ADH7 CYP2C18 ADH5 ADH6 APIP CYP2B6 EPHX1 CYP2S1 CYP4V2 CYP3A43 CYP2A7 CYP2A6 ACSS2 ADH1B BPHL CYP3A7 ALDH1B1 CYP2F1 ACSS1 CBR3 AOC3 NQO2 AOC2 FMO1 FMO2 CYP2W1 AADAC PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 SDC2 SDC3 HS6ST1 HS6ST2 SGSH HS2ST1 HS6ST3 NDST2 NDST1 EXTL2 NAGLU NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 RPIA GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO IYD DUOXA1 DUOXA2 DUOX2 TSHB INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RPLP0 HSPA9 GSTO1 AIP TALDO1 MTAP GSTA2 AHCYL1 SULT1A3 MMAA MMUT PGD MCCC2 BTD PC PCCA HLCS MCCC1 PCCB ACACB FFAR1 TMLHE SHMT1 BBOX1 ALDH9A1 MTMR1 SHMT2 HMOX2 LETM1 GYS1 RHCE RHD PIK3CB NDUFA5 PTPN13 VAPB PIK3CA PIK3R3 PIK3C3 TRIB3 PIK3R4 PIK3R2 PIK3R1 STXBP1 INS THEM4 CACNB3 PLD2 CACNA1A ACBD5 CACNA1E ACSM1 ACSM2B MTR CALM1 NDUFS3 WDR26 PDHB RMND5B LDHA MPST TSTD1 MAEA SQOR PDPR GADL1 RMND5A SUOX ME1 NEK1 ADO CSAD PDK3 TXN2 DLAT TST PDK2 PDK1 ETHE1 PDHX SLC25A10 PDHA2 CDO1 PDHA1 GLP1R SIRT4 BRIP1 RANBP9 ARMC8 PDP1 GSTZ1 MKLN1 PDP2 GID4 GID8 CYP11B1 HMMR SEM1 SLC25A15 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC PRSS3 PDZD11 PLA2G2A HACD1 TECR HSD17B3 HSD17B12 HACD3 HACD2 HSD17B8 ACACA HACD4 HTD2 MORC2 CBR4 ELOVL1 CHPF OLAH CHSY1 ELOVL4 CHST11 ACSL1 ELOVL5 CHST12 CHSY3 ELOVL2 CHST13 SCD5 CSGALNACT1 ELOVL3 CHST7 ACSL6 CHPF2 ACSL5 CSGALNACT2 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 ACLY SCD FASN PPT1 ACSBG1 PPT2 SLC27A3 ACSBG2 SLC27A2 PECR SIN3A SCP2 NUDT19 ACAA1 GSTK1 ASNS PHYH ACOT8 CHAC1 PIPOX BCS1L GNPAT ACOT2 STX1A ACOT4 COX19 COX17 ATP5MC1 PSMD8 HMOX1 PSMD6 HACL1 PSMD7 HAO1 CYC1 DECR2 PSMD2 HAO2 PSMD3 AKT1 PSMD1 NUP214 EPHX2 IDH1 PRKCA CS PSMA5 PSMA6 COQ2 PSMA3 AMACR PSMA4 DAO PSMA1 PXMP2 PSMA2 ACO2 MAPKAPK2 CROT UBA52 HSCB PSMD12 PSMD11 CACNA1C PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 TIMM21 BAAT UBB PSMB2 SLC25A17 ACOX2 PSMB3 UBC PSMB1 EHHADH AGPS PRSS1 RPS27A ACOX3 SLC25A12 AGXT FXN VAMP2 SLC25A13 PHYKPL ADRM1 CTRB2 PAOX CTRB1 NDUFB8 PSMC5 TAFAZZIN PSMC6 PSMC3 PSMC4 HSD17B4 PSMC1 PSMC2 DDO HMGCL ATP5F1A ATP5F1B IDH3G CYCS SRD5A3 NUDT7 VAPA CRAT IDUA NCAN HEXB HEXA LTC4S BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB HADHB HADHA ACADVL HSP90AA1 CYP17A1 PLCG1 NMT2 POLD1 EP300 RXRA HDAC3 GPS2 RXRB UGT1A3 APOE TBL1X PCK1 NCOA1 ABCA1 NR1H2 NR1H3 NCOR2 NCOR1 TBL1XR1 FABP6 APOC2 PLIN1 HK1 AKAP5 GNAI1 GNAI2 MVD ST6GALNAC5 ST6GALNAC6 CPT1A NEU2 CLOCK NEU3 NPAS2 HELZ2 NEU1 CHD9 ST3GAL4 SLC17A5 ST8SIA5 ST3GAL5 ST3GAL6 ST3GAL1 ST3GAL2 ST3GAL3 TGS1 CTSA APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 95%351906 Apoptotic cleavage of cell adhesion proteins OCLN DSG1 TJP2 DSG2 DSG3 CTNNB1 TJP1 PKP1 CDH1 DSP CASP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 95%167826 The fatty acid cycling model SLC25A14 UCP1 UCP3 SLC25A27 UCP2 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 95%9758920 Formation of lateral plate mesoderm FOXF1 SHH IHH BMP4 GATA4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 95%432720 Lysosome Vesicle Biogenesis CLTC CLTB CLTA DNASE2 CLVS2 CLVS1 ARF1 CTSZ BLOC1S1 GNS TXNDC5 HGS DNM2 AP4S1 AP4M1 AP1G2 DNAJC6 AP1G1 AP1S2 AP1S1 AP1S3 VAMP7 SH3GL2 AP1M2 HSPA8 AP1M1 VAMP2 AP1B1 VAMP8 APP CHMP2A AP4E1 M6PR ARRB1 AP4B1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane SGTA STX5 STX1A VAPA VAMP2 BAG6 SERP1 SEC61G GET1 APP OTOF SEC61B HMOX1 GET3 EMD GET4 CAMLG UBL4A PRNP DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 95%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 95%418990 Adherens junctions interactions ZNF217 STRAP HEYL ANGPTL4 TCF3 TGIF2 EED POMT2 POMT1 RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 ANG RPS27A ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C MDM2 FOXQ1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 95%9648025 EML4 and NUDC in mitotic spindle formation NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 NUP107 CENPO CENPP CENPQ EML4 SPC24 NUP160 SPC25 MAD2L1 CENPS NUP85 PLK1 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 NEK9 ZWINT NEK6 NEK7 KIF18A RPS27 AHCTF1 CLIP1 PPP2R5E G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 95%8964315 G beta:gamma signalling through BTK GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 BTK GNGT1 GNG8 GNGT2 GNG10 GNG12 GNG11 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation UBC TICAM2 TICAM1 RPS27A MAP3K7 LY96 TRAF6 UBA52 CD14 IRAK2 TAB1 TAB3 TAB2 UBB TLR4 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 95%9660821 ADORA2B mediated anti-inflammatory cytokines production GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 PRKACG PRKACA PRKACB GNAZ GNG3 ADORA2B GNG2 GNG5 GNG4 GNG7 GNG8 PRKAR1B PRKAR2B IL6 PRKAR1A PRKAR2A PRKX GNAI3 GNAI1 GNAI2 GNG10 GNG12 GNG11 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 95%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 95%69206 G1 S Transition ORC4 ORC6 ORC1 PCNA ORC3 ORC2 CDT1 CDC6 CDC25A LIN54 LIN37 LIN9 WEE1 LIN52 DHFR TK1 RB1 CDKN1B RRM2 E2F1 RBBP4 SKP2 CABLES1 FBXO5 TFDP1 CCNE2 TFDP2 CDK4 PRIM2 CCNE1 PRIM1 PPP2R1B POLA1 PPP2R1A POLA2 TYMS CKS1B MAX POLE AKT2 POLE4 POLE2 POLE3 PTK6 CDKN1A HDAC1 CDC7 CCND1 CDK2 CDC45 PPP2CA PPP2CB MCM10 MYC DBF4 RPA4 E2F4 E2F5 PSMD8 PSMD6 E2F6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 RBL1 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 CCNB1 PSMA2 UBA52 PSMD12 PSMD11 CDK1 PSMD14 PSMD13 PSMA7 PSMB6 CDK7 PSMB7 PSMB4 MNAT1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PPP2R3B PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 SKP1 CCNA2 CCNA1 MCM3 MCM4 MCM5 MCM6 MCM2 CUL1 AKT3 ORC5 SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 95%1236394 Signaling by ERBB4 SOS1 YAP1 HBEGF GFAP SPARC SHC1 PIK3R1 NRAS APH1A ITCH PSENEN NCSTN APH1B PSEN2 PSEN1 GABRG3 APOE GABRG2 GABRB3 GABRB2 GABRB1 NCOR1 CXCL12 ESR1 WWOX ADAM17 SRC NRG1 DLG4 STAT5A NEDD4 GABRQ EGF EGFR GABRA1 UBA52 STMN1 WWP1 ADAP1 CSN2 UBB UBC RPS27A MXD4 HRAS S100B TAB2 EREG NRG3 PIK3CA PGR NRG4 NRG2 BTC TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly COL17A1 ITGB4 LAMB3 CD151 ITGA6 PLEC DST LAMA3 LAMC2 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 95%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 95%9761174 Formation of intermediate mesoderm OSR1 FGF2 FOXC2 FOXC1 BMP4 PAX8 PAX2 LHX1 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 95%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex PDHB PDPR PDK4 PDK3 DLAT PDK2 PDK1 PDHX PDHA2 PDHA1 SIRT4 PDP1 GSTZ1 PDP2 DLD FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 95%6783310 Fanconi Anemia Pathway CENPX UBA52 MUS81 WDR48 SLX4 EME1 EME2 SLX1B FANCI UBB ATRIP FANCC UBC FANCD2 RPS27A DCLRE1B DCLRE1A FAAP100 UBE2T FAAP24 USP1 POLN FAAP20 FAN1 FANCM RPA1 FANCL FANCA RPA2 FANCB FANCE FANCG FANCF RPA3 ERCC4 ERCC1 ATR CENPS UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin EEF2 HBEGF HSP90AA1 CD9 HSP90AB1 TXNRD1 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 95%5621480 Dectin-2 family MUC15 MUC13 MUCL1 LYN MUC3A MUC5AC CLEC4C MUC3B CLEC4D MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 MUC5B MUC20 MUC21 CLEC10A CLEC4A CLEC4E CLEC6A SYK FYN PLCG2 MUC12 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EIF1AX RPL10 RPL12 RPL11 EIF3M RPL36A EIF3K RPL14 EIF3L RPL13 EIF3I RPL15 EIF3J RPL18 EIF3G RPL17 EIF3H RPL19 EIF3E RPL39L EIF3F RPL41 EIF3C RPL35A EIF3D RPL23A EIF3A RPL3L EIF3B RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 95%5627123 RHO GTPases activate PAKs CDC42 CTTN FLNA PPP1R12A PAK1 PAK3 LIMK1 RAC1 MYL12B MYL6 MYH9 MYLK MYH14 MYH11 MYH10 MYL9 NF2 PAK2 PPP1R12B PPP1CB CALM1 NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.2 NTRK2 activates RAC1 DOCK3 RAC1 NTRK2 BDNF DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.4 Defective SLC35D1 causes SCHBCKD SLC35D1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 95%9754678 SARS-CoV-2 modulates host translation machinery SNRPD2 SNRPD1 SNRPD3 SNRPB SMN2 GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 SNRPG RPS25 RPS28 RPS29 RPS20 FAU SNRPE RPS21 RPS24 RPS27 RPS23 SNRPF G2 PHASE%REACTOME DATABASE ID RELEASE 95%68911 G2 Phase E2F1 CDK2 E2F3 CCNA2 CCNA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.5 Metabolic disorders of biological oxidation enzymes FMO3 CYP17A1 CYP4F22 CYP19A1 TPMT CYP7B1 MAT1A CYP11A1 CYP2U1 CYP1B1 CYP27A1 CYP11B2 AHCY CYP27B1 CYP11B1 TBXAS1 SLC35D1 CYP26B1 GSS OPLAH CYP24A1 CYP26C1 CYP2R1 CYP21A2 GCLC GGT1 GCLM FDXR ACY1 MAOA UGT1A4 FDX1 FDX2 UGT1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA2 PPA1 LHPP SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 95%9842663 Signaling by LTK PIK3CB SOS1 ALKAL2 ALKAL1 LTK TNK2 PIK3R2 PIK3R1 GRB2 PIK3CA IRS1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 95%8964616 G beta:gamma signalling through CDC42 GNG13 CDC42 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 ARHGEF6 GNG7 GNGT1 GNG8 PAK1 GNGT2 GNG10 GNG12 GNG11 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 95%9945266 Differentiation of T cells IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME DATABASE ID RELEASE 95%2564830 Cytosolic iron-sulfur cluster assembly NDOR1 RTEL1 POLD1 ABCB7 MMS19 BRIP1 ERCC2 CIAO3 CIAO1 NUBP1 NUBP2 CIAO2B VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways RELA NPM1 ITCH NR3C1 IRAK1 TAF4B YWHAE PRR5 CHD4 YWHAQ YWHAG C4A YWHAH TBP EXOC1 EED TAF9 TAF1L MTA2 GBF1 TAF15 TAF12 TAF13 TAF11 REST TAF8 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 DNAJC3 MED1 RAC1 MED8 MED4 MED6 MED7 UBE2N VAV1 MAPKAP1 NEDD4L C4BPA C4BPB PTGES3 DNAJA2 FKBP4 C4B_2 HSPA1B IFNGR1 IFNGR2 IKBKB TAF7L FEN1 UBE2I SUMO1 C1QA C1S ELOB ELOC RBX1 VHL RNMT CCNH POLR2A ISCU POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CSNK2A1 CSNK2A2 CSNK2B NRBP1 TLR8 KPNA7 KPNA4 KPNA5 GBP1 KPNA3 CDK8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C PYCARD NUP42 NUP85 CLEC5A TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 RAB5B NUP153 RAB5C NUP93 NUP50 NUP35 NUP54 RBBP4 SLC25A5 SLC25A4 SLC25A6 NUP37 RBBP7 PPP1CC PML DYNC1LI1 DYNC1LI2 RPS27 ITGB1 DYNLL1 PARP1 BST2 RANGAP1 PRMT1 DYNLL2 CD33 CHUK TJP1 DYNC1I2 DYNC1I1 DYNC1H1 TAOK1 CASP1 CD300A DDX3X JAK2 CTDP1 DYNLT1 ELL CCNT1 SUPT4H1 ELOA NELFB MMP9 RRBP1 NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 HCK SYK LCK FYN SKP1 PROS1 F2 GAS6 CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 APOA1 IGHV3-23 ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 P4HB PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 BTRC JAK3 SIGMAR1 IGKV3D-20 IGHD MTA1 TLR7 IGKV2-30 MTA3 IGLV3-19 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X IGLV3-25 RPS15 IGLV3-27 RPS14 IGKC RPS17 IGKV1-39 RPS15A IGLV3-21 RPS16 IGKV1-33 RPS19 BRD4 RPS18 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 STAT2 RPS10 IGLC6 RPS13 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU UBE2L6 RPS21 RPS24 HERC5 RPS23 HLA-H HLA-B HLA-C ATG14 HLA-F HSP90AB1 HLA-G HLA-E ATG7 RPTOR CALR MLST8 EIF4E MRC1 GRSF1 MTOR FKBP1A TLR6 IKBKE IRF7 RAN NEK2 PDIA3 TUBB VPS36 VPS25 CBX1 SNF8 CHMP1A UBE2V1 CUL5 UBA7 UBA6 UBA5 UBR4 PAK2 IGF1R CAV1 UBA3 UBA1 ATP1B3 TGFB1 ATP1B2 ATP1B1 SEC23A FXYD4 FXYD3 HYOU1 FXYD2 FXYD1 FXYD7 FXYD6 SEC24B SEC24A ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 SEC24D ATP1A1 SEC24C TMPRSS2 SRPK2 ANO10 GALNT1 AXL RCC1 SUN2 VPS28 TSG101 VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MVB12B MVB12A RANBP1 UBAP1 NRP1 MASP1 XRCC6 XRCC4 XRCC5 LIG4 RPL4 RPL5 RPL30 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 HDAC2 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 SIKE1 RPL35A RPL23A GSK3B RPL3L CSNK1A1 RPL27A RPL22L1 RPL26L1 CDC73 SKIC8 CTR9 RTF1 LEO1 PAF1 ARID4B SAP30 CGAS CREBBP SP1 NFE2L2 NCL BCL2L1 PTPN6 IRAK2 CEBPD TAB3 TAB2 NFKBIB ELK1 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 CLEC4M IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 IFNA16 SAP30L IFNA17 BAG2 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 IL17F PARP9 IL17A PARP14 GEMIN2 PARP8 TUFM GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 CD14 P4HA3 DNAJC10 NMT1 VPS33B RIPK3 RAB5A KPNB1 TLR4 BCAP31 FNTA CHMP4C CHMP4B CHMP4A LY96 MLKL CHMP2B CHMP2A PDCD6IP CHMP3 CHMP6 CHMP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS SDC4 ZDHHC11 DDOST SDC2 SDC3 MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 GPC1 GPC3 GPC2 GPC5 RETREG1 GPC4 GPC6 KEAP1 H2AC17 H2AC12 TRIM25 SDC1 LYN BTK ARF1 NPLOC4 RPLP0 H2AC25 H2AC21 IFIH1 JAK1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TYK2 PPIA RNF135 TAF9B KPNA2 MAP3K7 H2AC1 SPCS3 VCP SPCS2 CLINT1 SPCS1 SEC11A SEC11C NLRP3 RIPK1 SUDS3 SMAD4 SMAD3 NFKBIA SCAP MAVS TAB1 RIGI GJA1 MERTK H2BC18 TRAF3 TRAF6 BECN1 NOD1 NOD2 EIF4E3 EIF4G3 TAF10 EIF4G2 NCK1 AKT2 PDPK1 EIF4A3 HNRNPU HNRNPR TLR9 PIK3C3 CCAR1 SNRPD2 SOS1 SNRPD1 CLP1 SNRPD3 SRRM2 PIK3R4 AQR PIK3R1 CRNKL1 CDC40 ATP6V1H DHX9 CSTF3 CSTF2 PCBP1 PCBP2 PTPN11 CSTF1 DHX38 SYMPK RBM10 TLR3 HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 DOCK2 CAMK2G HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 EFTUD2 PPP1CB CWC22 PAPOLA TXNL4A SNRPN ZCRB1 WBP11 SEM1 PRPF6 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 KDELR1 SNRPB SRSF9 DDX5 PRPF8 CLU CPSF4 CPSF1 FUS HSPA5 ALYREF CPSF3 CCR5 CXCR4 CPSF2 CWC15 COG1 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 TLR1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 TLR2 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW S1PR1 CDC5L U2SURP SNRNP40 PPIL3 PPIL4 CD4 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN HDAC1 CTNNB1 ACOT2 GRPEL1 YWHAB ELAVL1 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 SFN YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 CLDN1 PSMB6 PSMB7 PSMB4 PSMB5 UBB MED16 PSMB2 MED15 PSMB3 MED17 UBC MED12 PSMB1 MED14 MED13 RPS27A MED10 HSPA8 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MED27 HSPA1A MED26 EIF4G1 MED23 MED25 MED24 MED20 PEX19 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 FURIN BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 RICTOR CPSF7 ROCK1 ROCK2 CUL3 MBD3 SRRM1 STAT1 GATAD2B VIM GATAD2A HNRNPC RBMX ZBP1 AP1G1 AP1S2 AP1S1 AP1S3 TBK1 B2M IRF3 AP1M2 STING1 AP1M1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 CCNT2 PALS1 UVRAG MAP1LC3B HSP90AA1 EGFR RB1 FNTB DAXX NMT2 LIG1 H2AC19 H2BC26 H2AC14 H2BC21 EP300 IL6R H3C8 MED30 H2AC8 H2AC6 MED31 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 H3C15 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 NFKB1 H2AC20 SRPK1 HDAC3 KDM1A GPS2 TBL1X ITGA4 NCOR2 NCOR1 TBL1XR1 ST6GALNAC2 ST6GAL1 CCNK CCNC TRIM28 DPM1 DPM2 DPM3 ST6GALNAC3 ST6GALNAC4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 CTSL ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases ATP8A2 ATP8A1 ATP12A SLN ATP11C ATP1B3 ATP11B ATP11A ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 ATP7A ATP8B4 ATP8B3 ATP8B2 CAMK2B ATP8B1 SRI ATP4B CAMK2D ATP4A FXYD4 FXYD3 CAMK2A FXYD2 FXYD1 FXYD7 FXYD6 ATP2B4 CUTC ATP2B3 ATP2B2 ATP2B1 ATP7B CALM1 CAMK2G PDZD11 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 PLN ATP9B ATP9A ATP13A1 ATP13A4 ATP13A5 ATP13A2 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME DATABASE ID RELEASE 95%5688031 Defective pro-SFTPB causes SMDP1 and RDS SFTPB MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702600 midostaurin-resistant FLT3 mutants FLT3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 95%170670 Adenylate cyclase inhibitory pathway ADCY9 GNAL ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNAT3 GNAI3 GNAI1 GNAI2 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.3 Nervous system development CLTB YAP1 ARPC1B ARPC1A ARPC4 ARPC5 ARPC2 ARPC3 ACTR3 ACTR2 ETF1 GSPT2 GSPT1 UPF3A UPF2 LDB1 UNC5A UNC5B CAP2 SPTAN1 DAG1 MMP2 TRIO ITSN1 SDCBP RAC1 VAV3 ARHGEF11 ARHGEF12 PRKCQ CRMP1 DPYSL4 DPYSL5 VAV2 DPYSL2 DPYSL3 TIAM1 ARHGEF7 MAPK7 SOS2 NGEF KALRN APH1A PSENEN NCSTN APH1B CLTCL1 PSEN2 ADAM10 PSEN1 DNM1 RET SDC2 GPC1 MAG TEAD1 SHC3 DNM3 ELOB ELOC RBX1 CUL2 SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 LYN SIAH2 RPLP0 PITPNA CFL1 ACTB MSN PIK3CD CSNK2A1 CSNK2A2 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 POU3F1 ITGA1 ABL1 ISL1 PLXNA4 CDK5 USP33 FARP2 PLXND1 PTPRC ACTG1 PLXNA1 IRS2 PIK3CB PLXNB1 NCK2 NCK1 PFN1 PFN2 GRB10 NFASC HRAS SRGAP2 GAB1 FRS2 EIF4A3 GRB7 GAB2 PIK3CA PIK3R3 RPS27 ITGB1 SPTBN1 SOS1 MAGOH SHC1 PIK3R2 PIK3R1 RHOC NRAS RHOA RHOB MAPK1 EVL CDK5R1 ARHGEF28 MAPK3 CACNB1 PTPN11 CACNB3 CACNB4 CDC42 UPF3B MAGOHB CLASP1 CLASP2 SRC RNPS1 SHANK3 GRIN2B GRIN1 DLG1 RND1 DLG3 DLG4 MBP ADGRV1 TYROBP DOCK1 MPZ ADGRG6 HMGCR ERBB2 PRX PMP22 SOX10 CASC3 RANBP9 MMP9 NCBP1 TLN1 NRP2 NCBP2 CNTN2 NRCAM POU3F2 ANK1 SEM1 FYN CLTC CYP51A1 CLTA SREBF2 AP2A1 VLDLR AP2A2 RBM8A AP2M1 RAP1GAP PRKACG PRKACA CXCR4 PRKACB AP2S1 CXCL12 KIF4B AP2B1 KIF4A CAP1 TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 VASP SH3KBP1 LAMA2 LAMA1 LAMB1 LAMC1 NUMB ENAH RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 MYO10 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 SEMA4D RPS6 LIMK2 RPSA LIMK1 PRKAR2A MYL12B RPS3A MYL6 RPS26 MYH9 RPS25 PPP3CB MYH14 RPS28 SCD5 MYH11 RPS29 MYH10 CACNB2 RPS20 FAU RPS21 RPS24 EZR RPS23 CACNA1D ALCAM SCN11A HOXA2 UNC5C RDX HSP90AB1 UNC5D SCN10A AGAP2 FLRT3 CHL1 LYPLA2 ZSWIM8 NAB1 MSI1 COL6A2 NAB2 PLXNC1 MET SEMA6A COL4A4 SEMA6D SEMA7A DNM2 COL6A1 DAB1 COL4A3 LHX3 PTPRA LHX2 PLXNB3 SIAH1 LHX4 COL6A3 LHX9 EGR2 CNTNAP1 TREM2 COL4A5 NEO1 COL6A6 SPTB COL6A5 NTN4 SEMA3E SEMA4A NELL2 RPS6KA4 SCN1B SCN1A EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ANK2 PSMD8 ANK3 PSMD6 SHTN1 EPHA1 PSMD7 EPHA3 MYL9 SPTBN4 PSMD2 SPTBN5 EPHA10 PSMD3 SCN3B SCN3A PSMD1 SPTBN2 PRNP ARTN CD24 SCN2A SCN2B PRKCA ROBO2 GFRA1 PSMA5 GFRA3 PSMA6 KCNQ2 RGMB PSMA3 KCNQ3 GFRA2 PSMA4 EPHB6 RGMA PSMA1 GFRA4 EFNB2 RELN ARHGAP39 EFNB1 PSMA2 CD72 EFNB3 EPHB2 SCN9A EPHB1 PABPC1 ARHGAP35 NRTN UBA52 EPHB4 DOK2 EPHB3 DOK4 DOK5 PSMD12 DOK6 PSMD11 SCN8A PSMD14 CACNA1C ITGA10 EFNA5 PSMD13 EFNA4 SPTA1 PSMA7 CACNA1S GIT1 PSPN PSMB6 CNTN6 EFNA1 PSMB7 EFNA3 EFNA2 PSMB4 GDNF HJV PSMB5 SCN5A GAP43 UBB DCX PSMB2 SCN4A PSMB3 SCN4B SLIT1 UBC SCN7A PSMB1 SLIT3 PDLIM7 RPS27A EPHA2 HSPA8 ADRM1 PSMC5 PSMC6 PAK1 PSMC3 PSMC4 PSMC1 CACNA1H PSMC2 MYL12A ABL2 CACNA1G EIF4G1 CACNA1I PAK2 PAK4 DRP2 ROCK1 ROCK2 CNTN1 UTRN DSCAM DCC DSCAML1 NTN1 NCAN RPS6KA6 SRGAP3 HSP90AA1 SRGAP1 EGFR PLCG1 WASL DOK1 RASA1 PAK6 PAK3 PAK5 MYO9B NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B L1CAM ITGAV COL4A2 NCAM1 ITGA5 COL4A1 ITGA9 RPL4 RPL5 RPL30 RPL3 RPL32 ITGA2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 COL9A1 RPL37 COL9A3 COL9A2 RPL39 AGRN RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 HDAC2 RPL29 SEMA5A RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 AKAP5 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 ST8SIA4 SH3GL2 WWTR1 YES1 SMARCA4 ST8SIA2 ABLIM1 ABLIM2 ABLIM3 PTK2 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 95%180534 Vpu mediated degradation of CD4 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 CD4 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 PSMD3 PSMD1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism SLC26A2 CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC CUBN AMN ABCD4 LMBRD1 GSS OPLAH GCLC GGT1 GCLM ACY1 SFTPD PPM1K AUH IVD HIBCH FMO3 GALM ADAMTS13 MAT1A POMT2 CYP2U1 G6PC3 POMT1 CYP1B1 POMGNT1 B4GAT1 AHCY DAG1 SLC35D1 LARGE1 APRT PNP ACACA HPRT1 FDXR ADA MAOA GALK1 CHSY1 GALE PRELP CHST6 OMD FDX1 KERA FDX2 NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 ACAT1 SFTPA2 MGAT2 PAPSS2 MOGS SDC4 SDC2 SDC3 B3GAT3 CYP27B1 SGSH CYP26B1 CYP24A1 CYP26C1 CYP21A2 CYP2R1 NAGLU B4GALT1 MAN1B1 ECHS1 GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 IDH1 UBA52 CYP4F22 CYP19A1 UBB TALDO1 UBC TBXAS1 RPS27A MMAA MMUT SFTPC PAH SRD5A3 MCCC2 BTD PC GBE1 PCCA HLCS MCCC1 GYS2 PCCB GYG2 EPM2A GNS PPP1R3C NHLRC1 CYP27A1 GALT B3GALT6 SLC37A4 B4GALT7 MMAB IDUA NCAN HEXB HEXA BGN DCN BCAN MTRR VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB GYG1 CYP17A1 GYS1 CYP7B1 PGM1 TCN2 CD320 CBLIF MMACHC MMADHC MUC13 G6PC1 SFTPB SFTA3 CHST14 SFTPA1 TPMT DCXR HSPG2 CYP11A1 GAA ACAN CYP11B2 LUM AGRN FMOD ABCA3 GALNT12 SEMA5A DPAGT1 SPON2 SEMA5B SPON1 THSD7B MPI MTR ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 CSF2RB THSD7A CSF2RA ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 ADAMTS12 DPM1 DPM2 THSD1 POMC ALDOB DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 SI MUC1 LCT MUC2 ADAMTS19 HGSNAT GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 CYP11B1 NEU1 SSPOP KHK MUC5B MUC20 MUC21 GALNS LFNG ST3GAL3 MPDU1 CTSA NUS1 UGT1A4 PMM2 GFPT1 DOLK SLC34A2 UGT1A1 BCKDK BCKDHA BCKDHB MC2R DBT DLD SLC25A15 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling LIFR CRLF1 TYK2 IL6ST STAT3 CBL SOCS3 IL6R LIF IL11 OSM IL6 OSMR IL31 CNTFR CNTF IL11RA JAK2 JAK1 IL31RA STAT1 CTF1 PTPN11 CLCF1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.4 FGFRL1 modulation of FGFR1 signaling FGF18 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 SPRED2 SPRED1 FGFRL1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 95%199992 trans-Golgi Network Vesicle Budding CLTC CLTB FTH1 CLTA FTL CTSZ BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 GNS SNAPIN AP3S1 TPD52 CLINT1 DNM2 AP4S1 AP4M1 AP1G2 SH3D19 DNAJC6 PIK3C2A AP1G1 AP1S2 AP1S1 AP1S3 HIP1R AP1M2 TPD52L1 AP1M1 AP1B1 NECAP1 PICALM SNX2 SNX9 VAMP8 SNX5 TBC1D8B PUM1 AP4E1 M6PR GAK ARRB1 SORT1 YIPF6 AP4B1 TFRC ACBD3 STX4 SNAP23 DNASE2 CLVS2 IGF2R CLVS1 DTNBP1 ARF1 GOLGB1 NAPA RAB5C GBF1 TGOLN2 AP3B1 TXNDC5 HGS OCRL CPD VAMP7 SH3GL2 HSPA8 VAMP2 APP CHMP2A TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 95%2173793 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer NEDD4L SERPINE1 FURIN PARP1 HDAC1 MAPK1 SKIL MAPK3 ATP1B4 SKI CDK8 NCOR2 SMAD2 SMAD4 YBX1 NCOR1 SMAD3 SMURF2 SMAD7 SNW1 MYC E2F4 CCNT2 PPM1A E2F5 UBE2D3 RBL1 TGIF1 UBE2D1 TGIF2 TRIM33 CCNK CCNC UBA52 CDKN2B COL1A2 CCNT1 TFDP1 TFDP2 UBB UBC SP1 RPS27A CDK9 EP300 JUNB RNF111 MEN1 WWTR1 USP9X BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 95%2025928 Calcineurin activates NFAT FKBP1A NFATC2 NFATC3 PPP3CA PPP3CB NFATC1 PPP3R1 CALM1 PPIA GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.2 GLI3 is processed to GLI3R by the proteasome PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 SUFU BTRC PSMD13 PRKACG PSMA7 PRKACA PSMB6 PRKACB PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 GLI3 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 SKP1 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CUL1 CSNK1A1 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS C1GALT1 MUC15 MUC19 MUC5B MUC20 MUC21 MUCL1 MUC13 MUC3A MUC5AC MUC3B MUC1 C1GALT1C1 MUC2 MUC7 MUC4 MUC6 MUC16 MUC12 MUC17 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-HSA-9764725.1 Negative Regulation of CDH1 Gene Transcription ZNF217 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 HDAC1 H2AC20 KDM1A TLE1 MAPK1 MAPK3 HDAC2 FOXQ1 SUZ12 TCF3 ZMYM2 TCF12 DNTTIP1 ZBTB33 MCRIP1 SNAI2 KMT5A TGIF2 EED RBBP4 EZH2 MPHOSPH8 ZEB2 RBBP7 SNAI1 CTBP2 CTBP1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 H3-3B WT1 H3C8 H2AC8 H2AC6 ZEB1 H2AC7 H2BC17 H2BC12 SMARCA4 H2BC13 H2BC14 SIRT1 H2AJ H2BC15 TWIST2 H2BC11 TWIST1 H3C15 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor GRIK5 DLG1 GRIK3 GRIK4 NCALD GRIK1 DLG3 GRIK2 DLG4 CALM1 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 95%69580 p53-Dependent G1 S DNA damage checkpoint CDKN1A CDKN2A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 PSMB5 CCNE1 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 ADRM1 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 TP53 CCNA1 ATM DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 95%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein GANAB CANX MGAT1 PRKCSH MOGS RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SNAPC5 SNAPC1 SNAPC2 SNAPC3 CCNT2 SNAPC4 ZNF143 PCF11 POU2F1 POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E SRRT POLR2F POLR2G POLR2H TAF9 POLR2I POLR2J POLR2K POLR2L TAF13 SUPT5H GTF2F1 TAF11 GTF2F2 ELL CDK7 CCNT1 TAF8 SUPT4H1 TAF6 TAF5 NCBP1 NCBP2 SP1 INTS1 INTS3 INTS2 CDK9 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 GTF2A1 ICE1 GTF2A2 ICE2 GTF2B SSU72 GTF2E1 GTF2E2 NABP2 NABP1 PHAX ELL2 ELL3 ZC3H8 RPRD2 RPAP2 RPRD1B RPRD1A POU2F2 BETA DEFENSINS%REACTOME DATABASE ID RELEASE 95%1461957 Beta defensins DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB1 DEFB104B DEFB109B DEFB136 DEFB135 DEFB134 CCR6 DEFB133 DEFB132 DEFB108B DEFB108C CCR2 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A DEFB130B DEFB4B TLR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion CACNA1D GNG13 GNB2 GNAQ KCNJ11 GNB1 ABCC8 GNB4 GNB3 STXBP1 INS GNB5 ADCY8 GNGT1 ADCY6 ADCY5 GNGT2 RAP1A SLC2A1 PRKACG SLC2A2 PRKACA ADRA2C PRKACB RAPGEF3 SYT5 FFAR1 ADRA2A RAPGEF4 CACNB3 GNA14 CACNA1A CACNA1E STX1A GNG3 GNA15 ITPR1 ITPR2 GNG2 ITPR3 GNG5 GNG4 GNG7 GNA11 GNG8 KCNG2 AKAP5 GNAI1 GNAI2 PRKCA IQGAP1 CD36 SNAP25 GNAS KCNC2 GCG CACNA1C CHRM3 GLP1R KCNB1 KCNS3 VAMP2 PRKAR1B PRKAR2B PRKAR1A AHCYL1 PRKAR2A CACNA2D2 MARCKS CACNB2 PLCB3 PLCB1 PLCB2 GNG10 ACSL4 ACSL3 GNG12 GNG11 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome KCNJ11 ABCC9 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.2 ATF6B (ATF6-beta) activates chaperones HSPA5 MBTPS1 ATF6B MBTPS2 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM6 IRF1 NCAM1 TRIM5 IRF2 TRIM2 TRIM3 GBP1 CIITA HLA-H TRIM68 TRIM62 HLA-B TRIM46 HLA-C TRIM48 TRIM45 HLA-F TRIM35 HLA-G TRIM38 HLA-E OAS2 TRIM31 TRIM34 MAPK1 FCGR1BP IFI30 RAF1 TRIM29 TRIM26 TRIM22 MAPK3 MT2A TRIM17 SOCS1 PTPN1 IFNGR1 TRIM14 VCAM1 IFNGR2 TRIM10 PTPN11 SP100 CD44 MID1 YBX1 IRF8 B2M IRF6 IRF3 IRF9 SMAD7 CAMK2B PIAS1 HLA-A CAMK2D SUMO1 TRIM21 GBP5 CAMK2A GBP2 GBP6 GBP4 GBP3 TRIM25 IRF7 FCGR1A CAMK2G PRKCD IFNG PTAFR OASL OAS1 OAS3 HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 JAK2 HLA-DRB4 JAK1 HLA-DPB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 PML HLA-DQB1 ICAM1 SOCS3 PTPN6 IRF4 IRF5 GBP7 TRIM8 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME%R-HSA-9932444.2 ATP-dependent chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%947581 Molybdenum cofactor biosynthesis GPHN MOCS2 MOCS3 MOCOS UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME%R-HSA-381119.4 Unfolded Protein Response (UPR) ATP6V0D1 SRPRB TPP1 PREB CXXC1 CXCL8 HDGF PPP2R5B KDELR3 SHC1 CREB3L3 ADD1 DCTN1 HSPA5 NFYA NFYB NFYC ATF6 CEBPB HERPUD1 CEBPG CCL2 ASNS SEC31A EIF2S2 EIF2S1 ERN1 EIF2S3 DDIT3 CREB3 CREB3L4 CREB3L1 ATF3 CREB3L2 ATF4 CALR EXTL2 MBTPS1 CREBRF DCSTAMP ATF6B MBTPS2 PLA2G4B EXTL3 HYOU1 KHSRP GSK3A EIF2AK3 DIS3 ACADVL PDIA6 DNAJB11 DCP2 SERP1 PARN WFS1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 TLN1 EXOSC8 DNAJC3 EXOSC3 EXOSC2 EXOSC1 CUL7 FKBP14 IGFBP1 GOSR2 MYDGF EXTL1 TATDN2 LMNA SSR1 DNAJB9 SULT1A3 TSPYL2 ZBTB17 GFPT1 KLHDC3 DDX11 WIPI1 EDEM1 YIF1A ARFGAP1 SYVN1 PDIA5 HSP90B1 CTDSP2 SRPRA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME DATABASE ID RELEASE 95%9657688 Defective factor XII causes hereditary angioedema KLKB1 F2 F12 MRNA 3'-END PROCESSING%REACTOME DATABASE ID RELEASE 95%72187 mRNA 3'-end processing SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A CPSF4 CHTOP CPSF7 CPSF1 FUS ALYREF CPSF3 CPSF2 SRRM1 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 LUZP4 POLDIP3 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 MAGOH SNRPD3 SRRM2 CDC40 DDX39A ZC3H11A SARNP DHX9 DDX39B CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 UPF3B MAGOHB HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SLU7 SF3B4 FYTTD1 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 CASC3 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 95%176409 APC C:Cdc20 mediated degradation of mitotic proteins BUB3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 MAD2L1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CCNB1 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 CDK1 ANAPC4 NEK2 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 BUB1B PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 CCNA1 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors GNG13 GNB2 GNB1 GRIK3 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 95%9819196 Zygotic genome activation (ZGA) YAP1 CREBBP DPPA4 DPPA2 LEUTX KDM4E EP300 TPRX1 TPRX2 ZSCAN4 TEAD4 TUT7 TUT4 DUX4 TP53 TPRXL DUXA DUXB AMINO ACID AND DERIVATIVE METABOLISM%REACTOME%R-HSA-71291.10 Amino acid and derivative metabolism CPS1 ARG1 ASL NAGS ASS1 NMRAL1 OTC NQO1 SRR SDS PSAT1 SERINC1 PHGDH SERINC3 PPM1K SDSL AUH IVD QDPR SERINC2 IL4I1 PSPH HIBCH SERINC5 PCBD1 ASRGL1 SERINC4 HNMT SEPHS2 KGD4 RARS1 SECISBP2 MAT1A LARS1 HGD NNMT TAT FAH EEFSEC HPD AIMP1 AIMP2 RPS4Y2 SEPSECS QARS1 RPS27L RPS4Y1 PSTK RPS4X MARS1 RPS15 INMT RPS14 DARS1 RPS17 SARS1 HSD17B10 EEF1E1 RPS15A RPS16 AHCY RPS19 KARS1 RPS18 CBS RPS3 IARS1 RPS2 GNMT SLC3A2 RPS11 CTH SCLY RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 SLC36A4 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 APIP RPS20 SLC6A12 HAL FAU RPS21 CARNMT1 RPS24 SLC7A5 UROC1 RPS23 AMDHD1 HDC CARNS1 FTCD CGA FMO1 ACAT1 PAPSS2 PAPSS1 ASNS TPH1 PIPOX EPRS1 ECHS1 PSMD8 PSMD6 PSMD7 HAO1 PSMD2 PSMD3 PSMD1 DIO1 DIO2 TXNDC11 DIO3 SLC5A5 DUOX1 TPO GCSH PSMA5 IYD PSMA6 DUOXA1 PSMA3 DUOXA2 PSMA4 DUOX2 PSMA1 DAO TSHB PXMP2 PSMA2 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RPS27A MTAP SLC25A12 AGXT PHYKPL SLC25A13 ADRM1 PAOX PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DDO TP53 CAV1 GCDH PAH HYKK TPH2 AADAT ASMT SLC25A21 AANAT CRYM AASS DHTKD1 MCCC2 AFMID MCCC1 RIDA BCAT1 AGXT2 BCAT2 SLC45A2 ALDH6A1 KYAT3 HIBADH KMO OGDH FOLH1 FOLH1B ASPG NAALAD2 NAT8L ASPA ACMSD TMLHE SHMT1 BBOX1 ALDH9A1 PNMT HAAO GRHPR DDC TDO2 TH IDO2 DBH IDO1 SLC25A44 MTRR DLST SLC44A1 GLDC HOGA1 OCA2 AMT TXNRD1 KYNU ODC1 AMD1 OAZ1 SAT1 OAZ2 SRM OAZ3 AZIN2 AZIN1 AGMAT CKMT2 GAMT SMS GATM SLC6A7 GOT1 SLC6A8 CKM CKMT1B SLC6A11 CKB RPS27 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 DMGDH RPLP1 RPL34 CHDH RPL10L SARDH RPL8 ALDH7A1 RPL10A RPL6 RPL7 ARG2 ALDH4A1 PRODH SLC25A2 RPL7A RPL18A PRODH2 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 MTR RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MRI1 ENOPH1 BHMT2 BHMT OAT ADI1 GLS2 GOT2 PYCR1 MPST TSTD1 PYCR2 PYCR3 SQOR GLS GADL1 GLUD1 SUOX GLUD2 ADO KYAT1 CSAD RIMKLA TXN2 GLUL TST ETHE1 RIMKLB SLC25A10 CDO1 GSTZ1 ACADSB ACAD8 TYR SIRT5 DCT SEM1 TYRP1 GPT BCKDK BCKDHA BCKDHB DBT DLD SLC25A15 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 95%606279 Deposition of new CENPA-containing nucleosomes at the centromere H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 95%2187335 The retinoid cycle in cones (daylight vision) OPN1MW OPN1LW DHRS3 OPN1SW RBP3 AWAT2 RLBP1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 95%9854311 Maturation of TCA enzymes and regulation of TCA cycle CS ISCA2 ISCA1 ACO2 FXN ACAT1 LYRM4 SDHAF2 SDHAF3 SDHAF1 CSKMT SDHAF4 IDH2 SDHC SDHD SIRT3 SDHA SDHB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation MAPKAPK3 MAP3K7 IRAK1 UBE2V1 MAPKAPK2 TRAF6 MAPK14 MAPK11 IRAK2 TAB1 TAB3 TAB2 NOD1 MAP2K6 NOD2 UBE2N IKBKG MAP2K3 RIPK2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 95%75876 Synthesis of very long-chain fatty acyl-CoAs HACD1 ACSBG1 TECR HSD17B3 SLC27A3 HSD17B12 ACSBG2 HACD3 HACD2 HACD4 ELOVL1 ELOVL4 ACSL1 ELOVL5 ELOVL2 ELOVL3 ACSL6 ACSL5 ELOVL6 ACSL4 ELOVL7 ACSL3 TECRL ACSF3 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER PCNA PARP1 UBA52 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 ERCC3 ERCC2 UBB UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 DDB2 POLD2 POLE RFC2 RFC1 PARP2 RPA1 CHD1L RPA2 DDB1 XPA POLE4 CUL4A RPA3 RBX1 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 GCN1 RPS19 RPS18 EIF2AK4 RPS3 RPS2 RPS11 IMPACT RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 TRIB3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A CEBPB RPL6 RPL7 CEBPG ASNS RPL7A RPL18A EIF2S2 ATF2 RPL36AL EIF2S1 RPL36 EIF2S3 DDIT3 RPLP2 RPL35 RPL38 RPL37 ATF3 ATF4 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 RPLP0 RPS27A WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME%R-HSA-3238698.3 WNT ligand biogenesis and trafficking WNT5B WNT5A PORCN WNT7B WNT16 WNT1 WNT7A SNX3 WNT3A WNT9A WNT3 WNT8A WNT8B WNT10B WNT9B WNT6 WNT4 WNT2 WNT2B WNT10A VPS29 WNT11 VPS35 WLS VPS26A TMED5 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 95%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB2 VDAC1 MAIP1 PARL AFG3L2 LETM1 SMDT1 YME1L1 PMPCB PMPCA MICU3 AKAP1 MICU2 MICU1 MCU PHB1 SLC8B1 SLC8A3 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction PDE6G GNB1 GNGT1 APOA2 APOA1 APOA4 HSPG2 APOE SDC4 SDC2 SDC3 LPL RBP4 RDH12 OPN1LW RBP1 LRAT LDLR AGRN STRA6 GPIHBP1 GPC1 APOC3 APOC2 RDH5 GPC3 RLBP1 LRP8 GPC2 GPC5 GPC4 GPC6 OPN1MW APOB RPE65 SDC1 CALM1 PRKCA RDH8 OPN1SW GUCY2D GUCA1B GUCA1A GUCA1C LRP1 GUCY2F NMT1 RETSAT GRK1 APOM GRK7 FNTB RHO BCO2 CNGA1 BCO1 GNAT1 RCVRN AKR1B10 CAMKMT CLPS RBP2 RGS9BP SLC24A1 SAG LRP10 NMT2 LRP12 RBP3 PPEF1 PNLIP HSD17B6 METAP1 METAP2 CNGB1 HSD17B1 FNTA AKR1C1 TTR RDH11 RDH10 ABCA4 AKR1C4 RDH16 AKR1C3 SDR9C7 DHRS3 MYO7A DHRS9 PRKCQ LRP2 PLB1 CYP4V2 AWAT2 PDE6B PDE6A CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CALM1 CAMK2G ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.5 Acyl chain remodelling of PS PLA2G2D OSBPL10 PLA2G2E MBOAT1 PLA1A PLA2G5 PLA2R1 PLA2G10 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLAAT3 PLA2G2A OSBPL8 PLA2G1B OSBPL5 LPCAT4 LPCAT3 PLA2G2F PLA2G4A AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling HRAS SOS1 HBEGF TGFA AREG EGF EGFR NRAS EREG BTC EPGN DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 95%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 MAP2K4 MAP3K7 IRAK1 UBE2V1 TRAF6 MAPK9 IRAK2 TAB1 MAP2K7 MAPK10 MAPK8 TAB3 TAB2 NOD1 NOD2 UBE2N IKBKG RIPK2 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 95%157579 Telomere Maintenance H2BC9 ACD TINF2 PCNA H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 RUVBL1 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 WRAP53 CDK2 FEN1 PIF1 GAR1 CTC1 RUVBL2 POLR2A POLR2B POLR2C POLR2D NHP2 POLR2E POLR2F ANKRD28 POLR2G NOP10 POLR2H POLR2I POLR2J POLR2K PPP6C POLR2L PPP6R3 BLM RTEL1 CHTF8 DAXX ATRX WRN PRIM2 PRIM1 H2AX POLA1 DSCC1 POLA2 SHQ1 LIG1 DKC1 H2AB1 RFC5 H2AC19 POLD3 H2BC26 RFC3 POLD4 H2AC14 RFC4 POLD1 H2BC12L POLD2 CHTF18 H2BC21 RFC2 TERT RFC1 H3-3B STN1 RPA1 TEN1 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ RPA3 H2BC15 CCNA2 CCNA1 H2BC11 DNA2 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BRD7 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL7A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 SMARCE1 ACTB ARID2 PBRM1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3656532 TGFBR1 KD Mutants in Cancer TGFBR2 SMAD2 SMAD3 TGFB1 TGFBR1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome BCL2 BCL2L1 NLRP1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 95%416993 Trafficking of GluR2-containing AMPA receptors PRKCA TSPAN7 AP2A1 GRIA1 GRIA2 PRKCB GRIP1 NSF PICK1 PRKCG GRIP2 GRIA3 GRIA4 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.2 Defective factor IX causes thrombophilia F9 F10 F8 RSK ACTIVATION%REACTOME%R-HSA-444257.5 RSK activation RPS6KA1 MAPK1 RPS6KA6 PDPK1 MAPK3 RPS6KA3 RPS6KA2 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013405 RHOD GTPase cycle ARHGAP26 AKAP12 HINT2 VANGL1 ARHGAP32 PIK3R2 PIK3R1 RHOD ESYT1 ACTN1 LMNB1 TOR1AIP1 ARHGAP12 DBN1 CPNE8 STEAP3 ANKFY1 GOLGA8R MOSPD2 ADD3 ARHGAP1 SLC4A7 ARHGAP39 ARHGAP5 ARHGAP35 FILIP1 STBD1 EMD LBR TMPO VRK2 PLXNA1 LEMD3 DEPDC1B PLXNB1 CAPZB VAMP3 EFHD2 RAB7A ARHGAP17 ARHGAP21 PAK6 LMAN1 WHAMM PGRMC2 PAK5 RACGAP1 VAPB DIAPH1 DIAPH3 CAV1 MCAM CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 95%5660668 CLEC7A inflammasome pathway RELA MALT1 CASP8 NFKB1 IL1B PYCARD INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 95%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 CPSF4 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 95%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA DHTKD1 DLST DLD SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 95%9762292 Regulation of CDH11 function CDH24 ADAM33 ADAM19 CTNNB1 CDH11 JUP ANGPTL4 CTNND1 CDH8 CTNNA1 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance APOA1 HDLBP CUBN AMN MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase LMNB1 NCAPG2 SMC4 SMC2 NCAPH2 NCAPD3 MCPH1 NUP205 POM121 NUP107 NUP188 KMT5A AAAS NUP160 POM121C ARPP19 NUP42 NUP85 TPR ENSA NUP62 BANF1 NUP88 USO1 NUP43 RAE1 NDC1 RANBP2 SEC13 RAB2A NUP155 NUP133 RB1 NUP210 VRK1 LEMD2 NUP153 NUP93 NUMA1 NUP50 NUP35 NUP54 RAB1A RAB1B GOLGA2 NUP37 BLZF1 PPP2R1B H2AX CNEP1R1 PPP2R1A H2AB1 MASTL H2AC19 GORASP2 H2BC26 GORASP1 H2AC14 PPP2R2D H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 MAPK1 PPP2CA PPP2CB LPIN1 LPIN2 LPIN3 NUP214 PRKCA PLK1 CCNB1 CDK1 SET EMD LEMD3 CCNB2 NEK9 NEK6 NEK7 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956553.1 OTC main chain variants cause OTC deficiency OTC TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes PCNA PLK3 CDKN1A PRMT1 PLAGL1 NPM1 RGCC PLK2 CDK2 BTG2 CNOT4 CNOT6 CNOT7 CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 E2F4 CNOT9 CNOT11 E2F7 E2F8 RBL2 ZNF385A RBL1 SFN CCNB1 CDC25C CDKN1B AURKA ARID3A CDK1 BAX E2F1 CARM1 TFDP1 CCNE2 TFDP2 CCNE1 CPAP PCBP4 EP300 CNOT6L CCNA2 TP53 CCNA1 GADD45A CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC4 ORC6 ORC1 ORC3 MCM8 ORC2 CDC6 ORC5 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination H2BC9 PEX10 UBE2A PCNA PEX12 H2BC8 H2BC5 PEX13 UBE2W H2BC3 PEX14 H2BC1 USP7 HLA-B USP5 UBA1 RNF20 UBE2K CDC34 VCP UBE2J2 UBE2Q2 UBE2R2 DERL1 HLA-A UBE2D2 UBE2D3 RRAGA UBE2G1 UBE2G2 UBE2C CDC73 UBE2L3 UBE2E1 UBE2D1 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS UBE2S WAC UBA52 PRKDC CTR9 RTF1 BCL10 UBE2Z TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 UBE2E3 PEX2 UBB UCHL3 UBC RPS27A UBE2T OTULIN UBA6 UBE2V2 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 USP9X H2BC11 UBE2H UBE2B UBE2N RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 95%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 PAX5 ELF1 ELF2 CBFB BLK HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly APOA1 PRKACG A2M PRKACA PRKACB ABCA1 ZDHHC8 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 95%5654738 Signaling by FGFR2 SOS1 PIK3R1 NRAS FGF20 MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 PPP2CA FGF18 PPP2CB FGF10 PTBP1 HNRNPM HNRNPF HNRNPH1 POLR2A POLR2B POLR2C POLR2D POLR2E CBL POLR2F ESRP1 POLR2G POLR2H UBA52 PLCG1 POLR2I POLR2J POLR2K RBFOX2 POLR2L FGFBP3 FGFBP1 FGFBP2 GTF2F1 GTF2F2 TIA1 ESRP2 TIAL1 BRAF UBB PPP2R1A NCBP1 NCBP2 UBC FGF1 FGF2 FRS3 FGF3 RPS27A FGF4 HNRNPA1 FGF6 FGF7 FGF9 MKNK1 SPRY2 HRAS GAB1 FRS2 PIK3CA FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 95%9607240 FLT3 Signaling SOS1 STAT5A STAT5B CBL PIK3R1 NRAS UBA52 CDKN1B GRAP2 PTPRJ CSK BCL2L11 FLT3 UBB PTPN11 UBC RPS27A AKT2 GRB10 HCK SYK HRAS LCK FYN SLA ABL2 SLA2 SOCS2 SOCS6 FOXO3 SH2B3 FLT3LG AKT1 GAB2 PIK3CA AKT3 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 95%5632681 Ligand-receptor interactions HHIP BOC GAS1 SHH IHH DHH CDON PTCH1 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013419 RHOT2 GTPase cycle TRAK1 TRAK2 RHOT2 RAP1GDS1 MFN1 MYO19 MFN2 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193807.3 Synthesis of bile acids and bile salts via 27-hydroxycholesterol RXRA NCOA2 AKR1C1 AKR1C2 AKR1C4 CYP8B1 AKR1C3 CYP7B1 AKR1D1 NR1H4 NCOA1 CYP7A1 CYP27A1 HSD3B7 LEISHMANIA PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 95%9664417 Leishmania phagocytosis BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) LTC4S PTGR1 HPGD ALOX5AP ALOX12 ALOX5 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 95%1236978 Cross-presentation of soluble exogenous antigens (endosomes) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 PSMD11 PSMD14 FCGR1BP PSMD13 PSME1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 CD207 MRC2 ADRM1 PSME2 MRC1 PSMC5 PSMC6 SEM1 PSMC3 PSMB10 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 FCGR1A PSMD1 PSMB8 PSMB9 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380259 Loss of Nlp from mitotic centrosomes CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 95%167060 NGF processing FURIN PCSK6 NGF PCSK5 THE ACTIVATION OF ARYLSULFATASES%REACTOME DATABASE ID RELEASE 95%1663150 The activation of arylsulfatases ARSB ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD STS ARSA SUMF2 SUMF1 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 95%5578999 Defective GCLC causes HAGGSD GCLC GCLM PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PIP5K1C CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 PIK3R1 FGF9 FGF20 FGF23 FGF22 GAB1 FRS2 PIK3CA PTPN11 DISEASE%REACTOME%R-HSA-1643685.19 Disease SLC26A2 SLC22A5 ABCB6 ABCB4 SEL1L SLC5A1 SLC5A2 SLCO1B1 SLCO1B3 ERLIN1 ERLIN2 CP SLC6A5 SLC2A9 SLC26A4 RNF185 SLC26A3 ABCD4 SLC40A1 SLC2A1 SLC2A2 SLC6A2 SLC6A3 SLC22A12 HEPH ABCC2 AVPR1B SLC2A10 ABCC6 AVPR2 AVPR1A LMBRD1 SLC24A4 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 SLC17A8 SLC12A3 SLC16A1 SLC12A1 RHAG SLC24A5 EXOC1 GBF1 POMT2 CYP2U1 POMT1 CYP1B1 POMGNT1 B4GAT1 DAG1 LARGE1 FGFR2 OGG1 RAC1 VAV3 UBE2N VAV1 VAV2 CHST3 ACAT1 DCTN1 PTGES3 MAPK8 BCL2L11 DNAJA2 FKBP4 HSPA1B BAD IFNGR1 IFNGR2 B3GAT3 IKBKB SQSTM1 CYP27B1 MYD88 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FEN1 UBE2I SUMO1 UBE2D2 ELOB ELOC RBX1 VHL RNMT CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 ACTB CSNK2A1 CSNK2A2 CSNK2B TP53 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 SLC37A4 GNG2 GNG5 GNG4 GNG7 GNG8 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 ACTG1 PPP1CC PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DVL1 DVL2 DVL3 RPS27 ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C CARS1 DYNLL1 RANGAP1 DYNLL2 EEF1G DCXR CHUK DYNC1I2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 TAOK1 TFG MPRIP FGFR1OP2 SND1 ZC3HAV1 EIF2AK3 NOX4 ATIC DUSP8 DUSP9 MRAS KDR FAM114A2 PORCN MCL1 QKI NF1 KIAA1549 DUSP10 ESRP1 BIRC6 TRIM24 FXR1 BCL11A GOLGB1 IL22 HIP1 AGTRAP AP3B1 SHOC2 AGGF1 NFKB2 CPSF6 SI TENT4A LCT SPRED3 CTDP1 SPRED2 ELL SPRED1 CCNT1 MYO18A SUPT4H1 ELOA LRRFIP1 NELFB KANK1 RRBP1 ETV6 WDCP NELFCD NELFA FAM131B GOLGA4 NELFE BIN2 STRN SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 IPO5 LFNG JAG1 DLL1 SKP1 CUL1 NTRK3 NTF3 NEURL1B HES5 MIB2 RAP1B MIB1 RAP1A HEYL PRKACG NEURL1 RAF1 IGHV3-23 PRKACA PRKACB ARID4A IGLV COMT IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 ACE2 BRMS1 IGKV2D-28 IGKV4-1 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 IGHV1-69 PHF21A CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 RCOR1 IGKV3-20 IGHM SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 BLNK HMG20B IGLC1 VTN IGLC2 JAK3 SIGMAR1 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 G6PC3 RPS4Y2 IGHV2-70 RPS27L IGHV2-5 IGLV3-1 RPS4Y1 IGHV3-48 RPS4X RPS15 IGLV3-25 RPS14 IGLV3-27 IGKC RPS17 IGKV1-39 RPS15A RPS16 IGLV3-21 IGKV1-33 RPS19 RPS18 BRD4 CRBN RPS3 IGLC7 RPS2 IGHV3-53 RPS11 HNRNPA1 IGKV5-2 RPS10 STAT2 RPS13 IGLC6 IGKV1-5 RPS12 RPS9 IMPDH1 RPS7 IMPDH2 PDCD1 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 MYH9 RPS25 RPS28 RPS29 PRELP CHST6 RPS20 OMD FAU KERA RPS21 UBE2L6 RPS24 HERC5 RPS23 OGN NOTCH2 NOTCH3 NOTCH1 NOTCH4 HBEGF GCKR GCK HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E SFTPA2 RNF213 ATG7 SEC31A RPTOR CALR MLST8 EIF4E TSC2 MRC1 GRSF1 MTOR FKBP1A TLR6 AKT1S1 CYFIP1 NCKAP1 BRK1 PDIA3 S100A1 VPS36 CYBA VPS25 CBX1 SNF8 BCR CHMP1A LMO7 RAB7A UBE2V1 NOXO1 CUL5 UBA7 UBA6 UBA5 UBR4 NCKAP1L WASF1 PAK2 WASF2 CAV1 ERBIN BAIAP2 ABI2 NOXA1 UBA3 ABI1 UBA1 NOX1 TGFB1 TGFBR1 TGFBR2 LMNB1 TIRAP SEC23A B3GALT6 B4GALT7 WIPF1 WIPF2 WIPF3 FCGR1A SEC24B SEC24A IQGAP1 MAP3K11 SEC24D SEC24C DUSP16 FGFR1 TMPRSS2 WASL SRPK2 GALNT1 AXL TCN2 CD320 RCC1 VPS28 TSG101 WAS VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A MYO9B MVB12B MVB12A RANBP1 UBAP1 TPST2 TPST1 NRP1 MAP2K1 MAP2K2 ITGB3 ITGA2B MASP1 XRCC6 XRCC4 XRCC5 LIG4 CHST14 RPL4 RPL5 RPL30 TPMT RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A ACAN RPL36AL LUM RPL36 RPLP2 RPL35 RPL38 RPL37 AGRN RPL39 RPL21 FMOD CHD3 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 HDAC4 RPL27 HDAC2 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A SUZ12 RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 AMER1 RPL35A RPL23A GSK3B CSNK1A1 RPL3L AXIN1 RPL27A RPL22L1 APC RPL26L1 OPN1SW ENO1 CDC73 SKIC8 CTR9 RTF1 ALDOB LEO1 PAF1 HHAT SHH PGK1 DHH MAP2K4 CGAS CREBBP IRAK4 SP1 KHK TLR10 TLR5 AREG NFE2L2 BCL2L1 PTPN6 MAPK9 IRAK2 MAP2K7 CAMK4 NTF4 NTRK2 BDNF TAB3 TGFA TAB2 NFKBIB FOXO3 ELK1 PTK2 IFNA5 EREG IFNA4 BTC IFNA7 MC2R EPGN IFNA6 AKT3 CLEC4M JUN IFNA2 MED19 FZD7 IFNA8 WNT5A MED18 MED11 KCNJ11 ARIH1 ABCC8 IFNA13 ABCC9 IFNA14 ADCY9 IFNA16 IFNA17 ADCY4 BAG2 ADCY3 MED9 MED29 ADCY2 MED28 ADCY1 MED22 ADCY8 ADCY7 OAS2 MED21 ADCY6 MAP1B ADCY5 IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 ISG15 MED13L PRKG2 CD209 FGR GGT5 GSS OPLAH GCLC ITPR1 ITPR2 GGT1 ITPR3 GCLM NOS2 P2RX7 EML4 P2RX4 GNAS VPS33B CORO1A HGS RAB5A KPNB1 SLC6A20 SLC1A1 SLC3A1 SLC1A3 SLC3A2 UPK1A EPCAM FDXR SLC6A19 SLC36A2 SLC6A14 FDX1 FDX2 SLC7A7 SLC7A9 DUSP6 DUSP7 RPN2 ZDHHC20 TUSC3 PRKCSH RPN1 ZDHHC5 MAGT1 ZDHHC8 ZDHHC2 ZDHHC3 FUT8 GANAB MAN2A1 MGAT5 MGAT1 MGAT2 GOLGA7 OST4 EDEM2 MOGS ZDHHC11 DDOST MGAT4C ZDHHC9 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B CYP21A2 STT3A STT3B MAN1B1 ECHS1 RETREG1 KEAP1 H2AC17 AGK H2AC12 TRIM25 CFTR STAM CYP4F22 CYP19A1 H2AC25 H2AC21 WDR48 IFIH1 TRIM4 UFD1 IKBKG TOMM70 RIPK2 TBXAS1 KAT2B PIK3CD KAT2A RNF135 TAF9B SFTPC MAP3K7 GBE1 GYS2 H2AC1 CDC25A GYG2 EPM2A STAM2 PPP1R3C VCP NHLRC1 CLINT1 TNKS FOXO4 GALT CYP27A1 NLRP3 RIPK1 SUDS3 SMAD2 SMAD4 SMAD3 ESR1 NFKBIA SCAP MAVS MDM2 TAB1 RIGI PTEN ARRB1 ARRB2 TRAF2 MERTK H2BC18 TRAF3 TRAF6 BECN1 CYP7B1 NOD1 NOD2 TNKS2 TAF10 EIF4A3 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 AQR CRNKL1 DPEP2 CDC40 DPEP1 DHX9 CSTF3 CYP11A1 CSTF2 PCBP1 PCBP2 CSTF1 CYP11B2 DHX38 SYMPK RBM10 HNRNPL HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 PRPF19 PQBP1 PCF11 DHX15 DHX16 WDR33 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SF3B1 CTNND1 SRSF11 SF3A3 SF3A1 SF3A2 PPP1CA XAB2 NUDT21 PHF5A HNRNPA2B1 CWC25 CWC27 SV2C EFTUD2 SV2B PPP1CB SV2A VAMP1 CWC22 PAPOLA TXNL4A SNRPN MYO5A ZCRB1 WBP11 IRF4 PRPF6 BCL2A1 SNRPG SRSF2 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRPF SRSF5 SNRNP200 SRSF6 SRSF7 SNRPB SRSF9 DDX5 PRPF8 CPSF4 CPSF1 FUS ALYREF CPSF3 CCR5 CPSF2 CXCR4 CWC15 CHERP ISY1 DDX46 DDX42 YBX1 PTBP1 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 PLRG1 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP SNRNP40 CYSLTR2 PPIL3 PPIL4 SLC35D1 SLC35A2 SLC35A3 SLC33A1 SLC29A3 SLC27A4 KIT RBPJ B4GALT1 TXNIP SFN EZH2 CLDN1 MED16 MED15 MED17 MED12 MED14 MED13 HEY1 MED10 HEY2 MED27 MED26 MED23 MED25 MED24 MED20 RNASEK ATL2 LY6E NACA HNRNPA0 TIMD4 CD2BP2 HNRNPUL1 TYRO3 BTF3 AUP1 PPIL6 MAPRE3 EMC4 ELAVL2 PMS2 RICTOR MBD3 STAT1 GATAD2B GATAD2A CCNT2 CDC25C MSH2 KMT2D FOXO6 FOXO1 MED30 MED31 G6PC1 NFKB1 SFTPB SFTA3 SFTPA1 FASLG ITGA4 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A CCNK MUC5AC MUC3B CCNC ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 SH3GL3 EPS15 SH3GL2 SH3GL1 YES1 EEF2 CTSL SYVN1 RELA FZD8 ARPC1B ARPC1A NPM1 ITCH KLC1 ARPC4 ARPC5 MAMLD1 ARPC2 ARPC3 IHH ACTR3 ACTR2 NR3C1 TRAK1 KIF5B IRAK1 NCKIPSD ACY1 IL6 TAF4B YWHAE PRR5 DPY30 CHD4 PPM1K YWHAQ AUH IVD YWHAG HIBCH C4A YWHAH TBP EED GALM TAF9 TAF1L MTA2 TAF15 TAF12 TAF13 TAF11 SOD2 REST TAF8 TAF7 KRAS TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 MAML2 MAML1 DNAJC3 JUNB MED1 GALK1 MED8 GALE MED4 MED6 MED7 MAML3 MAPKAP1 NEDD4L PRDX2 PRDX1 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 PLK2 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 C4B_2 CD19 V2-8 V1-20 ASH2L V1-9 TAF7L V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 C1QA C1S V4-6 V4-2 V4-1 ISCU SNAP25 SYT1 MSH3 PTPN12 NRBP1 TLR8 PAH KPNA7 KPNA4 KPNA5 GBP1 KPNA3 ABL1 GNS CDK8 CDK5 WDR5 PYCARD CLEC5A GYG1 HDAC5 RAB5B RAB5C HDAC8 HDAC9 HDAC6 HDAC7 RBBP4 RBBP5 RBBP7 TXNRD1 PML PGM1 HDAC10 TTR HDAC11 FCGR2A TWIST1 TXN PARP1 BST2 PRMT1 GP1BA HBB CD33 MLH1 TJP1 GAA CDK5R1 ESR2 NR4A1 CASP1 CD300A THBS1 ERBB2 HES1 DDX3X POMC PHB1 ARAF PEBP1 CSK JAK2 MARK3 HGSNAT FGB DYNLT1 BRAP FGA VWF KSR1 MMP9 FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 GALNS SLC9A6 SLC9A9 HCK SYK LCK UGT1A4 FYN F9 F10 GGCX PROS1 F2 GAS6 UGT1A1 BCKDK BCKDHA BCKDHB DBT DLD CLTC HDLBP CLTA AP2A1 AP2A2 AP2M1 CUBN AMN APOA1 SAR1B AP2S1 AP2B1 P4HB PRF1 ICOS STAT5A IL10RA ZC3HC1 CD3G BTRC ADAMTS13 MTA1 MTA3 FCGR3A MYH2 MYO10 MYO1C APRT PNP HPRT1 ADA PRKAR1B PRKAR2B PRKAR1A PRKAR2A PRKX FZD5 FZD4 FZD6 PIM1 GBP2 GBP4 IKBKE IRF7 GP1BB F12 F11 GP5 GP9 KLKB1 BAG4 RAN SLC20A2 NEK2 WNT3A LRP5 KREMEN1 TUBB KREMEN2 DKK1 DKK2 LRP6 DKK4 AKAP9 ABCA4 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 SUGT1 IGF1R CALM3 CALM2 CEP43 KDM7A ATP1B3 ATP1B2 ATP1B1 RBP4 RDH12 OPN1LW RBP1 NAPEPLD LRAT STRA6 FXYD4 MMAB FXYD3 HYOU1 FXYD2 GBP6 FXYD1 HBA2 STX1B FXYD7 CBLL1 FXYD6 GUCY2C SYT2 NHERF4 MTRR ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ANO10 CLCN6 SUN2 CBLIF MMACHC MMADHC NRG3 NRG4 NRG2 NTHL1 NEIL3 NEIL1 PIK3AP1 SIKE1 CSF2RB CSF2RA CD36 STAT5B GRB2 ARID4B CTBP2 CTBP1 SAP30 DNMT1 NCL CEBPD PDGFRB DNMT3B DNMT3A SAP30L RTN3 PATJ VPS39 VPS18 LARP1 VPS11 VPS16 HAVCR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 RCAN3 MBL2 CNBP VPS41 NPIPB3 VPS45 NMI PARP10 SFTPD PARP6 GSK3A IL17RC PARP4 IL17RA NLRP12 PARP16 PARP9 IL17F IL17A PARP14 PARP8 GEMIN2 TUFM GEMIN4 CRK GEMIN5 GEMIN6 FMO3 GEMIN7 GEMIN8 PPIB DDX20 IPO7 DNAJB11 P4HA1 P4HA2 FADD P4HA3 CD14 GSDMD DNAJC10 NMT1 GSDME C1QBP MAT1A RIPK3 IL18 IL1A IL1B TLR4 BCAP31 AHCY FNTA TICAM1 CHMP4C CHMP4B CHMP4A LY96 MLKL MAOA CHMP2B CHMP2A TRADD HMGB1 CASP8 CASP4 PDCD6IP CHMP3 CHMP6 CHMP7 GZMB APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 PSEN1 PAPSS2 PAPSS1 SDC4 SDC2 SDC3 SGSH NAGLU GPC1 GPC3 GPC2 GPC5 RPIA GPC4 GPC6 EXT1 SDC1 SLC5A5 LYN PIK3CG PIK3R6 PIK3R5 BTK ARF1 NPLOC4 RPLP0 JAK1 IL10 MSN TALDO1 TYK2 PPIA ALK AHCYL1 LMNA KPNA2 MMAA MMUT MCCC2 BTD PC PCCA HLCS MCCC1 PCCB SPCS3 SPCS2 SPCS1 SEC11A SEC11C FOXM1 GNAZ CD163 RHBDF2 ADORA2B JAG2 ADAM17 RDH5 RLBP1 CYFIP2 GJA1 ZMYM2 FGFR3 GYS1 TPM4 TPM3 RNF43 KLB FLT3 IRS1 IRS2 EIF4E3 PIK3CB PPM1B FGF1 FGF2 FGF3 EIF4G3 FGF4 EIF4G2 FGF6 NCK1 FGF7 FGF9 AKT2 HRAS WASF3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3CA PIK3R3 SPTBN1 TLR9 PIK3C3 SOS1 RAC2 SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 NRAS FGF20 PPFIBP1 ATP6V1H MAPK1 FGF23 FGF22 ELMO2 MAPK3 PTPN11 FGF16 FGF19 FGF18 FGFR4 FGF10 UNC93B1 TLR3 ABCA3 CAMK2B CAMK2D SRC CAMK2A NRG1 MTR ZAP70 CALM1 DOCK2 CAMK2G ANAPC15 DOCK1 ANAPC16 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CCNB1 CDC23 TRAT1 UBE2S RPS6KB2 CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 BLM MRE11 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 RBBP8 NBN TOPBP1 ATRIP BARD1 CYP11B1 RFC5 RMI2 RFC3 RFC4 RMI1 RFC2 XRCC2 TOP3A RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 APP RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 ATM DNA2 HGF RAD9B RHNO1 ATR RAD9A CLIP1 SLC25A15 CPS1 ARG1 ASL NAGS KDELR1 SERPING1 ASS1 GCC2 NMRAL1 OTC PDGFB CLU HSPA5 CTSG COG1 TLR1 S100A9 S100A8 LTF TLR2 F8 CD9 S1PR1 GOLGA2 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST PRIM2 CUX1 CD4 PRIM1 POLA1 POLA2 ACACA TRIP11 PDGFRA GTF2A1 CHSY1 GTF2A2 GTF2B GTF2E1 GTF2E2 FASN TCF7L2 CDKN1A HDAC1 CDKN2A CDC25B CCND1 SIN3A CDK2 CTNNB1 MET CEBPB TNRC6C MOV10 ACOT2 STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 GRPEL1 YWHAB ELAVL1 PSMD8 HMOX1 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 AKT1 PSMD1 NUP214 IDH1 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 XRN1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ABCD1 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 MAPK14 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 PEX19 SRD5A3 C3 FURIN SLC67A1 CPSF7 ROCK1 ROCK2 CUL3 SRRM1 VIM HNRNPC RBMX AP1G1 ZBP1 AP1S2 AP1S1 AP1S3 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 HLA-A CD8B PACS1 IDUA ELMO1 NCAN CD28 HEXB OPN1MW HEXA BGN PALS1 DCN BCAN VCAN HYAL1 GLB1 IDS CSPG5 CSPG4 GUSB ARSB UVRAG MAP1LC3B TRIM27 HSP90AA1 EGF CBL EGFR CYP17A1 CDC37 PLCG1 CDKN1C RB1 CDKN1B CCND3 FZR1 FNTB CCND2 E2F1 E2F2 E2F3 SKP2 DAXX ATRX CDK6 NMT2 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX LIG1 MSH6 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 SFPQ IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 RUNX1 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 TAL1 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 SRPK1 HDAC3 KDM1A GNAT3 GPS2 TBL1X ABCA1 ABCG8 ABCG5 NCOR2 NCOR1 TBL1XR1 DPAGT1 ST6GALNAC2 MPI HK1 GNAI3 GNAI1 GNAI2 ALG8 ST6GAL1 ALG9 ALG6 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 DHDDS DPM1 DPM2 DPM3 RFT1 ST6GALNAC3 ST6GALNAC4 SLC24A1 GNE NEU1 ST3GAL4 SLC17A5 ST3GAL1 AVP ST3GAL2 ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 SLC4A1 PMM2 ABCA12 SLC4A4 BSG GFPT1 SLC12A6 DOLK SLC39A4 SLC34A3 SLC34A2 SLC34A1 SLC11A2 SLC5A7 SLCO2A1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.5 Interleukin-35 Signalling TYK2 CANX IL6ST STAT4 JAK2 IL27RA EBI3 STAT3 IL12A JAK1 IL12RB2 STAT1 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 95%879518 Transport of organic anions SLCO4A1 SLCO1A2 SLCO2B1 SLCO4C1 SLC16A2 SLCO1B1 SLCO1B3 SLCO1C1 AVP SLCO2A1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME DATABASE ID RELEASE 95%2454202 Fc epsilon receptor (FCERI) signaling JUN RELA RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 ITK IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 VAV3 PPP3CA PPP3CB PRKCQ PPP3R1 VAV1 UBE2N VAV2 NFATC1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 NFATC2 V1-11 V1-16 V1-13 MAPK8 IKBKB V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 UBA52 BTK PSMD12 PSMD11 PSMD14 NFATC3 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A UBE2V1 ADRM1 PSMC5 PAK1 PSMC6 PSMC3 AHCYL1 PSMC4 PSMC1 PSMC2 PAK2 RASGRP4 MAP3K7 CARD11 MALT1 NFKBIA TAB1 TEC TRAF6 PLCG1 PIK3CB HRAS PDPK1 GAB2 PIK3CA SOS1 PIK3R2 PIK3R1 NFKB1 NRAS MAPK1 CHUK FCER1G MAPK3 CALM1 UBE2D1 FCER1A LAT2 BCL10 MS4A2 TXK MAP2K4 FBXW11 MAPK9 SYK MAP2K7 SEM1 MAP3K1 FYN MAPK10 TAB3 SKP1 TAB2 FOS CUL1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 95%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity NEDD4L TGIF1 UBE2D1 TGIF2 TRIM33 PARP1 HDAC1 UBA52 MAPK1 SKIL MAPK3 UBB ATP1B4 SKI UBC SMAD2 NCOR2 RPS27A SMAD4 SMAD3 NCOR1 SMURF2 SMAD7 SNW1 RNF111 WWTR1 PPM1A UBE2D3 USP9X RUNX3 REGULATES P14-ARF%REACTOME%R-HSA-8951936.2 RUNX3 regulates p14-ARF RUNX1 CCND1 BRD2 RUNX3 EP300 KRAS HDAC4 CBFB TGFB1 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 95%9662834 CD163 mediating an anti-inflammatory response MYH9 CD163 RHBDF2 FURIN ADAM17 IL10 MAPK14 PLK2 IL6 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle TFRC KIF14 KIDINS220 VANGL1 MUC13 PIK3R2 ARHGAP5 TMEM59 PIK3R1 ARHGAP35 TXNL1 ALDH3A2 PKP4 RASAL2 STIP1 PLXNA1 ANKRD26 LEMD3 DEPDC1B CPD RBMX FAM83B FRS3 EPHA2 WDR6 DST UBXN11 DLG5 STMN2 EPSTI1 PTPN13 RND1 PLEKHG5 FRS2 FAM135A GRB7 VANGL2 FLOT2 DSP CAV1 RRAS2 CCDC88A INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 95%9670095 Inhibition of DNA recombination at telomere H2BC9 ACD H2AZ2 TINF2 POLR2A H4C9 TERF1 POLR2B H2BC8 TERF2 POLR2C H2BC5 POLR2D H2BC3 POLR2E H3-4 POLR2F H2BC1 POLR2G POT1 POLR2H TERF2IP POLR2I POLR2J H2AC20 POLR2K POLR2L DAXX ATRX H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9706019 RHOBTB3 ATPase cycle CUL3 PLIN3 RAB9A RAB9B HGS VHL CCNE1 RHOBTB3 LRRC41 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication POLRMT POLG2 RNASEH1 TOP3A POLG TWNK MGME1 EXOG SSBP1 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME%R-HSA-5657560.5 Hereditary fructose intolerance ALDOB COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation COL4A2 COL18A1 LOXL1 COL4A1 LOXL2 COL17A1 ITGB4 COL15A1 COL16A1 COL13A1 COL14A1 ITGA6 PLEC COL11A1 COL11A2 COL12A1 PLOD3 PLOD2 LOX COL19A1 PLOD1 COL10A1 COL28A1 COL26A1 COL27A1 COL24A1 COL25A1 COL22A1 COL23A1 PCOLCE COL2A1 COL5A1 COL6A2 COL5A3 COL4A4 CD151 COL7A1 COL6A1 COL4A3 COL5A2 COL8A2 CRTAP COL20A1 COL4A6 COL6A3 BMP1 COL21A1 COLGALT2 COL8A1 COL9A1 COL4A5 COL9A3 COL6A6 COL9A2 COL6A5 COLGALT1 CTSS PCOLCE2 P4HB TLL2 TLL1 ADAMTS2 ADAMTS3 PPIB LAMB3 P4HA1 LAMA3 P4HA2 P4HA3 LAMC2 COL1A1 COL1A2 ADAMTS14 MMP9 P3H2 P3H1 P3H3 PXDN MMP3 SERPINH1 CTSB CTSV MMP20 LOXL3 CTSL MMP7 MMP13 LOXL4 COL3A1 LANOSTEROL BIOSYNTHESIS%REACTOME%R-HSA-9969896.1 Lanosterol biosynthesis GGPS1 LSS SQLE IDI2 ACAT2 MVD IDI1 MVK PMVK FDFT1 FDPS PLPP6 HMGCS1 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 95%167172 Transcription of the HIV genome TAF7L CCNT2 TAF4B ELOB ELOC RNMT CCNH POLR2A TBP POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L RNGTT GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 SUPT5H GTF2F1 TAF11 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 TAF8 SUPT4H1 ERCC2 TAF7 ELOA MNAT1 NELFB TAF6 NELFCD TAF5 NELFA TAF4 NELFE TAF3 SUPT16H TAF2 NCBP1 TAF1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 TAF10 GTF2A1 GTF2A2 TAF9B GTF2B GTF2E1 GTF2E2 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2S1 AP2A1 AP2A2 AP2B1 AP2M1 CD8B ATP6V1H TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 95%6787450 tRNA modification in the mitochondrion TRIT1 YRDC TRMU TRMT61B OSGEPL1 GTPBP3 TRMT10C MTO1 PRORP HSD17B10 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%446728 Cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 VASP FBLIM1 PXN TGIF2 TESK1 EED LAMB3 ILK PARVA PARVB FLNA FLNC LAMA3 RSU1 LIMS2 LIMS1 LAMC2 POMT2 POMT1 PRKCI RACK1 COL17A1 PLEC RPN2 ARHGEF6 PRKCSH HDAC1 RPN1 ACTN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ITGB4 ARHGAP32 ITGA6 FURIN PCSK6 FERMT2 TLE1 SPCS3 SPCS2 CD151 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 DST PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP ITGB1 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME%R-HSA-9010553.2 Regulation of expression of SLITs and ROBOs RBM8A ISL1 ETF1 GSPT2 GSPT1 UPF3A USP33 UPF2 LDB1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 DAG1 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 EIF4A3 RPS24 RPS27 RPS23 MAGOH HOXA2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 ZSWIM8 RPL34 MSI1 RPL10L RPL8 RPL10A RPL6 RPL7 LHX3 RPL7A RPL18A RPL36AL LHX2 RPL36 LHX4 RPLP2 RPL35 LHX9 RPL38 RPL37 COL4A5 RPL39 UPF3B RPL21 MAGOHB RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 SLIT2 RPL27 ROBO1 RPL26 RNPS1 RPL29 RPL28 RPL10 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A ROBO2 RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PABPC1 UBA52 PSMD12 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CASC3 PSMB4 PSMB5 UBB PSMB2 PSMB3 NCBP1 SLIT1 UBC NCBP2 PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 95%2029482 Regulation of actin dynamics for phagocytic cup formation BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV NF2 ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 HSP90AA1 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 LIMK1 FCGR2A VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 HSP90AB1 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 BTK CFL1 ACTB MYO5A SYK PAK1 NCKAP1L WASF1 PTK2 WASF2 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%162585 Uncoating of the HIV Virion PPIA CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 95%1834949 Cytosolic sensors of pathogen-associated DNA RELA XRCC6 XRCC5 NFKB1 DHX9 CTNNB1 CHUK IKBKB RIPK1 MYD88 ZBP1 TLR3 TREX1 DDX41 DTX4 TBK1 IRF3 NFKBIA STING1 NLRP4 TRIM32 TRIM21 TRIM56 IRF7 NLRC3 IFI16 CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR2F POLR3D POLR3E POLR2H POLR3F UBA52 POLR3G PRKDC DHX36 POLR3H POLR2K POLR2L POLR3K MRE11 NFKB2 RIPK3 NKIRAS1 LRRFIP1 NKIRAS2 IKBKG UBB CGAS AIM2 CREBBP UBC TICAM1 RPS27A EP300 STAT6 NFKBIB POLR1C POLR1D NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-HSA-168643.3 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways RELA MAP3K7 NFKB1 HSP90AB1 ITCH PANX1 CHUK MAP2K6 NLRP3 IKBKB IRAK1 CARD9 TAB1 TXNIP HMOX1 TNFAIP3 MAPK12 MAPK13 CASP1 CASP2 P2RX7 PYCARD TRAF6 BIRC2 BIRC3 NLRC4 CYLD NFKB2 NOD1 NOD2 IKBKG NLRP1 RIPK2 AIM2 BCL2 UBE2V1 BCL2L1 AAMP MAPK14 IRAK2 MAPK11 APP MEFV PSTPIP1 TAB3 TAB2 SUGT1 CASP8 TXN CASP4 CASP9 UBE2N BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 95%9027604 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2 ALOX5 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 95%8856688 Golgi-to-ER retrograde transport KIF28P KDELR1 KDELR3 KIF5C KIF21A KIF21B KIFAP3 KLC1 KLC4 KLC3 KLC2 RINT1 KIF16B KDELR2 KIF3A KIF20B COPB2 PLA2G4A COPA TMED10 KIF3B SEC22B KIF3C RAB6B KIF5B KIF5A KIF18B KIF4B KIF4A COPE PAFAH1B2 KIF12 ARF4 KIF11 USE1 BICD1 BICD2 KIF15 KIF19 KIF13B TMED3 KIF1C KIF1B KIF1A TMED7 TMED9 KIF25 COPZ2 KIF22 KIF6 KIF27 COPZ1 KIF9 KIFC2 KIFC1 PAFAH1B3 ARF5 NAPA GBF1 NAPB NBAS RAB6A RAB1A STX18 RAB1B NAPG GALNT1 BNIP1 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB DYNC1LI2 GALNT2 ARCN1 ZW10 KIF26A KIF26B RAB3GAP2 COPG2 COPG1 KIF23 RAB3GAP1 RAB18 KIF20A KIF18A SURF4 PLA2G6 DYNLL1 DCTN6 DCTN5 DYNLL2 DCTN1 DCTN4 KIF2A NSF KIF2C KIF2B CAPZA3 PAFAH1B1 CAPZA2 DYNC1I2 ACTR10 ARF3 TMED2 DYNC1I1 DYNC1H1 CENPE AGPAT3 COPB1 ACTR1A ARF1 DCTN2 CAPZA1 DCTN3 RACGAP1 ARFGAP1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 95%3311021 SMAD4 MH2 Domain Mutants in Cancer SMAD2 SMAD4 SMAD3 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC CCT6A TUBA8 TUBA1C CCT2 TUBA1B TUBA1A CCT3 TUBB2B TUBB2A TCP1 CCT6B TUBAL3 TUBB6 TUBB3 CCT7 TUBA3E TUBB1 TUBA3D TUBA3C CCT8 CCT5 TUBA4B CCT4 TUBA4A TUBB4B TUBB4A TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 UBC TICAM1 RPS27A TLR3 TBK1 IRF3 TRAF3 OPTN UBA52 IKBKE IRF7 TANK UBB ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 95%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 NCBP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 95%174411 Polymerase switching on the C-strand of the telomere ACD PCNA TINF2 TERF1 TERF2 POT1 TERF2IP CHTF8 PRIM2 PRIM1 POLA1 DSCC1 POLA2 RFC5 POLD3 POLD4 RFC3 POLD1 RFC4 POLD2 CHTF18 RFC2 RFC1 STN1 TEN1 CTC1 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 95%9635465 Suppression of apoptosis MAPK1 CTSG TRIM27 SFPQ RNF213 GSK3A MAPK3 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 95%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes CREBBP BHLHE40 RBM4 DBP TFEB CRY2 CRY1 CIPC PER2 PER1 RORC PER3 RORA NR1D1 BMAL1 CRTC1 KMT2A SIK1 CLOCK NPAS2 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste TAS2R4 GNG13 KCNJ2 TAS2R10 GNB1 TAS2R13 TAS2R14 TAS2R16 GNB3 SCN9A TAS2R50 CALHM1 CALHM3 GNAT3 SCNN1G SCNN1D SCNN1B SCNN1A TAS2R40 TAS2R41 TAS2R43 TAS2R46 SCN4B TAS1R2 TAS1R1 TAS1R3 OTOP1 ITPR3 SCN1B TAS2R30 TAS2R7 TAS2R31 GRM1 TAS2R38 TAS2R8 TRPM5 TAS2R39 TAS2R20 TRPM4 PLCB2 SCN3A GRM4 TAS2R1 TAS2R3 SCN2A TAS2R5 SCN2B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DLL1 ADAM10 JAG2 ADAM17 JAG1 NOTCH1 DLL4 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%2022870 CS-GAG biosynthesis CHST15 CSPG4 CHST3 CHPF NCAN CHSY1 CHST11 BGN CHST12 CHSY3 DCN CHST13 CSGALNACT1 CHST7 BCAN CHPF2 VCAN CSGALNACT2 UST CSPG5 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.4 RAB GEFs exchange GTP for GDP on RABs MON1A TRAPPC6A MON1B DENND1C TRAPPC6B DENND1B GDI1 DENND1A ULK1 RAB8B DENND2D TRAPPC10 RAB14 DENND2C DENND2B DENND2A RAB3IL1 GDI2 RAB7B DENND3 RAB21 ALS2CL RAB27B CHML RAB12 RAB13 TRAPPC4 CHM RAB9A RAB6B RAB9B RAB39A YWHAE AKT1 ALS2 RAB3A RAB31 RAB5B RAB5C RAB3IP RAB6A RAB1A RAB1B TRAPPC1 RAB5A DENND5B RABGEF1 RINL TRAPPC12 TRAPPC11 DENND5A TRAPPC13 GAPVD1 RAB7A RIC1 RAB32 RAB35 RGP1 RAB27A RAB38 AKT2 DENND6B RIN3 RAB3GAP2 RAB8A TRAPPC2L DENND6A RAB10 RIN1 RIN2 RAB3GAP1 RAB18 TRAPPC2 TRAPPC3 ANKRD27 DENND4B TRAPPC5 CCZ1B TRAPPC9 DENND4A DENND4C SBF1 HPS1 CCZ1 SBF2 HPS4 RAB39B AKT3 TRAPPC8 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159231 Transport of Mature mRNA Derived from an Intronless Transcript NUP85 TPR NUP62 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 CPSF4 NUP210 NUP153 CPSF1 NUP93 NUP50 ALYREF NUP35 CPSF3 NUP54 CPSF2 NUP37 SYMPK NCBP1 NCBP2 EIF4E NUP205 POM121 WDR33 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 95%75158 TRAIL signaling TNFSF10 TNFRSF10B TNFRSF10A CASP10 CASP8 TNFRSF10D FADD CFLAR INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling TYK2 IL6ST JAK2 STAT3 CBL JAK1 SOCS3 IL6R STAT1 PTPN11 IL6 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME%R-HSA-6811440.2 Retrograde transport at the Trans-Golgi-Network SCOC SYS1 GCC2 GCC1 RAB43 GOLGA1 ARFIP2 RHOBTB3 COG8 COG7 COG6 NSF COG5 COG4 COG3 COG2 COG1 ARL1 VTI1A PLIN3 RAB9A RAB6B RAB9B RABEPK M6PR NAA30 IGF2R NAA35 NAA38 VAMP4 NAPA NAPB TGOLN2 TMF1 STX16 RAB6A NAPG STX10 ARFRP1 VPS51 GOLGA4 VPS53 VPS52 STX6 VPS54 VAMP3 RIC1 RGP1 USP6NL SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2 LEFTY2 LEFTY1 SMAD4 SMAD3 CRIPTO3 FURIN DAND5 PCSK6 CFC1 CER1 NODAL GDF1 CRIPTO MAPK1 FOXH1 ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C FOXO3 MAPK3 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions MT1G MT1H MT1X MT4 MT1B MT3 MTF1 MT1E CSRP1 SNCB MT2A MT1A MT1M MT1F DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.3 Interconversion of polyamines SAT1 PAOX PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 95%5651801 PCNA-Dependent Long Patch Base Excision Repair LIG1 RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 POLE FEN1 RFC2 RFC1 RPA1 RPA2 POLE4 RPA3 POLB POLE2 POLE3 APEX1 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%191273 Cholesterol biosynthesis ARV1 GGPS1 CYP51A1 LSS SREBF2 SQLE DHCR7 IDI2 ACAT2 MVD EBP LBR HSD17B7 DHCR24 PLPP6 NSDHL MSMO1 IDI1 MVK TM7SF2 PMVK SC5D FDFT1 SREBF1 FDPS HMGCS1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC6A20 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC3A2 SLC7A11 SLC7A10 SLC7A1 SLC1A5 SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC36A4 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling NRG1 ERBB2 GRB7 NRG2 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190239 FGFR3 ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 95%909733 Interferon alpha beta signaling IFNA2 ADAR IRF1 IRF2 IFNA8 XAF1 IFNA13 HLA-H IFNA14 IFNA16 IFNA17 HLA-B BST2 HLA-C HLA-F HLA-G HLA-E OAS2 IFITM3 IFITM2 IFNA10 IFIT5 IFI35 IFNA21 IFIT3 IFNB1 IFIT2 EIF2AK2 ISG15 RSAD2 IFI27 STAT1 SOCS1 PTPN1 IP6K2 PTPN11 EGR1 IFI6 IFITM1 ISG20 IRF8 IRF6 IRF3 IRF9 IFNAR1 SAMHD1 HLA-A GBP2 IRF7 PSMB8 ABCE1 KPNA1 UBA52 OASL OAS1 OAS3 RNASEL JAK1 KPNB1 USP18 UBB IFIT1 UBC TYK2 MX2 RPS27A MX1 STAT2 SOCS3 PTPN6 IRF4 IRF5 IFNA5 IFNA4 IFNA7 IFNA6 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells MPO LPO INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ACE2 FURIN ANO1 TMPRSS2 ANO10 ANO8 ANO9 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVP AVPR2 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 95%9665249 Resistance of ERBB2 KD mutants to afatinib ERBIN HSP90AA1 ERBB2 CDC37 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade PRKCA PDE6G GNB1 GUCY2D GUCA1B GUCA1A GUCA1C GUCY2F GNGT1 NMT1 GRK1 GRK7 FNTB RHO CNGA1 GNAT1 RCVRN CAMKMT SLC24A1 RGS9BP SAG NMT2 PPEF1 METAP1 METAP2 CNGB1 FNTA PRKCQ PDE6B CALM1 PDE6A BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.3 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB DEGRADATION OF DVL%REACTOME%R-HSA-4641258.3 Degradation of DVL PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL3 PSMA7 PSMB6 PSMB7 HECW1 KLHL12 PSMB4 PSMB5 DACT1 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 DVL1 PSMC4 PSMD8 DVL2 PSMC1 PSMD6 DVL3 PSMC2 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.6 Melanin biosynthesis TYRP1 SLC45A2 TYR OCA2 DCT SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702624 sorafenib-resistant FLT3 mutants FLT3 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE TIAM1 ARHGEF9 SOS1 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 SOS2 NGF ARHGEF5 NGEF ARHGEF6 ARHGEF26 MAGED1 KALRN APH1A FGD1 PSENEN FGD2 GNA13 NCSTN FGD3 APH1B PSEN2 ABR FGD4 PSEN1 MAPK8 BCL2L11 ITGB3BP ECT2 ARHGEF33 NGFR ARHGEF35 ARHGEF37 BAD ARHGEF39 MCF2 ARHGEF38 NET1 SQSTM1 YWHAE CASP2 TRAF6 UBA52 BEX3 UBB UBC RPS27A TRIO RASGRF2 ITSN1 ARHGEF10L AATF AKAP13 PREX1 MCF2L RAC1 ARHGEF40 VAV3 ARHGEF11 ARHGEF10 ARHGEF12 PLEKHG2 ARHGEF15 PLEKHG5 ARHGEF17 ARHGEF16 ARHGEF19 ARHGEF18 VAV1 VAV2 CASP3 TIAM2 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G2D PLA2G2E PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 PLAAT3 PLA2G2A LPCAT1 PLA2G4A PNPLA8 PLA2G4F PLA2G12A TMEM86B PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 PLB1 LPCAT3 PLBD1 LPCAT2 PLA2G2F MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation YAP1 GLI3 HEY1 HES1 BGLAP HEY2 ABL1 RB1 WWTR1 SRC YES1 MAF HDAC3 COL1A1 SATB2 MAPK1 HDAC6 SP7 UCMA MAPK3 CBFB ZNF521 AR CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.4 Conjugation of carboxylic acids GLYATL3 ACSM1 GLYATL2 ACSM2B GLYATL1 ACSM2A ACSM5 GLYAT ACSM4 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins EPB41L3 HOMER3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN APBA3 APBA2 EPB41L1 STX1A SHARPIN SYT9 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 CASK NRXN2 GRIN2A LIN7A DLG2 LIN7C DLG3 LIN7B DLG4 PDLIM5 NLGN4Y NLGN4X SYT10 SYT12 APBA1 SYT1 DBNL GRM1 GRM5 PI-3K CASCADE:FGFR3%REACTOME%R-HSA-5654710.4 PI-3K cascade:FGFR3 FGF18 FGF1 FGF2 FGF4 PIK3R1 FGF9 FGF20 FGF23 GAB1 FRS2 PIK3CA PTPN11 FGF16 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 95%5626467 RHO GTPases activate IQGAPs CDC42 RAC1 IQGAP1 IQGAP2 IQGAP3 CTNNB1 CDH1 MEN1 CALM1 CLIP1 CTNNA1 EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.3 EPH-Ephrin signaling CLTC CLTB TIAM1 CLTA AP2A1 AP2A2 ARHGEF7 ARPC1B NGEF ARPC1A AP2M1 RHOA KALRN APH1A PSENEN ROCK1 NCSTN ROCK2 APH1B PSEN2 CLTCL1 ARPC4 ADAM10 ARPC5 PSEN1 ARPC2 ARPC3 DNM1 ACTR3 ACTR2 ARHGEF28 SDC2 CDC42 AP2S1 AP2B1 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 GRIN2B EPHA1 EPHA3 GRIN1 MYL9 EPHA10 EPHB6 EFNB2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 EFNA5 EFNA4 CFL1 GIT1 EFNA1 EFNA3 WASL EFNA2 ACTG1 MMP9 ACTB MMP2 NCK2 EPHA2 ITSN1 RASA1 SDCBP YES1 PAK1 PAK3 LIMK2 RAC1 HRAS LIMK1 MYL12B FYN VAV3 MYL6 MYH9 MYL12A MYH14 MYH11 MYH10 PAK2 PTK2 VAV2 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 95%418457 cGMP effects PDE10A KCNMA1 PDE9A PDE1B PDE1A ITPR1 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE2A PRKG2 IRAG1 PDE5A MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 95%9939291 Matriglycan biosynthesis on DAG1 SLC35A1 CHST10 DAG1 RXYLT1 LARGE1 LARGE2 FKTN SLC35A4 FKRP CRPPA POMGNT1 B4GAT1 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9700645 ALK mutants bind TKIs ALK HIP1 PRKAR1A CLTC STRN PPM1B BIRC6 NPM1 EML4 FN1 EIF2AK3 BCL11A SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 95%9006115 Signaling by NTRK2 (TRKB) TIAM1 SOS1 FRS3 CDK5 NTF3 PIK3R1 NRAS PLCG1 SRC DOCK3 RAC1 HRAS GRIN2B NTF4 NTRK2 BDNF GAB1 FRS2 PIK3CA CDK5R1 PTPN11 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME%R-HSA-9956508.1 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CB JAK2 PIK3CD LYN GAB1 PIK3R1 PIK3CG PIK3CA PIK3R5 EPO EPOR IRS2 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS HRAS RAPGEF1 SOS1 JAK2 SHC1 LYN NRAS CRKL EPO VAV1 EPOR IRS2 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 95%3229121 Glycogen storage diseases UBC GYG1 RPS27A SLC37A4 G6PC1 GBE1 UBA52 GYS1 GYS2 GYG2 EPM2A PPP1R3C NHLRC1 GAA G6PC3 UBB GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 95%70326 Glucose metabolism GCKR GCK PPP2R5D G6PC1 PC PRKACG PRKACA PRKACB PCK1 PPP2CA PPP2CB SLC37A4 HK1 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 GPI TPR ADPGK NUP62 ENO1 ENO2 NUP88 ENO3 NUP43 HK2 RAE1 ENO4 HK3 NDC1 TPI1 RANBP2 SEC13 PGAM1 PGAM2 NUP155 NUP133 BPGM NUP210 PGM2L1 HKDC1 ALDOC NUP153 NUP93 ALDOB NUP50 ALDOA GAPDH NUP35 NUP54 PFKFB2 PFKFB1 PFKFB4 PFKFB3 PCK2 PGK1 SLC37A1 NUP37 PGK2 G6PC2 PFKL G6PC3 FBP1 GNPDA1 FBP2 GNPDA2 PFKM PFKP PPP2R1B PPP2R1A GAPDHS REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 95%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP CITED2 ARNT CA9 HIGD1A VEGFA EPAS1 EP300 HIF1A EPO ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation MRAS PPP2R5B PPP2R5A PPP2R5D PPP2R5C NRAS PHB1 MAP3K11 ARAF SHOC2 RAF1 JAK2 MARK3 BRAP KSR1 PPP1CB PPP1CC BRAF PPP2R1B PPP2R1A PPP2CA PPP2CB CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS MAP2K1 MAP2K2 CALM1 CAMK2G PPP2R5E ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 95%2142753 Arachidonate metabolism CYP4B1 FAAH DPEP2 DPEP1 ALOX15 LTA4H PTGES3 PTGDS CYP4F3 CYP4F8 CYP2J2 PRXL2B PLA2G4A GGT5 PTGES PTGR1 CYP4A22 PTGR2 GGT1 ABCC1 PTGIS PTGS2 PTGS1 ALOX5 ALOX15B LTC4S PON3 HPGD PON2 PON1 EPHX2 GPX2 HPGDS ALOX5AP MAPKAPK2 CBR1 CYP4F22 CYP2C9 CYP2C8 CYP2U1 ALOX12B CYP4F2 CYP1A2 CYP4A11 CYP1A1 CYP1B1 CYP2C19 CYP4F11 SLC27A1 TBXAS1 PTGES2 ALOX12 GPX1 GPX4 CYP8B1 FAAH2 AKR1C3 AWAT1 ALOXE3 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 95%111469 SMAC, XIAP-regulated apoptotic response XIAP CYCS CASP9 CASP7 APAF1 DIABLO CASP3 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559580 Oxidative Stress Induced Senescence JUN H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 CDKN2A H2AC20 MAPK1 MAPK8 IFNB1 MAP3K5 MAP2K6 MINK1 MAPK3 TNRC6C TNIK MOV10 BMI1 AGO3 CBX6 AGO4 RING1 MAP4K4 AGO1 MDM2 TNRC6A MDM4 TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 EED CDKN2D CDKN2C MAPKAPK2 UBA52 CDKN2B E2F1 RBBP4 E2F2 MAPKAPK5 E2F3 EZH2 CDK6 TFDP1 RBBP7 TFDP2 CDK4 H2AX MAP2K3 UBB MAP2K4 H2AB1 MAPKAPK3 UBC H2AC19 H2BC26 H2AC14 RPS27A H2BC12L H2BC21 H3-3B H3C8 MAPK9 MAPK14 H2AC8 MAPK11 H2AC6 H2AC7 H2BC17 MAP2K7 H2BC12 H2BC13 MAPK10 H2BC14 H2AJ H2BC15 FOS TP53 H2BC11 TXN KDM6B H3C15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.6 Scavenging by Class B Receptors APOA1 SSC5D S100A9 PRDX1 CD5L APOB CD36 SAA1 HMGB1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 95%8955332 Carboxyterminal post-translational modifications of tubulin TPGS1 TPGS2 TUBB8 AGBL5 AGBL4 AGBL1 AGBL3 TUBA1C AGBL2 TUBA1B TUBB8B TUBA1A LRRC49 VASH2 VASH1 TUBB2B TUBB2A TTLL7 TTLL6 TTLL5 TTL TTLL4 TUBB6 TTLL3 TUBB3 TTLL2 TUBA3E TUBB1 TTLL1 SVBP TTLL9 TTLL8 TUBA3D AGTPBP1 TUBA3C TTLL10 NICN1 TTLL13 TTLL11 TTLL12 TUBB4B TUBB4A DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions CLEC5A SOS1 SIGLEC14 PIK3R2 PIK3R1 HLA-B KLRK1 HLA-C KIR3DS1 NRAS PLCG1 BTK HLA-E GRAP2 NCR2 KIR2DS2 SIRPB1 KIR2DS4 KIR2DS5 CD300LB TREM1 SIGLEC16 SIGLEC15 CD300E LCP2 KLRC2 KLRD1 PIK3CB TREM2 B2M SYK RAC1 HRAS LCK FYN VAV3 PLCG2 PIK3CA VAV2 TYROBP DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.4 DNA Replication Pre-Initiation ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 PRIM2 PRIM1 POLA1 H2AX POLA2 H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L POLE H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 POLE4 H2AJ H2BC15 H2BC11 POLE2 POLE3 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDC7 CDK2 CDC45 KPNA6 MCM10 DBF4 RPA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 RPA1 RPA2 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN RPA3 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors STAB1 APOB SPARC STAB2 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%9630747 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCB6 ABCB4 SEL1L KCNJ11 ABCC8 ABCC9 ERLIN1 ERLIN2 RNF185 APOA1 ABCD4 VCP ABCC2 ABCA1 ABCG8 ABCC6 ABCG5 LMBRD1 DERL3 DERL1 DERL2 ABCB11 RNF5 ERLEC1 OS9 ABCA3 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 CFTR PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ABCD1 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ABCA12 MYOCLONIC EPILEPSY OF LAFORA%REACTOME DATABASE ID RELEASE 95%3785653 Myoclonic epilepsy of Lafora EPM2A UBC GYG1 RPS27A PPP1R3C NHLRC1 UBA52 GYS1 UBB THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8849175 Threonine catabolism SDS SDSL RIDA P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint PLK3 CDC25A PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CHEK1 PSMB5 CSNK1E NEK11 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 95%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 95%1236977 Endosomal Vacuolar pathway HLA-H CTSV B2M HLA-B CTSL HLA-C CTSS HLA-A HLA-F HLA-G HLA-E LNPEP GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI3 GLI2 GLI1 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME DATABASE ID RELEASE 95%4085377 SUMOylation of SUMOylation proteins NUP85 TPR NUP62 PIAS4 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 TOPORS SUMO2 UBE2I SUMO1 NUP205 POM121 NUP107 NUP188 AAAS NUP160 NUP214 POM121C NUP42 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654727 Negative regulation of FGFR2 signaling CBL UBA52 FGF20 MAPK1 FGF23 FGF22 MAPK3 BRAF UBB PTPN11 PPP2R1A FGF16 PPP2CA FGF18 PPP2CB UBC FGF1 FGF10 FGF2 FGF3 RPS27A FGF4 FGF6 FGF7 FGF9 MKNK1 SPRY2 FRS2 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 95%2559583 Cellular Senescence RPS6KA1 JUN CXCL8 RELA HMGA2 H1-1 H1-0 H1-3 LMNB1 IFNB1 CABIN1 H1-2 MAP2K6 H1-5 H1-4 HIRA UBN1 EP400 ASF1A MDM2 MDM4 IL6 EED CDKN2D CDKN2C RB1 HMGA1 CDKN1B FZR1 E2F1 IGFBP7 RBBP4 E2F2 MAPKAPK5 E2F3 CDK6 IL1A TFDP1 RBBP7 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TXN KDM6B H3C15 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 VENTX TERF2 H2BC8 H2BC5 H2BC3 MAPK7 STAT3 H3-4 H2BC1 NFKB1 CDKN1A POT1 TERF2IP H2AC20 CDKN2A MAPK1 CDK2 MAPK8 MAP3K5 CEBPB MINK1 MAPK3 ETS1 ETS2 EHMT2 EHMT1 ERF TNRC6C TNIK MOV10 ID1 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 MAP4K4 TNRC6A TNRC6B RNF2 SUZ12 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 MAPKAPK2 UBE2S CDC26 UBA52 CDKN2B CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 EZH2 KAT5 NBN MAP2K3 UBB MAP2K4 MAPKAPK3 UBC SP1 RPS27A MAPK9 MAPK14 MAPK11 MAP2K7 RAD50 MAPK10 TP53 FOS CCNA2 ATM CCNA1 RPS6KA3 RPS6KA2 GSD II%REACTOME%R-HSA-5357609.5 GSD II GYG1 GAA SIGNALING BY FGFR4 IN DISEASE%REACTOME DATABASE ID RELEASE 95%5655291 Signaling by FGFR4 in disease HRAS SOS1 FGFR4 GAB1 FRS2 PIK3R1 NRAS PIK3CA PLCG1 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 PRDX1 RELA MAFG PGD NFKB1 ABCG2 NQO1 CDKN2A GSTA3 GSTA1 SRXN1 CHD6 CCL2 ABCF2 PRKAA2 SOD3 G6PD SQSTM1 ATF4 GCLC TKT ABCC3 MYC ABCC1 GCLM PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B IDH1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 EGF PSMA2 UBA52 PSMD12 PSMD11 ME1 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 BACH1 UBB TXNRD1 PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 PSMB1 BCL2 PDGFA RPS27A MAFK SLC7A11 AREG NFE2L2 BCL2L1 EP300 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 TXN NOTCH1 CUL1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%1660499 Synthesis of PIPs at the plasma membrane MTMR3 MTMR8 MTMR9 RAB14 PIK3R2 MTMR6 PIK3R1 PIP5K1A PIP5K1B MTMR14 PI4K2B MTMR2 PIK3C2A MTM1 INPP4A INPP4B INPP5J INPP5K PI4K2A PTEN MTMR1 PIP5K1C INPP5D PIK3CG PIK3R6 PIK3R5 ARF1 RAB4A RAB5A OCRL SYNJ2 PIK3CB SYNJ1 PLEKHA1 PIK3CD PLEKHA2 PIK3C2G PIP4K2A PIK3C2B PIP4K2B PLEKHA5 PIP4K2C PLEKHA6 PLEKHA3 PLEKHA4 BMX PLEKHA8 PTPN13 INPPL1 RUFY1 PIK3CA PIK3R3 SBF2 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME%R-HSA-189085.4 Digestion of dietary carbohydrate CHIA AMY2A AMY1A MGAM AMY2B TREH AMY1B SI AMY1C LCT CHIT1 FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 95%140877 Formation of Fibrin Clot (Clotting Cascade) GP5 SERPINA5 GP9 SERPING1 KLKB1 CD177 THBD GP1BA KNG1 C1QBP FGB F3 FGA VWF FGG PF4 F2R A2M PRCP TFPI F13B PRTN3 SERPINC1 F7 F13A1 F9 PROC F10 SERPIND1 F5 PROS1 PF4V1 F8 F2 SERPINE2 GP1BB F12 F11 PROCR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.6 RNA Polymerase II Transcription Termination SRSF6 CLP1 SRSF7 MAGOH ZNF473 SNRPD3 SNRPB SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF7 CPSF1 ALYREF DDX39B CPSF3 CSTF3 CSTF2 CPSF2 SRRM1 CSTF1 DHX38 SYMPK UPF3B MAGOHB RNPS1 PCF11 WDR33 LUZP4 POLDIP3 SRSF1 SLU7 CSTF2T U2AF1 FYTTD1 U2AF1L4 FIP1L1 PABPN1 U2AF2 SRSF11 NUDT21 CASC3 PAPOLA LSM10 NCBP1 LSM11 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SNRPG SRSF2 SRSF3 SNRPE EIF4A3 SRSF4 SNRPF SRSF5 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME%R-HSA-428542.5 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 SLIT1 SLIT3 DCC NTN1 NELL2 SLIT2 ROBO1 SRC DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 95%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling AIP ARNT2 PTGES3 ARNT AHRR HSP90AB1 AHR STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels BEST2 SLC9C1 BEST3 SLC9C2 BEST1 BEST4 SLC9B1 SLC9B2 RAF1 SCNN1G SCNN1D SCNN1B SCNN1A TTYH3 TTYH2 CLCNKB WNK4 CLCNKA NALCN ASIC4 ASIC5 CLCA2 CLCA1 ASIC2 ASIC3 CLCA4 ASIC1 TRPM1 SRI TRPM2 TRPM7 TRPM8 TRPM5 WNK1 TRPM6 TRPM3 WNK2 TRPM4 WNK3 TRPC7 TRPC5 MCOLN3 TRPC6 RYR1 TRPA1 RYR2 TRPC3 RYR3 TRPC4 UNC80 TRPC1 TRPV2 TRPV3 CLIC2 TRPV1 TSC22D3 ANO8 MCOLN1 ANO9 MCOLN2 TRPC4AP ANO6 TRPV6 ANO7 TRPV4 ANO4 TRPV5 ANO5 ANO2 ANO3 TRDN ANO1 ASPH SGK3 SGK2 STOML3 CLCN3 CLCN2 CLCN1 BSND ANO10 SLC17A3 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 STOM NEDD4L SGK1 CALM1 UBA52 WWP1 UBB UBC RPS27A OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 95%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.4 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%168256 Immune System SEL1L ERLIN1 ERLIN2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 UBE2V2 RAC1 VAV3 COPS5 UBE2N VAV1 VAV2 ADAR SOS2 DCTN6 DCTN5 DCTN1 DCTN4 HSPA1L HSPA2 CAPZA3 MAPK8 BCL2L11 CAPZA2 ACTR10 HSPA1B SOCS1 IFNGR1 IFNGR2 IKBKB SQSTM1 MYD88 UBE2I SUMO1 UBE2D2 UBE2D3 ELOB ELOC RBX1 EPAS1 CUL2 HIF1A VHL POLR2E POLR2F POLR2H POLR2K POLR2L KRT1 ACTB FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B TP53 FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 SPHK1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 TCP1 BTNL2 XDH MT2A CCT8 TUBB4B NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 DSC1 NUP50 NUP35 NUP54 NUP37 ACTG1 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 DSN1 DIAPH1 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 RHOA KIF2A BIRC5 EVL KIF2C KIF2B CHUK DYNC1I2 IP6K2 CDC42 PPP2CA PPP2CB DYNC1I1 DYNC1H1 CENPE EIF2AK3 CENPS CRCP MCL1 POLR3GL POLR3A POLR3B VEGFA POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K IL22 NFKB2 CD274 IL2RG LRRFIP1 FCN2 BIN2 FCN3 CRP COLEC10 SKP1 CUL1 SLC15A4 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 CA1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IL1R1 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 PRKRA IGKV4-1 TARBP2 IGHV7-81 IFNAR1 IGKV2D-30 IGHV4-59 TRPM2 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHM LAMA5 SH3KBP1 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV IGKV2-29 FN1 IGKV2-28 BRWD1 IGLC3 BLNK IGLC1 VTN IGLC2 JAK3 IGKV3D-20 IGHD TLR7 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 BRD4 IGLC7 IGHV3-53 IGKV5-2 STAT2 IGLC6 IGKV1-5 IMPDH1 IMPDH2 PDCD1 LIMK1 EEF1A1 MYH9 LRR1 CCNF UBE2L6 CBLB HERC5 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 IL23R FBXO9 IL13RA2 IL13RA1 HLA-H IL4R WSB1 FBXO2 IL23A HLA-B FSCN1 HLA-C NDN ATG14 LIF NANOG HLA-F IGHE HLA-G HSP90AB1 HLA-E OPRD1 OSM RNF126 CDC34 BATF HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 RNF217 PRKAA1 ATG7 PRKAA2 CAB39 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 CD207 CALR FBXL4 MLST8 DZIP3 RNF220 EIF4E DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 MTOR LRRC41 VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 LAMTOR2 UBE2G2 LAMTOR1 PSMB8 PSMB9 LAMTOR3 KLHL9 SPSB2 CYFIP1 NCKAP1 SPSB1 KBTBD6 NCF1 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 BRK1 UBE3C UBE2D4 UBE3D FBXO27 LTN1 RNF19B UBE3A UBE3B FBXO21 UBE2Z STBD1 FBXO22 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 RAPGEF1 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 RAB7A TRAIP RNF41 KLHL42 UBE2V1 CUL7 CUL5 UBA7 UBA6 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 ABL2 FBXO40 NCKAP1L BTBD1 LONRF1 WASF1 UBE2F PAK2 RAG2 UBE2H RAG1 KLHL25 WASF2 UBE2B IL32 ZBTB16 RASGRP4 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 BAIAP2 FBXO31 KLHL20 UBE2W UBOX5 ABI2 UBE2U RNF182 UBA3 ABI1 UBE2O TPP2 UBA1 BLMH UBE2K TGFB1 UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 LMNB1 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP IL1RL2 PJA1 IL36A TAPBP IL36B TRAF7 IL36G UBE2R2 IL36RN SEC22B IL1F10 THOP1 TRIM50 SEC23A MGRN1 ASB13 ASB14 ASB11 CLEC10A RNF6 CLEC4A ASB12 WIPF1 CLEC4E RNF7 WIPF2 CLEC6A ASB17 WIPF3 DHX58 RNF4 RNF125 TAX1BP1 ASB18 RNF216 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 TNFRSF6B HECTD1 EDA HECTD2 TNFRSF13B HECTD3 TNFRSF11B ASB10 EDA2R TNFSF13B FCGR1A TNFRSF17 SEC24B TNFRSF8 TRIM41 ARHGAP45 TNFSF11 SEC24A TNFRSF4 ERAP2 EDARADD RNF25 TNFSF18 FBXL19 IQGAP1 TNFSF14 PLD1 ERAP1 TNFSF15 FBXL15 IQGAP2 FBXL16 CD70 TNFRSF9 FBXL13 EDAR FBXL14 FBXL12 TNFSF6 TRIM39 TNFSF4 LTA ASB8 JUP CD27 ASB9 LNX1 TNFSF9 TNFRSF25 ASB6 ASB7 TNFSF8 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 ARHGAP9 SEC24C ASB1 WASL PTPRZ1 PAG1 WAS STOM PAK3 MYO9B COLEC12 MAP2K1 COLEC11 HSP90B1 ITGAV NCAM1 FTH1 MASP1 FTL ITGB5 XRCC6 XRCC5 PDCD1LG2 B3GNT3 SPOP ITGAX PIAS1 SUZ12 GSK3B GPI ABCE1 HK3 KLRK1 PGAM1 KIR3DS1 PRKDC DHX36 FCER1A LAT2 BCL10 NCR2 ALDOC MS4A2 KIR2DS2 ALDOA KIR2DS4 KIR2DS5 CD300LB TREM1 PLPP5 PLPP4 TXK ATF1 PFKL SIGLEC16 ECSIT SIGLEC15 NKIRAS1 CD300E LPO NKIRAS2 MAP3K8 NLRP1 MAP2K3 KLRC2 IKBIP KLRD1 MAP2K4 CGAS CREBBP IRAK4 AIM2 MAPKAPK3 BCL2 TLR10 TLR5 ALPK1 LRRC14 NLRX1 NFE2L2 BCL2L1 PELI3 BTLA PELI2 NLRC5 PTPN6 TNFRSF14 AGER MAPK9 IRAK2 TIFA S100A12 MAP2K7 MAP3K1 S100B MAPK10 SAA1 TAB3 TAB2 FOS NFKBIB FOXO3 ELK1 PTK2 IFNA5 IFNA4 IFNA7 IFNA6 AKT3 JUN IFNA2 IFNA8 ARIH1 IFNA13 IFNA14 IFNA16 IFNA17 OAS2 IFNA10 IFNA21 IFNB1 PTPN22 EIF2AK2 ISG15 CD209 NOS1 APEH FGR STIM1 ORAI2 PECAM1 ORAI1 ITPR1 ITPR2 ITPR3 APOB NOS2 NOS3 MME P2RX7 P2RX1 IST1 KPNB1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PLA2G6 MAPK7 RPN2 TUSC3 PRKCSH RPN1 MAGT1 LTA4H ATF6 GOLGA7 OST4 LGMN DDOST LPCAT1 TMEM258 DAD1 OSTC CANX STT3A STT3B PTGS2 ALOX5 KEAP1 TRIM25 RNF123 GATA3 TNFRSF12A TNFSF12 SIAH2 TNFRSF13C TNFRSF11A CD40LG CYLD LTBR LTB IFIH1 TRIM4 IKBKG TOMM70 RIPK2 OSBPL1A PIK3CD PRKN RNF135 OTUD5 MAP3K7 RAB14 CPNE1 CPNE3 VCP NLRP3 RIPK1 SMAD3 CXADR SMURF2 SMAD7 NFKBIA MAVS TAB1 RIGI PTEN TNFAIP3 CD74 SLC44A2 GLIPR1 JAML CD99 TRAF2 TRAF3 TRAF6 BIRC2 BIRC3 USP14 BECN1 NOD1 NOD2 USP18 ORMDL3 PTGES2 TNIP2 INPPL1 EIF4A3 ALOX15 PLD4 PLD3 DHX9 ALDH3B1 PCBP2 DEGS1 HNRNPF HNRNPA2B1 ILF3 MYO5A RAB27A THOC5 CEACAM1 ZEB1 IRF4 PPIE CCR5 FPR2 YBX1 SNRPA1 ANXA1 PTAFR MMP3 CNTFR CNTF IL20RA IL20RB IL22RA2 TSLP IL31RA IL22RA1 CTF1 ATF2 STX3 IL10RB CLCF1 CRLF1 CRLF2 CSF3 TXLNA IL6ST SIGIRR IL27RA IRAK3 EBI3 MEF2C IFNLR1 B4GALT1 IL20 IL25 IL26 IL24 IL27 IL11 IL19 IL16 IL17RE OSMR IL17RB TXNIP IL31 IL17C IL11RA IL7 IL7R IFNL2 IFNL1 IFNL3 SFN COL1A2 EZH2 KCNAB2 CASP10 FAAP100 FAAP24 FAAP20 FANCM CTLA4 FANCL FANCA FANCB FANCE FANCG FANCF RICTOR STAT1 RORC RORA PDE12 OASL OAS1 OAS3 RNASEL BLK KMT2C FOXO1 SOCS3 NDUFC2 FBXO32 NFKB1 PIN1 FASLG ITGAL TRIM63 ITGA4 TNFRSF18 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 IL2RA NCR3 CD200R1 HCST MUC12 LILRA6 MUC15 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 PTPN4 NCR3LG1 LAIR2 MICA MUCL1 MUC3A MICB MUC5AC NPDC1 MUC3B GLYCAM1 LILRB1 KIR3DL1 LGALS3 KIR3DL2 CFP LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 MUC1 CD8A MUC2 KLRF1 CD300C CLEC4G KLRB1 MUC7 KIR2DL1 MUC4 KIR2DL2 MUC6 KIR2DL3 MUC16 KIR2DL4 CD300LD MUC17 KLRC1 CD300LF MUC19 CD300LG CD160 CRTAM MUC5B MUC20 ULBP1 MUC21 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 WWTR1 YES1 EEF2 SMARCA4 MLEC CTSV CTSL CTSK GBP7 TRIM8 TRIM6 YAP1 TRIM5 TRIM2 TRIM3 CSH1 RELA XAF1 CIITA TRIM68 TRIM62 TRIM46 TRIM48 ARPC1B TRIM45 ARPC1A NPM1 TRIM35 TRIM38 TRIM31 TRIM34 ITCH KLC1 IFITM3 KLC4 IFITM2 KLC3 IFIT5 KLC2 ARPC4 IFI35 ARPC5 IFI30 ARPC2 IFIT3 ARPC3 IFIT2 TRIM29 NF2 ACTR3 TRIM26 ACTR2 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 PRLR GH2 ISG20 GHR RAB9B KIF5B IRF8 IRAK1 KIF5A IRF6 NCKIPSD IRF9 SAMHD1 HLA-DOA HLA-DOB LAG3 IL2 CTSO IL3 CTSF IL6 MGST1 CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG CSF1 C4A EED CAT RETN SOD2 FUCA2 KRAS MMP1 MMP2 DNAJC3 JUNB RNF111 PRKCB CST3 PRKCQ CRKL MAPKAP1 NEDD4L CD81 C4BPA C4BPB IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 NFATC2 V2-19 V1-11 CPB2 CFH V1-16 V1-13 C5AR2 CFI CDK13 C5AR1 C4B_2 C2 C5 C6 C7 C9 CD19 V2-8 V1-20 C8B C8A ASH2L C8G V1-9 V5-4 CR2 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 CD46 C1QB TEAD2 C1QA C1S C1R TEAD3 TEAD4 CPN2 CPN1 CD59 CD55 V4-6 V4-2 V4-1 CFHR2 CFHR1 CFHR4 CFHR3 CFHR5 C1QC ICOSLG SNAP25 RAB3A DNAJC5 IL1RN WWP1 IL18RAP IL1R2 IL4 TOLLIP PTPN20 PTPN23 IL18BP IL13 IL1RAPL1 MAP3K3 PTPN18 IL37 PTPN12 PTPN14 PTPN9 CSF2 PTPN7 PTPN5 IL18R1 PTPN2 CNPY3 TLR8 CTSB FKBP5 KPNA7 KPNA4 KPNA5 GBP1 CSF1R KPNA3 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 SCAMP1 ABL1 RNASE2 UNC13D FLG2 PADI2 FPR1 GNS PLAC8 CRACR2A CYB5R3 PRDX4 S100A11 FUCA1 MAP2K6 AZU1 PA2G4 PRDX6 HRNR TCN1 PIGR PYGB SIGLEC9 FANCC PYGL MMP25 TIMP2 OLR1 SERPINB3 BCL6 SERPINB1 NFAM1 TMT1A TMC6 SERPINB6 PLEKHO2 PAFAH1B2 SERPINB10 GRN SERPINB12 GSTP1 AGA AOC1 AGL ERP44 LRG1 SLCO4C1 YPEL5 SIGLEC5 GHDC TMEM179B WDR5 RAB3D HP EPX PYCARD RAB44 CR1 LAMP1 CLEC5A TOM1 GYG1 CD177 KCMF1 OLFM4 ILF2 CLEC4C CLEC4D RAB31 RAB37 ADAM8 ARL8A RNF34 RAB5B NLRC4 RAB5C BRI3 HVCN1 GPR84 RAB6A RBBP4 TXNDC5 TRAPPC1 RBBP5 RAB4B PTPRB PTPRC NIT2 RBBP7 ITGAM ITGB2 FCAR ALAD FCGR3B PGM2 ACP3 SNAP29 PML PGM1 RNASET2 TNFRSF1B PKM TMBIM1 CANT1 FGL2 PRCP TTR RAB24 SOX2 CPPED1 RAB10 NFASC TSPAN14 FCGR2A RAB18 MNDA FOLR3 VPS35L CALML5 ANPEP TBC1D10C C6orf120 TWIST1 TXN CHIT1 SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 VAT1 PTPRN2 SIGLEC14 STK11IP SURF4 PRG2 NBEAL2 PRG3 DERA BST2 BST1 VNN1 CYSTM1 CTSZ GDI2 HBB PTPRJ ACTR1B CTSH CD33 CTSC CD53 MANBA FCER1G GAA NME2 COMMD3 CEACAM3 RAP2C RAP2B CEACAM6 CEACAM8 LIFR CD47 CD44 KCTD6 DNASE1L1 CSTB LILRA3 PGRMC1 CXCR1 CREG1 CXCR2 CD58 LAIR1 SMURF1 GCA LILRB2 LILRB3 SVIP QPCT CD68 FCN1 SRP14 MPO PLAU COTL1 SIRPA SLC2A3 ENPP4 OSTF1 CASP1 CD93 CASP2 CD300A IRAG2 OPRM1 ATAD3B OSCAR TYROBP DOK3 COPB1 IFNG ADGRG3 DPP7 MGAM HSPA6 GGH DNAJC13 ADA2 IGF2R SELL TARM1 MAN2B1 MS4A3 DDX3X TNFAIP6 CRISP3 POMC CXCL1 SLC2A5 SIRPB1 HEBP2 ADGRE5 CSK JAK2 NAPRT ADGRE3 HGSNAT FGB DYNLT1 ATP6AP2 FGA PLAUR MMP8 MMP9 FGG CHI3L1 PDXK CLEC12A MVP CAND1 TMEM30A VCL CMTM6 PDAP1 GALNS S100P PTX3 HCK SYK LCK FYN PROS1 F2 CLTC CLTA CXCL8 AP2A1 CXCL2 AP2A2 AP2M1 CCL11 CCL3L3 CCL5 NPC2 CCL4 CCL3 CCL2 SAR1B CCL19 CCR1 AP2S1 CCL22 CCL20 CXCL10 AP2B1 P4HB POU2F1 LBP VASP STAT5A IL10RA ITK TRAC CD3G FLNA CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 FYB1 ENAH HLA-DPB1 TRAV8-4 HLA-DRA LCP2 HLA-DRB3 HLA-DRB1 HLA-DQB2 LAT CD101 HLA-DQB1 FCGR3A MYH2 MYO10 MYO1C AMPD3 APRT PNP PPP3CA PPP3CB PPP3R1 NFATC1 DNM2 EGR1 JUND FOSB GBP5 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 SLA SLA2 SOCS2 SOCS6 SH2B3 IKBKE IRF7 TANK ACTR1A NEK2 CEP290 NFATC3 TUBB DCTN2 DCTN3 MEFV PSTPIP1 SUGT1 CALM3 CALM2 ATP8A1 IL34 GAB3 ATP11B ATP11A CARD11 MALT1 ATP8B4 RELB CLEC7A CARD9 MAP3K14 GBP6 ANO6 CENPX KIF23 KIF20A DGAT1 FABP5 PRL SNCA DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 SIKE1 IL21 IL5RA CSF2RB CSF2RA IL21R LGALS9 HAVCR2 IL15RA CD36 STAT5B IL15 IL5 IL3RA IL2RB IL9 GRB2 IL9R TNF CEBPD STAT6 POLR1C POLR1D AGPAT2 GM2A ARSA ASAH1 PSAP TKFC MBL2 GLA IL17RC IL17RA IL17F IL17A CRK UBE2L3 FADD CD14 GSDMD GSDME SPTAN1 DBNL RIPK3 IL18 IL1A IL1B PELI1 TLR4 GSN FNTA TICAM2 TICAM1 PKP1 LY96 SDCBP MAOA HMGB1 CASP8 CASP5 CASP4 DSP IRF1 IRF2 DSG1 NCSTN ADAM10 PSEN1 FBXL18 FBXL7 DNM1 FCER2 DNM3 MAPK12 MAPK13 SDC1 HPSE GH1 LYN INPP5D PIK3CG PIK3R6 PIK3R5 BTK ARF1 RALA RPLP0 PITPNA BOLA2B CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 JAK1 CISH IL12RB2 HSPA9 IL10 SERPINB2 SOCS5 ANXA2 GSTO1 AIP MSN TALDO1 TYK2 MIF SOD1 MTAP VAMP7 GSTA2 CAPZA1 PDCD4 PSME2 LCP1 AAMP PPIA AHCYL1 KPNA2 PRKCE MEF2A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ADAM17 CYFIP2 HMOX2 TEC STK10 FLT3 IRS1 IRS2 EIF4E3 IFIT1 PIK3CB TCIRG1 PPM1B EIF4E2 FLNB FGF2 CAPZB MX2 MX1 EIF4G3 EIF4G2 NCK1 AKT2 GRB10 ATP6V1E1 CTSD ATP6V1E2 HRAS WASF3 ATP6V1G1 ATP6V0B ATP6V0E1 CD180 LY86 ATP6V1G2 PTPN13 EEA1 PDPK1 TASL RBSN FLT3LG IRF5 GAB2 PIK3CA PIK3R3 ATP6V1B2 TLR9 PIK3C3 TRIB3 ATP6V0D1 FAF2 SOS1 SH3RF1 ATP6V0C ATP6V0D2 ATP6V1B1 RAC2 ATP6V1A SHC1 MUC13 PIK3R4 RHOG PIK3R2 PIK3R1 RHOF NRAS RHOU ATP6V0A2 THEM4 ATP6V1H MAPK1 ATP6V0A4 PANX1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ELMO2 ATP6V0A1 MAPK3 PTPN1 PTPN11 PLD2 UNC93B1 TLR3 CAMK2B CAMK2D SRC CAMK2A CKAP4 ZAP70 LRRC7 CALM1 DOCK2 CAMK2G DOCK1 ANAPC7 MOSPD2 UBE2C PTK2B UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 MRE11 ARMC8 FBXW11 OPTN SEM1 APP F13A1 LAMP2 HGF ARG1 SERPING1 PGLYRP4 PGLYRP3 STXBP2 DEFB105B PGLYRP2 KIF5C LEAP2 DEFB1 A1BG CLU HTN1 DEFB109B KIFAP3 S100A7A HSPA5 HTN3 BPIFA1 BPIFA2 GNLY CTSG CCR6 PPBP EPPIN ATP7A PRSS3 PGLYRP1 PRSS2 CAMP CCR2 DEFB106B DEFB119 DCD DEFB118 KIF3B SERPINA3 DEFB117 ORM1 DEFB116 SLC11A1 KIF3C SERPINA1 DEFB115 DEFB114 RNASE6 DEFB113 KIF4B DEFB112 ORM2 RNASE3 KIF4A DEFB110 TLR1 DEFB130A BPI KIF11 PRTN3 QSOX1 TIMP1 DEFB130B S100A9 CAP1 DEFB4B S100A8 KIF15 AHSG LTF TLR2 S100A7 DEFB103B REG3A DEFB129 CD63 DEFB131A DEFB128 DEFB127 DEFB126 DEFB125 ITLN1 DEFB124 KIF22 DEFB123 STX4 REG3G DEFB121 DEFB107B ART1 PDZD11 RNASE8 RNASE7 DEFA1B PI3 ELANE DEFB104B CHGA DEFA6 DEFA4 DEFA5 PLA2G2A S1PR1 DEFB136 DEFB135 DEFA3 DEFB134 DEFB133 DEFB132 LYZ DEFB108B DEFB108C CAPN1 ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 KIF26A ACLY ATG5 ATG12 SLC27A2 TCF7L2 CDKN1A TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ACAA1 EIF2S2 EIF2S1 EIF2S3 ATF3 TREM2 TNRC6C MOV10 MYCN STX1A AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 HMOX1 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 SPTBN2 PSMD1 NUP214 IDH1 PRKCD YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 HSPA8 ICAM1 TNFSF13 VAMP2 ADRM1 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HSPA1A EIF4G1 CASP9 APAF1 CASP3 CFD C3 GZMM CFB FURIN VAPA IL1RL1 IL33 CCT2 ROCK1 CUL3 KIF3A VCAM1 RBBP6 VIM AP1G1 ZBP1 AP1S2 TREX1 AP1S1 DDX41 ITGB7 AP1S3 DTX4 TBK1 B2M AP1M2 IRF3 AP1M1 STING1 AP1B1 NLRP4 TRIM32 HLA-A TRIM21 CD8B TRIM56 ELMO1 CD28 HEXB TNFRSF1A GLB1 NLRC3 IFI16 GUSB ARSB HSP90AA1 NEDD4 MKRN1 FRK CBL PLCG1 CDKN1B FZR1 FNTB SKP2 CDK4 H2AX CSF3R H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 IL6R H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 CHRNB4 MYLIP NEU1 FBXL21P CTSA REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 95%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 F9 PROC F10 PROS1 FURIN PROZ F2 BGLAP GAS6 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 95%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2CB PFKFB1 PPP2R5D PPP2R1B MLXIPL PPP2R1A ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 95%9686114 Activation of inflammatory caspases SERPINB1 IL18 CASP5 IL1B CASP4 CALM3 CALM2 GSDMD CALM1 CASP3 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 95%937039 IRAK1 recruits IKK complex IKBKB CHUK IRAK1 PELI3 UBE2V1 PELI2 TRAF6 PELI1 UBE2N IKBKG REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.6 Regulation of ornithine decarboxylase (ODC) PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 NQO1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 ODC1 OAZ1 OAZ2 ADRM1 OAZ3 AZIN1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702614 ponatinib-resistant FLT3 mutants FLT3 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) EBP DHCR7 SC5D DHCR24 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ARHGDIA NGFR LINGO1 MAG OMG RTN4 MCF2 RHOA NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism CD38 BST1 NMNAT3 NMNAT2 NMNAT1 NUDT12 NADK NNMT NAPRT NADSYN1 NMRK2 NMRK1 NAXE NADK2 NAXD NAMPT RNLS SLC22A13 NT5E QPRT SLC5A8 PARP10 SLC25A51 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle ARL6IP5 GAD1 GAD2 CHAT SLC18A3 SLC17A7 NAAA STX1A CASK LIN7A LIN7C LIN7B APBA1 SNAP25 RAB3A SLC32A1 SYT1 SLC6A13 ABAT GLS2 SLC6A1 CPLX1 RIMS1 UNC13B ALDH5A1 GLS DNAJC5 SLC22A2 SLC22A1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC1A1 SLC1A2 SLC1A3 SYN3 SLC1A6 SYN2 SLC1A7 HSPA8 VAMP2 SLC38A2 MAOA SYN1 SLC6A11 SLC6A12 SLC5A7 TSPOAP1 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle CLTC IQGAP1 PTK2B VANGL1 WWP2 ARHGEF7 PIK3R2 PIK3R1 RHOU ARHGEF6 STAM ARHGAP31 ARHGAP30 SPTAN1 STAM2 GIT1 TXNL1 HGS MYO6 CDC42 DEPDC1B NCK2 EPHA2 WDR6 NCK1 DST PARD6A DLG5 SRC ITSN2 PAK1 PAK3 SRGAP2 USP9X PAK2 PAK4 PEAK1 SPTBN1 GIT2 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair PCNA ERCC6 PCLAF REV1 ISG15 USP43 SPRTN MAD2L2 REV3L ISY1 FIRRM SIRT6 PNKP POLK POLE OGG1 PIAS3 UBE2T RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 UBE2L6 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 HERC2 ALKBH3 FTO ALKBH2 ALKBH5 ASCC1 ASCC2 ASCC3 CDK2 MAPK8 MDC1 FEN1 USP1 DTL UBE2I SUMO1 RBX1 TRIM25 NFRKB CCNH PIAS4 POLR2A POLR2B POLR2C BRCC3 POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J NPLOC4 POLR2K POLR2L MSH3 GTF2H1 GTF2H2 BAP1 GTF2H3 WDR48 GTF2H4 BABAM1 GTF2H5 BABAM2 CDK7 ERCC3 POLI ERCC2 UIMC1 MNAT1 UFD1 ACTB UBB ACTL6A UBC DDB2 RPS27A FAAP100 FAAP24 FAAP20 UBA7 FANCM ERCC8 FANCL FANCA FANCB FANCE FANCG FANCF KPNA2 TP53 DCLRE1C RIF1 MCRS1 POLL NHEJ1 UBE2B POLM TDP2 TDP1 PARG APEX1 ADPRS POLQ KDM4B YY1 RUVBL1 USP7 ABL1 PMS2 MPG MUS81 GPS1 SLX4 EME1 INO80C EME2 INO80B GEN1 INO80E SLX1B VCP INO80D COPS4 SPIDR FANCI COPS2 FANCC CLSPN RNF4 FIGNL1 POLB RNF168 NSD2 CENPX ACTR5 RAD23A ACTR8 RAD23B MSH2 RTEL1 ABRAXAS1 USP10 TP53BP1 UVSSA H2AX TFPT LIG1 H2AB1 MSH6 H2AC19 POLD3 H2BC26 POLD4 H2AC14 POLD1 H2BC12L POLD2 DCLRE1B H2BC21 DCLRE1A POLN FAN1 RNF8 H2AC8 H2AC6 CHEK2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 NTHL1 TDG MBD4 ACD H2BC9 TINF2 H2AZ2 H4C9 TERF1 MGMT TERF2 H2BC8 H2BC5 SMUG1 NEIL3 XRCC6 H2BC3 AQR XRCC4 H3-4 NEIL2 XRCC5 PARP1 H2BC1 POT1 LIG4 TERF2IP PPP4R2 NEIL1 TIPIN H2AC20 TIMELESS ZNF830 PPP4C POLH RAD52 MLH1 KDM4A FANCD2 SUMO3 SUMO2 PIAS1 PRPF19 PAXIP1 SMARCA5 CENPS PRKDC BAZ1B XAB2 BLM MRE11 RAD18 BRCA1 BRCA2 RAD51AP1 ELL WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN TOPBP1 ATRIP BARD1 APBB1 RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 EYA4 PPP5C RMI1 TCEA1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 RAD17 RAD1 PPIE CCNA2 ATM CCNA1 DNA2 RAD9B RHNO1 ATR RAD9A SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KDR KANK1 ETV6 GOLGA4 BIN2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 95%77387 Insulin receptor recycling ATP6V0D1 ATP6V0C ATP6V0D2 ATP6V1B1 ATP6V1A INS ATP6V0A2 ATP6V1H ATP6V0A4 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 ATP6V0A1 PTPN1 INSR TCIRG1 IDE PTPRF ATP6V1E1 CTSD ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 ATP6V1B2 REGULATION OF RAS BY GAPS%REACTOME DATABASE ID RELEASE 95%5658442 Regulation of RAS by GAPs RASA3 RASA4 RASA2 NRAS CUL3 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 KBTBD7 PSMA4 PSMA1 NF1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 SPRED3 SPRED2 PSMB7 SPRED1 RASAL2 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A RASA1 ADRM1 SYNGAP1 PSMC5 PSMC6 HRAS SEM1 PSMC3 PSMC4 PSMC1 PSMC2 DAB2IP RASAL1 RASAL3 SIGNALING BY ALK IN CANCER%REACTOME%R-HSA-9700206.5 Signaling by ALK in cancer CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 95%1236974 ER-Phagosome pathway HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E PSME1 SEC61A2 SEC61A1 CHUK TIRAP TAPBP IKBKB SEC22B MYD88 CALR B2M HLA-A TLR1 VAMP8 S100A9 PSMB10 PSMD8 PSMD6 TLR6 S100A8 PSMD7 TLR2 PSMD2 PSMD3 PSMD1 PSMB8 PSMB9 PSMA5 STX4 CD36 PSMA6 SNAP23 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 BTK CD14 PSMD12 SEC61G PSMD11 PSMD14 SEC61B PSMD13 PDIA3 PSMA7 PSMB6 FGB S100A1 PSMB7 FGA PSMB4 TAP2 FGG PSMB5 IKBKG TAP1 TLR4 UBB PSMB2 PSMB3 UBC PSMB1 VAMP3 RPS27A LY96 PSME2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 HMGB1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB ACADL HADHA ECHS1 HADH SUMOYLATION%REACTOME DATABASE ID RELEASE 95%2990846 SUMOylation NR5A1 PCNA RELA DDX5 NPM1 EIF2AK2 NR3C1 SP100 HNRNPC ESR1 NFKBIA VDR MDM2 RORA NUP205 POM121 SENP5 NUP107 SENP2 NUP188 NOP58 AAAS NUP160 POM121C RNF168 NUP42 NUP85 SMC5 TPR SMC6 NUP62 NSMCE3 NSMCE2 NUP88 TRIM27 NSMCE1 NUP43 NSMCE4A RAE1 EID3 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 AURKA NUP153 NUP93 NUP50 HDAC7 NUP35 NUP54 MTA1 DAXX TP53BP1 NUP37 ZNF131 UHRF2 DDX17 CASP8AP2 MBD1 TOP2A SAFB TOPORS MRTFA PML PIAS3 EP300 CDCA8 XPC SMC1A SMC3 TOP2B STAG1 TOP1 STAG2 RAD21 RARA TDG HERC2 RXRA PARK7 H4C9 XRCC4 PARP1 RANGAP1 HDAC1 CDKN2A NR3C2 RAD52 INCENP MITF BIRC5 SIN3A NRIP1 NCOA1 MDC1 AURKB NR1H2 NCOR2 CHD3 BMI1 TFAP2B ING2 SUMO3 SUMO2 TFAP2C HNRNPK RING1 PIAS1 UBE2I HDAC4 NR4A2 SUMO1 HDAC2 L3MBTL2 SATB1 SATB2 RNF2 ZBED1 THRB SUZ12 CBX8 PHC2 PHC1 CBX5 CBX4 SENP1 IKBKE PCGF2 CBX2 PHC3 VHL NUP214 ZNF350 AR PIAS4 PPARGC1A NR2C1 NCOA2 CETN2 TRIM28 BLM NFKB2 HIPK2 BRCA1 WRN CTBP1 IKBKG RWDD3 UBA2 DNMT1 SAE1 CREBBP RPA1 DNMT3B FOXL2 HIC1 SP3 DNMT3A TP53 PGR PPARG PPARA DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.3 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME%R-HSA-9956522.1 OTC variants cause OTC deficiency OTC BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins CYP1A2 CYP1A1 ALOX15 LTA4H MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.5 MAP kinase activation RPS6KA1 JUN DUSP4 DUSP3 VRK3 DUSP6 PPP2R5D DUSP7 MAP3K7 MAPK7 NFKB1 MAPK1 MAPK8 CHUK MAP2K6 MAPK3 ATF2 IKBKB PPP2CA PPP2CB MEF2C IRAK1 TAB1 MAPKAPK2 TRAF6 UBA52 BTRC NOD1 ATF1 NOD2 MAP3K8 IKBKG PPP2R1B MAP2K3 UBB PPP2R1A RIPK2 MAP2K4 MAPKAPK3 UBC RPS27A FBXW11 UBE2V1 TNIP2 MAPK9 MAPK14 IRAK2 MAPK11 MAP2K7 MAPK10 TAB3 SKP1 TAB2 FOS ELK1 MAP2K1 MEF2A RPS6KA3 UBE2N RPS6KA5 CUL1 RPS6KA2 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 95%9026395 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition PTK6 CDKN1A CDC25A CCND1 CDK2 LIN54 LIN37 LIN9 WEE1 LIN52 MYC E2F4 E2F5 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 RBL2 CCNH PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 RB1 PSMD12 CDKN1B PSMD11 PSMD14 PSMD13 E2F1 RBBP4 PSMA7 SKP2 PSMB6 CABLES1 PSMB7 CDK7 TFDP1 CCNE2 PSMB4 TFDP2 MNAT1 PSMB5 CDK4 CCNE1 UBB PSMB2 PSMB3 CKS1B MAX UBC PSMB1 RPS27A AKT2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 CCNA1 CUL1 AKT3 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 95%380320 Recruitment of NuMA to mitotic centrosomes CEP41 TUBGCP4 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL CDK1 CEP250 NEK2 NUMA1 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG2 PPP2R1A TUBG1 HAUS2 HAUS1 CPAP MZT2B MZT2A NME7 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 MZT1 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 95%112043 PLC beta mediated events PRKCA PLCB4 GNAQ ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MAPK1 PRKACG PRKACA PRKACB PLA2G4A GNA14 PDE1B PDE1A GNA15 ITPR1 ITPR2 CAMK2B ITPR3 CAMK2D GNA11 PRKAR1B CAMK2A PRKAR2B PRKAR1A AHCYL1 PRKAR2A CAMK4 PDE1C PRKX CAMKK1 CAMKK2 GRK2 KPNA2 PRKCG PLCB3 PLCB1 NBEA PLCB2 CALM1 CAMK2G PRKCD INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 95%913531 Interferon Signaling IFNA2 TRIM6 TRIM5 IFNA8 TRIM2 TRIM3 ARIH1 XAF1 IFNA13 CIITA IFNA14 TRIM68 IFNA16 TRIM62 IFNA17 TRIM46 TRIM48 NPM1 TRIM45 TRIM35 TRIM38 OAS2 TRIM31 TRIM34 IFITM3 IFITM2 IFNA10 HSPA5 IFIT5 IFI35 IFNA21 IFI30 RAF1 IFIT3 IFNB1 IFIT2 EIF2AK2 TRIM29 ISG15 TRIM26 TRIM22 RSAD2 IFI27 TRIM17 TRIM14 TRIM10 SP100 IFI6 IFI44L MID1 ISG20 YBX1 PRKRA IRF8 IRF6 TARBP2 IRF9 IFNAR1 SAMHD1 PTAFR FLNA HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 HLA-DRB4 HLA-DPB1 KPNB1 HLA-DRA HLA-DRB3 HLA-DRB1 HLA-DQB2 HLA-DQB1 FNTA DNAJC3 STAT2 UBE2L6 HERC5 UBE2N ADAR IRF1 IRF2 HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E HSPA1L HSPA2 ATF6 HSPA1B SOCS1 EIF2S2 IFNGR1 EIF2S1 IFNGR2 EIF2S3 EGR1 IKBKB EIF4E UBE2I GBP5 SUMO1 PIM1 DUS2 PGGT1B GBP2 GBP4 GBP3 TRIM25 IRF7 PSMB8 NUP214 PRKCD SFN UBA52 IFIH1 JAK1 ACTB IKBKG UBB UBC TYK2 PTPN2 RPS27A FAAP100 FAAP24 HSPA8 ICAM1 FAAP20 UBA7 FANCM FANCL FANCA FANCB FANCE FANCG FANCF HSPA1A KPNA2 EIF4G1 TP53 KPNA7 FKBP5 KPNA4 KPNA5 GBP1 KPNA3 FURIN FCGR1BP SPHK1 MAP2K6 STAT1 MT2A VCAM1 FANCC B2M SMAD7 IRF3 MAVS HLA-A TRIM21 GBP6 RIGI NUP205 POM121 NUP107 NUP188 FCGR1A AAAS NUP160 POM121C NUP42 NUP85 TPR CENPX NUP62 NUP88 NUP43 RAE1 NEDD4 KPNA1 ILF2 NDC1 RANBP2 SEC13 PLCG1 NUP155 NUP133 NUP210 PDE12 NUP153 OASL NUP93 OAS1 FNTB NUP50 OAS3 BECN1 RNASEL NUP35 NUP54 NUP37 ACTG1 USP18 PPP2R1B PPP2R1A EIF4E3 IFIT1 PPM1B PML EIF4E2 FLNB MX2 MX1 EIF4G3 EIF4G2 NCK1 SOCS3 EIF4A2 EIF4A1 IRF5 EIF4A3 NCAM1 PPP2R5A STAT3 BST2 MAPK1 DHX9 PIN1 CHUK MAPK3 PTPN1 IP6K2 PTPN11 CD44 PPP2CA PPP2CB IFITM1 CAMK2B PIAS1 CAMK2D SNCA CAMK2A CASP1 EIF2AK3 CAMK2G CENPS IFNG ABCE1 UBE2E1 CDK1 JAK2 ILF3 PTPN6 IRF4 IFNA5 IFNA4 IFNA7 GBP7 IFNA6 TRIM8 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CLPS CEL LIPF PNLIP PNLIPRP3 PNLIPRP1 PNLIPRP2 HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 95%162909 Host Interactions of HIV factors AP2A1 AP2A2 NPM1 AP2M1 AP2S1 AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP2B1 AP1B1 HLA-A CD8B PACS1 ELMO1 CD28 NUP205 POM121 NUP107 NUP188 PSIP1 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 KPNA1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 HMGA1 NUP153 NUP93 BTRC NUP50 NUP35 NUP54 SLC25A5 SLC25A4 SLC25A6 NUP37 KPNB1 CD4 RCC1 RAC1 RANBP1 RANGAP1 ATP6V1H PSMD8 PSMD6 PSMD7 ELOB XPO1 ELOC PSMD2 RBX1 PSMD3 PSMD1 NUP214 DOCK2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 UBA52 PSMD12 ARF1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 CCNT1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 CDK9 RPS27A CUL5 ADRM1 PPIA HCK PSMC5 PSMC6 SEM1 LCK PSMC3 FYN PSMC4 PSMC1 PSMC2 SKP1 PAK2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 95%109606 Intrinsic Pathway for Apoptosis XIAP CYCS STAT3 DYNLL1 UACA BAK1 GZMB CDKN2A DYNLL2 MAPK1 BID PPP1R13B MAPK8 BCL2L11 MAPK3 BAD PMAIP1 YWHAB YWHAE AKT1 YWHAQ YWHAG YWHAH YWHAZ SFN GSDMD NMT1 GSDME PPP3CC BAX C1QBP E2F1 TP63 TFDP1 TFDP2 CARD8 BBC3 BCL2 BCL2L1 AKT2 BMF AVEN TP73 APIP TP53 CASP8 CASP9 PPP3R1 TP53BP2 CASP7 APAF1 DIABLO CASP3 AKT3 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species NCF1 PRDX2 CYCS NCF2 PRDX1 NCF4 NUDT2 CAT PRDX3 NOX5 ERO1A TXN2 GPX3 GPX6 GPX5 GPX8 SOD2 GPX7 ATP7A CYBB TXNRD2 CYBA PRDX6 ATOX1 SOD3 CCS TXNRD1 SOD1 P4HB GPX1 GSTP1 AQP8 TXN NOX4 GPX2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 95%5423599 Diseases of Mismatch Repair (MMR) MSH6 MLH1 PMS2 MSH2 MSH3 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 95%4549349 Defective ALG2 causes CDG-1i ALG2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 95%111932 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMKK1 CAMKK2 KPNA2 CAMK2B CAMK2D CALM1 CAMK2G CAMK2A REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 95%9842860 Regulation of endogenous retroelements ATF7IP ZNF547 ZNF224 MBD3 GATAD2B GATAD2A ZNF778 RBM7 ZNF454 CHD4 ZNF519 ZNF680 SMARCD1 SMARCD2 SMARCD3 MTA2 RBBP4 MTA1 MTA3 RBBP7 SMARCE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 MORC2 H2AC6 H2AC7 H2BC17 H2BC12 ZNF669 H2BC13 H2BC14 H2AJ H2BC15 ZNF425 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 ZNF141 HDAC1 ZNF382 H2AC20 ZNF418 ZNF354A ZNF136 ZNF649 EHMT2 EHMT1 CHD3 SUMO2 UBE2I DPF1 HDAC2 DPF2 DPF3 ZNF28 CBX5 ZNF273 SETDB1 SS18L1 ARID1A ARID1B ZNF816 ZNF610 SS18 SMARCB1 ZNF264 PPHLN1 TRIM28 ZNF30 ZNF257 SMARCC1 SMARCC2 ZNF33A MPHOSPH8 ACTB SPOCD1 ZNF331 ZNF93 ZCCHC8 ACTL6A MTREX TASOR ZNF708 ZNF324 ZNF534 PIWIL4 DNMT3L BCL7A ZNF320 BCL7C SMARCA2 BCL7B SMARCA4 ZNF765 DNMT3A ZNF317 C19orf84 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 95%388841 Costimulation by the CD28 family JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 MIB2 RNF185 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 PRR5 DPY30 YWHAG EED TRAC CD3G CD3E CD3D TRBV12-3 TRAV29DV5 TRBV7-9 GRAP2 TRBC1 BTRC HLA-DQA2 HLA-DQA1 HLA-DPA1 HLA-DRB5 TRAV19 HLA-DRB4 HLA-DPB1 TRAV8-4 HLA-DRA HLA-DRB3 CD4 HLA-DRB1 HLA-DQB2 HLA-DQB1 BRD4 PDCD1 RAC1 COPS5 VAV1 MAPKAP1 IRF1 RPN2 TCF7L2 TUSC3 TCF7L1 RPN1 LEF1 MAGT1 TCF7 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 PRKAG3 TMEM258 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MLST8 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 MTOR TEAD3 PSMD8 TEAD4 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 AKT1 PSMD1 HIF1A ICOSLG PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LYN PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 JAK1 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PAK1 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 PAK2 RICTOR CUL3 VCP STAT1 MAP3K14 CD28 WDR5 RBBP4 RBBP5 RBBP7 CDK4 PPP2R1B H2AX PPP2R1A PIK3CB H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 AKT2 H3-3B H3C8 H2AC8 H2AC6 PAK3 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ PDPK1 H2BC15 H2BC11 PIK3R3 KMT2A PIK3CA TRIB3 H3C15 PPP2R5E H2BC9 H2AZ2 H4C9 H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D STAT3 PPP2R5C PIK3R2 H2BC1 PIK3R1 NFKB1 PDCD1LG2 B3GNT3 H2AC20 SPOP THEM4 PTPN11 CDC42 PPP2CA PPP2CB SUZ12 GSK3B CD86 CD80 NFKB2 CSK CD274 MAP3K8 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 WWTR1 YES1 SEM1 LCK FYN SKP1 FOS CUL1 AKT3 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9663891 Selective autophagy MAP1LC3A CETN1 FUNDC1 PARK7 ATG5 TOMM20 ATG9A ATG12 ULK1 DYNLL1 TOMM7 ARL13B MFN1 TOMM5 DYNLL2 MFN2 TOMM6 TOMM22 HSF1 IFT88 VCP DYNC1I2 PRKAA2 PRKAG1 PRKAG2 PRKAG3 SQSTM1 PLIN3 DYNC1I1 TBK1 PRKAB2 DYNC1H1 PRKAB1 UBE2D2 UBE2D3 EPAS1 PINK1 USP30 VDAC3 VDAC2 VDAC1 UBE2L3 MAP1LC3B CFTR HSP90AA1 UBA52 HDAC6 PLIN2 TOMM70 UBB UBC DYNC1LI1 PEX5 RPS27A NBR1 DYNC1LI2 UBE2V1 OPTN PRKN HSPA8 CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B ATM MTERF3 UBE2N PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly APOC4 A2M APOC3 APOC2 APOC1 P4HB APOA2 ZDHHC8 APOA1 APOA4 APOB PRKACG PRKACA PRKACB APOE ABCA1 SAR1B MTTP CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 95%389357 CD28 dependent PI3K Akt signaling CD86 CD80 PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 RICTOR MAP3K8 PIK3CB MLST8 PIK3CD AKT2 MAP3K14 MTOR LCK CD28 FYN PRR5 PDPK1 AKT1 PIK3R3 PIK3CA MAPKAP1 AKT3 TRIB3 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation SLCO1B1 SLCO1B3 ABCC1 ABCG2 ALB GSTA1 UGT1A4 HMOX1 BLVRB HMOX2 ABCC2 BLVRA UGT1A1 FABP1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B2 SRD5A3 CGA HSD3B1 CYP17A1 HSD11B1 HSD11B2 STARD3NL CYP19A1 POMC CYP11A1 STS SRD5A2 SRD5A1 HSD17B1 CYP11B2 SERPINA6 HSD17B2 CYP11B1 TSPO LHB HSD17B3 HSD17B12 CYP21A2 FDXR STARD3 STARD4 STAR STARD6 AKR1B15 HSD17B14 FDX1 HSD17B11 FDX2 AKR1B1 TSPOAP1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 95%199920 CREB phosphorylation RPS6KA1 ATF1 MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer HDAC1 NEURL1B HES5 APH1A HDAC3 DLL4 MIB2 PSENEN NCSTN MIB1 APH1B HEYL PSEN2 NEURL1 ADAM10 MAMLD1 PSEN1 TBL1X RBPJ CDK8 NCOR2 NCOR1 TBL1XR1 JAG2 SNW1 MYC ADAM17 HDAC4 HDAC2 RBX1 HES1 CCNC HDAC5 UBA52 HDAC8 HDAC9 HDAC6 HDAC7 UBB CREBBP UBC MAML2 MAML1 RPS27A HEY1 KAT2B KAT2A HDAC10 EP300 HDAC11 HEY2 JAG1 DLL1 SKP1 MAML3 NOTCH1 CUL1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER PCNA AQR USP7 ZNF830 ERCC6 ISY1 PRPF19 RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H UBA52 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 UVSSA CDK7 ERCC3 ERCC2 MNAT1 UBB RFC5 UBC POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE POLD2 TCEA1 RFC2 RFC1 RPA1 ERCC8 DDB1 RPA2 XPA POLE4 CUL4A RPA3 PPIE ERCC4 ERCC1 POLE2 POLE3 ERCC5 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants CLTC JUN GCC2 STAT3 CARS1 PIK3R2 CDKN1A PIK3R1 HDAC1 NPM1 GZMB DCTN1 KLC1 PPFIBP1 MAPK1 EEF1G MAPK8 CEBPB RNF213 MAPK3 STAT1 SEC31A FOXM1 SQSTM1 TNRC6C MOV10 KIF5B AGO3 AGO4 AGO1 AGO2 MDM2 TFG RBX1 ZAP70 EML4 EIF2AK3 ATIC TPR PRF1 ICOS MCL1 STAT5A IL10RA ZC3HC1 CCNB1 RANBP2 BIRC6 GRB2 UBA52 PLCG1 FN1 RB1 BCL11A IL22 HIP1 TPM4 TPM3 IL10 RRBP1 IRS1 WDCP UBB PIK3CB LMO7 DNMT1 STRN PPM1B MSN UBC TYK2 VCL FRS3 RPS27A JUNB PTPN6 MAPK9 RPS6 ALK IRF4 PRKAR1A MYH9 BCL2A1 SKP1 TP53 TWIST1 FRS2 PIK3CA CUL1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%8980692 RHOA GTPase cycle ERBIN ARHGAP26 VANGL1 ARHGAP32 ROCK1 ROCK2 ARHGAP44 PREX2 ARHGAP40 ARHGDIA HMOX2 STARD8 ARHGAP8 ARHGAP45 AAAS ARHGEF25 CIT IQGAP1 PKN3 PLD1 IQGAP3 STX5 ARHGAP22 ARHGAP20 SRGAP1 STARD13 JUP VMA22 ARHGAP29 ARHGAP24 PKN2 PKN1 ARHGAP31 FAM13A STK10 ARHGAP30 SLK C1QBP ARHGAP9 ARHGAP11B TEX2 ARHGAP4 DDRGK1 TAGAP PLEKHG3 PLEKHG4 BCAP31 ARAP1 GMIP ARHGAP11A TJP2 ARHGAP10 DAAM1 TRIO RASGRF2 PLEKHG6 ARHGEF10L AKAP13 PREX1 STOM MCF2L ARHGEF40 FARP1 VAV3 PCDH7 MYO9B ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 DEF6 VAPB KTN1 ARHGEF15 PLEKHG5 DLC1 TMEM87A DIAPH1 ARHGEF17 FLOT1 ARHGEF19 SCFD1 DIAPH3 FLOT2 ARHGEF18 VAV1 VAV2 ANLN TIAM1 FAF2 OBSCN ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 PIK3R2 PIK3R1 ARHGEF5 NGEF KALRN RHOA EMC3 CAVIN1 MYO9A ABR RTKN ECT2 ARHGEF28 ARHGAP19 ARHGAP18 MCF2 NET1 RHPN1 RHPN2 ACBD5 MACO1 ARHGAP28 ARHGAP23 FMNL3 ABCD3 SOWAHC DOCK2 TFRC SNAP23 ARHGAP1 ARHGAP39 ACTC1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGAP42 OPHN1 STBD1 ARHGDIB LBR TMPO ARAP2 ARAP3 BCR DEPDC1B VAMP3 ARHGAP21 LMAN1 PGRMC2 RACGAP1 YKT6 CAV1 MCAM ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A4 SLC39A7 SLC39A2 SLC39A1 SLC39A3 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 95%5218859 Regulated Necrosis IRF1 XIAP IRF2 CYCS CHMP3 CHMP6 TNFRSF10B CHMP7 TNFRSF10A BAK1 GZMB ITCH FAS FASLG RIPK1 OGT CASP1 STUB1 UBE2L3 TRAF2 TNFSF10 HSP90AA1 CDC37 UBA52 BIRC2 FADD ELANE BIRC3 GSDMD GSDME BAX TP63 RIPK3 IL18 IL1A IL1B PELI1 UBB UBC RPS27A CHMP4C CHMP4B CHMP4A PRKN SDCBP MLKL CHMP2B CHMP2A TRADD HMGB1 TP53 CASP8 CASP5 CASP4 FLOT1 FLOT2 CASP3 PDCD6IP ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PREB KDELR1 KDELR3 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 KDELR2 SAR1B COPB2 TRAPPC4 COPA TMED10 SEC22B SERPINA1 SEC23A COPE ARF4 F5 TMED3 F8 SEC24B TMED7 TMED9 SEC24A COPZ2 BET1L STX5 COPZ1 USO1 ANKRD28 SEC13 PPP6C ARF5 PPP6R3 NAPA GBF1 NAPB SEC24D SPTAN1 RAB1A SEC24C TRAPPC1 RAB1B GOSR1 GOLGA2 NAPG MIA3 ARFGAP3 ARFGAP2 DYNC1LI1 CAPZB GORASP1 DYNC1LI2 ARCN1 TRAPPC2L COPG2 LMAN1L COPG1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 SEC16A TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 SCFD1 CNIH3 SPTBN1 MCFD2 MIA2 PPP6R1 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 DYNLL1 SEC23IP FOLR1 INS BET1 DCTN6 DCTN5 CTSZ DYNLL2 DCTN1 DCTN4 NSF CTSC CAPZA3 COL7A1 CAPZA2 DYNC1I2 ACTR10 ARF3 SEC31A TMED2 SPTB DYNC1I1 GRIA1 DYNC1H1 ANK2 ANK3 CD59 CD55 SPTBN4 TFG SPTBN5 SPTBN2 COPB1 ACTR1A ARF1 GOLGB1 SPTA1 CSNK1D ANK1 AREG DCTN2 CAPZA1 DCTN3 GOSR2 LMAN1 TGFA YKT6 ARFGAP1 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN PORCN RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 95%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression RXRA CREBBP CHD9 PPARGC1A NCOA2 NCOR1 NCOA6 TBL1XR1 EP300 SMARCD3 MED1 TGS1 HDAC3 RORC RORA NR1D1 NRIP1 CARM1 TBL1X NCOA1 CPT1A SREBF1 HELZ2 PPARA REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 95%9824878 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 UBC TICAM2 TICAM1 RPS27A TBK1 TRAF3 OPTN LY96 UBA52 CD14 IKBKE TANK UBB TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871837 FCERI mediated NF-kB activation RELA MAP3K7 RASGRP2 RASGRP1 IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 CARD11 IGKV2D-28 MALT1 IGKV4-1 IGHV7-81 NFKBIA IGKV2D-30 IGHV4-59 IGHV1-69 TAB1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV TRAF6 IGKV2-29 IGKV2-28 IGLC3 IGLC1 BTRC IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDPK1 PRKCQ UBE2N NFKB1 V2-11 V3-4 V3-3 V2-17 IGHE V3-2 V2-15 V2-19 CDC34 V1-11 V1-16 V1-13 CHUK V2-8 IKBKB V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 UBE2D2 PSMD8 PSMD6 PSMD7 V4-6 PSMD2 V4-2 V4-1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 LYN PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 UBE2V1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 TAB3 SKP1 TAB2 RASGRP4 CUL1 METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196854 Metabolism of vitamins and cofactors LDLRAP1 CUBN AMN APOA2 ACO1 APOA1 ABCD4 APOA4 SLC2A1 PRKG2 PRSS3 LPL LMBRD1 LDLR GPIHBP1 APOC3 LRP8 FLAD1 RFK SLC52A2 APOB SLC52A3 ACP5 SLC52A1 NOS3 ENPP1 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR PDZD11 GCHFR GCH1 SPR PTS NNMT PNPO AOX1 NAMPT SLC5A6 ACACA STARD7 FASN COQ9 COQ7 COQ6 COQ5 COQ4 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A SDC4 SDC2 SDC3 SLC46A1 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 SDC1 AKT1 IDH1 COQ2 GSTO1 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC PCCA HLCS MCCC1 PCCB ACACB NUDT12 NADK CYB5R3 THTPA TCN1 NMRK2 NMRK1 RBP4 NAXE RBP1 LRAT NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MOCOS MMAB SLC22A13 QPRT SHMT2 MTRR SLC25A51 SLC25A19 CD38 GPHN HSP90AA1 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 NMNAT1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN2 PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 TCN2 CD320 AKR1C1 TTR CBLIF AKR1C4 MMACHC MMADHC PLB1 BST1 VNN1 HSPG2 APOE GSTO2 AGRN APOC2 ABCC1 MTR SLC2A3 CALM1 VKORC1L1 UBIAD1 LRP1 RETSAT APOM TTPA BCO2 BCO1 VKORC1 AKR1B10 NAPRT CLPS RBP2 LRP10 LRP12 PNLIP PDXK NADK2 RDH11 AKR1C3 SLC5A8 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%75953 RNA Polymerase II Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 95%379716 Cytosolic tRNA aminoacylation YARS1 EEF1E1 KARS1 EPRS1 NARS1 IARS1 PPA1 TARS1 AARS1 CARS1 HARS1 FARSA FARSB RARS1 LARS1 AIMP1 AIMP2 WARS1 QARS1 MARS1 GARS1 DARS1 SARS1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation DUSP9 DUSP4 TYK2 DUSP6 DUSP7 DUSP10 IL6R CDK1 IL6 PEA15 MAPK1 DUSP5 DUSP2 DUSP1 JAK2 DUSP16 JAK1 MAP2K1 MAP2K2 MAPK3 PTPN11 DUSP8 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 95%190827 Transport of connexins along the secretory pathway GJA1 GJB2 GJB1 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC25A19 SLC19A3 SLC19A2 THTPA TPK1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 95%174154 APC C:Cdc20 mediated degradation of Securin PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 PSMA5 UBE2C PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 PSMA1 ANAPC10 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 CDC20 PSMB5 UBB PSMB2 PTTG1 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA1 GRIA2 GRIA3 GRIA4 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends HERC2 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 PPP4R2 TIPIN TIMELESS PPP4C CDK2 MDC1 CLSPN SUMO2 UBE2I RNF4 RNF168 NSD2 PIAS4 BRCC3 UBA52 BLM MRE11 ABRAXAS1 BRCA1 BABAM1 TP53BP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 H2AX NBN UBB TOPBP1 SIRT6 ATRIP BARD1 RFC5 UBC RMI2 H2BC26 RFC3 RFC4 RPS27A H2BC12L RMI1 H2BC21 RFC2 TOP3A RNF8 RPA1 HUS1 RPA2 UBE2V2 H2BC17 RAD50 H2BC12 H2BC13 H2BC14 RPA3 H2BC15 RAD17 CCNA2 RAD1 CCNA1 H2BC11 ATM DNA2 RAD9B RHNO1 ATR UBE2N RAD9A BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 95%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA EXOSC9 EXOSC8 EXOSC3 XRN1 EXOSC2 EXOSC1 MAPKAPK2 DCP2 YWHAB DCP1A ZFP36L1 EXOSC7 EXOSC6 AKT1 EXOSC5 EXOSC4 DIS3 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%975578 Reactions specific to the complex N-glycan synthesis pathway CHST8 CHST10 FUT3 FUT8 MAN2A2 CGA MAN2A1 LHB MGAT2 FUCA1 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.2 Defective F9 secretion F9 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 95%9830369 Kidney development ROBO2 WFDC2 MECOM GFRA1 OSR1 GATA3 HOXA6 BMP4 PAX8 PLAC8 FOXC2 ITGA8 CTNNB1 FOXC1 SIX1 HOXD11 NPNT HOXC11 GDNF PAX2 RET HOXA11 GREM1 SALL1 SIX2 EYA1 FGF2 HOXB4 IRX1 ID4 LFNG IRX2 JAG1 SLIT2 WT1 LHX1 HNF4A WNT9B HNF1B DLL1 POU3F3 WNT4 WNT11 ITGB1 EMX2 PCDH19 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 FZD2 CLTC CLTB FZD5 WNT5A AP2S1 ROR1 CLTA ROR2 AP2A1 AP2A2 AP2B1 AP2M1 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 95%1237044 Erythrocytes take up carbon dioxide and release oxygen CA4 AQP1 CYB5R2 CYB5R4 HBA2 CYB5RL SLC4A1 CA1 RHAG CYB5R1 CA2 HBB CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.5 Crosslinking of collagen fibrils PXDN LOXL1 PCOLCE LOXL2 TLL2 TLL1 LOX LOXL3 LOXL4 BMP1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 95%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways YWHAH SFN YWHAZ YWHAE PDPK1 AKT1 AKT2 YWHAQ CAV1 YWHAG YWHAB AKT3 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 95%8875878 MET promotes cell motility ITGA3 CRK LAMA5 LAMA2 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 RAP1B RAP1A ITGA2 MET DOCK7 RAPGEF1 TNS4 TNS3 SRC RAC1 GAB1 HGF PTK2 CRKL ITGB1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 HEME SIGNALING%REACTOME DATABASE ID RELEASE 95%9707616 Heme signaling RXRA PPARGC1A NCOA2 NCOA6 SMARCD3 HDAC3 HBB APOA1 NR1D1 NRIP1 CRTC2 TBL1X CARM1 CRTC3 BMAL1 CRTC1 NCOA1 ATF2 BACH1 CLOCK NPAS2 TLR4 HELZ2 RAI1 CREBBP CHD9 MAFK NCOR1 SLC46A1 MEF2C TBL1XR1 NFE2L2 EP300 LY96 CLEC1B MED1 TGS1 MEF2D PGRMC2 APOB HBA2 RORA HMOX1 SIRT1 XPO1 PPARA CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 95%389359 CD28 dependent Vav1 pathway CDC42 LCK CD28 RAC1 FYN CD86 CD80 PAK2 VAV1 PAK1 PAK3 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 95%1839120 Signaling by FGFR1 amplification mutants CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.5 Clathrin-mediated endocytosis CLTC CLTB WNT5A CLTA AP2A1 AP2A2 ARPC1A LDLRAP1 AP2M1 BIN1 STAM2 ARPC4 STON1 GPS1 ARPC5 STON2 ARPC2 ARPC3 SNX18 COPS4 ACTR3 ACTR2 ADRB2 COPS2 KIAA0319 TF TOR1A TOR1B AVPR2 AAK1 CTTN SGIP1 AP2S1 AGTR1 DNAJC6 FCHO1 LDLR FCHO2 UBQLN1 UBQLN2 HIP1R AP2B1 NECAP2 NECAP1 SYT11 AGFG1 ITSN2 FNBP1L SNX9 APOB SNAP91 M6PR SYT2 GAK ARRB1 FNBP1 ARRB2 SCARB2 AMPH PACSIN2 PACSIN3 PACSIN1 SYT8 EPN2 SH3KBP1 SLC2A8 REPS2 EGF CBL REPS1 CD3G EGFR CD3D VAMP4 RAB5B RAB5C TGOLN2 CHRM2 ARF6 HGS RAB5A WASL CD4 GAPVD1 ITSN1 COPS7B COPS7A DVL2 COPS3 COPS6 COPS5 COPS8 FZD4 HBEGF CLTCL1 TRIP10 DNM1 SLC18A3 DNM2 DAB2 EPS15L1 EPN1 PIK3C2A SYT9 GRK3 PICALM VAMP8 DNM3 IL7R TFRC PIP5K1C CFTR SYT1 IGF2R UBA52 STAM HIP1 OCRL UBB SYNJ2 SYNJ1 UBC VAMP3 RPS27A SH3GL3 AREG VAMP7 EPS15 SH3GL2 SH3GL1 HSPA8 AVP VAMP2 NEDD8 TACR1 GRK2 TGFA LRP2 EREG ARFGAP1 BTC EPGN HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state EVC2 IQCE EFCAB7 EVC BOC GAS1 DRC4 CDON SPOP ITCH CUL3 KIF7 IHH SMO GPR161 KIF3A PTCH1 GLI3 GLI2 SMURF2 SMURF1 PSMD8 PSMD6 PSMD7 ARRB1 PSMD2 RBX1 ARRB2 PSMD3 PSMD1 CSNK1A1 PSMA5 PSMA6 CDC73 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 GLI1 SUFU PSMD14 NUMB PSMD13 PSMA7 PSMB6 SHH DHH PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 HHIP PSMC1 PSMC2 ULK3 GRK2 DZIP1 SPOPL REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 95%8866376 Reelin signalling pathway FYN SH3KBP1 VLDLR RELN DAB1 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance APOB LDLR APOE LIPC LDLRAP1 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation RXRA MED19 MED18 SREBF2 MED11 RELA WNT1 NFKB1 MED9 MED29 KLF5 MED28 MED22 TGFB1 MED21 HDAC3 CDK19 CEBPB TBL1X MED13L ANGPTL4 PCK1 NCOA1 LPL EGR2 FABP4 CDK8 NCOR2 NCOR1 TBL1XR1 PLIN1 THRAP3 LEP FAM120B CD36 PPARGC1A NCOA2 NCOA6 NCOA3 CCNC SMARCD3 CCND3 CARM1 ADIPOQ CDK4 MED16 HELZ2 MED15 KLF4 MED17 CREBBP CHD9 MED12 MED14 MED13 TNF MED10 EP300 EBF1 WNT10B NR2F2 ADIRF SLC2A4 MED1 MED30 ZNF638 TGS1 CEBPD MED31 ZNF467 MED8 MED4 MED27 MED6 MED26 MED7 MED23 MED25 CEBPA MED24 MED20 PPARG PPARA DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1B SNAP25 STX1A PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 95%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters CREBBP BMAL1 KMT2A CLOCK TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 95%8878171 Transcriptional regulation by RUNX1 YAP1 SERPINB13 ABL1 ITCH GPAM ARID2 ESR1 AUTS2 IL2 IL3 TCF3 LDB1 SIN3B DPY30 WDR5 CR1 ELF1 ELF2 SMARCD1 SMARCD2 FOXP3 SMARCD3 CCND3 CCND2 RBBP5 CDK6 BLK SMARCE1 KMT2D H2AX SPI1 PML H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 MYB EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 PRKCB H2BC17 RUNX1 H2BC12 H2BC13 H2BC14 H2AJ ZFPM1 H2BC15 PRKCQ TAL1 H2BC11 KMT2A CBFB ITGA2B SOCS4 GATA2 H3C15 OCLN H2BC9 H2AZ2 H4C9 H2BC8 PRMT6 H2BC5 NFE2 H2BC3 H2BC1 PRMT1 HDAC1 H2AC20 GP1BA SETD1B SETD1A NFATC2 CCND1 SIN3A TJP1 LMO1 YAF2 LMO2 PTPN11 LIFR KCTD6 TNFRSF18 ASH2L TNRC6C MOV10 AGO3 BMI1 CBX6 AGO4 RING1 AGO1 AGO2 RSPO3 SRC TNRC6A TNRC6B CLDN5 NR4A3 RNF2 PSMD8 PSMD6 CBX8 PSMD7 PHC2 TCF12 MYL9 PHC1 PAX5 PSMD2 CBX4 PSMD3 CBX2 PSMD1 PHC3 ARID1A IL2RA ARID1B GATA1 AXIN1 IFNG CCNH PSMA5 PSMA6 PSMA3 GATA3 PSMA4 THBS1 PSMA1 SMARCB1 PSMA2 LGALS3 UBA52 PSMD12 PSMD11 PCGF5 PSMD14 PSMD13 PSMA7 HIPK2 SMARCC1 SMARCC2 PSMB6 RYBP CDK7 PSMB7 PSMB4 MNAT1 PSMB5 PF4 UBB PSMB2 CSF2 ACTL6A PSMB3 CREBBP UBC PSMB1 RPS27A KAT2B CTLA4 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 SMARCA2 PSMC4 SMARCA4 ACTL6B PSMC1 CSNK2B PSMC2 TP73 CTSV CTSL CTSK PBRM1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 95%68867 Assembly of the pre-replicative complex ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KPNA1 FZR1 KPNB1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KPNA6 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 ANAPC15 ANAPC16 ANAPC7 UBE2C PSMA5 PSMA6 UBE2E1 PSMA3 UBE2D1 PSMA4 ANAPC10 PSMA1 ANAPC11 PSMA2 CDC23 UBE2S CDC26 UBA52 CDC27 PSMD12 CDC16 PSMD11 ANAPC4 ANAPC5 PSMD14 ANAPC1 ANAPC2 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 MCM7 PSMC2 MCM8 GMNN MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK2 KCNK10 KCNK4 ALPHA-DEFENSINS%REACTOME DATABASE ID RELEASE 95%1462054 Alpha-defensins DEFA5 DEFA3 ART1 DEFA1B PRSS3 PRSS2 CD4 DEFA6 DEFA4 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNB4 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 CHRNA9 CHRNA6 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME%R-HSA-442982.5 Ras activation upon Ca2+ influx through NMDA receptor RASGRF2 CAMK2B NRAS CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 95%9759218 Cobalamin (Cbl) metabolism MTR MTRR MMAA MMUT MMAB MMACHC MMADHC DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 95%72202 Transport of Mature Transcript to Cytoplasm SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CPSF4 CHTOP SLBP CPSF1 ALYREF DDX39B CPSF3 CPSF2 SRRM1 DHX38 NXF2B SYMPK NXT1 UPF3B MAGOHB EIF4E RNPS1 NUP205 WDR33 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 FIP1L1 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m DOLK DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 95%5609977 Defective GALE causes EDG GALE DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 95%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 95%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide VCP TCF25 ANKZF1 KLHDC10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 NEMF RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 UBE2D2 RPL12 PSMD8 RPL11 PSMD6 RPL36A RPL14 PSMD7 ELOB RPL13 ELOC RPL15 PSMD2 RBX1 RPL18 RPL17 PSMD3 RPL19 CUL2 RPL39L PSMD1 RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 PSMA5 RPL26L1 PSMA6 PSMA3 UBE2D1 PSMA4 PSMA1 PSMA2 LTN1 UBA52 PSMD12 NPLOC4 PSMD11 RPLP0 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 UFD1 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 95%70895 Branched-chain amino acid catabolism ACADSB ACAD8 MCCC2 ECHS1 ACAT1 MCCC1 BCAT1 SLC25A44 BCAT2 ALDH6A1 HIBADH PPM1K BCKDK BCKDHA AUH BCKDHB IVD DBT HIBCH HSD17B10 DLD GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.3 Glycine degradation OGDH KGD4 GCSH GLDC AMT DLST DLD CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.7 Cilium Assembly CEP41 CEP43 IFT172 KIFAP3 CCT2 IFT52 IFT57 DYNC2H1 TUBA1A IFT140 RPGRIP1L CCT3 PRKACA WDR35 IFT88 SMO TCP1 KIF3A TTC21B WDR19 IFT122 KIF3B MKS1 KIF3C ARF4 PKD2 CCT8 PKD1 CCT5 BBS9 CCT4 CNGA2 BBS7 CEP97 YWHAE CNGA4 TUBB4B KIF17 BBS5 TUBB4A BBS4 MKKS EXOC8 EXOC7 CYS1 SSTR3 LZTFL1 BBS10 YWHAG BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 UNC119B HSP90AA1 ARL6 ARL3 ASAP1 MCHR1 NPHP3 RAB11FIP3 BBS2 BBS1 GBF1 RAB3IP BBIP1 HDAC6 RHO RAB11A ATAT1 TTC8 CNGB1 PPP2R1A CPAP DYNC2I2 DYNC2I1 TRAF3IP1 IFT80 IFT81 TRIP11 DYNC2LI1 IFT70B IFT70A PRKAR2B DYNLT2B IFT20 IFT22 IFT27 DYNLRB2 DYNLRB1 IFT25 IFT56 DYNLT5 DYNLT2 IFT43 IFT46 IFT74 CLUAP1 DYNLL1 CKAP5 ARL13B INPP5E DYNLL2 PDE6D MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 C2CD3 TCTN3 CCP110 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 TMEM216 FBF1 B9D2 TTBK2 TMEM67 NPHP1 NPHP4 TNPO1 MARK4 SEPTIN2 SCLT1 AHI1 CEP162 CEP83 PLK1 B9D1 CEP89 CEP57 CETN2 CEP164 ACTR1A PCM1 CDK1 CNTRL CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 HAUS2 HAUS1 AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 DCTN3 RAB8A HAUS8 HAUS7 CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DDX21 NOP58 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 RPP30 RPP38 RPP21 RPP25 RPP40 TRMT112 RPP14 DIS3 UBA52 RPLP0 LTV1 RRP1 FTSJ3 EXOSC7 EBNA1BP2 ISG20L2 ERI1 EXOSC6 CSNK1D LAS1L NOL12 EXOSC5 RBM28 CSNK1E EXOSC4 NOB1 RIOK2 RIOK1 TEX10 EXOSC9 SENP3 GNL3 C1D NIP7 EXOSC8 NOL9 RPS27A EXOSC10 EXOSC3 PES1 EXOSC2 EXOSC1 RIOK3 WDR18 WDR12 BYSL BOP1 TSR1 MPHOSPH6 XRN2 NOP56 GAR1 NHP2 NOP10 DKC1 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 RPS27 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 UTP25 HEATR1 TSR3 RPL4 NOC4L RPL5 NOL6 RPL30 RRP7A RPL3 EMG1 RPL32 PDCD11 RPL31 BMS1 DHX37 RPLP1 RPL34 RRP36 RPL10L UTP20 RPL8 SNU13 DCAF13 RPL10A NOP14 RPL6 UTP6 RPL7 UTP4 RPL7A KRR1 RPL18A UTP3 RPL36AL PNO1 RPL36 RCL1 TBL3 RPLP2 RPL35 MPHOSPH10 RPL38 NOL11 RPL37 RPL39 NOP2 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 MTREX NCL ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 95%9645460 ALPK1 signaling pathway UBC TAB3 RPS27A ALPK1 TAB2 MAP3K7 TRAF6 UBA52 UBB TIFA TAB1 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NTRK1 NGF PLCG1 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 95%171007 p38MAPK events HRAS MAPKAPK3 RALGDS RALB MAPK12 MAPK13 MAPKAPK2 NRAS MAPK14 MAPK11 RALA SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions DPYSL3 ITGA1 RHOC HSP90AB1 RHOA RHOB ROCK1 ROCK2 PLXNC1 MET SEMA6A PLXNA4 SEMA6D SEMA7A CDK5R1 PLXNB3 TREM2 SEMA3E SEMA4A CDK5 SEMA5A RND1 MYL9 GSK3B TYROBP SEMA3A RRAS FES PLXNA2 PIP5K1C PLXNA3 FARP2 HSP90AA1 ERBB2 CD72 ARHGAP35 PLXND1 CFL1 PTPRC PLXNA1 PLXNB1 TLN1 SEMA4D PAK1 PAK3 LIMK2 RAC1 LIMK1 MYL12B FYN MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 MYH10 PAK2 NRP1 CRMP1 ITGB1 DPYSL4 DPYSL5 DPYSL2 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 95%428157 Sphingolipid metabolism CYB5B VAPA GAL3ST1 CERK GBA3 GBA2 MFSD2B SMPD3 SMPD2 SPHK1 STS SMPD4 GM2A SMPD1 A4GALT ENPP7 ARSA SUMF2 PLPP3 SUMF1 PLPP2 B3GNT5 PLPP1 B4GALT6 B4GALT5 ASAH1 ASAH2 FUT2 FUT1 UGCG UGT8 SGPL1 ARSL ARSJ ARSK PSAP ARSH ARSI ARSF B4GALNT1 ARSG ACER2 HEXB ARSD ACER1 HEXA B3GALNT1 GLB1L3 B3GALT4 M6PR ACER3 GLB1L2 GALC GLA GLB1L GLB1 SPTLC1 ARSB SPTLC2 SPTLC3 ORMDL2 ORMDL3 SPTSSB SPTSSA ORMDL1 VAPB PRKD3 PRKD2 PRKD1 SPNS2 ABCG2 ALDH3B2 ALDH3B1 FA2H DEGS1 DEGS2 SPHK2 SAMD8 SGMS1 ABCC1 SGMS2 OSBP SGPP2 SGPP1 CSNK1G2 KDSR ST6GALNAC5 ST6GALNAC6 GBA1 NEU2 NEU3 NEU1 ST8SIA5 ST3GAL5 CERS3 ST3GAL2 CERS4 ST3GAL3 CERS5 CTSA CERS6 CERS1 CERS2 PPM1L SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen MINPP1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA14 GNAQ GNA15 PLCB3 PLCB1 FFAR1 PLCB2 GNA11 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427601 Inorganic anion exchange by SLC26 transporters SLC26A2 SLC26A3 SLC26A9 SLC26A6 SLC26A11 SLC26A1 SLC26A4 SLC26A7 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 95%8866423 VLDL assembly APOC4 APOB APOC1 MTTP P4HB M PHASE%REACTOME%R-HSA-68886.5 M Phase PRKACA YWHAE EML4 CDCA5 NCAPG YWHAG ARPP19 NCAPH ENSA SIRT2 USO1 NCAPD2 TUBB8 RAB2A IST1 VRK1 LEMD2 TUBB8B NUMA1 FIRRM ESPL1 RAB1A RAB1B GOLGA2 FBXO5 BLZF1 KPNB1 SPAST CC2D1B CNEP1R1 PTTG1 MASTL GORASP2 GORASP1 PPP2R2D CHMP4C CHMP4B CHMP4A PRKAR2B PRKCB CHMP2B CHMP2A CHMP3 CHMP6 CHMP7 UBE2I SUMO1 CCP110 PSMD8 PSMD6 PSMD7 XPO1 PSMD2 PSMD3 PSMD1 TNPO1 NUP214 PRKCA PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RAN PSMA2 CEP57 CETN2 UBA52 CEP164 ACTR1A PCM1 PSMD12 CNTRL PSMD11 SET CEP250 NEK2 PSMD14 CEP290 NINL PSMD13 CDK5RAP2 EMD OFD1 PSMA7 LBR CEP135 TUBB PSMB6 CEP131 PSMB7 HAUS4 HAUS3 CSNK1D PSMB4 HAUS6 PSMB5 HAUS5 CSNK1E TUBG2 LEMD3 UBB TUBG1 PSMB2 PSMB3 TUBB6 HAUS2 TUBB3 HAUS1 MZT2B TUBB1 UBC MZT2A PSMB1 NME7 AKAP9 RPS27A CEP63 SFI1 SDCCAG8 DCTN2 TUBGCP2 SSNA1 ADRM1 CSNK2A1 DCTN3 HAUS8 PSMC5 HAUS7 CSNK2A2 CEP70 PSMC6 CEP72 PSMC3 TUBA4B CEP192 PSMC4 PCNT PSMC1 TUBA4A CSNK2B CEP76 PSMC2 CEP78 PLK4 CCNB2 ODF2 NEK9 CEP152 NEK6 MZT1 NEK7 NEDD1 ALMS1 TUBGCP5 TUBGCP6 TUBGCP3 CEP41 TUBGCP4 CEP43 TUBA8 TUBA1C TUBA1B TUBA1A LMNB1 TUBB2B TUBB2A TUBAL3 TUBA3E NCAPG2 SMC4 SMC2 TUBA3D NCAPH2 NCAPD3 TUBA3C MCPH1 ANKLE2 TUBB4B TUBB4A NUP205 POM121 NUP107 NUP188 AAAS KMT5A NUP160 POM121C NUP42 NUP85 TPR NUP62 BANF1 NUP88 NUP43 RAE1 HSP90AA1 NDC1 RANBP2 SEC13 NUP155 NUP133 RB1 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B H2AX PPP2R1A KNTC1 CPAP KNL1 H2AB1 H2AC19 SGO1 DYNC1LI1 H2BC26 H2AC14 SGO2 H2BC12L DYNC1LI2 RCC1 H2BC21 ZW10 MAD1L1 H3-3B CDCA8 H3C8 H2AC8 PMF1 SKA1 H2AC6 SKA2 KIF23 H2AC7 DSN1 PDS5B H2BC17 SMC1A VPS4A SMC3 H2BC12 PDS5A H2BC13 WAPL H2BC14 H2AJ MAU2 RCC2 STAG1 H2BC15 NIPBL NDC80 ZWINT STAG2 H2BC11 RAD21 KIF20A KIF18A RPS27 AHCTF1 H3C15 PPP2R5E NUF2 H2BC9 SPDL1 NDEL1 H2AZ2 H4C9 NUDC H2BC8 PPP2R5B H2BC5 PPP2R5A H2BC3 PPP2R5D PPP2R5C H3-4 DYNLL1 H2BC1 RANGAP1 H2AC20 CKAP5 DYNLL2 KIF2A MAPK1 INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 LPIN1 CENPT LPIN2 DYNC1H1 CENPU LPIN3 NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CCNB1 CDC23 UBE2S CDC26 CDC27 CDC16 CDK1 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PPP2R2A SEM1 CLIP1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 95%9032845 Activated NTRK2 signals through CDK5 TIAM1 RAC1 NTRK2 BDNF CDK5 CDK5R1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.4 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus NEURL1B UBA52 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 PSEN1 UBB NOTCH2NLA UBC NOTCH2NLC NOTCH2NLB RPS27A MDK JAG2 JAG1 DLL1 NOTCH2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 95%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells TGFA AREG EGF MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint NUP107 NUP160 NUP85 NUP43 RANBP2 SEC13 NUP133 NUP37 ERCC6L ZWILCH BUB1B CDC20 PPP1CC PPP2R1B PPP2R1A KNTC1 KNL1 SGO1 DYNC1LI1 SGO2 DYNC1LI2 ZW10 MAD1L1 CDCA8 PMF1 SKA1 SKA2 DSN1 RCC2 NDC80 ZWINT KIF18A RPS27 AHCTF1 PPP2R5E NUF2 SPDL1 NDEL1 NUDC PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 RANGAP1 CKAP5 DYNLL2 KIF2A INCENP BIRC5 KIF2C KIF2B MAPRE1 ITGB3BP PAFAH1B1 DYNC1I2 MIS12 CENPA AURKB NSL1 CENPC PPP2CA PPP2CB BUB3 BUB1 DYNC1I1 CLASP1 CLASP2 CENPT DYNC1H1 CENPU NDE1 CENPE CENPF CENPH CENPI TAOK1 CENPK CENPL XPO1 CENPM CENPN B9D2 CENPO CENPP CENPQ SPC24 SPC25 MAD2L1 ANAPC15 CENPS ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CLIP1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE PLA2G2D PLA2G2E MBOAT1 PLA2G3 MBOAT2 PLA2G5 PLA2R1 PLA2G6 PLA2G10 ABHD4 PLAAT1 PLAAT3 PLA2G2A PLAAT2 PLAAT5 PLAAT4 PLA2G4A PNPLA8 PLA2G4F PLA2G12A PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLA2G1B LPCAT4 LPCAT3 PLBD1 PLA2G2F REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A11 SLC6A13 SLC6A12 SLC6A1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME%R-HSA-5619043.3 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance CLTC HDLBP PCSK9 CLTA AP2A1 VLDLR LIPA AP2A2 LIPC LDLRAP1 UBA52 AP2M1 CUBN AMN APOA1 LSR NPC1 SOAT1 SOAT2 APOE NPC2 CES3 UBB MYLIP NR1H2 APOC4 UBC AP2S1 NR1H3 LDLR RPS27A APOBR AP2B1 APOC1 NCEH1 APOB BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 95%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADHA ECHS1 ACADM HADH SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins STRN WDR48 FIP1L1 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 95%1268020 Mitochondrial protein import TOMM20 GFER OTC TOMM7 TOMM5 TOMM6 SAMM50 TOMM22 MTX1 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX19 COX17 ATP5MC1 TIMM50 PITRM1 GRPEL1 GRPEL2 LDHD CYC1 DNAJC19 COA4 CHCHD10 TIMM44 CS VDAC1 TIMM10B COQ2 HSPD1 ACO2 HSCB TIMM17A TIMM17B COA6 SLC25A4 SLC25A6 TIMM23 TIMM22 HSPA9 TIMM21 TOMM70 SLC25A12 PMPCB FXN PMPCA SLC25A13 NDUFB8 TOMM40 TAFAZZIN TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 TP53 ATM PSMD3 PSMD1 DISEASES OF IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%5260271 Diseases of Immune System CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 95%9612973 Autophagy TOMM20 TOMM7 MFN1 TOMM5 MFN2 TOMM6 HSF1 IFT88 VCP TBK1 USP30 UVRAG UBE2L3 MAP1LC3B HSP90AA1 BECN1 HDAC6 GABARAPL3 ATG3 GABARAPL1 ATG9B ATG10 ATG13 ATG101 ATG16L2 ATG16L1 WDR45 MAP1LC3C RB1CC1 WIPI2 ATG4C ATG4B ATG4A GABARAPL2 ATG4D DYNC1LI1 WDR45B AMBRA1 DYNC1LI2 CHMP4C CHMP4B VPS28 CHMP4A TSG101 VPS37C VPS37D VPS37A VPS37B GABARAP CHMP2B CHMP2A MVB12B EEF1A1 MVB12A UBAP1 UBE2N PIK3C3 MAP1LC3A CETN1 FUNDC1 PARK7 MTMR3 ATG5 ATG9A RNASE1 CHMP3 ATG12 GFAP ULK1 CHMP6 CHMP7 PIK3R4 DYNLL1 ATG14 ARL13B HSP90AB1 DYNLL2 HBB TOMM22 DYNC1I2 PRKAA1 ATG7 PRKAA2 MTMR14 PRKAG1 PRKAG2 PRKAG3 SQSTM1 RPTOR MLST8 PLIN3 DYNC1I1 SLC38A9 PRKAB2 DYNC1H1 TSC2 TSC1 PRKAB1 MTOR UBE2D2 UBE2D3 RRAGA RRAGC RHEB RRAGB RRAGD EPAS1 PINK1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 VDAC3 VDAC2 VDAC1 CFTR UBA52 PLIN2 UBB TOMM70 UBC PEX5 RPS27A NBR1 UBE2V1 OPTN HSPA8 PRKN CSNK2A1 TOMM40 CSNK2A2 PCNT CSNK2B LAMP2 ATM MTERF3 WIPI1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVP AVPR1A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 95%499943 Interconversion of nucleotide di- and triphosphates NUDT13 AK1 RRM2 AK2 AK4 NME1 AK5 AK6 AK7 AK8 DCTPP1 AK9 GLRX NME2 NME3 NME4 DCTD TXNRD1 CMPK1 TYMS CTPS2 CTPS1 RRM1 RRM2B DTYMK TXN GUK1 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME DATABASE ID RELEASE 95%446199 Synthesis of dolichyl-phosphate SRD5A3 MVD DOLK DOLPP1 DHDDS NUS1 DHRSX DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 95%4549380 Defective ALG1 causes CDG-1k ALG1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants PIK3CB HRAS SOS1 STAT3 PIK3R2 PIK3R1 NRAS PIK3CA STAT1 PDGFRA BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ALOX15 ALOX5 LTA4H ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling DUSP6 DUSP7 KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G DUSP8 DUSP9 IQGAP1 MRAS FAM114A2 QKI NF1 KIAA1549 DUSP10 ESRP1 TRIM24 FXR1 FN1 PHB1 AGTRAP MAP3K11 ARAF AP3B1 PEBP1 SHOC2 CSK AGGF1 JAK2 TENT4A DUSP16 MARK3 SPRED3 FGB SPRED2 BRAP SPRED1 FGA VWF KSR1 KRAS PPP1CB FGG PPP1CC BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 95%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes ACSS3 CXXC1 AGPAT2 ABL1 KANSL1 KANSL2 KANSL3 THRSP GPAM ANGPTL4 LPL CDK8 CDK5 TADA3 OGT DPY30 WDR5 PSIP1 RB1 CIDEC RBBP5 KMT2D H2AX H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L KMT2B H2BC21 EP300 H3-3B H3C8 MED1 H2AC8 MED30 H2AC6 H2AC7 MED31 H2BC17 ACSL1 H2BC12 ELOVL5 H2BC13 MED4 H2BC14 MED6 H2AJ MED7 H2BC15 H2BC11 CEBPA KMT2A H3C15 RXRA SCD H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 SETD1B SETD1A HDAC3 GPS2 LIPE TBL1X DGAT2 NCOA1 PHF20 FABP4 ASH2L NCOR2 NCOR1 TBL1XR1 LPIN1 MGLL PLIN1 PDK4 KAT8 HCFC2 WDR82 PAXIP1 PEX11A AJUBA KAT14 ZZZ3 HCFC1 TADA2A SGF29 PPARGC1A CD36 NCOA2 PPARGC1B NCOA6 NCOA3 CCNC PHF20L1 NR5A2 PLIN4 PLIN2 PNPLA2 PHLDA1 ADIPOQ MED16 BOD1L1 CREBBP MED17 MBIP MED12 TASP1 MED14 DR1 MED13 BOD1 KAT2B KAT2A YEATS2 MED10 MEN1 AKAP8L PAGR1 MED27 KDM6A SIRT1 MED23 MCRS1 MED24 MED20 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CITED1 CITED2 CITED4 CGA YY1 HSPD1 ERBB2 VEGFA CDKN1A EGFR DEK NPM1 APOE ATAD2 CREBBP YEATS4 NOP2 TFAP2A TFAP2B ESR1 EP300 WWOX MYC TFAP2C UBE2I TFAP2D SUMO1 TFAP2E KCTD1 KCTD15 KDM5B CGB8 TGFA KIT MYBL2 PITX2 CHYLOMICRON ASSEMBLY%REACTOME%R-HSA-8963888.2 Chylomicron assembly APOA1 APOA4 APOB APOE APOC2 APOC3 SAR1B MTTP P4HB APOA2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.2 Defective cofactor function of FVIIIa variant F9 F10 F8 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 95%4420097 VEGFA-VEGFR2 Pathway BAIAP2 ABI2 PIK3R2 PIK3R1 ABI1 NRAS RHOA THEM4 RICTOR ROCK1 ROCK2 PRKACG PRKACA CTNNB1 PRKACB SPHK1 ELMO2 CDC42 MLST8 ITPR1 ITPR2 ITPR3 CYFIP2 ELMO1 MTOR HSPB1 SHC2 NOS3 PRR5 MAPK12 MAPK13 AKT1 CALM1 CYFIP1 NCKAP1 PRKCD DOCK1 NCF1 PRKCA NCF2 KDR CRK NCF4 PTK2B PXN BRK1 HSP90AA1 MAPKAPK2 JUP CTNND1 PLCG1 CTNNA1 SHB CYBB CYBA SH2D2A PIK3CB MAPKAPK3 CDH5 AXL NCK2 NCK1 RASA1 AKT2 MAPK14 PRKCZ MAPK11 PAK1 PAK3 RAC1 HRAS PRKCB WASF3 BCAR1 AHCYL1 FYN VAV3 PDPK1 NCKAP1L WASF1 PAK2 WASF2 PTK2 PIK3CA ITGB3 VAV1 VAV2 CAV1 AKT3 ITGAV TRIB3 MAPKAP1 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair PCNA KDM4B ABL1 MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR CLSPN RNF4 FIGNL1 RNF168 NSD2 FIRRM RTEL1 ABRAXAS1 TP53BP1 H2AX SIRT6 POLD3 H2BC26 POLD4 POLK POLD1 H2BC12L POLE POLD2 H2BC21 RFC1 PARP2 RNF8 LIG3 UBE2V2 CHEK2 H2BC17 H2BC12 XRCC1 H2BC13 H2BC14 POLE4 H2BC15 H2BC11 ERCC4 ERCC1 POLE2 POLE3 UBE2N HERC2 H2BC9 H4C9 H2BC8 H2BC5 XRCC6 H2BC3 XRCC4 H3-4 XRCC5 PARP1 H2BC1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLH RAD52 CDK2 MAPK8 MDC1 KDM4A FEN1 SUMO2 UBE2I SUMO1 PAXIP1 SMARCA5 PIAS4 BRCC3 UBA52 PRKDC BAZ1B BAP1 BLM MRE11 BRCA1 BRCA2 BABAM1 RAD51AP1 BABAM2 WRN BRIP1 KAT5 EXO1 UIMC1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 APBB1 UBC RFC5 EYA1 RMI2 EYA2 RFC3 EYA3 RFC4 RPS27A EYA4 PPP5C RMI1 RFC2 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 UBXN1 RAD51D RAD51 RAD51C RPA3 KPNA2 RAD17 DCLRE1C TP53 CCNA2 RAD1 RIF1 ATM CCNA1 DNA2 POLL NHEJ1 RAD9B RHNO1 POLM TDP2 ATR TDP1 RAD9A POLQ METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.6 Metabolism of cofactors COQ9 DHFR COQ7 COQ6 COQ5 COQ2 COQ4 HSP90AA1 HPDL COQ3 PDSS2 PDSS1 COQ8B COQ8A ACO1 GCHFR GCH1 SPR PTS PRKG2 NOS3 STARD7 AKT1 CALM1 IDH1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells EOMES SOX17 CXCR4 BMP4 PDPN PRDM1 TET2 TFAP2C POU5F1 NANOG NANOS3 CBFA2T2 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism CPOX SLCO1B1 SLCO1B3 ABCG2 UROD GSTA1 UROS ALAS2 BLVRB ABCC2 BLVRA COX15 ALAD FABP1 FECH COX10 PPOX ALAS1 HMBS ABCC1 ALB UGT1A4 HMOX1 HMOX2 UGT1A1 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME%R-HSA-9918487.1 Dengue Virus Genome Translation and Replication HDLBP KPNA7 NACA FASN KPNA4 KPNA5 KPNA3 BTF3 RPN2 BAG2 TUSC3 RPN1 MAGT1 APOA1 HSPA5 SPCS3 VCP SPCS2 DNAJA2 PRKG2 SPCS1 OST4 SEC11A RTN3 SEC11C HSPA1B DDOST VIM TMEM258 DAD1 OSTC CANX CALR ACOT2 YBX1 STT3A EIF4E STT3B SCAP UBE2I SUMO1 P4HB HYOU1 XPO1 MAP1LC3B KPNA1 XRN1 IPO7 DNAJB11 PABPC1 P4HA1 UBA52 P4HA2 P4HA3 NPLOC4 DNAJC10 DPM1 NMT1 DPM2 DPM3 PDIA3 KPNB1 UFD1 RRBP1 UBB EIF4E3 UBC DNAJC3 RPS27A EIF4G3 EIF4G2 SUN2 HSPA8 EIF4A2 EIF4A1 HSPA1A KPNA2 EIF4G1 EIF4A3 ATL2 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 95%190372 FGFR3c ligand binding and activation FGF18 FGF1 FGF2 FGF23 FGF4 FGF9 FGF20 GALNT3 FGF16 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism MAPDA NT5C2 ADH1A PCK1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling CAPZA1 PRKCSH AGER LGALS3 S100A12 MAPK1 APP S100B SAA1 HMGB1 CAPZA2 MAPK3 DDOST ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.4 Essential pentosuria DCXR NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair PCNA YY1 RUVBL1 USP7 ERCC6 GPS1 INO80C INO80B INO80E INO80D COPS4 COPS2 ISY1 ACTR5 RAD23A ACTR8 RAD23B UVSSA TFPT LIG1 POLD3 POLD4 POLK POLD1 POLE POLD2 PIAS3 RFC1 PARP2 USP45 LIG3 RNF111 CHD1L DDB1 UBE2V2 XPA COPS7B XPC COPS7A XRCC1 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 ERCC1 POLE2 POLE3 UBE2N ERCC5 COPS8 AQR PARP1 ZNF830 SUMO3 SUMO2 PIAS1 UBE2I SUMO1 PRPF19 RBX1 NFRKB CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G CETN2 POLR2H UBA52 POLR2I INO80 POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 XAB2 GTF2H4 GTF2H5 CDK7 ELL ERCC3 ERCC2 MNAT1 ACTB UBB ACTL6A UBC RFC5 RFC3 RFC4 DDB2 RPS27A TCEA1 RFC2 RPA1 ERCC8 RPA2 RPA3 PPIE MCRS1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription IRF1 JUN YAP1 H2BC9 H2AZ2 H4C9 H2BC8 RELA H2BC5 H2BC3 STAT3 TCF7L2 H2BC1 NFKB1 TCF7L1 H2AC20 LEF1 TCF7 CTNNB1 STAT1 ATF3 JUND ASH2L MYCN FOSB MYC TEAD1 TEAD2 TEAD3 TEAD4 SUZ12 DPY30 EPAS1 WDR5 HIF1A EED RBBP4 NFKB2 EZH2 RBBP5 RBBP7 H2AX CREBBP H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 NFE2L2 EP300 H3-3B H3C8 H2AC8 WWTR1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 FOS H2BC11 KMT2A H3C15 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 95%71240 Tryptophan catabolism AADAT SLC3A2 ACMSD AFMID SLC36A4 HAAO KYAT1 TDO2 IDO2 IDO1 SLC7A5 KYAT3 KMO KYNU PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 95%6791465 Pentose phosphate pathway disease TALDO1 RPIA SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW DPM2 PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 AGRN GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 HSPG2 EXT1 SDC1 SDC4 SDC2 SDC3 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions ITGB4 DDR2 DRP2 ITGB5 DMD ITGA6 TNC PDGFB TGFB1 ACTN1 ITGA2 HSPG2 UTRN SNTG2 SDC4 SDC2 SDC3 TRAPPC4 SGCE SGCD AGRN SGCA NTN4 SGCB SGCG SNTA1 SGCZ NRXN1 SNTB1 CASK SNTB2 SDC1 PRKCA LAMA5 LAMA2 THBS1 LAMB3 LAMC3 LAMB2 LAMA1 LAMA4 LAMA3 LAMB1 LAMC2 LAMC1 VTN DAG1 FGF2 PDGFA TTR DTNA DTNB SSPN DDR1 ITGB3 ITGB1 ITGAV DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 95%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.2 FOXO-mediated transcription of cell cycle genes KLF4 FOXG1 SMAD2 SMAD4 SMAD3 PCBP4 FOXO1 CDKN1A CDKN1B CCNG2 MSTN FOXO3 FOXO4 GADD45A CAV1 RBL2 BTG1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ZNF420 CREBBP BBC3 BNIP3L PRELID3A PMAIP1 PRELID1 STEAP3 AIFM2 TP53AIP1 TP53INP1 BAX BID TP63 TP73 PPP1R13B TP53 ATM TRIAP1 TP53BP2 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA PHLDA1 AURKA REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome DDX5 ZCRB1 VHL RB1 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism PLPP2 ACER2 PLPP1 ACER1 ALDH3B2 SGPP2 ACER3 SGPP1 ALDH3B1 SGPL1 PLPP3 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 95%3781865 Diseases of glycosylation SLC26A2 SRD5A3 GALT B3GALT6 B4GALT7 NCAN HEXB HEXA BGN DCN BCAN VCAN GLB1 CSPG5 CSPG4 GALM ADAMTS13 POMT2 POMT1 POMGNT1 B4GAT1 DAG1 PGM1 LARGE1 GALK1 CHSY1 GALE PRELP CHST6 OMD KERA NOTCH2 OGN NOTCH3 NOTCH1 NOTCH4 CHST3 MUC13 CHST14 HSPG2 MGAT2 PAPSS2 MOGS SDC4 ACAN SDC2 SDC3 LUM B3GAT3 AGRN FMOD B4GALT1 MAN1B1 GPC1 GPC3 GPC2 GALNT12 GPC5 DPAGT1 SEMA5A GPC4 SPON2 SEMA5B GPC6 SPON1 THSD7B MPI ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 EXT1 ADAMTS3 SDC1 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ALG8 ADAMTSL2 MUC12 THSD7A ALG9 MUC15 ALG6 ADAMTS8 ADAMTS9 ADAMTS6 ALG14 ADAMTS7 ALG2 SBSPON THBS1 MUCL1 ALG3 ALG13 MUC3A ALG12 MUC5AC ALG11 MUC3B ALG1 ADAMTS20 B3GLCT CFP DHDDS THBS2 DPM1 ADAMTS12 DPM2 THSD1 DPM3 THSD4 ADAMTS10 RFT1 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 GNE ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 NEU1 SSPOP MUC5B MUC20 MUC21 LFNG ST3GAL3 MPDU1 CTSA NUS1 PMM2 GFPT1 DOLK BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 95%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV BCKDHA BCKDHB DBT DLD ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME DATABASE ID RELEASE 95%9956593 Enterobacterial factors antagonize host defense UBC GBP1 RPS27A UBA52 GBP2 GBP6 UBE2D2 GBP4 CASP4 CALM3 CALM2 CALM1 UBB DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702506 Drug resistance of FLT3 mutants FLT3 HCN CHANNELS%REACTOME%R-HSA-1296061.5 HCN channels HCN4 HCN3 HCN2 HCN1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 NEURL1B GZMB UBA52 HES5 APH1A DLL4 MIB2 PSENEN NCSTN MIB1 APH1B PSEN2 NEURL1 ADAM10 CNTN1 MAMLD1 PSEN1 UBB RBPJ NOTCH2NLA UBC NOTCH2NLC MAML2 NOTCH2NLB MAML1 FCER2 RPS27A MDK EP300 JAG2 JAG1 DLL1 MAML3 NOTCH2 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 95%3247509 Chromatin modifying enzymes RELA SAP30L ATF7IP KANSL1 KANSL2 KANSL3 ARID4A ARID2 KAT7 SUPT20H ATXN7L3 PADI3 PADI4 PADI1 PADI6 SETDB2 BRMS1 SUV39H2 SETD2 SETD3 SETD6 SETD7 KDM4C ING4 ING3 PAX3 PHF21A ASH1L SUPT3H TAF6L DOT1L NSD3 NSD1 BRD8 ELP1 ELP2 ELP3 DPY30 ELP4 CHD4 ELP5 ELP6 JADE1 JADE3 JADE2 KMT5B KMT5C SUPT7L RCOR1 MORF4L1 KAT6B MORF4L2 HAT1 ENY2 EED TAF5L SMYD3 DMAP1 SAP18 MRGBP TAF9 TADA1 BRWD1 VPS72 HMG20B MSL2 MTA2 MSL3 MSL1 TAF12 MTA1 PRDM16 REST MTA3 CARM1 RPS2 HDAC1 SETD1B SETD1A CCND1 ATF2 EHMT2 EHMT1 PHF20 ASH2L ING5 TRRAP H2AC17 BRD1 H2AC12 MEAF6 HCFC1 TADA2B H2AC25 H2AC21 EZH2 ACTB ACTL6A YEATS4 KAT2B KAT2A ACTL6B KAT6A MCRS1 PHF2 KDM5C KDM3B KDM5D PHF8 UTY KDM4B KDM2A KDM4D RUVBL1 KDM2B ARID5B JMJD6 RIOX2 KDM7A H2AC1 PADI2 MBD3 EP400 ATXN7 GATAD2B GATAD2A SUDS3 TADA3 OGT WDR5 KMT5A NSD2 RUVBL2 H2BC18 SMARCD1 SMARCD2 SMARCD3 HDAC8 RBBP4 RBBP5 RBBP7 CDK4 SMARCE1 H2AX PRDM9 KMT2D H2AB1 H2AC19 H2BC26 H2AC14 KMT2C KMT2B USP22 H2BC21 TAF10 HDAC10 EP300 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 SMYD2 H2BC12 KDM5A H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A KDM6B H3C15 H2BC9 BRPF1 H2AZ2 H4C9 BRPF3 H2BC8 PRMT6 H2BC5 PRMT5 H2BC3 H2BC1 NFKB1 PRMT1 H2AC20 KDM3A HDAC3 KDM1A KDM1B GPS2 PRMT7 PRMT3 TBL1X WDR77 NCOA1 COPRS KDM4A NCOR2 NCOR1 CHD3 TBL1XR1 SAP130 HDAC2 KAT8 KDM5B SUZ12 KAT14 SETDB1 ZZZ3 ARID1A TADA2A ARID1B SUV39H1 MECOM SGF29 NCOA2 SMARCB1 AEBP2 EPC1 NFKB2 SMARCC1 JAK2 SMARCC2 ARID4B KAT5 SAP30 CLOCK CREBBP MBIP DR1 YEATS2 SMARCA2 SMARCA4 KDM6A DNMT3A PBRM1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 95%5687583 Defective SLC34A2 causes PALM SLC34A2 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 95%9927020 Heme assimilation HBA2 HBB RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6793080.7 rRNA modification in the mitochondrion MRM3 RCC1L RPUSD4 NGRN RPUSD3 TRUB2 MTERF3 NSUN4 FASTKD2 MTERF4 TFB1M MRM1 MRM2 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 95%5668541 TNFR2 non-canonical NF-kB pathway UBA3 UBE2M CHUK TNFRSF18 RELB MAP3K14 PSMD8 PSMD6 TNFRSF6B PSMD7 EDA TNFRSF13B PSMD2 TNFRSF11B EDA2R PSMD3 TNFSF13B TNFRSF1A PSMD1 TNFRSF17 TNFRSF8 TNFSF11 TNFRSF4 EDARADD TNFSF18 TNFSF14 PSMA5 TNFSF15 PSMA6 CD70 TRAF2 PSMA3 TNFRSF9 EDAR PSMA4 PSMA1 TNFSF6 TNFSF4 PSMA2 LTA TRAF3 CD27 TNFRSF12A TNFSF9 TNFRSF25 UBA52 BIRC2 TNFSF12 TNFRSF13C TNFSF8 BIRC3 PSMD12 TNFRSF11A PSMD11 CD40LG LTBR LTB PSMD14 BTRC PSMD13 PSMA7 NFKB2 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 TNFRSF1B RPS27A TNF FBXW11 TNFSF13 TNFRSF14 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CUL1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 APOD SLC27A4 LCN12 LCN1 SLC27A6 LCN9 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress STOML2 OMA1 PHB2 YME1L1 EIF2AK1 DELE1 EIF2S2 EIF2S1 EIF2S3 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway IFNA2 MED19 IFNA8 MED18 MED11 ARIH1 IFNA13 IFNA14 FURIN IFNA16 IFNA17 MED9 MED29 MED28 MED22 OAS2 MED21 MAP1B IFNA10 CX3CR1 IFNA21 CDK19 IFNB1 EIF2AK2 SPCS3 ISG15 SPCS2 MED13L SPCS1 CD209 SEC11A SEC11C CDK8 IRF3 IFNAR1 MAVS RIGI TLR2 HSP90AA1 EGFR CD14 RAB5B RAB5C BECN1 TLR7 RAB5A KPNB1 PPP1CC TLR4 BCAP31 STAT2 EP300 LY96 MED1 MED30 MED31 MED8 MED4 MED6 MED7 H2BC15 UBE2L6 HERC5 HSP90AB1 HSPG2 SDC4 SDC2 SDC3 AGRN TLR3 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 TLR6 ELOB XPO1 ELOC RBX1 TRIM25 SDC1 CCNC UBA52 PPP1CA IFIH1 JAK1 PPP1CB UBB MED16 MED15 CREBBP MED17 UBC MED12 TYK2 MED14 MED13 RPS27A NCL MED10 HSPA8 CUL5 CSNK2A1 CSNK2A2 CSNK2B MED27 MED26 MED23 IGF1R MED25 IFNA5 MED24 IFNA4 MED20 IFNA7 IFNA6 CLEC4M DEFECTIVE AMN CAUSES MGA1%REACTOME DATABASE ID RELEASE 95%3359462 Defective AMN causes MGA1 CUBN CBLIF AMN LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME DATABASE ID RELEASE 95%9664433 Leishmania parasite growth and survival GNG13 GNB2 GNB1 ADCY9 GNB4 FURIN GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG IGHV3-23 PRKACA PRKACB IGLV IGLV2-8 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 GNAZ IGKV1D-33 CD163 RHBDF2 ADORA2B GNG3 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 GNG2 GGT1 ADAM17 ITPR3 GNG5 IGKV2D-30 GNG4 IGHV4-59 GNG7 IGHV1-69 GNG8 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A FCGR2A PRKAR2A PRKX MYH9 IGHG3 IGHG4 IGHG1 IGHG2 DPEP2 V2-11 DPEP1 V3-4 V3-3 V2-17 PLK2 V3-2 V2-15 V2-19 GNAT3 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 GNAI3 GNAI1 V4-6 V4-2 GNAI2 V4-1 CALM1 LYN IL10 MAPK14 YES1 HCK SYK AHCYL1 FYN GNG10 GNG12 GNG11 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 95%9702509 FLT3 mutants bind TKIs FLT3 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 95%9665250 Resistance of ERBB2 KD mutants to AEE788 ERBIN HSP90AA1 ERBB2 CDC37 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 95%167161 HIV Transcription Initiation CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNG13 CCT6A GNB2 GNAQ GNB1 PDCL GNB4 GNB3 GNB5 GNGT1 CCT2 GNGT2 CCT3 TCP1 CCT6B CCT7 GNA14 GNG3 RGS9 GNA15 RGS6 RGS7 GNG2 GNG5 GNG4 GNG7 CSNK2A1 GNA11 GNG8 CCT8 CSNK2A2 CCT5 CCT4 CSNK2B RGS11 GNG10 GNG12 GNG11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 95%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER PCNA UBA52 UBB LIG1 UBC RFC5 POLD3 POLD4 RFC3 POLD1 POLK RPS27A RFC4 POLD2 POLE RFC2 RFC1 RPA1 LIG3 RPA2 XRCC1 POLE4 RPA3 POLE2 POLE3 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 YAP1 HBEGF STAT5A GFAP SPARC STMN1 APH1A PSENEN NCSTN APH1B PSEN2 PSEN1 APOE ADAP1 CSN2 NCOR1 CXCL12 MXD4 ESR1 WWOX ADAM17 SRC NRG1 S100B TAB2 EREG NRG3 PGR NRG4 NRG2 BTC ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 95%1280218 Adaptive Immune System YAP1 SEL1L RELA ERLIN1 ERLIN2 ITCH KLC1 RNF185 KLC4 KLC3 KLC2 IFI30 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 KIF5B KIF5A HLA-DOA HLA-DOB LAG3 CTSO CTSF CTSE HLA-DMA HLA-DMB RILP PRR5 DPY30 YWHAG EED RNF111 UBE2V2 RAC1 PRKCB PRKCQ COPS5 UBE2N VAV1 MAPKAP1 NEDD4L CD81 V2-11 DCTN6 V3-4 DCTN5 V3-3 V2-17 DCTN1 DCTN4 V3-2 V2-15 V2-19 NFATC2 V1-11 V1-16 V1-13 CAPZA3 CAPZA2 ACTR10 SOCS1 CD19 IKBKB V2-8 V1-20 MYD88 ASH2L V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TEAD1 TEAD2 UBE2D2 TEAD3 UBE2D3 TEAD4 ELOB V4-6 ELOC V4-2 RBX1 V4-1 EPAS1 CUL2 HIF1A VHL ICOSLG WWP1 FBXO4 FBXO6 FBXW4 FBXW5 PPL FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 FBXW2 CSNK2B CTSB FBXL3 FBXL5 BTNL9 BTNL8 BTN2A2 BTN3A1 BTN2A1 BTN1A1 BTN3A3 BTN3A2 BTNL2 XDH SIGLEC9 SIGLEC5 WDR5 SEC13 RNF34 RBBP4 RBBP5 PTPRC RBBP7 ITGB2 CDC20 PPP2R1B PPP2R1A DYNC1LI1 DYNC1LI2 KIF18A ITGB1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C DYNLL1 DYNLL2 PTPRJ KIF2A ACTR1B CTSH CD33 EVL CTSC KIF2C KIF2B CHUK DYNC1I2 CDC42 PPP2CA KCTD6 PPP2CB LILRA3 DYNC1I1 DYNC1H1 LAIR1 SMURF1 LILRB2 CENPE LILRB3 CD300A OSCAR TYROBP SELL NFKB2 CSK FGB FGA CD274 FGG SYK LCK FYN SKP1 CUL1 CLTC CLTA AP2A1 AP2A2 AP2M1 RAP1GAP2 RASGRP2 MIB2 RASGRP1 RAP1GAP RAP1B RAP1A PRKACG RAF1 IGHV3-23 PRKACA PRKACB RAPGEF3 IGLV SIPA1 RAPGEF4 IGLV2-8 IGKV1-16 SAR1B IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 AP2S1 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 AP2B1 IGKV2D-30 IGHV4-59 IGHV1-69 CD79B IGLV2-11 CD79A IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 TRPC1 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 VASP IGHM SH3KBP1 IGHV4-34 IGHV1-2 ITK IGHV1-46 TRAC CD3G IGHV4-39 CD3E IGHV CD3D IGKV2-29 TRBV12-3 IGKV2-28 IGLC3 TRAV29DV5 TRBV7-9 BLNK GRAP2 TRBC1 IGLC1 IGLC2 HLA-DQA2 BTRC HLA-DQA1 HLA-DPA1 HLA-DRB5 IGKV3D-20 IGHD TRAV19 HLA-DRB4 FYB1 IGKV2-30 ENAH IGLV3-19 HLA-DPB1 IGHV2-70 TRAV8-4 IGHV2-5 HLA-DRA IGLV3-1 LCP2 IGHV3-48 HLA-DRB3 IGLV3-25 HLA-DRB1 IGLV3-27 IGKC HLA-DQB2 IGKV1-39 LAT IGLV3-21 CD101 IGKV1-33 HLA-DQB1 FCGR3A BRD4 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 PDCD1 PPP3CA PPP3CB LRR1 CCNF UBE2L6 CBLB HERC5 PPP3R1 DCAF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 FBXO7 HERC6 FBXO9 NFATC1 HLA-H WSB1 FBXO2 HLA-B HLA-C ATG14 HLA-F HLA-G HLA-E RNF126 CDC34 HECW2 PSME1 RBCK1 CBLL2 TRIM11 ANAPC13 UBE2J2 UBE2J1 RNF213 DNM2 RNF217 PRKAA1 ATG7 PRKAA2 SEC31A HACE1 PRKAG1 SIAH1 LNPEP PRKAG2 PRKAG3 MEX3C UBAC1 FBXL8 JUND CD207 CALR FBXL4 MLST8 DZIP3 RNF220 FOSB DET1 PRKAB2 LRSAM1 CTSS MRC2 TRIM9 MRC1 PRKAB1 ARIH2 LRRC41 MTOR VAMP8 FKBP1A RNF144B GAN TLR6 RNF138 RNF130 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 NCF1 KBTBD6 KLHL5 NCF2 RLIM NCF4 TRIP12 SNAP23 KBTBD7 KBTBD8 SPSB4 UBE3C UBE2D4 UBE3D FBXO27 LTN1 ACTR1A RNF19B UBE3A UBE3B FBXO21 NEK2 UBE2Z FBXO22 NFATC3 NPEPPS RNF19A PDIA3 FBXW12 AREL1 FBXW8 S100A1 UBE2E3 CYBB FBXO17 CYBA TAP2 FBXO15 UBE2E2 TAP1 UBE4A LMO7 FBXO10 FBXO11 KLHL41 VAMP3 KCTD7 TRAIP RAB7A RNF41 KLHL42 UBE2V1 DCTN2 CUL7 CUL5 UBA7 UBA6 DCTN3 UBA5 UBR4 PAK1 KLHL11 UBR2 RACGAP1 UBR1 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 PAK2 UBE2F UBE2H KLHL25 UBE2B ZBTB16 GLMN KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBOX5 UBE2U RNF182 UBA3 UBE2O TPP2 UBA1 BLMH UBE2K UBE2M TRIM71 FCGR1BP RNF14 KBTBD13 SEC61A2 UFL1 SEC61A1 UBE2Q1 UBE2Q2 TRIM69 UNKL DTX3L PJA2 TIRAP PJA1 TAPBP TRAF7 UBE2R2 SEC22B THOP1 TRIM50 SEC23A MGRN1 CARD11 MALT1 ASB13 ASB14 ASB11 RNF6 ASB12 MAP3K14 RNF7 ASB17 RNF4 ASB18 ASB15 PSMB10 ASB16 FBXL20 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 ASB10 FCGR1A SEC24B TRIM41 SEC24A ERAP2 RNF25 FBXL19 ERAP1 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 ASB7 TRIM36 TRIM37 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 PAG1 WAS KIF23 PAK3 COLEC12 KIF20A ITGAV ITGB5 PDCD1LG2 B3GNT3 SPOP SUZ12 DAPP1 RASGRP3 REL NFKBIE CD22 PIK3AP1 GSK3B CD36 KLRK1 NCR2 BCL10 KIR2DS2 CD300LB TREM1 CD300E MAP3K8 KLRD1 CREBBP NFE2L2 BTLA PTPN6 TNFRSF14 TAB2 FOS NFKBIB AKT3 JUN PTPN22 CD209 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 UBE2L3 CD14 TLR4 LY96 HMGB1 IRF1 RPN2 TUSC3 RPN1 MAGT1 FBXL18 FBXL7 DNM1 OST4 LGMN DDOST TMEM258 DAD1 OSTC CANX STT3A STT3B KEAP1 DNM3 RNF123 LYN INPP5D PIK3CG PIK3R6 PIK3R5 SIAH2 BTK ARF1 CD40LG JAK1 TRIM4 IKBKG RIPK2 OSBPL1A PIK3CD PRKN CAPZA1 PSME2 PPIA AHCYL1 MAP3K7 VCP CXADR SMURF2 NFKBIA PTEN CD74 JAML CD99 TRAF6 BECN1 PIK3CB CAPZB NCK1 AKT2 CTSD HRAS PDPK1 PIK3CA PIK3R3 PIK3C3 TRIB3 SOS1 SH3RF1 PIK3R4 PIK3R2 PIK3R1 NRAS THEM4 PTPN11 ZAP70 CALM1 ANAPC7 UBE2C UBE2E1 CD86 UBE2D1 CD80 ANAPC10 ANAPC11 CDC23 TRAT1 UBE2S CDC26 CDC27 CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 FBXW11 SEM1 KIF5C KIFAP3 HSPA5 KIF3B KIF3C KIF4B KIF4A TLR1 KIF11 S100A9 S100A8 KIF15 TLR2 KIF22 STX4 CD4 KIF26A TCF7L2 TCF7L1 LEF1 TCF7 CCND1 CTNNB1 ATF3 TREM2 TNRC6C MOV10 MYCN AGO3 AGO4 CDH1 MYC AGO1 AGO2 TNRC6A TNRC6B YWHAB PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 AKT1 PSMD1 SPTBN2 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 SEC61G PSMD14 PSMD13 SEC61B EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A ICAM2 ICAM3 ICAM4 ICAM5 ICAM1 CTLA4 ADRM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 C3 RICTOR CUL3 STAT1 KIF3A VCAM1 RBBP6 AP1G1 AP1S2 AP1S1 ITGB7 AP1S3 B2M AP1M2 AP1M1 AP1B1 TRIM32 HLA-A TRIM21 CD8B CD28 NEDD4 MKRN1 PLCG1 FZR1 SKP2 CDK4 BLK H2AX H2AB1 H2AC19 H2BC26 KMT2C H2AC14 H2BC12L H2BC21 EP300 SOCS3 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 KMT2A H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 FBXO32 H2BC1 NFKB1 H2AC20 ITGAL MYLIP TRIM63 ITGA4 IFITM1 CD226 CD1D CD1C CD1B cd21 CD1A SLAMF7 SLAMF6 KIR2DS1 SIGLEC12 SIGLEC11 SH2D1A SIGLEC10 SH2D1B PILRB PILRA TREML1 RAET1E TREML4 TREML2 CD200 NCR1 NCR3 CD200R1 HCST LILRA6 LILRA1 LILRA2 STUB1 LILRA4 LILRA5 NCR3LG1 LAIR2 MICA MICB NPDC1 GLYCAM1 LILRB1 KIR3DL1 KIR3DL2 LILRB4 LILRB5 SIGLEC1 SIGLEC8 SIGLEC7 SIGLEC6 PVR CD96 CD8A KLRF1 CD300C CLEC4G KLRB1 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CD300LD KLRC1 CD300LF CD300LG CD160 CRTAM ULBP1 ULBP3 PIANP KLRG1 SH3GL2 CLEC2B FCGR2B CLEC2D NECTIN2 FBXL21P WWTR1 CTSA YES1 CTSV CTSL CTSK DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ERK1 ERK2 PATHWAY%REACTOME DATABASE ID RELEASE 95%5684996 ERK1 ERK2 pathway PDGFB RASGRP1 RAP1B RAP1A RAF1 PRKG2 IL2 IL3 IL6 FN1 SPTAN1 JAK3 KRAS FNTA RASGRF2 PDGFRA KIT PRKCQ DUSP4 HBEGF DUSP6 DUSP7 LYPLA1 MET GOLGA7 RET PTPRA ZDHHC9 PTPN3 SPTB YWHAB SHC2 SHC3 PSMD8 RALGDS PSMD6 PSMD7 SPTBN4 PSMD2 SPTBN5 RBX1 MAPK12 PSMD3 LAMTOR2 PSMD1 SPTBN2 ARTN LAMTOR3 GFRA1 GFRA3 PSMA5 PSMA6 GFRA2 PSMA3 KBTBD7 PSMA4 GFRA4 PSMA1 PSMA2 RCE1 NRTN UBA52 PSMD12 PSMD11 PSMD14 PSMD13 SPTA1 PSMA7 PSPN PSMB6 PSMB7 JAK1 PSMB4 GDNF PSMB5 UBB PSMB2 PSMB3 CSF2 PTPN7 UBC TYK2 PSMB1 RPS27A WDR83 ADRM1 SYNGAP1 PAQR3 RGL3 PSMC5 RGL2 PSMC6 PEA15 PSMC3 DUSP5 PSMC4 DUSP2 PSMC1 DUSP1 PSMC2 IL17RD RAPGEF2 DAB2IP ARL2 RASAL1 USP17L2 RASAL3 RASGRP4 RASGEF1A RASA3 RASA4 RASA2 ABHD17C ANGPT1 ABHD17B ABHD17A TEK ICMT CUL3 RASGRF1 RGL1 ARRB1 ARRB2 IQGAP1 EGF EGFR FNTB MAP3K11 DUSP16 RASAL2 KLB FLT3 IRS1 PPP1CC PPP2R1B PPP2R1A IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 IL6R RASA1 HRAS FLT3LG FRS2 MAP2K1 MAP2K2 NRG3 PIK3CA ITGB3 NRG4 SPTBN1 ITGA2B NRG2 PPP2R5E NCAM1 SOS1 PPP2R5B PPP2R5A SHC1 PPP2R5D PPP2R5C PIK3R2 PIK3R1 NRAS FGF20 PDE6D MAPK1 FGF23 FGF22 MAPK3 PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CAMK2B CAMK2D SRC ACTN2 CAMK2A NRG1 GRIN2B GRIN2D GRIN1 RASGRP3 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL IL2RA CALM1 IL5RA CSF2RB CAMK2G DUSP8 CSF2RA DUSP9 MRAS IL5 NF1 IL3RA ERBB2 DUSP10 IL2RB CDK1 PHB1 ARAF SHOC2 PEBP1 CSK JAK2 MARK3 SPRED3 FGB BRAP SPRED2 RANBP9 SPRED1 FGA VWF KSR1 IL2RG PPP1CB FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL FRS3 PPP5C AREG BCL2L1 SEM1 FYN PDGFRB TGFA PTK2 HGF EREG BTC EPGN EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 95%5675221 Negative regulation of MAPK pathway DUSP9 DUSP4 PPP2R5B PPP2R5A DUSP6 PPP2R5D DUSP7 PPP2R5C DUSP10 NRAS UBA52 MAPK1 ARAF PEBP1 RAF1 DUSP16 MARK3 BRAP MAPK3 KSR1 BRAF UBB PPP2R1B PPP2R1A PTPN3 PTPN7 PPP2CA PPP2CB UBC RPS27A PPP5C PAQR3 YWHAB HRAS DUSP5 DUSP2 DUSP1 MAPK12 MAP2K1 MAP2K2 PPP2R5E DUSP8 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling IKBKB UBC TRAF2 RPS27A LRRC14 NLRX1 NLRC5 TRAF6 UBA52 USP14 CHUK TP53 CASP8 USP18 IKBKG UBB IKBIP MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.1 mRNA Polyadenylation SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 CPSF4 CPSF7 CPSF1 FUS CPSF3 CPSF2 TRA2B CHERP RBBP6 HNRNPC RBM25 RBMX DDX46 DDX42 YBX1 PTBP1 SNRNP70 RBM5 RBM17 SNRPA1 DNAJC8 SRSF1 CSTF2T U2AF1 U2AF1L4 FIP1L1 PABPN1 PUF60 U2AF2 SNRPB2 SMNDC1 RBM39 HNRNPA3 U2SURP HNRNPA1 TCERG1 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 CLP1 SNRPD3 SRRM2 CDC40 DHX9 CSTF3 CSTF2 HTATSF1 PCBP1 PCBP2 CSTF1 SYMPK RBM10 HNRNPL HNRNPM HNRNPK HNRNPF HNRNPD SUGP1 PPP1R10 PCF11 DHX15 PRPF40A WDR33 HNRNPH1 TUT1 HNRNPH2 SF3B4 POLR2A SF3B5 POLR2B SF3B2 POLR2C SF3B3 POLR2D SF3B6 POLR2E SRRT POLR2F PPP1R8 POLR2G POLR2H SF3B1 UBA52 POLR2I SRSF10 POLR2J SRSF11 POLR2K SRSF12 POLR2L SF3A3 SF3A1 SF3A2 PPP1CA NUDT21 GTF2F1 PHF5A HNRNPA2B1 GTF2F2 PPP1CB PAPOLG UBB PAPOLA NCBP1 UBC NCBP2 RPS27A SNRPN XRN2 SNRPG SRSF2 SRSF3 SNRPE SRSF4 SNRPF SRSF5 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 95%9669926 Nilotinib-resistant KIT mutants KIT CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.6 ChREBP activates metabolic gene expression FASN MLX AGPAT1 ACACA ACLY MLXIPL ACACB EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells CLTC CLTB TIAM1 CLTA AP2A1 EPHB6 EFNB2 AP2A2 EFNB1 LYN EFNB3 EPHB2 EPHB1 EPHB4 AP2M1 EPHB3 APH1A PSENEN EFNA5 NCSTN EFNA4 APH1B PSEN2 CLTCL1 ADAM10 PSEN1 DNM1 EFNA1 EFNA3 EFNA2 MMP9 AP2S1 MMP2 EPHA2 AP2B1 EPHA5 EPHA4 EPHA7 YES1 EPHA6 RAC1 EPHA8 FYN VAV3 EPHA1 EPHA3 EPHA10 VAV2 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 95%9630222 Defective NTHL1 substrate binding NTHL1 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2BC9 H4C9 H2BC8 H2BC5 H2BC3 DYNLL1 H2BC1 NFKB1 H2AC20 DYNLL2 H2AC1 HDAC3 GPS2 TBL1X DYNC1I2 NCOR2 DYNC1I1 NCOR1 TBL1XR1 DYNC1H1 SUZ12 H2AC17 H2AC12 NUP205 POM121 NUP107 NUP188 AAAS NUP214 NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 EED RAE1 NDC1 H2BC18 EGFR RANBP2 SEC13 NUP155 NUP133 TRIM28 NUP210 NUP153 NUP93 H2AC25 NUP50 H2AC21 NUP35 NUP54 RBBP4 EZH2 DAXX NUP37 RBBP7 CBX1 PML H2AC19 H2BC26 DYNC1LI1 H2AC14 DYNC1LI2 H2BC21 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 H2BC11 ELK1 ITGB1 H3C15 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME%R-HSA-3359475.4 Defective MMAA causes MMA, cblA type MMAA MMUT IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 95%9732724 IFNG signaling activates MAPKs IFNG MAPK1 RAF1 JAK2 JAK1 MAPK3 IFNGR1 IFNGR2 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 95%4570571 Defective RFT1 causes CDG-1n RFT1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle SLC1A2 SLC1A3 SNAP25 RAB3A ARL6IP5 STX1A SYT1 SLC1A6 GLS2 SLC1A7 VAMP2 CPLX1 RIMS1 UNC13B GLS SLC38A2 PPFIA1 PPFIA4 PPFIA3 PPFIA2 SLC17A7 SLC1A1 TSPOAP1 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 F9 GGCX LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 95%9632974 LXRs regulate gene expression linked to gluconeogenesis RXRA NR1H3 RXRB NRIP1 PCK1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 95%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD4 ENTPD6 ENTPD7 ENTPD8 ENTPD1 ENTPD5 ENTPD2 ENTPD3 RA BIOSYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 95%5365859 RA biosynthesis pathway CYP26A1 CYP26B1 CYP26C1 ADH1C DHRS4 ADH1A CRABP1 SDR16C5 ADH4 RDH5 RDH11 RDH10 RDH16 RDH14 RDH13 AKR1C3 DHRS3 ALDH1A3 DHRS9 ALDH1A2 ALDH1A1 ALDH8A1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 95%8963676 Intestinal absorption SLC2A5 SLC2A2 SLC5A1 RSC1A1 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 95%187024 NGF-independant TRKA activation NTRK1 NTRK2 ADORA2A ADCYAP1 ADCYAP1R1 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 FCGR1A IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 FCGR2A IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN YES1 HCK SYK FYN ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 95%561048 Organic anion transport by SLC22 transporters SLC22A6 SLC22A8 SLC22A12 SLC22A11 SLC22A7 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling APOF APOB LPA CETP MTTP P4HB SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662360.2 Sensory processing of sound by inner hair cells of the cochlea CACNA1D CABP1 LRRC52 ESPNL EPB41L3 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX TWF1 LHFPL5 TMIE USH1G STRC MYO15A CAPZA2 EPB41L1 KCNMA1 STX1A SLC17A8 KCNMB1 OTOF CASK ATP2B1 SNAP25 RAB3A KCNQ4 DNAJC5 SPTAN1 MSN CAPZB MYO1C CLIC5 RIPOR2 CIB2 CAPZA1 PJVK VAMP2 ESPN EPS8 PCLO BSN PLS1 TPRN TMC1 CACNA2D2 MYO7A MYH9 SYP SYN1 TMC2 CACNB2 MYO3B MYO3A FSCN2 EZR TWF2 PCDH15 SPTBN1 CABP2 USH1C DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 95%5602358 Defects in Toll-like Receptor Cascades CD36 RELA NFKB1 TRAF3 CD14 BTK NFKB2 CHUK TLR7 FGB S100A1 FGA FGG IKBKG TIRAP TLR4 IKBKB IRAK4 MYD88 TLR10 UNC93B1 TLR5 TICAM1 TLR3 LY96 NFKBIA TLR1 S100A9 TLR6 S100A8 TLR2 HMGB1 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation REXO2 FASTKD5 TBRG4 SLIRP PNPT1 FASTKD2 LRPPRC GRSF1 SUPV3L1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 95%6811436 COPI-independent Golgi-to-ER retrograde traffic PLA2G6 DYNLL1 DCTN6 DCTN5 ACTR1A DCTN1 DYNLL2 PAFAH1B3 DCTN4 RAB6A CAPZA3 CAPZA2 PAFAH1B1 DYNC1I2 GALNT1 ACTR10 PLA2G4A CAPZB DYNC1LI1 DYNC1I1 RAB6B GALNT2 DYNC1LI2 DCTN2 DYNC1H1 CAPZA1 DCTN3 RAB3GAP2 PAFAH1B2 RAB3GAP1 BICD1 RAB18 BICD2 AGPAT3 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation YARS1 YARS2 NARS1 NARS2 RARS2 CARS1 CARS2 VARS2 MARS2 DARS2 RARS1 SARS2 LARS1 AIMP1 AIMP2 IARS2 QARS1 WARS1 WARS2 MARS1 DARS1 SARS1 EEF1E1 PARS2 KARS1 EARS2 LARS2 EPRS1 IARS1 PPA2 PPA1 TARS2 TARS1 AARS1 AARS2 HARS1 HARS2 FARSA FARSB FARS2 GARS1 NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.2 Neurofascin interactions CNTNAP1 CNTN1 NRCAM ANK1 SDCBP NFASC DCX TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors CITED2 TFAP2A TFAP2C PITX2 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 CEP41 CEP43 DYNLL1 CKAP5 TUBA1A PRKACA MAPRE1 PAFAH1B1 DYNC1I2 CLASP1 DYNC1H1 NDE1 CCP110 YWHAE TUBB4B TUBB4A YWHAG PLK1 HSP90AA1 CEP57 CETN2 CEP164 ACTR1A PCM1 CNTRL AURKA CDK1 CEP250 NEK2 CEP290 NINL CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E PPP2R1A TUBG1 HAUS2 HAUS1 CPAP AKAP9 CEP63 SFI1 SDCCAG8 DCTN2 SSNA1 HMMR DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 TUBA4A PCNT CEP76 CEP78 PLK4 ODF2 CEP152 NEDD1 ALMS1 TPX2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a PMM2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression JUN YAP1 SEL1L RELA ERLIN1 ERLIN2 RNF185 MIB2 CUL3 VCP STAT1 DERL3 DERL1 DERL2 RNF5 ERLEC1 OS9 DPY30 WDR5 YWHAG EED BTRC RBBP4 RBBP5 RBBP7 CDK4 H2AX H2AB1 H2AC19 BRD4 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 PDCD1 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 COPS5 H2BC11 KMT2A H3C15 IRF1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 STAT3 RPN2 TCF7L2 H2BC1 NFKB1 TUSC3 PDCD1LG2 TCF7L1 B3GNT3 RPN1 H2AC20 SPOP LEF1 TCF7 MAGT1 CCND1 CTNNB1 OST4 PRKAA1 PRKAA2 DDOST PRKAG1 PRKAG2 TMEM258 PRKAG3 DAD1 ATF3 JUND OSTC ASH2L TNRC6C MOV10 MYCN STT3A AGO3 STT3B AGO4 FOSB PRKAB2 MYC AGO1 AGO2 TEAD1 TNRC6A PRKAB1 TNRC6B TEAD2 TEAD3 PSMD8 TEAD4 PSMD6 SUZ12 PSMD7 PSMD2 RBX1 PSMD3 EPAS1 PSMD1 HIF1A GSK3B PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 NEK2 PSMD14 PSMD13 NFKB2 EZH2 PSMA7 PSMB6 PSMB7 JAK1 CD274 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC PSMB1 RPS27A NFE2L2 ADRM1 CSNK2A1 WWTR1 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 FOS CUL1 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 95%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD BCKDHA BCKDHB DBT DLD DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 95%429947 Deadenylation of mRNA PAN3 PAIP1 PABPC1 PARN CNOT4 CNOT6 CNOT7 EIF4E EIF4B CNOT1 CNOT2 CNOT3 TNKS1BP1 CNOT10 CNOT8 CNOT9 CNOT6L CNOT11 EIF4A2 EIF4A1 TUT7 TUT4 EIF4G1 EIF4A3 PAN2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 95%9608290 Defective MUTYH substrate processing METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 95%196849 Metabolism of water-soluble vitamins and cofactors CYB5A SLC23A2 MCCC2 SLC23A1 BTD PC LDLRAP1 PCCA HLCS CUBN MCCC1 AMN PCCB ACACB NUDT12 ABCD4 NADK SLC2A1 CYB5R3 PRSS3 THTPA TCN1 NMRK2 NMRK1 LMBRD1 NAXE NAXD SHMT1 MOCS2 MOCS3 RNLS TPK1 MMAB MOCOS FLAD1 SLC22A13 RFK SLC52A2 SLC52A3 ACP5 SLC52A1 ENPP1 QPRT SHMT2 MTRR SLC25A51 PARP10 PARP6 SLC25A19 PARP4 PARP16 PARP9 PARP14 PARP8 DHFR CD38 GPHN PDZD11 SLC19A3 PANK4 SLC19A2 PANK2 PANK3 NMNAT3 PANK1 NMNAT2 DCAKD NMNAT1 COASY PPCDC SLC25A16 NUDT8 VNN2 NNMT PPCS ENPP2 ENPP3 SLC25A42 AASDHPPT NADSYN1 PNPO AOX1 TCN2 NAMPT CD320 SLC5A6 ACACA CBLIF MMACHC MMADHC FASN BST1 VNN1 GSTO2 SLC46A1 ABCC1 MTR SLC2A3 NAPRT PDXK GSTO1 NADK2 PRSS1 CTRB2 CTRB1 ALDH1L1 DHFR2 MTHFR MTHFS ALDH1L2 MTHFD1 NT5E MTHFD1L SLC5A8 MTHFD2 MTHFD2L LRP2 SLC25A32 FOLR2 SLC19A1 MMAA MMUT EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events UVRAG CHMP3 ISCU MAP1LC3B CHMP6 CHMP7 PIK3R4 FURIN DDX5 RB1 BECN1 HSPG2 VCP TMPRSS2 SDC4 SDC2 SDC3 AGRN ACE2 CHMP4C CHMP4B GPC1 CHMP4A ZCRB1 GPC3 HAVCR1 GPC2 GPC5 GPC4 GPC6 CHMP2B CHMP2A NRP1 SDC1 CTSL VHL PIK3C3 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME%R-HSA-446343.3 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PXN ILK PARVA ITGB1 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 95%389542 NADPH regeneration ACO1 IDH1 FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 95%75094 Formation of the Editosome APOBEC4 A1CF APOBEC3A APOBEC3B APOBEC1 APOBEC3C APOBEC2 APOBEC3H TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes PRDX2 CYCS PRDX1 COX5B COX5A COX6C COX4I1 COX4I2 COX6A1 PRKAA1 COX6A2 PRKAA2 MT-CO1 PRKAG1 G6PD PRKAG2 PRKAG3 RPTOR COX6B2 COX6B1 COXFA4 TNRC6C MLST8 COX7A2 MOV10 RRM2B COX7A1 SLC38A9 HIGD1C AGO3 AGO4 PRKAB2 AGO1 TSC2 AGO2 TSC1 TNRC6A PRKAB1 TNRC6B YWHAB MTOR SCO2 RRAGA DDIT4 RRAGC YWHAE MT-CO2 PTEN SESN3 MT-CO3 RHEB RRAGB SESN2 RRAGD LAMTOR2 AKT1 LAMTOR1 LAMTOR4 YWHAQ LAMTOR3 LAMTOR5 YWHAG GPX2 YWHAH GPI YWHAZ SFN GLS2 GLS TIGAR TP63 TXNRD1 AKT2 COX7A2L COX7B TP53 COX7C TXN COX8A COX8C AKT3 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CCNH PLK1 CCNB1 CDC25C CDK1 CDC25B FZR1 CDC25A CDK2 CDK7 MNAT1 PPP2R1B PKMYT1 PPP2R1A FOXM1 PPP2CA WEE1 HJURP PPP2CB PPP2R2A SGO1 PPME1 BORA OBI1 MIS18BP1 LCMT1 PPP2R3B TICRR XPO1 CCNB2 CCNA2 CCNA1 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140834.4 Extrinsic Pathway of Fibrin Clot Formation F7 F9 F10 F3 TFPI SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers BICRAL BICRA BRD7 BRD9 SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB ARID2 SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B PBRM1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 95%174430 Telomere C-strand synthesis initiation ACD TINF2 TERF1 TERF2 POT1 TERF2IP STN1 TEN1 CTC1 PRIM2 PRIM1 POLA1 POLA2 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels KCNMB3 KCNN2 KCNMA1 KCNMB4 KCNN1 KCNN3 KCNN4 KCNMB1 KCNMB2 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%167246 Tat-mediated elongation of the HIV-1 transcript CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 NELFB NELFCD NELFA NELFE SUPT16H NCBP1 NCBP2 ELOA2 SSRP1 CDK9 TCEA1 ELOB ELOC PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses PTPRS EPB41L3 HOMER3 NTRK3 EPB41 STXBP1 EPB41L5 EPB41L2 HOMER1 HOMER2 PPFIBP1 PPFIBP2 SIPA1L1 DLGAP1 DLGAP3 DLGAP2 DLGAP4 BEGAIN RTN3 LRFN3 APBA3 PTPRD APBA2 LRFN2 LRFN4 EPB41L1 LRFN1 STX1A SHARPIN LRRC4B SYT9 GRIA1 SYT7 LRRTM3 LRRTM4 LRRTM1 LRRTM2 IL1RAPL2 SHANK3 SHANK2 SHANK1 GRIN2C NLGN3 GRIN2B NLGN1 NLGN2 GRIN2D NRXN1 GRIN1 NRXN3 SYT2 DLG1 CASK NRXN2 GRIN2A LIN7A SLITRK2 DLG2 LIN7C SLITRK1 DLG3 SLITRK4 LIN7B SLITRK6 DLG4 PDLIM5 GRIA3 NLGN4Y GRIA4 NLGN4X SYT10 SYT12 APBA1 SYT1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 DBNL IL1RAPL1 PTPRF GRM1 GRM5 SLITRK3 SLITRK5 FLOT1 FLOT2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 95%9702620 quizartinib-resistant FLT3 mutants FLT3 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 95%3323169 Defects in biotin (Btn) metabolism MCCC2 BTD PC ACACA PCCA HLCS MCCC1 PCCB SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 95%4755510 SUMOylation of immune response proteins PIAS4 NFKB2 RELA EIF2AK2 PIAS3 SUMO3 IKBKE NFKBIA UBE2I SUMO1 IKBKG TOPORS UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins HBEGF SNAP25 HSP90AA1 FURIN SYT1 CD9 HSP90AB1 SV2C SV2B SV2A TXNRD1 VAMP1 MAP2K4 STX1A VAMP2 MAP2K7 EEF2 STX1B GUCY2C SYT2 NHERF4 MAP2K1 MAP2K2 CALM1 PDCD6IP DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 95%3781860 Diseases associated with N-glycosylation of proteins ALG9 ALG6 NEU1 ALG14 ALG2 ALG3 B4GALT1 ALG13 ALG12 MAN1B1 ALG11 ALG1 MPDU1 DPAGT1 CTSA RFT1 MGAT2 MOGS GLB1 ALG8 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-HSA-1971475.6 Glycosaminoglycan-protein linkage region biosynthesis CSPG4 HSPG2 SDC4 SDC2 SDC3 B3GAT3 XYLT2 AGRN XYLT1 B3GALT6 B4GALT7 GPC1 FAM20B UXS1 GPC3 GPC2 GPC5 GPC4 NCAN GPC6 PXYLP1 B3GAT2 B3GAT1 BGN DCN BCAN VCAN SDC1 CSPG5 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 95%3065679 SUMO is proteolytically processed SENP5 SUMO3 SENP1 SUMO2 SENP2 SUMO1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C8G C5 C6 C7 CLU C9 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 95%1630316 Glycosaminoglycan metabolism SLC26A2 SLC26A11 SLC26A1 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 CHP1 GNS HAS2 SPAM1 B4GALT6 B4GALT5 B3GALT6 B4GALT7 IDUA NCAN HEXB HEXA BGN GLB1L3 DCN GLB1L2 BCAN VCAN GLB1L HYAL1 GLB1 HYAL3 HYAL4 IDS CSPG5 CSPG4 GUSB ARSB SLC35B3 B4GAT1 SLC35B2 XYLT2 SLC35D2 XYLT1 FAM20B CHPF PXYLP1 CHSY1 CHST11 B3GAT2 CHST12 B3GAT1 B4GALT2 CHSY3 CHST13 B4GALT3 CSGALNACT1 PRELP CHST6 CHST7 OMD CHPF2 CSGALNACT2 KERA B3GNT7 B3GNT4 OGN CHST1 B3GNT2 CHST5 CHST2 B4GALT4 CHST3 B3GNT3 CHST14 HSPG2 PAPSS2 PAPSS1 HS3ST3A1 SDC4 HPSE2 ACAN SDC2 SDC3 LUM HS6ST1 B3GAT3 HS6ST2 SGSH CD44 HS2ST1 HS6ST3 NDST2 AGRN NDST1 FMOD EXTL2 NAGLU B4GALT1 NDST4 GPC1 NDST3 GPC3 GPC2 GPC5 GPC4 EXTL3 GPC6 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 EXT1 SDC1 HPSE DSEL DSE UST CHST15 ABCC5 ST3GAL4 SLC17A5 GALNS ST3GAL6 ST3GAL1 UXS1 HMMR ST3GAL2 ST3GAL3 SLC9A1 CTSL CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 95%2219530 Constitutive Signaling by Aberrant PI3K in Cancer HBEGF RAC2 RHOG NTRK3 PIK3R2 NTF3 PIK3R1 PDGFB FGF20 FGF23 MET FGF22 PTPN11 CD19 FGF16 FGF19 FGF18 FGFR4 FGF10 ESR1 ESR2 SRC NRG1 CD28 PIK3AP1 CD86 CD80 ERBB2 EGF PIK3CG EGFR TRAT1 PIK3R6 PIK3R5 KLB FLT3 IRS1 IRS2 PIK3CB STRN FGF1 FGF2 FGF3 PIK3CD AREG FGF4 FGF6 FGF7 FGF9 PDGFRA RAC1 LCK FYN PDGFRB NTF4 NTRK2 BDNF KIT TGFA GAB1 FLT3LG FRS2 HGF GAB2 EREG NRG3 PIK3CA PIK3R3 NRG4 NRG2 VAV1 BTC EPGN NUCLEOTIDE CATABOLISM%REACTOME DATABASE ID RELEASE 95%8956319 Nucleotide catabolism ENTPD4 ENTPD6 ENTPD7 ENTPD8 NT5C AGXT2 NT5C1A DPYS DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP GDA NT5C2 NUDT5 DNPH1 NT5C1B NUDT16 NUDT15 ADPRM SAMHD1 PNP ITPA NT5E ENTPD1 ENTPD5 ENTPD2 ENTPD3 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME DATABASE ID RELEASE 95%917729 Endosomal Sorting Complex Required For Transport (ESCRT) CHMP3 CHMP6 CHMP7 UBA52 STAM STAM2 HGS VPS36 VPS25 UBB SNF8 UBC RPS27A CHMP4C CHMP4B VPS28 TSG101 CHMP4A VTA1 VPS37C VPS37D VPS37A VPS37B CHMP5 VPS4B VPS4A CHMP2B MVB12B CHMP2A MVB12A UBAP1 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer SOS1 UBC HBEGF RPS27A HSP90AA1 SHC1 AREG EGF CBL PIK3R1 EGFR CDC37 NRAS PLCG1 UBA52 HRAS TGFA GAB1 EREG PIK3CA BTC EPGN UBB SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions FGFR2 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.3 TLR3 deficiency - HSE TLR3 INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 95%8981607 Intracellular oxygen transport CYGB MB NGB TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 95%112307 Transmission across Electrical Synapses GJA10 PANX1 PANX2 GJD2 GJC1 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 95%8853884 Transcriptional Regulation by VENTX ANAPC16 ANAPC7 UBE2C CSF1R VENTX UBE2E1 UBE2D1 RELA ANAPC10 ANAPC11 TCF7L2 CDC23 NFKB1 UBE2S CDC26 CDC27 CDKN2A LEF1 CDC16 ANAPC4 FZR1 ANAPC5 ANAPC1 CCND1 ANAPC2 CTNNB1 CEBPB EHMT2 EHMT1 TNRC6C MOV10 AGO3 AGO4 AGO1 TNRC6A TNRC6B IL6 TP53 ANAPC15 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 95%5654699 SHC-mediated cascade:FGFR2 FGF18 SOS1 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 NRAS FGF20 HRAS FGF23 FGF22 FGF16 COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.6 COPII-mediated vesicle transport TRAPPC6A TRAPPC6B PREB SEC22A SEC22C STX17 LMAN2 TRAPPC10 SEC23IP FOLR1 BET1 CTSZ NSF CTSC COL7A1 SAR1B SEC31A TRAPPC4 TMED10 SEC22B TMED2 SERPINA1 SEC23A GRIA1 CD59 F5 TFG F8 SEC24B SEC24A STX5 USO1 ANKRD28 SEC13 PPP6C PPP6R3 NAPA NAPB SEC24D RAB1A SEC24C RAB1B TRAPPC1 GOLGA2 NAPG CSNK1D GORASP1 AREG TRAPPC2L LMAN1L GOSR2 LMAN1 TBC1D20 LMAN2L SEC31B TRAPPC2 SEC16B TRAPPC3 TGFA SEC16A TRAPPC5 TRAPPC9 YKT6 CNIH1 CNIH2 SCFD1 CNIH3 MCFD2 PPP6R1 APAP ADME%REACTOME DATABASE ID RELEASE 95%9753281 APAP ADME CYP2E1 ABCG2 GSTT1 GSTM1 ABCC2 GGT5 NAT1 GGT7 NAT2 SULT1A1 GGT6 ABCC5 CNDP2 SULT1E1 SULT1A4 ABCC3 GGT3P UGT1A10 GGT1 ABCC1 SULT1C4 ACY1 SULT2A1 GSTP1 ABCC4 SULT1A3 UGT1A6 UGT1A1 UGT2B15 UGT1A9 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 95%449836 Other interleukin signaling CSF3 STX4 TYK2 TXLNA CSF1R SNAP25 STX1A IFNLR1 STXBP2 VAMP2 IL34 IL16 PRTN3 IFNL1 SDC1 JAK1 PTPRZ1 IL32 CD4 STX3 IL10RB CSF3R CSF1 CASP3 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 95%264876 Insulin processing EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 INS KIF5C SLC30A8 PCSK1 SLC30A5 STX1A KIF5B KIF5A MYO5A RAB27A VAMP2 MYRIP P4HB PCSK2 ERO1B EXOC8 CLTRN EXOC7 CPE DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 95%9754119 Drug-mediated inhibition of CDK4 CDK6 activity CCND2 CCND1 CDK6 CDK4 CCND3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ADAM2 SPAM1 ZP1 B4GALT1 ZP3 ADAM21 ZP2 ADAM20 ZP4 OVGP1 ADAM30 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) CYP2E1 PTGR1 ALOX5AP CYP2D6 PTGS2 ALOX15 ALOX12 ALOX5 LTA4H GSTM4 LTC4S HPGD CYP2C9 CYP2C8 CYP3A4 CYP1A2 CYP1A1 EPHX2 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.4 L1CAM interactions RPS6KA1 CLTC CLTA AP2A1 ITGA1 AP2A2 AP2M1 CNTN1 AP2S1 KIF4B AP2B1 KIF4A NCAN RPS6KA6 LAMA1 EGFR LAMB1 LAMC1 SPTAN1 NUMB SDCBP NFASC RAC1 NRP1 MAP2K1 MAP2K2 EZR ITGB3 ITGA2B SPTBN1 ITGB1 L1CAM VAV2 DPYSL2 ITGAV NCAM1 ITGA5 ITGA9 ALCAM SCN11A RDX SCN10A MAPK1 CHL1 ITGA2 LYPLA2 DNM1 DNM2 MAPK3 CNTNAP1 SPTB RPS6KA4 SCN1B SCN1A ANK2 ANK3 SHTN1 DNM3 SPTBN4 DLG1 SPTBN5 SCN3B DLG3 SCN3A SPTBN2 DLG4 CD24 SCN2A SCN2B KCNQ2 KCNQ3 SCN9A EPHB2 SCN8A ITGA10 SPTA1 CNTN6 RANBP9 SCN5A GAP43 DCX SCN4A SCN4B MSN NRP2 SCN7A CNTN2 NRCAM ANK1 SH3GL2 HSPA8 CSNK2A1 CSNK2A2 PAK1 CSNK2B RPS6KA3 RPS6KA5 RPS6KA2 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 95%5578775 Ion homeostasis KCNJ11 ABCC9 SLN ATP1B3 ATP1B2 ATP1B1 ATP2A3 ATP2A2 ATP2A1 PRKACA SLC8A1 SLC8A2 NOS1 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 CAMK2B ITPR3 SRI CAMK2D FXYD4 FXYD3 CAMK2A FXYD2 DMPK FXYD1 FXYD7 FXYD6 ATP2B4 RYR1 ATP2B3 RYR2 ATP2B2 RYR3 ATP2B1 TRPC1 SLC8A3 CLIC2 CALM1 CAMK2G TRDN ASPH ATP1A4 ATP1A3 ATP1A2 TNNI3 ATP1A1 PLN FKBP1B AHCYL1 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 95%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP XRCC1 OGG1 NEIL2 POLB LIG3 NEIL1 DEFECTIVE F9 ACTIVATION%REACTOME DATABASE ID RELEASE 95%9673221 Defective F9 activation GP5 GP9 F9 GP1BA GP1BB F11 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) SS18 SMARCB1 SMARCD1 PHF10 SMARCD2 SMARCD3 BCL11A SMARCC1 SMARCC2 ACTB SMARCE1 ACTL6A BCL11B DPF1 BCL7A DPF2 BCL7C BCL7B DPF3 SMARCA2 ACTL6B SMARCA4 SS18L1 ARID1A ARID1B RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PRKCA GFRA1 SOS1 GFRA3 GFRA2 SHC1 GFRA4 MAPK7 PIK3R2 PIK3R1 NRTN PLCG1 DOK2 DOK4 DOK5 DOK6 RAP1GAP PRKACG PRKACA PSPN PRKACB GDNF RET PTPN11 IRS2 PIK3CB PDLIM7 PIK3CD DOK1 GRB10 SHANK3 SHC3 GAB1 FRS2 GRB7 GAB2 PIK3R3 PIK3CA ARTN G ALPHA (S) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418555 G alpha (s) signalling events GNG13 GNB2 GNB1 ADCY9 GNB4 GNB3 ADCY4 GNB5 ADCY3 ADCY2 ADCY1 ADCY8 GNGT1 ADCY7 ADCY6 ADCY5 GNGT2 PRKACG GIP PRKACA PRKACB ADRB2 PTGIR AVPR2 GNAZ LHB PDE1B ADORA2B GNG3 PDE1A GNG2 RXFP1 GNG5 RXFP2 GNG4 GNG7 PDE11A GNG8 PDE2A ARRB1 ARRB2 PTH1R GPR39 PDE10A PTH2R GPHA2 GNAS NPSR1 CRH NPS GPHB5 LHCGR RLN2 RLN3 P2RY11 GCGR GCG INSL3 GPR84 PTH2 CRHR1 CYSLTR2 RAMP2 CALCA MC1R RAMP3 CALCB PDE3B MC4R CALCR CALCRL GPBAR1 MC3R ADM2 ADM IAPP FSHR GRK5 RAMP1 PTH MC5R PRKAR1B PRKAR2B PRKAR1A PRKAR2A ADRB1 HTR4 ITGB1 GPER1 HTR6 TAAR3P ITGA5 HTR7 CGA HRH2 DRD1 DRD5 PTHLH TAAR8 TSHR TAAR9 TAAR6 GNAT3 TAAR5 TAAR2 FSHB TAAR1 ADRB3 GPR176 GPR15 GPR27 GPR25 GPR20 GPR32 GPR45 GPR150 GPR83 PDE3A PDE8B PTGER4 PDE8A GRK3 GRK6 SRC ADCYAP1 PTGER2 ADCYAP1R1 PTGDR PDE4A PDE4D PDE4C GNAI3 ADORA2A GNAI1 GNAI2 PDE7B PDE7A CRHR2 TSHB POMC GLP1R VIPR1 VIPR2 SCT GIPR GHRHR GLP2R SCTR GHRH VIP AVP GRK2 GNG10 MC2R GNG12 GNG11 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 95%9674555 Signaling by CSF3 (G-CSF) STAT5A STAT5B UBE2D1 SHC1 LYN STAT3 GRB2 UBA52 JAK2 JAK1 STAT1 KRAS SOCS1 UBB PTPN11 CSF3R CSF3 UBC TYK2 RPS27A CUL5 SOCS3 RNF7 HCK SYK UBE2D2 UBE2D3 ELOB ELOC GAB2 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.4 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNQ1 KCNE5 AKAP9 KCNH2 KCNE1 KCNA5 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 FGF1 FGF10 FGF2 FGF23 FGF3 FGF22 FGF4 FGF6 FGF9 PLCG1 FGF20 CO-INHIBITION BY CTLA4%REACTOME DATABASE ID RELEASE 95%389513 Co-inhibition by CTLA4 PPP2CA PPP2CB CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C AKT2 CTLA4 YES1 LCK FYN AKT1 PTPN11 PPP2R1B PPP2R1A PPP2R5E AKT3 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 95%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 95%139853 Elevation of cytosolic Ca2+ levels STIM1 P2RX3 P2RX2 ORAI2 P2RX1 ORAI1 ITPR1 ITPR2 ITPR3 TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 P2RX4 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 95%9839397 TGFBR3 regulates FGF2 signaling FGF2 TGFBR3 GIPC1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression PPP2CA PPP2CB ENSA MASTL PPP2R2D CCNB1 PPP2R1B CDK1 PPP2R1A ARPP19 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 95%9705683 SARS-CoV-2-host interactions IFNA2 IFNA8 IFNA13 SNRPB IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 IFNB1 ISG15 SAR1B PATJ VPS39 VPS18 LARP1 IRAK1 VPS11 VPS16 IFNAR1 TLR1 CRB3 VPS33A TKFC G3BP1 SMN2 G3BP2 MBL2 YWHAE CNBP TLR2 VPS41 VPS45 SFTPD IL17RC IL17RA NLRP12 YWHAQ IL17F IL17A YWHAG GEMIN2 TUFM YWHAH GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 DDX20 TLR7 VPS33B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 STAT2 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 UBE2N HLA-H HLA-B HLA-C ATG14 HLA-F HLA-G HSP90AB1 HLA-E IKBKB YWHAB TRIM25 IKBKE AKT1 IRF7 NUP214 SFN YWHAZ IFIH1 JAK1 TRIM4 IKBKG TOMM70 RIPK2 TYK2 RPS27A UBE2V1 RNF135 TLR8 KPNA2 CAV1 MAP3K7 STAT1 NLRP3 SEC23A TBK1 B2M IRF3 STING1 MAVS HLA-A TAB1 GJA1 RIGI PALS1 NUP205 POM121 NUP107 NUP188 SEC24B AAAS NUP160 SEC24A POM121C NUP42 NUP85 TPR NUP62 UVRAG NUP88 MAP1LC3B NUP43 RAE1 HSP90AA1 NDC1 RANBP2 TRAF3 SEC13 TRAF6 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 BECN1 SEC24D NUP35 NUP54 SEC24C NUP37 NOD1 NOD2 AKT2 PDPK1 RPS27 PIK3C3 SNRPD2 SNRPD1 MASP1 SNRPD3 PIK3R4 TJP1 CHUK PTPN11 SIKE1 CREBBP PTPN6 IRAK2 SNRPG TAB3 TAB2 SNRPE IFNA5 IFNA4 IFNA7 IFNA6 SNRPF AKT3 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 95%5657562 Essential fructosuria KHK MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACOT11 ACADL ACOT12 HADHB ACOT13 HADHA ACADVL ACADM ACSM3 ACADS PCCA ECI1 THEM4 PCCB ACSM6 THEM5 ACAD11 NDUFAB1 ACAD10 MCAT ACBD7 ACBD6 ACOT7L ACSF2 MCEE ACOT2 DBI PCTP ECHS1 DECR1 ACOT9 ACOT7 MECR ACAA2 MMAA MMUT HADH ACOT1 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.3 Meiotic synapsis H2BC9 ACD TINF2 H2AZ2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 POT1 TERF2IP H2AC20 FKBP6 HSPA2 LMNB1 UBE2I TEX12 SYCP2 SYCP1 SYNE2 SYNE1 SMC1B REC8 SYCP3 BRCA1 STAG3 H2AX H2AB1 SYCE3 H2AC19 SYCE2 H2BC26 H2AC14 SYCE1 H2BC12L H2BC21 SUN2 SUN1 H2AC8 H2AC6 H2AC7 H2BC17 SMC1A SMC3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 STAG1 H2BC11 STAG2 RAD21 ATR DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis RIPK1 TRADD TRAF2 RIPK3 CASP8 FADD MLKL DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 95%1168372 Downstream signaling events of B Cell Receptor (BCR) RELA NFATC1 MAP3K7 NFKB1 NRAS RASGRP1 NFATC2 CHUK IKBKB CARD11 MALT1 NFKBIA FKBP1A PSMD8 PSMD6 PSMD7 RASGRP3 PSMD2 REL NFKBIE PSMD3 PSMD1 CALM1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 BCL10 PSMD14 BTRC PSMD13 NFATC3 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 IKBKG UBB PSMB2 PSMB3 UBC PSMB1 RPS27A FBXW11 ADRM1 PPIA PSMC5 PSMC6 HRAS PRKCB SEM1 PSMC3 PSMC4 PSMC1 PPP3CA PSMC2 PPP3CB SKP1 NFKBIB PPP3R1 CUL1 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2BC9 H2AZ2 H4C9 H2BC8 PIWIL2 H2BC5 TDRKH H2BC3 PIWIL1 HENMT1 H2BC1 ASZ1 MAEL MOV10L1 MYBL1 H2AC20 TDRD9 TDRD6 TDRD1 PLD6 TDRD12 FKBP6 DDX4 DGCR8 TNRC6C TSNAX AGO3 PRKRA DICER1 AGO4 TARBP2 TSN AGO1 AGO2 TNRC6A TNRC6B POLR2A POLR2B POLR2C HSP90AA1 POLR2D POLR2E RAN POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L IPO8 ELAC2 H2AX H2AB1 H2AC19 H2BC26 ANG H2AC14 BCDIN3D H2BC12L XPO5 H2BC21 DROSHA PIWIL4 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 H3C15 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 95%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 95%774815 Nucleosome assembly H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 RUVBL1 H2BC3 H2BC1 NPM1 H2AC20 ITGB3BP CENPA CENPC CENPT CENPU CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP SMARCA5 CENPQ CENPS CENPW CENPX OIP5 RBBP4 RSF1 RBBP7 MIS18A H2AX HJURP H2AB1 KNL1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 MIS18BP1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis BCL2 POU3F2 TNRC6C MOV10 AGO3 DICER1 AGO4 HDAC1 TRPM1 AGO1 AGO2 TNRC6A TNRC6B HINT1 BIRC7 BCL2A1 SIN3A PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 95%5654228 Phospholipase C-mediated cascade; FGFR4 FGF19 FGF18 FGFR4 FGF1 FGF2 FGF4 FGF6 FGF9 PLCG1 FGF20 FGF23 KLB FGF16 TBC RABGAPS%REACTOME%R-HSA-8854214.2 TBC RABGAPs MAP1LC3B ULK1 RAB8B RAB33B RAB33A TBC1D2 RAB5B RABEP1 RAB5C TBC1D3 TBC1D7 RAB7B RABGAP1 RAB11A RAB6A ARF6 RAB4A RAB11B RAB5A RABGEF1 TBC1D10A TBC1D10B GABARAPL2 SYTL1 RAB7A RAB6B RAB35 GGA2 TBC1D24 GGA1 TBC1D25 OPTN GGA3 TSC2 RAB8A TSC1 TBC1D20 GABARAP TBC1D13 TBC1D14 TBC1D17 TBC1D15 TBC1D16 TBC1D10C CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC2A6 SLC2A7 SLC5A1 SLC2A8 SLC5A2 FGF21 SLC50A1 SLC2A4 SLC2A9 SLC45A3 SLC2A1 SLC2A2 SLC2A3 SLC5A9 SLC60A2 SLC5A4 SLC2A14 SLC2A10 SLC2A11 SLC2A12 SLC5A10 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME%R-HSA-438064.5 Post NMDA receptor activation events RPS6KA1 NRAS ADCY1 ADCY8 MAPK1 PRKACG PRKACA PRKACB PRKAA1 PRKAA2 MAPK3 PRKAG1 PRKAG2 PRKAG3 PRKAB2 GRIA1 CAMK2B GRIA2 CAMK2D SRC ACTN2 PRKAB1 CAMK2A NRG1 GRIN2C GRIN2B NRGN RASGRF1 GRIN2D GRIN1 RPS6KA6 DLG1 GRIN2A DLG2 DLG3 LRRC7 DLG4 NEFL CALM1 CAMK2G CAMK1 GIT1 RASGRF2 PRKAR1B PRKAR2B RAC1 HRAS PRKAR1A PRKAR2A CAMK4 PRKX CAMKK1 CAMKK2 KPNA2 PDPK1 RPS6KA3 RPS6KA2 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 95%175474 Assembly Of The HIV Virion UBC RPS27A FURIN VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A PPIA VPS37B MVB12B MVB12A UBAP1 NMT2 UBB PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling FURIN PCSK6 LIPC CREB3L3 PCSK5 LIPG CETP APOA2 APOA1 APOA4 APOA5 APOE ANGPTL8 ANGPTL4 LPA MTTP LPL LMF2 LMF1 APOF GPIHBP1 FGF21 MBTPS1 APOC3 APOC2 ANGPTL3 ALB P4HB ABCG1 MBTPS2 APOB PLATELET SENSITIZATION BY LDL%REACTOME%R-HSA-432142.4 Platelet sensitization by LDL PPP2CA PPP2CB PECAM1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PTPN6 MAPK14 LRP8 APOB PLA2G4A PTPN11 PPP2R1B FGR PPP2R1A PPP2R5E BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 95%352238 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 95%5683678 Defective ABCA3 causes SMDP3 ABCA3 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 95%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 95%5689896 Ovarian tumor domain proteases RNF128 APC OTUD5 UBE2D1 TRAF3 ZRANB1 TRAF6 UBA52 OTUB1 RHOA CDK1 OTUB2 OTUD7A OTUD7B VCP IFIH1 NOD1 TRIM4 NOD2 VCPIP1 IKBKG UBB RIPK2 RIPK1 UBC RPS27A ESR1 TNIP1 MAVS TNIP2 TNIP3 OTUD3 RNF135 RIGI PTEN TNFAIP3 TP53 TRIM25 YOD1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 95%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CYP51A1 SREBF2 MSMO1 NSDHL HSD17B7 TM7SF2 SREBF1 DHCR24 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome RELA NFKB1 HSP90AB1 APP MEFV PANX1 PSTPIP1 HMOX1 TXNIP NFKB2 SUGT1 TXN CASP1 P2RX7 PYCARD NLRP3 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 95%5654716 Downstream signaling of activated FGFR4 FGF19 FGF18 SOS1 FGFR4 FGF1 FRS3 FGF2 FGF4 FGF6 PIK3R1 FGF9 NRAS PLCG1 FGF20 HRAS FGF23 GAB1 FRS2 KLB PIK3CA PTPN11 FGF16 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 95%5263617 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 95%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4P1 PIP4K2C IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 95%917937 Iron uptake and transport ATP6V0D1 FTH1 ATP6V0C ATP6V0D2 ATP6V1B1 FTL ATP6V1A IREB2 ABCG2 CP FBXL5 ATP6V0A2 CYBRD1 ATP6V1H ACO1 ATP6V0A4 SLC40A1 ATP6V0E2 ATP6V1G3 ATP6V1D ATP6V1C1 HEPH ATP6V1F ATP6V1C2 ATP6V0A1 TF SLC46A1 STEAP3 HMOX1 HMOX2 SLC22A17 FTMT MCOLN1 STEAP4 TFRC HFE GLRX3 UBA52 UBB TCIRG1 CAND1 UBC LCN2 RPS27A NEDD8 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 ATP6AP1 SKP1 TFR2 ATP6V1B2 SLC11A2 CUL1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.4 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 CRK PXN ARHGAP35 RASA1 NRAS RHOA ELMO1 RAC1 HRAS BCAR1 ELMO2 DOCK1 RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 95%8951430 RUNX3 regulates WNT signaling CCND1 RUNX3 CTNNB1 TCF7L2 TCF7L1 MYC LEF1 TCF7 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 95%389356 CD28 co-stimulation CD86 PPP2R5B CD80 PPP2R5A PPP2R5D LYN PPP2R5C PIK3R2 PIK3R1 PIK3CG PIK3R6 PIK3R5 THEM4 GRAP2 RICTOR MAP3K8 PPP2R1B PPP2R1A PIK3CB CDC42 PPP2CA PPP2CB MLST8 PIK3CD AKT2 CTLA4 MAP3K14 YES1 PAK1 PAK3 MTOR RAC1 LCK CD28 FYN PRR5 PDPK1 PAK2 AKT1 PIK3R3 PIK3CA VAV1 MAPKAP1 PPP2R5E AKT3 TRIB3 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 95%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA RPS6KA1 SOS1 CCKBR HBEGF MAPK7 EGFR NRAS MAPK1 HRAS MMP3 MAPK3 GAST RPS6KA3 RPS6KA2 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 95%5340588 Signaling by RNF43 mutants FZD5 FZD4 WNT3A FZD6 LRP5 RNF43 FZD8 LRP6 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 95%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle LIG1 BANF1 XRCC6 FEN1 XRCC4 KPNA1 XRCC5 LIG4 PPIA HMGA1 CCR5 CXCR4 PSIP1 CD4 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 95%9694493 Maturation of protein E UBC RPS27A UBA52 UBB MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 95%8851805 MET activates RAS signaling RANBP10 HRAS SOS1 MUC20 MET RANBP9 HGF NRAS CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RPS6KA1 NRAS MAPK1 MAPK3 RASGRF2 CAMK2B CAMK2D ACTN2 CAMK2A HRAS GRIN2B RASGRF1 GRIN2D GRIN1 RPS6KA6 PDPK1 DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RPS6KA3 CALM1 CAMK2G RPS6KA2 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX10 PPOX ALAS1 CPOX HMBS ABCG2 ALB UROD UROS ALAS2 COX15 ALAD FECH ATTENUATION PHASE%REACTOME%R-HSA-3371568.2 Attenuation phase CREBBP HSP90AA1 HSPA8 EP300 HSP90AB1 DNAJB1 HSPA1L HSBP1 PTGES3 HSPA2 HSF1 HSPA1A FKBP4 HSPA1B SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 95%9703465 Signaling by FLT3 fusion proteins SOS1 STAT5A STAT5B CDKN1A PIK3R1 NRAS TRIP11 GOLGB1 PIM1 HRAS ZMYM2 GAB2 MYO18A PIK3CA ETV6 NOX4 SPTBN1 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 95%190828 Gap junction trafficking CLTC CLTB CLTA AP2M1 GJC1 GJC2 GJA3 GJA10 GJA5 CLTCL1 GJA4 GJA9 GJA8 DNM1 GJD2 DNM2 GJB2 GJD4 MYO6 DAB2 GJB1 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GJA1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation OGDH GCSH GNMT DAO PXMP2 GLDC AGXT HOGA1 GOT2 KGD4 GRHPR DDO HAO1 AGXT2 AMT DLST ALDH4A1 PRODH2 DLD FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 95%9823739 Formation of the anterior neural plate POU3F1 PAX6 ZIC2 ZEB2 SOX2 POU5F1 NANOG ZNF521 SOX1 GBX2 OTX2 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 95%9851151 MDK and PTN in ALK signaling ALK PTN MDK PTPRZ1 DEGRADATION OF AXIN%REACTOME%R-HSA-4641257.3 Degradation of AXIN RNF146 PSMA5 PSMA6 PSMA3 PSMA4 AXIN2 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 TNKS PSMB4 PSMB5 UBB PSMB2 TNKS2 PSMB3 UBC PSMB1 RPS27A SMURF2 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMD8 PSMC1 PSMD6 PSMC2 PSMD7 PSMD2 PSMD3 PSMD1 AXIN1 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 95%2393930 Phosphate bond hydrolysis by NUDT proteins NUDT5 NUDT16 NUDT15 ADPRM NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling RGMB RGMA UNC5A UNC5B PLCG1 SIAH2 UNC5C UNC5D PITPNA AGAP2 WASL HJV SIAH1 PTPN11 CDC42 SLIT1 SLIT3 NEO1 DSCAM NTN4 MYO10 DCC DSCAML1 NTN1 TRIO NCK1 SLIT2 ROBO1 SRC RAC1 TRPC7 TRPC5 TRPC6 PRKCQ ABLIM1 TRPC3 ABLIM2 TRPC4 ABLIM3 TRPC1 PTK2 EZR DOCK1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 95%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A SS18 SMARCB1 SMARCD1 DPF1 BCL7A DPF2 BCL7C SMARCA2 BCL7B DPF3 SMARCA4 SMARCC1 SS18L1 ARID1A SMARCE1 ARID1B ACTB SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 95%1799339 SRP-dependent cotranslational protein targeting to membrane SRPRB SEC61A2 SEC61A1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TRAM1 RPS3A RPS26 SRP54 RPS25 RPS28 SSR4 RPS29 SSR2 RPS20 SSR3 SRP9 FAU RPS21 RPS24 RPS27 RPS23 SRP72 SRP68 SRP19 RPN2 RPN1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A RPL6 RPL7 RPL7A RPL18A RPL36AL DDOST RPL36 RPLP2 RPL35 RPL38 RPL37 RPL39 RPL21 RPL23 RPL22 RPL13A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 SRP14 RPL11 RPL36A RPL14 RPL13 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPL27A RPL22L1 RPL26L1 UBA52 SEC61G RPLP0 SEC61B RPS27A SSR1 SRPRA SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC26A2 SLC17A1 SLC26A11 SLC4A7 SLC26A1 SLC20A2 SLC4A8 SLC4A10 SLC4A9 SLC26A4 SLC26A7 SLC26A3 SLC26A9 SLC26A6 SLC13A1 SLC13A4 AHCYL2 SLC12A3 SLC12A1 SLC12A2 SLC12A4 SLC12A5 SLC4A2 SLC12A7 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 SLC12A6 SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC5A5 TRAFFICKING OF AMPA RECEPTORS%REACTOME%R-HSA-399719.3 Trafficking of AMPA receptors CACNG2 PRKCA CACNG3 CACNG4 AP2A1 GRIP1 NSF GRIP2 MYO6 EPB41L1 TSPAN7 GRIA1 CAMK2B GRIA2 CAMK2D MDM2 CAMK2A PRKCB PICK1 AKAP5 DLG1 PRKCG CACNG8 DLG4 GRIA3 CAMK2G GRIA4 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.6 Clearance of seratonin MAOA SLC6A4 ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription DDX5 ZCRB1 VHL RB1 ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME MAPDA NT5C2 ABCB1 ADH1A PCK1 ABCG2 SLC22A2 SLC22A3 SLC22A1 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 95%5467348 Truncations of AMER1 destabilize the destruction complex APC PPP2CA PPP2CB PPP2R5B PPP2R5A PPP2R5D PPP2R5C AMER1 GSK3B CSNK1A1 PPP2R1B AXIN1 PPP2R1A PPP2R5E DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 95%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 DIFFERENTIATION OF NAIVE CD+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME%R-HSA-9942503.2 Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells) IFNG RUNX1 RUNX3 STAT4 NFATC1 TPST2 TBX21 TNF CCL3 IL12RB2 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 95%15869 Nucleotide metabolism CDA ADSL PPAT GMPS NUDT13 ADSS1 ADSS2 GART PAICS PFAS NT5C DCTPP1 AGXT2 NT5C1A DPYS NME2 DPYD UPP2 NT5M XDH UPP1 UPB1 TYMP RRM1 RRM2B SAMHD1 DTYMK ATIC ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 TK1 ENTPD8 AK1 RRM2 AK2 NME1 AK4 AK5 AK6 AK7 AK8 AK9 GLRX NME3 NME4 DCTD CMPK1 TXNRD1 TYMS CTPS2 MAPDA CTPS1 GMPR2 GDA ADK AMPD1 NT5C2 NUDT5 GMPR DNPH1 AMPD2 AMPD3 NT5C1B NUDT16 DCK NUDT15 APRT ADPRM DGUOK PNP ITPA HPRT1 IMPDH1 IMPDH2 ADA UCKL1 UCK2 UCK1 PUDP TK2 NT5E ENTPD1 ENTPD5 TXN CAD DHODH UMPS GUK1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 95%168799 Clostridium neurotoxicity STX1B SNAP25 SYT2 STX1A SYT1 VAMP2 SV2C SV2B SV2A VAMP1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs PTGS2 ALOX15 ALOX12 ALOX5 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 95%209560 NF-kB is activated and signals survival IKBKB SQSTM1 UBC RELA RPS27A IRAK1 NGF NFKB1 NFKBIA TRAF6 UBA52 NGFR UBB HEMOSTASIS%REACTOME%R-HSA-109582.5 Hemostasis IFNA2 IFNA8 IFNA13 IFNA14 IFNA16 IFNA17 MFN1 MFN2 KLC1 KLC4 IFNA10 KLC3 GUCY1B2 KLC2 GUCY1B1 IFNA21 ATP2A3 ATP2A2 IFNB1 ATP2A1 SLC8A1 SLC8A2 PRKG2 NOS1 GUCY1A2 GUCY1A1 PTGIR IRAG1 PLA2G4A FGR STIM1 KCNMA1 ORAI2 SLC16A8 PECAM1 ORAI1 SLC16A3 PDE9A PDE1B PDE1A KIF5B ITPR1 KIF5A ITPR2 SLC16A1 ITPR3 SRI PSAP LRP8 PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS2 NOS3 PDE2A ATP2B4 VPS45 ATP2B3 ATP2B2 ATP2B1 PAFAH2 SLC8A3 P2RX7 P2RX6 P2RX5 P2RX4 PDE10A P2RX3 CRK P2RX2 P2RX1 GNAS SERPINB8 S100A10 C1QBP CABLES1 RAB5A MMP1 SLC3A2 SLC7A11 EPCAM SLC7A10 PRKCB SERPINC1 RAC1 VAV3 SERPIND1 PRKCQ SLC7A5 SLC7A6 SLC7A7 VAV1 SLC7A8 VAV2 SLC7A9 IRF1 IRF2 NFE2 V2-11 V3-4 V3-3 MPL V2-17 THPO V3-2 V2-15 V2-19 V1-11 GNA13 V1-16 V1-13 CAPZA2 SDC4 SDC2 SDC3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 GPC1 MAG V1-5 V1-3 V5-6 TBXA2R V4-6 V4-2 V4-1 SDC1 GATA3 LYN INPP5D PIK3CG PIK3R6 PIK3R5 CFL1 PF4 SERPINB2 ANXA2 MIF SOD1 CAPZA1 AAMP PPIA TUBA4A PRKCG TP53 PRKCE GNG10 GNG12 GNG11 GNG13 ITGA3 GNB2 GNAQ ITGA1 GNB1 MAFG ITGA6 GNB4 GNB3 GNB5 ABL1 GNGT1 GNGT2 WEE1 GNA14 OLR1 SPN VPREB3 VPREB1 GNG3 CXADR CDK5 GNA15 PSG1 PDPN PSG3 MPIG6B GNG2 SERPINB6 CLEC1B PSG2 GNG5 PSG9 GNG4 FCAMR GNG7 PSG8 GNA11 PSG5 GNG8 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 PF4V1 ARRB1 ARRB2 CEACAM5 CD48 SELPLG CD74 IGLL1 CD84 GRB14 PROCR JAML PSG11 CD99 SELE CD177 ESAM THBD SH2B2 ANGPT4 ANGPT2 MERTK CD2 CD244 ITGAM ITGB2 PPP2R1B PPP2R1A PIK3CB CAPZB PRCP PFN1 GATA6 TFPI F13B HRAS PCDH7 ZFPM1 PDPK1 RBSN SIRPG GRB7 KIF18A PIK3CA PIK3R3 ITGB1 PPP2R5E SOS1 PPP2R5B RAC2 PPP2R5A SHC1 PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 NRAS GP1BA RHOA HBB RHOB KIF2A MAPK1 KIF2C KIF2B FCER1G CEACAM3 MAPK3 PTPN1 PTPN11 CEACAM6 CEACAM8 CDC42 CD47 CD44 PPP2CA PPP2CB CD58 ITPK1 CENPE DGKG SRC DOCK5 DGKE ACTN2 DOCK4 DAGLA DGKD DOCK3 DGKB DGKA ABHD6 ABHD12 PLAU PRKCH DGKZ SIRPA DGKQ DAGLB DGKK DGKI DGKH CALM1 DOCK2 DOCK1 VEGFB VEGFC VEGFD THBS1 VEGFA SELL GNA12 CSK JAK2 FGB FGA VWF PLAUR FGG APBB1IP TLN1 VCL CEACAM1 SYK RAD51B LCK FYN F7 APP F9 F13A1 RAD51C POTEKP PROC ISLR F10 LAMP2 PROS1 HABP4 FAM3C CHID1 F2 GAS6 HGF APLP2 SERPINF2 ACTN4 GTPBP2 SYTL4 KIF28P TMX3 CD109 SELENOP SERPING1 TAGLN2 SCG3 NHLRC2 STXBP3 TEX264 STXBP2 ENDOD1 KIF5C PDGFB A1BG CLU KNG1 KIF21A CYB5R1 KIF21B RASGRP2 KIFAP3 APOH RASGRP1 VTI1B APOA1 RAP1B HSPA5 APOOL RAP1A PRKACG RARRES2 IGF2 RAF1 IGHV3-23 PRKACA RAB27B PRKACB IGF1 RAPGEF3 PPBP IGLV CYRIB RAPGEF4 IGLV2-8 MANF SELP IGKV1-16 TF KIF16B IGKV1-17 SCCPDH IGKV1-12 KIF20B CALU IGHV3-7 MAGED2 IGHV3-9 HRG IGHV3-30 FERMT3 LGALS3BP IGHV3-33 SERPINA3 KIF3B IGKV1D-39 A2M ORM1 IGKV1D-33 ECM1 SERPINA1 KIF3C WDR1 IGKV2D-28 PLEK IGKV4-1 OLA1 KIF18B IGHV7-81 CTSW KIF4B ORM2 SERPINA4 IGKV2D-30 KIF4A TMSB4X IGHV4-59 ALB IGHV1-69 PHACTR2 KIF12 TIMP3 PHF21A KIF11 QSOX1 PRTN3 TIMP1 IGLV2-11 SRGN IGLV1-40 CAP1 IGLV1-47 TRPC7 KIF15 ABCC4 AHSG KIF19 IGLV6-57 ANXA5 IGLV2-14 F5 IGLV1-44 TRPC6 KIF13B PLCG2 F8 TRPC3 KIF1C IGKV3-15 MMRN1 KIF1B TOR4A IGKV3-11 IGKV2D-40 CD63 IGHV3-11 ITIH4 KIF1A IGHV3-13 ITIH3 PLG IGLV7-43 IGKV1D-16 TTN IGKV1D-12 CLEC3B KIF25 IGLV1-51 CDC37L1 SPP2 IGLV2-23 KIF22 STX4 RCOR1 KIF6 LEFTY2 IGKV3-20 IGHM KIF27 LY6G6F LHFPL2 PCYOX1L IGHV4-34 IGHV1-2 KIF9 CD9 IGHV1-46 KIFC2 KIFC1 IGHV4-39 FLNA IGHV IGKV2-29 FN1 IGKV2-28 IGLC3 HMG20B PPIL2 IGLC1 IGLC2 F2RL2 ADAMTS13 F2RL3 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 F2R IGKC LAT IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 KIF26A IGLC6 IGKV1-5 KIF26B PRKAR1B PRKAR2B PRKAR1A PRKAR2A P2RY12 P2RY1 HDAC1 ACTN1 SIN3A CDK2 ADRA2C ADRA2B F3 ADRA2A SH2B3 AKT1 SERPINE2 GATA4 JMJD1C GP1BB GATA1 F12 HBE1 PRKCD F11 ZFPM2 PRKCA GATA5 GP5 SERPINA5 AK3 YWHAZ GP9 MICAL1 KLKB1 CARMIL1 HBG2 HBG1 EHD1 EHD2 EHD3 MAFF HBD AKAP10 DOCK10 DOK2 AKAP1 SH2B1 CABLES2 GP6 ITGA10 MAPK14 RACGAP1 CAV1 CFD JAM2 ANGPT1 JAM3 TEK ATP1B3 TGFB1 ATP1B2 ATP1B1 KIF3A PDE5A DOCK11 EGF PLCG1 DOCK6 DOCK9 DOCK8 DOCK7 PLAT MYB H3-3B F11R H3C8 PRKCZ KIF23 BCAR1 KIF20A ITGB3 ITGA2B GATA2 L1CAM H3C15 ITGAV ITGA5 BRPF3 TNFRSF10B SPARC TNFRSF10A SERPINE1 TNFRSF10D ITGAX KDM1A GNAT3 ITGA2 ITGAL TGFB2 TGFB3 ITGA4 TSPAN7 MGLL HDAC2 PICK1 GNAI3 GNAI1 CBX5 GNAI2 CD36 ALDOA TREM1 MAFK PTPN6 YES1 BSG IGHA1 PTK2 IGHA2 IFNA5 IFNA4 IFNA7 JCHAIN IFNA6 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress JUN CCAR2 DNAJC2 DNAJC7 CXXC1 COX5B RPS19BP1 HSPA4L COX5A HSPA14 RELA HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 ST13 COX6C HSPA7 HSPA12A HSPA12B IFNB1 COX6A1 NR3C1 COX6A2 G6PD COX6B2 COX6B1 HIGD1C GCLC GCLM IL6 APOB YWHAE GSK3A CDKN2D EED CDKN2C PDIA6 DNAJB11 CAT IGFBP7 WFS1 SOD2 CARM1 IL1A FBXL17 BACH1 PRKCI TLR4 DNAJC3 SLC7A11 LY96 MED1 OMA1 PRDX2 PRDX1 MAPK7 ADD1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 DNAJB1 HSPA1L PTGES3 NR1D1 HSPA2 DNAJA1 CAPZA3 MAPK8 ATF6 DNAJA4 CRYAB DNAJA2 MAP3K5 CAPZA2 FKBP4 DELE1 HERPUD1 ACTR10 HSPA1B MINK1 ETS1 ETS2 ERN1 HTRA2 CREB3 CREB3L4 SQSTM1 CREB3L1 CREB3L2 ERF TNIK EXTL2 HIF1AN SLC46A1 LONP1 CREBRF DCSTAMP MAP4K4 HSPB8 ATF6B EXTL3 UBE2D2 UBE2D3 HIF3A KEAP1 LIMD1 ELOB ELOC RBX1 AJUBA EPAS1 CUL2 HIF1A VHL EGLN1 EGLN3 AR EGLN2 WTIP CDKN2B NPLOC4 NRF1 RPLP0 UBXN7 DPP3 HSPA9 UFD1 TALDO1 SOD1 CAPZA1 CSNK2A1 FKBP14 IGFBP1 GPX1 GOSR2 CSNK2A2 MYDGF EXTL1 TATDN2 LMNA SSR1 CSNK2B DNAJB9 SULT1A3 TSPYL2 ZBTB17 TP53 KLHDC3 DDX11 WIPI1 PGR YIF1A ARFGAP1 RPS6KA3 PDIA5 CTDSP2 RPS6KA2 SRPRA RPS6KA1 SRPRB FKBP5 TPP1 PREB HDGF KDELR3 MAFG PGD MUL1 VCP MAP2K6 PRDX6 NLRP3 ESR1 CLEC1B MDM2 MDM4 GSTP1 NUP205 POM121 HMOX2 NUP107 NUP188 AAAS NUP160 POM121C GPX2 NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 SMARCD3 NUP133 NUP210 HMGA1 NUP153 NUP93 HDAC6 NUP50 NUP35 RBBP4 NUP54 NUP37 RBBP7 STIP1 TXNRD1 TCIRG1 DYNC1LI1 CAPZB DYNC1LI2 AKT2 GRB10 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V0B ATP6V0E1 ATP6V1G2 COX7A2L TXN RPS27 ATP6V1B2 EPO TRIB3 ATP6V0D1 CITED2 ATP6V0C ATP6V0D2 VENTX PPP2R5B ATP6V1B1 ATP6V1A SHC1 DYNLL1 ABCG2 DYNLL2 HBB ATP6V1H MAPK1 ATP6V0E2 NFYA ATP6V1G3 NFYB NFYC ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 DYNC1I2 BMAL1 MAPK3 COXFA4 DYNC1I1 COX7A2 COX7A1 CBX6 DYNC1H1 ABCC3 CAMK2B ABCC1 CAMK2D PLA2G4B CAMK2A HM13 EIF2AK3 NOX4 CAMK2G ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 HSPA6 UBE2D1 HSPE1 ANAPC10 HSPD1 ANAPC11 VEGFA CDC23 UBE2S CDC26 CDC27 CDC16 ANAPC4 ME1 ANAPC5 ANAPC1 ANAPC2 TXN2 MRE11 BRCA1 KAT5 NBN TLN1 RPA1 RPA2 PALB2 SEM1 RAD50 RPA3 SKP1 CCNA2 ATM CCNA1 ATR CUL1 CXCL8 CREB3L3 NUDT2 PRDX3 NOX5 NQO1 GSTA3 GSTA1 ERO1A SESN1 APOA1 SRXN1 HSPA5 HSBP1 CHD6 GPX3 HSF1 GPX6 GPX5 GPX8 GPX7 ATP7A BLVRB BLVRA CCL2 ABCF2 TXNRD2 SOD3 CCS CA9 MBTPS1 ALB P4HB MBTPS2 AQP8 DEFA5 BTRC RPS4Y2 RPS27L RPS4Y1 ATOX1 SZT2 RPS4X SAMTOR RPS15 SEH1L RPS14 NPRL2 RPS17 NPRL3 RPS15A STOML2 RPS16 GCN1 WDR59 RPS19 PHB2 EIF2AK4 RPS18 RPS3 FLCN MIOS RPS2 RPS11 ITFG2 IMPACT YME1L1 RPS10 DEPDC5 RPS13 KPTN WDR24 RPS12 RPS9 SH3BP4 RPS7 FNIP1 RPS8 FNIP2 RPS5 KICS2 CASTOR1 RPS6 CASTOR2 RPSA RPS3A RPS26 EEF1A1 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 NOTCH1 PTK6 CDKN1A CDKN2A HSP90AB1 SIN3A CDK2 PPP1R15A CEBPB EIF2AK1 CEBPG ASNS PRKAA2 SEC31A EIF2S2 ATF2 EIF2S1 MT-CO1 EIF2S3 EHMT2 DDIT3 EHMT1 CHAC1 ATF5 RPTOR ATF3 ATF4 TNRC6C CALR MOV10 MLST8 SLC38A9 ID1 MEF2C AGO3 AGO4 TKT MYC AGO1 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 TXNIP HMOX1 RRAGC MT-CO2 PSMD7 MT-CO3 RHEB RRAGB XPO1 PSMD2 RRAGD KHSRP AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 NUP214 LAMTOR5 DIS3 IDH1 PRKCD NCF1 PSMA5 NCF2 PPARGC1A PSMA6 NCF4 PSMA3 BAG4 PSMA4 PSMA1 PSMA2 MAPKAPK2 UBA52 ACTR1A DCP2 SERP1 PSMD12 PSMD11 PSMD14 PSMD13 PARN EZH2 PSMA7 PSMB6 EXOSC7 PSMB7 EXOSC6 CYBB PSMB4 EXOSC5 CYBA PSMB5 EXOSC4 UBB PSMB2 PSMB3 EXOSC9 UBC PSMB1 EXOSC8 RPS27A EXOSC3 EXOSC2 EXOSC1 CUL7 HSPA8 DCTN2 ADRM1 DCTN3 MAPK14 MAPK11 PSMC5 PSMC6 PSMC3 PGRMC2 PSMC4 PSMC1 PSMC2 SIRT1 HSPA1A SIRT3 PPARA CYCS HMGA2 H1-1 H1-0 H1-3 CUL3 LMNB1 CABIN1 H1-2 H1-5 H1-4 HIRA UBN1 EP400 ASF1A TRIM21 HSPH1 HYOU1 HBA2 RORA SESN2 MAP1LC3B ACADVL HSP90AA1 EGF RB1 CDKN1B FZR1 E2F1 E2F2 MAPKAPK5 E2F3 SKP2 CDK6 TFDP1 CCNE2 TFDP2 CDK4 CCNE1 H2AX H2AB1 H2AC19 HIGD1A H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 STAP2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 HSP90B1 KDM6B H3C15 RXRA ACD H2BC9 H2AZ2 TINF2 TERF1 H4C9 TERF2 H2BC8 H2BC5 H2BC3 STAT3 H3-4 H2BC1 POT1 NFKB1 TERF2IP H2AC20 RPL4 RPL5 HDAC3 RPL30 RPL3 RPL32 RPL31 RPLP1 NRIP1 RPL34 RPL10L COX4I1 RPL8 COX4I2 RPL10A TBL1X RPL6 RPL7 NCOA1 RPL7A RPL18A FABP1 RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 NCOR2 ARNT RPL39 RPL21 RPL23 NCOR1 RPL22 BMI1 TBL1XR1 RPL13A RPL9P9 RING1 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 RNF2 RPL11 RPL36A SUZ12 RPL14 CBX8 PHC2 RPL13 PHC1 RPL15 RPL18 RPL17 CBX4 RPL19 RPL39L CBX2 RPL41 PHC3 RPL35A AMER1 RPL23A GSK3B RPL3L RPL27A RPL22L1 RPL26L1 NCOA2 NCOA6 CRTC2 CRTC3 CRTC1 CLOCK MAP2K3 NPAS2 HELZ2 MAP2K4 RAI1 CREBBP MAPKAPK3 SP1 CHD9 BCL2 PDGFA MAFK AREG NFE2L2 BCL2L1 MAPK9 TGS1 MEF2D MAP2K7 MAPK10 COX7B FOS GFPT1 FOXO3 COX7C EDEM1 SYVN1 COX8A COX8C AKT3 HIKESHI KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 95%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB MECR HADHA ECHS1 ACADM HADH SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 95%187687 Signalling to ERKs NTRK1 KIDINS220 SOS1 CRK SHC1 NGF MAPKAPK2 NRAS RALA MAPK1 RAP1A MAPK3 BRAF RAPGEF1 MAPKAPK3 MAPK14 MAPK11 YWHAB SHC2 HRAS SHC3 RALGDS RALB MAPK12 MAPK13 FRS2 RIT1 MAP2K1 RIT2 CRKL MAP2K2 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.1 Dengue Virus Infection SNRNP200 HDLBP SRSF6 KDELR1 SRSF7 AP2A1 SNRPB AP2A2 SRSF9 DDX5 BAG2 PRPF8 AP2M1 CLU CPSF4 CPSF1 APOA1 HSPA5 FUS ALYREF CPSF3 CPSF2 CWC15 COG1 PRKG2 CD209 RTN3 CHERP ISY1 AP2S1 DDX46 DDX42 YBX1 PTBP1 AP2B1 HAVCR1 BCAS2 P4HB RBM5 CTNNBL1 RBM17 BUD31 MBL2 PLRG1 PRR5 SNRPA1 DNAJC8 RBM22 SRSF1 PRCC DDX23 C4A CSTF2T U2AF1 U2AF1L4 EXOC1 FIP1L1 PABPN1 IPO7 PUF60 DNAJB11 U2AF2 P4HA1 P4HA2 SNRPB2 CD14 P4HA3 SMNDC1 DNAJC10 NMT1 HNRNPA3 GBF1 PPIL1 VTN GPKOW CDC5L U2SURP SNRNP40 KPNB1 PPIL3 PPIL4 TLR4 DNAJC3 HNRNPA1 STAT2 LY96 RPSA MAPKAP1 PDCD6IP FASN C4BPA C4BPB RPN2 TUSC3 ATG14 RPN1 HSP90AB1 MAGT1 CTNNB1 DNAJA2 C4B_2 OST4 SDC4 ATG7 HSPA1B SDC2 DDOST SDC3 TMEM258 RPTOR DAD1 OSTC CALR CANX ACOT2 MLST8 STT3A STT3B EIF4E GPC1 GPC3 UBE2I GPC2 MRC1 GPC5 SUMO1 RETREG1 GPC4 GRPEL1 C1QA MTOR GPC6 C1S ELAVL1 H2AC17 H2AC12 XPO1 TRIM25 SDC1 IKBKE POLR2A POLR2B POLR2C POLR2D XRN1 LYN POLR2E POLR2F POLR2G PABPC1 POLR2H UBA52 POLR2I POLR2J NPLOC4 POLR2K POLR2L H2AC25 NEK2 H2AC21 PDIA3 GTF2F1 CLDN1 GTF2F2 IFIH1 UFD1 UBB UBC RPS27A HSPA8 UBA7 UBA6 UBA5 UBR4 NRBP1 HSPA1A KPNA2 EIF4G1 PEX19 RNASEK ATL2 LY6E KPNA7 NACA KPNA4 HNRNPA0 TIMD4 KPNA5 CD2BP2 KPNA3 HNRNPUL1 TYRO3 BTF3 FURIN AUP1 UBA3 PPIL6 MAPRE3 EMC4 UBA1 ELAVL2 RICTOR H2AC1 CPSF7 SPCS3 SRRM1 SPCS2 VCP CLINT1 SPCS1 SEC11A SEC11C VIM HNRNPC RIPK1 RBMX STING1 NFKBIA SCAP MAVS HYOU1 CLEC5A MAP1LC3B HSP90AA1 KPNA1 H2BC18 MERTK BECN1 DAXX EIF4E3 H2AC19 AXL H2BC26 H2AC14 EIF4G3 EIF4G2 H2BC21 SUN2 TSG101 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 TAL1 H2BC11 EIF4A3 HNRNPU HNRNPR CCAR1 PIK3C3 H3C15 SNRPD2 H2BC9 SNRPD1 CLP1 H4C9 H2BC8 SNRPD3 H2BC5 SRRM2 H2BC3 AQR PIK3R4 H2BC1 CRNKL1 PIK3R1 CDC40 H2AC20 DHX9 HSPG2 CD33 CSTF3 CSTF2 TJP1 PCBP1 PCBP2 CSTF1 DHX38 SYMPK RBM10 AGRN HNRNPL HNRNPM SNW1 HNRNPK CAMK2B HNRNPF HNRNPD CAMK2D RNPS1 SUGP1 CAMK2A PRPF19 PQBP1 TAOK1 PCF11 DHX15 DHX16 RPL18 WDR33 CD300A HNRNPH1 CAMK2G HNRNPH2 SF3B4 SF3B5 CDC73 SF3B2 SF3B3 SF3B6 SRRT SKIC8 SF3B1 SRSF11 CTR9 DDX3X RTF1 SF3A3 DPM1 SF3A1 DPM2 SF3A2 DPM3 LEO1 XAB2 PAF1 NUDT21 PHF5A HNRNPA2B1 CWC25 DYNLT1 CWC27 EFTUD2 MMP9 RRBP1 CWC22 PAPOLA CGAS NCBP1 NCBP2 TXNL4A SNRPN NCL WBP11 PRPF6 SNRPG SRSF2 PROS1 PPIE NFKBIB SRSF3 F2 SNRPE GAS6 SRSF4 SNRPF SRSF5 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 95%1592389 Activation of Matrix Metalloproteinases MMP15 COL18A1 MMP17 KLKB1 FURIN CMA1 ELANE CTSG PRSS2 MMP8 MMP9 KLK2 MMP25 MMP1 TIMP2 MMP2 PRSS1 CTRB2 SPOCK3 CTRB1 TIMP1 MMP3 CTSV MMP24 TPSAB1 MMP7 MMP13 CTSK MMP10 PLG MMP11 MMP14 MMP16 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 95%354192 Integrin signaling SOS1 CRK SHC1 FN1 RASGRP2 RASGRP1 RAP1B RAP1A CSK FGB RAPGEF3 FGA RAPGEF4 VWF PTPN1 FGG APBB1IP TLN1 SRC SYK BCAR1 PDPK1 AKT1 PTK2 ITGB3 ITGA2B METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 95%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se AHCY CBS MAT1A NNMT GNMT CTH SCLY HNMT SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 95%9958517 SLC-mediated bile acid transport SLC10A6 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC5A7 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME%R-HSA-9617324.2 Negative regulation of NMDA receptor-mediated neuronal transmission CAMK1 CAMK2B CAMK2D ACTN2 CAMK2A GRIN2C CAMK4 GRIN2B GRIN2D GRIN1 DLG1 GRIN2A DLG2 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL CALM1 CAMK2G ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.7 Enzymatic degradation of dopamine by COMT MAOA TOMT COMT MPS IIID - SANFILIPPO SYNDROME D%REACTOME DATABASE ID RELEASE 95%2206305 MPS IIID - Sanfilippo syndrome D GNS CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-HSA-373076.10 Class A 1 (Rhodopsin-like receptors) CXCL6 CXCL9 CXCL8 CXCL13 CXCL3 CXCL2 CXCL5 CX3CL1 CXCL16 CCRL2 CCR9 CCR8 CCR7 KNG1 CCR4 CCR3 CCL13 CCL11 CCL3L3 CX3CR1 CXCR5 CCR5 CXCR6 CXCR4 CCL7 NPFFR2 CCR6 CCL5 OXTR PPBP CXCR3 NPFFR1 CCL4 CCL3 GRPR AVPR1B CYSLTR1 CCL2 EDNRA OPN3 CCL1 RRH EDNRB CCL19 PTGIR PROK2 CCR2 RGR CCL17 AVPR2 PROK1 AVPR1A CCL16 OPN5 UTS2R CCR10 NPFF CCL25 TRHR CCR1 UTS2B CCL22 AGTR1 CCL21 FPR2 CCL20 LPAR4 CXCL10 HCRT CXCL11 RXFP4 NTSR1 CXCL12 MRGPRD NTSR2 ACKR4 GPR17 ACKR3 RXFP1 NMB ACKR2 RXFP2 XCR1 CCL28 RXFP3 NMBR CCL27 PSAP LPAR6 CMKLR1 NMS PDYN NMU AGTR2 GNRH2 FPR3 GNRH1 GALR3 QRFP GALR2 MLN GALR1 BRS3 NPBWR1 NPBWR2 GPR132 CCKAR GNRHR GPR183 FFAR4 PNOC FFAR3 GPR18 FFAR2 SSTR3 GPR39 EDN1 GPR37 ANXA1 EDN2 GPR35 EDN3 GPR31 CCKBR GPHA2 NPSR1 GRP GPR55 PTAFR NPS GPHB5 PLPPR1 PROKR1 LHCGR PLPPR2 PROKR2 MTNR1A PLPPR3 KISS1R MTNR1B MCHR1 PLPPR4 P2RY10 RLN2 PLPPR5 P2RY11 RLN3 LPAR1 ECE1 LPAR2 GPR4 ECE2 LPAR3 PRLHR LPAR5 MT-RNR2 INSL3 F2RL1 CHRM2 INSL5 S1PR1 PENK F2RL2 CHRM3 S1PR3 F2RL3 CHRM1 S1PR2 APLN GPR37L1 GPR68 CHRM4 S1PR5 GPR65 CHRM5 S1PR4 KEL PMCH NLN CYSLTR2 PPY MC1R GHSR MC4R OXGR1 F2R GPBAR1 LTB4R2 MC3R UTS2 GAL NTS FSHR MCHR2 NPB OPN4 NPW NMUR2 PRLH NMUR1 MAS1 MLNR XK OXT MC5R TRH NPY2R LTB4R NPY1R APLNR SUCNR1 BDKRB2 HCAR2 BDKRB1 HCAR3 QRFPR GNRHR2 HCAR1 XCL2 XCL1 PYY HTR2B HTR2C HEBP1 ADRB1 P2RY12 ADRA1D P2RY6 P2RY13 HTR2A P2RY2 P2RY14 ADRA1B P2RY1 HTR4 P2RY4 ADORA3 ADRA1A CCK ADORA1 HRH1 GPER1 HCRTR2 HTR6 HCRTR1 TAAR3P NPY5R KISS1 HTR7 SSTR1 CGA HRH3 SSTR2 HRH2 HRH4 SSTR4 DRD1 SSTR5 DRD2 CORT DRD3 NPY4R C3AR1 DRD4 OPRL1 DRD5 HTR1E CNR2 TAAR8 CNR1 HTR1F TSHR TAAR9 OPRD1 ACKR1 TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 FSHB ADRA2C C5AR2 HTR5A ADRA2B TAAR1 C5AR1 ADRA2A GPR143 C5 ADRB3 PTGER4 PTGFR PTGER1 TBXA2R PTGDR2 PTGER2 PTGER3 PTGDR ADORA2A AGT TSHB PF4 C3 FPR1 FFAR1 ADRB2 OPN1LW LHB ADORA2B OXER1 OPN1MW RHO NPY CXCR1 CXCR2 OPRM1 SST OPN1SW OPRK1 POMC CXCL1 AVP TACR2 TACR3 TAC3 TACR1 TAC1 APP SAA1 F2 MC2R TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%977068 Termination of O-glycan biosynthesis MUC15 MUC13 MUCL1 MUC3A MUC5AC MUC3B ST6GALNAC3 MUC1 ST6GALNAC4 MUC2 MUC7 MUC4 MUC6 MUC16 MUC17 MUC19 ST3GAL4 MUC5B MUC20 MUC21 ST3GAL1 ST3GAL2 ST3GAL3 ST6GALNAC2 MUC12 ST6GAL1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.2 Defective F9 variant does not activate FX F9 F10 F8 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching RFC5 PCNA POLD3 RFC3 POLD4 RFC4 POLD1 POLD2 RFC2 RFC1 PRIM2 PRIM1 POLA1 POLA2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 95%75108 Activation of BID and translocation to mitochondria BID CASP8 GZMB NMT1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 GTF2H4 GTF2F2 CTDP1 GTF2H5 CDK7 ERCC3 SUPT4H1 ERCC2 MNAT1 NELFB NELFCD NELFA NELFE NCBP1 NCBP2 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 95%166208 mTORC1-mediated signalling RPTOR EEF2K EIF4EBP1 MLST8 SLC38A9 EIF4E EIF4B YWHAB RPS6 MTOR FKBP1A RRAGA RRAGC RPS6KB1 RHEB RRAGB EIF4G1 RRAGD AKT1S1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 95%140342 Apoptosis induced DNA fragmentation KPNA1 H1-1 H1-0 DFFB H1-3 DFFA HMGB2 HMGB1 H1-2 H1-5 H1-4 KPNB1 CASP3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 95%5685942 HDR through Homologous Recombination (HRR) PCNA POLH MUS81 SLX4 EME1 EME2 GEN1 SLX1B SPIDR FIGNL1 UBA52 FIRRM BLM MRE11 RTEL1 BRCA1 BRCA2 RAD51AP1 WRN BRIP1 KAT5 EXO1 CHEK1 RBBP8 NBN UBB TOPBP1 ATRIP BARD1 RFC5 UBC RMI2 POLD3 RFC3 POLD4 POLK RFC4 POLD1 RPS27A POLE RMI1 POLD2 RFC2 RFC1 XRCC2 TOP3A XRCC3 RPA1 HUS1 RPA2 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C POLE4 RPA3 RAD17 RAD1 ATM DNA2 RAD9B RHNO1 POLE2 POLE3 ATR RAD9A RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 95%8934903 Receptor Mediated Mitophagy MAP1LC3A FUNDC1 ATG5 CSNK2B MAP1LC3B ATG12 ULK1 CSNK2A1 CSNK2A2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH12 RDH8 RBP1 LRAT STRA6 TTR RDH5 RLBP1 RDH11 ABCA4 RDH10 RDH16 SDR9C7 RPE65 RHO MYO7A DHRS9 CYP4V2 RBP3 HSD17B6 HSD17B1 RBP4 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 95%3371556 Cellular response to heat stress CCAR2 DNAJC2 DNAJC7 RPS19BP1 HSPA4L HSPA14 HSPA13 BAG5 DNAJB6 BAG2 BAG3 BAG1 HSPA4 HSP90AB1 ST13 HSPA7 HSPA12A DNAJB1 MAPK1 HSPA12B HSPA1L HSPA5 HSBP1 PTGES3 HSF1 HSPA2 CRYAB VCP FKBP4 MAPK3 HSPA1B RPTOR MLST8 CAMK2B HSPB8 CAMK2D HSPH1 CAMK2A MTOR YWHAE NUP205 AKT1S1 POM121 NUP107 NUP188 AAAS GSK3B NUP214 NUP160 POM121C CAMK2G NUP42 NUP85 TPR NUP62 BAG4 NUP88 HSPA6 NUP43 HSP90AA1 RAE1 NDC1 MAPKAPK2 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 HDAC6 NUP35 NUP54 NUP37 HSPA9 CREBBP EP300 HSPA8 RPA1 RPA2 EEF1A1 SIRT1 RPA3 HSPA1A ATM ATR HIKESHI CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes NCAPH CSNK2B SMC4 SMC2 CCNB2 CCNB1 NCAPD2 CSNK2A1 CDK1 NCAPG CSNK2A2 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 95%6802952 Signaling by BRAF and RAF1 fusions KDM7A NRAS MAPK1 RAP1B RAP1A RAF1 BCL2L11 PAPSS1 ATG7 MAPK3 TRAK1 CAMK2B CAMK2D SRC YWHAB CAMK2A AGK ARRB1 ARRB2 MPRIP SND1 ZC3HAV1 CALM1 CAMK2G IQGAP1 FAM114A2 QKI KIAA1549 ESRP1 TRIM24 FXR1 FN1 AGTRAP ARAF AP3B1 PEBP1 CSK AGGF1 JAK2 TENT4A MARK3 FGB FGA VWF KSR1 FGG BRAF KSR2 FAM131B CNKSR2 APBB1IP CNKSR1 TLN1 CLCN6 VCL AKAP9 HRAS LMNA MAP2K1 MAP2K2 ITGB3 ITGA2B VLDLR INTERNALISATION AND DEGRADATION%REACTOME DATABASE ID RELEASE 95%8866427 VLDLR internalisation and degradation NR1H2 CLTC PCSK9 NR1H3 UBC AP2S1 CLTA AP2A1 VLDLR RPS27A AP2A2 AP2B1 UBA52 AP2M1 MYLIP UBB DRUG ADME%REACTOME DATABASE ID RELEASE 95%9748784 Drug ADME UGT2B7 SLCO1B1 SLCO1B3 GSTA1 ABCC2 XDH GGT5 GGT7 GGT6 CNDP2 GGT3P GGT1 SLC16A1 ALB ACY1 SLC22A3 GSTP1 ABCC4 CES1 SLC22A2 SLC22A1 CYP2C9 CYP2C8 CYP2C19 MAPDA ADK AKR1C1 PNP CYP2D6 HPRT1 SLC22A7 IMPDH1 ADA IMPDH2 SULT2A1 CES2 SLC28A2 RAC1 SLC29A1 VAV3 SLC29A3 SLC29A2 SLC28A3 VAV1 VAV2 CYP2E1 HSD11B1 ABCG2 HSD11B2 GMPS TPMT GSTT1 UGT1A3 PCK1 GSTM1 NME2 SERPINA6 SULT1A1 SULT1E1 ACSM2B SULT1A4 ABCC3 ABCC1 SULT1C4 BCHE PON3 PON1 NME1 NAT1 NAT2 SLCO1A2 ABCC5 NT5C2 ABCB1 NUDT15 ADH1A GSTA2 UGT1A10 ITPA UGT2B28 UGT1A5 UGT1A4 UGT3A2 SLC22A8 UGT2A3 UGT2A2 UGT3A1 SULT1A3 UGT2A1 GLYATL3 UGT1A8 BSG GLYATL2 UGT1A7 GLYATL1 UGT1A6 UGT2B10 ACSM2A CYP3A4 ACSM5 UGT2B11 GLYAT UGT1A1 ACSM4 UGT2B15 UGT2B17 UGT1A9 GUK1 UGT2B4 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME%R-HSA-964739.2 N-glycan trimming and elongation in the cis-Golgi MAN1C1 MAN1A2 MGAT1 MAN1A1 MANEA RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 95%5668599 RHO GTPases Activate NADPH Oxidases NCF1 PRKCA NCF2 NCF4 RAC2 PIK3R4 NOXA1 NOXO1 NOX3 MAPK14 PRKCZ MAPK11 NOX1 PRKCB MAPK1 RAC1 S100A9 PIN1 S100A8 CYBB CYBA MAPK3 PIK3C3 PRKCD NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 95%5654732 Negative regulation of FGFR3 signaling PPP2CA FGF18 PPP2CB UBC FGF1 FGF2 RPS27A FGF4 CBL FGF9 UBA52 FGF20 MKNK1 SPRY2 MAPK1 FGF23 FRS2 MAPK3 BRAF PTPN11 UBB FGF16 PPP2R1A KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway MAFG RELA PGD NQO1 GSTA3 MUL1 GSTA1 SESN1 SRXN1 CHD6 CUL3 VCP CCL2 ABCF2 SOD3 G6PD GCLC GCLM TRIM21 SESN2 MAP1LC3B EGF BTRC SKP2 FBXL17 BACH1 PRKCI TXNRD1 SLC7A11 EP300 AKT2 TXN NOTCH1 PRDX1 NFKB1 CDKN1A ABCG2 CDKN2A PRKAA2 SQSTM1 ATF4 TKT ABCC3 MYC ABCC1 PSMD8 KEAP1 PSMD6 HMOX1 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 EIF2AK3 AMER1 GSK3B IDH1 PRKCD PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 NPLOC4 PSMD11 ME1 PSMD14 UBXN7 PSMD13 PSMA7 BRCA1 PSMB6 PSMB7 PSMB4 DPP3 UFD1 PSMB5 UBB PSMB2 PSMB3 CREBBP TALDO1 UBC SP1 BCL2 PSMB1 PDGFA MAFK RPS27A AREG NFE2L2 BCL2L1 ADRM1 CSNK2A1 PALB2 PSMC5 CSNK2A2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SKP1 CUL1 AKT3 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex PER2 PER1 CREBBP PER3 CRY2 CRY1 BMAL1 CSNK1D KMT2A CSNK1E CLOCK NPAS2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 95%5579006 Defective GSS causes GSS deficiency GSS RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle TFRC VANGL1 WDR11 SLC4A7 UACA RHOH TMEM59 JUP TUBA1B ROCK1 ARHGDIB ROCK2 CSK RALGAPA1 FAM91A1 VCP NSFL1C DBN1 VAMP3 RAB7A SLC1A5 NIPSNAP2 PAK6 ARHGDIG STOM PAK1 PAK5 LCK MTR ARHGDIA PAK2 ZAP70 LAMTOR1 PAK4 OSBPL11 DBT CAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 95%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 AP1S1 AP1S3 B2M AP1M2 AP1M1 AP1B1 HLA-A PACS1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLCO4A1 SLC26A2 SLC22A5 SLC17A1 SLC24A2 SLC24A3 SLCO2B1 SLC41A2 SLC5A1 SLC26A11 SLC41A1 SLC5A2 SLC30A10 SLC16A2 SLC39A6 SLCO1B1 SLC39A5 SLC26A1 SLCO1B3 SLC39A8 SLC15A1 SLC39A7 SLC14A1 CTNS CP SLC39A2 SLC15A3 SLC14A2 SLC6A5 SLC39A1 SLC15A4 SLC4A10 SLC39A3 SLC2A9 SLC30A8 SLC26A4 SLC30A3 SLC26A7 SLC30A2 SLC26A3 SLC31A1 SLC26A9 SLC30A5 SLC26A6 SLC40A1 SLC39A10 SLC25A1 SLC2A1 SLC30A1 SLC2A2 SLC6A2 SLC39A14 SLC13A1 SLC6A3 SLC8B1 SLC8A1 SLC13A2 SLC22A12 SLC8A2 SLC13A3 HEPH SLC13A4 SLCO1C1 SLC2A10 SLC47A2 SLC47A1 SLC5A12 SLC5A10 SLC25A26 SLC24A4 SLC16A7 SLC16A8 EMB SLC11A1 SLC16A3 SLC13A5 FGF21 RSC1A1 AHCYL2 SLC17A8 SLC12A3 SLC16A1 SRI SLC12A1 SLC24A5 SLC22A4 SLC22A3 SLC22A6 SLC45A3 SLC10A6 SLC22A15 SLC22A16 SLC22A11 SLC20A1 SLC8A3 SLC2A6 SLC2A7 SLC2A8 PDZD11 SLC50A1 SLC4A8 SLC4A9 SLC6A20 SLC35B3 SLC43A2 LCN9 SLC1A1 SLC35B2 SLC43A1 SLC27A1 SLC1A2 SLC35B4 SLC3A1 SLC35D1 SLC1A3 SLC35D2 SLC1A4 LCN15 SLC3A2 LCN12 SLC7A11 SLC7A10 SLC35A2 SLC1A6 SLC35A3 SLC33A1 SLC1A7 SLC5A6 SLC7A1 ARL2BP SLC7A3 LCN1 SLC25A29 SLC29A4 SLC38A3 SLC27A6 SLC38A2 SLC28A2 SLC36A4 SLC29A1 SLC38A5 SLC2A13 SLC28A1 SLC38A4 SLC29A3 SLC36A1 SLC5A11 SLC6A19 SLC5A3 SLC29A2 SLC28A3 SLC38A1 SLC27A4 SLC36A2 SLC6A15 SLC6A14 SLC6A12 SLC16A10 SLC7A5 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC5A5 SLC32A1 SLC6A13 SLC20A2 SLC6A1 SLC6A9 SLC17A6 SLCO1A2 SLC1A5 ARL2 SLC67A1 SLCO4C1 SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC22A2 SLC22A1 SLC25A5 SLC25A4 SLC25A6 SLC22A7 SLC12A2 RUNX1 SLC12A4 SLC6A7 SLC12A5 SLC12A7 SLC6A11 SLC25A18 SLC25A11 SLC6A4 APOD SLC17A7 SLC25A22 SLC2A3 CALM1 SLC35C1 SLC4A7 SLC25A10 SLC24A1 SLC17A5 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 AVP SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC2A4 SLC35A1 SLC22A8 SLC4A2 SLC4A1 SLC4A3 SLC4A5 SLC4A4 SLC5A8 BSG SLC5A9 SLC12A6 SLC60A2 SLC39A4 SLC34A3 SLC5A4 SLC34A2 SLC2A14 SLC34A1 SLC2A11 SLC11A2 SLC2A12 SLC5A7 SLCO2A1 DIMERIZATION OF PROCASPASE-8%REACTOME%R-HSA-69416.5 Dimerization of procaspase-8 RIPK1 TRADD TRAF2 TNFSF10 TNFRSF10B TNFRSF10A FAS CASP8 FASLG FADD MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 95%912446 Meiotic recombination H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H3-4 H2BC1 H2AC20 CDK2 MLH1 FIGNL1 TEX15 MSH4 MSH5 MND1 FIRRM BLM MRE11 BRCA1 BRCA2 DMC1 PSMC3IP MLH3 CDK4 RBBP8 H2AX PRDM9 NBN H2AB1 H2AC19 H2BC26 H2AC14 SPO11 H2BC12L H2BC21 TOP3A H3-3B RPA1 H3C8 H2AC8 RPA2 H2AC6 H2AC7 H2BC17 RAD50 H2BC12 H2BC13 RAD51 H2BC14 RAD51C H2AJ RPA3 H2BC15 H2BC11 ATM H3C15 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 95%2871796 FCERI mediated MAPK activation JUN IGHV3-23 IGLV IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV4-59 IGHV1-69 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 IGHV4-39 IGHV PLCG1 IGKV2-29 IGKV2-28 IGLC3 GRAP2 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 IGHV2-70 IGHV2-5 IGLV3-1 LCP2 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 IGLC7 IGHV3-53 IGKV5-2 IGLC6 IGKV1-5 RAC1 HRAS VAV3 VAV1 VAV2 SOS1 V2-11 V3-4 NRAS V3-3 V2-17 IGHE V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 MAPK8 MAPK3 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 LYN MAP2K4 MAPK9 SYK PAK1 MAP2K7 MAP3K1 MAPK10 FOS PAK2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 95%2474795 Diseases associated with visual transduction RDH12 OPN1LW RBP1 OPN1SW NAPEPLD LRAT STRA6 TTR RDH5 RLBP1 ABCA4 OPN1MW RBP4 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 HES5 APH1A DLL4 PSENEN NCSTN APH1B PSEN2 ADAM10 TACC3 MAMLD1 PSEN1 RBPJ SMAD3 ACTA2 SNW1 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 AKT1 PSMD1 FLT4 YWHAZ PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 HES1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 CREBBP UBC MAML2 PSMB1 MAML1 RPS27A HEY1 KAT2B KAT2A EP300 HEY2 JAG1 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 MAML3 NOTCH2 NOTCH1 CUL1 NOTCH4 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 EED UXT PCGF6 RRM2 EPC1 CDC7 E2F1 RBBP4 EZH2 BRCA1 RYBP RBBP7 TFDP1 TFDP2 CHEK1 RBBP8 YAF2 EHMT2 EHMT1 MAX BMI1 CBX3 RING1 L3MBTL2 RNF2 E2F6 SUZ12 RAD51 PHC1 CBX5 MGA PCGF2 PHC3 APAF1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 GLRX5 FDX1 FXN SLC25A28 FDX2 SLC25A37 LYRM4 FDXR HSCB RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 95%611105 Respiratory electron transport CYCS MT-ND6 COX5B COX5A MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 CMC1 PYURF SCO1 UQCRC1 COX6C TMEM126A UQCRC2 TMEM126B TRAP1 SURF1 COX6A1 COX6A2 NDUFAF8 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 COX6B2 NDUFAF2 SFXN4 COX6B1 NDUFAF3 NDUFAF1 HIGD1C HCCS TMEM186 RAB5IF OXA1L ACAD9 COQ10B COQ10A TMEM177 DMAC1 DMAC2 UQCR11 UQCR10 PET117 TIMMDC1 PET100 MDH1 MDH2 NUBPL LETM1 LYRM2 LYRM4 LYRM7 NDUFA13 NDUFA11 NDUFA12 TACO1 NDUFA10 NDUFAB1 SDHC SDHD SDHA SDHB NDUFB10 UQCRB COX16 COX15 NDUFB11 COX18 HIGD1A UQCRH COX11 COX14 NDUFV3 NDUFV2 NDUFV1 COA3 COA1 NDUFA5 GOT1 UQCC3 COX7A2L UQCC2 UQCC1 UQCC6 UQCC5 HIGD2A UQCRQ MT-CYB COX20 ETFA ETFB TMEM223 UQCRFS1 COA5 NDUFC2 NDUFC1 SLC25A18 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 SLC25A11 SMIM20 NDUFB9 NDUFB7 NDUFB6 COX4I1 NDUFB5 COX4I2 NDUFB4 NDUFB3 NDUFB2 ETFDH NDUFB1 FOXRED1 MT-CO1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 BCS1L COXFA4 NDUFA6 COX7A2 NDUFA3 COX7A1 NDUFA2 NDUFA1 COX19 TTC19 COX17 UQCRHL SCO2 MT-CO2 MT-CO3 CYC1 NDUFS3 GOT2 HSCB ECSIT HSPA9 TIMM21 SLC25A12 FXN SLC25A13 NDUFB8 COX7B COX7C COX8A COX8C FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm TBX6 BMP4 LEF1 MAMLD1 CTNNB1 MESP2 DLL3 HES7 MSGN1 RBPJ RIPPLY2 SNW1 EPHA4 PSMD8 PSMD6 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSMD12 NOG PSMD11 PSMD14 PSMD13 WNT3A PSMA7 PSMB6 FGFR1 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 CREBBP MAML2 PSMB1 MAML1 KAT2B KAT2A LFNG EP300 ADRM1 TBXT PSMC5 PSMC6 DLL1 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 MAML3 NOTCH1 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 SEL1L MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 CP MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 RNF185 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS18A MRPS21 MRPS2 MRPL47 MRPL48 MRPS7 DERL1 MRPL45 DERL2 MRPS6 RNF5 MRPL46 MRPS5 OS9 MRPL43 MRPS18C MRPL44 MRPL52 MRPL53 OXA1L MRPL50 ARF4 MRPS9 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS33 MRPL18 MRPS34 MRPL19 MRPL16 MRPS31 EXOC8 EXOC7 MRPL17 MRPL58 MRPL14 MRPL15 MALSU1 MRPS30 MIEF1 EXOC4 MRPL12 EXOC3 MRPL57 EXOC6 MRPL13 EXOC5 MRPL54 EXOC2 MRPL10 EXOC1 MRPL11 MRPL55 MRPL20 GADD45GIP1 PTCD3 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 GBF1 MRPL21 MRPL22 KGD4 RAB11A MRPL30 MTRES1 MTRFR NDUFAB1 POMT2 B3GALNT2 SLC35A4 FKRP CRPPA POMT1 POMGNT2 POMGNT1 B4GAT1 MGAT5B CHST10 POMK DAG1 RXYLT1 LARGE1 LARGE2 FKTN PIAS3 DDB1 UBE2V2 COPS7B XPC COPS7A CUL4A COPS3 COPS6 COPS5 UBE2N COPS8 BDH1 OXCT1 HMGCS2 ACAT1 DCTN6 DCTN5 DCTN1 DCTN4 NR3C2 CAPZA3 CAPZA2 ACTR10 SQSTM1 TFAP2B TFAP2C TWNK UBE2I SUMO1 SSBP1 EIF1AX EIF4H UBE2D2 EIF3M UBE2D3 EIF3K HIF3A EIF3L EIF3I ELOB EIF3J ELOC EIF3G RBX1 EIF3H EIF3E EPAS1 EIF3F CUL2 EIF3C HIF1A EIF3D VHL EIF3A EIF3B GBA1 ACTB DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 TUBA4A CSNK2B XRN2 GAPDHS FKBP9 TP53 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE PDCL GNB4 GNB3 FBXL3 GNB5 EIF5A FBXL5 DHPS WRAP53 FN3KRP TUBA8 GNGT1 EIF5A2 TUBA1C FN3K ICMT TUBA1B GNGT2 DOHH TUBA1A KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A SKIC2 TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 TUBA3E GNA14 AP3M1 TUBA3D GNG3 GNA15 KLK13 TUBA3C GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 TUBB4B TUBB4A RGS11 NUP205 POM121 NUP107 NUP188 AAAS NUP160 POM121C NUP42 NUP85 TPR NUP62 NUP88 NUP43 RAE1 NDC1 RANBP2 SEC13 NUP155 NUP133 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 SLC25A5 SLC25A6 NUP37 CDC20 MT-ND4L PARS2 MRTFA EARS2 LARS2 PPA2 DYNC1LI1 PPA1 TARS2 DYNC1LI2 TARS1 AARS1 AARS2 HARS1 HARS2 CDCA8 EIF5 FARSA FARSB GFM1 TRAM1 GFM2 TCF25 SRP54 FARS2 SSR4 SSR2 SSR3 SRP9 MRRF ZNF598 RPS27 SRP72 SRP68 GARS1 SRP19 MTFMT YARS1 YARS2 EEF1B2 MTRF1 NARS1 NARS2 RARS2 EEF1A2 CARS1 DYNLL1 CARS2 VARS2 RANGAP1 ANKZF1 KLHDC10 DYNLL2 TSFM EIF5B RHOA MARS2 DARS2 INCENP EEF1G BIRC5 SARS2 NEMF EEF1D MTRF1L EEF1A1P5 MTIF2 PRMT3 MTIF3 DYNC1I2 IARS2 WARS1 WARS2 AURKB DYNC1I1 DYNC1H1 TFG GOLGB1 GLUD1 NFKB2 ANK1 SKP1 CCNA2 CCNA1 CUL1 PRKACA ACE2 LAMB2 FN1 LAMB1 LAMC1 RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 EEF1A1 RPS25 B4GALT2 RPS28 B4GALT3 RPS29 RPS20 LRR1 CCNF FAU RPS21 UBE2L6 RPS24 B3GNT7 RPS23 B3GNT4 B3GNT2 HERC2 B4GALT4 FBXO7 FBXO9 WSB1 FBXO2 HLA-B ASCC2 ASCC3 CDC34 SFTPA2 PSME1 FSHB INHBB UBE2J2 INHBA INHA INHBC INHBE SEC31A SIAH1 FBXL8 EIF4EBP1 CALR FBXL4 EIF4E EIF4B LRRC41 GAN RRAGA KLHL2 KLHL3 UBE2G1 UBE2G2 PSMB8 PSMB9 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD7 KBTBD8 SPSB4 FBXO27 LTN1 FBXO21 UBE2Z FBXO22 PDIA3 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RAB7A KLHL42 CUL7 CUL5 UBA6 LMAN1 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H YKT6 KLHL25 UBE2B ZBTB16 KLHL21 KLHL22 BTBD6 UBE2A FBXO30 FBXO31 KLHL20 UBE2W UBA3 UBA1 UBE2K TGFB1 UBE2M TGFBR1 TGFBR2 KBTBD13 SEC61A2 SEC61A1 UBE2Q2 UBE2R2 SEC22B SEC23A ASB13 ASB14 ASB11 ASB12 RNF7 ASB17 ASB18 ASB15 PSMB10 ASB16 FBXL20 ASB10 SEC24B SEC24A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 SEC24D ASB2 ASB3 SEC24C ASB1 GALNT1 CALCA ARFGAP3 ARFGAP2 IAPP MANEA TRAPPC2L LMAN1L TBC1D20 LMAN2L FUT3 SEC31B TRAPPC2 SEC16B TRAPPC3 TPST2 SEC16A KTN1 TPST1 TRAPPC5 TRAPPC9 CNIH1 TMEM115 CNIH2 CNIH3 HSP90B1 MCFD2 MIA2 PPP6R1 CHST8 TRAPPC6A TRAPPC6B SEC22A SEC22C STX17 LMAN2 TRAPPC10 XRCC4 SEC23IP TNC DMP1 FOLR1 BET1 B3GNT3 RPL4 RPL5 RPL30 RAD52 RPL3 RPL32 HSPG2 RPL31 RPLP1 RPL34 RPL10L RPL8 RPL10A MATN3 RPL6 RPL7 RPL7A RPL18A RPL36AL RPL36 RPLP2 RPL35 RPL38 RPL37 PELO RPL39 RPL21 CHD3 RPL23 BMI1 RPL22 RPL13A SUMO3 RPL9P9 SUMO2 RING1 RPL37A PIAS1 RPL24 HDAC4 RPL27 HDAC2 RPL26 L3MBTL2 RPL29 SATB1 RPL28 SATB2 RPL10 RNF2 RPL12 ZBED1 RPL11 RPL36A SUZ12 CBX8 RPL14 PHC2 RPL13 PHC1 RPL15 CBX5 RPL18 CBX4 RPL17 PCGF2 RPL19 CBX2 RPL39L PHC3 RPL41 AMER1 RPL35A RPL23A RPL3L AXIN1 RPL27A RPL22L1 APC ABCE1 RPL26L1 CDC73 RNF152 SHPRH RNF40 RNF144A SKIC8 SELENOS WAC PRKDC CTR9 RTF1 BCL10 TMEM129 HLTF LEO1 PAF1 RNF181 RAD18 RWDD3 UBA2 SAE1 CREBBP AREG NFE2L2 SAA1 TGFA EIF2AK2 MGAT3 APEH HEMK2 ETF1 GSPT2 GSPT1 APOB MME CES1 USO1 TUBB8 RAB2A TUBB8B EIF2B5 EIF2B4 EIF2B3 EIF2B2 RAB1A EIF2B1 RAB1B HGS RAB5A TOP2A GORASP1 STARD7 FDX1 OMA1 OPA1 RPN2 TUSC3 PRKCSH RPN1 MAGT1 ZDHHC2 FUT8 MITF GANAB MAN2A1 MGAT5 MGAT1 MGAT2 OST4 EDEM2 MOGS ARF3 ACHE DDOST MGAT4C HTRA2 TMEM258 DAD1 OSTC MGAT4A CANX MGAT4B STT3A STT3B MAN1B1 LONP1 TRRAP CCP110 BCHE KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 AGT USP17L8 TRIM25 NFRKB USP17L30 YOD1 HCFC1 RNF123 AR RNF128 VDAC3 VDAC2 PIAS4 VDAC1 CFTR GATA3 BRCC3 SNX3 RHOT1 RCE1 ZRANB1 SIAH2 INO80 STAM TADA2B CYLD H2AC25 H2AC21 BAP1 WDR48 OTUD7A OTUD7B RAB4A BABAM1 IFIH1 BABAM2 UCHL1 TRIM4 UIMC1 UFD1 IKBKG TOMM70 RIPK2 ACTL6A JOSD2 UCHL3 JOSD1 ALAS1 UCHL5 DDB2 KAT2B KAT2A PTRH2 PRKN WDR20 NEDD8 USP17L21 USP17L20 USP17L22 RNF135 STAMBPL1 TAF9B USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP9X USP17L19 MCRS1 FOLR2 USP17L10 SFTPC USP17L12 USP17L2 USP17L3 USP17L11 USP17L13 USP17L1 RNF146 OTUD5 TOMM20 YY1 ATXN3L RUVBL1 MAP3K7 RAB14 USP8 USP7 USP5 USP4 USP3 ECI1 USP2 MUL1 H2AC1 CDC25A FKBP8 STAMBP STAM2 INO80C INO80B INO80E VCP INO80D TNKS ADRB2 FOXO4 VCPIP1 ATXN3 ATXN7 NLRP3 RIPK1 SUDS3 CLSPN SMAD2 LHB SMAD1 SMAD4 SMAD3 SMURF2 ESR1 SMAD7 NFKBIA MAVS TADA3 MDM2 MDM4 TAB1 OGT RIGI USP37 STAR USP33 USP34 PTEN TNFAIP3 ARRB1 ARRB2 CEACAM5 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 ACTR5 RAD23A TRAF2 ACTR8 AXIN2 RAD23B H2BC18 TRAF3 TRAF6 BIRC2 OTUB1 BIRC3 USP13 OTUB2 USP14 BECN1 USP15 USP16 VNN2 ABRAXAS1 USP10 USP12 FOXK2 NOD1 FOXK1 ABRAXAS2 MAT2B NOD2 USP18 USP19 TFPT TNKS2 USP24 USP25 USP26 USP20 USP21 RAB32 USP22 RAB35 TAF10 USP28 ASXL1 TNIP1 RAB38 TNIP2 TNIP3 ASXL2 OTUD3 HADH RAB39B RAB8B RAB33A RAB7B RAB21 CHML RAB11B RAB12 RAB13 ARG2 ALPI HNRNPK PIGS PIGU PGAP1 PIGT GPAA1 PIGK OXSM CLPX CLPP FECH ACADSB ALDH18A1 NADK2 ACAD8 CDH2 METTL21A KIN MYO5A METTL22 RAB27A EEF2KMT VCPKMT ETFBKMT MYRIP EEF1AKMT2 EEF1AKMT1 DDX5 FFAR4 GRP U2AF2 GALNT11 GALNT14 GCG GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 GALNT9 GALNT8 B3GNT9 QTGAL B3GNT8 B3GNT6 CHST4 GCNT1 GCNT3 GCNT4 GCNT7 GALNT7 GALNT6 GALNT5 GALNT4 A4GNT GALNTL5 GALNTL6 P2RY2 ADRA2C COL7A1 ADRA2A MDC1 MT-CO1 B4GALT1 DTL MT-CO2 MT-CO3 GATA4 PSMD9 PSMD4 PSMD5 PPARGC1A PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 FOXL2 HIC1 SP3 ALDH2 PPARG PPARA LY6E MT-ND6 MT-ND4 MT-ND5 MT-ND2 MT-ND3 MT-ND1 BGLAP SPP1 SUCLG2 UQCRC2 OGDH MT-ATP6 RORA FH DLST ATP5PF ATP5PD MDH2 ATP5F1C MT-ATP8 ATP5PO NDUFA13 SOCS3 NDUFV3 ATP5MG NDUFV1 IDH2 UQCRQ MT-CYB ETFB ME2 IDH3A FBXO32 SFTPB SFTA3 SFTPA1 NDUFS1 NDUFB6 COX4I1 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 RABGGTB ADGRF5 RABGGTA NDUFA2 GALNT12 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTS4 ADAMTSL1 ADAMTS5 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTS1 ADAMTSL3 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS8 ADAMTS9 ADAMTS6 ADAMTS7 SBSPON MUCL1 MUC3A MUC5AC MUC3B ADAMTS20 B3GLCT CFP TRIM28 THBS2 ADAMTS12 THSD1 THSD4 ADAMTS10 ADAMTS16 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS18 ADAMTS17 MUC7 MUC4 MUC6 MUC16 GALNT3 MUC17 C1GALT1 MUC19 SSPOP MUC5B MUC20 MUC21 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 EEF2 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 EDEM1 AMFR SYVN1 RNF103 TRIM13 ENGASE NR5A1 PCNA COX5B COX5A RELA NPM1 NR3C1 NPPA KLK3 SP100 KLK2 RAB9A RAB9B KIF5B KIF5A VDR IL6 PCSK2 ERO1B CPA3 CDX2 LEP ENPEP CPB1 SENP5 CLTRN SENP2 NOP58 TRIAP1 ACE CPE REN CSF1 C4A LGALS1 SMC5 SMC6 EVA1A CCN1 NSMCE3 NSMCE2 CHGB NSMCE1 IGFBP5 NSMCE4A IGFBP4 EID3 IGFBP2 SHISA5 PDIA6 PAPPA MXRA8 SPARCL1 IGFALS AURKA SCG2 KLK1 TGOLN2 STC2 PENK IGFBP7 IGFBP6 AMELX WFS1 AMBN TMEM132A ZNF131 FUCA2 UHRF2 DDX17 HRC CASP8AP2 MELTF MBD1 SERPINA10 SAFB MIA3 MSLN TOPORS PRSS23 CHRDL1 BMP15 MMP1 MMP2 MEPE DNAJC3 B4GALNT2 RCN1 VGF ENAM AMTN VWA1 FAM20C FAM20A MFGE8 PAPPA2 ITIH2 SERPINC1 AFP FSTL1 FSTL3 CST3 APOL1 TOP2B TOP1 SERPIND1 GOLM1 POFUT2 GZMH NUCB1 NOTUM POFUT4 POFUT3 EMID1 MMRN2 LYPD1 CGA LYPD2 LYPD3 THY1 LYPD4 LYPD5 PRELID1 LYPD8 LYPD6B PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX CPB2 LRRC49 PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH TTLL7 TTLL6 TTLL5 TTLL4 TTLL3 TTLL2 CHM TTLL1 TTLL9 TTLL8 LY6K AGTPBP1 LY6D LY6H ING2 SPRN SPACA4 NICN1 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 RAB22A CD59 CD52 CD55 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 RAB40A ZNF350 RAB40B RAB40C TPGS1 TPGS2 GCSH GPLD1 LIPT2 LIPT1 RAB3A GP2 ASGR1 PRSS21 ASGR2 AGBL5 PRSS41 AGBL4 AGBL1 AGBL3 AGBL2 RAB3B RAB3C RAB42 TECTA HIPK2 TECTB RAB2B VASH2 VASH1 RAB34 PLET1 CPM PSCA RTN4RL2 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 RAB29 RAB15 RAB19 RAB17 TTLL10 NFU1 TTLL13 MEN1 TTLL11 TTLL12 IGFBP1 UMOD LIAS OTOA RAET1G RAET1L IGFBP3 IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM ULBP2 PGR OPCML NEGR1 XPNPEP2 FUCA1 WDR5 RAB3D RAB44 RAB31 RAB37 RAB5B RAB5C HDAC7 RAB6A TRAPPC1 RBBP5 RAB4B RBBP7 FCGR3B KLF4 PML MSRA PCMT1 MSRB2 MSRB3 MSRB1 TTR RAB24 RAB10 TSPAN14 RAB18 ANPEP TXN COMMD9 PARP1 BST1 VNN1 CTSZ CTSH CTSC COMMD3 KCTD6 NR4A2 SRP14 THRB CGB8 COPB1 NR2C1 THBS1 HSPD1 ADA2 POMC ATP6AP2 FGA PLAUR FGG CAND1 F7 F9 PROC F10 GGCX PROS1 PROZ F2 GAS6 DBT DLD PCSK9 APOA2 APOA1 APOA4 APOA5 SAR1B GPIHBP1 MBTPS1 ALB P4HB BTRC ADAMTS13 MTA1 HSD17B10 EPRS1 TRMT112 SOCS2 SOCS6 IKBKE CETN2 ACTR1A CSNK1D DCTN2 DCTN3 JMJD6 RIOX2 ANO8 RNF168 ANKRD28 ASPH PPP6C PPP6R3 TP53BP1 COP1 SMC1A SMC3 STAG1 STAG2 RAD21 TDG DCAF13 PRL CALB1 NAT8B BACE1 APCS TSPAN33 GGA2 GGA1 GGA3 TSPAN5 SNCA H2AZ1 ODAM SNCAIP SORL1 TSPAN15 NAT8 TGFBI ITM2B CSF2RB CSF2RA NCOA2 PNPLA2 TTF1 CTBP1 DNMT1 DNMT3B DNMT3A SLC30A8 SLC30A5 STS ARSA SUMF2 SUMF1 B3GNT5 B4GALT6 B4GALT5 ARSL ARSJ ARSK ARSH ARSI ARSF ARSG ARSD SFTPD TUFM UBE2L3 RARS1 SPTAN1 LARS1 AIMP1 AIMP2 QARS1 MARS1 DARS1 SARS1 EEF1E1 GSN KARS1 IARS1 UBE2T OTULIN ALDH1B1 APH1A PSENEN NCSTN APH1B ADAM10 FBXL18 FBXL7 SDC2 TMED2 GPC3 ADORA2A UCN MBOAT4 PLA2G7 CRHR2 GH1 DCAF8 DCAF5 DCAF4 DCAF6 WSB2 OBSL1 DCUN1D5 TSHB DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF1 NPLOC4 DDA1 RPLP0 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 SPSB3 CCDC8 CISH CUL9 DPP3 HSPA9 UBD NAE1 SOCS5 WDTC1 CCDC22 COMMD10 TULP4 DCAF16 DCAF17 FEM1C DCAF10 DCAF11 FEM1A FEM1B CAPZA1 NEURL2 ERCC8 PSME2 GOSR2 SSR1 ARFGAP1 SRPRA SRPRB PREB KDELR3 PCCB PCSK1 GPR119 PAX6 ISL1 GIP DPP4 SPCS3 SPCS2 SPCS1 FFAR1 RWDD1 SEC11A JMJD4 KDM8 SEC11C JMJD7 RIOX1 OGFOD1 DRG1 DRG2 RCCD1 ZC3H15 ADORA2B SHMT2 STX5 CMA1 IDE CAPZB GATA6 CTSD TFAM SCFD1 SPTBN1 PARK7 MUC13 INS FGF23 ABCA3 GRIA1 CKAP4 SENP1 CALM1 NDUFS3 UBE2C UBE2E1 UBE2D1 PDHB UBE2S CDK1 DLAT BLM PDK1 BRCA1 PDHA1 WRN BARD1 FBXW11 RPA1 RAB8A PALB2 SEM1 APP APLP2 CD109 KDELR1 SCG3 RAB43 RAB41 KIF5C KNG1 COG8 COG7 COG6 COG5 IGF2 COG4 RAB27B COG3 CTSG IGF1 COG2 COG1 RAB30 RAB36 TF KDELR2 CALU COPB2 COPA TMED10 MAN2A2 SERPINA1 RAB6B RAB39A COPE QSOX1 TIMP1 AHSG LTF MAN1A2 F5 TMED3 F8 MMRN1 MAN1A1 TMED7 PLG TMED9 COPZ2 SPP2 BET1L COPZ1 RAB33B ARF5 NAPA NAPB GOSR1 NAPG GOLGA2 LYZ BPIFB2 MAN1C1 SEMG1 SPG7 GALNT2 AFG3L2 ARCN1 SMDT1 YME1L1 PMPCA MICU2 COPG2 COPG1 LTBP1 TCF7L2 BMP4 CDKN1A HDAC1 CDKN2A FBN1 SIN3A CHCHD2 CTNNB1 EIF2S2 EIF2S1 EIF2S3 ECH1 SPTB ACOT2 STX1A MYC LDHD ANK2 PSMD8 ANK3 PSMD6 PSMD7 SPTBN4 SPTBN5 PSMD2 PSMD3 SPTBN2 PSMD1 NUP214 CS PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 ACO2 PABPC1 UBA52 PSMD12 SEC61G PSMD11 TIMM17A PSMD14 SEC61B PSMD13 SPTA1 PSMA7 PSMB6 PSMB7 PEX2 PSMB4 TIMM22 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A HSPA8 VAMP2 ADRM1 PSMC5 PSMC6 TIMM9 PSMC3 PSMC4 PSMC1 PSMC2 TIMM10 EIF4G1 ATP5F1A ATP5F1B PEX10 PEX12 SRD5A3 C3 PEX13 PEX14 FURIN IL33 RNF20 CCT2 GPS1 CUL3 COPS4 COPS2 TRAPPC4 HNRNPC CCT7 B2M HLA-A VCAN GLB1 ARSB TRIM27 SKP2 DAXX CAMKMT CCNE2 CCNE1 H2AX H2AB1 H2AC19 H2BC26 H2AC14 H2BC12L H2BC21 EP300 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 EIF4A2 H2BC12 H2BC13 EIF4A1 H2BC14 H2BC15 H2BC11 RARA H3C15 RXRA H2BC9 H4C9 H2BC8 H2BC5 H2BC3 STAT3 H2BC1 H2AC20 HDAC3 KDM1B GNAT3 NSF NRIP1 APOE NCOA1 NR1H2 NCOR2 DPAGT1 ST6GALNAC1 CMAS ST6GALNAC2 MPI HK1 GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ALG8 ST6GAL1 ST6GAL2 ALG9 ALG6 ALG5 SLC35C1 ALG14 ALG2 ALG3 ALG13 ALG12 ALG11 ALG1 ALG10 RENBP DHDDS DPM1 DPM2 DPM3 RFT1 MVD ST6GALNAC3 ALG10B ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 GNE UAP1 NPL FUOM NEU2 NEU3 NEU4 DHRSX GMDS AMDHD2 NEU1 ST3GAL4 ST8SIA4 SLC17A5 ST8SIA5 ST3GAL5 ST8SIA6 ST3GAL6 ST3GAL1 ST3GAL2 FBXL21P ST3GAL3 MPDU1 CTSA NUS1 SLC35A1 PMM1 ST8SIA1 ST8SIA2 GFPT2 PMM2 ST8SIA3 GFPT1 DOLK NAGK FCSK DOLPP1 SLC34A2 MRPS17 SLC34A1 MRPS15 MRPS16 MRPS14 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 95%1170546 Prolactin receptor signaling PRL PRLR STAT5A STAT5B CSH1 GH2 GHR BTRC JAK2 SKP1 RBX1 CUL1 PTPN11 GH1 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 ALOX15B PTGS2 ALOX15 GPX2 GPX1 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 95%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants IQGAP1 NRAS FN1 MAPK1 PHB1 RAP1B MAP3K11 ARAF RAP1A PEBP1 CSK RAF1 JAK2 MARK3 FGB BRAP FGA VWF MAPK3 KSR1 KRAS FGG BRAF KSR2 CNKSR2 APBB1IP CNKSR1 TLN1 VCL CAMK2B CAMK2D SRC YWHAB CAMK2A HRAS ARRB1 ARRB2 MAP2K1 MAP2K2 ITGB3 ITGA2B CALM1 CAMK2G DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 95%1474228 Degradation of the extracellular matrix MMP15 COL18A1 MMP17 MMP19 TMPRSS6 NID1 FURIN CAPN8 SPP1 CAPN9 CAPN6 CAPN7 CAPN5 CAPN3 ADAM15 ADAM9 CTSG HTRA1 SCUBE3 PRSS2 SCUBE1 BMP1 KLK2 MMP25 A2M TIMP2 ADAM17 SPOCK3 CAPN13 TIMP1 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 DCN TLL1 BCAN PLG LAMA5 LAMB3 CMA1 ELANE LAMA3 ADAM8 LAMB1 LAMC2 LAMC1 CAPNS1 CAPNS2 CAPN2 CAPN1 CAST MMP1 MMP2 CTSD MMP3 COL17A1 COL15A1 COL16A1 COL13A1 COL14A1 COL12A1 COL19A1 COL26A1 COL25A1 NCSTN COL23A1 HSPG2 ADAM10 PSEN1 ACAN COL9A1 CD44 COL9A3 COL9A2 CDH1 CTSS ADAMTS4 ADAMTS5 ADAMTS1 ADAMTS8 ADAMTS9 KLKB1 ADAMTS16 ADAMTS18 MMP8 MMP9 PRSS1 PHYKPL CTRB2 CTRB1 OPTC KLK7 CTSB BSG CTSV MMP20 MMP24 CTSL TPSAB1 MMP7 MMP13 CTSK MMP10 MMP12 MMP11 MMP14 CASP3 MMP16 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT5A STAT5B STAT3 IL22 JAK3 STAT4 JAK2 IL20RA IL20RB IL22RA2 JAK1 STAT1 IL22RA1 IL10RB PTPN11 TYK2 IFNLR1 IL20 STAT2 IL26 IL24 IL19 IFNL2 IFNL1 IFNL3 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-HSA-9006925.5 Intracellular signaling by second messengers JUN ADCY9 NTRK3 NTF3 ADCY4 ADCY3 PDGFB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG PRKACA PRKACB PDE1B PDE1A ITPR1 IRAK1 ITPR2 ITPR3 PRR5 CHD4 GSK3A RCOR1 EED MTA2 MTA1 REST MTA3 PIP4K2A PIP4K2B PIP4K2C PRKAR1B PRKAR2B PDGFRA PRKAR1A RAC1 PRKAR2A PRKX KIT VAV1 MAPKAP1 HBEGF CDKN1A HDAC1 PIP5K1A PIP5K1B MET BAD ATF2 CD19 EGR1 RPTOR MYD88 TNRC6C MOV10 MLST8 SLC38A9 AGO3 AGO4 AGO1 AGO2 TSC2 TNRC6A TNRC6B MTOR PSMD8 RRAGA PSMD6 RRAGC PSMD7 RHEB RRAGB PSMD2 RRAGD AKT1S1 PSMD3 LAMTOR2 AKT1 LAMTOR1 PSMD1 LAMTOR4 LAMTOR3 LAMTOR5 PRKCD PRKCA PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PIK3CG PIK3R6 UBA52 PIK3R5 PSMD12 PSMD11 PSMD14 PSMD13 EZH2 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 RPS27A PIK3CD ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 AHCYL1 PSMC4 PDE1C PSMC1 CSNK2B CAMKK1 PSMC2 CAMKK2 GRK2 KPNA2 PRKCG TP53 PRKCE NBEA CASP9 PPARG XIAP RNF146 USP7 IL1RL1 IL33 RICTOR MBD3 TNKS FOXO4 GATAD2B GATAD2A ESR1 MDM2 CD28 PREX2 PTEN SNAI2 TRIM27 WWP2 NEDD4 MKRN1 EGF FRK EGFR HDAC5 TRAF6 PLCG1 CDKN1B USP13 HDAC7 RBBP4 RBBP7 KLB FLT3 IRS1 PPP2R1B PPP2R1A IRS2 PIK3CB TNKS2 PML FGF1 FGF2 FGF3 FGF4 FOXO6 FGF6 FOXO1 FGF7 FGF9 AKT2 OTUD3 PDPK1 GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 TRIB3 PPP2R5E PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS SGK1 FGF20 THEM4 HDAC3 KDM1A MAPK1 FGF23 FGF22 CHUK MAPK3 INSR PTPN11 FGF16 FGF19 PPP2CA FGF18 PPP2CB FGFR4 FGF10 CHD3 BMI1 CBX6 RING1 CAMK2B ESR2 CAMK2D HDAC2 SRC NR4A1 CAMK2A NRG1 RNF2 SUZ12 CBX8 PHC2 PHC1 NR2E1 CBX4 CBX2 PIK3AP1 PHC3 CALM1 GSK3B CAMK2G IER3 MECOM PHLPP2 STUB1 PHLPP1 CD86 CD80 ATN1 SALL4 ERBB2 MAF1 TRAT1 RPS6KB2 SNAI1 STRN IRAK4 AREG SEM1 LCK CAMK4 FYN NTF4 PDGFRB NTRK2 BDNF TGFA FOXO3 HGF EREG BTC EPGN AKT3 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 95%421270 Cell-cell junction organization ZNF217 STRAP HEYL ANGPTL4 PATJ CRB3 TCF3 TGIF2 EED POMT2 POMT1 PRKCI RACK1 RPN2 PRKCSH HDAC1 RPN1 GANAB CTNNB1 OST4 DNM2 MOGS DDOST TMEM258 DAD1 OSTC CANX TNRC6C MOV10 MYCN STT3A AGO3 TFAP2A AGO4 CDH1 MYC CTSS AGO1 AGO2 TNRC6A TNRC6B CLDN5 PSMD8 ANK3 PSMD6 PSMD7 TCF12 PSMD2 PSMD3 PSMD1 PSMA5 PIP5K1C PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PARD6G CLDN2 EZH2 PSMA7 CLDN1 CLDN22 PSMB6 CLDN20 CLDN23 PSMB7 CLDN11 CLDN6 PSMB4 CLDN10 CLDN4 PSMB5 CLDN3 CLDN15 UBB CLDN9 PSMB2 CLDN14 PSMB3 CLDN8 CLDN7 UBC CLDN12 PSMB1 CLDN19 ANG CLDN18 RPS27A CLDN17 CLDN16 ADRM1 CSNK2A1 PSMC5 CSNK2A2 PSMC6 PSMC3 PSMC4 PSMC1 CSNK2B PSMC2 SIRT1 CTSB ARHGAP32 FURIN PCSK6 TLE1 SPCS3 SPCS2 SPCS1 SEC11A SEC11C SDK1 SDK2 MDM2 FOXQ1 PALS1 CBLL1 ZMYM2 DNTTIP1 ZBTB33 FOXP2 MCRIP1 FOXJ2 KLF9 SNAI2 FOXA2 KMT5A JUP RB1 RBBP4 RBBP7 H2AX KLF4 H2AB1 H2AC19 H2BC26 H2AC14 PKM H2BC12L H2BC21 PARD6A H3-3B F11R H3C8 H2AC8 PARD6B PARD3 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 TWIST2 TWIST1 H2BC11 BANP H3C15 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 KDM1A MAPK1 MAPK3 HDAC2 SRC SUZ12 ARID1A PRDM8 CTNND1 BHLHE22 CDH8 ZC3H12A CTNNA1 CDH24 HOXC8 FOXF1 CSNK2A3 ADAM33 PVR SOX10 PCSK7 ADAM19 MPHOSPH8 ILF3 ZEB2 CDH11 SNAI1 CDH19 CTBP2 CTBP1 SP1 CDH5 CDH2 VCL MTBP CDH4 EPS15 WT1 NECTIN2 CADM3 CADM1 CADM2 ZEB1 CDH9 CDH15 CDH7 SEM1 CDH6 SMARCA4 CDH3 CDH10 CDH12 CDH13 CDH17 CDH18 NECTIN4 NECTIN3 CTSL NECTIN1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-HSA-5693537.3 Resolution of D-Loop Structures MUS81 FIRRM BLM SLX4 RTEL1 MRE11 EME1 BRCA1 EME2 BRCA2 GEN1 RAD51AP1 SLX1B WRN SPIDR BRIP1 KAT5 EXO1 RBBP8 NBN BARD1 RMI2 RMI1 XRCC2 TOP3A XRCC3 PALB2 RAD51B SEM1 RAD50 RAD51D RAD51 RAD51C ATM DNA2 FIGNL1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 95%5609975 Diseases associated with glycosylation precursor biosynthesis SRD5A3 PGM1 GALM DHDDS DPM1 NUS1 DPM2 DPM3 GALK1 MPI GALE PMM2 GFPT1 DOLK GNE GALT POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C AGO3 AGO4 AGO1 AGO2 TNRC6A TNRC6B DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 95%418597 G alpha (z) signalling events PRKCA GNG13 GNB2 GNB1 GNAS ADCY9 GNB4 GNB3 ADCY4 ADCY3 GNB5 ADCY2 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 GNAT3 ADRA2C RGS4 ADRA2B RGSL1 ADRA2A GNAZ GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCB GNAI3 RGS20 PRKCH RGS17 GNAI1 RGS19 PRKCG PRKCQ GNAI2 PRKCE RGS16 GNG10 GNG12 PRKCD GNG11 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G2D PLA2G2E PLA2G3 PLA2G5 PLA2R1 PLA2G10 LPGAT1 PLA2G4F PLA2G12A PLA2G4D PLA2G4B PLA2G2A PLA2G1B LPCAT4 CRLS1 PLA2G2F LPCAT1 PLA2G4A PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 95%9005895 Pervasive developmental disorders CAMK4 GPS2 NCOR2 SIN3A PRKACA NCOR1 TBL1XR1 TBL1X HDAC1 CALM1 HDAC3 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME DATABASE ID RELEASE 95%416572 Sema4D induced cell migration and growth-cone collapse PLXNB1 ERBB2 RHOC SEMA4D RHOA LIMK2 RHOB LIMK1 ROCK1 MYL12B ROCK2 MYL6 ARHGEF11 MYH9 MYH14 ARHGEF12 MYH11 RND1 MYH10 MYL9 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network NTRK3 NTF3 PDGFB IL1RL1 IL33 IRAK1 ESR1 CD28 PTEN EGF EGFR TRAF6 KLB FLT3 IRS1 PPP2R1B IRS2 PPP2R1A PIK3CB FGF1 FGF2 FGF3 FGF4 PIP4K2A FGF6 PIP4K2B FGF7 PIP4K2C FGF9 AKT2 PDGFRA RAC1 KIT GAB1 FLT3LG FRS2 GAB2 PIK3R3 NRG3 PIK3CA NRG4 NRG2 VAV1 TRIB3 PPP2R5E HBEGF PPP2R5B RAC2 PPP2R5A PPP2R5D RHOG PPP2R5C PIK3R2 PIK3R1 INS FGF20 PIP5K1A THEM4 PIP5K1B MAPK1 FGF23 FGF22 MET MAPK3 INSR PTPN11 CD19 FGF16 FGF19 FGF18 PPP2CA FGFR4 MYD88 PPP2CB FGF10 ESR2 SRC NRG1 AKT1 PIK3AP1 IER3 PHLPP2 PIP5K1C PHLPP1 CD86 CD80 ERBB2 PIK3CG TRAT1 PIK3R6 PIK3R5 STRN IRAK4 PIK3CD AREG LCK FYN PDGFRB NTF4 NTRK2 BDNF TGFA HGF EREG BTC EPGN AKT3 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 95%9024909 BDNF activates NTRK2 (TRKB) signaling NTRK2 BDNF FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.8 Fructose metabolism ALDOB GLYCTK SORD KHK ALDH1A1 TKFC AKR1B1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 95%9630750 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME%R-HSA-9956529.1 ASL variants cause argininosuccinate aciduria ASL KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF28P KIF22 KIF6 KIF27 KIF9 KIFC2 KIFC1 KIF5C KIF21A KIF21B KLC1 KIFAP3 KLC4 KIF2A KLC3 KLC2 KIF2C KIF2B KIF16B KIF3A KIF20B KIF3B KIF3C KIF5B KIF5A KIF18B KIF26A KIF4B KIF26B KIF4A KIF12 CENPE KIF11 KIF23 RACGAP1 KIF15 KIF19 KIF13B KIF1C KIF1B KIF18A KIF20A KIF1A KIF25 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 95%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes CREBBP PRDX1 ATF4 MAFK SLC7A11 GCLC NFE2L2 EP300 GCLM NQO1 GSTA3 GSTA1 SRXN1 CHD6 HMOX1 TXN SOD3 BACH1 TXNRD1 SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.4 Signaling by FGFR1 in disease SOS1 CEP43 BAG4 STAT5A STAT5B STAT3 PIK3R1 ERLIN2 NRAS TRIM24 PLCG1 FGF20 FGF23 CPSF6 FGFR1 MYO18A LRRFIP1 STAT1 CUX1 BCR FGF1 FGF2 FGF4 FGF6 FGF9 HRAS ZMYM2 GAB1 FGFR1OP2 FRS2 GAB2 PIK3CA SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC PHOSPHO1 CHPT1 ABHD3 PCYT1B PCYT1A CHAT CHKB CHKA STARD10 MFSD2A ACHE LPCAT1 PCTP LPIN1 LPIN2 LPIN3 CSNK2A1 CSNK2A2 CEPT1 BCHE CSNK2B STARD7 PEMT SLC44A5 SLC44A3 SLC44A4 SLC44A1 SLC44A2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 95%9918442 Defective visual phototransduction due to LRAT loss of function RBP1 LRAT PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 95%5654221 Phospholipase C-mediated cascade; FGFR2 FGF18 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PLCG1 FGF20 FGF23 FGF22 FGF16 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9955542 CPS1 variants cause CPS1 deficiency CPS1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNG13 GNB2 KCNJ2 KCNJ3 GNB1 KCNJ4 GNB4 GABBR2 GNB3 KCNJ5 GNB5 KCNJ6 GABBR1 KCNJ10 GNGT1 KCNJ12 KCNJ9 GNGT2 KCNJ15 KCNJ16 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 GNG10 GNG12 GNG11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 95%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript SRSF6 SRSF7 MAGOH SRSF9 RBM8A CDC40 DDX39A ZC3H11A SARNP CHTOP ALYREF DDX39B SRRM1 DHX38 NXF2B NXT1 UPF3B MAGOHB RNPS1 NUP205 POM121 NUP107 NUP188 LUZP4 POLDIP3 AAAS NUP214 SRSF1 NUP160 POM121C NUP42 NUP85 SLU7 TPR NUP62 U2AF1 FYTTD1 U2AF1L4 NXF1 NUP88 NUP43 RAE1 NDC1 U2AF2 RANBP2 SEC13 NUP155 NUP133 SRSF11 NUP210 NUP153 NUP93 NUP50 NUP35 NUP54 NUP37 CASC3 NCBP1 NCBP2 THOC1 THOC3 THOC2 THOC5 THOC7 THOC6 SRSF2 SRSF3 EIF4A3 SRSF4 GLE1 SRSF5 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 95%9766229 Degradation of CDH1 RACK1 CTNNB1 DNM2 CDH1 CTSS SRC MDM2 PSMD8 PSMD6 CBLL1 PSMD7 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 JUP CTNND1 UBA52 PSMD12 PSMD11 CTNNA1 PSMD14 PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 UBB PSMB2 PSMB3 UBC PSMB1 MTBP RPS27A EPS15 ADRM1 PSMC5 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 CTSB CTSL BANP DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%3371598 Defective BTD causes biotidinase deficiency BTD LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 95%9658195 Leishmania infection JUN FZD7 WNT5A RELA ADCY9 ADCY4 ARPC1B ADCY3 ARPC1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACG ARPC4 ARPC5 IGHV3-23 PRKACA CTSG ARPC2 PRKACB ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 CYSLTR1 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 GGT5 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 ITPR1 IGHV7-81 ITPR2 NCKIPSD GGT1 ITPR3 IGKV2D-30 IGHV4-59 IGHV1-69 IL6 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 PLCG2 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 P2RX7 IGLV7-43 IGKV1D-16 IGKV1D-12 P2RX4 IGLV1-51 IGLV2-23 CRK IGKV3-20 GNAS IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 GSDMD IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IL18 IGLV3-19 IL1A IGHV2-70 IL1B CYSLTR2 IGHV2-5 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 IGLC7 MYO10 IGHV3-53 MYO1C IGKV5-2 IGLC6 IGKV1-5 PRKAR1B PRKAR2B PRKAR1A RAC1 PRKAR2A VAV3 PRKX MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 C3AR1 V2-11 V3-4 V3-3 V2-17 PLK2 HSP90AB1 V3-2 V2-15 V2-19 V1-11 V1-16 V1-13 MAPK8 V2-8 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 TXNIP HMOX1 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 BRK1 LYN BTK CYBA IL10 ACTB NOXO1 MAPK14 AHCYL1 MEFV PSTPIP1 NT5E ENTPD1 ENTPD5 NCKAP1L WASF1 SUGT1 GNG10 WASF2 GNG12 GNG11 GNG13 GNB2 BAIAP2 C3 GNB1 ABI2 GNB4 FURIN NOXA1 GNB3 ABI1 GNB5 ABL1 NOX1 GNGT1 GNGT2 NLRP3 GNAZ CD163 RHBDF2 ADORA2B GNG3 GNG2 ADAM17 GNG5 WIPF1 GNG4 WIPF2 GNG7 CYFIP2 WIPF3 GNG8 ELMO1 FCGR1A PYCARD PLCG1 WASL ACTG1 NCK1 WAS WASF3 FCGR2A DVL1 MYO9B DVL2 DVL3 TXN DPEP2 NFKB1 DPEP1 MAPK1 GNAT3 ELMO2 MAPK3 CDC42 GNAI3 GNAI1 GNAI2 CASP1 CALM1 DOCK1 NFKB2 MYO5A YES1 HCK SYK FYN PTK2 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs RHOC PPP1R12A RHOA LIMK2 RHOB PAK1 LIMK1 ROCK1 MYL12B ROCK2 MYL6 MYH9 CFL1 MYH14 MYH11 MYH10 MYL9 PPP1R12B PPP1CB DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.4 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) UBC TICAM2 TICAM1 RPS27A TBK1 IRF3 TRAF3 OPTN LY96 UBA52 CD14 IKBKE IRF7 TANK PTPN11 UBB TLR4 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription HES1 HDAC5 CCNC HDAC1 UBA52 HES5 TLE4 HDAC3 HDAC8 TLE2 HDAC9 TLE1 HDAC6 HDAC7 HEYL MAMLD1 TBL1X UBB RBPJ CREBBP UBC CDK8 MAML2 NCOR2 MAML1 RPS27A HEY1 KAT2B NCOR1 KAT2A TBL1XR1 HDAC10 EP300 SNW1 HDAC11 MYC HEY2 HDAC4 HDAC2 SKP1 RBX1 MAML3 NBEA HIF1A NOTCH1 CUL1 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 95%3214841 PKMTs methylate histone lysines NSD2 KMT5C SUV39H1 MECOM H4C9 RELA EED SMYD3 NFKB1 ATF7IP SETD1B SETD1A AEBP2 RBBP4 NFKB2 EZH2 RBBP5 PRDM16 RBBP7 KMT2D PRDM9 EHMT2 EHMT1 ASH2L KMT2C KMT2B SETDB2 SUV39H2 SETD2 SETD3 SETD6 SETD7 H3C8 ASH1L DOT1L SMYD2 NSD3 SUZ12 NSD1 DPY30 SETDB1 WDR5 KMT2A KMT5A H3C15 KMT5B METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 95%1237112 Methionine salvage pathway GOT1 MRI1 MTAP APIP ENOPH1 ADI1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes JUN PMS2 MLH1 CDK12 CDK13 FANCI MDC1 ATF2 FANCC FANCD2 CCNT2 ELOB ELOC CCNH POLR2A POLR2B POLR2C POLR2D CCNK POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L MSH2 GTF2H1 GTF2H2 GTF2H3 SUPT5H GTF2F1 BRCA1 GTF2H4 GTF2F2 CTDP1 GTF2H5 ELL CDK7 CCNT1 ERCC3 SUPT4H1 ERCC2 ELOA MNAT1 CHEK1 NELFB NELFCD NELFA NELFE SUPT16H ELOA2 SSRP1 DDB2 CDK9 TCEA1 RAD51D FOS TP53 ATM ATR FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4Y2 RPS27L RPS4Y1 RPS4X RPS15 RPS14 RPS17 RPS15A RPS16 RPS19 RPS18 RPS3 RPS2 RPS27A RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS26 RPS25 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS27 RPS23 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 95%140875 Common Pathway of Fibrin Clot Formation SERPINA5 CD177 THBD F13B PRTN3 SERPINC1 F13A1 PROC F10 SERPIND1 F5 FGB PROS1 F8 PF4V1 FGA F2 SERPINE2 FGG PF4 F2R PROCR RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB8B RAB43 RAB14 RAB41 RAB33A RAB7B RAB21 RAB27B CHML RAB11B RAB12 RAB30 RAB13 RAB36 CHM RABGGTB RABGGTA RAB9A RAB6B RAB9B RAB39A RAB22A RAB3D RAB40A RAB40B RAB44 RAB40C RAB3A RAB33B RAB31 RAB2A RAB37 RAB5B RAB5C RAB3B RAB3C RAB42 RAB11A RAB6A RAB1A RAB2B RAB1B RAB4A RAB4B RAB34 RAB5A PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB7A RAB29 RAB32 RAB15 RAB35 RAB19 RAB17 RAB27A RAB38 RAB24 RAB8A RAB10 RAB18 RAB39B 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 95%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC2 MCCC1 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP4F3 CYP4A22 CYP4B1 CYP2U1 CYP2S1 CYP4F2 CYP2W1 CYP2D6 CYP4A11 CYP3A43 CYP4F22 CYP4F11 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME DATABASE ID RELEASE 95%9026286 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX15 ALOX5 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 95%9013406 RHOQ GTPase cycle ARHGEF9 ARHGAP26 OBSCN MPP7 VANGL1 ARHGAP32 ARHGEF7 ARL13B RHOQ TRIP10 CDC42 CPNE8 STEAP3 GJA1 FNBP1 SCRIB GFOD1 LAMTOR1 IQGAP1 TFRC IQGAP3 SNAP23 CFTR ARHGAP1 WWP2 SLC4A7 ARHGAP5 JUP ARHGAP35 GOPC SYDE1 ARHGAP33 OPHN1 GIT1 WASL PLEKHG3 DEPDC1B CDC42EP1 VAMP3 RAB7A CDC42EP4 CDC42EP3 CDC42EP2 ITSN1 ARHGAP17 SLC1A5 ARHGAP21 PREX1 STOM PAK1 CDC42BPB SRGAP2 CDC42BPA PAK2 DLC1 PAK4 DIAPH3 GIT2 CAV1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 95%2428924 IGF1R signaling cascade SOS1 PIK3R4 PIK3R2 PIK3R1 NRAS FGF20 THEM4 FGF23 IGF2 FGF22 IGF1 KLB FLT3 IRS1 PDE3B PTPN11 IRS2 FGF16 PIK3CB FGF19 FGF18 FGFR4 FGF1 FGF10 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 AKT2 HRAS PDPK1 GAB1 IRS4 FLT3LG IGF1R FRS2 GAB2 PIK3CA TLR9 PIK3C3 TRIB3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.9 tRNA modification in the nucleus and cytosol TRIT1 ADAT2 TRMT6 TYW5 TRMT61A TYW3 TRMT5 TYW2 TYW1 LCMT2 ALKBH8 THG1L TRMT44 PUS3 METTL1 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B EPRS1 TRMT13 TRMT11 QNG1 TP53RK WDR4 TRMT112 NSUN2 NSUN6 DUS2 QTRT1 GON7 QTRT2 CTU2 CTU1 URM1 LAGE3 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME%R-HSA-380994.5 ATF4 activates genes in response to endoplasmic reticulum stress CXCL8 DCP2 NFYA PARN NFYB NFYC ATF6 EXOSC7 CEBPB EXOSC6 CEBPG HERPUD1 CCL2 EXOSC5 ASNS EXOSC4 DDIT3 EXOSC9 ATF3 ATF4 EXOSC8 EXOSC3 EXOSC2 EXOSC1 IGFBP1 KHSRP DIS3 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome HBEGF PXN AREG EGF PIK3R1 EGFR SRC CSK TGFA GAB1 EREG PIK3CA BTC PTPN11 EPGN PAG1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 95%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling SKP1 RBX1 NOTCH1 CUL1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 95%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A3 SLC22A1 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNG13 GNB2 GNB1 GNG3 GNB4 GNB3 GNG2 GNG5 GNB5 GNG4 GNG7 GNGT1 GNG8 GNGT2 PLCB3 PLCB1 GNG10 PLCB2 GNG12 GNG11 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 95%69615 G1 S DNA Damage Checkpoints PLK3 CDKN1A CDKN2A CDC25A CDK2 PHF20 MDM2 MDM4 PSMD8 PSMD6 PSMD7 PSMD2 RBX1 PSMD3 PSMD1 GSK3B CSNK1A1 ZNF385A PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 UBA52 PSMD12 CDKN1B PSMD11 PSMD14 BTRC PSMD13 PSMA7 PSMB6 PSMB7 CCNE2 PSMB4 CHEK1 PSMB5 CSNK1E CCNE1 NEK11 UBB PSMB2 PSMB3 UBC PSMB1 COP1 RPS27A PCBP4 FBXW11 ADRM1 MAPK14 MAPK11 PSMC5 CHEK2 PSMC6 SEM1 PSMC3 PSMC4 PSMC1 PSMC2 SKP1 CCNA2 TP53 CCNA1 ATM CUL1 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 95%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L RBBP5 DPY30 WDR5 KMT2D BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME DATABASE ID RELEASE 95%77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB ACADL HADHA SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 95%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBC RPS27A VPS28 TSG101 VPS37C UBA52 VPS37D VPS37A VPS37B MVB12B MVB12A UBAP1 NMT2 UBB SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants MAPK1 MAP2K1 MAP2K2 MAPK3 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection BAIAP2 ABI2 ABI1 ARPC1B ARPC1A ABL1 ARPC4 ARPC5 IGHV3-23 ARPC2 ARPC3 IGLV ACTR3 IGLV2-8 ACTR2 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 FGR IGHV3-30 IGHV3-33 IGKV1D-39 IGKV1D-33 IGKV2D-28 IGKV4-1 IGHV7-81 NCKIPSD WIPF1 IGKV2D-30 WIPF2 IGHV4-59 CYFIP2 WIPF3 IGHV1-69 ELMO1 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 IGKV2D-40 IGHV3-11 IGHV3-13 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 CRK IGKV3-20 IGHV4-34 IGHV1-2 IGHV1-46 CD3G IGHV4-39 IGHV IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 IGKV3D-20 IGKV2-30 IGLV3-19 WASL IGHV2-70 IGHV2-5 ACTG1 IGLV3-1 IGHV3-48 IGLV3-25 IGLV3-27 IGKC IGKV1-39 IGLV3-21 IGKV1-33 FCGR3A MYH2 MYO10 IGLC7 IGHV3-53 MYO1C IGKV5-2 NCK1 WAS IGLC6 IGKV1-5 RAC1 WASF3 VAV3 MYO9B MYH9 VAV1 VAV2 IGHG3 IGHG4 IGHG1 IGHG2 V2-11 V3-4 V3-3 V2-17 V3-2 V2-15 V2-19 MAPK1 V1-11 V1-16 V1-13 ELMO2 MAPK3 V2-8 CDC42 V1-20 V1-9 V5-4 V1-7 V5-1 V1-5 V1-3 V5-6 V4-6 V4-2 V4-1 CYFIP1 NCKAP1 DOCK1 BRK1 LYN BTK ACTB MYO5A YES1 HCK SYK FYN NCKAP1L WASF1 PTK2 WASF2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 95%167162 RNA Polymerase II HIV Promoter Escape CCNH POLR2A POLR2B TBP POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H TAF9 POLR2I TAF1L POLR2J POLR2K POLR2L GTF2H1 TAF15 GTF2H2 TAF12 GTF2H3 TAF13 GTF2F1 TAF11 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TAF8 ERCC2 TAF7 MNAT1 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TAF7L TAF10 GTF2A1 GTF2A2 TAF9B GTF2B TAF4B GTF2E1 GTF2E2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 95%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 95%9032500 Activated NTRK2 signals through FYN DOCK3 RAC1 GRIN2B NTRK2 BDNF SRC MRNA SPLICING%REACTOME DATABASE ID RELEASE 95%72172 mRNA Splicing SNRNP200 SRSF6 SNRPC SRSF7 SRSF8 SNRPA SNRPB SRSF9 DDX5 RBM8A PRPF8 ZMAT2 ZMAT5 CCDC12 FUS ALYREF YJU2 CWC15 LSM5 LSM4 LSM3 LSM2 CHERP LSM8 LSM7 LSM6 ISY1 RBM25 DDX46 DDX42 PPWD1 YBX1 USP39 PTBP1 SART1 SNRNP70 RBM7 BCAS2 RBM5 CTNNBL1 RBM17 BUD31 TFIP11 PLRG1 SYF2 C9orf78 LUC7L3 SNRPA1 DNAJC8 NSRP1 RBM22 SRSF1 PRCC DDX23 WBP4 U2AF1 U2AF1L4 RNF113A PUF60 U2AF2 SAP18 SNRPB2 SMNDC1 RBM39 HNRNPA3 PPIL1 PPIL2 GPKOW CDC5L U2SURP SNRNP40 MFAP1 RBM42 ACIN1 SNRNP48 BUD13 PPIL3 PPIL4 FAM50A HNRNPA1 DDX39B POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 GTF2F2 HSPA8 SRRM1 TRA2B HNRNPC RBMX DDX41 STEEP1 TCERG1 EIF4A3 GPATCH1 HNRNPU HNRNPR CCAR1 PNN SNRPD2 SNRPD1 MAGOH SNRPD3 SRRM2 AQR CRNKL1 CDC40 ZNF830 SF1 DHX8 DHX9 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PCBP1 PCBP2 DHX38 RBM10 ZRSR2 PRPF38A UPF3B MAGOHB HNRNPL SMU1 HNRNPM SNW1 HNRNPK HNRNPF HNRNPD RNPS1 SUGP1 NKAP PRPF19 PQBP1 UBL5 DHX15 DHX16 PRPF40A GCFC2 PRPF18 HNRNPH1 SDE2 FAM32A HNRNPH2 CACTIN SLU7 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT PPP1R8 SF3B1 SRSF10 SRSF11 SRSF12 SF3A3 SF3A1 SF3A2 XAB2 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CASC3 CWC27 EFTUD2 RBMX2 CWC22 SNIP1 NCBP1 MTREX NCBP2 TXNL4A SNRNP35 IK SNRPN PRP4K ZCRB1 WBP11 LENG1 PRPF4 PRPF6 PRPF3 SNRPG SRSF2 SNRNP27 PPIE SRSF3 SNRPE SRSF4 PPIH PPIG SNRNP25 SNRPF SRSF5 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.4 Depolymerization of the Nuclear Lamina PRKCB PRKCA EMD LMNB1 LPIN1 CCNB1 LPIN2 LPIN3 CNEP1R1 CDK1 LEMD3 LEMD2 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 95%3304347 Loss of Function of SMAD4 in Cancer SMAD2 SMAD4 SMAD3 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 95%8983711 OAS antiviral response OAS1 OAS3 ABCE1 RIGI RNASEL FLNA OAS2 PDE12 OASL PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 95%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane TMEM258 DAD1 OSTC STT3A STT3B RPN2 TUSC3 PDCD1LG2 B3GNT3 RPN1 PDCD1 MAGT1 MIB2 OST4 JAK1 CD274 DDOST RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.2 RHO GTPases activate KTN1 CDC42 KLC4 RAC1 KLC3 KLC2 KTN1 KIF5B RHOG KIF5A RHOA KLC1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 95%163125 Post-translational modification: synthesis of GPI-anchored proteins LY6E CD109 LYPD1 LYPD2 LYPD3 THY1 LYPD4 LYPD5 LYPD8 BST1 LYPD6B PIGO VNN1 PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH ALPI LY6K GPIHBP1 LY6D LY6H SPRN SPACA4 MDGA2 RECK MDGA1 NRN1 ART3 ART4 NTNG1 NTNG2 CD52 PRND CNTN5 CEACAM5 ALPL CNTN3 CNTN4 ALPG TEX101 GPLD1 GP2 PRSS21 PRSS41 DPM1 DPM2 DPM3 TECTA TECTB VNN2 PIGS PIGU PGAP1 PIGT GPAA1 PLET1 CPM PLAUR PIGK PSCA MELTF RTN4RL2 MSLN FCGR3B RTN4RL1 OTOA RAET1G RAET1L IZUMO1R CEACAM7 NRN1L LY6G6C LY6G6D LSAMP NTM FOLR2 ULBP2 OPCML NEGR1 XPNPEP2 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 95%190873 Gap junction degradation CLTC CLTB GJA1 CLTCL1 CLTA DNM1 DNM2 DAB2 MYO6 AP2M1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis RXRA JUN H2BC9 H2AZ2 H4C9 YY1 H2BC8 H2BC5 H2BC3 H2BC1 HOXA2 H2AC20 HDAC3 PBX1 PAX6 RARG CTCF HOXA3 EGR2 HOXA1 PKNOX1 ASH2L HOXA4 PIAS2 CNOT6 HOXB4 NCOR1 HOXB3 HOXB2 HOXB1 HOXD1 HOXC4 MEIS1 MAFB HOXD4 HOXD3 ZNF335 CNOT9 SUZ12 PAXIP1 RARB DPY30 AJUBA PCGF2 WDR5 POLR2A POLR2B POLR2C EED POLR2D NCOA6 POLR2E NCOA3 POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RBBP4 EZH2 RBBP5 RBBP7 H2AX KMT2D CREBBP H2AB1 H2AC19 H2BC26 H2AC14 KMT2C H2BC12L H2BC21 EP300 H3-3B H3C8 PAGR1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 KDM6A H2AJ H2BC15 H2BC11 RARA H3C15 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 95%202131 Metabolism of nitric oxide: NOS3 activation and regulation CYB5B NOSTRIN HSP90AA1 NMT1 LYPLA1 CYGB NOS3 SPR DDAH1 NOSIP WASL DNM2 NMT2 AKT1 ZDHHC21 CALM1 CAV1 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB PDHX FH SUCLA2 MPC1 SUCLG2 HEL-S-133P SUCLG1 GPT DHTKD1 PCK2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260211%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN3 COMP MATN1 COL9A1 COL9A3 COL9A2 FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260211%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor ACTA2 MAPK10 COL1A1 MAPK9 MAPK8 TGFB1 STAT3 ENPP2 RHO LPA CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260211%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMC4 TUBA2 PSMC1 STUB1 TUBA8 UBE2L6 PARK2 UBE2L3 HEL-S-89n TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD5 PSMD2 RNF19A TUBB1 PSMD3 PSMD1 GPR37 FBXW7 HEL-S-103 TUBB HEL-S-72p CASK SEPT5 TUBA4B TUBA4A TUBB2A CCNE1 PSMD10 PSMD12 PSMD11 HEL-S-91n TUBAL3 PSMD13 HSPA14 UBE2J2 UBE2J1 TUBA3E SNCA HSPA4 SIAH2 SIAH1 UBE2G1 HSPA2 UBE2G2 SNCAIP TUBB4B TUBB4A PSMC6 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260211%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation CRTC2 FLT1 INSR PDX1 PDGFA BRAF IGF1 FOXM1 TGFBR1 FOXO1 IGF1R INS RAB43 RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260211%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways RGS16 CAMK2A ADCY3 ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G CORIN GUCA2B GUCA2A RGS10 ACKR3 RGS11 RAMP1 ACKR5 ACTA2 ATF1 ATF2 MYLK2 HEL2 OXTR CRCP GABPB1 ETS2 SLC8A1 RXFP2 ACTG1 RGS4 RGS5 RGS2 GJA1 RGS1 RGS6 RGS7 IGFBP1 PRKCH IGFBP5 PRKCB IGFBP4 PRKCE IGFBP2 PRKCA DGKZ MYL4 CACNB3 ADCY9 PRKAR1B PRKAR1A MYL2 PRKCQ PRKD1 ATF5 ATF3 ATF4 CALCA LPAR1 HEL-S-14 ITPR2 PRKCZ CRHR1 CNN2 GRK5 GRK4 CALD1 PLCG2 SFN PLCG1 IGFBP6 JUN GNG12 GNG11 NFKB1 GNG13 PKIB IL6 SP1 PKIA GNB2 MAFF GNB1 GNAS GNB4 GNB3 RLN1 GNB5 PKIG CALM1 RYR1 RYR2 ATP2A2 ADM OXT ARRB2 RYR3 GNGT1 YWHAQ PS1TP5BP1 PDE4B HEL-S-1 YWHAG GABPA HEL-S-21 PDE4D FOS YWHAZ CREB3 ACTA1 PLCB3 CREB1 IL1B CRH RGS18 RGS17 CAMK2D RAMP2 RAMP3 RGS14 ATF6B 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome MYC DYNC2I2 HEL-S-71 NRROS TFRC CEP19 HFE SLC40A1 PIGX H2BC21 UBXN7 SMCO1 DYNC2H1 NCBP1 DYNLT1 NCBP2 DYNLT3 ADAM10 SLC51A SLC51B SIRT1 DYNLL2 FNDC8 RNF168 PIGM MFI2 DYNLT2B PXN MYCBP2 RNF8 PIK3R3 FBXO45 HIF1A DYNC2LI1 ZDHHC19 BRINP1 STAT5B TM4SF19 CEP350 MCRS1 RABL2B MAD2L1BP WDR53 ZNF76 TF DYNLRB2 NF2 DNCL1 HAMP TGFB1 JUN FBXW7 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260211%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260211%WP2249%HOMO SAPIENS Metastatic brain tumor CDC42 CDK6 E2F3 MYC PIK3R1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260211%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 PARP1 NAMPT TFAM HIF1A PPARG FOXO3A ROS1 SIRT1 SIRT3 FOXO1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 MAPK1 MAPK3 PIK3R1 SLBP CBL FGF2 ERI1 NSD2 TMEM129 CLTCL1 NELFB UBE2J2 FAM53A NELFCD NELFA POLN H3F3B FRS2 CKAP5 LETM1 NICOL1 TACC3 GRB2 NAT8L SOS1 FGFR3 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260211%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD MEF2C MEF2B CCND2 NKX2-5 KLF4 MEF2D CAMK2D MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260211%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260211%WP5548%HOMO SAPIENS Blood based neuroinflammation markers ADM CRP PBR GRN CCL23 CCL11 BDNF TREM2 DBI S100B TREM1 CX3CL1 IL6 GFAP CCL5 IL1B OLR1 TNF CHI3L1 NEFL CCL2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260211%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA4 APOB LDLR PLTP USF1 GPIHBP1 LPL GHR LIPC EPHX2 APOA2 PCSK9 LUPUS THERAPIES%WIKIPATHWAYS_20260211%WP5560%HOMO SAPIENS Lupus therapies IL6 C1QB C1QA CD40 IL25 CD80 C4B_2 C2 C4A CD19 IL12B TNLG7A IL12A IL6R HEL-S-62p CD40LG IFNG IL23A IL17F IL17D IL17C MS4A1 IL17B CD22 IL17A C1QC EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260211%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC1H1 DYNC2H1 DCTN1 TRAK1 ATAT1 DYNC1LI2 RHOT1 SYPL1 CASP3 MAP2 BAX MFN2 KIF1B RABAC1 DYNC1I1 RAB7A SNCA DYNC2I2 CASP8 RAB3B ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260211%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PIK3R3 APP CALML6 ARAF CALML3 FZD10 CALML4 FRAT1 FRAT2 HEL-S-162eP CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E ATG14 DKK1 DKK2 DKK4 SFRP4 DDIT3 CSNK2B VDAC3 ULK2 ULK1 PIK3R4 PIK3R2 PIK3R1 PPP3R1 APH1B PPP3R2 FADD NRBF2 APOE FZD1 WNT10B WNT10A FZD3 XBP1 FZD2 FZD5 FZD7 FZD9 EIF2AK2 FZD8 GRIN2B ATG2A NOX4 ATG2B IDE IKBKB PPP3CA CASP12 PPP3CC HRAS PSENEN APC2 MME BACE1 IL1A PLCB4 PSMA4 PSMA2 PLCB1 PLCB2 KNS2 PTGS2 RELA PSMA8 PSMB6 NRAS PSMB2 PSMB3 CSNK1A1 WNT7B WNT7A GRIN1 FAS CTNNB1 CDK5R1 HEL-S-276 CSF1 IRS1 IRS4 TNF KIF5A MAP3K5 HEL-S-61 MAP2K1 MAP2K2 WNT5B CYBB ERN1 ADAM17 PPIF RAF1 RTN3 CHRNA7 PSEN2 LPL GPR83 CACNA1C PSEN1 CACNA1F AGER RTN4 KLC4 KLC3 KLC2 ATG101 DVL1 DVL2 DVL3 NAE1 CACNA1S WNT1 WNT3 WNT4 WNT3A SHFM1 EIF2S1 CDK5 CYCS MCU GSK3B WNT2B PIK3CD ATP2A1 CASP9 RB1CC1 CASP3 CHUK APAF1 AXIN1 TRAF2 WIPI1 WIPI2 AXIN2 WNT16 TNFRSF1A PIK3CA SLC25A5 SLC25A4 SLC25A6 BECN2 LRP5 AMBRA1 HSD17B10 LRP6 NOS2 BAD ADRM1 MTOR APC SLC25A31 CSNK1A1L MAPK10 MAPK9 MAPK8 TUBB8 PSMD9 TUBA1C TUBB6 PSMD6 TUBA1B PSMD7 TUBA1A CASP8 PSMD4 PSMD2 TUBB1 PSMD3 PSMD1 TUBB TUBA4A TUBB2A PSMD12 HEL-S-91n TUBAL3 PSMD13 TUBA3E SNCA TUBB4B TUBB4A PSMC6 PSMC4 TUBA2 PSMC1 TUBA8 INSR BRAF INS AKT3 MAPK1 KRAS MAPK3 ATF4 ITPR2 NFKB1 IL6 CALM1 ATP2A2 RYR3 PLCB3 IL1B ALSTROM SYNDROME%WIKIPATHWAYS_20260211%WP5202%HOMO SAPIENS Alstrom syndrome VCP IFT172 BLOC1S4 VCPIP1 IFT74 BLOC1S6 BLOC1S1 CEP192 E2F4 CIMAP3 SNAPIN PTCH1 CEP19 RFX2 DTNBP1 RFX3 RFX1 ACTN4 TUBG1 DNM3 TFDP2 SMO RILPL1 IFT81 MYO5B GPR161 ALMS1 IFT27 STX5A IFT25 RABL2B SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260211%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition SMAD2 SMAD4 HEL113 TNC RUNX2 CDH6 CDH2 ID1 SNAI1 SNAI2 CDH16 AKT3 MAPK1 MAPK3 VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260211%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression ITPR2 TPH2 TPH1 KDM3A GRIN1 CHRM1 KDM1A KDM1B CYP27B1 CALB1 RXRA KDM6B NR1i1 ATP2B4 ATP2B3 ATP2B2 ATP2B1 HEL-75 CYP27A1 GCLC KCNQ2 BCL2 SLC8A1 KCNQ3 PVALB NFE2L2 CACNA1C GRIN2B VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260211%WP3871%HOMO SAPIENS Valproic acid pathway HADHB CYP2C9 CYP2A6 HSD17B10 CYP2B6 HDAC1 EHHADH IVD ABAT ACADSB FERROPTOSIS%WIKIPATHWAYS_20260211%WP4313%HOMO SAPIENS Ferroptosis TFRC SLC40A1 CYBB GCLC STEAP3 CISD1 SAT2 SLC7A11 BACH1 MAP1LC3A MAP1LC3C AIFM2 FTH1 SLC39A8 HEL-S-64p HEL-S-102 SLC38A1 GPX4 ACSL1 SLC11A2 ACSL6 FACL4 ACSL5 ACSL3 TF SLC39A14 POR DKFZp762B153 CHMP6 CHMP5 FTL IREB2 ALOX15 SLC3A2 HMGCR DPP4 FTMT CBS PCBP1 PHKG2 HMOX1 FDFT1 ATG5 PRNP AKR1C1 AKR1C2 CP COQ2 LPCAT3 VDAC3 CTH GCLM NOX4 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260211%WP2267%HOMO SAPIENS Synaptic vesicle pathway STX1A SLC25A4 NAPA SNAP25 SLC22A3 STXBP1 CLTC DNM3 CACNA1B CLTA SLC1A3 CACNA1A AP2A1 CPLX2 CLN8 CPLX1 AP2A2 HEL-S-67p RIMS1 AP2S1 SLC17A6 SLC17A7 SLC17A8 CLTCL1 STX2 SLC18A1 SLC18A2 AP2M1 SLC18A3 UNC13B UNC13C UNC13A SYT1 SLC32A1 SLC38A1 SYP SYN2 SYN1 STX1B STX3A VAMP2 HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260211%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming IFITM3 ANKRD13C CREBBP HDAC2 CADM1 IRS1 TET2 EP300 PIP4K2A HDAC1 NOL9 EZH2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260211%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG GATA3 GATA2 KLF15 KLF2 PPARG DDIT3 CEBPA CEBPB EGR2 KLF5 CEBPD ROTENONE METABOLISM%WIKIPATHWAYS_20260211%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260211%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins DKFZp762B153 RB1CC1 RAB7A ATG5 PRKAA2 CALCOCO2 HEL-S-30 PPP1R9A RPTOR LARP1 MTOR ULK1 DEPTOR LAMP2 MLST8 VPS11 APOB VPS39 EIF4B VPS16 ATG3 VPS18 GABARAPL2 VPS33A RPS6 ATG9A ATG12 VAMP8 TMEM59 RPS6KB1 RHEB ATG16L1 AKT1S1 VPS41 NBR1 LAMTOR1 SQSTM1 ATG2B OPTN INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1984%HOMO SAPIENS Integrated breast cancer pathway EP300 GRN SIRT1 RHEB MYCBP2 RB1 SMEK1 ZMYND8 NAB1 DHTKD1 MAP3K7CL AHR STK11 CCND1 ZMIZ1 CHEK2 ALKBH1 CHEK1 DAG1 RPP38 RALGAPA1 TSC2 CSNK1D TSC1 ARAF PPP4R3B BAX MYT1 RHO CCNB1IP1 CDC25B PIAS1 MSH6 EDAR MSH2 LGALS13 BLM MAX RASGRP3 RAP1A RRAS NUP85 TPR BARD1 CASP8 UBE2F SMAD1 PLK3 APOBEC3G GADD45A PIK3R2 XRCC3 PLK1 ERAL1 SMAD6 SMARCA4 FADD FOSL2 FOSL1 FER CDK7 NOXA1 NF1 MDM2 ATM ZNF655 MAP3K13 CERK BMPR1A ATR PIGR GSK3A BMPR2 GDI1 TRADD PTEN BRCA1 BRCA2 RASGEF1A RAC1 JAK1 ANXA1 DCAKD TGFBR2 ITPKC USP15 RALA USP16 SELENOK TFPI SMAD2 EGFR SMAD4 AURKA PAK1 BAK1 STAT1 USP21 MRE11A BRAF PML HIPK2 VEGFA TGFBR1 MAP3K7IP1 FOXO1 WEE1 RAD50 RAD51 FILIP1 CTNNB1 FAU CDK4 MYC IRS1 CDK2 MAPK1 KRAS ATF1 BCL2 HDAC1 BACH1 CASP9 CASP3 CHUK HMGCR JUN NFKB1 SP1 PKIA BAD MTOR CDC42 CREB1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260211%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP9 CASP3 APAF1 BAX TNFRSF1A NEF3 TOMM40 SLC1A2 DERL1 HEL-S-2 TNF NEFH NEFL MAP2K6 MAP3K5 GPX1 BAD HEL-S-44 MAPK14 MAP2K2 CCS SMIM40 RAB5A BCL2L1 BCL2 PPP3CA CASP12 RAC1 PPP3CC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260211%WP1533%HOMO SAPIENS Vitamin B12 metabolism RELA INSR CRP CBS INS NFKB1 IL6 CCL5 TNF CCL2 CTH HEL-S-44 SCARB1 APOB SERPINA3 LDLR MTRR SAA4 HBB APOE MTR PLAT PLG HEL-S-51e MPO MCEE ABCA1 FGA CUBN CBLIF HBA2 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG TCN2 TCN1 IL1B ALB SAA1 SAA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260211%WP3925%HOMO SAPIENS Amino acid metabolism TPH1 HEL-S-30 HEL-75 EHHADH PDHX FH HEL-S-133P SUCLG1 HEL-S-64p PNMT HEL-S-32 HEL-S-61p DBH FTCD GLS TDO2 HEL-S-53e PDK4 ACADM PIG59 HEL-S-4 ARG2 RARS1 ARG1 GPT2 MCCC1 CAD SDHA HEL-S-26 CBS ACLY LARS2 SMS BCAT1 ALDH7A1 DLD DDC ADH1C PPM1L MAOA HDC ADH7 CTH ADH5 GCLM SRM HMGCL TPO PCK1 ACSS1 PDHA1 MDH2 GOT2 ASNS ASS1 CS GLUD1 G6PC2 HAL PC TH EPRS1 P4HA2 OGDH ACO2 ALDH18A1 IARS OTC FARSB KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 TDO2 IDO1 FOXO1 KLF5 CDKN1A IFNB1 IFNG AADAT HEL-S-90n HAAO TNF IL1R2 EIF2AK1 AHR EIF2AK4 KMO KYNU AFMID IDO2 PROLACTIN SIGNALING%WIKIPATHWAYS_20260211%WP2037%HOMO SAPIENS Prolactin signaling ITGB1 HEL-S-130P PRL HEL-S-69p PAK1 RPS6KA2 SIRPA RELA STAT1 NEK3 CISH GAB2 PRLR VAV1 VAV2 ZAP70 PPIB SRC SHC1 AGAP2 SOCS2 MYC SOCS3 SOCS1 IRS1 ERBB2 EIF4EBP1 MAPK1 FLNA FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 NFKBIB RAF1 RPS6 RPS6KB1 PXN STAT5B GSK3B MAPK9 MAPK8 CASP3 STAT3 JUN PIK3CA NFKB1 MTOR PIK3R2 PIK3R1 CBL YWHAG FOS YWHAZ RAC1 JAK1 HRAS GRB2 SOS1 CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260211%WP4504%HOMO SAPIENS Cysteine and methionine catabolism pcap ETHE1 MAT1A SQOR SUOX CDO1 MTR HEL-S-64p CTH HEL-S-61p CBS GCLC COMPLEMENT SYSTEM%WIKIPATHWAYS_20260211%WP2806%HOMO SAPIENS Complement system CRP CSNK1A1 FCN1 FCN2 CLEC4M CD40 ITGB3 PLG PROS1 ITGA2B ICAM2 F13A1 C2 C4BPA C4A FGA LAMC1 CD19 C8A FCGR3A IBSP RPS19 C1QBP PRKCA HEL-S-62p HEL-S-78p C3AR1 VSIG4 MBL2 CR2 CR1 ALB CD93 ITGA2 HEL-S-92n PLAUR DCN FCER2 SERPING1 MASP2 MASP1 CD46 CFD LAMA5 FKBP2 SELPLG SFTPA2 CFH C5AR2 CFI C5AR1 WAS FPR1 GNAI3 TXN HEL-S-99n CFP THBS1 CPN1 VTN PRNP GNA15 C6 C7 C9 SPP1 CD59 CD55 ELANE F10 F11 LAMB1 SELE SELP SELL CFHR2 ADM CFHR4 PTX3 ARRB2 SFTPA1 KLKB1 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260211%WP4917%HOMO SAPIENS Proximal tubule transport SLC34A3 ATP6V1G1 SLC6A19 ATP6V0B ABCC2 SLC6A18 SLC36A2 ATP6V0E1 SLC34A1 SLC16A10 SLC3A2 ATP1B1 SLC9A3 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C SLC22A7 ABCG2 ATP6V1B1 SLC47A2 ATP6V1A SLC22A6 ABCB1 SLC47A1 SLC22A2 SLC1A1 SLC2A2 SLC3A1 SLC5A1 ATP1A1 SLC5A2 SLC6A20 SLC4A4 AQP1 SLC5A5 CLTRN CA4 ATP6V0A4 ATP6V1E1 ATP6V1D ATP6V1C1 ATP6V1F SLC22A11 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260211%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway ACTA2 COL1A1 RAF1 SMAD4 TGFB1 CTGF TGFBR1 NOX4 HIF1A RRAS SP1 IL11 JUND MAPK1 IL11RA MGRA MAP2K6 ACE2 PTPN11 COL1A2 TGFBR2 PDGFD AGTR1 IL6ST OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260211%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development NOTCH3 NOTCH1 DMP1 HNF1A BMP7 KLF4 DSPP ALPL RUNX2 SP7 SOST CTNNB1 DKK1 NOTCH2 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260211%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies GSK3B SMAD2 CREBBP TGFB1 RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 WNT7B CEBPD CTNNB1 CDK4 MAOA SPP1 APC CSNK1A1L NOTCH1 PPARG WNT10B HDAC1 LEF1 TNFRSF11B PS1TP5BP1 ZMPSTE24 FNTA CTSK LMNA HES1 EMD JUNB HES5 TCF7L2 CDKN1A TCF7L1 ICMT RB1 HMGA2 DICER1 LEMD3 TARBP2 GDF8 KAT2B BMP2 MYOD1 AGO2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG MAFK COX1 NFE2L2 PTGS2 CYP2A6 VEGFA JUN FOS NFKB1 IKBKB NFKBIA KEAP1 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias EBP CYP51A1 SC5D DHCR24 DHCR7 LBR NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members GSK3B CREBBP EP300 CHUK ZC3HAV1 RELB TBK1 IKBKG BTRC SKP1 TIPARP TFPI2 PARP16 PARP14 PARP12 RBX1 PARP10 CLDN6 MAVS MAP3K14 RIGI NFKBIA ERN1 PARP1 NFKB2 IKBKB LUPUS PATHOGENESIS%WIKIPATHWAYS_20260211%WP5559%HOMO SAPIENS Lupus pathogenesis ICOS TLR4 ICOSLG CD40 CD80 TNLG7A IL6 CD40LG IFNA2 TNFRSF13C BCR TLR9 IL17A TLR7 PDCD1 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260211%WP3945%HOMO SAPIENS TYROBP causal network in microglia HCLS1 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ZFP36L2 ADAP2 HLX CYTL1 NCKAP1L SH2B3 TGFBR1 IL10RA SLC7A7 LHFPL2 HIMAP2 GAPT NRROS GPX1 RGS1 HEL-S-62p C1QC SPP1 CD84 ITGAM FKBP15 NCF2 PLEK LOXL3 TCIRG1 PPP1R18 CXCL16 PYCARD LYL1 RPS6KA1 CREB3L2 ITGAX CD37 GAL3ST4 IL13RA1 RNASE6 IL18 HEL-S-66 TNFRSF1B RUNX3 LGALS9C APBB1IP MAF TYROBP BIN2 ELF4 NPC2 DPYD EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260211%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance EGFR PDGFA NRAS BRAF IGF1 VEGFA IGF1R SRC KDR SHC1 PDGFRA PDPK1 MYC HGF AKT3 RRAS2 NRG1 ERBB2 NRG2 EIF4EBP1 MAPK1 SOS2 KRAS MET MAPK3 SHC4 SHC2 MAP2K1 SHC3 PDGFD MAP2K2 TGFA BCL2L11 ERBB3 PDGFC BCL2L1 EIF4E BCL2 EGF RAF1 AXL RPS6KB2 FGFR2 RPS6 RPS6KB1 PRKCB IL6R PRKCA PIK3R3 CCND1 GSK3B PIK3CD STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA IL6 RRAS BAD MTOR PIK3R2 PIK3R1 FOXO3A NF1 FGF2 PTEN JAK1 HRAS GRB2 SOS1 FGFR3 COCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CYP3A4 CES2 CES1 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260211%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGS2 PPARG PTGFR HEL-S-298 EHHADH HPGD PTGDR2 CYP4A22 AKR1B1 PLA2G5 PLA2G6 NR1C2 PTGS1 TBXA2R PTGDR PTGIR PTGIS PLA2G4B CYP4F2 CYP4A11 PTGR1 CYP4F12 ACOX1 PRXL2B ACOX3 PTGES INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260211%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IF2B1 TLR4 IL23R RORC RORA SMAD2 NOD2 IL2RG IL-21 TGFB1 HLA-DMA STAT1 STAT3 IL18RAP TBX21 STAT4 IL21R IL12RB1 IL10 JUN IFNGR1 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL2 IL4 IL6 IL5 TLR5 TNF IL12A IL18 IFNG IL23A IL17F MAF IL1A IL3 SIGNALING%WIKIPATHWAYS_20260211%WP286%HOMO SAPIENS IL3 signaling PIK3CD MAPK8 TGFB1 STAT3 GAB2 VAV1 JUN SRC SHC1 CXCL8 IL5RA MAPK1 CSF2RB CRKL FYN MAPK3 INPP5D BAD ENPP3 PTPN11 CCR3 MAP2K1 LYN PIK3R2 SYK PTPN6 PIK3R1 IL3 IL3RA BCL2L1 BCL2 RAPGEF1 CD69 RAF1 YWHAQ CBL HEL-S-1 FOS JAK1 STAT5B HRAS GRB2 SOS1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260211%WP408%HOMO SAPIENS Oxidative stress response MAPK10 HMOX1 NFKB1 SP1 MAOA GPX1 HEL-S-44 MAPK14 HEL-75 CYBB GCLC MGST1 GSTT2 NFE2L2 TXN2 UGT1A3 XDH NQO1 GPX3 TXNRD2 NOX3 CYP1A1 NOX5 JUNB FOS NOX4 FELBAMATE METABOLISM%WIKIPATHWAYS_20260211%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4 CYP2E1 ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260211%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B1 FABP6 SLC10A2 ABCB11 ABCC2 SLC51A SLC51B ABCB1 ABCC3 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260211%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI LATS1 TEAD4 LATS2 HDAC3 NF1 HDAC1 SIN3A MERTK SKIL TEAD2 TEAD3 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260211%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ECHS1 ACSF3 ACAT1 PCCA PCCB DBT MLYCD BCAT2 MCCC1 IVD ACADSB BCAT1 DLD HSD17B10 ACAD8 MCCC2 FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260211%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 FGFR4 IL10 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260211%WP3927%HOMO SAPIENS BMP signaling in eyelid development NOTCH1 EGFR SMAD4 MAPK9 FGFR2 FOXC2 FOXC1 MAP3K1 INHBB BMP4 JUN SHH SFRP1 DKFZp781O1323 PITX2 FGF10 DKK2 MAPK3 SMAD1 TGFA HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260211%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling IFITM3 MAPK10 MAPK9 MAPK8 RPS6KA2 MAP3K1 JUN IFITM1 IFITM2 RPS6KA3 MAP2K3 MAPK1 MAP2K4 MAPK12 DDIT3 MAP2K6 MAPK3 MAPK13 BST2 ATF2 MAPK11 MAP2K1 MAPK14 IFI27 MAP2K2 MAP3K10 MAP3K11 EIF4E BCL2 RAF1 RPS6KA1 JUNB FOS FOXA2 PATHWAY%WIKIPATHWAYS_20260211%WP5066%HOMO SAPIENS FOXA2 pathway GSTM2 MTTP APOB ACACA MLXIPL ABCC2 FASN PPARGC1B SLC27A5 FOXA2 FOXO1 ABCC3 INS SLCO1B1 IRS1 FOXA1 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260211%WP229%HOMO SAPIENS Irinotecan pathway SLCO1B1 ABCC2 ABCG2 BCHE CYP3A4 CES2 UGT1A10 CES1 ABCC1 UGT1A1 UGT1A9 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260211%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 WNT3 LRP6 FZD3 WNT3A NEUROD1 CCND1 PROX1 NEUROG2 WNT7A NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260211%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 TICAM1 PARP1 TRADD FADD MAPK8 FTL CASP8 TNF RIPK3 TNFRSF1A CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260211%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia SMAD2 SMAD4 RELA EP300 CHUK STAT3 RELB IGF1 CEBPB IKBKG IGF1R TNFRSF1A NFKB1 IL6 TNF RPTOR MAPK11 MTOR NFKBIA MLST8 FOXO3A AKT1S1 TWEAK IL6R MAP1LC3A TRIM63 TNFRSF12A NFKB2 IL1R1 IKBKB FBXO32 ACVR2A IL1B REL JAK1 GDF8 IL1A LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260211%WP4299%HOMO SAPIENS Lamin A processing pathway ICMT ZMPSTE24 LMNA BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260211%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment BDNF SHC1 PDPK1 EIF4EBP1 PTPN11 NFKBIA BCL2L11 EIF4E RPS6KB2 RPS6KB1 MAPK8 STAT3 BAX CASP8 RAPGEF1 FADD TRADD IKBKB RAC1 SMPD1 HRAS PAK1 NRAS MAP3K1 CTNNB1 MYC IRS1 MAP2K4 MAPK1 KRAS MAPK3 MAP3K5 MAPK11 MAP2K1 HEL2 MAP2K2 BCL2 RAF1 BMP7 LEF1 PRKCH PRKCB PRKCE PRKCA TCF7L2 TCF7L1 ARHGAP35 CFL2 PRKCI TIAM1 PARD3 MAPKAPK2 CYCS RTN4R IQGAP3 GSK3B HEL-S-15 NPTX2 PIK3CD MAP2K5 PRKCZ NGFR CASP9 EEF2 TP73 DOCK7 CHUK WASL APAF1 EEF2K TRAF6 CRK PLCG1 IKBKG ROCK1 ROCK2 JUN HEL-S-47e PARD6B PIK3CA PARD6A MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 LIMK1 ARHA BAD MTOR CDC42 FOXO3A YWHAQ HEL-S-1 YWHAG YWHAZ CREB1 FRS2 GRB2 SOS1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FGFR2 PIK3R3 MAPK10 MAPK9 MAPK8 FZD10 PTCH1 SMAD1 PIK3R4 PIK3R2 PIK3R1 SMO FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 SMAD4 RUNX2 STAT1 FGFR4 BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 WNT5B NOTCH2 NOTCH3 NOTCH1 PRKCH PRKCB PRKCE PRKCA WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PRKD1 BMP2 MYOD1 WNT2B PIK3CD PRKCZ WNT16 PIK3CA MAPK7 LRP5 LRP6 IHH RBPJ FGF7 FGF8 FGF9 SOX9 HES6 PRKDC PIK3R5 JAG2 FZD4 SMAD9 FGF18 FGFR1 PPARG PIK3C2G PIK3C2A GLI3 PIK3C2B HEY2 FGF2 WNT9B FGF7B WNT9A FGF7A WNT8A WNT8B DLL3 DLL4 HES3 MAPK6 HES2 MAPK4 FGF5C FGFR3 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260211%WP5088%HOMO SAPIENS Prostaglandin signaling NLRP3 MMP9 IRF7 KLRD1 TGFB1 CCR2 VEGFA NFKB1 IL6 CSF1 CXCL8 TNF CCL2 PYCARD IL12A IFNG IL1B IL17F PTGER4 CXCL9 IFNA1 AHR PTGER2 CXCL1 IL17A AREG CCL3 IL1A PTGES DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260211%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260211%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF CNP ASCL1 CXCL2 MBP MYT1 SOX8 SOX6 IGF1 SOX5 NKX2-2 BMP4 SHH NKX2-6 MOG LIF OMG OLIG1 OLIG2 SOX10 TNF SOX9 FGF2 IL1B BMP2 CXCL1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A FAN1 CREBBP CHRNA7 ARHGAP11B GOLGA8R CCL5 MTMR10 KLF13 OTUD7A FYN GPR75 GOLGA8O KAT2B GOLGA8Q TRPM1 FANCD2 GRM6 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment NFKB1 MUC1 IL6 IKBKB CHUK RELA TNF NFKBIA IKBKG MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CCNG1 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260211%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGER1 ADCY3 PTGER3 ALOX12 LTC4S PTGS2 GNAI1 ALOX5 ALOX15B ALOX15 ALOX5AP NRAS KRAS GNAS MAPK11 SIRT1 IGFBP5 PTGS1 CDKN1A RB1 PTGIS PTGER4 HRAS PTGER2 PRXL2B PTGES CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260211%WP3594%HOMO SAPIENS Circadian rhythm genes ADCY1 HDAC2 EP300 EZH2 PRKAA2 SIRT1 AHR RORC MAPK10 RORA MAPK9 MAPK8 CSNK1D C1orf51 CRTC1 NPY2R PRF1 UBE3A RORB CCAR2 PPP1CC HTR7 CSNK1E PROK2 HEL-S-80p AgRP PROK1 CHRNB2 UTS2R CPT1A FBXW11 KCNH7 USP2 METTL3 DYRK1A SOX14 CARTPT MTNR1A CLDN4 MTNR1B PSPC1 TIMELESS UTS2 SIK1 DDX5 MAGEL2 KMT2A MAGED1 BHLHB2 CREM TNFRSF11A NPAS2 RAI1 AANAT UBC NKX2-1 DRD1 PTEN DRD2 DRD3 PPARGC1A DRD4 HDAC3 EGR1 SIN3A ZFHX3 OPN4 OPN3 HOMER1 NONO GFPT1 NR1D2 NR1D1 BTBD9 NR2F6 SETX STAR ID2 ID4 HNRNPD ID3 FBXL3 PML SLC9A3 TCF2 OGT ADA TPH2 TOP2A TPH1 KDM5A SUV39H2 CHRM1 SUV39H1 FAS BHLHE41 CDK4 NR1C1 HEBP1 RBM4 DBP JUND SIX3 HEL-S-2 KLF10 KCND2 SFTPC PAX4 MC3R SFPQ NCOR1 ADORA2A THRAP3 MTTP CRY2 KCNMA1 CRY1 AVP NLGN1 PRKAA1 PHLPP1 CIPC HDAC1 CRX RBM4B TYMS NPS PROX1 ATOH7 PROKR1 NFIL3 GNA11 NOCT RPS27A NTRK1 ARNT2 F7 NTRK3 CAVIN3 NR1H3 PASD1 HCRTR2 HS3ST2 HCRTR1 PER2 ATF5 PER1 PER3 ATF4 MYBBP1A GSK3B GHRH LEP KLF9 GHRL NGFR BMAL2 RELB BTRC ROCK2 SKP1 JUN IL6 DDC NOS2 PRKDC NAMPT PPARG TH CREB1 CRH GPCRS OTHER%WIKIPATHWAYS_20260211%WP117%HOMO SAPIENS GPCRs other GPR17 P2RY11 HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 CCR2 OR2A5 LGR6 OR2A4 ADGRL2 GPR18 ADGRL3 OR7E24 ADORA2A GPR83 PTGFR CHRM2 CHRM3 OR1G1 OR2M4 GPR61 C5AR2 ADRA1D HTR2A GPR62 CELSR1 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 HTR7 EDNRA GPR176 GPR132 GNRHR CCR5 GPR135 UTS2R ADGRV1 ALG6 OR1F1 F2R OR2H1 TAAR5 OR1J2 TAAR2 SSTR2 OR1N1 SMO GPR162 CCKBR OR5AC2 FSHR ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 OR1E1 GPR88 GPR84 ADRB2 IL8RB MCHR2 GHRHR DRD3 FY CXCR1 DRD4 CNR1 CXCR3 S1PR1 OR2B6 NTSR1 OR5D3 P2RY13 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5049%HOMO SAPIENS Glycolysis in senescence ENO1 HEL-S-68p RB1 PRKAA1 HEL-S-133P HEL-S-30 HEL-S-162eP RETINOL METABOLISM%WIKIPATHWAYS_20260211%WP5188%HOMO SAPIENS Retinol metabolism HEL-S-53e CYP2A6 CYP1A1 ADH1A RPE65 DHRS4 CYP3A7 SDR16C5 CYP2W1 RDH12 DHRS9 AWAT2 PNPLA4 AOX1 LRAT BCO1 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260211%WP1403%HOMO SAPIENS AMP activated protein kinase signaling PLCB1 CRTC2 INSR PRKAA2 EIF4EBP1 RPTOR PRKAG1 PRKAG2 SLC2A4 ADRA1B ACACA ELAVL1 ADRA1A FASN RPS6KB2 PRKAG3 PPARGC1B NR2A1 PRKAA1 GYS2 GYS1 LIPE PRKACG LEPR PRKAB2 STRADA RPS6KB1 STRADB CPT1C PRKAB1 CCNA2 CAB39 PIK3R3 ADIPOR1 ACACB ADIPOR2 CAMKK1 CCNB1 CAMKK2 INS-IGF2 SLC2A4RG STK11 LEP PIK3CD TSC2 EEF2 TSC1 EEF2K HMGCR PIK3CA CPT1A MTOR PIK3R2 PIK3R1 CDKN1A IL2 SIGNALING%WIKIPATHWAYS_20260211%WP49%HOMO SAPIENS IL2 signaling IL2RG STAT1 STAT3 CISH GAB2 SHC1 IL2 SOCS3 MAPK1 CRKL FYN MAPK3 PTPN11 MAP2K1 MAP2K2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 CBL RPS6KB1 JAK1 STAT5B PTK2B HRAS JAK3 NMI GRB2 LCK IL2RA SOS1 IL2RB CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGA4 IL15 F2RL1 IL2 ITGB7 EGFR DHODH IFNG IL-21 TNF NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260211%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF2S1 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP5094%HOMO SAPIENS Orexin receptor pathway STAR RUNX2 CXCL2 FOXO1 DKFZp781O1323 PDPK1 SLC1A2 EIF4EBP1 MAPK1 TNF MAPK3 PTPN11 MAP2K1 MAPK14 MAP2K2 SLC2A4 EIF4B DYNLT1 BMP7 NFE2L2 DYNLT3 PRKAA1 RPS6 RPS6KB1 PRKCB GNA11 PRKCE PRKCA HIF1A CAMKK2 HCRTR2 HCRTR1 PRKD1 LEP GHRL CASP9 PRKCZ MAPK9 MAPK8 CASP3 GNAI1 STAT3 IL10 MAPK7 IL4 NPFFR1 IL6 DAGLA CXCL8 FSHB SGK1 LHB BGLAP NPY SMAD1 GNAS NPVF VHL MTOR CGA PIK3R2 HCRT PIK3R1 OPRK1 GCG CCK POMC GH1 IL9 GNRH1 ARRB2 TH RPS6KA1 BMPR1A NOX4 CREB1 IL1B MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260211%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHB SDHA CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260211%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP16 MMP9 PRKD3 MMP15 MMP23B PRKCZ SCN8A MMP17 MMP19 BDNF NOS2 SNAP25 AGER SLC2A3 PRKCH MMP21 MMP20 PRKCB MMP25 MMP24 PRKCE MMP27 SCN9A HEL-S-62p PRKCA MMP28 MMP7 TRPA1 MMP2 MMP3 SORD TRPV1 PRKCI MMP10 PRKCQ MMP12 MMP11 SCN10A MMP14 CYTOSINE METHYLATION%WIKIPATHWAYS_20260211%WP3585%HOMO SAPIENS Cytosine methylation TET2 MBD3 TDG TET1 HEL-S-26 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260211%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260211%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MTR TXN AMD1 APIP MAT1A SMS MRI1 IL4I1 MSRA MTAP ADI1 CHDH MSRB2 MSRB3 ENOPH1 SRM HEL-S-61p HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260211%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA TFAP2A ARHGAP29 ARHGEF2 IRF6 TP63 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260211%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 KDR PDGFRA PDPK1 HGF PRKAA2 MET RPTOR MLST8 PDGFC SLC2A4 EIF4E EIF4B EGF ELAVL1 RPS6KB2 FGFR2 GYS2 GYS1 RPS6 LIPE STRADA RPS6KB1 RHEB AKT1S1 CAB39 HIF1A JAK3 STK11 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 ULK1 PIK3R4 PIK3R2 PIK3R1 IL3RA MDM2 SLC2A3 PTEN IKBKB JAK1 HRAS EGFR FGFR4 NRAS VEGFA FGF10 CSF1 IRS1 IRS4 MAP2K1 MAP2K2 FOXA1 HEL-S-125m TCL1B TCL1A ACACA PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 PELO CDC37 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 HIF3A GNGT2 FGF8A RAB8A OSMR COL2A1 KIT PHLPP2 COL11A2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD RAB11B NGFR COL3A1 CASP9 KITLG GHB3 CSF3 CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 PFKFB2 PFKFB1 CSF1R PFKFB4 EFNA5 EFNA4 CHAD FGF20 NOS2 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 FGF16 EFNA3 FGF14 EFNA2 PIK3R5 COL5A3 COL5A2 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 ITGB4 PIK3C2A FLT4 LAMC2 PIK3C2B ITGAE FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C ANGPT4 ANGPT2 ITGB1 LAMB3 ANGPT1 PRL LAMB2 PPP2R3A EPOR RAB10 PIK3IP1 PPP2R2C RAB14 PRLR PPP2R2B PPP2R2D EIF4EBP1 GHR CDKN1B ITGB3 ITGA2B LAMC1 IBSP IL6R ITGA2 COMP COL1A1 LAMA5 THBS1 VTN SPP1 LAMB1 SLC2A2 PPARGC1A CRTC2 TNC FLT1 INSR PDGFA IGF1 FOXO1 IGF1R INS CHRM1 AKT3 MAPK1 KRAS MAPK3 ATF2 COL1A2 PDGFD PRKAA1 PHLPP1 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 F2R GNB3 ITGAM GNGT1 CREB3L2 ITGAX CREB3 CREB1 ATF6B INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260211%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 AKT3 SNCA APP STAT1 CEBPB SRPK2 BACE1 SET BDNF TARDBP MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260211%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer RAF1 BRAF JUN ALK KSR1 SHC1 FOS GAREM2 MYC KRAS SOS2 MAPK3 MAP2K1 MAP2K2 SOS1 INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260211%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR CREBBP HDAC2 RELA EP300 NFATC1 NFKB1 HDAC5 SUPT4H1 HDAC8 SP1 HDAC9 HDAC7 HEXIM1 NFATC3 NFATC2 SUPT5H NFATC4 NFKBIA CDK9 PPP3R1 PPP3R2 HDAC1 NELFB NELFCD NELFA PPP3CA HDAC3 PPP3CC TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260211%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NADSYN1 TDO2 NMNAT1 IDO1 NMRK2 NMRK1 NAPRT NAMPT AADAT HEL-S-90n HAAO KMO KYNU NMNAT3 AFMID NMNAT2 INSULIN SIGNALING%WIKIPATHWAYS_20260211%WP481%HOMO SAPIENS Insulin signaling RPS6KA2 SHC1 PDPK1 SOCS3 SOCS1 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 PTPN11 SHC3 SLC2A4 EIF4E RPS6KB2 INPPL1 CBLC RPS6KA4 GYS2 RPS6KA6 GYS1 LIPE RPS6KA5 GRB14 GRB10 ENPP1 MAP3K8 RPS6KB1 MAP3K6 RHEB GYG1 MAP3K7 INPP4A TRIB3 STXBP3 PIK3R3 STXBP4 RRAD PPP1R3A KIF3A STX4A RAB4A EHD1 EHD2 MAP3K12 ARF1 HEL-S-31 SNAP23 PTPRF FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 TBC1D4 SGK2 ARF6 SNX26 MAP4K3 MAP3K2 HEL-S-42 PFKL MYO1C PFKM SGK1 PIK3R4 PIK3R2 PIK3R1 RAPGEF1 XBP1 MAP3K13 GSK3A PTEN IKBKB RAC1 EGR1 HRAS INSR MAP3K1 FOXO1 IGF1R RPS6KA3 IRS1 MAP2K3 IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 HEL-S-61 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 PRKAA1 PRKCH PRKCB PRKCA PRKCI PRKCQ GSK3B PIK3CD MAP2K5 PRKCZ CRK JUN PIK3CA MAPK7 SH2B2 MAP3K14 MTOR SNAP25 STXBP1 FOXO3A PIK3C2G PIK3C2A CBL RPS6KA1 FOS MAPK6 MAPK4 GRB2 SOS1 VAMP2 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260211%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 TSC2 TSC1 EEF2K NRAS BRAF GAB2 PLCG1 BDNF GRIN1 SHC1 TRPC6 TRPC3 ARC NTRK2 DLG4 EIF4EBP1 MAPK1 KRAS MAP2K1 MTOR RPS6KA1 RPS6KB1 RHEB CREB1 HRAS GRB2 HOMER1 SOS1 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades TFPI APOA2 C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 NR1C1 SP1 GPAM STAT3 CYP1A2 CYP1B1 NR0B2 ACOX1 CYP1A1 JUN PCK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260211%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV STX1A CAMK2A CAMK2G GRIN1 ARC MAPK1 MAPK3 RYR2 NLGN1 NLGN3 CYFIP1 NLGN2 YWHAG NRXN1 FMR1 NRXN3 NRXN2 GRIN2B RPH3A SYNGAP1 DLGAP1 TJP1 DLG2 SHANK1 CAMK2D HOMER1 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260211%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TBK1 NFKB1 IL18 IL6 MAVS IL1B CSF2 TNF CGAS RIGI CXCL9 MITA CCL2 IFIH1 CXCL11 IRF3 TLR8 TLR7 TLR3 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260211%WP1604%HOMO SAPIENS Codeine and morphine metabolism CYP2C8 UGT2B4 UGT1A8 UGT2B7 ABCC2 UGT1A3 UGT1A10 UGT1A1 ABCB1 UGT1A9 ABCC3 SLCO1B1 CYP3A4 IL17 SIGNALING%WIKIPATHWAYS_20260211%WP2112%HOMO SAPIENS IL17 signaling GSK3B TRAF3IP2 IL17RC IL17RB RELA STAT3 IL17RA TRAF3 TRAF6 CEBPB IKBKG CEBPD PIK3CA NFKB1 SP1 MAPK1 MAP3K14 MAPK3 NFKBIB IL25 MAP3K7 IKBKB IL17F IL17D JAK1 IL17C IL17B IL17A ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP697%HOMO SAPIENS Estrogen metabolism UGT2B7 UGT1A3 NQO1 CYP1A2 GSTM1 CYP1B1 UGT1A1 SULT1A1 STS UGT1A9 SULT1E1 CYP1A1 ARSL CYP3A4 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260211%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTX1 SPRYD4 CDKN2A AP3D1 TRMT1 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 TRIP13 LAMTOR3 LAMTOR5 LY6K PLXND1 TUSC2 GEMIN2 LTN1 CPOX ARID4B CALCOCO2 MSI2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 VPS39 KPNA3 EIF4E FADS1 AXL MYLIP ATG3 TNLG5A TPM3 TPM1 STX7 GYS1 UBE4A ATG9A CDKAL1 RAB30 GPD2 TMEM59 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 RAB5C CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP NPRC GAS2L1 SAC3D1 MCL1 CCND1 MPDU1 CD164 VCAM1 BRPF3 HMGA1 SLC4A10 TNFRSF10A NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 BCL6 TRPV6 UBE2S CHMP2A SRPRB MENT DKFZp761E1322 PICALM SLC25A1 DOCK5 ADPGK TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 PTBP1 SMAD1 DNMT3B TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 PPP3R1 UTP15 HSDL1 RBM19 SIGMAR1 ARID1A TXN2 NT5C3A RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 UNC93B1 NXN UHRF1 PLAG1 HSD17B12 MRM1 AURKB GNA13 DNAJB1 CAND1 PPP3CA POLR2C RAB23 TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT ABCF2 SLC25A22 PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 IRS1 MAPK12 MAPK14 TCL1A PPIF MTRR LPL RTN4 KIT PRKCI IQGAP3 DOCK7 RARS1 COL4A2 HEL-S-26 HEL-S-47e MAPK7 CDK6 E2F3 LAMC2 FGF2 P4HA2 NELFCD CDKN1A PPP2R5C PPIB BDNF CDKN1B MAP3K8 LAMC1 SMC1A C1QBP SUCLG2 TNFRSF10B ITGA2 SNAP23 PTPRF CAP1 ATAT1 SYPL1 TUBA1A FBXW11 GPAM DDX5 CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 ATP6V1F GFPT1 ATP6V0E1 CPNE8 VEZT SERPINE2 TMEM41B EHMT1 CLDN1 PWP1 ABCG2 DCAF7 RRP8 PNP DHX57 KRAS LOC541469 CHORDC1 RAVER2 MYB CIAO2A SEC62 GOLGA7 NOTCH2 CDK5RAP3 HOXA5 NOTCH1 BCL2 ARL10 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 OTULINL POM121 HACD3 MRPL20 BACH1 FXR2 COMMD9 TERT RDH10 GRPEL2 CEP72 KCNN4 VTI1B SNX6 SLC38A1 GSTM4 PHC2 HARS1 RAB27B BRI3BP PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B FERMT2 HOXD8 RNP24 RCOR1 CDKN1C NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MEOX2 MRC2 PANX1 COIL CHAF1A SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC ANXA2 MRPS24 ELOVL5 ATP2A2 ELMOD2 AP2A1 TMT1A AP3B1 PRPF40A RHOB SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN PTRH1 VAMP3 PRIM1 MRPS33 SSNA1 AMIGO2 AKAP8 NAPG HEL-S-66 PTPA PURA NT5E PGRMC1 PPP1R7 USP1 SHOC2 TAF9B SRSF10 MPZL1 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP5485%HOMO SAPIENS Post COVID neuroinflammation TLR4 IL10 CCL11 TMPRSS2 IL12A FURIN IL2 HMGB1 IL4 IL18 IL6 GFAP IFNG CXCL8 IL1B MAPK1 TNF IFNA2 ACE2 TLR8 TLR7 IL1A TLR3 IL7 SIGNALING%WIKIPATHWAYS_20260211%WP205%HOMO SAPIENS IL7 signaling GSK3B IL7R IL2RG STAT1 STAT3 IL7 MAPK1 STAT5B FYN MAPK3 JAK1 BAD PTK2B JAK3 MAP2K1 MAP2K2 PIK3R2 PIK3R1 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260211%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 CPN1 BDKRB2 KLKB1 BDKRB1 SERPING1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260211%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260211%WP5574%HOMO SAPIENS Oligodendrocyte development ID2 ASCL1 ID4 MBP MYT1 SOX8 SOX6 NFIA SOX5 NKX2-2 EGR2 BMP4 SHH NKX2-6 PDGFRA OLIG1 OLIG2 SOX10 MYRF CHD8 PTN ZNF24 SMAD1 NFATC2 DUSP15 SOX2 NKX6-1 SOX9 ZNF488 LGI1 OPALIN SOX11 ZBTB33 ZEB2 BMP1 TMEM98 CNTN1 CSPG4 WNT10A FGF2 HES5 TCF7L2 PRKCA RELN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260211%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging PTEN SIRT1 MTOR FOXO1 IGF1R NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260211%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC18A2 DDC MAOA SLC6A3 PNMT TH TPH2 DBH TPH1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260211%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALDH7A1 ALPL HEL-S-302 PLPBP ALPI HEL-S-1a PIGV DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260211%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CSNK1A1 FOXO1 CDK4 DCAF7 RPTOR DEPTOR MLST8 CRY2 NOTCH1 CDKN1B SIRT1 PSEN1 LIN54 NEUROG2 GMNN HES1 DNER AKT1S1 LIN52 RBL2 HES5 RBL1 TFDP1 TFDP3 AMPH LIN37 LIN9 RBBP4 E2F5 EIF2B5 REST CCND1 TFAP4 SPRY2 GSK3B CASP9 TSC2 APP CASP3 TSC1 NFATC1 E2F4 MTOR DYRK1A TFDP2 CDK6 FGF2 CREB1 H3F3B LATS2 PSENEN BACE1 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260211%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IRAK1 IRAK2 IRAK4 MAPK10 IRF7 SAFB MAPK9 TAB3 MAPK8 MYD88 RELA CHUK MBP TRAF6 MAP3K1 MAP3K7IP1 NFKB1 MYC MAP2K3 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB EIF4E RPS6KA5 MAP3K8 MAP3K7 FOS IL1R1 IKBKB MAPKAPK2 TANK IL1A GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260211%WP2363%HOMO SAPIENS Gastric cancer network 2 EGFR OTUD5 DGIC AHCTF1 LBR DSCC1 CHTF18 MTDH CHTF8 BRIX1 TOP2A RFC3 RFC4 UBE2C ATAD2 CACYBP CTNNB1 FAM91A1 MYC RNF144B LMNB2 UBE2T SNURF S100A6 CD48 CEBPZ COL9A1 COL9A3 RAD17 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260211%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 ITGB1 SMAD2 HEL113 FLT1 RELA CXCL2 CDH2 VEGFA SNAI2 IGF1R DKFZp781O1323 SRC KDR SHC1 PDGFRA CTNNB1 CLDN1 PDPK1 SOCS3 RPS6KA3 SOCS1 PRKAA2 MAPK1 TNF MAPK3 CCL2 MAP2K1 MAPK14 MAP2K2 ACACA ZEB2 RAF1 RPS6KA4 SP7 RPS6 RPS6KA5 RPS6KB1 PRKCB IBSP HEL-S-133P HEL-S-102 GSK3B ACTA2 MAPK9 MAPK8 TGFB1 CSF3 PLCG1 IL10 COL4A1 JUN NFKB1 IL6 CXCL8 CRKL CPT1A BGLAP SIX1 SMAD1 CXCL5 HK2 MTOR DUSP4 CLDN5 SLPI PIK3R1 PCNA MST1R SMAD6 KLK15 PARP1 SMAD9 FZD1 FGFR1 WNT10B NR0B2 RPS6KA1 FOS PTEN IFNB1 TJP1 IL1B PPARGC1A CSF2 EGR1 GRB2 CXCL1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders HIST1H2BE TERF2IP TPP1 H2BC21 H2AC19 H2AX H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 ACD H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 TINF2 H2BC1 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H2AJ H2BC14 H3-4 H2BC15 H2AC20 H2BC11 POT1 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260211%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP FPGS UPP2 TDG TK1 RRM1 RRM2 ABCC5 GGH SMUG1 DHFR UCK2 UCK1 ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 XRCC3 CYP2A6 CES2 CES1 TYMS ABCC3 DPYD SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260211%WP4814%HOMO SAPIENS Somatic sex determination SOX8 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 WT1 WNT4 SRY RSPO1 AMH FGF9 SOX9 PDGF PATHWAY%WIKIPATHWAYS_20260211%WP2526%HOMO SAPIENS PDGF pathway MAPK8 PAK1 CHUK STAT1 STAT3 WASL PDGFA MAP3K1 PLCG1 VAV1 VAV2 JUN SRC SHC1 NFKB1 MAPK1 MAP2K4 ARHA MAPK3 PTPN11 MAP2K1 NFKBIA COX2 PIK3R1 CDC42 RAF1 FOS RAC1 JAK1 HRAS TIAM1 GRB2 SOS1 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260211%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease NOTCH3 HEL25 MEF2C HP1BP3 HSPB3 HSPB2-C11orf52 tmp_locus_29 LBR H2AZ1 LMNA ACTA1 MYOD1 MYOG DMPK AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260211%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension UROC1 GLUD1 HAL GPT2 FTCD MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids PIK3CA CERS1 NFKB1 HIF1A ASAH2 TSC1 S1PR3 S1PR1 MTOR CERK SPHK2 IGF1R TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 MEF2C MEF2B CDKN2A CCND2 STAT3 BCL6 ID3 EZH2 IL21R NFKB1 MYC IL6 TLR5 TNFRSF13C BCR LYN TLR9 SYK TLR7 BCL2L1 ICOSLG CDKN1B CD40 SPI1 CD79B SPIB CCND3 CD79A POU2F2 TLR1 IRF4 POU2AF1 IRF8 TCF4 TLR10 TCF3 CDKN1A TLR8 TLR3 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD MAPK8 PAK1 STAT3 STRN ARAF NRAS BRAF CRK PLCG1 JUN ALK SRC PIK3CA RAP1A HGF AKT3 MAPK1 KRAS SOS2 CRKL MAPK3 MET BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 PIK3R1 CDC42 RAPGEF1 RAF1 CBL PIK3R3 CDKN1A PRCC RPL11 ELOA PAK6 RAC1 INSL3 PAK4 HRAS C8orf34 JAK3 GRB2 SOS1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 AIFM1 MIF ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260211%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R11 PPP1R10 PPP1R2 PPP1R8 PPP1R16B MAPK8 MBTPS1 PPP1R14A PPP1R14B PPP1R14C PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3C PPP1R3B HEL-S-89n PPP1R3E PPP1R1C PPP1CC PPP1R1B PPP1R3D PPP1R12B HEL-S-80p PPP1R14D PPP1R12C MBTPS2 DDIT3 PPP1R9A ERN1 BCL2 XBP1 EIF2AK2 MAP1LC3A PPP1R3A PPP1R7 EIF2AK1 EIF2S1 PPP1R15A PPP1R15B PPP1R13B ATF4 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260211%WP3601%HOMO SAPIENS Lipid particles composition APOB LDLR APOE APOC2 LPL APOC3 APOA2 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2874%HOMO SAPIENS Liver X receptor pathway FASN RXRA CYP3A4 NR1H3 CYP2B6 ABCG8 ABCG5 SCD CYP7A1 IL9 SIGNALING%WIKIPATHWAYS_20260211%WP22%HOMO SAPIENS IL9 signaling IL9 IL2RG STAT1 STAT3 MAPK1 STAT5B MAPK3 JAK1 JAK3 MAP2K1 GRB2 MAP2K2 CDK9 IL9R PIK3R2 PIK3R1 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2877%HOMO SAPIENS Vitamin D receptor pathway CDKN2A KLF4 CEBPA TREM1 CYP3A4 NFATC2 SLC2A4 ADRA1B CDKN1B TPM1 CD40 CDKAL1 IL25 IRF4 IRF8 IL12A NR1C2 HIF1A CCND1 TRAK1 TGFB1 ALOX5 BCL6 TRPV6 THBD BDKRB1 BGLAP SPP1 CYP7A1 GADD45A STEAP4 LPGAT1 CCNC GXYLT2 PRDM1 KNG1 CLDN2 SALL4 TNFSF11 LGALS9 EPHB4 SULT2A1 KRT71 SLC34A2 CCNE1 S100A2 ABCB1 MED9 CYP1A1 LCE1F LCE1D LCE2B CDC34 NINJ1 S100A4 S100A9 S100A8 TNLG2B COL13A1 CLEC16A KLK6 CRACR2A CRACR2B DND1 BTLA KRTAP4-1 CD14 FGF23 HLA-DQA2 HLA-DQA1 KL SLC37A2 KRTAP12-2 KRTAP8-1 BMP6 CYP2S1 ID4 TRPV5 PNOC ID1 CLPTM1L STS MXD1 ALPG ZNF257 FOXO1 SPRR1B SFRP1 CD200 HLA-DRB1 ORM1 HILPDA TNFAIP3 MYC CYP27B1 ORM2 ADAMTS5 CDK2 SULT1C2 RXRA CASP14 DUSP10 NR1i1 ADGRE5 CASP5 DACT2 TIMP3 ATP2B1 CTLA4 SOSTDC1 KRTAP5-1 CA9 ABCD1 SLC8A1 CAMP HNF1A KRTAP5-4 KRT34 CEACAM1 CYP2C9 KRT38 DEFB4B CYP2B6 COLEC11 SATB1 TNFRSF11B PTH ALPI HEL57 IGFBP1 SEMA3B ASAP2 IGFBP5 CST6 PTHLH DNER IL1RL1 JUNB CST1 CLMN CREG2 HSD17B2 CDKN2D LRRC25 S100G KRTAP10-2 CDKN2B KRTAP10-4 PRKCQ CDKN2C CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 G0S2 MYO9B DEFB132 CYP24A1 KRT16 CD9 CBS LRP5 EFNA5 S100A6 ITGAM ADRB2 CDKN1A PTGER4 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260211%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins PLCB4 TERF2IP PRKCZ MAPK9 CADM1 CSN3 GRIK2 GPHN CDH2 RAP1GAP CHL1 EPB41L3 NCDN CAMK2G MAP4 NEO1 CLASP1 GRIN1 NTNG1 GABBR2 KCNJ6 CADM3 CAV2 EFNA5 GABRG2 SNW1 DAB1 AGRN ATP2B1 KCNQ2 KCNMA1 CASK STX2 GRIN2B MAPK4 CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260211%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT PPARGC1A SIRT1 IGF1 PRKAB2 MTOR EGF EGFR SIGNALING%WIKIPATHWAYS_20260211%WP437%HOMO SAPIENS EGF EGFR signaling MEF2C CAMK2A RPS6KA2 MEF2D GAB2 VAV1 NEDD4 VAV2 SRC SHC1 PDPK1 ERBB2 EIF4EBP1 SOS2 PTPN11 COX2 EGF INPPL1 CBLC RPS6KA5 GRB10 RPS6KB1 STAT5B PTK2B MAP4K1 MAPK9 MAPK8 STAT3 ARF6 MAP3K2 RAP1A CRKL INPP5D PIK3R2 PIK3R1 PTEN RAC1 JAK1 HRAS RALA EGFR PAK1 STAT1 BRAF MAP3K1 FOXO1 RPS6KA3 JUND MAPK1 KRAS ATF1 MAP2K1 MAPK14 MAP2K2 RAB5A RAF1 GJA1 PRKCB PRKCA PRKCI SPRY2 HEL-S-15 MAP2K5 PRKCZ CRK PLCG1 ROCK1 JUN MAPK7 CAV2 SP1 USP6NL SH3GL3 ERRFI1 MTOR NDUFA13 PLCE1 SH3GL2 STXBP1 RALBP1 PCNA CDC42 HGS STAMBP RIN1 STAM2 SH2D2A AP2A1 IQGAP1 FOXO4 PLD2 ATXN2 TNK2 PIK3C2B PTK6 CBL SYNJ1 AP2S1 RPS6KA1 HEL-S-34 PXDN NCK2 NCK1 VAV3 EPS15L1 FOS EPN1 AP2M1 PLSCR1 ARHGEF1 RALB CREB1 ASAP1 NEDD8 MAPK4 REPS2 RICTOR CSK LIMK2 GRB2 ITCH FOSB SOS1 PTPN5 SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260211%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260211%WP5601%HOMO SAPIENS Caffeine in blood vessels GUCY1A2 CALM1 PDE3B RYR2 ADCY3 ADRA1B MYLK ADCY1 ADORA2B ADCY8 ADRA1A PDE4A ADCY6 PDE3A RYR3 ADRA1D PDE4B PDE4D HEL-S-80p PPP1R12C ADCY9 ADORA2A NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2064%HOMO SAPIENS Neural crest differentiation ITGB1 HDAC2 HDAC10 HDAC11 DMBX1 ASCL1 CDH6 MPZ CDH2 ZIC1 MBP HOXA1 ID1 FOXD3 SNAI1 SOX5 MSX2 SNAI2 MIA BMP4 OLIG3 PAX3 ISL1 DCT OLIG1 PAX7 CTNNB1 OLIG2 HAND1 HDAC5 MYC SOX10 HOXB1 CTBP2 HDAC8 GFAP DLX5 HDAC9 TWIST1 HDAC7 HDAC6 PRTG GBX2 MSX1 TFAP2A MYB TFAP2B ZIC5 TBX6 NOTCH2 PHOX2B NOTCH3 GJB1 NOTCH1 TLX2 LHX1 PMP22 BMP7 LHX5 NEUROG1 FGFR2 HDAC1 HES1 TCF4 DVL1 HES5 FGF8A DVL2 DVL3 TCF7L1 NFKB2 COL2A1 WNT1 COL11A2 WNT3A GSK3B AXIN1 AXIN2 NFKB1 RBPJ SMAD1 FGF8 SOX9 FGFR1 RHOB FZD3 HEY2 FGF2 WNT8A DLL3 DLL4 HDAC3 FGFR3 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN1 GRIN2B DLG4 NLGN1 GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 NLGN3 NLGN2 NRXN1 PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260211%WP4971%HOMO SAPIENS Phosphoinositides metabolism PLCB4 PLCH1 PLCH2 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 PIP4K2A PLCG2 PLCG1 PIK3CA MTMR10 INPP5D PIK3R4 PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 MTMR9 MTMR4 STM7 PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260211%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit BCL2 IL2 SPN CD27 CD3G CD3E CD3D CD80 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260211%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM CHEK1 RAD9A CDKN2A CASP9 CASP3 BAK1 TP73 APAF1 BAX YAP1 MRE11A MDC1 TRAF6 RIF1 SMC3 KAT5 TRIM28 HSF1 RAD50 TP53BP1 RAD51 BLM ACTL6A RASSF1 NABP2 MCPH1 ATF2 FANCD2 PCNA PRKDC PARP1 H2AX MDM2 ATM NBN ATR SMC1A RNF8 BRCA1 TERF2 LATS1 BRCA2 RAD52 CDK5 CHEK2 RAD17 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260211%WP430%HOMO SAPIENS Statin inhibition of cholesterol production HMGCR FDFT1 PDIA2 DGAT1 APOA5 SQLE APOC2 APOC3 SOAT1 ABCG8 APOC1 ABCG5 CYP7A1 LIPC APOA2 ACSS1 APOA4 SCARB1 MTTP APOB LDLR PLTP APOE LPL ABCA1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260211%WP2882%HOMO SAPIENS Nuclear receptors meta pathway EP300 ACKR3 HGF CYP2C19 CYP3A7 NRG1 CYP3A4 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 AHR CYP4F12 ACOX1 CCND1 IL2 APOA5 GCC1 TNS4 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 MGST1 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 ABCB4 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 CYP1A1 SLC19A2 SLC2A3 GSTM3 PLK2 ABCC3 SMARCA1 SLCO1B1 HEL-S-128m SLC6A5 SLC6A7 ABCB11 SLC6A8 SLC6A9 DNAJB1 CPEB4 GSTM5 SLC6A1 SLC6A2 EPB41L4B ENC1 ANKRD1 TGFBR2 NCOA1 SLC2A14 FGFBP1 SERPINB2 EDN2 SLC2A11 NCOA6 EGFR SLC2A10 TSC22D3 SLC2A13 PTGS2 SLC2A12 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 BAAT POU5F1 SLC7A5 B3GNT5 CDC42EP3 AHRR PMP2 ANGPTL4 MFGE8 HBEGF NR1I3 FGD4 TNF SRPX2 GPR153 SERTAD2 CAP2 CCL20 CAVIN2 PTGES3 GSTM2 NR1i2 NR1H4 CYP8B1 KTN1 FASN FABP1 GSTA5 GSTA4 SLC27A5 GSTA3 SLC6A3 SLC27A1 CDC37 NR3C1 SLC39A9 UGT1A1 EPHA2 SLCO2B1 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 DNER SLC39A3 AIP ALDH3A1 FGF8A SCNN1A FKBP5 NFKB2 SLC26A2 ABHD2 IP6K3 DNAJC15 SLC2A9 ALAS1 SRXN1 SLC2A6 SLC2A7 SLC2A8 ARL5B CPT2 ZIC2 ME1 PDK4 POLK ACADM SRGN GPX2 HEL-S-25 HEL-S-22 TGFBR3 DNAJC7 NAV3 ADGRF4 BIRC2 BIRC3 SLC5A12 SLC5A10 PRRG4 UGT1A4 STOM UGT1A7 TXNRD3 S100P SPRY1 ADH7 PCK1 KLK15 FGF13 HSP90AB1 ABCC5 SRC DBI CCL2 APOA2 PLTP CDKN1B IL12B SMC1A IL12A IFNG GADD45B CDC2 IL17B TGFB1 STAT3 PPP1R14C BAX ALOX5AP TXN SERPINA1 THBD APOC3 CPT1A ABCG8 ABCG5 SCD CYP7A1 GPAM SULT2A1 CYP1A2 CYP1B1 NR0B2 ABCB1 BHLHB2 SLC2A2 SLC5A1 SLC5A2 SLC6A20 SLC5A5 PPARGC1A EGR1 UGT2B4 SLC6A19 UGT2B7 ABCC2 SLC6A18 GSTM1 SULT1A1 SNAI2 SLC5A8 FOXO1 CDK4 TNFAIP3 NR1C1 MYC IL11 RXRA JUND NR1i1 HEL-75 GCLC NFE2L2 CYP2C9 RGS2 CYP2A6 CYP2B6 EHHADH IGFBP1 HES1 JUNB SLC7A11 FTH1 NR1H3 SLC39A8 GSTM4 KAT2B KEAP1 MAFG SLC39A14 FTL CDKN1C JUN HMOX1 SP1 MAFF GCLM PDE4B AMIGO2 PTPA IL1B NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP61%HOMO SAPIENS Notch signaling GSK3B HDAC2 EP300 STAT3 SKP1 SRC NFKB1 MAML2 SNW1 MAML1 FHL1 DTX1 RBPJ MAGEA1 CIRSR MTOR SPEN PIK3R2 SAP30 NCOR1 NOTCH2 PIK3R1 HES6 NCOR2 NOTCH3 NUMB NOTCH1 APH1B FBXW7 ADAM17 MAML3 JAG2 PSEN2 HDAC1 PSEN1 HEY2 HES1 DLL3 HES5 DLL4 PSENEN ITCH LCK DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260211%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MARCHF5 DNAJC19 TIMM8A TIMMDC1 USP9X STAT2 PYCR2 GFER COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 C1QBP AIFM1 MCL1 TRAK1 MFN2 PARK2 VCP UFD1L MIPEP UBXN1 CLPB TXN2 PLEK FLJ10842 MICOS13 OPA1 OPA3 GDAP1L1 TXNRD2 LONP1 SACS PMPCB PMPCA UBXN6 PAM16 ATAD3A OXA1L PPA2 CLPP TMEM126A YME1L1 MICU1 HTRA2 SPG7 MFF TIMM50 HSPD1 PITRM1 MSTO1 MFN1 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260211%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 CDKN2A RELA ZAP70 IRF2BPL GRAP2 HLA-DRB1 TYK2 LTA PDPK1 LCP2 CARD11 BCL10 CCL19 MAPK1 PTPRC TNF HLA-DRA FYN MAPK3 CCL28 LAT RPTOR IL18R1 MAP2K1 NFKBIA DEPTOR CTLA4 MAP2K2 MLST8 BCL2L1 RAF1 CD80 RHEB IL12B IL12A IFNG IL23A PRKCQ CCND1 LCK IL17A GSK3B IL23R PIK3CD TSC2 MYD88 CD3G CD3E CHUK TSC1 CD3D BAX STAT4 IFNAR2 IKBKG PLCG1 IL12RB1 JUN NFATC1 IFNAR1 NFKB1 IL2 IL4 MTOR PIK3R1 ICOS FOXO3A FOS CDKN1A PTEN IFNB1 IKBKB PPP3CC RICTOR HRAS GRB2 SOS1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260211%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAG2 PRKAG3 PRKAA1 RHOB YAP1 RHO HMGCR CTGF PRKAB2 PRKAB1 LATS1 TEAD4 CYR61 PRKAA2 LATS2 ARHA STK4 TEAD2 RHOD TEAD3 MOB1A PRKAG1 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260211%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 ACE2 AGTR1 AVPR1B ENDOMETRIAL CANCER%WIKIPATHWAYS_20260211%WP4155%HOMO SAPIENS Endometrial cancer EGFR BAK1 NRAS BRAF CTNNB1 PDPK1 MYC AKT3 ERBB2 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 HEL-S-28 CTNNA1 CTNNA3 EGF RAF1 CTNNA2 FGFR2 LEF1 DDB2 PIK3R3 TCF7L2 TCF7L1 GADD45B GADD45G CCND1 GSK3B PIK3CD POLK CASP9 ARAF BAX AXIN1 AXIN2 PIK3CA BAD GADD45A APC PIK3R2 PIK3R1 FGFR1 FOXO3A FGF2 FOS CDKN1A PTEN HRAS APC2 GRB2 SOS1 FGFR3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260211%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK8 STAT2 MYD88 CHUK STAT1 TRAF3 TRAF6 TBK1 IFNAR2 IKBKG JUN TYK2 NFKB1 IFNAR1 MAVS RIGI MAPK14 NFKBIA TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 RIPK1 MAP3K7 FOS TICAM1 IKBKB JAK1 IFIH1 IRF3 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDKN2A EGFR SMAD2 SMAD4 PAK1 BAK1 RELA STAT1 BRAF VEGFA TGFBR1 RAD51 CDK4 AKT3 ERBB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 TGFA BCL2L1 EGF RAF1 RPS6KB2 dik RAC3 E2F2 RPS6KB1 DDB2 PIK3R3 RB1 PAK6 PAK4 GADD45B TIAM1 GADD45G CCND1 PIK3CD MAPK10 POLK CASP9 MAPK9 MAPK8 TGFB1 CHUK STAT3 ARAF BAX IKBKG PIK3CA NFKB1 ARHA BAD MTOR GADD45A PIK3R2 PIK3R1 RALBP1 CDC42 CDK6 E2F3 HEL-S-34 CDKN1A RALB BRCA2 IKBKB RAC1 JAK1 TGFBR2 RALA TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260211%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TDO2 IDO1 GOT2 IFNA6 KYAT3 KYAT1 IL6 DDC IFNB1 IFNG AADAT IL1B HAAO TNF KMO KYNU AFMID IDO2 HEART DEVELOPMENT%WIKIPATHWAYS_20260211%WP1591%HOMO SAPIENS Heart development MEF2C NKX2-5 SMAD4 FOXC2 FOXC1 VEGFA BMP4 SHH NFATC1 ISL1 PITX2 CTNNB1 FGF10 HAND1 GATA4 MAPK1 NFATC3 SMAD1 NFATC2 PTPN11 FGF8 NFATC4 ERBB3 NOTCH1 FOXA2 HEY2 BHLHB2 BMPR1A BMP10 GATA6 BMPR2 TBX20 SMYD1 TBX1 FOXH1 IRX4 TBX5 TBX2 HAND2 BMP2 VEGFB VEGFC SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4658%HOMO SAPIENS Small cell lung cancer ITGB1 LAMB3 LAMB2 PTGS2 BAK1 RELA TRAF3 CDK4 MYC AKT3 RXRA CDK2 NFKBIA NFKBIB BCL2L1 BCL2 CDKN1B ITGA2B E2F2 LAMC1 DDB2 CCNE2 PIK3R3 RB1 CKS1B CDKN2B GADD45B ITGA2 TRAF1 TRAF4 COL4A3 GADD45G CCND1 TRAF5 CKS2 CYCS RARB COL4A5 BIRC7 PIK3CD FHIT POLK RXRB CASP9 LAMA5 RXRG LAMB4 CASP3 CHUK APAF1 BAX TRAF2 TRAF6 IKBKG COL4A2 BIRC2 CDKN1C COL4A1 BIRC3 SKP1 COL4A4 PIK3CA COL4A6 NFKB1 MAX CASP8 NOS2 GADD45A PIK3R2 PIK3R1 LAMB1 CDK6 E2F3 LAMC2 CCNE1 ITGAV CDKN1A PTEN IKBKB ITGA6 LAMA1 LAMA4 LAMA3 EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer MMP9 MEF2D EZH2 SHC1 TWIST1 SOS2 PIK3R3 HIF1A COL4A3 COL4A5 MAPK8 SPARC TGFB1 TUSC3 HEL-S-79 FOXQ1 FZD10 CDKL2 CLDN3 CLDN9 CLDN7 PKP2 PKP1 EIF5A2 TWIST2 JUP PALS1 VTN NRP2 PKD1 CLDN22 CLDN20 CLDN24 CLDN23 EED CLDN11 CLDN10 CLDN15 PIK3R2 CTDSP1 PIK3R1 CLDN14 CLDN19 STRAP CLDN4 CLDN18 CLDN2 CLDN17 CLDN16 TMPRSS4 FZD1 NR2C2 WNT10B SUZ12 WNT10A GDF15 FZD3 NUBPL CRB3 FZD2 FZD5 FZD7 FZD9 FZD8 TJP1 MMP2 LATS2 HRAS TGFBR2 MMP15 SMAD2 SMAD4 PAK1 ID2 CDH2 FOXC2 ID1 SNAI1 FMNL2 SNAI2 FOXM1 TGFBR1 WNT7B WNT7A CTNNB1 CLDN1 AKT3 MAP2K3 MAP2K4 MAPK1 MAPK12 KRAS MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 RAF1 ZEB2 PROX1 WNT1 WNT3 WNT4 RBBP4 WNT3A GSK3B WNT2B PIK3CD TRAF6 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA LRP5 CLDN6 LRP6 RBPJ CLDN5 JAG2 FZD4 WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 GRB2 SOS1 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260211%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRB UQCC3 UQCC2 UQCR11 UQCR10 CYB TTC19 UQCRH UQCRQ LYRM7 UQCRC1 UQCRFS1 CYC1 UQCC UQCRC2 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260211%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MAP1B BIRC5 TUBA2 MYH9 ERG EGFR SMAD2 STUB1 MAPRE1 AURKA HEL113 CFTR HDAC11 ITIH4 EP300 NEDD9 HTT KALRN ATXN3 ADRBK1 EP400 CCDC141 SHH POU5F1 FUS BDNF MIIP TARDBP ARID3A ISG15 BBIP1 CTNNB1 GARS1 CNOT6 HEL-S-2a HDAC9 TWIST1 MAPK1 HDAC6 MAPK3 MAP3K5 HEL-S-44 CYBB BCL2 GRIA2 NR3C1 PXN PRKCE MAP1LC3A SQSTM1 OPTN HIF1A HEL-S-102 PTK2B HEL-S-32 MIF GSK3B DCTN1 PRKCZ MAPK8 RHOT1 MYD88 BAX PARK2 KAT5 VCP HSF1 CSNK2A2 FOXP3 TUBA1C DLG4 SP1 SGK1 CSNK2B VHL APC TUBB HEL-S-72p APOE TUBA4A HEL-S-67p GSK3A SNCA HSPA4 DLG2 RAC1 IKBKAP CDC20 FREP1 SNCAIP CD133 FAT10 SIRT2 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260211%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 EGFR PRL CHUK CEBPA PRLR NFIA CEBPB TFPI2 MYC CSN2 ERBB2 NRG1 CLDN6 YY1 ERBB4 DLGAP4 PTPN1 USF2 TTC9 NR3A2 GJB2 GAL ERBB3 NFIB ELF5 BCL2L1 EIF4E ORAI1 PGR HDGFL2 USF1 EIF4G1 TNFSF11 TPM3 NR3C1 TNFRSF11A STAT5B CCND1 TP53 NETWORK%WIKIPATHWAYS_20260211%WP1742%HOMO SAPIENS TP53 network BCL2 CDKN2A SUMO1 TNFSF10 TP73 BBC3 OTX2 BAX BOK MDM2 ATM CDKN1A MYC PMAIP1 GADD45A TP63 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 SP1 MAPK1 MAPK3 RBPJ TLR9 CYBB CDC42 NOTCH1 NCF2 DOCK6 CYBC1 NCF1 NOX3 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 KCNN3 C4orf54 DLL4 GTF2I BEND6 EFL1 CYBA SHCBP1 RAC1 IBTK ARHGAP31 EIF6 SBDS BTK TLR8 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260211%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease CALM1 KCNN3 SP1 SP3 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260211%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ADCY3 ADCY8 SLC16A10 SHH FOXO1 SRC KDM1A CTNNB1 AKT3 RXRA MAPK1 ATF2 RPTOR MAP2K1 MAPK14 MLST8 NOTCH1 RAF1 ITGB3 RPS6KA6 RPS6 RPS6KB1 RHEB AKT1S1 WNT4 THRA AQP7 GSK3B TRH TTF2 TTF1 NPPB ITPR2 MC4R CASP9 NHSL1 TSC2 DUOXA2 SLC16A2 TSC1 TBC1D4 TSHB ACTL6B SECISBP2L DIO1 SIRT6 SLCO1C1 ADRB3 PAX8 PIK3CA MAPKAPK3 ZNF516 PLIN1 PFKFB2 MGLL KDM3B AgRP UCP1 NR1A2 PRDM16 DUOX2 DEHAL1 NPY BAD MAFA FGF21 TSHR MTOR TG SLC26A4 TPO PNPLA2 POMC PPARG FGFR1 MDM2 ITGAV CREB3 FRS2 SLC5A5 PPARGC1A HRAS GRB2 SOS1 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260211%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAPK10 MAP2K5 MAPK9 MAPK8 RPS6KA2 CSNK2A1 PIK3CA AKT3 MAP2K3 EIF4EBP1 MAPK1 MAP2K4 MAP2K6 MAPK3 RPTOR MAP2K1 MAPK14 MTOR MAP2K2 PIK3R2 EIF4A2 PIK3R1 EIF4A1 PIM1 EIF4E PIM2 EIF4B RPS6KB2 EIF4G1 RPS6KA4 RPS6 RPS6KA5 RPS6KA1 RPS6KB1 PIK3R3 PRKCA THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260211%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling MAPK9 MAPK8 RELA STAT1 STAT3 RELB STAT4 GAB2 SRC NFKB1 EIF4EBP1 MAPK1 FYN MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA LYN MAP2K2 TEC YES1 IL7R TSLP FES CRLF2 RPS6 NFKB2 JAK1 STAT5B BTK LCK SPINA BIFIDA%WIKIPATHWAYS_20260211%WP5150%HOMO SAPIENS Spina bifida MAT1A MTRR MTR AHCYL2 MTHFD1 SHMT1 DNMT3B 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome SLC35G3 RPL23 SRCIN1 SLFN12 CACNB1 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 TCF2 SLFN5 CCL13 GRB7 CCL11 GGNBP2 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 CCL5 ERBB2 CCL7 ZNHIT3 LYZB C17orf78 CCL2 CCL4 CCL1 ASIC2 TEC CCL18 RFFL GAS2L2 SOCS7 ACACA CCL16 LHX1 HEATR9 CCL15 TAF15 TMEM132E RASL10B PCGF2 SYNRG EPOP FNDC8 PEX12 PLXDC1 NLE1 ARHGAP23 TBC1D3K STAC2 TCAP CDK12 SPMAP1 PIP4K2B PNMT PPP1R1B DHRS11 PGAP3 TBC1D3B CCL4L2 TBC1D3E TBC1D3C CWC25 PIGW TBC1D3I MRM1 AATF IKZF3 MMP28 CISD3 DUSP14 TBC1D3H CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 UNC45B MED1 CCL3 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome TLR4 HEL-S-130P PDX1 CTNNB1 MSRA GATA4 MAPK1 MAPK3 NKX6-1 SLC2A4 RAF1 BMP1 MTMR8 MTMR9 NUMA1 MTMR6 TERT PINX1 HEPACAM2 TBX5 SOX7 SLC35G5 PRSS55 NEIL2 BLK CSTA MCRS1 TNKS PRSS51 S100A10 DEFB136 C8orf74 DEFB135 DEFB134 RP1L1 MFHAS1 FAM167A FCGR2A FCGR2B AXIN1 XKR6 PPP1R3B FDFT1 CLDN23 SLBP ERI1 TERF1 SGPL1 CGAS HSPD1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5402%HOMO SAPIENS 10q22q23 copy number variation CEBPA VEGFA ERBB4 MGRA ADAM10 SMC1A MAT1A BMP2 SH2D4B FAM25A BUB1B SMC3 ADIRF LDB3 GHITM IQUB WAPAL NFKB1 ROPN1L RSPH6A ACTN2 SIRT4 DNAJB13 NME5 NRG3 CDHR1 MMRN2 SH3GL3 DYDC2 DYDC1 ZMYND11 RGR RSPH9 PDS5B PDS5A GPR15LG RAD21 SNCG TNFSF11 GPR15 PPARG SUSD2 RSPH3 GLUD1 MAD2L2 STAG1 TSPAN14 RSPH1 LRIT2 SHLD3 BMPR1A LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 OPN4 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA HEL-S-304 RPE PRPS1L1 DERA OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260211%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators MMP9 CNTF CXCL2 CCL14 CCL13 CCL23 CCL11 CCL3L3 LIF LTA CX3CL1 CCL8 CCL5 CCL19 CCL7 CCL28 CCL2 CCL4 CCL1 CCL18 CCL16 CCL15 IL25 IFNA6 IL12B TNLG7A IL12A IFNG IL23A IL17F IL17D IL17C IL17B IL17A IF2B1 IL15 IL-21 TGFB1 CXCL12 IL10 IL13 IL2 IL4 IL5 CXCL8 SPP1 IL3 IL9 CSF2 MMP3 IL1RN CXCL17 CXCL13 IF2D CXCL11 CXCL14 IF2G IL36A IL1A IL36B IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 EBI3 IL36RN IFNA21 IF1AA9 TNFSF13 IL36G PPBP VEGFA IFNW1 IL1F10 CXCL6 IL24 IF1IB1 IL27 CXCL3 IL7 IFNA8 CSF1 PF4V1 IL11 IL19 XCL2 TNF IFNK XCL1 CTF1 IFNL2 IFNL3 CCL17 CCL20 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 IFNA7 OSM CSF3 EPO NFKB1 IL6 IFNA2 CXCL5 TSLP CXCL16 CCL4L2 IL18 IFNB1 IL1B CXCL9 IFNA1 CXCL1 AREG CCL3 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260211%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis BCL2 FADD CASP9 CASP3 BAK1 APAF1 DIABLO BAX TNFSF6 CASP6 PRF1 FAS HTRA2 CASP8 AIFM1 CYCS TRANSLATION FACTORS%WIKIPATHWAYS_20260211%WP107%HOMO SAPIENS Translation factors EIF1AX EEF2 EIF2S2 SUI1 EIF3S3 EEF2K EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3B EIF4EBP1 EIF4A2 EIF4A1 EIF4E EIF4B EIF4G1 GSPT2 EEF1B2 EIF4H EIF4EBP2 EIF4EBP3 EIF2AK2 EIF2B1 PAIP1 EIF5A EIF5B EIF2B3 CLUH EIF2B2 EIF1AY EEF1A1 EEF1G EIF2AK1 EIF6 EEF1A2 EIF2B5 ETF1 EIF2S1 PABPC1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT3 MTOR 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260211%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression EIF4E PIK3CD RAF1 TSC2 PRKAA1 TSC1 PIK3CA PIK3R3 MAP2K3 EIF4EBP1 MAPK1 MAP2K6 MAPK3 MAP3K5 MAP2K1 MTOR MAP2K2 HEL164 PIK3R2 MAP3K11 PIK3R1 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260211%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 H3Y2 DUX4 MYF5 EP300 VEGFA PAX7 TRIM63 ADRB2 CDKN1A MYC FBXO32 PPARGC1A NR3A2 MYOD1 MYOG RET H3Y1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2853%HOMO SAPIENS Endoderm differentiation TAF5 MIXL1 HOXA1 EZH2 PAX3 RGS10 CTBP2 GATA4 ZIC5 LHX1 ELAVL1 SESN1 LAMC1 GATA6 TCF4 C1QBP FOXH1 SOX7 PLCH1 APP TGFB1 TBX21 CRTC1 PIAS1 NABP2 DKK1 DNMT3B MAD2L2 BMPR1A NKX2-1 CAND1 SIAH2 SMAD2 SMAD4 SLC2A12 STAT1 TET1 TCF2 FOXO1 POU5F1 SFRP1 CUL4B CTNNB1 MAP2K3 SOX2 FOXA1 NOTCH1 ACACA BMP7 OTX2 FOXA2 NR3C1 LEF1 PTHLH TCF7L1 WNT3 PABPC1 WWC1 SOX21 SOX17 CEP250 CER1 WDHD1 SFMBT1 CDYL EMSY RFX7 RAB38 WDFY2 HPRT1 BCORL1 TOX CTR9 PRDM14 RTF1 NLK MBTD1 EPB41L5 UBR5 BPTF CEBPZ ATP8B2 PBX3 FOXN3 GDF3 DUSP4 APC ZFHX4 TRERF1 PBX1 EXT1 SP4 PAF1 TAF4B NODAL TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 JARID2 DUSP5 VAV3 DUSP2 WNT8A NOG PARP8 NR1B3 TOX3 AEBP2 Pax9 AHDC1 BTAF1 TCEAL2 LEO1 KDM4A ZNF462 ELP4 LRPPRC TNRC6C ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor pathway PLAGL1 EGFR CD36 KLF6 NCOA7 PTGS2 RELA EP300 NRAS VEGFA SRC NFKB1 AHRR MYC CDK2 MAPK1 TNF KRAS FGF21 CCL1 MAP2K1 NCOR2 GCLC RAF1 NFE2L2 CDKN1B LPL NQO1 CYP1A2 NF1 CYP1B1 CDC37 CYP1A1 AIP CDKN1A RB1 HRAS AHR RET GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260211%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG INS IL6R IL6 GLP1R SLC2A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260211%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP INSR STAT3 LEPR INS PDPK1 PIK3R3 SOCS2 DGKZ SOCS3 SOCS1 IRS1 IRS4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260211%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 REN MGRA ACE2 AGTR1 DRAVET SYNDROME%WIKIPATHWAYS_20260211%WP5200%HOMO SAPIENS Dravet syndrome CAMK2A SCN8A PRR5 MAPKAP1 KCNA2 CHD2 PCDH19 SCN3B SCN3A SCN1B SCN1A PIK3CA SNTA1 NFKB1 SCN2A SCN4B SCN2B HCN1 TNF MAPK11 MTOR STXBP1 MLST8 CALM1 FGF13 PRKCA RICTOR S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260211%WP26%HOMO SAPIENS S1P receptor signal transduction PLCB1 PLCB2 GNAI1 S1PR3 PIK3C2B GNAI3 SPHK2 SPHK1 MAPK7 PLCB3 AKT3 MAPK6 SMPD2 MAPK1 S1PR2 MAPK4 MAPK12 S1PR5 MAPK3 S1PR1 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260211%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome MEF2C CAMK2A TET2 CNP CTCF TET1 MBP EZH2 IGF1 FUS IGF1R CEBPD BDNF TARDBP GRIN1 DLX5 PSIP1 YBX1 CDON RBFOX1 HEL-S-20 TAP1 NCOR1 POU3F2 HNRNPH1 GPRIN1 TET3 DLX6 FOXG1 NREP FUT8 PRPF38A RPS6 GAD1 HDAC1 GRIA3 IGF2 GRIA4 POU4F1 SST HNRNPF TAF1 FKBP5 REST SP3 BCL6 MYT1 SMC3 UBE3A SP1 SGK1 APOC2 MTOR OPRK1 NF1 FGF2 FGF7A PTEN CREB1 FGF5C SIN3A CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway CYP51A1 SC5D DHCR7 HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260211%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB COL5A3 COL5A2 LAMB2 COL3A1 ITGB5 COL4A2 COL4A1 LAMC1 ITGB6 THBS1 SDC2 ITGA1 COL6A1 LAMA4 COL1A2 THBS2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260211%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling GSK3B PDHA1 CYP24A1 TSC2 TSC1 RELA CD80 IL10 SLC2A3 PIK3CA IL12A MYC PFKFB4 HEL-S-133P RXRA PRKAA2 NR1i1 HK3 HLA-DRA MTOR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260211%WP4747%HOMO SAPIENS Netrin UNC5B signaling CIP2A RGMA DCSTAMP MYF5 COL1A1 CASP3 YAP1 CTGF IL10 JUN NEO1 SRC PIK3CA KDR AGAP2 MAPK1 TNF ARHA FYN MAPK3 INPP5D CCL2 PTPN11 MAP2K1 MAPK14 MAP2K2 SELE PPP2R1B RAF1 ALPL ITGB4 PRKCA PTPA RAC1 ROBO4 NTN1 PTK2B RLF NTN3 PLEKHH1 ARHGEF12 VCAM1 UNC5B IL1A HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260211%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260211%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex HLA-DRB5 NRF CD8B1 CD3G PRG3 CD3E CD2 IGLL1 CD8A CRP LBP ZAP70 MMP25 HLA-DRB1 IL6 CXCL8 HLA-DRA FYN LCK FANCONI ANEMIA%WIKIPATHWAYS_20260211%WP5465%HOMO SAPIENS Fanconi anemia EGFR MRE11A DCLRE1B CTDP1 UHRF2 FAAP24 CEBPD BRIP1 RAD50 SLX4 RAD51 MEN1 FANCM CENPX FANCL REV1 UBE2T FANCA FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C FANCD2 RFWD3 ERCC1 HEL-S-125m CENPS MCM2 SMARCA4 FAN1 MAD2L2 ATM NBN ATR UHRF1 PTEN BRCA1 BRCA2 USP1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260211%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling IRAK1 PDLIM7 MAPK8 CHUK RELA TRAF6 IKBKG MAP3K7 NFKB1 TRADD NFKB2 IFNB1 CXCL8 IKBKB CCL5 MAPK1 TNF MAP3K14 TRAF1 NFKBIA CCL20 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260211%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 PCNA MAFG FBL CREBBP IRF2 SMAD4 HEL23 DDX21 CREB1 FOXO1 NPAS2 P38 MAPK SIGNALING%WIKIPATHWAYS_20260211%WP400%HOMO SAPIENS p38 MAPK signaling MEF2D STAT1 TRAF2 MAP3K1 TGFBR1 SHC1 MAX MYC MAP2K4 DDIT3 MAP2K6 MAP3K5 ATF2 MAPK14 SMIM40 CDC42 RASGRF1 HMGN1 MAPKAPK5 RPS6KA5 RIPK1 MAP3K7 TRADD CREB1 RAC1 HEL-S-102 HRAS GRB2 MAPKAPK2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHS1 ACSL5 ACSL3 ACACA FASN PECR MECR PC ACSS2 ECHDC1 ECHDC2 DECR1 ACLY ACACB SCD ACSL1 ACSL6 FACL4 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260211%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway MASP2 HEL-S-62p C3AR1 FCN1 C6 C7 COLEC11 C9 ACE2 C5AR1 C8A ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP IL2RG CRLF2 STAT3 IL25 FCER1G IL13 IL1RL1 FCER1A TYK2 MS4A2 IL13RA1 IL4 IL5 OSMR JAK3 IL33 METHYLATION PATHWAYS%WIKIPATHWAYS_20260211%WP704%HOMO SAPIENS Methylation pathways MAT1A NNMT TPMT INMT PNMT METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer ME1 BCAT2 HMGCR PFKL ACLY SLC7A5 DLD SOAT1 KRAS HEL-S-30 HK2 GNPNAT1 PDHA1 LDLR GOT2 FASN CS GLUD1 PDHX RPIA GLS2 RPE PGM3 HEL-S-133P DLAT GPT SLC16A4 CARM1 HEL-S-32 GFPT1 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260211%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA HEL-S-304 RPE HEL107 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260211%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAG2 PDHA1 ACACA FASN PRKAG3 PRKAA1 LIPE PRKACG ACSS2 PRKAB2 ACLY PRKAB1 HILPDA PLIN1 AKT3 PRKAA2 PRKAR1B PRKAR1A ABHD5 PNPLA2 PRKAG1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260211%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TLR4 IRAK4 IL2RG TGFB1 STAT3 CD80 TRAF6 NFKB1 IL4 NFKB2 SOCS1 CCL5 CCL2 TGFBR2 CTLA4 IL2RA TLR8 TLR7 IL2RB PDCD1 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260211%WP5572%HOMO SAPIENS Nucleosome remodeling complex PCNA PRKDC CHAF1B NASP MCM2 HAT1 ASF1A ASF1B H4C9 HIST1H4L CHAF1A RBBP4 SUPT16H XRCC5 SMIM40 SSRP1 CHEK2 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260211%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 CYP2A6 XDH CYP1A2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260211%WP4666%HOMO SAPIENS Hepatitis B infection TLR4 MMP9 IRF7 CREBBP STAT2 EP300 EGR2 SRC TYK2 SOS2 NFATC3 NFATC2 NFATC4 IKBKE IFNA6 MAP3K7 DDB2 PIK3R3 STAT5B PTK2B JAK3 MAPK10 MAPK9 MAPK8 TGFB1 STAT3 ARAF BAX STAT4 NFATC1 CXCL8 CASP8 VDAC3 PIK3R2 PIK3R1 FADD IKBKB CASP12 JAK1 HRAS IFIH1 TGFBR2 IRF3 TLR3 IFNA13 BIRC5 IFNA14 IFNA16 SMAD2 IFNA17 SMAD4 IFNA10 TICAM2 HSPG2 RELA STAT1 IFNA21 DDX3X TRAF3 IF1AA9 CASP10 BRAF TIRAP NRAS DDB1 MAP3K1 TGFBR1 MAP3K7IP1 FAS MYC IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 KRAS MAP2K6 MAPK3 MAPK13 ATF2 MAPK11 MAP2K1 MAPK14 MAP2K2 BCL2 RAF1 CREB3L3 CREB3L4 TNFSF6 PRKCB IFNA7 TICAM1 PRKCA CYCS ATF4 IRAK1 PIK3CD IRAK4 CASP9 MYD88 CASP3 CHUK APAF1 TRAF6 TBK1 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD PCNA YWHAQ HEL-S-1 CREB3L2 FOS YWHAZ CREB3 CDKN1A IFNB1 CREB1 CREB5 IFNA1 GRB2 SOS1 ATF6B NEPHROTIC SYNDROME%WIKIPATHWAYS_20260211%WP4758%HOMO SAPIENS Nephrotic syndrome COL4A5 MYH9 LAMB2 MYO1E SCARB2 SMARCAL1 CD151 HEL-S-47e PTPRO COL4A4 GPC5 APOL1 TRPC6 SYNPO YARS EMP2 ALG1 WDR73 COQ6 ARHGAP24 COQ2 PAX2 WT1 CD2AP INF2 NPHS1 CTLA4 CYP11B2 PLCE1 ACTN4 NPHS2 COQ8B LMX1B E2F3 ITGB4 ZMPSTE24 LMNA CUBN COL4A3 INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260211%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 THRAP3 MORC3 ELL BCLAF1 SETX STK38 TRIM35 RBBP7 SUZ12 EZH1 EZH2 JARID2 AEBP2 RBBP4 EED COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260211%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation F2 HEL-S-78p F13B PLG F13A1 FGA BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260211%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260211%WP5236%HOMO SAPIENS Markers of kidney cell lineage TNC REN TCF2 BMP4 SFRP1 DKFZp781O1323 KDR PAX2 WT1 RSPO1 NPHS1 NPHS2 NOTCH2 NOTCH1 LHX1 HNF1A tmp_locus_29 BMP7 NR2A1 CITED1 TCF21 SALL1 SIX2 RSPO3 DACT1 EMX2 FOXD1 OSR1 KCTD1 ALDH1A2 PECAM1 TSHZ3 EGLN1 EGLN3 KIT EGLN2 EYA1 WNT4 TBX18 NTN1 GDNF TLX1 FAT4 DCN VSX2 ACTA2 EPO AXIN2 SIX1 SMAD1 FGF7 FGF8 PBX1 NT5E IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 IDO1 GOT2 IFNG AADAT TNF KMO KYNU KYAT3 KYAT1 IDO2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260211%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 CYP1A2 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260211%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF PGR FOSL1 MYC HEL113 ERBB2 CCND1 TIMP1 AREG HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC RBX1 CBFB NAE1 UBA3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260211%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B PTPRN CAMK2A SCN11A PDCD10 SCN7A SCN8A SCN5A PRRT2 MAPK8IP2 SCNM1 SCN4A RNF121 NEDD4 SCN3B SCN3A WEE1 SCN1B SCN1A SCN2A SCN4B SCN2B TNF FYN FGF14 CALM1 FGF13 FGF12 PSEN1 SCN9A BACE1 SCN10A ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260211%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260211%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC5 CDKN2A BAK1 TRAF3 CASP10 FAS MAPK3 MAP3K5 NFKBIA BCL2L11 SMIM40 BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO PIDD1 TNFSF6 CASP6 RIPK1 AIFM2 IL1R1 PMAIP1 TNFRSF10B AIFM1 BLK PRKD1 MCL1 CYCS IRAK1 BIRC7 TNFRSF10A CASP9 MAPK8 MYD88 CASP3 APAF1 BAX TRAF6 HRK TNFRSF6B BIRC2 CAPNS1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 PTRH2 MADD TNFRSF25 NAIP BCL2A1 BCL2L10 CASP8 BAG3 MAP3K14 BMF CRADD BAD BIK BNIP3 TNFRSF10C SEPTIN4 PTPN13 TNFRSF10D BCL2L2 FADD FOS TRADD IKBKB TNFRSF1B HTRA2 IL1R2 NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP268%HOMO SAPIENS Notch signaling CREBBP HDAC2 CTBP2 MAML1 DTX1 RBPJ NOTCH2 NCOR2 NOTCH3 NUMB NOTCH1 APH1B ADAM17 MAML3 RBPJL JAG2 CTBP1 DTX2 DTX3 PSEN2 DTX4 LFNG KCNJ5 HDAC1 DTX3L PSEN1 KAT2A MFNG HES1 DLL3 DVL1 HES5 DLL4 DVL2 DVL3 KAT2B METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260211%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX12 PTGS2 ALOX5 ALOX15 FADS2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260211%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDK2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 RPTOR MAPK11 MAP2K1 MAPK14 MAP2K2 PRKAG1 MLST8 PRKAG2 PRKAG3 PRKAA1 PRKAB2 RPS6KB1 PRKAB1 CDC2 EEF2 EEF2K MTOR CALM1 UQCRB COX7C RPS6KA1 RAB5IF MOSMO UQCR11 NDUFS8 UQCR10 CYB NDUFS3 COXFA4 CDH18 UQCRH COX5A UQCRQ TRPM7 UQCRC1 PDZD9 UQCRFS1 CDR2 CYC1 NDUFA9 SDR42E2 UQCRC2 VWA3A POLR3E FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260211%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 RPS6KB2 TSC2 FSHR RPS6 RPS6KB1 FOXO1 RHEB SRC PRKCA FSHB CREB1 EIF4EBP1 MAPK1 SGK1 MAPK3 H3-4 APPL1 MAPK14 MTOR CGA PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling MMP9 BIRC5 PTGS2 RELA CHUK CXCL2 RELB TRAF6 VEGFA BIRC2 BIRC3 TNFRSF1A NFKB1 IL2 IL6 CXCL8 BCL2A1 TNF SELE BCL2L2 NFKB2 CD40LG IKBKB EGLN2 MMP2 IL1B CSF2 MMP3 REL CCND1 VCAM1 IL1A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260211%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway CYP2C8 NR1C1 PPARG CYP4F2 CYP4A11 CYP4F12 CYP2C18 EPHX2 CYP4A22 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260211%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C2 NR1C1 CD36 CYP2C9 NR1i1 NPC1L1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260211%WP2636%HOMO SAPIENS Common pathways underlying drug addiction CAMK2A ADCY1 ADCY8 GNAI1 ARAF PPP1R1A GRIN1 PPP1CC RAP1A HEL-S-80p MAPK1 MAPK3 GNAS MAP2K1 MAP2K2 GJB1 CALM1 RAF1 ACTG1 GRIA2 GRIA3 PS1TP5BP1 PRKACG GRIA4 PRKCB PRKCA DRD1 DRD2 CREB1 DRD4 ACTG2 CAMK4 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 UGT2B7 AKR1D1 AKR1C1 AKR1C4 AKR1C2 UGT1A10 CYP11B2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260211%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PLCB4 PLCB1 CACNA1A PLCB2 GRIA2 GNA14 RYR3 HOMER3 CA8 GRIA3 GRIA4 GNA11 TRPC3 GNA15 PLCB3 ATP2B2 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260211%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy PPP3R1 NFKB1 TGFB1 RASGRF1 STAT3 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260211%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling GSK3B MAPK9 MAPK8 CASP3 RELA CHUK TRAF3 RELB TRAF2 BIRC2 BIRC3 JUN NFKB1 CTNNB1 MAPK1 TNF CASP8 MAP3K14 MAPK3 MAPK14 NFKBIA NFKBIB FADD RAF1 HDAC1 RIPK1 MAP3K7 TWEAK TRIM63 TNFRSF12A NFKB2 IKBKB RAC1 TRAF1 TRAF5 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260211%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP9 SMAD2 CACNB1 SMAD4 MCUB SCX TOMM20 SLN TGFBR1 SGCA CAPN3 TRPC1 TRDN STIM1 CASQ1 TNNI1 DMD CACNG1 PRKAA2 PLA2G2A TNF FKBP1A SSPN SNTB1 NFKBIA AGTR1 CYBB ORAI1 PPIF CACNA2D1 PRKAA1 MPO CACNA1F FGA HEL-S-78p CACNA1S MCU DAG1 ATP2A1 ITPR2 CASP9 TGFB1 PRG3 CTGF IL10 TRPC6 SLC25A5 NFKB1 TRPC3 IL6 SPP1 NOS2 ELANE RYR1 SIGMAR1 NOX4 MMP2 IL1B CAMK2D TGFBR2 IL1A CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260211%WP2023%HOMO SAPIENS Cell differentiation expanded index MEF2C TLX2 MEF2B KLF4 ID2 MEF2D STAT3 RUNX2 EZH2 PAX7 HDAC5 LEFTY1 TLX1 SOX2 TLX3 MYOD1 LEFTY2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260211%WP3972%HOMO SAPIENS PDGFR beta pathway RAF1 MAPK8 STAT1 STAT3 MAP3K1 PLCG1 JUN PRKCB EIF2AK2 PIK3CA SHC1 FOS PRKCA MAP2K4 STAT5B MAPK3 JAK1 HRAS MAP2K1 GRB2 SOS1 PIK3R1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260211%WP4150%HOMO SAPIENS Wnt signaling in kidney disease WNT2B MAPK10 MAPK9 MAPK8 WNT7B WNT16 WNT7A CTNNB1 LRP5 LRP6 ARHA INVS WNT5B NPHP3 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 WNT9B FZD7 FZD9 FZD8 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260211%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 CDKN1A ID2 ARCN1 ID1 USP1 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260211%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia GSK3B FLT3 ZBTB16 PYGO1 BCL9 WIF1 SALL4 RARA RUNX1T1 LEF1 PML CSNK1A1 AXIN2 NR1C2 JUP CTNNB1 TCF3 DKK1 MYC LRP5 WNT1 LRP6 CCND1 APC SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260211%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK GPX2 RELA DIO1 JUN NFKB1 TXNRD3 SP1 GPX1 CTH FABP1 NFE2L2 RPL30 HEL-S-134P SELENOF GPX3 SELENOI TXNRD2 SELENOH SEPHS1 CREM SEPHS2 PSTK EEFSEC POU2F1 GPX6 FOS TRNAU1AP SELENOO SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SELENOW GPX4 SELENOV SELENOT SP3 MSRB1 SELS HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260211%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias FECH UROD UROS HMBS CPOX ALAS1 ALAS2 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5366%HOMO SAPIENS NF1 copy number variation syndrome EGFR ADAP2 HOXA1 MAP3K1 RAD51 OMG MAPK1 MAPK3 SUPT5H BCL2 EGF CRY1 RAF1 RBBP7 EZH1 CCNA2 CCNE2 SDC2 MCL1 PER1 RTN4R HEL-S-15 RAD9A WDR48 NGFR HOXA9 H3C8 EXOC8 EXOC7 RFC2 MYT1 ARF6 POLRMT EXOC4 EXOC3 MAP3K2 EXOC6 ROCK2 RFC3 EVL RFC4 EXOC5 EXOC2 EXOC1 H3C15 INPP5A E2F6 RAB11FIP4 TEFM UTP6 LIMK1 MAVS ATAD5 ARHA RAB11A RIGI EED COPRS EVI2A CRLF3 EVI2B METAP2 PCNA TUBB SUZ12 NF1 CCNE1 JARID2 H4C9 ATR HIST1H4L NGF IFNB1 USP1 SYN1 SOS1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260211%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAB1 LEP ACACA ADIPOR1 ADIPOR2 PRKAA1 CPT1A LEPR PRKAG1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260211%WP2361%HOMO SAPIENS Gastric cancer network 1 NUP107 NOTCH1 HCTP4 GATD3 KIF15 AURKA SMOC2 CENPF ESM1 RUVBL1 MYBL2 ECT2 KIF20B E2F7 TOP2A H4C9 UBE2C ACTL6A S100P CEP192 H3F3B LIN9 APC INO80D VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260211%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins F2 F7 PROC AIFM2 NQO1 PROS1 VKORC1 UBIAD1 F10 F9 GGCX PROZ 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5406%HOMO SAPIENS 13q12 12 copy number variation DAG1 MAPK9 MAPK8 TRAF3 TRAF2 SGCA SNTA1 LINGO1 DMD ARHA SSPN SNTB1 CDC42 MIPEP SACS RTN4 C1QTNF9 SGCD ATXN1 SGCB SGCG TNFRSF19 C1QTNF9B SPATA13 RAC1 TRAF1 TRAF5 RTN4R TNF ALPHA SIGNALING%WIKIPATHWAYS_20260211%WP231%HOMO SAPIENS TNF alpha signaling CREBBP NRAS MAP3K1 MAP3K7IP1 KSR1 TNFAIP3 SMPD2 MAP2K3 MAP2K4 MAPK1 TNF KRAS MAPK3 MAP2K6 MAP3K5 NFKBIA RFFL NFKBIB BCL2L1 RAF1 DIABLO CDC37 MAP3K8 RIPK3 MAP3K7 RIPK1 NFKB2 CYBA REL TRAF1 PPP2CA TANK CASP9 PRKCZ MAPK9 TAB3 PIG59 MAP4K2 MAPK8 CASP3 CHUK APAF1 BAX TRAF2 TBK1 IKBKG BIRC2 BTRC BIRC3 SKP1 JUN CSNK2A1 TNFRSF1A TXN NFKB1 MADD CASP8 MAP3K14 FBXW11 BAD PSMD2 PLK1 FADD TRADD IKBKB TNFRSF1B OTUD7B RAC1 PYGL HRAS KSR2 PTPRCAP NSMAF GRB2 NFKBIE SOS1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence CYP4F8 SLCO2A1 HEL-S-53e DPEP2 ALOX12 LTC4S NAT2 PTGS2 ALOX5 HEL-S-22 ALOX15B ALOX15 ALOX5AP GPX1 FADS2 MAPK11 EPHX2 PTGES3 FADS1 ELOVL5 SIRT1 HEL-S-298 HPGD AKR1B1 DECR1 PTGS1 CDKN1A RB1 PTGIS PRXL2B ALOXE3 ELOVL2 PTGES PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway WNT2B TF NTF4 FST CNTF FLT3LG KITLG TGFB1 INHBA GDF5 EPO PDGFA IGF1 VEGFA BMP4 SHH WNT7B ALK INS FGF10 CSF1R HGF DKK1 IL6 CSF1 IL11 LEFTY1 FGF8 TPO IL3 NOTCH1 EGF TNFSF11 NODAL FGF2 FGF7A NOG IL6R WNT1 KIT NT5E CXCR1 WNT3A FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260211%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling IRAK1 TLR4 IRAK2 IRAK4 MYD88 TICAM2 RELA CHUK LY96 LBP TIRAP TRAF6 IKBKG SRC PIK3CA NFKB1 CXCL3 IL6 TNF ARHA NOS2 CCL2 SYK ITGAM PLAT PLG FGA IL12B FCER1G TICAM1 HEL-S-78p IFNB1 IKBKB REL TYROBP IRF3 CD14 TLR3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260211%WP5173%HOMO SAPIENS Disorders of galactose metabolism SLC5A1 GYS2 GYS1 HEL-S-19 PYGL AKR1B1 SLC2A2 GYG1 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260211%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BIRC5 SMAD2 SMAD4 PTGS2 BAK1 DCC BRAF MSH3 TGFBR1 CSNK1A1 CTNNB1 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 BCL2L11 BCL2 RAF1 BBC3 LEF1 RAC3 DDB2 TCF7L2 TCF7L1 PMAIP1 REL GADD45B NTN1 GADD45G CCND1 CYCS GSK3B MAPK10 POLK CASP9 MAPK9 MAPK8 CASP3 TGFB1 ARAF BAX AXIN1 TBK1 AXIN2 MSH6 JUN MSH2 EXOC2 ARHA BAD GADD45A APC CSNK1A1L FOS CDKN1A RALB RAC1 APPL1 APC2 TGFBR2 RALA PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260211%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function GUCY1A2 CAMK2A PDE3B ADCY3 ADCY1 ADCY8 PDE4A ADCY6 PDE3A GUCY1B1 PDE1C PDE1B PDE1A HEL-S-7a GRIN1 PDE11A PPP1R1B PDE6D PDE6C PDE6A PDE8A PRKG1 PDE6H PDE6G PDE2A PDE10A PDE12 PDE5A PDE7B PDE7A ADORA2A PDE9A CHRNA7 PDE4B PDE4D GRIN2B DRD1 DRD2 CREB1 ADCY9 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260211%WP1422%HOMO SAPIENS Sphingolipid pathway CERS5 PLPP1 ACER1 SPTLC3 CERS2 SERINC1 CERT1 ASAH2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 GBA2 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 PPP2CA KDSR VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260211%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling CREBBP HLX TRPC1 KDR HEL-S-68p GATA2 ACKR3 PDPK1 PRKAA2 SHC2 MLST8 VPS39 EIF4E TPM3 ADAM10 RPS6 NCL RPS6KB1 PTMAP7 PLA2G5 PXN AKT1S1 ACACB SARS1 CAMKK2 SDCBP PTK2B CCND1 OCRL TBCA EIF3S3 HEL-S-162eP NFATC1 EIF3F EIF3D DKK1 RAP1A CXCL8 CYR61 RAB11A MMRN2 PIK3R2 PIK3R1 RAPGEF1 FADD MDM2 HEL-S-128m NOX4 TEAD4 PPP3CA MMP2 RAC1 HRAS ANXA1 MMP10 SLC2A14 MMP14 ABCF2 PAK1 PTGS2 RELA STAT1 VEGFA FAS CTNNB1 HMGB1 HBEGF MAP2K3 PRKG1 MAP2K4 MAPK12 MAP2K6 MAP3K5 GPX1 MAP2K1 MAPK14 MAP2K2 CYBB RAB5A ERN1 BCL2L1 ACACA RAF1 RPL5 HEL114 RPL7 RPL18A LUC7L UBAP2L CHAC1 EPHA2 EPHB2 RPS11 FGA IER5 EIF2A ACOT9 TMEM170A SND1 INPP4B HEL-S-78p hEMMPRIN KATNAL2 EWSR1 BIN1 TXNIP ALB RPL27 PRKD2 PRKCI RPL26 PPP2CA PFN1 PABPC1 EZR HEL164 ATP6V0D1 MAPKAPK2 CYCS FLII GIGYF2 GSK3B HEL-S-15 DHX36 XB MYO6 MICAL2 PRRC2C LARP7 SRPK1 CALU HYOU1 DHX29 FAF1 KCNC3 CRK CCDC124 ROCK1 SRP54 ROCK2 HBD SHB EEA1 PIK3CA CSRP2 TMSB4X RPLP2 CGNL1 SSR4 SSR3 FJX1 LIMK1 ENG ARHA KANK1 HEL-S-87p CRIP2 SLC7A1 MTOR APOLD1 FGD5 GPC1 FLNB NUMB CDC42 CCT7 BRD4 AAG1 PRKRA TFAM TAOK2 COPG1 FOXO3A GLUD1 FHOD1 ITGB5 CTNND1 PLOD3 RPL10A AMOT CBL EPRS1 tal-1 CCRL2 P4HA2 TMSB10 ITGAV DUSP5 TMOD1 TMOD3 SEMA6D DPM1 FARSB DOK1 DLL4 ARMCX1 RAB37 ADAM9 FRS2 ZNF555 DSC1 LRRC59 HTRA1 FUT1 GRB2 QK3 IGFBP7 ZC3H15 HEL-S-94n SDF2L1 MEF2C HEL-S-84 BMX TPP1 ITGB1 AFDN RCAN1 TFCP2 CNP NR4A3 SPIRE1 GRSF1 MAPKAP1 C15orf39 FHL2 NRARP LDB2 VAV2 RND1 SET CAPZB LRRFIP2 ADAMTS9 SRC SHC1 ARHGEF15 SHROOM2 RPL13A HDAC5 SLC25A11 PPM1G HDAC9 DNAJB4 HDAC7 FAM120A DNAJB9 FYN WASF1 NFATC2 CCL2 SLC25A25 PTPN1 PDE4DIP PTPN11 NFKBIA CDC42BPB FMNL3 PTPN9 PTPN6 CTNNA1 ITGB3 RPS6KA5 GRB10 BMP10 ELOA HEL-S-133P RAB4A PLAUR MAPK9 MAPK8 STAT3 ARF6 CTGF TXN MYO1C HEL-S-99n TUBB8 TUBA1C TRPC3 NRP2 PSMD4 FBXW11 F3 SELE LMAN1 MAPKAPK5 PSMD11 DECR1 SIAH2 EGR1 HEL107 ATP6V1E1 CYP2C8 BIRC5 KL MYH9 ERG TRAF3IP2 FLT1 FOXO1 HEL-S-2a PNP MAPK1 MAPK3 ATF2 HEL2 BCL2 SLC8A1 ACTG1 EIF4G1 CACNA2D1 PRKAA1 GJA1 HDAC1 NCF1 PRKCB PRKCE FXR2 PRKCA HEL-S-102 MYL2 PRKD1 BMP2 ATF4 ELOC MOV10 PRKCZ PLCG1 JUN ARF4 NFKB1 TNFRSF25 NAPA TNFRSF10C SH3BGRL3 CLTC HGS SH2D2A AP2A1 NCF2 IQGAP1 ARRB2 FOXO4 AP2S1 SYNJ1 NCK1 EPN1 ADRB2 PLCB3 CREB1 RICTOR CSK S1PR1 ITCH NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260211%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 AGTR2 REN ACE2 AGTR1 CYP2R1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HEL-S-53e HAT1 HDAC2 HDAC10 DHFR ADH1A HDAC5 HDAC8 ADH1C HDAC9 HDAC7 HDAC6 ATF2 HEL-S-117 ALDH2 SLC19A1 ALDH1A3 MTR HDAC1 ACSS2 TYMS CYP2E1 MAT1A ALDH1A2 HDAC3 KAT2B SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260211%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 TRAF3 IF1AA9 TBK1 IFNAR2 TYK2 IFNAR1 IFNA8 MAVS RIGI IFNA2 ACE2 IKBKE IRF9 IFNA6 IFNA7 TICAM1 IFNB1 JAK1 IFNA1 IFIH1 IRF3 TLR3 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260211%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 NFKB1 MAP1LC3A IFNG IFNB1 MYD88 TNF TRAF6 IRF3 TLR9 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260211%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ITGB1 CD36 LAMB2 CXCL12 FOXC2 FOXC1 TCF2 VEGFA SHH KDR CTNNB1 PAX2 WT1 SIX1 CD2AP FGF8 NPHS1 NPHS2 NOTCH2 HEL-S-28 LMX1B LHX1 ROBO2 CXCR4 FGFR2 HOXD11 HOXA11 SLIT2 TCF21 GLI3 KIRREL1 ETV4 MAFB NCK2 EMX2 NCK1 FOXD1 EYA1 WNT4 GDNF RET INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP4558%HOMO SAPIENS Interferon mediated signaling IFNA13 IFNA14 IFNA16 IFNA17 STAT2 IFNA10 STAT1 IFNA21 IF1AA9 IFNAR2 IFNW1 IFNGR1 PIK3CA IF1IB1 TYK2 IFNAR1 IFNA8 IFNK IFNA2 IFNL2 IFNL3 PIK3R1 IRF9 IFNA6 IFNL4 IL10RB IFNGR2 IFNLR1 IFNA7 IFNE PRKCA IFNB1 IFNG JAK1 IFNA1 IL6 SIGNALING%WIKIPATHWAYS_20260211%WP364%HOMO SAPIENS IL6 signaling GSK3B CREBBP NR2F6 STAT1 STAT3 CRP VAV1 SHC1 TYK2 SOCS3 IL6 NLK MAPK1 MAP2K4 MAPK3 BAD PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2L1 PRDM1 HDAC1 RPS6KB1 MAP3K7 JUNB IRF1 IL6R VIP RAC1 JAK1 GRB2 NCOA1 TIMP1 SOS1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis GCG INS PCSK2 PCSK1 GLP1R NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260211%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells UGT1A4 CYP2A6 CYP2B6 UGT1A9 AOX1 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260211%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SMAD2 NKX2-1 FOXG1 TGIF1 NODAL TGIF2 GLI3 FGF8 SHH HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260211%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PLCB4 ITGB1 EGFR PAK1 FLT1 INSR CDH6 FGFR4 CDH2 NRAS DDB1 FOXM1 CDH16 IGF1R KDR PDGFRA CTNNB1 MYC KRAS MET FLT3 CTNNA1 FGFR2 ITGB3 ITGA2B PRKACG EPHA2 NTRK1 ITGA1 CDH9 KIT PAK6 CDH8 PRKAR1B DCAF1 PRKAR1A PAK4 CDH4 ITGA2 CDH10 CDH11 CCND1 CDH12 CDH15 AJUBA ITGA4 CDH17 VGLL4 CD44 ITGB7 CDH19 NF2 CDH24 NGFR WWTR1 PPP1R14A CUL4A LIN28B YAP1 CTGF PPP1CC HEL-S-80p RBX1 CSF1R NTRK2 ITGAM FGFR1 ITGB5 ITGB4 FLT4 ITGAE AMOT ITGB8 ITGAV ITGAX ITGB6 CDH18 LATS1 TEAD4 ITGA7 LATS2 ITGA6 HRAS TEAD2 TEAD3 FGFR3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G6 ACSL3 FADS1 ELOVL5 PLA2G4B FADS2 ACOX1 ACSL1 ACOX3 ELOVL2 FACL4 PLA2G5 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome TUBA2 STAT3 AMER3 STMN2 MZT2A FAM168B CCDC74A CDC27 CCDC42 ARHGEF4 POTEE GPR148 ARHA RAC1 APC PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260211%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS TLR4 ITGB1 MYH9 LAMB2 HEL113 CDH2 MYO1E SCARB2 SMARCAL1 CD151 PTPRO SYNPO CTNNB1 CLDN1 PAX2 FYN WT1 CD2AP INF2 NPHS1 IRF6 NPHS2 HEL-S-28 LMX1B NOTCH1 CDKN1B HEL114 ITGB3 CD80 WNT1 CR1 PLAUR COL4A3 COL4A5 DAG1 LAMA5 TGFB1 PLCG1 CDKN1C COL4A4 TRPC6 MKI67 CTSL KIRREL3 DKK1 VTN KIRREL2 LRP5 TLN1 PARVA LRP6 FAT1 AGRN LIMS1 PLCE1 ACTN4 PCNA ITGB4 YWHAQ ITGAV NCK1 CDKN1A MME EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260211%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways LIF PDGFRA PTPN11 EGF FGFR2 SELENOP STAT3 ARAF ACVR1 SMAD1 ACTR2 ERAS ACVR2B PIK3R2 SMAD6 FZD1 WNT10B WNT10A FZD3 MDM2 FZD2 FZD5 FZD7 BMPR1A FZD9 FZD8 BMPR2 PTEN JAK1 HRAS FGF23 EGFR SMAD4 FGFR4 PDGFA BRAF BMP4 WNT7B WNT7A DKFZp781O1323 FGF10 CTNNB1 AKT3 MAP2K3 MAPK1 MAPK12 MAP2K6 MAP2K1 MAP2K2 WNT5B IL6ST HNF1A RAF1 DVL1 DVL2 FGF8A DVL3 WNT1 WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD MAP2K5 AXIN1 JUN WNT16 MAPK7 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC FGF14 FZD4 SMAD9 FGF13 FGF18 FGF12 FGFR1 FGF2 WNT9B FGF7B FGF7A NOG FOS MAPK6 MAPK4 FGF5C GRB2 SOS1 FGFR3 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260211%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CYP11A1 MAPK10 STAR HEL-S-2a CASP3 BAX HSD3B2 PARP2 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260211%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin CAMK2A FHL2 GUCY1B1 MAPK1 FHL1 MAP2K1 MAP2K2 ADRB1 MYPN TTN RAF1 CSRP3 NUP62 ANKRD2 HEL-S-101 ANKRD23 C22orf13 MDM2 PRKACG TRIM55 TCAP NBR1 ADRB2 TRIM63 PRKCA PRKAR1A ANKRD1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260211%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 SOX17 FOXC2 FOXC1 TCF2 BMP4 GATA3 CTNNB1 SPRY1 PAX2 WT1 SOX11 LHX1 ROBO2 HOXD11 HOXA11 HOXC11 SLIT2 IFT27 GLI3 SALL1 IFT25 ROBO1 SIX2 GREM1 ALDH1A2 EYA1 GDNF FAT4 RET BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5031%HOMO SAPIENS Biotin metabolism including IMDs ACACA PCCA PCCB ACACB PC MCCC1 BTD HLCS MCCC2 HUNGER AND SATIETY%WIKIPATHWAYS_20260211%WP5445%HOMO SAPIENS Hunger and satiety GCG LEP POMC GHRL MC4R AgRP NPY PYY ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260211%WP4298%HOMO SAPIENS Acute viral myocarditis TLR4 MMP9 STAT1 SGCA SRC SOCS1 DMD MAPK1 TNF FYN MAPK3 HEL-S-28 BCL2L1 BCL2 EIF4G1 CXCR4 CD80 CASP6 RAC3 IL12B IL12A TICAM1 NFKB2 CD40LG IFNG PABPC1 CCND1 CYCS GSK3B DAG1 CASP9 NOD2 CASP3 TGFB1 HLA-DMA STAT3 BAX IL10 CASP2 DFFB DFFA IL2 IL6 TLR5 CCR5 CASP8 CD55 CCR3 PIK3R1 PARP1 AAG1 PS1TP5BP1 PYCARD CAAP1 SGCD EDN1 CXADR SGCB MYH6 SGCG AIF1 CHRAC1 CREB1 BNIP2 ABL2 MICA JAK1 SOS1 TLR3 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260211%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 NLRP3 IKBKE CHUK RELA FCGR2A TBK1 IKBKG NFKB1 IFNB1 IKBKB IL1B REL GSDMD CGAS NLRX1 MITA F3 NFKBIA IRF3 NFKBIE LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260211%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G1B PLA2G4E SLCO2A1 PLA2G4C PLA2G3 PLA2G7 PLA2G10 PTGS2 ALOX5 PLA2G5 PLA2G6 CDKN1A HRAS PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYLK EGFR PAK1 ACTR3 DAAM1 MYL1 PFN4 PFN3 PFN2 CAMK1 SRC SHC1 CTNNB1 NEF3 MYC ERBB2 MAP2K4 MAPK1 NEFH ERBB4 NEFL GPX1 HEL-S-44 MAP2K1 TGFA RAF1 CDKN1B DVL1 PPP2CA PFN1 GSK3B MAPK8 AXIN1 FZD10 PLCG1 ROCK2 WNT16 JUN TMSB4X ARHA ACTR2 APC FZD4 FZD1 FZD3 CBL FZD2 FZD5 FZD7 FZD9 NCK1 FZD8 CDKN1A ACTA1 GRB2 SOS1 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260211%WP5360%HOMO SAPIENS KCNQ2 related epilepsies KCNQ2 CALM1 STX1A PPP1R10 KCNQ3 PLCG2 AKAP5 P2RY1 CSNK2A1 SCN1B CHRM1 PRKCA BDKRB2 PPP3CC AGTR1 BACE1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260211%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling CAMK2A ADCY3 ADCY1 ADCY8 CNTF CAMK2G IL10RA BDNF LIF LTA SOCS3 GFAP GRIA2 GRIN3B GRIN3A GRIA3 GRIA4 IL10RB IFNGR2 IL12B IL12A IL6R IFNG SLC1A4 CAMKK1 CAMKK2 TRAF5 TGFB1 STAT3 IL10 IFNGR1 IL13 PPP1CC ARC IL4 HEL-S-80p SLC2A3 SLC1A1 GRIN2B SLC6A9 GLS2 DLAT JAK1 TGFBR2 IL1A PLCB4 SMAD2 PLCB1 SMAD4 PLCB2 INSR STAT1 IGF1 PSAT1 TGFBR1 PSPH NELF GRIN1 SLC38A3 SLC38A5 DAO GRIK5 SLC1A2 GRIK3 IRS1 GRIK1 SLC7A10 MAPK1 TNF GRM2 GRM4 MAPK3 GRM8 PHGDH SRR LRRC8C IL6ST LRRC8D DISC1 LRRC8E BCL2 HEL-S-51e PRKCB PRKCA NFKB2 IL1R1 SLC38A1 GLS HEL-S-15 PIG59 GRIK2 TGFBR3 TNFRSF1A NFKB1 IL6 DLD CALM1 PDHA1 SLC1A3 SHMT1 FGF2 SLC17A6 SLC17A7 FOS IL13RA1 NGF PLCB3 TNFRSF1B CREB1 IL1B IL1R2 CAMK2D CAMK4 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 ADAMTSL2 EGF ZEB2 LTBP1 ZNF423 pp6425 BAMBI FBN1 LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 GDNF SIGNALING%WIKIPATHWAYS_20260211%WP5143%HOMO SAPIENS GDNF signaling WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260211%WP399%HOMO SAPIENS Wnt signaling and pluripotency CCND2 CREBBP PPP2R3A EP300 PPP2R2C FOXD3 PPP2R2B POU5F1 WNT7B WNT7A CTNNB1 MYC CTBP2 MAP2K4 SOX2 WNT5B ZBTB33 LDLR PPP2R1B PPP2R1A LRRK2 PPP2R2A LEF1 CCND3 FBXW2 PAFAH1B1 PPM1J PRKCH NKD1 NKD2 PRKCB NFYA MAP3K7 ESRRB NR1C2 PRKCE PPP2R3B DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 WNT4 WNT3A PRKCI PRKCQ PPP2CA PRKD1 CCND1 GSK3B WNT2B CD44 MAPK10 PRKCZ MAPK9 AXIN1 FZD10 FRAT1 AXIN2 WNT16 JUN CSNK1E LRP5 NLK LRP6 ARHA APC CTBP1 FZD4 FOSL1 FZD1 WNT10B CTNND1 WNT10A FZD3 FZD2 PPP2R5E WNT9B FZD5 FZD7 FZD9 FZD8 PPP2R5C MMP7 PTPA SLC25A46 PATHWAY%WIKIPATHWAYS_20260211%WP5521%HOMO SAPIENS SLC25A46 pathway EMC7 MICOS13 OPA1 MFN2 APOOL MMGT1 IMMT EMC10 TMEM85 COX4NB MICOS10 APOO CHCHD3 CHCHD6 EMC1 EMC2 EMC3 MFN1 EMC6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260211%WP4595%HOMO SAPIENS Urea cycle and associated pathways SLC25A15 MDH2 ASL GOT2 NAGS SLC25A12 ASS1 GLUD1 ARG1 SLC25A13 LDHB FH OTC GLS2 GPT NOS2 HEL-S-32 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260211%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 NFKB1 IL1B PYCARD ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260211%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis PTGS1 TBXA2R GNA13 ARHGEF1 ARHA 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5407%HOMO SAPIENS 15q11q13 copy number variation STX1A CREBBP NECAB3 APP SPEF1 SMC5 RELA SMC6 LYPD6 ENTREP2 UBN1 MLSN2 ANKRD32 GOLGA8T NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J CXNO CGN CCL5 GOLGA8R GJD3 MTMR10 CANX KLF13 MYZAP OTUD7A TJP3 GOLGA8O CDC42BPB GOLGA8Q TRPM1 FANCD2 STXBP1 GOLGA8H CALM1 FAN1 CHRNA7 ANKRD2 GJA1 HDAC1 CXADR TJP1 SIN3A KAT2B STX1B IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260211%WP2007%HOMO SAPIENS Iron metabolism in placenta TF HAMP IREB2 TFRC HEPHL1 TFR2 SLC40A1 MCOLN1 SLC11A2 HEL60 STEAP3 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260211%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism GCG SLC2A4 NR1C2 FFAR3 PYY FFAR2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260211%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 SGPL1 PEMT CHPT1 CEPT1 PISD BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260211%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders ASL OTC NAGS F7 GLS2 ASS1 GPT ARG1 F10 HEL-S-20 IL4 SIGNALING%WIKIPATHWAYS_20260211%WP395%HOMO SAPIENS IL4 signaling PIK3CD IL2RG RELA EP300 CHUK STAT1 STAT3 GAB2 CEBPA CEBPB PIK3CA SHC1 TYK2 NFKB1 IL4 SOCS3 SOCS1 IRS1 MAPK1 FLNA MAPK3 INPP5D BAD ATF2 PTPN11 MAPK11 MAPK14 NFKBIA PIK3R2 PTPN6 PIK3R1 FES SOCS5 CBL RPS6KB1 FOS IKBKB JAK1 STAT5B JAK3 GRB2 SOS1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 CAP1 ELOVL5 IGF2R LPL CYP1B1 CEBPB PICALM SRSF9 TMED10 TMEM43 PHC2 TGFBR2 SRSF10 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260211%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling GSK3B ITGB1 SMAD2 WASL MAPKAP1 IGF1 IGF1R TNFRSF1A NFKB1 IRS1 RPTOR MTOR DEPTOR ACVR2B MLST8 HEL-S-28 EIF4E TNLG5A RPS6KB1 IGFBP5 PRKAB1 AKT1S1 MAP1LC3A TRIM63 PTEN EIF2B2 FBXO32 PPARGC1A RICTOR GDF8 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260211%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission NGFR STAT3 ROCK1 PLCG1 BDNF PIK3CA SHC1 NTRK2 GABRG2 ARHA PIK3R2 PIK3R1 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 CREM GABRE GABRQ GABRA2 GABRP SLC12A5 PIK3R3 GABRA6 PTEN GABRA5 GABRA4 GABRA3 CREB1 GABRG3 GABRG1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260211%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PLCB4 POMC PLCB1 PLCB2 ARRB2 GPR143 PRKACG VEGFA PRKCB DCT GNA15 PLCB3 CREB1 ADCY9 PMEL ASIP GNAS TYRP1 TYR MC1R FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 APOB NR1C1 ACADM HADHB PPARGC1B STK11 ESRRA ACLY MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260211%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation GSK3B SPRED1 MAP1B MARK1 TAOK1 PHLDB2 MAPRE1 F2RL2 PAK1 STAT3 RHO ROCK1 SRC PARD6A CLASP1 NTRK2 LIMK1 APC CDC42 EPHB2 DVL1 AURKB NTRK1 PRKCA PTEN NTRK3 RAC1 CFL2 WNT3A CDC2 FREP1 TIAM1 MAPKAPK2 TRIO CAMK4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260211%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260211%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol HSD11B1 HSD11B2 RORC EBP AKR1D1 INSIG1 AKR1C4 CYP46A1 THEM5 DHCR7 HSD3B7 GPR183 ACOT8 LBP ACOT7 NR1H2 ACOT11 ACOT12 BAAT ACOT13 CYP7B1 SULT2B1 CH25H AMACR ACOT6 SLC27A2 ACOT4 CYP3A4 DBP CYP7A1 NR3A2 EPHX2 CYP27A1 NR1i2 CYP8B1 SLC27A5 SULT2A1 IL25 ACOT9 IL17F IL17D IL17C IL17B IL17A BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260211%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPHK1 SGPP2 SGPP1 SPTLC1 SPTLC2 KDSR SPHK2 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260211%WP727%HOMO SAPIENS Monoamine transport and regulation STX1A TDO2 TSC2 TPH2 ACHE TGFB1I1 TNF HRH3 NECTIN2 MAPK14 ADORA2A SLC5A7 ITGB3 SLC6A3 TNFRSF11B TH RBL2 UNC13B IL1R1 FBXO32 AMPH IL1B SLC6A1 SLC6A2 SYN1 DBH ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260211%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR SLIT2 RAC1 ROBO4 VEGFA PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260211%WP136%HOMO SAPIENS Phase I biotransformations non P450 CES2 CES1 PON3 PON2 ESD PON1 LIPA HEL126 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260211%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling LOXL1 LOXL2 LOX SMAD2 SMAD4 MAPK9 BMP1 MAPK8 TGFB1 GREM1 TGFBR1 BMPR1A BMPR2 MAPK14 TGFBR2 LOXL4 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260211%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL GOT2 GAD2 AGXT ASPA ASS1 GAD1 GPT PC ABAT MEVALONATE PATHWAY%WIKIPATHWAYS_20260211%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 PMVK MVD ACAT2 HMGCR FDPS SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260211%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis NOTCH1 DLL3 MESP2 LFNG HES7 EPHA4 RIPPLY2 TBX6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260211%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 DHCR7 LBR HMGCR NR1H2 CH25H FDFT1 SQLE SOAT1 FADS2 SCD CYP27A1 FADS1 MYLIP ELOVL5 FASN ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK SREBF2 HMGCS1 SOAT2 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 FACL4 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members PARP14 PARP11 PARP1 HDAC2 RBX1 STAT1 STAT3 HDAC3 DTX3L BTRC SKP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP47%HOMO SAPIENS Hedgehog signaling SMO SUFU DHH PTCH2 SAP18 KIF7 SIN3A PTCH1 IHH GLI3 ADRBK1 SHH ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 IFNAR1 TNF ACE2 IFNA1 TNFRSF1A SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260211%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS5 PLPP1 CERS1 CERS2 CERS3 CERS6 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 SPTLC1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 PLPP3 PLPP2 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260211%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN2A CCND2 SMAD4 BAK1 INSR NRAS MAP3K1 WNT7B WNT7A SHC1 CTNNB1 HMGB1 MYC AKT3 IRS1 ERBB2 MAPK1 SOS2 KRAS WNT5B BCL2L11 BCL2 LDLR CDKN1B BBC3 LEF1 TNFSF6 CCND3 RAC3 MAP3K7 RBL2 DVL1 PIK3R3 DVL2 TCF7L2 DVL3 TCF7L1 NFKB2 PMAIP1 WNT1 WNT3 MLKL WNT4 G6PC1 PCK2 WNT3A CCNG2 CCND1 GSK3B WNT2B PIK3CD MAPK10 MAPK9 MAPK8 TGFB1 TP73 BCL6 BAX AXIN1 FRAT1 WNT16 JUN PIK3CA NFKB1 ARHA BAD BIK PIK3R4 APC PIK3R2 PIK3R1 CDC42 PIK3R5 FOSL1 PIK3C2G FOXO3A WNT10B PIK3C2A WNT10A MDM2 PIK3C2B ATM PPP2R5E CDKN1A PTEN PPP2R5C RAC1 HRAS GRB2 SOS1 BURN WOUND HEALING%WIKIPATHWAYS_20260211%WP5055%HOMO SAPIENS Burn wound healing TLR4 MMP9 FST KLF4 TNC INHBA FGFR4 VEGFA SNAI2 HMGB1 HGF ACHE TNF CCL2 COL1A2 BCL2 EGF CHRNA7 CXCR4 FGFR2 FBN1 F13A1 PECAM1 FOXE1 HEXD DKFZp686P11128 DCN TIMP1 KRT6A KRT222 FLG IL15 PCTK1 SCEL HEL-S-43 COL1A1 AMBP SLURP1 MYD88 CASP3 LIN28A CD3E CXCL12 TPT1 BAX NFKB1 IL6 CXCL8 S100A6 IFNA2 BRD4 FGFR1 S100A9 NOX4 MMP28 ACTA1 IL8RB IFNB1 MMP2 IL1B CXCL1 FGFR3 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260211%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione HEL-S-64p C7orf24 OPLAH GCLC HINT1 PATHWAY%WIKIPATHWAYS_20260211%WP5523%HOMO SAPIENS HINT1 pathway MAPK9 CDK7 RUVBL1 GTF2H2C_2 KARS1 CCNH GTF2H2 JUN GTF2H3 GTF2H5 SH3RF1 FOS NFKB1 HINT1 ERCC2 TCF4 RUVBL2 CTNNB1 MNAT1 NFATC2 USF2 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260211%WP696%HOMO SAPIENS Benzo a pyrene metabolism HEL-S-165mP AKR1C1 EPHX1 AKR1C4 AKR1C2 CYP3A4 CYP1B1 CYP1A1 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260211%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis XPO5 DGCR8 DICER1 DROSHA ERI1 AGO2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260211%WP4537%HOMO SAPIENS Hippo YAP signaling NF2 MAP4K1 MAP4K2 WWTR1 MINK1 YAP1 MAP4K3 RASSF1 LATS1 TEAD4 LATS2 STK38L TNIK TEAD2 TEAD3 HEL-S-31 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260211%WP12%HOMO SAPIENS Osteoclast signaling ATP6V1G1 MAPK8 TNFSF11 ITGB3 TRPV5 TNFRSF11B CTSK TNFRSF11A IFNAR1 IFNB1 SPP1 GPR68 AIMP2 ACP5 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB1 CACNB1 CDH2 SGCA CTNNB1 DMD CACNG1 CTNNA1 SLC8A1 CTNNA3 CTNNA2 ACTG1 tmp_locus_29 CACNA2D1 ITGB3 GJA1 LEF1 CACNA1C ITGA2B CACNA1F LMNA EMD TCF7L2 TCF7L1 ITGA1 CACNB3 CACNA1S ITGA2 ITGA4 DAG1 ITGB7 PKP2 JUP ACTN2 ACTN1 ACTN4 CACNA2D3 CACNA2D2 CACNA2D4 RYR2 CACNB4 ATP2A2 DSG2 DSC2 CACNG6 CACNG7 ITGB5 CACNG8 ITGB4 CACNG2 CACNG3 PS1TP5BP1 CACNG4 CACNG5 ITGB8 ITGAV ITGB6 SGCD SGCB SGCG ITGA7 ITGA6 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260211%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GSK3B PIK3CD TSC2 TSC1 NRAS UBE3A BDNF GRIN1 PIK3CA ARC NTRK2 DLG4 AKT3 PRKAA2 EIF4EBP1 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R2 PRKAG1 PIK3R1 PRKAG2 PRKAG3 PRKAA1 GRIN3B GRIN3A NF1 CACNA1C PRKAB2 SHANK3 RPS6KB1 RHEB PRKAB1 GRIN2B PIK3R3 SYNGAP1 PTEN HRAS HOMER1 CAMK4 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260211%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MEF2C ARAF NRAS BRAF GAB2 CRK MAP3K2 VAV1 SRC PIK3CA SHC1 AKT3 MAPK1 KRAS CRKL MAPK3 SHC4 INPP5D ATF2 SHC2 MAPK11 SHC3 MAPK14 BCR PIK3R1 BCL2 EIF4B HSPB2-C11orf52 BCLAF1 BCL9 RAF1 CBL RPS6KA1 SPAG1 PXN DOK1 HEL-S-102 HRAS GRB2 SOS1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260211%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PPP3R1 ANGPT2 PRKD3 PPP3R2 PRKCZ RCAN1 PRKCH PKN3 PKN2 PRKCB PKN1 NFATC1 PRKCE PRKCA PLCB3 PPP3CA PPP3CC PRKD2 PRKCI PRKCQ PRKD1 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260211%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling IFITM3 CEBPB CCL8 RPTOR CCL4 LARP1 CCL1 DEPTOR MLST8 VPS11 EIF4E VPS16 CCL15 VPS18 GABARAPL2 VPS33A RPS6 RHEB AKT1S1 VPS41 HIF1A AHR LCK IF2B1 TF CD3G IL-21 CD3E CXCL12 IL18RAP PIAS1 IL10 IL13 IL4 IL5 RRAS CXCL8 APOC1 SMAD1 ULK1 SIGMAR1 IL9 HEL117 MMP25 IFIT1 GTSE1 VPS36 WDR74 CD226 TRPM2 APOH APOD RAC1 HEL103 JAK1 INTS4 HRG CXCL13 CTSZ TGFBR2 SERPINA10 SDF2 CCR6 IL1A TOMM70 GP1BA IL16 HMFT1766 IFI6 OS9 PTGS2 MIB1 STAT1 SRP19 HEL-S-81p HP IFI44L CLCC1 TLE3 GTF2F2 UGCGL2 G3BP2 CXCL6 NLRP1 DKFZp781O1323 NPTX1 MDN1 IFITM1 FAM83A CXCL3 NEK9 IL7 CD163 TP53I3 LGALS3BP TNF TRO TRIM59 BST2 ITIH3 ATE1 IFI27 MX1 CCL20 TBKBP1 ATP13A3 IL33 FAM98A CCL22 CCL21 HBB CCL27 PF4 CCL26 DDIT4 RTN4 FGA HEL-S-78p NFKB2 ALB SAA1 SAA2 IRAK1 CASP9 MYD88 CASP3 TRAF2 TRAF6 SRP54 HBD CXCL5 MTOR TPO FGF2 PMPCB IFNB1 ADAM9 IL1R2 CXCL9 PITRM1 CXCL1 CCL3 NLRP3 HEL-S-130P CXCL2 CRP RRM2 GGH CCL11 ZAP70 CARD11 CCL5 EIF4EBP1 HLA-DRA NFATC3 FYN CCL2 APOA2 PTPN6 OAS2 IRF9 C8A IL12A C1QBP CCNB2 IFNG CCNB1 CDC2 IL17A HLA-DRB5 NRF CD8B1 MAPK8 PRG3 CD2 CFH IGLL1 CD8A CFI LBP CFP CTSL CPN1 CASP8 PARP2 C1R SELP HEL-S-72p EGR1 IFIH1 IRF3 CD14 BIRC5 ITIH4 TRAF3 HLA-DRB1 APOL1 ACE2 CASP5 COQ8B ACTG1 TNFSF10 STEAP3 JUNB NTRK1 PRKCQ MOV10 DKFZp762B153 TBK1 IKBKG JUN IL6 CCR5 MAVS RIGI EIF4A2 PS1TP5BP1 CXCL16 FOS IL8RB IL18 IL1B CXCR1 ITCH CAMK4 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260211%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling GSK3B RUNX2 AXIN1 CEBPA CEBPB CSNK1A1 CEBPD CTNNB1 SPP1 APC CSNK1A1L TOR1AIP1 SLC2A4 CDK6 PPARG WNT10B LEF1 ZMPSTE24 FNTA LMNA HES1 EMD HES5 TCF7L2 TCF7L1 ICMT HMGA2 DICER1 TARBP2 CCND1 AGO2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260211%WP5351%HOMO SAPIENS Kleefstra syndrome SMARCD1 SMARCC1 SMARCA4 MBD5 NCOA6 SMARCD2 ARID1A PAXIP1 SMARCC2 SMARCD3 KMT2C ACTL6B DPY30 ARID1B PAGR1 ASXL1 WDR5 BAP1 ACTL6A EHMT1 ASH2L H3F3B RXRA NR1I3 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260211%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways OSTM1 PLEKHM1 NFKB1 SNX10 TNFSF11 IKBKB TCIRG1 TRAF6 RAB7A TNFRSF11A CLCN7 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260211%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 CYP24A1 AGTR2 REN KLKB1 ROCK1 NFKB1 CPN1 KLNA1 BDKRB2 CYP3A4 PRKG1 IL1B MAPK1 NR1i1 TNF ARHA BDKRB1 ACE2 AGTR1 IL1A SERPING1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260211%WP5234%HOMO SAPIENS Bardet Biedl syndrome USP9X PDE6D BBIP1 DYNC2I2 INVS NPHP3 DYNC2H1 CRX DYNLT2B TRAF3IP1 SUFU CEP164 FLCN DYNC2LI1 IFT52 KIF7 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 OCRL CEP290 SCAPER ZIC2 BBS4 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 MAK IFT172 TMEM216 EFHC1 WDPCP EFHC2 IFT74 CNGB1 SDCCAG8 PKD1 CEP104 ARL6 ARL3 PKD1L1 PKHD1 PTCH1 ARL13B TMEM67 INPP5E EVC2 BBS2 NEK8 BBS1 PCARE SMO SCLT1 DCDC2 IFT81 FUZ TTC8 GPR161 MKS1 CEP41 IFT27 TRIM32 GLI3 CLUAP1 RAB23 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260211%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1A2 NAA50 CYP2J2 GATF-C CYP21A2 GLYATL2 AKR1D1 CYP4F11 AKR1C4 CYP46A1 CYP26A1 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 NAA40 NAT10 NAT14 LOC51064 CYP7B1 SULT2B1 HS2ST1 SULT1C3 CYP26B1 CYP4V2 HYAL3 CYP2C19 UGT2A2 CYP3A7 UGT2A1 CYP3A4 GAL3ST2 CYP2W1 GAL3ST3 SULT1C4 CHST8 HS3ST3B1 CHST9 EPHX2 CHST6 CHST7 CYP2R1 CYP3A43 KCNAB1 KCNAB3 CYP2A7 CYP26C1 CHST1 CHST4 CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 CYP17A1 CYP2A13 UGT1A5 AKR1B1 CYP2F1 CYP4B1 HS3ST5 HS3ST6 FMO4 HS3ST4 FMO5 HS3ST1 GSTZ1 CYP20A1 CYP4F2 CYP4F12 HEL-S-165mP EPHX1 CYP7A1 CYP11A1 MGST1 GSTT2 UGT1A3 SULT2A1 CYP1A2 CYP1B1 MGST3 GPX3 MGST2 CYP1A1 CYP2E1 GSTM3 NNMT TPMT INMT GSTM5 CYP4F8 CYP2C8 UGT2B4 UGT2B7 NAT2 CYP2S1 GSTM1 SULT1A1 SULT1E1 BAAT CYP27B1 SULT1C2 CYP11B2 HEL-75 CYP27A1 GSTM2 CYP8B1 GSTA5 CYP2C9 GSTA4 CYP2A6 GSTA3 UGT1A10 CYP2B6 UGT1A1 UGT1A9 HEL-S-64p HS3ST2 GSTM4 GPX4 CYP51A1 CYP24A1 GPX2 HEL-S-22 UGT1A4 UGT1A7 AKR1C1 AKR1C2 HEL-S-75 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 HEL-S-21 HEL-S-166mP UGT2B11 GAL3ST4 UGT2B15 UGT2B17 CYP2U1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST11 CHST12 CHST10 CYP2C18 CHST13 CHST14 NAT8L GSTT2B SULT1A4 CYP4F3 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling CDKN2A EGFR MAPK8 BAK1 BAX TRAF2 TRAF6 JUN TNFRSF1A FAS PDGFRA IL2 IL6 MAP2K3 HBEGF MAP2K4 TNF MAPK12 BMF MAP2K6 MAPK13 MAP3K5 ATF2 FGF7 MAPK11 MAPK14 BCL2L11 BCL2L1 BCL2 NFE2L2 TNFSF10 TNFSF6 CCNE1 JUNB FOS CCNA2 CDKN1A IFNG RB1 MMP2 MCL1 CCND1 TRAF5 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260211%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death BCL2 ATG3 TSC2 INSR TSC1 ATG12 ATG16L1 INS ATG14 MAP1LC3A ATG5 AMBRA1 SH3GLB1 CHAF1A UVRAG ATG9B ATG10 ULK2 VMP1 ULK1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260211%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 APOA4 GCK ACSS1 MTTP LMF1 LDLR PLTP GPIHBP1 LPL FAS PDIA2 APOA5 APOC2 LIPC GCKR DGAT2 APOA2 SEL1L COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome CDCA5 NIPBL SGOL1 PTTG1 ESCO1 ESCO2 REC8 SMC1B MAU2 STAG2 SMC3 STAG3 ESPL1 WAPAL HDAC8 APC PLK1 PDS5B PDS5A PPP2R1B RAD21 PPP2R1A PPP2R5E SMC1A PPP2R5B PPP2R5A AURKB PPP2R5D PPP2R5C PTPA PPP2CA CDC2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5380%HOMO SAPIENS 5q35 copy number variation PDLIM7 SLC34A1 FGFR4 PFN3 IGF1R CAPN3 SRC GRIN1 MYC KDM6B HEL-S-273 COX2 GPRIN1 ARL10 H2AX CXCR4 ADAM10 PTH FGF8A TMED10 HK3 NTN1 COX1 MAPK10 MAPK9 MAPK8 GNAI1 RNP24 PLCG1 PRR7 EIF4E1B GNAI3 JUN COX7B KIAA1191 COX4I1 FAF2 MAX CLTB DDX41 TRIAP1 COX6A1 BABAM1 BABAM2 BARD1 UIMC1 COX8A EED INPP5D TMED9 RNF44 CYP7A1 UNC5A MYO7B PNPLA2 COX6B1 PIK3R1 ARFGAP2 FBXW7 HIC2 DOK3 CDHR2 FAM193B DBN1 ABRAXAS1 USH1C BRCC3 COX7A1 LMAN2 MAGED1 RAB24 COX7C COX3 ZNF346 SNCB PRELID1 PTPRN2 NELFB NOP16 GRIN2B MUPCDH COX5A HIGD2A TSPAN17 BRCA1 DRD2 SNCA ANKS4B H3F3B MXD3 FRS2 ABHD5 GRB2 SOS1 RGS14 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5275%HOMO SAPIENS Ether lipid biosynthesis DHRS7B AGMO AGPS LPIN1 LPIN2 LPIN3 CEPT1 FAR1 UGT8 PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 GNPAT PEX7 PEX5L PEX3 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation MIXL1 ITGB1 KLF4 CNP HOMER3 MBP FOXD3 MSX2 PAX3 MOG S100B OLIG2 SOX10 GFAP ACHE TWIST1 GATA4 NEFL MSX1 LHX1 GAD2 NR2A1 TPM1 GAD1 GATA6 MAP2 TWIST2 DLG4 CLDN11 ERAS CASK CACNG2 ROBO1 SHANK3 GRIN2B SLC6A5 SLC6A9 DLG2 SHANK1 SLC6A1 SLC6A2 HOMER1 TNC AQP4 RIMS2 BSN CDH2 RBFOX3 FBXO15 TBR1 SNAI1 ZFP42 SNAI2 LIN7A BMP4 FUT4 POU5F1 TPH1 ChAT HOMER2 GRIN1 FEV CD24 NEF3 PCLO ERC1 SLC1A2 CD34 PAX6 ADRA2C ADRA2B ADRA2A DPPA3 DPPA2 SOX2 DCX TBXT GLRA1 GLRA2 LMX1B GLRA3 NOTCH1 GABBR1 HTR5A GLRB RIMBP2 NLGN1 5HT1A CSPG4 FOXA2 SLC6A3 LEF1 HES1 ESRRB HES5 PECAM1 GLS NGFR SOX17 PIG59 GPHN GABBR2 KCNJ6 SNAP25 SOX9 SLC1A3 NODAL AP2A1 AP2A2 TH SLC17A6 SLC17A7 FGF7A SLC18A3 HES3 UNC13A ITGA6 SYP CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK10 ADCY1 MAPK9 MAPK8 DAGLA CYP2C19 CYP3A4 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 ADORA2A FAAH CYP2C9 CNR2 NAPEPLD DAGLB PRKACG CYP1A1 PRKAR1B CNR1 PRKAR1A AHR TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3R5 PIK3CD EGFR RAF1 PIK3C2G PIK3C2A PIK3C2B NRAS PIK3CA PIK3R3 AKT3 ERBB2 MAPK1 ERBB4 KRAS MAPK3 HRAS PIK3R4 PIK3R2 PIK3R1 ERBB3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260211%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IF2B1 IL15 RORC RORA ID2 TBX21 IL13 GATA3 TOX IL4 IL6 IL5 IL7 TNF IL33 ZBTB16 HNF1A TSLP IL9 IL25 GFI1 ATL1 NFIL3 IL12B IL12A IL18 IFNG IL23A IL1B AHR IL17A AREG MAPK SIGNALING%WIKIPATHWAYS_20260211%WP382%HOMO SAPIENS MAPK signaling TAOK1 CACNB1 LAMTOR3 RRAS2 CACNG1 SOS2 EGF FGFR2 PRKACG PLA2G4B ARAF CDC25B NFATC1 MAX RASGRP3 RAP1A RRAS DDIT3 CRKL GADD45A CACNA2D3 CACNA2D2 PPP3R1 CACNA2D4 PPP3R2 CACNB4 CACNG6 CACNG7 CACNG8 NF1 CACNG2 CACNG3 CACNG4 CACNG5 MAP3K13 IKBKB PPP3CA RAC1 PPP3CC HRAS TGFBR2 IL1A EGFR NTF4 PAK1 RELA FGFR4 NRAS MAP3K1 MAP3K7IP1 FAS FGF10 RPS6KA3 MAP2K3 MAP2K4 TNF MAPK12 MAP2K6 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K11 SMIM40 RAF1 TNFSF6 CACNA1C CACNA1F FGF8A NFKB2 IL1R1 CACNA1S FGF6B MAPKAPK2 MAP2K5 CASP3 CHUK TRAF2 TRAF6 CRK TNFRSF1A MAPK7 NTRK2 NLK FGF20 FGF22 FGF7 FGF21 FGF8 DUSP4 FGF9 FGF16 FGF14 FLNB CDC42 FGF13 TAOK2 FGF18 FGF12 FGFR1 FGF2 FGF7B FGF7A DUSP2 NGF FGF5C IL1R2 GRB2 SOS1 FGFR3 MEF2C BDNF FLNA NFATC3 STK4 RPS6KA4 RPS6KA5 RAC3 MAP3K8 MAP3K6 MAP3K7 MAP3K12 HEL-S-31 MAPK10 MAP4K1 MAPK9 MAP4K2 MAPK8 TGFB1 MAP4K3 MAP3K2 HEL-S-103 HEL-S-72p RASGRF1 MAPKAPK5 HSPA2 PLA2G4F CD14 FGF23 PLA2G4D PLA2G4E PLA2G4C PDGFA BRAF TGFBR1 MYC AKT3 JUND MAPK1 DUSP10 KRAS MAPK3 ATF2 CACNA2D1 LRRK2 MAPK8IP3 MAPK8IP1 ECSIT DUSP3 DUSP8 DUSP9 DUSP7 PRKCA RAPGEF2 NTRK1 NTF3 TAOK3 CACNB3 RASGRP4 CACNA1H CACNA1G CACNA1I HEL-S-102 RASGRF2 DUSP16 PPM1B RASA2 pk ATF4 PPP5C MAPK8IP2 RELB IKBKG JUN GNG12 MAPKAPK3 NFKB1 MAP3K14 CACNA1B CACNA1A ARRB2 FOS IL1B PTPN5 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP4159%HOMO SAPIENS GABA receptor signaling GPHN GABBR2 GABRG2 SLC6A11 GABBR1 GAD2 AP2A1 GAD1 AP2A2 GABRB3 GABRB2 ABAT AP2S1 GABRB1 GABRE GABRQ GABRA2 GABRP AP2M1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 SLC6A1 GABRG1 SLC32A1 ALDH9A1 EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260211%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria HEL25 CBX3 MBD2 CBX1 CHD4 HDAC2 CHD3 MTA2 H3C8 RBBP7 MTA3 MBD3 HDAC1 LEF1 SUV39H1 KDM1A H3C15 RB1 H3F3B RBBP4 KALLMANN SYNDROME%WIKIPATHWAYS_20260211%WP5074%HOMO SAPIENS Kallmann syndrome TMEM98 GNRH1 NEUROG1 FGFR1 SEMA3E ASCL1 OTX2 ANOS1 PIK3CA PLXND1 OLIG2 PROK2 SOX10 MYRF FRS2 MAPK1 LHB PTPN11 FGF8 GRB2 MAP2K2 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260211%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma DKFZp762B153 NFE2L2 STAT3 TFEB MDM2 IPO8 PINK1 AGER PARK2 NFKB1 HMGB1 SQSTM1 KRAS VMP1 SHOC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260211%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence CYP2C8 FADS1 ELOVL5 ALOX12 LTC4S PTGS2 CYP2C9 HEL-S-22 ALOX5 ALOX15B CYP1A2 ALOX15 HPGD GPR32 FPR2 CYP2E1 PTGS1 PTGIS CYP3A4 GSTM4 FADS2 EPHX2 ELOVL2 PTGES SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260211%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 RPS6KA5 BRAF HTR4 HTR6 HTR7 RAP1A CREB1 MAPK1 EGR1 MAPK3 ATF1 GNAS MAP2K1 MAP2K2 MAPKAPK2 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260211%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors MVD HMGCR 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome AFDN F11R GJA3 GJA5 ACP6 CTNNB1 GJA8 AMELX NBPF12 CHD1L PRKAA2 PYGO2 TJP3 PRKAG1 PRKAG2 PYGO1 BCL9 PRKAG3 PRKAA1 GJA1 KIRREL1 PRKAB2 PRKAB1 FMO5 TJP1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260211%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex HIST1H2BE HAT1 ASF1A CREBBP ASF1B HDAC2 EP300 MBD3 EP400 MAPK3 H2BC21 H2AX HDAC1 TLK2 RBBP4 KAT2B MBD2 CHD4 CHD3 MTA2 H3C8 H3C15 PWWP2B UBTF PWWP2A TBP SIRT7 POLR1A POLR1C POLR1D RRN3 SRCAP TAF1D H2AC19 TAF1B H2AB1 TAF12 H2AC14 GATAD2B H2BC26 GATAD2A H2BC12L CDK2AP1 HIST1H2AB H2BC9 KAT2A H2AZ1 H2AZ2 H2BC8 H4C9 H2AC6 HIST1H4L H2BC3 H2BC1 H2BC17 H3F3B H2BC12 H2BC13 H2AJ H2BC14 H2BC15 H2AC20 H2BC11 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260211%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PLA2G1B PTDSS2 PTDSS1 CHKB PCYT2 ETNK1 GPAM PEMT CDS1 CHPT1 CRLS1 PISD AGPAT4 GPAT4 PNPLA3 DGKZ DGAT1 DGAT2 CDIPT PNPLA2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260211%WP699%HOMO SAPIENS Aflatoxin B1 metabolism HEL-S-166mP EPHX1 CYP3A4 CYP1A2 GSTM1 CYP2A13 CELL CYCLE%WIKIPATHWAYS_20260211%WP179%HOMO SAPIENS Cell cycle MCM5 MCM6 TTK CDKN2A CCND2 FZR1 HDAC2 CDC45 WEE2 EP300 CDKN1B CCND3 E2F2 ANAPC1 SMC1A CCNA2 CCNE2 CCNB3 CCNB2 RB1 CCNB1 GADD45B CDC2 GADD45G CCND1 CHEK2 CHEK1 PTTG1 TGFB1 SMC1B CDC25B STAG2 CCNH SMC3 CDC27 ESPL1 E2F4 GADD45A PLK1 TFDP2 MCM2 RAD21 CDK7 MAD2L2 STAG1 MDM2 CCNE1 ATM ATR CDC20 SMAD2 SMAD4 WEE1 CDK4 MYC CDK2 HEL2 HDAC1 RBL2 RBL1 TFDP1 CDKN2D CDKN2B E2F5 CDKN2C GSK3B SFN CDKN1C SKP1 RBX1 PRKDC PCNA CDK6 E2F3 YWHAQ HEL-S-1 CDC14B YWHAG CDC23 PTTG2 SKP2 ANAPC7 ANAPC5 YWHAZ MAD1L1 ANAPC2 CDKN1A ANAPC13 PKMYT1 ANAPC11 ORC6 ORC3 ORC2 CDC6 MCM7 ORC1L DBF4 MCM3 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260211%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23 HEL-S-310 RPS6KA2 RPL4 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL8 RPL9 RPL6 RPS4X RPS15 FAU RPS14 RPL13A RPL7A RPS6KA3 RPS17 RPS16 RPS18 RPL36 RPL35 RPL38 RPL37 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPS6KB2 RPL5 RPL22 RPS3A RPL30 RPL7 RPSA RPS6KA6 RPL18A RPS6 RPL37A RPL29 RPL28 RPL10 RPL12 RPS11 MRPL19 RPS6KB1 RPL36A RPS4Y1 RPS15A RPL14 RPS19 RPS3 RPS27A RPL13 RPS2 RPL11 RPL15 RPL18 RPL17 RPL19 RPL27 RPL41 RPL35A RPL26 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPLP2 RPL10A RPS6KA1 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2858%HOMO SAPIENS Ectoderm differentiation HDAC10 FHL2 LDB2 PAX3 SOCS2 DMD HDAC6 FYN CCL2 CDON PRKAG2 ZBTB16 LHX1 CTNNA2 FGFR2 MAFB POU2F2 ELOVL4 GATA6 NR1C2 TCF3 NUMA1 CDH8 SDCBP GAS2L1 KRT6A RGMA NF2 CTNND2 ARHGDIG KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E ARX STC1 NFATC1 ARHGAP15 ZBTB2 JUP PLXNA2 RHPN1 ST8SIA4 HESX1 ZBTB7B TFAP2C SMURF1 GREB1 NR2F2 CLDN11 PAN2 PTPRB PPFIBP2 SCHIP1 HMGB2 WDR44 SIX6 AHI-1 BOC RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 FZD5 ARHGEF9 BMPR1A KIFC3 RUTBC3 STX16 FZD8 RRBP1 TBL1X CLVS1 TTC14 TNLG7C SNCA C1GALT1 TRPM2 VAX2 RIT1 GLB1 ZNF219 BCOR SKIL MYORG ELOVL2 SMAD4 CDH6 OGT BMP4 SHH CTNNB1 MYC PAX6 TFAP2A SOX2 CAP2 PDE7A NLGN1 FOXA2 TNFRSF11B TCF7L1 WNT1 SPRY2 CELSR2 NLK UBTF ZFHX4 PTPN13 PIM1 CTBP1 FZD4 MKS1 GLI3 H2BC9 TOX3 CAMKK2 PATHWAY%WIKIPATHWAYS_20260211%WP4874%HOMO SAPIENS CAMKK2 pathway GALNT9 MAMDC2 ATP1B2 MID1 ERAF CRTC2 SPINT1 PAK1 C1QTNF12 EPOR EP300 FAM20C RELA SPIRE1 ARHGEF7 SFI1 IFI44L ATP10D TSPAN33 RHD CAMK1 ENHO CYB5R3 TSPAN8 SLC25A21 NLRP1 KDR FIS1 STIM1 SLC38A5 WFS1 KLF1 LR8 SLCO3A1 CCL5 TRPV4 CPOX MAPK1 RHAG TNF MAPK3 NFATC2 HFE RPTOR TBXT SLC2A4 ACACA RAF1 FASN NFE2L2 RPS6 SIRT1 ABCA1 RPS6KB1 SMC1A MAP1LC3A SQSTM1 HIF1A CAMKK2 PCK2 CCND1 MX2 KEAP1 VCAM1 GCK IL15 HMBS DKFZp762B153 CHRM3 TSC1 WDR35 DGIC HMOX1 PFKFB2 HK2 ULK1 MTOR CALM1 SELL PARP1 ASNS CCNE1 S100A8 AQP1 CREB1 RAC1 MAF MS4A3 CXCL11 IFGGE OASL ERMAP CAMK4 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260211%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CHRNB4 CACNA1C RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260211%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis PIK3CA EGFR PTEN RPL11 AKT3 FOXO3A MAPKAP1 RICTOR RIOK2 RIOK1 MTOR MLST8 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260211%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 MAVS RIGI IFIH1 MR1 IRF3 TLR8 TLR7 TNFRSF11A TLR3 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260211%WP3958%HOMO SAPIENS GPR40 role in insulin secretion GNA11 PLCH1 PLCD3 PLCB1 PLCB2 PLCB3 PKD1 PLCG2 PLCG1 PLCL1 PLCE1 FFAR1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260211%WP3407%HOMO SAPIENS FTO obesity variant mechanism IRX3 ARID5B TBX1 UCP1 PRDM16 PPARGC1A IRX5 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260211%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260211%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC RBX1 CBFB CUL5 UBB RUNX1 APOBEC3G NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism B3GNT5 NEU2 FUT5 B4GALT1 FUCA1 FUT1 NAGA FUT2 SIAT4C B4GALT4 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260211%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NFE2L2 TGFB1 NQO1 SIRT1 CDC37 EXOC6 ECSIT DDR1 SUV39H1 NRF1 HEL-S-7 PKD1 COL2A1 FGF7 BMP2 IGFBP7 LOXL4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome SMC1A RAD21 RAD18 PAXIP1 BRCA1 MRE11A MDC1 ATM SMC3 NBN RAD50 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260211%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells SELE TLR4 SELP TGFB1 SELPLG PF4 CD40 CD40LG CCL5 IL1B CCL2 TLR7 VCAM1 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5304%HOMO SAPIENS Cholesterol metabolism CD36 STAR PBR LIPC LIPA APOA2 CYP27A1 PCSK9 APOA4 SCARB1 MTTP APOB LDLR MYLIP PLTP ACAT2 LPL HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK LIPG MVD NPC1 ANGPTL8 ANGPTL3 SLC27A4 LRPAP1 SAR1B MGAT1 CIDEB FABP2 VAPA EBP CYP51A1 SC5D DHCR24 DHCR7 LBR LPA HMGCR FDFT1 DGAT1 SORT1 SQLE APOC2 SOAT1 APOC3 ABCG8 APOC1 ABCG5 CYP7A1 APOE ABCB11 APOH STARD3 NPC1L1 NPC2 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260211%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 DROSHA MRE11A ATM NBN RAD50 DDX1 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260211%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 NFE2L2 SLC3A2 SLC7A5 KEAP1 ATF4 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260211%WP4249%HOMO SAPIENS Hedgehog signaling HHIP SPOP CSNK1G3 CCND2 SMURF2 FBXL17 SPOPL CSNK1D GAS1 CSNK1G2 CSNK1G1 EVC ADRBK1 CSNK1A1 SHH CSNK1E DHH IHH SMURF1 PTCH1 CDON EVC2 CSNK1A1L BCL2 SMO BOC ARRB2 GPR161 GLI3 PRKACG SUFU PTCH2 KIF3A KIF7 CCND1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260211%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ELOVL5 ACE2 FADS2 ELOVL2 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS SLC7A11 PHGDH PSAT1 PSPH ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260211%WP2374%HOMO SAPIENS Oncostatin M signaling RELA STAT1 CEBPB VEGFA SRC TYK2 SHC1 SOCS3 IRS1 CDK2 MAPK1 JUND KRAS MAPK3 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 IL6ST RAF1 CDKN1B RPS6 PRKCH PRKCB PXN JUNB PRKCE PRKCA OSMR HIF1A STAT5B PTK2B JAK3 OSM MAPK9 MAPK8 CASP3 STAT3 NFKB1 MTOR PIK3R1 FOS CREB1 JAK1 RICTOR EGR1 HRAS GRB2 SOS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260211%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness CREB1 MAPK1 RYR3 ITGB3 MFAP5 MAPK3 TNNC1 PRKCQ PLCG1 JUN ITGAV GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260211%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis NOTCH1 MESP2 LFNG HES7 EPHA4 RIPPLY2 WNT3A FGF8 TBX6 HES1 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260211%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption DYNC1H1 DCTN1 ADCY3 RAB11B DYNC1LI2 DNCL1 ADCY6 AQP4 ARHGDIG DCTN6 DCTN5 DYNC1I1 RAB5B DCTN4 HEL-S-47e HEL-S-77 AQP2 AQP3 ARHGDIB AVPR2 DYNC1LI1 RAB11A GNAS RAB5A DYNC2H1 CREB3L3 AVP CREB3L4 PRKACG DYNLL2 CREB3L2 CREB3 RAB5C DYNC2LI1 CREB1 ADCY9 STX4A CREB5 VAMP2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260211%WP712%HOMO SAPIENS Estrogen signaling BCL2 MAPK9 CHUK GNGT1 BRAF IKBKG JUN PIK3CA FOS NFKB1 SP1 GPER IKBKB CREB1 MAPK1 GNB1 GNAS MAP2K1 MAPK14 CORI CYCLE%WIKIPATHWAYS_20260211%WP1946%HOMO SAPIENS Cori cycle INS SLC2A4 HEL-S-68p PGAM1 HEL-S-133P PFKP GPT HEL-S-49 HEL-S-87p HEL-S-162eP SLC2A2 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP4478%HOMO SAPIENS LTF danger signal response pathway IRAK1 TLR4 IRAK4 MYD88 TRAF6 AGER NFKB1 TREM1 IL6 IFNB1 CXCL8 IL1B MAPK1 TNF HEL110 IFNA1 CD14 IL1A TGFB SMAD SIGNALING%WIKIPATHWAYS_20260211%WP5382%HOMO SAPIENS TGFB Smad signaling SMAD2 SMAD4 WWTR1 SPARC TGFBR3 POSTN CTGF TGFBR2 TGFBR1 YWHAG RAS SIGNALING%WIKIPATHWAYS_20260211%WP4223%HOMO SAPIENS Ras signaling AFDN GNG3 GNG2 GNG5 GNG4 GAB2 GNG7 GNG8 ZAP70 KDR SHC1 KSR1 PDGFRA RRAS2 PLA2G2A SOS2 MET SHC4 LAT SHC2 PTPN11 SHC3 STK4 FLT3 FGFR2 PRKACG RAC3 PLA2G5 PLA2G6 PIK3R3 RAB5C PLA2G4B PAK6 PAK4 MAPK10 MAPK9 MAPK8 CALML6 CALML3 ARF6 CALML4 EXOC2 HTR7 RASGRP3 RAP1A RRAS PIK3R2 PIK3R1 RASGRF1 NF1 GRIN2B SYNGAP1 IKBKB ABL2 RAC1 HRAS KSR2 PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D RALA PLA2G1B PLA2G4E PLA2G4C PLA2G3 EGFR PLA2G10 PAK1 FLT1 INSR RELA FGFR4 NRAS IGF1R GRIN1 RASSF1 AKT3 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAB5A BCL2L1 ETS2 RAF1 TNFSF6 EPHA2 PRKCB GNG10 GNGT2 PRKCA NTRK1 RASGRP4 KIT REL RASGRF2 TIAM1 RASA2 PIK3CD NGFR CHUK PLCG2 PLCG1 IKBKG RAB5B GNG12 GNG11 PIK3CA NFKB1 GNG13 CSF1R NTRK2 GNB2 ARHA GNB1 BAD PLA1A GNB4 RASAL1 GNB3 RASAL3 PLCE1 TTBK1 GNB5 RASA4B RALBP1 CALM1 PLAAT3 CDC42 RASA3 RASA4 RIN1 RAPGEF5 PLA2G2F PLA2G2E FGFR1 PLA2G2C FOXO4 PLD2 GNGT1 FLT4 RALB GRB2 SHOC2 SOS1 FGFR3 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CHST7 EXT1 CHST1 CHPF CHST3 XYLT2 XYLT1 EXTL2 HS6ST1 EXTL1 HS6ST2 CHSY1 HS6ST3 CHSY3 CSGALNACT1 NDST3 CHPF2 B3GAT3 GLCE B3GAT2 B3GAT1 CSGALNACT2 B3GALT6 HS3ST1 HS3ST3A1 EXT2 UST CHST11 CHST12 HS3ST2 CHST13 CHST14 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260211%WP1971%HOMO SAPIENS Integrated cancer pathway CHEK1 SMAD2 CASP9 CASP3 STAT1 BAX MRE11A CDC25B MSH6 RAD50 MSH2 BLM CDK4 MYC CDK2 CASP8 BARD1 ATF1 MAP3K5 BAD PLK1 BCL2 CDKN1B BBC3 NOXA1 MDM2 ATM ATR POU2F1 BACH1 CDKN1A PTEN BRCA1 RB1 JAK1 CDKN2B CDC2 CHEK2 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260211%WP2005%HOMO SAPIENS miR targeted genes in muscle cell SPRYD4 AP3D1 PHLDB2 TTC9C ARHG ARCN1 WDR11 SPCS3 EZH2 TPPP3 NFIA NEDD4 CEBPB SNX15 PKN2 LAMTOR3 LAMTOR5 TUSC2 LTN1 CPOX ARID4B CALCOCO2 HEL-S-30 MET HEL-S-273 FADS2 ABHD10 ERBB3 POGLUT3 VPS39 KPNA3 EIF4E AXL MYLIP TPM3 TPM1 GRIA2 STX7 UBE4A ATG9A CDKAL1 RAB30 GPD2 RAB34 NCL PTMAP7 RHEB GEMIN7 ANAPC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 RB1 SLC1A4 CORO1C SDCBP MCL1 CCND1 CD164 BRPF3 HMGA1 SLC4A10 NF2 TBCA IGF2R CSNK1D GNL3L CXCL12 CHMP2A SRPRB DKFZp761E1322 PICALM SLC25A1 DOCK5 TNFAIP2 ADAR LMNB2 CYR61 SYNE2 SYNE1 TMEM109 ACP2 HEL-S-108 SNAP29 PLK1 SCYL1 HSDL1 DSG2 ARID1A TXN2 RCN2 RFT1 RBMS1 SLC25A13 SEC23A LUZP1 NUFIP2 NXN UHRF1 HSD17B12 GNA13 DNAJB1 CAND1 PPP3CA POLR2C TP53INP1 POLD2 IGF2BP1 TGFBR2 SH3BP4 ZNF622 BACE1 CDIPT PDLIM7 SLC25A24 EGFR SLC12A2 GALNT7 NHERF2 GALNT1 TM6SF1 TDG POLE4 SLC4A7 MYO1E FMNL2 PSAT1 RQCD1 SLC25A32 CUL4B BET1 CTNNB1 CSF1 IRS1 MAPK12 MAPK14 PPIF MTRR LPL RTN4 KIT PRKCI COL3A1 DOCK7 RARS1 HEL-S-47e MAPK7 CDK6 E2F3 ITGB4 LAMC2 FGF2 P4HA2 NELFCD CDKN1A TMEM87A VSNL1 FSTL1 CA12 CAMTA1 ACVR1B PPIB HYAL3 ERBB2 CDKN1B LAMC1 C1QBP TNFRSF10B ITGA2 CCNG1 SNAP23 PTPRF COL1A1 SPARC SYPL1 THBS1 GPAM CYP1B1 UBE2J1 SPTLC1 ATP6V1C1 GFPT1 ERG ATP6V0E1 CPNE8 VEZT TMEM41B EHMT1 SLC38A5 CLDN1 PWP1 ABCG2 KRAS CHORDC1 RAVER2 COL1A2 CIAO2A SEC62 NOTCH2 CDK5RAP3 NOTCH1 BCL2 MBNL1 HEL-S-303 CACNA2D1 IFRD1 FNDC3B GJA1 FNDC3A PISD CARHSP1 MTHFD2 TYMS WDR82 FAR1 HES1 HACD3 MRPL20 SLC7A11 BACH1 COMMD9 RDH10 GRPEL2 SNX6 SLC38A1 GSTM4 RAB27B MOV10 POLA2 NCEH1 CYP51A1 PDE3A SFXN1 STRN ANP32B RNP24 NRP1 ARF4 TRAM1 HMOX1 GFM1 ASH2L MAGT1 MRC2 PANX1 COIL SERP1 TMEM43 TMED3 DHX15 GNPNAT1 SH3BGRL3 TMED7 CTSC MRPS24 ATP2A2 ELMOD2 TMT1A AP3B1 SLC7A6 YWHAQ CDCP1 CSDE1 FRG1 PXDN SSNA1 AMIGO2 NAPG HEL-S-66 PTPA NT5E PGRMC1 PPP1R7 USP1 SHOC2 SRSF10 MPZL1 CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260211%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide FAS IL12A VIP IL2 IL4 IL5 IFNG TGFB1 CD80 IL10 CTLA4 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260211%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP4970%HOMO SAPIENS Galanin receptor pathway SLC2A4 POMC CDKN1B PPARG YAP1 CRP VEGFA CDKN1C INS FOS CDKN1A IL6 CREB1 BCL2L11 VAMP2 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260211%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells SMAD2 EGFR RAF1 SMAD4 TGFB1 TGFBR3 AXIN1 NRAS TGFBR1 TSPAN8 CTNNB1 HGF MFGE8 DKK4 ERBB2 KRAS MET WNT3A HRAS MTOR TGFBR2 TGFA APC CD133 FOCAL ADHESION%WIKIPATHWAYS_20260211%WP306%HOMO SAPIENS Focal adhesion MYL11 MYL5 MYLK MYL7 ITGB1 LAMB3 CCND2 TLN2 TXK LAMB2 MYL12A MYL12B MYL10 VASP SRMS CAV3 TNK1 PARVB VAV1 PARVG VAV2 ARHGAP5 DOCK1 SRC STYK1 KDR SHC1 c-fgr PDGFRA ZYX PDPK1 HGF ERBB2 FLNA MET FYN SHC4 SHC2 SHC3 PDGFC HEL-S-28 EGF ITGB3 ITGA2B CCND3 RAC3 LAMC1 PXN IBSP PIK3R3 ITGA1 PAK6 PAK4 PIP5K1C ITGA2 COMP BLK CCND1 ITGA4 MAPK10 COL1A1 ITGB7 LAMA5 MAPK9 MAPK8 PPP1CC THBS1 PPP1R12B HEL-S-80p VTN RAP1A PPP1R12C TLN1 PARVA CRKL SPP1 ACTN1 ACTN4 PIK3R2 PIK3R1 LAMB1 RAPGEF1 RASGRF1 PTEN RAC1 HRAS EGFR PAK1 TNC FLT1 PDGFA BRAF IGF1 VEGFA IGF1R CTNNB1 EMP2 AKT3 MAPK1 MAPK3 COL1A2 MYLK2 MAP2K1 PDGFD BCL2 RAF1 ACTG1 HEL114 PRKCB PRKCA COL2A1 ARHGAP35 MYL2 RELN VEGFB VEGFC GSK3B VEGFD XB PIK3CD TNR CRK COL4A2 BIRC2 ROCK1 COL4A1 BIRC3 ROCK2 JUN COL4A4 COL4A6 PIK3CA CAV2 CHAD ARHA BAD CDC42 FLNB COL5A3 COL5A2 ITGB5 ITGB4 TNK2 LAMC2 PS1TP5BP1 PTK6 ITGB8 ITGAV ITGB6 VAV3 VWF ITGA7 ITGA6 LAMA1 LAMA4 LAMA3 GRB2 THBS2 THBS4 MYLK3 SOS1 THBS3 MYLK4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260211%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260211%WP661%HOMO SAPIENS Glucose homeostasis INS 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5408%HOMO SAPIENS 15q25 copy number variation AP3D1 TM6SF1 HTT SPCS3 HOMER2 AGAP2 RAMAC ZNF592 PDE8A RNMT WDR73 BNC1 BTBD1 GOLGA6L4 ADAMTSL3 SH3GL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB DNM3 RYR1 NMBR RYR2 EGF AP3B2 SPCS2 RAF1 SPCS1 ALPK3 ZSCAN2 SYNJ1 SHANK3 SHANK1 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260211%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism HSD11B1 CYP11A1 HSD11B2 SRD5A2 POR CYP21A2 STAR H6PD HSD3B1 HSD17B3 CYP17A1 CYP11B2 HSD3B2 BASE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4752%HOMO SAPIENS Base excision repair TDG POLE4 SMUG1 HMGB1 PARP2 PCNA PARP1 FEN1 MPG PNKP OGG1 UNG POLD3 POLD4 NTHL1 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 POLD2 NEIL2 APEX1 POLE3 IL19 SIGNALING%WIKIPATHWAYS_20260211%WP5422%HOMO SAPIENS IL19 signaling ACTA2 COL1A1 CXCR4 MAPK8 TGFB1 STAT1 STAT3 SOCS5 CCL11 TNFRSF1A NFKB1 IL4 SOCS1 IL19 CCNB1 MAPK1 TNF RAC1 MAPK3 JAK1 IL20RA MAPK14 IL20RB MUC5AC G13 SIGNALING%WIKIPATHWAYS_20260211%WP524%HOMO SAPIENS G13 signaling RHPN2 HEL-S-15 MYBPH PIK3CD CIT MAPK10 ARHGDIG WASL PIP4K2A MYL1 ROCK1 WAS ROCK2 SH3RF1 PIK3CA ARHGDIB HEL-S-80p LIMK1 ARHA PIK3R2 CDC42 CALM1 IQGAP1 TNK2 CYFIP1 RPS6KB1 PKN1 GNA13 ARHGEF1 RAC1 CFL2 PFN1 RTKN 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5400%HOMO SAPIENS 6q16 copy number variation LEP POMC GHSR GHRL MC4R SIM1 INSR LEPR BDNF INS NTRK2 AgRP NPY CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260211%WP5193%HOMO SAPIENS Cholesterol synthesis disorders EBP CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR IDI1 FDPS MVK HMGCS1 MSMO1 FDFT1 PMVK MVD SQLE HSD3B2 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260211%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT2 GALNT16 GALNT1 B3GALT2 B3GALT1 B4GALNT1 B4GALT1 CERS3 CERK SGMS1 SPHK2 SPHK1 SGMS2 SGPP2 SGPP1 UGT8 UGCG SGPL1 KDSR T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VEGFD IDO1 TGFB1 CXCL12 PDGFA ARG1 VTCN1 VSIR TIGIT VEGFA B2M IL10 SHH TNFRSF4 HAVCR2 IL13 ENTPD1 TNFRSF9 FAS HLA-A PDCD1LG2 IL4 IL6 FAP NR1i1 PDGFD CTLA4 CCL17 PDCD1 PDGFC ICOS CCL22 TNLG5A CXCR4 LGALS9 CD40 TNFSF6 CD80 CD40LG TNLG2B CD226 NT5E VEGFB VEGFC NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260211%WP438%HOMO SAPIENS Non homologous end joining PRKDC POLL WRN POLM NHEJ1 XRCC5 FRAGILE X SYNDROME%WIKIPATHWAYS_20260211%WP4549%HOMO SAPIENS Fragile X syndrome MMP9 CAMK2A CDKN2A BDNF SRC SHC1 AGAP2 HCN1 FYN RPTOR PTPN11 DEPTOR MLST8 EIF4E GRIA2 GAD1 EPHA4 RPS6KB1 RHEB AKT1S1 DAG1 TSC2 APP TSC1 ARAF ARC CLTB DLG4 CYFIP2 GRIP1 CPT1A SH3GL1 GRIP2 ARHGAP32 ABCD3 KCNC1 DLGAP3 TTI1 ALDH5A1 TBC1D7 PICK1 EPS8L1 NF1 CYFIP1 FMR1 GRIN2B SYNGAP1 PTEN PPP3CA SHANK1 SLC6A1 ALDH3A2 HOMER1 MAP1B PLCB1 BRAF CAMK1 AKAP5 GRIN1 MAPK1 KRAS KCND2 MAP2K1 MAP2K2 RAF1 EIF4G1 ABAT EIF4EBP2 DUSP3 PRKCA DICER1 EEF1A1 PRKAR1A TARBP2 AGO2 DKFZp762B153 GPHN RAP1GAP PLCG1 NTRK2 GABRG2 SH3GL3 MTOR EIF4A1 CLTC CLTA AP2A1 GABRB2 AP2S1 CLTCL1 PPP2R5B AP2M1 CREB1 CNR1 GRB2 SOS1 PTPN5 CAMK4 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260211%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism EBP CD36 CYP51A1 SC5D DHCR24 DHCR7 LBR HMGCR FDFT1 DGAT1 SQLE ABCG8 ABCG5 APOA4 MTTP APOB LDLR ACAT2 HSD17B7 TM7SF2 ABCA1 IDI1 FDPS MVK HMGCS1 MSMO1 PMVK MVD SLC27A4 SAR1B MGAT1 NPC1L1 FABP2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260211%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 PTGS1 NR1C1 MVD PTGS2 WNT1 VEGFA 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260211%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260211%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis CAMK2A CREBBP HDAC10 SRC STIM1 NRG1 GRM6 GRIA2 GRIN3B GRIN3A GAD1 GRIA3 GRIA4 SDCBP STAT3 CRTC1 HEL-S-162eP ARC PDIA2 DLG4 GRIP1 SLC6A13 DLGAP3 SLC6A11 PICK1 FRMPD3 ADARB1 CACNG8 SLC6A12 CACNG2 EFNB2 NETO2 CPEB3 CABIN1 ARHGEF9 GABRR3 SLC1A1 GRM3 GABRR1 NPTN NRXN3 GRIN2B ADIJ ADII NWD1 SLC6A8 SNX27 GLS2 ATAD1 SYVN1 LHFPL4 SLC6A1 SNX14 HOMER1 PLCB1 STAT1 CDH2 GRIN1 GRIK5 SLC1A2 GRIK3 GRIK1 MAPK1 GRM2 ERBB4 GRM4 MAPK3 GRM8 MAP2K1 FFAR1 ORAI1 MBD5 SUMO1 HDAC1 ABAT GNA11 SLC7A11 PRKCA PPP2CA DKFZp762B153 PIG59 GRIK2 GABRG2 SH3GL2 SLC1A3 AP2A1 AP2A2 GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG1 SLC32A1 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260211%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 CS ALDH3A2 ACSS2 ACO2 ALDH9A1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer TIGIT PRF1 FOXO1 GATA2 MYC CCL5 TNF CCL2 CCL4 CCL1 ADAM17 ADAM10 FCGR3A IFNG CD226 CSF2 MICA BMI1 KLRK1 NCR3LG1 MICB CD96 NCR1 CCL3 NCR3 COPPER METABOLISM%WIKIPATHWAYS_20260211%WP5189%HOMO SAPIENS Copper metabolism ATP7B SLC31A1 ATP7A SLC11A2 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK10 MAP3K21 MAPK9 MAPK8 ARAF BRAF MAP3K1 PARP14 MAP2K3 MAPK1 MAP2K4 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 PARP1 RAF1 MAP3K8 MAP3K7 MAP3K12 TNKS ATF4 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260211%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment CSF2RA LAG3 TGFB1 CXCL12 CCR2 VEGFA NRP1 HLA-DRB1 KDR FAS CSF1R IFITM2 CSF1 CCL5 CCR5 BAG3 HLA-DRA CCL2 CTLA4 CXCR4 TNFSF6 CD80 ITGB6 CSF2 CXCR3 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome DCTN1 PLAGL1 PCM1 ACTR1B KIAA0753 CEP170 BMERB1 DCTN6 OFD1 NDE1 ABCC6 DCTN4 MARF1 CEP20 DCP1A GATA3 ACTR10 DCP2 RAPGEF4 RAP1A DISC1 PLK1 ABCC1 PAFAH1B1 PLAG1 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260211%WP1584%HOMO SAPIENS Type II diabetes mellitus SLC2A4 PIK3R5 CACNA1A PRKCZ MAPK8 INSR PDX1 SLC2A2 SURF1 PHKA2 IRS1 IKBKB SOCS4 MAPK1 TNF INS-IGF2 MAFA MTOR FOXP3 IN COVID 19%WIKIPATHWAYS_20260211%WP5063%HOMO SAPIENS FOXP3 in COVID 19 FOXP3 IL6R IL2 IL7R IL6 IL2RG STAT3 STAT5B CD80 IL2RA IL6ST IL2RB CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260211%WP4562%HOMO SAPIENS Canonical NF kB pathway NFKB1 IKBKB CHUK RELA REL NFKBIA IKBKG NFKBIE ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260211%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260211%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA4 LMF1 LDLR PLTP GPIHBP1 LPL ANGPTL4 APOA5 ANGPTL8 APOC2 ANGPTL3 LIPC APOA2 SEL1L RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260211%WP2290%HOMO SAPIENS RalA downstream regulated genes CDC42 RALBP1 EXOC2 EXOC8 YBX3 KRAS RAC1 NRAS RAC3 HRAS RALA WNT SIGNALING NETPATH%WIKIPATHWAYS_20260211%WP363%HOMO SAPIENS Wnt signaling NetPath GSK3B MAPK9 MAPK8 TSC2 CSNK1D TSC1 CSNK1G1 AXIN1 ROR2 FRAT1 CSNK1A1 CSNK1E CTNNB1 LRP5 NLK MAPK1 LRP6 SOX1 ARHA RYK NFATC2 ROR1 PI4K2A MTOR APC CDK6 CTBP1 BCL9 ARRB2 PPARG LEF1 PRKCB GSK3A MAP3K7 TCF4 DVL1 STM7 DVL2 TCF7L2 PRKCA TCF3 DVL3 RAC1 CCND1 GCKR ATR SIGNALING%WIKIPATHWAYS_20260211%WP3875%HOMO SAPIENS ATR signaling RAD1 RAD9B CHEK1 RAD9A ATRIP RPA3 RPA1 HUS1 ATR TOPBP1 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260211%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis GPC6 COL1A1 COL3A1 SPARC YAP1 SNAI2 EDNRA TEAD4 TWIST1 PBX3 THBS2 TEAD2 TEAD3 NRF2 PATHWAY%WIKIPATHWAYS_20260211%WP2884%HOMO SAPIENS NRF2 pathway ABCC5 HGF NRG1 TGFA SLC2A4 CES2 CES1 NR1C2 SQSTM1 CYP4A11 PTGR1 TGFB1 TXN SERPINA1 SLC6A17 SLC6A16 SLC6A13 HEL126 SLC6A11 SLC5A6 SLC5A7 SLC5A9 CES8 GSTT2 CES3 EPHA3 UGT1A3 HEL-S-10 NQO1 MGST3 GPX3 MGST2 SLC5A3 SLC5A4 SLC2A3 GSTM3 SLC2A2 ABCC3 SLC5A1 HEL-S-128m SLC6A5 SLC5A2 SLC6A7 SLC6A20 SLC6A8 SLC6A9 DNAJB1 SLC5A5 GSTM5 SLC6A1 EGR1 SLC6A2 TGFBR2 SLC2A14 SLC6A19 SLC2A11 UGT2B7 ABCC2 SLC2A10 SLC6A18 SLC2A13 SLC2A12 GSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC5A8 HBEGF RXRA HEL-75 GCLC GSTM2 NFE2L2 GSTA5 GSTA4 CYP2A6 GSTA3 SLC6A3 SLC39A9 UGT1A1 EPHA2 UGT1A9 SLC39A6 AGER SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC7A11 ALDH3A1 FTH1 SLC39A8 SLC2A9 GSTM4 SRXN1 SLC2A6 SLC2A7 SLC2A8 KEAP1 MAFG ME1 SLC39A14 GPX2 HEL-S-25 FTL HEL-S-22 SLC5A12 SLC5A10 HMOX1 UGT1A4 UGT1A7 TXNRD3 MAFF ADH7 GCLM FGF13 HSP90AB1 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5120%HOMO SAPIENS Inclusion body myositis NFKB1 NFKB2 APP PSEN2 SIRT1 PSEN1 GDF8 PSENEN BACE1 ID SIGNALING%WIKIPATHWAYS_20260211%WP53%HOMO SAPIENS ID signaling PAX5 ELK3 ID2 ID3 CCNE1 ID1 PAX8 RBL2 RBL1 RB1 CDK2 PAX2 MYOD1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260211%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGV PIGY PIGM PIGC DPM2 PIGB PIGW PIGA PIGK MPPE1 PIGL PIGF PIGH PIGX CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260211%WP2029%HOMO SAPIENS Cell differentiation index TLX2 HDAC5 STAT3 LEFTY1 TLX1 TLX3 LEFTY2 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260211%WP167%HOMO SAPIENS Eicosanoid synthesis ALOX12 LTC4S PTGS2 ALOX5 ALOX15B ALOX15 ALOX5AP PLA2G5 PLA2G6 PTGS1 PTGIS PLA2G4B PRXL2B PTGES OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP3941%HOMO SAPIENS Oxidative damage response MAPK10 CASP9 CASP3 BAK1 APAF1 TRAF3 TRAF2 TRAF6 C5AR1 MAP3K1 CDKN1C NFKB1 MAP2K4 TNF MAPK13 BAD GADD45A PCNA C1R CDC42 BCL2 CDKN1B C1QB C1QA TNK2 C4B_2 C2 CDKN1A C3AR1 TNFRSF1B BAG4 CR2 TRAF1 NFKBIE CYCS C1QC HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260211%WP4540%HOMO SAPIENS Hippo signaling regulation PLCB4 PRKD3 PLCB1 EGFR SMAD2 PLCB2 FLT1 INSR CDH6 FGFR4 CDH2 CDH16 IGF1R KDR PDGFRA CTNNB1 PRKAA2 MET PRKAG1 FLT3 PRKAG2 PRKAG3 FGFR2 PRKAA1 LEF1 PRKACG EPHA2 PRKAB2 PRKCH PRKCB PRKAB1 GNA11 PRKCE PRKCA NTRK1 TCF7L2 TCF7L1 CDH9 KIT CDH8 PRKAR1B GNAL PRKAR1A CDH4 PRKCI CDH10 PRKCQ CDH11 CDH12 CDH15 CDH17 CDH19 NF2 PRKCZ CDH24 NGFR WWTR1 YAP1 GNAI3 CSF1R NTRK2 ARHA GNAS MTOR CDC42 FGFR1 FLT4 CDH18 LATS1 PLCB3 TEAD4 LATS2 RAC1 TEAD2 TEAD3 FGFR3 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CCND2 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 TFAP2A WNT5B WIF1 SOST LEF1 CCND3 NKD1 NKD2 MAP3K7 DVL1 DVL2 TCF7L2 TCF3 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 MACROH2A2 ATF3 CXXC4 PORCN GSK3B CDK8 WNT2B HNRNPK NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 FRAT1 FRAT2 AXIN2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CDK6 CTBP1 FOSL1 FZD1 RUVBL1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 APC2 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP5172%HOMO SAPIENS Iron metabolism disorders TF PANK2 CYBRD1 HFE2 HAMP HEPH FTL STEAP3 FTH1 UQCRFS1 CP TFRC HFE TFR2 SLC40A1 SLC11A2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260211%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK1 PPP5C TSC2 PPM1D RBBP8 RNF20 MRE11A MDC1 ATMIN RIF1 CEP63 IKBKG KAT5 TRIM28 RAD50 TP53BP1 NFKB1 LMNB2 CDK2 NHEJ1 MAPK12 MAPK13 ATF2 MAPK11 MAPK14 MTOR PRKDC HMGN1 ATM RNF168 NBN ATR SMC1A RNF8 AURKB HEL-S-102 PPP2CA STK11 CDK5 CHEK2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260211%WP80%HOMO SAPIENS Nucleotide GPCRs ADORA2B P2RY6 P2RY4 P2RY2 P2RY1 LPAR4 ADORA2A LTB4R SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260211%WP615%HOMO SAPIENS Senescence and autophagy in cancer SERPINB2 IRF7 CDKN2A SMAD4 INHBA BRAF IGF1 CEBPB IGF1R IL24 SRC INS MAP2K3 MAPK1 MAP2K1 MAPK14 LAMP2 IL6ST MLST8 BCL2 RAF1 ATG3 CDKN1B GABARAPL2 PLAT ATG12 SLC39A2 IGFBP5 SLC39A1 ATG16L1 SLC39A3 AKT1S1 IRF1 IL6R MAP1LC3A MAP1LC3C SQSTM1 IFNG RB1 SH3GLB1 UVRAG ATG10 BMP2 GSK3B HMGA1 CD44 COL1A1 DKFZp762B153 COL3A1 RB1CC1 SPARC TGFB1 CDC25B JUN ING1 COL10A1 GABARAPL1 THBS1 TNLG1B ATG14 ATG5 RNASEL VTN IL6 GABARAP CXCL8 AMBRA1 IFI16 CREG1 RSL1D1 ULK1 MTOR IL3 PCNA MDM2 KMT2A CDKN1A PTEN IFNB1 IL1B BMI1 HRAS CXCL1 CXCL14 IGFBP7 IL1A MMP14 CCL3 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP69%HOMO SAPIENS T cell receptor signaling PAK1 RELA HEL-S-81p GAB2 VAV1 SH2B3 ZAP70 GRAP2 SHC1 PDPK1 LCP2 CARD11 BCL10 MAPK1 FYN MAPK3 NFATC2 LAT ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 RAF1 MAP3K8 MAP3K7 REL PTK2B PRKCQ LCK MAP4K1 MAPK9 MAPK8 CD3G CD3E CHUK CD3D CD8A TRAF6 CRK IKBKG WAS PLCG1 JUN NFATC1 NFKB1 MAP3K14 ITK CRKL PSTPIP1 RIPK2 FYB1 PIK3R2 PIK3R1 CDC42 ICOS CBL NCK1 VAV3 FOS IKBKB CREB1 HRAS GRB2 SOS1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260211%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts GCK GLS UGDH LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 CD36 BMP1 FGFR1 GLUD1 FGFR4 PSAT1 PLCG1 P4HA2 PSPH ALDH18A1 HEL-S-133P ARHA PHGDH P3H4 P3H3 PLOD1 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260211%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PKLR AGXT GLYCTK AQP9 KHK GPD1 LIPE ALDOB PC FBP1 GPD2 PFKL HEL-S-162eP ENO1 HEL-S-68p MGLL HEL-S-165mP PGAM1 HEL-S-49 G6PC1 HEL-S-87p PNPLA2 AQP7 PCK1 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260211%WP2889%HOMO SAPIENS Oxytocin signaling OXTR PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway CASP9 CASP3 APAF1 PINK1 UBE2L6 PARK2 UBE2L3 CASP2 DDC MAPK12 MAPK13 MAPK11 MAPK14 GPR37 UBB SEPT5 LRRK2 SLC6A3 ATXN2 HEL-S-67p CASP6 CCNE1 UBA7 TH EPRS1 SYT11 HEL-117 UBE2J2 CCNE2 UBE2J1 SNCA HTRA2 UBE2G1 UBE2G2 SNCAIP CYCS IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260211%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer VEGFD MMP9 TGFB1 CXCL12 VEGFA IL10 IL13 IL2 IL4 IL6 IL5 CXCL8 CCL5 TNF CCL28 CCL2 CXCL5 CCL20 LGALS9 IL25 REG4 IL12B IL12A IFNG IL23A IL1B IL17F CSF2 IL17D IL17C IL17B CXCL1 VEGFB IL17A VEGFC SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260211%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX11 YES1 WWTR1 H4C9 SRRT FGF7A HIST1H4L SOX12 POU3F1 UTF1 SOX15 ZSCAN10 SOX4 SOX2 TEAD2 POU3F2 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260211%WP531%HOMO SAPIENS DNA mismatch repair PCNA POLE4 RFC2 MSH6 RFC3 RFC4 RFC1 POLD3 MSH2 POLD4 POLE LIG1 PMS2 POLE2 POLD2 POLE3 RPA3 RPA1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260211%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP8 ATP6 COX17 ATP5MC2 ATP5J ATP5MC3 COX7A2 ATP5H COX11 NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 SLC25A14 COX2 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HEL-S-123m SLC25A27 UCP3 UCP2 NDUFA7 NDUFA6 NDUFA5 ZNF183 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COX7B COX4I1 COX6A1 COX8A COX6B1 COX7A1 SDHC SDHD UQCRB SDHB COX3 UQCR11 UQCR10 CYB UQCRH UQCRQ UQCRC1 UQCRFS1 UQCRC2 SURF1 COX1 SDHA SLC25A5 SLC25A4 SLC25A6 UCP1 NDUFA13 COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 NDUFA9 NDUFA12 NDUFA10 COX6A2 HEL-S-271 ATP5IF1 COX7A2L SCO1 ND1 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260211%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ACTA2 ITGB1 MAPK10 ITGB7 NF2 MAPK9 MAP4K1 MAPK8 PAK1 MAP4K2 WWTR1 YAP1 MAP4K3 SRC CTNNB1 CTNNA1 ACTG1 ITGB5 ITGB4 ITGB3 YWHAQ PS1TP5BP1 ITGB8 SGMS1 ITGB6 ACTA1 LATS1 LIMD1 TEAD4 PAK6 PAK4 TEAD2 TEAD3 HEL-S-31 ACTG2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD2 CREBBP FST SMAD4 INHBA EP300 RUNX2 STAT1 TGFBR1 BMP4 DKFZp781O1323 LIF CTNNB1 TNF FKBP1A MAPK3 LEFTY1 LEFTY2 ZFYVE9 EGF ZEB2 LTBP1 ZNF423 BAMBI LEF1 FOXH1 TGIF1 IFNG WNT1 MAPK9 TGFB1 STAT3 TGFBR3 JUN NFKB1 THBS1 ENG SPP1 SMAD1 SMAD6 SMAD9 ITGB6 NOG FOS SKI RUNX3 JAK1 HRAS SKIL TGFBR2 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260211%WP4262%HOMO SAPIENS Breast cancer pathway SHC1 ERBB2 SOS2 SHC4 SHC2 SHC3 EGF RPS6KB2 E2F2 RPS6KB1 NBN DDB2 PIK3R3 RB1 CETN3 GADD45B GADD45G CCND1 ARAF BAX FZD10 FRAT1 FRAT2 CSNK2A1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B GADD45A PIK3R2 PIK3R1 TNFSF11 FZD1 WNT10B WNT10A FZD3 ATM FZD2 FZD5 FZD7 FZD9 ATR FZD8 PTEN BRCA1 BRCA2 HRAS APC2 NCOA1 FGF23 EGFR BAK1 MRE11A BRAF NRAS IGF1 CSNK1A1 WNT7B IGF1R WNT7A RAD50 RAD51 FGF10 CTNNB1 CDK4 MYC AKT3 MAPK1 KRAS MAPK3 MAP2K1 NR3A2 MAP2K2 WNT5B NOTCH2 NOTCH3 NOTCH1 PGR RAF1 LEF1 HES1 DVL1 HES5 DVL2 FGF8A TCF7L2 DVL3 NFKB2 TCF7L1 WNT1 KIT WNT3 WNT4 WNT3A FGF6B GSK3B WNT2B PIK3CD POLK AXIN1 AXIN2 SKP1 JUN WNT16 PIK3CA SP1 LRP5 LRP6 FGF20 FGF22 FGF7 FGF21 FGF8 MTOR FGF9 FGF16 APC CSNK1A1L CDK6 JAG2 E2F3 PARP1 FGF18 FGFR1 FLT4 HEY2 FGF2 FGF7B FGF7A FOS DLL3 DLL4 CDKN1A FGF5C GRB2 SOS1 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260211%WP4331%HOMO SAPIENS Neovascularization processes MMP9 SMAD2 ANGPT1 MAPK9 MAPK8 KITLG TGFB1 RELA CXCL12 RELB TGFBR1 DKFZp781O1323 KDR NFKB1 MAPK1 MAPK3 SMAD1 NOTCH3 NOTCH1 SMAD9 CXCR4 EPHB4 FLT4 EPHB2 DLL4 NFKB2 HIF1A KIT ACVRL1 REL CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260211%WP5603%HOMO SAPIENS Caffeine in myocytes MYL11 TNNT1 ACTA2 MYL3 TNNT3 MYH8 MYH4 MYH7 MYL1 TNNC1 TNNI1 HEL-S-273 HEL-S-108 RYR1 RYR2 ACTG1 TPM3 TPM1 RYR3 PS1TP5BP1 MYH6 ACTA1 MYH13 TNNI2 MYL2 TNNI3 TNNC2 MYH1 ACTG2 MYH2 MYL6 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260211%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine AANAT SPR PAH MAOA ASMT JDP1 PTS PNMT TH DHFR DBH NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IRF7 RELA DDX3X TRAF3 CASP10 MAP3K1 ISG15 TNF IFNK MAPK12 MAPK13 MAPK11 MAPK14 NFKBIA TBKBP1 NFKBIB IKBKE ATG12 MAP3K7 IFNE RIPK1 IFNG TANK MAPK10 MAPK9 MAPK8 OTUD5 CHUK CXCL12 TRAF2 TRAF6 DDX3Y TBK1 DHX58 IKBKG TRIM25 AZI2 SIKE1 RNF125 NFKB1 CYLD PIN1 ATG5 CXCL8 MAVS SNW1 CASP8 RIGI FADD TRADD IFNB1 IKBKB MITA NLRX1 IFNA1 IFIH1 IRF3 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 EBP CYP51A1 SC5D CYP46A1 DHCR24 LBR HMGCR NR1H2 CH25H FDFT1 IDI2 PLPP6 FADS2 SCD CYP7A1 CYP27A1 MYLIP ELOVL5 ACAT2 HSD17B7 TM7SF2 ABCA1 GGPS1 IDI1 ELOVL4 FDPS ELOVL3 MVK HMGCS1 MSMO1 ABCG1 PMVK MVD NR1H3 ACSL1 ELOVL2 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260211%WP623%HOMO SAPIENS Oxidative phosphorylation ND3 ND2 ND5 ND4 ND6 NDUFB10 ATP6 ATP5MC2 ATP5J ATP5MC3 ATP5H NDUFV3 NDUFV2 ATP5MG ATP5MF ATP5ME DMAC2L ATP5G1 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 HEL-S-123m NDUFA7 NDUFA6 NDUFA5 ATP5PB NDUFA3 NDUFA2 ND4L ATP5F1D ATP5F1E NDUFAB1 ATP5PO COXFA4L2 ATP6AP2 NDUFS8 NDUFS3 COXFA4 NDUFA11 NDUFA9 NDUFA10 HEL-S-271 ND1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260211%WP2253%HOMO SAPIENS Pilocytic astrocytoma RAF1 NF1 KRAS NRAS BRAF HRAS PTPN11 GRB2 SOS1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260211%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling GSK3B CREBBP CASP9 PDGFA IKBKG FOXO1 PIK3CA NFKB1 CTNNB1 AKT3 KLK3 MAPK1 KRAS BAD MAP2K1 MTOR NFKBIA MAP2K2 BCL2 RAF1 CDKN1B MDM2 CDKN1A GRB2 CCND1 SOS1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IF2B1 IL23R IL17RC STAT3 IL12RB1 IL12B TYK2 CXCL8 IL23A IL1B IL17F HLA-C TNF CCL20 CXCL1 IL17A CCR6 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260211%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction CALM1 RYR1 MYLK PLCB1 PPP1R14A MYL1 ROCK1 ROCK2 IL13 GDI1 ADRB2 HEL-S-80p ARHA OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260211%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 NFKB1 IKBKB CHUK MAPK1 RELA ITGB3 MAP3K14 SPP1 MAPK3 MAP2K1 ITGAV HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260211%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG3 RB1CC1 ATG12 WIPI1 ATG16L1 MAP1LC3A ATG5 ZFYVE1 ATG16L2 ATG10 ULK2 MTOR ULK1 PIK3R4 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260211%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport CYP8B1 ABCC2 AKR1D1 AKR1C4 SLC27A5 SLC51A HSD3B7 ABCB4 SLC51B ABCB1 BAAT ABCC3 CYP7B1 SLCO1B1 FABP6 SLC10A2 AMACR ABCB11 SLC27A2 ATP8B1 HSD17B4 CYP7A1 ABCD3 CYP27A1 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP496%HOMO SAPIENS Steroid biosynthesis CPN1 HSD17B2 F13B HSD3B1 HSD17B3 HSD17B7 CYP17A1 HSD17B4 HSD17B1 HSD3B2 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260211%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PLCB4 PIK3CD PLCB1 PLCB2 TSC2 TSC1 YAP1 ROCK1 PKN2 PIK3CA AKT3 MAPK1 ARHA MTOR PIK3R2 MOB1A PIK3R1 PKN3 PKN1 PIK3R3 LATS1 PLCB3 TEAD4 LATS2 TEAD2 TEAD3 TRIO SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1A2 MSRB2 CYP1B1 MSRB3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260211%WP2197%HOMO SAPIENS Endothelin pathways CALCA HEL-S-14 MYLK PLCB1 GNAI1 MYL1 CAD HEL-S-7a GNG13 EDNRA RAMP1 GNA15 MAPK1 NPY GNAS MAP2K1 COX2 CALCRL GNB5 ECE1 EDNRB CALM1 ADRB1 NPY1R RIIAD1 ATP2A2 RAF1 ADRA1A EDN1 PRKCA PTGIR LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 CS SLC19A2 NONO SIGNALING LIPIDS%WIKIPATHWAYS_20260211%WP5584%HOMO SAPIENS Signaling lipids PLA2G1B CYP2C8 CYP8B1 COX1 PLCB1 ALOX12 LTC4S PTGS2 CYP2C9 ALOX5 CYP2B6 ALOX15 HPGD CYP7B1 CYP4F2 GPX4 FADS2 PLA1A CYP7A1 EPHX2 PRXL2B CYP27A1 PTGES VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260211%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism HEL-S-53e RXRB CD36 RXRG HEL-S-4 CYP26A1 SULT1A1 SULT2B1 ADH1A CYP26B1 RLBP1 RPE65 DGAT1 SDR16C5 RXRA MAPK1 RDH12 ABCG8 AWAT2 ABCG5 LRAT BCO1 SCARB1 RDH8 ALDH1A3 CRABP2 RETSAT RARA CRABP1 LPL DHRS3 RBP7 RBP4 RBP2 RBP1 RDH5 CYP2E1 ALDH1A2 NR1B3 RDH10 NPC1L1 RARB GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST8SIA5 ST3GAL5 A3GALT2 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 FUT1 ST8SIA1 SLC33A1 B3GALT4 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260211%WP3930%HOMO SAPIENS EDA signaling in hair follicle development BMP1 TNLG7C DKK1 EDARADD DKK4 LTB WNT3 PTCH1 RELB EDAR SHH SOSTDC1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260211%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GHRH GH1 GNRH1 SST IGF1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260211%WP5178%HOMO SAPIENS Disorders of fructose metabolism SLC5A1 HEL-S-53e GLYCTK KHK HEL-S-49 SORD ALDOB G6PC1 FBP1 PFKL SLC2A2 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP707%HOMO SAPIENS DNA damage response CCND2 MRE11A PML RAD50 RAD51 FAS CDK4 MYC CDK2 FANCD2 H2AX CDKN1B HUS1B BBC3 TP53AIP1 PIDD1 CCND3 SESN1 TLK2 TLK1 NBN RFC1 SMC1A DDB2 CCNE2 RRM2B CCNB3 CCNB2 RB1 CCNB1 PMAIP1 ATRIP GADD45B TNFRSF10B CDC2 GADD45G CCND1 RAD52 CDK5 CYCS CHEK2 RAD17 RAD1 CHEK1 RAD9A CASP9 CASP3 APAF1 BAX SFN CASP8 GADD45A PRKDC CDK6 MDM2 CCNE1 ATM ATR CDKN1A BRCA1 CREB1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260211%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients SMAD2 TMEPAI NEDD4 TGFBR2 TGFBR1 ATG16L1 MRNA PROCESSING%WIKIPATHWAYS_20260211%WP411%HOMO SAPIENS mRNA processing SRPK2 PPM1G RNMT YBX1 SUPT5H HNRNPH1 NCBP1 NCBP2 SMC1A SRSF9 TMED10 PTBP1 METTL3 SNRPD2 SNRPD1 HNRPR CLP1 PAPOLA SNRPD3 TXNL4A NONO PSKH1 SNRPN PRP4K CDC40 PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 HNRNPD SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA FUS SNRPB DHX8 CSTF3 CSTF2 PRPF8 SFRS5 SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 WDR57 SFRS3 CLK4 SFPQ LSM2 CLK2 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 DHX16 RBM5 RBM17 PRMT2 PRMT1 PRPF18 NHP2L1 SNRPA1 DNAJC8 SF3B5 SF3B2 DICER1 CSTF2T U2AF1 PABPN1 POLR2A U2AF2 TRA2B SNRPB2 SF3B1 DDX1 SF3A1 SF3A2 HNRNPK SPOP HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRPK1 SRP54 DHX15 PRPF40A SRSF10 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260211%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCB4 PIK3CD PLCD3 PLCB1 PLCD4 PLCB2 RETN RELA CHUK PLCG2 PLCG1 IKBKG PIK3CA NFKB1 IL6 AKT3 CXCL8 MAPK1 TNF MAPK3 MAPK14 NFKBIA PLCE1 IL12B IL12A PLCB3 IKBKB LUNG FIBROSIS%WIKIPATHWAYS_20260211%WP3624%HOMO SAPIENS Lung fibrosis MMP9 CXCL2 CCR2 PDGFA IGF1 CEBPB CCL11 HGF CCL5 TNF SFTPC CCL2 CCL4 TGFA EGF BMP7 NFE2L2 IL12B TERT TIMP1 CALCA TGFB1 CSF3 FAM13A SFTPA2 MT2A KPG_011 ATP11A CTGF RTEL1 DPP9 STN1 CMA1 IL13 MUC5B HMOX1 IL4 IL6 IL5 SERPINA1 CXCL8 SPP1 FGF7 CCR3 ELMOD2 PTX3 SFTPA1 FGF2 GREM1 EDN1 MMP2 IL1B CSF2 SKIL CCL3 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260211%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis GCK HEL-S-162eP PFKL ENO1 ENO2 PFKM ENO3 HEL-S-68p MPC2 PGAM2 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-30 HEL-S-87p HK2 PCK1 SLC2A4 PDHA1 MDH2 GOT2 PKLR ALDOB PC FBP1 SLC2A3 SLC2A2 LDHB MPC1 HEL-S-133P DLAT HK3 G6PC1 HEL-S-32 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260211%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO GOT2 AGXT SLC26A1 PXMP2 HEL-S-133P HAO1 HOGA1 PRODH2 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260211%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FBP1 VEGFA FOXO1 PIK3CA HEL-S-68p KDR MYC HIF1A PGAM1 HEL-S-133P OTUD7B G6PC1 OTUB2 USP37 U2AF2 USP44 SIRT7 MTOR HK2 VHL USP28 USP19 OTUD6B ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260211%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTBN4 KCNQ2 BRSK1 SEMA3A ANK2 L1CAM SCN5A SPTAN1 PRRT2 CSNK2A1 EIF2A CSNK2A2 SCN2A DDIT3 CSNK2B SNAP25 ATF4 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260211%WP2333%HOMO SAPIENS Trans sulfuration pathway pcap MTR CTH GCLM CBS METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases SCARB1 ANXA2 MTTP APOB LDLR APOE LPL ABCA1 LIPG APOC2 LIPC APOA2 PCSK9 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer BIRC5 HEL113 APP AXIN1 HEL-S-89n NFKB1 THBS1 SOCS3 NRG1 YBX3 MAPK1 JUND TNF RIPK2 F2R ERBB3 GCLC ERN1 CTNNA1 IL7R CDKN1B CUL5 APOE BEX3 RNF7 NQO1 HELLS HDAC1 NET1 CARD14 TNFRSF21 RPS6KB1 PKN1 VAV3 HEL-S-7 CDKN1A SQSTM1 HEL-S-102 PTK2B TNFRSF10B TRAF1 HSPD1 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DCTN1 YWHAQ DCTN6 TH PAFAH1B1 DCTN5 DCTN3 HEL-S-1 YWHAG NDEL1 DCTN4 HEL-S-77 YWHAZ DDC PPP2CA HEL2 CDK5 DBH DISC1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260211%WP51%HOMO SAPIENS Regulation of actin cytoskeleton MYLK PIP4K2A VAV1 DOCK1 PDGFRA RRAS2 SOS2 WASF1 EGF FGFR2 RAC3 PXN PIK3R3 STM7 ITGA1 PAK6 PIP5K1A PIP4K2B PAK4 PIP5K1C MYL3 WAS ARHGEF4 RRAS CYFIP2 BDKRB1 PIK3R4 ACTN1 PIK3R2 PIK3R1 GNA13 RAC1 APC2 CD14 FGF23 EGFR PAK1 MYL1 FGFR4 ARHGEF7 PDGFA BRAF NRAS CHRM1 FGF10 BDKRB2 MAPK1 KRAS MAPK3 MAP2K1 MAP2K2 RAF1 ACTG1 HEL114 F2 FGF8A ARHGAP35 CFL2 FGF6B PFN1 EZR HEL-S-15 PIK3CD CHRM2 CHRM3 CRK ROCK1 ROCK2 GNG12 PIK3CA TMSB4X LIMK1 ARHA FGF20 FGF22 FGF7 FGF21 FGF8 F2R FGF9 FGF16 APC FGF14 CDC42 PIK3R5 FGF13 FGF18 FGF12 IQGAP1 FGFR1 PIK3C2G PIK3C2A PIK3C2B PS1TP5BP1 FGF2 FGF7B NCKAP1 CHRM4 FGF7A CHRM5 HEL70 MYH10 RDX RASSF7 ARHGEF1 ARPC5 MAPK6 SSH2 SSH3 MAPK4 BRK1 FGF5C PIP5KL1 FGD1 CSK WASF2 BAIAP2 MOS SOS1 ABI2 FGFR3 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC2 NFE2L2 MAPK8 HEL-S-22 NQO1 CES1 ABCC6 JUN ABCC3 FOS HMOX1 ABCG2 EPHX1 MAPK12 MAPK13 SRXN1 MAPK11 GCLM MAPK14 NQO2 KEAP1 GCLC IL26 SIGNALING%WIKIPATHWAYS_20260211%WP5347%HOMO SAPIENS IL26 signaling MMP9 ACTA2 RORC DCSTAMP SMAD2 MAPK9 MAPK8 CASP3 RELA STAT1 STAT3 BAX IL10 JUN NFATC1 PIK3CA TYK2 ATP6V0D2 SOCS3 IL6 CXCL8 MAPK1 TNF DDIT3 MAPK3 MAPK14 NFKBIA COX2 CCL20 IL33 TNFSF11 EPHA3 DEFB4B MPO CTSK IL10RB IL1B CSF2 JAK1 IL20RA IL17A IF2G MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260211%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IRAK1 TIFA TLR4 UBE2V1 MYD88 TRAF6 TLR1 JUN NFKB1 TLR10 TLR5 HEL-S-71 TLR9 TLR8 TLR7 IL1A HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260211%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells KIR2DL1 KIR2DL3 ELF3 NLRP7 NLRP2 VAV1 PLCG1 PRKCA LCP2 IFNG CSF2 HLA-C TNF RAC1 FYN LAT TYROBP PRKCQ SYK PTPN6 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260211%WP170%HOMO SAPIENS Nuclear receptors NR1D2 RORC RORA RXRB NR2F6 RXRG NR2E1 NR2F1 NR0B1 NR5A2 NR1H2 NR1C1 NR1A2 RXRA NR1I3 NR1i1 NR5A1 ROR1 NR2F2 NR3A2 NR1i2 PGR RARA NR2C2 NR2A1 PPARG NR3C1 ESRRB NR1C2 NR1B3 NR1H3 THRA ESRRA RARB FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260211%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA4 LMF1 LDLR PLTP GPIHBP1 APOA5 APOC2 LPL LIPC APOA2 SEL1L SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260211%WP15%HOMO SAPIENS Selenium micronutrient network SELENOK PTGS2 RELA INSR CRP HEL-S-97n FLAD1 PRDX3 PRDX5 INS HEL-S-2a TNF GPX1 CCL2 HEL-S-44 HEL-75 SCARB1 APOB SERPINA3 LDLR SAA4 HBB MTR PLAT PLG HEL-S-302 SELENOF MPO SELENOI SELENOH ABCA1 SEPHS2 FGA HBA2 GPX6 F2 PTGS1 SELENOO HEL-S-78p NFKB2 F7 SELENON IFNG SELENOM ALB SELENOP SAA1 SELENOW SAA2 GPX4 SELENOV SELENOT MSRB1 SELS GPX2 ALOX5 ALOX15B ALOX5AP DIO1 CBS TXN NFKB1 TXNRD3 IL6 CTH XDH GPX3 TXNRD2 IL1B KMO KYNU DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260211%WP5195%HOMO SAPIENS Disorders in ketolysis OXCT1 HMGCS1 ACAT1 ACAT2 BDH1 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260211%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 HFE2 HAMP BMP6 ID1 HFE TYPE 2 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4241%HOMO SAPIENS Type 2 papillary renal cell carcinoma ELOC BIRC7 CREBBP TGFB1 EP300 TFEB VEGFA CTSK SETD2 FH CADM2 DVL2 ARNT2 CDKN1A PRCC RBX1 COL21A1 EGLN1 HIF1A EGLN3 EGLN2 VHL TGFA SFPQ BENZENE METABOLISM%WIKIPATHWAYS_20260211%WP3891%HOMO SAPIENS Benzene metabolism EPHX1 DHDH NQO1 GSTM1 MPO CYP2E1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4224%HOMO SAPIENS Purine metabolism and related disorders XDH ADA DGUOK HPRT1 TPMT RRM2B ADSL HEL-S-70p PNP MOCOS AMPD1 PFAS PAICS APRT AOX1 IMPDH1 ADSS 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260211%WP5546%HOMO SAPIENS 22q11 2 distal CNV SDF2L1 CAMK2A NEDD4 PPIB RPS15 RPS14 RPS17 RPS16 RPS18 RPS10 RPS13 RNF19B RPS12 VPREB1 RPS9 CWC22 AQR RPS7 RPS8 CRNKL1 RPS5 PDIA4 RAB36 DNAJB11 RPSA PPIE RPS6 SNRNP200 GNAZ CD79B UBA6 CABP1 CD79A AK8 CWC15 TDRD3 GGTLC2 ZNF280A RPS15A HEL-S-107 RPS19 ARIH1 RPS3 CCDC116 BUD31 RPS2 PLRG1 YDJC RBM22 LRP4 PPM1F RNF113A RILP UGGT1 RPS26 PPIL1 CDC5L RPS28 IGLL5 XAB2 CHEK1 RPS29 YPEL1 PPIL4 RPS20 PPIL6 RPS21 RPS24 RPS23 IGLL1 PARK2 UBE3A UBE2L3 HEL-S-89n IQUB HEL-S-99n ROPN1L RSPH6A PDIA2 DNAJB13 NME5 DYDC1 RSPH9 RSPH3 MDM2 XBP1 RSPH14 SNRPD2 SNRPD1 SNRPD3 PAK1 SNRPG SNRPE SNRPF CAMK1 SNRPB FAU PRPF8 MAPK1 WDR57 HEL-S-125m DHX16 RPS11 RPS27A SNRPA1 SF3B5 SF3B2 SNRPB2 SF3B1 SF3A1 ELOC SF3A2 PHF5A HYOU1 RBX1 SNW1 CANX BCR SOX9 CBL PTPA CAMK4 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260211%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy STX1A CAMK2A DAG1 RAB1A SCN8A ZNF547 TRAPPC3 PRRT2 GIGYF1 TRAPPC6B KCNQ5 NEDD4 AKAP5 SCN2A SCN4B RAB11A SNAP25 KCNQ2 CALM1 KCNQ3 FGF13 FGF12 PRKCE BACE1 VAMP2 MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism CYP11A1 SRD5A2 HSD17B2 HSD3B1 HSD17B3 SULT1A1 UGT1A1 CYP17A1 HSD3B2 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation NCKAP1L VAV1 GATA2 KLF1 CSF1 CD34 NFATC2 MYB NOTCH1 MUC1 CXCR4 RUNX1 SPI1 ITGB3 LEF1 ITGA2B XB KITLG CSF3 EPO TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 GATA1 ABO MXI1 NFE2 IL6 IL5 RIOK3 NR1A2 MHC2TA FLI1 ARHH GP9 TPO HES6 IL3 PIM1 LYL1 FOS IL1B CSF2 ACVR1B FOSB IL1A EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260211%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 IL1B PRKAR1B PRKAR1A H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260211%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CSRP2 CTNNB1 CDK4 SOX4 RB1 PMAIP1 MACROH2A1 CCND1 MED1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260211%WP5604%HOMO SAPIENS Sickle cell disease HBA2 TLR4 IL18 HBB IL1B BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260211%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation SLC10A2 LDLR FGF8A ABCB11 MAPK1 FGFR4 ABCG8 MAPK3 ABCG5 FXR1 CYP7A1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP581%HOMO SAPIENS EPO receptor signaling RAF1 EPOR STAT1 STAT3 CISH EPO SRC SHC1 SOCS1 IRS1 PTPRC MAPK1 STAT5B MAPK3 PTPRU MAP2K1 GRB2 MAP2K2 SOS1 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260211%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGER1 PIK3CD PTGER3 EGFR PTGS2 BRAF NRAS SRC PIK3CA AKT3 MAPK1 KRAS PTGER4 MAPK3 HRAS PLA1A PTGER2 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260211%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer EGFR STAT3 MAPK1 MAPK3 JAK1 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260211%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL6 STAT2 HEL-S-10 STAT1 STAT3 JAK1 IL10 IL10RB IL10RA IL1A CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260211%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer PIK3CD EGFR NRAS IGF1R INS PIK3CA CDK4 AKT3 IRS1 ERBB2 CDK2 MAPK1 KRAS MAPK3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 PIK3R5 CDK6 RAF1 CDKN1B PIK3C2G PIK3C2A PIK3C2B CCNE1 PIK3R3 CDKN1A HRAS CCND1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260211%WP2855%HOMO SAPIENS Dopaminergic neurogenesis HEL-S-53e TGFB1 ASCL1 STAT3 CDKN1C NKX2-2 SHH DDC GBX2 MSX1 SOX2 FGF8 NKX6-1 PITX3 EN2 EN1 LMX1A LMX1B OTX2 FOXA2 SLC6A3 TH NEUROD1 NEUROG2 SLC18A2 WNT1 RET GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260211%WP2261%HOMO SAPIENS Glioblastoma signaling CDKN2A CCND2 EGFR EP300 NRAS BRAF FOXO1 IGF1R SRC PDGFRA PDPK1 CDK4 AKT3 IRS1 MAP2K3 ERBB2 CDK2 MAP2K4 MAPK1 KRAS MET MAPK3 MAP2K6 MAP2K1 MAP2K2 ERBB3 RAF1 CDKN1B FGFR2 PRKCH PRKCB PRKCA RB1 CDKN2B PRKCI PRKCQ CDKN2C CCND1 SPRY2 PIK3CD MAP2K5 PRKCZ TSC2 TSC1 ARAF PLCG2 PLCG1 MSH6 PIK3CA ERRFI1 PIK3R2 PIK3R1 CDK6 MDM4 FGFR1 PIK3C2G FOXO3A FOXO4 PIK3C2A NF1 MDM2 PIK3C2B CCNE1 ATM CBL CDKN1A PTEN BRCA1 BRCA2 HRAS GRB2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260211%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC3A1 SLC6A19 SLC6A20 SLC36A2 CLTRN SLC3A2 SLC7A7 SLC1A1 SLC7A9 JOUBERT SYNDROME%WIKIPATHWAYS_20260211%WP4656%HOMO SAPIENS Joubert syndrome PCM1 MRE11A OFD1 SHH RAD50 PDE6D PDE6A FLNA PDE6G INVS NPHP3 ZNF423 RHEB DVL1 SUFU RAB8A DVL3 CEP164 BBS9 BBS7 BBS5 CEP290 ATF4 BBS4 MYO6 KAT5 RP2 TMEM216 CEP104 ARL3 ARHA ARL13B TMEM67 INPP5E MTOR BBS2 NEK8 BBS1 CETN2 CCP110 AHI-1 PARP1 ARR3 TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP41 CEP97 CC2D2A ARMC9 ATM RPGRIP1L TMEM138 ARL2 NPHP1 PCNT PIBF1 RAB3IP CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 B9D1 B9D2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 ASL OTC NAGS GLS2 ASS1 ARG1 SLC25A13 GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5292%HOMO SAPIENS Glycosphingolipid metabolism B3GALT2 B3GALT1 B4GALNT1 B4GALT4 B3GNT5 ST3GAL5 A3GALT2 GBA2 UGT8 UGCG NEU3 NEU4 A4GALT GLA B4GALT5 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260211%WP5294%HOMO SAPIENS Sildenafil treatment GUCY1A2 GSK3B PDE4A TFAM PDE4B GUCY1B1 PARK2 HEL-S-162eP PDE4D NRF1 AKT3 PRKG1 PPARGC1A NOS2 PDE5A ZNF746 SPINAL CORD INJURY%WIKIPATHWAYS_20260211%WP2431%HOMO SAPIENS Spinal cord injury TLR4 MMP9 CXCL2 MBP CCR2 BDNF OMG GFAP PLA2G2A FKBP1A CCL2 CDKN1B C1QB SLIT2 EPHA4 PLA2G5 PLA2G6 TNLG7A IFNG RB1 NTN1 APEX1 CDC2 MIF CCND1 CCNG1 RGMA TGFB1 FCGR2A IL2 PLXNA2 IL4 CXCL8 GADD45A SELP EFNB2 NOX4 AIF1 AQP1 LTB PPP3CA RAC1 EGR1 ANXA1 MMP12 ZFP36 IL1A SEMA6A PDYN BCAN KLK8 EGFR BTG2 HEL113 NCAN AQP4 PRB1 PTGS2 PRB2 TACR1 VCAN TNFSF13 GAP43 CD47 ACAN SLIT1 SLIT3 LILRB3 GRIN1 CDK4 MYC CDK2 MAPK1 TNF MAPK3 CSPG4 GJA1 RTN4 PRKCA IL1R1 COL2A1 GDNF E2F5 RTN4R LEP NGFR CASP3 ARG1 COL4A1 ROCK2 LTB4R IL6 ARHA NOS2 SOX9 CDC42 FOXO3A ROS1 RHOB XYLT1 FOS IL1B CHST11 CXCL1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260211%WP500%HOMO SAPIENS Glycogen synthesis and degradation GSK3B PPP2R3A PPP2R2C PPP2R2B PYGB PHKG2 PYGM AGL PHKB PHKA1 PHKA2 HK2 CALM1 PPP2R1B PPP2R1A GYS2 GYS1 PPP2R2A PPP2R5E GYG1 GSK3A PPP2R5B PPP2R3B PPP2R5A PPP2R5D PPP2R5C PTPA HK3 PYGL PPP2CA ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260211%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation ATP1A1 COA3 AS3MT UQCRFS1 HEL-S-44 SDHA HEL-S-21 ND1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS1 PTGS2 EPHX2 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260211%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome CAMK2A ITGB1 PAK1 CTNND2 ARHGEF7 GRIN1 RAP1A DLG4 HCN1 SPAAR ARHGAP44 SHARPIN LZTS3 ADGRL1 CDC42 SPTAN1 GRIA2 PS1TP5BP1 SHANK3 MAP3K7 GRIN2B SYNGAP1 DLGAP1 HRAS BAIAP2 HOMER1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260211%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TOMM70 IRF7 AGTR2 REN TRAF3 TRAF6 TBK1 TMPRSS2 NFKB1 CTSL MAVS RIGI ACE2 PHB2 NDUFB9 ACAD9 AGTR1 TLR7 NDUFAF1 IKBKE ECSIT TICAM1 NFKB2 CGAS NLRX1 MITA IFIH1 IRF3 TLR3 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260211%WP4630%HOMO SAPIENS Measles virus infection TLR4 IRF7 CCND2 STAT2 TYK2 NFKBIA NFKBIB IKBKE CDKN1B OAS1 OAS2 CLEC4M BBC3 OAS3 IRF9 CCND3 IFNA6 IL12B MAP3K7 IL12A CCNE2 PIK3R3 STAT5B JAK3 CCND1 IL2RA IL2RB CD46 MAPK10 MAPK9 IL2RG MAPK8 CD3G CD3E STAT3 CD3D EIF3S3 BAX FCGR2B CSNK2A1 CSNK2A3 CSNK2A2 IL2 ADAR CASP8 CSNK2B PIK3R2 PIK3R1 HEL-S-103 FADD HEL-S-72p CCNE1 EIF2AK2 TRADD IKBKB JAK1 HSPA2 IFIH1 IRF3 IL1A IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 BAK1 RELA STAT1 IFNA21 TRAF3 IF1AA9 FAS CDK4 TNFAIP3 IFNA8 CDK2 MX1 LNIR CD209 BCL2L1 BCL2 RCHY1 RAB9A RAB9B TNFSF6 IFNA7 NFKB2 EIF2S1 CYCS IRAK1 PIK3CD IRAK4 CASP9 MYD88 TP73 CASP3 CHUK APAF1 TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 MAVS RIGI IFNA2 BAD TLR9 TLR7 CDK6 HEL70 FOS IFNB1 IL1B EIF2AK1 EIF2AK4 IFNA1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260211%WP5314%HOMO SAPIENS Lactate shuttle in glial cells LDHB SLC16A7 SLC1A2 SLC4A4 SLC16A3 HEL-S-133P NUDT14 CA4 HEL-76 SLC2A3 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260211%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain RAF1 MAP2K5 YAP1 AMOT PIK3CA NFKB1 MAP2K3 MAP2K4 MAPK1 ARHA RAC1 MAP2K6 MAPK3 MAP2K1 MTOR MAP2K2 TRIO MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260211%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYLK HEL114 LPP ITGB3 MFAP5 PLCG1 JUN ITGAV PXN TJP1 CREB1 MAPK1 MAPK3 MYL2 PRKCQ ACTN1 POLYOL PATHWAY%WIKIPATHWAYS_20260211%WP690%HOMO SAPIENS Polyol pathway KHK SORD ALDOB AKR1B1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP2571%HOMO SAPIENS Polycystic kidney disease pathway SLC12A2 CFTR ADCY6 FLT1 NRAS BRAF IGF1 WNT7B IGF1R PDE1A WNT7A SRC KDR CTNNB1 MYC ERBB2 PRKAA2 TNF KRAS MAPK3 MAP2K2 WNT5B PRKAG1 PRKAG2 EGF PRKAG3 PRKAA1 PRKACG PRKAB2 RHEB PRKAB1 GNA11 DVL1 DVL2 DVL3 WNT1 KCNN4 WNT3 WNT4 WNT3A STK11 CCND1 VEGFB GSK3B WNT2B TSC2 GNAI1 TSC1 FZD10 PLCG2 WNT16 GNAI3 JUN PKD1 SFRP4 GNAS MTOR SSTR2 FZD4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT9B FZD5 RPS6KA1 FZD7 WNT9A FZD9 WNT8A FZD8 FOS WNT8B IKBKB HRAS EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260211%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ALOX12 LTC4S ALOX5 ALOX15B ALOX15 KPG_011 HEL-S-298 EHHADH HPGD FPR2 CYP4A22 LTB4R NR1C2 NR1C1 TRPA1 CYP4F2 CYP4A11 TRPV1 PTGR1 CYP4F12 ACOX1 ACOX3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260211%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH3 NOTCH1 MAML3 JAG2 PSEN2 ADAM10 CHUK DLK2 LEF1 MFAP1 PSEN1 MFAP2 HES1 DNER DLL3 DLL4 RRAS MAML2 MAML1 RBPJ NOTCH2 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260211%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 TLR4 EBI3 GPR183 CRP TNFSF13 FOXO1 ISG15 IFITM1 MFGE8 CCL19 PTPRC TNF PAX5 ZEB2 CCL21 CXCR4 CD40 CD80 CD82 CD79A BACH2 IFIT2 C4A BLNK IRF4 CD19 CCR7 FCRL5 IRF8 TNLG7A IL12A CXCR5 CD1D SLAMF7 HEL-S-62p SH2D1A CD40LG IFNG CR2 CR1 MS4A1 CD22 IL-21 CXCL12 BCL6 TBX21 IFNAR2 IL10 IL2 IL4 IL6 BCR SYK TLR7 PDCD1 ICOS ICOSLG PRDM1 SELL CD69 HEL-S-72p XBP1 TMSB10 ITGAX MAF CXCL13 BTLA CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260211%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response ITGA4 SELP ITGB1 KNG1 SELPLG HEL-S-62p IL6 CXCL8 C6 C7 TNF VCAM1 IL1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260211%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders UMPS RRM2B DPYS DHODH NT5C3A HEL74 TYMP HEL-S-29 RRM1 RRM2 TYMS DPYD GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260211%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GABBR2 CASR GRM2 GPRC5A GRM4 GPRC5D GRM8 GPRC5C GRM3 GRM6 COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260211%WP545%HOMO SAPIENS Complement activation C1R MASP2 MASP1 CFD C1QB C1QA C4B_2 C2 C4A C8A CFP HEL-S-62p C6 C7 C8G C9 CD55 C1QC ENERGY METABOLISM%WIKIPATHWAYS_20260211%WP1541%HOMO SAPIENS Energy metabolism GSK3B MEF2C MEF2B MEF2D EP300 CAMK2G FOXO1 NR1C1 RXRA PRKAA2 ATF2 MAPK14 PRKAG1 PRKAG2 PPP3R1 PPP3R2 PRKAG3 PPARGC1B TFAM PRKAA1 PPARG FOXO3A UCP3 HDAC1 UCP2 SIRT1 SIRT3 PRKAB2 GABPA PRMT1 PRKAB1 NRF1 NR1C2 CREB1 PPP3CA PPARGC1A PPP3CC TFB1M TFB2M NCOA1 PPRC1 ESRRA MED1 MYBBP1A CAMK4 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260211%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes KCNJ2 HCN2 TMSB4X ERG GJA1 HAND2 IGF1 HCN4 KCNE1 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260211%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling ANGPT2 BIRC5 HIF1AN BNIP3L ANGPT1 PTGS2 BAK1 BAX EPO VEGFA PFKL HEL-S-68p BCL2A1 HEL-S-30 NOS2 BNIP3 TGFA BCL2L1 PDHA1 IGFBP1 SLC2A3 EDN1 IGFBP2 HIF1A EGLN1 HEL-S-133P PMAIP1 MCL1 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260211%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA NTRK2 AKT3 SORT1 KIDINS220 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260211%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan NADSYN1 TDO2 NMNAT1 HEL-S-90n HAAO KMO KYNU AFMID T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260211%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling GSK3B CALM1 CD8B1 DYRK2 CD8A PLCG1 CSNK1A1 ZAP70 GSK3A NFKB1 IL2 PRKCA PTEN PPP3CA ITK FYN NFATC2 NFKBIA LCK CTLA4 DYRK1A PTPN6 PDCD1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260211%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO3A1 SLC16A2 SLCO4A1 SLCO1A2 SLC16A10 SLCO1C1 SLC7A5 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260211%WP405%HOMO SAPIENS Eukaryotic transcription initiation TAF5 GTF2B GTF2H2C_2 TAF9 CCNH GTF2E1 GTF2E2 GTF2H2 GTF2F2 POLR2B GTF2H3 POLR2F POLR2G POLR2H ERCC2 POLR2I POLR2J MNAT1 POLR2K TAF13 POLR3B POLR3D TAF7 TAF6 POLR3H TBP POLR3K POLR1A POLR1D HEL-S-28 TAF12 CDK7 POLR2C POLR2A POLR3E ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway SERPINB2 EGFR POLK TGFB1 EP300 MYOF BAX JUN SLC7A5 SRC UGT1A4 IL2 AHRR UGT1A7 JUND TNF CAP2 PTGES3 MGST1 NFE2L2 CDKN1B CES3 UGT1A3 NQO1 CYP1A2 CYP1B1 CDC37 UGT1A1 UGT1A9 IGFBP1 CYP1A1 IL12B HES1 IL12A JUNB AIP ALDH3A1 IFNG IL1B AHR IL17B NCOA1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation CPT2 ACADS ACSL3 ACADM PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260211%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFAT5 BATF CD8B1 CD3G STAT3 CD3E CD3D CD8A JUN ZAP70 NFATC1 HLA-DRB1 NFKB1 HLA-A PDCD1LG2 IFNG NFATC3 NFATC2 PTPN11 NFATC4 LCK PDCD1 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP23%HOMO SAPIENS B cell receptor signaling HCLS1 CAMK2A RELA GAB2 BRAF VAV1 VAV2 FOXO1 SHC1 PDPK1 MYC CARD11 BCL10 MAPK1 PTPRC FYN MAP2K6 NFATC3 NFATC2 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 TEC PTPN6 RAF1 CD79B CD79A BLNK CD19 PRKCB MAP3K7 STM7 GTF2I CR2 PIP5K1A REL PIP5K1C BLK BTK CD22 LCK GSK3B MAP4K1 MAPK9 MAPK8 CHUK BCL6 PLCG2 CRK IKBKG PLCG1 JUN NFKB1 MAX RASGRP3 CRKL INPP5D LYN SYK PIK3R2 PIK3R1 CDC42 RAPGEF1 CD81 LAT2 DAPP1 PTPN18 TIEG2 PIK3AP1 CBL RPS6KA1 NCK1 GSK3A IKBKB CREB1 MAPK4 RAC1 HRAS GRB2 SOS1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260211%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2A ITPR2 CYP21A2 AGTR2 PLCB2 STAR CALML6 REN CALML3 CALML4 CAMK1 CAMK2G CMA1 ATF1 ATF2 CYP11B2 AGTR1 HSD3B2 CYP11A1 CALM1 CREB3L3 CREB3L4 HSD3B1 CTSG CAMK1D CAMK1G CREB3L2 CREB3 CREB1 CREB5 CAMK2D ATF6B CAMK4 ATF4 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma EGF RAF1 TSC2 STAT3 TSC1 NRAS EREG BTC RHEB TYK2 PTEN AKT3 KRAS SOS2 JAK1 HRAS RPTOR JAK3 MTOR GRB2 TGFA SOS1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260211%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ NFKB1 RAF1 RRAS IKBKB CHUK MAPK1 MAP3K14 MAP2K6 TRAF6 MAP3K1 NFKBIA IKBKG SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260211%WP3944%HOMO SAPIENS Serotonin and anxiety related events FOS ARC PLCD4 NLGN1 5HT1A CRHR1 PLEK PPP3CA CRH HTR2A PRKCB SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260211%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction TOMM70 NLRP3 TERF2IP REN TRAF3 TRAF6 SIRT6 RPS6KA1 ECSIT NDUFAF2 NFKB1 IL18 IL6 TERF2 MAVS TNF NLRX1 MITA ACE2 ACAD9 NDUFAF1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260211%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle EIF4E IFRD1 ADAM10 NR4A3 VEGFA HEL-S-52 IL18 IL1R1 IFNG CYR61 DUSP14 HBEGF JUND EIF4EBP1 GDF8 ANKRD1 MYOG ATF3 IL1A OVARIAN INFERTILITY%WIKIPATHWAYS_20260211%WP34%HOMO SAPIENS Ovarian infertility CCND2 TSC2 TSC1 PRLR CEBPB RAD51 CDK4 SYNE2 NR1i1 NR5A1 TBP MTOR NR3A2 NCOR1 PGR CDKN1B FSHR ATM FMR1 GJA4 LHCGR FIGLA DAZL GDF9 DMC1 CREB1 ZP3 ZP2 EGR1 SMPD1 PTGER2 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260211%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets FLT3LG ID2 STAT3 RUNX2 SPI1 IKZF1 IRF4 IRF8 TCF4 CSF1 BATF3 CSF2 TPO TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260211%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDKN2A ACTL6B EZH2 ACTL6A CDK4 PTCH1 EED SMARCD1 CDK6 SMARCC1 SMARCA4 SMO SMARCD2 ARID1A SMARCC2 SMARCD3 SUZ12 GLI3 ARID1B RB1 H3F3B GLI4 RBBP4 DPF1 DPF2 DPF3 SMARCE1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260211%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260211%WP288%HOMO SAPIENS Nod like receptor NLR signaling MAP3K7 MAPK8 IKBKB CHUK RELA CD40 IKBKG EPHB2 ERBIN BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260211%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling CDKL5 MEF2C FRS3 CAMK2A DOK5 KCNN2 DOCK3 KCNA3 NCAM1 ARHG SIRPA SH2B1 RANBP9 MARCKS VAV2 BDNF SRC SHC1 KSR1 PDPK1 EIF4EBP1 PRKAA2 FYN SHC4 YBX1 SHC2 PTPN11 SHC3 NFATC4 NFKBIA EIF4E GRIA2 RPS6 RPS6KA5 GRIA3 RPS6KB1 SQSTM1 ACACB STAT5B PTK2B PTPRF MAPK10 MAPK9 TSC2 MAPK8 EIF2S2 STAT3 CRTC1 MAP3K2 CSNK2A1 RAP1A GRIP1 PIK3R2 PIK3R1 RASGRF1 CYFIP1 GRIN2B IKBKB RAC1 HRAS IGF2BP1 RELA STAT1 CDH2 MAP3K1 CAMK1 GRIN1 CTNNB1 CDK5R1 RPS6KA3 IRS1 MAPK1 MAPK3 MAP2K1 MAPK14 MAP2K2 ADAM17 RAF1 PRKAA1 NCF1 NTRK1 NTF3 NTRK3 PPP2CA TIAM1 EIF2S1 CDK5 GSK3B HEL-S-15 MAP2K5 NGFR EEF2 CASP3 CHUK TRAF6 PLCG1 IKBKG JUN NFKB1 MAPK7 SH2B2 LINGO1 NTRK2 SORT1 KIDINS220 BAD MTOR APC CDC42 NCF2 FOXO3A GABRB3 RPS6KA1 NCK2 NCK1 VAV3 NGF CREB1 FRS2 CNR1 GRB2 SYN1 CAMK4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260211%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis BCL2L1 BCL2 FADD CASP9 CASP3 BBC3 APAF1 BAX TNFSF6 TNF MAPK12 CASP8 MAPK13 BAD MAPK11 MAPK14 MCL1 BCL2L11 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260211%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP2C8 PTGS2 CYP2C9 CYP1A2 ALOX15 EPHX3 ALOX12B PTGS1 CYP2C19 CYP3A4 CYP4A11 GPX4 ALOXE3 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260211%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 MCL1 ZAP70 TAR SYNDROME%WIKIPATHWAYS_20260211%WP5362%HOMO SAPIENS TAR syndrome SLC34A3 ITGB1 EGFR HDAC2 CFTR ANKRD35 EIF4A3 GPR89B AKAP10 SLK SUMO2 MAGOH FURIN NUDT17 HEL-S-76p HLA-B HLA-F HLA-G HLA-E RBCK1 MET SLC22A4 PEX11B CLCN3 BCL2L13 TNFRSF14 FARP2 FLT3 NHERF1 UBE2I POLR3GL CD160 PYM1 CXCR4 PDZK1IP1 POLR3C POLR3F POLR3G SIRT1 MITD1 DDIT4 LAMTOR1 IFNG LCK HFE2 HAMP STAT3 CD3D TXN CCAR2 NFKB1 HLA-A HLA-C PEX19 ZFHX3 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260211%WP455%HOMO SAPIENS GPCRs class A rhodopsin like GPR17 P2RY11 HTR1F ADORA2B OR2F1 F2RL2 OR2A4 GPR18 ACKR3 HRH3 ADRA1B ADRA1A PTGFR NPFFR2 RRH GPR174 PTGDR2 GPR173 GPR171 CMKLR2 CMKLR1 GPR37L1 FPRL2 TRHR TBXA2R PTGDR OR1I1 MC2R PTGIR GALR3 GALR2 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 F2RL1 OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 GPR22 BRS3 CCKAR OPN1LW CCR8 CCR4 GPR39 OR5F1 GPR34 GPR31 NPFFR1 AVPR1A OR5V1 OPN1MW OR3A2 OPRD1 OR10H1 OR10H3 GPR45 GPR68 CCR3 OR10H2 GPR42 OR2AG1 CHML OPRK1 EDNRB P2RY10 P2RY14 NPY1R GPR52 GPR50 GPR4 GPR15 GPR3 GPR6 MC5R F2RL3 OR1C1 GPR65 GPR63 OR2D2 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR87 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 HCAR1 HRH2 OR2B3 DRD5 OR2B2 CCR6 HTR1E HTR1D HTR1B NMUR2 NMUR1 OR7A10 OR14J1 MLNR HTR2B PRLHR OR8D2 OR7A17 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 OR7A5 OR10A4 CX3CR1 OR1E2 NPY4R BDKRB2 OR8B8 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 OR2F2 OPN1SW ACKR4 FFAR1 ACKR2 OR11A1 KPG_010 GPR83 LPAR4 KPG_011 AVPR2 GPER CCRL2 CHRM4 CHRM5 PTGER4 PTGER2 AGTR2 CCR2 GPR75 AVPR1B NMBR CXCR4 C3AR1 PTGER1 PTGER3 GHSR RHO C5AR2 NPY2R FPR1 HTR7 BDKRB1 GPR37 MTNR1A ADRB1 MTNR1B GPR161 DRD1 DRD2 DRD3 DRD4 OPN4 OPN3 P2RY1 CHRM1 ADRA2C ADRA2B MGRA ADRA2A MC3R AGTR1 OXTR ADORA2A HTR5A 5HT1A CNR2 CCR7 CXCR5 HCRTR2 HCRTR1 MC4R CHRM2 CHRM3 OR1G1 ADRA1D GPR32 HTR2A FPR2 P2RY6 HTR4 P2RY4 GRPR HTR6 ADRB3 P2RY2 LTB4R EDNRA CCR5 OR1F1 F2R OR2H1 FFAR3 FFAR2 SSTR2 CCKBR FSHR OR3A3 OR10A5 OR3A1 OR1E1 LHCGR ADRB2 IL8RB CXCR1 CNR1 CXCR3 OR2B6 NTSR1 MC1R P2RY13 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260211%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFG MAFK NFE2L2 MAPK8 SP1 MAFF MAP2K1 MAP2K2 CYP2E1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260211%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 PHF19 CD40 STAT4 ITGAV HLA-DRB1 MHC2TA SLC22A4 TRAF1 BLK CTLA4 IL2RA IL6ST CCR6 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260211%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2 COX1 MB HBB XDH NOS2 AOX1 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260211%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDKN2A EGFR SMAD4 RELA TRAF3 MAPKAP1 NRAS VEGFA IGF1R CTNNB1 PDPK1 CDK4 AKT3 ERBB2 PRKAA2 EIF4EBP1 FKBP1A KRAS RPTOR IRF6 MLST8 TP63 NOTCH2 NOTCH1 EIF4E RPS6KB2 NFE2L2 FGFR2 SESN2 PRKAA1 CSMD3 RPS6 DDIT4 SESN1 RHEB TERT NFKB2 RB1 REL STK11 CCND1 KEAP1 AJUBA TSC2 TSC1 BIRC2 PIK3CA NFKB1 MAML1 CASP8 FAT1 MTOR PIK3R2 PIK3R1 NUMB PIK3R5 CDK6 FADD FGFR1 CDKN1A PTEN RICTOR HRAS TGFBR2 FGFR3 SERINE METABOLISM%WIKIPATHWAYS_20260211%WP4688%HOMO SAPIENS Serine metabolism SHMT1 HEL-S-51e PHGDH TYMS SRR PSAT1 DHFR PSPH CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260211%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 RELA IFNA21 CASP10 IF1AA9 ISG15 IFNA8 CCL5 CCL4 NFKBIA IL33 NFKBIB POLR3GL IKBKE POLR3C POLR3F ZBP1 POLR3G AIM2 ATG12 POLR2L TREX1 IFNA6 POLR3A RIPK3 IFNA7 RIPK1 CHUK TBK1 IKBKG TRIM25 POLR2F RNF125 POLR2H NFKB1 CYLD ATG5 ADAR POLR2K IL6 POLR3B MAVS POLR3D CASP8 RIGI IFNA2 POLR3H POLR3K POLR1C POLR1D FADD PYCARD CCL4L2 TRADD IL18 IFNB1 IKBKB IL1B CGAS MITA NLRX1 POLR3E IFNA1 IRF3 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260211%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 CHD3 HBB GATAD2B MTA2 NR2C2 HDAC1 tal-1 HBG2 LDB1 LMO2 HBD BCL11A HBG1 HBE1 GATA1 KDM1A ZFPM1 KLF1 ZBTB7A PPARGC1A MYB PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260211%WP4022%HOMO SAPIENS Pyrimidine metabolism CDA DPYS TYMP TK1 POLE4 RRM1 RRM2 UCK2 UCK1 UMPS POLR3GL POLR3C POLR3F POLR3G POLR2L TYMS ENPP1 POLR3A POLD3 POLD4 POLE RRM2B ZNRD1 HEL74 ENTPD3 NME2 NME3 CTPS2 CTPS1 POLE2 NME4 POLR2A DCTD POLE3 NME6 NME7 CMPK1 CMPK2 POLR1F UPRT DCTPP1 PRIM2 POLA2 DTYMK DHODH POLR2D NT5M POLR2J3 DUT PNPT1 POLR2J2 POLA1 CAD POLR2B ENTPD1 POLR2G POLR2H POLR2I POLR2J POLR2K POLR3B POLR3D POLR3H ENPP3 POLR3K POLR1A POLR1C POLR1D PRIM1 POLR2C POLD2 POLR3E DPYD GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260211%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein GCG SLC5A1 PCSK1 SLC2A2 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260211%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis KCNQ2 KCNQ3 PTGS1 5HT1A FAAH TRPA1 PTGS2 CACNA1H TRPV1 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260211%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 ETS2 BIRC5 EGF CD81 EGFR STAT3 IGF1 CD63 KDR PTEN IL6 GATA4 HEL-S-102 SPP1 HEL-S-44 ADIPOGENESIS%WIKIPATHWAYS_20260211%WP236%HOMO SAPIENS Adipogenesis MEF2C MIXL1 MEF2B KLF6 STAT2 CYP26A1 MEF2D NR2F1 PRLR CEBPA CEBPB EGR2 KLF5 CEBPD LIF GATA3 GATA2 CYP26B1 KLF15 SOCS3 SOCS1 TWIST1 GATA4 SLC2A4 RARA LIPE NR1C2 TRIB3 HIF1A RB1 PTGIS STAT5B GADD45B PCK2 AHR MIF HMGA1 RORA CFD RXRG WWTR1 TGFB1 STAT3 E2F4 SFRP4 DDIT3 SCD GADD45A GH1 FZD1 WNT10B PPARGC1A NCOA1 LPIN1 LPIN2 LPIN3 STAT1 ID3 FOXC2 IGF1 BMP4 FOXO1 INS FAS CTNNB1 NR1C1 IRS1 RXRA IRS4 TNF WNT5B IL6ST NCOR1 MBNL1 HNF1A BMP1 LPL NR3C1 CELF1 ZMPSTE24 LMNA CISD1 DVL1 RBL2 RBL1 WNT1 NR1H3 BMP2 OSM LEP RETN CNTFR GTF3A BSCL2 ADFP NDN BMP3 PLIN1 FRZB IL6 SPOCK1 SP1 UCP1 GDF10 KLF7 PCK1 NCOR2 NAMPT PPARG PNPLA3 CDKN1A CREB1 ASIP SMALL LIGAND GPCRS%WIKIPATHWAYS_20260211%WP247%HOMO SAPIENS Small ligand GPCRs LPAR1 MTNR1A PTGER1 PTGER3 GPR50 MTNR1B CNR2 S1PR3 PTGFR TBXA2R PTGDR PTGIR S1PR2 S1PR4 PTGER4 CNR1 S1PR1 PTGER2 MONOAMINE GPCRS%WIKIPATHWAYS_20260211%WP58%HOMO SAPIENS Monoamine GPCRs HTR1D HTR1B HTR1F CHRM2 CHRM3 HTR2B ADRA1D HTR2A HTR4 HTR6 ADRB3 CHRM1 HTR7 ADRA2C ADRA2B ADRA2A ADRB1 ADRA1B HTR5A ADRA1A 5HT1A CHRM4 CHRM5 ADRB2 DRD1 DRD2 DRD3 DRD4 HRH1 HRH2 DRD5 HTR1E ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260211%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 AGTR2 TGFB1 REN CTSG CMA1 BDKRB2 ATP6AP2 NR3C2 MGRA BDKRB1 ACE2 CYP11B2 AGTR1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260211%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease ITGA4 SELE ITGB1 ITGB7 SELPLG ITGA2 MADCAM1 VCAM1 SLEEP REGULATION%WIKIPATHWAYS_20260211%WP3591%HOMO SAPIENS Sleep regulation GHRH BTBD9 GHRL STAR HTR2A NPY2R ADA SLC29A1 IL6 HEL-S-2 CHRNB2 UTS2R MRGPRX2 OXTR ADORA2A MTNR1B NLGN1 OXT UTS2 TH NPS NPAS2 FOS DRD1 PTGDR IL18 DRD2 DRD3 DLAT CRH CACNA1I HCRTR2 HCRTR1 PER3 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260211%WP3995%HOMO SAPIENS Prion disease pathway MEF2C CASP3 NCAM1 CTCF EP300 STAT3 CHD2 SMC3 HEL-S-89n NFKB1 PRNP RXRA MAPK1 FYN MAPK3 TBP HEL-S-269 RFX5 HEL-S-125m BCL2 PAX5 BATF RAD21 FGFR1 SPI1 POU2F2 IRF4 BCL11A CREB1 CASP12 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260211%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation TACI TLR4 SMCR8 IFT46 C9orf72 IFT70B WDR26 GPS1 MIEF2 RAB10 RASD1 RANBP9 RMND5A FNIP1 FNIP2 NR1H2 MYO16 MKLN1 GID4 MYO15A DRG2 RPTOR BCL2L11 MLST8 PRKAG2 PRKAB1 IRF8 HEL-S-133P G6PC1 CDC2 MYH2 WWTR1 APP PPP1R14A STAT3 BCL6 BAX YAP1 PARK2 IFT172 BLM IFT74 CLTB GRIP1 ULK1 PRDM1 IFT81 IFT27 IFT25 MED9 RAI1 GPR85 PTEN CLEC16A CARM1 RELA TNFSF13 MYC TNF FOXA1 CRY2 CRY1 PRKAA1 FOXA2 ATG101 TRAF3IP1 RAB8A FLCN IFT52 NR1H3 CFL2 PRKCI PARD3 IFT57 PER1 FLII IFT80 MYD88 RB1CC1 NT5M ARG2 TFEB BIRC2 ROCK1 JUN PARD6B NFKB1 LIMK1 MAP3K14 ARHA MTOR FERD3L HES6 PCK1 ALKBH5 CLTC MAEA DENR CLTA MIGA1 ARMC8 RNF41 TOM1L2 FHOD1 RRAGA PEMT LLGL1 DRC5 SHMT1 CLUAP1 DRC7 DRC8 COPS7A PLD6 RAB39B COPS4 IFT20 COPS6 IFT22 COPS5 DRC1 COPS8 GDI2 CREB1 WDR41 IL1B IFT56 ATPAF2 RMI2 RMI1 TOP3A ITPK1 ETV5 DRC10 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260211%WP5028%HOMO SAPIENS Glycine metabolism including IMDs SHMT1 HEL-S-302 LIPT2 LIPT1 GLDC AMT DLD HSCB LIAS GCSH NFU1 BOLA3 ISCU PI3K AKT SIGNALING%WIKIPATHWAYS_20260211%WP4172%HOMO SAPIENS PI3K Akt signaling GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PKN2 KDR PDGFRA PDPK1 HGF PRKAA2 SOS2 MET RPTOR TGFA BCL2L11 MLST8 PDGFC FLT3 EIF4E EIF4B EGF RPS6KB2 FGFR2 GYS2 GYS1 RPS6 RPS6KB1 RHEB PIK3R3 G6PC1 JAK3 STK11 MCL1 CCND1 IL2RA IL2RB ITGA4 ITGB7 TSC2 IL2RG TSC1 IL2 IL4 SGK1 PIK3R2 SYK PIK3R1 IL3 IL3RA GH1 MDM2 PKN3 PKN1 PTEN BRCA1 IKBKB RAC1 JAK1 HRAS IFNA13 IFNA14 EGFR NTF4 IFNA16 IFNA17 FLT3LG IFNA10 RELA IFNA21 FGFR4 IF1AA9 NRAS VEGFA FGF10 IFNA8 IL7 CSF1 IRS1 MAP2K1 MAP2K2 HEL-S-125m BCL2L1 TCL1B TCL1A PPP2R1B RAF1 CREB3L3 PPP2R1A CREB3L4 KPG_010 CDC37 TNFSF6 DDIT4 EPHA2 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 GNGT2 RBL2 FGF8A OSMR COL2A1 KIT PHLPP2 FGF6B PPP2CA RELN VEGFB OSM VEGFC VEGFD GSK3B XB CSHL1 PIK3CD NGFR CASP9 KITLG GHB3 CSF3 CHUK CSF3R EPO TNR IFNAR2 COL4A2 COL4A1 EIF4E1B COL4A4 COL4A6 PIK3CA IFNAR1 CSF1R NTRK2 EFNA5 EFNA4 CHAD FGF20 FGF22 BAD FGF7 FGF21 FGF8 EFNA1 MTOR FGF9 EFNA3 PCK1 FGF14 EFNA2 PIK3R5 CDK6 IL7R FGF13 FGF18 FGF12 FGFR1 HSP90AB1 FOXO3A ITGB5 G6PC2 ITGB4 FLT4 LAMC2 FGF2 PPP2R5E FGF7B ITGB8 ITGAV FGF7A ITGB6 VWF PPP2R5B PPP2R5A PPP2R5D CDKN1A PPP2R5C IFNB1 NGF ITGA7 ITGA6 FGF5C CREB5 LAMA1 LAMA4 IFNA1 LAMA3 GRB2 THBS2 THBS4 SOS1 THBS3 FGFR3 PPP2R3C TLR4 ANGPT4 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 PRL LAMB2 PPP2R3A EPOR PPP2R2C PRLR PPP2R2B PPP2R2D BDNF EIF4EBP1 GHB2 GHR CSH2 G6PC3 COL6A6 COL6A5 CDKN1B ITGB3 IGF2 ITGA2B CCND3 IFNA6 CD19 LAMC1 IBSP IL6R CCNE2 ITGA1 COL6A1 PCK2 ITGA2 COMP COL4A3 COL9A1 COL9A3 COL9A2 COL4A5 COL1A1 LAMA5 LAMB4 SGK2 THBS1 VTN SPP1 LAMB1 CCNE1 FGF23 TNC FLT1 INSR PDGFA IGF1 IGF1R INS CHRM1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 ATF2 COL1A2 MYB PDGFD BCL2 PRKAA1 PHLPP1 PPP2R2A PPP2R3B PRKCA NTRK1 NTF3 ATF4 LPAR1 CHRM2 IKBKG GNG12 GNG11 NFKB1 GNG13 IL6 GNB2 GNB1 IFNA2 GNB4 F2R GNB3 GNB5 GNGT1 PIK3AP1 CREB3L2 CREB3 CREB1 ATF6B HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260211%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis SYT2 HNRNPL CALM1 CAMK2A BCL2 CCND2 PRL NCAM1 RPS6KA5 RPS6KA1 NRXN1 BDNF NRXN3 NRXN2 PRKCA DRD1 NGF CAMKK1 CREB1 CAMKK2 MAPK1 PPARGC1A MAPK14 CAMK4 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260211%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 RYR1 CCK RYR2 PLCB1 CCKBR DAGLA GNAI1 RYR3 CNR1 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260211%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PANK2 RB1CC1 TSC2 TSC1 FTL WIPI1 WIPI2 ATG5 ATG14 CP RPTOR MTOR ULK1 PIK3R4 DEPTOR MLST8 WDR45 ACACA DCAF17 C19orf12 ATG3 COASY FA2H PRKAA1 ATG12 RHEB ATG16L1 PLA2G6 AKT1S1 ATG101 ATG2A MAP1LC3A SPTLC1 ATG10 STK11 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260211%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P REN CTSG CMA1 PEPTIDE GPCRS%WIKIPATHWAYS_20260211%WP24%HOMO SAPIENS Peptide GPCRs AGTR2 TACR1 CCR2 NPY5R OPRM1 SSTR3 SSTR4 SSTR5 CX3CR1 NPY4R BDKRB2 MC3R AGTR1 OXTR AVPR1B NMBR CXCR4 ATP8A1 TACR2 TACR3 CXCR6 TAC4 CCR7 CXCR5 FPRL2 TRHR C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 CCR10 HCRTR1 NTSR2 CCR1 GHSR MC4R BRS3 C5AR1 NPY2R CCKAR FPR2 FPR1 GRPR CCR8 CCR4 EDNRA AVPR2 AVPR1A GNRHR CCR5 OPRD1 BDKRB1 TSHR CCR3 OPRK1 EDNRB NPY1R SSTR2 CCKBR FSHR MC5R LHCGR IL8RB FY CXCR1 CXCR3 NTSR1 MC1R CCR6 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260211%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome CBX3 RNF8 NIPBL H2AX MDC1 ATM RNF168 ATR METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260211%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer GLS PYCR2 PSAT1 HEL-S-162eP PFKL PSPH ACLY ENO1 HEL-S-68p PGAM1 HEL-S-30 PAICS PDHA1 MDH2 GOT2 FASN SLC16A3 GLUD1 HEL-S-51e ALDOB TIGAR SDHB ACO2 FH RPIA SUCLG2 HEL-S-133P HK3 HEL107 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 ALOX15 EPHX2 VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260211%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases PPP3R1 SMAD4 CHUK RELA NR3C1 MAP3K1 MED14 IKBKG NFATC1 NFKB1 IL6 MAP2K3 IKBKB RXRA PPP3CA NR1i1 TNF MAP2K6 MAPK14 NFKBIA NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260211%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD EPHB6 NGFR F2RL2 PAK1 EPHB1 EPHB3 STAT3 JUN BDNF PIK3CA AKT3 TWIST1 ARHA PIK3R4 PIK3R5 EPHB4 EPHB2 FOS PIK3R3 PAK6 MMP2 RAC1 PAK4 TIAM1 CDH11 ARF1 TRIO KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP304%HOMO SAPIENS Kit receptor signaling MAPK8 KITLG EP300 STAT1 STAT3 GAB2 CRK PLCG1 VAV1 GRB7 SRC SHC1 SH2B2 RPS6KA3 SOCS1 MAPK1 CRKL FYN MAPK3 INPP5D BAD PTPN11 MAP2K1 MAPK14 LYN MAP2K2 TEC PIK3R2 PTPN6 PIK3R1 RAF1 FOXO3A RPS6 CBL GRB10 RPS6KA1 SOCS6 RPS6KB1 MATK PRKCB PRKCA DOK1 KIT STAT5B HRAS BTK GRB2 SOS1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260211%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2 UGT1A4 NAT2 CYP1A2 SULT1A1 UGT1A9 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260211%WP3527%HOMO SAPIENS Pre implantation embryo KLF4 ZFP36L2 SOX8 MXD1 ZFP42 POU5F1 GATA3 GATA2 SIX3 DPPA3 SOX2 TFAP2B IRX5 SOX11 ELAVL1 IRF4 NANOGNB FOXD1 DNMT3L KHSRP MYBL1 ZAR1 ARGFX TCF7L1 DLX2 PADI6 BARX2 LEUTX TPRX1 E2F5 TBX3 DPRX CDX2 ZSCAN4 MACROH2A2 HMGA1 HNRNPAB MTA3 FOXQ1 AQP3 NR3C2 DDIT3 PBX1 SMARCA4 AQP9 ATP1A1 NKX2-1 TEAD4 BATF3 EGR1 MOS FOSB ESRRA ZFP36 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260211%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA4 SCARB1 LDLR PLTP APOE LPL LIPC VLDLR APOA2 DNA REPLICATION%WIKIPATHWAYS_20260211%WP466%HOMO SAPIENS DNA replication RPA4 MCM5 MCM6 PRIM2 POLA2 CDC45 RFC2 POLA1 RFC3 RFC4 CDK2 RPA3 RPA1 PCNA MCM2 GMNN POLD3 RFC1 PRIM1 POLD4 UBC POLE ORC6 ORC3 POLE2 ORC2 POLD2 CDC6 MCM7 ORC1L MCM10 DBF4 CDT1 MCM3 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260211%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways HDAC2 CYP46A1 MBP NR1H2 BDNF EIF4EBP1 PRKAA2 RPTOR DEPTOR BCL2L11 PRKAG1 MLST8 PRKAG2 EIF4E EGF PRKAG3 C1QA RPS6KA5 PRKAB2 RPS6KB1 RHEB PRKAB1 SREBF2 AKT1S1 HMGCS1 ABCG1 PIK3R3 ABCG4 PI3 MAPK10 HAP1 MAPK9 RAB3GAP1 TSC2 MAPK8 TSC1 BAX CASP8 PIK3R4 PIK3R2 PIK3R1 AHI-1 APOE PTEN IKBKB PPARGC1A SIN3A HRAS EGFR SLC12A2 HTT AKT3 MAP2K4 MAPK1 KIF5A MAPK3 MAP2K1 MAP2K2 MAP3K10 BCL2L1 BCL2 RAF1 PRKAA1 HDAC1 NEUROD1 ABCA1 HEL-S-29 REST PIK3CD CYP51A1 CASP3 DHCR7 HMGCR PIK3CA NFKB1 IL6 NTRK2 SP1 GABRG2 BAD BNIP3 MTOR PIK3R5 PIK3C2G PIK3C2A OPA1 PIK3C2B GABRB3 GABRB2 GABRB1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 CREB1 GABRA3 GABRG3 IL1B GABRG1 RICTOR SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260211%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1A2 PAPSS2 PAPSS1 SULT1B1 SULT2A1 SULT1A1 SULT1E1 SULT2B1 SULT1C3 SULT6B1 SULT1C2 SULT1C4 HEL-75 SULT1A4 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260211%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260211%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity MARK1 BAK1 CASP10 MBP FAS CX3CR1 CX3CL1 MFGE8 AXL FCN1 FCN2 C1QB C1QA ITGB3 COLEC11 DIABLO PROS1 TNFSF6 C4B_2 C2 C4BPA C4A C8A HEL-S-62p C3AR1 IFNG MBL2 CR2 CR1 PRKCI PARD3 CYCS C1QC SERPING1 MASP2 MASP1 CD46 CAP1 CFD CASP9 PRKCZ CASP3 TGFB1 PATJ FCN3 APAF1 CFH BAX C4BPB C5AR2 DLGAP5 ATP11A CFI ATP11C C5AR1 SCRIB PLSCR3 PLSCR4 TYRO3 PARD6B LLGL2 PARD6A CRB2 CFP COLEC12 CRB1 PALS1 COLEC10 VTN PARD6G CLU ATP10A C6 C7 DEDD C8G CASP8 C9 ATP8B3 CD59 ATP8B2 CD55 ATP8B1 C1R ITGAM ITGAV ITGAX PLSCR1 HTRA2 MERTK CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260211%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling TLR4 CAMK2A CYP21A2 STAR RELA BRAF CTNNB1 PRKAA2 MAPK1 JUND MAPK3 MAP3K5 TFAP2A MAP2K1 MAPK14 NFKBIA ERN1 BCL2 ACACA RAF1 GJA1 HSD3B1 GNAZ PRKCB GNA11 JUNB TCF4 PRKCA CACNA1H PRKCI PRKCQ GSK3B CASP9 MAPK9 CRHR1 MAPK8 CASP3 GNAI1 TGFB1 PLCG2 PLCG1 TRIM28 NFKB1 JUP IL2 SP1 CXCL8 GNB2 ARHA CRHBP GNB1 KRT1 GNAS IVL CRHR2 GNB3 GNAO1 HSD3B2 KRT14 GNB5 ECE1 CYP11A1 POMC PARP1 FOSL2 FOSL1 ARRB2 SULT2A1 FOS IL18 CREB1 CASP12 CRH FOSB SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260211%WP3947%HOMO SAPIENS Serotonin and anxiety POMC PLCD4 ADRA1A 5HT1A PLEK EEF2K HTR2A PRKCB FMR1 FOS ARC PPP3CA CRH TRPV1 IL1 SIGNALING%WIKIPATHWAYS_20260211%WP195%HOMO SAPIENS IL1 signaling IRAK1 IRAK2 UBE2V1 IRAK4 PRKCZ MAPK9 TAB3 MAPK8 MYD88 RELA CHUK TRAF6 MAP3K1 PLCG1 IKBKG MAP3K2 MAP3K7IP1 JUN NFKB1 MAP2K3 HEL-S-71 MAPK1 MAP2K4 MAP3K14 MAPK3 MAP2K6 ATF2 PTPN11 MAP2K1 MAPK14 NFKBIA MAP2K2 PIK3R2 PIK3R1 IRAK3 NFKBIB PELI1 HSPB2-C11orf52 ECSIT MAP3K7 SQSTM1 IL1R1 IKBKB IL1B REL MAPKAPK2 IL1A PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260211%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYS DHODH TYMP NT5C3A RRM1 RRM2 TYMS CAD ABAT UMPS OTC RRM2B GLS2 HEL74 DPYD OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260211%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL1 FADS1 ELOVL5 SCD5 ELOVL6 FASN ELOVL3 FADS2 SCD ACSL1 ELOVL2 FACL4 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260211%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PDHA1 CS PC SDHA HEL-S-26 OGDH ACLY FH DLD SUCLG2 DLAT HEL-S-32 HEL60 PCK1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36B IL36RN STAT1 IL36G IL1F10 GATA3 SOCS3 CSF1 SOCS1 MAPK1 BCL2L11 IL37 POLR2L ANAPC1 ZNRD1 IL1R1 IL23A POLR1F ARF6 PLCG2 POLR2F POLR2H IL2 POLR2K IL6 POLR1A POLR1C POLR1D CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 TTL IL1RL2 NT5DC4 IL1B CSF2 RAC1 IL1RN MERTK CXCL13 GRB2 IL36A IL1A HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260211%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling EGFR FLT1 RELA INSR FGFR4 BRAF PML CSNK1A1 FOXO1 IGF1R SRC KDR KSR1 SHC1 PDGFRA GAREM2 CTNNB1 MYC AKT3 MAPK1 SOS2 KRAS MET MAPK3 RPTOR MAP2K1 NFKBIA DEPTOR MAP2K2 MLST8 FLT3 ZBTB16 PYGO1 RAF1 BCL9 RARA FGFR2 RUNX1T1 LEF1 EPHA2 RHEB AKT1S1 NR1C2 IL6R NTRK1 TCF3 KIT WNT1 REL CCND1 GSK3B PIK3CD NGFR TSC2 RETN CHUK TSC1 STAT3 IKBKG AXIN2 JUN PIK3CA NFKB1 JUP CSF1R NTRK2 IL6 LRP5 LRP6 ULK2 MTOR APC TTI1 SALL4 FGFR1 FLT4 MDM2 FOS CDKN1A PTEN IKBKB HRAS GRB2 NFKBIE SOS1 FGFR3 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260211%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition SLC2A4 IRS1 TBC1D4 INSR RPS6 MTOR RPS6KB1 MELANOMA%WIKIPATHWAYS_20260211%WP4685%HOMO SAPIENS Melanoma CDKN2A PAK1 BAK1 NRAS BRAF KDR CDK4 AKT3 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC2 PTPN11 MAP2K1 PDE5A MAP2K2 RAF1 HEL114 E2F2 DDB2 PIK3R3 RB1 KIT GADD45B GADD45G CCND1 PIK3CD POLK CALML6 ARAF EXOC7 BAX CALML3 CALML4 PIK3CA ARHA BAD GADD45A PIK3R2 PIK3R1 CALM1 CDK6 E2F3 RHOB NF1 MDM2 GRM3 PREX2 CDKN1A PTEN RAC1 HRAS GRB2 SOS1 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP5293%HOMO SAPIENS Acute myeloid leukemia RELA NRAS BRAF PML CEBPA MYC AKT3 EIF4EBP1 MAPK1 SOS2 KRAS MAPK3 MAP2K1 MAP2K2 FLT3 ZBTB16 RAF1 RPS6KB2 RARA RUNX1T1 RUNX1 SPI1 LEF1 MPO RPS6KB1 NR1C2 CCNA2 PIK3R3 TCF7L2 TCF7L1 KIT STAT5B PER2 CCND1 PIK3CD CHUK STAT3 ARAF IKBKG PIK3CA NFKB1 JUP CSF1R BCL2A1 BAD MTOR PIK3R2 PIK3R1 IL3 PIM1 PIM2 ITGAM CEBPE FCGR1A IKBKB CSF2 HRAS GRB2 SOS1 CD14 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260211%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TEDC1 TEDC2 IFT46 FBF1 KATNB1 IFT70B TUBD1 KIF3B CEP76 MIB1 TUBE1 KIAA0753 CPLANE2 SASS6 CEP162 OFD1 CIBAR1 CEP44 CEP20 DYNC2I2 CEP19 DYNC2H1 DYNLT1 DYNLT2B TRAF3IP1 DYNC2LI1 IFT52 KIF3A TMEM107 BBS9 BBS7 IFT57 RABL2B BBS5 BBS4 IFT140 DNCL1 IFT80 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 IFT172 TMEM216 WDPCP IFT74 CEP104 CEP192 ARL6 ARL3 ARL13B TMEM67 INPP5E EVC2 BBS2 BBS1 SCLT1 IFT81 FUZ TCTN3 TTC8 TCTN2 MKS1 TCTN1 CEP97 IFT27 CC2D2A CLUAP1 ARMC9 IFT25 RPGRIP1L PIBF1 IFT20 CPLANE1 TMEM231 TMEM17 TTC23 C2CD3 B9D1 CBY1 IFT56 RAB23 EFCAB7 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP295 CCDC41 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3286%HOMO SAPIENS Copper homeostasis GSK3B ATP7B SLC31A1 ATP7A APP CASP3 COX17 MT2A SLC31A2 FOXO1 COX11 JUN COMMD1 MT4 MT3 PIK3CA ATOX1 MT1A MTF1 PRNP MT1F SP1 MT1G MT1B XAF1 STEAP1 STEAP2 MT1E HEL-S-44 CCS APC STEAP4 ADAM17 ADAM10 FOXO3A MDM2 STEAP3 PTEN ADAM9 CCND1 SLC11A2 BACE1 SCO1 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260211%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence HMGA1 SLC2A4 MDH2 PARP1 GOT2 ELAVL1 NAMPT CCL27 PRKAA1 RELA SIRT1 SIRT3 IL6 IL1B SIRT5 HEL-S-32 NMNAT2 SIRT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260211%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBG1 HBA2 HBE1 GATA1 HBB HBZ tal-1 HBG2 LDB1 LMO2 HBD RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260211%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer MCM6 TTK CDC45 RRM1 RRM2 TOP2A DHFR WEE1 SUV39H1 HMGB1 CDK4 MYC CDK2 MAPK13 RPA3 SMC2 RPA1 NPAT HLTF PLK4 CCDC6 RAF1 CDKN1B RBBP7 HDAC1 CCND3 TYMS E2F2 PRMT2 POLD3 SMC1A CCNA2 CCNE2 POLE TFDP1 CCNB2 RB1 CCNB1 RBBP4 POLE2 CDC2 CCND1 CDT1 CHEK1 FAF1 CDC25B POLA1 SMC3 MSH6 RFC3 RFC4 BARD1 FANCG SAP30 HMGB2 PCNA PRKDC TFDP2 CDK6 E2F3 MDM2 CCNE1 H2AZ1 RBP1 ZNF655 SKP2 PRIM1 CDKN1A SIN3A MCM7 ORC1L MCM3 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260211%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MMAA MMACHC MMADHC TCN2 MTR CD320 TCN1 CUBN CBLIF OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy COL1A1 COL3A1 RELA STAT3 RUNX2 FGFR4 RELB CTGF CEBPB ACAN VEGFA JUN PIK3CA KDR COL10A1 NFKB1 AKT3 MAPK1 JUND SPP1 MAPK3 VHL SOX9 FOSL2 FOSL1 FGFR2 FGFR1 CNMD P4HTM GANC DDR2 IBSP JUNB FOS NTRK1 PRKCA LAMTOR1 HIF1A NGF COL2A1 FOSB FGF23 FGFR3 GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA5 ST3GAL5 ST3GAL1 NEU3 B4GALNT1 NEU4 HEXB HEXA ST8SIA1 ST8SIA6 SIAT4C B3GALT4 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260211%WP5461%HOMO SAPIENS Primary ovarian insufficiency SOX8 FOXL2 BNC1 NR5A1 WT1 AMH DCAF17 ATG9A CYP17A1 NBN LAMC1 ZAR1 ALOX12 STAG3 SLX4 BLM FANCM FANCL WRN FANCA FANCC HSD17B4 HSD17B1 RFWD3 NUP107 ERAL1 PRDM1 SALL4 ATM BMPR1A FMR1 BMPR2 BRCA2 POLR2C PCCA PCCB STAR BMP6 RAD51 NR3A2 TP63 NOTCH2 AMHR2 LMNA PRORP ANTXR1 EIF2B1 EIF4ENIF1 MEIOSIN POF1B MEIOB SIL1 NANOS3 EIF2B2 PREPL MSH4 NOBOX KHDRBS1 AARS2 EIF2B5 AIRE PPM1B HMMR WDR62 STRA8 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 TGFBR3 HROB LHX8 MCMDC2 MCM9 ELAVL2 BMP15 POLG LARS2 C1orf146 MRPS22 SIX6OS1 HAX1 PSMC3IP RECQL4 CCDC185 MGME1 C10orf2 MND1 GNAS CENPE POLR3H NLRP11 XPNPEP2 SPATA33 MST1R FSHR FIGLA DAZL CLPP GDF9 DMC1 ZP3 PGRMC1 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260211%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence CERS2 PLCB1 RPP38 PRKCB SPHK1 SGMS2 PRKCA CDK4 CDKN1A SGPP1 TERT RB1 UGCG CDK2 MAPK1 S1PR2 SPTLC1 GLB1 S1PR5 S1PR1 DEGS1 MTOR KDSR MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260211%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 H2AX CDKN1A MYC CDKN1B CREB1 CCND3 CCNE1 ATM RAD52 CCND1 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260211%WP2369%HOMO SAPIENS Histone modifications H3C8 EZH2 SET SUV39H2 SUV39H1 SETD2 EHMT1 H3C15 EED KMT2E SETD4 SETD5 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L EZH1 KMT2C SETD7 PRDM2 KMT2A SMYD2 KMT5B SMYD4 SMYD3 H4C7 H4C9 MLL2 SETDB1 HIST1H4L KMT5C SMYD1 SETD1B SETD1A SETDB2 SETMAR AEBP2 H3F3B ASH1L SETBP1 MIRNA BIOGENESIS%WIKIPATHWAYS_20260211%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DGCR8 DICER1 DROSHA RAN TARBP2 BLADDER CANCER%WIKIPATHWAYS_20260211%WP2828%HOMO SAPIENS Bladder cancer MMP9 CDKN2A EGFR TYMP ARAF NRAS BRAF VEGFA SRC THBS1 RASSF1 CDK4 MYC CXCL8 ERBB2 HBEGF MAPK1 KRAS MAP2K1 MAP2K2 PIK3R2 PIK3R1 EGF RAF1 RPS6KA5 MDM2 CDKN1A RB1 MMP2 DAPK2 HRAS UPK3A CCND1 FGFR3 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260211%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN HIF1A VEGFA VEGFB VEGFC HES1 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260211%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX14 COA6 COX1 CSRP2BP PET100 FAM36A COX10 CMC1 TMEM177 PNKD COX17 SMIM20 COX7A2 COX11 COX7B COX4I1 SURF1 COA3 COX6A1 COX8A COX2 COX6B1 COX7C COX3 COXFA4 COX5A COX19 COX16 COX18 TACO1 HIGD1A PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260211%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway HEL70 RDX ARHA SEPTIN2 MYL2 RAB35 KIF23 EZR OCRL EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260211%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects RGS16 PRL KLF2 CXCL12 ERBB4 MYB 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome MEF2C PRL ASCL1 SEPTIN2 MROH2A DGKD HJURP ERFE KLHL30 THAP4 RRAGB ACKR3 RRAGD AGAP1 RAMP1 OR6B3 TRPM8 OR6B2 GAL3ST2 MTERF4 RAB27A COPS9 GBX2 SNED1 NFKBIA RTP5 RNPEPL1 PRH MYOG ING5 FARP2 SEPT6 HEL-S-28 KIF1A ILKAP AQP12B AQP12A AGXT DUSP28 CXCR4 GABARAPL2 ANO7 OTOS RPS6 ITGB3 GYS1 ARL4C USP40 ARF5 ASB18 CENPA CYTH2 SPP2 D2HGDH IRF8 ANKMY1 CYTH1 MLPH CAPN10 RAB17 ASB1 ARF1 HAMP CXCL12 TWIST2 UBE2F CALCRL UGT1A3 RAC1 NEU4 CXCL11 SH3BP4 UGT1A8 EGFR TRAF3 PDX1 PDGFA TNF DISC1 UGT1A10 BOK UGT1A1 UGT1A9 ABCA1 HES1 MAP1LC3A TRAF3IP1 MAP1LC3C EEF1A1 PER2 MYOD1 CALCA DKFZp762B153 DTYMK MAP4 JUN UGT1A4 GABARAPL1 UGT1A7 GABARAP SEPTIN4 HES6 GPC1 PDCD1 CALM1 RRAGA IL13RA1 COPS8 IL1B NEDD8 NDUFA10 PPP1R7 ITPK1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260211%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 ZEB2 HDAC2 ELF3 TGFB1 SUZ12 FOXC2 HDAC1 SIRT1 EZH2 SNAI1 SNAI2 SUV39H1 TCF4 KDM1A PRRX1 TWIST1 KLF8 GSC2 SIX1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260211%WP2878%HOMO SAPIENS PPAR alpha pathway CPT2 KLK15 CYP8B1 PLTP FABP1 ACADM SLC27A1 EHHADH UGT1A9 DBI NR1C1 CDK4 MYC APOA5 RXRA NR1H3 APOC3 CPT1A CYP4A11 CDC2 CYP7A1 CCND1 APOA2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260211%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 CYP2A6 UGT1A10 CYP1A2 SULT2A1 CYP1B1 SULT1A1 SULT1E1 CYP1A1 CYP2E1 UGT1A4 UGT2B15 CYP2C19 CYP3A4 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260211%WP474%HOMO SAPIENS Endochondral ossification MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260211%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase CYP2C8 CYP2J2 COX5A CYP2C9 HEL-S-22 COX8A EPHX2 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260211%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 HEL-S-68p H2AX H3F3B STAT3 KHK HEL-S-30 MYL2 SNAP23 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260211%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GTPBP4 GJB6 ITGB1 CCND2 LAMA5 NCAM1 INHBA RUNX2 PDGFA SNAI1 BMP4 SHH EDAR NFKB1 PDGFRA CTNNB1 MYC LRP5 PTCH1 TP63 SMO FGFR2 FZD1 LEF1 TNLG7C CCND1 FOXI3 ERYTHROPOIESIS%WIKIPATHWAYS_20260211%WP5607%HOMO SAPIENS Erythropoiesis IL3RA TF GDF11 HBB KITLG EPOR EPO TNFSF6 CD79A HBG2 HBD HBG1 HBA2 HBE1 GATA1 FAS GATA2 CD34 PTPRC KIT TFRC HBZ IL3 ANGIOGENESIS%WIKIPATHWAYS_20260211%WP1539%HOMO SAPIENS Angiogenesis MMP9 CREBBP ANGPT1 FGFR2 FLT1 FGF2 VEGFA PLCG1 SRC PIK3CA KDR PDGFRA HIF1A MAPK1 SMAD1 MAPK14 TIMP3 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260211%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome HMGA1 MAPK10 MAPK9 MAPK8 CRP ACLY SLC27A2 PRKAA2 MAPK1 MAPK12 MAPK3 MAPK13 MAPK11 MAPK14 G6PC3 PRKAG1 PRKAG2 ACACA PRKAG3 PRKAA1 G6PC2 PRKAB2 PRKAB1 ACACB G6PC1 PCK2 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260211%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260211%WP4753%HOMO SAPIENS Nucleotide excision repair XPA XPC CUL4A ERCC5 POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 GTF2H5 CUL4B ERCC2 MNAT1 RBX1 RPA3 RPA1 ERCC1 PCNA CETN2 CDK7 POLD3 RFC1 POLD4 DDB2 POLE LIG1 POLE2 POLD2 POLE3 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260211%WP5061%HOMO SAPIENS Fatty acid transporters ACSL5 ACSL3 CD36 FABP1 FABP9 FABP4 FABP5 DBI FABP6 SLC27A4 ACSL1 FABP2 ACSL6 FACL4 GLYCINE METABOLISM%WIKIPATHWAYS_20260211%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL10 TMPRSS2 IL2 IL6 IL7 CXCL8 IL1B TNF ACE2 CCL2 IL2RA CCL3 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260211%WP3298%HOMO SAPIENS Melatonin metabolism and effects GSK3B IRAK1 CAMK2A CSNK1D MAP2 ASMT SULT1A1 TRAF6 FOXO1 NFKB1 CSNK1E CYP2C19 ACHE MAOA ECE1 CALM1 ADRB1 MTNR1A CRY2 MTNR1B CRY1 APOE CYP1A2 CYP1B1 SIRT1 CYP1A1 AANAT EDN1 PRKCA PER2 PER1 PER3 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260211%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary PLCB4 MMP9 PIK3CD PLCB1 PLCB2 STAR NRAS KISS1R KISS1 BMP15 PIK3CA NFKB1 MAPK1 KRAS MAPK3 AMH MAP2K1 MAP2K2 CYP11A1 RAF1 ARRB2 FSHR HSD3B1 PRKCH PRKCB PRKCE PRKCA GDF9 PLCB3 HRAS PRKCQ THERMOGENESIS%WIKIPATHWAYS_20260211%WP4321%HOMO SAPIENS Thermogenesis ADCY3 ADCY1 ADCY8 ADCY6 RPS6KA2 NRAS KDM3A HEL-S-7a KDM1A RPS6KA3 PRKG1 MAP2K3 PRKAA2 SOS2 MAPK12 KRAS MAPK13 MAP3K5 ATF2 RPTOR MAPK11 MAPK14 PRKAG1 MLST8 PRKAG2 SMARCD1 SMARCC1 ACTG1 CREB3L3 SMARCD2 RPS6KB2 PRKAG3 CREB3L4 SMARCC2 PRKAA1 SMARCD3 RPS6KA6 RPS6 LIPE PRKACG ARID1B PRKAB2 RPS6KB1 RHEB CPT1C PRKAB1 AKT1S1 ADCY9 ACSL1 ACSL6 FACL4 CPT2 ACSL5 ACSL3 TSC2 TSC1 ACTL6B SIRT6 SLC25A29 ADRB3 BMP8A BMP8B ACTL6A ZNF516 PLIN1 MGLL KDM3B UCP1 PRDM16 CPT1A GNAS FGF21 MTOR PNPLA2 SLC25A20 GCG SMARCA4 ARID1A PPARG FGFR1 PS1TP5BP1 RPS6KA1 CREB3L2 CREB3 CREB1 FRS2 PPARGC1A CREB5 CNR1 DPF1 HRAS DPF3 GRB2 SMARCE1 SOS1 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy LPIN1 LPIN2 LPIN3 ITGB4 BSCL2 CAVIN1 INS PIK3CA HMFN0839 DGAT1 HIF1A IRS1 FYN GRB2 DGAT2 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4149%HOMO SAPIENS White fat cell differentiation RORA KLF4 CEBPA CEBPB TLE3 EGR2 FOXO1 KLF5 CEBPD INS GATA3 GATA2 EVI1 KLF15 KLF2 DDIT3 NR2F2 CTNNA1 ZNF423 RARA PPARG WNT10B NR3C1 IRF4 TCF7L1 CREB1 NR1H3 STAT5B IRF3 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260211%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma PLCB4 MYL3 ADCY3 ADCY1 PLCB1 ADCY8 PLCB2 ADCY6 MYL1 NR3C1 ADRB2 MYL4 PLCB3 CREB1 ADCY9 PRKAR1B PRKAR1A MYL2 GNAS STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260211%WP4463%HOMO SAPIENS Steroidogenic pathway CYP11A1 STAR HSD3B1 CYP17A1 HSD17B1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260211%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta COL1A1 MBTPS1 PPIB PLOD2 MIA3 LRP5 TMEM38B COLGALT1 MBTPS2 IFITM5 LRP6 CRTAP P3H2 P3H1 COL1A2 PLOD1 ADAMTS2 LOX P4HA1 BMP1 TNFSF11 FZD1 SP7 TNFRSF11B P4HA2 TNFRSF11A WNT1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260211%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides CERS5 CERS1 CERS2 tmp_locus_29 B4GALNT1 B4GALT1 CERS3 CERS6 CERK SGMS1 SPHK1 B3GNT5 SGMS2 A3GALT2 DGAT1 UGT8 UGCG SPTLC1 A4GALT KDSR MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260211%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GSK3B FGFR2 AXIN1 MAP3K1 ROCK1 FRAT1 CTNNB1 FOXL2 MAPK1 ARHA WNT4 SRY MAPK11 GADD45G FGF9 SOX9 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260211%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 HEROIN METABOLISM%WIKIPATHWAYS_20260211%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260211%WP5174%HOMO SAPIENS Ulcerative colitis signaling NOD2 IL2RG TGFB1 HLA-DMA IL10 IL13 NFATC1 GATA3 FOXP3 NFKB1 IL4 IL5 IFNG TNF MAF IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260211%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IF2B1 TLR4 RORC STAT1 STAT3 STAT4 IL12RB1 IL12B TYK2 IFNG IL23A IL17F CSF2 TNF STAT5B IL17A ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA2 MAPKAP1 SHC1 PDPK1 CYP3A4 EIF4EBP1 PRKAA2 SOS2 PTPN1 SHC2 RPTOR SHC3 PRKAG1 MLST8 PRKAG2 SLC2A4 EIF4E RPS6KB2 PRKAG3 CBLC RPS6KA4 RPS6KA6 GYS1 RPS6KA5 PRKAB2 MAP3K8 RPS6KB1 MAP3K6 RHEB MAP3K7 PRKAB1 SREBF2 PIK3R3 G6PC1 MAP3K12 HEL-S-31 FLOT1 FLOT2 MAPK10 CAP1 MAP4K1 MAPK9 TSC2 MAP4K2 MAPK8 MINK1 TSC1 EXOC7 MAP4K3 MAP3K2 HEL-S-42 ABCG8 ABCG5 SCD CYP7A1 PIK3R4 SESN3 PIK3R2 PIK3R1 TRIP10 RAPGEF1 MAP3K13 GSK3A HRAS INSR MAP3K1 FOXO1 INS RPS6KA3 IRS1 MAP2K3 RXRA IRS4 MAP2K4 MAPK1 MAPK12 MAP2K6 MAPK3 MAPK13 MAP3K5 MAPK11 MAP2K1 MAPK14 MAP2K2 MAP3K10 MAP3K11 RAF1 MLXIPL FASN PRKAA1 LPL CYP2B6 ANGPTL8 NR1H3 THRA GSK3B PIK3CD MAP2K5 SLC16A2 CRK SLCO1C1 PIK3CA MAPK7 NR1A2 MAP3K14 MTOR PCK1 FOXO3A PIK3C2G PIK3C2A FBP1 CBL RPS6KA1 MAPK6 MAPK4 RICTOR SOS1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260211%WP4352%HOMO SAPIENS Ciliary landscape MCM5 MCM6 CAMK2A IFT46 CREBBP IFT70B HDAC2 WDR26 RANBP9 RMND5A RAB14 XPNPEP3 MKLN1 GID4 CTBP2 DYNC2I2 NEFL TFAP2B DYNLT1 DYNLT3 DYNLL2 NDUFA5 DYNLT2B RB1 MCM10 MYL6 DYNC1H1 DYNLRB2 EXOSC4 DNCL1 EXOC8 TBC1D4 EXOC7 YAP1 EXOC4 EXOC3 EXOC6 IFT172 MSH2 EXOC5 EXOC2 DOCK5 EXOC1 IFT74 PSMD7 TFAP2C SNAP29 DGKE UBE2D2 MCM2 SMC4 APMAP IFT81 TIPRL ERF ARL8B INTU USH1C CEP97 DDX5 HEL-S-296 IFT27 CDH23 NUP88 IFT25 AAR2 PSMD12 CTSA UBE2H TFAP2D HEL-S-91n TFAP2E PSMD13 RHBDD2 EXOC6B CNOT10 GDI1 LSM4 EHD3 CNOT1 WNK1 LCN2 RANBP10 RAC1 UQCC GLB1 ZMYND19 MYL6B RPGR TMED1 GLA DFNB31 NINL RBM14 PSMC6 NUDC ECHS1 PSMC4 CNOT6L NUP133 EIPR1 RAB3IL1 HEL113 ARFGAP3 RABEP2 CD2BP2 NME8 MAPRE2 CEP170 CCDC40 IFT70A ANKS3 VPS4A RAB21 RQCD1 RMND5B WEE1 DNPEP PGRMC2 VAPB BBIP1 GID8 CTNNB1 NEF3 YPEL5 DCAF7 TFAP2A HDAC1 MFAP1 PAFAH1B1 POM121 EIF5B TRAF3IP1 DVL3 RAB8A IFT52 BBS9 BBS7 IFT57 SNRPB2 BBS5 CEP290 IQGAP3 ACSL3 BBS4 IQCB1 IFT140 IFT80 LZTFL1 IFT43 MCM9 HEL-S-47e CBS NFKB1 EFHC2 STOM DYNC1LI1 APC BBS2 NEK8 BBS1 CALM1 MAEA ARMC8 FUZ TTC8 IQGAP1 MKS1 CLUAP1 COPS7A COPS4 IFT20 COPS6 IFT22 SSNA1 COPS5 COPS8 RALB CDR2 H3F3B NDUFA9 HTRA2 IFT56 MCM7 LRPPRC MCM3 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260211%WP5175%HOMO SAPIENS Disorders in ketone body synthesis OXCT1 ACAT1 HMGCL BDH1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5531%HOMO SAPIENS AKT signaling and ARTD family members GSK3B PIK3CD TSC2 TSC1 MAPKAP1 IKBKG FOXO1 PIK3CA PARP3 AKT3 RPTOR MTOR PIK3R4 PIK3R2 PIK3R1 MLST8 PARP2 PIK3R5 PARP1 PHLPP1 PIK3C2G PIK3C2A SIRT1 PIK3C2B ATM PIK3R3 RICTOR STK11 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260211%WP5093%HOMO SAPIENS Opioid receptor pathways TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260211%WP1471%HOMO SAPIENS Target of rapamycin signaling TSC2 TSC1 PRR5 MAPKAP1 HMGCR RRAGB RRAGD DDIT4L PRKAA2 EIF4EBP1 FKBP1A RPTOR ULK2 MTOR ULK1 PRKAG1 MLST8 PRKAG2 CDC42 PRKAG3 PRKAA1 RRAGA DDIT4 PRKAB2 RPS6KB1 IDI1 RHEB PRKAB1 AKT1S1 PRKCA RAC1 RICTOR EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260211%WP4217%HOMO SAPIENS Ebola virus infection in host TLR4 ITGB1 IRF7 CREBBP EP300 CAV3 NEDD4 VAV2 SOCS3 HLA-B HLA-F HLA-G HLA-E HLA-DRA FLNA VPS11 VPS39 VPS16 AXL IKBKE VPS18 CLEC4M VPS33A ITGB3 ICAM2 RFC1 VPS41 PIK3R3 C1QBP MBL2 ITGA1 ITGA2 SCIN ITGA4 HLA-DRB5 HLA-DMA RAB7A TYRO3 HAVCR2 HLA-A IL4 CLTB CTSL HLA-C ACTN1 ACTN4 PIK3R2 PIK3R1 EIF2AK2 RAC1 MERTK IRF3 HLA-DQA2 HLA-DQA1 EGFR PAK1 RELA STAT1 VPS4A IGF1R HLA-DRB1 MFGE8 CLEC10A ICAM3 MAPK1 HLA-DOA HLA-DOB MAPK3 KPNA1 BST2 CD300A TFAP2A TIMD4 TSG101 CLEC6A RAB5A ASGR1 CD209 HAVCR1 ADAM17 HLA-DPA1 HLA-DQB2 RAB9A HLA-DQB1 ACTG1 HLA-DMB DAB2IP HLA-DPB1 FOLR1 NFKB2 NPC1 REL TIAM1 EIF2S1 RASA2 PIK3CD RELB TBK1 PIK3CA NFKB1 CAV2 ARHA RIGI CLTC CDC42 FLNB CLTA PRKRA IQGAP1 RHOB PS1TP5BP1 ITGAV CLTCL1 ITGA6 NPC2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260211%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MAPK8 STAT3 MYEF2 JUN PRKCB EDN1 PRKCE FOS MAP2K3 GATA4 PPP3CA MAPK1 ARHA RAC1 CTF1 CAMK2D MAPK11 MAPK14 NFATC4 IL6ST FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260211%WP143%HOMO SAPIENS Fatty acid beta oxidation ECHS1 CPT2 ACSL5 ACSL3 ACAT1 ACADM DLD HEL-S-49 CPT1A ACADVL LIPC ACADL PNPLA2 SLC25A20 ACADS CHKB HADHB LPL GCDH LIPF LIPE CRAT ACSS2 GPD2 DECR1 ACSL1 ACSL6 FACL4 GASTRIN SIGNALING%WIKIPATHWAYS_20260211%WP4659%HOMO SAPIENS Gastrin signaling MEF2C MEF2B ITGB1 CDKN2A KLF4 MEF2D SRC LAMTOR3 SHC1 EIF4EBP1 HDAC7 FYN PTPN11 NFKBIA RHOD ELAVL1 CDKN1B RPS6 RPS6KB1 PXN TCF4 PIK3R3 CCND1 CD44 MAPK9 MAPK8 STAT3 KAT5 IL2 CXCL8 PIK3R2 PIK3R1 MMP7 TJP1 IKBKB RAC1 EGR1 HRAS SERPINB2 BIRC5 EGFR PAK1 PTGS2 RELA SLC9A3 VEGFA FOXO1 CTNNB1 CLDN1 MYC IRS1 MAPK1 KRAS MAPK3 ATF2 MAP2K1 MAPK14 MAP3K11 BCL2L1 RAF1 ARHGEF28 GAS PRKCH TFF2 PRKCE PRKCA KIT PRKD2 PRKCQ PRKD1 BMP2 GSK3B CASP3 CHUK CRK PLCG1 BIRC2 ROCK1 BIRC3 JUN PIK3CA NFKB1 SP1 ARHA HDC BAD MTOR CDC42 ANXA2 YES1 CCKBR ARRB2 PPARG FOXO3A RHOB FOS CDKN1A CREB1 GRB2 SOS1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260211%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC5 DNAJB1 CRTC2 CREB1 SIK1 HDAC7 GNAS SIK3 SIK2 MACROPHAGE MARKERS%WIKIPATHWAYS_20260211%WP4146%HOMO SAPIENS Macrophage markers CD74 CD83 CD68 LYZ CD163 F3 CD14 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer GSK3B RB1CC1 TSC2 MAPKAP1 TFEB NRAS FOXO1 PIK3CA EIF4EBP1 KRAS BAD RPTOR MTOR ULK1 PIK3R2 PIK3R1 MLST8 CDKN1B FOXO4 FOXO3A GRB10 RHEB PIK3R3 PTEN RICTOR HRAS GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260211%WP2596%HOMO SAPIENS Gastric acid production CCK VIP SCT PGA3 PGC PGA5 MUC6 GAS CBLIF MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260211%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway PIK3CD PLCG2 NCKAP1L VAV1 VAV2 TREM2 PIK3CA TREM1 LAT LYN PIK3R2 SYK PTPN6 PIK3R1 CYBB ITGAM NCF2 C1QB C1QA PIK3C2A RAC3 NCF1 NCF4 FCER1G VAV3 PIK3R3 FCGR1A CYBA RAC1 ARPC1B SIGLEC7 TYROBP C1QC MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260211%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PRKAA1 PTBP1 SIX4 STK11 CTDSP1 STRADB GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260211%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P PFKP HEL-S-30 PPM2C 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1CC1 GABARAPL2 TRAF2 ATG16L1 ATG101 GABARAPL1 GABARAP RB1 TNF PTK2B MAP3K5 ULK1 WDR45B TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260211%WP5130%HOMO SAPIENS Th17 cell differentiation pathway NR1D1 SMAD2 STAT1 TGFBR1 ZAP70 TYK2 GATA3 IL27 SOCS3 RXRA MAPK1 LAT MAPK14 NFKBIA CRY1 RARA RUNX1 IRF4 NFIL3 IL6R IFNG HIF1A IL23A IL17F AHR PRKCQ LCK PER1 IL17A IL27RA IL2RA IF2B1 IL23R RORC RORA MAPK8 CD3G IL-21 TGFB1 CD3E HLA-DMA STAT3 CD3D TBX21 IL21R PLCG1 IFNGR1 JUN NFATC1 FOXP3 NFKB1 IL2 IL4 IL6 MTOR FOS IKBKB PPP3CA IL1B JAK1 VISUAL CYCLE%WIKIPATHWAYS_20260211%WP5534%HOMO SAPIENS Visual cycle RBP3 RDH11 RDH8 RHO RBP1 RDH5 OPN1LW RLBP1 RPE65 RDH10 OPN1MW RDH12 OPN1SW LRAT ABCA4 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260211%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260211%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCB4 PI4K2B PIK3CD PLCD3 TPTE2 PLCB1 PLCD4 IPMK PLCB2 FIG4 PI4KB PIP4K2A PLCG2 PLCG1 PIK3CA INPP5D PI4K2A INPP5E PLCE1 PIK3C2G PIK3C2A PIK3C2B MTMR1 MTMR2 MTMR8 INPP4A STM7 INPP4B PTEN MTMR6 MTM1 PLCB3 PIP4P2 PIP4P1 PIP5K1A PIP4K2B PIP5K1C SACM1L OCRL PIKFYVE MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260211%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 FST FGFR2 RBFOX2 CBX2 SOX8 EMX2 AMHR2 CTNNB1 DMRT1 DHH FOXL2 GATA4 NR5A1 INSL3 WT1 WNT4 SRY MAPK11 RSPO1 AMH FGF9 SOX9 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260211%WP4318%HOMO SAPIENS Mitochondrial fission and fusion BCL2L1 FIS1 MIB1 OPA1 BAX MTFP1 MFN2 BNIP3 MFN1 SH3GL2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260211%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ENO1 PFKM HEL-S-68p PGAM2 HEL-S-133P GPT HEL-S-49 HEL-S-30 HEL-S-87p HEL-S-162eP FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders SLC34A3 ORAI1 KL DMP1 CYP24A1 FGFR2 ALPL FAM20C SLC34A1 ROS1 GALNT3 PTH ENPP1 NFKB1 CDKN1A NFKB2 CYP27B1 SPP1 CCND1 CYP11B2 FGF23 FGFR3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260211%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260211%WP3929%HOMO SAPIENS Chemokine signaling ADCY3 ADCY1 ADCY8 ADCY6 STAT2 GNG3 GNG2 GNG5 CCR2 GNG4 GNG7 VAV1 GNG8 VAV2 CCL11 SHC1 c-fgr CX3CL1 CCL5 CCL19 CCL7 SOS2 CCL28 SHC4 SHC2 CCL4 SHC3 NFKBIA CCL1 NFKBIB CCL15 CXCR4 CXCR6 PRKACG PXN PIK3R3 STAT5B PTK2B CCR10 JAK3 CCR1 XCR1 GNAI1 CXCL12 STAT3 WAS CCR8 GNAI3 CCR4 RAP1A CRKL CCR3 LYN PIK3R2 PIK3R1 IKBKB RAC1 HRAS CXCL13 CXCL11 CXCL14 CCR6 PLCB4 PLCB1 PLCB2 PAK1 RELA STAT1 BRAF NRAS ADRBK1 PPBP CX3CR1 CXCL3 AKT3 MAPK1 KRAS XCL1 MAPK3 MAP2K1 CCL17 CCL20 CCL25 CCL24 CCL22 RAF1 CCL21 CCL27 PF4 CCL26 NCF1 PRKCB GNG10 CCR7 CXCR5 GNGT2 ADCY9 TIAM1 PARD3 GSK3B PIK3CD PRKCZ GRK5 CHUK GRK4 WASL PREX1 CRK ELMO1 IKBKG ROCK1 GRK1 ROCK2 DOCK2 GNG12 PRKX GNG11 PIK3CA NFKB1 GNG13 GNB2 GNB1 ITK GNB4 CXCL5 GNB3 GNB5 CDC42 PIK3R5 ARRB2 FOXO3A GNGT1 CXCL16 VAV3 IL8RB PLCB3 CXCL9 CXCR3 CSK GRB2 SOS1 CCL3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP5 NIPA1 TUBGCP6 TUBGCP4 NIPA2 CYFIP1 FMR1 NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260211%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP9 EGFR SMAD2 COL1A1 SMAD4 FLT1 RELA TGFBR3 RELB CHD2 CTGF SNAI1 VEGFA SNAI2 TGFBR1 NRP1 SRC KDR NFKB1 PLXNA2 HGF AKT3 PLXNA1 PLXNA4 CDK2 MAPK1 MAPK3 MET COL1A2 MAP2K1 MAP2K2 SEMA3A EGF CDKN1B CCNE1 GSK3A CCNE2 PECAM1 NFKB2 MMP2 RAC1 REL TGFBR2 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer CDKN2A DOCK1 HGF EIF4EBP1 RPTOR PTPN11 CDKN1B HSD3B1 HSD17B3 ETV4 HSD17B7 CYP17A1 RHEB PXN RB1 PTK2B CDC2 CCND1 CHEK2 CHEK1 MAP4K1 TSC2 MAPK8 TSC1 STAT3 BAX CDC25B MSH6 MSH2 BLM ACTL6A CPN1 RAP1A KLK3 BARD1 CASP8 CRKL HSD17B4 HSD17B1 HSD3B2 PLK1 RAPGEF1 SMARCA4 ARID1A F13B NOXA1 MDM2 ATM ATR PTEN BRCA1 JAK1 HRAS ERG SMAD2 PAK1 STAT1 MRE11A RAD50 CDK4 MYC CDK2 MAPK1 MAPK3 ATF1 MAP2K1 MAPK14 MAP2K2 FOXA1 BCL2 SMARCD1 SMARCC1 RAF1 SMARCD2 SMARCC2 SMARCD3 ARID1B FKBP5 HSD17B2 CDKN2B SPRY2 CASP9 CASP3 ACTL6B CRK EIF4E1B JUN PIK3CA SP1 SPRY1 SPINK1 BAD MTOR PRKDC FOS CDKN1A RICTOR GRB2 SOS1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260211%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis LDLR FASN PRKAA1 SIRT1 HMGCR ABCA1 SIRT6 SREBF2 HMGCS1 NR1C1 NR1H3 PPARGC1A MED15 SCD MTOR SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260211%WP4496%HOMO SAPIENS Signal transduction through IL1R IRAK1 IRAK2 MAPK8 MYD88 TGFB1 RELA CHUK TRAF6 MAP3K1 MAP3K7IP1 JUN NFKB1 IL6 MAP2K3 TNF MAP3K14 MAP2K6 MAPK14 NFKBIA IRAK3 ECSIT MAP3K7 IFNB1 IL1R1 IKBKB IL1B IL1RN IFNA1 IL1A FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260211%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR5 CCR6 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260211%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260211%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies ITGA4 ITGB1 S1PR3 S1PR4 S1PR5 HEL-S-171mP MS4A1 S1PR1 BTK EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260211%WP410%HOMO SAPIENS Exercise induced circadian regulation CBX3 NR1D2 G0S2 PSMA4 KLF9 HLA-DMA HEL-S-22 CEBPB PPP1R3C DAZAP2 BTG1 TOB1 STBD1 CLDN5 SUMO3 ERC2 RBPMS CRY2 ZFR ETV6 AAG1 CRY1 HEL-S-72p MYF6 SUMO1 UCP3 IDI1 NCKAP1 GSTM3 PIGF PURA QK3 PER2 H2BC15 PER1 VAPA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260211%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TOMM70 IKBKE IFNB1 MAVS TRAF3 RIGI TRAF6 TBK1 IRF3 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260211%WP5390%HOMO SAPIENS Pancreatic cancer subtypes CDH17 SCEL PLA2G10 SPRR1B TSPAN8 FAM83A CYP3A7 DHRS9 TNS4 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 KRT20 LGALS4 VSIG2 S100A2 AGR2 AGR3 TFF2 CST6 FAM3D REG4 KRT6C SERPINB3 BTNL8 KRT7 GPR87 ANXA10 LYZ LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 AREG KRT6A FGFBP1 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260211%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IRAK1 NLRP3 MMP9 PLA2G7 MYD88 HEL-S-134P TLR1 PIK3CA FCER1A NFKB1 F2 S100A9 IL18 IL1R1 IFNG HBEGF IL1B CCL2 F2R CCR3 TIMP1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome PPP4R2 PPP4R4 PARP4 HEL-S-69 ASPHD1 TCP1 KCTD13 ZG16 INO80E MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 MAP2K3 MAPK3 MAP2K6 TBX6 CCDC6 PPP2R1A PAXIP1 KMT2C NR3C1 PAGR1 SMEK1 REL PPP2CA EZR SPN PRRT2 PPP4R3B TRAF2 TRAF6 NFKB1 CASP8 BPTF HEL-S-87p PCNA CCT7 TAOK2 PPARG MLL2 HEL70 PPP2R5D PTEN UNC13B UNC13A HEL-S-90n CCT6B HDAC3 SIAH1 DOC2A FAM57B FIMP CDIPT PPP4R1 CREATINE PATHWAY%WIKIPATHWAYS_20260211%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-29 HEL-S-20 NRF2 ARE REGULATION%WIKIPATHWAYS_20260211%WP4357%HOMO SAPIENS NRF2 ARE regulation GSK3B YES1 NFE2L2 MAPK8 INSR NQO1 CEBPB EPHB2 SRC PIK3CA SLC7A11 HMOX1 PRKCA RBX1 PGAM5 FYN MAF GCLM AIMP2 KEAP1 GCLC CANCER PATHWAYS%WIKIPATHWAYS_20260211%WP5434%HOMO SAPIENS Cancer pathways CAMK2A ADCY3 CDKN2A ADCY1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CAMK2G PDGFRA HGF SOS2 MET TGFA BCL2L11 EGF RPS6KB2 TPM3 FGFR2 NR1C2 PIK3R3 SUFU HIF1A PTCH2 KIF7 STAT5B IL2RG CXCL12 CALML6 ARAF CALML3 FZD10 STAT4 CALML4 IL12RB1 FRAT1 FRAT2 IFNGR1 IL13 EVI1 IL2 IL4 IL5 CXCL8 IL5RA KLK3 CSF2RB CRKL PIK3R2 PIK3R1 IL3 IL3RA EDNRB MGST1 FADD GSTT2 FZD1 WNT10B WNT10A NQO1 FZD3 TXNRD2 FZD2 FZD5 FZD7 FZD9 FZD8 GNA13 IKBKB HRAS APC2 PLCB4 IFNA13 IFNA14 PLCB1 IFNA16 PLCB2 IFNA17 IFNA10 PTGS2 RELA IFNA21 FGFR4 IF1AA9 NRAS BMP4 SHH WNT7B WNT7A FAS CTNNB1 IFNA8 IL7 BDKRB2 MAP2K1 MAP2K2 WNT5B GSTM2 RAF1 TNFSF6 DVL1 DVL2 DVL3 WNT1 WNT3 WNT4 WNT3A RET CYCS GSK3B WNT2B PIK3CD CASP9 CASP3 CHUK APAF1 AXIN1 TRAF2 TRAF6 CRK ROCK1 ROCK2 AXIN2 WNT16 PIK3CA LRP5 ARHA LRP6 NOS2 BAD MTOR APC CDK6 JAG2 E2F3 FZD4 PPARG FGFR1 GLI3 HEY2 CBL WNT9B WNT9A WNT8A WNT8B DLL3 DLL4 PTGER4 IFNA1 GRB2 PTGER2 SOS1 GSTT2B FGFR3 CCND2 TFG EML4 NKX3-1 PLEKHG5 IL15RA ARHGEF11 CDKN1B BBC3 SPI1 IGF2 CCND3 IL12B DDB2 IL12A IL6R CCNE2 IFNG IL23A PMAIP1 GADD45B GADD45G ARHGEF12 PTGER1 PTGER3 GNAI1 BAX PTCH1 SMO SMAD2 SMAD4 RXRA BCL2 NFE2L2 HDAC1 GNA11 NTRK1 ARNT2 EGLN1 EGLN3 RASGRP4 EGLN2 CDKN2B ELOC HMOX1 EDNRA F2R RALBP1 CTBP1 PLD2 SKP2 ARHGEF1 RALB APPL1 CREBBP HDAC2 EP300 CEBPA CTBP2 FLT3 ZBTB16 RARA RUNX1T1 PRKACG RPS6KB1 CCNA2 RB1 JAK3 CCND1 IL2RA IL2RB IL15 MSH6 MSH2 MAX RASGRP3 TPR VHL GADD45A F2RL3 MDM2 MGST3 MGST2 GSTM3 PTEN BRCA2 GSTM5 MMP2 RAC1 MMP3 JAK1 TGFBR2 NCOA1 RALA EGFR FLT3LG BAK1 STAT1 PML DCC MSH3 VEGFA RAD51 HEL-S-125m BCL2L1 GSTA5 GSTA4 KPG_010 RUNX1 GSTA3 LPAR2 LPAR3 LPAR4 GNG10 IFNA7 F2 GNGT2 NFKB2 KIT VEGFB VEGFC HHIP VEGFD POLK KITLG HEL-S-22 CSF3R EPO IFNAR2 BIRC2 COL4A2 BIRC3 COL4A1 COL4A4 COL4A6 IFNAR1 CSF1R TXNRD3 IL7R HSP90AB1 FLT4 LAMC2 ITGAV CDKN1A ITGA6 LAMA1 LAMA4 LAMA3 ITGB1 LAMB3 LAMB2 STAT2 EPOR ALK ERBB2 NFKBIA CTNNA1 CTNNA3 CTNNA2 CXCR4 RPS6KA5 ITGA2B RAC3 E2F2 IFNA6 IFNGR2 LAMC1 FH CKS1B ITGA2 TRAF1 TRAF4 COL4A3 TRAF5 RARB COL4A5 BIRC7 MAPK10 RXRB RXRG LAMA5 MAPK9 MAPK8 LAMB4 TGFB1 STAT3 CCDC42 GNAI3 JUP CASP8 BDKRB1 LAMB1 KNG1 CCNE1 EDN1 BIRC5 CSF2RA TRAF3 PDGFA GSTM1 BRAF IGF1 TGFBR1 FOXO1 IGF1R RASSF1 CDK4 MYC AKT3 CDK2 MAPK1 KRAS MAPK3 NR3A2 AGTR1 IL6ST NOTCH2 NOTCH3 CCDC6 NOTCH1 LEF1 PRKCB HES1 HES5 PRKCA TCF7L2 TERT TCF7L1 ADCY9 GSTM4 BMP2 KEAP1 LPAR1 PLCG2 PLCG1 IKBKG JUN SKP1 PAX8 GNG12 GNG11 NFKB1 GNG13 RBX1 IL6 SP1 GNB2 GNB1 IFNA2 GNAS GNB4 BCR GNB3 GNB5 PIM1 PIM2 GNGT1 HEL-S-21 FOS IL13RA1 PLCB3 DAPK2 CAMK2D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260211%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis SLC2A4 LEP LPIN1 MAPK8 PPARG INSR NR3C1 CEBPA CEBPB FOXO1 CEBPD IL6 IRS1 RXRA CREB1 TWIST1 PPARGC1A TNF PCK2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260211%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 CREB3L3 CREB3L4 RELA RELB IL10 CREB3L2 NFKB1 CREB3 NFKB2 IL6 CREB1 IL1B MAPK12 REL CREB5 MAPK13 CCL2 MAPK11 MAPK14 CD14 ATF4 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260211%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CDC45 MRE11A PML FOXM1 SMARCAL1 RAD50 RAD51 CDK2 DCLRE1A RPA1 UBE2D3 HUS1 FANCD2 HERC2 TOPBP1 CLK2 RECQL EEF1E1 CLSPN TDP1 H2AX SMARCC2 FEN1 NBN SMC1A RNF8 CEP164 ATRIP SHFM1 CDC2 RAD52 CHEK2 RAD17 RAD1 CHEK1 RAD9A XPA PPM1D RBBP8 BCL6 MDC1 IKBKG TRIM28 MSH2 BRIP1 TP53BP1 MCPH1 RECQL4 WRN SP1 FANCA BARD1 UIMC1 PALB2 RFWD3 PLK1 PCNA PRKDC MCM2 PARP1 ABRAXAS1 BRCC3 MDM2 ATM ATR BRCA1 POLN BRCA2 RMI1 USP1 TOP3A XRCC5 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260211%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders CPT2 ACADS ACSL3 SLC22A5 ACADM HADHB PECR EHHADH CPT1A ACADVL ACSL1 ACSF2 ACADL FACL4 SLC25A20 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP11A1 SRD5A2 CYP21A2 AKR1D1 AKR1C1 HSD3B1 CYP17A1 HSD3B2 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260211%WP5087%HOMO SAPIENS Pleural mesothelioma CDKN2A EZH2 KIF23 KDR PDGFRA HGF CTBP2 PRKAA2 MET RPTOR CCL4 TGFA DEPTOR PRKAG1 MLST8 PDGFC PRKAG2 FLT3 EIF4B EGF WIF1 RPS6KB2 PRKAG3 FGFR2 RPS6 PRKAB2 RPS6KB1 RHEB PRKAB1 AKT1S1 HIF1A LIMD1 MCL1 CCND1 TNNT1 ITGA4 NF2 TSC2 TSC1 CXCL12 YAP1 FABP4 FZD10 ROR2 FRAT1 FRAT2 IL10 CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E MAX DKK1 DKK2 DKK4 SFRP4 DDIT3 BARD1 CSNK2B STK38L TNIK ULK2 ULK1 FOSL1 FZD1 CDK7 WNT10B WNT10A FZD3 MDM2 ATM FZD2 FZD5 FZD7 FZD9 UHRF1 FZD8 PTEN BRCA1 LATS1 TEAD4 MMP2 LATS2 MMP3 JAK1 HRAS TEAD2 TEAD3 MMP14 PLCB4 EGFR NTF4 FLT3LG PAK1 BAK1 STAT1 FGFR4 MAP3K1 VEGFA CSNK1A1 WNT7B SFRP1 SLC7A5 WNT7A CTNNB1 FGF10 HMGB1 RPS6KA3 CSF1 HBEGF MAP2K3 MAP2K4 CHD8 MAP2K6 MAP3K5 MAP2K1 MAPK14 MAP2K2 MAP3K10 WNT5B MAP3K11 RAF1 KMT2C EPHA2 AGER ASXL1 WDR5 BAP1 DVL1 FGF8A DVL2 DVL3 KIT WNT1 WNT3 WNT4 RBBP4 FGF6B WNT3A VEGFB MAPKAPK2 CYCS VEGFC MCU VEGFD GSK3B WNT2B PIK3CD WWC1 MAP2K5 NGFR SOX17 KITLG RB1CC1 CER1 CSF3 AXIN1 TRAF2 COL4A2 COL4A1 WNT16 COL4A4 COL4A6 PIK3CA MAPK7 CSF1R NTRK2 LRP5 EFNA5 EFNA4 LRP6 FGF20 FGF22 FGF7 FGF21 CXCL5 FGF8 EFNA1 MTOR FGF9 APC EFNA3 FGF14 CSNK1A1L EFNA2 FGF13 FGF18 FGF12 FGFR1 ITGB4 FLT4 LAMC2 AMOT FGF2 FGF7B ITGAV FGF7A RASSF7 CDKN1A NGF ITGA6 FGF5C LAMA1 LAMA4 LAMA3 GRB2 CXCL1 AREG SOS1 FGFR3 NLRP3 ANGPT4 IDO1 MMP9 ANGPT2 ITGB1 LAMB3 CCND2 ANGPT1 LAMB2 MEF2D BDNF SRC SHC1 SETD2 CCL5 EIF4EBP1 CCL2 MOB1A CTNNA1 CTNNA3 CTNNA2 RASSF2 RASSF3 RASSF4 BBC3 RASSF6 ITGB3 RPS6KA5 HCFC1 IGF2 PHC1 CCND3 PRSS23 IL34 MAD2L1 MAP3K6 DSC3 LAMC1 BAG2 MDK RNF2 CTHRC1 MOBKL1A ITGA1 PAK6 CDH9 CDH8 PAK4 CDH4 ITGA2 CDH10 COL4A3 CDH11 CDH12 HEL-S-31 CDH15 AJUBA COL4A5 CDH17 VGLL4 ACTA2 CIT CD44 MAPK10 CDH19 MAP4K1 CDH24 LAMA5 MAPK9 WWTR1 MAP4K2 MAPK8 SPARC MINK1 TGFB1 LIN28B BAX MAP4K3 CTGF MAP3K2 EED LAMB1 SELE TTI1 MDM4 LGALS9 SUZ12 HMGN1 CCNE1 PPARGC1A CSF2 BMI1 FGF23 FLT1 PRB1 INSR PRB2 CDH6 PDGFA CDH2 IGF1 CD47 OGT FOXM1 CDH16 FOXO1 IGF1R INS RASSF1 CDK4 MYC AKT3 CDK2 YY1 MAPK1 RYK MAPK3 ROR1 ATF2 PDGFD BCL2 ACTG1 EIF4G1 PRKAA1 SOST LEF1 NTRK1 TCF7L2 TERT NTF3 TCF7L1 PIGF KREMEN1 SENP2 SFRP5 ATF3 CXXC4 PORCN NOTUM SLC3A2 BTRC JUN NFKB1 IL6 SP1 SETD5 CTBP1 PS1TP5BP1 HEL-S-1 RPS6KA1 BTC GABPA SETDB1 CDH18 MAD1L1 ACTA1 CREB1 IL1B ACTG2 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP75%HOMO SAPIENS Toll like receptor signaling TLR4 IFNA13 IFNA14 IRF7 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 TRAF3 LY96 IFNA21 IF1AA9 TIRAP MAP3K7IP1 IFNA8 AKT3 MAP2K3 CCL5 MAP2K4 MAPK1 TNF MAPK12 MAPK3 MAP2K6 MAPK13 CCL4 MAPK11 MAP2K1 MAPK14 NFKBIA MAP2K2 NFKBIB IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B IFNA7 MAP3K7 RIPK1 IL12A TICAM1 IRAK1 IRAK4 MAPK10 MAPK9 TAB3 MAPK8 MYD88 CHUK LBP TRAF6 TBK1 IFNAR2 IKBKG JUN IFNAR1 NFKB1 IL6 TLR5 CXCL8 CASP8 SPP1 IFNA2 TLR9 TLR7 FADD FOS IFNB1 IKBKB IL1B RAC1 CXCL9 IFNA1 CXCL11 IRF3 TLR8 CD14 TLR3 CCL3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2 EPHX2 KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260211%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway KIR2DL1 KIR2DL3 VAV1 PLCG1 PRKCA LCP2 IFNG CD34 CSF2 HLA-C TNF RAC1 FYN HRAS LAT TYROBP PRKCQ GRB2 SYK PTPN6 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260211%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX H2AB1 H3C8 SUZ12 BCL6 H2AZ1 EZH2 H2AZ2 RNF2 H3C15 H2AB3 PCGF1 H3F3B MAPK1 H2AJ MAPK3 EED MACROH2A1 BCOR MACROH2A2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260211%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders SLC52A2 ETFDH COQ6 COQ2 SLC52A1 PDSS1 ETFA COQ8A FLAD1 COQ9 APTX COQ7 ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260211%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 SUOX NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260211%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260211%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMB3 LAMA5 LAMB2 SRC SHC1 IRS1 EIF4EBP1 MAPK1 ARHA MAPK3 PTPN11 MAPK14 MTOR PIK3R2 PIK3R1 LAMB1 ITGB4 LAMC2 LAMC1 PRKCA ITGA6 RAC1 LAMA1 HRAS LAMA3 GRB2 SOS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260211%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection HEL-68 HCLS1 TLR4 KRT18 TUBA2 ITGB1 ARPC2 ARPC3 TUBA8 LY96 WASL ROCK1 WAS ROCK2 TUBB8 TUBA1C CTNNB1 CLDN1 TUBB6 TUBA1B TLR5 TUBA1A ARHA FYN TUBB1 ARHGEF2 CDC42 TUBB ACTG1 TUBA4A YWHAQ TUBB2A PS1TP5BP1 NCL NCK2 TUBAL3 NCK1 YWHAZ PRKCA TUBA3E ARPC5 ARPC1B TUBB4B EZR CD14 TUBB4A ARPC4 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX MOCS2 MTARC2 MOCS1 XDH GPHN AOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260211%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260211%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds GSK3B FZD1 MBOAT1 DKK3 LEF1 AXIN1 CSNK1A1 FZD7 FZD8 TCF4 CTNNB1 DVL2 SFRP4 WNT1 TNKS APC CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260211%WP536%HOMO SAPIENS Calcium regulation in cardiac cells RGS16 CAMK2A ADCY3 ADCY1 CACNB1 ADCY8 ADCY6 GNG3 GNG2 GNG5 GNG4 GNG7 RGS20 GNG8 CAMK2G RGS10 CASQ1 RGS11 FKBP1A GJB1 ADRA1B ADRA1A GNAZ GJB6 GNAI1 GJA9 ATP1B3 STIM2 GJC1 GJB4 GJB3 GNAI3 ANXA6 GJD2 HEL-S-99n CASQ2 ATP1A4 PLN KCNJ3 KCNB1 CXNA GNAO1 ADRB1 ATP1B2 ATP1B1 CAMK1 FXYD2 CHRM1 ATP2B3 ATP2B2 ATP2B1 HEL2 GJB2 ORAI1 SLC8A1 RGS4 RGS5 RGS2 GJA1 RGS1 CACNA1C RGS6 RGS7 PRKCH PRKCB GNA11 PRKCE PRKCA CACNB3 CACNA1S ADCY9 PRKAR1B PRKAR1A PRKCQ PRKD1 ITPR2 PRKCZ CHRM2 CHRM3 GRK5 GRK4 ADRA1D SFN ADRB3 GNG12 GJA3 GNG11 GJA5 GNG13 GJA8 PKIB CXNO PKIA GNB2 GNB1 GNAS GNB4 GNB3 GNB5 PKIG CALM1 CACNA1B RYR1 RYR2 ATP2A2 CACNA1A ARRB2 RYR3 GNGT1 KCNJ5 YWHAQ HEL-S-1 YWHAG CHRM4 CHRM5 GJA4 YWHAZ ADRB2 PLCB3 RGS18 RGS17 CAMK2D RGS14 CAMK4 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260211%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling EGFR CREBBP AGTR2 CSF2RA F2RL2 MAPKAP1 IL10RA SRC TYK2 PDGFRA SOCS3 MAPK1 PTPRC IL11RA MAPK12 MAPK3 MAPK13 CTF1 RPTOR GHR IL15RA MAPK11 MAPK14 DEPTOR AGTR1 IL6ST MLST8 IL10RB IFNGR2 PRKCB IFNLR1 AKT1S1 IL6R OSMR JAK3 IL20RA IL20RB IL27RA IL2RA IL2RB MAPK10 MAPK9 IL2RG MAPK8 STAT3 CSF3R IFNAR2 IL21R CNTFR TRIM28 IFNGR1 IFNAR1 MAPK7 PTPRT IL5RA MPL CSF2RB MAPK15 IL22RA1 F2R MTOR IL9R IL3RA IL7R SETD7 F2RL3 DUSP2 MAPK6 MAPK4 JAK1 RICTOR DOPAMINE METABOLISM%WIKIPATHWAYS_20260211%WP2436%HOMO SAPIENS Dopamine metabolism DDC NQO1 MAOA PRKACG PPP2CA TH HEL-S-44 TYR HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC5 CD44 CASP9 SMAD4 MAPK8 PTGS2 CASP3 TGFB1 STAT3 MYOF RRM2 VEGFA COL4A2 TGFBR1 VAV2 BIRC3 JUN NFKB1 FRZB MYC IL6 CXCL8 MAPK3 NOS2 PTPN11 MAPK14 BCL2L1 HNF1A LEF1 TNFSF6 E2F2 HEL-117 IL6R CDKN1A BRCA1 HIF1A CXCR1 RAC1 JAK1 GRB2 CCND1 SOS1 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260211%WP5355%HOMO SAPIENS Metabolic epileptic disorders ECHS1 ACAT1 PSAT1 PSPH ENO1 HEL-S-68p GLDC AMT HEL-S-30 PHGDH HEL-S-20 SLC2A4 ETHE1 SQOR SUOX SPCS1 CDO1 GCDH HEL-S-51e LDHB MPC1 HEL-S-133P GPT HK3 DHTKD1 G6PC1 HEL-S-32 GCK SLC25A15 ASL MOCS2 MOCS1 SFXN1 GPHN ARG1 HEL-S-162eP CBS PFKL SLC25A1 ENO2 PFKM ENO3 SLC25A5 MPC2 PGAM2 ALDH7A1 DLD FBP2 PGAM1 PFKP HEL-S-49 HEL-S-87p CTH MOCS3 HK2 AASS SLC7A2 HEL60 PCK1 PDHA1 MDH2 GOT2 PKLR ASS1 XDH GLUD1 ALDOB SHMT1 FBP1 PC SLC2A3 BTD HLCS SLC2A2 OTC GLS2 AADAT DLAT MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260211%WP2003%HOMO SAPIENS miR targeted genes in leukocytes AP3D1 ARHG ARCN1 WDR11 CEBPB PPIB LAMTOR3 PLXND1 TUSC2 ARID4B HEL-S-30 VPS39 FADS1 TNLG5A TPM3 GYS1 RAB34 MAP3K8 ANAPC1 TMED10 RAB5C ADIPOR2 SLC1A4 CORO1C SAC3D1 MCL1 MPDU1 CD164 SNAP23 BRPF3 HMGA1 CAP1 TBCA IGF2R BCL6 MENT SLC25A1 ADPGK THBS1 TNFAIP2 ADAR LMNB2 TUBA1A TMEM109 ACP2 PRSS21 SCYL1 TXN2 RFT1 DDX5 UNC93B1 GNA13 DNAJB1 POLR2C SPTLC1 ATP6V1F CDIPT ATP6V0E1 POLE4 FMNL2 SERPINE2 CTNNB1 DCAF7 PNP CHORDC1 MAPK14 GOLGA7 CDK5RAP3 BCL2 PPIF IFRD1 LPL PISD MTHFD2 TYMS RTN4 POM121 MRPL20 SLC7A11 RDH10 KCNN4 SNX6 PHC2 SFXN1 HEL-S-26 HEL-S-47e ARF4 TRAM1 HMOX1 MRC2 TMEM43 TMED3 SH3BGRL3 CTSC CDK6 ANXA2 ATP2A2 PRPF40A YWHAQ SLC7A6 CDCP1 FRG1 PTRH1 NELFCD HEL-S-66 PTPA USP1 CA12 SHOC2 SRSF10 APOPTOSIS%WIKIPATHWAYS_20260211%WP254%HOMO SAPIENS Apoptosis BIRC5 IRF7 CDKN2A BAK1 RELA TRAF3 CASP10 MAP3K1 IGF1 IGF1R FAS LTA MYC MAP2K4 TNF NFKBIA IRF6 BCL2L11 TP63 NFKBIB BCL2L1 BCL2 TNFSF10 BBC3 BOK DIABLO IGF2 TNFSF6 CASP6 IRF4 RIPK1 IRF1 PMAIP1 TRAF1 TNFRSF10B MCL1 CYCS MAPK10 BNIP3L CASP9 CASP3 TP73 CHUK APAF1 BAX TRAF2 HRK IKBKG BIRC2 PRF1 BIRC3 CASP4 JUN CASP2 TNFRSF1A DFFB DFFA NFKB1 TNFRSF25 CASP8 CRADD BAD SCAF11 PIK3R1 BCL2L2 IRF2 FADD HELLS MDM2 TNFRSF21 TRADD IKBKB TNFRSF1B IRF3 NFKBIE OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260211%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP4F8 CYP2C8 CYP2J2 CYP4F11 CYP46A1 CYP26A1 CYP2S1 CYP27C1 CYB5R3 CYP7B1 CYP26B1 CYP4V2 CYP27B1 CYP2C19 CYP3A7 CYP3A4 CYP2W1 CYP11B2 CYP27A1 CYP2R1 CYP3A43 CYP2A7 CYP8B1 CYP26C1 CYP2C9 CYP2A6 CYP2B6 CYP17A1 CYP2A13 CYP4A22 CYP2F1 CYP4B1 CYP20A1 CYP4F2 CYP4A11 CYP4F12 POR CYP51A1 CYP24A1 CYP7A1 CYB5R1 CYP11A1 CYB5R4 CYB5B CYP1A2 CYP1B1 CYP1A1 CYP4Z1 CYP2E1 CYP2U1 CYP4F22 CYP4X1 CYP2C18 CYP4F3 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260211%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma CREBBP EP300 FGFR4 CEBPA SETD2 MYC ERBB2 KDM6B ARID4B MYB MAP2K2 NCOR1 NFIB ARID5B NOTCH1 RAF1 KMT2C TLK1 SMC1A MYBL1 CHEK2 CHEK1 PIK3CA BCORL1 MAX FGF16 PRKDC FBXW7 MAML3 SRCAP JMJD1C CTBP1 HIST1H1E ARID1A CMTR2 MAGI1 DTX4 FOXO3A HIST1H2AK INSRR FOXP2 MORF4L1 ATM KAT6A MYCBP MGA KANSL1 UHRF1 PTEN BRCA1 HRAS BCOR SMARCE1 ERBIN MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260211%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MYLK PLCB2 RCAN1 CISH MYEF2 IGF1 MAP3K7IP1 IGF1R LIF CTNNB1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 GATA4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 CTF1 MAP2K1 MAPK14 NFATC4 MAP2K2 CDK9 IL6ST EGF RAF1 IKBKE FGFR2 PRKCB DVL1 PIK3R3 WNT3A EIF2B5 GSK3B PIK3CD NPPB MAP2K5 MAPK8 TGFB1 CHUK STAT3 IKBKG ROCK1 ROCK2 PIK3CA MAPK7 NFKB1 LRP5 LRP6 ARHA MAP3K14 MTOR PIK3R2 PIK3R1 CALM1 FZD1 CDK7 FZD2 FGF2 NPPA EDN1 IKBKB PPP3CA MAPK4 RAC1 CAMK2D MYLK3 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260211%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDK PDHA1 TPK1 SLC19A3 DKFZp667O1614 HEL107 SLC19A2 OGDH TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP619%HOMO SAPIENS Type II interferon signaling IFI6 STAT2 STAT1 IFNGR1 ISG15 SOCS3 SOCS1 HLA-B MHC2TA NOS2 IFNA2 PTPN11 TAP1 CYBB IRF2 OAS1 SPI1 IRF9 IFIT2 H4C9 IFNGR2 IRF4 EIF2AK2 IRF8 IRF1 GBP1 IFNB1 IFNG IL1B JAK1 CXCL9 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260211%WP5300%HOMO SAPIENS TROP2 regulatory signaling CHEK1 ITGB1 CDKN2A EGFR HEL113 IGF2R STAT1 BAX IGF1 CLDN7 JUN IGF1R SRC NFKB1 CTNNB1 CLDN1 CDK4 CDK2 TLN1 PIK3R1 NOTCH1 BCL2 CDKN1B PSEN2 ABCC1 IGF2 CCNE1 MDK PRKCA PECAM1 PTEN TACSTD2 RB1 ACVRL1 RAC1 PAK4 CCND1 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260211%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification NOTCH1 LPAR1 JAG2 ALPL PLAT CALU SOX6 VEGFA GJA5 DLL3 DLL4 ITGA1 MGP FGFR3 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway ACAT1 ACAT2 HMGCR GGPS1 IDI1 FDPS MVK HMGCS1 FDFT1 IDI2 PMVK MVD HMGCL FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation CNP STAT1 SNAI1 BMP4 ATG5 MAPK1 MAPK12 IHH MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 FGF9 MAP2K2 SOX9 RAF1 FGF18 PTHLH RBL1 CDKN1A NPR2 PTH1R PPP2CA BMP2 THRA FGFR3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260211%WP558%HOMO SAPIENS Complement and coagulation cascades TFPI C1QB PLAT C1QA PLG PROS1 C4B_2 C2 F2 HEL-S-62p HEL-S-78p C3AR1 F7 CR2 CR1 PLAUR C1QC SERPING1 MASP2 MASP1 CD46 CFD CFH CFI C5AR1 SERPINA1 CLU C6 THBD C7 C8G C9 BDKRB1 SERPINF2 F3 CD55 F2R F5 F8 F10 F9 CPB2 CLTC C1R SERPINC1 KNG1 LMAN1 SERPIND1 PROC F13B KLKB1 VWF T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260211%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection PAK1 ZAP70 GRAP2 LCP2 CDK4 CARD11 BCL10 PTPRC TNF FYN MAPK3 NFATC2 LAT MAP2K1 NFKBIA CTLA4 MAP2K2 PTPN6 RAF1 MAP3K8 MAP3K7 CD40LG IFNG PRKCQ LCK GSK3B DAG1 MAPK9 CHUK CD3D CD8A IKBKG PLCG1 IL10 JUN PIK3CA NFKB1 IL2 IL4 IL5 RRAS MAP3K14 ITK PDCD1 ICOS CALM1 CBL NCK1 FOS IKBKB CHP1 CSF2 AHSA1 GRB2 SOS1 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260211%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte LEP SMAD9 BMP7 ZNF423 PPARGC1B PPARG DGIC ZIC1 CEBPA CEBPB BMP4 CEBPG DKFZp781O1323 SLC7A10 PRDM16 PPARGC1A HSPB7 SMAD1 CIDEA EBF3 BMP2 HOXC9 HOXC8 MPZL2 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260211%WP4255%HOMO SAPIENS Non small cell lung cancer CDKN2A EGFR BAK1 NRAS BRAF ALK RASSF1 PDPK1 CDK4 HGF AKT3 RXRA ERBB2 MAPK1 EML4 SOS2 KRAS KIF5A MET MAPK3 HEL-S-61 MAP2K1 STK4 MAP2K2 TGFA EGF RAF1 E2F2 PRKCB DDB2 PRKCA RB1 STAT5B GADD45B JAK3 GADD45G CCND1 RET CYCS RARB PIK3CD FHIT POLK RXRB CASP9 RXRG CASP3 STAT3 ARAF BAX PLCG2 PLCG1 PIK3CA CASP8 BAD GADD45A CDK6 E2F3 CRABP2 CRABP1 FOXO3A CDKN1A HRAS GRB2 SOS1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260211%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer MYRIP SYTL5 RPH3A MLPH UNC13D MADD TBC1D10A SYTL2 EXPH5 RAB27A RAB27B SYTL1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260211%WP45%HOMO SAPIENS G1 to S cell cycle control MCM5 MCM6 CDKN2A CCND2 CDC45 WEE1 CDK4 MYC CDK2 RPA3 RPA1 CREB3L3 CDKN1B CREB3L4 CCND3 E2F2 CCNE2 POLE TFDP1 CDKN2D RB1 CCNB1 CDKN2B POLE2 CCNG2 CDKN2C CDC2 CCND1 PRIM2 POLA2 MYT1 CCNH CDKN1C MNAT1 GADD45A PCNA TFDP2 MCM2 CDK6 E2F3 CDK7 MDM2 CCNE1 ATM PRIM1 CREB3 CDKN1A CREB1 ORC6 ORC3 ORC2 MCM7 ORC1L MCM3 ATF6B DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260211%WP5506%HOMO SAPIENS Disorders of NAD metabolism NADSYN1 BST1 NAXE NAXD SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260211%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response IRF7 HDAC2 LAG3 STAT2 EP300 STAT1 CXCL2 TRAF3 AP1G1 NUP98 RAE1 PPBP CXCL6 IFITM1 CXCL3 CCL5 TP53I3 TNF ACE2 CCL2 CCL4 TFAP2A LARP1 MX1 CD160 PF4 IFIT2 RIPK1 IL6R hEMMPRIN TRAF5 TANK TGFB1 CXCL12 TRAF2 TRAF6 TBK1 IFNAR2 DHX58 TRIM25 IL10 HAVCR2 IFNAR1 NFKB1 IL6 CXCL8 MAVS CASP8 RIGI CXCL5 TLR7 FADD TRADD IL8RB IFNB1 CSF2 JAK1 CXCL9 CXCL17 CXCL13 CXCL11 CXCL1 IRF3 CCL3 MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260211%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer CASP9 CASP3 BBC3 APAF1 TP53AIP1 BAX MDM2 ATM EI24 SHISA5 CYS1 ZMAT3 PERP DDB2 PTEN PMAIP1 SIAH1 CASP8 TNFRSF10B SESN3 CHEK2 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260211%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 CREBBP LRP5 LRP6 PORCN TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260211%WP465%HOMO SAPIENS Tryptophan metabolism ECHS1 TDO2 IDO1 ACAT1 STAT1 ASMT TPH2 TPH1 AOC1 ALDH8A1 IL4I1 DLD DDC MAOA AOX1 ALDH2 GOT2 GCDH CYP1A1 KYAT3 KYAT1 AANAT INMT AADAT HAAO AHR KMO KYNU AFMID IDO2 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260211%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress CHEK1 MAPK8 PTGS2 TSC1 PINK1 IKBKG FOXO1 PIK3CA HMOX1 NFKB1 GSX1 IPCEF1 IL6 PIP CXCL8 MAP2K3 CDK2 MAP2K4 TNF NOS2 MAP3K5 ATF2 MAPK14 MTOR BCL2L1 BCL2 NFE2L2 NQO1 RPS6KA5 SIRT1 MDM2 CCNE1 RHEB ATR NRF1 FOS CDKN1A PTEN IKBKB CREB1 KEAP1 IL1A UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260211%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP9 CAMK2A EGFR SMAD2 CREBBP EP300 RELA CTNNB1 HDAC5 TRPC4 CDK2 MAPK1 TNF MAPK3 PTPN11 MAPK14 AGTR1 CYBB BCL2 NCF1 NCF4 ABCA1 AIFM2 CYBA COL2A1 CDC2 VCAM1 GSK3B ACTA2 NPPB COL1A1 CASP9 MAPK9 COL3A1 MAPK8 CASP3 TGFB1 CHUK ALOX5 STAT3 BAX ESPL1 HMOX1 NFKB1 PLN IL6 UTS2R DDIT3 ARHA PCNA NCF2 UTS2 CCNE1 NPPA GSK3A NOX4 PTEN IKBKB MMP2 IL1B HSPA2 IRF3 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260211%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes ACSL5 ACSL3 STAR FABP4 LPA DBI SLC27A2 SORT1 APOC2 SLC27A3 SOAT1 APOC1 LIPA PCSK9 APOA4 SCARB1 APOB LDLR MYLIP FABP1 APOE SLC27A1 ABCA1 SOAT2 SLC27A4 ACSL1 STARD3 FABP2 ACSL6 NPC2 NEPHROGENESIS%WIKIPATHWAYS_20260211%WP5052%HOMO SAPIENS Nephrogenesis BMP7 TCF21 SIX2 WNT9B RSPO3 FOXD1 OSR1 ALDH1A2 GREB1L PAX2 MEIS1 FGF20 WNT4 WNT3A RSPO1 FGF8 NOTCH2 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260211%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 CCL13 IL10RA ACKR3 CCL8 CCL7 CCL4 CCL1 CCL18 TNFRSF14 CCL15 TNLG5A LEPR ACVRL1 CCR10 CCR1 XCR1 IL2RA IL2RB IF2B1 IL23R IL15 GDF11 TNFRSF10A CD27 IL2RG IL-21 CXCL12 IL18RAP IL21R IL12RB1 IL10 CCR8 IFNGR1 EDAR CCR4 IL13 BMP8B IL2 IL4 IL5 CXCL8 IL5RA CSF2RB CCR3 IL3 IL3RA GH1 IL9 BMPR1A BMPR2 TNLG7C TNFRSF19 LTB IL1RN CXCL17 CXCL13 IF2D TGFBR2 CXCL14 IF2G IL36A CCR6 IL1A IL36B INHBA GDF5 IL36RN IL36G PPBP INHBB IFNW1 BMP4 IL1F10 CXCL6 IL24 FAS IF1IB1 IL27 CX3CR1 CXCL3 IL7 PF4V1 CSF1 IL19 XCL2 TNF IFNK XCL1 IFNL2 IFNL3 CCL20 ACKR4 CCL25 IL33 CCL24 IL31 CCL22 CCL21 IL37 CCL27 PF4 CCL26 TNFSF6 TWEAK TNFRSF12A IL1R1 ACVR2A IL27RA NGFR CSF3 CSF3R EPO IFNAR2 CNTFR TNFRSF1A IFNAR1 BMP3 CSF1R GDF10 CXCL5 GDF3 TPO IL7R NODAL TNFRSF21 IFNB1 NGF IL1R2 CXCL9 CXCL1 ACVR1B CCL3 TACI PRL CNTF EPOR CXCL2 CCR2 PRLR CCL23 CCL11 LIF LTA CX3CL1 CCL19 CCL5 CCL28 CCL2 IL15RA GHB2 IL18R1 GHR AMH CXCR4 CD40 IL25 CXCR6 IL34 IL10RB IFNGR2 IFNLR1 BMP10 TNLG7A IL6R CD40LG IFNG IL23A IL17F IL17D IL17C TNFRSF10B IL17B IL20RA IL20RB IL17A TGFB1 TNFRSF4 TNFRSF9 MPL ACVR1 IL22RA1 IL9R ACVR2B TNFSF11 GDF15 TNFRSF11A IL1RL2 TNLG2B CSF2 CXCL11 CSF2RA IL17RC IL17RB BMP6 IL17RA TGFBR1 IL11 IL11RA gdf7 TNFSF14 GDF1 GDF6 RELT IL6ST CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 BMP7 INHBC BMP5 TNFSF10 INHBE TNFRSF18 ACVR1C LTBR TNFRSF11B AMHR2 CCR7 IL1RL1 CXCR5 GDF8 LEP ANP32B BMP15 TNLG1B IL6 TNFRSF25 CCR5 IFNA2 TNFRSF13C TNFRSF10C TSLP CXCL16 CCL4L2 IL13RA1 IL8RB GDF9 IL18 TNFRSF1B CXCR1 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260211%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons GNAI1 GNG2 KCNK9 CHRNA5 TH CHRNA6 KCNK3 PPP1R1B SLC18A2 DDC DRD2 DRD3 CHRNB2 CHRNA3 DRD4 GNB1 CDK5 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260211%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGA4 ITGB1 HLA-DMA CD63 CD151 SHH HBEGF LGALS3BP HLA-DRA CHST6 EXT1 CRY2 ALKBH3 HLA-DMB CHST1 LEF1 GLI3 CD82 MAPK8IP1 IGSF8 NRXN1 CD19 SPPL2C B4GALT4 PRDM11 ACCS PHF21A C11orf96 ALX4 TP53I11 LARGE2 EXT2 PEX16 IZUMO1 ITGA6 SDCBP SLC35C1 SYT13 VANGL1 MS4A1 FREY1 REST SLC25A17 B4GAT1 TIMP1 B3GNT7 PEX3 TSPAN18 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260211%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CXCR4 TGFB1 CCR2 IL12RB1 IFNGR1 IFNGR2 IL12B CCR7 CCR4 IL12A IL2 IL4 IL5 CD40LG IFNG CCR5 CSF2 CXCR3 CCL4 IL18R1 CCR3 CCR1 CCL3 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260211%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA2 PDHA1 CHKA ACHE PEMT ChAT MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260211%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 SOCS3 MYC STAT3 CHI3L1 BAX IL6ST AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260211%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis PRKAG2 CSN1S1 EIF4E EIF4G1 TSC2 EEF2 PRKAG3 PRKAA1 CSN3 EEF2K PRKAB2 RPS6KB1 PRKAB1 CSN2 PRKAA2 RPTOR MTOR EIF4A2 PRKAG1 MLST8 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260211%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis IRAK1 TLR4 NFKB2 APOE RELA SPI1 TRAF6 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway EDN2 TSC22D3 PTGS2 SNAI2 POU5F1 B3GNT5 CDC42EP3 ACKR3 TNFAIP3 PMP2 ANGPTL4 MFGE8 IL11 RXRA NR1I3 FGD4 GPR153 CCL2 SERTAD2 CCL20 CAVIN2 PTGES3 NR1i2 KTN1 RGS2 NR3C1 DNER SCNN1A NFKB2 SLC26A2 ABHD2 DNAJC15 GADD45B ARL5B ZIC2 MGAM SRGN TGFBR3 PPP1R14C ALOX5AP NAV3 ADGRF4 BIRC2 CDKN1C BIRC3 JUN PRRG4 STOM S100P SPRY1 THBD TNS4 PDE4B BHLHB2 SLC19A2 PLK2 AMIGO2 CPEB4 EPB41L4B ENC1 ANKRD1 FGFBP1 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260211%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation NDUFB10 MEF2D RELA VAV1 SH2B3 ZAP70 GRAP2 TNFAIP3 PDPK1 LCP2 CARD11 BCL10 SOCS1 LAT NFKBIA PTPN6 CDKN1B CUL5 MAP3K8 DGKZ SH2D1A REL PRKCQ LCK RASA2 DGKA TMEM222 MAP4K1 ARIH2 CD3G UBASH3A CD3E CHUK RPRD1B CD3D FIBP CD8A CD5 TRAF6 AGO1 IKBKG PLCG1 NFKB1 ARHH MAP3K14 ITK PIK3R2 PIK3R1 RNF7 GNA13 IKBKB GRB2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260211%WP322%HOMO SAPIENS Osteoblast signaling IBSP PDGFRA COL1A1 TNFSF11 ITGB3 BGLAP PTH1R PTH TNFRSF11B SLC17A2 ITGAV FGF23 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 HEXB SCARB2 HEXA GM2A PSAP NEU1 NPC1 GLB1 NEU3 NEU4 GLA LIPA NPC2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260211%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits SRC NOTCH1 TCF7L2 TCF7L1 CXCR4 TNC LEF1 POSTN VHL VEGFA VCAM1 CYTIP GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260211%WP100%HOMO SAPIENS Glutathione metabolism GSTM2 GSTT2 GPX2 GSTA5 GSTM1 GPX3 OPLAH HEL-S-26 HEL-S-64p GPX1 GPX4 GCLM HEL-75 GCLC STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260211%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LPIN1 INSIG1 NR1H2 INS DBI YY1 PRKAA2 PRKAG1 PRKAG2 SCARB1 CAMP ACACA LDLR FASN PRKAG3 PPARGC1B PRKAA1 LPL SIRT1 PRKAB2 IDI1 FDPS NFYA PRKAB1 SREBF2 HMGCS1 MVD SAR1B HEL-S-32 CDK8 CYP51A1 MBTPS1 HMGCR ACLY PIK3CA SAR1A RNF139 SEC23B FDFT1 SEC31B SEC31A AMFR SP1 SEC24C MBTPS2 SQLE MED15 FGF21 SCD MTOR ACSS1 PPARG GPAM RBP4 SEC23A GSK3A CREB1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260211%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260211%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 IRAK4 IRF7 STAT2 MYD88 STAT1 TRAF3 TRAF6 TBK1 IFNAR2 TMPRSS2 TYK2 IFNAR1 MAVS TREML4 RIGI ACE2 TLR9 TLR7 IKBKE OAS1 OAS2 OAS3 IRF9 EIF2AK2 JAK1 IFIH1 IRF3 TLR3 INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260211%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy GLS RPS6KA2 ARAF BRAF PFKFB2 DLD RPS6KA3 MAPK1 HEL-S-30 MAPK3 CPT1A RPTOR MAP2K1 MTOR MAP2K2 HEL-75 MLST8 ACSS1 PDHA1 RAF1 NAMPT PKLR SLC16A3 RPS6KA1 LDHB HEL-S-304 HEL-S-133P DLAT PPARGC1A GPX4 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260211%WP1993%HOMO SAPIENS Angiogenesis overview PLA2G1B MMP9 BMX ANGPT1 PAK1 VEGFA GRB7 SRC KDR SHC1 PLXND1 PDPK1 MAP2K4 MAPK1 KRAS MAP2K6 ATF2 PTPN11 MAPK11 MAP2K1 MAPK14 RAF1 SLIT2 GRB14 MAP3K7 PXN F2 PRKCA ROBO4 PTK2B PIK3CD DAG1 MAPK8 CRK WAS PLCG1 NRP1 SHB TIMP4 BAD VHL MTOR APC CDC42 SEMA3A IQGAP1 FGFR1 ROBO1 NCK1 NOX4 MMP2 FRS2 RAC1 GRB2 SOS1 MMP14 CCL18 SIGNALING%WIKIPATHWAYS_20260211%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 CDH2 AK4 PTK2B CCR8 ESTROGEN METABOLISM%WIKIPATHWAYS_20260211%WP5276%HOMO SAPIENS Estrogen metabolism CYP2C8 UGT1A8 UGT2B7 CYP2C9 UGT1A10 CYP1A2 HSD17B3 CYP1B1 HSD17B7 SULT1E1 HSD17B2 CYP2C19 CYP3A7 UGT2A2 CYP3A4 HSD17B10 HSD17B4 HSD17B1 LAC PHE PATHWAY%WIKIPATHWAYS_20260211%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260211%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition SMC1A RAD21 MAD1L1 PTTG1 STAG1 CENPE CDC20 BUB1B SMC3 APC ESPL1 MAD2L1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260211%WP334%HOMO SAPIENS GPCRs class B secretin like GPR64 PTH2R CALCR ADGRL4 CRHR1 GLP1R ADGRL2 ADGRL3 ADGRE2 GHRHR PTH1R ADGRE5 ADCYAP1R1 ADGRL1 VIPR2 CRHR2 GIPR CALCRL GCGR SCTR TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260211%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways BCAT2 PSAT1 BAAT DHFR PSPH AMT CHDH GPX1 PHGDH HEL-S-44 HEL-75 GCLC pcap GAD2 CDO1 MTR HEL-S-75p GAD1 HEL-S-51e MTHFD2 TYMS DNMT3L GPX6 MAT1A HEL-S-64p GPX4 HEL-S-61p GPX2 CBS BCAT1 ALDH7A1 DNMT3B CTH GCLM AGXT2 PCYT1B CHKB AHCYL1 PCYT2 SLC25A48 CHKA BHMT2 ETNK1 AHCYL2 GPX7 PEMT MTHFD1 MTHFD2L CHPT1 GPX3 SHMT1 MTHFD1L CEPT1 HEL-S-182mP 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome NLRP3 GDF5 ChAT DKFZp781O1323 JUND ATF2 BCL2 CUL5 SMARCC2 SIRT1 EIF4ENIF1 ELOA BMP2 SF3B1 MYBBP1A MAPK8 ERCC5 RIF1 SIRT6 NEO1 HSF1 MYO1C MEN1 DLD SMAD1 PCNA SMAD9 DDX21 OGDHL FAM170B CEFIP BMPR1A VSTM4 RGMB BAZ1B NOG WDFY4 PARG LRRC18 SLC18A3 ARHGAP22 HSF4 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 ITCH UVSSA MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260211%WP2857%HOMO SAPIENS Mesodermal commitment pathway ARL4A WDCP MIXL1 C9orf72 KLF4 KLF5 GATA3 RGS10 SETD2 HAND1 CTBP2 RPL38 LEFTY1 AMH LEFTY2 ZIC5 TBX6 NR2A1 HES7 SESN1 GATA6 TCF4 C1QBP TBX1 FOXH1 TBX3 CCND1 RARB PLCH1 YAP1 CRTC1 PIAS1 TRIM28 NABP2 DKK1 ACVR1 SMAD1 DNMT3B ACVR2B SCHIP1 SMAD6 BHLHB2 FZD5 BMPR1A FZD8 BMPR2 LATS1 TEAD2 SMAD2 SMAD4 INHBA SLC2A12 HTT TET1 FOXC2 FOXC1 SNAI1 BMP4 POU5F1 CUL4B PITX2 PAX6 MEIS1 SOX2 FOXA1 ARID5B CCDC6 ACACA BMP7 NFE2L2 FOXA2 LEF1 TCF7L1 HMGA2 ACVR2A WNT3 PRKAR1A WNT3A PPP2CA ZIC2 SOX21 SOX17 CEP250 WDHD1 AXIN1 EMSY AXIN2 WDFY2 HPRT1 BCORL1 TOX CSRP2 NLK MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 FGF8 GDF3 ZFHX4 TRERF1 PBX1 EXT1 FZD4 NODAL FGFR1 TRIM71 PHF6 ZIC3 TRIM5 JARID2 VAV3 NOG PARP8 NR1B3 TOX3 AEBP2 EXT2 AHDC1 ZNF462 ADAM19 ELP4 TWSG1 MSGN1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260211%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TAF13 TBP H4C9 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260211%WP186%HOMO SAPIENS Homologous recombination POLD4 RAD51 RAD54B BRCA2 MRE11A POLD2 ATM RAD52 RPA1 NBN POLD3 RAD50 TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260211%WP2113%HOMO SAPIENS Type III interferon signaling IF1IB1 TYK2 STAT2 STAT1 IRF9 JAK1 IFNL2 IFNL3 IL10RB IFNLR1 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260211%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND2 ND5 ND4 TIMMDC1 ND6 NDUFB10 TMEM186 C3orf60 TMEM126B DMAC1 NDUFB11 DMAC2 COA1 NDUFAF6 NDUFAF4 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 ACAD9 NDUFB9 NDUFB8 NDUFAF1 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 ECSIT NDUFA3 NDUFA2 ND4L NDUFAB1 NDUFA13 NUBPL NDUFAF2 NDUFS3 NDUFA12 NDUFA10 ND1 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260211%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260211%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer TSC2 TSC1 ARAF MAPKAP1 NRAS BRAF PIK3CA AKT3 IRS1 EIF4EBP1 MAPK1 KRAS SOS2 MAPK3 RPTOR MAP2K1 MTOR DEPTOR MAP2K2 PIK3R1 MLST8 PARP2 PARP1 RAF1 RPS6KB1 AKT1S1 INPP4B PTEN RICTOR HRAS GRB2 SOS1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260211%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3CA PIK3R5 PIK3CD PIK3R3 PIK3C2G PIK3C2A PIK3C2B PIK3R4 PIK3R2 PIK3R1 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260211%WP1455%HOMO SAPIENS Serotonin transporter activity STX1A IL1R1 TGFB1I1 IL1B MAOA ITGB3 TPH2 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260211%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum XAB2 POLK XPA GPS1 XPC CUL4A POLE4 RFC2 GTF2H2C_2 DDB1 CCNH GTF2H2 RFC3 GTF2H3 RFC4 SLX4IP GTF2H5 CUL4B SLX4 ERCC2 MNAT1 RBX1 CHD1L RPA3 RPA1 ERCC1 PCNA CETN2 PARP1 CDK7 HMGN1 H4C9 POLD3 H2AC6 RFC1 POLD4 HIST1H4L DDB2 POLE RAD18 BRCA1 H3F3B LIG1 POLE2 POLD2 POLE3 UVSSA 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B SMAD2 SMAD4 C1QTNF12 VEGFA COMMD1 PANK4 INTS11 ISG15 INTS13 INTS14 INTS10 GDE1 TMEM52 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 SAMD11 MUSK SSU72 TNFRSF14 PEX2 ATAD3C GLTPD1 ACAP3 ELAVL1 RER1 CD160 SCNN1D PEX5 MXRA8 TNFRSF18 VWA1 AURKAIP1 TNLG2A PERM1 KLHL17 PEX12 MEPCE PUSL1 TAS1R3 NADK HES4 MRPL20 OR4F5 DVL1 HES5 OR4F3 CDK11A CFAP74 MIB2 PEX10 RNF223 LRP4 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 TRAF5 INTS9 SLC35E2B C1orf159 PLCH2 PRKCZ TGFB1 CALML6 GRIK2 DKK3 ARF6 TRAF2 TRIM25 TNFRSF4 PARD6B PHKG2 RBX1 VTN GNB1 AGRN MCM2 HEL-S-72p IFIT1 ATAD3A UBE2J2 SKI TNLG2B B3GALT6 INTS4 IFIH1 BTLA DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260211%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens MARS1 OMA1 LONP2 TSC2 SESN2 TSC1 GDF15 LONP1 FOXO1 SLC7A7 EIF2A CLPP MYC IRS1 PHB2 MTOR HSPD1 ATF4 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260211%WP5145%HOMO SAPIENS COVID 19 structural coverage map TOMM70 SLC6A19 AQR UPF2 IGHMBP2 GDAP2 NLRP12 UBB MACROD1 HEL97 MACROD2 CMTR1 MAP3K7IP1 NRP1 ISG15 PAIP1 PARP14 UBC PALS1 MACROH2A1 ACE2 MACROH2A2 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling ITGB1 PIK3CD MAPK10 EGFR COL1A1 MAPK9 MAPK8 NRAS SRC AKT3 TLN1 MAPK1 MAPK12 KRAS MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RAF1 PXN ITGA1 HRAS GRB2 AREG SOS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260211%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance ERN1 SLC2A4 CD36 PRKCZ PRKAG3 MAPK8 INSR PDX1 RPS6KB1 EIF2AK2 TNFRSF1A INS IRS1 TNF TRAF1 MAFA PPP2CA ACSL1 PIK3R1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260211%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 IL1B RELA TRAF3 PYCARD NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CCND2 KLF4 EZH2 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CTBP2 CHD8 RYK ROR1 WNT5B ELAVL1 WIF1 SOST LEF1 CCND3 NKD1 NKD2 DVL1 DVL2 TCF7L2 DVL3 TCF7L1 SOX7 WNT1 WNT3 CTNNBIP1 WNT4 KREMEN1 WNT3A SENP2 SFRP5 CCND1 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 FZD10 ROR2 MTDH FRAT1 FRAT2 WNT16 JUN CSNK2A1 CSNK2A3 CSNK2A2 CSNK1E DKK1 DKK2 LRP5 NLK DKK4 SFRP4 LRP6 CSNK2B APC CSNK1A1L CTBP1 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP4925%HOMO SAPIENS Unfolded protein response ERN1 BCL2 NFE2L2 MBTPS1 BBC3 XBP1 RTCB HEL-S-89n CASP2 MBTPS2 IL1B PMAIP1 DDIT3 TXNIP TNFRSF10B EIF2S1 PPP1R15A BCL2L11 ATF4 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260211%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair PRKDC NASP MDC1 ATM H1-1 RNF168 H4C9 NBN HIST1H4L RAD51 TP53BP1 SETD2 RNF8 SUPT16H XRCC5 SSRP1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260211%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 FADD CASP9 CASP3 BAX TRAF2 BIRC3 RIPK3 TNFRSF1A RIPK1 TRADD TNF CASP8 CYCS MTHFR DEFICIENCY%WIKIPATHWAYS_20260211%WP4288%HOMO SAPIENS MTHFR deficiency MARS1 CASP9 CHKA CASP3 PEMT ASMT CHPT1 GRIN1 EHMT1 ALDH7A1 CHDH DNMT3B HEL-S-61p CYCS 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260211%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome ATP2A1 RABEP2 SH2B1 INSR TRAF2 SLN NFATC2IP VAV2 TUFM ATXN2L SPNS1 KDR IFITM1 PLN IL4 SDCCAG8 MPL NFATC2 LAT RAB5A CD81 CD82 CD19 PRMT1 HEL-S-62p CR2 RAB4A TRAF1 GRB2 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260211%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMPR2 NOG SMAD6 TOB2 SMAD4 RUNX2 SMURF1 SMAD1 BMP2 TOB1 BMPR1A RANKL RANK SIGNALING%WIKIPATHWAYS_20260211%WP2018%HOMO SAPIENS RANKL RANK signaling MAPK9 PAPSS2 MAPK8 RELA CHUK STAT1 TRAF3 FHL2 RELB TRAF2 GAB2 TRAF6 PLCG1 IKBKG MAP3K7IP1 JUN SRC NFATC1 NFKB1 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 MTOR NFKBIA LYN PIK3R2 SYK PIK3R1 CDC42 TNFSF11 SPI1 TNFRSF11B CBL TNFRSF11A MAP3K7 FOS NFKB2 SQSTM1 IKBKB RAC1 TRAF1 TRAF5 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260211%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NFE2L2 MAPK8 NQO1 CEBPB EPHB2 PIK3CA SLC7A11 HMOX1 PRKCA MAF GCLM AIMP2 KEAP1 GCLC INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260211%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy RAB11B PMP22 FIG4 MPZ MFN2 KIF1B RABAC1 MTMR2 EGR2 RAB7A LRSAM1 RAB4B HSPB8 LITAF GDAP1 SH3TC2 FGD4 RAB25 HEL-S-102 RAB4A RAB11A NEFL SBF2 RAB3B ONE CARBON METABOLISM%WIKIPATHWAYS_20260211%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR AHCYL2 MTHFD1 SHMT1 HEL-S-51e MTHFD1L TYMS MTHFD2 DHFR MAT1A AMT TCN2 HEL-S-70p CHDH MTFMT GLRX DNMT3B MTHFS FOLH1 HEL-S-61p FTCD NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260211%WP5399%HOMO SAPIENS NPHP1 deletion syndrome FLNB MAPK1 FLNA MAPK3 PTK2B RPGRIP1L INVS NPHP1 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5153%HOMO SAPIENS N glycan biosynthesis DOLPP1 MGAT4B STT3A STT3B ALG1 FUT8 B4GALT1 DPM2 MGAT1 MPDU1 B4GALT2 TUSC3 ALG6 DPAGT1 GMPPB MAN1A2 MAN1A1 ALG8 ST6GAL1 ALG9 ST6GAL2 ALG5 ALG2 ALG14 RFT1 ALG13 ALG3 ALG12 ALG11 ALG10 DDOST DPM3 GCS1 MAN1B1 ALG10B DPM1 RPN2 RPN1 GANAB MAN2A2 MAN2A1 MGAT5B MGAT5 MGAT3 MGAT2 SRD5A3 DOLK MGAT4C MGAT4D MGAT4A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260211%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions FOXO6 WWTR1 KNSTRN RAB13 FERMT3 YAP1 FOXO1 FOXP3 RAP1A ARHA STK38L FYB1 MAPK14 MOB1A PRDM1 LPL FOXO4 FOXO3A YWHAQ CD19 CCR7 LATS1 TEAD4 LATS2 RAC1 TEAD2 TEAD3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260211%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 TLR4 IRAK4 IRF7 MYD88 TICAM2 RELA CHUK TRAF3 RELB TIRAP TRAF6 TBK1 IKBKG NFKB1 TLR5 MAPK1 TLR9 TLR7 IKBKE TLR1 TICAM1 NFKB2 IKBKB REL IRF3 TLR8 TLR3 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling TLR4 TIFA IRF7 CISH TREM1 SOCS1 CCL5 RBCK1 CCL4 NFKBIA PTPN6 MLST8 IKBKE CD40 CD80 IFNA6 MAP3K8 TLR1 IL12B MAP3K7 IL12A PIK3R3 SQSTM1 MBL2 MAPK10 MAPK9 MAPK8 SFTPA2 LBP CYLD TLR5 CXCL8 CASP8 SPP1 ZMYND11 PIK3R2 SYK PIK3R1 PLK1 IRAK3 PELI1 SMAD6 FADD IKBKB RAC1 CXCL11 IRF3 CD14 TLR8 TLR3 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 TICAM2 RELA STAT1 FBXW5 LY96 IFNA21 TRAF3 CD180 IF1AA9 TRAFD1 TIRAP SIGIRR CUEDC2 SFTPD MAP3K7IP1 RNF31 PELI3 SARM1 TNFAIP3 IFNA8 AKT3 MAP2K3 MAP2K4 MAPK1 TNF MAPK12 MAP2K6 MAPK3 MAPK13 MAPK11 MAP2K1 MAPK14 MAP2K2 RIPK1 IFNA7 TICAM1 NFKB2 BTK IRAK1 IRAK2 PIK3CD IRAK4 TAB3 MYD88 OTUD5 CHUK TRAF6 TBK1 IFNAR2 IKBKG JUN PIK3CA IFNAR1 NFKB1 IL6 IFNA2 TLR9 TLR7 TMED7 PIK3R5 RNF41 FOS IFNB1 IL1B CXCL9 IFNA1 CCL3 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260211%WP530%HOMO SAPIENS Cytokines and inflammatory response IL15 TGFB1 CSF3 CXCL2 PDGFA IL10 IL13 HLA-DRB1 IL2 IL4 IL6 IL5 IL7 CSF1 IL11 TNF HLA-DRA IL3 IL12B IFNB1 IFNG IL1B CSF2 CXCL1 IL1A PROTEASOME DEGRADATION%WIKIPATHWAYS_20260211%WP183%HOMO SAPIENS Proteasome degradation PSMC4 PSMA4 PSMA2 PSMC1 PSMB6 PSMB2 PSMB3 NEDD4 UBE2D1 PSMD9 PSMB10 HLA-A UBE2B HEL-S-276 PSMD6 PSMB8 HLA-B HEL-S-283 PSMD7 HLA-F PSME2 HLA-G HLA-C HLA-E PSMD4 PSMD5 PSMD2 UBE2D3 PSMD3 PSMD1 UBE2D2 H2AX UBB HIST1H2AB H2AZ1 PSMD10 UBA7 PSMD12 PSMD11 HEL-117 HEL-S-91n PSMD13 RPN2 UBC RPN1 IFNG PSMC6 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260211%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RARA RXRA NR1i1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260211%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways MEF2C CREBBP EP300 CTCF ASCL1 CAV3 CEBPB SCN3B NKX2-2 BDNF GATA3 SNTA1 GATA2 SCN4B HDAC9 NKX3-1 YBX1 TLX3 POU3F2 PHOX2B C4B_2 SST POU2F2 C4A IL6R TCF3 DLX2 HIF1A G6PC1 GCK TF RORA MAP2 PAH IL10 HEL-S-162eP IL13 CXCL8 CHRNB2 CPT1A ECE1 EN1 BHLHB2 CREM PPARGC1A IL1RN EGR1 FREP1 IL1A AQP4 TACR1 SLC9A3 FOXM1 VEGFA TPH2 POU5F1 TPH1 ChAT GRIN1 FEV CTNNB1 PKNOX1 TNF TSPYL1 CHRNB4 DEAF1 SPTBN1 PHOX2A SOX2 MYB NR3A2 CC2D1A HEL2 NOS1AP KCNJ8 GPD1L HEL-S-125m LMX1B AVP CHRNA7 PPARGC1B HADHB 5HT1A GJA1 NR3C1 HDAC1 NEUROD1 HES1 NFYA HES5 NFKB2 PRKAR1B PRKAR1A REST SP3 RET ACADM CHRM2 SCN5A TP73 CASP3 HTR2A JUN NFKB1 SLC25A4 IL6 NTRK2 SP1 DDC NR1A2 MAOA HEL-S-87p ADCYAP1R1 VIPR2 GNB3 SNAP25 PBX1 SSTR2 RYR2 SLC1A3 YWHAQ TH HEL-S-1 YWHAG YWHAZ NGF CREB1 RUNX3 IL1B HSPD1 VAMP2 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C8 CYP2C19 CYP2C9 CYP2B6 CYP2C18 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SRRM3 TMEM120B MDH2 TMEM120A SSC4D POR RAF1 STYXL1 HEL163 PTPMT1 KIF1C SFN EPB41L3 YWHAG LMNA RHBDD2 ZP3 ZP2 HEL-S-102 DAPK2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260211%WP585%HOMO SAPIENS Interferon type I signaling STAT2 STAT1 MAPKAP1 GAB2 MAP3K1 VAV1 ZAP70 TYK2 SOCS3 SOCS1 IRS1 MAP2K3 EIF4EBP1 PTPRC FYN MAP2K6 RPTOR PTPN11 MAPK14 PTPN6 MLST8 EIF4E EIF4B RPS6KA4 RPS6 IRF9 RPS6KA5 RPS6KB1 PRMT1 REL LCK PIK3CD STAT3 STAT4 IFNAR2 CRK PIAS1 IFNAR1 RAP1A CRKL MTOR PIK3R2 PIK3R1 EIF4A1 RAPGEF1 CBL CREB1 RAC1 JAK1 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260211%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD AGPS LPIN1 IPMK LPIN2 PIK3CA HMFN0839 PLA2G2A PI4K2A PTDSS1 CHKB PCYT2 PTPMT1 GPAM PEMT MOGAT3 GPD1 CHPT1 PGS1 CEPT1 CRLS1 GPAT2 GPAT4 CDS2 PIP5K1A GNPAT CDIPT RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260211%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation PIK3CA CMKLR1 PIK3CD FPR2 EPHB2 MTOR GRK1 LTB4R HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260211%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HMFN0839 CD36 HIF1A HEL-S-133P PPARG GPD1 HEL-S-49 HEL-S-162eP NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260211%WP404%HOMO SAPIENS Nucleotide metabolism RRM1 RRM2 POLA1 MTHFD2 OAZ1 DHFR HPRT1 POLG RRM2B ADSL NME2 SRM IMPDH1 ADSS FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 FABP4 CEBPA KLF5 INS PIK3CA GATA3 GATA2 PLIN1 NR1C1 MGLL KLF2 LMNB2 PNPLA2 PPARG LPL LIPE ZMPSTE24 FNTA BANF1 LMNA CIDEC ICMT PRRX1 STAT5B CIDEA SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260211%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 SLC6A19 FURIN ACAT1 CTSL TMPRSS4 ACE2 NRP1 TLR7 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260211%WP325%HOMO SAPIENS Triacylglyceride synthesis PLPP1 AGPS LPL GPAM MOGAT3 GPD1 LIPF LIPE AGPAT4 AGPAT5 MOGAT2 MOGAT1 AGPAT3 DGAT1 GNPAT LIPC DGAT2 PLPP3 PNPLA2 PLPP2 INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260211%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IRAK1 TIFA UBE2V1 NFKB1 SQSTM1 PRKCZ HEL-S-71 TRAF6 IL1A AJUBA SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260211%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling RAF1 RASGRF1 HTR2B NRAS HTR2A GATA4 MAPK1 KRAS MAPK3 HRAS MAP2K1 MAP2K2 MAPKAPK2 MAPK CASCADE%WIKIPATHWAYS_20260211%WP422%HOMO SAPIENS MAPK cascade MAPK10 MAP2 ARAF MBP NRAS BRAF MAP3K1 MAP3K2 JUN LAMTOR3 RRAS MAP2K3 MAPK1 MAP2K4 MAPK12 KRAS SOS2 MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 RASA3 RAF1 SIPA1 PLCB3 HRAS GRB2 MAP3K12 SOS1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260211%WP3287%HOMO SAPIENS Overview of nanoparticle effects BCL2 PIK3CD PTGS2 BAX CRP CCND3 COL4A1 HMOX1 PTGS1 IL6 NFRKB AKT3 CXCL8 TNF LAMA3 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260211%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing OAS1 TREX1 RNASEL ADAR RNASEH2C IFNB1 RNASEH2B RNASEH2A MAVS RNASET2 CGAS RIGI MITA IFIH1 IRF3 CILIOPATHIES%WIKIPATHWAYS_20260211%WP4803%HOMO SAPIENS Ciliopathies USP9X ADCY6 XPNPEP3 DYNC2I2 CEP19 INVS NPHP3 DYNC2H1 DYNLT2B SUFU DYNC2LI1 KIF7 OCRL RP1L1 IFT172 PKD1 DNAJB13 PIK3R4 RSPH9 SMO AHI-1 IFT81 TCTN3 CENPF GPR161 TCTN2 INTU TCTN1 RSPH3 ALMS1 HEL-S-296 IFT27 CC2D2A RPGRIP1L RSPH1 TMEM138 SPAG1 NPHP1 TULP1 PIBF1 CPLANE1 TMEM231 TMEM17 TMEM237 UNC119 C2CD3 B9D1 RAB23 B9D2 CCDC41 KIAA0753 CCDC40 OFD1 ANKS3 BBIP1 PDE6D NEK9 PLK4 ZNF423 CRX TRAF3IP1 CEP164 FLCN IFT52 TMEM107 ODAD1 CNGA1 ODAD3 NEK1 ODAD4 BBS9 CCDC28B BBS7 MCIDAS IFT57 NME7 TBC1D32 BBS5 NEK2 CEP290 DNAAF3 DNAAF2 ZIC2 BBS4 DNAAF6 IQCB1 CFAP418 FAM161A CCNQ IFT140 IFT80 CCNO CFAP410 AK7 CEP78 WDR35 LZTFL1 DNAAF19 ARL2BP EVC DNAL1 BBS10 DNAAF11 IFT43 HYDIN BBS12 CCDC39 RP2 MAK CFAP52 DNAI2 TMEM216 TOPORS EFHC1 WDPCP RP1 NME9 WDR51B CNGB1 ZMYND10 SDCCAG8 CEP104 KIZ ARL6 CFAP53 ARL3 KATNIP DNAH6 PKD1L1 PKHD1 CFAP298 ARL13B POC1A TMEM67 RAB28 INPP5E DNAI1 EVC2 TUB BBS2 DYX1C1 NEK8 RPGRIP1 BBS1 TTLL5 PCARE HYLS1 SCLT1 ATXN10 DCDC2 TTC8 MKS1 CEP41 TRIM32 GLI3 CLUAP1 DRC1 CHOLESTASIS%WIKIPATHWAYS_20260211%WP5238%HOMO SAPIENS Cholestasis SCARB1 NR1H4 LDLR SLC22A1 ABCC2 ABCB4 SLCO1A2 HMGCR ABCC3 ABCB11 EPHX1 RXRA NR1I3 ABCG8 ABCG5 ATP8B1 MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260211%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 GOT2 SLC25A12 GLUD1 SLC25A13 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260211%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYP11A1 SRD5A2 POR HSD17B6 STAR AKR1C4 AKR1C2 HSD17B3 CYP17A1 HSD3B2 FOLATE METABOLISM%WIKIPATHWAYS_20260211%WP176%HOMO SAPIENS Folate metabolism RELA INSR CRP FLAD1 DHFR INS CSF1 TNF GPX1 CCL2 HEL-S-44 SCARB1 APOB SERPINA3 LDLR SLC19A1 MTRR SAA4 HBB MTR PLAT FOLR1 PLG HEL-S-51e MPO MTHFD2 ABCA1 FGA HBA2 GPX6 MAT1A F2 HEL-S-78p NFKB2 F7 IFNG ALB SAA1 SAA2 GPX4 GPX2 CBS NFKB1 IL2 IL4 IL6 CTH MTHFS SLC46A1 IZUMO1R FOLR3 MTHFD1 FOLR2 GPX3 SHMT1 IL1B INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260211%WP185%HOMO SAPIENS Integrin mediated cell adhesion ITGB1 PAK1 ARHGEF7 VASP CAV3 BRAF VAV2 CAPN3 DOCK1 SRC SHC1 ZYX PDPK1 AKT3 MAP2K3 MAPK1 MAPK12 FYN MAP2K6 MYLK2 MAP2K1 SHC3 MAP2K2 HEL-S-28 RAF1 HEL114 ITGB3 ITGA2B RAC3 PXN CAPN10 ITGA1 PAK6 SELENOP PAK4 ITGA2 ITGA4 MAPK10 ITGB7 MAP2K5 ARAF RHO CRK ROCK1 CAPNS1 ROCK2 MAPK7 RAP1A CAV2 TLN1 PIK3R2 CDC42 RAPGEF1 MYPN ITGAM ITGB5 ITGB4 CAPN9 CAPN6 ITGAE CAPN7 CAPN5 ITGB8 TNS1 ITGAV GIT2 ITGAX ITGB6 CAPN11 VAV3 MAPK6 ITGA7 ITGA6 MAPK4 RAC1 HRAS CSK GRB2 SOS1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260211%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly CHAF1B HIST1H4L H2BC12 CHAF1A RBBP4 HIRA H4C9 SMIM40 IL18 SIGNALING%WIKIPATHWAYS_20260211%WP4754%HOMO SAPIENS IL18 signaling TICAM2 RELA CEBPB FAS CTNNB1 CSN2 MAPK1 TNF MAPK3 IL18R1 NFATC4 NFKBIA ELAVL1 IL37 PRKAA1 TNFSF6 NCF1 RPS6KB1 PRKCB MAP3K7 IRF1 PRKCA ACACB HEL-S-102 LCK CYCS GSK3B IRAK1 MAPK9 MYD88 CASP3 CHUK IL18RAP BAX TRAF6 TNFRSF1A GATA1 NFKB1 SP1 CASP8 PIK3R1 PARP1 NCF2 IMP3 SLC12A3 GRIN2B PTEN IL18 IKBKB NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260211%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium GSK3B MAP1B MEF2C GHRL NGFR APP ID2 ASCL1 MAP2 STAT3 CXCL12 MRE11A ID1 BDNF KDM1A PLXND1 CDK5R1 MYC NTRK2 PAX6 NRG1 ERBB4 DAB1 AGRN SOX2 DISC1 NUMB NOTCH1 PSEN1 PAFAH1B1 NEUROD1 RTN4 NDEL1 HES1 TCF4 LRP8 NTRK1 TCF3 NEUROG3 FAIM NTRK3 NGF RELN VLDLR CDK5 IL17A RET RTN4R CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260211%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP3K1 IGF1 TGFBR1 PDPK1 HDAC5 PRKG1 MAP2K3 NRG1 HDAC9 MAP2K4 HDAC7 MAPK1 PLA2G2A TNF MAPK3 MAP2K6 NFATC2 MAP2K1 MAPK14 MAP2K2 CDK9 EGF RAF1 IKBKE FGFR2 MAP3K7 PRKCA PRKD1 GSK3B MAP2K5 MAP4K1 MAPK8 TGFB1 CHUK IKBKG TNFRSF1A MAPK7 NFKB1 MAP3K14 MTOR CALM1 CDK7 FGF2 NPPA GUCA1A IKBKB PPP3CA RAC1 CAMK2D 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome METTL27 STX1A FKBP6 VPS28 ATPAF1 TRIM50 HDAC2 FBLN2 ATP8 FBLN5 ATP6 MVB12A CLASP2 ATP5MC2 TMEM270 TBL2 ATP5MC3 GTF2IRD1 FAS CTNNB1 CLDN1 MYC ATP5G1 PRKG1 NRG1 HDAC6 MAPK3 ABHD11 TSG101 ACACA MLXIPL H2AX USF1 HEL-S-123m FBN1 EIF4H ATP5PB EIF2A ATP5F1D GTF2I ATP5F1E SQSTM1 ACACB ATP5PO RB1 BTK SF3B1 ATF4 MYBBP1A HEL-S-15 HMGA1 RFC2 CHTF18 CLDN3 UBE2L6 CDKN1C HEL-S-162eP MYO1C CLASP1 DLD LIMK1 GRIP1 ULK1 SNAP25 CLDN5 CLTC PCNA CLDN4 BRD4 LAT2 PKLR NUP62 DDX21 UBIAD1 FZD9 OGDH BAZ1B BCL7B BUD23 VPS9D1 HDAC3 ATPAF2 UBE2E3 SMARCA5 VPS37C HSPA2 DEK HEL-S-271 UBE2E1 VPS37D GRB2 VPS37A HOXC8 VPS37B CLIP2 VAMP2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260211%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PLCB4 TLR4 CAMK2A PLCB1 PLCB2 STAT2 STAT1 IFI44L NRAS IFI27L2 CAMK2G RSAD2 TYK2 ISG15 CYP27B1 RXRA MAPK1 TNF NR1i1 MAPK12 KRAS MAPK3 MAPK13 CCL2 MAPK11 MAPK14 CAMP OAS2 DEFB4B CD40 PRKCH IFNGR2 PRKCB PRKCE PRKCA NFKB2 CD40LG IFNG PRKCQ SP3 RXRB NOD2 PRKCZ MAPK9 RXRG CYP24A1 MAPK8 RELB PLCG2 IFNAR2 IFNGR1 JUN TNFRSF1A MAPK7 NFKB1 IL6 SP1 CXCL8 IFNA2 PLCE1 PLCB3 IKBKB JAK1 HRAS CAMK2D TLR8 MED1 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260211%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17RC IL17RA IL17A SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260211%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD NFKB1 HMGB1 IKBKB THBD CHUK RELA NFKBIA IKBKG AGER MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260211%WP391%HOMO SAPIENS Mitochondrial gene expression GABPB1 TFAM PPARGC1B MYEF2 HCFC1 POLRMT GABPA MTERF3 MTERF1 NRF1 SP1 CREB1 PPP3CA PPARGC1A TFB1M TFB2M PPRC1 ESRRA CAMK4 DNA REPAIR PATHWAYS FULL NETWORK%WIKIPATHWAYS_20260211%WP4946%HOMO SAPIENS DNA repair pathways full network RAD54B SMUG1 REV3L ERCC2 POLI FANCD2 FAN1 H2AX FEN1 MPG PNKP OGG1 NBN UNG RFC1 POLD3 POLD4 NTHL1 DDB2 POLL POLE MUTYH MBD4 LIG1 APEX2 NEIL3 POLE2 NEIL2 APEX1 POLE3 RAD52 CHEK1 WDR48 XPA XPC CUL4A ERCC5 RFC2 GTF2H2C_2 CCNH MSH6 GTF2H2 FAAP24 GTF2H3 MSH2 BRIP1 GTF2H5 FANCM MNAT1 CENPX RAP1A FANCL REV1 WRN FANCA POLM NHEJ1 FANCC FANCB FANCE PALB2 FANCG FANCF RAD51C PARP2 ERCC1 CENPS CETN2 CDK7 ATM ATR BRCA1 BRCA2 POLD2 XRCC5 TDG POLE4 MRE11A MSH3 DDB1 RAD50 CUL4B RAD51 HMGB1 RPA3 RPA1 MGMT POLK RFC3 RFC4 RBX1 PRKDC PCNA PARP1 TERF2 PMS2 USP1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260211%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex TAF5 MED23 TAF8 MED27 MED19 MED16 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED28 MED22 MED25 MED24 MED21 GTF2A1 MED30 MED31 POLR2M POLR2L TAF10 TAF11 MED14 TRFP CRSP9 TAF1 TAF4 TAF3 POLR2A THRA CDK8 POLR2D GTF2B TAF9 CTDP1 GTF2E2 POLR2B POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K TAF13 MED15 TAF7 TAF6 TBP CCNC TAF12 MED9 NELFB NELFCD NELFA POLR2C MED1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260211%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1D HTR1B HTR1F GNAI1 STAT3 BRAF HTR2A MAP3K1 GNAI3 PIK3CA MAPKAPK3 PDPK1 RAP1A MAP2K3 MAPK1 ARHA MAP2K6 MAPK3 MAP2K1 MAPK14 MAP2K2 GNAO1 5HT1A RASGRF1 RPS6KA5 FOS CREB1 MAPKAPK2 HTR1E GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260211%WP4157%HOMO SAPIENS GABA metabolism aka GHB HEL-S-166mP ADHFE1 GLS ALDH5A1 GAD2 GLS2 GAD1 PON3 ABAT NAD METABOLISM%WIKIPATHWAYS_20260211%WP3644%HOMO SAPIENS NAD metabolism NMNAT1 PARP1 NAMPT SIRT1 SIRT3 SIRT6 NADK NRK SIRT4 NT5E SIRT5 SIRT7 NMNAT3 NMNAT2 SIRT2 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260211%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MEF2C MMP9 BMP6 RUNX2 STAT1 SOX6 IGF1 SOX5 ACAN VEGFA IGF1R ADAMTS5 GHR TIMP3 BMP7 ALPL PLAT IGF2 DDR2 PTH ENPP1 PTHLH HMGCS1 CAB39 COL2A1 KIF3A PTH1R STAT5B ADAMTS4 NKX3-2 CST5 SCIN THRA MGP TGFB1 CDKN1C COL10A1 FRZB IHH SPP1 PTCH1 SOX9 CALM1 GH1 FGF18 FGFR1 GLI3 FGF2 BMPR1A RUNX3 CHST11 FGFR3 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260211%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GCK UXS1 PGM3 HK3 HK2 GFPT1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260211%WP1531%HOMO SAPIENS Vitamin D metabolism RXRB GC CYP27B1 CYP24A1 RXRA DHCR7 NR1i1 PTH CYP27A1 CYP2R1 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260211%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260211%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production TRH RAF1 PRKAA1 NFKB1 PRKCA DUOX1 RAP1A CLCN5 CREB1 HEL-S-5 PRKAA2 SLC5A5 MAPK1 DUOX2 MAPK3 TSHR MAP2K1 TG MAP2K2 CGA TPO NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260211%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6R IL6 SOX4 IL11 STAT3 RELA IL11RA JAK1 JAK3 IL6ST PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260211%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation HSD11B1 HSD11B2 PTGER1 PTGER3 PRL PTGS2 ANXA6 EDNRA AKR1C1 AKR1C2 S100A6 SOX9 EDNRB CYP11A1 ANXA2 PPARGC1B PPARG PTGFR HPGD AKR1B1 EDN1 PTGS1 HEL-S-7 TBXA2R PTGDR PTGIR PTGIS PTGFRN PPARGC1A ANXA3 PTGER4 ANXA4 ANXA1 SCGB1A1 PTGER2 S100A10 PTGES ZINC HOMEOSTASIS%WIKIPATHWAYS_20260211%WP3529%HOMO SAPIENS Zinc homeostasis SLC30A8 SLC30A2 SLC30A5 SLC39A14 SLC30A4 SLC30A1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC39A8 MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260211%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACSL3 HSD17B10 EHHADH ACADSB ACADL DECR1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260211%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 ALOX15 EPHX2 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260211%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling ADCY3 PLCB1 MYL12B GNG2 STAT1 BRAF IGF1R SRC PDPK1 CDK4 MAP2K3 CDK2 MAPK1 MAPK3 MAP2K6 MAP2K1 MAPK14 RAF1 CDKN1B RPS6 CCND3 RPS6KB1 RBL2 RB1 APEX1 KCNIP3 GNAI1 STAT3 TSHB RAP1GAP SCRIB GNAI3 PIK3CA RAP1A GNB1 GNAS TSHR MTOR CGA GNAO1 PIK3R2 PIK3R1 CCNE1 RPS6KA1 PDE4D GNA13 CREB1 JAK1 HRAS PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260211%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NOTCH1 RBPJL CTNNB1 FGF10 PTF1A PDX1 RBPJ KAT2B PROX1 NKX6-1 HES1 MALE INFERTILITY%WIKIPATHWAYS_20260211%WP4673%HOMO SAPIENS Male infertility MMP9 SRD5A2 CREBBP SIRPA EP300 CHD2 SOX5 TRIP13 ERCC2 CYP26B1 HLA-DRA PON2 CDK9 PON1 APOB TMEM132E CYP17A1 RFC1 PEX10 AHR HMGA1 XPC CCNK PRDM9 REC8 SIRPG EPSTI1 RAG1 NANOS1 PRM2 PRM3 SPATA17 TSSK4 DDX4 DAZ4 THBS1 DAZ3 VCX DAZ2 CLU MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 FOLH1 PIWIL4 GNAO1 SPO11 XRCC3 HORMAD2 MSMB ERCC1 PRMT6 PACRG TEX15 CXXC1 ABLIM1 OR2W3 P1 USP26 NQO1 CDC42BPA MDM2 MLH3 ATM CTCFL ABCB1 SEMG1 CYP1A1 BRDT BRCA2 MMP2 DND1 FAT10 XRCC5 INSR PSAT1 KDM3A FAS AHRR UBE2B TNF MAS1L GPX1 NR3A2 BCL2 MTRR SLC16A7 NFE2L2 MTR TNFSF6 TCN2 MSH4 HEL-S-61p AGO2 STRA8 POLG HEL110 NOS2 PARP1 SLC46A1 PEMT MTHFD1 SHMT1 H4C9 DAZL PMS2 H3-4 ETV5 HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260211%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease ANGPT2 SMAD2 LTBP1 SMAD4 MAPK8 NR2C2 RUNX2 FBN1 TGFBR3 CTGF FBN2 TGFBR1 FBN3 LTBP2 SHC1 MAPK1 FLNA ENG MAPK3 POSTN MAPK14 TGFBR2 AGTR1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260211%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle MDH2 CS SDHC SDHD SDHB SDHA OGDH ACO2 IDH3B FH SUCLA2 DLD SUCLG2 SUCLG1 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260211%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN ACE2 VEGFA NRP1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260211%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways HSD11B1 HSD11B2 EBP SLC27A5 THEM5 DHCR7 ACOT8 ACOT7 ACOT11 ACOT12 BAAT ACOT13 ACOT9 AMACR ACOT6 SLC27A2 NPC1 ACOT4 DBP CYP7A1 EPHX2 CYP27A1 NPC2 AGE RAGE PATHWAY%WIKIPATHWAYS_20260211%WP2324%HOMO SAPIENS AGE RAGE pathway MMP9 EGFR SMAD2 RELA STAT1 INSR TIRAP INHBB FOXO1 SRC INS SHC1 IRS1 MAPK1 MAPK3 ATF2 HEL-S-44 MAP2K1 MAPK14 NFKBIA RAF1 ALPL NCF1 AGER PRKCB PRKCA HIF1A STAT5B EZR CYCS IRAK4 CASP9 PRKCZ MAPK9 MAPK8 MYD88 CASP3 CHUK STAT3 ROCK1 JUN NFKB1 SP1 CASP8 ARHA NOS2 CDC42 FOXO4 DDOST HEL70 MSR1 MMP7 IKBKB MMP2 RAC1 MMP14 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260211%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1i2 NR1H4 ABCC2 SLC51A SLC51B SULT2A1 ABCB1 BAAT ABCC3 SLCO1B1 ABCB11 CYP3A4 NR1I3 NR1i1 CYP7A1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260211%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 CDKN1A HIF1A ABCB1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2276%HOMO SAPIENS Glial cell differentiation HEL70 CNP MBP GAP43 FREP1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome NKX2-5 CDC45 CYP26A1 HIRA HIRIP3 PAX3 CYP26B1 GBX2 HEL25 SLC2A4 CYP26C1 FGFR2 SREBF2 TBX1 GSC2 HAND2 PAK4 CDH15 ACTA2 RORC CLDN3 PARK2 SLC25A1 HEL-S-80p DGCR8 DROSHA CRKL GP9 SNAP29 PLK1 SERPIND1 SEPT5 TXNRD2 TSKS ZDHHC8 RCC1 C22orf39 DRD2 THAP7 TSSK2 RTL10 HDAC3 NPRL2 TRMT2A ESS2 KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L GP1BA TNPO1 ASF1A SCARF2 EGFR DGCR2 GP1BB C16orf35 SLC7A4 GNB1L DEPDC5 FOXC2 CCDC188 FOXC1 ARVCF RANBP1 P2RX6 SHH ZNF74 PITX2 FGF10 CLDN1 NCOR1 BCL2 RAF1 FOXA2 RTN4 HES1 ALDH1A2 EMC10 POLR2A RELN RTN4R RBX1 MED15 FGF8 CLDN5 CDC42 UFD1L FGFR1 GLUD1 H4C9 CLTCL1 VWF RAN SHOC2 PRODH ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP138%HOMO SAPIENS Androgen receptor signaling EGFR CREBBP STUB1 SMAD4 EP300 RUNX2 RELA FHL2 FOXO1 EFCAB6 HEL32 SRC KAT7 KDM1A PIAS2 CTNNB1 ZNF318 FKBP4 RNF6 RNF4 TGFB1I1 BAG1 FLNA PATZ1 NCOR1 SMIM40 UBE2I SUMO1 SIRT1 HDAC1 TGIF1 RB1 PAK6 KAT2B CCND1 ZMIZ1 GSK3B RAD9A STAT3 TLE5 PIAS1 ROCK1 KAT5 ROCK2 UBE3A JUN HEL-S-99n PSMC3IP SP1 ARHA RLN1 PIK3R2 NCOR2 PIK3R1 CDC42 NR2C2 RHOB MDM2 CCNE1 HEL-S-67p NR0B2 PTEN BRCA1 CREB1 RAC1 RAN SIN3A CARM1 LIMK2 NCOA1 SMARCE1 ETV5 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260211%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome CFD HEL-S-62p ICMT LMNB2 RCE1 FNTA LMNA CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260211%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases ADHFE1 MDH2 ALDH7A1 HEL-S-5 GCDH L2HGDH D2HGDH APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260211%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3B BCL2L1 BCL2 BCL2L2 BAK1 ITGB4 BAX BOK PTHLH GSK3A MYC AKT3 BCL2A1 BCL2L10 ITGA6 BCL2L12 BCL2L14 MCL1 BCL2L13 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260211%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260211%WP550%HOMO SAPIENS Biogenic amine synthesis GAD2 PAH GAD1 ASMT TH TPH1 ChAT AANAT DDC ACHE MAOA HDC PNMT DBH LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260211%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 TRIM71 EGR1 SOX2 POU5F1 AXON GUIDANCE%WIKIPATHWAYS_20260211%WP5289%HOMO SAPIENS Axon guidance ITGB1 MYL12B DCC SLIT1 SHH SLIT3 TRPC1 SRC PDPK1 MAPK1 MET FYN RYK gdf7 SEMA5B RHOD ROBO3 DPYSL5 UNC5D HEL-S-28 SEMA7A EFNB1 RAF1 ABLIM3 ROBO2 LRIG2 CXCR4 SRGAP2 NTNG2 NGL1 SLIT2 EPHA2 PRKCA WNT4 NTN3 PARD3 CDK5 ARHGEF12 GSK3B RGMA HEL-S-15 PRKCZ EPHB1 GNAI1 CXCL12 ROCK1 NRP1 PARD6A RRAS PLXNA1 PTCH1 EFNA1 CDC42 SEMA3A BOC L1CAM FES FZD3 ROBO1 NCK1 BMPR2 RAC1 HRAS CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NCOA6 ABCC2 DNAJC7 SULT1A1 FOXO1 UGT1A4 CYP2C19 SP1 CYP3A4 RXRA NR1I3 UGT1A3 CYP2C9 CYP2A6 CYP2B6 SULT2A1 UGT1A1 EHHADH ABCB1 UGT1A9 ABCC3 SMC1A PTPA PPARGC1A CYP4A11 ALAS1 NCOA1 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260211%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis STAT2 OAS1 STAT1 IFI35 IRF9 IFIT3 IFNAR2 PIAS1 IFNGR1 IFNGR2 TYK2 IFIT1 IRF1 IFNAR1 IFITM1 PSMB8 SOCS1 IFNG JAK1 MX1 TAP1 HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260211%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 EGFR FST SMAD4 KRTAP8-1 BMP6 IGF1 MSX2 EGR2 BMP4 SFRP1 CD200 PERP GATA3 CTNNB1 CD34 CASP14 MSX1 SOX2 SOSTDC1 TP63 NOTCH2 ADAM17 NOTCH1 ZBTB16 WIF1 NR3C1 LEF1 HR Nbla10317 ATL1 HOXC12 KRTAP3-3 PHLDA1 IGFBP5 KRTAP15-1 SPINK6 SPINK5 TCF4 ADAMTS20 DSG1 TCF3 DSG4 IFNG GPR49 DLX3 KLK5 KLK4 GPRC5D LRIG1 KRTAP6-1 FOXE1 KRTAP2-4 GSDMA KLK13 KLK14 FOXN1 GTPBP4 KRT19 GJB6 KITLG GAS1 DKK3 FOXQ1 CTGF JUN NFATC1 NFKB1 DKK1 DKK4 RBPJ SMAD1 ELANE SOX9 DSC2 FZD1 BMPR1A FOS S100A4 RUNX3 KLK6 CD133 FOSB ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260211%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GUCY1A2 RELA CHUK GUCY1B1 IKBKG TMPRSS2 HMOX1 NFKB1 IL6 CXCL8 RXRA TNF CCL2 ACE2 GCLM NFKBIA GCLC NFE2L2 NQO1 SLC7A11 IL12A IKBKB IL1B MMP3 IRF3 KEAP1 GLUCURONIDATION%WIKIPATHWAYS_20260211%WP698%HOMO SAPIENS Glucuronidation UGDH UGT2B10 UGT2B4 PGM2 UGT1A8 PGM5 UGT2B7 UGT1A3 UGT1A10 UGT1A1 UGT2B28 UGT1A9 UGT1A5 UGT2B11 UGT1A4 UGT2B15 UGT2B17 UGT1A7 UGT2A2 PGM3 UGT2A1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260211%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport SLC19A1 SLC46A1 MTR FOLR1 MTHFD1 MTHFD2L SHMT1 HEL-S-51e TYMS MTHFD2 DHFR HEL-S-70p MTHFS FTCD IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260211%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF LYRM4 HSCB ABCB7 FDX1 NFU1 FDXR CIAO2B FXN ISCU NUBP1 NUBP2 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260211%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF EGFR RAF1 CASP3 HTT RPS6KA5 BDNF NTRK2 CREB1 MAPK1 MAPK3 HRAS MAP2K1 MAP2K2 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260211%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND2 PRL EPOR STAT1 STAT3 EPO CISH NRAS PRLR FOXM1 IFNGR1 SOCS2 CDK4 SOCS3 IL6 SOCS1 AKT3 KRAS RPTOR GHR MTOR MLST8 GH1 CCND3 IFNGR2 AKT1S1 IL6R IFNG STAT5B HRAS TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260211%WP5050%HOMO SAPIENS TCA cycle in senescence PDHA1 FH ME1 BRAF HEL-S-32 PDP2 ME2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2879%HOMO SAPIENS Farnesoid X receptor pathway NR1H4 UGT2B4 CYP8B1 SLC27A5 ABCB4 SULT2A1 NR0B2 SLCO2B1 BAAT ABCB11 FGF8A FKBP5 CYP3A4 RXRA PPARGC1A IP6K3 CYP7A1 NEUROINFLAMMATION%WIKIPATHWAYS_20260211%WP4919%HOMO SAPIENS Neuroinflammation TLR4 COX1 MAPK8 CHUK RELA JUN ASCC1 FOS NOS2 MAPK14 MTOR NFKBIA COX2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260211%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CREB1 MTR ADH5 CEBPB CBS CYP2E1 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260211%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ASL NAGS ASS1 ARG2 GLUD1 ARG1 ALDH18A1 SMS OTC HEL-S-29 HEL-S-5 SRM HEL-S-20 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260211%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NDUFB10 NDUFB11 CEBPA COX7A2 NDUFV3 NDUFV2 SOCS3 NDUFC2 NDUFC1 PRKAA2 NDUFS6 NDUFS5 NDUFS4 CCL2 NDUFS1 COX2 NDUFB9 BCL2L11 NDUFB8 PRKAG1 NDUFB7 PRKAG2 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 PRKAG3 NDUFB1 BBC3 NDUFA7 LEPR NDUFA6 PRKAB2 NDUFA5 ZNF183 NDUFA3 PRKAB1 NDUFA2 IL6R PIK3R3 ADIPOR1 NDUFAB1 ADIPOR2 VCAM1 MAPK9 MAPK8 TGFB1 BAX COX7B COX4I1 COXFA4L2 COX6A1 CXCL8 DDIT3 CASP8 COX8A PIK3R2 COX6B1 PIK3R1 COX7A1 SDHC XBP1 SDHD UQCRB SDHB COX3 CYP2E1 UQCR11 UQCR10 GSK3A CYB UQCRH UQCRQ UQCRC1 IKBKB UQCRFS1 CYC1 RAC1 UQCRC2 IL1A BAK1 INSR RELA INS FAS NR1C1 AKT3 IRS1 RXRA TNF MAP3K5 MAP3K11 ERN1 NR1H4 MLXIPL PRKAA1 TNFSF6 COX4I2 NR1H3 EIF2S1 CYCS ATF4 GSK3B LEP COX1 PIK3CD CASP3 TRAF2 SDHA JUN TNFRSF1A NDUFC2-KCTD14 PIK3CA COX6B2 NFKB1 COX7B2 MLX IL6 COX8C MLXIP UQCRHL NDUFA13 CDC42 PKLR COX7C NDUFS8 NDUFS3 COXFA4 COX5A NDUFA11 IL1B NDUFA9 NDUFA12 NDUFA10 COX6A2 ITCH COX7A2L SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260211%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SLCO1B1 HSD17B2 SLCO4C1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 NR3A2 SULT1E1 HSD17B1 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260211%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 B3GALT2 B3GALT1 FUT3 FUT1 FUT2 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260211%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin ANGPT2 ANGPT1 VEGFA GATA2 CX3CL1 CCL8 CCL5 MAP2K4 HLA-G CCL7 TNF MAPK3 CCL2 IL15RA CCL4 MAPK11 NR3A2 BCL2 PGR CXCR4 NR3C1 IFNG STAT5B JAK3 MCL1 VCAM1 IL2RB ITGA4 IL15 IL2RG CXCL12 IL10 IL4 IL6 CXCL8 GAB3 NCR2 MADCAM1 KIR2DL4 IL3 SELL CD69 PIBF1 JAK1 CXCR3 CXCL11 NCR1 NCR3 CCL3 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260211%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 CHDH SLC44A1 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260211%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ITGB1 CLDN4 ZEB2 TGFB1 ALPL SFRP1 TERT MYC ITGA6 TNF NRG3 ERBB4 CCND1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260211%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IRAK1 TLR4 IRAK4 IRF7 MYD88 CHUK TRAF3 TIRAP TRAF6 TBK1 IKBKG MAP3K7IP1 TRAM1 NFKB1 IL6 CXCL8 TNF INPP5D NFKBIA IRAK3 IKBKE RIPK1 MAP3K7 TICAM1 IFNB1 IKBKB IRF3 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260211%WP2006%HOMO SAPIENS miR targeted genes in squamous cell AP3D1 ARCN1 SPCS3 NEDD4 LAMTOR5 HEL-S-30 MET POGLUT3 AXL TPM3 TPM1 GYS1 RAB34 TMEM59 MAP3K8 NCL PTMAP7 RHEB LAMC1 SRSF9 RAI14 TMED10 CBFB ADIPOR2 SDCBP GAS2L1 TNFRSF10B VCAM1 HMGA1 SLC4A10 NF2 TBCA CHMP2A SRPRB DKFZp761E1322 PICALM THBS1 ADAR SYNE2 TUBA1A FBXW11 SMAD1 CTDSP1 SIGMAR1 SEC23A HSD17B12 UBE2J1 DNAJB1 POLR2C SPTLC1 POLD2 TGFBR2 SH3BP4 ATP6V1C1 ATP6V1F GFPT1 PDLIM7 SLC12A2 GALNT7 GALNT1 ATP6V0E1 FMNL2 CPNE8 VEZT CUL4B BET1 PWP1 PNP DHX57 CIAO2A GOLGA7 FNDC3B FNDC3A PISD RTN4 POM121 HES1 MRPL20 COMMD9 SLC38A1 PEDS1-UBE2V1 MOV10 RARS1 ANP32B RNP24 NRP1 HEL-S-26 ARF4 TRAM1 HMOX1 MAGT1 MRC2 TMEM43 HOXA7 SH3BGRL3 TMED7 ANXA2 E2F3 ATP2A2 ELOVL5 AP2A1 PRPF40A YWHAQ CSDE1 FGF2 P4HA2 PXDN MRPS33 AKAP8 PPP1R7 MPZL1 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260211%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway MCAT HSD17B12 ACACA MECR OXSM HTD2 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260211%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-117 ADH6 ALDH2 HEL-S-53e HEL-S-4 CYP2A6 CYP1A2 CYP1A1 CYP2E1 ADH1A ADH1C CYP3A4 CYP4A11 ADH7 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260211%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB NR1B3 RXRG RARA RXRA RARB DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260211%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GDF11 FST TGFB1 ANOS1 CELSR1 BMP4 SHH SPRY1 GRIP1 PAX2 SIX1 SMAD1 BMPER SMO GPC3 CRIM1 BMP7 BMP5 CTDNEP1 RARA HOXD11 FRAS1 HOXA11 FREM1 FREM2 GLI3 SALL1 ETV4 SIX2 BMPR1A BMPR2 NR1B3 EYA1 GDNF BMP2 CCND1 DCN RET ETV5 RARB HEME BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP561%HOMO SAPIENS Heme biosynthesis FECH UROD UROS HMBS CPOX ALAS1 ALAS2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260211%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex FLT3 GABPB1 BCL2L1 BCL2 SMARCA4 CREBBP ETV6 SMAD4 EP300 FOXO3A ZFX ATM GABPA PTEN TERF2 DNMT3B MCL1 PURINE METABOLISM%WIKIPATHWAYS_20260211%WP4792%HOMO SAPIENS Purine metabolism ADSL PNP HEL-S-70p XDH AMPD1 APRT IMPDH1 ADA ADSS DGUOK HPRT1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260211%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260211%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling ITGB1 MAP4K1 MAPK8 PAK1 PTGS2 STAT3 CRK JUN DOCK1 SRC PIK3CA RAP1A HGF MAPK1 CRKL MAPK3 MET PTPN11 MAP2K1 MAP2K2 RAPGEF1 RAF1 PXN FOS PTEN ITGA1 PTK2B HRAS GRB2 SOS1 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260211%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IRAK1 TLR4 IRAK4 IRF7 MAPK8 MYD88 RELA CHUK TRAF3 RELB TRAF6 IKBKG IL10 MAP3K7IP1 NFKB1 IL6 CXCL8 TNF CCL4 ELANE MAPK14 NFKBIA TLR7 MAP3K7 IRF1 NFKB2 IKBKB LCN2 REL TLR8 CCL3 VCAM1 IL1A AUTOPHAGY%WIKIPATHWAYS_20260211%WP4923%HOMO SAPIENS Autophagy DKFZp762B153 RB1CC1 WIPI2 ATG5 ATG14 AMBRA1 PRKAA2 RPTOR MTOR ULK1 PIK3R4 DEPTOR PRKAG1 MLST8 PRKAG2 ATG3 PRKAG3 PRKAA1 ATG9A ATG12 PRKAB2 ATG16L1 PRKAB1 AKT1S1 ATG101 UVRAG PURINERGIC SIGNALING%WIKIPATHWAYS_20260211%WP4900%HOMO SAPIENS Purinergic signaling P2RY11 ADORA2B GNAI1 P2RY6 P2RY4 P2RX6 GNAI3 P2RY2 P2RY1 PANX1 GNAS GNAO1 ADORA2A P2RY10 P2RY14 GNAZ P2RY8 GNAT2 GNAT3 GNAT1 LPAR4 P2RX7 P2RX5 GNA11 P2RX4 P2RX3 P2RX2 P2RX1 P2RY13 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260211%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions TLR4 NLRP3 MMP9 EGFR SMAD2 CNP EBI3 SIRPA FAM20C STAT1 PDGFA MBP CD47 IGF1 VEGFA TGFBR1 NKX2-2 IL10RA FOXO1 IGF1R MOG TYK2 PDGFRA OLIG1 CX3CR1 OLIG2 SOCS3 TNF CCL1 MAPK14 CTLA4 NKX6-1 CCL20 IL33 CSPG4 ITGB3 CD80 HEXB IL10RB IL12A CD68 NFKB2 IFNG STAT5B ITGA2 JAK3 OSM IL2RA IL2RB CD44 IL2RG MYD88 TGFB1 STAT3 CXCL12 TGFBR3 STAT4 IL12RB1 IL10 CCR8 FOXP3 NFKB1 HTR7 IL2 IL4 IL6 SPP1 NOS2 SOX9 PDCD1 CDC42 SSTR2 FOXO3A FOXO4 ROS1 ITGAV IKZF2 IL18 AIF1 CCN3 NKX6-2 TNFRSF1B IL1B KLRG1 RAC1 APOD MCAM JAK1 GSDMD TMEM119 TGFBR2 CXCL1 AREG CCR6 RETT SYNDROME%WIKIPATHWAYS_20260211%WP4312%HOMO SAPIENS Rett syndrome CDKL5 KCNJ10 XAB2 MEF2C TBL1XR1 IMPDH2 CHD4 HAP1 SCN8A HTT ACTL6B BRAF CRK SCN1A GABBR2 SCN2A HDAC5 HDAC8 SYNE2 GNAO1 NCOR1 STXBP1 NCOR2 SRRM3 SMARCA4 TAF1B FOXG1 HDAC1 SHANK3 SMARCA1 SMC1A TBL1X GRIN2B TCF4 SYNGAP1 EIF2B2 GABRA3 KDM5B TRRAP GPS2 RHOBTB2 CECR2 HIVEP2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260211%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MEF2C MIXL1 MESP1 THY1 NKX2-5 NCAM1 INHBA SIRPA IGF1 ZFP42 BMP4 POU5F1 ISL1 INS KDR PDGFRA PAX6 NRG1 GATA4 SOX1 SOX2 MAPK14 TBXT NOTCH1 BMP1 CXCR4 MESP2 FOXA2 IGF2 TBX20 IRX4 TBX5 KIT MYL2 WNT3A TNNI3 GSK3B SOX17 SCN5A TGFB1 LIN28A LIN28B ROR2 DKK1 NODAL FGF2 NOG MYH6 MYLK3 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260211%WP272%HOMO SAPIENS Blood clotting cascade SERPINB2 F13B PLAT KLKB1 PLG FGA VWF F2 HEL-S-78p KLNA1 F7 SERPINF2 F3 F5 F10 F8 F11 F9 WNT SIGNALING%WIKIPATHWAYS_20260211%WP428%HOMO SAPIENS Wnt signaling CAMK2A CCND2 DAAM2 PRICKLE2 GPC4 CAMK2G CTBP2 NFATC3 NFATC2 NFATC4 INVS WIF1 CCND3 MAP3K7 CCND1 MAPK9 MAPK8 FZD10 ROR2 FRAT1 FRAT2 CSNK2A1 CSNK2A3 NFATC1 CSNK2A2 CSNK1E DKK1 DKK2 DKK4 SFRP4 CSNK2B PPP3R1 PPP3R2 FOSL1 FZD1 WNT10B WNT10A FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 PPP3CA RAC1 PPP3CC PLCB4 PLCB1 PLCB2 DAAM1 CSNK1A1 WNT7B SFRP1 WNT7A CTNNB1 MYC CHD8 RYK ROR1 WNT5B SOST LEF1 NKD1 NKD2 PRKCB DVL1 PRKCA DVL2 TCF7L2 DVL3 TCF7L1 WNT1 WNT3 CTNNBIP1 WNT4 WNT3A VANGL1 KREMEN1 SENP2 SFRP5 CXXC4 PORCN GSK3B WNT2B NOTUM SOX17 CER1 AXIN1 ROCK2 JUN WNT16 NLK LRP5 LRP6 ARHA APC CTBP1 PLCB3 CAMK2D ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 PPAR SIGNALING%WIKIPATHWAYS_20260211%WP3942%HOMO SAPIENS PPAR signaling CPT2 ME1 RXRB CD36 RXRG FABP4 DBI PLIN1 NR1C1 PDPK1 ANGPTL4 UCP1 RXRA APOA5 OLR1 APOC3 FADS2 SCD CYP7A1 APOA2 CYP27A1 PCK1 HEL-S-28 CYP8B1 PLTP FABP1 PPARG SLC27A5 LPL SLC27A1 EHHADH CPT1C NR1C2 UBC NR1H3 SLC27A4 CYP4A11 PCK2 ACSL1 ACOX1 AQP7 ERBB SIGNALING%WIKIPATHWAYS_20260211%WP673%HOMO SAPIENS ErbB signaling CAMK2A EGFR PAK1 NRG4 NRAS BRAF CAMK2G FOXO1 SRC SHC1 PDPK1 MYC AKT3 NRG1 HBEGF ERBB2 MAP2K4 NRG2 EIF4EBP1 MAPK1 SOS2 ERBB4 KRAS MAPK3 SHC4 SHC2 MAP2K1 SHC3 MAP2K2 TGFA BCL2L11 ERBB3 EGF RAF1 RPS6KB2 CDKN1B RPS6KB1 PRKCB PRKCA PIK3R3 PAK6 PAK4 STAT5B CCND1 GSK3B PIK3CD MAPK10 MAPK9 MAPK8 ARAF PLCG2 CRK JUN PIK3CA NRG3 CRKL BAD MTOR PIK3R2 PIK3R1 MDM2 CBL EREG BTC NCK2 NCK1 CDKN1A ABL2 HRAS CAMK2D GRB2 AREG SOS1 STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260211%WP383%HOMO SAPIENS Striated muscle contraction pathway TNNT1 ACTA2 MYL3 TNNT3 MYH8 HEL113 MYL1 MYOM1 MYBPC3 TNNC1 TNNI1 ACTN2 DMD HEL-S-273 HEL-S-108 ACTN4 TTN ACTG1 tmp_locus_29 TPM3 TPM1 TMOD1 TCAP MYH6 ACTA1 MYL4 TNNI2 MYL2 TNNI3 TNNC2 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260211%WP4742%HOMO SAPIENS Ketogenesis and ketolysis CPT2 OXCT1 ACAT1 UCP2 BDH1 SLC25A20 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5393%HOMO SAPIENS Androgen biosynthesis HSD11B1 HSD11B2 SRD5A2 POR AKR1D1 AKR1C4 HSD3B1 SULT2A1 HSD17B3 CYP17A1 HSD17B2 AKR1C1 CYP3A7 AKR1C2 CYP3A4 HSD17B4 HSD17B1 HSD3B2 ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260211%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology HEL-S-15 ADCY3 ADCY1 SMAD2 ADCY8 SMAD4 ADCY6 WWTR1 TGFB1 LBR NRAS SYNE4 CTGF SYNE3 SUN1 YY1AP1 PLEC HEL-S-7a SYNE2 MAPK1 SYNE1 ARHA KRAS SOS2 MAPK3 TMEM43 HEL-S-61 MAP2K1 MAP2K2 BANF1 EMD ADCY9 LEMD3 HRAS GRB2 SOS1 PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260211%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m ERN1 ASNS NFE2L2 DNAJB11 BBC3 XBP1 SULT1E1 HEL-S-89n EIF2A EDEM1 HEL-S-99n DNAJC3 ERP27 TRIB3 DDIT3 DNAJB9 UBE2E1 PPP1R15A BCL2L11 NARS1 ATF3 ATF4 PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260211%WP5103%HOMO SAPIENS Progeria associated lipodystrophy RECQL SMAD2 PARP1 SMAD4 TGFB1 PPARG FBN1 ZMPSTE24 FNTA BANF1 LMNA INS KCNJ6 MUCL3 SPRTN ICMT LMNB2 WRN FFAR3 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260211%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection GUCY1A2 CAMK2A NPPB CASP9 PDE3A RELA PBR GUCY1B1 CAMK2G GRIN1 NFKB1 CNGB1 ACTN2 DLG4 CNGA3 CNGA4 AKAP9 TNF CNGB3 NEFL NOS2 PDE2A BAD NFKBIA CALM1 BCL2 NPPA GRIN2B IFNG CREB1 IL1B CNGA1 CAMK2D CYCS AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260211%WP5526%HOMO SAPIENS Age related macular degeneration PRKAG2 PRKAG3 PRKAA1 SIRT1 PRKAB2 RPS6KB1 PRKAB1 PRKAA2 PMAIP1 PPARGC1A MAPK3 RPTOR HEL-S-32 MTOR PARP2 PRKAG1 MLST8 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260211%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells CALCA ACTA2 SMAD2 CASP9 SMAD4 CASP3 BAK1 TGFB1 APAF1 TRPV5 BAX BRAF TGFBR1 PDE1B TNFRSF1A PIK3CA MAPK1 CASP8 SEC16B MAP3K5 HEL-S-41 MTOR FFAR3 PPP3R1 RAF1 TNFSF11 PTH MCU FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260211%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins CASP9 MAPK8 PAK1 CASP3 APAF1 CASP10 FAF1 MAP3K1 JUN DFFB MAPKAPK3 DFFA FAS ARHGDIB LMNB2 MAP2K4 TNF CASP8 RIPK2 NFX1 SMIM40 PRKDC BCL2 FADD PARP1 ACTG1 SPTAN1 TNFSF6 CASP6 PS1TP5BP1 LMNA MAP3K7 ACTA1 RB1 HEL-S-102 MAPKAPK2 CYCS IL1A P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260211%WP4963%HOMO SAPIENS p53 transcriptional gene network ADORA2B BTG2 AURKA PML ZMAT3 PERP LIF ISG15 FAS CX3CL1 TP53I3 CDK2 PRKAA2 TNF GPX1 CCL2 RPTOR SMR3B DEPTOR ACAD11 SERPINB5 PRKAG1 MLST8 SCO2 PRKAG2 ADGRB1 NOTCH1 DRAM1 RPRM SIVA1 MGMT ULBP2 PRKAG3 ULBP1 SESN2 PRKAA1 BBC3 TP53AIP1 IRF9 PIDD1 TNFSF6 DDIT4 SESN1 TIGAR FUCA1 PRKAB2 CPT1C PRKAB1 AKT1S1 SLC7A11 DDB2 RRM2B PMAIP1 TNFRSF10B TRAF4 CCNG1 POLK TSC2 XPC ERCC5 APAF1 BAX SFN MSH2 THBS1 FANCC ULK2 ULK1 MTOR GADD45A PCNA TNFRSF10D NCF2 CCNE1 E2F7 CDKN1A PTEN GLS2 TP53INP1 XRCC5 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260211%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders pcap MAT1A CDO1 ADK MTR CTH HEL-S-182mP HEL-S-61p CBS BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260211%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation SMAD9 SST FOXO1 SFRP1 DKFZp781O1323 CTNNB1 DKK1 WNT4 SMAD1 BMP2 DCN LEFTY2 BCL2L11 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260211%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3CA HLA-DRB1 PIK3CD PIK3R3 CD80 PPP2CA PTPN11 CTLA4 PTPN6 PIK3R2 PIK3R1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260211%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT1 HEL-S-277 PRMT7 NOS2 CARM1 PRMT3 PRMT2 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260211%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 HGS RAF1 ARAF PDCD6IP BRAF NRAS RAB5B RAB5C RRAS2 RRAS MAPK1 KRAS RAB27A MAPK3 HRAS RAB5A IL11 SIGNALING%WIKIPATHWAYS_20260211%WP2332%HOMO SAPIENS IL11 signaling BIRC5 TGFB1 RELA CHUK STAT1 STAT3 RUNX2 PIAS1 SRC TYK2 PDPK1 SOCS3 IL11 MAPK1 IL11RA BGLAP FYN MAPK3 ATF1 PTPN11 MAP2K1 MAP2K2 PIK3R2 IL6ST PIK3R1 BCL2 YES1 RAF1 FES RPS6 RPS6KA1 RPS6KB1 IBSP PTPA IKBKB CREB1 JAK1 HRAS ITGA2 GRB2 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260211%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COX11 ERBB2 MAPK1 ADRA2B ARHA MAPK3 CIAO2A ANKRD23 SNRNP200 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 DUSP2 CNNM4 FER1L5 STARD7 SEMA4C ARID5A COL2A1 ASTL NEURL3 ZP2 KANSL3 PLXNB2 MMS19 IL5 SIGNALING%WIKIPATHWAYS_20260211%WP127%HOMO SAPIENS IL5 signaling GSK3B SPRED1 STAT1 STAT3 JUN SHC1 IL2 IL5RA MAPK1 CSF2RB KRAS MAPK3 PTPN11 MAP2K1 LYN MAP2K2 PIK3R2 SYK PIK3R1 RAF1 RPS6KB2 FOXO3A RPS6 RPS6KA1 RPS6KB1 GSK3A JAK1 STAT5B BTK GRB2 SOS1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260211%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NLRP3 CARD9 CARD6 ACAP1 NLRP10 NOD2 CASP9 NLRP7 NLRP2 NLRP12 RELA CHUK IKBKG NLRP1 NAIP CASP8 DUOX2 CASP5 RIPK2 NFKBIA NDUFA13 PRDM1 AIM2 PYCARD COPS6 IL18 IKBKB IL1B RAC1 NOD1 NLRC4 MEFV AAMP CARD8 ERBIN LEPTIN SIGNALING%WIKIPATHWAYS_20260211%WP2034%HOMO SAPIENS Leptin signaling PDE3B RELA SH2B1 STAT1 CISH FOXO1 SRC SHC1 SOCS2 SOCS3 IRS1 ERBB2 PRKAA2 EIF4EBP1 MAPK1 FYN MAPK3 PTPN1 PTPN11 MAP2K1 MAPK14 MAP2K2 EIF4E SOCS7 ACACA RAF1 PRKAA1 RPS6 LEPR RPS6KB1 ACACB REL STAT5B CFL2 KHDRBS1 GSK3B LEP KPNA4 MAPK8 CHUK STAT3 PLCG2 IKBKG ROCK1 PLCG1 ROCK2 NFKB1 SP1 ARHA BAD MTOR PIK3R2 PIK3R1 CDC42 RPS6KA1 GSK3A PTEN IKBKB CREB1 RAC1 JAK1 HRAS GRB2 NCOA1 SOS1 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260211%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC1H1 DYNC2H1 DYNLRB2 IFT46 DYNLT1 IFT140 DYNC1LI2 IFT81 DNCL1 DYNLT3 IFT80 WDR35 IFT27 DYNLL2 IFT25 IFT43 DYNC1I1 DYNLT2B IFT22 DYNC1LI1 DYNC2I2 DYNC2LI1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260211%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine HEL-S-7a ADRB1 ADCY3 ADCY1 ADRB2 ADCY8 ADCY6 ADCY9 ADRA2C ADRA2B ADRA2A ADRA1D PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260211%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260211%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity ABCC2 CYP24A1 ABCD2 CYP26A1 NR1C1 CYP27B1 CYP3A4 NR1I3 NR1i1 ABCG5 CYP7A1 ABCD3 NR1i2 NR1H4 CYP8B1 RARA CYP2C9 PPARG ABCB4 CYP2B6 CYP1A2 ABCB1 ABCA1 CYP2E1 ABCC3 CYP4B1 NR1C2 ABCG1 ABCB11 NR1B3 NR1H3 CYP4A11 RARB HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260211%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA2 PDHA1 ACACA NFE2L2 PRKAA1 RPS6 VEGFA PRKAB1 ACACB EGLN1 HIF1A HEL-S-133P SLC11A2 PRKAG1 KEAP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP21A2 AKR1D1 AKR1C1 AKR1C4 AKR1C2 CYP3A4 CYP11B2 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260211%WP5171%HOMO SAPIENS Leukotriene metabolic pathway DPEP2 LTC4S DECR2 ALOX5 ABCC1 ALOX5AP PTGR1 DECR1 CYP4F3 PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260211%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX VLDLR NDEL1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260211%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP HIST1H2BE CDKN2A FZR1 RPS6KA2 RELA CEBPB UBE2D1 EHMT1 CDK4 RPS6KA3 CDK2 MAPK1 MAPK3 H2BC21 H2AX CDKN1B UBB ANAPC1 CCNA2 RPS27A CDKN2D CDKN2B CDKN2C H3C8 CDC26 STAT3 VENTX ANAPC15 C10orf104 UBE2S CDC27 JUN UBE2C MAPK7 NFKB1 H3C15 IL6 CXCL8 CDK6 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L HIST1H2AB H2BC9 H2AZ1 H2AZ2 RPS6KA1 H2BC8 CDC23 H4C9 H2AC6 HIST1H4L ANAPC7 FOS H2BC3 ANAPC5 UBC H2BC1 CDKN1A ANAPC2 H2BC17 H3F3B H2BC12 ANAPC11 H2BC13 H2AJ H2BC14 UBE2E1 H2BC15 IGFBP7 H2AC20 H2BC11 IL1A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260211%WP3645%HOMO SAPIENS NAD biosynthetic pathways NADSYN1 TDO2 NMNAT1 IDO1 PARP4 PARP1 NAPRT NAMPT BST1 SIRT1 SIRT3 TNKS2 SIRT6 SIRT4 HEL-S-90n SIRT5 SIRT7 TNKS PARP2 SIRT2 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260211%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HEXB HGSNAT HEXA HPSE2 IDUA GNS SGSH GALNS HYAL2 HYAL4 HPSE GUSB GLB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260211%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260211%WP129%HOMO SAPIENS Matrix metalloproteinases MMP16 MMP9 MMP15 MMP23B MMP17 MMP19 TCF20 MMP26 TNF TIMP4 TIMP3 MMP21 MMP20 MMP25 MMP24 MMP27 MMP28 hEMMPRIN MMP7 MMP2 MMP3 MMP10 MMP12 MMP11 TIMP1 MMP14 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260211%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 SMAD4 BMP6 RUNX2 IGF1 BMP4 DKFZp781O1323 BHLHE41 HMGB1 CSF1 PRKAA2 CTF1 LAMP2 NOTCH1 BCL2 CRY1 ATG3 BMP5 SP7 SOST ATG12 PTH TNFRSF11B CTSK ATG16L1 ATG101 PLEKHM1 CTHRC1 MAP1LC3A SQSTM1 ATG10 BMP2 PER1 CALCA LEP DKFZp762B153 RB1CC1 TGFB1 TRAF6 WNT16 VCP RORB NFATC1 BMP3 ATG5 DKK1 IL6 LRP5 AMBRA1 ARHGAP4 FYCO1 DRAM2 SMAD1 SEMA4D ULK1 MTOR IL3 SEMA3A SMAD9 TNFSF11 WNT10B EFNB2 BHLHB2 TNFRSF11A NPAS2 BMPR2 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260211%WP259%HOMO SAPIENS Nifedipine activity PCNA KDR BDKRB2 CYP3A4 MAPK1 PTK2B HEL-S-44 MAP2K1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260211%WP2876%HOMO SAPIENS Pregnane X receptor pathway NR1i2 ABCC2 CYP2C9 UGT1A3 CYP2A6 CYP2B6 SULT2A1 DNAJC7 UGT1A1 ABCB1 UGT1A9 FOXO1 ABCC3 SRC SLCO1B1 UGT1A4 CYP2C19 CYP3A7 CYP3A4 RXRA PPARGC1A SRPX2 CYP4F12 NCOA1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260211%WP35%HOMO SAPIENS G protein signaling PRKD3 ADCY3 ADCY1 PDE4A ADCY8 ADCY6 GNA14 GNG3 GNG5 GNG4 NRAS GNG7 GNG8 PDE1C AKAP5 PDE1B AKAP10 PDE1A PDE8A AKAP9 KRAS PDE7B PDE7A GNAZ PRKACG PRKCH PRKCB GNG10 GNA11 PRKCE GNGT2 PRKCA ADCY9 PRKAR1B GNAL PRKAR1A PRKCI PRKCQ PRKD1 PRKCZ GNAI1 GNAI3 GNG12 GNG11 GNG13 KCNJ3 GNA15 RRAS GNB2 ARHA GNB1 GNAS HEL159 GNB3 AKAP12 GNAO1 AKAP11 GNB5 AKAP7 AKAP6 CALM1 AKAP4 GNGT1 PDE4B PDE4D ARHGEF1 AKAP8 GNA13 PLCB3 PPP3CA PPP3CC HRAS ATM SIGNALING%WIKIPATHWAYS_20260211%WP2516%HOMO SAPIENS ATM signaling CHEK1 RAD9A MAPK9 TP73 MRE11A MDC1 IKBKG JUN CASP2 RAD50 TP53BP1 RAD51 CDK2 CRADD ATF2 GADD45A MDM4 H2AX PIDD1 MDM2 CCNE1 ATM TLK1 NBN RIPK1 SMC1A CDKN1A BRCA1 CCNB1 CREB1 CDC2 CHEK2 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260211%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 FADD CASP9 CASP3 APAF1 TNFSF6 CASP6 MAP3K1 TNFRSF1A CASP2 RIPK1 NFKB1 FAS CASP8 AIFM1 CYCS PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260211%WP4784%HOMO SAPIENS Proteoglycan biosynthesis EXT1 SLC35B2 CANT1 BPNT2 PAPSS2 CHST3 XYLT2 XYLT1 CHSY1 CSGALNACT1 B3GAT3 SLC26A2 B3GALT6 EXT2 CHST14 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260211%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260211%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP1 AXIN1 TNK2 TNK1 BTRC SKP1 DVL1 CTNNB1 DVL2 RBX1 DVL3 PARP10 APC PLK1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260211%WP2328%HOMO SAPIENS Allograft rejection HLA-DQA2 HLA-DQA1 HEL113 STAT1 VEGFA HLA-DRB1 FAS PDGFRA HLA-B HLA-F CCL19 HLA-G TNF HLA-DOA HLA-E HLA-DRA HLA-DOB CTLA4 AGTR1 HLA-DPA1 HLA-DQB1 CCL21 HLA-DMB C1QB HLA-DPB1 C1QA CD40 LRRK2 TNFSF6 CD80 C4B_2 C2 C4A C8A IL12B IL12A CXCR5 HEL-S-62p CD40LG IFNG GDNF HARS1 IL17A IL2RA C1QC IF2B1 HLA-DRB5 CASP9 PRKCZ IL-21 CASP3 TGFB1 HLA-DMA CXCL12 PRF1 IL10 IL13 CSNK2A2 FOXP3 HLA-A IL2 IL4 IL5 TUBA1B CXCL8 C6 C7 CASP8 HLA-C C9 CD55 GNLY BHMT2 PECR ABCB1 GABPA IL1B MICA CXCL9 CXCL13 CXCL11 IL1A PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260211%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome SNRPN NUP133 CDKN2A CCND2 PCM1 NUP98 RAE1 BDNF INS CDK4 DLX5 HEL-S-71 MSX1 HERC2 EIF4E TACR3 POM121 RNF8 PCSK1 RB1 CDKN2B CDKN2C CCND1 GHRH BBS4 GHRL PRKCZ AHCTF1 KISS1 UBE3A TUBGCP5 NIPA1 NDN TUBGCP6 TUBGCP4 NIPA2 FSHB GABRG2 SNURF ATP10A NUP85 TPR LHB CGA NUP107 CDK6 MDM4 POMC OXT NUP62 GNRH1 NUP188 NPAP1 NUP214 NDC1 MAGEL2 MDM2 GOLGA8S NUP88 GABRB3 NUP210 CYFIP1 GOLGA6L2 GABRR3 NUP93 FEZ1 FMR1 GABRR1 FEZ2 NUP54 NUP58 OCA2 NUP205 SLC45A2 GABRA5 NGF SEH1L AAAS GABRG3 NUP160 GABRG1 NHLH2 NUP42 RANBP2 NUP155 CDC6 NUP153 TYR NUP35 MKRN3 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260211%WP453%HOMO SAPIENS Inflammatory response pathway COL1A1 LAMA5 LAMB2 COL3A1 IL2RG ZAP70 TNFRSF1A THBS1 IL2 IL4 VTN IL5 IL5RA COL1A2 LAMB1 CD40 CD80 LAMC2 LAMC1 CD40LG IFNG TNFRSF1B LCK THBS3 IL2RA IL2RB GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260211%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG8 ALG9 ALG2 TUSC3 ALG14 ALG13 ALG3 B4GALT1 ALG12 ALG11 DPM3 DPM2 GCS1 DPM1 MAGT1 ALG1 ALG6 MGAT2 SRD5A3 DOLK DPAGT1 MPDU1 GMPPB CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260211%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CALM1 ATP2A1 HDAC2 CD8B1 MEF2D EP300 HDAC1 CD8A CABIN1 PLCG1 ZAP70 PPP3CA PPP3CC NFATC2 LCK ITPRIP RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260211%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway RS1 ANGPT4 BIRC5 ANGPT2 TNIP2 ITGB1 TNIP3 EGFR ANGPT1 PAK1 RELA NRAS GRB7 FOXO1 SRC RAD51 CTNNB1 MYC ERBB2 EIF4EBP1 MAPK1 MAPK12 KRAS MAPK3 MAPK13 PTPN11 MAPK11 MAPK14 NFKBIA GRB14 PXN STAT5B CASP9 MAPK9 MAPK8 CHUK STAT3 BAX YAP1 CRK IKBKG MSH2 PIK3CA NFKB1 NOS2 BAD PIK3R1 NCK1 IKBKB MMP2 RAC1 HRAS GRB2 SOS1 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260211%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia PIM1 PIM2 NOP2 CDKN1B FLT1 FOXO3A GAB2 ABCB1 LYL1 SKP2 PDGFRA CSF1R MYC ABCG2 KIT BCR GADD45A CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260211%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways EGFR CREBBP KDM5C EFCAB3 FLT1 PBRM1 EP300 SDSL PGBD5 LDHD VEGFA PSAT1 CAMK1 PSPH ENO1 KDR KSR1 HEL-S-68p SETD2 BHLHE41 PDGFRA HEL-S-30 SSPN RPTOR PHGDH DEPTOR MLST8 ACACA FASN HEL-S-51e GRB10 RHEB BAP1 AKT1S1 LDHB SQSTM1 ACACB HIF1A HEL-S-133P HK3 HEL-S-32 CEP290 KCNJ2 ME1 PGM2 MAP2K5 TSC2 TSC1 STAT3 HEL-S-162eP PFKL ACLY ENO2 PFKM ENO3 PLOD2 PFKP HEL-S-49 HEL-S-87p ENPP3 HK2 VHL MTOR RAPGEF5 PKLR ALDOB SHMT1 PTEN